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Search of human proteins with 7657575
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7657575 sirtuin 1 isoform a [Homo sapiens]
(747 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7657575 sirtuin 1 isoform a [Homo sapiens] 1518 0.0
gi|215982798 sirtuin 1 isoform b [Homo sapiens] 923 0.0
gi|13775600 sirtuin 2 isoform 1 [Homo sapiens] 207 3e-53
gi|13775602 sirtuin 2 isoform 2 [Homo sapiens] 207 4e-53
gi|6912660 sirtuin 3 isoform a [Homo sapiens] 194 2e-49
gi|63054862 sirtuin 3 isoform b [Homo sapiens] 184 3e-46
gi|6912664 sirtuin 5 isoform 1 [Homo sapiens] 94 6e-19
gi|13787215 sirtuin 5 isoform 2 [Homo sapiens] 91 3e-18
gi|6912662 sirtuin 4 [Homo sapiens] 80 5e-15
gi|7706710 sirtuin 6 [Homo sapiens] 70 7e-12
gi|21264339 SRY (sex determining region Y)-box 12 [Homo sapiens] 47 6e-05
gi|153070260 myristoylated alanine-rich protein kinase C substra... 45 2e-04
gi|21359951 RNA binding motif protein 42 [Homo sapiens] 45 2e-04
gi|110681712 hepatoma derived growth factor-like 1 [Homo sapiens] 45 2e-04
gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens] 44 4e-04
gi|27894378 chloride intracellular channel 6 [Homo sapiens] 42 0.002
gi|239754674 PREDICTED: hypothetical protein [Homo sapiens] 42 0.002
gi|21264565 AT rich interactive domain 1A isoform a [Homo sapiens] 42 0.002
gi|21264575 AT rich interactive domain 1A isoform b [Homo sapiens] 42 0.002
gi|122937267 lemur tyrosine kinase 3 [Homo sapiens] 42 0.002
gi|154759255 collagen, type XXVIII precursor [Homo sapiens] 42 0.002
gi|98985810 alpha 1 type XI collagen isoform B preproprotein [Ho... 41 0.005
gi|98985808 alpha 1 type XI collagen isoform C preproprotein [Ho... 41 0.005
gi|98985806 alpha 1 type XI collagen isoform A preproprotein [Ho... 41 0.005
gi|4503257 death-domain associated protein isoform a [Homo sapiens] 41 0.005
gi|215422388 death-domain associated protein isoform a [Homo sap... 41 0.005
gi|215422366 death-domain associated protein isoform b [Homo sap... 41 0.005
gi|30795231 brain abundant, membrane attached signal protein 1 [... 41 0.005
gi|165905613 ring finger and KH domain containing 1 [Homo sapiens] 41 0.005
gi|30061556 SRY (sex determining region Y)-box 3 [Homo sapiens] 40 0.008
>gi|7657575 sirtuin 1 isoform a [Homo sapiens]
Length = 747
Score = 1518 bits (3929), Expect = 0.0
Identities = 747/747 (100%), Positives = 747/747 (100%)
Query: 1 MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREV 60
MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREV
Sbjct: 1 MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREV 60
Query: 61 PAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNL 120
PAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNL
Sbjct: 61 PAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNL 120
Query: 121 YDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRP 180
YDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRP
Sbjct: 121 YDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRP 180
Query: 181 RIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDI 240
RIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDI
Sbjct: 181 RIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDI 240
Query: 241 NTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIE 300
NTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIE
Sbjct: 241 NTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIE 300
Query: 301 YFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRII 360
YFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRII
Sbjct: 301 YFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRII 360
Query: 361 QCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPE 420
QCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPE
Sbjct: 361 QCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPE 420
Query: 421 QFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLG 480
QFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLG
Sbjct: 421 QFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLG 480
Query: 481 DCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSS 540
DCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSS
Sbjct: 481 DCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSS 540
Query: 541 PERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDL 600
PERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDL
Sbjct: 541 PERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDL 600
Query: 601 KNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSD 660
KNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSD
Sbjct: 601 KNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSD 660
Query: 661 SEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTD 720
SEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTD
Sbjct: 661 SEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTD 720
Query: 721 GDDQEAINEAISVKQEVTDMNYPSNKS 747
GDDQEAINEAISVKQEVTDMNYPSNKS
Sbjct: 721 GDDQEAINEAISVKQEVTDMNYPSNKS 747
>gi|215982798 sirtuin 1 isoform b [Homo sapiens]
Length = 452
Score = 923 bits (2386), Expect = 0.0
Identities = 452/452 (100%), Positives = 452/452 (100%)
Query: 296 MFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAG 355
MFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAG
Sbjct: 1 MFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAG 60
Query: 356 IQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFG 415
IQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFG
Sbjct: 61 IQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFG 120
Query: 416 ENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFD 475
ENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFD
Sbjct: 121 ENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFD 180
Query: 476 VELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVS 535
VELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVS
Sbjct: 181 VELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVS 240
Query: 536 EDSSSPERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQM 595
EDSSSPERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQM
Sbjct: 241 EDSSSPERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQM 300
Query: 596 ENPDLKNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGA 655
ENPDLKNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGA
Sbjct: 301 ENPDLKNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGA 360
Query: 656 EVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGA 715
EVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGA
Sbjct: 361 EVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGA 420
Query: 716 GFGTDGDDQEAINEAISVKQEVTDMNYPSNKS 747
GFGTDGDDQEAINEAISVKQEVTDMNYPSNKS
Sbjct: 421 GFGTDGDDQEAINEAISVKQEVTDMNYPSNKS 452
>gi|13775600 sirtuin 2 isoform 1 [Homo sapiens]
Length = 389
Score = 207 bits (527), Expect = 3e-53
Identities = 111/261 (42%), Positives = 171/261 (65%), Gaps = 14/261 (5%)
Query: 214 ELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQE--CKKIIVLTGAGVSVSCGIP 271
E D L + LS ++++ D T+E + +Q C+++I L GAG+S S GIP
Sbjct: 35 EADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIP 94
Query: 272 DFRSRD-GIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFI 330
DFRS G+Y L + LP P+A+F+I YF+K P PFF AKE+YPGQF+P++CH F+
Sbjct: 95 DFRSPSTGLYDNL--EKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFM 152
Query: 331 ALSDKEGKLLRNYTQNIDTLEQVAGIQR--IIQCHGSFATASCL--ICKYKVDCEAVRGD 386
L +G LLR YTQNIDTLE++AG+++ +++ HG+F T+ C+ C+++ ++
Sbjct: 153 RLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEK 212
Query: 387 IFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVR 446
IF++V P+C C +++KP+IVFFGE+LP +F M+ D +VDLL+V+G+SL+V+
Sbjct: 213 IFSEVTPKCEDCQ-----SLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQ 267
Query: 447 PVALIPSSIPHEVPQILINRE 467
P A + S P P++LIN+E
Sbjct: 268 PFASLISKAPLSTPRLLINKE 288
>gi|13775602 sirtuin 2 isoform 2 [Homo sapiens]
Length = 352
Score = 207 bits (526), Expect = 4e-53
Identities = 108/247 (43%), Positives = 167/247 (67%), Gaps = 14/247 (5%)
Query: 228 LSEPPKRKKRKDINTIEDAVKLLQE--CKKIIVLTGAGVSVSCGIPDFRSRD-GIYARLA 284
LS ++++ D T+E + +Q C+++I L GAG+S S GIPDFRS G+Y L
Sbjct: 12 LSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNL- 70
Query: 285 VDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYT 344
+ LP P+A+F+I YF+K P PFF AKE+YPGQF+P++CH F+ L +G LLR YT
Sbjct: 71 -EKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYT 129
Query: 345 QNIDTLEQVAGIQR--IIQCHGSFATASCL--ICKYKVDCEAVRGDIFNQVVPRCPRCPA 400
QNIDTLE++AG+++ +++ HG+F T+ C+ C+++ ++ IF++V P+C C
Sbjct: 130 QNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQ- 188
Query: 401 DEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVP 460
+++KP+IVFFGE+LP +F M+ D +VDLL+V+G+SL+V+P A + S P P
Sbjct: 189 ----SLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTP 244
Query: 461 QILINRE 467
++LIN+E
Sbjct: 245 RLLINKE 251
>gi|6912660 sirtuin 3 isoform a [Homo sapiens]
Length = 399
Score = 194 bits (494), Expect = 2e-49
Identities = 106/263 (40%), Positives = 167/263 (63%), Gaps = 18/263 (6%)
Query: 242 TIEDAVKLLQE--CKKIIVLTGAGVSVSCGIPDFRSR-DGIYARLAVDFPDLPDPQAMFD 298
+++D +L++ C++++V+ GAG+S GIPDFRS G+Y+ L DLP P+A+F+
Sbjct: 124 SLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQY--DLPYPEAIFE 181
Query: 299 IEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGI-- 356
+ +F +P+PFF AKE+YPG ++P++ H F+ L +G LLR YTQNID LE+V+GI
Sbjct: 182 LPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPA 241
Query: 357 QRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGE 416
++++ HG+FA+A+C +C+ E +R D+ VPRCP C ++KP+IVFFGE
Sbjct: 242 SKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVC-----TGVVKPDIVFFGE 296
Query: 417 NLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHF-- 474
LP++F + D DLL+++G+SL+V P A + ++ VP++LINR+ + L +
Sbjct: 297 PLPQRFLLHV-VDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHP 355
Query: 475 ---DVELLGDCDVIINELCHRLG 494
DV LGD + L LG
Sbjct: 356 RSRDVAQLGDVVHGVESLVELLG 378
>gi|63054862 sirtuin 3 isoform b [Homo sapiens]
Length = 257
Score = 184 bits (467), Expect = 3e-46
Identities = 102/244 (41%), Positives = 153/244 (62%), Gaps = 16/244 (6%)
Query: 259 LTGAGVSVSCGIPDFRSR-DGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIY 317
+ GAG+S GIPDFRS G+Y+ L DLP P+A+F++ +F +P+PFF AKE+Y
Sbjct: 1 MVGAGISTPSGIPDFRSPGSGLYSNLQQY--DLPYPEAIFELPFFFHNPKPFFTLAKELY 58
Query: 318 PGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGI--QRIIQCHGSFATASCLICK 375
PG ++P++ H F+ L +G LLR YTQNID LE+V+GI ++++ HG+FA+A+C +C+
Sbjct: 59 PGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQ 118
Query: 376 YKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDL 435
E +R D+ VPRCP C ++KP+IVFFGE LP++F + D DL
Sbjct: 119 RPFPGEDIRADVMADRVPRCPVC-----TGVVKPDIVFFGEPLPQRFLLHV-VDFPMADL 172
Query: 436 LIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHF-----DVELLGDCDVIINELC 490
L+++G+SL+V P A + ++ VP++LINR+ + L + DV LGD + L
Sbjct: 173 LLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLV 232
Query: 491 HRLG 494
LG
Sbjct: 233 ELLG 236
>gi|6912664 sirtuin 5 isoform 1 [Homo sapiens]
Length = 310
Score = 93.6 bits (231), Expect = 6e-19
Identities = 79/282 (28%), Positives = 124/282 (43%), Gaps = 34/282 (12%)
Query: 235 KKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQ 294
K + +++ D K + K I++++GAGVS G+P FR G + + DL P
Sbjct: 32 KMARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQ--DLATPL 89
Query: 295 AMFDIEYFRKDPR---PFFKFAKEIYPGQFQPSLCHKFIALSD----KEGKLLRNYTQNI 347
A F +P F+ + +E+ G +P+ H+ IA + K+G+ + TQNI
Sbjct: 90 A------FAHNPSRVWEFYHYRREVM-GSKEPNAGHRAIAECETRLGKQGRRVVVITQNI 142
Query: 348 DTLEQVAGIQRIIQCHGSFATASCLIC-----KYKVD-CEAVRGDIFNQV--------VP 393
D L + AG + +++ HGS C C YK C A+ G + V
Sbjct: 143 DELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVE 202
Query: 394 RCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALI-P 452
+ PRC +++P +V+FGENL + + DL +V+G+S V P A+ P
Sbjct: 203 KLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAP 262
Query: 453 SSIPHEVPQILINREPLPHLH-FDVELLGDCDVIINE--LCH 491
VP N E P + F G C + E CH
Sbjct: 263 QVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEALACH 304
>gi|13787215 sirtuin 5 isoform 2 [Homo sapiens]
Length = 299
Score = 91.3 bits (225), Expect = 3e-18
Identities = 76/274 (27%), Positives = 122/274 (44%), Gaps = 31/274 (11%)
Query: 235 KKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQ 294
K + +++ D K + K I++++GAGVS G+P FR G + + DL P
Sbjct: 32 KMARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQ--DLATPL 89
Query: 295 AMFDIEYFRKDPR---PFFKFAKEIYPGQFQPSLCHKFIALSD----KEGKLLRNYTQNI 347
A F +P F+ + +E+ G +P+ H+ IA + K+G+ + TQNI
Sbjct: 90 A------FAHNPSRVWEFYHYRREVM-GSKEPNAGHRAIAECETRLGKQGRRVVVITQNI 142
Query: 348 DTLEQVAGIQRIIQCHGSFATASCLIC-----KYKVD-CEAVRGDIFNQV--------VP 393
D L + AG + +++ HGS C C YK C A+ G + V
Sbjct: 143 DELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVE 202
Query: 394 RCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALI-P 452
+ PRC +++P +V+FGENL + + DL +V+G+S V P A+ P
Sbjct: 203 KLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAP 262
Query: 453 SSIPHEVPQILINREPLPHLHFDVELLGDCDVII 486
VP N E P + L+ +II
Sbjct: 263 QVAARGVPVAEFNTETTPATNRFSHLISISSLII 296
>gi|6912662 sirtuin 4 [Homo sapiens]
Length = 314
Score = 80.5 bits (197), Expect = 5e-15
Identities = 73/240 (30%), Positives = 115/240 (47%), Gaps = 47/240 (19%)
Query: 239 DINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRD-GIYARLAVDFPDLPDPQAMF 297
D +++ + + K+++V+TGAG+S GIPD+RS G+YAR D + +
Sbjct: 40 DPEKVKELQRFITLSKRLLVMTGAGISTESGIPDYRSEKVGLYART--------DRRPIQ 91
Query: 298 DIEYFRKDPRPFFKFAKEI--YP--GQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQV 353
++ R P +A+ +P QP+ H ++ +K GKL TQN+D L
Sbjct: 92 HGDFVRSAPIRQRYWARNFVGWPQFSSHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTK 151
Query: 354 AGIQRIIQCHGSFATASCLIC-----------KYKV-----DCE----AVRGDIF---NQ 390
AG +R+ + HG CL C +++V E A GD+F Q
Sbjct: 152 AGSRRLTELHGCMDRVLCLDCGEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLSEEQ 211
Query: 391 V----VPRCPRCPADEPLAIMKPEIVFFGENL-PEQFHRAMKYDKDEVDLLIVIGSSLKV 445
V VP C +C +KP++VFFG+ + P++ K K E D L+V+GSSL+V
Sbjct: 212 VRSFQVPTCVQCGGH-----LKPDVVFFGDTVNPDKVDFVHKRVK-EADSLLVVGSSLQV 265
>gi|7706710 sirtuin 6 [Homo sapiens]
Length = 355
Score = 70.1 bits (170), Expect = 7e-12
Identities = 75/339 (22%), Positives = 134/339 (39%), Gaps = 49/339 (14%)
Query: 230 EPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPD 289
+PP+ +RK + + +L+ + ++ TGAG+S + GIPDFR G++
Sbjct: 25 DPPEELERK----VWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTME------ 74
Query: 290 LPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDT 349
+ P F E +P+ H + ++ G L +QN+D
Sbjct: 75 -------------ERGLAPKFDTTFE----SARPTQTHMALVQLERVGLLRFLVSQNVDG 117
Query: 350 LEQVAGIQR--IIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIM 407
L +G R + + HG+ C CK + + V G + + R L
Sbjct: 118 LHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRAC 177
Query: 408 KPE----IVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQ-I 462
+ E I+ + ++LP++ DL I +G+SL++RP +P + + +
Sbjct: 178 RGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLV 237
Query: 463 LINREPLPH-LHFDVELLGDCDVIINELCHRLGGE--------YAKLCCNPV------KL 507
++N +P H H D+ + G D ++ L LG E + P+ KL
Sbjct: 238 IVNLQPTKHDRHADLRIHGYVDEVMTRLMEHLGLEIPAWDGPRVLERALPPLPRPPTPKL 297
Query: 508 SEITEKPPRTQKELAYLSELPPTPLHVSEDSSSPERTSP 546
E P R + + P H + +SP+R P
Sbjct: 298 EPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERP 336
>gi|21264339 SRY (sex determining region Y)-box 12 [Homo sapiens]
Length = 315
Score = 47.0 bits (110), Expect = 6e-05
Identities = 46/150 (30%), Positives = 62/150 (41%), Gaps = 27/150 (18%)
Query: 13 GSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEP---GGAAPERE--------VP 61
G+P+ A R S G L+ P+ G G R+ G P G AAPE + +
Sbjct: 117 GAPAKA-RPRPPGGSGGGSRLKPGPQLPGRGGRRAAGGPLGGGAAAPEDDDEDDDEELLE 175
Query: 62 AAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNLY 121
PG LWR A AA G + AQ + GEG P+
Sbjct: 176 VRLVETPGRE---LWRMVPAGRAARGQAERAQGPS--GEGAAAAAAASPT---------- 220
Query: 122 DEDDDDEGEEEEEAAAAAIGYRDNLLFGDE 151
+D++ EEEEEAAAA G + + G+E
Sbjct: 221 PSEDEEPEEEEEEAAAAEEGEEETVASGEE 250
>gi|153070260 myristoylated alanine-rich protein kinase C substrate
[Homo sapiens]
Length = 332
Score = 45.4 bits (106), Expect = 2e-04
Identities = 49/158 (31%), Positives = 64/158 (40%), Gaps = 28/158 (17%)
Query: 4 EAALALQPGGSPSAAGADREAASSPAGEPLRKRPRR---------DGPGLERSPGEPGGA 54
EAA A SP A A SP+ E +K+ +R G +++ E G
Sbjct: 125 EAASAASSTSSPKAEDG---ATPSPSNETPKKKKKRFSFKKSFKLSGFSFKKNKKEAGEG 181
Query: 55 APEREVPAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPS--- 111
E E PAA G AA A A AEA AA GEQ A A G+ G P
Sbjct: 182 G-EAEAPAAEGGKDEAAGGA--AAAAAEAGAASGEQAAAPGEEAAAGEEGAAGGDPQEAK 238
Query: 112 --------REPPLADNLYDEDDDDEGEEE--EEAAAAA 139
+PP +D ++ + EE+ EEA A+A
Sbjct: 239 PQEAAVAPEKPPASDETKAAEEPSKVEEKKAEEAGASA 276
Score = 33.5 bits (75), Expect = 0.74
Identities = 50/163 (30%), Positives = 69/163 (42%), Gaps = 36/163 (22%)
Query: 14 SPSAA--GADREA---ASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAARGCP 68
SP+AA GA E S+PA + ++ P G G SP +A E+ PAAA P
Sbjct: 46 SPAAAESGAKEELQANGSAPAAD--KEEPAAAGSGAA-SP-----SAAEKGEPAAA-AAP 96
Query: 69 GAAAAALWREA--EAEAAAAGGEQEAQATAA-AGEGDNGPGLQ-----GPSREPP----- 115
A A+ + +EA E EAA G A+ AA A + P + PS E P
Sbjct: 97 EAGASPVEKEAPAEGEAAEPGSPTAAEGEAASAASSTSSPKAEDGATPSPSNETPKKKKK 156
Query: 116 ---------LADNLYDEDDDDEGEEEEEAAAAAIGYRDNLLFG 149
L+ + ++ + GE E A AA G +D G
Sbjct: 157 RFSFKKSFKLSGFSFKKNKKEAGEGGEAEAPAAEGGKDEAAGG 199
Score = 30.0 bits (66), Expect = 8.2
Identities = 35/129 (27%), Positives = 45/129 (34%), Gaps = 17/129 (13%)
Query: 2 ADEAALALQPGGSPSAAGADREAAS---SPAGEPLRKRPRRDGPGLERSPGEPGGAAPER 58
A AA A G +AA + AA + G+P +P+ E+ P A E
Sbjct: 201 AAAAAEAGAASGEQAAAPGEEAAAGEEGAAGGDPQEAKPQEAAVAPEKPPASDETKAAEE 260
Query: 59 ----------EVPAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQ 108
E A+A C +AA E EAA A E A AAA P +
Sbjct: 261 PSKVEEKKAEEAGASAAACEAPSAAGPGAPPEQEAAPA----EEPAAAAASSACAAPSQE 316
Query: 109 GPSREPPLA 117
P A
Sbjct: 317 AQPECSPEA 325
>gi|21359951 RNA binding motif protein 42 [Homo sapiens]
Length = 480
Score = 45.4 bits (106), Expect = 2e-04
Identities = 41/115 (35%), Positives = 48/115 (41%), Gaps = 13/115 (11%)
Query: 16 SAAGADREAASSPAGEPLRKRPRRDGPG-------LERSPGEPGGAA----PEREVPAAA 64
SAA R A P + L P PG + R+PG P G+ P E PAA
Sbjct: 175 SAAAGPRPMALRPPHQALVGPPLPGPPGPPMMLPPMARAPGPPLGSMAALRPPLEEPAAP 234
Query: 65 RGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEG--DNGPGLQGPSREPPLA 117
R L + EA AAA G +EA A A G G GP + GPS LA
Sbjct: 235 RELGLGLGLGLKEKEEAVVAAAAGLEEASAAVAVGAGGAPAGPAVIGPSLPLALA 289
>gi|110681712 hepatoma derived growth factor-like 1 [Homo sapiens]
Length = 251
Score = 45.1 bits (105), Expect = 2e-04
Identities = 47/157 (29%), Positives = 65/157 (41%), Gaps = 11/157 (7%)
Query: 1 MADEAALALQPGGSPSAAGADRE------AASSPAGEPLRKRPRRDGPG-LERSPGEPGG 53
+A E P P AA D + G+P +P + G L+RS G+P
Sbjct: 95 LASEKGSGDGPWPEPEAAEGDEDKPTHAGGGGDELGKPDDDKPTEEEKGPLKRSAGDPPE 154
Query: 54 AAPEREVPAAARGCPGAAA--AALWREAEAEAAAAGGEQEAQATAAA--GEGDNGPGLQG 109
AP+R AA A A AA A A AAA ++E+ A G + PGL
Sbjct: 155 DAPKRPKEAAPDQEEEAEAERAAEAERAAAAAAATAVDEESPFLVAVENGSAPSEPGLVC 214
Query: 110 PSREPPLADNLYDEDDDDEGEEEEEAAAAAIGYRDNL 146
+P + +E D+E +E A A G RD+L
Sbjct: 215 EPPQPEEEELREEEVADEEASQEWHAEAPGGGDRDSL 251
>gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]
Length = 2944
Score = 44.3 bits (103), Expect = 4e-04
Identities = 41/132 (31%), Positives = 54/132 (40%), Gaps = 18/132 (13%)
Query: 13 GSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAARGCPGAAA 72
G P A G R+ AS G+ R PG+ SPG PG P+ E G PG A
Sbjct: 2254 GKPGAPG--RDGASGKDGD-------RGSPGVPGSPGLPGPVGPKGE--PGPTGAPGQAV 2302
Query: 73 AALWREAEAEAAAAGGEQEAQATAAAGEGDNG-PGLQGPSREPPLADNLYDEDDDDEGEE 131
L A+ E A GG +GD G PG +G E A + D GE+
Sbjct: 2303 VGL-PGAKGEKGAPGGLAGDLVGEPGAKGDRGLPGPRGEKGEAGRAG-----EPGDPGED 2356
Query: 132 EEEAAAAAIGYR 143
++ A G++
Sbjct: 2357 GQKGAPGPKGFK 2368
Score = 38.1 bits (87), Expect = 0.030
Identities = 39/122 (31%), Positives = 50/122 (40%), Gaps = 20/122 (16%)
Query: 5 AALALQPG-----GSPSAAGADREAAS-SPAGEPLRKRPR----RDGP-GLERSPGEPGG 53
+ LA +PG G P AG EA GE K R RDGP GL +PG PG
Sbjct: 2030 SGLAGEPGKPGIPGLPGRAGGVGEAGRPGERGERGEKGERGEQGRDGPPGLPGTPGPPGP 2089
Query: 54 AAPEREVPAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNG-PGLQGPSR 112
P+ V G G + A+ E + G + +GD G PG++G
Sbjct: 2090 PGPKVSVDEPGPGLSGEQGPPGLKGAKGEPGSNGDQ--------GPKGDRGVPGIKGDRG 2141
Query: 113 EP 114
EP
Sbjct: 2142 EP 2143
Score = 34.7 bits (78), Expect = 0.33
Identities = 36/124 (29%), Positives = 42/124 (33%), Gaps = 15/124 (12%)
Query: 4 EAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDG----PGLERSPGEPGGAAPERE 59
E +A G P G+ P G P +K + D PGL PG PG P
Sbjct: 1415 EGGIAPGEPGLPGLPGSP--GPQGPVGPPGKKGEKGDSEDGAPGLPGQPGSPGEQGPRGP 1472
Query: 60 V----PAAARGCPGAAAAALWREAEAEAAAAGGE----QEAQATAAAGEGDNGP-GLQGP 110
P RG PG A + AG + A EG GP G QG
Sbjct: 1473 PGAIGPKGDRGFPGPLGEAGEKGERGPPGPAGSRGLPGVAGRPGAKGPEGPPGPTGRQGE 1532
Query: 111 SREP 114
EP
Sbjct: 1533 KGEP 1536
Score = 31.2 bits (69), Expect = 3.7
Identities = 35/141 (24%), Positives = 47/141 (33%), Gaps = 25/141 (17%)
Query: 13 GSPSAAGADREAA-SSPAGEPLRKRPRR--------------DGPGLERSPGEPGGAAPE 57
G+P A G P G+P + PR +GPGL G+PG + P
Sbjct: 1317 GTPGAPGLKGSPGLPGPRGDPGERGPRGPKGEPGAPGQVIGGEGPGLPGRKGDPGPSGPP 1376
Query: 58 RE----VPAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEG-----DNGPGLQ 108
RG PG A+ + + + G + A GE PG Q
Sbjct: 1377 GPRGPLGDPGPRGPPGLPGTAM-KGDKGDRGERGPPGPGEGGIAPGEPGLPGLPGSPGPQ 1435
Query: 109 GPSREPPLADNLYDEDDDDEG 129
GP P D +D G
Sbjct: 1436 GPVGPPGKKGEKGDSEDGAPG 1456
Score = 30.4 bits (67), Expect = 6.3
Identities = 30/106 (28%), Positives = 35/106 (33%), Gaps = 3/106 (2%)
Query: 11 PGGSPSAAG-ADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAARGCPG 69
P GS G A R A P G P R+ G PG+P P P +G G
Sbjct: 1502 PAGSRGLPGVAGRPGAKGPEGPP-GPTGRQGEKGEPGRPGDPAVVGPAVAGPKGEKGDVG 1560
Query: 70 AAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGP-GLQGPSREP 114
A + E G GD GP GL G + P
Sbjct: 1561 PAGPRGATGVQGERGPPGLVLPGDPGPKGDPGDRGPIGLTGRAGPP 1606
>gi|27894378 chloride intracellular channel 6 [Homo sapiens]
Length = 686
Score = 42.4 bits (98), Expect = 0.002
Identities = 41/133 (30%), Positives = 52/133 (39%), Gaps = 15/133 (11%)
Query: 5 AALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAA 64
A LA +PG P AAG + E G + P + E GG P+R A A
Sbjct: 22 APLAERPG-EPGAAGGEAEGPEGSEGA-------EEAPRGAAAVKEAGGGGPDRGPEAEA 73
Query: 65 RGCPGAAAAALWREAEAEAAAA--GGEQEAQATAAAGEGDNGPGLQGPSREPPLADNLYD 122
RG GA E E A GGE+ + A G G G QG P + +
Sbjct: 74 RGTRGAHGETEAEEGAPEGAEVPQGGEETSGAQQVEG-ASPGRGAQG----EPRGEAQRE 128
Query: 123 EDDDDEGEEEEEA 135
+D E +EEA
Sbjct: 129 PEDSAAPERQEEA 141
Score = 38.9 bits (89), Expect = 0.018
Identities = 44/141 (31%), Positives = 56/141 (39%), Gaps = 23/141 (16%)
Query: 11 PGGSPSAAGA---DREAASSPAGEPLRKRPRRDGPG--LERSPGEP-----GGAAPEREV 60
P G AG D A PAG+ + +GP R GEP G +P+ E
Sbjct: 255 PAGDGVEAGVPAGDSVEAEGPAGDSMDA----EGPAGRARRVSGEPQQSGDGSLSPQAEA 310
Query: 61 PAAARG-----CPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPP 115
A G PG A EAE G E+ A A A G++ G GP +EP
Sbjct: 311 IEVAAGESAGRSPGELAWDAAEEAEVPGVK-GSEEAAPGDARADAGEDRVG-DGPQQEP- 367
Query: 116 LADNLYDEDDDDEGEEEEEAA 136
++ + EG EEEAA
Sbjct: 368 -GEDEERRERSPEGPREEEAA 387
Score = 36.2 bits (82), Expect = 0.11
Identities = 36/120 (30%), Positives = 46/120 (38%), Gaps = 14/120 (11%)
Query: 29 AGEPLRKRPRRDGPG-----LERSPGEPGGAAPEREVPAAARGCPGA-AAAALWREAEAE 82
A EP P GP L PGEPG A E E P + G A AA +EA
Sbjct: 4 AAEPEGVAPGPQGPPEVPAPLAERPGEPGAAGGEAEGPEGSEGAEEAPRGAAAVKEAGGG 63
Query: 83 AAAAGGEQEAQATAAA-GEGDNGPGLQGPSREPPLADNLYDEDDDDEGEEEEEAAAAAIG 141
G E EA+ T A GE + G + P ++ G ++ E A+ G
Sbjct: 64 GPDRGPEAEARGTRGAHGETEAEEGAPEGAEVP-------QGGEETSGAQQVEGASPGRG 116
Score = 33.9 bits (76), Expect = 0.57
Identities = 35/132 (26%), Positives = 52/132 (39%), Gaps = 5/132 (3%)
Query: 5 AALALQPGGSPSAAGADREAASSPA--GEPLRKRPRRDGPGLERSPGEPGGAAPEREVPA 62
AA + GG G + EA + GE + +G + + GE A + E +
Sbjct: 54 AAAVKEAGGGGPDRGPEAEARGTRGAHGETEAEEGAPEGAEVPQG-GEETSGAQQVEGAS 112
Query: 63 AARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGD-NGPGLQGPSREPPLADNLY 121
RG G RE E ++AA ++EA+ EG +G E PL DN+
Sbjct: 113 PGRGAQGEPRGEAQREPE-DSAAPERQEEAEQRPEVPEGSASGEAGDSVDAEGPLGDNIE 171
Query: 122 DEDDDDEGEEEE 133
E + E E
Sbjct: 172 AEGPAGDSVEAE 183
Score = 33.5 bits (75), Expect = 0.74
Identities = 35/134 (26%), Positives = 50/134 (37%), Gaps = 17/134 (12%)
Query: 11 PGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAARG--CP 68
P G +GA + +SP G + PR + +R P + AAPER+ A R
Sbjct: 96 PQGGEETSGAQQVEGASP-GRGAQGEPRGEA---QREPED--SAAPERQEEAEQRPEVPE 149
Query: 69 GAAAAALWREAEAEA---------AAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADN 119
G+A+ +AE AG EA+ GP E PL DN
Sbjct: 150 GSASGEAGDSVDAEGPLGDNIEAEGPAGDSVEAEGRVGDSVDAEGPAGDSVDAEGPLGDN 209
Query: 120 LYDEDDDDEGEEEE 133
+ E + + E
Sbjct: 210 IQAEGPAGDSVDAE 223
Score = 32.0 bits (71), Expect = 2.2
Identities = 37/142 (26%), Positives = 52/142 (36%), Gaps = 15/142 (10%)
Query: 8 ALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGL----ERSPGEPGGAAPEREVPAA 63
+L P A A SP + PG+ E +PG+ A E V
Sbjct: 303 SLSPQAEAIEVAAGESAGRSPGELAWDAAEEAEVPGVKGSEEAAPGDARADAGEDRVGDG 362
Query: 64 ARGCPGAAAAALWREAEA--EAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNLY 121
+ PG R E E AAGGE+E+ ++ GE G E L+++L
Sbjct: 363 PQQEPGEDEERRERSPEGPREEEAAGGEEESPDSSPHGEASRG----AAEPEAQLSNHL- 417
Query: 122 DEDDDDEGEEEEEAAAAAIGYR 143
+EG E AA + R
Sbjct: 418 ----AEEGPAEGSGEAARVNGR 435
>gi|239754674 PREDICTED: hypothetical protein [Homo sapiens]
Length = 480
Score = 42.0 bits (97), Expect = 0.002
Identities = 35/113 (30%), Positives = 47/113 (41%), Gaps = 11/113 (9%)
Query: 12 GGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPA-AARGCPGA 70
GG P + + ++PA +P P P R PG GA+ E + + AAR P
Sbjct: 191 GGRPKSQPPLPQETAAPAPQPGPTAP----PARVREPGRAEGASREPRLRSRAARPPPAP 246
Query: 71 AAAALWREAEAEAAAA------GGEQEAQATAAAGEGDNGPGLQGPSREPPLA 117
AL R + + AA GGE+ A A G G PG G + P A
Sbjct: 247 GPGALSRASRSRAAGRPGPGFHGGEKAAAPRAPGGGGGRNPGALGRAAPPSRA 299
Score = 38.9 bits (89), Expect = 0.018
Identities = 34/127 (26%), Positives = 45/127 (35%), Gaps = 20/127 (15%)
Query: 8 ALQPGGSPSAAGADREAASSPAGEP--------LRKRPRRDGPGLERSPGEPGGAAPERE 59
A +P +P R + S AG P PR G G R+PG G AAP
Sbjct: 239 AARPPPAPGPGALSRASRSRAAGRPGPGFHGGEKAAAPRAPGGGGGRNPGALGRAAPPSR 298
Query: 60 VPAAARGCPGAAAAALWR-------EAEAEAAAAGGE-----QEAQATAAAGEGDNGPGL 107
A G G A L R ++ A + GE + + GEG+
Sbjct: 299 ARQDAWGLSGCATVGLRRGDCDRAGSSQPPATSGNGERCRFCRRRRRRGGGGEGEGTHAT 358
Query: 108 QGPSREP 114
GP+ P
Sbjct: 359 HGPASPP 365
>gi|21264565 AT rich interactive domain 1A isoform a [Homo sapiens]
Length = 2285
Score = 42.0 bits (97), Expect = 0.002
Identities = 38/109 (34%), Positives = 50/109 (45%), Gaps = 12/109 (11%)
Query: 12 GGSPSAAGADR-EAASSPA-----GEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAAR 65
GG PSAAG + ++P P R + PG + S G G A + A++
Sbjct: 276 GGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYSGGPQDGGAGKGPADMASQ 335
Query: 66 GCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREP 114
C GAAAAA A AAA+GG Q+ A G +G G Q +R P
Sbjct: 336 -CWGAAAAAA-----AAAAASGGAQQRSHHAPMSPGSSGGGGQPLARTP 378
Score = 32.3 bits (72), Expect = 1.6
Identities = 19/52 (36%), Positives = 25/52 (48%), Gaps = 3/52 (5%)
Query: 78 EAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNLYDEDDDDEG 129
EA EAAAA + + AAAG+ GP + P PL L D + + G
Sbjct: 34 EAGGEAAAAAAAERGEMKAAAGQESEGPAVGPPQ---PLGKELQDGAESNGG 82
Score = 30.0 bits (66), Expect = 8.2
Identities = 21/67 (31%), Positives = 26/67 (38%), Gaps = 6/67 (8%)
Query: 8 ALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSP-----GEPGGAAPEREVPA 62
AL PG S S + + S+PA P PG+ R P G P A R P
Sbjct: 656 ALSPGVSTSGISSSQGEQSNPAQSPFSPHTSPHLPGI-RGPSPSPVGSPASVAQSRSGPL 714
Query: 63 AARGCPG 69
+ PG
Sbjct: 715 SPAAVPG 721
>gi|21264575 AT rich interactive domain 1A isoform b [Homo sapiens]
Length = 2068
Score = 42.0 bits (97), Expect = 0.002
Identities = 38/109 (34%), Positives = 50/109 (45%), Gaps = 12/109 (11%)
Query: 12 GGSPSAAGADR-EAASSPA-----GEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAAR 65
GG PSAAG + ++P P R + PG + S G G A + A++
Sbjct: 276 GGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYSGGPQDGGAGKGPADMASQ 335
Query: 66 GCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREP 114
C GAAAAA A AAA+GG Q+ A G +G G Q +R P
Sbjct: 336 -CWGAAAAAA-----AAAAASGGAQQRSHHAPMSPGSSGGGGQPLARTP 378
Score = 32.3 bits (72), Expect = 1.6
Identities = 19/52 (36%), Positives = 25/52 (48%), Gaps = 3/52 (5%)
Query: 78 EAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNLYDEDDDDEG 129
EA EAAAA + + AAAG+ GP + P PL L D + + G
Sbjct: 34 EAGGEAAAAAAAERGEMKAAAGQESEGPAVGPPQ---PLGKELQDGAESNGG 82
Score = 30.0 bits (66), Expect = 8.2
Identities = 21/67 (31%), Positives = 26/67 (38%), Gaps = 6/67 (8%)
Query: 8 ALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSP-----GEPGGAAPEREVPA 62
AL PG S S + + S+PA P PG+ R P G P A R P
Sbjct: 656 ALSPGVSTSGISSSQGEQSNPAQSPFSPHTSPHLPGI-RGPSPSPVGSPASVAQSRSGPL 714
Query: 63 AARGCPG 69
+ PG
Sbjct: 715 SPAAVPG 721
>gi|122937267 lemur tyrosine kinase 3 [Homo sapiens]
Length = 1489
Score = 42.0 bits (97), Expect = 0.002
Identities = 48/153 (31%), Positives = 60/153 (39%), Gaps = 35/153 (22%)
Query: 4 EAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLER---SPGEPGGAAPEREV 60
E A +PG S AG D A S G+P +P R GP + R G P G + + +
Sbjct: 1200 EVAPEGEPGAPDSRAGGD--TALSGDGDP--PKPERKGPEMPRLFLDLGPPQGNSEQIKA 1255
Query: 61 ----------PAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGP 110
P PG E A+A AAGGE G G GP
Sbjct: 1256 RLSRLSLALPPLTLTPFPGPGPRRPPWEG-ADAGAAGGEA------------GGAGAPGP 1302
Query: 111 SREPPLADNLYDEDDDDEGEEEEEAAAAAIGYR 143
+ E DED+D+E +EE A AA G R
Sbjct: 1303 AEEDG-----EDEDEDEEEDEEAAAPGAAAGPR 1330
>gi|154759255 collagen, type XXVIII precursor [Homo sapiens]
Length = 1125
Score = 42.0 bits (97), Expect = 0.002
Identities = 39/106 (36%), Positives = 45/106 (42%), Gaps = 8/106 (7%)
Query: 11 PGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAARGCPGA 70
P GSP A G ++ G+ RP GP PG+PG PE VP RG PG
Sbjct: 350 PYGSPGAPGIGQQGIKGERGQ--EGRPGAPGPIGVGEPGQPGPRGPE-GVP-GERGLPGE 405
Query: 71 AAAALWREAEAEAAAAGGEQEAQATAAAGE-GDNGP-GLQGPSREP 114
E +E G Q Q + GE GD GP G QGP P
Sbjct: 406 GFPGPKGEKGSEGPT--GPQGLQGLSIKGEKGDIGPVGPQGPMGIP 449
>gi|98985810 alpha 1 type XI collagen isoform B preproprotein [Homo
sapiens]
Length = 1818
Score = 40.8 bits (94), Expect = 0.005
Identities = 37/118 (31%), Positives = 49/118 (41%), Gaps = 13/118 (11%)
Query: 11 PGGSPSAAGADREAASSPAGEP--LRKRPRRDGP----GLERSPGEPGGAAPE-REVPAA 63
P G P G+ E S+ P L RP GP G + +PGE G P R+
Sbjct: 1061 PQGPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQG 1120
Query: 64 ARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGP----GLQGPSREPPLA 117
G PG A A + + G + Q + +G+NGP GLQGP P +A
Sbjct: 1121 PVGLPGPAGPAGSPGEDGDKGEIG--EPGQKGSKGDKGENGPPGPPGLQGPVGAPGIA 1176
Score = 40.0 bits (92), Expect = 0.008
Identities = 38/113 (33%), Positives = 48/113 (42%), Gaps = 21/113 (18%)
Query: 11 PGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERS----PGEPGGAAPEREV----PA 62
P G+P G + P GEP +DG G ++ PG+PG P E P
Sbjct: 1316 PKGNPGPVGFPGDPG--PPGEP--GPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPP 1371
Query: 63 AARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGP-GLQGPSREP 114
RG PGAA AE G + EA A G+ GP G QGP+ +P
Sbjct: 1372 GKRGPPGAAG------AEGRQGEKGAKGEAGAEGPPGK--TGPVGPQGPAGKP 1416
Score = 32.7 bits (73), Expect = 1.3
Identities = 42/137 (30%), Positives = 52/137 (37%), Gaps = 12/137 (8%)
Query: 13 GSPSAAGADREAASSPAGEPLRKRPRRDG-PGLERSPGEPGGAAPEREV-PAAARGCPGA 70
G P G + PAG LR P G PG + +PG GG P+ P + G G+
Sbjct: 1021 GDPGPQGISGK--DGPAG--LRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGERGS 1076
Query: 71 AAAALWREAEAEAAAAGGEQEAQATAAAGE-GDNGP----GLQGPSREP-PLADNLYDED 124
A A G A A GE G GP G+QGP P P +
Sbjct: 1077 AGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGE 1136
Query: 125 DDDEGEEEEEAAAAAIG 141
D D+GE E + G
Sbjct: 1137 DGDKGEIGEPGQKGSKG 1153
>gi|98985808 alpha 1 type XI collagen isoform C preproprotein [Homo
sapiens]
Length = 1767
Score = 40.8 bits (94), Expect = 0.005
Identities = 37/118 (31%), Positives = 49/118 (41%), Gaps = 13/118 (11%)
Query: 11 PGGSPSAAGADREAASSPAGEP--LRKRPRRDGP----GLERSPGEPGGAAPE-REVPAA 63
P G P G+ E S+ P L RP GP G + +PGE G P R+
Sbjct: 1010 PQGPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQG 1069
Query: 64 ARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGP----GLQGPSREPPLA 117
G PG A A + + G + Q + +G+NGP GLQGP P +A
Sbjct: 1070 PVGLPGPAGPAGSPGEDGDKGEIG--EPGQKGSKGDKGENGPPGPPGLQGPVGAPGIA 1125
Score = 40.0 bits (92), Expect = 0.008
Identities = 38/113 (33%), Positives = 48/113 (42%), Gaps = 21/113 (18%)
Query: 11 PGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERS----PGEPGGAAPEREV----PA 62
P G+P G + P GEP +DG G ++ PG+PG P E P
Sbjct: 1265 PKGNPGPVGFPGDPG--PPGEP--GPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPP 1320
Query: 63 AARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGP-GLQGPSREP 114
RG PGAA AE G + EA A G+ GP G QGP+ +P
Sbjct: 1321 GKRGPPGAAG------AEGRQGEKGAKGEAGAEGPPGK--TGPVGPQGPAGKP 1365
Score = 32.7 bits (73), Expect = 1.3
Identities = 42/137 (30%), Positives = 52/137 (37%), Gaps = 12/137 (8%)
Query: 13 GSPSAAGADREAASSPAGEPLRKRPRRDG-PGLERSPGEPGGAAPEREV-PAAARGCPGA 70
G P G + PAG LR P G PG + +PG GG P+ P + G G+
Sbjct: 970 GDPGPQGISGK--DGPAG--LRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGERGS 1025
Query: 71 AAAALWREAEAEAAAAGGEQEAQATAAAGE-GDNGP----GLQGPSREP-PLADNLYDED 124
A A G A A GE G GP G+QGP P P +
Sbjct: 1026 AGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGE 1085
Query: 125 DDDEGEEEEEAAAAAIG 141
D D+GE E + G
Sbjct: 1086 DGDKGEIGEPGQKGSKG 1102
>gi|98985806 alpha 1 type XI collagen isoform A preproprotein [Homo
sapiens]
Length = 1806
Score = 40.8 bits (94), Expect = 0.005
Identities = 37/118 (31%), Positives = 49/118 (41%), Gaps = 13/118 (11%)
Query: 11 PGGSPSAAGADREAASSPAGEP--LRKRPRRDGP----GLERSPGEPGGAAPE-REVPAA 63
P G P G+ E S+ P L RP GP G + +PGE G P R+
Sbjct: 1049 PQGPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQG 1108
Query: 64 ARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGP----GLQGPSREPPLA 117
G PG A A + + G + Q + +G+NGP GLQGP P +A
Sbjct: 1109 PVGLPGPAGPAGSPGEDGDKGEIG--EPGQKGSKGDKGENGPPGPPGLQGPVGAPGIA 1164
Score = 40.0 bits (92), Expect = 0.008
Identities = 38/113 (33%), Positives = 48/113 (42%), Gaps = 21/113 (18%)
Query: 11 PGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERS----PGEPGGAAPEREV----PA 62
P G+P G + P GEP +DG G ++ PG+PG P E P
Sbjct: 1304 PKGNPGPVGFPGDPG--PPGEP--GPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPP 1359
Query: 63 AARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGP-GLQGPSREP 114
RG PGAA AE G + EA A G+ GP G QGP+ +P
Sbjct: 1360 GKRGPPGAAG------AEGRQGEKGAKGEAGAEGPPGK--TGPVGPQGPAGKP 1404
Score = 32.7 bits (73), Expect = 1.3
Identities = 42/137 (30%), Positives = 52/137 (37%), Gaps = 12/137 (8%)
Query: 13 GSPSAAGADREAASSPAGEPLRKRPRRDG-PGLERSPGEPGGAAPEREV-PAAARGCPGA 70
G P G + PAG LR P G PG + +PG GG P+ P + G G+
Sbjct: 1009 GDPGPQGISGK--DGPAG--LRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGERGS 1064
Query: 71 AAAALWREAEAEAAAAGGEQEAQATAAAGE-GDNGP----GLQGPSREP-PLADNLYDED 124
A A G A A GE G GP G+QGP P P +
Sbjct: 1065 AGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGE 1124
Query: 125 DDDEGEEEEEAAAAAIG 141
D D+GE E + G
Sbjct: 1125 DGDKGEIGEPGQKGSKG 1141
>gi|4503257 death-domain associated protein isoform a [Homo sapiens]
Length = 740
Score = 40.8 bits (94), Expect = 0.005
Identities = 34/117 (29%), Positives = 51/117 (43%), Gaps = 12/117 (10%)
Query: 27 SPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPA--AARGCPGAAAAALWREAEAEAA 84
S GE ++R R G S P + E P+ A++GCP A+ A E + E+
Sbjct: 386 SEEGERKKRRARLQGTS-SHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESD 444
Query: 85 AAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNLYDEDDDDEGEEEEEAAAAAIG 141
E+E + A + + E L ++DD+E +EEEEAAA G
Sbjct: 445 EEEEEEEEEEEEEATDSEE---------EEDLEQMQEGQEDDEEEDEEEEAAAGKDG 492
>gi|215422388 death-domain associated protein isoform a [Homo
sapiens]
Length = 740
Score = 40.8 bits (94), Expect = 0.005
Identities = 34/117 (29%), Positives = 51/117 (43%), Gaps = 12/117 (10%)
Query: 27 SPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPA--AARGCPGAAAAALWREAEAEAA 84
S GE ++R R G S P + E P+ A++GCP A+ A E + E+
Sbjct: 386 SEEGERKKRRARLQGTS-SHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESD 444
Query: 85 AAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNLYDEDDDDEGEEEEEAAAAAIG 141
E+E + A + + E L ++DD+E +EEEEAAA G
Sbjct: 445 EEEEEEEEEEEEEATDSEE---------EEDLEQMQEGQEDDEEEDEEEEAAAGKDG 492
>gi|215422366 death-domain associated protein isoform b [Homo
sapiens]
Length = 752
Score = 40.8 bits (94), Expect = 0.005
Identities = 34/117 (29%), Positives = 51/117 (43%), Gaps = 12/117 (10%)
Query: 27 SPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPA--AARGCPGAAAAALWREAEAEAA 84
S GE ++R R G S P + E P+ A++GCP A+ A E + E+
Sbjct: 398 SEEGERKKRRARLQGTS-SHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESD 456
Query: 85 AAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNLYDEDDDDEGEEEEEAAAAAIG 141
E+E + A + + E L ++DD+E +EEEEAAA G
Sbjct: 457 EEEEEEEEEEEEEATDSEE---------EEDLEQMQEGQEDDEEEDEEEEAAAGKDG 504
>gi|30795231 brain abundant, membrane attached signal protein 1
[Homo sapiens]
Length = 227
Score = 40.8 bits (94), Expect = 0.005
Identities = 41/141 (29%), Positives = 56/141 (39%), Gaps = 25/141 (17%)
Query: 12 GGSPSAAGADREAASSPAGEPL-----RKRPRRDGPG-LERSPGEPGGAAPEREVPAAA- 64
G + G +E+ A EP +++P +D G E GE AA + E P A
Sbjct: 28 GAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEP 87
Query: 65 RGCPGAAAA------ALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLAD 118
GAA A A +E A AAGGE A AAA ++ G
Sbjct: 88 EKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAG--------- 138
Query: 119 NLYDEDDDDEGEEEEEAAAAA 139
+E +EGE ++ A AA
Sbjct: 139 ---EEPSKEEGEPKKTEAPAA 156
Score = 30.4 bits (67), Expect = 6.3
Identities = 31/106 (29%), Positives = 44/106 (41%), Gaps = 18/106 (16%)
Query: 4 EAALALQPGGSP--SAAGADREAASSPAGEPLR---------KRPRRDG-PGLERSPGEP 51
EA A + +P SAA A E S GEP + + + DG P + PG
Sbjct: 118 EAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSS 177
Query: 52 GGAAPEREVPAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAA 97
A +E PAA A + +A+ AA+A + +A AA
Sbjct: 178 EAAPSSKETPAATE------APSSTPKAQGPAASAEEPKPVEAPAA 217
>gi|165905613 ring finger and KH domain containing 1 [Homo sapiens]
Length = 651
Score = 40.8 bits (94), Expect = 0.005
Identities = 39/111 (35%), Positives = 46/111 (41%), Gaps = 21/111 (18%)
Query: 15 PSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAARGCPGAAAAA 74
P AAGA R SS AG P R P L EPGG E+P + RG P A
Sbjct: 497 PPAAGARR---SSGAGTP------RHSPTLP----EPGGL--RLELPLSRRGAPDPVGAL 541
Query: 75 LWREAEAEAAAAGGEQEAQAT------AAAGEGDNGPGLQGPSREPPLADN 119
WR + + GG + AT AAA G SR+PP A +
Sbjct: 542 SWRPPQGPVSFPGGAAFSTATSLPSSPAAAACAPLDSGASENSRKPPSASS 592
>gi|30061556 SRY (sex determining region Y)-box 3 [Homo sapiens]
Length = 446
Score = 40.0 bits (92), Expect = 0.008
Identities = 39/105 (37%), Positives = 44/105 (41%), Gaps = 9/105 (8%)
Query: 20 ADREAASSPAGEP-LRKRPRRDGPGLERSPGEPGGAAPEREVPAAARGCPGAAAAALWRE 78
A + SSP P L R D GL+ SP P GA V AAA G A
Sbjct: 282 AQPPSMSSPPPPPALPPMHRYDMAGLQYSPMMPPGAQSYMNVAAAAAAASGYGGMA--PS 339
Query: 79 AEAEAAAAGGEQEAQATAAAGE------GDNGPGLQGPSREPPLA 117
A A AAAA G+Q A A AAA G G ++ PP A
Sbjct: 340 ATAAAAAAYGQQPATAAAAAAAAAAMSLGPMGSVVKSEPSSPPPA 384
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.134 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,727,098
Number of Sequences: 37866
Number of extensions: 1943645
Number of successful extensions: 12265
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 91
Number of HSP's successfully gapped in prelim test: 583
Number of HSP's that attempted gapping in prelim test: 10243
Number of HSP's gapped (non-prelim): 2176
length of query: 747
length of database: 18,247,518
effective HSP length: 110
effective length of query: 637
effective length of database: 14,082,258
effective search space: 8970398346
effective search space used: 8970398346
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.