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Search of human proteins with 7657261
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo
sapiens]
(1499 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens] 2978 0.0
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa... 1769 0.0
gi|239752520 PREDICTED: similar to Rap guanine nucleotide exchan... 1586 0.0
gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Hom... 168 3e-41
gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof... 167 7e-41
gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof... 167 7e-41
gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1 [... 159 3e-38
gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b ... 155 3e-37
gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [... 155 3e-37
gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a ... 155 3e-37
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 102 2e-21
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom... 102 2e-21
gi|22749129 RasGEF domain family, member 1B [Homo sapiens] 101 5e-21
gi|40255197 RasGEF domain family, member 1C [Homo sapiens] 101 5e-21
gi|117168263 RasGEF domain family, member 1A [Homo sapiens] 96 3e-19
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 92 5e-18
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 92 5e-18
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa... 92 5e-18
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo... 91 1e-17
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 90 2e-17
gi|15529996 son of sevenless homolog 1 [Homo sapiens] 88 5e-17
gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ... 86 3e-16
gi|154689780 son of sevenless homolog 2 [Homo sapiens] 79 4e-14
gi|93102367 ral guanine nucleotide dissociation stimulator-like ... 74 1e-12
gi|24307909 ral guanine nucleotide dissociation stimulator isofo... 74 1e-12
gi|108796058 ral guanine nucleotide dissociation stimulator isof... 74 1e-12
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 73 2e-12
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 73 2e-12
gi|13376349 PDZ domain containing 7 [Homo sapiens] 73 2e-12
gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo sapi... 70 2e-11
>gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]
Length = 1499
Score = 2978 bits (7721), Expect = 0.0
Identities = 1499/1499 (100%), Positives = 1499/1499 (100%)
Query: 1 MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLS 60
MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLS
Sbjct: 1 MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLS 60
Query: 61 DIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTD 120
DIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTD
Sbjct: 61 DIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTD 120
Query: 121 DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS 180
DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS
Sbjct: 121 DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS 180
Query: 181 VEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEK 240
VEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEK
Sbjct: 181 VEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEK 240
Query: 241 NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL 300
NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL
Sbjct: 241 NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL 300
Query: 301 TYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENN 360
TYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENN
Sbjct: 301 TYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENN 360
Query: 361 LEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGS 420
LEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGS
Sbjct: 361 LEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGS 420
Query: 421 KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE 480
KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE
Sbjct: 421 KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE 480
Query: 481 KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT 540
KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT
Sbjct: 481 KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT 540
Query: 541 RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS 600
RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS
Sbjct: 541 RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS 600
Query: 601 ATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPE 660
ATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPE
Sbjct: 601 ATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPE 660
Query: 661 GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVE 720
GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVE
Sbjct: 661 GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVE 720
Query: 721 VATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETN 780
VATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETN
Sbjct: 721 VATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETN 780
Query: 781 QLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDL 840
QLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDL
Sbjct: 781 QLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDL 840
Query: 841 QDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMI 900
QDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMI
Sbjct: 841 QDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMI 900
Query: 901 AKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSS 960
AKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSS
Sbjct: 901 AKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSS 960
Query: 961 FLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKNPGDKKPVKSE 1020
FLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKNPGDKKPVKSE
Sbjct: 961 FLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKNPGDKKPVKSE 1020
Query: 1021 TSPVAPRAGSQQKAQSLPQPQQQPPPAHKINQGLQVPAVSLYPSRKKVPVKDLPPFGINS 1080
TSPVAPRAGSQQKAQSLPQPQQQPPPAHKINQGLQVPAVSLYPSRKKVPVKDLPPFGINS
Sbjct: 1021 TSPVAPRAGSQQKAQSLPQPQQQPPPAHKINQGLQVPAVSLYPSRKKVPVKDLPPFGINS 1080
Query: 1081 PQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDNF 1140
PQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDNF
Sbjct: 1081 PQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDNF 1140
Query: 1141 SDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVETNLGMGRMERRTMIEPDQY 1200
SDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVETNLGMGRMERRTMIEPDQY
Sbjct: 1141 SDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVETNLGMGRMERRTMIEPDQY 1200
Query: 1201 SLGSYAPMSEGRGLYATATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNI 1260
SLGSYAPMSEGRGLYATATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNI
Sbjct: 1201 SLGSYAPMSEGRGLYATATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNI 1260
Query: 1261 QTIQHQRSWETLPFGHTHFDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQA 1320
QTIQHQRSWETLPFGHTHFDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQA
Sbjct: 1261 QTIQHQRSWETLPFGHTHFDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQA 1320
Query: 1321 QSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAESSSLTSVTTEETKPVPMPAHIAV 1380
QSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAESSSLTSVTTEETKPVPMPAHIAV
Sbjct: 1321 QSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAESSSLTSVTTEETKPVPMPAHIAV 1380
Query: 1381 ASSTTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPARKPPDYNVALQRSRMVAR 1440
ASSTTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPARKPPDYNVALQRSRMVAR
Sbjct: 1381 ASSTTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPARKPPDYNVALQRSRMVAR 1440
Query: 1441 SSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFSTEEDEDEQVSAV 1499
SSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFSTEEDEDEQVSAV
Sbjct: 1441 SSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFSTEEDEDEQVSAV 1499
>gi|54633319 PDZ domain-containing guanine nucleotide exchange factor
I [Homo sapiens]
Length = 1601
Score = 1769 bits (4582), Expect = 0.0
Identities = 958/1494 (64%), Positives = 1120/1494 (74%), Gaps = 71/1494 (4%)
Query: 20 SLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEAGDMDLSGLP 79
SLPAD TK+HLT++ HPQVTHVSSS SGCSI SDSGSSSLSDIYQATESE GD+DL+ LP
Sbjct: 165 SLPADLTKMHLTENPHPQVTHVSSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLP 224
Query: 80 ETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANM 139
E VDSEDD++E++ +DPL RD+VR+CLEK+P D+TDDDIEQLLEFMHQLPAFANM
Sbjct: 225 EGPVDSEDDEEEDEEIDRTDPLQGRDLVRECLEKEPADKTDDDIEQLLEFMHQLPAFANM 284
Query: 140 TMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSF 199
TMSVRRELC+VM+F VVE+AG I+L DG+ELDSW VILNG+VE+++PDGK E L MGNSF
Sbjct: 285 TMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTVEISHPDGKVENLFMGNSF 344
Query: 200 GVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRE 259
G++PT+DK+YM G++RTKVDDCQFVCIAQQDY RILN VEKN KVEEEGEIVMV EHRE
Sbjct: 345 GITPTLDKQYMHGIVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRE 404
Query: 260 LDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEW 319
LDR+GTRKGHIVIK T ERL MHL+EEHS+VDPT+IEDFLLTYRTFL SP++VG KLLEW
Sbjct: 405 LDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEW 464
Query: 320 FNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAA 379
F SLRDKVTR+VLLWVNNHFNDFEGDPAMTRFLEEFE NLE KM GHLRLLNIACAA
Sbjct: 465 FKIDSLRDKVTRIVLLWVNNHFNDFEGDPAMTRFLEEFEKNLEDTKMNGHLRLLNIACAA 524
Query: 380 KAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQ 439
KAK R + L K SRE+PL F L GGSEKGFGIFV+ V+ GSKA ++GLKRGDQI+EVNGQ
Sbjct: 525 KAKWRQVVLQKASRESPLQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQ 584
Query: 440 NFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEEKRNGAPHLPKIGDIKKASR 499
NFENI KA+EILRNNTHL++TVKTN+FVFKELL R +E++++G PH+PKI + KK++R
Sbjct: 585 NFENITFMKAVEILRNNTHLALTVKTNIFVFKELLFR-TEQEKSGVPHIPKIAE-KKSNR 642
Query: 500 YSIPDLAVDVEQVIGLEKVNKKSKANTV-GGRNKLKKILDKTRISILPQKPYNDIGIGQS 558
+SI + D+EQ EK +KK KANTV GGRNK++KILDKTR SILP K ++D G+ QS
Sbjct: 643 HSIQHVPGDIEQT-SQEKGSKKVKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQS 701
Query: 559 QDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFSATPDLPDQVLRVFKADQQ 618
QDDSIVG R +H +P+ GTLSSS+PDLLQ +LDFS D+PDQV+RVFK DQQ
Sbjct: 702 QDDSIVGTRHCRHSLAIMPIPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKVDQQ 761
Query: 619 SRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADR 678
S YI+ISKDTTAKEVV A+ EF +T D YSLCEVSVTPEGVIKQRRLPDQ SKLADR
Sbjct: 762 SCYIIISKDTTAKEVVFHAVHEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADR 821
Query: 679 IQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEP 738
IQL+GRYYLKNNMETETLCSDEDAQEL++ESQ+S+LQLST+EVATQLSMR+F+LFRNIEP
Sbjct: 822 IQLNGRYYLKNNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEP 881
Query: 739 TEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHC 798
TEYIDDLFKL SKT +LKRFE+++NQETFWVASEIL E NQLKRMKIIKHFIKIALHC
Sbjct: 882 TEYIDDLFKLNSKTGNTHLKRFEDIVNQETFWVASEILTEANQLKRMKIIKHFIKIALHC 941
Query: 799 RECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLN 858
RECKNFNSMFAIISGLNLA VARLR TWEKLP+KYEK QDLQD+FDPSRNMAKYRN+L+
Sbjct: 942 RECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNILS 1001
Query: 859 SQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMASVNMDPA 918
SQ++QPPIIPLFPV+KKD+TFLHEGNDSKVDGLVNFEKLRMI+KEIR V RM S NMDPA
Sbjct: 1002 SQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGLVNFEKLRMISKEIRQVVRMTSANMDPA 1061
Query: 919 LMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVK 978
+MFR R SLSQGSTN+ +LDV Q G HKKR RRSS LNAKKLYEDAQMARKVK
Sbjct: 1062 MMFRQR--------SLSQGSTNSNMLDV-QGGAHKKRARRSSLLNAKKLYEDAQMARKVK 1112
Query: 979 QYLSNLELEMDEESLQTLSLQCEPATNTLPKNPGDKKPVK-SETSPVAPRAGSQQKAQSL 1037
QYLS+L++E DEE Q +SLQ EPA TL KN +K+ K SE SPV R+ Q L
Sbjct: 1113 QYLSSLDVETDEEKFQMMSLQWEPAYGTLTKNLSEKRSAKSSEMSPVPMRSAGQTTKAHL 1172
Query: 1038 PQPQQQPPPAHKINQGLQVPAVSLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLE 1097
QP H+++Q LQVPAV+L+P RKK KD P + PQ K+L +EE S
Sbjct: 1173 HQP-------HRVSQVLQVPAVNLHPIRKKGQTKD-PALNTSLPQ---KVLGTTEEIS-- 1219
Query: 1098 RHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDNFSDSGHSEISSRSSIVSN 1157
KK EDTIS ASS SSPP SPQ SP KGYTL PS DN SDS HSEISSRSSIVSN
Sbjct: 1220 -GKKHTEDTISVASSLHSSPPASPQGSPHKGYTLIPSAKSDNLSDSSHSEISSRSSIVSN 1278
Query: 1158 SSFDSVPVSLHDERRQRHSVSIVETNLGMGRMERRTMIEPDQYSLGSYAPMSEG-----R 1212
S DS+ +L DER ++++ E+ + + E + +G ++ G
Sbjct: 1279 CSVDSMSAALQDERCSSQALAVPESTGALEKTEHAS-------GIGDHSQHGPGWTLLKP 1331
Query: 1213 GLYATATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWETL 1272
L V SS S EE+SQ + ++AADSGRGSWTSCSS SHDN Q++ + +SW+ L
Sbjct: 1332 SLIKCLAVSSSVSNEEISQ---EHIIIEAADSGRGSWTSCSSSSHDNFQSLPNPKSWDFL 1388
Query: 1273 -PFGHTHFDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQAQSRASWASSTG 1331
+ HTH D DP A D +S + Q + SLE R SW SS+
Sbjct: 1389 NSYRHTHLD---DPI---AEVEPTDSEPYSCSKSCSRTCGQCKGSLE----RKSWTSSSS 1438
Query: 1332 YWGEDSEGDTGTIKRRGGKDVSIEAESSSLTSVTTEETKPVPMPAHIAVASSTTKGLIA- 1390
+ E + GT+KRR ES+ S + K P + V SST KGLI
Sbjct: 1439 L-SDTYEPNYGTVKRR-------VLESTPAESSEGLDPKDATDPVYKTVTSSTEKGLIVY 1490
Query: 1391 -----RKEGRYREPPPTPPGYIGIPITDFPEGHSHPARKPPDYNVALQRSRMVARSSDTA 1445
+K+ RYREPPPTPPGY+GI + D EG H KPPDY+VA+QRS+M+ S
Sbjct: 1491 CVTSPKKDDRYREPPPTPPGYLGISLADLKEG-PHTHLKPPDYSVAVQRSKMMHNSLSRL 1549
Query: 1446 GPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFSTEEDEDEQVSAV 1499
P+S+ S+ V +PQ H P+L +E DE+EQVSAV
Sbjct: 1550 PPASLSSNLVACVPSKIVTQPQRHNLQPFHPKLGDVTDA--DSEADENEQVSAV 1601
Score = 32.0 bits (71), Expect = 4.6
Identities = 23/78 (29%), Positives = 39/78 (50%), Gaps = 5/78 (6%)
Query: 108 RDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVER-AGTIVLND 166
R L K P +RT +D+ + ++H + +N+ +L + A ER +G VL
Sbjct: 10 RQALRKKPPERTPEDLNTIYSYLHGMEILSNLR---EHQLRLMSARARYERYSGNQVLFC 66
Query: 167 GEEL-DSWSVILNGSVEV 183
E + W ++L+GSV V
Sbjct: 67 SETIARCWYILLSGSVLV 84
>gi|239752520 PREDICTED: similar to Rap guanine nucleotide exchange
factor 2, partial [Homo sapiens]
Length = 803
Score = 1586 bits (4106), Expect = 0.0
Identities = 803/803 (100%), Positives = 803/803 (100%)
Query: 1 MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLS 60
MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLS
Sbjct: 1 MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLS 60
Query: 61 DIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTD 120
DIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTD
Sbjct: 61 DIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTD 120
Query: 121 DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS 180
DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS
Sbjct: 121 DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS 180
Query: 181 VEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEK 240
VEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEK
Sbjct: 181 VEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEK 240
Query: 241 NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL 300
NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL
Sbjct: 241 NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL 300
Query: 301 TYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENN 360
TYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENN
Sbjct: 301 TYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENN 360
Query: 361 LEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGS 420
LEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGS
Sbjct: 361 LEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGS 420
Query: 421 KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE 480
KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE
Sbjct: 421 KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE 480
Query: 481 KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT 540
KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT
Sbjct: 481 KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT 540
Query: 541 RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS 600
RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS
Sbjct: 541 RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS 600
Query: 601 ATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPE 660
ATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPE
Sbjct: 601 ATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPE 660
Query: 661 GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVE 720
GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVE
Sbjct: 661 GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVE 720
Query: 721 VATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETN 780
VATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETN
Sbjct: 721 VATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETN 780
Query: 781 QLKRMKIIKHFIKIALHCRECKN 803
QLKRMKIIKHFIKIALHCRECKN
Sbjct: 781 QLKRMKIIKHFIKIALHCRECKN 803
>gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Homo
sapiens]
Length = 730
Score = 168 bits (426), Expect = 3e-41
Identities = 105/267 (39%), Positives = 157/267 (58%), Gaps = 9/267 (3%)
Query: 643 VTATPDQYS---LCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSD 699
V A QY+ L V++T G K P+ L ++ ++ SGR Y+ +TL
Sbjct: 421 VVAEKIQYAEEDLALVAITFSGE-KHELQPNDLV-ISKSLEASGRIYVYRKDLADTLNPF 478
Query: 700 EDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLR-SKTSCANLK 758
+ +E + S + +L ++T ++A +L ++ LF +I E I F + S ANL
Sbjct: 479 AENEESQQRS-MRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLS 537
Query: 759 RFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAP 818
+ N+ WVA+EIL + KR++++K FIKIA HC+ +N NS FAI+ GLN A
Sbjct: 538 LLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTAS 597
Query: 819 VARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLT 878
V+RL TWEK+P K++KLF +L+ L DPS N YR+ + ++PP IP P++ KD+T
Sbjct: 598 VSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAF--KKMKPPKIPFMPLLLKDVT 655
Query: 879 FLHEGNDSKVDGLVNFEKLRMIAKEIR 905
F+HEGN + +D LVNFEKL MIA +R
Sbjct: 656 FIHEGNKTFLDNLVNFEKLHMIADTVR 682
Score = 41.2 bits (95), Expect = 0.008
Identities = 53/260 (20%), Positives = 106/260 (40%), Gaps = 60/260 (23%)
Query: 139 MTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNS 198
+T +V+REL AV+ +A + EE + V + + V PD +A ++C
Sbjct: 93 LTSAVQRELAAVIAL----KARKSAIEQDEENNDKHVAVTEAESV--PDSQAGVMC---- 142
Query: 199 FGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHR 258
K R ++ + V ++ + L +K +K E + + V + +
Sbjct: 143 ------------KLQERDEIGRIELVQKLAKENYQFLQTDKKEQEKSEHQDDEVTTVQVK 190
Query: 259 ELDRT----------------GTRKGH---IVIKGTSERLTMHLVEEHSVVD------PT 293
E D++ G+ + H +V+ GT E++ HL+ + + + T
Sbjct: 191 EQDQSVLVLKKVQCCGPAPTAGSAESHWRYVVVSGTPEKILEHLLNDLHLEEVQDKETET 250
Query: 294 FIEDFLLTYRTFLSSPMEVGKKLLEWFND------------PSLRDKVTRVVLLWVNNHF 341
++DFLLTY F+++ ++ + LL ++ P + KV +V W+ +
Sbjct: 251 LLDDFLLTYTVFMTTD-DLCQALLRHYSAKKYQGKEENSDVPRRKRKVLHLVSQWIALYK 309
Query: 342 NDFEGDPAMTRFLEEFENNL 361
+ D FL+ N+
Sbjct: 310 DWLPEDEHSKMFLKTIYRNV 329
>gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform
b [Homo sapiens]
Length = 867
Score = 167 bits (423), Expect = 7e-41
Identities = 89/203 (43%), Positives = 127/203 (62%), Gaps = 3/203 (1%)
Query: 716 LSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRS-KTSCANLKRFEEVINQETFWVASE 774
+S+ ++A Q+++ ++ELF + E I F + K + ANL F N+ FWV +E
Sbjct: 627 MSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTE 686
Query: 775 ILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYE 834
I + KR++++K FIKIA HC+E KN NS FAI+ GL+ V+RL TWEKLP+K++
Sbjct: 687 ICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFK 746
Query: 835 KLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNF 894
K + + + L DPSRN YR L L+PP+IP P++ KD+TF HEGN + +D LVNF
Sbjct: 747 KFYAEFESLMDPSRNHRAYR--LTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNF 804
Query: 895 EKLRMIAKEIRHVGRMASVNMDP 917
EK+RMIA R V S +P
Sbjct: 805 EKMRMIANTARTVRYYRSQPFNP 827
Score = 107 bits (266), Expect = 1e-22
Identities = 81/307 (26%), Positives = 142/307 (46%), Gaps = 27/307 (8%)
Query: 78 LPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFA 137
LP E D++ +D + +R L K P RT DD+E + E + + A +
Sbjct: 155 LPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALS 214
Query: 138 NMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVT-YPDGKAEILCMG 196
+++ +V+REL V++F + GT++ N GEE SW +IL GSV V Y G L G
Sbjct: 215 HLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEG 274
Query: 197 NSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKE 256
+ FG ++ + + D+C F+ + ++D+ RIL VE N +++E + V+V E
Sbjct: 275 DDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLE 334
Query: 257 HRELDRTGTRKG-------HIVIKGTSERLTMHLVE----EHSVVDPT--FIEDFLLTYR 303
+ +G + V+ GT E++ H +E E ++ + T + DF++ +
Sbjct: 335 KVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHC 394
Query: 304 TFLSSPMEVGKKLLEWFNDPSL-------------RDKVTRVVLLWVNNHFNDFEGDPAM 350
F+ + + + PS + +V R+VL W + + + D
Sbjct: 395 VFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVS 454
Query: 351 TRFLEEF 357
FLEEF
Sbjct: 455 MAFLEEF 461
>gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform
a [Homo sapiens]
Length = 1011
Score = 167 bits (423), Expect = 7e-41
Identities = 89/203 (43%), Positives = 127/203 (62%), Gaps = 3/203 (1%)
Query: 716 LSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRS-KTSCANLKRFEEVINQETFWVASE 774
+S+ ++A Q+++ ++ELF + E I F + K + ANL F N+ FWV +E
Sbjct: 771 MSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTE 830
Query: 775 ILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYE 834
I + KR++++K FIKIA HC+E KN NS FAI+ GL+ V+RL TWEKLP+K++
Sbjct: 831 ICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFK 890
Query: 835 KLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNF 894
K + + + L DPSRN YR L L+PP+IP P++ KD+TF HEGN + +D LVNF
Sbjct: 891 KFYAEFESLMDPSRNHRAYR--LTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNF 948
Query: 895 EKLRMIAKEIRHVGRMASVNMDP 917
EK+RMIA R V S +P
Sbjct: 949 EKMRMIANTARTVRYYRSQPFNP 971
Score = 107 bits (266), Expect = 1e-22
Identities = 81/307 (26%), Positives = 142/307 (46%), Gaps = 27/307 (8%)
Query: 78 LPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFA 137
LP E D++ +D + +R L K P RT DD+E + E + + A +
Sbjct: 299 LPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALS 358
Query: 138 NMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVT-YPDGKAEILCMG 196
+++ +V+REL V++F + GT++ N GEE SW +IL GSV V Y G L G
Sbjct: 359 HLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEG 418
Query: 197 NSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKE 256
+ FG ++ + + D+C F+ + ++D+ RIL VE N +++E + V+V E
Sbjct: 419 DDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLE 478
Query: 257 HRELDRTGTRKG-------HIVIKGTSERLTMHLVE----EHSVVDPT--FIEDFLLTYR 303
+ +G + V+ GT E++ H +E E ++ + T + DF++ +
Sbjct: 479 KVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHC 538
Query: 304 TFLSSPMEVGKKLLEWFNDPSL-------------RDKVTRVVLLWVNNHFNDFEGDPAM 350
F+ + + + PS + +V R+VL W + + + D
Sbjct: 539 VFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVS 598
Query: 351 TRFLEEF 357
FLEEF
Sbjct: 599 MAFLEEF 605
Score = 40.8 bits (94), Expect = 0.010
Identities = 29/129 (22%), Positives = 64/129 (49%), Gaps = 10/129 (7%)
Query: 110 CLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEE 169
CL+K P++R+ +D++ + + ++ AF ++ ++C + +E+ G + G+
Sbjct: 18 CLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGYYENLEK-GITLFRQGDI 76
Query: 170 LDSWSVILNGSVEV----TYPDGKAEILC---MGNSFGVSPTMDKEYMKGVMRTKVDDCQ 222
+W +L GS++V T A +C +G +FG S +D + T+ + +
Sbjct: 77 GTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGES-ILDNTPRHATIVTR-ESSE 134
Query: 223 FVCIAQQDY 231
+ I Q+D+
Sbjct: 135 LLRIEQKDF 143
>gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1
[Homo sapiens]
Length = 456
Score = 159 bits (401), Expect = 3e-38
Identities = 82/194 (42%), Positives = 128/194 (65%), Gaps = 3/194 (1%)
Query: 720 EVATQLSMRNFELFRNIEPTEYIDDLFK-LRSKTSCANLKRFEEVINQETFWVASEILRE 778
+VA L+ ++ELFR + E++D +F R + ANL+ + ++ T WVA+E+L
Sbjct: 221 DVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLC 280
Query: 779 TNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQ 838
KR +++K FIKIA C++ ++ S +A++ GL+ A V+RLR TWEKLP K++ LF+
Sbjct: 281 EAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFR 340
Query: 839 DLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLR 898
++L DP RN YR V++ ++PP+IP P+I KDLTFLHEG+ + VDGLVN EKL
Sbjct: 341 KFENLTDPCRNHKSYREVIS--KMKPPVIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLH 398
Query: 899 MIAKEIRHVGRMAS 912
+A+++R + + S
Sbjct: 399 SVAEKVRTIRKYRS 412
>gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 155 bits (392), Expect = 3e-37
Identities = 103/295 (34%), Positives = 156/295 (52%), Gaps = 7/295 (2%)
Query: 634 VIQAIRE-FAVTATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNME 692
V ++RE A A D ++ +V V L +A + L+ R ++ N E
Sbjct: 536 VTASVREVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQE 595
Query: 693 TETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLF---KLR 749
L D S L +S ++A QL+ ++ LF +I E I + LR
Sbjct: 596 VHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLR 655
Query: 750 SKTSCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFA 809
T+ ANL+RF N+ +WVA+E+ R ++++ FIK+A H +E KN NS FA
Sbjct: 656 DVTT-ANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFA 714
Query: 810 IISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPL 869
++ GL+ + ++RL TWE+LP+K KL+ L+ L DPS N YR L L PP+IP
Sbjct: 715 VMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLAL--AKLSPPVIPF 772
Query: 870 FPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMASVNMDPALMFRTR 924
P++ KD+TF+HEGN + V+ L+NFEK+RM+A+ R + S N P R+R
Sbjct: 773 MPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSR 827
Score = 126 bits (317), Expect = 1e-28
Identities = 100/351 (28%), Positives = 169/351 (48%), Gaps = 43/351 (12%)
Query: 91 EEDIERASDPLMSRD---IVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRREL 147
EE++ A L R ++ L K P RTD++++ + E + + A A+++ SV+REL
Sbjct: 156 EEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKREL 215
Query: 148 CAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVE-VTYPDGKAEILCMGNSFGVSPTMD 206
AV++F +AGT++ + G++ SW +I GSV VT+ G L G+ FG ++
Sbjct: 216 AAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVN 275
Query: 207 KEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDR---- 262
+ + D+C F+ + +QD+ RI+ VE ++EE G++V+V E
Sbjct: 276 DAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSR 335
Query: 263 --TGTRKGHIVIKGTSERLTMHLVE----EHSVVDP--TFIEDFLLTYRTFLSSPMEVGK 314
T R + V+ GT E++ L+E + S DP TF+ DFLLT+R F+ S
Sbjct: 336 PPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAA 395
Query: 315 KLLEWFNDP-------------SLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFE--- 358
L + +P + R ++ R+V WV + + DP T FL++
Sbjct: 396 LLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLV 455
Query: 359 ------NNLEREKMGGHLRL--LNIAC---AAKAKRRLMTLTKPSREAPLP 398
+NL RE+ R L C + + K R + + P+++ PLP
Sbjct: 456 GRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWLPNQDEPLP 506
>gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 155 bits (392), Expect = 3e-37
Identities = 103/295 (34%), Positives = 156/295 (52%), Gaps = 7/295 (2%)
Query: 634 VIQAIRE-FAVTATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNME 692
V ++RE A A D ++ +V V L +A + L+ R ++ N E
Sbjct: 536 VTASVREVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQE 595
Query: 693 TETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLF---KLR 749
L D S L +S ++A QL+ ++ LF +I E I + LR
Sbjct: 596 VHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLR 655
Query: 750 SKTSCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFA 809
T+ ANL+RF N+ +WVA+E+ R ++++ FIK+A H +E KN NS FA
Sbjct: 656 DVTT-ANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFA 714
Query: 810 IISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPL 869
++ GL+ + ++RL TWE+LP+K KL+ L+ L DPS N YR L L PP+IP
Sbjct: 715 VMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLAL--AKLSPPVIPF 772
Query: 870 FPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMASVNMDPALMFRTR 924
P++ KD+TF+HEGN + V+ L+NFEK+RM+A+ R + S N P R+R
Sbjct: 773 MPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSR 827
Score = 126 bits (317), Expect = 1e-28
Identities = 100/351 (28%), Positives = 169/351 (48%), Gaps = 43/351 (12%)
Query: 91 EEDIERASDPLMSRD---IVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRREL 147
EE++ A L R ++ L K P RTD++++ + E + + A A+++ SV+REL
Sbjct: 156 EEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKREL 215
Query: 148 CAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVE-VTYPDGKAEILCMGNSFGVSPTMD 206
AV++F +AGT++ + G++ SW +I GSV VT+ G L G+ FG ++
Sbjct: 216 AAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVN 275
Query: 207 KEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDR---- 262
+ + D+C F+ + +QD+ RI+ VE ++EE G++V+V E
Sbjct: 276 DAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSR 335
Query: 263 --TGTRKGHIVIKGTSERLTMHLVE----EHSVVDP--TFIEDFLLTYRTFLSSPMEVGK 314
T R + V+ GT E++ L+E + S DP TF+ DFLLT+R F+ S
Sbjct: 336 PPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAA 395
Query: 315 KLLEWFNDP-------------SLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFE--- 358
L + +P + R ++ R+V WV + + DP T FL++
Sbjct: 396 LLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLV 455
Query: 359 ------NNLEREKMGGHLRL--LNIAC---AAKAKRRLMTLTKPSREAPLP 398
+NL RE+ R L C + + K R + + P+++ PLP
Sbjct: 456 GRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWLPNQDEPLP 506
>gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a
[Homo sapiens]
Length = 923
Score = 155 bits (392), Expect = 3e-37
Identities = 103/295 (34%), Positives = 156/295 (52%), Gaps = 7/295 (2%)
Query: 634 VIQAIRE-FAVTATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNME 692
V ++RE A A D ++ +V V L +A + L+ R ++ N E
Sbjct: 578 VTASVREVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQE 637
Query: 693 TETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLF---KLR 749
L D S L +S ++A QL+ ++ LF +I E I + LR
Sbjct: 638 VHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLR 697
Query: 750 SKTSCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFA 809
T+ ANL+RF N+ +WVA+E+ R ++++ FIK+A H +E KN NS FA
Sbjct: 698 DVTT-ANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFA 756
Query: 810 IISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPL 869
++ GL+ + ++RL TWE+LP+K KL+ L+ L DPS N YR L L PP+IP
Sbjct: 757 VMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLAL--AKLSPPVIPF 814
Query: 870 FPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMASVNMDPALMFRTR 924
P++ KD+TF+HEGN + V+ L+NFEK+RM+A+ R + S N P R+R
Sbjct: 815 MPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSR 869
Score = 126 bits (317), Expect = 1e-28
Identities = 100/351 (28%), Positives = 169/351 (48%), Gaps = 43/351 (12%)
Query: 91 EEDIERASDPLMSRD---IVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRREL 147
EE++ A L R ++ L K P RTD++++ + E + + A A+++ SV+REL
Sbjct: 198 EEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKREL 257
Query: 148 CAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVE-VTYPDGKAEILCMGNSFGVSPTMD 206
AV++F +AGT++ + G++ SW +I GSV VT+ G L G+ FG ++
Sbjct: 258 AAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVN 317
Query: 207 KEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDR---- 262
+ + D+C F+ + +QD+ RI+ VE ++EE G++V+V E
Sbjct: 318 DAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSR 377
Query: 263 --TGTRKGHIVIKGTSERLTMHLVE----EHSVVDP--TFIEDFLLTYRTFLSSPMEVGK 314
T R + V+ GT E++ L+E + S DP TF+ DFLLT+R F+ S
Sbjct: 378 PPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAA 437
Query: 315 KLLEWFNDP-------------SLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFE--- 358
L + +P + R ++ R+V WV + + DP T FL++
Sbjct: 438 LLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLV 497
Query: 359 ------NNLEREKMGGHLRL--LNIAC---AAKAKRRLMTLTKPSREAPLP 398
+NL RE+ R L C + + K R + + P+++ PLP
Sbjct: 498 GRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWLPNQDEPLP 548
>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
sapiens]
Length = 1095
Score = 102 bits (255), Expect = 2e-21
Identities = 65/177 (36%), Positives = 97/177 (54%), Gaps = 8/177 (4%)
Query: 720 EVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRET 779
E+A QL++ + ELF IE E + K +++ NL +F E N ++WV S I+ +
Sbjct: 861 EIAEQLTLLDAELFYKIEIPEVLL-WAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQE 919
Query: 780 NQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQD 839
R +++ FIKI H R+ NFNS AI+S L+ AP+ RL W+K + + +
Sbjct: 920 KAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE--WQK---QTSEGLAE 974
Query: 840 LQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEK 896
L D S + YR L+ ++PP IP +I +DLTF+H GN +DG VNF K
Sbjct: 975 YCTLIDSSSSFRAYRAALS--EVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSK 1029
Score = 32.7 bits (73), Expect = 2.7
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 6/76 (7%)
Query: 246 EEEGEIVMVKEHRELDRTGTRK-----GHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL 300
EEE + + + +H E+ T K G V G+ + L +H E + E FL
Sbjct: 680 EEEVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLT 739
Query: 301 TYRTFLSSPMEVGKKL 316
TYRTF+ SP E+ KKL
Sbjct: 740 TYRTFI-SPEELIKKL 754
>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
sapiens]
Length = 1077
Score = 102 bits (255), Expect = 2e-21
Identities = 65/177 (36%), Positives = 97/177 (54%), Gaps = 8/177 (4%)
Query: 720 EVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRET 779
E+A QL++ + ELF IE E + K +++ NL +F E N ++WV S I+ +
Sbjct: 843 EIAEQLTLLDAELFYKIEIPEVLL-WAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQE 901
Query: 780 NQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQD 839
R +++ FIKI H R+ NFNS AI+S L+ AP+ RL W+K + + +
Sbjct: 902 KAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE--WQK---QTSEGLAE 956
Query: 840 LQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEK 896
L D S + YR L+ ++PP IP +I +DLTF+H GN +DG VNF K
Sbjct: 957 YCTLIDSSSSFRAYRAALS--EVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSK 1011
Score = 32.7 bits (73), Expect = 2.7
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 6/76 (7%)
Query: 246 EEEGEIVMVKEHRELDRTGTRK-----GHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL 300
EEE + + + +H E+ T K G V G+ + L +H E + E FL
Sbjct: 662 EEEVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLT 721
Query: 301 TYRTFLSSPMEVGKKL 316
TYRTF+ SP E+ KKL
Sbjct: 722 TYRTFI-SPEELIKKL 736
>gi|22749129 RasGEF domain family, member 1B [Homo sapiens]
Length = 473
Score = 101 bits (252), Expect = 5e-21
Identities = 67/204 (32%), Positives = 107/204 (52%), Gaps = 23/204 (11%)
Query: 721 VATQLSMRNFELFRNIEPTEYIDDLFK---LRSKTSC-------ANLKRFEEVINQETFW 770
+A QL+ E I P E++ + L + SC NL+ + E N+ ++
Sbjct: 209 LAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYL 268
Query: 771 VASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLP 830
VA+EI + R ++I++FI +A C NFNS+ AIISG+N++PV+RL+ TW K+
Sbjct: 269 VATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVK 328
Query: 831 NKYEKLFQDLQDLFDPSRNMAKYRNVLNS---------QNLQPPIIPLFPVIKKDLTFLH 881
F L+ DPS N YR L + + +IP F ++ KD+ FL+
Sbjct: 329 T---AKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLN 385
Query: 882 EGNDSKV-DGLVNFEKLRMIAKEI 904
EG +++ +G VNFEK +AK++
Sbjct: 386 EGCANRLPNGHVNFEKFWELAKQV 409
>gi|40255197 RasGEF domain family, member 1C [Homo sapiens]
Length = 466
Score = 101 bits (252), Expect = 5e-21
Identities = 67/202 (33%), Positives = 109/202 (53%), Gaps = 21/202 (10%)
Query: 721 VATQLSMRNFELFRNIEPTEYIDDLFK---LRSKTSC-----ANLKRFEEVINQETFWVA 772
+A QL+ E R+I P E++ L S C +NL+ + + N+ + VA
Sbjct: 204 LAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTSNLEAYVKWFNRLCYLVA 263
Query: 773 SEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNK 832
+EI + +R ++I+ FI +A C NFNS+ AIISG+N++PV+RL+ TW K+ +
Sbjct: 264 TEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKV--R 321
Query: 833 YEKLFQDLQDLFDPSRNMAKYRNVLNS---------QNLQPPIIPLFPVIKKDLTFLHEG 883
K F L+ DP+ N YR L + + +IP F ++ KD+ FL+EG
Sbjct: 322 TAKFF-ILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREKIVIPFFSLLIKDIYFLNEG 380
Query: 884 NDSKV-DGLVNFEKLRMIAKEI 904
+++ +G VNFEK +AK++
Sbjct: 381 CANRLPNGHVNFEKFLELAKQV 402
>gi|117168263 RasGEF domain family, member 1A [Homo sapiens]
Length = 481
Score = 95.9 bits (237), Expect = 3e-19
Identities = 63/224 (28%), Positives = 116/224 (51%), Gaps = 13/224 (5%)
Query: 691 METETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRS 750
++T+ + +D + + + QL+ +E+ S+ +L + + + +D+
Sbjct: 197 LKTKPPAAQKDILGVCCDPLVLAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCRGD 256
Query: 751 KTSCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAI 810
T +L+ ++ N + VA+E+ R + R ++++ FI +A C NFNSM AI
Sbjct: 257 LTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAI 316
Query: 811 ISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLN---------SQN 861
ISG+NL+PVARL+ TW K+ F L+ DPS N YR L + +
Sbjct: 317 ISGMNLSPVARLKKTWSKVKT---AKFDVLEHHMDPSSNFCNYRTALQGATQRSQMANSS 373
Query: 862 LQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEI 904
+ +IP+F + KD+ FLH+ + + + +G +NF+K I+++I
Sbjct: 374 REKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQI 417
>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 3 [Homo sapiens]
Length = 1257
Score = 91.7 bits (226), Expect = 5e-18
Identities = 58/193 (30%), Positives = 96/193 (49%), Gaps = 4/193 (2%)
Query: 717 STVEVATQLSMRNFELFRNIEPTEYIDD-LFKLRSKTSCANLKRFEEVINQETFWVASEI 775
S +E+A QL++ + +F+ I E+ KL + + + N + +ASEI
Sbjct: 1022 SALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEI 1081
Query: 776 LRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEK 835
+R + R+ I+ ++ +A CR N+N++ I S +N + + RL+ TW K+ + +
Sbjct: 1082 IRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKA 1141
Query: 836 LFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNF 894
L LQ L R L +N PP +P + DL F+ EG + DGLVNF
Sbjct: 1142 LIDKLQKLVSSEGRFKNLREAL--KNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNF 1199
Query: 895 EKLRMIAKEIRHV 907
K+RMI+ IR +
Sbjct: 1200 SKMRMISHIIREI 1212
>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 1 [Homo sapiens]
Length = 1273
Score = 91.7 bits (226), Expect = 5e-18
Identities = 58/193 (30%), Positives = 96/193 (49%), Gaps = 4/193 (2%)
Query: 717 STVEVATQLSMRNFELFRNIEPTEYIDD-LFKLRSKTSCANLKRFEEVINQETFWVASEI 775
S +E+A QL++ + +F+ I E+ KL + + + N + +ASEI
Sbjct: 1038 SALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEI 1097
Query: 776 LRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEK 835
+R + R+ I+ ++ +A CR N+N++ I S +N + + RL+ TW K+ + +
Sbjct: 1098 IRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKA 1157
Query: 836 LFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNF 894
L LQ L R L +N PP +P + DL F+ EG + DGLVNF
Sbjct: 1158 LIDKLQKLVSSEGRFKNLREAL--KNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNF 1215
Query: 895 EKLRMIAKEIRHV 907
K+RMI+ IR +
Sbjct: 1216 SKMRMISHIIREI 1228
>gi|24797101 Ras protein-specific guanine nucleotide-releasing
factor 1 isoform 2 [Homo sapiens]
Length = 489
Score = 91.7 bits (226), Expect = 5e-18
Identities = 58/193 (30%), Positives = 96/193 (49%), Gaps = 4/193 (2%)
Query: 717 STVEVATQLSMRNFELFRNIEPTEYIDD-LFKLRSKTSCANLKRFEEVINQETFWVASEI 775
S +E+A QL++ + +F+ I E+ KL + + + N + +ASEI
Sbjct: 254 SALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEI 313
Query: 776 LRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEK 835
+R + R+ I+ ++ +A CR N+N++ I S +N + + RL+ TW K+ + +
Sbjct: 314 IRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKA 373
Query: 836 LFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNF 894
L LQ L R L +N PP +P + DL F+ EG + DGLVNF
Sbjct: 374 LIDKLQKLVSSEGRFKNLREAL--KNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNF 431
Query: 895 EKLRMIAKEIRHV 907
K+RMI+ IR +
Sbjct: 432 SKMRMISHIIREI 444
>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
sapiens]
Length = 583
Score = 90.5 bits (223), Expect = 1e-17
Identities = 79/344 (22%), Positives = 148/344 (43%), Gaps = 54/344 (15%)
Query: 713 LLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCA-NLKRFEEVINQETFWV 771
+L+++ E A Q+++ + +F+ I+P E + + K S A N F N +FWV
Sbjct: 45 VLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWV 104
Query: 772 ASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPN 831
EIL R +++ H+IK A E N +++ A++SGL AP+ RL TW L
Sbjct: 105 VREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSR 164
Query: 832 KYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGL 891
K + F+ L+ + N + R+ ++S + P IP + DLT++ S L
Sbjct: 165 KDKTTFEKLEYVMSKEDNYKRLRDYISSLKM-TPCIPYLGIYLSDLTYIDSAYPSTGSIL 223
Query: 892 VNFEKLRMIAKEIRHVGRM-ASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTG 950
N ++ ++ +R + + S D ++ +K
Sbjct: 224 ENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQK------------------------- 258
Query: 951 GHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKN 1010
+LN+ QY+ L+ +++++ + LSL+ EP T+T P++
Sbjct: 259 ----------YLNS-------------VQYIEELQKFVEDDNYK-LSLKIEPGTST-PRS 293
Query: 1011 PGDKKPVKSETSPVAPRAGSQQ-KAQSLPQPQQQPPPAHKINQG 1053
++ + +P++G + A+ PQ P P + I G
Sbjct: 294 AASREDLVGPEVGASPQSGRKSVAAEGALLPQTPPSPRNLIPHG 337
>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
2 [Homo sapiens]
Length = 1237
Score = 89.7 bits (221), Expect = 2e-17
Identities = 57/194 (29%), Positives = 95/194 (48%), Gaps = 4/194 (2%)
Query: 716 LSTVEVATQLSMRNFELFRNIEPTEYIDD-LFKLRSKTSCANLKRFEEVINQETFWVASE 774
LS +E+A Q+++ + +FR+I E++ KL + + + N + VAS+
Sbjct: 1001 LSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQ 1060
Query: 775 ILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYE 834
I+ + R I+ ++ +A CR N+N + I S LN + + RL+ TW K+ + +
Sbjct: 1061 IMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTK 1120
Query: 835 KLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDS-KVDGLVN 893
L LQ R L +N PP +P + DL F+ EG + +GLVN
Sbjct: 1121 ALMDKLQKTVSSEGRFKNLRETL--KNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVN 1178
Query: 894 FEKLRMIAKEIRHV 907
F K+RMI+ IR +
Sbjct: 1179 FSKMRMISHIIREI 1192
>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
Length = 1333
Score = 88.2 bits (217), Expect = 5e-17
Identities = 54/195 (27%), Positives = 100/195 (51%), Gaps = 9/195 (4%)
Query: 713 LLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKT-SCANLKRFEEVINQETFWV 771
LL L +E+A QL++ +L+R ++P+E + ++ K + NL + T W
Sbjct: 776 LLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWF 835
Query: 772 ASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPN 831
I+ N +R+ ++ I+I +E NFN + ++S +N +PV RL T+E++P+
Sbjct: 836 EKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPS 895
Query: 832 KYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV--- 888
+ +K+ ++ +L + + KY L S N PP +P F + ++ EGN +
Sbjct: 896 RQKKILEEAHELSED--HYKKYLAKLRSIN--PPCVPFFGIYLTNILKTEEGNPEVLKRH 951
Query: 889 -DGLVNFEKLRMIAK 902
L+NF K R +A+
Sbjct: 952 GKELINFSKRRKVAE 966
Score = 42.0 bits (97), Expect = 0.004
Identities = 33/122 (27%), Positives = 48/122 (39%), Gaps = 38/122 (31%)
Query: 277 ERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPS------------ 324
ERLT H+ DP F+ FL TYR+F P E+ ++E F P
Sbjct: 611 ERLTYHMY-----ADPNFVRTFLTTYRSF-CKPQELLSLIIERFEIPEPEPTEADRIAIE 664
Query: 325 --------------------LRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLERE 364
++ +V V WV +HF DFE D + + +EEF + +
Sbjct: 665 NGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGK 724
Query: 365 KM 366
M
Sbjct: 725 AM 726
>gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo
sapiens]
Length = 557
Score = 85.9 bits (211), Expect = 3e-16
Identities = 52/169 (30%), Positives = 85/169 (50%), Gaps = 2/169 (1%)
Query: 713 LLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCA-NLKRFEEVINQETFWV 771
+L+++ E A+Q+++ + +F+ I+P E + + K S A N+ F NQ +FWV
Sbjct: 46 VLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWV 105
Query: 772 ASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPN 831
EIL R +I+ HF+KIA E N +S+ +++S L AP+ RL TW L
Sbjct: 106 VREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNR 165
Query: 832 KYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFL 880
K + F+ L L N + R + S + P IP + DL ++
Sbjct: 166 KDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPS-IPYLGIYLLDLIYI 213
>gi|154689780 son of sevenless homolog 2 [Homo sapiens]
Length = 1332
Score = 78.6 bits (192), Expect = 4e-14
Identities = 50/195 (25%), Positives = 95/195 (48%), Gaps = 9/195 (4%)
Query: 713 LLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKT-SCANLKRFEEVINQETFWV 771
L+ L +E+A QL++ +L+R ++P+E + ++ K + NL + T W
Sbjct: 774 LMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWF 833
Query: 772 ASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPN 831
I+ N +R+ ++ I+I ++ NFN + I+S +N V RL T+E L
Sbjct: 834 EKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQE 893
Query: 832 KYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGND----SK 887
+ K+ + +L + KY ++ +++ PP +P F + ++ EGN+ K
Sbjct: 894 RKRKILDEAVEL--SQDHFKKY--LVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKK 949
Query: 888 VDGLVNFEKLRMIAK 902
L+NF K R +A+
Sbjct: 950 GKDLINFSKRRKVAE 964
Score = 45.4 bits (106), Expect = 4e-04
Identities = 37/138 (26%), Positives = 55/138 (39%), Gaps = 33/138 (23%)
Query: 261 DRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWF 320
D +R G +IKG + + + H DP F+ FL TYR+F P E+ L+E F
Sbjct: 588 DNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCK-PQELLSLLIERF 646
Query: 321 N----DPSLRDK----------------------------VTRVVLLWVNNHFNDFEGDP 348
+P+ DK + V WV +HF DFE D
Sbjct: 647 EIPEPEPTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDL 706
Query: 349 AMTRFLEEFENNLEREKM 366
+ LE F +++ + M
Sbjct: 707 ELLERLESFISSVRGKAM 724
>gi|93102367 ral guanine nucleotide dissociation stimulator-like 1
[Homo sapiens]
Length = 803
Score = 73.9 bits (180), Expect = 1e-12
Identities = 112/458 (24%), Positives = 177/458 (38%), Gaps = 68/458 (14%)
Query: 689 NNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKL 748
N + S E+ +EL S VA QL+ + +LF+ + P + ++
Sbjct: 239 NGLPNTISFSLEEEEELEGGESAEFTCFSEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSR 298
Query: 749 RSKTSCANL----KRFEEVINQETFWVASEIL--RETNQLKRMKIIKHFIKIALHCRECK 802
R K +L + N T V S IL +E +R KII+ +I IA CR K
Sbjct: 299 RDKKENKHLAPTIRATISQFNTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLK 358
Query: 803 NFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNL 862
NF+S+ AI+S L + RL+ TW +P +F++L D+F N R +L
Sbjct: 359 NFSSLRAIVSALQSNSIYRLKKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMK--- 415
Query: 863 QPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKE-IRHVGRMASVNMDPALMF 921
+G F L KE + R + D +M
Sbjct: 416 --------------------------EGTSKFANLDSSVKENQKRTQRRLQLQKDMGVMQ 449
Query: 922 RTRKKKWRSLGSLSQGSTNATVLDVAQ----TGG---HKKRVRRSSFLNAKKLYEDAQMA 974
T + L T+ T+LD A GG +KR R + KL + A +
Sbjct: 450 GT-------VPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQSACNS 502
Query: 975 ------RKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKNPGDKKPVKSETSPVAPRA 1028
+K Q+ +L +EES LS + E A + +P KP KS ++
Sbjct: 503 YCMTPDQKFIQWFQRQQLLTEEES-YALSCEIEAAADASTTSP---KPRKSMVKRLSLLF 558
Query: 1029 GSQQKAQSLPQPQQQPPPAHKINQGLQVPAVSL---YPSRKKVPVKDLPPFGINSPQALK 1085
S ++QP + G + +VS+ + + + P +++P +
Sbjct: 559 LGSDMITSPTPTKEQPKSTASGSSGESMDSVSVSSCESNHSEAEEGSITP--MDTPDEPQ 616
Query: 1086 KILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQS 1123
K LS S H + DT S+ S L +P +SP S
Sbjct: 617 KKLSESSSSCSSIH---SMDTNSSGMSSLINPLSSPPS 651
>gi|24307909 ral guanine nucleotide dissociation stimulator isoform
1 [Homo sapiens]
Length = 914
Score = 73.6 bits (179), Expect = 1e-12
Identities = 49/166 (29%), Positives = 82/166 (49%), Gaps = 14/166 (8%)
Query: 702 AQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSK--------TS 753
A+ L E + LL VA Q ++ + ELF+ + P + ++ R K T
Sbjct: 371 AENGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTI 430
Query: 754 CANLKRFEEVINQETFWVASEIL--RETNQLKRMKIIKHFIKIALHCRECKNFNSMFAII 811
A + +F V N V + L R T R ++++H+I++A CR KNF+S++AI+
Sbjct: 431 RATVTQFNSVAN----CVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAIL 486
Query: 812 SGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVL 857
S L + RL+ TWE + ++FQ L ++F N + R +L
Sbjct: 487 SALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELL 532
>gi|108796058 ral guanine nucleotide dissociation stimulator isoform
2 [Homo sapiens]
Length = 859
Score = 73.6 bits (179), Expect = 1e-12
Identities = 49/166 (29%), Positives = 82/166 (49%), Gaps = 14/166 (8%)
Query: 702 AQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSK--------TS 753
A+ L E + LL VA Q ++ + ELF+ + P + ++ R K T
Sbjct: 316 AENGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTI 375
Query: 754 CANLKRFEEVINQETFWVASEIL--RETNQLKRMKIIKHFIKIALHCRECKNFNSMFAII 811
A + +F V N V + L R T R ++++H+I++A CR KNF+S++AI+
Sbjct: 376 RATVTQFNSVAN----CVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAIL 431
Query: 812 SGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVL 857
S L + RL+ TWE + ++FQ L ++F N + R +L
Sbjct: 432 SALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELL 477
>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
sapiens]
Length = 762
Score = 73.2 bits (178), Expect = 2e-12
Identities = 62/211 (29%), Positives = 104/211 (49%), Gaps = 8/211 (3%)
Query: 707 RESQISLL--QLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVI 764
++ ++SLL L E++ L+ F+ FR I ++Y + L K + ++R +
Sbjct: 193 KKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKEN-PTMERSIALC 251
Query: 765 NQETFWVASEIL-RETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLR 823
N + WV +L R T QL+ IK FI++A + +NFN++ A+I GL + ++RL+
Sbjct: 252 NGISQWVQLMVLSRPTPQLRAEVFIK-FIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLK 310
Query: 824 TTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEG 883
T +P++ K+ ++ +L SRN YR IP+ V KDL L+E
Sbjct: 311 ETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYG--ECTDFKIPILGVHLKDLISLYEA 368
Query: 884 -NDSKVDGLVNFEKLRMIAKEIRHVGRMASV 913
D DG VN KL + I + ++ V
Sbjct: 369 MPDYLEDGKVNVHKLLALYNHISELVQLQEV 399
Score = 32.3 bits (72), Expect = 3.5
Identities = 26/113 (23%), Positives = 51/113 (45%), Gaps = 12/113 (10%)
Query: 299 LLTYRTFLSSPMEVGKKLLEWFND------PSLRDKVTRVVLLWVNNHFNDFEGDPAMTR 352
+LT + S E+ +K++ + D P L K+ V W+ + F+ D ++T
Sbjct: 89 MLTMHRIVISSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTD 148
Query: 353 FLEEFENNLEREKMGGHLRLLNIA------CAAKAKRRLMTLTKPSREAPLPF 399
+EEF+ ++ + H RL++ + K +R+ + T R+ L F
Sbjct: 149 TMEEFQELVKAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLF 201
>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
sapiens]
Length = 797
Score = 73.2 bits (178), Expect = 2e-12
Identities = 62/211 (29%), Positives = 104/211 (49%), Gaps = 8/211 (3%)
Query: 707 RESQISLL--QLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVI 764
++ ++SLL L E++ L+ F+ FR I ++Y + L K + ++R +
Sbjct: 193 KKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKEN-PTMERSIALC 251
Query: 765 NQETFWVASEIL-RETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLR 823
N + WV +L R T QL+ IK FI++A + +NFN++ A+I GL + ++RL+
Sbjct: 252 NGISQWVQLMVLSRPTPQLRAEVFIK-FIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLK 310
Query: 824 TTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEG 883
T +P++ K+ ++ +L SRN YR IP+ V KDL L+E
Sbjct: 311 ETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYG--ECTDFKIPILGVHLKDLISLYEA 368
Query: 884 -NDSKVDGLVNFEKLRMIAKEIRHVGRMASV 913
D DG VN KL + I + ++ V
Sbjct: 369 MPDYLEDGKVNVHKLLALYNHISELVQLQEV 399
Score = 32.3 bits (72), Expect = 3.5
Identities = 26/113 (23%), Positives = 51/113 (45%), Gaps = 12/113 (10%)
Query: 299 LLTYRTFLSSPMEVGKKLLEWFND------PSLRDKVTRVVLLWVNNHFNDFEGDPAMTR 352
+LT + S E+ +K++ + D P L K+ V W+ + F+ D ++T
Sbjct: 89 MLTMHRIVISSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTD 148
Query: 353 FLEEFENNLEREKMGGHLRLLNIA------CAAKAKRRLMTLTKPSREAPLPF 399
+EEF+ ++ + H RL++ + K +R+ + T R+ L F
Sbjct: 149 TMEEFQELVKAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLF 201
>gi|13376349 PDZ domain containing 7 [Homo sapiens]
Length = 517
Score = 72.8 bits (177), Expect = 2e-12
Identities = 36/82 (43%), Positives = 52/82 (63%)
Query: 383 RRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFE 442
RR++ L S + L F + GG E G GI+V VD G A E G+K GDQ+L NG F+
Sbjct: 208 RRIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQVLAANGVRFD 267
Query: 443 NIQLSKAMEILRNNTHLSITVK 464
+I S+A+E+L+ TH+ +T+K
Sbjct: 268 DISHSQAVEVLKGQTHIMLTIK 289
Score = 60.1 bits (144), Expect = 2e-08
Identities = 30/68 (44%), Positives = 44/68 (64%)
Query: 397 LPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNN 456
L F + GGSE G GIFV V+ GS A AGL GD+I EVNG + E+ + A+++L ++
Sbjct: 97 LGFSVRGGSEHGLGIFVSKVEEGSSAERAGLCVGDKITEVNGLSLESTTMGSAVKVLTSS 156
Query: 457 THLSITVK 464
+ L + V+
Sbjct: 157 SRLHMMVR 164
>gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo
sapiens]
Length = 659
Score = 69.7 bits (169), Expect = 2e-11
Identities = 60/238 (25%), Positives = 106/238 (44%), Gaps = 10/238 (4%)
Query: 667 RLPDQLSKLADRIQLSGRYYL----KNNMETETLCSDEDAQELLRESQISLL--QLSTVE 720
R P+ + + ++ GR++ + N L D L ++ ++SLL L T E
Sbjct: 131 RHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLPGLGKKRKVSLLFDHLETGE 190
Query: 721 VATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETN 780
+A L+ F F+ I P + + + S C L+ + N + WV +L
Sbjct: 191 LAQHLTYLEFRSFQAITPQDLRSYVLQ-GSVRGCPALEGSVGLSNSVSRWVQVMVLSRPG 249
Query: 781 QLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDL 840
L+R +++ FI +A + +NFN++ A+ GL + ++RL+ + L K +L
Sbjct: 250 PLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLEL 309
Query: 841 QDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKL 897
+L N A+YR +P+ V KDL LHE ++ DG ++ KL
Sbjct: 310 TELLASHNNYARYRRTW--AGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKL 365
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.370
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,777,051
Number of Sequences: 37866
Number of extensions: 2862829
Number of successful extensions: 12870
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 156
Number of HSP's successfully gapped in prelim test: 278
Number of HSP's that attempted gapping in prelim test: 11520
Number of HSP's gapped (non-prelim): 1501
length of query: 1499
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1384
effective length of database: 13,892,928
effective search space: 19227812352
effective search space used: 19227812352
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.