Search of human proteins with 75677331

Search of human proteins with 75677331

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|75677331 WD repeat domain, phosphoinositide interacting 2
isoform d [Homo sapiens]
         (425 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|75677331 WD repeat domain, phosphoinositide interacting 2 iso...   851   0.0  
gi|54111428 WD repeat domain, phosphoinositide interacting 2 iso...   842   0.0  
gi|75677329 WD repeat domain, phosphoinositide interacting 2 iso...   840   0.0  
gi|7661580 WD repeat domain, phosphoinositide interacting 2 isof...   831   0.0  
gi|75677340 WD repeat domain, phosphoinositide interacting 2 iso...   748   0.0  
gi|157388939 WD repeat domain, phosphoinositide interacting 1 [H...   480   e-135
gi|122939167 WDR45-like [Homo sapiens]                                140   2e-33
gi|71483646 WD repeat domain 45 isoform 2 [Homo sapiens]              101   1e-21
gi|47059042 WD repeat domain 45 isoform 1 [Homo sapiens]              100   3e-21
gi|21071067 TBP-associated factor 5 [Homo sapiens]                     50   4e-06
gi|186928847 cirhin [Homo sapiens]                                     42   0.001
gi|32189425 WD repeat domain 69 [Homo sapiens]                         40   0.004
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             38   0.015
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             38   0.020
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             38   0.020
gi|153218631 breast carcinoma amplified sequence 3 isoform 1 [Ho...    37   0.026
gi|153218595 breast carcinoma amplified sequence 3 isoform 2 [Ho...    37   0.026
gi|26665869 WD repeat domain 51B [Homo sapiens]                        35   0.13 
gi|5901892 WD repeat and HMG-box DNA binding protein 1 isoform 1...    34   0.22 
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom...    34   0.22 
gi|14150171 THO complex 3 [Homo sapiens]                               34   0.22 
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ...    33   0.49 
gi|13376840 WD repeat domain 61 [Homo sapiens]                         33   0.64 
gi|148528998 Dmx-like 1 [Homo sapiens]                                 33   0.64 
gi|157739942 gemin 5 [Homo sapiens]                                    32   0.84 
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [...    32   0.84 
gi|38569484 kinesin family member 21A [Homo sapiens]                   32   1.4  
gi|56550086 WD repeat and HMG-box DNA binding protein 1 isoform ...    32   1.4  
gi|94400919 WD repeat domain 90 [Homo sapiens]                         32   1.4  
gi|21541824 transducin-like enhancer protein 1 [Homo sapiens]          31   1.9  

>gi|75677331 WD repeat domain, phosphoinositide interacting 2
           isoform d [Homo sapiens]
          Length = 425

 Score =  851 bits (2198), Expect = 0.0
 Identities = 425/425 (100%), Positives = 425/425 (100%)

Query: 1   MNLASQSGEAGAGQLLFANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCI 60
           MNLASQSGEAGAGQLLFANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCI
Sbjct: 1   MNLASQSGEAGAGQLLFANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCI 60

Query: 61  VERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLY 120
           VERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLY
Sbjct: 61  VERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLY 120

Query: 121 IHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMI 180
           IHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMI
Sbjct: 121 IHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMI 180

Query: 181 PAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSM 240
           PAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSM
Sbjct: 181 PAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSM 240

Query: 241 DGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVTEMFNQGR 300
           DGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVTEMFNQGR
Sbjct: 241 DGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVTEMFNQGR 300

Query: 301 AFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMKQHRLDGS 360
           AFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMKQHRLDGS
Sbjct: 301 AFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMKQHRLDGS 360

Query: 361 LETTNEILDSASHDCPLVTQTYGAAAGKAYTDDLGAVGGACLEDEASALRLDEDSEHPPM 420
           LETTNEILDSASHDCPLVTQTYGAAAGKAYTDDLGAVGGACLEDEASALRLDEDSEHPPM
Sbjct: 361 LETTNEILDSASHDCPLVTQTYGAAAGKAYTDDLGAVGGACLEDEASALRLDEDSEHPPM 420

Query: 421 ILRTD 425
           ILRTD
Sbjct: 421 ILRTD 425


>gi|54111428 WD repeat domain, phosphoinositide interacting 2
           isoform b [Homo sapiens]
          Length = 436

 Score =  842 bits (2176), Expect = 0.0
 Identities = 425/436 (97%), Positives = 425/436 (97%), Gaps = 11/436 (2%)

Query: 1   MNLASQSGEAGAGQLLFANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCI 60
           MNLASQSGEAGAGQLLFANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCI
Sbjct: 1   MNLASQSGEAGAGQLLFANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCI 60

Query: 61  VERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLY 120
           VERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLY
Sbjct: 61  VERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLY 120

Query: 121 IHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMI 180
           IHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMI
Sbjct: 121 IHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMI 180

Query: 181 PAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSM 240
           PAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSM
Sbjct: 181 PAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSM 240

Query: 241 DGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVTEMFNQGR 300
           DGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVTEMFNQGR
Sbjct: 241 DGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVTEMFNQGR 300

Query: 301 AFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMKQHRLDGS 360
           AFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMKQHRLDGS
Sbjct: 301 AFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMKQHRLDGS 360

Query: 361 LETTNEILDSASHDCPLVTQTYGAAAGK-----------AYTDDLGAVGGACLEDEASAL 409
           LETTNEILDSASHDCPLVTQTYGAAAGK           AYTDDLGAVGGACLEDEASAL
Sbjct: 361 LETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYTDDLGAVGGACLEDEASAL 420

Query: 410 RLDEDSEHPPMILRTD 425
           RLDEDSEHPPMILRTD
Sbjct: 421 RLDEDSEHPPMILRTD 436


>gi|75677329 WD repeat domain, phosphoinositide interacting 2
           isoform c [Homo sapiens]
          Length = 443

 Score =  840 bits (2169), Expect = 0.0
 Identities = 425/443 (95%), Positives = 425/443 (95%), Gaps = 18/443 (4%)

Query: 1   MNLASQSGEAGAGQLLFANFNQDNT------------------SLAVGSKSGYKFFSLSS 42
           MNLASQSGEAGAGQLLFANFNQDNT                  SLAVGSKSGYKFFSLSS
Sbjct: 1   MNLASQSGEAGAGQLLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSS 60

Query: 43  VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL 102
           VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL
Sbjct: 61  VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL 120

Query: 103 AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT 162
           AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT
Sbjct: 121 AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT 180

Query: 163 IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE 222
           IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE
Sbjct: 181 IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE 240

Query: 223 FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM 282
           FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM
Sbjct: 241 FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM 300

Query: 283 ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD 342
           ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD
Sbjct: 301 ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD 360

Query: 343 PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKAYTDDLGAVGGACL 402
           PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKAYTDDLGAVGGACL
Sbjct: 361 PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKAYTDDLGAVGGACL 420

Query: 403 EDEASALRLDEDSEHPPMILRTD 425
           EDEASALRLDEDSEHPPMILRTD
Sbjct: 421 EDEASALRLDEDSEHPPMILRTD 443


>gi|7661580 WD repeat domain, phosphoinositide interacting 2 isoform
           a [Homo sapiens]
          Length = 454

 Score =  831 bits (2147), Expect = 0.0
 Identities = 425/454 (93%), Positives = 425/454 (93%), Gaps = 29/454 (6%)

Query: 1   MNLASQSGEAGAGQLLFANFNQDNT------------------SLAVGSKSGYKFFSLSS 42
           MNLASQSGEAGAGQLLFANFNQDNT                  SLAVGSKSGYKFFSLSS
Sbjct: 1   MNLASQSGEAGAGQLLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSS 60

Query: 43  VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL 102
           VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL
Sbjct: 61  VDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTIL 120

Query: 103 AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT 162
           AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT
Sbjct: 121 AVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSAT 180

Query: 163 IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE 222
           IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE
Sbjct: 181 IGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFE 240

Query: 223 FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM 282
           FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM
Sbjct: 241 FRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLM 300

Query: 283 ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD 342
           ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD
Sbjct: 301 ASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD 360

Query: 343 PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGK-----------AYT 391
           PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGK           AYT
Sbjct: 361 PQEGGECALMKQHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSSPTRLAYT 420

Query: 392 DDLGAVGGACLEDEASALRLDEDSEHPPMILRTD 425
           DDLGAVGGACLEDEASALRLDEDSEHPPMILRTD
Sbjct: 421 DDLGAVGGACLEDEASALRLDEDSEHPPMILRTD 454


>gi|75677340 WD repeat domain, phosphoinositide interacting 2
           isoform e [Homo sapiens]
          Length = 384

 Score =  748 bits (1932), Expect = 0.0
 Identities = 372/372 (100%), Positives = 372/372 (100%)

Query: 54  DTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIV 113
           DTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIV
Sbjct: 13  DTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIV 72

Query: 114 CLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTIN 173
           CLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTIN
Sbjct: 73  CLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTIN 132

Query: 174 LRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSI 233
           LRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSI
Sbjct: 133 LRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSI 192

Query: 234 CSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVT 293
           CSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVT
Sbjct: 193 CSLAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVT 252

Query: 294 EMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMK 353
           EMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMK
Sbjct: 253 EMFNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMK 312

Query: 354 QHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKAYTDDLGAVGGACLEDEASALRLDE 413
           QHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKAYTDDLGAVGGACLEDEASALRLDE
Sbjct: 313 QHRLDGSLETTNEILDSASHDCPLVTQTYGAAAGKAYTDDLGAVGGACLEDEASALRLDE 372

Query: 414 DSEHPPMILRTD 425
           DSEHPPMILRTD
Sbjct: 373 DSEHPPMILRTD 384


>gi|157388939 WD repeat domain, phosphoinositide interacting 1 [Homo
           sapiens]
          Length = 446

 Score =  480 bits (1235), Expect = e-135
 Identities = 245/417 (58%), Positives = 316/417 (75%), Gaps = 16/417 (3%)

Query: 19  NFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAP 78
           +FNQD TSLA G+K+GYK FSLSSV++L+Q++   +  DV IVERLFSSSLV +VS   P
Sbjct: 21  SFNQDCTSLATGTKAGYKLFSLSSVEQLDQVHGSNEIPDVYIVERLFSSSLVVVVSHTKP 80

Query: 79  RKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTIRETPP 138
           R++ V HFKKGTEICNYSYS+ IL+++LNRQRL+VCLEES+YIHNI+DMK+L T+ + P 
Sbjct: 81  RQMNVYHFKKGTEICNYSYSSNILSIRLNRQRLLVCLEESIYIHNIKDMKLLKTLLDIPA 140

Query: 139 NPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTK 198
           NP GLCALSIN+ N YLAYPGS T GE+ ++D  +L+    I AH+  LAA+ F+ASG+K
Sbjct: 141 NPTGLCALSINHSNSYLAYPGSLTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSK 200

Query: 199 LATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFK 258
           LA+ASEKGTVIRVFS+P+GQKL+EFRRG+KR V+I SL FSMD  FL ASSNTETVHIFK
Sbjct: 201 LASASEKGTVIRVFSVPDGQKLYEFRRGMKRYVTISSLVFSMDSQFLCASSNTETVHIFK 260

Query: 259 LETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSL 318
           LE V    PEEP+TW+GY GK+ MA+T+YLP+QV++M +Q RAFAT RL F G +NIC+L
Sbjct: 261 LEQVTNSRPEEPSTWSGYMGKMFMAATNYLPTQVSDMMHQDRAFATARLNFSGQRNICTL 320

Query: 319 ATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMKQHRLDGSLETTNEILDSASHDCPLV 378
           +TIQK+PRLLV ++ G+LYMYNLDPQ+GGEC L+K H L GS  TT E  ++     P +
Sbjct: 321 STIQKLPRLLVASSSGHLYMYNLDPQDGGECVLIKTHSLLGS-GTTEENKENDLR--PSL 377

Query: 379 TQTYGAAAGK----------AYTDDLGAVGGACLEDEASA---LRLDEDSEHPPMIL 422
            Q+Y A   +           Y++D GA+ G  + +   A   + LD+++E PP+IL
Sbjct: 378 PQSYAATVARPSASSASTVPGYSEDGGALRGEVIPEHEFATGPVCLDDENEFPPIIL 434


>gi|122939167 WDR45-like [Homo sapiens]
          Length = 344

 Score =  140 bits (353), Expect = 2e-33
 Identities = 109/345 (31%), Positives = 172/345 (49%), Gaps = 39/345 (11%)

Query: 15  LLFANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVS 74
           LL+A FNQD+   A G ++G++ ++   + + E+  E  +   V  VE LF  + +A+V 
Sbjct: 13  LLYAGFNQDHGCFACGMENGFRVYNTDPLKEKEK-QEFLEG-GVGHVEMLFRCNYLALVG 70

Query: 75  -----LKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESL----YIHNIR 125
                   P K+ +    K   +    +S  + AVKL R R++V L+  +    + HN  
Sbjct: 71  GGKKPKYPPNKVMIWDDLKKKTVIEIEFSTEVKAVKLRRDRIVVVLDSMIKVFTFTHNPH 130

Query: 126 DMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANM-IPAHD 184
            + V     ET  NP GLC L  N++N  LA+PG+ T G VQ+ D  +     + IPAH+
Sbjct: 131 QLHVF----ETCYNPKGLCVLCPNSNNSLLAFPGTHT-GHVQLVDLASTEKPPVDIPAHE 185

Query: 185 SPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMF 244
             L+ +A +  GT++ATASEKGT+IR+F    G  + E RRG  +  +I  + F+ D   
Sbjct: 186 GVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRG-SQAANIYCINFNQDASL 244

Query: 245 LSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVTEMFNQGRAFAT 304
           +  SS+  TVHIF  E  K                  +AS S+LP    + F+   +F+ 
Sbjct: 245 ICVSSDHGTVHIFAAEDPKRNKQSS------------LASASFLP----KYFSSKWSFSK 288

Query: 305 VRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGEC 349
            ++P  G   IC+  T  +   ++   ADG  Y +  +P+  GEC
Sbjct: 289 FQVP-SGSPCICAFGT--EPNAVIAICADGSYYKFLFNPK--GEC 328


>gi|71483646 WD repeat domain 45 isoform 2 [Homo sapiens]
          Length = 360

 Score =  101 bits (251), Expect = 1e-21
 Identities = 70/260 (26%), Positives = 127/260 (48%), Gaps = 19/260 (7%)

Query: 20  FNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPR 79
           FNQD +      ++G + +++  + +   + +      + +VE L  S+L+A+V   +  
Sbjct: 14  FNQDQSCFCCAMETGVRIYNVEPLMEKGHL-DHEQVGSMGLVEMLHRSNLLALVGGGSSP 72

Query: 80  KLKVCHF-----------KKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMK 128
           K                  K   +  ++++  +L+V++   ++++ L+  +Y+++  D  
Sbjct: 73  KFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLKNRIYVYSFPDNP 132

Query: 129 VLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLR-----AANMIPAH 183
                 +T  NP GLC L  + +   L +PG    G +Q+ D  + +     A   I AH
Sbjct: 133 RKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKC-GSLQLVDLASTKPGTSSAPFTINAH 191

Query: 184 DSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGM 243
            S +A ++ +  GT +A+AS+KGT+IR+F     +KL E RRG       C + FS D  
Sbjct: 192 QSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYC-INFSHDSS 250

Query: 244 FLSASSNTETVHIFKLETVK 263
           FL ASS+  TVHIF L+  +
Sbjct: 251 FLCASSDKGTVHIFALKDTR 270


>gi|47059042 WD repeat domain 45 isoform 1 [Homo sapiens]
          Length = 361

 Score =  100 bits (249), Expect = 3e-21
 Identities = 70/261 (26%), Positives = 127/261 (48%), Gaps = 20/261 (7%)

Query: 20  FNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKAPR 79
           FNQD +      ++G + +++  + +   + +      + +VE L  S+L+A+V   +  
Sbjct: 14  FNQDQSCFCCAMETGVRIYNVEPLMEKGHL-DHEQVGSMGLVEMLHRSNLLALVGGGSSP 72

Query: 80  KLKVCHF------------KKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDM 127
           K                   K   +  ++++  +L+V++   ++++ L+  +Y+++  D 
Sbjct: 73  KFSEISAVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLKNRIYVYSFPDN 132

Query: 128 KVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLR-----AANMIPA 182
                  +T  NP GLC L  + +   L +PG    G +Q+ D  + +     A   I A
Sbjct: 133 PRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKC-GSLQLVDLASTKPGTSSAPFTINA 191

Query: 183 HDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDG 242
           H S +A ++ +  GT +A+AS+KGT+IR+F     +KL E RRG       C + FS D 
Sbjct: 192 HQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYC-INFSHDS 250

Query: 243 MFLSASSNTETVHIFKLETVK 263
            FL ASS+  TVHIF L+  +
Sbjct: 251 SFLCASSDKGTVHIFALKDTR 271


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 37/144 (25%), Positives = 69/144 (47%), Gaps = 11/144 (7%)

Query: 140 PAGLCALSINNDNCYLAYPGSATIGE------VQVFDTINLRAANMIPAHDSPLAALAFD 193
           P  + A  + + NC   +P S  +        V+++D +N     +   H  P+ +L F 
Sbjct: 619 PLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFS 678

Query: 194 ASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTET 253
            +G  LAT +  G V+ ++ I  G  + E +       ++CSL FS DG  L++ S   T
Sbjct: 679 PNGRFLATGATDGRVL-LWDIGHGLMVGELKGHTD---TVCSLRFSRDGEILASGSMDNT 734

Query: 254 VHIF-KLETVKEKPPEEPTTWTGY 276
           V ++  ++  ++   ++ TT TG+
Sbjct: 735 VRLWDAIKAFEDLETDDFTTATGH 758


>gi|186928847 cirhin [Homo sapiens]
          Length = 686

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 27/96 (28%), Positives = 48/96 (50%), Gaps = 3/96 (3%)

Query: 170 DTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEG--QKLFEFRRGV 227
           D I+L+  + +PA       + F    TKL  AS +G  + +  +  G  + L  F+   
Sbjct: 423 DNISLKRVSKMPAFLRSALQILFSEDSTKLFVASNQGA-LHIVQLSGGSFKHLHAFQPQS 481

Query: 228 KRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVK 263
               ++C LA S DG +L+AS  +  VH++ ++ +K
Sbjct: 482 GTVEAMCLLAVSPDGNWLAASGTSAGVHVYNVKQLK 517



 Score = 37.0 bits (84), Expect = 0.034
 Identities = 39/147 (26%), Positives = 63/147 (42%), Gaps = 13/147 (8%)

Query: 73  VSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRL-IVCLEESLYIHNIRDMKVLH 131
           +SLK   K+    F +      +S  +T L V  N+  L IV L    + H       LH
Sbjct: 425 ISLKRVSKMPA--FLRSALQILFSEDSTKLFVASNQGALHIVQLSGGSFKH-------LH 475

Query: 132 TIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALA 191
             +        +C L+++ D  +LA   S T   V V++   L+    +PA++ P+ A+A
Sbjct: 476 AFQPQSGTVEAMCLLAVSPDGNWLA--ASGTSAGVHVYNVKQLKLHCTVPAYNFPVTAMA 533

Query: 192 FDASGTKLATASEKGTVIRVFSIPEGQ 218
              +   L  A     V   +SIP+ Q
Sbjct: 534 IAPNTNNLVIAHSDQQVFE-YSIPDKQ 559



 Score = 31.2 bits (69), Expect = 1.9
 Identities = 24/86 (27%), Positives = 42/86 (48%), Gaps = 2/86 (2%)

Query: 164 GEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEF 223
           GE+  +D   L     + A   P+ ++A   SG++L    E G+V ++F I   +  FE 
Sbjct: 81  GEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSV-KLFQITPDKIQFE- 138

Query: 224 RRGVKRCVSICSLAFSMDGMFLSASS 249
           R   ++   I SL++   G  ++A S
Sbjct: 139 RNFDRQKSRILSLSWHPSGTHIAAGS 164


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score = 40.0 bits (92), Expect = 0.004
 Identities = 58/260 (22%), Positives = 104/260 (40%), Gaps = 36/260 (13%)

Query: 116 EESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLR 175
           +++  + ++   K  HT R    + A +  LS N  +  +A     T  ++  +D  N  
Sbjct: 156 DKTCKLWSVETGKCYHTFRG---HTAEIVCLSFNPQSTLVATGSMDTTAKL--WDIQNGE 210

Query: 176 AANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICS 235
               +  H + + +L+F+ SG ++ T S   TV+ V+    G+K+      +  C  I S
Sbjct: 211 EVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVV-VWDADTGRKVNIL---IGHCAEISS 266

Query: 236 LAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVTEM 295
            +F+ D   +   S  +T  ++     K        T TG+  ++L +   Y        
Sbjct: 267 ASFNWDCSLILTGSMDKTCKLWDATNGK-----CVATLTGHDDEILDSCFDY-------- 313

Query: 296 FNQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMKQH 355
              G+  AT      G   I S AT + I +L     +G +   + +PQ          H
Sbjct: 314 --TGKLIATASAD--GTARIFSAATRKCIAKL--EGHEGEISKISFNPQ--------GNH 359

Query: 356 RLDGSLETTNEILDSASHDC 375
            L GS + T  I D+ +  C
Sbjct: 360 LLTGSSDKTARIWDAQTGQC 379


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 38.1 bits (87), Expect = 0.015
 Identities = 35/151 (23%), Positives = 61/151 (40%), Gaps = 22/151 (14%)

Query: 139 NPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTK 198
           +P+G C  +   DN             V+V+D    R       H + +  L+F  SG  
Sbjct: 196 HPSGTCIAAAGMDNT------------VKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 243

Query: 199 LATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFK 258
           L TAS   T +++  + EG+ L+          ++   AFS  G + ++  + E V ++K
Sbjct: 244 LITASSDST-LKILDLMEGRLLYTLHGHQGPATTV---AFSRTGEYFASGGSDEQVMVWK 299

Query: 259 --LETVKE----KPPEEPTTWTGYFGKVLMA 283
              + V      K P  P T     G + ++
Sbjct: 300 SNFDIVDHGEVTKVPRPPATLASSMGNLTVS 330



 Score = 28.9 bits (63), Expect = 9.3
 Identities = 21/78 (26%), Positives = 40/78 (51%), Gaps = 8/78 (10%)

Query: 182 AHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVK--RCVSICSLAFS 239
           AH + + ++ F + G    TAS+  TV +V++    + LF   + +   RC       FS
Sbjct: 101 AHTATVRSVHFCSDGQSFVTASDDKTV-KVWATHRQKFLFSLSQHINWVRCAK-----FS 154

Query: 240 MDGMFLSASSNTETVHIF 257
            DG  + ++S+ +TV ++
Sbjct: 155 PDGRLIVSASDDKTVKLW 172


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 37.7 bits (86), Expect = 0.020
 Identities = 29/120 (24%), Positives = 51/120 (42%), Gaps = 16/120 (13%)

Query: 139 NPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTK 198
           +P+G C  +   DN             V+V+D    R       H + +  L+F  SG  
Sbjct: 158 HPSGTCIAAAGMDNT------------VKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 205

Query: 199 LATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFK 258
           L TAS   T +++  + EG+ L+          ++   AFS  G + ++  + E V ++K
Sbjct: 206 LITASSDST-LKILDLMEGRLLYTLHGHQGPATTV---AFSRTGEYFASGGSDEQVMVWK 261



 Score = 28.9 bits (63), Expect = 9.3
 Identities = 21/78 (26%), Positives = 40/78 (51%), Gaps = 8/78 (10%)

Query: 182 AHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVK--RCVSICSLAFS 239
           AH + + ++ F + G    TAS+  TV +V++    + LF   + +   RC       FS
Sbjct: 63  AHTATVRSVHFCSDGQSFVTASDDKTV-KVWATHRQKFLFSLSQHINWVRCAK-----FS 116

Query: 240 MDGMFLSASSNTETVHIF 257
            DG  + ++S+ +TV ++
Sbjct: 117 PDGRLIVSASDDKTVKLW 134


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 37.7 bits (86), Expect = 0.020
 Identities = 29/120 (24%), Positives = 51/120 (42%), Gaps = 16/120 (13%)

Query: 139 NPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTK 198
           +P+G C  +   DN             V+V+D    R       H + +  L+F  SG  
Sbjct: 196 HPSGTCIAAAGMDNT------------VKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 243

Query: 199 LATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFK 258
           L TAS   T +++  + EG+ L+          ++   AFS  G + ++  + E V ++K
Sbjct: 244 LITASSDST-LKILDLMEGRLLYTLHGHQGPATTV---AFSRTGEYFASGGSDEQVMVWK 299



 Score = 28.9 bits (63), Expect = 9.3
 Identities = 21/78 (26%), Positives = 40/78 (51%), Gaps = 8/78 (10%)

Query: 182 AHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVK--RCVSICSLAFS 239
           AH + + ++ F + G    TAS+  TV +V++    + LF   + +   RC       FS
Sbjct: 101 AHTATVRSVHFCSDGQSFVTASDDKTV-KVWATHRQKFLFSLSQHINWVRCAK-----FS 154

Query: 240 MDGMFLSASSNTETVHIF 257
            DG  + ++S+ +TV ++
Sbjct: 155 PDGRLIVSASDDKTVKLW 172


>gi|153218631 breast carcinoma amplified sequence 3 isoform 1 [Homo
           sapiens]
          Length = 928

 Score = 37.4 bits (85), Expect = 0.026
 Identities = 30/117 (25%), Positives = 49/117 (41%), Gaps = 13/117 (11%)

Query: 162 TIGEVQVFDTINLRAANMI---PAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEG- 217
           T+GE QV  + +  +  ++   PAH+ P+  +AF+ SG  L T    G    VF I    
Sbjct: 326 TVGEGQVLVSEDSDSDGIVAHFPAHEKPVCCMAFNTSGMLLVTTDTLGHDFHVFQILTHP 385

Query: 218 --------QKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKP 266
                     L+   RG      +  + FS D  ++  S+   T H+F +     +P
Sbjct: 386 WSSSQCAVHHLYTLHRGETE-AKVQDICFSHDCRWVVVSTLRGTSHVFPINPYGGQP 441


>gi|153218595 breast carcinoma amplified sequence 3 isoform 2 [Homo
           sapiens]
          Length = 913

 Score = 37.4 bits (85), Expect = 0.026
 Identities = 30/117 (25%), Positives = 49/117 (41%), Gaps = 13/117 (11%)

Query: 162 TIGEVQVFDTINLRAANMI---PAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEG- 217
           T+GE QV  + +  +  ++   PAH+ P+  +AF+ SG  L T    G    VF I    
Sbjct: 326 TVGEGQVLVSEDSDSDGIVAHFPAHEKPVCCMAFNTSGMLLVTTDTLGHDFHVFQILTHP 385

Query: 218 --------QKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEKP 266
                     L+   RG      +  + FS D  ++  S+   T H+F +     +P
Sbjct: 386 WSSSQCAVHHLYTLHRGETE-AKVQDICFSHDCRWVVVSTLRGTSHVFPINPYGGQP 441


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score = 35.0 bits (79), Expect = 0.13
 Identities = 26/78 (33%), Positives = 41/78 (52%), Gaps = 8/78 (10%)

Query: 182 AHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVK--RCVSICSLAFS 239
           AH +P+ ++ F A G  LATASE  + I+V+S+   + L+   R     RC       FS
Sbjct: 100 AHTAPVRSVDFSADGQFLATASEDKS-IKVWSMYRQRFLYSLYRHTHWVRCAK-----FS 153

Query: 240 MDGMFLSASSNTETVHIF 257
            DG  + + S  +T+ I+
Sbjct: 154 PDGRLIVSCSEDKTIKIW 171



 Score = 33.9 bits (76), Expect = 0.29
 Identities = 27/117 (23%), Positives = 52/117 (44%), Gaps = 17/117 (14%)

Query: 139 NPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTK 198
           NP+G C  S  +D              V+V+D    +       H   +  ++F  SG  
Sbjct: 195 NPSGTCIASAGSDQT------------VKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNY 242

Query: 199 LATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDG-MFLSASSNTETV 254
           L TAS  GT +++  + EG+ ++  +        + +++FS  G +F S  ++T+ +
Sbjct: 243 LITASSDGT-LKILDLLEGRLIYTLQ---GHTGPVFTVSFSKGGELFASGGADTQVL 295



 Score = 32.3 bits (72), Expect = 0.84
 Identities = 21/77 (27%), Positives = 39/77 (50%), Gaps = 4/77 (5%)

Query: 183 HDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDG 242
           H   + ++ F   G  LA+AS   TV R++   +  K  EF+        + S+ FS DG
Sbjct: 59  HKDVVTSVQFSPHGNLLASASRDRTV-RLWIPDKRGKFSEFKA---HTAPVRSVDFSADG 114

Query: 243 MFLSASSNTETVHIFKL 259
            FL+ +S  +++ ++ +
Sbjct: 115 QFLATASEDKSIKVWSM 131


>gi|5901892 WD repeat and HMG-box DNA binding protein 1 isoform 1
           [Homo sapiens]
          Length = 1129

 Score = 34.3 bits (77), Expect = 0.22
 Identities = 28/101 (27%), Positives = 48/101 (47%), Gaps = 6/101 (5%)

Query: 166 VQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPE-----GQKL 220
           V++ D ++         HD+P+ +L+FD     LA+AS  G+V RV+ I +        L
Sbjct: 118 VKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSV-RVWQISDQTCAISWPL 176

Query: 221 FEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLET 261
            +    V    SIC LA+      L A    ++V +++ E+
Sbjct: 177 LQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRES 217


>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
           sapiens]
          Length = 504

 Score = 34.3 bits (77), Expect = 0.22
 Identities = 24/102 (23%), Positives = 48/102 (47%), Gaps = 6/102 (5%)

Query: 159 GSATI-GEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEG 217
           G+ T+  +++++D          P H  P+ ++AF  +G  LATA++  +V     + + 
Sbjct: 366 GTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSV----KLWDL 421

Query: 218 QKLFEFRR-GVKRCVSICSLAFSMDGMFLSASSNTETVHIFK 258
           +KL  F+   +     + SL F   G +L+       ++I K
Sbjct: 422 RKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICK 463


>gi|14150171 THO complex 3 [Homo sapiens]
          Length = 351

 Score = 34.3 bits (77), Expect = 0.22
 Identities = 32/117 (27%), Positives = 52/117 (44%), Gaps = 8/117 (6%)

Query: 146 LSINNDN-CYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASE 204
           +S NNDN  +    G+   G + +     L+    I AH S    + FD  G   AT S 
Sbjct: 188 ISWNNDNNMFFLTNGN---GCINILSYPELKPVQSINAHPSNCICIKFDPMGKYFATGSA 244

Query: 205 KGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLET 261
              V    S+ +  +L   R   +    + +L+FS DG  L+++S    + I ++ET
Sbjct: 245 DALV----SLWDVDELVCVRCFSRLDWPVRTLSFSHDGKMLASASEDHFIDIAEVET 297


>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
           sapiens]
          Length = 513

 Score = 33.1 bits (74), Expect = 0.49
 Identities = 23/80 (28%), Positives = 39/80 (48%), Gaps = 3/80 (3%)

Query: 184 DSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGM 243
           D  +  + F      LAT ++ G  I+V+ I  GQ L  F R   +   +  L+FS D  
Sbjct: 264 DDAVLCMCFSRDTEMLATGAQDGK-IKVWKIQSGQCLRRFERAHSK--GVTCLSFSKDSS 320

Query: 244 FLSASSNTETVHIFKLETVK 263
            + ++S  +T+ I  L++ K
Sbjct: 321 QILSASFDQTIRIHGLKSGK 340


>gi|13376840 WD repeat domain 61 [Homo sapiens]
          Length = 305

 Score = 32.7 bits (73), Expect = 0.64
 Identities = 25/119 (21%), Positives = 52/119 (43%), Gaps = 6/119 (5%)

Query: 143 LCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATA 202
           + +++ + D  YLA    A  G + +FD    +  + +  H  P+ +L F      L TA
Sbjct: 151 ILSIAYSPDGKYLA--SGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTA 208

Query: 203 SEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLET 261
           S+ G  I+++ +                  + ++AF  D     +SS+ ++V ++ + T
Sbjct: 209 SDDG-YIKIYDVQHANLAGTLS---GHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGT 263



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 41/164 (25%), Positives = 73/164 (44%), Gaps = 18/164 (10%)

Query: 187 LAALAFDASGT-KLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFL 245
           L  ++ D S T  +A +S     IR++ +  G+++     G    V   +LAFS D  +L
Sbjct: 65  LGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGP---VDAWTLAFSPDSQYL 121

Query: 246 SASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLMA-----STSYLPSQVTEMFNQGR 300
           +  ++   V+IF +E+ K++   +        GK +++        YL S   +      
Sbjct: 122 ATGTHVGKVNIFGVESGKKEYSLDTR------GKFILSIAYSPDGKYLASGAIDGIINIF 175

Query: 301 AFATVRL--PFCGHKNICSLATIQKIPRLLVGAA-DGYLYMYNL 341
             AT +L     GH       T     +LLV A+ DGY+ +Y++
Sbjct: 176 DIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDV 219


>gi|148528998 Dmx-like 1 [Homo sapiens]
          Length = 3027

 Score = 32.7 bits (73), Expect = 0.64
 Identities = 33/141 (23%), Positives = 55/141 (39%), Gaps = 9/141 (6%)

Query: 74   SLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVLHTI 133
            S+  P     CH K   +    S S+ I    L+     VCL ++L             +
Sbjct: 2826 SMPKPYLTWQCHNKTANDFVFVSSSSLIATAGLSTDNRNVCLWDTLVA------PANSLV 2879

Query: 134  RETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFD 193
                 + +G   L+    +  L   G    G   VFD    +   +  +HDSP+ A+A D
Sbjct: 2880 HAFTCHDSGATVLAYAPKHQLLISGGRK--GFTYVFDLCQRQQRQLFQSHDSPVKAVAVD 2937

Query: 194  ASGTKLATASEKGTVIRVFSI 214
             +     T S +G  I+++S+
Sbjct: 2938 PTEEYFVTGSAEGN-IKIWSL 2957


>gi|157739942 gemin 5 [Homo sapiens]
          Length = 1508

 Score = 32.3 bits (72), Expect = 0.84
 Identities = 32/125 (25%), Positives = 56/125 (44%), Gaps = 10/125 (8%)

Query: 180 IPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSIC---SL 236
           +P H      +++ A G  +A  +E G+ I +F IP  + +   ++  K   +I      
Sbjct: 536 LPVHTE----ISWKADGKIMALGNEDGS-IEIFQIPNLKLICTIQQHHKLVNTISWHHEH 590

Query: 237 AFSMDGMFLSAS-SNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVTEM 295
               +  +L AS SN   +++  L+TV E  PE P T T  + + L   T+ + S     
Sbjct: 591 GSQPELSYLMASGSNNAVIYVHNLKTVIESSPESPVTITEPY-RTLSGHTAKITSVAWSP 649

Query: 296 FNQGR 300
            + GR
Sbjct: 650 HHDGR 654


>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
           [Homo sapiens]
          Length = 340

 Score = 32.3 bits (72), Expect = 0.84
 Identities = 24/91 (26%), Positives = 40/91 (43%), Gaps = 2/91 (2%)

Query: 157 YPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPE 216
           +   A    ++++D  +         H+S + A+AF  +G    T S+  T  R+F +  
Sbjct: 199 FVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDAT-CRLFDLRA 257

Query: 217 GQKLFEFRRGVKRCVSICSLAFSMDGMFLSA 247
            Q+L  +      C  I S+AFS  G  L A
Sbjct: 258 DQELLMYSHDNIIC-GITSVAFSRSGRLLLA 287


>gi|38569484 kinesin family member 21A [Homo sapiens]
          Length = 1661

 Score = 31.6 bits (70), Expect = 1.4
 Identities = 56/277 (20%), Positives = 106/277 (38%), Gaps = 42/277 (15%)

Query: 79   RKLKVCHFKKGTEICNYS-YSNTILAVKLNRQRLIVCLEESLYIH--NIRDM-KVLHTIR 134
            R  KV +   G EI +   + N +++VK      +V    + YI   +IRD  K + T+ 
Sbjct: 1354 RTCKVWNLVTGQEIMSLGGHPNNVVSVKYCNYTSLVFTVSTSYIKVWDIRDSAKCIRTLT 1413

Query: 135  ETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDA 194
             +                      G  T+G+     T    A   IP+ ++ +  +A + 
Sbjct: 1414 SS----------------------GQVTLGDACSASTSRTVA---IPSGENQINQIALNP 1448

Query: 195  SGTKLATASEKGTVIRVFSIPEGQKLFEF--RRGVKRCVSICSLAFSMDGMFLSASSNTE 252
            +GT L  AS  G  +R++ +   Q   +     G   C+++  ++   D   +   S   
Sbjct: 1449 TGTFLYAAS--GNAVRMWDLKRFQSTGKLTGHLGPVMCLTVDQISSGQD--LIITGSKDH 1504

Query: 253  TVHIFK-----LETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVT--EMFNQGRAFATV 305
             + +F      L TV      EP  + G     +     +  S+    + ++  +     
Sbjct: 1505 YIKMFDVTEGALGTVSPTHNFEPPHYDGIEALTIQGDNLFSGSRDNGIKKWDLTQKDLLQ 1564

Query: 306  RLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLD 342
            ++P      +C+L  +   P LL G   G L ++N+D
Sbjct: 1565 QVPNAHKDWVCALGVVPDHPVLLSGCRGGILKVWNMD 1601


>gi|56550086 WD repeat and HMG-box DNA binding protein 1 isoform 2
           [Homo sapiens]
          Length = 1006

 Score = 31.6 bits (70), Expect = 1.4
 Identities = 26/84 (30%), Positives = 42/84 (50%), Gaps = 6/84 (7%)

Query: 183 HDSPLAALAFDASGTKLATASEKGTVIRVFSIPE-----GQKLFEFRRGVKRCVSICSLA 237
           HD+P+ +L+FD     LA+AS  G+V RV+ I +        L +    V    SIC LA
Sbjct: 12  HDAPVLSLSFDPKDIFLASASCDGSV-RVWQISDQTCAISWPLLQKCNDVINAKSICRLA 70

Query: 238 FSMDGMFLSASSNTETVHIFKLET 261
           +      L A    ++V +++ E+
Sbjct: 71  WQPKSGKLLAIPVEKSVKLYRRES 94


>gi|94400919 WD repeat domain 90 [Homo sapiens]
          Length = 1748

 Score = 31.6 bits (70), Expect = 1.4
 Identities = 18/60 (30%), Positives = 34/60 (56%), Gaps = 1/60 (1%)

Query: 164 GEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEF 223
           G +   DT++     +  +H +P+ ALA +    +LAT S+  TV R++ +   Q+L++F
Sbjct: 680 GHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATVSQDRTV-RIWDLATLQQLYDF 738


>gi|21541824 transducin-like enhancer protein 1 [Homo sapiens]
          Length = 770

 Score = 31.2 bits (69), Expect = 1.9
 Identities = 27/98 (27%), Positives = 41/98 (41%), Gaps = 8/98 (8%)

Query: 164 GEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEF 223
           G + V+D  N         H    + +     GTKL T     TV R + + EG++L + 
Sbjct: 596 GNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTV-RSWDLREGRQLQQH 654

Query: 224 RRGVKRCVSICSLAFSMDGMFLSA---SSNTETVHIFK 258
                    I SL +   G +L+    SSN E +H+ K
Sbjct: 655 ----DFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNK 688


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.133    0.390 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,145,314
Number of Sequences: 37866
Number of extensions: 677149
Number of successful extensions: 1529
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 36
Number of HSP's that attempted gapping in prelim test: 1455
Number of HSP's gapped (non-prelim): 94
length of query: 425
length of database: 18,247,518
effective HSP length: 105
effective length of query: 320
effective length of database: 14,271,588
effective search space: 4566908160
effective search space used: 4566908160
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.