Search of human proteins with 71143127

Search of human proteins with 71143127

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]
         (759 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]                1487   0.0  
gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]      605   e-173
gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]       605   e-173
gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]       573   e-163
gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]       573   e-163
gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]                     160   5e-39
gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]                       160   5e-39
gi|4758968 cytohesin 3 [Homo sapiens]                                 157   3e-38
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]                     156   6e-38
gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]                       156   6e-38
gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange pr...   150   4e-36
gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange...   149   7e-36
gi|4758416 golgi-specific brefeldin A resistant guanine nucleoti...   136   6e-32
gi|7019505 cytohesin 4 [Homo sapiens]                                 135   1e-31
gi|48928044 F-box only protein 8 [Homo sapiens]                       104   3e-22
gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]      101   3e-21
gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6 ...    91   4e-18
gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6...    91   4e-18
gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]     91   4e-18
gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]     89   2e-17
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        49   2e-05
gi|27894378 chloride intracellular channel 6 [Homo sapiens]            48   3e-05
gi|167234429 zinc finger and BTB domain containing 17 [Homo sapi...    46   1e-04
gi|153070260 myristoylated alanine-rich protein kinase C substra...    44   4e-04
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              44   6e-04
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     43   0.001
gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo sap...    42   0.003
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]       42   0.003
gi|73476377 LBXCOR1 homolog [Homo sapiens]                             42   0.003
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]         42   0.003

>gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]
          Length = 759

 Score = 1487 bits (3849), Expect = 0.0
 Identities = 759/759 (100%), Positives = 759/759 (100%)

Query: 1   MLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISLRKVRSPTAES 60
           MLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISLRKVRSPTAES
Sbjct: 1   MLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISLRKVRSPTAES 60

Query: 61  LAAEKALMEGYGLVGLPLVRSPSLPPTFAGTLTELEDSFTEQVQSLAKSIDDALSTWSLK 120
           LAAEKALMEGYGLVGLPLVRSPSLPPTFAGTLTELEDSFTEQVQSLAKSIDDALSTWSLK
Sbjct: 61  LAAEKALMEGYGLVGLPLVRSPSLPPTFAGTLTELEDSFTEQVQSLAKSIDDALSTWSLK 120

Query: 121 TMCSLRESGAYQLHQALQAAAGPPGLEAEGRAPESAGPGPGDDAAETPGLPPAHSGTLMM 180
           TMCSLRESGAYQLHQALQAAAGPPGLEAEGRAPESAGPGPGDDAAETPGLPPAHSGTLMM
Sbjct: 121 TMCSLRESGAYQLHQALQAAAGPPGLEAEGRAPESAGPGPGDDAAETPGLPPAHSGTLMM 180

Query: 181 AFRDVTVQIANQNISVSSSTALSVANCLGAQTVQAPAEPAAGKAEQGETSGREAPEAPAV 240
           AFRDVTVQIANQNISVSSSTALSVANCLGAQTVQAPAEPAAGKAEQGETSGREAPEAPAV
Sbjct: 181 AFRDVTVQIANQNISVSSSTALSVANCLGAQTVQAPAEPAAGKAEQGETSGREAPEAPAV 240

Query: 241 GREDASAEDSCAEAAASGAADGATAPKTEEEEEEEETAEVGRGAEAEAGDLEQLSSSSTS 300
           GREDASAEDSCAEAAASGAADGATAPKTEEEEEEEETAEVGRGAEAEAGDLEQLSSSSTS
Sbjct: 241 GREDASAEDSCAEAAASGAADGATAPKTEEEEEEEETAEVGRGAEAEAGDLEQLSSSSTS 300

Query: 301 TKSAKSGSEASASASKDALQAMILSLPRYHCENPASCKSPTLSTDTLRKRLYRIGLNLFN 360
           TKSAKSGSEASASASKDALQAMILSLPRYHCENPASCKSPTLSTDTLRKRLYRIGLNLFN
Sbjct: 301 TKSAKSGSEASASASKDALQAMILSLPRYHCENPASCKSPTLSTDTLRKRLYRIGLNLFN 360

Query: 361 INPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDE 420
           INPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDE
Sbjct: 361 INPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDE 420

Query: 421 MDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILA 480
           MDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILA
Sbjct: 421 MDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILA 480

Query: 481 FAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELKSNE 540
           FAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELKSNE
Sbjct: 481 FAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELKSNE 540

Query: 541 DHVTYVTKVEKSIVGMKTVLSVPHRRLVCCSRLFEVTDVNKLQKQAAHQREVFLFNDLLV 600
           DHVTYVTKVEKSIVGMKTVLSVPHRRLVCCSRLFEVTDVNKLQKQAAHQREVFLFNDLLV
Sbjct: 541 DHVTYVTKVEKSIVGMKTVLSVPHRRLVCCSRLFEVTDVNKLQKQAAHQREVFLFNDLLV 600

Query: 601 ILKLCPKKKSSSTYTFCKSVGLLGMQFQLFENEYYSHGITLVTPLSGSEKKQVLHFCALG 660
           ILKLCPKKKSSSTYTFCKSVGLLGMQFQLFENEYYSHGITLVTPLSGSEKKQVLHFCALG
Sbjct: 601 ILKLCPKKKSSSTYTFCKSVGLLGMQFQLFENEYYSHGITLVTPLSGSEKKQVLHFCALG 660

Query: 661 SDEMQKFVEDLKESIAEVTELEQIRIEWELEKQQGTKTLSFKPCGAQGDPQSKQGSPTAK 720
           SDEMQKFVEDLKESIAEVTELEQIRIEWELEKQQGTKTLSFKPCGAQGDPQSKQGSPTAK
Sbjct: 661 SDEMQKFVEDLKESIAEVTELEQIRIEWELEKQQGTKTLSFKPCGAQGDPQSKQGSPTAK 720

Query: 721 REAALRERPAESTVEVLINASPARLTILPISRDTIKSYC 759
           REAALRERPAESTVEVLINASPARLTILPISRDTIKSYC
Sbjct: 721 REAALRERPAESTVEVLINASPARLTILPISRDTIKSYC 759


>gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]
          Length = 1114

 Score =  605 bits (1559), Expect = e-173
 Identities = 368/789 (46%), Positives = 470/789 (59%), Gaps = 102/789 (12%)

Query: 1   MLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISLRKVR------ 54
           MLE KYGG LV+R AA TIQTAFRQYQ++KNFE++R+S+ E+R+ RRI L  +R      
Sbjct: 109 MLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFE 168

Query: 55  ---------------SPTAESLAAEKALMEGYGLVGLPL-VRSPSLPPTFAGTLTELEDS 98
                          S T +       +    G +  P  ++SP+    FA  +TELED+
Sbjct: 169 GPEKVHSSYFEGKQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDA 228

Query: 99  FTEQVQSLAKSID----------------DALSTWSLKTMCSLRESGAYQLHQAL----- 137
           F+ QV+SLA+SID                DA      +   +L      +L +       
Sbjct: 229 FSRQVKSLAESIDDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSD 288

Query: 138 -----------------QAAAGPPGLEAE------GRAPESAGPGPGDDAAET------- 167
                            QA   P   E++      G AP+       +D A+T       
Sbjct: 289 VTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRST 348

Query: 168 PGLPPAHSGTLMMAFRDVTVQIANQNISVSSSTALSVANCLGAQTVQAPAEPAAGKAEQG 227
           P L        +     +T++  +      SS  LS  +  G+   Q+  E + G  +  
Sbjct: 349 PSLERQEQRLRVEHLPLLTIEPPSD-----SSVDLSDRSERGSLKRQSAYERSLGGQQGS 403

Query: 228 ETSGREAPEAPAVGREDASAEDSCAEAAASGAADGATAPKTEEEEEEEETAEVGRGAEAE 287
              G  +    ++ RE+            S  A   +A +  + E +             
Sbjct: 404 PKHGPHSGAPKSLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSD---------- 453

Query: 288 AGDLEQLSSSSTSTKSAKSGSEASASASKDALQAMILSLPRYHCENPASCKSPTLSTDTL 347
            GD + ++S+S S  +    SE+S   S+D+L+   LS   YH E   S  SP  S D +
Sbjct: 454 -GDNDSINSTSNSNDTINCSSESS---SRDSLREQTLSKQTYHKEARNSWDSPAFSNDVI 509

Query: 348 RKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKK 407
           RKR YRIGLNLFN  P+KG+Q+LI RGF+PDTP+GVAHFLLQRKGLSRQMIGEFLGN +K
Sbjct: 510 RKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQK 569

Query: 408 QFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVV 467
           QFNRDVLDCVVDEMDFS+MELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYC+CNP VV
Sbjct: 570 QFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVV 629

Query: 468 QQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGI 527
           +QF NPDTIFILAFAIILLNTDMYSPN+KP+RKM LEDFI+NLRGVDDG DIPRE+++GI
Sbjct: 630 RQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI 689

Query: 528 YERIQQKELKSNEDHVTYVTKVEKSIVGMK----------TVLSVPHRRLVCCSRLFEVT 577
           YERI+++ELK+NEDHV+ V KVEK IVG K           VLS+PHRRLVC  RLFEV 
Sbjct: 690 YERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVP 749

Query: 578 DVNKLQKQAAHQREVFLFNDLLVILKLCPKKKSSSTYTFCKSVGLLGMQFQLFENEYYSH 637
           D NK QK   HQRE+FLFNDLLV+ K+  KKK+S TY+F +S  L GMQ  LFEN+YY +
Sbjct: 750 DPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPN 809

Query: 638 GITLVTPLSGSEKKQVLHFCALGSDEMQKFVEDLKESIAEVTELEQIRIEWELEKQQGTK 697
           GI L + + G++ K +++F A    + +KF +DL+ESIAEV E+E+ RIE ELEKQ+G  
Sbjct: 810 GIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQKGVV 869

Query: 698 TLSFKPCGA 706
             S   C +
Sbjct: 870 RPSMSQCSS 878


>gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]
          Length = 963

 Score =  605 bits (1559), Expect = e-173
 Identities = 368/789 (46%), Positives = 470/789 (59%), Gaps = 102/789 (12%)

Query: 1   MLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISLRKVR------ 54
           MLE KYGG LV+R AA TIQTAFRQYQ++KNFE++R+S+ E+R+ RRI L  +R      
Sbjct: 123 MLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFE 182

Query: 55  ---------------SPTAESLAAEKALMEGYGLVGLPL-VRSPSLPPTFAGTLTELEDS 98
                          S T +       +    G +  P  ++SP+    FA  +TELED+
Sbjct: 183 GPEKVHSSYFEGKQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDA 242

Query: 99  FTEQVQSLAKSID----------------DALSTWSLKTMCSLRESGAYQLHQAL----- 137
           F+ QV+SLA+SID                DA      +   +L      +L +       
Sbjct: 243 FSRQVKSLAESIDDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSD 302

Query: 138 -----------------QAAAGPPGLEAE------GRAPESAGPGPGDDAAET------- 167
                            QA   P   E++      G AP+       +D A+T       
Sbjct: 303 VTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRST 362

Query: 168 PGLPPAHSGTLMMAFRDVTVQIANQNISVSSSTALSVANCLGAQTVQAPAEPAAGKAEQG 227
           P L        +     +T++  +      SS  LS  +  G+   Q+  E + G  +  
Sbjct: 363 PSLERQEQRLRVEHLPLLTIEPPSD-----SSVDLSDRSERGSLKRQSAYERSLGGQQGS 417

Query: 228 ETSGREAPEAPAVGREDASAEDSCAEAAASGAADGATAPKTEEEEEEEETAEVGRGAEAE 287
              G  +    ++ RE+            S  A   +A +  + E +             
Sbjct: 418 PKHGPHSGAPKSLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSD---------- 467

Query: 288 AGDLEQLSSSSTSTKSAKSGSEASASASKDALQAMILSLPRYHCENPASCKSPTLSTDTL 347
            GD + ++S+S S  +    SE+S   S+D+L+   LS   YH E   S  SP  S D +
Sbjct: 468 -GDNDSINSTSNSNDTINCSSESS---SRDSLREQTLSKQTYHKEARNSWDSPAFSNDVI 523

Query: 348 RKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKK 407
           RKR YRIGLNLFN  P+KG+Q+LI RGF+PDTP+GVAHFLLQRKGLSRQMIGEFLGN +K
Sbjct: 524 RKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQK 583

Query: 408 QFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVV 467
           QFNRDVLDCVVDEMDFS+MELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYC+CNP VV
Sbjct: 584 QFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVV 643

Query: 468 QQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGI 527
           +QF NPDTIFILAFAIILLNTDMYSPN+KP+RKM LEDFI+NLRGVDDG DIPRE+++GI
Sbjct: 644 RQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI 703

Query: 528 YERIQQKELKSNEDHVTYVTKVEKSIVGMK----------TVLSVPHRRLVCCSRLFEVT 577
           YERI+++ELK+NEDHV+ V KVEK IVG K           VLS+PHRRLVC  RLFEV 
Sbjct: 704 YERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVP 763

Query: 578 DVNKLQKQAAHQREVFLFNDLLVILKLCPKKKSSSTYTFCKSVGLLGMQFQLFENEYYSH 637
           D NK QK   HQRE+FLFNDLLV+ K+  KKK+S TY+F +S  L GMQ  LFEN+YY +
Sbjct: 764 DPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPN 823

Query: 638 GITLVTPLSGSEKKQVLHFCALGSDEMQKFVEDLKESIAEVTELEQIRIEWELEKQQGTK 697
           GI L + + G++ K +++F A    + +KF +DL+ESIAEV E+E+ RIE ELEKQ+G  
Sbjct: 824 GIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQKGVV 883

Query: 698 TLSFKPCGA 706
             S   C +
Sbjct: 884 RPSMSQCSS 892


>gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]
          Length = 949

 Score =  573 bits (1476), Expect = e-163
 Identities = 360/777 (46%), Positives = 457/777 (58%), Gaps = 94/777 (12%)

Query: 1   MLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISL---------- 50
           MLE KYGG  +SRRAA TIQTAFRQY+++KNFE++R+S  ESR+ RRI L          
Sbjct: 131 MLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFE 190

Query: 51  --RKVRSPT----------------AESLAAEKALMEGYGLVGLPLVRSPSLPPT---FA 89
              K ++P                 A S   E+ L  G G  G  +    S   T   F+
Sbjct: 191 EYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYG-GSCGGGIDGGGSSVTTSGEFS 249

Query: 90  GTLTELEDSFTEQVQSLAKSIDDALSTWSLKTMCS--------LRESGAYQLHQALQAAA 141
             +TELEDSF++QV+SLA+SID+AL+      M           RES   Q   +  + +
Sbjct: 250 NDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFS 309

Query: 142 GPP-------GLEAEGRAPESAGPGPGDD-----AAETPGLPPAHSGTL----------- 178
             P         ++  R P +  P  G       A   P  PP  SGT            
Sbjct: 310 DLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRR 369

Query: 179 ---MMAFRDVTVQIANQNISV-----SSSTALSVANCLGAQTVQAPAEPAA----GKAEQ 226
               +  RD  ++ A+  +        SS  LS  +  G+   Q   E       G  + 
Sbjct: 370 GPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKH 429

Query: 227 GETSGRE--------APEAPAVGREDASAEDSCAEAAASGAADGATAPKTEEEEEEEETA 278
               GR         APE PA            +    SG A G    K E         
Sbjct: 430 KGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCE--------- 480

Query: 279 EVGRGAEAEAGDLEQLSSSSTSTKSAKSGSEASASASKDALQAMILSLPRYHCENPASCK 338
               G  ++ GD E L SSS S ++    S +S+  S     A  L    Y  E   S  
Sbjct: 481 --AAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWD 538

Query: 339 SPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMI 398
           SP  + D +++R YRIGLNLFN  P+KGIQ+LI RGF+ DTP+GVAHF+L+RKGLSRQMI
Sbjct: 539 SPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMI 598

Query: 399 GEFLGNSKKQFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQR 458
           GEFLGN +KQFNRDVLDCVVDEMDFSSM+LD+ALRKFQ+HIRVQGEAQKVERLIEAFSQR
Sbjct: 599 GEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQR 658

Query: 459 YCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGAD 518
           YC+CNP +V+QF NPDTIFILAFAIILLNTDMYSP++K +RKM L+DFI+NLRGVD+G D
Sbjct: 659 YCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGED 718

Query: 519 IPRELVVGIYERIQQKELKSNEDHVTYVTKVEKSIVGMKTVLSVPHRRLVCCSRLFEVTD 578
           IPR+L+VGIY+RIQ +EL++N+DHV+ V  VE+ IVG K VLS+PHRRLVCC +L+EV D
Sbjct: 719 IPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPD 778

Query: 579 VNKLQKQAAHQREVFLFNDLLVILKLCPKKKSSSTYTFCKSVGLLGMQFQLFENEYYSHG 638
            N+ Q+   HQREVFLFNDLLV+ K+  KKK   TY+F +S  L+ M  QLF+N YY  G
Sbjct: 779 PNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFG 838

Query: 639 ITLVTPLSGSEKKQVLHFCALGSDEMQKFVEDLKESIAEVTELEQIRIEWELEKQQG 695
           I L++ + G E+K ++ F A    +  +F  DL+ESIAEV E+E+ R+E ELEKQ+G
Sbjct: 839 IKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKG 895


>gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]
          Length = 1488

 Score =  573 bits (1476), Expect = e-163
 Identities = 360/777 (46%), Positives = 457/777 (58%), Gaps = 94/777 (12%)

Query: 1    MLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISL---------- 50
            MLE KYGG  +SRRAA TIQTAFRQY+++KNFE++R+S  ESR+ RRI L          
Sbjct: 336  MLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFE 395

Query: 51   --RKVRSPT----------------AESLAAEKALMEGYGLVGLPLVRSPSLPPT---FA 89
               K ++P                 A S   E+ L  G G  G  +    S   T   F+
Sbjct: 396  EYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYG-GSCGGGIDGGGSSVTTSGEFS 454

Query: 90   GTLTELEDSFTEQVQSLAKSIDDALSTWSLKTMCS--------LRESGAYQLHQALQAAA 141
              +TELEDSF++QV+SLA+SID+AL+      M           RES   Q   +  + +
Sbjct: 455  NDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFS 514

Query: 142  GPP-------GLEAEGRAPESAGPGPGDD-----AAETPGLPPAHSGTL----------- 178
              P         ++  R P +  P  G       A   P  PP  SGT            
Sbjct: 515  DLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRR 574

Query: 179  ---MMAFRDVTVQIANQNISV-----SSSTALSVANCLGAQTVQAPAEPAA----GKAEQ 226
                +  RD  ++ A+  +        SS  LS  +  G+   Q   E       G  + 
Sbjct: 575  GPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKH 634

Query: 227  GETSGRE--------APEAPAVGREDASAEDSCAEAAASGAADGATAPKTEEEEEEEETA 278
                GR         APE PA            +    SG A G    K E         
Sbjct: 635  KGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCE--------- 685

Query: 279  EVGRGAEAEAGDLEQLSSSSTSTKSAKSGSEASASASKDALQAMILSLPRYHCENPASCK 338
                G  ++ GD E L SSS S ++    S +S+  S     A  L    Y  E   S  
Sbjct: 686  --AAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWD 743

Query: 339  SPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMI 398
            SP  + D +++R YRIGLNLFN  P+KGIQ+LI RGF+ DTP+GVAHF+L+RKGLSRQMI
Sbjct: 744  SPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMI 803

Query: 399  GEFLGNSKKQFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQR 458
            GEFLGN +KQFNRDVLDCVVDEMDFSSM+LD+ALRKFQ+HIRVQGEAQKVERLIEAFSQR
Sbjct: 804  GEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQR 863

Query: 459  YCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGAD 518
            YC+CNP +V+QF NPDTIFILAFAIILLNTDMYSP++K +RKM L+DFI+NLRGVD+G D
Sbjct: 864  YCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGED 923

Query: 519  IPRELVVGIYERIQQKELKSNEDHVTYVTKVEKSIVGMKTVLSVPHRRLVCCSRLFEVTD 578
            IPR+L+VGIY+RIQ +EL++N+DHV+ V  VE+ IVG K VLS+PHRRLVCC +L+EV D
Sbjct: 924  IPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPD 983

Query: 579  VNKLQKQAAHQREVFLFNDLLVILKLCPKKKSSSTYTFCKSVGLLGMQFQLFENEYYSHG 638
             N+ Q+   HQREVFLFNDLLV+ K+  KKK   TY+F +S  L+ M  QLF+N YY  G
Sbjct: 984  PNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFG 1043

Query: 639  ITLVTPLSGSEKKQVLHFCALGSDEMQKFVEDLKESIAEVTELEQIRIEWELEKQQG 695
            I L++ + G E+K ++ F A    +  +F  DL+ESIAEV E+E+ R+E ELEKQ+G
Sbjct: 1044 IKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKG 1100


>gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
          Length = 399

 Score =  160 bits (404), Expect = 5e-39
 Identities = 80/194 (41%), Positives = 129/194 (66%), Gaps = 6/194 (3%)

Query: 348 RKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKK 407
           R R   +G   FN++P KGIQFL+    + +TP  +A FL + +GL++  IG++LG  ++
Sbjct: 61  RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGE-RE 119

Query: 408 QFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVV 467
           + N  VL   VD  +F+ + L +ALR+F    R+ GEAQK++R++EAF+QRYC+CNP V 
Sbjct: 120 ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGV- 178

Query: 468 QQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGI 527
             F + DT ++L+FA+I+LNT +++PN++   K  LE F+   RG+++G D+P EL+  +
Sbjct: 179 --FQSTDTCYVLSFAVIMLNTSLHNPNVRD--KPGLERFVAMNRGINEGGDLPEELLRNL 234

Query: 528 YERIQQKELKSNED 541
           Y+ I+ +  K  ED
Sbjct: 235 YDSIRNEPFKIPED 248


>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
          Length = 400

 Score =  160 bits (404), Expect = 5e-39
 Identities = 80/194 (41%), Positives = 129/194 (66%), Gaps = 6/194 (3%)

Query: 348 RKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKK 407
           R R   +G   FN++P KGIQFL+    + +TP  +A FL + +GL++  IG++LG  ++
Sbjct: 61  RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGE-RE 119

Query: 408 QFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVV 467
           + N  VL   VD  +F+ + L +ALR+F    R+ GEAQK++R++EAF+QRYC+CNP V 
Sbjct: 120 ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGV- 178

Query: 468 QQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGI 527
             F + DT ++L+FA+I+LNT +++PN++   K  LE F+   RG+++G D+P EL+  +
Sbjct: 179 --FQSTDTCYVLSFAVIMLNTSLHNPNVRD--KPGLERFVAMNRGINEGGDLPEELLRNL 234

Query: 528 YERIQQKELKSNED 541
           Y+ I+ +  K  ED
Sbjct: 235 YDSIRNEPFKIPED 248


>gi|4758968 cytohesin 3 [Homo sapiens]
          Length = 399

 Score =  157 bits (398), Expect = 3e-38
 Identities = 95/284 (33%), Positives = 151/284 (53%), Gaps = 35/284 (12%)

Query: 258 GAADGATAPKTEEEEEEEETAEVGRGAEAEAGDLEQLSSSSTSTKSAKSGSEASASASKD 317
           G  +G   P+    EE EE  ++ R  +    D+E+L        +              
Sbjct: 5   GGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMT-------------- 50

Query: 318 ALQAMILSLPRYHCENPASCKSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIP 377
                         +N  S +    S  T R +   +G   FN++P KGIQFLI    + 
Sbjct: 51  ------------EIDNLTSVEE---SKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQ 95

Query: 378 DTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSSMELDEALRKFQA 437
            +P  VA FL + +GL++ +IG++LG  + +FN  VL   V+  +F+ + L +ALR+F  
Sbjct: 96  SSPEDVAQFLYKGEGLNKTVIGDYLGE-RDEFNIKVLQAFVELHEFADLNLVQALRQFLW 154

Query: 438 HIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKP 497
             R+ GEAQK++R++EAF+ RYC+CNP V   F + DT ++L+FAII+LNT +++ N++ 
Sbjct: 155 SFRLPGEAQKIDRMMEAFASRYCLCNPGV---FQSTDTCYVLSFAIIMLNTSLHNHNVRD 211

Query: 498 DRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELKSNED 541
             K   E FI   RG+++G D+P EL+  +YE I+ +  K  ED
Sbjct: 212 --KPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIPED 253


>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
          Length = 397

 Score =  156 bits (395), Expect = 6e-38
 Identities = 82/194 (42%), Positives = 126/194 (64%), Gaps = 6/194 (3%)

Query: 348 RKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKK 407
           R +   +G   FN++P KGIQFLI    + +T   +A FL + +GL++  IG++LG  + 
Sbjct: 62  RNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGE-RD 120

Query: 408 QFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVV 467
           +FN  VL   V+  +F+ + L +ALR+F    R+ GEAQK++R++EAF+QRYC CN  V 
Sbjct: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGV- 179

Query: 468 QQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGI 527
             F + DT ++L+FAII+LNT +++PN+K   K  +E FI   RG++DG D+P EL+  +
Sbjct: 180 --FQSTDTCYVLSFAIIMLNTSLHNPNVKD--KPTVERFIAMNRGINDGGDLPEELLRNL 235

Query: 528 YERIQQKELKSNED 541
           YE I+ +  K  ED
Sbjct: 236 YESIKNEPFKIPED 249


>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
          Length = 398

 Score =  156 bits (395), Expect = 6e-38
 Identities = 82/194 (42%), Positives = 126/194 (64%), Gaps = 6/194 (3%)

Query: 348 RKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKK 407
           R +   +G   FN++P KGIQFLI    + +T   +A FL + +GL++  IG++LG  + 
Sbjct: 62  RNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGE-RD 120

Query: 408 QFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVV 467
           +FN  VL   V+  +F+ + L +ALR+F    R+ GEAQK++R++EAF+QRYC CN  V 
Sbjct: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGV- 179

Query: 468 QQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGI 527
             F + DT ++L+FAII+LNT +++PN+K   K  +E FI   RG++DG D+P EL+  +
Sbjct: 180 --FQSTDTCYVLSFAIIMLNTSLHNPNVKD--KPTVERFIAMNRGINDGGDLPEELLRNL 235

Query: 528 YERIQQKELKSNED 541
           YE I+ +  K  ED
Sbjct: 236 YESIKNEPFKIPED 249


>gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange
           protein 1 [Homo sapiens]
          Length = 1849

 Score =  150 bits (379), Expect = 4e-36
 Identities = 87/222 (39%), Positives = 131/222 (59%), Gaps = 10/222 (4%)

Query: 348 RKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKK 407
           +K +   G++LFN  P +GIQ+L  +G +  TP  +A FL Q + L    +GEFLG++ K
Sbjct: 698 QKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDK 757

Query: 408 QFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVV 467
            FN++V+   VD+ DFS  +   ALR F    R+ GEAQK++RL+E F+ RY  CN +  
Sbjct: 758 -FNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECN-QGQ 815

Query: 468 QQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGI 527
             F + DT ++LA++II+L TD++SP +K   KM  E +I+  RG++D  D+P E +  I
Sbjct: 816 TLFASADTAYVLAYSIIMLTTDLHSPQVK--NKMTKEQYIKMNRGINDSKDLPEEYLSAI 873

Query: 528 YERIQQKELKSNE-DHVTYVTKVEKSIVGMKTVLSVPHRRLV 568
           Y  I  K++   E   +T  TK  K     + V S   RRL+
Sbjct: 874 YNEIAGKKISMKETKELTIPTKSSK-----QNVASEKQRRLL 910


>gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange
           factor 2 [Homo sapiens]
          Length = 1785

 Score =  149 bits (377), Expect = 7e-36
 Identities = 90/248 (36%), Positives = 141/248 (56%), Gaps = 11/248 (4%)

Query: 348 RKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKK 407
           +K +   G+ LFN  P +GIQFL  +G +  +   +A FL Q + L    +G+FLG+S +
Sbjct: 643 QKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSAR 702

Query: 408 QFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVV 467
            FN++V+   VD++DF   E   ALR F    R+ GEAQK++RL+E F+ RY  CN +  
Sbjct: 703 -FNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECN-QGQ 760

Query: 468 QQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGI 527
             F + DT ++LA++II+L TD++SP +K   KM  E +I+  RG++D  D+P E +  I
Sbjct: 761 TLFASADTAYVLAYSIIMLTTDLHSPQVK--NKMTKEQYIKMNRGINDSKDLPEEYLSSI 818

Query: 528 YERIQQKELKSNE-DHVTYVTKVEKSIVGMKTVLSVPHRRLVCCSRLFEVTDVNK-LQKQ 585
           YE I+ K++   E   +T  TK  K     + V S   RRL+    + ++    K L + 
Sbjct: 819 YEEIEGKKIAMKETKELTIATKSTK-----QNVASEKQRRLLYNLEMEQMAKTAKALMEA 873

Query: 586 AAHQREVF 593
            +H +  F
Sbjct: 874 VSHAKAPF 881


>gi|4758416 golgi-specific brefeldin A resistant guanine nucleotide
           exchange factor 1 [Homo sapiens]
          Length = 1859

 Score =  136 bits (343), Expect = 6e-32
 Identities = 94/285 (32%), Positives = 144/285 (50%), Gaps = 15/285 (5%)

Query: 268 TEEEEEEEETAEVGR--GAEAEAGDLEQLSSSSTSTKSAKSG-SEASASASKDALQAMIL 324
           T E    E TA  G+  G  ++   L          +  KSG S+   +    A +    
Sbjct: 619 TREASNTERTASDGKAVGMASDIPGLHLPGGGRLPPEHGKSGCSDLEEAVDSGADKKFAR 678

Query: 325 SLPRYHCENPASCKSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGF--IPDTPIG 382
             PR+ C  P   +   +     +K+L   G   FN  P KGIQFL  +G   IP     
Sbjct: 679 KPPRFSCLLPDPRELIEIKN---KKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNTE 735

Query: 383 VAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQ 442
           VA +L +   L ++MIGEF+ + K   N D+L+  V    F  + LDEALR +    R+ 
Sbjct: 736 VAQWLRENPRLDKKMIGEFVSDRK---NIDLLESFVSTFSFQGLRLDEALRLYLEAFRLP 792

Query: 443 GEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNI-KPDRKM 501
           GEA  ++RL+EAF++R+  CN      F N D  F LA+A+I+LNTD ++ N+ K +  M
Sbjct: 793 GEAPVIQRLLEAFTERWMNCNG---SPFANSDACFSLAYAVIMLNTDQHNHNVRKQNAPM 849

Query: 502 MLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELKSNEDHVTYV 546
            LE+F +NL+GV+ G D  ++++  +Y  I+ +E+   E+    V
Sbjct: 850 TLEEFRKNLKGVNGGKDFEQDILEDMYHAIKNEEIVMPEEQTGLV 894


>gi|7019505 cytohesin 4 [Homo sapiens]
          Length = 394

 Score =  135 bits (341), Expect = 1e-31
 Identities = 69/188 (36%), Positives = 118/188 (62%), Gaps = 6/188 (3%)

Query: 354 IGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDV 413
           IG   FN++P KGIQ+ I    +      +A FL + +GL++  IG +LG  +   N  V
Sbjct: 67  IGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGE-RDPINLQV 125

Query: 414 LDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNP 473
           L   VD  +F+++ L +ALR+F    R+ GEAQK++R++EAF+ RYC+CNP V   F + 
Sbjct: 126 LQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGV---FQST 182

Query: 474 DTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQ 533
           DT ++L+F+II+LNT +++PN++   +   E F+   RG+++G+D+P + +  +++ I+ 
Sbjct: 183 DTCYVLSFSIIMLNTSLHNPNVRD--RPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKS 240

Query: 534 KELKSNED 541
           +     ED
Sbjct: 241 EPFSIPED 248


>gi|48928044 F-box only protein 8 [Homo sapiens]
          Length = 319

 Score =  104 bits (259), Expect = 3e-22
 Identities = 60/175 (34%), Positives = 102/175 (58%), Gaps = 11/175 (6%)

Query: 359 FNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVV 418
           FN NPD+G+ + +S+G + D+P  +A F+   + L+ + +  +L        RDVLD +V
Sbjct: 146 FNANPDEGVNYFMSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDE-----RRDVLDDLV 200

Query: 419 DEMDFSSMELDEALRKFQAHIRVQGE-AQKVERLIEAFSQRYCMCNPEVVQQFH-NPDTI 476
              +F +  L  ALR+F  HI    E  + +E LI  FS R+C CNP+++++   +PD +
Sbjct: 201 TLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRELGLSPDAV 260

Query: 477 FILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERI 531
           ++L +++ILL+ D+ SP++K   KM   +FIRN R      +I  + V  +Y+ I
Sbjct: 261 YVLCYSLILLSIDLTSPHVK--NKMSKREFIRNTRRA--AQNISEDFVGHLYDNI 311


>gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]
          Length = 1024

 Score =  101 bits (251), Expect = 3e-21
 Identities = 96/313 (30%), Positives = 137/313 (43%), Gaps = 54/313 (17%)

Query: 233 EAPEAPAVGREDASAEDSCA----EAAASGAADGATAPKTEEEEEEEETAEVGRGAEAEA 288
           E P  P   R D  A    A    ++  S AADG    + EEEE E   A++  G E  +
Sbjct: 443 ELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQRGEEEEAEAR-AKLAPGREPPS 501

Query: 289 GDLEQLSSSSTSTKSAKSGSEASASASKDALQAMILSLPRYHCENPASC----KSPTLST 344
                 S  S    +A  GSE   S       + + S  R    +  +     K+   + 
Sbjct: 502 ---PCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLALGSTDTLSNGQKADLEAA 558

Query: 345 DTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGN 404
             L KRLYR+                   GF       VA  L +    S+ + GE+L  
Sbjct: 559 QRLAKRLYRLD------------------GF---RKADVARHLGKNNDFSKLVAGEYL-- 595

Query: 405 SKKQFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNP 464
             K F             F+ M LD+ALR F   + + GE Q+ ER++  FSQRY  CNP
Sbjct: 596 --KFFV------------FTGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNP 641

Query: 465 EVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELV 524
           E +    + D    L  A++LLNTD++  NI   ++M   DFI NL G++DG D PREL+
Sbjct: 642 EALS---SEDGAHTLTCALMLLNTDLHGHNI--GKRMTCGDFIGNLEGLNDGGDFPRELL 696

Query: 525 VGIYERIQQKELK 537
             +Y  I+ ++L+
Sbjct: 697 KALYSSIKNEKLQ 709


>gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6
           isoform b [Homo sapiens]
          Length = 513

 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 53/155 (34%), Positives = 90/155 (58%), Gaps = 6/155 (3%)

Query: 383 VAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQ 442
           +A  L Q     R  + + LG +  +F++ V +  +   DF+ M LD++LR F     + 
Sbjct: 54  LAKRLYQLDRFKRSDVAKHLGKNN-EFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLV 112

Query: 443 GEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMM 502
           GE Q+ ER++  FS RY  CNP+ +    + D +  L  AI+LLNTD++  NI   +KM 
Sbjct: 113 GETQERERVLIHFSNRYFYCNPDTIA---SQDGVHCLTCAIMLLNTDLHGHNI--GKKMT 167

Query: 503 LEDFIRNLRGVDDGADIPRELVVGIYERIQQKELK 537
            ++FI NL+GV++G D  ++L+  +Y  I+ ++L+
Sbjct: 168 CQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLE 202


>gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6
           isoform a [Homo sapiens]
          Length = 1047

 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 53/155 (34%), Positives = 90/155 (58%), Gaps = 6/155 (3%)

Query: 383 VAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQ 442
           +A  L Q     R  + + LG +  +F++ V +  +   DF+ M LD++LR F     + 
Sbjct: 588 LAKRLYQLDRFKRSDVAKHLGKNN-EFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLV 646

Query: 443 GEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMM 502
           GE Q+ ER++  FS RY  CNP+ +    + D +  L  AI+LLNTD++  NI   +KM 
Sbjct: 647 GETQERERVLIHFSNRYFYCNPDTIA---SQDGVHCLTCAIMLLNTDLHGHNI--GKKMT 701

Query: 503 LEDFIRNLRGVDDGADIPRELVVGIYERIQQKELK 537
            ++FI NL+GV++G D  ++L+  +Y  I+ ++L+
Sbjct: 702 CQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLE 736


>gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]
          Length = 771

 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 76/277 (27%), Positives = 121/277 (43%), Gaps = 61/277 (22%)

Query: 261 DGATAPKTEEEEEEEETAEVGRGAEAEAGDLEQLSSSSTSTKSAKSGSEASASASKDALQ 320
           DG   P  +E+++EE+T ++   A   +     L    + + S  S SE     S D L 
Sbjct: 250 DGPQGPGGDEDDDEEDTDKLLNSASDPS-----LKDGLSDSDSELSSSEGLEPGSADPLA 304

Query: 321 AMILSLPRYHCENPASCKSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTP 380
                           C+  + +   L +RLY +                   GF     
Sbjct: 305 N--------------GCQGVSEAAHRLARRLYHL------------------EGF----- 327

Query: 381 IGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSSMELDEALRKFQAHIR 440
                   QR  ++RQ+          +F+R V    +   DFS + LD ALR F     
Sbjct: 328 --------QRCDVARQL------GKNNEFSRLVAGEYLSFFDFSGLTLDGALRTFLKAFP 373

Query: 441 VQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRK 500
           + GE Q+ ER++  FS+RYC CNP+      + D I  L  A++LLNTD++  NI   +K
Sbjct: 374 LMGETQERERVLTHFSRRYCQCNPD---DSTSEDGIHTLTCALMLLNTDLHGHNI--GKK 428

Query: 501 MMLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELK 537
           M  + FI NL  ++DG D  ++L+  +Y  I+ ++L+
Sbjct: 429 MSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLE 465


>gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]
          Length = 1056

 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 51/155 (32%), Positives = 86/155 (55%), Gaps = 6/155 (3%)

Query: 383 VAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQ 442
           +A  L + +G  +  +  +L      F+R V +  +    F    LD ALR F   + + 
Sbjct: 591 LASRLYRLEGFRKSEVAAYL-QKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLS 649

Query: 443 GEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMM 502
           GE Q+ ER++  FS+R+  CNP +   F + D++  L  AI+LLNTD++  NI   + M 
Sbjct: 650 GETQERERILYQFSRRFHHCNPGI---FPSVDSVHTLTCAIMLLNTDLHGQNI--GKSMS 704

Query: 503 LEDFIRNLRGVDDGADIPRELVVGIYERIQQKELK 537
            ++FI NL G+ DG + P+EL+  +Y  I+ ++L+
Sbjct: 705 CQEFITNLNGLRDGGNFPKELLKALYWSIRSEKLE 739


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 48/221 (21%), Positives = 86/221 (38%), Gaps = 45/221 (20%)

Query: 143  PPGLEAEGRAPESAGPGPGDDAAETPG---LPPAHS---GTLMMAFRDVTVQIANQNISV 196
            PP   ++ R      P P     + P    LPPA       +  AF D +  +  Q   V
Sbjct: 2410 PPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPV 2469

Query: 197  SSSTALS----------VANCLGAQTVQAPAEPAAGKAEQGETSGREAPEA-----PAVG 241
            + S +LS            +  G  +V AP  P +   E   ++G + P A     PA  
Sbjct: 2470 AGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKE 2529

Query: 242  REDASAEDSCAEAAASGAADGATAPKTEEEEEEEETAEV--------------------- 280
            R  +S+  S + +++S ++  +++  +     + E + +                     
Sbjct: 2530 RRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEA 2589

Query: 281  ---GRGAEAEAGDLEQLSSSSTSTKSAKSGSEASASASKDA 318
               GR  E      ++ SSSS+S+ S+ S S +S+S+S  +
Sbjct: 2590 VREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSS 2630


>gi|27894378 chloride intracellular channel 6 [Homo sapiens]
          Length = 686

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 54/192 (28%), Positives = 79/192 (41%), Gaps = 25/192 (13%)

Query: 140 AAGPPG--LEAEGRAPESAGPG-PGDDAAETPGLPPAHS-------GTLMMA------FR 183
           A GP G  ++AEGR  +S   G P  D  E  G+P   S       G  M A       R
Sbjct: 232 AEGPAGDSVDAEGRVGDSVEAGDPAGDGVEA-GVPAGDSVEAEGPAGDSMDAEGPAGRAR 290

Query: 184 DVTVQIANQNISVSSSTALSVANCLGAQTVQAPAEPAAGKAEQGETSGREAPEAPAVGRE 243
            V+ +         S  A ++    G    ++P E A   AE+ E  G +       G E
Sbjct: 291 RVSGEPQQSGDGSLSPQAEAIEVAAGESAGRSPGELAWDAAEEAEVPGVK-------GSE 343

Query: 244 DASAEDSCAEAAASGAADGATAPKTEEEEEEEETAEVGRGAEAEAGDLEQLSSSSTSTKS 303
           +A+  D+ A+A      DG      E+EE  E + E  R  EA  G+ E+   SS   ++
Sbjct: 344 EAAPGDARADAGEDRVGDGPQQEPGEDEERRERSPEGPREEEAAGGE-EESPDSSPHGEA 402

Query: 304 AKSGSEASASAS 315
           ++  +E  A  S
Sbjct: 403 SRGAAEPEAQLS 414



 Score = 38.1 bits (87), Expect = 0.031
 Identities = 41/154 (26%), Positives = 56/154 (36%), Gaps = 27/154 (17%)

Query: 148 AEGRAPESAGPGPGDDA------AETPGLPPAHSGTLMMAFRDVTVQIANQNISVSSSTA 201
           AE   PE   PGP          AE PG P A  G       +      ++    +   A
Sbjct: 2   AEAAEPEGVAPGPQGPPEVPAPLAERPGEPGAAGG-------EAEGPEGSEGAEEAPRGA 54

Query: 202 LSVANCLGAQTVQAPAEPAAG--------KAEQGETSGREAPEAPAVGREDASAEDSCAE 253
            +V    G    + P   A G        +AE+G   G E P+    G E+ S       
Sbjct: 55  AAVKEAGGGGPDRGPEAEARGTRGAHGETEAEEGAPEGAEVPQ----GGEETSGAQQVEG 110

Query: 254 AAASGAADGATAPKTEEEEEEEETAEVGRGAEAE 287
           A+    A G   P+ E + E E++A   R  EAE
Sbjct: 111 ASPGRGAQG--EPRGEAQREPEDSAAPERQEEAE 142



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 33/85 (38%), Positives = 39/85 (45%), Gaps = 7/85 (8%)

Query: 210 AQTVQAPAEPAA--GKAE--QGETSGREAPE-APAVGREDASAEDSCAEAAASGAADGAT 264
           A   + P EP A  G+AE  +G     EAP  A AV        D   EA A G   GA 
Sbjct: 22  APLAERPGEPGAAGGEAEGPEGSEGAEEAPRGAAAVKEAGGGGPDRGPEAEARGTR-GAH 80

Query: 265 APKTEEEEEEEETAEVGRGAEAEAG 289
             +TE EE   E AEV +G E  +G
Sbjct: 81  G-ETEAEEGAPEGAEVPQGGEETSG 104



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 45/161 (27%), Positives = 57/161 (35%), Gaps = 28/161 (17%)

Query: 140 AAGPPGLEAEGRAPESA---------GPGPGDDAAETPGLPPAHSGTLMMAFRDVTVQIA 190
           A GP G E    AP  A         GP  G +A E  G   AH  T            A
Sbjct: 38  AEGPEGSEGAEEAPRGAAAVKEAGGGGPDRGPEA-EARGTRGAHGETE-----------A 85

Query: 191 NQNISVSSSTALSVANCLGAQTVQAPAEPAAGKAEQGETSG---REAPEAPAVGR-EDAS 246
            +     +          GAQ V+  A P  G+  QGE  G   RE  ++ A  R E+A 
Sbjct: 86  EEGAPEGAEVPQGGEETSGAQQVEG-ASP--GRGAQGEPRGEAQREPEDSAAPERQEEAE 142

Query: 247 AEDSCAEAAASGAADGATAPKTEEEEEEEETAEVGRGAEAE 287
                 E +ASG A  +   +    +  E     G   EAE
Sbjct: 143 QRPEVPEGSASGEAGDSVDAEGPLGDNIEAEGPAGDSVEAE 183


>gi|167234429 zinc finger and BTB domain containing 17 [Homo
           sapiens]
          Length = 803

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 64/231 (27%), Positives = 90/231 (38%), Gaps = 23/231 (9%)

Query: 89  AGTLTELEDSFTEQVQSLAKSIDDALSTWSLKTMCSLRESGAYQLHQALQAAAGPPGLEA 148
           AG    LE  +T ++    +++DD L+  +   M  +    A    ++L   A  PG  A
Sbjct: 68  AGLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIIT--ACHALKSLAEPATSPGGNA 125

Query: 149 EGRAPESAGPGPGDDAAETPGLPPAHSGTLMMAFRDVTVQIANQNISVSSSTALSVANCL 208
           E  A E      GD  A+   +  +    L  A R   +  +          A S A+  
Sbjct: 126 EALATEG-----GDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLKEERGGQAQSAAS-- 178

Query: 209 GAQTVQ---APAEPAAGKAEQGETSGREAPEAPAVGREDASAEDSCAEAAASGAADGATA 265
           GA+  +   AP EP   + +   TSG  A EA     E A +E S  E     A  G   
Sbjct: 179 GAEQTEKADAPREPPPVELKPDPTSGMAAAEA-----EAALSESSEQEMEVEPARKGEEE 233

Query: 266 PKTEEEEEEE-----ETAEVGRGAEAEAGDLEQLSSSSTSTKSAKS-GSEA 310
            K +EE+EEE     E  E G   E      E  +  S  T S +  GSEA
Sbjct: 234 QKEQEEQEEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDSGQELGSEA 284


>gi|153070260 myristoylated alanine-rich protein kinase C substrate
           [Homo sapiens]
          Length = 332

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 62/206 (30%), Positives = 80/206 (38%), Gaps = 27/206 (13%)

Query: 124 SLRESGAYQLHQALQAAAGPPGLEA--EGRAPESAGP----GPGDDAAETPGLPPAHSGT 177
           S  E G      A +A A P   EA  EG A E   P    G    AA +   P A  G 
Sbjct: 83  SAAEKGEPAAAAAPEAGASPVEKEAPAEGEAAEPGSPTAAEGEAASAASSTSSPKAEDGA 142

Query: 178 LMMAFRDVTVQIANQNISVSSSTALSVANCLGAQTVQAPAEPAAGKAEQGETSGREAPEA 237
                 + T +   +  S   S  LS  +                K E GE    EAP A
Sbjct: 143 TPSPSNE-TPKKKKKRFSFKKSFKLSGFSF------------KKNKKEAGEGGEAEAPAA 189

Query: 238 PAVGREDASAEDSCAEAAASGAADG--ATAPKTEEEEEEEETAEVGRGAEA---EAGDLE 292
              G +D +A  + A AA +GAA G  A AP  EE    EE A  G   EA   EA    
Sbjct: 190 E--GGKDEAAGGAAAAAAEAGAASGEQAAAP-GEEAAAGEEGAAGGDPQEAKPQEAAVAP 246

Query: 293 QLSSSSTSTKSAKSGSEASASASKDA 318
           +   +S  TK+A+  S+     +++A
Sbjct: 247 EKPPASDETKAAEEPSKVEEKKAEEA 272



 Score = 37.4 bits (85), Expect = 0.052
 Identities = 47/185 (25%), Positives = 70/185 (37%), Gaps = 35/185 (18%)

Query: 161 GDDAAETPGLPPAHSGTLMMAFRDVTVQIANQNISVSSSTALSVANCLGAQTVQA----P 216
           G+ AAE PG     S       ++      N ++ V+   + + A     + +QA    P
Sbjct: 12  GEAAAERPGEAAVASSPSKANGQE------NGHVKVNGDASPAAAESGAKEELQANGSAP 65

Query: 217 A----EPAAG--------KAEQGETSGREAPEA---------PAVGREDASAEDSCAEAA 255
           A    EPAA          AE+GE +   APEA         PA G        + AE  
Sbjct: 66  AADKEEPAAAGSGAASPSAAEKGEPAAAAAPEAGASPVEKEAPAEGEAAEPGSPTAAEGE 125

Query: 256 ASGAADGATAPKTEEEEEEEETAEVGRGAEAEAGDLEQLSSSSTS----TKSAKSGSEAS 311
           A+ AA   ++PK E+      + E  +  +      +    S  S     K A  G EA 
Sbjct: 126 AASAASSTSSPKAEDGATPSPSNETPKKKKKRFSFKKSFKLSGFSFKKNKKEAGEGGEAE 185

Query: 312 ASASK 316
           A A++
Sbjct: 186 APAAE 190



 Score = 35.0 bits (79), Expect = 0.26
 Identities = 29/116 (25%), Positives = 54/116 (46%), Gaps = 4/116 (3%)

Query: 208 LGAQTVQAPAEPAAGKAEQGETSGREAPEAPAVGREDASAE---DSCAEAAASGAADGAT 264
           +GAQ  +  A+  A     GE +   +P + A G+E+   +   D+   AA SGA +   
Sbjct: 1   MGAQFSKTAAKGEAAAERPGEAAVASSP-SKANGQENGHVKVNGDASPAAAESGAKEELQ 59

Query: 265 APKTEEEEEEEETAEVGRGAEAEAGDLEQLSSSSTSTKSAKSGSEASASASKDALQ 320
           A  +    ++EE A  G GA + +   +   +++ + ++  S  E  A A  +A +
Sbjct: 60  ANGSAPAADKEEPAAAGSGAASPSAAEKGEPAAAAAPEAGASPVEKEAPAEGEAAE 115



 Score = 34.7 bits (78), Expect = 0.34
 Identities = 42/148 (28%), Positives = 59/148 (39%), Gaps = 19/148 (12%)

Query: 195 SVSSSTALSVANCLGAQTVQAPAEPAAGKAEQGETSGREAP-EAPAVGREDASAEDSCA- 252
           +V+SS + +     G   V   A PAA  AE G     +A   APA  +E+ +A  S A 
Sbjct: 23  AVASSPSKANGQENGHVKVNGDASPAA--AESGAKEELQANGSAPAADKEEPAAAGSGAA 80

Query: 253 --EAAASGAADGATAPKTEEEEEEEETAEVGRGAEAEAGDLEQLSSSSTSTKSAKSGSEA 310
              AA  G    A AP+      E+E    G  AE               + +A  G  A
Sbjct: 81  SPSAAEKGEPAAAAAPEAGASPVEKEAPAEGEAAEP-------------GSPTAAEGEAA 127

Query: 311 SASASKDALQAMILSLPRYHCENPASCK 338
           SA++S  + +A   + P    E P   K
Sbjct: 128 SAASSTSSPKAEDGATPSPSNETPKKKK 155



 Score = 33.1 bits (74), Expect = 0.98
 Identities = 43/165 (26%), Positives = 55/165 (33%), Gaps = 44/165 (26%)

Query: 127 ESGAYQLHQAL----QAAAGPPGLEAEGRAPESAGPGPGDDAAETPGLPPAHSGTLMMAF 182
           E+GA    QA     +AAAG  G  A G  P+ A P    +AA  P  PPA   T     
Sbjct: 206 EAGAASGEQAAAPGEEAAAGEEG--AAGGDPQEAKP---QEAAVAPEKPPASDET----- 255

Query: 183 RDVTVQIANQNISVSSSTALSVANCLGAQTVQAPAEPAAGKAEQGETSGR--EAPEAPAV 240
                                       +  + P++    KAE+   S    EAP A   
Sbjct: 256 ----------------------------KAAEEPSKVEEKKAEEAGASAAACEAPSAAGP 287

Query: 241 GREDASAEDSCAEAAASGAADGATAPKTEEEEEEEETAEVGRGAE 285
           G           E AA+ A+    AP  E + E    A     AE
Sbjct: 288 GAPPEQEAAPAEEPAAAAASSACAAPSQEAQPECSPEAPPAEAAE 332



 Score = 30.4 bits (67), Expect = 6.4
 Identities = 38/156 (24%), Positives = 55/156 (35%), Gaps = 4/156 (2%)

Query: 154 ESAGPGPGDDAAETPGLPPAHSGTLMMAFRDVTVQIANQNISVSSSTALSVANCLGAQTV 213
           + AG G   +A    G     +G    A  +       Q  +     A       G    
Sbjct: 176 KEAGEGGEAEAPAAEGGKDEAAGGAAAAAAEAGAASGEQAAAPGEEAAAGEEGAAGGDPQ 235

Query: 214 QAPAEPAAGKAEQGETSGR-EAPEAPAVGREDASAEDSCAEAAASGA--ADGATAPKTEE 270
           +A  + AA   E+   S   +A E P+   E+  AE++ A AAA  A  A G  AP  +E
Sbjct: 236 EAKPQEAAVAPEKPPASDETKAAEEPSKV-EEKKAEEAGASAAACEAPSAAGPGAPPEQE 294

Query: 271 EEEEEETAEVGRGAEAEAGDLEQLSSSSTSTKSAKS 306
               EE A     +   A   E     S     A++
Sbjct: 295 AAPAEEPAAAAASSACAAPSQEAQPECSPEAPPAEA 330


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 48/176 (27%), Positives = 66/176 (37%), Gaps = 16/176 (9%)

Query: 138  QAAAGPPGLEAEG-RAPESAGPGP---GDDAAETPGLPPAHSGTLMMAFRDVTVQIANQN 193
            Q A G    E+EG  APE+ G      G +A ET G     S  +     +   Q  ++ 
Sbjct: 2088 QEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEG 2147

Query: 194  ISVSSSTALSVANCLGAQTVQAPAEPAAGKAEQGETSGREAPEAPAVGR-EDASAEDSCA 252
            +    +   +     G +  +A  E       Q E  G EAPEA    + E    E   A
Sbjct: 2148 VEAQDAEGEAQPESEGIEAQEAEEEA------QPELEGVEAPEAEGEAQPESEGIEAPEA 2201

Query: 253  EAAASGAADGATAPKTEEEEEEEETAEVGRGAEAEAGDLEQLSSSSTSTKSAKSGS 308
            E  A    +G  AP+ EEE + E       G E    + E    S   T+  K GS
Sbjct: 2202 EGEAQPELEGVEAPEAEEEAQPEP-----EGVETPEAEGEAQPESEGETQGEKKGS 2252



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 47/161 (29%), Positives = 68/161 (42%), Gaps = 18/161 (11%)

Query: 140  AAGPPGLEAEGRA-PESAG---PGPGDDAAETPGLPPAHSGTLMMAFRDVTVQIANQNIS 195
            A G    EAEG A PES G   P    DA E  G     S  +     +   Q  ++++ 
Sbjct: 1832 AEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVE 1891

Query: 196  VSSSTALSVANCLGAQTVQAP--AEPAAGKAEQGETSGREAPEAPAVGREDASAEDSCAE 253
               +         GA+  +A   A+P     E  ET G + PE+   G E   AE++  E
Sbjct: 1892 TPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESE--GAEAQEAEEAAQE 1949

Query: 254  AAASGAADGATAPKTEEEEEEEETAEVGRGAEAEAGDLEQL 294
                  A+G T P++E  E +E   E    A+ E+ D+E L
Sbjct: 1950 ------AEGQTQPESEVIESQEAEEE----AQPESEDVEAL 1980



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 34/116 (29%), Positives = 52/116 (44%), Gaps = 6/116 (5%)

Query: 209  GAQTVQAPAEPAAGKAEQGETSGREAPEAPAVGREDASAEDSCAEAAASGAADGATAPKT 268
            GA+ ++AP   A G+A Q E+ G EAPEA    +E        +E   +  A+G   P++
Sbjct: 1831 GAEGIEAPE--AEGEA-QPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPES 1887

Query: 269  EEEEEEEETAEV---GRGAEAEAGDLEQLSSSSTSTKSAKSGSEASASASKDALQA 321
            E+ E  E   EV     GAEA   + E    + +       G +   S   +A +A
Sbjct: 1888 EDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEA 1943



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 40/148 (27%), Positives = 56/148 (37%), Gaps = 7/148 (4%)

Query: 147  EAEGRA-PESAG-----PGPGDDAAETPGLPPAHSGTLMMAFRDVTVQIANQNISVSSST 200
            EAE  A PES G        G++A E  G      G        V    A +    +   
Sbjct: 2011 EAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGE 2070

Query: 201  ALSVANCLGAQTVQAPAEPAAGKAEQGETSGREAPEAPAVGREDASAEDSCAEAAASGAA 260
                      ++    A+ A G+A Q E+ G EAPEA    ++    E    E  A   +
Sbjct: 2071 VQEAEGEAHPESEDVDAQEAEGEA-QPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPES 2129

Query: 261  DGATAPKTEEEEEEEETAEVGRGAEAEA 288
            +G  AP+ E E + E      + AE EA
Sbjct: 2130 EGIEAPEAEGEAQPESEGVEAQDAEGEA 2157



 Score = 37.4 bits (85), Expect = 0.052
 Identities = 33/139 (23%), Positives = 55/139 (39%), Gaps = 10/139 (7%)

Query: 210  AQTVQAPAEPAAGKAEQGETSGREAPEAPAVGREDAS---------AEDSCAEAAASGAA 260
            AQ  +  A+P +   E  E  G   PE+  V   +A          AE   AE  A    
Sbjct: 1860 AQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPET 1919

Query: 261  DGATAPKTEEEEEEEETAEVGRGAEAEAGDLEQLSSSSTSTKSAKSGSEASASASKDALQ 320
            +   A +TE E+E E      + AE  A + E  +   +    ++   E +   S+D ++
Sbjct: 1920 ESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESED-VE 1978

Query: 321  AMILSLPRYHCENPASCKS 339
            A+ + +     E  A  +S
Sbjct: 1979 ALEVEVETQEAEGEAQPES 1997



 Score = 37.4 bits (85), Expect = 0.052
 Identities = 31/113 (27%), Positives = 47/113 (41%), Gaps = 4/113 (3%)

Query: 210  AQTVQAPAEPAAGKAEQGETSGREAPEAPAVGREDASAEDSCAEAAASGAADGATA-PKT 268
            AQ      E    + E  E  G   PE+  V   +A  E   AE  A   +DG  A PK+
Sbjct: 1970 AQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKS 2029

Query: 269  EEEEEEE---ETAEVGRGAEAEAGDLEQLSSSSTSTKSAKSGSEASASASKDA 318
            E EE +E   ET +    A+ E+  +E   +   + ++     EA   A  ++
Sbjct: 2030 EGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPES 2082



 Score = 34.7 bits (78), Expect = 0.34
 Identities = 75/314 (23%), Positives = 113/314 (35%), Gaps = 46/314 (14%)

Query: 33   EKIRNSLLESRLPRRISLRKVRSPTAESLAAEKALMEGYGLVGLPLVRSPSLPPTFAGTL 92
            E +   LL     RR  LR +R+ +A S   E+ L  G G +   L   P+L       L
Sbjct: 1593 EALTGELLLQTQQRRHRLRGLRNLSAFS---ERTL--GLGPLSFTLEDEPALSTALGSQL 1647

Query: 93   TELEDSFTEQVQSLAKSIDDALSTWSLK-TMCSLRE--SGAYQLHQALQ----------A 139
             E  +   E+       +   +S  S K TM + R     A+ L Q LQ          A
Sbjct: 1648 GEEAEG--EEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEA 1705

Query: 140  AAGPPGLE----AEGRAPESAGPGPGDDAAETPGLPPAHSGT------------LMMAFR 183
            A   PG         R  + A  G G   ++ PG+     G             L  A  
Sbjct: 1706 AEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEG 1765

Query: 184  DVTVQIANQNISVSSSTALSVANCLGAQTVQAPAEPAAGKAEQGETSGREAPEAPAVGRE 243
            D   Q        S ++A       G++  +A  E   G +E+GET G+ +     +  E
Sbjct: 1766 DAMAQEREGKTHNSETSA-------GSELGEAEQE-GEGISERGETGGQGSGHEDNLQGE 1817

Query: 244  DASAEDSCAEAAASGAADGATAPKTEEEEEEEETAEVGRGAEAEAGDLEQLSSSSTSTKS 303
             A+  D   +   S  A+G  AP+ E E + E        AE +A + E  +   +    
Sbjct: 1818 AAAGGDQ--DPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVE 1875

Query: 304  AKSGSEASASASKD 317
            A      +   S+D
Sbjct: 1876 APEAEGEAQPESED 1889



 Score = 34.7 bits (78), Expect = 0.34
 Identities = 44/187 (23%), Positives = 71/187 (37%), Gaps = 7/187 (3%)

Query: 130  AYQLHQALQAAAGPPGLEAE----GRAPESAGPGPGD-DAAETPGLPPAHSGTLMMAFRD 184
            A +  +A Q A G    E+E      A E A P   D +A E         G       D
Sbjct: 1940 AQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESED 1999

Query: 185  VTVQIANQNISVSSSTALSVANCLGAQTVQAPAEPAAGKAEQGETSGREAPEAPAVGRED 244
            V    A   +  +   A   ++ + AQ      E    + E  +T G   PE+  V   +
Sbjct: 2000 VEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPE 2059

Query: 245  ASAEDSCAEAAASGAADGATAPKTEEEEEEEETAEVGRGAE-AEAGDLEQLSSSSTSTKS 303
            A  E   AE      A+G   P++E+ + +E   E    +E  EA + E  +  +   ++
Sbjct: 2060 AEEEAQEAEGEVQ-EAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEA 2118

Query: 304  AKSGSEA 310
             ++  EA
Sbjct: 2119 PETEGEA 2125



 Score = 34.7 bits (78), Expect = 0.34
 Identities = 30/121 (24%), Positives = 47/121 (38%), Gaps = 9/121 (7%)

Query: 210  AQTVQAPAEPAAGKAEQGETSGREAPEAPAVGREDASAEDSCAEAAASGAADGATAPKTE 269
            AQ  +   +P +   E  E      PE+  V   +   E   AE  A   ++   AP+ E
Sbjct: 1947 AQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAE 2006

Query: 270  EE--EEEEETAEVGRGAEA-------EAGDLEQLSSSSTSTKSAKSGSEASASASKDALQ 320
             E  E EEE      G EA       EA ++E  +  +      +S    +  A ++A +
Sbjct: 2007 GEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQE 2066

Query: 321  A 321
            A
Sbjct: 2067 A 2067


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 42.7 bits (99), Expect = 0.001
 Identities = 40/140 (28%), Positives = 67/140 (47%), Gaps = 14/140 (10%)

Query: 211 QTVQAPAEPAAGKAEQGETSGREAPEAPAVGR----EDAS--AEDSCAEAAASGAADGAT 264
           +T   PAE AA   ++ ++  +E  ++PA  +    E+A   AE    E A S A + A 
Sbjct: 500 ETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAK 559

Query: 265 AP---KTEEEEEEEETAEVGRGAEAEAGDLEQLSSSSTSTKSAKSGSEASASASKDALQA 321
           +P   K+ E+EE +  AEV    +A++   E+  S +     AKS  +A +   ++A   
Sbjct: 560 SPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPA----EAKSPEKAKSPVKEEAKSP 615

Query: 322 MILSLP-RYHCENPASCKSP 340
                P +   ++PA  KSP
Sbjct: 616 AEAKSPVKEEAKSPAEVKSP 635



 Score = 37.7 bits (86), Expect = 0.040
 Identities = 65/323 (20%), Positives = 122/323 (37%), Gaps = 25/323 (7%)

Query: 34  KIRNSLLE--SRLPRRISLRKVRSPTAESLAAEKALMEG----YGLVGLPLVRSPSLPPT 87
           ++RN+  E  ++L     L  V+      +AA + L+EG     G   +P      LP  
Sbjct: 370 ELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPK- 428

Query: 88  FAGTLTELEDSFTEQVQSLAKSIDDALSTWSLKTMCSLRESGAYQLHQALQAAAGPPGLE 147
                T ++    E+++ + KS          +T+    ++   Q+ + +         E
Sbjct: 429 IPSVSTHIKVKSEEKIKVVEKS--------EKETVIVEEQTEETQVTEEVTEEEEKEAKE 480

Query: 148 AEGRAPESAGPGPGDDAAETPGLPPAHSGTLMMAFRDVTVQIANQNISVSSST----ALS 203
            EG+  E       +   E    PPA             V+   ++ + + S     A S
Sbjct: 481 EEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKS 540

Query: 204 VANCLGAQTVQAPAEPAAGKAEQGETSGREAPEAPAVGREDASAEDSCAEAAASGA-ADG 262
            A     +  ++PA+  A    + ++  +E  ++PA  +    A+    E A S A A  
Sbjct: 541 PAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKS 600

Query: 263 ATAPKTEEEEEEEETAEVGRGAEAEAGDLEQLSS----SSTSTKSAKSGSEASASASKDA 318
               K+  +EE +  AE     + EA    ++ S     S + + AKS  +A +   ++A
Sbjct: 601 PEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEA 660

Query: 319 LQAMILSLP-RYHCENPASCKSP 340
                   P +   ++P   KSP
Sbjct: 661 KSPEKAKSPVKAEAKSPEKAKSP 683


>gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo
           sapiens]
          Length = 2462

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 74/324 (22%), Positives = 116/324 (35%), Gaps = 38/324 (11%)

Query: 10  LVSRRAACTIQTAFRQYQLSKNFEKI-RNSLLESRLPRRISLRKVRSPTAESLAAEKALM 68
           +V  +     +  +  Y+  +N ++I +   L+    R    +K ++P A   A+E+A  
Sbjct: 640 MVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAA---ASEEAAF 696

Query: 69  EGYGLVGLPLVRSPSLPPTFAGTLTELEDSFTEQVQSLAKSIDDALSTWSLKTMCSLRES 128
                   P+V    +    A  ++  E+   E+ ++   +  D  S  S  T  +    
Sbjct: 697 P-------PVVEDEEME---ASGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTG 746

Query: 129 GAYQLHQALQAAAGPPG---LEAEGRAPESAGPGPGDDAAETPGLPPAHSGTLMMAFRDV 185
                  A   A GPP           P    P P  +A   P  PPA            
Sbjct: 747 QNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPP---- 802

Query: 186 TVQIANQNISVSSSTALSVANCLGAQTVQAPAEPAA---GKAEQGETSG--REAPEAPAV 240
              +  +     ++ A  V    G +     AE  A   GKAE+   S    EA E PA 
Sbjct: 803 -PVVPKEEKEEETAAAPPVEE--GEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAK 859

Query: 241 GREDASAEDSCAEAA--------ASGAADGATAPKTEEEEEEEETAEVGRGAEAEAGDLE 292
           G+ DA A ++ AE A         SG A  A +    ++ +   T       EAE GD  
Sbjct: 860 GK-DAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKN 918

Query: 293 QLSSSSTSTKSAKSGSEASASASK 316
           +L S   S  +      A+AS  K
Sbjct: 919 RLLSPRPSLLTPTGDPRANASPQK 942


>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
          Length = 4374

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 75/327 (22%), Positives = 127/327 (38%), Gaps = 33/327 (10%)

Query: 24   RQYQLSKNFEKIRNSLLESRLPRRISLRKVRSPTAESLAAEKALMEGYGLVGLPLVRSPS 83
            R+ QL++   KI +   E +  R  S +   S + +S   E+ L +G  +         S
Sbjct: 2693 RRKQLAEEETKITDKGKEDKENRDQSAQCTASKSNDS--TEQNLSDGTPM-------PDS 2743

Query: 84   LPPTFAGTLTELEDSFTEQVQSLAKSIDDALSTWSLKTMCSLRESGAYQLHQALQAAAGP 143
             P T + T     D+ T + +    ++  +    +L T  +L E     + Q LQ+ AG 
Sbjct: 2744 YPTTPSST-----DAATSESKETLGTLQSSQQQPTLPTPPALGE-----VPQELQSPAGE 2793

Query: 144  PGLEAE---GRAPESAGPGPGDDAAETPG--LPPAHSGTLMMAFR----DVTVQIANQNI 194
             G   +      PE  GP      AET    L PA + T +   R    D    +++Q +
Sbjct: 2794 GGSSTQLLMPVEPEELGPTRPSGEAETTQMELSPAPTITSLSPERAEDSDALTAVSSQ-L 2852

Query: 195  SVSSSTALSVANCLGAQTVQAPAEPAAGKAEQGETSGREAPEAPAVGREDASAEDSCAEA 254
              S     S+A+C   + V   +  AAG +EQ         +AP    E     D   E+
Sbjct: 2853 EGSPMDTSSLASCTLEEAVGDTS--AAGSSEQPRAGSSTPGDAPPAVAEVQGRSDGSGES 2910

Query: 255  AASGAADGATAPKTEEEEEEEETAEVGRGAEAEAGDLEQLSSSSTSTKSAKSGSEASASA 314
            A     + ++ P + E     ++A    GA++     E L S+S+  +   +G       
Sbjct: 2911 AQ--PPEDSSPPASSESSSTRDSAVAISGADSRGILEEPLPSTSSEEEDPLAGISLPEGV 2968

Query: 315  SKDALQAMILSLPRYHCENPASCKSPT 341
                L A+   + R   +N    + PT
Sbjct: 2969 DPSFLAALPDDIRREVLQNQLGIRPPT 2995


>gi|73476377 LBXCOR1 homolog [Homo sapiens]
          Length = 921

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 55/223 (24%), Positives = 81/223 (36%), Gaps = 41/223 (18%)

Query: 104 QSLAKSIDDALSTWSLKTMCSLRESGAYQLHQALQAAAGPPGLEAEGRAPESAGPGP--- 160
           QS AK++  A++  +     +        L  A  A     GL AE R P +   GP   
Sbjct: 463 QSQAKAVAAAVAAAAAAAAAAAGSGAPEPLDGAEPAKES--GLGAEERCPSALSRGPLDE 520

Query: 161 -GDDAAETPGL--------PPAHSGTLMMAFRDVTVQIANQNISVSSSTALSVANCLGAQ 211
            G D A  P L        PPA  G+ + AFR V                 S+A   G+ 
Sbjct: 521 DGTDEALPPPLAPLPPPPPPPARKGSYVSAFRPVV------------KDTESIAKLYGSA 568

Query: 212 TVQAPAEPAAGKAEQGETSGREAPEAPAVGREDASAEDSCAEAAASGAADGATAPKTE-- 269
                A PA G      + G  +P        D  +E S +  +AS   D A  P+ +  
Sbjct: 569 REAYGAGPARGPGPGAGSGGYVSP--------DFLSEGSSSYNSASPDVDTADEPEVDVE 620

Query: 270 -----EEEEEEETAEVGRGAEAEAGDLEQLSSSSTSTKSAKSG 307
                ++E+ +E  E    +     D EQ +   ++T S   G
Sbjct: 621 SNRFPDDEDAQEETEPSAPSAGGGPDGEQPTGPPSATSSGADG 663


>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
          Length = 2968

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 34/140 (24%), Positives = 66/140 (47%), Gaps = 11/140 (7%)

Query: 218  EPAAGKA--EQGETSGREAPEAPAVGREDA-SAEDSCAEAAASGAADGATAPKTEEEEEE 274
            EP  G    + G     +  +A   G E++ S+  S + +++S ++  ++  +TE EEE 
Sbjct: 2528 EPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEG 2587

Query: 275  EETAEVGRG--------AEAEAGDLEQLSSSSTSTKSAKSGSEASASASKDALQAMILSL 326
            ++  + G G        A + A      SSSS+S+ S+ S S +S+S+S  +  +   S 
Sbjct: 2588 DKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2647

Query: 327  PRYHCENPASCKSPTLSTDT 346
                  + +S  S + S+ +
Sbjct: 2648 SSSSSSSSSSSSSSSSSSSS 2667



 Score = 30.4 bits (67), Expect = 6.4
 Identities = 39/210 (18%), Positives = 80/210 (38%), Gaps = 12/210 (5%)

Query: 124  SLRESGAYQLHQALQAAAGPPGLEAEGRAPESAGPGPGDDAAETPGLPPAHSGTLMMAFR 183
            SL   G+Y           P     +G   +  GPG   + +  P  P         A +
Sbjct: 2497 SLLSLGSYPPAAGSSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPKSPDK-----AQAEQ 2551

Query: 184  DVTVQIANQNISVS-SSTALSVANCLGAQTVQAPAEPAAGKAEQGETSGREAPEAPA--- 239
            D   +  + + S S SS++ S ++  G++T         G    G T GR    A +   
Sbjct: 2552 DGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCG-TGGRNCSAASSRAA 2610

Query: 240  --VGREDASAEDSCAEAAASGAADGATAPKTEEEEEEEETAEVGRGAEAEAGDLEQLSSS 297
                   +S+  S + +++S ++  +++  +        ++     + + +      SSS
Sbjct: 2611 SPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2670

Query: 298  STSTKSAKSGSEASASASKDALQAMILSLP 327
            ST+ + +   S+  A+ +  A  +   +LP
Sbjct: 2671 STTDEDSSCSSDDEAAPAPTAGPSAQAALP 2700


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.130    0.365 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,544,692
Number of Sequences: 37866
Number of extensions: 1346516
Number of successful extensions: 13669
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 137
Number of HSP's successfully gapped in prelim test: 460
Number of HSP's that attempted gapping in prelim test: 11003
Number of HSP's gapped (non-prelim): 2159
length of query: 759
length of database: 18,247,518
effective HSP length: 110
effective length of query: 649
effective length of database: 14,082,258
effective search space: 9139385442
effective search space used: 9139385442
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.