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Search of human proteins with 70780359
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
(1881 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 3733 0.0
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 3669 0.0
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 3669 0.0
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 3644 0.0
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 3005 0.0
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 1758 0.0
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 1749 0.0
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 1743 0.0
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 1678 0.0
gi|32967599 ankyrin 3 isoform 2 [Homo sapiens] 775 0.0
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 332 2e-90
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 327 9e-89
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 315 2e-85
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 305 3e-82
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 297 7e-80
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 296 1e-79
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 294 6e-79
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 235 3e-61
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 228 6e-59
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 223 1e-57
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 223 1e-57
gi|34304381 inversin isoform a [Homo sapiens] 199 2e-50
gi|34304379 inversin isoform b [Homo sapiens] 199 2e-50
gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform... 197 6e-50
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 196 2e-49
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 191 4e-48
gi|116534990 ankyrin-like protein 1 [Homo sapiens] 187 6e-47
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 182 3e-45
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 182 3e-45
gi|215598566 ankyrin 1 isoform 10 [Homo sapiens] 172 3e-42
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 3733 bits (9681), Expect = 0.0
Identities = 1881/1881 (100%), Positives = 1881/1881 (100%)
Query: 1 MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM 60
MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM
Sbjct: 1 MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM 60
Query: 61 VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ
Sbjct: 61 VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
Query: 121 ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA 180
ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA
Sbjct: 121 ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA 180
Query: 181 ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 240
ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI
Sbjct: 181 ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 240
Query: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
Query: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
Query: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600
HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600
Query: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
Query: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL
Sbjct: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
Query: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780
LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI
Sbjct: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780
Query: 781 SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE 840
SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE
Sbjct: 781 SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE 840
Query: 841 KELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSD 900
KELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSD
Sbjct: 841 KELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSD 900
Query: 901 NISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLS 960
NISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLS
Sbjct: 901 NISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLS 960
Query: 961 TPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEH 1020
TPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEH
Sbjct: 961 TPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEH 1020
Query: 1021 RSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEG 1080
RSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEG
Sbjct: 1021 RSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEG 1080
Query: 1081 GSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRK 1140
GSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRK
Sbjct: 1081 GSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRK 1140
Query: 1141 FHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANEC 1200
FHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANEC
Sbjct: 1141 FHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANEC 1200
Query: 1201 ANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYC 1260
ANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYC
Sbjct: 1201 ANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYC 1260
Query: 1261 MTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRE 1320
MTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRE
Sbjct: 1261 MTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRE 1320
Query: 1321 NRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPT 1380
NRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPT
Sbjct: 1321 NRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPT 1380
Query: 1381 PLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENP 1440
PLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENP
Sbjct: 1381 PLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENP 1440
Query: 1441 NSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHT 1500
NSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHT
Sbjct: 1441 NSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHT 1500
Query: 1501 DRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTM 1560
DRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTM
Sbjct: 1501 DRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTM 1560
Query: 1561 LEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLEL 1620
LEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLEL
Sbjct: 1561 LEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLEL 1620
Query: 1621 VEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQ 1680
VEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQ
Sbjct: 1621 VEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQ 1680
Query: 1681 ARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTE 1740
ARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTE
Sbjct: 1681 ARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTE 1740
Query: 1741 GLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGN 1800
GLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGN
Sbjct: 1741 GLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGN 1800
Query: 1801 EFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPSE 1860
EFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPSE
Sbjct: 1801 EFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPSE 1860
Query: 1861 LEVDIDYFMKHSKDHTSTPNP 1881
LEVDIDYFMKHSKDHTSTPNP
Sbjct: 1861 LEVDIDYFMKHSKDHTSTPNP 1881
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 3669 bits (9515), Expect = 0.0
Identities = 1852/1862 (99%), Positives = 1854/1862 (99%)
Query: 1 MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM 60
MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM
Sbjct: 1 MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM 60
Query: 61 VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ
Sbjct: 61 VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
Query: 121 ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA 180
ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA
Sbjct: 121 ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA 180
Query: 181 ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 240
ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI
Sbjct: 181 ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 240
Query: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
Query: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
Query: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600
HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600
Query: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
Query: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL
Sbjct: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
Query: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780
LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI
Sbjct: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780
Query: 781 SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE 840
SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE
Sbjct: 781 SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE 840
Query: 841 KELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSD 900
KELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSD
Sbjct: 841 KELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSD 900
Query: 901 NISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLS 960
NISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLS
Sbjct: 901 NISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLS 960
Query: 961 TPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEH 1020
TPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEH
Sbjct: 961 TPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEH 1020
Query: 1021 RSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEG 1080
RSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEG
Sbjct: 1021 RSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEG 1080
Query: 1081 GSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRK 1140
GSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRK
Sbjct: 1081 GSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRK 1140
Query: 1141 FHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANEC 1200
FHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANEC
Sbjct: 1141 FHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANEC 1200
Query: 1201 ANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYC 1260
ANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYC
Sbjct: 1201 ANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYC 1260
Query: 1261 MTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRE 1320
MTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRE
Sbjct: 1261 MTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRE 1320
Query: 1321 NRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPT 1380
NRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPT
Sbjct: 1321 NRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPT 1380
Query: 1381 PLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENP 1440
PLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENP
Sbjct: 1381 PLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENP 1440
Query: 1441 NSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHT 1500
NSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHT
Sbjct: 1441 NSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHT 1500
Query: 1501 DRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTM 1560
DRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTM
Sbjct: 1501 DRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTM 1560
Query: 1561 LEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLEL 1620
LEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLEL
Sbjct: 1561 LEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLEL 1620
Query: 1621 VEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQ 1680
VEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQ
Sbjct: 1621 VEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQ 1680
Query: 1681 ARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTE 1740
ARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTE
Sbjct: 1681 ARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTE 1740
Query: 1741 GLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGN 1800
GLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGN
Sbjct: 1741 GLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGN 1800
Query: 1801 EFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPSE 1860
EFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEV + G P
Sbjct: 1801 EFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEVELRGSGLQPDL 1860
Query: 1861 LE 1862
+E
Sbjct: 1861 IE 1862
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 3669 bits (9514), Expect = 0.0
Identities = 1856/1881 (98%), Positives = 1856/1881 (98%), Gaps = 25/1881 (1%)
Query: 1 MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM 60
MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM
Sbjct: 1 MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM 60
Query: 61 VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ
Sbjct: 61 VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
Query: 121 ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA 180
ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA
Sbjct: 121 ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA 180
Query: 181 ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 240
ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI
Sbjct: 181 ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 240
Query: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
Query: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
Query: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600
HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600
Query: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
Query: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL
Sbjct: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
Query: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780
LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI
Sbjct: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780
Query: 781 SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE 840
SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE
Sbjct: 781 SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE 840
Query: 841 KELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSD 900
KELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSD
Sbjct: 841 KELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSD 900
Query: 901 NISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLS 960
NISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLS
Sbjct: 901 NISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLS 960
Query: 961 TPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEH 1020
TPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEH
Sbjct: 961 TPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEH 1020
Query: 1021 RSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEG 1080
RSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEG
Sbjct: 1021 RSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEG 1080
Query: 1081 GSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRK 1140
GSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRK
Sbjct: 1081 GSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRK 1140
Query: 1141 FHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANEC 1200
FHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANEC
Sbjct: 1141 FHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANEC 1200
Query: 1201 ANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYC 1260
ANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYC
Sbjct: 1201 ANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYC 1260
Query: 1261 MTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRE 1320
MTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRE
Sbjct: 1261 MTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRE 1320
Query: 1321 NRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPT 1380
NRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPT
Sbjct: 1321 NRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPT 1380
Query: 1381 PLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENP 1440
PLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENP
Sbjct: 1381 PLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENP 1440
Query: 1441 NSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHT 1500
NSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHT
Sbjct: 1441 NSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHT 1500
Query: 1501 DRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTM 1560
DRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTM
Sbjct: 1501 DRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTM 1560
Query: 1561 LEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLEL 1620
LEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLEL
Sbjct: 1561 LEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLEL 1620
Query: 1621 VEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQ 1680
VEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQ
Sbjct: 1621 VEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQ 1680
Query: 1681 ARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTE 1740
ARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTE
Sbjct: 1681 ARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTE 1740
Query: 1741 GLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGN 1800
GLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGN
Sbjct: 1741 GLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGN 1800
Query: 1801 EFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPSE 1860
EFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEE
Sbjct: 1801 EFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEE------------ 1848
Query: 1861 LEVDIDYFMKHSKDHTSTPNP 1881
DHTSTPNP
Sbjct: 1849 -------------DHTSTPNP 1856
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 3644 bits (9449), Expect = 0.0
Identities = 1847/1882 (98%), Positives = 1849/1882 (98%), Gaps = 33/1882 (1%)
Query: 8 READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
++ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK
Sbjct: 41 KKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 100
Query: 68 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV
Sbjct: 101 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 160
Query: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187
KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR
Sbjct: 161 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 220
Query: 188 TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 247
TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS
Sbjct: 221 TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 280
Query: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307
RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS
Sbjct: 281 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 340
Query: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367
PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR
Sbjct: 341 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 400
Query: 368 ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427
ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG
Sbjct: 401 ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 460
Query: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487
ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK
Sbjct: 461 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 520
Query: 488 LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 547
LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG
Sbjct: 521 LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 580
Query: 548 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 607
KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH
Sbjct: 581 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 640
Query: 608 IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS 667
IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS
Sbjct: 641 IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS 700
Query: 668 GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727
GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV
Sbjct: 701 GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 760
Query: 728 NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK
Sbjct: 761 NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 820
Query: 788 VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEG--------EELISFKAERRDSRDVDE 839
VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEG EELISFKAERRDSRDVDE
Sbjct: 821 VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGTAHITIMGEELISFKAERRDSRDVDE 880
Query: 840 EKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETS 899
EKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETS
Sbjct: 881 EKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETS 940
Query: 900 DNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKL 959
DNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKL
Sbjct: 941 DNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKL 1000
Query: 960 STPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKE 1019
STPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKE
Sbjct: 1001 STPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKE 1060
Query: 1020 HRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPE 1079
HRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPE
Sbjct: 1061 HRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPE 1120
Query: 1080 GGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRR 1139
GGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRR
Sbjct: 1121 GGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRR 1180
Query: 1140 KFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANE 1199
KFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANE
Sbjct: 1181 KFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANE 1240
Query: 1200 CANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCY 1259
CANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCY
Sbjct: 1241 CANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCY 1300
Query: 1260 CMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFR 1319
CMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFR
Sbjct: 1301 CMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFR 1360
Query: 1320 ENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTP 1379
ENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTP
Sbjct: 1361 ENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTP 1420
Query: 1380 TPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVEN 1439
TPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVEN
Sbjct: 1421 TPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVEN 1480
Query: 1440 PNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRH 1499
PNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRH
Sbjct: 1481 PNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRH 1540
Query: 1500 TDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDT 1559
TDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDT
Sbjct: 1541 TDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDT 1600
Query: 1560 MLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLE 1619
MLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLE
Sbjct: 1601 MLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLE 1660
Query: 1620 LVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRG 1679
LVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRG
Sbjct: 1661 LVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRG 1720
Query: 1680 QARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMT 1739
QARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMT
Sbjct: 1721 QARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMT 1780
Query: 1740 EGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQG 1799
EGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQG
Sbjct: 1781 EGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQG 1840
Query: 1800 NEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPS 1859
NEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEE
Sbjct: 1841 NEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEE----------- 1889
Query: 1860 ELEVDIDYFMKHSKDHTSTPNP 1881
DHTSTPNP
Sbjct: 1890 --------------DHTSTPNP 1897
Score = 337 bits (865), Expect = 5e-92
Identities = 211/572 (36%), Positives = 309/572 (54%), Gaps = 41/572 (7%)
Query: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
SV F + T A+R GN+ L G I T ++ L LH A++ GHV++
Sbjct: 264 SVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEI 323
Query: 64 LLHKEIILETTTKKG---------------------------------NTALHIAALAGQ 90
LL ++ TK G T LH+AA G
Sbjct: 324 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGH 383
Query: 91 DEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAV 150
V + L++ GA N+++ GFTPL++A ++NH+ V++ LL+ GA+ + TE G TPL V
Sbjct: 384 HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV 443
Query: 151 ALQQGHENVVAHLINYG-----TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT 205
A GH +V +L+ G + KV P LH+AAR T A LLQN + +K
Sbjct: 444 ASFMGHLPIVKNLLQRGASPNVSNVKVETP-LHMAARAGHTEVAKYLLQNKAKVNAKAKD 502
Query: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
TPLH AA + N+ +LLL A+ N G TPLHIA+R G+V V LL++ A
Sbjct: 503 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 562
Query: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLL 325
TK TPLH AA+ G VR++E+LL+ A A KNGL+P+H+A ++LD V+LLL
Sbjct: 563 ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 622
Query: 326 QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR 385
+ TPLH+AA VA+ LL G N+ ++ G TPLH+A ++ H
Sbjct: 623 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 682
Query: 386 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 445
++ LLL A+ + +SGLTPLH+ + GH+P+ L++ G + + TPLH+A+
Sbjct: 683 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 742
Query: 446 RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505
G+ ++ K+LLQ++A VNAK K +PLH AA+ GHT++V LLL+N A+PN ++ G T
Sbjct: 743 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 802
Query: 506 PLHIAAREGHVET--VLALLEKEASQACMTKK 535
PL IA R G++ VL ++ E S ++ K
Sbjct: 803 PLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 834
Score = 205 bits (522), Expect = 3e-52
Identities = 123/358 (34%), Positives = 187/358 (52%), Gaps = 29/358 (8%)
Query: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517
+N+++ K D T AAR G+ + L N + N G LH+A++EGHV+
Sbjct: 33 RNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVK 92
Query: 518 TVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 577
V+ LL KE TKKG T LH+AA G+ V L+ A+ NA + G TPL++A
Sbjct: 93 MVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 152
Query: 578 HHNNLDIVKLLLPRGGSPHSPAWNGYTP-----------------------------LHI 608
N+L++VK LL G + + +G+TP LHI
Sbjct: 153 QENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHI 212
Query: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
AA+ + A LLQ + + S G TPLH+AA + + LLL++ A+ N ++G
Sbjct: 213 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 272
Query: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
+TPLH+ ++ G+V + +L+ G ++ T+ TPLH A+ G++++ + LL H A +
Sbjct: 273 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 332
Query: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
AKTK G SP+H AAQ H D V LLL+ A ++++ D TPL +A G+ V VL
Sbjct: 333 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 390
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 3005 bits (7790), Expect = 0.0
Identities = 1513/1514 (99%), Positives = 1514/1514 (100%)
Query: 1 MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM 60
MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM
Sbjct: 1 MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM 60
Query: 61 VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ
Sbjct: 61 VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
Query: 121 ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA 180
ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA
Sbjct: 121 ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA 180
Query: 181 ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 240
ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI
Sbjct: 181 ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 240
Query: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
Query: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
Query: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600
HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600
Query: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
Query: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL
Sbjct: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
Query: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780
LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI
Sbjct: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780
Query: 781 SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE 840
SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE
Sbjct: 781 SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE 840
Query: 841 KELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSD 900
KELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSD
Sbjct: 841 KELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSD 900
Query: 901 NISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLS 960
NISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLS
Sbjct: 901 NISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLS 960
Query: 961 TPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEH 1020
TPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEH
Sbjct: 961 TPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEH 1020
Query: 1021 RSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEG 1080
RSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEG
Sbjct: 1021 RSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEG 1080
Query: 1081 GSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRK 1140
GSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRK
Sbjct: 1081 GSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRK 1140
Query: 1141 FHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANEC 1200
FHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANEC
Sbjct: 1141 FHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANEC 1200
Query: 1201 ANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYC 1260
ANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYC
Sbjct: 1201 ANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYC 1260
Query: 1261 MTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRE 1320
MTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRE
Sbjct: 1261 MTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRE 1320
Query: 1321 NRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPT 1380
NRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPT
Sbjct: 1321 NRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPT 1380
Query: 1381 PLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENP 1440
PLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENP
Sbjct: 1381 PLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENP 1440
Query: 1441 NSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHT 1500
NSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHT
Sbjct: 1441 NSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHT 1500
Query: 1501 DRDYSLSPSQMNGY 1514
DRDYSLSPSQMNG+
Sbjct: 1501 DRDYSLSPSQMNGH 1514
Score = 422 bits (1086), Expect = e-117
Identities = 215/237 (90%), Positives = 218/237 (91%), Gaps = 5/237 (2%)
Query: 1650 LPGSKRQD-----DATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDRLQDWD 1704
L GS RQ D +D S ++GHQRGQARITHSPTVSQVTERSQDRLQDWD
Sbjct: 1483 LEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGHQRGQARITHSPTVSQVTERSQDRLQDWD 1542
Query: 1705 ADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTE 1764
ADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTE
Sbjct: 1543 ADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTE 1602
Query: 1765 QPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVT 1824
QPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVT
Sbjct: 1603 QPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVT 1662
Query: 1825 KKIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPSELEVDIDYFMKHSKDHTSTPNP 1881
KKIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPSELEVDIDYFMKHSKDHTSTPNP
Sbjct: 1663 KKIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPSELEVDIDYFMKHSKDHTSTPNP 1719
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 1758 bits (4554), Expect = 0.0
Identities = 971/1927 (50%), Positives = 1271/1927 (65%), Gaps = 179/1927 (9%)
Query: 8 READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
+++D+ SFLRAAR+GNLDK +++L+ G+DINTCNQNGLN LHLA+KEGHV +V ELL +
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
Query: 68 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
+++ TKKGNTALHIA+LAGQ EVV+ LV GAN+NAQSQ GFTPLYMAAQENH++VV
Sbjct: 87 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
Query: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187
K+LLENGANQ+ ATEDGFTPLAVALQQGH VA L+ TKGKVRLPALHIAAR DDT+
Sbjct: 147 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 206
Query: 188 TAAVLLQNDPNPDVLSK--------TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
+AA+LLQND N DV SK +GFTPLHIAAHY N+NVA LLLNRGA+V+FT +NG
Sbjct: 207 SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 266
Query: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
ITPLH+AS+RGN MV+LLLDRG QI+ KT+D LTPLHCAAR+GH ++ E+LL+ GAP+
Sbjct: 267 ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 326
Query: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
A+TKNGLSP+HMAAQGDH++CV+ LLQ+ A +DD+TLD+LT LHVAAHCGH+RV K+LLD
Sbjct: 327 ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 386
Query: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
K A PN+RALNGFTPLHIACKKN ++VMELL+K GASI A+TESGLTP+HVA+FMGHL I
Sbjct: 387 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 446
Query: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
V LLQ GASP+V+N++ ET LHMAARAG EV + LL+N A V+A+A+++QTPLH A+R
Sbjct: 447 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 506
Query: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
+G T +V+LLL++ A+P+ ATT G+TPLHI+AREG V+ LLE A+ + TKKGFTP
Sbjct: 507 LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 566
Query: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
LHVAAKYG + VA+LLL+R A ++AGKNGLTPLHVA H++N + LLL +G SPH+ A
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
Query: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
NGYTPLHIAAK+NQ+++A +LL YG N + QGVTPLHLA+QEGH +MV LLL K A
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 686
Query: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719
N ++ KSGLT LHL AQE V VAD+L KHG DA T++GYTPL VA HYGN+K+V F
Sbjct: 687 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 746
Query: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779
LL+ A+VNAKTK GY+PLHQAAQQGHT I+ +LL++GA PN +++G T LAIAKRLGY
Sbjct: 747 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 806
Query: 780 ISVTDVLKVVTDE--TSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAER------ 831
ISV D LKVVT+E T+ +++KH+++ PET+ E+LDVS++EG++ ++
Sbjct: 807 ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPED 866
Query: 832 ---------------------RDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETV 870
R S + L F + + R M ++V
Sbjct: 867 LKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSV 926
Query: 871 VIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSR 930
VI S + +KE + +S S TE DN++ +SP+H+GFLVSFMVDARGG+MRG R
Sbjct: 927 VIPSHQVSTLAKEAERNS-YRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCR 985
Query: 931 HNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQ------ 984
HNGLR++IPPR C APTR+TCRLVK +L+T PP+ E EGLASR+I +GP+GAQ
Sbjct: 986 HNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGKLH 1045
Query: 985 ---------------------------FLSPVIVEIPHFASHGRGDRELVVLRSENGSVW 1017
FL PVIVEIPHFA+ +RELVVLRSENG W
Sbjct: 1046 LPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVVLRSENGDSW 1105
Query: 1018 KEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIG 1077
KEH Y E L++ILNGMDE L S E+LEKKR+CRIIT DFP YF ++SR+ QD + IG
Sbjct: 1106 KEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIG 1165
Query: 1078 PEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPR 1137
PEGG L S +VP VQA FPE A+TKR+++ LQAQP+ ELV K+LGN+ATFSPIVT+EPR
Sbjct: 1166 PEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPR 1225
Query: 1138 RRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYA 1197
RRKFH+PI + IP+P + +D + GD +LRLLCS+ GGT AQWEDITGTT L +
Sbjct: 1226 RRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFV 1285
Query: 1198 NECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLR 1257
NEC +FTTNVSARFWL DC + E+V FA+ +Y+E+ VPYMAKFV+FAK +DP E RLR
Sbjct: 1286 NECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLR 1345
Query: 1258 CYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQS 1317
C+CMTDDKVDKTLEQ ENF EVARSRD+EVLEG ++ + GNLVP+ K+ Q F F +
Sbjct: 1346 CFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFA 1405
Query: 1318 FRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQH-ILCHLNITMPPCAKGSGAEDRR 1376
F+ENRL + VKVRD+++EP G LSF+++ H +C+LNIT+P K S ++ +
Sbjct: 1406 FKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQ 1465
Query: 1377 RTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIR 1436
+ SE P E+ E ++A I++HLG SW ELAREL F+ E I++IR
Sbjct: 1466 EE------EIDMTSEKNP--QDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIR 1517
Query: 1437 VENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPD 1496
+ENPNSL +QS ALL W+ R+G++A NL L I+R +IV+++E + + +
Sbjct: 1518 IENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLME-TNTEPLQERIS 1576
Query: 1497 RRHTDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATE 1556
+ + + +++ G+S LQ+EL C + +Q + E
Sbjct: 1577 HSYAEIEQTITLDHSEGFSVLQEEL-------CTAQHKQKEEQ------------AVSKE 1617
Query: 1557 HDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELG 1616
+T P +V+ ED S+ S +D K EG S P+
Sbjct: 1618 SETCDH------------PPIVSEEDISVGYSTFQDGVP-----KTEGDSSATALFPQ-- 1658
Query: 1617 SLELVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGH 1676
+ V D + + DL E+ + +E T + SE + +++
Sbjct: 1659 ----THKEQVQQDFSGKMQDLPEESSLEYQQEYFV-------TTPGTETSETQKAMI--- 1704
Query: 1677 QRGQARITHSPTVSQV-TERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGT 1735
+ S T +V T +++L YLQ G Q
Sbjct: 1705 ----VPSSPSKTPEEVSTPAEEEKL-----------YLQTPTSSE-----RGGSPIIQEP 1744
Query: 1736 STMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQ 1795
+E E ++ V+V +++ QPE + D D + ++ + T T+
Sbjct: 1745 EEPSEHREESSPRKTSLVIVESADN----QPET-CERLDEDAAFEKGDDMPEIPPETVTE 1799
Query: 1796 VVQGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEVTVEGPL 1855
E+ +E G+ V KK+ RK++R+ S E EE+ V+G
Sbjct: 1800 ------------EEYIDE-----HGHTVVKKVTRKIIRRYVSSE---GTEKEEIMVQGMP 1839
Query: 1856 EDPSELE 1862
++P +E
Sbjct: 1840 QEPVNIE 1846
Score = 404 bits (1038), Expect = e-112
Identities = 245/692 (35%), Positives = 368/692 (53%), Gaps = 41/692 (5%)
Query: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
++ + + T AA+ ++D L NG + +T ++G L +A ++GH + V
Sbjct: 122 NINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAI 181
Query: 64 LLHKE-------------------------------------IILETTTKKGNTALHIAA 86
LL + +++ TT+ G T LHIAA
Sbjct: 182 LLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAA 241
Query: 87 LAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFT 146
G V L+N GA V+ ++ G TPL++A++ + +VK LL+ G + T DG T
Sbjct: 242 HYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLT 301
Query: 147 PLAVALQQGHENVVAHLINYG----TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL 202
PL A + GH+ VV L+ G + K L LH+AA+ D LLQ+ D +
Sbjct: 302 PLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDV 361
Query: 203 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 262
+ T LH+AAH + V +LLL++ A+ N NG TPLHIA ++ + ++ LL+ G
Sbjct: 362 TLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYG 421
Query: 263 AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR 322
A I+ T+ LTP+H AA GH+ I +LL +GA G + +HMAA+ ++ VR
Sbjct: 422 ASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVR 481
Query: 323 LLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382
LL+ A +D + TPLH+A+ G + ++LL A P++ NG+TPLHI+ ++
Sbjct: 482 CLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541
Query: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLH 442
V V +LL+ GA+ T+ G TPLHVA+ G L + K LLQR A+ + + TPLH
Sbjct: 542 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 601
Query: 443 MAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA 502
+AA + +VA LL+ A +A AK+ TPLH AA+ + LL A N+ T
Sbjct: 602 VAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ 661
Query: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562
G TPLH+A++EGH + V LL+K A+ TK G T LH+AA+ KV VA++L + A
Sbjct: 662 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ 721
Query: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
+A K G TPL VA H+ N+ +V LL +G + ++ NGYTPLH AA+Q + LL
Sbjct: 722 DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL 781
Query: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Q+G NA + G T L +A + G+ +V L
Sbjct: 782 QHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
Score = 201 bits (512), Expect = 4e-51
Identities = 120/329 (36%), Positives = 178/329 (54%), Gaps = 12/329 (3%)
Query: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAARE 513
K+ ++ + K D AAR G+ + V L+ + N G LH+AA+E
Sbjct: 15 KFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKE 74
Query: 514 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 573
GHV V LL + +S TKKG T LH+A+ G+ V ++L++ A+ NA +NG TPL
Sbjct: 75 GHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 134
Query: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 633
++A N++D+VK LL G + + +G+TPL +A +Q + LL+
Sbjct: 135 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR-- 192
Query: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK--------SGLTPLHLVAQEGHVPVAD 685
+ LH+AA++ + ALLL N ++ +K SG TPLH+ A G+V VA
Sbjct: 193 --LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250
Query: 686 VLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQG 745
+L+ G VD T R G TPLHVAS GN +VK LL ++AKT+ G +PLH AA+ G
Sbjct: 251 LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSG 310
Query: 746 HTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
H +V LLL+ GA + +G +PL +A
Sbjct: 311 HDQVVELLLERGAPLLARTKNGLSPLHMA 339
Score = 181 bits (459), Expect = 6e-45
Identities = 111/335 (33%), Positives = 173/335 (51%), Gaps = 4/335 (1%)
Query: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
V R + T A+R G + L++ + NG LH++++EG V + L
Sbjct: 490 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549
Query: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
L TKKG T LH+AA G +V + L+ A ++ + G TPL++AA ++
Sbjct: 550 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQ 609
Query: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIA 180
+V LLE GA+ + ++G+TPL +A ++ + + L+NYG + K + LH+A
Sbjct: 610 KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 669
Query: 181 ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 240
++ T +LL N + +K+G T LH+AA + +NVA +L GA + + G
Sbjct: 670 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 729
Query: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
TPL +A GNV MV LL +GA + KTK+ TPLH AA+ GH I +LL HGA A
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789
Query: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335
T NG + + +A + ++ V L E+ T
Sbjct: 790 TTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTT 824
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 1749 bits (4530), Expect = 0.0
Identities = 971/1939 (50%), Positives = 1271/1939 (65%), Gaps = 191/1939 (9%)
Query: 8 READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
+++D+ SFLRAAR+GNLDK +++L+ G+DINTCNQNGLN LHLA+KEGHV +V ELL +
Sbjct: 6 QKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 65
Query: 68 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
+++ TKKGNTALHIA+LAGQ EVV+ LV GAN+NAQSQ GFTPLYMAAQENH++VV
Sbjct: 66 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125
Query: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187
K+LLENGANQ+ ATEDGFTPLAVALQQGH VA L+ TKGKVRLPALHIAAR DDT+
Sbjct: 126 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 185
Query: 188 TAAVLLQNDPNPDVLSK--------TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
+AA+LLQND N DV SK +GFTPLHIAAHY N+NVA LLLNRGA+V+FT +NG
Sbjct: 186 SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 245
Query: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
ITPLH+AS+RGN MV+LLLDRG QI+ KT+D LTPLHCAAR+GH ++ E+LL+ GAP+
Sbjct: 246 ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 305
Query: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
A+TKNGLSP+HMAAQGDH++CV+ LLQ+ A +DD+TLD+LT LHVAAHCGH+RV K+LLD
Sbjct: 306 ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 365
Query: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
K A PN+RALNGFTPLHIACKKN ++VMELL+K GASI A+TESGLTP+HVA+FMGHL I
Sbjct: 366 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 425
Query: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
V LLQ GASP+V+N++ ET LHMAARAG EV + LL+N A V+A+A+++QTPLH A+R
Sbjct: 426 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 485
Query: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
+G T +V+LLL++ A+P+ ATT G+TPLHI+AREG V+ LLE A+ + TKKGFTP
Sbjct: 486 LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 545
Query: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
LHVAAKYG + VA+LLL+R A ++AGKNGLTPLHVA H++N + LLL +G SPH+ A
Sbjct: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605
Query: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
NGYTPLHIAAK+NQ+++A +LL YG N + QGVTPLHLA+QEGH +MV LLL K A
Sbjct: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 665
Query: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719
N ++ KSGLT LHL AQE V VAD+L KHG DA T++GYTPL VA HYGN+K+V F
Sbjct: 666 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 725
Query: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779
LL+ A+VNAKTK GY+PLHQAAQQGHT I+ +LL++GA PN +++G T LAIAKRLGY
Sbjct: 726 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 785
Query: 780 ISVTDVLKVVTDE--TSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAER------ 831
ISV D LKVVT+E T+ +++KH+++ PET+ E+LDVS++EG++ ++
Sbjct: 786 ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPED 845
Query: 832 ---------------------RDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETV 870
R S + L F + + R M ++V
Sbjct: 846 LKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSV 905
Query: 871 VIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTG------------FLVSFM 918
VI S + +KE + +S S TE DN++ +SP+H+G FLVSFM
Sbjct: 906 VIPSHQVSTLAKEAERNS-YRLSWGTENLDNVALSSSPIHSGRASPCLERDNSSFLVSFM 964
Query: 919 VDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIAL 978
VDARGG+MRG RHNGLR++IPPR C APTR+TCRLVK +L+T PP+ E EGLASR+I +
Sbjct: 965 VDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEV 1024
Query: 979 GPTGAQ---------------------------------FLSPVIVEIPHFASHGRGDRE 1005
GP+GAQ FL PVIVEIPHFA+ +RE
Sbjct: 1025 GPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERE 1084
Query: 1006 LVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVI 1065
LVVLRSENG WKEH Y E L++ILNGMDE L S E+LEKKR+CRIIT DFP YF +
Sbjct: 1085 LVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAV 1144
Query: 1066 MSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQ 1125
+SR+ QD + IGPEGG L S +VP VQA FPE A+TKR+++ LQAQP+ ELV K+LGN+
Sbjct: 1145 VSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNK 1204
Query: 1126 ATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQW 1185
ATFSPIVT+EPRRRKFH+PI + IP+P + +D + GD +LRLLCS+ GGT AQW
Sbjct: 1205 ATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQW 1264
Query: 1186 EDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIF 1245
EDITGTT L + NEC +FTTNVSARFWL DC + E+V FA+ +Y+E+ VPYMAKFV+F
Sbjct: 1265 EDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVF 1324
Query: 1246 AKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVK 1305
AK +DP E RLRC+CMTDDKVDKTLEQ ENF EVARSRD+EVLEG ++ + GNLVP+
Sbjct: 1325 AKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLT 1384
Query: 1306 KAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQH-ILCHLNITMP 1364
K+ Q F F +F+ENRL + VKVRD+++EP G LSF+++ H +C+LNIT+P
Sbjct: 1385 KSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLP 1444
Query: 1365 PCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARE 1424
K S ++ + + SE P E+ E ++A I++HLG SW ELARE
Sbjct: 1445 IYTKESESDQEQEE------EIDMTSEKNP--QDEQERIEERLAYIADHLGFSWTELARE 1496
Query: 1425 LQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLE 1484
L F+ E I++IR+ENPNSL +QS ALL W+ R+G++A NL L I+R +IV+++E
Sbjct: 1497 LDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLME 1556
Query: 1485 GSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEV 1544
+ + + + + + +++ G+S LQ+EL C + +Q
Sbjct: 1557 -TNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEEL-------CTAQHKQKEEQ----- 1603
Query: 1545 AVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEG 1604
+ E +T P +V+ ED S+ S +D K EG
Sbjct: 1604 -------AVSKESETCDH------------PPIVSEEDISVGYSTFQDGVP-----KTEG 1639
Query: 1605 ALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQ 1664
S P+ + V D + + DL E+ + +E T +
Sbjct: 1640 DSSATALFPQ------THKEQVQQDFSGKMQDLPEESSLEYQQEYFV-------TTPGTE 1686
Query: 1665 DSENEVSLVSGHQRGQARITHSPTVSQV-TERSQDRLQDWDADGSIVSYLQDAAQGSWQE 1723
SE + +++ + S T +V T +++L YLQ
Sbjct: 1687 TSETQKAMI-------VPSSPSKTPEEVSTPAEEEKL-----------YLQTPTSSE--- 1725
Query: 1724 EVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQE 1783
G Q +E E ++ V+V +++ QPE + D D + +
Sbjct: 1726 --RGGSPIIQEPEEPSEHREESSPRKTSLVIVESADN----QPET-CERLDEDAAFEKGD 1778
Query: 1784 EQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAA 1843
+ + T T+ E+ +E G+ V KK+ RK++R+ S
Sbjct: 1779 DMPEIPPETVTE------------EEYIDE-----HGHTVVKKVTRKIIRRYVSSE---G 1818
Query: 1844 QEHEEVTVEGPLEDPSELE 1862
E EE+ V+G ++P +E
Sbjct: 1819 TEKEEIMVQGMPQEPVNIE 1837
Score = 404 bits (1038), Expect = e-112
Identities = 245/692 (35%), Positives = 368/692 (53%), Gaps = 41/692 (5%)
Query: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
++ + + T AA+ ++D L NG + +T ++G L +A ++GH + V
Sbjct: 101 NINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAI 160
Query: 64 LLHKE-------------------------------------IILETTTKKGNTALHIAA 86
LL + +++ TT+ G T LHIAA
Sbjct: 161 LLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAA 220
Query: 87 LAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFT 146
G V L+N GA V+ ++ G TPL++A++ + +VK LL+ G + T DG T
Sbjct: 221 HYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLT 280
Query: 147 PLAVALQQGHENVVAHLINYG----TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL 202
PL A + GH+ VV L+ G + K L LH+AA+ D LLQ+ D +
Sbjct: 281 PLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDV 340
Query: 203 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 262
+ T LH+AAH + V +LLL++ A+ N NG TPLHIA ++ + ++ LL+ G
Sbjct: 341 TLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYG 400
Query: 263 AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR 322
A I+ T+ LTP+H AA GH+ I +LL +GA G + +HMAA+ ++ VR
Sbjct: 401 ASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVR 460
Query: 323 LLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382
LL+ A +D + TPLH+A+ G + ++LL A P++ NG+TPLHI+ ++
Sbjct: 461 CLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 520
Query: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLH 442
V V +LL+ GA+ T+ G TPLHVA+ G L + K LLQR A+ + + TPLH
Sbjct: 521 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 580
Query: 443 MAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA 502
+AA + +VA LL+ A +A AK+ TPLH AA+ + LL A N+ T
Sbjct: 581 VAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ 640
Query: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562
G TPLH+A++EGH + V LL+K A+ TK G T LH+AA+ KV VA++L + A
Sbjct: 641 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ 700
Query: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
+A K G TPL VA H+ N+ +V LL +G + ++ NGYTPLH AA+Q + LL
Sbjct: 701 DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL 760
Query: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Q+G NA + G T L +A + G+ +V L
Sbjct: 761 QHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
Score = 181 bits (459), Expect = 6e-45
Identities = 111/335 (33%), Positives = 173/335 (51%), Gaps = 4/335 (1%)
Query: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
V R + T A+R G + L++ + NG LH++++EG V + L
Sbjct: 469 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 528
Query: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
L TKKG T LH+AA G +V + L+ A ++ + G TPL++AA ++
Sbjct: 529 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQ 588
Query: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIA 180
+V LLE GA+ + ++G+TPL +A ++ + + L+NYG + K + LH+A
Sbjct: 589 KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 648
Query: 181 ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 240
++ T +LL N + +K+G T LH+AA + +NVA +L GA + + G
Sbjct: 649 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 708
Query: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
TPL +A GNV MV LL +GA + KTK+ TPLH AA+ GH I +LL HGA A
Sbjct: 709 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 768
Query: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335
T NG + + +A + ++ V L E+ T
Sbjct: 769 TTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTT 803
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 1743 bits (4514), Expect = 0.0
Identities = 888/1444 (61%), Positives = 1099/1444 (76%), Gaps = 56/1444 (3%)
Query: 8 READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
+++DA S+LRAAR+G+L+KALD+++NGVDIN CNQNGLN LHLASKEGHV++V ELL +
Sbjct: 37 KKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQR 96
Query: 68 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
E ++ TKKGNTALHIA+LAGQ EVV+ LV GANVNAQSQ GFTPLYMAAQENHLEVV
Sbjct: 97 EANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVV 156
Query: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187
KFLL+NGA+Q++ATEDGFTPLAVALQQGH+ VV+ L+ TKGKVRLPALHIAAR DDT+
Sbjct: 157 KFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTK 216
Query: 188 TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 247
AA+LLQND N DV SK+GFTPLHIAAHY N+NVA LLLNR A+V+FT +N ITPLH+AS
Sbjct: 217 AAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVAS 276
Query: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307
+RGN MV+LLLDRGA+I+ KT+D LTPLHC AR+GH ++ E+LLD API +KTKNGLS
Sbjct: 277 KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLS 336
Query: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367
P+HMA QGDHL+CV+LLLQ++ +DD+T D+LT LHVAAHCGH++VAKVLLDK A PN++
Sbjct: 337 PLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAK 396
Query: 368 ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427
ALNGFTPLHIACKKN ++VMELLLK GASI AVTESGLTP+HVA+FMGH+ IV L+ G
Sbjct: 397 ALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHG 456
Query: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487
ASPN +NV+ ET LHMAAR+G EV +YL+Q+ A+V AKAKDDQTPLH +AR+G ++V+
Sbjct: 457 ASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQ 516
Query: 488 LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 547
LL+ A+PN ATT+G+TPLH++AREGH + LL+ AS + TKKGFTPLHVAAKYG
Sbjct: 517 QLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYG 576
Query: 548 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 607
K+ VA LLL++ A P+AAGK+GLTPLHVA H++N + LLL +G SPH+ A NGYTPLH
Sbjct: 577 KLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLH 636
Query: 608 IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS 667
IAAK+NQ+++A +LL+YG ANA + QG+ +HLAAQEGH +MV+LLL + AN NL NKS
Sbjct: 637 IAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKS 696
Query: 668 GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727
GLTPLHL AQE V VA+VL+ G VDA T+MGYTPLHV HYGNIK+V FLLQH A V
Sbjct: 697 GLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKV 756
Query: 728 NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
NAKTK GY+PLHQAAQQGHT I+ +LL+N ASPNE++ +G T L IA+RLGYISV D LK
Sbjct: 757 NAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLK 816
Query: 788 VVTDET-SFVLVSDKHRMSFPETVDEILDVSEDE-----------GEELISFKAERRDSR 835
+VT+ET + V++KH+M+ PET++E+LD+S+DE E IS E D+
Sbjct: 817 IVTEETMTTTTVTEKHKMNVPETMNEVLDMSDDEVRKANAPEMLSDGEYISDVEEGEDAM 876
Query: 836 DVDEEK------------------------------ELLDFVPKLDQVVESPAIPRIPCA 865
D +K L F + + R
Sbjct: 877 TGDTDKYLGPQDLKELGDDSLPAEGYMGFSLGARSASLRSFSSDRSYTLNRSSYARDSMM 936
Query: 866 MPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGS 925
+ E +V E+ ++E+D DSL S A +T DN++ V+SP+H+GFLVSFMVDARGGS
Sbjct: 937 IEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMVDARGGS 996
Query: 926 MRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQF 985
MRGSRH+G+R++IPPR C APTRITCRLVK KL+ PPP+ E EGLASR++ +GP GAQF
Sbjct: 997 MRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQF 1056
Query: 986 LSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEE 1045
L PVIVEIPHF S +REL+VLRSENG WKEH+ L ++LNGMDEEL S EE
Sbjct: 1057 LGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEE 1116
Query: 1046 LEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVK 1105
L KKR+CRIIT DFP YF ++SR+ Q+ + IGPEGG L S VPLVQA+FPE A+TKR++
Sbjct: 1117 LGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIR 1176
Query: 1106 LALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEG 1165
+ LQAQPVPDE+V K+LGN+ATFSPIVTVEPRRRKFH+PI + IP+PP + + +G
Sbjct: 1177 VGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKG 1236
Query: 1166 DTT-SLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVN 1224
DTT +LRLLCS+ GGT AQWEDITGTT L + +C +FTTNVSARFWL+DC + E V
Sbjct: 1237 DTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVG 1296
Query: 1225 FATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRD 1284
AT LY+EL VPYMAKFV+FAKMNDP E LRC+CMTDDKVDKTLEQ ENF EVARS+D
Sbjct: 1297 LATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKD 1356
Query: 1285 IEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLR 1344
IEVLEG ++ + GNL P+ K QQ F+F SF+ENRL +K+RD+S+EP G LSFL+
Sbjct: 1357 IEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLK 1416
Query: 1345 KAMKYED-TQHILCHLNITMPPCAKGSGAE--------DRRRTPTPLAL--RYSILSEST 1393
+ + Q +C+LNIT+P K + ++ DRR++ LAL RYS L+E
Sbjct: 1417 EPKTTKGLPQTAVCNLNITLPAHKKETESDQDDEIEKTDRRQSFASLALRKRYSYLTE-- 1474
Query: 1394 PGSL 1397
PG +
Sbjct: 1475 PGMI 1478
Score = 407 bits (1045), Expect = e-113
Identities = 246/684 (35%), Positives = 363/684 (53%), Gaps = 33/684 (4%)
Query: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGH---VKM 60
+V + + T AA+ +L+ L NG + ++G L +A ++GH V +
Sbjct: 132 NVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSL 191
Query: 61 VVE--------------------------LLHKEIILETTTKKGNTALHIAALAGQDEVV 94
++E LL + + +K G T LHIAA G V
Sbjct: 192 LLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVA 251
Query: 95 RELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 154
L+N A V+ ++ TPL++A++ + +VK LL+ GA + T DG TPL +
Sbjct: 252 TLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARS 311
Query: 155 GHENVVAHLINYG----TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPL 210
GHE VV L++ +K K L LH+A + D +LLQ++ D ++ T L
Sbjct: 312 GHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTAL 371
Query: 211 HIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK 270
H+AAH + VA++LL++ A+ N NG TPLHIA ++ + ++ LLL GA I+ T+
Sbjct: 372 HVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTE 431
Query: 271 DELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
LTP+H AA GHV I L+ HGA G + +HMAA+ + VR L+Q A+
Sbjct: 432 SGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQ 491
Query: 331 IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 390
++ D TPLH++A G + + LL +GA PN+ +G+TPLH++ ++ H V L
Sbjct: 492 VEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFL 551
Query: 391 LKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHT 450
L GAS+ T+ G TPLHVA+ G L + LLQ+ ASP+ + TPLH+AA +
Sbjct: 552 LDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQ 611
Query: 451 EVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510
+VA LL A +A AK+ TPLH AA+ ++ LLE A+ N T G +H+A
Sbjct: 612 KVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLA 671
Query: 511 AREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 570
A+EGHV+ V LL + A+ K G TPLH+AA+ +V VAE+L+ + AH +A K G
Sbjct: 672 AQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGY 731
Query: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
TPLHV H+ N+ IV LL ++ NGYTPLH AA+Q + LLQ S N
Sbjct: 732 TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNE 791
Query: 631 ESVQGVTPLHLAAQEGHAEMVALL 654
+V G T L +A + G+ +V L
Sbjct: 792 LTVNGNTALGIARRLGYISVVDTL 815
Score = 215 bits (547), Expect = 4e-55
Identities = 123/358 (34%), Positives = 191/358 (53%), Gaps = 29/358 (8%)
Query: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517
+ +++ K D AAR GH ++N + N+ G LH+A++EGHVE
Sbjct: 29 RKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVE 88
Query: 518 TVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 577
V LL++EA+ TKKG T LH+A+ G+ V ++L+ A+ NA +NG TPL++A
Sbjct: 89 VVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAA 148
Query: 578 HHNNLDIVKLLLPRGGSPHSPAWNGYTP-----------------------------LHI 608
N+L++VK LL G S +G+TP LHI
Sbjct: 149 QENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHI 208
Query: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
AA+++ + A LLQ +A+ ES G TPLH+AA G+ + LLL++ A + ++
Sbjct: 209 AARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND 268
Query: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
+TPLH+ ++ G+ + +L+ G +DA TR G TPLH + G+ ++V+ LL A +
Sbjct: 269 ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPIL 328
Query: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
+KTK G SPLH A Q H + V LLL++ ++V++D T L +A G+ V VL
Sbjct: 329 SKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386
Score = 107 bits (268), Expect = 8e-23
Identities = 59/144 (40%), Positives = 83/144 (57%), Gaps = 5/144 (3%)
Query: 1365 PCAKGSGAEDRRRTPTPLALRYSIL-----SESTPGSLSGTEQAEMKMAVISEHLGLSWA 1419
P A D++ PL + S G S E+ +++MA++++HLGLSW
Sbjct: 4047 PSVTTKSARDKKTEAAPLKSKSEKAGSEKRSSRRTGPQSPCERTDIRMAIVADHLGLSWT 4106
Query: 1420 ELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEI 1479
ELAREL FSV++IN+IRVENPNSL+ QS LL WV R+G+NA + L + L I+R +I
Sbjct: 4107 ELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDI 4166
Query: 1480 VNMLEGSGRQSRNLKPDRRHTDRD 1503
V +LEG N+ R D +
Sbjct: 4167 VTLLEGPIFDYGNISGTRSFADEN 4190
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 1678 bits (4346), Expect = 0.0
Identities = 866/1496 (57%), Positives = 1098/1496 (73%), Gaps = 79/1496 (5%)
Query: 8 READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
+++D+ SFLRAAR+GNLDK +++L+ G+DINTCNQNGLN LHLA+KEGHV +V ELL +
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
Query: 68 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
+++ TKKGNTALHIA+LAGQ EVV+ LV GAN+NAQSQ GFTPLYMAAQENH++VV
Sbjct: 87 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
Query: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187
K+LLENGANQ+ ATEDGFTPLAVALQQGH VA L+ TKGKVRLPALHIAAR DDT+
Sbjct: 147 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 206
Query: 188 TAAVLLQNDPNPDVLSK--------TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
+AA+LLQND N DV SK +GFTPLHIAAHY N+NVA LLLNRGA+V+FT +NG
Sbjct: 207 SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 266
Query: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
ITPLH+AS+RGN MV+LLLDRG QI+ KT+D LTPLHCAAR+GH ++ E+LL+ GAP+
Sbjct: 267 ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 326
Query: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
A+TKNGLSP+HMAAQGDH++CV+ LLQ+ A +DD+TLD+LT LHVAAHCGH+RV K+LLD
Sbjct: 327 ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 386
Query: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
K A PN+RALNGFTPLHIACKKN ++VMELL+K GASI A+TESGLTP+HVA+FMGHL I
Sbjct: 387 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 446
Query: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
V LLQ GASP+V+N++ ET LHMAARAG EV + LL+N A V+A+A+++QTPLH A+R
Sbjct: 447 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 506
Query: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
+G T +V+LLL++ A+P+ ATT G+TPLHI+AREG V+ LLE A+ + TKKGFTP
Sbjct: 507 LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 566
Query: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
LHVAAKYG + VA+LLL+R A ++AGKNGLTPLHVA H++N + LLL +G SPH+ A
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
Query: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
NGYTPLHIAAK+NQ+++A +LL YG N + QGVTPLHLA+QEGH +MV LLL K A
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 686
Query: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719
N ++ KSGLT LHL AQE V VAD+L KHG DA T++GYTPL VA HYGN+K+V F
Sbjct: 687 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 746
Query: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779
LL+ A+VNAKTK GY+PLHQAAQQGHT I+ +LL++GA PN +++G T LAIAKRLGY
Sbjct: 747 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 806
Query: 780 ISVTDVLKVVTDE--TSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAER------ 831
ISV D LKVVT+E T+ +++KH+++ PET+ E+LDVS++EG++ ++
Sbjct: 807 ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPED 866
Query: 832 ---------------------RDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETV 870
R S + L F + + R M ++V
Sbjct: 867 LKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSV 926
Query: 871 VIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSR 930
VI S + +KE + +S S TE DN++ +SP+H+GFLVSFMVDARGG+MRG R
Sbjct: 927 VIPSHQVSTLAKEAERNS-YRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCR 985
Query: 931 HNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQ------ 984
HNGLR++IPPR C APTR+TCRLVK +L+T PP+ E EGLASR+I +GP+GAQ
Sbjct: 986 HNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGKLH 1045
Query: 985 ---------------------------FLSPVIVEIPHFASHGRGDRELVVLRSENGSVW 1017
FL PVIVEIPHFA+ +RELVVLRSENG W
Sbjct: 1046 LPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVVLRSENGDSW 1105
Query: 1018 KEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIG 1077
KEH Y E L++ILNGMDE L S E+LEKKR+CRIIT DFP YF ++SR+ QD + IG
Sbjct: 1106 KEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIG 1165
Query: 1078 PEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPR 1137
PEGG L S +VP VQA FPE A+TKR+++ LQAQP+ ELV K+LGN+ATFSPIVT+EPR
Sbjct: 1166 PEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPR 1225
Query: 1138 RRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYA 1197
RRKFH+PI + IP+P + +D + GD +LRLLCS+ GGT AQWEDITGTT L +
Sbjct: 1226 RRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFV 1285
Query: 1198 NECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLR 1257
NEC +FTTNVSARFWL DC + E+V FA+ +Y+E+ VPYMAKFV+FAK +DP E RLR
Sbjct: 1286 NECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLR 1345
Query: 1258 CYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQS 1317
C+CMTDDKVDKTLEQ ENF EVARSRD+EVLEG ++ + GNLVP+ K+ Q F F +
Sbjct: 1346 CFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFA 1405
Query: 1318 FRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQH-ILCHLNITMPPCAKGSGAEDRR 1376
F+ENRL + VKVRD+++EP G LSF+++ H +C+LNIT+P K S ++ +
Sbjct: 1406 FKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQ 1465
Query: 1377 RTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDI 1432
+ + +ES TE + +K +++E L+ +L E+ +D+
Sbjct: 1466 EEEIDMTSEKNDETES-------TETSVLKSHLVNEVPVLASPDLLSEVSEMKQDL 1514
Score = 404 bits (1038), Expect = e-112
Identities = 245/692 (35%), Positives = 368/692 (53%), Gaps = 41/692 (5%)
Query: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
++ + + T AA+ ++D L NG + +T ++G L +A ++GH + V
Sbjct: 122 NINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAI 181
Query: 64 LLHKE-------------------------------------IILETTTKKGNTALHIAA 86
LL + +++ TT+ G T LHIAA
Sbjct: 182 LLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAA 241
Query: 87 LAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFT 146
G V L+N GA V+ ++ G TPL++A++ + +VK LL+ G + T DG T
Sbjct: 242 HYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLT 301
Query: 147 PLAVALQQGHENVVAHLINYG----TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL 202
PL A + GH+ VV L+ G + K L LH+AA+ D LLQ+ D +
Sbjct: 302 PLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDV 361
Query: 203 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 262
+ T LH+AAH + V +LLL++ A+ N NG TPLHIA ++ + ++ LL+ G
Sbjct: 362 TLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYG 421
Query: 263 AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR 322
A I+ T+ LTP+H AA GH+ I +LL +GA G + +HMAA+ ++ VR
Sbjct: 422 ASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVR 481
Query: 323 LLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382
LL+ A +D + TPLH+A+ G + ++LL A P++ NG+TPLHI+ ++
Sbjct: 482 CLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541
Query: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLH 442
V V +LL+ GA+ T+ G TPLHVA+ G L + K LLQR A+ + + TPLH
Sbjct: 542 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 601
Query: 443 MAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA 502
+AA + +VA LL+ A +A AK+ TPLH AA+ + LL A N+ T
Sbjct: 602 VAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ 661
Query: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562
G TPLH+A++EGH + V LL+K A+ TK G T LH+AA+ KV VA++L + A
Sbjct: 662 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ 721
Query: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
+A K G TPL VA H+ N+ +V LL +G + ++ NGYTPLH AA+Q + LL
Sbjct: 722 DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL 781
Query: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Q+G NA + G T L +A + G+ +V L
Sbjct: 782 QHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
Score = 201 bits (512), Expect = 4e-51
Identities = 120/329 (36%), Positives = 178/329 (54%), Gaps = 12/329 (3%)
Query: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAARE 513
K+ ++ + K D AAR G+ + V L+ + N G LH+AA+E
Sbjct: 15 KFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKE 74
Query: 514 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 573
GHV V LL + +S TKKG T LH+A+ G+ V ++L++ A+ NA +NG TPL
Sbjct: 75 GHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 134
Query: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 633
++A N++D+VK LL G + + +G+TPL +A +Q + LL+
Sbjct: 135 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR-- 192
Query: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK--------SGLTPLHLVAQEGHVPVAD 685
+ LH+AA++ + ALLL N ++ +K SG TPLH+ A G+V VA
Sbjct: 193 --LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250
Query: 686 VLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQG 745
+L+ G VD T R G TPLHVAS GN +VK LL ++AKT+ G +PLH AA+ G
Sbjct: 251 LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSG 310
Query: 746 HTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
H +V LLL+ GA + +G +PL +A
Sbjct: 311 HDQVVELLLERGAPLLARTKNGLSPLHMA 339
Score = 181 bits (459), Expect = 6e-45
Identities = 111/335 (33%), Positives = 173/335 (51%), Gaps = 4/335 (1%)
Query: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
V R + T A+R G + L++ + NG LH++++EG V + L
Sbjct: 490 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549
Query: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
L TKKG T LH+AA G +V + L+ A ++ + G TPL++AA ++
Sbjct: 550 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQ 609
Query: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIA 180
+V LLE GA+ + ++G+TPL +A ++ + + L+NYG + K + LH+A
Sbjct: 610 KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 669
Query: 181 ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 240
++ T +LL N + +K+G T LH+AA + +NVA +L GA + + G
Sbjct: 670 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 729
Query: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
TPL +A GNV MV LL +GA + KTK+ TPLH AA+ GH I +LL HGA A
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789
Query: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335
T NG + + +A + ++ V L E+ T
Sbjct: 790 TTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTT 824
Score = 96.3 bits (238), Expect = 3e-19
Identities = 112/463 (24%), Positives = 192/463 (41%), Gaps = 99/463 (21%)
Query: 1401 EQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQ 1460
E+ E ++A I++HLG SW ELAREL F+ E I++IR+ENPNSL +QS ALL W+ R+G+
Sbjct: 3567 ERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGK 3626
Query: 1461 NANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDE 1520
+A NL L I+R +IV+++E + + + + + + +++ G+S LQ+E
Sbjct: 3627 HATDTNLVECLTKINRMDIVHLME-TNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEE 3685
Query: 1521 LLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTA 1580
L C + +Q + E +T P +V+
Sbjct: 3686 L-------CTAQHKQKEEQ------------AVSKESETCDH------------PPIVSE 3714
Query: 1581 EDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLEQ 1640
ED S+ S +D K EG S P+ + V D + + DL E+
Sbjct: 3715 EDISVGYSTFQDGVP-----KTEGDSSATALFPQ------THKEQVQQDFSGKMQDLPEE 3763
Query: 1641 EEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVSQV-TERSQDR 1699
+ +E T + SE + +++ + S T +V T +++
Sbjct: 3764 SSLEYQQEYFV-------TTPGTETSETQKAMI-------VPSSPSKTPEEVSTPAEEEK 3809
Query: 1700 LQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSE 1759
L YLQ G Q +E E ++ V+V ++
Sbjct: 3810 L-----------YLQTPTSSE-----RGGSPIIQEPEEPSEHREESSPRKTSLVIVESAD 3853
Query: 1760 HTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQ 1819
+ QPE + D D + ++ + T T+ E+ +E
Sbjct: 3854 N----QPET-CERLDEDAAFEKGDDMPEIPPETVTE------------EEYIDE-----H 3891
Query: 1820 GNIVTKKIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPSELE 1862
G+ V KK+ RK++R+ S E EE+ V+G ++P +E
Sbjct: 3892 GHTVVKKVTRKIIRRYVSSE---GTEKEEIMVQGMPQEPVNIE 3931
>gi|32967599 ankyrin 3 isoform 2 [Homo sapiens]
Length = 1001
Score = 775 bits (2001), Expect = 0.0
Identities = 405/733 (55%), Positives = 523/733 (71%), Gaps = 7/733 (0%)
Query: 866 MPETVVIRSEEQEQA-SKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGG 924
M E +++ S+EQ ++E+D DSL S A +T DN++ V+SP+H+GFLVSFMVDARGG
Sbjct: 70 MIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMVDARGG 129
Query: 925 SMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQ 984
SMRGSRH+G+R++IPPR C APTRITCRLVK KL+ PPP+ E EGLASR++ +GP GAQ
Sbjct: 130 SMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQ 189
Query: 985 FLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLE 1044
FL PVIVEIPHF S +REL+VLRSENG WKEH+ L ++LNGMDEEL S E
Sbjct: 190 FLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPE 249
Query: 1045 ELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRV 1104
EL KKR+CRIIT DFP YF ++SR+ Q+ + IGPEGG L S VPLVQA+FPE A+TKR+
Sbjct: 250 ELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRI 309
Query: 1105 KLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGE 1164
++ LQAQPVPDE+V K+LGN+ATFSPIVTVEPRRRKFH+PI + IP+PP + + +
Sbjct: 310 RVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYK 369
Query: 1165 GDTT-SLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAV 1223
GDTT +LRLLCS+ GGT AQWEDITGTT L + +C +FTTNVSARFWL+DC + E V
Sbjct: 370 GDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETV 429
Query: 1224 NFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSR 1283
AT LY+EL VPYMAKFV+FAKMNDP E LRC+CMTDDKVDKTLEQ ENF EVARS+
Sbjct: 430 GLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSK 489
Query: 1284 DIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFL 1343
DIEVLEG ++ + GNL P+ K QQ F+F SF+ENRL +K+RD+S+EP G LSFL
Sbjct: 490 DIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFL 549
Query: 1344 RKAMKYED-TQHILCHLNITMPPCAKGSGAEDRRRTPTPLAL--RYSILSESTPGSLSGT 1400
++ + Q +C+LNIT+ P K DRR++ LAL RYS L+E S
Sbjct: 550 KEPKTTKGLPQTAVCNLNITL-PAHKKIEKTDRRQSFASLALRKRYSYLTEPGMSPQSPC 608
Query: 1401 EQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQ 1460
E+ +++MA++++HLGLSW ELAREL FSV++IN+IRVENPNSL+ QS LL WV R+G+
Sbjct: 609 ERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGK 668
Query: 1461 NANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDE 1520
NA + L + L I+R +IV +LEG N+ R D + ++ ++GY SLQ E
Sbjct: 669 NATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADEN-NVFHDPVDGYPSLQVE 727
Query: 1521 LLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTA 1580
L +P L +P + D Y+++++ +++ + L S + + P +VTA
Sbjct: 728 LETPTGLHYTPPTPFQQDDYFSDISSIESPLRTPSRLSDGLVPSQGNIEHSADGPPVVTA 787
Query: 1581 EDSSLECSKAEDS 1593
ED+SLE SK EDS
Sbjct: 788 EDASLEDSKLEDS 800
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 332 bits (852), Expect = 2e-90
Identities = 261/832 (31%), Positives = 380/832 (45%), Gaps = 99/832 (11%)
Query: 37 DINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRE 96
++N ++ G LH A+ GH +MV LL + + KK A+H AA G EVV+
Sbjct: 132 NVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKL 191
Query: 97 LVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGH 156
LV++GA V + +K +TPL+ AA + VVK+LL+ G + N G TPL VA G
Sbjct: 192 LVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQ 251
Query: 157 ENVVAHLINYGT----KGKVRLPALHIAARNDDTRTAAVLLQ-NDPNPDVLSKTGFTPLH 211
+ VV LI+ G K + LH AA + LL N + ++ SK G TPLH
Sbjct: 252 DVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLH 311
Query: 212 IAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV---------------- 255
+ A + + +Q ++ GA ++ +NG TPLHIA+R G+ +++
Sbjct: 312 MTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIH 371
Query: 256 -----------------RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
R LL G I+T T LH AA G++ +LL+ GA
Sbjct: 372 GMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADF 431
Query: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH-RVAKVL 357
K K G SP+H AA + C+ L+ A ++D+ TPLH AA + + L
Sbjct: 432 NKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYL 491
Query: 358 LDKGAKPNSRALNGF--------------------------------------------- 372
L A P R G+
Sbjct: 492 LRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATI 551
Query: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
+PLH+A H + +E+L+++ +D SG TPL +A+F GH+ V L+ +GAS V
Sbjct: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611
Query: 433 SN-VKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD---QTPLHCAARIGHTNMVKL 488
+ + TP+H AA GH+E + L+ N NA D QTPL + GHT+ V
Sbjct: 612 KDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYS 671
Query: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK 548
LL AN + G T LH A GH E V ALL+ A +G TP+H++A G
Sbjct: 672 LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGH 731
Query: 549 VRVAELLLER----DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 604
+ V LL+ DA+P A +G T LH A ++ + V+LLL + + N ++
Sbjct: 732 IGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEG-NAFS 790
Query: 605 PLHIAAKQNQVEVARSLLQYGGSA--NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
PLH A + A L+ G++ NA +G TPLH AA H E + LLLS A N
Sbjct: 791 PLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVN 850
Query: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHG-VMVDATTRMGYTPLHVASHYGNIKLVKFLL 721
+ +G TPL + A+ G ++L+ + T LH+A G+ +L
Sbjct: 851 SVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLIL 910
Query: 722 QHQAD---VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 770
+ D +NA +PLH AA+ G T +V LL GAS V +G TP
Sbjct: 911 EKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 962
Score = 327 bits (839), Expect = 5e-89
Identities = 248/812 (30%), Positives = 388/812 (47%), Gaps = 33/812 (4%)
Query: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
V +++ T RA S + + L++ D+N ++N LH+A+ VK L
Sbjct: 67 VNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126
Query: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
+ + + + G TALH AA +G E+V+ L++ GAN+NA +K ++ AA H+
Sbjct: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHI 186
Query: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIA 180
EVVK L+ +GA + +TPL A G +VV +L++ G LH+A
Sbjct: 187 EVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVA 246
Query: 181 ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI-AAHYENLNVAQLLLNRGASVNFTPQNG 239
N L+ + ++ GFTPLH AA +LL+ GA VN ++G
Sbjct: 247 CYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDG 306
Query: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
TPLH+ + G + ++ GA I+ + K+ TPLH AAR GH + L+ GA
Sbjct: 307 KTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTA 366
Query: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
+ +G+ P+H+AA DC R LL +ID T LH AA G+ +LL+
Sbjct: 367 KRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLN 426
Query: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMG-HLP 418
GA N + G +PLH A + + + L+ +GAS++ + E G TPLH A+
Sbjct: 427 TGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGK 486
Query: 419 IVKNLLQRGASPNVSNVKVETPLHMAARAGH--------TEVAKYLLQNKAKVNAKAKDD 470
++ LL+ A+P + + + +H +A GH +E +L + + + D
Sbjct: 487 CLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSD 546
Query: 471 Q----TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526
+PLH AA GH +++L+++ + ++ ++G TPL +AA +GHVE V L+ +
Sbjct: 547 NRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQG 606
Query: 527 AS---QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA---GKNGLTPLHVAVHHN 580
AS + + K+ TP+H AA G LL+ NA NG TPL ++V +
Sbjct: 607 ASILVKDYILKR--TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNG 664
Query: 581 NLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLH 640
+ D V LL +G + + G T LH A E +LLQ+G +G TP+H
Sbjct: 665 HTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIH 724
Query: 641 LAAQEGHAEMVALLL----SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696
L+A GH ++ LL S AN + G T LH GH ++L++ V
Sbjct: 725 LSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVF-QK 783
Query: 697 TTRMGYTPLHVASHYGNIKLVKFLLQ--HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
T ++PLH A N + L+ + VNA G +PLH AA H + + LLL
Sbjct: 784 TEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLL 843
Query: 755 KNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
+ A N V S G TPL +A G + ++L
Sbjct: 844 SHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875
Score = 308 bits (790), Expect = 2e-83
Identities = 233/767 (30%), Positives = 365/767 (47%), Gaps = 26/767 (3%)
Query: 15 SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
S ++A +G+ D+ + D+N + LH A+ G +++ L+ +
Sbjct: 11 SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
Query: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134
K T LH A + +E V+ L+ + A+VNA+ + TPL++AA ++ + L+
Sbjct: 71 DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
Query: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAA 190
+N NV+ G T L A GH +V L++ G K A+H AA
Sbjct: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 190
Query: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
+L+ + K +TPLH AA ++V + LL+ G +N G TPLH+A G
Sbjct: 191 LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 250
Query: 251 NVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS-EILLDHGAPIQAKTKNGLSPI 309
++V L+D GA + K + TPLH AA + H + E+L+ +GA + K+K+G +P+
Sbjct: 251 QDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPL 310
Query: 310 HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369
HM A + ++Q A ID + TPLH+AA GH + L+ GA R +
Sbjct: 311 HMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGI 370
Query: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429
+G PLH+A LL +G ID + G T LH A+ G+L + LL GA
Sbjct: 371 HGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGAD 430
Query: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG-HTNMVKL 488
N + +PLH AA + + L+ + A VN + TPLH AA ++
Sbjct: 431 FNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEY 490
Query: 489 LLENNANPNLATTAGHTPLHIAAREGH--------VETVLALLEKEASQACMT----KKG 536
LL N+ANP + G+ +H +A GH ET L +L + + ++ +
Sbjct: 491 LLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRAT 550
Query: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
+PLH+AA +G + E+L++ + +G TPL +A +++ V +L+ +G S
Sbjct: 551 ISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASIL 610
Query: 597 SPAW-NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ---GVTPLHLAAQEGHAEMVA 652
+ TP+H AA E R L+ NA +Q G TPL L+ GH + V
Sbjct: 611 VKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVY 670
Query: 653 LLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYG 712
LL+K AN + +K G T LH A GH D L++HG G TP+H+++ G
Sbjct: 671 SLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACG 730
Query: 713 NIKLVKFLLQHQADVNAKTKL----GYSPLHQAAQQGHTDIVTLLLK 755
+I ++ LLQ A ++A GY+ LH A GH V LLL+
Sbjct: 731 HIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLE 777
Score = 290 bits (741), Expect = 1e-77
Identities = 222/753 (29%), Positives = 339/753 (45%), Gaps = 80/753 (10%)
Query: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
A G + VR L+ +VN Q + TPL+ AA E+++ L+ +GA N
Sbjct: 15 AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 74
Query: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
TPL H A + VLL++ + + K
Sbjct: 75 LTPL-----------------------------HRAVASCSEEAVQVLLKHSADVNARDK 105
Query: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
TPLHIAA + + A+ L+ ++VN + + G T LH A+ G+ MV+LLL RGA
Sbjct: 106 NWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGAN 165
Query: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
I K + +H AA GH+ + ++L+ HGA + K K +P+H AA + V+ L
Sbjct: 166 INAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYL 225
Query: 325 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH- 383
L ++++ TPLHVA + G V L+D GA N + GFTPLH A H
Sbjct: 226 LDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHG 285
Query: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443
+ELL+ GA ++ ++ G TPLH+ + G + ++Q GA + + TPLH+
Sbjct: 286 ALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHI 345
Query: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503
AAR GH + L+ + A + PLH AA G ++ + LL + + + G
Sbjct: 346 AARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFG 405
Query: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
T LH AA G++E + LL A K G +PLH AA + L+ A N
Sbjct: 406 RTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVN 465
Query: 564 AAGKNGLTPLH-VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ---VEVAR 619
+ G TPLH A + ++ LL +P GY +H +A +++
Sbjct: 466 DLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIA 525
Query: 620 S------LLQYGGS---ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLT 670
S L++ G+ +++++ ++PLHLAA GH + + +L+ + ++ N SG T
Sbjct: 526 SETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRT 585
Query: 671 PLHLVAQEGHVPVADVLIKHGV-------------------------------------M 693
PL L A +GHV DVLI G
Sbjct: 586 PLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNA 645
Query: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
VD G TPL ++ G+ V LL A+V+AK K G + LH+ A GH + V L
Sbjct: 646 VDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDAL 705
Query: 754 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
L++GA S G TP+ ++ G+I V L
Sbjct: 706 LQHGAKCLLRDSRGRTPIHLSAACGHIGVLGAL 738
Score = 273 bits (699), Expect = 9e-73
Identities = 192/600 (32%), Positives = 290/600 (48%), Gaps = 16/600 (2%)
Query: 175 PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234
P+L A N D L+ + + TPLH AA+ + + +LL+ GA VN
Sbjct: 10 PSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNA 69
Query: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294
+TPLH A + V++LL A + + K+ TPLH AA N V+ +E L+
Sbjct: 70 KDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPL 129
Query: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354
+ + + G + +H AA H + V+LLL A I+ +H AA+ GH V
Sbjct: 130 LSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVV 189
Query: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414
K+L+ GA+ + +TPLH A + V++ LL G ++ G TPLHVA +
Sbjct: 190 KLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYN 249
Query: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA-KYLLQNKAKVNAKAKDDQTP 473
G +V L+ GA N N K TPLH AA + H + + L+ N A VN K+KD +TP
Sbjct: 250 GQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTP 309
Query: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
LH A G + + ++++ A + G+TPLHIAAR GH + L+ A A
Sbjct: 310 LHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRG 369
Query: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
G PLH+AA G LL + G T LH A NL+ + LLL G
Sbjct: 370 IHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGA 429
Query: 594 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA-QEGHAEMVA 652
+ G +PLH AA + +L+ G S N +G TPLH AA + + +
Sbjct: 430 DFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLE 489
Query: 653 LLLSKQANGNLGNKSGLTPLHLVAQEGH----------VPVADVLIKHG---VMVDATTR 699
LL AN + +K G +H A GH P+ DVL++ ++ D+ R
Sbjct: 490 YLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPL-DVLMETSGTDMLSDSDNR 548
Query: 700 MGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGAS 759
+PLH+A+++G+ + ++ L+Q D++ + G +PL AA +GH + V +L+ GAS
Sbjct: 549 ATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGAS 608
Score = 259 bits (662), Expect = 2e-68
Identities = 181/590 (30%), Positives = 280/590 (47%), Gaps = 17/590 (2%)
Query: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 284
L+ + VNF TPLH A+ G+ ++ LL+ GA++ K LTPLH A +
Sbjct: 27 LIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCS 86
Query: 285 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHV 344
++LL H A + A+ KN +P+H+AA + C L+ + ++ T LH
Sbjct: 87 EEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHH 146
Query: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404
AA GH + K+LL +GA N+ +H A H+ V++LL+ GA + +
Sbjct: 147 AAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS 206
Query: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464
TPLH A+ G + +VK LL G N N TPLH+A G V L+ A VN
Sbjct: 207 YTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVN 266
Query: 465 AKAKDDQTPLHCAARIGHTNM-VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523
K + TPLH AA H + ++LL+ N A+ N+ + G TPLH+ A G ++
Sbjct: 267 QKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTII 326
Query: 524 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD 583
+ A C K G TPLH+AA+YG + L+ A G +G+ PLH+A D
Sbjct: 327 QSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSD 386
Query: 584 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643
+ LL G +P G T LH AA +E LL G N + G +PLH AA
Sbjct: 387 CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446
Query: 644 QEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA-QEGHVPVADVLIKHGVMVDATTRMGY 702
+ + + L+ A+ N ++ G TPLH A + + L+++ + GY
Sbjct: 447 ANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGY 506
Query: 703 TPLHVASHYGNIKLVKFLL-QHQADVNAKT-----------KLGYSPLHQAAQQGHTDIV 750
+H ++ YG+ ++ + + DV +T + SPLH AA GH +
Sbjct: 507 NAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQAL 566
Query: 751 TLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 800
+L+++ + +S G TPL +A G++ DVL ++ + +LV D
Sbjct: 567 EVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL---INQGASILVKD 613
Score = 236 bits (602), Expect = 2e-61
Identities = 192/682 (28%), Positives = 299/682 (43%), Gaps = 65/682 (9%)
Query: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
V + D T A G ++ +++G I+ ++NG LH+A++ GH ++ L
Sbjct: 299 VNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTL 358
Query: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
+ G LH+AAL+G + R+L++ G +++ G T L+ AA +L
Sbjct: 359 ITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNL 418
Query: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIA 180
E + LL GA+ N + G +PL A + + L+ G + LH A
Sbjct: 419 ECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYA 478
Query: 181 ARND-DTRTAAVLLQNDPNPDVLSKTGF-------------------------------- 207
A +D D + LL+ND NP + K G+
Sbjct: 479 ATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSG 538
Query: 208 -------------TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIM 254
+PLH+AA++ + ++L+ ++ +G TPL +A+ +G+V
Sbjct: 539 TDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVEC 598
Query: 255 VRLLLDRGAQIETKTKD-ELTPLHCAARNGHVRISEILLDHGAP---IQAKTKNGLSPIH 310
V +L+++GA I K + TP+H AA NGH +L+ + P + + NG +P+
Sbjct: 599 VDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLM 658
Query: 311 MAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370
++ H DCV LL A +D T LH A GH LL GAK R
Sbjct: 659 LSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSR 718
Query: 371 GFTPLHIACKKNHVRVMELLLKTGASIDA----VTESGLTPLHVASFMGHLPIVKNLLQR 426
G TP+H++ H+ V+ LL++ AS+DA G T LH A + GH V+ LL++
Sbjct: 719 GRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQ 778
Query: 427 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK--VNAKAKDDQTPLHCAARIGHTN 484
+PLH A + A+ L+ VNA +TPLH AA H
Sbjct: 779 EVFQKTEG-NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVE 837
Query: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF-TPLHVA 543
++LLL +NA N + G TPL +AA G TV L+ +++ + T LH+A
Sbjct: 838 CLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLA 897
Query: 544 AKYGKVRVAELLLERDAHPNAAGKNGL---TPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600
G A L+LE+ N TPLHVA + +V+ LL +G S +
Sbjct: 898 CSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDE 957
Query: 601 NGYTPLHIAAKQNQVEVARSLL 622
NGYTP A V +L+
Sbjct: 958 NGYTPALACAPNKDVADCLALI 979
Score = 149 bits (377), Expect = 2e-35
Identities = 107/313 (34%), Positives = 145/313 (46%), Gaps = 1/313 (0%)
Query: 470 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529
DQ L A G + V+ L+ + N TPLH AA G E + L+ A
Sbjct: 8 DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
Query: 530 ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
K TPLH A ++LL+ A NA KN TPLH+A + + + L+
Sbjct: 68 NAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALV 127
Query: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649
P + + G T LH AA E+ + LL G + NA + +H AA GH E
Sbjct: 128 PLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIE 187
Query: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
+V LL+S A +K TPLH A G + V L+ GV ++ G TPLHVA
Sbjct: 188 VVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVAC 247
Query: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI-VTLLLKNGASPNEVSSDGT 768
+ G +V L+ A VN K + G++PLH AA H + + LL+ NGA N S DG
Sbjct: 248 YNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGK 307
Query: 769 TPLAIAKRLGYIS 781
TPL + G S
Sbjct: 308 TPLHMTALHGRFS 320
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 327 bits (837), Expect = 9e-89
Identities = 257/834 (30%), Positives = 387/834 (46%), Gaps = 51/834 (6%)
Query: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
T RA S + + +++ D+N ++N LH+A+ VK ++ +
Sbjct: 51 TPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV 110
Query: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
+ + G TALH AAL G E+V L+ GAN+NA +K L+ AA HL+VV L+ +
Sbjct: 111 SDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINH 170
Query: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK-GKVRL---PALHIAARNDDTRTA 189
GA + G+TPL A G NVV HL+N G + ++ + ALHIA N
Sbjct: 171 GAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVV 230
Query: 190 AVLLQNDPNPDVLSKTGFTPLHI-AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248
L+ N + + GFTPLH AA +LL+N GA VN ++G +PLH+ +
Sbjct: 231 NELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAV 290
Query: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308
G + L+ G +I+ KD TPLH AAR GH + L GA + + P
Sbjct: 291 HGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFP 350
Query: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
+H+AA H DC R LL EID T LH AA G+ K+L GA + +
Sbjct: 351 LHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKD 410
Query: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA---------SFMGHLP- 418
G TPLH A H +E L+ TGA+++ + G T LH A + +G+
Sbjct: 411 KCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHD 470
Query: 419 ------------------IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ-- 458
++ LLQ A+P++ + + +H AA GH + + LL+
Sbjct: 471 NSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERT 530
Query: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVET 518
N + + ++PLH AA GH +++LL++ + ++ G T L +AA +GH E
Sbjct: 531 NSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTEC 590
Query: 519 VLALLEKEAS---QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA---GKNGLTP 572
V AL+ AS + +TK+ TPLH + G LLLE +P A G TP
Sbjct: 591 VEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTP 648
Query: 573 LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 632
L +AV + ++D V LLL + + + G T LH E + LL+ S +
Sbjct: 649 LMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKD 708
Query: 633 VQGVTPLHLAAQEGHAEMVALLLS---KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
+G TPLH AA GHA ++ LL + + + G TPLH G+ +VL++
Sbjct: 709 SRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE 768
Query: 690 HGVMVDATTRMGYTPLHVA--SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 747
+TPLH A + +GN + + V+ + G +PL AA H
Sbjct: 769 QKCFRKFIGN-PFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHV 827
Query: 748 DIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 801
+ + LLL++ A N V + G T L +A G D+L V + + V DK
Sbjct: 828 ECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL--VNSAQADLTVKDK 879
Score = 313 bits (801), Expect = 1e-84
Identities = 241/783 (30%), Positives = 353/783 (45%), Gaps = 83/783 (10%)
Query: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
AA G+LD + +G ++ ++ G LH A+ G + +V LL+ + ++ G
Sbjct: 155 AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG 214
Query: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV-VKFLLENGANQ 137
NTALHIA GQD VV EL++YGANVN + GFTPL+ AA H + ++ L+ NGA+
Sbjct: 215 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADV 274
Query: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 197
N+ ++DG +PL H+ A + + L+QN
Sbjct: 275 NIQSKDGKSPL-----------------------------HMTAVHGRFTRSQTLIQNGG 305
Query: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 257
D + K G TPLH+AA Y + + L GA + + PLH+A+ + R
Sbjct: 306 EIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRK 365
Query: 258 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH 317
LL G +I+T K T LH AA G+V ++L GA K K G +P+H AA H
Sbjct: 366 LLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCH 425
Query: 318 LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL-------------------- 357
C+ L+ A +++ T LH AA R +L
Sbjct: 426 FHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKE 485
Query: 358 --------LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLT--P 407
L A P+ R G+ +H A H + +ELLL+ S ++SG T P
Sbjct: 486 ATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSP 545
Query: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
LH+A++ GH ++ LLQ ++ + K T L +AA GHTE + L+ A + K
Sbjct: 546 LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKD 605
Query: 468 K-DDQTPLHCAARIGHTNMVKLLLENNANP---NLATTAGHTPLHIAAREGHVETVLALL 523
+TPLH + GHT ++LLLE NP ++ G TPL +A GH++ V LL
Sbjct: 606 NVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLL 665
Query: 524 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD 583
EKEA+ + G T LH G ++LLE++ G TPLH A +
Sbjct: 666 EKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHAT 725
Query: 584 IVKLLLPRGGSPHSPAWN---GYTPLHIAA---KQNQVEVA---RSLLQYGGSANAESVQ 634
+ LL S + GYTPLH A +N +EV + ++ G+
Sbjct: 726 WLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNP------ 779
Query: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLG--NKSGLTPLHLVAQEGHVPVADVLIKHGV 692
TPLH A H +LLL + + + G TPL A HV +L++H
Sbjct: 780 -FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSA 838
Query: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQH-QADVNAKTKLGYSPLHQAAQQGHTDIVT 751
V+A G T L +A+ G V L+ QAD+ K K +PLH A +GH
Sbjct: 839 PVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCAL 898
Query: 752 LLL 754
L+L
Sbjct: 899 LIL 901
Score = 300 bits (768), Expect = 9e-81
Identities = 227/765 (29%), Positives = 350/765 (45%), Gaps = 42/765 (5%)
Query: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
L+HK + T + T LH+AA G E++ L+ GA VNA+ TPL+ A
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
Query: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQ----QGHENVVAHLINYGTKGKVRLPALHI 179
E V+ L+++ A+ N ++ TPL VA + E ++ L + + ALH
Sbjct: 62 EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHH 121
Query: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
AA N +LL N + K LH AA+ +L+V LL+N GA V + G
Sbjct: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKG 181
Query: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
TPLH A+ G + +V+ LL+ G +I+ T LH A NG + L+D+GA +
Sbjct: 182 YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVN 241
Query: 300 AKTKNGLSPIHMAAQGDH-LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
NG +P+H AA H C+ LL+ A+++ + D +PLH+ A G ++ L+
Sbjct: 242 QPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLI 301
Query: 359 DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLP 418
G + + +G TPLH+A + H ++ L +GA + PLH+A+ H
Sbjct: 302 QNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSD 361
Query: 419 IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 478
+ LL G + + T LH AA G+ E K L + A + K K +TPLH AA
Sbjct: 362 CCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAA 421
Query: 479 RIGHTNMVKLLLENNANPNLATTAGHTPLHIAARE--GHVETVLA--------------- 521
H + ++ L+ AN N G T LH AA +T+L
Sbjct: 422 ANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERAREL 481
Query: 522 -----------LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 570
LL+ +A+ + K+G+ +H AA YG + ELLLER +G
Sbjct: 482 KEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGA 541
Query: 571 T--PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628
T PLH+A ++ + +++LL G T L +AA + E +L+ G S
Sbjct: 542 TKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI 601
Query: 629 NA-ESVQGVTPLHLAAQEGHAEMVALLLSKQANG---NLGNKSGLTPLHLVAQEGHVPVA 684
++V TPLH + GH + LLL N ++ + G TPL L GH+
Sbjct: 602 FVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAV 661
Query: 685 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ 744
+L++ VD +G T LH G+ + V+ LL+ + + K G +PLH AA +
Sbjct: 662 SLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAAR 721
Query: 745 GHTDIVTLLLKNGASPNEV---SSDGTTPLAIAKRLGYISVTDVL 786
GH ++ LL+ S + + G TPL A G + +VL
Sbjct: 722 GHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVL 766
Score = 262 bits (670), Expect = 2e-69
Identities = 190/644 (29%), Positives = 295/644 (45%), Gaps = 36/644 (5%)
Query: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
+L+ + + L TPLH+AA + + +LL+ GA VN +TPLH A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 251 NVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIH 310
+ V++L+ A + + K+ TPLH AA N V+ +E+++ + + + G + +H
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
Query: 311 MAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370
AA H++ V LLL A I+ LH AA+ GH V +L++ GA+ +
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180
Query: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
G+TPLH A + V++ LL G ID + G T LH+A + G +V L+ GA+
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240
Query: 431 NVSNVKVETPLHMAARAGHTEVA-KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489
N N TPLH AA + H + + L+ N A VN ++KD ++PLH A G + L
Sbjct: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300
Query: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549
++N + G+TPLH+AAR GH + L A A PLH+AA
Sbjct: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHS 360
Query: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 609
LL + K G T LH A N++ +KLL G H G TPLH A
Sbjct: 361 DCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420
Query: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE---------GHAE----------- 649
A +L+ G + N G T LH AA G+A
Sbjct: 421 AANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARE 480
Query: 650 --------MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK--HGVMVDATTR 699
+ LL AN ++ +K G +H A GH ++L++ + ++ +
Sbjct: 481 LKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSG 540
Query: 700 MGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGAS 759
+PLH+A++ G+ + ++ LLQ D++ + + G + L AA +GHT+ V L+ GAS
Sbjct: 541 ATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGAS 600
Query: 760 ---PNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 800
+ V+ TPL + G+ +L + D V V D
Sbjct: 601 IFVKDNVTK--RTPLHASVINGHTLCLRLLLEIADNPEAVDVKD 642
Score = 188 bits (478), Expect = 4e-47
Identities = 164/606 (27%), Positives = 255/606 (42%), Gaps = 82/606 (13%)
Query: 9 EADAATSFLRAARSGNLDKALDHLR-NGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
+ D T AAR G+ + ++ LR +G D C + + LHLA+ H +LL
Sbjct: 311 DKDGNTPLHVAARYGH-ELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSS 369
Query: 68 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
++T K G T LH AA G E ++ L + GA+ + + + G TPL+ AA H +
Sbjct: 370 GFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCI 429
Query: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187
+ L+ GAN N + G T L A + L N + L + T
Sbjct: 430 ETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSE-ELERARELKEKEATL 488
Query: 188 TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS---------------- 231
LLQND NP + K G+ +H AA Y + +LLL R S
Sbjct: 489 CLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHL 548
Query: 232 -------------------VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-D 271
++ + G T L +A+ +G+ V L++ GA I K
Sbjct: 549 AAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVT 608
Query: 272 ELTPLHCAARNGHVRISEILL---DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328
+ TPLH + NGH +LL D+ + K G +P+ +A H+D V LLL+ +
Sbjct: 609 KRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKE 668
Query: 329 AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVME 388
A +D + + T LH GH ++LL++ + G TPLH A + H +
Sbjct: 669 ANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLS 728
Query: 389 LLLKTGASIDAVT---ESGLTPLHVASFMGHLPIVKNLLQR------------------- 426
LL+ S + G TPLH A + G+ ++ LL++
Sbjct: 729 ELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAII 788
Query: 427 ---------------GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQ 471
+ + + K TPL AA A H E + LL++ A VNA +
Sbjct: 789 NDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGK 848
Query: 472 TPLHCAARIGHTNMVKLLLENNANPNLATTAG--HTPLHIAAREGHVETVLALLEKEASQ 529
T L AA G V +L+ N+A +L +TPLH+A +GH + L +L+K +
Sbjct: 849 TALMMAAENGQAGAVDILV-NSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDE 907
Query: 530 ACMTKK 535
+ + +K
Sbjct: 908 SLINEK 913
Score = 95.5 bits (236), Expect = 4e-19
Identities = 78/296 (26%), Positives = 127/296 (42%), Gaps = 32/296 (10%)
Query: 2 PYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMV 61
P +V ++A T + A G++D L +++T + G LH GH + V
Sbjct: 635 PEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECV 694
Query: 62 VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN---AQSQKGFTPLYMA 118
LL +E+ + +G T LH AA G + EL+ + + +G+TPL+ A
Sbjct: 695 QMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWA 754
Query: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH 178
+ ++ LLE + + FTPL A+ H N + L+ + +
Sbjct: 755 CYNGNENCIEVLLEQKCFRKF-IGNPFTPLHCAIINDHGNCASLLLG-------AIDSSI 806
Query: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
++ R+D G TPL AA +++ QLLL A VN +
Sbjct: 807 VSCRDD--------------------KGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNS 846
Query: 239 GITPLHIASRRGNVIMVRLLLDRG-AQIETKTKDELTPLHCAARNGHVRISEILLD 293
G T L +A+ G V +L++ A + K KD TPLH A GH + + ++LD
Sbjct: 847 GKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILD 902
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 315 bits (808), Expect = 2e-85
Identities = 206/601 (34%), Positives = 312/601 (51%), Gaps = 14/601 (2%)
Query: 182 RNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGIT 241
R D RT LL N + + G T L AA+ +L+V LL++RGA + +G T
Sbjct: 524 REDSIRT---LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHT 580
Query: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301
PL +A+R+G+ +V L+ GA I +D T L AA GH + LL G +
Sbjct: 581 PLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCA 640
Query: 302 TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG 361
+ + + AA G H D V LLQ+ AE++ + T L AA+ GH + + LLD G
Sbjct: 641 DADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 700
Query: 362 AKPNSRALNGFTPLHIAC-----KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416
A+ N ++G T L +A K H V+ LL+ GA +D + G+TPL VA++ GH
Sbjct: 701 AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGH 760
Query: 417 LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 476
+ +V LL+ GA + ++ TPL AA GH V LL A V++ + +T L
Sbjct: 761 VDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSI 820
Query: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
A+ G+ +V+ LL+ + N AG TPLH+AA EGH AL+E+ A + G
Sbjct: 821 ASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880
Query: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
P +A++ G ++LLE ++ + G +G L VA + DIV+LL G +
Sbjct: 881 RIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVN 940
Query: 597 SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656
+G L+I A +NQ+ +A L+ G + A +G T LH++ +GH EMV +L++
Sbjct: 941 CKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIA 1000
Query: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716
A+ N + + L A +GHV V +LI+HG +VD T G T L +A+ G+I +
Sbjct: 1001 YHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDV 1060
Query: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK------NGASPNEVSSDGTTP 770
V+ LL+H AD N + G + + AA+ GH+ I+ LL K NG SP+ V + P
Sbjct: 1061 VQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKP 1120
Query: 771 L 771
L
Sbjct: 1121 L 1121
Score = 282 bits (722), Expect = 2e-75
Identities = 206/686 (30%), Positives = 327/686 (47%), Gaps = 42/686 (6%)
Query: 90 QDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 149
+ EV++ LV GA+VN++ + + A + + ++ LL+NGA+ N +G T LA
Sbjct: 493 EQEVLQLLVKAGAHVNSEDDRTSCIVRQALERE--DSIRTLLDNGASVNQCDSNGRTLLA 550
Query: 150 VALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 209
A G +VV L++ G + ++ G TP
Sbjct: 551 NAAYSGSLDVVNLLVSRGA-----------------------------DLEIEDAHGHTP 581
Query: 210 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 269
L +AA + V L+ GA++N T Q+G T L A+ G+ +V LL G +++
Sbjct: 582 LTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCAD 641
Query: 270 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 329
D T L AA GH I LL HGA + G + + AA H + V LL + A
Sbjct: 642 ADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGA 701
Query: 330 EIDDITLDHLTPLHVAAHC-----GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHV 384
E++ +D T L VAA C GH V +L+D+GA+ + +G TPL +A + HV
Sbjct: 702 EVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHV 761
Query: 385 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
V++LLL+ GA +D +G TPL A+ MGH +V LL GA+ + + + T L +A
Sbjct: 762 DVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIA 821
Query: 445 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH 504
+ G+ EV + LL N + TPLH AA GH + + L+E A N G
Sbjct: 822 SAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGR 881
Query: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564
P +A++EGH + V LLE +++ G L VAA G + ELL A N
Sbjct: 882 IPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNC 941
Query: 565 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624
+G L++ N L + + L G + + G T LH++ Q +E+ + L+ Y
Sbjct: 942 KDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAY 1001
Query: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
NA + + L AA +GH ++V LL+ A + G T L + AQEGH+ V
Sbjct: 1002 HADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVV 1061
Query: 685 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ 744
VL++HG + + G T + VA+ G+ +++K L ++ A ++ SP+H Q+
Sbjct: 1062 QVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA--SSLNGCSPSPVHTMEQK 1119
Query: 745 G----HTDIVTLLLKNGASPNEVSSD 766
+ + +L +K+ +S + D
Sbjct: 1120 PLQSLSSKVQSLTIKSNSSGSTGGGD 1145
Score = 281 bits (719), Expect = 4e-75
Identities = 184/568 (32%), Positives = 280/568 (49%), Gaps = 5/568 (0%)
Query: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 284
LL+ GASVN NG T L A+ G++ +V LL+ RGA +E + TPL AAR GH
Sbjct: 531 LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGH 590
Query: 285 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHV 344
++ L+ GA I ++G + + AA G H + V LL ++D D T L
Sbjct: 591 TKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRA 650
Query: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404
AA GH + LL GA+ N G T L A H ++E LL GA ++ G
Sbjct: 651 AAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDG 710
Query: 405 LTPLHVASFM-----GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 459
T L VA+ GH +V L+ RGA + + TPL +AA GH +V LL+
Sbjct: 711 RTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEG 770
Query: 460 KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519
A V+ + +TPL AA +GH ++V LL A + + G T L IA+ +G+VE V
Sbjct: 771 GADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVV 830
Query: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHH 579
LL++ + G+TPLH+AA G + E L+E+ A N +G P +A
Sbjct: 831 RTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQE 890
Query: 580 NNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPL 639
+ D V++LL + ++G L +AA + ++ L +G N + G L
Sbjct: 891 GHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTL 950
Query: 640 HLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTR 699
++ A E M L AN + G T LH+ +GH+ + VLI + V+A
Sbjct: 951 YILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADN 1010
Query: 700 MGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGAS 759
+ L A+ G++K+V+ L++H A V+ G + L AAQ+GH D+V +LL++GA
Sbjct: 1011 EKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGAD 1070
Query: 760 PNEVSSDGTTPLAIAKRLGYISVTDVLK 787
PN G T + +A + G+ + +L+
Sbjct: 1071 PNHADQFGRTAMRVAAKNGHSQIIKLLE 1098
Score = 270 bits (690), Expect = 1e-71
Identities = 185/570 (32%), Positives = 288/570 (50%), Gaps = 11/570 (1%)
Query: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
+A T AAR G+ + G +IN +Q+G L A+ GH ++V LL+
Sbjct: 575 DAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAG 634
Query: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
+ ++ TAL AA G +++V L+ +GA VN +G T L AA H E+V+
Sbjct: 635 VKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVE 694
Query: 129 FLLENGANQNVATEDGFTPLAVAL-----QQGHENVVAHLINYGTK----GKVRLPALHI 179
LL++GA N DG T L+VA +GH +VV+ LI+ G + K + L +
Sbjct: 695 HLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLV 754
Query: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
AA +LL+ + D G TPL AA + +V LL GA+V+ G
Sbjct: 755 AAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEG 814
Query: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
T L IAS +GNV +VR LLDRG + TPLH AA GH I E L++ GA
Sbjct: 815 RTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTN 874
Query: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
+G P +A+Q H DCV++LL+ + ID D L VAA GH + ++L
Sbjct: 875 EIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFS 934
Query: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
GA N + +G L+I +N + + E L+ GA+++A G T LHV+ + GH+ +
Sbjct: 935 HGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEM 994
Query: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
V+ L+ A N ++ + + L AA GH +V + L+++ A V+ T L AA+
Sbjct: 995 VQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQ 1054
Query: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
GH ++V++LLE+ A+PN A G T + +AA+ GH + ++ LLEK + + + +P
Sbjct: 1055 EGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQ-IIKLLEKYGASS-LNGCSPSP 1112
Query: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNG 569
+H + ++ + N++G G
Sbjct: 1113 VHTMEQKPLQSLSSKVQSLTIKSNSSGSTG 1142
Score = 156 bits (394), Expect = 2e-37
Identities = 131/456 (28%), Positives = 197/456 (43%), Gaps = 77/456 (16%)
Query: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA---GHTEVAKYLLQNKA 461
LTPL F HL I NL A + + TP+ + EV + L++ A
Sbjct: 447 LTPLEAQEFALHL-INSNLQLETAELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGA 505
Query: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521
VN++ DD+T + + ++ LL+N A+ N + G T L AA G ++ V
Sbjct: 506 HVNSE--DDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNL 563
Query: 522 LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN 581
L+ + A G TPL +AA+ G +V L+ A+ N ++G T L A +
Sbjct: 564 LVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGH 623
Query: 582 LDIVKLLLPRG-----------GSPHSPAWNGY----------------------TPLHI 608
++V LL G + + AW G+ T L
Sbjct: 624 TEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIA 683
Query: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA-----AQEGHAEMVALLLSKQANGNL 663
AA E+ LL +G N E V G T L +A A +GHA +V+LL+ + A +
Sbjct: 684 AAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDH 743
Query: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP------------------- 704
+K G+TPL + A EGHV V D+L++ G VD T G TP
Sbjct: 744 CDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFW 803
Query: 705 --------------LHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
L +AS GN+++V+ LL D N + G++PLH AA +GH I
Sbjct: 804 GAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLIC 863
Query: 751 TLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
L++ GA NE+ +DG P +A + G+ +L
Sbjct: 864 EALIEQGARTNEIDNDGRIPFILASQEGHYDCVQIL 899
Score = 92.4 bits (228), Expect = 4e-18
Identities = 54/163 (33%), Positives = 86/163 (52%)
Query: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
V ++AD + A L A L NG ++ + G LH++ +GH++MV L
Sbjct: 939 VNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL 998
Query: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
+ + + +AL AA G +VV+ L+ +GA V+ +G T L +AAQE H+
Sbjct: 999 IAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHI 1058
Query: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
+VV+ LLE+GA+ N A + G T + VA + GH ++ L YG
Sbjct: 1059 DVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYG 1101
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
Length = 2352
Score = 305 bits (781), Expect = 3e-82
Identities = 290/994 (29%), Positives = 433/994 (43%), Gaps = 110/994 (11%)
Query: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
T + AA G++ L + D+N + G L A G+V +V LL +E
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
Query: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132
+ G+T L A AG EV R L+ GA +N S + + L +A + HLE+V+FLLE
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
Query: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------LHIAARNDDT 186
GA+Q T++ T L A GH V L++ G +V +PA L +AA
Sbjct: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPLTLAACGGHV 480
Query: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHI 245
AA+L++ + + ++ G+TPL AA + + LLL +GA++N T + T L +
Sbjct: 481 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
Query: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
A G + + L+ GA IE TPL AA+ GH+ + + LL GA + A T G
Sbjct: 541 ACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATG 597
Query: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
+ + A + H D +LLQ A+++ + TPL AA GH + L+ KGA N
Sbjct: 598 DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVN 657
Query: 366 -SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
+ A N T L +AC H+ V+ELLL GA + G T L A+ GH +V LL
Sbjct: 658 RTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
Query: 425 QRG----ASPNVSNVKVETPLHMAARAGHTEV--------------------AKYLLQNK 460
++P ++ P H RA V ++NK
Sbjct: 718 DYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNK 777
Query: 461 AKVNAKAKDDQTPLH-CAARIGH----------TNMVKLLLENNANPNLATTAGH-TPLH 508
A + TP H AA I + L + + + T + H T L
Sbjct: 778 AVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALT 837
Query: 509 IAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 568
+A GH E V LLE+ AS KKGFTPL +AA G V V E+LL+ A A +
Sbjct: 838 LACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSER 897
Query: 569 GL-TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 627
TPL +A ++V+LLL RG + + YTPL +AA V + + LL G
Sbjct: 898 TKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAE 957
Query: 628 ANAE--SVQGVTPLHLAAQEGH----------------------------------AEMV 651
N+ S G++PL LAA GH E+V
Sbjct: 958 INSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVV 1017
Query: 652 ALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA--TTRMGYTPLHVAS 709
+LLL ++AN K+GLTPL A G+ V VL+ G V+A T L +A+
Sbjct: 1018 SLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAA 1077
Query: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769
G+ K + L+ A ++ + K G +PL AA GH D+V LL++ GA + + T
Sbjct: 1078 DKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKIT 1137
Query: 770 PLAIAKRLGYISVTDVL-KVVTDETS-------FVLVSDKHRMS----FPETVDEILDVS 817
PL A R G++ V L K V S ++DK + E++ + D
Sbjct: 1138 PLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQ 1197
Query: 818 EDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVES---------PAIPRIPCAMPE 868
E + S E D + EE L K ++ E + I E
Sbjct: 1198 AAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKE 1257
Query: 869 TVVIRSEEQEQASKEYDEDSLIPSSPATETSDNI 902
+++ ++++ K DE ++ P+ T+ I
Sbjct: 1258 NFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTI 1291
Score = 293 bits (750), Expect = 1e-78
Identities = 265/859 (30%), Positives = 406/859 (47%), Gaps = 67/859 (7%)
Query: 15 SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
S A G+++ L G +N + G + L LA G+ ++ LL +E
Sbjct: 237 SLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 296
Query: 75 TKKGN-TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
KG+ T L AA G ++V+ L+ + A+VNAQS G T L A +++VVK LLE+
Sbjct: 297 GIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES 356
Query: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRT 188
GA+ E+G TPL A GH V L+ G + + AL +A
Sbjct: 357 GASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEM 416
Query: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248
LL+ + + + T L A ++ VA+LLL+ GA VN + +PL +A+
Sbjct: 417 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 476
Query: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-S 307
G+V + LL++RGA +E + TPL AAR GH + +LL GA I A+T+ +
Sbjct: 477 GGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQET 536
Query: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367
+ +A G L+ L++ A DI L TPL AA GH + K LL GA ++
Sbjct: 537 ALTLACCGGFLEVADFLIKAGA---DIELGCSTPLMEAAQEGHLELVKYLLAAGANVHAT 593
Query: 368 ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427
G T L AC+ H V ++LL+ GA ++ +E G TPL A+ GH+ V+ L+ +G
Sbjct: 594 TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKG 653
Query: 428 ASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486
A+ N + + T L +A GH V + LL + A + KD T L AA+ GHT++V
Sbjct: 654 ANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVV 713
Query: 487 KLLLENNAN------PNLA--TTAGH------------TPLHIAARE-----GHVETVLA 521
LL+ N P++ T H P+ + +E +V T L
Sbjct: 714 CYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLP 773
Query: 522 LLEKEASQACMTKKGFTPLH-VAAKYGK---------VRVAELL-----LERDAHPNAAG 566
+ K S TP H +AA + + + +L ++ DA +
Sbjct: 774 IRNKAVSGRASAMSN-TPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTES-- 830
Query: 567 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626
N T L +A + ++V+ LL RG S G+TPL +AA V V LL G
Sbjct: 831 -NHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGA 889
Query: 627 SANAESVQGV-TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVAD 685
A+S + TPL LA G E+V LLL++ AN N S TPL L A G+V +
Sbjct: 890 DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 949
Query: 686 VLIKHGVMVDATT--RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG-YSPLHQAA 742
+L+ G +++ T ++G +PL +A+ G+ VK LL +D+NA+ + + L A
Sbjct: 950 ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1009
Query: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKH 802
QG T++V+LLL A+ + G TPL A GY +V +V+ D+ +D +
Sbjct: 1010 FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGY---AEVGRVLLDKG-----ADVN 1061
Query: 803 RMSFPETVDEILDVSEDEG 821
P + D L ++ D+G
Sbjct: 1062 APPVPSSRDTALTIAADKG 1080
Score = 282 bits (721), Expect = 2e-75
Identities = 257/851 (30%), Positives = 383/851 (45%), Gaps = 115/851 (13%)
Query: 17 LRAARSGNLDKALDHLRNGVDINTCN--QNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
L ++ S LD+A L +T N Q+ L A EG V V +LL + +
Sbjct: 204 LTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEH 263
Query: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG-FTPLYMAAQENHLEVVKFLLEN 133
T++G + L +A AG E+ + L+ ANV + KG TPL AA H+++VK LL +
Sbjct: 264 TEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAH 323
Query: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLL 193
A+ N + G T L A G+ +VV VLL
Sbjct: 324 KADVNAQSSTGNTALTYACAGGYVDVV-----------------------------KVLL 354
Query: 194 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI--TPLHIASRRGN 251
++ + + ++ G TPL A ++ VA+LLL GA +N T N + L +A +G+
Sbjct: 355 ESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN-THSNEFKESALTLACYKGH 413
Query: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 311
+ MVR LL+ GA E KT + T L A +GHV ++ +LLD GA + + SP+ +
Sbjct: 414 LEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 473
Query: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA-LN 370
AA G H++ LL++ A ++++ + TPL AA GH + +LL +GA N++
Sbjct: 474 AACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEET 533
Query: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
T L +AC + V + L+K GA I+ TPL A+ GHL +VK LL GA+
Sbjct: 534 QETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANV 590
Query: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490
+ + +T L A GHT+VA LLQ A + +++ +TPL AAR GH V+ L+
Sbjct: 591 HATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLI 650
Query: 491 ENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549
AN N T HT L +A GH+ V LL A K G T L AAK G
Sbjct: 651 SKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 710
Query: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNN------LDIVKLLLPRGGSPHSPAWNGY 603
V LL+ + +A +T L H N + + +++P P P N
Sbjct: 711 SVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVP-PQEPDKPPANVA 769
Query: 604 T--PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTP----------------------- 638
T P+ A + + + +A+ Q TP
Sbjct: 770 TTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTE 829
Query: 639 ------LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692
L LA GH E+V LL + A+ +K G TPL L A GHV V ++L+ +G
Sbjct: 830 SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGA 889
Query: 693 MVDATTR----------------------------------MGYTPLHVASHYGNIKLVK 718
++A + YTPL +A+ G + ++K
Sbjct: 890 DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 949
Query: 719 FLLQHQADVNAKT--KLGYSPLHQAAQQGHTDIVTLLLKNGASPN-EVSSDGTTPLAIAK 775
LL A++N++T KLG SPL AA GHT V LLL G+ N ++ ++ T L +A
Sbjct: 950 ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1009
Query: 776 RLGYISVTDVL 786
G V +L
Sbjct: 1010 FQGRTEVVSLL 1020
Score = 225 bits (574), Expect = 3e-58
Identities = 189/604 (31%), Positives = 292/604 (48%), Gaps = 32/604 (5%)
Query: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
E +T + AA+ G+L+ L G +++ G L A + GH + LL
Sbjct: 561 ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAG 620
Query: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVV 127
LE ++ G T L AA AG V+ L++ GANVN + T L +A HL VV
Sbjct: 621 ADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVV 680
Query: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA----ARN 183
+ LL +GA+ +DG T L A + GH +VV +L++Y + P + +
Sbjct: 681 ELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDY-PNNLLSAPPPDVTQLTPPSH 739
Query: 184 DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI--- 240
D R V +Q P + P ++A N A + R ++++ TP + I
Sbjct: 740 DLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKA--VSGRASAMSNTPTHSIAAS 797
Query: 241 -------TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
TP I S ++ + +D AQ E+ LT L CA GH + + LL+
Sbjct: 798 ISQPQTPTPSPIISPSA-MLPIYPAIDIDAQTESNHDTALT-LACA--GGHEELVQTLLE 853
Query: 294 HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID---DITLDHLTPLHVAAHCGH 350
GA I+ + K G +P+ +AA H+ V +LL A+I+ + T D TPL +A G
Sbjct: 854 RGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD--TPLSLACSGGR 911
Query: 351 HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTES--GLTPL 408
V ++LL +GA R ++ +TPL +A +V ++++LL GA I++ T S G++PL
Sbjct: 912 QEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPL 971
Query: 409 HVASFMGHLPIVKNLLQRGASPNVS-NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
+A+ GH VK LL G+ N T L +A G TEV LL KA V +A
Sbjct: 972 MLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA 1031
Query: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNL--ATTAGHTPLHIAAREGHVETVLALLEK 525
K TPL AA G+ + ++LL+ A+ N ++ T L IAA +GH + L+ +
Sbjct: 1032 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGR 1091
Query: 526 EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIV 585
A KKG TPL +AA G + V +LL++ A +AA +TPL A ++ +V
Sbjct: 1092 GAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVV 1151
Query: 586 KLLL 589
+ L+
Sbjct: 1152 RYLV 1155
Score = 31.2 bits (69), Expect = 10.0
Identities = 20/65 (30%), Positives = 31/65 (47%), Gaps = 1/65 (1%)
Query: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
+ R T AA G+LD ++ G D++ + + L A ++GHVK VV
Sbjct: 1095 IDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVK-VVRY 1153
Query: 65 LHKEI 69
L KE+
Sbjct: 1154 LVKEV 1158
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 297 bits (760), Expect = 7e-80
Identities = 260/831 (31%), Positives = 366/831 (44%), Gaps = 92/831 (11%)
Query: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
AA G+L+ + G D+ ++ G LH A+ G +++V LL ++ G
Sbjct: 180 AAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFG 239
Query: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA-QENHLEVVKFLLENGANQ 137
NTALHIA GQD V ELVN GANVN + KGFTPL++AA N ++ L+ NGA+
Sbjct: 240 NTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADV 299
Query: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLL 193
N +++G +PL +A G LI G++ K LH+AAR + L+
Sbjct: 300 NYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLM 359
Query: 194 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA--------------SVNF---TP 236
N + PLH+A + + + LL+ G S F TP
Sbjct: 360 TNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTP 419
Query: 237 QN-GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
N G T LH A+ GNV + LLL GA + + K TPLH AA NG + + L+ G
Sbjct: 420 DNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAG 479
Query: 296 APIQAKTKNGLSPIHMAAQGDHLDCVR--LLLQYDAEIDDITLDHLTPLHVAAHCGHHRV 353
A + G SP+H AA D +DAE D+ PL +
Sbjct: 480 AGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDE-------PLKESRRKEAFFC 532
Query: 354 AKVLLDKGAKPNSRALNGFT-----------------------------------PLHIA 378
+ LLD GA P+ R G+T PLH+A
Sbjct: 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLA 592
Query: 379 CKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE 438
H ++ L +T ++D G T L +A+ G V+ L GAS + K +
Sbjct: 593 AYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRK 652
Query: 439 -TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD---QTPLHCAARIGHTNMVKLLLENNA 494
TPLH AA +GHT+ L+ + + + D QTPL A GH + V LLLE +
Sbjct: 653 WTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGS 712
Query: 495 NPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAEL 554
+ A G T LH A G + + ALL+ +A C KG TP+H+A+ G V
Sbjct: 713 TADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRT 772
Query: 555 LLER--DAHPNAAGKN--GLTPLHVAVHHNNLDIVKLLLPRGGSPHSP----AWNGYTPL 606
LL+ P AG + G +P+H A + + D ++LLL HSP N +TPL
Sbjct: 773 LLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE-----HSPFSYLEGNPFTPL 827
Query: 607 HIAAKQNQVEVARSLLQYGGS--ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
H A NQ LL G+ N+ +G TPLH AA + + +LL QA N
Sbjct: 828 HCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNAT 887
Query: 665 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATT--RMGYTPLHVASHYGNIKLVKFLLQ 722
+ +G T L A+ G + L+ G D T T LH+A G+ K +L
Sbjct: 888 DHTGRTALMTAAENGQTAAVEFLLYRG-KADLTVLDENKNTALHLACSKGHEKCALMILA 946
Query: 723 HQAD---VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 770
D +NA PLH AA+ G +V LL +GA+ V +G TP
Sbjct: 947 ETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTP 997
Score = 286 bits (732), Expect = 1e-76
Identities = 226/744 (30%), Positives = 329/744 (44%), Gaps = 60/744 (8%)
Query: 114 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI----NYGTK 169
PL A +E V+ LL N NV ++ TPL A G ++ L+ N K
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
Query: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229
+ L LH AA + + + +LL + + + K TPLH+AA A+ L
Sbjct: 71 DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130
Query: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
+S+N ++G + LH A G++ V LLL++GA + K E PLH AA GH+ + +
Sbjct: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLK 190
Query: 290 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 349
+L+ GA + K + G +H AA ++ V+ LL+ AEID+ T LH+A + G
Sbjct: 191 LLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLG 250
Query: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIAC-KKNHVRVMELLLKTGASIDAVTESGLTPL 408
VA L++ GA N GFTPLH+A N +ELL+ GA ++ ++ G +PL
Sbjct: 251 QDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPL 310
Query: 409 HVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAK 468
H+A+ G + L+Q G+ + ++ TPLH+AAR GH + L+ N A +
Sbjct: 311 HMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGI 370
Query: 469 DDQTPLHCAARIGHTNMVKLLLENNA------------------NPNLATTAGHTPLHIA 510
D PLH A G ++ + LL + + N G T LH A
Sbjct: 371 HDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAA 430
Query: 511 AREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 570
A G+VE + LL A K G TPLH AA G + A L+ A N A G
Sbjct: 431 ASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGC 490
Query: 571 TPLHVAV---------------HHNNLD-------------IVKLLLPRGGSPHSPAWNG 602
+PLH A H D ++ LL G P G
Sbjct: 491 SPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQG 550
Query: 603 YTPLHIAAKQNQVEVARSLLQ--YGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
YT +H AA + LL+ + + ES V+PLHLAA GH E + L N
Sbjct: 551 YTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVN 610
Query: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTR-MGYTPLHVASHYGNIKLVKF 719
++ + G T L L + G +VL HG R +TPLH A+ G+ +
Sbjct: 611 LDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHL 670
Query: 720 LLQ--HQADV-NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKR 776
L+ +AD+ + G +PL A GH D V LLL+ G++ + G T L R
Sbjct: 671 LIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTAL---HR 727
Query: 777 LGYISVTDVLKVVTDETSFVLVSD 800
D L + D +FVL D
Sbjct: 728 GAVTGCEDCLAALLDHDAFVLCRD 751
Score = 285 bits (730), Expect = 2e-76
Identities = 253/863 (29%), Positives = 371/863 (42%), Gaps = 98/863 (11%)
Query: 14 TSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILE 72
T RAA S N +K L L + D+N ++ LH+A+ K L L
Sbjct: 76 TPLHRAAASRN-EKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLN 134
Query: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
+ G +ALH A +G E V L+N GA++N +K PL+ AA HLEV+K L+
Sbjct: 135 VADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVA 194
Query: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRT 188
GA+ G+ L A G VV +L+ G + ALHIA
Sbjct: 195 RGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAV 254
Query: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA-QLLLNRGASVNFTPQNGITPLHIAS 247
A L+ N + + GFTPLH+AA N + +LL+N GA VN+ + G +PLH+A+
Sbjct: 255 AIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAA 314
Query: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307
G ++L+ G++I+ K TPLH AAR GH + L+ +GA + + +
Sbjct: 315 IHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMF 374
Query: 308 PIHMAAQGDHLDCVRLLLQ----------------YDAEIDDITLDHL--TPLHVAAHCG 349
P+H+A DC R LL A D T D+L T LH AA G
Sbjct: 375 PLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGG 434
Query: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLH 409
+ +LL GA R G TPLH A + L+ GA ++ G +PLH
Sbjct: 435 NVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLH 494
Query: 410 VASFMG-------HLP---------------------IVKNLLQRGASPNVSNVKVETPL 441
A+ H P ++ LL GA P++ + + T +
Sbjct: 495 YAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAV 554
Query: 442 HMAARAGHTEVAKYLLQNKAKV--NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 499
H AA G+ + + LL+ + ++ +PLH AA GH +K L E N ++
Sbjct: 555 HYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVR 614
Query: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACM-TKKGFTPLHVAAKYGKVRVAELLL-- 556
G T L +A G E V L AS K+ +TPLH AA G LL+
Sbjct: 615 DHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDS 674
Query: 557 -ERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615
ER + G TPL +A+ + ++D V LLL +G + + G T LH A
Sbjct: 675 GERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCE 734
Query: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL----GNKSGLTP 671
+ +LL + +G TP+HLA+ GH ++ LL + + + SG +P
Sbjct: 735 DCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSP 794
Query: 672 LHLVAQEGHVPVADVLIKHGVM------------------VDATTRM------------- 700
+H + GH ++L++H D+TT M
Sbjct: 795 MHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSR 854
Query: 701 ---GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 757
G TPLH A+ N+ ++ LLQHQA+VNA G + L AA+ G T V LL G
Sbjct: 855 DAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRG 914
Query: 758 -ASPNEVSSDGTTPLAIAKRLGY 779
A + + T L +A G+
Sbjct: 915 KADLTVLDENKNTALHLACSKGH 937
Score = 260 bits (664), Expect = 1e-68
Identities = 208/698 (29%), Positives = 305/698 (43%), Gaps = 86/698 (12%)
Query: 175 PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234
P L A + D LL N +VL + TPLH AA+ ++ + QLLL GA+VN
Sbjct: 10 PPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNA 69
Query: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294
+TPLH A+ N ++ LLL A + + K TPLH AA N + +E L
Sbjct: 70 KDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPL 129
Query: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354
+ + ++G S +H A HL+ V LLL A ++ PLH AA GH V
Sbjct: 130 LSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVL 189
Query: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414
K+L+ +GA + G+ LH A + V++ LL+ GA ID G T LH+A ++
Sbjct: 190 KLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYL 249
Query: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA-KYLLQNKAKVNAKAKDDQTP 473
G + L+ GA+ N N K TPLH+AA + + + + L+ N A VN ++K+ ++P
Sbjct: 250 GQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSP 309
Query: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
LH AA G ++L++N + + A G+TPLH+AAR GH + L+ A A
Sbjct: 310 LHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRG 369
Query: 534 KKGFTPLHVAAKYGKVRVAELLLE-----------RDAHPNAAGKN-------GLTPLHV 575
PLH+A +G LL + H +AG + G T LH
Sbjct: 370 IHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHA 429
Query: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
A N++ + LLL G G TPLH AA + A +L+ G N +G
Sbjct: 430 AASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKG 489
Query: 636 VTPLHLAA-------QEGHAE---------------------MVALLLSKQANGNLGNKS 667
+PLH AA E H + LL A+ +L ++
Sbjct: 490 CSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQ 549
Query: 668 GLT-----------------------------------PLHLVAQEGHVPVADVLIKHGV 692
G T PLHL A GH L + V
Sbjct: 550 GYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLV 609
Query: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK-TKLGYSPLHQAAQQGHTDIVT 751
+D G T L +A+ G+ + V+ L H A K K ++PLH AA GHTD +
Sbjct: 610 NLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLH 669
Query: 752 LLLKNGAS---PNEVSSDGTTPLAIAKRLGYISVTDVL 786
LL+ +G + + + G TPL +A G++ +L
Sbjct: 670 LLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLL 707
Score = 246 bits (627), Expect = 2e-64
Identities = 201/686 (29%), Positives = 299/686 (43%), Gaps = 54/686 (7%)
Query: 201 VLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 260
+LS T PL A ++ + LL++ ++N Q TPLH A+ G+V +++LLL
Sbjct: 3 ILSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLM 62
Query: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
GA + K LTPLH AA + + ++ +LL H A + A+ K +P+H+AA C
Sbjct: 63 SGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKC 122
Query: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380
L + ++ + LH A H GH +LL+KGA N PLH A
Sbjct: 123 AEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAF 182
Query: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440
H+ V++LL+ GA + G LH A+ G + +VK LL+ GA + N T
Sbjct: 183 LGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTA 242
Query: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA-RIGHTNMVKLLLENNANPNLA 499
LH+A G VA L+ A VN TPLH AA ++LL+ N A+ N
Sbjct: 243 LHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQ 302
Query: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 559
+ G +PLH+AA G L++ + C K G TPLHVAA+YG + L+
Sbjct: 303 SKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNG 362
Query: 560 AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG---------GSPH---------SPAWN 601
A G + + PLH+AV D + LL G + H +P
Sbjct: 363 ADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNL 422
Query: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
G T LH AA VE LL G G TPLH AA G + L++ A
Sbjct: 423 GRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGV 482
Query: 662 NLGNKSGLTPLHLVA-------QEGHVPVA---------------------DVLIKHGVM 693
N + G +PLH A E H P + + L+ +G
Sbjct: 483 NEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGAD 542
Query: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV--NAKTKLGYSPLHQAAQQGHTDIVT 751
R GYT +H A+ YGN + ++ LL+ + + ++ + SPLH AA GH + +
Sbjct: 543 PSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALK 602
Query: 752 LLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVD 811
L + + + G T L +A G T+ ++V+T + L+ ++ R P +
Sbjct: 603 TLAETLVNLDVRDHKGRTALFLATERG---STECVEVLTAHGASALIKERKRKWTP--LH 657
Query: 812 EILDVSEDEGEELISFKAERRDSRDV 837
+ L+ ER D DV
Sbjct: 658 AAAASGHTDSLHLLIDSGERADITDV 683
Score = 197 bits (501), Expect = 8e-50
Identities = 182/627 (29%), Positives = 269/627 (42%), Gaps = 32/627 (5%)
Query: 22 SGNLDKALDHLRN------GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT 75
SG L + L N G DINT + G LH A+ G+V+ + LL L
Sbjct: 394 SGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRD 453
Query: 76 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135
K G T LH AA G + LV GA VN KG +PL+ AA + + +
Sbjct: 454 KFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE---PHTP 510
Query: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARNDDTRTAAV 191
+ + A ED PL + ++ + L++ G +R A+H AA + + +
Sbjct: 511 SSHDAEED--EPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLEL 568
Query: 192 LLQNDPN--PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
LL+ N DV S +PLH+AA+ + + L +++ G T L +A+ R
Sbjct: 569 LLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATER 628
Query: 250 GNVIMVRLLLDRGAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQ---AKTKNG 305
G+ V +L GA K K + TPLH AA +GH +L+D G G
Sbjct: 629 GSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYG 688
Query: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
+P+ +A H+DCV LLL+ + D L T LH A G LLD A
Sbjct: 689 QTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVL 748
Query: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASID----AVTESGLTPLHVASFMGHLPIVK 421
R G TP+H+A H V+ LL+ S D V SG +P+H AS+ GH ++
Sbjct: 749 CRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLE 808
Query: 422 NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK--VNAKAKDDQTPLHCAAR 479
LL+ + TPLH A + LL VN++ +TPLH AA
Sbjct: 809 LLLEHSPFSYLEGNPF-TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAF 867
Query: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK-EASQACMTKKGFT 538
+ + +++LL++ A N G T L AA G V LL + +A + + T
Sbjct: 868 ADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNT 927
Query: 539 PLHVAAKYGKVRVAELLLERDAHP---NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
LH+A G + A ++L NA PLH+A + +V+ LL G +
Sbjct: 928 ALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATV 987
Query: 596 HSPAWNGYTPLHIAAKQNQVEVARSLL 622
+ G+TP A V +L+
Sbjct: 988 LAVDEEGHTPALACAPNKDVADCLALI 1014
Score = 48.9 bits (115), Expect = 5e-05
Identities = 35/111 (31%), Positives = 55/111 (49%), Gaps = 6/111 (5%)
Query: 14 TSFLRAARSGNLDKALDHL--RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI-- 69
T+ + AA +G A++ L R D+ ++N LHLA +GH K + +L +
Sbjct: 893 TALMTAAENGQT-AAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDL 951
Query: 70 -ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 119
++ T LHIAA G VV+ L+++GA V A ++G TP A
Sbjct: 952 GLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACA 1002
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 296 bits (758), Expect = 1e-79
Identities = 240/783 (30%), Positives = 356/783 (45%), Gaps = 103/783 (13%)
Query: 89 GQDEVVRELVNYGANVNAQSQKG--FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFT 146
G E V+ LV VN++ G TPL+ AA +VV++LL+NGAN + G
Sbjct: 35 GDVERVKRLVT-PEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLI 93
Query: 147 PLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPDVL 202
PL A GH VV L+ +G R LH AA VLLQ+ P +
Sbjct: 94 PLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIR 153
Query: 203 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVI-MVRLLLDR 261
+ G T L +A + A T + L ++R GN M+ LL
Sbjct: 154 NTDGRTALDLA-------------DPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPL 200
Query: 262 GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV 321
+ TPLH AA V+I ++LL HGA + AK K L P+H A H +
Sbjct: 201 NVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVT 260
Query: 322 RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKK 381
LL+++ A ++ + L TPLH AA V +LL GA P + + + +A
Sbjct: 261 ELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTP 320
Query: 382 NHVRVMELLLKTGASIDAVTESGLT---------------------PLHVAS---FMGHL 417
+ K + + A E+ +T LH A+ +
Sbjct: 321 QLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRK 380
Query: 418 PIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477
I + LL++GA+ N + TPLH+A+ H +V + +++++AKVNA QT LH A
Sbjct: 381 QICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRA 440
Query: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPLHI--------------------------AA 511
A GH +LLL +PN+ + G T L + AA
Sbjct: 441 AYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAA 500
Query: 512 REGHVETVLALLEKEASQACMTKKG--FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569
+ G VETV L + S C +G TPLH AA Y +V V E LL+ A +A K G
Sbjct: 501 KAGDVETVKKLCTVQ-SVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGG 559
Query: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
L PLH A + + ++ +LL+ G + +TPLH AA + + E+ + LLQ+G
Sbjct: 560 LVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPT 619
Query: 630 AESVQGVTPLHLAAQEGHAEMVALL--------------------LSKQANGNLGNKSGL 669
++ G TPL L ++G ++ LL LS N N + G
Sbjct: 620 KKNRDGNTPLDLV-KDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGR 678
Query: 670 --TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727
TPLHL A ++ VA+ L++HG V+A + G PLH A+ YG++ + L+++ A V
Sbjct: 679 HSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACV 738
Query: 728 NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
NA K ++PLH+AAQ+G T + LLL +GA P + +G TPL + +S DV
Sbjct: 739 NATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDL------VSADDVSA 792
Query: 788 VVT 790
++T
Sbjct: 793 LLT 795
Score = 281 bits (718), Expect = 6e-75
Identities = 236/774 (30%), Positives = 348/774 (44%), Gaps = 87/774 (11%)
Query: 12 AATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELLHKEI 69
AA A R+G++++ + L +N+ + G LH A+ G +V LL
Sbjct: 24 AARELFEACRNGDVER-VKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGA 82
Query: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129
++ G LH A G EVV L+ +GA+ NA+ +TPL+ AA + ++V
Sbjct: 83 NVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIV 142
Query: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 189
LL++GA + DG T L +A + A + G K L L A ++ +
Sbjct: 143 LLQHGAEPTIRNTDGRTALDLA------DPSAKAVLTGEYKKDEL--LESARSGNEEKMM 194
Query: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
A+L + N TPLH+AA Y + + QLLL GA V+ + + PLH A
Sbjct: 195 ALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSY 254
Query: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309
G+ + LL+ GA + + TPLH AA V + +LL +GA + S I
Sbjct: 255 GHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAI 314
Query: 310 HMAAQGDHLDCV------RLLLQYDAEID------DITLD---------HLTPLHVAA-- 346
+A + + LLQ E D ++L+ H T LH AA
Sbjct: 315 DLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAAS 374
Query: 347 -HCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 405
+ ++ ++LL KGA N + TPLH+A +K H V+E+++K A ++A+ G
Sbjct: 375 PYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQ 434
Query: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM---------------------- 443
T LH A++ GHL + LL G PN+ +++ T L M
Sbjct: 435 TSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADR 494
Query: 444 ----AARAGHTEVAKYLLQNKAKVNAKAKD--DQTPLHCAARIGHTNMVKLLLENNANPN 497
AA+AG E K L ++ VN + + TPLH AA ++V+ LL++ A+ +
Sbjct: 495 QLLEAAKAGDVETVKKLCTVQS-VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVH 553
Query: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557
G PLH A GH E L++ A FTPLH AA GK + +LLL+
Sbjct: 554 AKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQ 613
Query: 558 RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL--------------LPRGGSPHSP----- 598
A P ++G TPL + V + DI LL L R SP
Sbjct: 614 HGADPTKKNRDGNTPLDL-VKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNC 672
Query: 599 ---AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
TPLH+AA N +EVA LLQ+G NA+ G+ PLH AA GH ++ ALL+
Sbjct: 673 RDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLI 732
Query: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
A N +K TPLH AQ+G + +L+ HG + G TPL + S
Sbjct: 733 KYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVS 786
Score = 229 bits (583), Expect = 2e-59
Identities = 204/644 (31%), Positives = 289/644 (44%), Gaps = 81/644 (12%)
Query: 246 ASRRGNVIMV-RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
A R G+V V RL+ + TPLH AA G + E LL +GA +QA+
Sbjct: 31 ACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDG 90
Query: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364
GL P+H A H + V LLL++ A+ + + TPLH AA G V VLL GA+P
Sbjct: 91 GLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEP 150
Query: 365 NSRALNGFTPLHIA-----------CKK----------NHVRVMELLLKTGASIDAVTES 403
R +G T L +A KK N ++M LL + A
Sbjct: 151 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGR 210
Query: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463
TPLH+A+ + IV+ LLQ GA + + PLH A GH EV + L+++ A V
Sbjct: 211 KSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACV 270
Query: 464 NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT---------------------- 501
NA TPLH AA + LLL A+P L
Sbjct: 271 NAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEF 330
Query: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA--KYGK-VRVAELLLER 558
GH+ L AARE V + L E + T LH AA Y K ++ ELLL +
Sbjct: 331 KGHSLLQ-AAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRK 389
Query: 559 DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 618
A+ N K LTPLHVA + D+V++++ ++ G T LH AA ++
Sbjct: 390 GANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTC 449
Query: 619 RSLLQYGGSANAESVQGVTPLHL--------------------------AAQEGHAEMVA 652
R LL YG N S+QG T L + AA+ G E V
Sbjct: 450 RLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVK 509
Query: 653 LLLSKQANGNLGNKSG--LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASH 710
L + Q + N + G TPLH A V V + L++HG V A + G PLH A
Sbjct: 510 KLCTVQ-SVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACS 568
Query: 711 YGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 770
YG+ ++ + L++H A VN ++PLH+AA +G +I LLL++GA P + + DG TP
Sbjct: 569 YGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTP 628
Query: 771 LAIAKRLGYISVTDVLK---VVTDETSFVLVSDKHRMSFPETVD 811
L + K G + D+L+ + D ++ ++S P+ V+
Sbjct: 629 LDLVKD-GDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVN 671
Score = 191 bits (486), Expect = 4e-48
Identities = 173/584 (29%), Positives = 256/584 (43%), Gaps = 92/584 (15%)
Query: 32 LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 91
L++G D++ ++ L LH A GH ++ L+ + T LH AA +
Sbjct: 231 LQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRV 290
Query: 92 EVVRELVNYGAN---VNAQSQKGF----TP--------------LYMAAQENH------- 123
EV L++YGA+ +N ++ TP L AA+E
Sbjct: 291 EVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKH 350
Query: 124 --LEVVKF---------------------------LLENGANQNVATEDGFTPLAVALQQ 154
LE+V F LL GAN N T++ TPL VA ++
Sbjct: 351 LSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEK 410
Query: 155 GHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPL 210
H +VV ++ + K + +LH AA +T +LL +P+++S GFT L
Sbjct: 411 AHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTAL 470
Query: 211 HIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD-RGAQIETKT 269
+ N NV QLL G S+ + + L A++ G+V V+ L +
Sbjct: 471 QMG----NENVQQLL-QEGISLGNSEAD--RQLLEAAKAGDVETVKKLCTVQSVNCRDIE 523
Query: 270 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 329
+ TPLH AA V + E LL HGA + AK K GL P+H A H + LL+++ A
Sbjct: 524 GRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGA 583
Query: 330 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMEL 389
++ L TPLH AA G + + K+LL GA P + +G TPL + K + +L
Sbjct: 584 VVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV-KDGDTDIQDL 642
Query: 390 LLKTGASIDAVTESGL----------------------TPLHVASFMGHLPIVKNLLQRG 427
L A +DA + L TPLH+A+ +L + + LLQ G
Sbjct: 643 LRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHG 702
Query: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487
A N + PLH AA GH +VA L++ A VNA K TPLH AA+ G T +
Sbjct: 703 ADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCA 762
Query: 488 LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC 531
LLL + A+P L G TPL + + + + A + A +C
Sbjct: 763 LLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPSC 806
Score = 129 bits (325), Expect = 2e-29
Identities = 101/318 (31%), Positives = 150/318 (47%), Gaps = 19/318 (5%)
Query: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG-----LHLASKEGHV 58
S+G EAD L AA++G+++ ++ + + N + G LH A+ V
Sbjct: 486 SLGNSEADR--QLLEAAKAGDVET----VKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRV 539
Query: 59 KMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 118
+V LL + K G LH A G EV LV +GA VN FTPL+ A
Sbjct: 540 SVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEA 599
Query: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH 178
A + E+ K LL++GA+ DG TPL + ++ G ++ L +G L L
Sbjct: 600 AAKGKYEICKLLLQHGADPTKKNRDGNTPLDL-VKDGDTDIQDLL-----RGDAAL--LD 651
Query: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
A + R + ++ N TPLH+AA Y NL VA+ LL GA VN +
Sbjct: 652 AAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKG 711
Query: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
G+ PLH A+ G+V + LL+ A + K TPLH AA+ G ++ +LL HGA
Sbjct: 712 GLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP 771
Query: 299 QAKTKNGLSPIHMAAQGD 316
K + G +P+ + + D
Sbjct: 772 TLKNQEGQTPLDLVSADD 789
Score = 90.5 bits (223), Expect = 1e-17
Identities = 57/152 (37%), Positives = 84/152 (55%), Gaps = 6/152 (3%)
Query: 627 SANAESVQ-GVTPLHLAAQEGHAEMVALLLSKQ---ANGNLGNKSGLTPLHLVAQEGHVP 682
SA AE+V+ L A + G E V L++ + + G KS TPLH A G
Sbjct: 15 SAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKS--TPLHFAAGFGRKD 72
Query: 683 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742
V + L+++G V A G PLH A +G+ ++V LL+H AD NA+ Y+PLH+AA
Sbjct: 73 VVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAA 132
Query: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
+G D+ +LL++GA P ++DG T L +A
Sbjct: 133 IKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA 164
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 294 bits (752), Expect = 6e-79
Identities = 235/762 (30%), Positives = 348/762 (45%), Gaps = 97/762 (12%)
Query: 94 VRELVNYGANVNAQSQKG--FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151
V+ LV+ ANVNA+ G +PL+ AA +VV+ LL+ GAN + + G PL A
Sbjct: 198 VKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNA 256
Query: 152 LQQGHENVVAHLINYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGF 207
GH VV+ L+ G R LH AA VLLQ+ +P++ + G
Sbjct: 257 CSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGK 316
Query: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVI-MVRLLLDRGAQIE 266
+ L +A + A T + L A+R GN ++ LL
Sbjct: 317 SALDLA-------------DPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCH 363
Query: 267 TKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 326
+ TPLH AA VRI ++LL HGA + AK K GL P+H A H + LLL+
Sbjct: 364 ASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLK 423
Query: 327 YDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 386
+ A ++ + L TPLH AA V +LL GA P +G + + +A
Sbjct: 424 HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRER 483
Query: 387 MELLLKTGASIDAVTESGL---------------------TPLHVASFMGH---LPIVKN 422
+ K + + A E+ L T LH A H + +
Sbjct: 484 LTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTEL 543
Query: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482
LL++GA+ N N TPLH+AA H +V + L ++ AK+NA QT LH AA GH
Sbjct: 544 LLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGH 603
Query: 483 TNMVKLLLENNANPNLATTAGHTPLHI--------------------------AAREGHV 516
+LLL ++P++ + G T + A++ G +
Sbjct: 604 LQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDL 663
Query: 517 ETVLALLEKEASQACMTKKG--FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH 574
ETV L + + C +G TPLH AA Y +V V E LL A +A K GL PLH
Sbjct: 664 ETVKQLCSSQ-NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLH 722
Query: 575 VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ 634
A + + ++ +LL+ G S + +TPLH AA + + E+ + LL++G ++
Sbjct: 723 NACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRD 782
Query: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL----------------------TPL 672
G TPL L +EG ++ LL A + K L TPL
Sbjct: 783 GNTPLDLV-KEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPL 841
Query: 673 HLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTK 732
HL A ++ VA+ L++HG V+A + G PLH A+ YG++ + L+++ VNA K
Sbjct: 842 HLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDK 901
Query: 733 LGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
++PLH+AAQ+G T + LLL +GA P + +G TPL +A
Sbjct: 902 WAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 943
Score = 290 bits (742), Expect = 9e-78
Identities = 236/774 (30%), Positives = 347/774 (44%), Gaps = 87/774 (11%)
Query: 12 AATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELLHKEI 69
A L A R+G++ + + L + ++N + G LH A+ G +V LL
Sbjct: 182 ALRELLEACRNGDVSR-VKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGA 240
Query: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129
+ G LH A G EVV L+ GA+ NA+ +TPL+ AA + ++V
Sbjct: 241 NVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIV 300
Query: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 189
LL++GA+ N+ DG + L +A + A + G K L L A ++ +
Sbjct: 301 LLQHGADPNIRNTDGKSALDLA------DPSAKAVLTGEYKKDEL--LEAARSGNEEKLM 352
Query: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
A+L + N TPLH+AA Y + + QLLL GA V+ + G+ PLH A
Sbjct: 353 ALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSY 412
Query: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309
G+ + LLL GA + + TPLH AA V + +LL HGA +G S +
Sbjct: 413 GHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAV 472
Query: 310 HMAAQGDHLDCVRL------LLQYDAEID------DITLD---------HLTPLHVAA-- 346
MA + + + LLQ E D + L+ H T LH A
Sbjct: 473 DMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVAS 532
Query: 347 -HCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 405
H +V ++LL KGA N + + TPLH+A ++ H VME+L K GA ++A+ G
Sbjct: 533 LHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQ 592
Query: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM---------------------- 443
T LH A+ GHL + LL G+ P++ +++ T M
Sbjct: 593 TALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDY 652
Query: 444 ----AARAGHTEVAKYLLQNKAKVNAKAKDDQ--TPLHCAARIGHTNMVKLLLENNANPN 497
A++AG E K L ++ VN + + + TPLH AA ++V+ LL + A+ +
Sbjct: 653 RLLEASKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVH 711
Query: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557
G PLH A GH E L+ AS FTPLH AA GK + +LLL+
Sbjct: 712 AKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLK 771
Query: 558 RDAHPNAAGKNGLTPLHVAVHHNNLDIV----------------------KLLLPRGGSP 595
A P ++G TPL + V + DI KL P +
Sbjct: 772 HGADPTKKNRDGNTPLDL-VKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINC 830
Query: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
TPLH+AA N +EVA LL++G NA+ G+ PLH AA GH ++ ALL+
Sbjct: 831 RDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLI 890
Query: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
N +K TPLH AQ+G + +L+ HG + G TPL +A+
Sbjct: 891 KYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLAT 944
Score = 234 bits (596), Expect = 8e-61
Identities = 199/617 (32%), Positives = 279/617 (45%), Gaps = 78/617 (12%)
Query: 246 ASRRGNVIMVRLLLDRGAQIETKTKD--ELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
A R G+V V+ L+D A + K + +PLH AA G + E LL GA + A+
Sbjct: 189 ACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDD 247
Query: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
GL P+H A H + V LLL A+ + + TPLH AA G V VLL GA
Sbjct: 248 GGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAD 307
Query: 364 PNSRALNGFTPLHIA-----------CKK----------NHVRVMELLLKTGASIDAVTE 402
PN R +G + L +A KK N ++M LL + A
Sbjct: 308 PNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDG 367
Query: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK 462
TPLH+A+ + IV+ LLQ GA + + PLH A GH EV + LL++ A
Sbjct: 368 RKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGAC 427
Query: 463 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA------------ 510
VNA TPLH AA + LLL + A+P L G + + +A
Sbjct: 428 VNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYE 487
Query: 511 ---------AREGHVETVLALLEKEASQACMTKKGFTPLH--VAAKYGKVR-VAELLLER 558
ARE + V L E + T LH VA+ + K + V ELLL +
Sbjct: 488 FKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRK 547
Query: 559 DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 618
A+ N K+ +TPLHVA + D++++L G ++ G T LH AA ++
Sbjct: 548 GANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTC 607
Query: 619 RSLLQYGGSANAESVQGVTPLHL--------------------------AAQEGHAEMVA 652
R LL YG + S+QG T + A++ G E V
Sbjct: 608 RLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVK 667
Query: 653 LLLSKQANGNLGNKSGL--TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASH 710
L S Q N N + G TPLH A V V + L+ HG V A + G PLH A
Sbjct: 668 QLCSSQ-NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACS 726
Query: 711 YGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 770
YG+ ++ + L++H A VN ++PLH+AA +G +I LLLK+GA P + + DG TP
Sbjct: 727 YGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTP 786
Query: 771 LAIAKRLGYISVTDVLK 787
L + K G + D+L+
Sbjct: 787 LDLVKE-GDTDIQDLLR 802
Score = 191 bits (485), Expect = 6e-48
Identities = 170/588 (28%), Positives = 250/588 (42%), Gaps = 100/588 (17%)
Query: 32 LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 91
L++G D++ ++ GL LH A GH ++ LL + T LH AA +
Sbjct: 389 LQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRV 448
Query: 92 EVVRELVNYGA-----NVNAQSQKGFTP----------------LYMAAQENHL------ 124
EV L+++GA N + +S P L AA+E L
Sbjct: 449 EVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKT 508
Query: 125 ------------------------------EVVKFLLENGANQNVATEDGFTPLAVALQQ 154
+V + LL GAN N +D TPL VA ++
Sbjct: 509 LALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAER 568
Query: 155 GHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPL 210
H +V+ L +G K + ALH AA +T +LL +P ++S GFT
Sbjct: 569 AHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT-- 626
Query: 211 HIAAHYENLNVAQLLLN----RGASVNFTPQNGITPLHIASRRGNVIMVRLLLD-RGAQI 265
AA N V Q+L R + V++ L AS+ G++ V+ L +
Sbjct: 627 --AAQMGNEAVQQILSESTPIRTSDVDYR-------LLEASKAGDLETVKQLCSSQNVNC 677
Query: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLL 325
TPLH AA V + E LL HGA + AK K GL P+H A H + LL+
Sbjct: 678 RDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLV 737
Query: 326 QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR 385
++ A ++ L TPLH AA G + + K+LL GA P + +G TPL + K+
Sbjct: 738 RHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLV-KEGDTD 796
Query: 386 VMELLLKTGASIDAVTESGL----------------------TPLHVASFMGHLPIVKNL 423
+ +LL A +DA + L TPLH+A+ +L + + L
Sbjct: 797 IQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYL 856
Query: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
L+ GA N + PLH AA GH ++A L++ VNA K TPLH AA+ G T
Sbjct: 857 LEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRT 916
Query: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC 531
+ LLL + A+P + G TPL +A + ++ + EA C
Sbjct: 917 QLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTC 964
Score = 154 bits (389), Expect = 8e-37
Identities = 130/450 (28%), Positives = 200/450 (44%), Gaps = 49/450 (10%)
Query: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNV--KVETPLHMAARAGHTE 451
G + AV+ L L A G + VK L+ A+ N ++ + +PLH AA G +
Sbjct: 173 GTGVPAVS-GALRELLEACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKD 230
Query: 452 VAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAA 511
V ++LLQ A V+A+ PLH A GH +V LLL A+PN +TPLH AA
Sbjct: 231 VVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAA 290
Query: 512 REGHVETVLALLEKEASQACMTKKGFTPLHVA---------AKYGKVRVAE--------- 553
+G ++ + LL+ A G + L +A +Y K + E
Sbjct: 291 IKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEK 350
Query: 554 ---LLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAA 610
LL + + +A+ TPLH+A +N + IV+LLL G H+ G PLH A
Sbjct: 351 LMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNAC 410
Query: 611 KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLT 670
EV LL++G NA + TPLH AA + E+ +LLLS A+ L N G +
Sbjct: 411 SYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKS 470
Query: 671 PLHLV---------------------AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
+ + A+E + + ++ + T LH A
Sbjct: 471 AVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAV 530
Query: 710 ---HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766
H ++ + LL+ A+VN K K +PLH AA++ H D++ +L K+GA N + +
Sbjct: 531 ASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTL 590
Query: 767 GTTPLAIAKRLGYISVTDVLKVVTDETSFV 796
G T L A G++ +L + S +
Sbjct: 591 GQTALHRAALAGHLQTCRLLLSYGSDPSII 620
Score = 137 bits (346), Expect = 8e-32
Identities = 101/315 (32%), Positives = 151/315 (47%), Gaps = 11/315 (3%)
Query: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMV 61
S R +D L A+++G+L+ + L + ++N + G + LH A+ V +V
Sbjct: 642 STPIRTSDVDYRLLEASKAGDLE-TVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVV 700
Query: 62 VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
LLH + K G LH A G EV LV +GA+VN FTPL+ AA +
Sbjct: 701 EYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAK 760
Query: 122 NHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAA 181
E+ K LL++GA+ DG TPL + +++G ++ L +G L L A
Sbjct: 761 GKYEICKLLLKHGADPTKKNRDGNTPLDL-VKEGDTDIQDLL-----RGDAAL--LDAAK 812
Query: 182 RNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGIT 241
+ R + + N TPLH+AA Y NL VA+ LL GA VN + G+
Sbjct: 813 KGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLI 872
Query: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301
PLH A+ G+V + LL+ + K TPLH AA+ G ++ +LL HGA K
Sbjct: 873 PLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMK 932
Query: 302 TKNGLSPIHMAAQGD 316
+ G +P+ +A D
Sbjct: 933 NQEGQTPLDLATADD 947
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 235 bits (599), Expect = 3e-61
Identities = 145/398 (36%), Positives = 214/398 (53%), Gaps = 2/398 (0%)
Query: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
TPLH ++ +LLL V+ +G TPL IA++ + LLL GA
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
Query: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 327
+D PLH AA+NG + +LLDHGA + A+ + G +P+H+AAQ + + RLL+
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483
Query: 328 DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387
A+ + + TPLHVAA+ GH + K+L +GA+ +++ N TPLH+A ++ VR +
Sbjct: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAI 543
Query: 388 ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 447
+ LLK+GA DA+ +SG PLH A+ G I K LL+ GAS + + TPLH+AA
Sbjct: 544 QHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYK 603
Query: 448 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 507
GH E+ L ++ A + A + TPLH AAR G +V LL+ A+PN A +G TPL
Sbjct: 604 GHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPL 663
Query: 508 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 567
H+A + +V+ LLE A+ K G+TP H+AA G + ++L+E A +
Sbjct: 664 HLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDG 723
Query: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTP 605
TPL +A+ I+ L G P G P
Sbjct: 724 VSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
Score = 231 bits (590), Expect = 4e-60
Identities = 134/389 (34%), Positives = 208/389 (53%)
Query: 270 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 329
++++TPLH G V +LL H + +T +G +P+ +AAQ D LLL + A
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
Query: 330 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMEL 389
+ + + D PLH AA G A++LLD GA +++ G+TPLH+A + N V L
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
Query: 390 LLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGH 449
L+ A + G TPLHVA++ GH+ +VK L +GA + + TPLH+A G
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
Query: 450 TEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509
++LL++ A +A + PLH AA G + K+LL A+ L T G TPLH+
Sbjct: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
Query: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569
AA +GH+E + L E A+ + +TPLH+AA++G+ V LL+ A PNAA ++G
Sbjct: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
Query: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
TPLH+AV + V LL + H+ G+TP H+AA + + + L++ G +
Sbjct: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
Query: 630 AESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
+ TPL LA + +++ L K+
Sbjct: 720 VQDGVSCTPLQLALRSRKQGIMSFLEGKE 748
Score = 223 bits (569), Expect = 1e-57
Identities = 140/401 (34%), Positives = 204/401 (50%), Gaps = 2/401 (0%)
Query: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429
N TPLH + V + LLL +D T SG TPL +A+ + LL GA
Sbjct: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
Query: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489
N + PLH AA+ G A+ LL + A V+A+ ++ TPLH AA+ N+ +LL
Sbjct: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
Query: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549
+ A+PNL G TPLH+AA GHV V L + A + TPLH+A + GKV
Sbjct: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540
Query: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 609
R + LL+ A P+A ++G PLH A I K+LL G S P G+TPLH+A
Sbjct: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600
Query: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
A + +E+ L + + A TPLHLAA+ G +V+ LL A+ N +SG
Sbjct: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660
Query: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
TPLHL Q L++H V A ++G+TP H+A+ GN ++K L++ A ++
Sbjct: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720
Query: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 770
+ + +PL A + I++ L G P+ + G+ P
Sbjct: 721 QDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
Score = 218 bits (556), Expect = 3e-56
Identities = 132/377 (35%), Positives = 198/377 (52%)
Query: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 459
+ E+ +TPLH G + V+ LL + TPL +AA+ ++ LL +
Sbjct: 358 IYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417
Query: 460 KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519
A N +D PLH AA+ G +LLL++ A + G TPLH+AA+
Sbjct: 418 GADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVA 477
Query: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHH 579
L+ ++A +G TPLHVAA +G V + +LL + A +A +N TPLH+AV
Sbjct: 478 RLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVER 537
Query: 580 NNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPL 639
+ ++ LL G P + +GY PLH AA + + + + LL+YG S + QG TPL
Sbjct: 538 GKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPL 597
Query: 640 HLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTR 699
HLAA +GH E++ LL AN TPLHL A+ G V L++ G +A +
Sbjct: 598 HLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQ 657
Query: 700 MGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGAS 759
G+TPLH+A V LL+H A+V+A+ K+G++P H AA +G+T I+ +L++ GA
Sbjct: 658 SGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQ 717
Query: 760 PNEVSSDGTTPLAIAKR 776
+ TPL +A R
Sbjct: 718 LDVQDGVSCTPLQLALR 734
Score = 217 bits (553), Expect = 8e-56
Identities = 134/378 (35%), Positives = 193/378 (51%)
Query: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296
+N +TPLH +G+V VRLLL ++ +T TPL AA++ + +LL HGA
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
Query: 297 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 356
++G +P+H AAQ RLLL + A +D + TPLH+AA VA++
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
Query: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416
L+ + A PN G TPLH+A HV +++LL GA +DA + TPLH+A G
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
Query: 417 LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 476
+ +++LL+ GA P+ + PLH AA G + K LL+ A + TPLH
Sbjct: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
Query: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
AA GH ++ LL E++AN TPLH+AAR G V ALL+ A + G
Sbjct: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
Query: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
+TPLH+A + LLE A+ +A K G TP H+A N I+K+L+ G
Sbjct: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
Query: 597 SPAWNGYTPLHIAAKQNQ 614
TPL +A + +
Sbjct: 720 VQDGVSCTPLQLALRSRK 737
Score = 214 bits (545), Expect = 6e-55
Identities = 133/400 (33%), Positives = 203/400 (50%), Gaps = 2/400 (0%)
Query: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232
++ LH +LL ++ + D + +G+TPL IAA + ++ LLL GA
Sbjct: 362 KVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADA 421
Query: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
N ++G PLH A++ G+ RLLLD GA ++ + ++ TPLH AA+N ++ +L+
Sbjct: 422 NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLV 481
Query: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352
A G +P+H+AA H+ V+LL AE+D + TPLH+A G R
Sbjct: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVR 541
Query: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 412
+ LL GA P++ +G+ PLH A + + ++LL+ GAS++ T G TPLH+A+
Sbjct: 542 AIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAA 601
Query: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQT 472
+ GHL I+ L + A+ TPLH+AAR G V LLQ A NA + T
Sbjct: 602 YKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWT 661
Query: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532
PLH A + V LLE++AN + G TP H+AA +G+ + L+E A
Sbjct: 662 PLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721
Query: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTP 572
TPL +A + K + L ++ P+ A G P
Sbjct: 722 DGVSCTPLQLALRSRKQGIMSFLEGKE--PSVATLGGSKP 759
Score = 211 bits (537), Expect = 5e-54
Identities = 125/372 (33%), Positives = 197/372 (52%)
Query: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
+N ++P+H ++ VRLLL ++ ++D T TPL +AA + +LL GA
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
Query: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422
N +G+ PLH A + LLL GA +DA G TPLH+A+ + +
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
Query: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482
L+ R A PN+ + +TPLH+AA GH + K L A+++A+ ++ +TPLH A G
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
Query: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542
++ LL++ A P+ +G+ PLH AA G LL AS T +G+TPLH+
Sbjct: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
Query: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
AA G + + LL E A+ A G TPLH+A H +V LL G P++ +G
Sbjct: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
Query: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
+TPLH+A +++ +LL++ + +A + G TP HLAA +G+ ++ +L+ A +
Sbjct: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
Query: 663 LGNKSGLTPLHL 674
+ + TPL L
Sbjct: 720 VQDGVSCTPLQL 731
Score = 208 bits (530), Expect = 3e-53
Identities = 131/414 (31%), Positives = 215/414 (51%), Gaps = 29/414 (7%)
Query: 43 QNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGA 102
+N + LH +G V+ V LL E+ ++ T G T L IAA Q ++ L+ +GA
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
Query: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 162
+ N + G+ PL+ AAQ + LL++GA + +G+TPL +A Q ENV
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENV--- 476
Query: 163 LINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA 222
A +L+ +P++ G TPLH+AA++ ++++
Sbjct: 477 --------------------------ARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLV 510
Query: 223 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282
+LL ++GA ++ +N TPLH+A RG V ++ LL GA + + PLH AA
Sbjct: 511 KLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAAR 570
Query: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342
G I ++LL +GA ++ T G +P+H+AA HL+ + LL + A + + + TPL
Sbjct: 571 GKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPL 630
Query: 343 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE 402
H+AA G V LL GA PN+ +G+TPLH+A +++ + LL+ A++ A +
Sbjct: 631 HLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNK 690
Query: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
G TP H+A+ G+ I+K L++ GA +V + TPL +A R+ + +L
Sbjct: 691 VGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744
Score = 197 bits (500), Expect = 1e-49
Identities = 135/421 (32%), Positives = 212/421 (50%), Gaps = 31/421 (7%)
Query: 113 TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 172
TPL+ + +E V+ LL + + + T G+TPL +A Q ++ A L+ +G
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD--- 420
Query: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232
A R D+ G+ PLH AA + A+LLL+ GA V
Sbjct: 421 -------ANRVDED-------------------GWAPLHFAAQNGDDGTARLLLDHGACV 454
Query: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
+ + G TPLH+A++ + RLL+ R A + TPLH AA GHV + ++L
Sbjct: 455 DAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLT 514
Query: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352
GA + A+ +N +P+H+A + + ++ LL+ A D + PLH AA G +
Sbjct: 515 SQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYL 574
Query: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 412
+ K+LL GA G+TPLH+A K H+ ++ LL ++ A++ A+ TPLH+A+
Sbjct: 575 ICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAA 634
Query: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQT 472
G +V LLQ GA PN + TPLH+A + LL++ A V+A+ K T
Sbjct: 635 RHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWT 694
Query: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE-KEASQAC 531
P H AA G+T ++K+L+E A ++ TPL +A R + +++ LE KE S A
Sbjct: 695 PAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALR-SRKQGIMSFLEGKEPSVAT 753
Query: 532 M 532
+
Sbjct: 754 L 754
Score = 196 bits (497), Expect = 2e-49
Identities = 131/380 (34%), Positives = 194/380 (51%), Gaps = 4/380 (1%)
Query: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
KNL+ R + KV TPLH G E + LL ++ V+ + TPL AA+
Sbjct: 347 KNLVPRDEELCIYENKV-TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQD 405
Query: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
++ LLL + A+ N G PLH AA+ G T LL+ A ++G+TPL
Sbjct: 406 QQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPL 465
Query: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600
H+AA+ VA LL+ R A PN G TPLHVA + ++ +VKLL +G +
Sbjct: 466 HLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQR 525
Query: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
N TPLH+A ++ +V + LL+ G +A G PLH AA G + +LL A+
Sbjct: 526 NLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGAS 585
Query: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
L G TPLHL A +GH+ + +L + + A + +TPLH+A+ +G +V L
Sbjct: 586 LELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645
Query: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780
LQ AD NA + G++PLH A Q+ V LL++ A+ + + G TP +A G
Sbjct: 646 LQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGN- 704
Query: 781 SVTDVLKVVTDETSFVLVSD 800
T +LKV+ + + + V D
Sbjct: 705 --TAILKVLVEAGAQLDVQD 722
Score = 175 bits (443), Expect = 4e-43
Identities = 117/373 (31%), Positives = 190/373 (50%), Gaps = 6/373 (1%)
Query: 23 GNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTAL 82
G++++ L + VD++ +G L +A+++ + LL + G L
Sbjct: 373 GSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPL 432
Query: 83 HIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATE 142
H AA G D R L+++GA V+AQ ++G+TPL++AAQ N V + L+ A+ N+
Sbjct: 433 HFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEA 492
Query: 143 DGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRTAAVLLQNDP 197
+G TPL VA GH ++V L + G + +R P LH+A R LL++
Sbjct: 493 EGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTP-LHLAVERGKVRAIQHLLKSGA 551
Query: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 257
PD L ++G+ PLH AA + ++LL GAS+ G TPLH+A+ +G++ ++ L
Sbjct: 552 VPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHL 611
Query: 258 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH 317
L + A + TPLH AAR+G + LL GA A ++G +P+H+A Q
Sbjct: 612 LAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRST 671
Query: 318 LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377
V LL++ A + TP H+AA G+ + KVL++ GA+ + + TPL +
Sbjct: 672 FLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQL 731
Query: 378 ACKKNHVRVMELL 390
A + +M L
Sbjct: 732 ALRSRKQGIMSFL 744
Score = 119 bits (299), Expect = 2e-26
Identities = 83/300 (27%), Positives = 137/300 (45%), Gaps = 31/300 (10%)
Query: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
EA+ T AA G++ G +++ +N LHLA + G V+ + LL
Sbjct: 491 EAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550
Query: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
+ + + G LH AA G+ + + L+ YGA++ + +G+TPL++AA + HLE++
Sbjct: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610
Query: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRT 188
L E+ AN +TPL +A + G E VV
Sbjct: 611 LLAESHANMGALGAVNWTPLHLAARHGEEAVV---------------------------- 642
Query: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248
+ LLQ +P+ ++G+TPLH+A LL A+V+ + G TP H+A+
Sbjct: 643 -SALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAAL 701
Query: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308
+GN ++++L++ GAQ++ + TPL A R+ I L G T G P
Sbjct: 702 KGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 228 bits (580), Expect = 6e-59
Identities = 202/632 (31%), Positives = 299/632 (47%), Gaps = 51/632 (8%)
Query: 17 LRAARSGNLDKALDHLRNGVDINTCN--QNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
L ++ S LD+A L +T N Q+ L A EG V V +LL + +
Sbjct: 204 LTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEH 263
Query: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG-FTPLYMAAQENHLEVVKFLLEN 133
T++G + L +A AG E+ + L+ ANV + KG TPL AA H+++VK LL +
Sbjct: 264 TEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAH 323
Query: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLL 193
A+ N + G T L A G+ +VV VLL
Sbjct: 324 KADVNAQSSTGNTALTYACAGGYVDVV-----------------------------KVLL 354
Query: 194 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI--TPLHIASRRGN 251
++ + + ++ G TPL A ++ VA+LLL GA +N T N + L +A +G+
Sbjct: 355 ESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN-THSNEFKESALTLACYKGH 413
Query: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 311
+ MVR LL+ GA E KT + T L A +GHV ++ +LLD GA + + SP+ +
Sbjct: 414 LEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 473
Query: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA-LN 370
AA G H++ LL++ A ++++ + TPL AA GH + +LL +GA N++
Sbjct: 474 AACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEET 533
Query: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
T L +AC + V + L+K GA I+ TPL A+ GHL +VK LL GA+
Sbjct: 534 QETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANV 590
Query: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490
+ + +T L A GHT+VA LLQ A + +++ +TPL AAR GH V+ L+
Sbjct: 591 HATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLI 650
Query: 491 ENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549
AN N T HT L +A GH+ V LL A K G T L AAK G
Sbjct: 651 SKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 710
Query: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNN------LDIVKLLLPRGGSPHSPAWNGY 603
V LL+ + +A +T L H N + + +++P P P N
Sbjct: 711 SVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVP-PQEPDKPPANVA 769
Query: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
T L I K + + S L AN++ VQG
Sbjct: 770 TTLPIRNKAASKQKSSSHL----PANSQDVQG 797
Score = 224 bits (571), Expect = 6e-58
Identities = 167/513 (32%), Positives = 257/513 (50%), Gaps = 16/513 (3%)
Query: 255 VRLLLDRGAQIETKTKDELTP---------LHCAARNGHVRISEILLDHGAPIQAKTKNG 305
V LD A T+ + E T L A G V LL G + T+ G
Sbjct: 208 VSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEG 267
Query: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLD-HLTPLHVAAHCGHHRVAKVLLDKGAKP 364
S + +A + + ++LL A ++D + +TPL AA+ GH ++ K+LL A
Sbjct: 268 ESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADV 327
Query: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
N+++ G T L AC +V V+++LL++GASI+ E+G TPL A GH+ + + LL
Sbjct: 328 NAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLL 387
Query: 425 QRGASPNV-SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
+ GA N SN E+ L +A GH E+ ++LL+ A K + T L A GH
Sbjct: 388 ENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 447
Query: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
+ +LLL++ A N+ + +PL +AA GHVE L+E+ AS + +G+TPL A
Sbjct: 448 EVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEA 507
Query: 544 AKYGKVRVAELLLERDAHPNAAGKNGL-TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
A+ G + LLL + A+ NA + T L +A L++ L+ G
Sbjct: 508 AREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGC--- 564
Query: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
TPL AA++ +E+ + LL G + +A + G T L A + GH ++ +LL A+
Sbjct: 565 STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624
Query: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG-YTPLHVASHYGNIKLVKFLL 721
++ G TPL A+ GHV LI G V+ TT +T L +A G++ +V+ LL
Sbjct: 625 HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLL 684
Query: 722 QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
H AD + K G + L +AA+ GHT +V LL
Sbjct: 685 AHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
Score = 221 bits (564), Expect = 4e-57
Identities = 166/474 (35%), Positives = 242/474 (51%), Gaps = 8/474 (1%)
Query: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG- 371
++GD ++ VR LL +++ T + + L +A G++ +A+VLL A R + G
Sbjct: 243 SEGD-VNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGD 301
Query: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
TPL A HV++++LLL A ++A + +G T L A G++ +VK LL+ GAS
Sbjct: 302 ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIE 361
Query: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLL 490
N TPL A AGH EVA+ LL+N A +N + + ++ L A GH MV+ LL
Sbjct: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL 421
Query: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550
E A+ T HT L A +GHVE LL+ A +PL +AA G V
Sbjct: 422 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 481
Query: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY-TPLHIA 609
+A LL+ER A G TPL A + ++V LLL +G + ++ T L +A
Sbjct: 482 LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLA 541
Query: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
+EVA L++ G TPL AAQEGH E+V LL+ AN + +G
Sbjct: 542 CCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGD 598
Query: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
T L + GH VADVL++ G ++ + G TPL A+ G++ V+FL+ A+VN
Sbjct: 599 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658
Query: 730 KT-KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782
T ++ L A GH +V LLL +GA P DG+T L A + G+ SV
Sbjct: 659 TTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSV 712
Score = 219 bits (557), Expect = 3e-56
Identities = 174/509 (34%), Positives = 248/509 (48%), Gaps = 13/509 (2%)
Query: 222 AQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAAR 281
A L R S Q+ L A G+V VR LL G + T++ + L A
Sbjct: 217 AALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACS 276
Query: 282 NGHVRISEILLDHGAPIQAK-TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLT 340
G+ ++++LL A ++ + K ++P+ AA G H+ V+LLL + A+++ + T
Sbjct: 277 AGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNT 336
Query: 341 PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
L A G+ V KVLL+ GA NG TPL A HV V LLL+ GA I+
Sbjct: 337 ALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTH 396
Query: 401 T----ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
+ ES LT +A + GHL +V+ LL+ GA ++ T L A GH EVA+ L
Sbjct: 397 SNEFKESALT---LACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 453
Query: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
L + A+VN A ++PL AA GH + LL+E A+ G+TPL AAREGH
Sbjct: 454 LDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHE 513
Query: 517 ETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 575
E V LL + A+ T++ T L +A G + VA+ L++ A TPL
Sbjct: 514 EMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLME 570
Query: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
A +L++VK LL G + H+ G T L A + +VA LLQ G ES G
Sbjct: 571 AAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 630
Query: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMV 694
TPL AA+ GH V L+SK AN N + T L L GH+ V ++L+ HG
Sbjct: 631 RTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADP 690
Query: 695 DATTRMGYTPLHVASHYGNIKLVKFLLQH 723
+ G T L A+ G+ +V +LL +
Sbjct: 691 THRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
Score = 206 bits (525), Expect = 1e-52
Identities = 178/555 (32%), Positives = 254/555 (45%), Gaps = 38/555 (6%)
Query: 91 DEVVRELVNYGANVNAQS-QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 149
DE L A A + Q L A E + V+ LL G + N TE+G + L
Sbjct: 213 DEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLC 272
Query: 150 VALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 209
+A G+ + L+ A+H + K TP
Sbjct: 273 LACSAGYYELAQVLL-----------AMHANVEDRGI-----------------KGDITP 304
Query: 210 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 269
L AA+ ++ + +LLL A VN G T L A G V +V++LL+ GA IE
Sbjct: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHN 364
Query: 270 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN-GLSPIHMAAQGDHLDCVRLLLQYD 328
++ TPL A GHV ++ +LL++GA I + S + +A HL+ VR LL+
Sbjct: 365 ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAG 424
Query: 329 AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVME 388
A+ + T + T L A GH VA++LLD GA+ N A + +PL +A HV +
Sbjct: 425 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 484
Query: 389 LLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARA 447
LL++ GAS++ V + G TPL A+ GH +V LL +GA+ N + ET L +A
Sbjct: 485 LLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCG 544
Query: 448 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 507
G EVA +L++ A + TPL AA+ GH +VK LL AN + T G T L
Sbjct: 545 GFLEVADFLIKAGADIELGC---STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTAL 601
Query: 508 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN-AAG 566
A GH + LL+ A ++ G TPL AA+ G V + L+ + A+ N
Sbjct: 602 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTA 661
Query: 567 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626
N T L +A +L +V+LLL G P +G T L AAK V LL Y
Sbjct: 662 NNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPN 721
Query: 627 ---SANAESVQGVTP 638
SA V +TP
Sbjct: 722 NLLSAPPPDVTQLTP 736
Score = 205 bits (522), Expect = 3e-52
Identities = 160/485 (32%), Positives = 241/485 (49%), Gaps = 11/485 (2%)
Query: 15 SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
S A G+++ L G +N + G + L LA G+ ++ LL +E
Sbjct: 237 SLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 296
Query: 75 TKKGN-TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
KG+ T L AA G ++V+ L+ + A+VNAQS G T L A +++VVK LLE+
Sbjct: 297 GIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES 356
Query: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRT 188
GA+ E+G TPL A GH V L+ G + + AL +A
Sbjct: 357 GASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEM 416
Query: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248
LL+ + + + T L A ++ VA+LLL+ GA VN + +PL +A+
Sbjct: 417 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 476
Query: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-S 307
G+V + LL++RGA +E + TPL AAR GH + +LL GA I A+T+ +
Sbjct: 477 GGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQET 536
Query: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367
+ +A G L+ L++ A DI L TPL AA GH + K LL GA ++
Sbjct: 537 ALTLACCGGFLEVADFLIKAGA---DIELGCSTPLMEAAQEGHLELVKYLLAAGANVHAT 593
Query: 368 ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427
G T L AC+ H V ++LL+ GA ++ +E G TPL A+ GH+ V+ L+ +G
Sbjct: 594 TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKG 653
Query: 428 ASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486
A+ N + + T L +A GH V + LL + A + KD T L AA+ GHT++V
Sbjct: 654 ANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVV 713
Query: 487 KLLLE 491
LL+
Sbjct: 714 CYLLD 718
Score = 199 bits (506), Expect = 2e-50
Identities = 146/412 (35%), Positives = 209/412 (50%), Gaps = 6/412 (1%)
Query: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
AC + V + LL G S++ TE G + L +A G+ + + LL A+ +K
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
Query: 438 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
+ TPL AA GH ++ K LL +KA VNA++ T L A G+ ++VK+LLE+ A+
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
Query: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 555
GHTPL A GHVE LLE A + + + L +A G + + L
Sbjct: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420
Query: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615
LE A T L A ++++ +LLL G + PA + +PL +AA V
Sbjct: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480
Query: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 674
E+A L++ G S + +G TPL AA+EGH EMVALLL + AN N + T L L
Sbjct: 481 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
Query: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734
G + VAD LIK G ++ TPL A+ G+++LVK+LL A+V+A T G
Sbjct: 541 ACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATG 597
Query: 735 YSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
+ L A + GHTD+ +LL+ GA S G TPL A R G++ L
Sbjct: 598 DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL 649
Score = 196 bits (497), Expect = 2e-49
Identities = 253/996 (25%), Positives = 391/996 (39%), Gaps = 116/996 (11%)
Query: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
E +T + AA+ G+L+ L G +++ G L A + GH + LL
Sbjct: 561 ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAG 620
Query: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVV 127
LE ++ G T L AA AG V+ L++ GANVN + T L +A HL VV
Sbjct: 621 ADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVV 680
Query: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA----------- 176
+ LL +GA+ +DG T L A + GH +VV +L++Y P
Sbjct: 681 ELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHD 740
Query: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN----RGASV 232
L+ A R V+ +P+ + P+ A + + + L N +G
Sbjct: 741 LNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAASKQKSSSHLPANSQDVQGYIT 800
Query: 233 NFTP-------QNGITPLHIASRRG---NVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282
N +P Q +T L + N + L L Q+ + +EL
Sbjct: 801 NQSPESIVEEAQGKLTELEQRIKEAIEKNAQLQSLELAHADQLTKEKIEELNKTREEQIQ 860
Query: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342
+I E L +Q KT+ L ++ + R+ LQ + L LTP+
Sbjct: 861 KKQKILEELQKVERELQLKTQQQLKKQYLEVKAQ-----RIQLQQQQQQSCQHLGLLTPV 915
Query: 343 HVAAHCGHHRVAKV-----LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI 397
V A++ +L K + A GF P+ + + L G SI
Sbjct: 916 GVGEQLSEGDYARLQQVDPVLLKDEPQQTAAQMGFAPIQPLAMPQALPLAAGPLPPG-SI 974
Query: 398 DAVTE-----SGLTPLHVASFMGHLPIVKNLLQRG---ASPNVSNVKVETPLHMAARAGH 449
+TE G L A G + Q+G ASP + MAA +G
Sbjct: 975 ANLTELQGVIVGQPVLGQAQLAGLGQGILTETQQGLMVASP-AQTLNDTLDDIMAAVSGR 1033
Query: 450 TEVAKYLLQNKAKVNAKAKDDQTP---LHCAARIGHTNMVKLLLENNANPNLATTAGHTP 506
+ + TP + +A + + + + +N + A T
Sbjct: 1034 ASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALT----- 1088
Query: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566
+A GH E V LLE+ AS KKGFTPL +AA G V V E+LL+ A A
Sbjct: 1089 --LACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQS 1146
Query: 567 KNGL-TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYG 625
+ TPL +A ++V+LLL RG + + YTPL +AA V + + LL G
Sbjct: 1147 ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 1206
Query: 626 GSANAE--SVQGVTPLHLAAQEGH----------------------------------AE 649
N+ S G++PL LAA GH E
Sbjct: 1207 AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTE 1266
Query: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA--TTRMGYTPLHV 707
+V+LLL ++AN K+GLTPL A G+ V VL+ G V+A T L +
Sbjct: 1267 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1326
Query: 708 ASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767
A+ G+ K + L+ A ++ + K G +PL AA GH D+V LL++ GA + +
Sbjct: 1327 AADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1386
Query: 768 TTPLAIAKRLGYISVTDVL-KVVTDETS-------FVLVSDKHRMS----FPETVDEILD 815
TPL A R G++ V L K V S ++DK + E++ + D
Sbjct: 1387 ITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKD 1446
Query: 816 VSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVES---------PAIPRIPCAM 866
E + S E D + EE L K ++ E + I
Sbjct: 1447 RQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKN 1506
Query: 867 PETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNI 902
E +++ ++++ K DE ++ P+ T+ I
Sbjct: 1507 KENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTI 1542
Score = 184 bits (466), Expect = 9e-46
Identities = 150/464 (32%), Positives = 217/464 (46%), Gaps = 35/464 (7%)
Query: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
T + AA G++ L + D+N + G L A G+V +V LL +E
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
Query: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132
+ G+T L A AG EV R L+ GA +N S + + L +A + HLE+V+FLLE
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
Query: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192
GA+Q T++ T L A GH V L++ G +V +PA
Sbjct: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPA---------------- 464
Query: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252
+ +PL +AA ++ +A LL+ RGAS+ G TPL A+R G+
Sbjct: 465 -----------DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHE 513
Query: 253 IMVRLLLDRGAQIETKTKD-ELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 311
MV LLL +GA I +T++ + T L A G + +++ L+ GA I+ +P+
Sbjct: 514 EMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLME 570
Query: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371
AAQ HL+ V+ LL A + T T L A GH VA VLL GA + G
Sbjct: 571 AAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 630
Query: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVT-ESGLTPLHVASFMGHLPIVKNLLQRGASP 430
TPL A + HV ++ L+ GA+++ T + T L +A GHL +V+ LL GA P
Sbjct: 631 RTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADP 690
Query: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474
T L AA+ GHT V YLL + + D T L
Sbjct: 691 THRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQL 734
Score = 63.9 bits (154), Expect = 1e-09
Identities = 41/131 (31%), Positives = 67/131 (51%), Gaps = 2/131 (1%)
Query: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMV 61
+V R T + AA G + L G D+N + L +A+ +GH K
Sbjct: 1277 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1336
Query: 62 VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
L+ + ++ KKGNT L +AA G +VV+ LV GA+V+A + TPL A ++
Sbjct: 1337 ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRK 1396
Query: 122 NHLEVVKFLLE 132
H++VV++L++
Sbjct: 1397 GHVKVVRYLVK 1407
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 223 bits (569), Expect = 1e-57
Identities = 168/485 (34%), Positives = 243/485 (50%), Gaps = 13/485 (2%)
Query: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308
G+V VR LLD G + T++ + L A G+ ++++LL A ++ + G ++P
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
Query: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
+ A+ G +LD V+LLL +DA+++ + T L A G + KVLL++GA
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424
NG TPL A HV V +LL GA I+ + ES LT +A + GHL +V+ LL
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
Query: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
+ GA ++ T L A GH EVA+ LL + A+VN A ++PL AA GH
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
Query: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543
+ LL+E AN G+TPL AAREGH E V LL + A+ T++ T L +A
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
Query: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603
G VA+ L++ A TPL A +L++VK LL G + H+ G
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
Query: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
T L A + +VA LLQ G ES G TPL AA+ GH V L+SK AN N
Sbjct: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNR 629
Query: 664 GN-KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
+ T + L GH+ V ++L+ HG + G T L A+ G+ +V +LL
Sbjct: 630 ATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
Query: 723 HQADV 727
+ +V
Sbjct: 690 YPNNV 694
Score = 222 bits (565), Expect = 3e-57
Identities = 173/517 (33%), Positives = 255/517 (49%), Gaps = 41/517 (7%)
Query: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
A +G V V +LL + + T++G + L +A AG E+ + L+ ANV + KG
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170
TPL A+ +L++VK LL + A+ N + G T L A G ++V L+N G
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 329
Query: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230
N + ++ G TPL AA ++ VA++LL+ GA
Sbjct: 330 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
Query: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
+N T N + L +A +G++ MVR LL+ GA E KT + T L A +GHV ++
Sbjct: 363 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 421
Query: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348
+LLD GA + + SP+ +AA G H++ LL++ A ++++ + TPL AA
Sbjct: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
Query: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407
GH + +LL +GA N++ T L +AC V + L+K GA I+ TP
Sbjct: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 538
Query: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
L AS GHL +VK LL GA+ + + +T L A GHT+VA LLQ A + ++
Sbjct: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
Query: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKE 526
+ +TPL AAR GH V+ L+ AN N AT HT + +A GH+ V LL
Sbjct: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
Query: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
A K G T L AAK G V LL+ +PN
Sbjct: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD---YPN 692
Score = 208 bits (530), Expect = 3e-53
Identities = 168/515 (32%), Positives = 255/515 (49%), Gaps = 19/515 (3%)
Query: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG- 371
+ GD ++ VR LL +++ T + + L +A G++ +A+VLL A R G
Sbjct: 214 SDGD-VNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGD 272
Query: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
TPL A ++ +++LLL A +++ + +G T L A G + IVK LL GA+
Sbjct: 273 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 332
Query: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLL 490
N TPL AA AGH EVA+ LL + A +N + + ++ L A GH +MV+ LL
Sbjct: 333 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 392
Query: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550
E A+ T HT L A +GHVE LL+ A +PL +AA G V
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
Query: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY-TPLHIA 609
+A LL+ER A+ G TPL A + ++V LLL +G + ++ T L +A
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
Query: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
EVA L++ G TPL A+QEGH E+V LL+ AN + +G
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
Query: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN- 728
T L + GH VADVL++ G ++ + G TPL A+ G++ V+FL+ A+VN
Sbjct: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNR 629
Query: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKV 788
A ++ + A GH +V LLL +GA P DG+T L A + G+
Sbjct: 630 ATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGH--------- 680
Query: 789 VTDETSFVLVSDKHRMSFPET-VDEILDVSEDEGE 822
T+ S++L + +S P T V ++ S+D+ +
Sbjct: 681 -TNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQ 714
Score = 198 bits (504), Expect = 4e-50
Identities = 146/453 (32%), Positives = 226/453 (49%), Gaps = 35/453 (7%)
Query: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
N+ + L AS G++ +V LL + + + + GNTAL A G ++V+ L+N G
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160
AN+ ++ G TPL AA H+EV + LL++GA N + E + L +A +GH ++V
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220
L+ G + + +H T L A ++
Sbjct: 389 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 419
Query: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
VA+LLL+ GA VN + +PL +A+ G+V + LL++RGA +E + TPL AA
Sbjct: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479
Query: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339
R GH + +LL GA I A+T+ + + +A G + L++ A DI L
Sbjct: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 536
Query: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
TPL A+ GH + K LL GA ++ G T L AC+ H V ++LL+ GA ++
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
Query: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQ 458
+E G TPL A+ GHL V+ L+ +GA+ N + + T + +A GH V + LL
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656
Query: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
+ A + KD T L AA+ GHTN+V LL+
Sbjct: 657 HGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
Score = 177 bits (450), Expect = 7e-44
Identities = 139/420 (33%), Positives = 210/420 (50%), Gaps = 14/420 (3%)
Query: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
T + A+ G LD L + D+N+ + G L A G V +V LL++ +E
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
Query: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132
+ G+T L AA AG EV R L+++GA +N S + + L +A + HL++V+FLLE
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
Query: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------LHIAARNDDT 186
GA+Q T++ T L A GH V L++ G +V +PA L +AA
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPLTLAACGGHV 451
Query: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHI 245
AA+L++ N + ++ G+TPL AA + + LLL +GA++N T + T L +
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511
Query: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
A G + L+ GA IE TPL A++ GH+ + + LL GA + A T G
Sbjct: 512 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 568
Query: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
+ + A + H D +LLQ A+++ + TPL AA GH + L+ KGA N
Sbjct: 569 DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVN 628
Query: 366 -SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
+ A N T + +AC H+ V+ELLL GA + G T L A+ GH +V LL
Sbjct: 629 RATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
Score = 160 bits (405), Expect = 1e-38
Identities = 126/398 (31%), Positives = 197/398 (49%), Gaps = 35/398 (8%)
Query: 14 TSFLRAARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILE 72
T + AA +G+++ A L +G INT N+ + L LA +GH+ MV LL E
Sbjct: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399
Query: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
T + +TAL A + G EV R L++ GA VN + +PL +AA H+E+ L+E
Sbjct: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459
Query: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192
GAN ++G+TPL A ++GHE +VA L+ G +I A+ ++T+ A+
Sbjct: 460 RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA---------NINAQTEETQETALT 510
Query: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252
L GF+ VA L+ GA + TPL AS+ G++
Sbjct: 511 L--------ACCGGFS-----------EVADFLIKAGADIEL---GCSTPLMEASQEGHL 548
Query: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
+V+ LL GA + T T L A NGH ++++LL GA ++ +++ G +P+ A
Sbjct: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 608
Query: 313 AQGDHLDCVRLLLQYDAEIDDITL--DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370
A+ HL V+ L+ A ++ T DH T + +A GH V ++LL GA P R +
Sbjct: 609 ARAGHLCTVQFLISKGANVNRATANNDH-TVVSLACAGGHLAVVELLLAHGADPTHRLKD 667
Query: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
G T L A K H V+ LL ++ +V + ++ L
Sbjct: 668 GSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQL 705
Score = 157 bits (398), Expect = 7e-38
Identities = 135/485 (27%), Positives = 229/485 (47%), Gaps = 33/485 (6%)
Query: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
+T L +A GH E+ L+ AK+ + K TPL AA GH +V++LL+ +
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
Query: 498 LATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
+ TPL +A G E V LL + A++ +TPL +AA G V + ++LL
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
Query: 557 ERDAHPNA--AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA-WNGYTPLHIAAKQN 613
A N+ K G++PL +A + ++ VKLLL G ++ N T L +A Q
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
Query: 614 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN--KSGLTP 671
+ EV LL + + G+TPL AA G+AE+ +LL K A+ N S T
Sbjct: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295
Query: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731
L + A +GH ++LI G +D + G TPL +AS+ G+ +V+ L+Q ADV+A
Sbjct: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355
Query: 732 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK---- 787
+PL A ++GH +V L+K N+ SD + + + I+ ++LK
Sbjct: 1356 NRKITPLMSAFRKGHVKVVQYLVK---EVNQFPSD----IECMRYIATITDKELLKKCHQ 1408
Query: 788 ----VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKEL 843
+V + ++K+ + +D E + L + + +R++ R +E++
Sbjct: 1409 CVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKKEEQ- 1467
Query: 844 LDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLI-PSSPATETSDNI 902
K Q + P+ +PE E++E+ ++ +++ I P S T T+ I
Sbjct: 1468 -----KRKQEEDEENKPKENSELPE-----DEDEEENDEDVEQEVPIEPPSATTTTTIGI 1517
Query: 903 SPVAS 907
S ++
Sbjct: 1518 SATSA 1522
Score = 157 bits (396), Expect = 1e-37
Identities = 119/333 (35%), Positives = 166/333 (49%), Gaps = 7/333 (2%)
Query: 397 IDAVTESGL-TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
IDA TES T L +A GH +V L+ R A + K TPL +AA AGH V +
Sbjct: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
Query: 456 LLQNKAKVNAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 514
LL + A++ + TPL A G +V LLL AN + +TPL +AA G
Sbjct: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166
Query: 515 HVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLT 571
+V + LL E + +K G +PL +AA G V +LLL+ + NA + N T
Sbjct: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226
Query: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
L +A ++V LLL R + A G TPL AA EV R LL G NA
Sbjct: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
Query: 632 SVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
V T L +AA +GH + LL+ + A+ ++ NK G TPL L + GH V +L++
Sbjct: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
Query: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
G VDA TPL A G++K+V++L++
Sbjct: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 157 bits (396), Expect = 1e-37
Identities = 113/327 (34%), Positives = 168/327 (51%), Gaps = 6/327 (1%)
Query: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
+H T L +A GH + VL+ + AK R GFTPL +A HV V+E+LL G
Sbjct: 1054 NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD 1113
Query: 397 IDAVTE-SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
I+A +E + TPL +A G +V LL RGA+ NV TPL +AA G+ + K
Sbjct: 1114 IEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1173
Query: 456 LLQNKAKVNAK--AKDDQTPLHCAARIGHTNMVKLLLENNANPNL-ATTAGHTPLHIAAR 512
LL A++N++ +K +PL AA GH VKLLL+ ++ N T +T L +A
Sbjct: 1174 LLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACF 1233
Query: 513 EGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA--AGKNGL 570
+G E V LL+++A+ K G TPL AA G V +LL++ A NA +
Sbjct: 1234 QGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1293
Query: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
T L +A + +LL+ RG G TPL +A+ +V + L+Q G +A
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353
Query: 631 ESVQGVTPLHLAAQEGHAEMVALLLSK 657
+ +TPL A ++GH ++V L+ +
Sbjct: 1354 ADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Score = 155 bits (393), Expect = 3e-37
Identities = 121/381 (31%), Positives = 187/381 (49%), Gaps = 24/381 (6%)
Query: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
+D +T N L LA GH ++V L+ ++ +E KKG T L +AA AG VV
Sbjct: 1047 IDAHT-ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105
Query: 96 ELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 154
L++ G ++ AQS++ TPL +A EVV LL GAN+ +TPL++A
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165
Query: 155 GHENVVAHLINYG------TKGKVRLPALHIAARNDDTRTAAVLLQ--NDPNPDVLSKTG 206
G+ N++ L+N G T K+ + L +AA N +LL +D N + +
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225
Query: 207 FTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 266
T L +A V LLL+R A+V + G+TPL A+ G + R+LLD+GA +
Sbjct: 1226 -TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284
Query: 267 TK--TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
T L AA GH + E+L+ GA I + K G +P+ +A+ G H D V+LL
Sbjct: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
Query: 325 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHV 384
+Q A++D +TPL A GH +V + L+ + +N F P I C +
Sbjct: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV--------KEVNQF-PSDIECMRYIA 1395
Query: 385 RV--MELLLKTGASIDAVTES 403
+ ELL K ++ + ++
Sbjct: 1396 TITDKELLKKCHQCVETIVKA 1416
Score = 155 bits (392), Expect = 4e-37
Identities = 114/322 (35%), Positives = 163/322 (50%), Gaps = 39/322 (12%)
Query: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF- 234
AL +A +VL+ D + K GFTPL +AA ++ V ++LL++G +
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117
Query: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294
+ + TPL +A G +V LLL RGA E + + TPL AA G+V I +ILL+
Sbjct: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177
Query: 295 GAPIQAKT--KNGLSPIHMAAQGDHLDCVRLLL-----------------------QYDA 329
GA I ++T K G+SP+ +AA H+ V+LLL Q A
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237
Query: 330 EIDDITLDH-----------LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF--TPLH 376
E+ + LD LTPL AA G+ V +VLLDKGA N+ + T L
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297
Query: 377 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK 436
IA K H + ELL+ GA ID + G TPL +AS GH +V+ L+Q GA + ++ +
Sbjct: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1357
Query: 437 VETPLHMAARAGHTEVAKYLLQ 458
TPL A R GH +V +YL++
Sbjct: 1358 KITPLMSAFRKGHVKVVQYLVK 1379
Score = 141 bits (355), Expect = 7e-33
Identities = 125/403 (31%), Positives = 174/403 (43%), Gaps = 67/403 (16%)
Query: 451 EVAKYLLQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509
E A L + KA+ + A D L A G N V+ LL+ + N T G + L +
Sbjct: 185 EAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCL 244
Query: 510 AAREGHVETVLALLEKEASQACMTKKG-FTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 568
A G+ E LL A+ KG TPL A+ G + + +LLL DA N+
Sbjct: 245 ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSAT 304
Query: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628
G T L A +DIVK+LL G + NG+TPL AA VEVAR LL +G
Sbjct: 305 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 364
Query: 629 NAESVQGV----------------------------------TPLHLAAQEGHAEMVALL 654
N S + T L A +GH E+ LL
Sbjct: 365 NTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 424
Query: 655 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNI 714
L A N+ S +PL L A GHV +A +LI+ G ++ GYTPL A+ G+
Sbjct: 425 LDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHE 484
Query: 715 KLVKFLLQHQADVNAKT------------------------------KLGYS-PLHQAAQ 743
++V LL A++NA+T +LG S PL +A+Q
Sbjct: 485 EMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQ 544
Query: 744 QGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
+GH ++V LL +GA+ + ++ G T L A G+ V DVL
Sbjct: 545 EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
Score = 79.7 bits (195), Expect = 2e-14
Identities = 53/159 (33%), Positives = 82/159 (51%), Gaps = 1/159 (0%)
Query: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
E +T + A++ G+L+ L +G +++ G L A + GH + LL
Sbjct: 532 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
Query: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVV 127
LE ++ G T L AA AG V+ L++ GANVN A + T + +A HL VV
Sbjct: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVV 651
Query: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
+ LL +GA+ +DG T L A + GH NVV++L++Y
Sbjct: 652 ELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 66.6 bits (161), Expect = 2e-10
Identities = 41/131 (31%), Positives = 68/131 (51%), Gaps = 2/131 (1%)
Query: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMV 61
+V R T + AA G + L G D+N + L +A+ +GH K
Sbjct: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1308
Query: 62 VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
L+H+ ++ KKGNT L +A+ G +VV+ LV GA+V+A + TPL A ++
Sbjct: 1309 ELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRK 1368
Query: 122 NHLEVVKFLLE 132
H++VV++L++
Sbjct: 1369 GHVKVVQYLVK 1379
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 223 bits (569), Expect = 1e-57
Identities = 168/485 (34%), Positives = 243/485 (50%), Gaps = 13/485 (2%)
Query: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308
G+V VR LLD G + T++ + L A G+ ++++LL A ++ + G ++P
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
Query: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
+ A+ G +LD V+LLL +DA+++ + T L A G + KVLL++GA
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424
NG TPL A HV V +LL GA I+ + ES LT +A + GHL +V+ LL
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
Query: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
+ GA ++ T L A GH EVA+ LL + A+VN A ++PL AA GH
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
Query: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543
+ LL+E AN G+TPL AAREGH E V LL + A+ T++ T L +A
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
Query: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603
G VA+ L++ A TPL A +L++VK LL G + H+ G
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
Query: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
T L A + +VA LLQ G ES G TPL AA+ GH V L+SK AN N
Sbjct: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNR 629
Query: 664 GN-KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
+ T + L GH+ V ++L+ HG + G T L A+ G+ +V +LL
Sbjct: 630 ATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
Query: 723 HQADV 727
+ +V
Sbjct: 690 YPNNV 694
Score = 222 bits (565), Expect = 3e-57
Identities = 173/517 (33%), Positives = 255/517 (49%), Gaps = 41/517 (7%)
Query: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
A +G V V +LL + + T++G + L +A AG E+ + L+ ANV + KG
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170
TPL A+ +L++VK LL + A+ N + G T L A G ++V L+N G
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 329
Query: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230
N + ++ G TPL AA ++ VA++LL+ GA
Sbjct: 330 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
Query: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
+N T N + L +A +G++ MVR LL+ GA E KT + T L A +GHV ++
Sbjct: 363 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 421
Query: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348
+LLD GA + + SP+ +AA G H++ LL++ A ++++ + TPL AA
Sbjct: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
Query: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407
GH + +LL +GA N++ T L +AC V + L+K GA I+ TP
Sbjct: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 538
Query: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
L AS GHL +VK LL GA+ + + +T L A GHT+VA LLQ A + ++
Sbjct: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
Query: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKE 526
+ +TPL AAR GH V+ L+ AN N AT HT + +A GH+ V LL
Sbjct: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
Query: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
A K G T L AAK G V LL+ +PN
Sbjct: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD---YPN 692
Score = 208 bits (530), Expect = 3e-53
Identities = 168/515 (32%), Positives = 255/515 (49%), Gaps = 19/515 (3%)
Query: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG- 371
+ GD ++ VR LL +++ T + + L +A G++ +A+VLL A R G
Sbjct: 214 SDGD-VNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGD 272
Query: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
TPL A ++ +++LLL A +++ + +G T L A G + IVK LL GA+
Sbjct: 273 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 332
Query: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLL 490
N TPL AA AGH EVA+ LL + A +N + + ++ L A GH +MV+ LL
Sbjct: 333 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 392
Query: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550
E A+ T HT L A +GHVE LL+ A +PL +AA G V
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
Query: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY-TPLHIA 609
+A LL+ER A+ G TPL A + ++V LLL +G + ++ T L +A
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
Query: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
EVA L++ G TPL A+QEGH E+V LL+ AN + +G
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
Query: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN- 728
T L + GH VADVL++ G ++ + G TPL A+ G++ V+FL+ A+VN
Sbjct: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNR 629
Query: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKV 788
A ++ + A GH +V LLL +GA P DG+T L A + G+
Sbjct: 630 ATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGH--------- 680
Query: 789 VTDETSFVLVSDKHRMSFPET-VDEILDVSEDEGE 822
T+ S++L + +S P T V ++ S+D+ +
Sbjct: 681 -TNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQ 714
Score = 198 bits (504), Expect = 4e-50
Identities = 146/453 (32%), Positives = 226/453 (49%), Gaps = 35/453 (7%)
Query: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
N+ + L AS G++ +V LL + + + + GNTAL A G ++V+ L+N G
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160
AN+ ++ G TPL AA H+EV + LL++GA N + E + L +A +GH ++V
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220
L+ G + + +H T L A ++
Sbjct: 389 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 419
Query: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
VA+LLL+ GA VN + +PL +A+ G+V + LL++RGA +E + TPL AA
Sbjct: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479
Query: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339
R GH + +LL GA I A+T+ + + +A G + L++ A DI L
Sbjct: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 536
Query: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
TPL A+ GH + K LL GA ++ G T L AC+ H V ++LL+ GA ++
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
Query: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQ 458
+E G TPL A+ GHL V+ L+ +GA+ N + + T + +A GH V + LL
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656
Query: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
+ A + KD T L AA+ GHTN+V LL+
Sbjct: 657 HGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
Score = 177 bits (450), Expect = 7e-44
Identities = 139/420 (33%), Positives = 210/420 (50%), Gaps = 14/420 (3%)
Query: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
T + A+ G LD L + D+N+ + G L A G V +V LL++ +E
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
Query: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132
+ G+T L AA AG EV R L+++GA +N S + + L +A + HL++V+FLLE
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
Query: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------LHIAARNDDT 186
GA+Q T++ T L A GH V L++ G +V +PA L +AA
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPLTLAACGGHV 451
Query: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHI 245
AA+L++ N + ++ G+TPL AA + + LLL +GA++N T + T L +
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511
Query: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
A G + L+ GA IE TPL A++ GH+ + + LL GA + A T G
Sbjct: 512 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 568
Query: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
+ + A + H D +LLQ A+++ + TPL AA GH + L+ KGA N
Sbjct: 569 DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVN 628
Query: 366 -SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
+ A N T + +AC H+ V+ELLL GA + G T L A+ GH +V LL
Sbjct: 629 RATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
Score = 160 bits (405), Expect = 1e-38
Identities = 126/398 (31%), Positives = 197/398 (49%), Gaps = 35/398 (8%)
Query: 14 TSFLRAARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILE 72
T + AA +G+++ A L +G INT N+ + L LA +GH+ MV LL E
Sbjct: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399
Query: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
T + +TAL A + G EV R L++ GA VN + +PL +AA H+E+ L+E
Sbjct: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459
Query: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192
GAN ++G+TPL A ++GHE +VA L+ G +I A+ ++T+ A+
Sbjct: 460 RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA---------NINAQTEETQETALT 510
Query: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252
L GF+ VA L+ GA + TPL AS+ G++
Sbjct: 511 L--------ACCGGFS-----------EVADFLIKAGADIEL---GCSTPLMEASQEGHL 548
Query: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
+V+ LL GA + T T L A NGH ++++LL GA ++ +++ G +P+ A
Sbjct: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 608
Query: 313 AQGDHLDCVRLLLQYDAEIDDITL--DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370
A+ HL V+ L+ A ++ T DH T + +A GH V ++LL GA P R +
Sbjct: 609 ARAGHLCTVQFLISKGANVNRATANNDH-TVVSLACAGGHLAVVELLLAHGADPTHRLKD 667
Query: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
G T L A K H V+ LL ++ +V + ++ L
Sbjct: 668 GSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQL 705
Score = 157 bits (398), Expect = 7e-38
Identities = 135/485 (27%), Positives = 229/485 (47%), Gaps = 33/485 (6%)
Query: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
+T L +A GH E+ L+ AK+ + K TPL AA GH +V++LL+ +
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
Query: 498 LATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
+ TPL +A G E V LL + A++ +TPL +AA G V + ++LL
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
Query: 557 ERDAHPNA--AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA-WNGYTPLHIAAKQN 613
A N+ K G++PL +A + ++ VKLLL G ++ N T L +A Q
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
Query: 614 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN--KSGLTP 671
+ EV LL + + G+TPL AA G+AE+ +LL K A+ N S T
Sbjct: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295
Query: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731
L + A +GH ++LI G +D + G TPL +AS+ G+ +V+ L+Q ADV+A
Sbjct: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355
Query: 732 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK---- 787
+PL A ++GH +V L+K N+ SD + + + I+ ++LK
Sbjct: 1356 NRKITPLMSAFRKGHVKVVQYLVK---EVNQFPSD----IECMRYIATITDKELLKKCHQ 1408
Query: 788 ----VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKEL 843
+V + ++K+ + +D E + L + + +R++ R +E++
Sbjct: 1409 CVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKKEEQ- 1467
Query: 844 LDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLI-PSSPATETSDNI 902
K Q + P+ +PE E++E+ ++ +++ I P S T T+ I
Sbjct: 1468 -----KRKQEEDEENKPKENSELPE-----DEDEEENDEDVEQEVPIEPPSATTTTTIGI 1517
Query: 903 SPVAS 907
S ++
Sbjct: 1518 SATSA 1522
Score = 157 bits (396), Expect = 1e-37
Identities = 119/333 (35%), Positives = 166/333 (49%), Gaps = 7/333 (2%)
Query: 397 IDAVTESGL-TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
IDA TES T L +A GH +V L+ R A + K TPL +AA AGH V +
Sbjct: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
Query: 456 LLQNKAKVNAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 514
LL + A++ + TPL A G +V LLL AN + +TPL +AA G
Sbjct: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166
Query: 515 HVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLT 571
+V + LL E + +K G +PL +AA G V +LLL+ + NA + N T
Sbjct: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226
Query: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
L +A ++V LLL R + A G TPL AA EV R LL G NA
Sbjct: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
Query: 632 SVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
V T L +AA +GH + LL+ + A+ ++ NK G TPL L + GH V +L++
Sbjct: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
Query: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
G VDA TPL A G++K+V++L++
Sbjct: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 157 bits (396), Expect = 1e-37
Identities = 113/327 (34%), Positives = 168/327 (51%), Gaps = 6/327 (1%)
Query: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
+H T L +A GH + VL+ + AK R GFTPL +A HV V+E+LL G
Sbjct: 1054 NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD 1113
Query: 397 IDAVTE-SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
I+A +E + TPL +A G +V LL RGA+ NV TPL +AA G+ + K
Sbjct: 1114 IEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1173
Query: 456 LLQNKAKVNAK--AKDDQTPLHCAARIGHTNMVKLLLENNANPNL-ATTAGHTPLHIAAR 512
LL A++N++ +K +PL AA GH VKLLL+ ++ N T +T L +A
Sbjct: 1174 LLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACF 1233
Query: 513 EGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA--AGKNGL 570
+G E V LL+++A+ K G TPL AA G V +LL++ A NA +
Sbjct: 1234 QGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1293
Query: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
T L +A + +LL+ RG G TPL +A+ +V + L+Q G +A
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353
Query: 631 ESVQGVTPLHLAAQEGHAEMVALLLSK 657
+ +TPL A ++GH ++V L+ +
Sbjct: 1354 ADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Score = 155 bits (393), Expect = 3e-37
Identities = 121/381 (31%), Positives = 187/381 (49%), Gaps = 24/381 (6%)
Query: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
+D +T N L LA GH ++V L+ ++ +E KKG T L +AA AG VV
Sbjct: 1047 IDAHT-ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105
Query: 96 ELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 154
L++ G ++ AQS++ TPL +A EVV LL GAN+ +TPL++A
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165
Query: 155 GHENVVAHLINYG------TKGKVRLPALHIAARNDDTRTAAVLLQ--NDPNPDVLSKTG 206
G+ N++ L+N G T K+ + L +AA N +LL +D N + +
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225
Query: 207 FTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 266
T L +A V LLL+R A+V + G+TPL A+ G + R+LLD+GA +
Sbjct: 1226 -TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284
Query: 267 TK--TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
T L AA GH + E+L+ GA I + K G +P+ +A+ G H D V+LL
Sbjct: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
Query: 325 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHV 384
+Q A++D +TPL A GH +V + L+ + +N F P I C +
Sbjct: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV--------KEVNQF-PSDIECMRYIA 1395
Query: 385 RV--MELLLKTGASIDAVTES 403
+ ELL K ++ + ++
Sbjct: 1396 TITDKELLKKCHQCVETIVKA 1416
Score = 155 bits (392), Expect = 4e-37
Identities = 114/322 (35%), Positives = 163/322 (50%), Gaps = 39/322 (12%)
Query: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF- 234
AL +A +VL+ D + K GFTPL +AA ++ V ++LL++G +
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117
Query: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294
+ + TPL +A G +V LLL RGA E + + TPL AA G+V I +ILL+
Sbjct: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177
Query: 295 GAPIQAKT--KNGLSPIHMAAQGDHLDCVRLLL-----------------------QYDA 329
GA I ++T K G+SP+ +AA H+ V+LLL Q A
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237
Query: 330 EIDDITLDH-----------LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF--TPLH 376
E+ + LD LTPL AA G+ V +VLLDKGA N+ + T L
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297
Query: 377 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK 436
IA K H + ELL+ GA ID + G TPL +AS GH +V+ L+Q GA + ++ +
Sbjct: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1357
Query: 437 VETPLHMAARAGHTEVAKYLLQ 458
TPL A R GH +V +YL++
Sbjct: 1358 KITPLMSAFRKGHVKVVQYLVK 1379
Score = 141 bits (355), Expect = 7e-33
Identities = 125/403 (31%), Positives = 174/403 (43%), Gaps = 67/403 (16%)
Query: 451 EVAKYLLQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509
E A L + KA+ + A D L A G N V+ LL+ + N T G + L +
Sbjct: 185 EAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCL 244
Query: 510 AAREGHVETVLALLEKEASQACMTKKG-FTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 568
A G+ E LL A+ KG TPL A+ G + + +LLL DA N+
Sbjct: 245 ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSAT 304
Query: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628
G T L A +DIVK+LL G + NG+TPL AA VEVAR LL +G
Sbjct: 305 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 364
Query: 629 NAESVQGV----------------------------------TPLHLAAQEGHAEMVALL 654
N S + T L A +GH E+ LL
Sbjct: 365 NTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 424
Query: 655 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNI 714
L A N+ S +PL L A GHV +A +LI+ G ++ GYTPL A+ G+
Sbjct: 425 LDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHE 484
Query: 715 KLVKFLLQHQADVNAKT------------------------------KLGYS-PLHQAAQ 743
++V LL A++NA+T +LG S PL +A+Q
Sbjct: 485 EMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQ 544
Query: 744 QGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
+GH ++V LL +GA+ + ++ G T L A G+ V DVL
Sbjct: 545 EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
Score = 79.7 bits (195), Expect = 2e-14
Identities = 53/159 (33%), Positives = 82/159 (51%), Gaps = 1/159 (0%)
Query: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
E +T + A++ G+L+ L +G +++ G L A + GH + LL
Sbjct: 532 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
Query: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVV 127
LE ++ G T L AA AG V+ L++ GANVN A + T + +A HL VV
Sbjct: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVV 651
Query: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
+ LL +GA+ +DG T L A + GH NVV++L++Y
Sbjct: 652 ELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 66.6 bits (161), Expect = 2e-10
Identities = 41/131 (31%), Positives = 68/131 (51%), Gaps = 2/131 (1%)
Query: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMV 61
+V R T + AA G + L G D+N + L +A+ +GH K
Sbjct: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1308
Query: 62 VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
L+H+ ++ KKGNT L +A+ G +VV+ LV GA+V+A + TPL A ++
Sbjct: 1309 ELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRK 1368
Query: 122 NHLEVVKFLLE 132
H++VV++L++
Sbjct: 1369 GHVKVVQYLVK 1379
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 199 bits (507), Expect = 2e-50
Identities = 150/506 (29%), Positives = 245/506 (48%), Gaps = 18/506 (3%)
Query: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
G T L LA + + L+ GA+VN T L++AAQ+ + +K LL AN
Sbjct: 48 GRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANW 107
Query: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV------RLPALHIAARNDDTRTAAV 191
+ TPL + + +A L+ + G+V + ALH +A ++ +
Sbjct: 108 MQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKL 167
Query: 192 LLQNDPNPDVLSKTGFTPLHIAAHYEN---LNVAQLLLNRGAS---VNFTPQNGITPLHI 245
L+++D N + G PLH AA++++ ++ + +L+ + +N+ G TPLH
Sbjct: 168 LIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHF 227
Query: 246 ASRRGNVIMVRLLLD-RGAQIETKTKDELTPLHCAARNGHVRISEILLDHG-APIQAKTK 303
A GNV +V +L I + TPLH AA GH +I +LL+ +
Sbjct: 228 AVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS 287
Query: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD--KG 361
G +P+H AAQ + + V++ L++ + DD L+ T AA G V + +L
Sbjct: 288 QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSD 347
Query: 362 AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVK 421
N G T LH A HV ++LLL+ A +DA TPL A MGH +++
Sbjct: 348 IDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQ 407
Query: 422 NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481
L++ GA ++ + + LH AA G+ +V + L++NK N + +TPL CAA G
Sbjct: 408 TLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGG 467
Query: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA--SQACMTKKGFTP 539
+ N + +L+ENNA+PN+ G T LH + G+++ + LL+ A +Q ++ +TP
Sbjct: 468 YINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTP 527
Query: 540 LHVAAKYGKVRVAELLLERDAHPNAA 565
L A + V + +LE A AA
Sbjct: 528 LDYALLGERHEVIQFMLEHGALSIAA 553
Score = 191 bits (485), Expect = 6e-48
Identities = 156/531 (29%), Positives = 245/531 (46%), Gaps = 21/531 (3%)
Query: 82 LHIAALAGQDEVVREL-VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVA 140
+H AA+ G ++ L V A + + Q G TPL + L+ LL+ GA+ N
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 141 TEDGFTPLAVALQQGHENVVAHLI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQ-- 194
T L +A Q+G+ + L+ N+ K + LH+ R+ + A+LL+
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
Query: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN--- 251
D K T LH +A+Y N +LL+ +++ G PLH A+ +
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
Query: 252 VIMVRLLLDRG---AQIETKTKDELTPLHCAARNGHVRISEILLDH-GAPIQAKTKNGLS 307
V VR +LD + + + + TPLH A +G+V + ++L + I + +
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257
Query: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDH--LTPLHVAAHCGHHRVAKVLLDKGAKPN 365
P+H AA H V LLL+ + I D TPLH AA KV L + +
Sbjct: 258 PLHWAALLGHAQIVHLLLERNKS-GTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKD 316
Query: 366 SRALNGFTPLHIACKKNHVRVME--LLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
L G T A K V+ L LK+ I+ + G T LH A+ GH+ VK L
Sbjct: 317 DSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLL 376
Query: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
L+ A + ++V TPL A GH +V + L++ A+V+ +D + LH AA G+
Sbjct: 377 LENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNA 436
Query: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
++ ++L+EN NPN+ AG TPL AA G++ + L+E A K+G T LH +
Sbjct: 437 DVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWS 496
Query: 544 AKYGKVRVAELLLERDAHPNAAGKN--GLTPLHVAVHHNNLDIVKLLLPRG 592
G + +LLL+ A PN N TPL A+ ++++ +L G
Sbjct: 497 CNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHG 547
Score = 184 bits (466), Expect = 9e-46
Identities = 165/637 (25%), Positives = 287/637 (45%), Gaps = 40/637 (6%)
Query: 276 LHCAARNGHV-RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI 334
+H AA NG + +++ + A + + G +P+ D LDC LL+ A+++
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 335 TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 394
T LH+AA G++R K+LL + A + L TPLH+ + + + LLLK
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
Query: 395 A--SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR-----A 447
A +D ++ T LH +++ + VK L++ ++ + +V+ + PLH AA A
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
Query: 448 GHTEVAKYLLQ---NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE-NNANPNLATTAG 503
HT + +L ++ +N + + +TPLH A G+ +V +L + N
Sbjct: 198 VHT--VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLF 255
Query: 504 HTPLHIAAREGHVETVLALLEKEASQACMT-KKGFTPLHVAAKYGKVRVAELLLERDAHP 562
TPLH AA GH + V LLE+ S + +G TPLH AA+ ++ L+ +
Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVK 315
Query: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY--TPLHIAAKQNQVEVARS 620
+ + G T A + D+++ +L + Y T LH AA V +
Sbjct: 316 DDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKL 375
Query: 621 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680
LL+ +A V TPL A + GH +++ L+ A +L ++ G + LH A G+
Sbjct: 376 LLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGN 435
Query: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 740
V +LI++ + + G TPL A++ G I + L+++ AD N + K G + LH
Sbjct: 436 ADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHW 495
Query: 741 AAQQGHTDIVTLLLKNGASPNEV--SSDGTTPLAIA------------KRLGYISVTDVL 786
+ G+ D + LLL A PN++ + + TPL A G +S+ +
Sbjct: 496 SCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQ 555
Query: 787 KVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDF 846
+ + V K R +F + +L E ++ + K E + R E++
Sbjct: 556 DIAAFKIQAVYKGYKVRKAFRDR-KNLLMKHEQLRKDAAAKKREEENKRKEAEQQ----- 609
Query: 847 VPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKE 883
K + +S +PC +P T + S + SK+
Sbjct: 610 --KGRRSPDSCRPQALPC-LPSTQDVPSRQSRAPSKQ 643
Score = 166 bits (421), Expect = 2e-40
Identities = 145/529 (27%), Positives = 235/529 (44%), Gaps = 45/529 (8%)
Query: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
T + + LD A L+ G D+N + + LHLA+++G+ + + LL +
Sbjct: 50 TPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQ 109
Query: 74 TTKKGNTALHIAALAGQDEVVRELVNYGA--NVNAQSQKGFTPLYMAAQENHLEVVKFLL 131
+ T LH+ + + L+ + A V+ Q + T L+ +A N+ E VK L+
Sbjct: 110 KDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLI 169
Query: 132 ENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDD---TRT 188
++ +N + +G P LH AA + D T
Sbjct: 170 KHDSNIGIPDVEGKIP-----------------------------LHWAANHKDPSAVHT 200
Query: 189 AAVLLQNDPNPDVLS---KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI--TPL 243
+L P +L+ G TPLH A N+ V +L + S N T + + TPL
Sbjct: 201 VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY-ESCNITSYDNLFRTPL 259
Query: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDE-LTPLHCAARNGHVRISEILLDHGAPIQAKT 302
H A+ G+ +V LLL+R + + TPLH AA++ ++ L H +
Sbjct: 260 HWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSD 319
Query: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDK 360
G + AA D +R +L ++ID D T LH AA GH K+LL+
Sbjct: 320 LEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLEN 379
Query: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
A+ ++ + TPL AC+ H V++ L+K GA +D V + G + LH A+ G+ +
Sbjct: 380 NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVC 439
Query: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
+ L++ +PNV + TPL AA G+ L++N A N + K+ +T LH +
Sbjct: 440 QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNN 499
Query: 481 GHTNMVKLLLENNANPNLA--TTAGHTPLHIAAREGHVETVLALLEKEA 527
G+ + +KLLL+ A PN +TPL A E + +LE A
Sbjct: 500 GYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
Score = 92.4 bits (228), Expect = 4e-18
Identities = 74/259 (28%), Positives = 118/259 (45%), Gaps = 33/259 (12%)
Query: 9 EADAATSFLRAARSGNLD--KALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH 66
+ + TSF+ AA G+ D + + L++ +DIN ++ G LH A+ GHV V LL
Sbjct: 319 DLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLE 378
Query: 67 KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126
++ T +T L A G +V++ L+ GA V+ Q G + L+ AA + +V
Sbjct: 379 NNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADV 438
Query: 127 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186
+ L+EN N NV G TPL A G+ N +
Sbjct: 439 CQILIENKINPNVQDYAGRTPLQCAAYGGYINCM-------------------------- 472
Query: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLH 244
AVL++N+ +P++ K G T LH + + L+ +LLL+ A N N TPL
Sbjct: 473 ---AVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLD 529
Query: 245 IASRRGNVIMVRLLLDRGA 263
A +++ +L+ GA
Sbjct: 530 YALLGERHEVIQFMLEHGA 548
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 199 bits (507), Expect = 2e-50
Identities = 150/506 (29%), Positives = 245/506 (48%), Gaps = 18/506 (3%)
Query: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
G T L LA + + L+ GA+VN T L++AAQ+ + +K LL AN
Sbjct: 48 GRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANW 107
Query: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV------RLPALHIAARNDDTRTAAV 191
+ TPL + + +A L+ + G+V + ALH +A ++ +
Sbjct: 108 MQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKL 167
Query: 192 LLQNDPNPDVLSKTGFTPLHIAAHYEN---LNVAQLLLNRGAS---VNFTPQNGITPLHI 245
L+++D N + G PLH AA++++ ++ + +L+ + +N+ G TPLH
Sbjct: 168 LIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHF 227
Query: 246 ASRRGNVIMVRLLLD-RGAQIETKTKDELTPLHCAARNGHVRISEILLDHG-APIQAKTK 303
A GNV +V +L I + TPLH AA GH +I +LL+ +
Sbjct: 228 AVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS 287
Query: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD--KG 361
G +P+H AAQ + + V++ L++ + DD L+ T AA G V + +L
Sbjct: 288 QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSD 347
Query: 362 AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVK 421
N G T LH A HV ++LLL+ A +DA TPL A MGH +++
Sbjct: 348 IDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQ 407
Query: 422 NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481
L++ GA ++ + + LH AA G+ +V + L++NK N + +TPL CAA G
Sbjct: 408 TLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGG 467
Query: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA--SQACMTKKGFTP 539
+ N + +L+ENNA+PN+ G T LH + G+++ + LL+ A +Q ++ +TP
Sbjct: 468 YINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTP 527
Query: 540 LHVAAKYGKVRVAELLLERDAHPNAA 565
L A + V + +LE A AA
Sbjct: 528 LDYALLGERHEVIQFMLEHGALSIAA 553
Score = 191 bits (485), Expect = 6e-48
Identities = 156/531 (29%), Positives = 245/531 (46%), Gaps = 21/531 (3%)
Query: 82 LHIAALAGQDEVVREL-VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVA 140
+H AA+ G ++ L V A + + Q G TPL + L+ LL+ GA+ N
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 141 TEDGFTPLAVALQQGHENVVAHLI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQ-- 194
T L +A Q+G+ + L+ N+ K + LH+ R+ + A+LL+
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
Query: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN--- 251
D K T LH +A+Y N +LL+ +++ G PLH A+ +
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
Query: 252 VIMVRLLLDRG---AQIETKTKDELTPLHCAARNGHVRISEILLDH-GAPIQAKTKNGLS 307
V VR +LD + + + + TPLH A +G+V + ++L + I + +
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257
Query: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDH--LTPLHVAAHCGHHRVAKVLLDKGAKPN 365
P+H AA H V LLL+ + I D TPLH AA KV L + +
Sbjct: 258 PLHWAALLGHAQIVHLLLERNKS-GTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKD 316
Query: 366 SRALNGFTPLHIACKKNHVRVME--LLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
L G T A K V+ L LK+ I+ + G T LH A+ GH+ VK L
Sbjct: 317 DSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLL 376
Query: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
L+ A + ++V TPL A GH +V + L++ A+V+ +D + LH AA G+
Sbjct: 377 LENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNA 436
Query: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
++ ++L+EN NPN+ AG TPL AA G++ + L+E A K+G T LH +
Sbjct: 437 DVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWS 496
Query: 544 AKYGKVRVAELLLERDAHPNAAGKN--GLTPLHVAVHHNNLDIVKLLLPRG 592
G + +LLL+ A PN N TPL A+ ++++ +L G
Sbjct: 497 CNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHG 547
Score = 184 bits (466), Expect = 9e-46
Identities = 165/637 (25%), Positives = 287/637 (45%), Gaps = 40/637 (6%)
Query: 276 LHCAARNGHV-RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI 334
+H AA NG + +++ + A + + G +P+ D LDC LL+ A+++
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 335 TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 394
T LH+AA G++R K+LL + A + L TPLH+ + + + LLLK
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
Query: 395 A--SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR-----A 447
A +D ++ T LH +++ + VK L++ ++ + +V+ + PLH AA A
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
Query: 448 GHTEVAKYLLQ---NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE-NNANPNLATTAG 503
HT + +L ++ +N + + +TPLH A G+ +V +L + N
Sbjct: 198 VHT--VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLF 255
Query: 504 HTPLHIAAREGHVETVLALLEKEASQACMT-KKGFTPLHVAAKYGKVRVAELLLERDAHP 562
TPLH AA GH + V LLE+ S + +G TPLH AA+ ++ L+ +
Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVK 315
Query: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY--TPLHIAAKQNQVEVARS 620
+ + G T A + D+++ +L + Y T LH AA V +
Sbjct: 316 DDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKL 375
Query: 621 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680
LL+ +A V TPL A + GH +++ L+ A +L ++ G + LH A G+
Sbjct: 376 LLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGN 435
Query: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 740
V +LI++ + + G TPL A++ G I + L+++ AD N + K G + LH
Sbjct: 436 ADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHW 495
Query: 741 AAQQGHTDIVTLLLKNGASPNEV--SSDGTTPLAIA------------KRLGYISVTDVL 786
+ G+ D + LLL A PN++ + + TPL A G +S+ +
Sbjct: 496 SCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQ 555
Query: 787 KVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDF 846
+ + V K R +F + +L E ++ + K E + R E++
Sbjct: 556 DIAAFKIQAVYKGYKVRKAFRDR-KNLLMKHEQLRKDAAAKKREEENKRKEAEQQ----- 609
Query: 847 VPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKE 883
K + +S +PC +P T + S + SK+
Sbjct: 610 --KGRRSPDSCRPQALPC-LPSTQDVPSRQSRAPSKQ 643
Score = 166 bits (421), Expect = 2e-40
Identities = 145/529 (27%), Positives = 235/529 (44%), Gaps = 45/529 (8%)
Query: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
T + + LD A L+ G D+N + + LHLA+++G+ + + LL +
Sbjct: 50 TPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQ 109
Query: 74 TTKKGNTALHIAALAGQDEVVRELVNYGA--NVNAQSQKGFTPLYMAAQENHLEVVKFLL 131
+ T LH+ + + L+ + A V+ Q + T L+ +A N+ E VK L+
Sbjct: 110 KDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLI 169
Query: 132 ENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDD---TRT 188
++ +N + +G P LH AA + D T
Sbjct: 170 KHDSNIGIPDVEGKIP-----------------------------LHWAANHKDPSAVHT 200
Query: 189 AAVLLQNDPNPDVLS---KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI--TPL 243
+L P +L+ G TPLH A N+ V +L + S N T + + TPL
Sbjct: 201 VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY-ESCNITSYDNLFRTPL 259
Query: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDE-LTPLHCAARNGHVRISEILLDHGAPIQAKT 302
H A+ G+ +V LLL+R + + TPLH AA++ ++ L H +
Sbjct: 260 HWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSD 319
Query: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDK 360
G + AA D +R +L ++ID D T LH AA GH K+LL+
Sbjct: 320 LEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLEN 379
Query: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
A+ ++ + TPL AC+ H V++ L+K GA +D V + G + LH A+ G+ +
Sbjct: 380 NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVC 439
Query: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
+ L++ +PNV + TPL AA G+ L++N A N + K+ +T LH +
Sbjct: 440 QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNN 499
Query: 481 GHTNMVKLLLENNANPNLA--TTAGHTPLHIAAREGHVETVLALLEKEA 527
G+ + +KLLL+ A PN +TPL A E + +LE A
Sbjct: 500 GYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
Score = 92.4 bits (228), Expect = 4e-18
Identities = 74/259 (28%), Positives = 118/259 (45%), Gaps = 33/259 (12%)
Query: 9 EADAATSFLRAARSGNLD--KALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH 66
+ + TSF+ AA G+ D + + L++ +DIN ++ G LH A+ GHV V LL
Sbjct: 319 DLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLE 378
Query: 67 KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126
++ T +T L A G +V++ L+ GA V+ Q G + L+ AA + +V
Sbjct: 379 NNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADV 438
Query: 127 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186
+ L+EN N NV G TPL A G+ N +
Sbjct: 439 CQILIENKINPNVQDYAGRTPLQCAAYGGYINCM-------------------------- 472
Query: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLH 244
AVL++N+ +P++ K G T LH + + L+ +LLL+ A N N TPL
Sbjct: 473 ---AVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLD 529
Query: 245 IASRRGNVIMVRLLLDRGA 263
A +++ +L+ GA
Sbjct: 530 YALLGERHEVIQFMLEHGA 548
>gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform 1
[Homo sapiens]
Length = 1170
Score = 197 bits (502), Expect = 6e-50
Identities = 221/817 (27%), Positives = 338/817 (41%), Gaps = 85/817 (10%)
Query: 38 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97
+N + NG L LA + L+ + ++ K G + LH G L
Sbjct: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
Query: 98 VNYGANVNAQSQKGF-TPLYMAA-----------QENHLEVVKFLLENGANQNVATEDGF 145
+ GA VNA + TPL++ A ++ + LL+ GAN N+ G
Sbjct: 309 IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368
Query: 146 TPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL-LQNDPNPDVLSK 204
TPL V++ G+E V + L+ + L + ++ + TA L +Q+ S
Sbjct: 369 TPLHVSIMAGNEYVFSQLL--------QCKQLDLELKDHEGSTALWLAVQHITVSSDQSV 420
Query: 205 TGF--TPLHIAAHYENLNVAQLLLNRGASVNFTPQ-NGITPLHIASRRGNVIMVRLLLDR 261
F P+ ++ + A L+ RG+ + G L A+ GN L
Sbjct: 421 NPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATN 480
Query: 262 GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL--------------- 306
GA + + K TPLH A R+G ++ LL GA +T+ L
Sbjct: 481 GAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADS 540
Query: 307 ----SPIHMAAQGDHLDCVRLLLQYDAE----------IDDITLDHL---TPLHVAAHCG 349
+P+HMA +H D V ++L+ A I D +L T L +A G
Sbjct: 541 VHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTG 600
Query: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV-TESGLTPL 408
H +A LL GA N +G T LH+A ++ + LL+ A I+ T+ G T L
Sbjct: 601 MHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETAL 660
Query: 409 HVASFMGHLPIVKNLL-QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
+A LP+V + + RGA +V + K PL +A ++A L+++
Sbjct: 661 QLA-IRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWG 719
Query: 468 KDD----QTPLHCAARIGHTNMVKLLLENNANPNLATTAG------------HTPLHIAA 511
QT LH A + L+ + + N G TPLH+AA
Sbjct: 720 PGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAA 779
Query: 512 REGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER-DAHPNAAGKNGL 570
G ETV LLE A+ +G TP+HVA + +LL+ D H N + GL
Sbjct: 780 SWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGL 839
Query: 571 TPLHVAVHHNNLDIVKLLLPR-GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
TP A+ N + +L R G+ G LH+A + + +E L+ + N
Sbjct: 840 TPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVN 899
Query: 630 A--ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVL 687
+ + +TPLHLA Q G +V LL A N K T LHL AQ+ + VL
Sbjct: 900 SRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVL 959
Query: 688 IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL-QHQADVNAKTKLGYSPLHQAAQQGH 746
+++GV A G LH+A +G + ++ LL + D A G SPLH Q G
Sbjct: 960 LENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGK 1019
Query: 747 TD---IVTLLLK--NGASPNEVSSDGTTPLAIAKRLG 778
+ I L L+ G ++ +DG+T L +A G
Sbjct: 1020 ENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKG 1056
Score = 185 bits (469), Expect = 4e-46
Identities = 206/750 (27%), Positives = 310/750 (41%), Gaps = 88/750 (11%)
Query: 114 PLYMAAQENHLEVVKFLLENGANQ-----NVATEDGFTPLAVALQQGHENV----VAHLI 164
PL+ A + +VV L +Q N A +G L +AL + E++ V+H
Sbjct: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
Query: 165 NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP--NPDVLSKTGFTPLHIAAHY------ 216
+ K LH + D A L++N N L TPLH+ A Y
Sbjct: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQE-TPLHLVALYSSKKHS 339
Query: 217 -----ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN-VIMVRLLLDRGAQIETKTK 270
E +A+ LL GA+ N G TPLH++ GN + +LL + +E K
Sbjct: 340 ADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDH 399
Query: 271 DELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
+ T L A + H+ +S Q+ P+ D L+Q +
Sbjct: 400 EGSTALWLAVQ--HITVSSD--------QSVNPFEDVPVVNGTSFDENSFAARLIQRGSH 449
Query: 331 ID-DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMEL 389
D T L AA G+ A L GA N R G TPLH AC+ +
Sbjct: 450 TDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAE 509
Query: 390 LLKTGASIDAVTESGL-------------------TPLHVASFMGHLPIVKNLLQRGASP 430
LL+ GA+ + TE L TPLH+A H +V +L++ A+
Sbjct: 510 LLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANA 569
Query: 431 -------------NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477
++ + + +T L +A G +A LL + A +N D QT LH A
Sbjct: 570 LHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMA 629
Query: 478 ARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
+ + LLE+ A+ N++ T G T L +A R V A+ + A + +KG
Sbjct: 630 IQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKG 689
Query: 537 FTPLHVAAKYGKVRVAELLLER--DAHPNAAGKNGL--TPLHVAVHHNNLDIVKLLLPRG 592
PL +A +A L+ DA G G T LH A+ NN L+ G
Sbjct: 690 NPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSG 749
Query: 593 ---GSPHSPAWNG---------YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLH 640
SP P NG TPLH+AA E + LL++G + NA+ +G TP+H
Sbjct: 750 CDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIH 809
Query: 641 LAAQEGHAEMVALLLS-KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATT 698
+A H ++ LL+S + N+ ++ GLTP + A+ ++K +
Sbjct: 810 VAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVD 869
Query: 699 RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTK--LGYSPLHQAAQQGHTDIVTLLLKN 756
G LHVA +I+ V FL+ A+VN++ + +PLH A Q G IV LL
Sbjct: 870 NKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLA 929
Query: 757 GASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
GA NE++ T L +A + ++ VL
Sbjct: 930 GAKVNELTKHRQTALHLAAQQDLPTICSVL 959
Score = 152 bits (384), Expect = 3e-36
Identities = 161/619 (26%), Positives = 257/619 (41%), Gaps = 58/619 (9%)
Query: 18 RAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKK 77
RAA +GN AL NG +N N+ G LH A + G + ELL +
Sbjct: 464 RAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQ---------QG 514
Query: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
N L + L + +V+ Q TPL+MA NH +VV +LE AN
Sbjct: 515 ANPNLQTEEALPLPKEAASLTSLADSVHLQ-----TPLHMAIAYNHPDVVSVILEQKANA 569
Query: 138 NVATED-------------GFTPLAVALQQGHENVVAHLINYGTKGKVRL----PALHIA 180
AT + T L +AL G + A L+ G + LH+A
Sbjct: 570 LHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMA 629
Query: 181 ARNDDTRTAAVLLQNDPNPDV-LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
+ D+++A LL++ + +V ++ G T L +A + V + RGA ++ + G
Sbjct: 630 IQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKG 689
Query: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE----LTPLHCAARNGHVRISEILLDHG 295
PL +A + L+ G T LH A + + L+ G
Sbjct: 690 NPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSG 749
Query: 296 API------------QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLH 343
+ + + ++G +P+H+AA + V+ LL++ A ++ + TP+H
Sbjct: 750 CDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIH 809
Query: 344 VAAHCGHHRVAKVLLD-KGAKPNSRALNGFTPLHIACK-KNHVRVMELLLKTGASIDAVT 401
VA H + ++L+ N R G TP A KN+ +L + + + V
Sbjct: 810 VAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVD 869
Query: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPN--VSNVKVETPLHMAARAGHTEVAKYLLQN 459
G LHVA + V L+ A+ N V + TPLH+A +AG + + LL
Sbjct: 870 NKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLA 929
Query: 460 KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519
AKVN K QT LH AA+ + +LLEN + G+ LH+A G + +
Sbjct: 930 GAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNI 989
Query: 520 LALL-EKEASQACMTKKGFTPLHVAAKYGKVRVA---ELLLE-RDAHP-NAAGKNGLTPL 573
LL E +G +PLH+ +YGK A +L LE +P + +G T L
Sbjct: 990 RVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVL 1049
Query: 574 HVAVHHNNLDIVKLLLPRG 592
+A N ++ + ++ G
Sbjct: 1050 LLAYMKGNANLCRAIVRSG 1068
Score = 145 bits (366), Expect = 4e-34
Identities = 134/532 (25%), Positives = 232/532 (43%), Gaps = 35/532 (6%)
Query: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
++ + D + L + N A ++L+ D + + L LA G + +
Sbjct: 550 AIAYNHPDVVSVILE--QKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQ 607
Query: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQEN 122
LL + T G T LH+A + L+ + A++N +++Q G T L +A +
Sbjct: 608 LLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQ 667
Query: 123 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------ 176
VV + GA+ +V E G PL +AL E++ + L+ +G P
Sbjct: 668 LPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQ 727
Query: 177 --LHIAARNDDTRTAAVLLQ-----NDPNP-------DVLSKTGFTPLHIAAHYENLNVA 222
LH A ++ TA L++ N P + ++ G TPLH+AA +
Sbjct: 728 TLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETV 787
Query: 223 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR-GAQIETKTKDELTPLHCAAR 281
Q LL GA+VN G TP+H+A + ++++LL+ + + + LTP CA
Sbjct: 788 QCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMT 847
Query: 282 NGHVRISEILL--DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLD-- 337
+ + +E +L + GA Q K G + +H+A Q ++ V L+ A ++ D
Sbjct: 848 FKNNKSAEAILKRESGAAEQVDNK-GRNFLHVAVQNSDIESVLFLISVHANVNSRVQDAS 906
Query: 338 HLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI 397
LTPLH+A G + + LL GAK N + T LH+A +++ + +LL+ G
Sbjct: 907 KLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDF 966
Query: 398 DAVTESGLTPLHVASFMGHLPIVKNLL-QRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
AV E+G LH+A G L ++ LL + N++ ++PLH+ + G A
Sbjct: 967 AAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIF 1026
Query: 457 -----LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503
++ D T L A G+ N+ + ++ + A + G
Sbjct: 1027 DLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQG 1078
Score = 114 bits (285), Expect = 9e-25
Identities = 95/360 (26%), Positives = 161/360 (44%), Gaps = 42/360 (11%)
Query: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQKGF------------TPLYMAAQENHLEVV 127
T LH A + L+ G +VN+ Q G TPL++AA E V
Sbjct: 728 TLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETV 787
Query: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187
+ LLE GAN N +G TP+ VA+ H ++ L+++ P +H+ R+
Sbjct: 788 QCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSH--------PDIHLNVRDRQGL 839
Query: 188 T---AAVLLQNDPNPDVLSKT-----------GFTPLHIAAHYENLNVAQLLLNRGASVN 233
T A+ +N+ + + + K G LH+A ++ L++ A+VN
Sbjct: 840 TPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVN 899
Query: 234 FTPQNG--ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
Q+ +TPLH+A + G+ I+VR LL GA++ TK T LH AA+ I +L
Sbjct: 900 SRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVL 959
Query: 292 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLL-QYDAEIDDITLDHLTPLHVAAHCGH 350
L++G A +NG + +H+A L+ +R+LL + + + L +PLH+ G
Sbjct: 960 LENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGK 1019
Query: 351 HRVAKVL-----LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 405
A + G + +G T L +A K + + ++++GA + G+
Sbjct: 1020 ENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGV 1079
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 196 bits (498), Expect = 2e-49
Identities = 136/410 (33%), Positives = 204/410 (49%), Gaps = 9/410 (2%)
Query: 192 LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN 251
LL+ + D ++ G TPL IAA NL + + L+ GA+ N + T L AS+ G+
Sbjct: 24 LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGH 83
Query: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 311
V +V LL G +E + T L A G + E+LL HGA + PI
Sbjct: 84 VHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIW 143
Query: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371
AA H D V LLLQ A+++ TPL AA GH K LL GA + N
Sbjct: 144 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203
Query: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
T L +A K + + ++ +LK +++ + G T L +AS GH IV++LL G N
Sbjct: 204 MTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVN 263
Query: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
+ + +T L A R GH E+ + LLQ A ++ + +D++T L+ A G+ MV+ +L+
Sbjct: 264 IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQ 323
Query: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
N + + T G TPL A + ++E V LL+K A + + KKG TPLH+A + ++
Sbjct: 324 CNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKL 383
Query: 552 AELLLERDA------HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
AELLL PN AG+ TP ++ H + ++ R SP
Sbjct: 384 AELLLRNPKDGRLLYRPNKAGE---TPYNIDCSHQKSILTQIFGARHLSP 430
Score = 185 bits (469), Expect = 4e-46
Identities = 130/395 (32%), Positives = 197/395 (49%), Gaps = 3/395 (0%)
Query: 217 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276
EN+ + LL + V+ + G TPL IA+ +GN+ +V+ L+ GA + D T L
Sbjct: 16 ENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75
Query: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL 336
A++ GHV I E LL G ++ + G + + A D V LLL + A L
Sbjct: 76 ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135
Query: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
+ P+ AA GH + +LL GAK N G TPL A +K H+ ++ LL GA
Sbjct: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195
Query: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
+D + +T L VA G+ VK +L+R + N+++ T L +A++ GHTE+ + L
Sbjct: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
Query: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
L VN + T L A R GH +V+ LL+ A+ ++ T L+ A +G+
Sbjct: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
Query: 517 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576
V +L+ TK G TPL A K + V ELLL++ A +A K G TPLH+A
Sbjct: 316 TMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375
Query: 577 VHHNNLDIVKLLL--PRGGS-PHSPAWNGYTPLHI 608
+ + + +LLL P+ G + P G TP +I
Sbjct: 376 IRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNI 410
Score = 182 bits (463), Expect = 2e-45
Identities = 130/387 (33%), Positives = 192/387 (49%), Gaps = 3/387 (0%)
Query: 291 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGH 350
LL+ + + + G +P+ +AA+ +L+ V+ L++ A + LD+ T L A+ GH
Sbjct: 24 LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGH 83
Query: 351 HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV 410
+ + LL G R + G+T L AC K V+ELLL GA+ + P+
Sbjct: 84 VHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIW 143
Query: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470
A+ GH IV LLQ GA N S+ TPL AAR GH E K+LL A V+ + +
Sbjct: 144 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203
Query: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530
T L A + G+T VK +L+ N N NL G+T L IA++EGH E V LL+
Sbjct: 204 MTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVN 263
Query: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590
+ G T L A + G V + LL++ A + G++ T L+ AV N +V+ +L
Sbjct: 264 IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQ 323
Query: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
+G TPL A K +EV LL G +A +G TPLH+A + ++
Sbjct: 324 CNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKL 383
Query: 651 VALLLSKQANGNL---GNKSGLTPLHL 674
LLL +G L NK+G TP ++
Sbjct: 384 AELLLRNPKDGRLLYRPNKAGETPYNI 410
Score = 178 bits (451), Expect = 5e-44
Identities = 126/412 (30%), Positives = 206/412 (50%), Gaps = 4/412 (0%)
Query: 316 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL 375
+++ ++ LL+ ++D+ TPL +AA G+ + K L+ GA N L+ +T L
Sbjct: 16 ENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75
Query: 376 HIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNV 435
A K+ HV ++E LLK G +++ G T L A + G +V+ LL GA+P+V+ +
Sbjct: 76 ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135
Query: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495
P+ AA GH ++ LLQN AKVN K TPL AAR GH VK LL A+
Sbjct: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195
Query: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555
+ T L +A + G+ ++V +L++ + K G T L +A+K G + + L
Sbjct: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
Query: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615
L+ + N ++G T L AV +++IV+ LL + + T L+ A ++
Sbjct: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
Query: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675
+ R +LQ + G TPL A + + E+V LLL K A + +K G TPLH+
Sbjct: 316 TMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375
Query: 676 AQEGHVPVADVLI---KHGVMVDATTRMGYTPLHV-ASHYGNIKLVKFLLQH 723
+ +A++L+ K G ++ + G TP ++ SH +I F +H
Sbjct: 376 IRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARH 427
Score = 172 bits (437), Expect = 2e-42
Identities = 119/377 (31%), Positives = 190/377 (50%)
Query: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439
++ ++ ++ LL+ +D E G TPL +A+ G+L IVK L++ GA+ N+ ++ T
Sbjct: 14 EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
Query: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 499
L A++ GH + + LL+ + + T L A G T++V+LLL + ANP++
Sbjct: 74 ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
Query: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 559
P+ AA GH + V LL+ A C K G TPL AA+ G + + LL
Sbjct: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193
Query: 560 AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR 619
A + G N +T L VAV VK +L R + + +G T L IA+K+ E+ +
Sbjct: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
Query: 620 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEG 679
LL G N G T L A + GH E+V LL K A+ ++ + T L+ ++G
Sbjct: 254 DLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKG 313
Query: 680 HVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLH 739
+ + +++ + T+ G TPL A+ NI++V+ LL A V+A K G +PLH
Sbjct: 314 NATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLH 373
Query: 740 QAAQQGHTDIVTLLLKN 756
A + + LLL+N
Sbjct: 374 IAIRGRSRKLAELLLRN 390
Score = 172 bits (437), Expect = 2e-42
Identities = 126/419 (30%), Positives = 204/419 (48%), Gaps = 32/419 (7%)
Query: 94 VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQ 153
++ L+ +V+ +++ G TPL +AA++ +LE+VK L++NGAN N+ D +T L A +
Sbjct: 21 LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80
Query: 154 QGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 213
+GH ++V L+ G N + G+T L A
Sbjct: 81 EGHVHIVEELLKCGV-----------------------------NLEHRDMGGWTALMWA 111
Query: 214 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 273
+ +V +LLL+ GA+ + T + P+ A+ RG+ +V LLL GA++ K
Sbjct: 112 CYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGT 171
Query: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
TPL AAR GH+ + LL GA + + N ++ + +A +G + V+ +L+ + ++
Sbjct: 172 TPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNL 231
Query: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
D T L +A+ GH + + LLD G N +G T L A + HV ++ LL+
Sbjct: 232 TDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQK 291
Query: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 453
A ID + T L+ A G+ +V+++LQ + ETPL A + + EV
Sbjct: 292 YADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVV 351
Query: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL---ATTAGHTPLHI 509
+ LL AKV+A K TPLH A R + +LLL N + L AG TP +I
Sbjct: 352 ELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNI 410
Score = 172 bits (435), Expect = 4e-42
Identities = 121/376 (32%), Positives = 191/376 (50%), Gaps = 13/376 (3%)
Query: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
T + AA GNL+ + ++NG + N + + L ASKEGHV +V ELL + LE
Sbjct: 40 TPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEH 99
Query: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
G TAL A G+ +VV L+++GAN + P+ AA H ++V LL+N
Sbjct: 100 RDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQN 159
Query: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTA 189
GA N + + G TPL A ++GH V HL+ G +G + AL +A + T++
Sbjct: 160 GAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSV 219
Query: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
+L+ +PN ++ K G T L IA+ + + Q LL+ G VN ++G T L A R
Sbjct: 220 KEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRG 279
Query: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309
G+V +VR LL + A I+ + +D T L+ A G+ + +L + TK+G +P+
Sbjct: 280 GHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPL 339
Query: 310 HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA------K 363
A + +++ V LLL A++ + TPLH+A ++A++LL +
Sbjct: 340 IKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYR 399
Query: 364 PNSRALNGFTPLHIAC 379
PN G TP +I C
Sbjct: 400 PNKA---GETPYNIDC 412
Score = 166 bits (419), Expect = 3e-40
Identities = 127/415 (30%), Positives = 198/415 (47%), Gaps = 3/415 (0%)
Query: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414
K LL+K + R G TPL IA ++ ++ +++ L+K GA+ + T L AS
Sbjct: 22 KALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKE 81
Query: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474
GH+ IV+ LL+ G + ++ T L A G T+V + LL + A + P+
Sbjct: 82 GHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPI 141
Query: 475 HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK 534
AA GH ++V LLL+N A N + G TPL AAR+GH+E V LL A
Sbjct: 142 IWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGA 201
Query: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
T L VA K G + + +L+R+ + N K+G T L +A + +IV+ LL G
Sbjct: 202 NSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTY 261
Query: 595 PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
+ P +G T L A + VE+ R+LLQ + T L+ A ++G+A MV +
Sbjct: 262 VNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDI 321
Query: 655 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNI 714
L + + K G TPL + ++ V ++L+ G V A + G TPLH+A +
Sbjct: 322 LQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSR 381
Query: 715 KLVKFLLQHQAD---VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766
KL + LL++ D + K G +P + + + + SP E D
Sbjct: 382 KLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGD 436
Score = 161 bits (408), Expect = 5e-39
Identities = 118/363 (32%), Positives = 179/363 (49%), Gaps = 6/363 (1%)
Query: 54 KEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFT 113
+E ++ + LL K ++ + G T L IAA G E+V+EL+ GAN N + +T
Sbjct: 14 EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
Query: 114 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173
L A++E H+ +V+ LL+ G N G+T L A +G +VV L+++G V
Sbjct: 74 ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
Query: 174 -----LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228
P + A R +LLQN + K G TPL AA +L + LL
Sbjct: 134 GLYSVYPIIWAAGRG-HADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAM 192
Query: 229 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
GA V+ N +T L +A + G V+ +L R + KD T L A++ GH I
Sbjct: 193 GADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIV 252
Query: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348
+ LLD G + ++G + + A +G H++ VR LLQ A+ID D+ T L+ A
Sbjct: 253 QDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEK 312
Query: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
G+ + + +L +G TPL A K ++ V+ELLL GA + AV + G TPL
Sbjct: 313 GNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPL 372
Query: 409 HVA 411
H+A
Sbjct: 373 HIA 375
Score = 161 bits (408), Expect = 5e-39
Identities = 114/361 (31%), Positives = 174/361 (48%)
Query: 416 HLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH 475
++P +K LL++ + N +TPL +AA G+ E+ K L++N A N + D+ T L
Sbjct: 17 NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
Query: 476 CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK 535
A++ GH ++V+ LL+ N G T L A +G + V LL A+ +
Sbjct: 77 SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
Query: 536 GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
P+ AA G + LLL+ A N + K G TPL A +L+ VK LL G
Sbjct: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
Query: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
N T L +A K + + +L+ + N G T L +A++EGH E+V LL
Sbjct: 197 DQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLL 256
Query: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
N+ ++SG T L + GHV + L++ +D + T L+ A GN
Sbjct: 257 DAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNAT 316
Query: 716 LVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
+V+ +LQ D TK G +PL +A + + ++V LLL GA + V G TPL IA
Sbjct: 317 MVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAI 376
Query: 776 R 776
R
Sbjct: 377 R 377
Score = 160 bits (404), Expect = 1e-38
Identities = 124/447 (27%), Positives = 201/447 (44%), Gaps = 34/447 (7%)
Query: 120 QENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHI 179
+E ++ +K LLE + + E G TPL +A +QG+ +V LI
Sbjct: 14 EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELI--------------- 58
Query: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
+N N ++ +T L A+ ++++ + LL G ++ G
Sbjct: 59 --------------KNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG 104
Query: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
T L A +G +V LLL GA + P+ AA GH I +LL +GA +
Sbjct: 105 WTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVN 164
Query: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
K G +P+ AA+ HL+CV+ LL A++D + +T L VA G+ + K +L
Sbjct: 165 CSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILK 224
Query: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
+ N +G T L IA K+ H +++ LL G ++ SG T L A GH+ I
Sbjct: 225 RNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEI 284
Query: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
V+ LLQ+ A ++ +T L+ A G+ + + +LQ KD +TPL A +
Sbjct: 285 VRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATK 344
Query: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM----TKK 535
+ + +V+LLL+ A + G TPLHIA R G + LL + + K
Sbjct: 345 MRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIR-GRSRKLAELLLRNPKDGRLLYRPNKA 403
Query: 536 GFTPLHVAAKYGKVRVAELLLERDAHP 562
G TP ++ + K + ++ R P
Sbjct: 404 GETPYNIDCSHQKSILTQIFGARHLSP 430
Score = 159 bits (401), Expect = 3e-38
Identities = 107/333 (32%), Positives = 168/333 (50%)
Query: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAARE 513
K LL+ V+ + + QTPL AA G+ +VK L++N AN NL T L A++E
Sbjct: 22 KALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKE 81
Query: 514 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 573
GHV V LL+ + G+T L A G+ V ELLL A+P+ G + P+
Sbjct: 82 GHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPI 141
Query: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 633
A + DIV LLL G + G TPL AA++ +E + LL G + E
Sbjct: 142 IWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGA 201
Query: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693
+T L +A + G+ + V +L + N NL +K G T L + ++EGH + L+ G
Sbjct: 202 NSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTY 261
Query: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
V+ R G T L A G++++V+ LLQ AD++ + + + L+ A ++G+ +V +
Sbjct: 262 VNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDI 321
Query: 754 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
L+ + DG TPL A ++ I V ++L
Sbjct: 322 LQCNPDTEICTKDGETPLIKATKMRNIEVVELL 354
Score = 97.1 bits (240), Expect = 1e-19
Identities = 59/170 (34%), Positives = 92/170 (54%)
Query: 611 KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLT 670
++ + ++LL+ + + G TPL +AA++G+ E+V L+ AN NL + T
Sbjct: 14 EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
Query: 671 PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 730
L ++EGHV + + L+K GV ++ G+T L A + G +V+ LL H A+ +
Sbjct: 74 ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
Query: 731 TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780
P+ AA +GH DIV LLL+NGA N GTTPL A R G++
Sbjct: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHL 183
Score = 94.0 bits (232), Expect = 1e-18
Identities = 63/222 (28%), Positives = 113/222 (50%), Gaps = 7/222 (3%)
Query: 10 ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI 69
A++ T+ + A + G + L+ ++N +++G L +ASKEGH ++V +LL
Sbjct: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260
Query: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129
+ + G+T L A G E+VR L+ A+++ + Q T LY A ++ + +V+
Sbjct: 261 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 320
Query: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDD 185
+L+ + + T+DG TPL A + + VV L++ G K K LHIA R
Sbjct: 321 ILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRS 380
Query: 186 TRTAAVLLQNDPNPDVL---SKTGFTPLHIAAHYENLNVAQL 224
+ A +LL+N + +L +K G TP +I ++ + Q+
Sbjct: 381 RKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQI 422
Score = 65.9 bits (159), Expect = 4e-10
Identities = 50/189 (26%), Positives = 91/189 (48%), Gaps = 12/189 (6%)
Query: 644 QEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYT 703
+E + + LL K + + N+ G TPL + A++G++ + LIK+G + +T
Sbjct: 14 EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
Query: 704 PLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEV 763
L AS G++ +V+ LL+ ++ + G++ L A +G TD+V LLL +GA+P+
Sbjct: 74 ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
Query: 764 SSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKH---------RMSFPETVDEIL 814
P+ A G+ D++ ++ + V SDK+ R E V +L
Sbjct: 134 GLYSVYPIIWAAGRGH---ADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLL 190
Query: 815 DVSEDEGEE 823
+ D +E
Sbjct: 191 AMGADVDQE 199
Score = 56.6 bits (135), Expect = 2e-07
Identities = 39/129 (30%), Positives = 63/129 (48%)
Query: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
V + T + A R G+++ L+ DI+ Q+ L+ A ++G+ MV ++
Sbjct: 262 VNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDI 321
Query: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
L E TK G T L A EVV L++ GA V+A +KG TPL++A +
Sbjct: 322 LQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSR 381
Query: 125 EVVKFLLEN 133
++ + LL N
Sbjct: 382 KLAELLLRN 390
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 191 bits (486), Expect = 4e-48
Identities = 121/334 (36%), Positives = 177/334 (52%), Gaps = 5/334 (1%)
Query: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
LH+A A LL N+ NP++ ++ G TPLH+A V +LLL R SVN
Sbjct: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501
Query: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296
++ T LH A++ G+ RLLL++ A + + TP+H A ++G I ILL G
Sbjct: 502 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGV 561
Query: 297 PIQAKTKNGLSPIHMAAQGDHLDCVRLLL-QYDAEIDDITLDHLTPLHVAAHCGHHRVAK 355
+ + K+ P+H AA HL V+LL Q ++ TLD TPLH+AA GH+RVA+
Sbjct: 562 DVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVAR 621
Query: 356 VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMG 415
+L+D + N +L TPLH+A + H LLL GA +A+T G T LH+A+ G
Sbjct: 622 ILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNG 681
Query: 416 HLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH 475
HL VK L++ A +T LH+AA GH+EV + L+ ++ + + LH
Sbjct: 682 HLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALH 740
Query: 476 CAARIGHTNMVKLLLENNANPNLAT---TAGHTP 506
AA+ H V+ LL + A+ NL + GH P
Sbjct: 741 LAAQGRHAQTVETLLRHGAHINLQSLKFQGGHGP 774
Score = 186 bits (471), Expect = 2e-46
Identities = 122/361 (33%), Positives = 178/361 (49%), Gaps = 10/361 (2%)
Query: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
+D +SG + LH+A G K LL A+PN+SN + TPLHMA V + L
Sbjct: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490
Query: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
L K VNAK +D T LH AA+ G + +LLLE NA+ N G TP+H+A + G
Sbjct: 491 LARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQE 550
Query: 517 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER-DAHPNAAGKNGLTPLHV 575
V LL + + K + PLH AA G + + +LL ++ NA +G TPLH+
Sbjct: 551 NIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHL 610
Query: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
A + + ++L+ + + TPLH+AA+ AR LL G A + G
Sbjct: 611 AAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDG 670
Query: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
T LHLAA+ GH V LL+ ++A+ T LHL A GH V + L+ V +D
Sbjct: 671 YTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-ID 729
Query: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755
G + LH+A+ + + V+ LL+H A +N ++ Q GH TLL +
Sbjct: 730 LFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQS--------LKFQGGHGPAATLLRR 781
Query: 756 N 756
+
Sbjct: 782 S 782
Score = 184 bits (466), Expect = 9e-46
Identities = 116/322 (36%), Positives = 166/322 (51%), Gaps = 2/322 (0%)
Query: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
LH+A AG E AK+LL N A N + TPLH A +V+LLL + N
Sbjct: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501
Query: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560
T LH AA+ G + LLEK AS + +G TP+HVA ++G+ + +LL R
Sbjct: 502 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGV 561
Query: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG-SPHSPAWNGYTPLHIAAKQNQVEVAR 619
+ GK+ PLH A +L IVKLL + G S ++ +G TPLH+AA++ VAR
Sbjct: 562 DVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVAR 621
Query: 620 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEG 679
L+ N S+ TPLH+AA+ GH LLL + A G T LHL A+ G
Sbjct: 622 ILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNG 681
Query: 680 HVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLH 739
H+ +L++ V A + T LH+A+ +G+ ++V+ L+ ++ + G S LH
Sbjct: 682 HLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALH 740
Query: 740 QAAQQGHTDIVTLLLKNGASPN 761
AAQ H V LL++GA N
Sbjct: 741 LAAQGRHAQTVETLLRHGAHIN 762
Score = 182 bits (461), Expect = 3e-45
Identities = 110/333 (33%), Positives = 168/333 (50%), Gaps = 2/333 (0%)
Query: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
V+ +G + LH+A G + LL A + TPLH A + E+L
Sbjct: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490
Query: 292 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH 351
L + AK ++ + +H AAQ RLLL+ +A ++++ + TP+HVA G
Sbjct: 491 LARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQE 550
Query: 352 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT-GASIDAVTESGLTPLHV 410
+ ++LL +G + + + + PLH A + H+ +++LL K G S++A T G TPLH+
Sbjct: 551 NIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHL 610
Query: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470
A+ GH + + L+ + NV ++ +TPLH+AA GHT A+ LL A A D
Sbjct: 611 AAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDG 670
Query: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530
T LH AAR GH VKLL+E A+ T LH+AA GH E V L+ +
Sbjct: 671 YTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVID- 729
Query: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
++G + LH+AA+ + E LL AH N
Sbjct: 730 LFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
Score = 181 bits (458), Expect = 8e-45
Identities = 119/344 (34%), Positives = 179/344 (52%), Gaps = 3/344 (0%)
Query: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
DT +LQ + D+ +G + LH+A A+ LL A+ N + + G TPLH
Sbjct: 418 DTSKLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLH 476
Query: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
+A R +V LLL R + K +D+ T LH AA+NG + +LL+ A +
Sbjct: 477 MAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFE 536
Query: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK-GAK 363
G +P+H+A Q + VR+LL+ ++ D PLH AA GH + K+L + G
Sbjct: 537 GRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVS 596
Query: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
N++ L+G TPLH+A ++ H RV +L+ + ++ + TPLHVA+ GH + L
Sbjct: 597 VNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLL 656
Query: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
L RGA T LH+AAR GH K L++ KA V A+ +QT LH AA GH+
Sbjct: 657 LHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHS 716
Query: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527
+V+ L+ + +L G + LH+AA+ H +TV LL A
Sbjct: 717 EVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759
Score = 169 bits (429), Expect = 2e-41
Identities = 105/318 (33%), Positives = 171/318 (53%), Gaps = 18/318 (5%)
Query: 536 GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
G + LH+A + G+ A+ LL +A+PN + + G TPLH+AV +V+LLL R S
Sbjct: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 497
Query: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
++ + +T LH AA+ R LL+ S N +G TP+H+A Q G +V +LL
Sbjct: 498 NAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILL 557
Query: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH-GVMVDATTRMGYTPLHVASHYGNI 714
+ + +L K PLH A +GH+P+ +L K GV V+A T G TPLH+A+ G+
Sbjct: 558 RRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHY 617
Query: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
++ + L+ +DVN + L +PLH AA+ GHT LLL GA ++SDG T L +A
Sbjct: 618 RVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLA 677
Query: 775 KRLGYISVTDVLKVVTDETSFVL-------------VSDKHRMSFPETVD-EILDVSEDE 820
R G+++ +K++ +E + VL + H E V +++D+ +++
Sbjct: 678 ARNGHLA---TVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVIDLFDEQ 734
Query: 821 GEELISFKAERRDSRDVD 838
G + A+ R ++ V+
Sbjct: 735 GLSALHLAAQGRHAQTVE 752
Score = 155 bits (393), Expect = 3e-37
Identities = 118/354 (33%), Positives = 175/354 (49%), Gaps = 9/354 (2%)
Query: 22 SGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTA 81
SG+ K + L+ D++ +G + LHLA + G + LL + ++G+T
Sbjct: 416 SGDTSKLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTP 474
Query: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
LH+A VV L+ +VNA+ + +T L+ AAQ + LLE A+ N
Sbjct: 475 LHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVD 534
Query: 142 EDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTAAVLLQNDP 197
+G TP+ VA Q G EN+V L+ G +GK LH AA LL P
Sbjct: 535 FEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHL-PIVKLLAKQP 593
Query: 198 NPDVLSKT--GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV 255
V ++T G TPLH+AA + VA++L++ + VN TPLH+A+ G+
Sbjct: 594 GVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTA 653
Query: 256 RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315
RLLL RGA E T D T LH AARNGH+ ++L++ A + A+ + +H+AA
Sbjct: 654 RLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAH 713
Query: 316 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369
H + V L+ D ID L+ LH+AA H + + LL GA N ++L
Sbjct: 714 GHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSL 766
Score = 152 bits (383), Expect = 4e-36
Identities = 109/329 (33%), Positives = 168/329 (51%), Gaps = 9/329 (2%)
Query: 11 DAATSFLR-AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL-HKE 68
D+ S L A +G + A L N + N N+ G LH+A E V+ VVELL ++
Sbjct: 436 DSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAV-ERRVRGVVELLLARK 494
Query: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
I + + TALH AA G + R L+ A+VN +G TP+++A Q +V+
Sbjct: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554
Query: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHL-----INYGTKGKVRLPALHIAARN 183
LL G + ++ +D + PL A QGH +V L ++ + LH+AA+
Sbjct: 555 ILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQR 614
Query: 184 DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPL 243
R A +L+ + +V S TPLH+AA + + A+LLL+RGA +G T L
Sbjct: 615 GHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTAL 674
Query: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
H+A+R G++ V+LL++ A + + T LH AA +GH + E L+ I +
Sbjct: 675 HLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDE 733
Query: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
GLS +H+AAQG H V LL++ A I+
Sbjct: 734 QGLSALHLAAQGRHAQTVETLLRHGAHIN 762
Score = 104 bits (259), Expect = 9e-22
Identities = 78/272 (28%), Positives = 132/272 (48%), Gaps = 8/272 (2%)
Query: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
SV ++ D T+ AA++G+ L +N + G +H+A + G +V
Sbjct: 496 SVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRI 555
Query: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNY-GANVNAQSQKGFTPLYMAAQEN 122
LL + + + K LH AA G +V+ L G +VNAQ+ G TPL++AAQ
Sbjct: 556 LLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRG 615
Query: 123 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRL-----PAL 177
H V + L++ ++ NV + TPL VA + GH + L++ G GK + AL
Sbjct: 616 HYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGA-GKEAMTSDGYTAL 674
Query: 178 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ 237
H+AARN T +L++ + T LH+AA + + V + L++ ++ +
Sbjct: 675 HLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDE 733
Query: 238 NGITPLHIASRRGNVIMVRLLLDRGAQIETKT 269
G++ LH+A++ + V LL GA I ++
Sbjct: 734 QGLSALHLAAQGRHAQTVETLLRHGAHINLQS 765
Score = 68.9 bits (167), Expect = 4e-11
Identities = 43/125 (34%), Positives = 65/125 (52%)
Query: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721
+L SG + LHL + G A L+ + + + R G TPLH+A +V+ LL
Sbjct: 432 DLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLL 491
Query: 722 QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYIS 781
+ VNAK + ++ LH AAQ G LLL+ AS NEV +G TP+ +A + G +
Sbjct: 492 ARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQEN 551
Query: 782 VTDVL 786
+ +L
Sbjct: 552 IVRIL 556
Score = 52.0 bits (123), Expect = 5e-06
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 1/101 (0%)
Query: 10 ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI 69
+D T+ AAR+G+L + D+ LHLA+ GH ++V EL+ ++
Sbjct: 668 SDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV 727
Query: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 110
I + ++G +ALH+AA + V L+ +GA++N QS K
Sbjct: 728 I-DLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLK 767
Score = 45.4 bits (106), Expect = 5e-04
Identities = 31/93 (33%), Positives = 44/93 (47%)
Query: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
VD G + LH+A G + K+LL + A+ N + G +PLH A ++ +V LL
Sbjct: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490
Query: 754 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
L S N D T L A + G S T +L
Sbjct: 491 LARKISVNAKDEDQWTALHFAAQNGDESSTRLL 523
Score = 36.6 bits (83), Expect = 0.24
Identities = 27/72 (37%), Positives = 38/72 (52%), Gaps = 2/72 (2%)
Query: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
KL+K +LQ Q DV+ G S LH A + G + LL N A+PN + G+TPL +A
Sbjct: 421 KLMK-ILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMA 478
Query: 775 KRLGYISVTDVL 786
V ++L
Sbjct: 479 VERRVRGVVELL 490
>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
Length = 1119
Score = 187 bits (476), Expect = 6e-47
Identities = 152/536 (28%), Positives = 253/536 (47%), Gaps = 30/536 (5%)
Query: 82 LHIAALAGQDEVVRELVNYGAN--VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
LH AA GQ E++ ++ + ++ G TPL+ A ++N +E VKFLL GAN N+
Sbjct: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
Query: 140 ATEDGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRTAAVLLQ 194
+ PL +A+Q + V+ L+ + T +G+ A+ IA +++ +LL+
Sbjct: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
Query: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS--------VNFTPQNGITPLHIA 246
P +K G P+H AA + +++L G +NF TPLH+A
Sbjct: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
Query: 247 SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD--HGAPIQAKTKN 304
+ G++ M+++ LD GAQI+ K T +H AA G I ++++ G+ T +
Sbjct: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
Query: 305 GL--SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
G + +H A+ DH + L+ A+I+ I + +PL +A + +LL KGA
Sbjct: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366
Query: 363 KPNSRALNGFTPLHIACK-----KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHL 417
+ + + G LH+ + KN + + + G TPLH A G
Sbjct: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGP 426
Query: 418 PIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD---QTPL 474
V NLL S + + ++PLH AA G + LLQ+ + + D TPL
Sbjct: 427 GSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPL 486
Query: 475 HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMT 533
H AA+ GH +V+LLL+ A L+ G T LH A+ G+ +T+ +L+ +
Sbjct: 487 HLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLD 545
Query: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
+ G T LH AA+ G + LLL +A K + LH+A+H+ ++V ++
Sbjct: 546 EDGNTALHFAAREGHAKAVALLLSHNA-DIVLNKQQASFLHLALHNKRKEVVLTII 600
Score = 180 bits (457), Expect = 1e-44
Identities = 155/547 (28%), Positives = 243/547 (44%), Gaps = 44/547 (8%)
Query: 243 LHIASRRGNV-IMVRLLLDRGAQIETKTKDE-LTPLHCAARNGHVRISEILLDHGAPIQA 300
LH A+ G + +M ++ D ++ + D TPLHCA + + LL GA
Sbjct: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
Query: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHHRVAKVL 357
+ N ++P+H+A QG + + +++LL++ D+ L+ T + +A + ++L
Sbjct: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEH--RTIDVNLEGENGNTAVIIACTTNNSEALQIL 184
Query: 358 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS--------IDAVTESGLTPLH 409
L KGAKP G P+H A ME++L+ G I+ + TPLH
Sbjct: 185 LKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLH 244
Query: 410 VASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK----VNA 465
+A G L ++K L GA + T +H AA G TE+ K ++ + + VN
Sbjct: 245 LAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNT 304
Query: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525
+T LH A+ H + L+ A+ N + G +PL +A V LL K
Sbjct: 305 TDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSK 364
Query: 526 EASQACMTKKGFTPLHVAAK--YG----------KVRVAELLLERDAHPNAAGKNGLTPL 573
A G LH+ + YG ++ EL+++ D +G TPL
Sbjct: 365 GAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDED-------NDGCTPL 417
Query: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA---NA 630
H A V LL S HS + + +PLH AA ++ + LLQ N
Sbjct: 418 HYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNE 477
Query: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
+ G+TPLHLAA+ GH ++V LLL K A L + +G T LH + G+ V++
Sbjct: 478 GDLHGMTPLHLAAKNGHDKVVQLLLKKGALF-LSDHNGWTALHHASMGGYTQTMKVILDT 536
Query: 691 GVM-VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
+ D G T LH A+ G+ K V LL H AD+ K S LH A ++
Sbjct: 537 NLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALHNKRKEV 595
Query: 750 VTLLLKN 756
V ++++
Sbjct: 596 VLTIIRS 602
Score = 174 bits (441), Expect = 7e-43
Identities = 152/518 (29%), Positives = 235/518 (45%), Gaps = 47/518 (9%)
Query: 276 LHCAARNGHVRISE-ILLDHGAPIQAKTKN-GLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
LH AA G + + E I D + + + G +P+H A + + ++ V+ LL A +
Sbjct: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
Query: 334 ITLDHLTPLHVAAHCGHHRVAKVLLD-KGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392
+ + PLH+A ++ V KVLL+ + N NG T + IAC N+ +++LLK
Sbjct: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
Query: 393 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP--------NVSNVKVETPLHMA 444
GA + G P+H A+F G ++ +L+ G N N TPLH+A
Sbjct: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
Query: 445 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP----NLAT 500
+ G E+ K L N A+++ K T +H AA G T +VKL++ + + N
Sbjct: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
Query: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560
T LH A+ H E L+ A + +G +PL +A + LLL + A
Sbjct: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366
Query: 561 HPNAAGKNGLTPLHVAVHH----NNL--------DIVKLLLPRGGSPHSPAWNGYTPLHI 608
+ G LH+ V NL I +L++ +G TPLH
Sbjct: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDN-------DGCTPLHY 419
Query: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL---GN 665
A +Q +LL + S +++S +PLH AA G LL ++ L G+
Sbjct: 420 ACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGD 479
Query: 666 KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
G+TPLHL A+ GH V +L+K G + + G+T LH AS G + +K +L
Sbjct: 480 LHGMTPLHLAAKNGHDKVVQLLLKKGALF-LSDHNGWTALHHASMGGYTQTMKVIL---- 534
Query: 726 DVNAKT-----KLGYSPLHQAAQQGHTDIVTLLLKNGA 758
D N K + G + LH AA++GH V LLL + A
Sbjct: 535 DTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNA 572
Score = 174 bits (440), Expect = 1e-42
Identities = 151/509 (29%), Positives = 234/509 (45%), Gaps = 30/509 (5%)
Query: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD-RGAQ 264
G TPLH A + + LL+RGA+ N N + PLHIA + N ++++LL+ R
Sbjct: 98 GNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTID 157
Query: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
+ + ++ T + A + +ILL GA K G PIH AA +C+ ++
Sbjct: 158 VNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEII 217
Query: 325 LQYDAE--------IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376
L++ E I+ + TPLH+A G + K+ LD GA+ + T +H
Sbjct: 218 LRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIH 277
Query: 377 IACKKNHVRVMELLLKT-GASIDAV-TESGL--TPLHVASFMGHLPIVKNLLQRGASPNV 432
A + +++L++ + S+D V T G T LH AS H + L+ GA N
Sbjct: 278 FAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINK 337
Query: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR--IGHTNMVKLLL 490
+ + +PL +A + + LL A+V+ K + LH + G N+ +
Sbjct: 338 IDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFM 397
Query: 491 ENNANPNLATTA---GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 547
+ L G TPLH A R+G +V LL S +K +PLH AA YG
Sbjct: 398 QMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYG 457
Query: 548 KVRVAELLLERDAHP---NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG---SPHSPAWN 601
++ + LL+ + N +G+TPLH+A + + +V+LLL +G S H N
Sbjct: 458 RINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDH----N 513
Query: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAE-SVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
G+T LH A+ + + +L G T LH AA+EGHA+ VALLLS A+
Sbjct: 514 GWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNAD 573
Query: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
L NK + LHL V +I+
Sbjct: 574 IVL-NKQQASFLHLALHNKRKEVVLTIIR 601
Score = 149 bits (377), Expect = 2e-35
Identities = 133/473 (28%), Positives = 208/473 (43%), Gaps = 60/473 (12%)
Query: 375 LHIACKKNHVRVMELLLKTGAS--IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
LH A + + +ME + + + + + + G TPLH A + VK LL RGA+PN+
Sbjct: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
Query: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKA-KVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
N + PLH+A + + EV K LL+++ VN + ++ T + A ++ +++LL+
Sbjct: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
Query: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALL--------EKEASQACMTKKGFTPLHVA 543
A P + G P+H AA G E + +L ++ M TPLH+A
Sbjct: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
Query: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP--RGGSPHSPAWN 601
+ G + + ++ L+ A + K T +H A +IVKL++ G +
Sbjct: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
Query: 602 G--YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
G T LH A+ + E+A L+ G N +G +PL LA +V LLLSK A
Sbjct: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366
Query: 660 ----NGNLG----------------------------------NKSGLTPLHLVAQEGHV 681
N G + G TPLH ++G
Sbjct: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGP 426
Query: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD---VNAKTKLGYSPL 738
+ L+ V + + ++ +PLH A+ YG I + LLQ +D +N G +PL
Sbjct: 427 GSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPL 486
Query: 739 HQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTD 791
H AA+ GH +V LLLK GA +G T L A GY T +KV+ D
Sbjct: 487 HLAAKNGHDKVVQLLLKKGALFLS-DHNGWTALHHASMGGY---TQTMKVILD 535
Score = 141 bits (356), Expect = 5e-33
Identities = 127/450 (28%), Positives = 207/450 (46%), Gaps = 27/450 (6%)
Query: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
+D+N +NG + +A + + + LL K + K G +H AA +G E +
Sbjct: 156 IDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECME 215
Query: 96 ELVNYG--------ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 147
++ +G ++N + TPL++A Q LE++K L+NGA + + T
Sbjct: 216 IILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTA 275
Query: 148 LAVALQQGHENVVAHLIN--------YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
+ A QG +V +I+ T LH A+ D A L+ +
Sbjct: 276 IHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADI 335
Query: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG-NVIMVRLL 258
+ + G +PL +A + N+ LLL++GA V+ G LH+ ++ + +R
Sbjct: 336 NKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPE 395
Query: 259 LDRGAQIETKTKDE----LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQ 314
+ QI+ DE TPLH A R G LL I +K+K+ SP+H AA
Sbjct: 396 FMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAAS 455
Query: 315 GDHLDCVRLLLQYDAE---IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371
++ + LLQ ++ +++ L +TPLH+AA GH +V ++LL KGA S NG
Sbjct: 456 YGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDH-NG 514
Query: 372 FTPLHIACKKNHVRVMELLLKTGAS-IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
+T LH A + + M+++L T D + E G T LH A+ GH V LL A
Sbjct: 515 WTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNAD- 573
Query: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNK 460
V N + + LH+A EV ++++K
Sbjct: 574 IVLNKQQASFLHLALHNKRKEVVLTIIRSK 603
Score = 112 bits (279), Expect = 4e-24
Identities = 101/372 (27%), Positives = 159/372 (42%), Gaps = 52/372 (13%)
Query: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGH---VKMV 61
+ F AT A ++G+L+ L NG I+ + +H A+ +G VK++
Sbjct: 232 INFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLM 291
Query: 62 VELLHKEI-ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
+ + I+ TT T LH A+L E+ L++ GA++N +G +PL +A
Sbjct: 292 ISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATA 351
Query: 121 ENHLEVVKFLLENGANQNV--------------------------------------ATE 142
+V LL GA ++
Sbjct: 352 SASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDN 411
Query: 143 DGFTPLAVALQQGHENVVAHLINYG----TKGKVRLPALHIAARNDDTRTAAVLLQNDPN 198
DG TPL A +QG V +L+ + +K K + LH AA T LLQ+ +
Sbjct: 412 DGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISD 471
Query: 199 PDVLSK---TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV 255
+L++ G TPLH+AA + V QLLL +GA + + NG T LH AS G +
Sbjct: 472 TRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTM 530
Query: 256 RLLLDRGAQIETK-TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQ 314
+++LD + + +D T LH AAR GH + +LL H A I K S +H+A
Sbjct: 531 KVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALH 589
Query: 315 GDHLDCVRLLLQ 326
+ V +++
Sbjct: 590 NKRKEVVLTIIR 601
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 182 bits (461), Expect = 3e-45
Identities = 136/400 (34%), Positives = 201/400 (50%), Gaps = 17/400 (4%)
Query: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308
G+V VR LLD G + T++ + L A G+ ++++LL A ++ + G ++P
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
Query: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
+ A+ G +LD V+LLL +DA+++ + T L A G + KVLL++GA
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424
NG TPL A HV V +LL GA I+ + ES LT +A + GHL +V+ LL
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
Query: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
+ GA ++ T L A GH EVA+ LL + A+VN A ++PL AA GH
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
Query: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543
+ LL+E AN G+TPL AAREGH E V LL + A+ T++ T L +A
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
Query: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603
G VA+ L++ A TPL A +L++VK LL G + H+ G
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
Query: 604 TPLHIAAKQNQVEVARSLLQYGGSANAES-----VQGVTP 638
T L A + +VA LLQ G + + ++G+ P
Sbjct: 570 TALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDP 609
Score = 178 bits (451), Expect = 5e-44
Identities = 135/379 (35%), Positives = 196/379 (51%), Gaps = 14/379 (3%)
Query: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA-KDDQTP 473
G + V+ LL G S N + E+ L +A AG+ E+A+ LL A V + K D TP
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
Query: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
L A+ G+ ++VKLLL ++A+ N + G+T L A G V+ V LL + A+
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 534 KKGFTPLHVAAKYGKVRVAELLLERDA----HPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
+ G TPL AA G V VA +LL+ A H N ++ LT +A + +LD+V+ LL
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
Query: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649
G +T L A VEVAR LL G N + +PL LAA GH E
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
Query: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVA 708
+ ALL+ + AN N G TPL A+EGH + +L+ G ++A T T L +A
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
Query: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYS-PLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767
G ++ FL++ AD+ +LG S PL +A+Q+GH ++V LL +GA+ + ++ G
Sbjct: 513 CCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATG 568
Query: 768 TTPLAIAKRLGYISVTDVL 786
T L A G+ V DVL
Sbjct: 569 DTALTYACENGHTDVADVL 587
Score = 177 bits (450), Expect = 7e-44
Identities = 140/427 (32%), Positives = 214/427 (50%), Gaps = 38/427 (8%)
Query: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
A +G V V +LL + + T++G + L +A AG E+ + L+ ANV + KG
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170
TPL A+ +L++VK LL + A+ N + G T L A G ++V L+N G
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 329
Query: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230
N + ++ G TPL AA ++ VA++LL+ GA
Sbjct: 330 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
Query: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
+N T N + L +A +G++ MVR LL+ GA E KT + T L A +GHV ++
Sbjct: 363 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 421
Query: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348
+LLD GA + + SP+ +AA G H++ LL++ A ++++ + TPL AA
Sbjct: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
Query: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407
GH + +LL +GA N++ T L +AC V + L+K GA I+ TP
Sbjct: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 538
Query: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
L AS GHL +VK LL GA+ + + +T L A GHT+VA LLQ A ++ K
Sbjct: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQ 597
Query: 468 KDDQTPL 474
+D +T L
Sbjct: 598 EDMKTIL 604
Score = 173 bits (438), Expect = 2e-42
Identities = 133/384 (34%), Positives = 193/384 (50%), Gaps = 6/384 (1%)
Query: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
AC V + LL G S++ TE G + L +A G+ + + LL A+ K
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 438 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
+ TPL A+ G+ ++ K LL + A VN+++ T L A G ++VK+LL AN
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
Query: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 555
GHTPL AA GHVE LL+ A + + + L +A G + + L
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391
Query: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615
LE A T L A ++++ +LLL G + PA + +PL +AA V
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451
Query: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 674
E+A L++ G + + +G TPL AA+EGH EMVALLL++ AN N + T L L
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511
Query: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734
G VAD LIK G ++ TPL AS G+++LVK+LL A+V+A T G
Sbjct: 512 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 568
Query: 735 YSPLHQAAQQGHTDIVTLLLKNGA 758
+ L A + GHTD+ +LL+ GA
Sbjct: 569 DTALTYACENGHTDVADVLLQAGA 592
Score = 167 bits (424), Expect = 7e-41
Identities = 131/386 (33%), Positives = 192/386 (49%), Gaps = 7/386 (1%)
Query: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG- 371
+ GD ++ VR LL +++ T + + L +A G++ +A+VLL A R G
Sbjct: 214 SDGD-VNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGD 272
Query: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
TPL A ++ +++LLL A +++ + +G T L A G + IVK LL GA+
Sbjct: 273 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 332
Query: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLL 490
N TPL AA AGH EVA+ LL + A +N + + ++ L A GH +MV+ LL
Sbjct: 333 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 392
Query: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550
E A+ T HT L A +GHVE LL+ A +PL +AA G V
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
Query: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY-TPLHIA 609
+A LL+ER A+ G TPL A + ++V LLL +G + ++ T L +A
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
Query: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
EVA L++ G TPL A+QEGH E+V LL+ AN + +G
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
Query: 670 TPLHLVAQEGHVPVADVLIKHGVMVD 695
T L + GH VADVL++ G +D
Sbjct: 570 TALTYACENGHTDVADVLLQAGADLD 595
Score = 162 bits (409), Expect = 4e-39
Identities = 123/383 (32%), Positives = 183/383 (47%), Gaps = 6/383 (1%)
Query: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI-DAVTESGLTP 407
G + LLD+G N G + L +AC + + ++LL A++ D + +TP
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
Query: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
L AS G+L IVK LL A N + T L A G ++ K LL A +
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKE 526
++ TPL AA GH + ++LL++ A N + + L +A +GH++ V LLE
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
Query: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586
A Q T + T L A G V VA LLL+ A N + +PL +A ++++
Sbjct: 396 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 455
Query: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQE 645
LL+ RG + GYTPL AA++ E+ LL G + NA++ + T L LA
Sbjct: 456 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 515
Query: 646 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 705
G +E+ L+ A+ LG TPL +QEGH+ + L+ G V ATT G T L
Sbjct: 516 GFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
Query: 706 HVASHYGNIKLVKFLLQHQADVN 728
A G+ + LLQ AD++
Sbjct: 573 TYACENGHTDVADVLLQAGADLD 595
Score = 150 bits (380), Expect = 9e-36
Identities = 112/359 (31%), Positives = 175/359 (48%), Gaps = 34/359 (9%)
Query: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
N+ + L AS G++ +V LL + + + + GNTAL A G ++V+ L+N G
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160
AN+ ++ G TPL AA H+EV + LL++GA N + E + L +A +GH ++V
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220
L+ G + + +H T L A ++
Sbjct: 389 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 419
Query: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
VA+LLL+ GA VN + +PL +A+ G+V + LL++RGA +E + TPL AA
Sbjct: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479
Query: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339
R GH + +LL GA I A+T+ + + +A G + L++ A DI L
Sbjct: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 536
Query: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
TPL A+ GH + K LL GA ++ G T L AC+ H V ++LL+ GA +D
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
Score = 138 bits (347), Expect = 6e-32
Identities = 106/327 (32%), Positives = 165/327 (50%), Gaps = 13/327 (3%)
Query: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
T + A+ G LD L + D+N+ + G L A G V +V LL++ +E
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
Query: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132
+ G+T L AA AG EV R L+++GA +N S + + L +A + HL++V+FLLE
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
Query: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------LHIAARNDDT 186
GA+Q T++ T L A GH V L++ G +V +PA L +AA
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPLTLAACGGHV 451
Query: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHI 245
AA+L++ N + ++ G+TPL AA + + LLL +GA++N T + T L +
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511
Query: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
A G + L+ GA IE TPL A++ GH+ + + LL GA + A T G
Sbjct: 512 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 568
Query: 306 LSPIHMAAQGDHLDCVRLLLQYDAEID 332
+ + A + H D +LLQ A++D
Sbjct: 569 DTALTYACENGHTDVADVLLQAGADLD 595
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 182 bits (461), Expect = 3e-45
Identities = 136/400 (34%), Positives = 201/400 (50%), Gaps = 17/400 (4%)
Query: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308
G+V VR LLD G + T++ + L A G+ ++++LL A ++ + G ++P
Sbjct: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
Query: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
+ A+ G +LD V+LLL +DA+++ + T L A G + KVLL++GA
Sbjct: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
Query: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424
NG TPL A HV V +LL GA I+ + ES LT +A + GHL +V+ LL
Sbjct: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 381
Query: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
+ GA ++ T L A GH EVA+ LL + A+VN A ++PL AA GH
Sbjct: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
Query: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543
+ LL+E AN G+TPL AAREGH E V LL + A+ T++ T L +A
Sbjct: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
Query: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603
G VA+ L++ A TPL A +L++VK LL G + H+ G
Sbjct: 502 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 558
Query: 604 TPLHIAAKQNQVEVARSLLQYGGSANAES-----VQGVTP 638
T L A + +VA LLQ G + + ++G+ P
Sbjct: 559 TALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDP 598
Score = 178 bits (451), Expect = 5e-44
Identities = 135/379 (35%), Positives = 196/379 (51%), Gaps = 14/379 (3%)
Query: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA-KDDQTP 473
G + V+ LL G S N + E+ L +A AG+ E+A+ LL A V + K D TP
Sbjct: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
Query: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
L A+ G+ ++VKLLL ++A+ N + G+T L A G V+ V LL + A+
Sbjct: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
Query: 534 KKGFTPLHVAAKYGKVRVAELLLERDA----HPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
+ G TPL AA G V VA +LL+ A H N ++ LT +A + +LD+V+ LL
Sbjct: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 381
Query: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649
G +T L A VEVAR LL G N + +PL LAA GH E
Sbjct: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
Query: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVA 708
+ ALL+ + AN N G TPL A+EGH + +L+ G ++A T T L +A
Sbjct: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
Query: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYS-PLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767
G ++ FL++ AD+ +LG S PL +A+Q+GH ++V LL +GA+ + ++ G
Sbjct: 502 CCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATG 557
Query: 768 TTPLAIAKRLGYISVTDVL 786
T L A G+ V DVL
Sbjct: 558 DTALTYACENGHTDVADVL 576
Score = 177 bits (450), Expect = 7e-44
Identities = 140/427 (32%), Positives = 214/427 (50%), Gaps = 38/427 (8%)
Query: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
A +G V V +LL + + T++G + L +A AG E+ + L+ ANV + KG
Sbjct: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
Query: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170
TPL A+ +L++VK LL + A+ N + G T L A G ++V L+N G
Sbjct: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 318
Query: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230
N + ++ G TPL AA ++ VA++LL+ GA
Sbjct: 319 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 351
Query: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
+N T N + L +A +G++ MVR LL+ GA E KT + T L A +GHV ++
Sbjct: 352 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 410
Query: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348
+LLD GA + + SP+ +AA G H++ LL++ A ++++ + TPL AA
Sbjct: 411 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 470
Query: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407
GH + +LL +GA N++ T L +AC V + L+K GA I+ TP
Sbjct: 471 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 527
Query: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
L AS GHL +VK LL GA+ + + +T L A GHT+VA LLQ A ++ K
Sbjct: 528 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQ 586
Query: 468 KDDQTPL 474
+D +T L
Sbjct: 587 EDMKTIL 593
Score = 173 bits (438), Expect = 2e-42
Identities = 133/384 (34%), Positives = 193/384 (50%), Gaps = 6/384 (1%)
Query: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
AC V + LL G S++ TE G + L +A G+ + + LL A+ K
Sbjct: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
Query: 438 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
+ TPL A+ G+ ++ K LL + A VN+++ T L A G ++VK+LL AN
Sbjct: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
Query: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 555
GHTPL AA GHVE LL+ A + + + L +A G + + L
Sbjct: 321 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 380
Query: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615
LE A T L A ++++ +LLL G + PA + +PL +AA V
Sbjct: 381 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 440
Query: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 674
E+A L++ G + + +G TPL AA+EGH EMVALLL++ AN N + T L L
Sbjct: 441 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 500
Query: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734
G VAD LIK G ++ TPL AS G+++LVK+LL A+V+A T G
Sbjct: 501 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 557
Query: 735 YSPLHQAAQQGHTDIVTLLLKNGA 758
+ L A + GHTD+ +LL+ GA
Sbjct: 558 DTALTYACENGHTDVADVLLQAGA 581
Score = 167 bits (424), Expect = 7e-41
Identities = 131/386 (33%), Positives = 192/386 (49%), Gaps = 7/386 (1%)
Query: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG- 371
+ GD ++ VR LL +++ T + + L +A G++ +A+VLL A R G
Sbjct: 203 SDGD-VNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGD 261
Query: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
TPL A ++ +++LLL A +++ + +G T L A G + IVK LL GA+
Sbjct: 262 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 321
Query: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLL 490
N TPL AA AGH EVA+ LL + A +N + + ++ L A GH +MV+ LL
Sbjct: 322 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 381
Query: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550
E A+ T HT L A +GHVE LL+ A +PL +AA G V
Sbjct: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
Query: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY-TPLHIA 609
+A LL+ER A+ G TPL A + ++V LLL +G + ++ T L +A
Sbjct: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
Query: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
EVA L++ G TPL A+QEGH E+V LL+ AN + +G
Sbjct: 502 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 558
Query: 670 TPLHLVAQEGHVPVADVLIKHGVMVD 695
T L + GH VADVL++ G +D
Sbjct: 559 TALTYACENGHTDVADVLLQAGADLD 584
Score = 162 bits (409), Expect = 4e-39
Identities = 123/383 (32%), Positives = 183/383 (47%), Gaps = 6/383 (1%)
Query: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI-DAVTESGLTP 407
G + LLD+G N G + L +AC + + ++LL A++ D + +TP
Sbjct: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
Query: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
L AS G+L IVK LL A N + T L A G ++ K LL A +
Sbjct: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
Query: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKE 526
++ TPL AA GH + ++LL++ A N + + L +A +GH++ V LLE
Sbjct: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 384
Query: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586
A Q T + T L A G V VA LLL+ A N + +PL +A ++++
Sbjct: 385 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 444
Query: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQE 645
LL+ RG + GYTPL AA++ E+ LL G + NA++ + T L LA
Sbjct: 445 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 504
Query: 646 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 705
G +E+ L+ A+ LG TPL +QEGH+ + L+ G V ATT G T L
Sbjct: 505 GFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 561
Query: 706 HVASHYGNIKLVKFLLQHQADVN 728
A G+ + LLQ AD++
Sbjct: 562 TYACENGHTDVADVLLQAGADLD 584
Score = 150 bits (380), Expect = 9e-36
Identities = 112/359 (31%), Positives = 175/359 (48%), Gaps = 34/359 (9%)
Query: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
N+ + L AS G++ +V LL + + + + GNTAL A G ++V+ L+N G
Sbjct: 258 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317
Query: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160
AN+ ++ G TPL AA H+EV + LL++GA N + E + L +A +GH ++V
Sbjct: 318 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 377
Query: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220
L+ G + + +H T L A ++
Sbjct: 378 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 408
Query: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
VA+LLL+ GA VN + +PL +A+ G+V + LL++RGA +E + TPL AA
Sbjct: 409 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 468
Query: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339
R GH + +LL GA I A+T+ + + +A G + L++ A DI L
Sbjct: 469 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 525
Query: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
TPL A+ GH + K LL GA ++ G T L AC+ H V ++LL+ GA +D
Sbjct: 526 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
Score = 138 bits (347), Expect = 6e-32
Identities = 106/327 (32%), Positives = 165/327 (50%), Gaps = 13/327 (3%)
Query: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
T + A+ G LD L + D+N+ + G L A G V +V LL++ +E
Sbjct: 263 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322
Query: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132
+ G+T L AA AG EV R L+++GA +N S + + L +A + HL++V+FLLE
Sbjct: 323 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 382
Query: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------LHIAARNDDT 186
GA+Q T++ T L A GH V L++ G +V +PA L +AA
Sbjct: 383 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPLTLAACGGHV 440
Query: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHI 245
AA+L++ N + ++ G+TPL AA + + LLL +GA++N T + T L +
Sbjct: 441 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 500
Query: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
A G + L+ GA IE TPL A++ GH+ + + LL GA + A T G
Sbjct: 501 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 557
Query: 306 LSPIHMAAQGDHLDCVRLLLQYDAEID 332
+ + A + H D +LLQ A++D
Sbjct: 558 DTALTYACENGHTDVADVLLQAGADLD 584
>gi|215598566 ankyrin 1 isoform 10 [Homo sapiens]
Length = 156
Score = 172 bits (436), Expect = 3e-42
Identities = 89/111 (80%), Positives = 97/111 (87%), Gaps = 7/111 (6%)
Query: 1778 RQQGQEEQVQEAKNTF-TQVVQ------GNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRK 1830
++ G+ E + + + T T+VV+ GNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRK
Sbjct: 46 KELGESEGLSDDEETISTRVVRRRVFLKGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRK 105
Query: 1831 VVRQIDLSSADAAQEHEEVTVEGPLEDPSELEVDIDYFMKHSKDHTSTPNP 1881
VVRQIDLSSADAAQEHEEVTVEGPLEDPSELEVDIDYFMKHSKDHTSTPNP
Sbjct: 106 VVRQIDLSSADAAQEHEEVTVEGPLEDPSELEVDIDYFMKHSKDHTSTPNP 156
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,048,268
Number of Sequences: 37866
Number of extensions: 3401167
Number of successful extensions: 23352
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 368
Number of HSP's successfully gapped in prelim test: 133
Number of HSP's that attempted gapping in prelim test: 7962
Number of HSP's gapped (non-prelim): 6056
length of query: 1881
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1764
effective length of database: 13,817,196
effective search space: 24373533744
effective search space used: 24373533744
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.