Search of human proteins with 70780353

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
         (1856 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                       3683   0.0  
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                       3669   0.0  
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                       3664   0.0  
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                      3658   0.0  
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                       3005   0.0  
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                       1758   0.0  
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                      1748   0.0  
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                       1743   0.0  
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                       1678   0.0  
gi|32967599 ankyrin 3 isoform 2 [Homo sapiens]                        775   0.0  
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   332   2e-90
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   327   9e-89
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   315   2e-85
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...   305   3e-82
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                  297   7e-80
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   296   1e-79
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   294   6e-79
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   235   3e-61
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...   228   5e-59
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...   223   1e-57
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                    223   1e-57
gi|34304381 inversin isoform a [Homo sapiens]                         199   2e-50
gi|34304379 inversin isoform b [Homo sapiens]                         199   2e-50
gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform...   197   6e-50
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi...   196   2e-49
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    191   4e-48
gi|116534990 ankyrin-like protein 1 [Homo sapiens]                    187   6e-47
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ...   182   3e-45
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ...   182   3e-45
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]    169   3e-41

>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score = 3683 bits (9550), Expect = 0.0
 Identities = 1856/1856 (100%), Positives = 1856/1856 (100%)

Query: 1    MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM 60
            MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM
Sbjct: 1    MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM 60

Query: 61   VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
            VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ
Sbjct: 61   VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120

Query: 121  ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA 180
            ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA
Sbjct: 121  ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA 180

Query: 181  ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 240
            ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI
Sbjct: 181  ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 240

Query: 241  TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
            TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA
Sbjct: 241  TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300

Query: 301  KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
            KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK
Sbjct: 301  KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360

Query: 361  GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
            GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV
Sbjct: 361  GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420

Query: 421  KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
            KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI
Sbjct: 421  KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480

Query: 481  GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
            GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL
Sbjct: 481  GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540

Query: 541  HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600
            HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW
Sbjct: 541  HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600

Query: 601  NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
            NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN
Sbjct: 601  NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660

Query: 661  GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
            GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL
Sbjct: 661  GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720

Query: 721  LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780
            LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI
Sbjct: 721  LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780

Query: 781  SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE 840
            SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE
Sbjct: 781  SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE 840

Query: 841  KELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSD 900
            KELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSD
Sbjct: 841  KELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSD 900

Query: 901  NISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLS 960
            NISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLS
Sbjct: 901  NISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLS 960

Query: 961  TPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEH 1020
            TPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEH
Sbjct: 961  TPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEH 1020

Query: 1021 RSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEG 1080
            RSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEG
Sbjct: 1021 RSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEG 1080

Query: 1081 GSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRK 1140
            GSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRK
Sbjct: 1081 GSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRK 1140

Query: 1141 FHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANEC 1200
            FHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANEC
Sbjct: 1141 FHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANEC 1200

Query: 1201 ANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYC 1260
            ANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYC
Sbjct: 1201 ANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYC 1260

Query: 1261 MTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRE 1320
            MTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRE
Sbjct: 1261 MTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRE 1320

Query: 1321 NRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPT 1380
            NRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPT
Sbjct: 1321 NRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPT 1380

Query: 1381 PLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENP 1440
            PLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENP
Sbjct: 1381 PLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENP 1440

Query: 1441 NSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHT 1500
            NSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHT
Sbjct: 1441 NSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHT 1500

Query: 1501 DRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTM 1560
            DRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTM
Sbjct: 1501 DRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTM 1560

Query: 1561 LEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLEL 1620
            LEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLEL
Sbjct: 1561 LEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLEL 1620

Query: 1621 VEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQ 1680
            VEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQ
Sbjct: 1621 VEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQ 1680

Query: 1681 ARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTE 1740
            ARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTE
Sbjct: 1681 ARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTE 1740

Query: 1741 GLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGN 1800
            GLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGN
Sbjct: 1741 GLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGN 1800

Query: 1801 EFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEDHTSTPNP 1856
            EFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEDHTSTPNP
Sbjct: 1801 EFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEDHTSTPNP 1856


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score = 3669 bits (9514), Expect = 0.0
 Identities = 1856/1881 (98%), Positives = 1856/1881 (98%), Gaps = 25/1881 (1%)

Query: 1    MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM 60
            MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM
Sbjct: 1    MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM 60

Query: 61   VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
            VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ
Sbjct: 61   VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120

Query: 121  ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA 180
            ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA
Sbjct: 121  ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA 180

Query: 181  ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 240
            ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI
Sbjct: 181  ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 240

Query: 241  TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
            TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA
Sbjct: 241  TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300

Query: 301  KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
            KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK
Sbjct: 301  KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360

Query: 361  GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
            GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV
Sbjct: 361  GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420

Query: 421  KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
            KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI
Sbjct: 421  KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480

Query: 481  GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
            GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL
Sbjct: 481  GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540

Query: 541  HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600
            HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW
Sbjct: 541  HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600

Query: 601  NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
            NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN
Sbjct: 601  NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660

Query: 661  GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
            GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL
Sbjct: 661  GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720

Query: 721  LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780
            LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI
Sbjct: 721  LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780

Query: 781  SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE 840
            SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE
Sbjct: 781  SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE 840

Query: 841  KELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSD 900
            KELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSD
Sbjct: 841  KELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSD 900

Query: 901  NISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLS 960
            NISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLS
Sbjct: 901  NISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLS 960

Query: 961  TPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEH 1020
            TPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEH
Sbjct: 961  TPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEH 1020

Query: 1021 RSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEG 1080
            RSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEG
Sbjct: 1021 RSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEG 1080

Query: 1081 GSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRK 1140
            GSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRK
Sbjct: 1081 GSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRK 1140

Query: 1141 FHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANEC 1200
            FHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANEC
Sbjct: 1141 FHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANEC 1200

Query: 1201 ANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYC 1260
            ANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYC
Sbjct: 1201 ANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYC 1260

Query: 1261 MTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRE 1320
            MTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRE
Sbjct: 1261 MTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRE 1320

Query: 1321 NRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPT 1380
            NRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPT
Sbjct: 1321 NRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPT 1380

Query: 1381 PLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENP 1440
            PLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENP
Sbjct: 1381 PLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENP 1440

Query: 1441 NSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHT 1500
            NSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHT
Sbjct: 1441 NSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHT 1500

Query: 1501 DRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTM 1560
            DRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTM
Sbjct: 1501 DRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTM 1560

Query: 1561 LEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLEL 1620
            LEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLEL
Sbjct: 1561 LEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLEL 1620

Query: 1621 VEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQ 1680
            VEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQ
Sbjct: 1621 VEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQ 1680

Query: 1681 ARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTE 1740
            ARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTE
Sbjct: 1681 ARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTE 1740

Query: 1741 GLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGN 1800
            GLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGN
Sbjct: 1741 GLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGN 1800

Query: 1801 EFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEE------------ 1848
            EFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEE            
Sbjct: 1801 EFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPSE 1860

Query: 1849 -------------DHTSTPNP 1856
                         DHTSTPNP
Sbjct: 1861 LEVDIDYFMKHSKDHTSTPNP 1881


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score = 3664 bits (9502), Expect = 0.0
 Identities = 1848/1848 (100%), Positives = 1848/1848 (100%)

Query: 1    MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM 60
            MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM
Sbjct: 1    MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM 60

Query: 61   VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
            VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ
Sbjct: 61   VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120

Query: 121  ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA 180
            ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA
Sbjct: 121  ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA 180

Query: 181  ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 240
            ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI
Sbjct: 181  ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 240

Query: 241  TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
            TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA
Sbjct: 241  TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300

Query: 301  KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
            KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK
Sbjct: 301  KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360

Query: 361  GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
            GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV
Sbjct: 361  GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420

Query: 421  KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
            KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI
Sbjct: 421  KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480

Query: 481  GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
            GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL
Sbjct: 481  GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540

Query: 541  HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600
            HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW
Sbjct: 541  HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600

Query: 601  NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
            NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN
Sbjct: 601  NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660

Query: 661  GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
            GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL
Sbjct: 661  GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720

Query: 721  LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780
            LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI
Sbjct: 721  LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780

Query: 781  SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE 840
            SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE
Sbjct: 781  SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE 840

Query: 841  KELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSD 900
            KELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSD
Sbjct: 841  KELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSD 900

Query: 901  NISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLS 960
            NISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLS
Sbjct: 901  NISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLS 960

Query: 961  TPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEH 1020
            TPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEH
Sbjct: 961  TPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEH 1020

Query: 1021 RSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEG 1080
            RSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEG
Sbjct: 1021 RSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEG 1080

Query: 1081 GSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRK 1140
            GSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRK
Sbjct: 1081 GSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRK 1140

Query: 1141 FHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANEC 1200
            FHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANEC
Sbjct: 1141 FHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANEC 1200

Query: 1201 ANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYC 1260
            ANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYC
Sbjct: 1201 ANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYC 1260

Query: 1261 MTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRE 1320
            MTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRE
Sbjct: 1261 MTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRE 1320

Query: 1321 NRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPT 1380
            NRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPT
Sbjct: 1321 NRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPT 1380

Query: 1381 PLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENP 1440
            PLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENP
Sbjct: 1381 PLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENP 1440

Query: 1441 NSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHT 1500
            NSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHT
Sbjct: 1441 NSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHT 1500

Query: 1501 DRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTM 1560
            DRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTM
Sbjct: 1501 DRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTM 1560

Query: 1561 LEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLEL 1620
            LEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLEL
Sbjct: 1561 LEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLEL 1620

Query: 1621 VEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQ 1680
            VEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQ
Sbjct: 1621 VEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQ 1680

Query: 1681 ARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTE 1740
            ARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTE
Sbjct: 1681 ARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTE 1740

Query: 1741 GLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGN 1800
            GLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGN
Sbjct: 1741 GLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGN 1800

Query: 1801 EFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEE 1848
            EFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEE
Sbjct: 1801 EFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEE 1848


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score = 3658 bits (9485), Expect = 0.0
 Identities = 1847/1857 (99%), Positives = 1849/1857 (99%), Gaps = 8/1857 (0%)

Query: 8    READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
            ++ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK
Sbjct: 41   KKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 100

Query: 68   EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
            EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV
Sbjct: 101  EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 160

Query: 128  KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187
            KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR
Sbjct: 161  KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 220

Query: 188  TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 247
            TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS
Sbjct: 221  TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 280

Query: 248  RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307
            RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS
Sbjct: 281  RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 340

Query: 308  PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367
            PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR
Sbjct: 341  PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 400

Query: 368  ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427
            ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG
Sbjct: 401  ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 460

Query: 428  ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487
            ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK
Sbjct: 461  ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 520

Query: 488  LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 547
            LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG
Sbjct: 521  LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 580

Query: 548  KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 607
            KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH
Sbjct: 581  KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 640

Query: 608  IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS 667
            IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS
Sbjct: 641  IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS 700

Query: 668  GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727
            GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV
Sbjct: 701  GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 760

Query: 728  NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
            NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK
Sbjct: 761  NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 820

Query: 788  VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEG--------EELISFKAERRDSRDVDE 839
            VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEG        EELISFKAERRDSRDVDE
Sbjct: 821  VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGTAHITIMGEELISFKAERRDSRDVDE 880

Query: 840  EKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETS 899
            EKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETS
Sbjct: 881  EKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETS 940

Query: 900  DNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKL 959
            DNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKL
Sbjct: 941  DNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKL 1000

Query: 960  STPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKE 1019
            STPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKE
Sbjct: 1001 STPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKE 1060

Query: 1020 HRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPE 1079
            HRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPE
Sbjct: 1061 HRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPE 1120

Query: 1080 GGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRR 1139
            GGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRR
Sbjct: 1121 GGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRR 1180

Query: 1140 KFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANE 1199
            KFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANE
Sbjct: 1181 KFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANE 1240

Query: 1200 CANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCY 1259
            CANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCY
Sbjct: 1241 CANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCY 1300

Query: 1260 CMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFR 1319
            CMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFR
Sbjct: 1301 CMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFR 1360

Query: 1320 ENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTP 1379
            ENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTP
Sbjct: 1361 ENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTP 1420

Query: 1380 TPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVEN 1439
            TPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVEN
Sbjct: 1421 TPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVEN 1480

Query: 1440 PNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRH 1499
            PNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRH
Sbjct: 1481 PNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRH 1540

Query: 1500 TDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDT 1559
            TDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDT
Sbjct: 1541 TDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDT 1600

Query: 1560 MLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLE 1619
            MLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLE
Sbjct: 1601 MLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLE 1660

Query: 1620 LVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRG 1679
            LVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRG
Sbjct: 1661 LVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRG 1720

Query: 1680 QARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMT 1739
            QARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMT
Sbjct: 1721 QARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMT 1780

Query: 1740 EGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQG 1799
            EGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQG
Sbjct: 1781 EGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQG 1840

Query: 1800 NEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEDHTSTPNP 1856
            NEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEDHTSTPNP
Sbjct: 1841 NEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEDHTSTPNP 1897



 Score =  337 bits (865), Expect = 5e-92
 Identities = 211/572 (36%), Positives = 309/572 (54%), Gaps = 41/572 (7%)

Query: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
           SV F   +  T    A+R GN+      L  G  I T  ++ L  LH A++ GHV++   
Sbjct: 264 SVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEI 323

Query: 64  LLHKEIILETTTKKG---------------------------------NTALHIAALAGQ 90
           LL     ++  TK G                                  T LH+AA  G 
Sbjct: 324 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGH 383

Query: 91  DEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAV 150
             V + L++ GA  N+++  GFTPL++A ++NH+ V++ LL+ GA+ +  TE G TPL V
Sbjct: 384 HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV 443

Query: 151 ALQQGHENVVAHLINYG-----TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT 205
           A   GH  +V +L+  G     +  KV  P LH+AAR   T  A  LLQN    +  +K 
Sbjct: 444 ASFMGHLPIVKNLLQRGASPNVSNVKVETP-LHMAARAGHTEVAKYLLQNKAKVNAKAKD 502

Query: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
             TPLH AA   + N+ +LLL   A+ N     G TPLHIA+R G+V  V  LL++ A  
Sbjct: 503 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 562

Query: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLL 325
              TK   TPLH AA+ G VR++E+LL+  A   A  KNGL+P+H+A   ++LD V+LLL
Sbjct: 563 ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 622

Query: 326 QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR 385
                      +  TPLH+AA      VA+ LL  G   N+ ++ G TPLH+A ++ H  
Sbjct: 623 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 682

Query: 386 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 445
           ++ LLL   A+ +   +SGLTPLH+ +  GH+P+   L++ G   + +     TPLH+A+
Sbjct: 683 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 742

Query: 446 RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505
             G+ ++ K+LLQ++A VNAK K   +PLH AA+ GHT++V LLL+N A+PN  ++ G T
Sbjct: 743 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 802

Query: 506 PLHIAAREGHVET--VLALLEKEASQACMTKK 535
           PL IA R G++    VL ++  E S   ++ K
Sbjct: 803 PLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 834



 Score =  205 bits (522), Expect = 3e-52
 Identities = 123/358 (34%), Positives = 187/358 (52%), Gaps = 29/358 (8%)

Query: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517
           +N+++   K  D  T    AAR G+ +     L N  + N     G   LH+A++EGHV+
Sbjct: 33  RNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVK 92

Query: 518 TVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 577
            V+ LL KE      TKKG T LH+AA  G+  V   L+   A+ NA  + G TPL++A 
Sbjct: 93  MVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 152

Query: 578 HHNNLDIVKLLLPRGGSPHSPAWNGYTP-----------------------------LHI 608
             N+L++VK LL  G + +    +G+TP                             LHI
Sbjct: 153 QENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHI 212

Query: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
           AA+ +    A  LLQ   + +  S  G TPLH+AA   +  +  LLL++ A+ N   ++G
Sbjct: 213 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 272

Query: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
           +TPLH+ ++ G+V +  +L+  G  ++  T+   TPLH A+  G++++ + LL H A + 
Sbjct: 273 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 332

Query: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
           AKTK G SP+H AAQ  H D V LLL+  A  ++++ D  TPL +A   G+  V  VL
Sbjct: 333 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 390


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score = 3005 bits (7790), Expect = 0.0
 Identities = 1513/1514 (99%), Positives = 1514/1514 (100%)

Query: 1    MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM 60
            MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM
Sbjct: 1    MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM 60

Query: 61   VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
            VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ
Sbjct: 61   VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120

Query: 121  ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA 180
            ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA
Sbjct: 121  ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA 180

Query: 181  ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 240
            ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI
Sbjct: 181  ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 240

Query: 241  TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
            TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA
Sbjct: 241  TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300

Query: 301  KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
            KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK
Sbjct: 301  KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360

Query: 361  GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
            GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV
Sbjct: 361  GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420

Query: 421  KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
            KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI
Sbjct: 421  KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480

Query: 481  GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
            GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL
Sbjct: 481  GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540

Query: 541  HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600
            HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW
Sbjct: 541  HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600

Query: 601  NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
            NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN
Sbjct: 601  NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660

Query: 661  GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
            GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL
Sbjct: 661  GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720

Query: 721  LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780
            LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI
Sbjct: 721  LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780

Query: 781  SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE 840
            SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE
Sbjct: 781  SVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEE 840

Query: 841  KELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSD 900
            KELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSD
Sbjct: 841  KELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSD 900

Query: 901  NISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLS 960
            NISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLS
Sbjct: 901  NISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLS 960

Query: 961  TPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEH 1020
            TPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEH
Sbjct: 961  TPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEH 1020

Query: 1021 RSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEG 1080
            RSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEG
Sbjct: 1021 RSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEG 1080

Query: 1081 GSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRK 1140
            GSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRK
Sbjct: 1081 GSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRK 1140

Query: 1141 FHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANEC 1200
            FHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANEC
Sbjct: 1141 FHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANEC 1200

Query: 1201 ANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYC 1260
            ANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYC
Sbjct: 1201 ANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYC 1260

Query: 1261 MTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRE 1320
            MTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRE
Sbjct: 1261 MTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRE 1320

Query: 1321 NRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPT 1380
            NRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPT
Sbjct: 1321 NRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPT 1380

Query: 1381 PLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENP 1440
            PLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENP
Sbjct: 1381 PLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENP 1440

Query: 1441 NSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHT 1500
            NSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHT
Sbjct: 1441 NSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHT 1500

Query: 1501 DRDYSLSPSQMNGY 1514
            DRDYSLSPSQMNG+
Sbjct: 1501 DRDYSLSPSQMNGH 1514



 Score =  358 bits (919), Expect = 3e-98
 Identities = 190/237 (80%), Positives = 193/237 (81%), Gaps = 30/237 (12%)

Query: 1650 LPGSKRQD-----DATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDRLQDWD 1704
            L GS RQ      D     +D     S ++GHQRGQARITHSPTVSQVTERSQDRLQDWD
Sbjct: 1483 LEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGHQRGQARITHSPTVSQVTERSQDRLQDWD 1542

Query: 1705 ADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTE 1764
            ADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTE
Sbjct: 1543 ADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTE 1602

Query: 1765 QPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVT 1824
            QPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVT
Sbjct: 1603 QPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVT 1662

Query: 1825 KKIIRKVVRQIDLSSADAAQEHEE-------------------------DHTSTPNP 1856
            KKIIRKVVRQIDLSSADAAQEHEE                         DHTSTPNP
Sbjct: 1663 KKIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPSELEVDIDYFMKHSKDHTSTPNP 1719


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score = 1758 bits (4552), Expect = 0.0
 Identities = 908/1585 (57%), Positives = 1158/1585 (73%), Gaps = 81/1585 (5%)

Query: 8    READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
            +++D+  SFLRAAR+GNLDK +++L+ G+DINTCNQNGLN LHLA+KEGHV +V ELL +
Sbjct: 27   KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86

Query: 68   EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
               +++ TKKGNTALHIA+LAGQ EVV+ LV  GAN+NAQSQ GFTPLYMAAQENH++VV
Sbjct: 87   GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146

Query: 128  KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187
            K+LLENGANQ+ ATEDGFTPLAVALQQGH   VA L+   TKGKVRLPALHIAAR DDT+
Sbjct: 147  KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 206

Query: 188  TAAVLLQNDPNPDVLSK--------TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
            +AA+LLQND N DV SK        +GFTPLHIAAHY N+NVA LLLNRGA+V+FT +NG
Sbjct: 207  SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 266

Query: 240  ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
            ITPLH+AS+RGN  MV+LLLDRG QI+ KT+D LTPLHCAAR+GH ++ E+LL+ GAP+ 
Sbjct: 267  ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 326

Query: 300  AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
            A+TKNGLSP+HMAAQGDH++CV+ LLQ+ A +DD+TLD+LT LHVAAHCGH+RV K+LLD
Sbjct: 327  ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 386

Query: 360  KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
            K A PN+RALNGFTPLHIACKKN ++VMELL+K GASI A+TESGLTP+HVA+FMGHL I
Sbjct: 387  KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 446

Query: 420  VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
            V  LLQ GASP+V+N++ ET LHMAARAG  EV + LL+N A V+A+A+++QTPLH A+R
Sbjct: 447  VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 506

Query: 480  IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
            +G T +V+LLL++ A+P+ ATT G+TPLHI+AREG V+    LLE  A+ +  TKKGFTP
Sbjct: 507  LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 566

Query: 540  LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
            LHVAAKYG + VA+LLL+R A  ++AGKNGLTPLHVA H++N  +  LLL +G SPH+ A
Sbjct: 567  LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626

Query: 600  WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
             NGYTPLHIAAK+NQ+++A +LL YG   N  + QGVTPLHLA+QEGH +MV LLL K A
Sbjct: 627  KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 686

Query: 660  NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719
            N ++  KSGLT LHL AQE  V VAD+L KHG   DA T++GYTPL VA HYGN+K+V F
Sbjct: 687  NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 746

Query: 720  LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779
            LL+  A+VNAKTK GY+PLHQAAQQGHT I+ +LL++GA PN  +++G T LAIAKRLGY
Sbjct: 747  LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 806

Query: 780  ISVTDVLKVVTDE--TSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAER------ 831
            ISV D LKVVT+E  T+   +++KH+++ PET+ E+LDVS++EG++ ++           
Sbjct: 807  ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPED 866

Query: 832  ---------------------RDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETV 870
                                 R S +      L  F       +   +  R    M ++V
Sbjct: 867  LKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSV 926

Query: 871  VIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSR 930
            VI S +    +KE + +S    S  TE  DN++  +SP+H+GFLVSFMVDARGG+MRG R
Sbjct: 927  VIPSHQVSTLAKEAERNS-YRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCR 985

Query: 931  HNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQ------ 984
            HNGLR++IPPR C APTR+TCRLVK  +L+T PP+ E EGLASR+I +GP+GAQ      
Sbjct: 986  HNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGKLH 1045

Query: 985  ---------------------------FLSPVIVEIPHFASHGRGDRELVVLRSENGSVW 1017
                                       FL PVIVEIPHFA+    +RELVVLRSENG  W
Sbjct: 1046 LPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVVLRSENGDSW 1105

Query: 1018 KEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIG 1077
            KEH   Y E  L++ILNGMDE L S E+LEKKR+CRIIT DFP YF ++SR+ QD + IG
Sbjct: 1106 KEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIG 1165

Query: 1078 PEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPR 1137
            PEGG L S +VP VQA FPE A+TKR+++ LQAQP+  ELV K+LGN+ATFSPIVT+EPR
Sbjct: 1166 PEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPR 1225

Query: 1138 RRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYA 1197
            RRKFH+PI + IP+P + +D   +   GD  +LRLLCS+ GGT  AQWEDITGTT L + 
Sbjct: 1226 RRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFV 1285

Query: 1198 NECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLR 1257
            NEC +FTTNVSARFWL DC +  E+V FA+ +Y+E+  VPYMAKFV+FAK +DP E RLR
Sbjct: 1286 NECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLR 1345

Query: 1258 CYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQS 1317
            C+CMTDDKVDKTLEQ ENF EVARSRD+EVLEG  ++ +  GNLVP+ K+ Q   F F +
Sbjct: 1346 CFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFA 1405

Query: 1318 FRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQH-ILCHLNITMPPCAKGSGAEDRR 1376
            F+ENRL + VKVRD+++EP G LSF+++        H  +C+LNIT+P   K S ++  +
Sbjct: 1406 FKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQ 1465

Query: 1377 RTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIR 1436
                       + SE  P      E+ E ++A I++HLG SW ELAREL F+ E I++IR
Sbjct: 1466 EE------EIDMTSEKNP--QDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIR 1517

Query: 1437 VENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPD 1496
            +ENPNSL +QS ALL  W+ R+G++A   NL   L  I+R +IV+++E +  +    +  
Sbjct: 1518 IENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLME-TNTEPLQERIS 1576

Query: 1497 RRHTDRDYSLSPSQMNGYSSLQDEL 1521
              + + + +++     G+S LQ+EL
Sbjct: 1577 HSYAEIEQTITLDHSEGFSVLQEEL 1601



 Score =  404 bits (1038), Expect = e-112
 Identities = 245/692 (35%), Positives = 368/692 (53%), Gaps = 41/692 (5%)

Query: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
           ++  +  +  T    AA+  ++D     L NG + +T  ++G   L +A ++GH + V  
Sbjct: 122 NINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAI 181

Query: 64  LLHKE-------------------------------------IILETTTKKGNTALHIAA 86
           LL  +                                     +++  TT+ G T LHIAA
Sbjct: 182 LLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAA 241

Query: 87  LAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFT 146
             G   V   L+N GA V+  ++ G TPL++A++  +  +VK LL+ G   +  T DG T
Sbjct: 242 HYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLT 301

Query: 147 PLAVALQQGHENVVAHLINYG----TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL 202
           PL  A + GH+ VV  L+  G     + K  L  LH+AA+ D       LLQ+    D +
Sbjct: 302 PLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDV 361

Query: 203 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 262
           +    T LH+AAH  +  V +LLL++ A+ N    NG TPLHIA ++  + ++ LL+  G
Sbjct: 362 TLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYG 421

Query: 263 AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR 322
           A I+  T+  LTP+H AA  GH+ I  +LL +GA        G + +HMAA+   ++ VR
Sbjct: 422 ASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVR 481

Query: 323 LLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382
            LL+  A +D    +  TPLH+A+  G   + ++LL   A P++   NG+TPLHI+ ++ 
Sbjct: 482 CLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541

Query: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLH 442
            V V  +LL+ GA+    T+ G TPLHVA+  G L + K LLQR A+ + +     TPLH
Sbjct: 542 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 601

Query: 443 MAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA 502
           +AA   + +VA  LL+  A  +A AK+  TPLH AA+     +   LL   A  N+ T  
Sbjct: 602 VAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ 661

Query: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562
           G TPLH+A++EGH + V  LL+K A+    TK G T LH+AA+  KV VA++L +  A  
Sbjct: 662 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ 721

Query: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
           +A  K G TPL VA H+ N+ +V  LL +G + ++   NGYTPLH AA+Q    +   LL
Sbjct: 722 DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL 781

Query: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
           Q+G   NA +  G T L +A + G+  +V  L
Sbjct: 782 QHGAKPNATTANGNTALAIAKRLGYISVVDTL 813



 Score =  201 bits (512), Expect = 4e-51
 Identities = 120/329 (36%), Positives = 178/329 (54%), Gaps = 12/329 (3%)

Query: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAARE 513
           K+   ++ +   K  D       AAR G+ + V   L+   + N     G   LH+AA+E
Sbjct: 15  KFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKE 74

Query: 514 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 573
           GHV  V  LL + +S    TKKG T LH+A+  G+  V ++L++  A+ NA  +NG TPL
Sbjct: 75  GHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 134

Query: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 633
           ++A   N++D+VK LL  G +  +   +G+TPL +A +Q   +    LL+          
Sbjct: 135 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR-- 192

Query: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK--------SGLTPLHLVAQEGHVPVAD 685
             +  LH+AA++   +  ALLL    N ++ +K        SG TPLH+ A  G+V VA 
Sbjct: 193 --LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250

Query: 686 VLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQG 745
           +L+  G  VD T R G TPLHVAS  GN  +VK LL     ++AKT+ G +PLH AA+ G
Sbjct: 251 LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSG 310

Query: 746 HTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
           H  +V LLL+ GA     + +G +PL +A
Sbjct: 311 HDQVVELLLERGAPLLARTKNGLSPLHMA 339



 Score =  181 bits (459), Expect = 6e-45
 Identities = 111/335 (33%), Positives = 173/335 (51%), Gaps = 4/335 (1%)

Query: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
           V  R  +  T    A+R G  +     L++    +    NG   LH++++EG V +   L
Sbjct: 490 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549

Query: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
           L         TKKG T LH+AA  G  +V + L+   A  ++  + G TPL++AA  ++ 
Sbjct: 550 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQ 609

Query: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIA 180
           +V   LLE GA+ +   ++G+TPL +A ++    + + L+NYG +     K  +  LH+A
Sbjct: 610 KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 669

Query: 181 ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 240
           ++   T    +LL    N  + +K+G T LH+AA  + +NVA +L   GA  +   + G 
Sbjct: 670 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 729

Query: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
           TPL +A   GNV MV  LL +GA +  KTK+  TPLH AA+ GH  I  +LL HGA   A
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789

Query: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335
            T NG + + +A +  ++  V  L     E+   T
Sbjct: 790 TTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTT 824



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 19/48 (39%), Positives = 30/48 (62%)

Query: 1798 QGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQE 1845
            +G++   IP E VTEE++ DE G+ V KK+ RK++R+   S     +E
Sbjct: 1785 KGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEE 1832


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score = 1748 bits (4528), Expect = 0.0
 Identities = 908/1597 (56%), Positives = 1158/1597 (72%), Gaps = 93/1597 (5%)

Query: 8    READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
            +++D+  SFLRAAR+GNLDK +++L+ G+DINTCNQNGLN LHLA+KEGHV +V ELL +
Sbjct: 6    QKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 65

Query: 68   EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
               +++ TKKGNTALHIA+LAGQ EVV+ LV  GAN+NAQSQ GFTPLYMAAQENH++VV
Sbjct: 66   GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125

Query: 128  KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187
            K+LLENGANQ+ ATEDGFTPLAVALQQGH   VA L+   TKGKVRLPALHIAAR DDT+
Sbjct: 126  KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 185

Query: 188  TAAVLLQNDPNPDVLSK--------TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
            +AA+LLQND N DV SK        +GFTPLHIAAHY N+NVA LLLNRGA+V+FT +NG
Sbjct: 186  SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 245

Query: 240  ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
            ITPLH+AS+RGN  MV+LLLDRG QI+ KT+D LTPLHCAAR+GH ++ E+LL+ GAP+ 
Sbjct: 246  ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 305

Query: 300  AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
            A+TKNGLSP+HMAAQGDH++CV+ LLQ+ A +DD+TLD+LT LHVAAHCGH+RV K+LLD
Sbjct: 306  ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 365

Query: 360  KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
            K A PN+RALNGFTPLHIACKKN ++VMELL+K GASI A+TESGLTP+HVA+FMGHL I
Sbjct: 366  KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 425

Query: 420  VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
            V  LLQ GASP+V+N++ ET LHMAARAG  EV + LL+N A V+A+A+++QTPLH A+R
Sbjct: 426  VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 485

Query: 480  IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
            +G T +V+LLL++ A+P+ ATT G+TPLHI+AREG V+    LLE  A+ +  TKKGFTP
Sbjct: 486  LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 545

Query: 540  LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
            LHVAAKYG + VA+LLL+R A  ++AGKNGLTPLHVA H++N  +  LLL +G SPH+ A
Sbjct: 546  LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605

Query: 600  WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
             NGYTPLHIAAK+NQ+++A +LL YG   N  + QGVTPLHLA+QEGH +MV LLL K A
Sbjct: 606  KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 665

Query: 660  NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719
            N ++  KSGLT LHL AQE  V VAD+L KHG   DA T++GYTPL VA HYGN+K+V F
Sbjct: 666  NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 725

Query: 720  LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779
            LL+  A+VNAKTK GY+PLHQAAQQGHT I+ +LL++GA PN  +++G T LAIAKRLGY
Sbjct: 726  LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 785

Query: 780  ISVTDVLKVVTDE--TSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAER------ 831
            ISV D LKVVT+E  T+   +++KH+++ PET+ E+LDVS++EG++ ++           
Sbjct: 786  ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPED 845

Query: 832  ---------------------RDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETV 870
                                 R S +      L  F       +   +  R    M ++V
Sbjct: 846  LKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSV 905

Query: 871  VIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTG------------FLVSFM 918
            VI S +    +KE + +S    S  TE  DN++  +SP+H+G            FLVSFM
Sbjct: 906  VIPSHQVSTLAKEAERNS-YRLSWGTENLDNVALSSSPIHSGRASPCLERDNSSFLVSFM 964

Query: 919  VDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIAL 978
            VDARGG+MRG RHNGLR++IPPR C APTR+TCRLVK  +L+T PP+ E EGLASR+I +
Sbjct: 965  VDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEV 1024

Query: 979  GPTGAQ---------------------------------FLSPVIVEIPHFASHGRGDRE 1005
            GP+GAQ                                 FL PVIVEIPHFA+    +RE
Sbjct: 1025 GPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERE 1084

Query: 1006 LVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVI 1065
            LVVLRSENG  WKEH   Y E  L++ILNGMDE L S E+LEKKR+CRIIT DFP YF +
Sbjct: 1085 LVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAV 1144

Query: 1066 MSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQ 1125
            +SR+ QD + IGPEGG L S +VP VQA FPE A+TKR+++ LQAQP+  ELV K+LGN+
Sbjct: 1145 VSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNK 1204

Query: 1126 ATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQW 1185
            ATFSPIVT+EPRRRKFH+PI + IP+P + +D   +   GD  +LRLLCS+ GGT  AQW
Sbjct: 1205 ATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQW 1264

Query: 1186 EDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIF 1245
            EDITGTT L + NEC +FTTNVSARFWL DC +  E+V FA+ +Y+E+  VPYMAKFV+F
Sbjct: 1265 EDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVF 1324

Query: 1246 AKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVK 1305
            AK +DP E RLRC+CMTDDKVDKTLEQ ENF EVARSRD+EVLEG  ++ +  GNLVP+ 
Sbjct: 1325 AKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLT 1384

Query: 1306 KAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQH-ILCHLNITMP 1364
            K+ Q   F F +F+ENRL + VKVRD+++EP G LSF+++        H  +C+LNIT+P
Sbjct: 1385 KSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLP 1444

Query: 1365 PCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARE 1424
               K S ++  +           + SE  P      E+ E ++A I++HLG SW ELARE
Sbjct: 1445 IYTKESESDQEQEE------EIDMTSEKNP--QDEQERIEERLAYIADHLGFSWTELARE 1496

Query: 1425 LQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLE 1484
            L F+ E I++IR+ENPNSL +QS ALL  W+ R+G++A   NL   L  I+R +IV+++E
Sbjct: 1497 LDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLME 1556

Query: 1485 GSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDEL 1521
             +  +    +    + + + +++     G+S LQ+EL
Sbjct: 1557 -TNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEEL 1592



 Score =  404 bits (1038), Expect = e-112
 Identities = 245/692 (35%), Positives = 368/692 (53%), Gaps = 41/692 (5%)

Query: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
           ++  +  +  T    AA+  ++D     L NG + +T  ++G   L +A ++GH + V  
Sbjct: 101 NINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAI 160

Query: 64  LLHKE-------------------------------------IILETTTKKGNTALHIAA 86
           LL  +                                     +++  TT+ G T LHIAA
Sbjct: 161 LLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAA 220

Query: 87  LAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFT 146
             G   V   L+N GA V+  ++ G TPL++A++  +  +VK LL+ G   +  T DG T
Sbjct: 221 HYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLT 280

Query: 147 PLAVALQQGHENVVAHLINYG----TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL 202
           PL  A + GH+ VV  L+  G     + K  L  LH+AA+ D       LLQ+    D +
Sbjct: 281 PLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDV 340

Query: 203 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 262
           +    T LH+AAH  +  V +LLL++ A+ N    NG TPLHIA ++  + ++ LL+  G
Sbjct: 341 TLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYG 400

Query: 263 AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR 322
           A I+  T+  LTP+H AA  GH+ I  +LL +GA        G + +HMAA+   ++ VR
Sbjct: 401 ASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVR 460

Query: 323 LLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382
            LL+  A +D    +  TPLH+A+  G   + ++LL   A P++   NG+TPLHI+ ++ 
Sbjct: 461 CLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 520

Query: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLH 442
            V V  +LL+ GA+    T+ G TPLHVA+  G L + K LLQR A+ + +     TPLH
Sbjct: 521 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 580

Query: 443 MAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA 502
           +AA   + +VA  LL+  A  +A AK+  TPLH AA+     +   LL   A  N+ T  
Sbjct: 581 VAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ 640

Query: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562
           G TPLH+A++EGH + V  LL+K A+    TK G T LH+AA+  KV VA++L +  A  
Sbjct: 641 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ 700

Query: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
           +A  K G TPL VA H+ N+ +V  LL +G + ++   NGYTPLH AA+Q    +   LL
Sbjct: 701 DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL 760

Query: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
           Q+G   NA +  G T L +A + G+  +V  L
Sbjct: 761 QHGAKPNATTANGNTALAIAKRLGYISVVDTL 792



 Score =  181 bits (459), Expect = 6e-45
 Identities = 111/335 (33%), Positives = 173/335 (51%), Gaps = 4/335 (1%)

Query: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
           V  R  +  T    A+R G  +     L++    +    NG   LH++++EG V +   L
Sbjct: 469 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 528

Query: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
           L         TKKG T LH+AA  G  +V + L+   A  ++  + G TPL++AA  ++ 
Sbjct: 529 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQ 588

Query: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIA 180
           +V   LLE GA+ +   ++G+TPL +A ++    + + L+NYG +     K  +  LH+A
Sbjct: 589 KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 648

Query: 181 ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 240
           ++   T    +LL    N  + +K+G T LH+AA  + +NVA +L   GA  +   + G 
Sbjct: 649 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 708

Query: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
           TPL +A   GNV MV  LL +GA +  KTK+  TPLH AA+ GH  I  +LL HGA   A
Sbjct: 709 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 768

Query: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335
            T NG + + +A +  ++  V  L     E+   T
Sbjct: 769 TTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTT 803



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 19/48 (39%), Positives = 30/48 (62%)

Query: 1798 QGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQE 1845
            +G++   IP E VTEE++ DE G+ V KK+ RK++R+   S     +E
Sbjct: 1776 KGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEE 1823


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score = 1743 bits (4514), Expect = 0.0
 Identities = 888/1444 (61%), Positives = 1099/1444 (76%), Gaps = 56/1444 (3%)

Query: 8    READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
            +++DA  S+LRAAR+G+L+KALD+++NGVDIN CNQNGLN LHLASKEGHV++V ELL +
Sbjct: 37   KKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQR 96

Query: 68   EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
            E  ++  TKKGNTALHIA+LAGQ EVV+ LV  GANVNAQSQ GFTPLYMAAQENHLEVV
Sbjct: 97   EANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVV 156

Query: 128  KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187
            KFLL+NGA+Q++ATEDGFTPLAVALQQGH+ VV+ L+   TKGKVRLPALHIAAR DDT+
Sbjct: 157  KFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTK 216

Query: 188  TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 247
             AA+LLQND N DV SK+GFTPLHIAAHY N+NVA LLLNR A+V+FT +N ITPLH+AS
Sbjct: 217  AAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVAS 276

Query: 248  RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307
            +RGN  MV+LLLDRGA+I+ KT+D LTPLHC AR+GH ++ E+LLD  API +KTKNGLS
Sbjct: 277  KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLS 336

Query: 308  PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367
            P+HMA QGDHL+CV+LLLQ++  +DD+T D+LT LHVAAHCGH++VAKVLLDK A PN++
Sbjct: 337  PLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAK 396

Query: 368  ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427
            ALNGFTPLHIACKKN ++VMELLLK GASI AVTESGLTP+HVA+FMGH+ IV  L+  G
Sbjct: 397  ALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHG 456

Query: 428  ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487
            ASPN +NV+ ET LHMAAR+G  EV +YL+Q+ A+V AKAKDDQTPLH +AR+G  ++V+
Sbjct: 457  ASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQ 516

Query: 488  LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 547
             LL+  A+PN ATT+G+TPLH++AREGH +    LL+  AS +  TKKGFTPLHVAAKYG
Sbjct: 517  QLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYG 576

Query: 548  KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 607
            K+ VA LLL++ A P+AAGK+GLTPLHVA H++N  +  LLL +G SPH+ A NGYTPLH
Sbjct: 577  KLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLH 636

Query: 608  IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS 667
            IAAK+NQ+++A +LL+YG  ANA + QG+  +HLAAQEGH +MV+LLL + AN NL NKS
Sbjct: 637  IAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKS 696

Query: 668  GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727
            GLTPLHL AQE  V VA+VL+  G  VDA T+MGYTPLHV  HYGNIK+V FLLQH A V
Sbjct: 697  GLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKV 756

Query: 728  NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
            NAKTK GY+PLHQAAQQGHT I+ +LL+N ASPNE++ +G T L IA+RLGYISV D LK
Sbjct: 757  NAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLK 816

Query: 788  VVTDET-SFVLVSDKHRMSFPETVDEILDVSEDE-----------GEELISFKAERRDSR 835
            +VT+ET +   V++KH+M+ PET++E+LD+S+DE             E IS   E  D+ 
Sbjct: 817  IVTEETMTTTTVTEKHKMNVPETMNEVLDMSDDEVRKANAPEMLSDGEYISDVEEGEDAM 876

Query: 836  DVDEEK------------------------------ELLDFVPKLDQVVESPAIPRIPCA 865
              D +K                               L  F       +   +  R    
Sbjct: 877  TGDTDKYLGPQDLKELGDDSLPAEGYMGFSLGARSASLRSFSSDRSYTLNRSSYARDSMM 936

Query: 866  MPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGS 925
            + E +V   E+    ++E+D DSL   S A +T DN++ V+SP+H+GFLVSFMVDARGGS
Sbjct: 937  IEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMVDARGGS 996

Query: 926  MRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQF 985
            MRGSRH+G+R++IPPR C APTRITCRLVK  KL+ PPP+ E EGLASR++ +GP GAQF
Sbjct: 997  MRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQF 1056

Query: 986  LSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEE 1045
            L PVIVEIPHF S    +REL+VLRSENG  WKEH+       L ++LNGMDEEL S EE
Sbjct: 1057 LGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEE 1116

Query: 1046 LEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVK 1105
            L KKR+CRIIT DFP YF ++SR+ Q+ + IGPEGG L S  VPLVQA+FPE A+TKR++
Sbjct: 1117 LGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIR 1176

Query: 1106 LALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEG 1165
            + LQAQPVPDE+V K+LGN+ATFSPIVTVEPRRRKFH+PI + IP+PP   +   +  +G
Sbjct: 1177 VGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKG 1236

Query: 1166 DTT-SLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVN 1224
            DTT +LRLLCS+ GGT  AQWEDITGTT L +  +C +FTTNVSARFWL+DC +  E V 
Sbjct: 1237 DTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVG 1296

Query: 1225 FATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRD 1284
             AT LY+EL  VPYMAKFV+FAKMNDP E  LRC+CMTDDKVDKTLEQ ENF EVARS+D
Sbjct: 1297 LATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKD 1356

Query: 1285 IEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLR 1344
            IEVLEG  ++ +  GNL P+ K  QQ  F+F SF+ENRL   +K+RD+S+EP G LSFL+
Sbjct: 1357 IEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLK 1416

Query: 1345 KAMKYED-TQHILCHLNITMPPCAKGSGAE--------DRRRTPTPLAL--RYSILSEST 1393
            +    +   Q  +C+LNIT+P   K + ++        DRR++   LAL  RYS L+E  
Sbjct: 1417 EPKTTKGLPQTAVCNLNITLPAHKKETESDQDDEIEKTDRRQSFASLALRKRYSYLTE-- 1474

Query: 1394 PGSL 1397
            PG +
Sbjct: 1475 PGMI 1478



 Score =  407 bits (1045), Expect = e-113
 Identities = 246/684 (35%), Positives = 363/684 (53%), Gaps = 33/684 (4%)

Query: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGH---VKM 60
           +V  +  +  T    AA+  +L+     L NG   +   ++G   L +A ++GH   V +
Sbjct: 132 NVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSL 191

Query: 61  VVE--------------------------LLHKEIILETTTKKGNTALHIAALAGQDEVV 94
           ++E                          LL  +   +  +K G T LHIAA  G   V 
Sbjct: 192 LLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVA 251

Query: 95  RELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 154
             L+N  A V+  ++   TPL++A++  +  +VK LL+ GA  +  T DG TPL    + 
Sbjct: 252 TLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARS 311

Query: 155 GHENVVAHLINYG----TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPL 210
           GHE VV  L++      +K K  L  LH+A + D      +LLQ++   D ++    T L
Sbjct: 312 GHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTAL 371

Query: 211 HIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK 270
           H+AAH  +  VA++LL++ A+ N    NG TPLHIA ++  + ++ LLL  GA I+  T+
Sbjct: 372 HVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTE 431

Query: 271 DELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
             LTP+H AA  GHV I   L+ HGA        G + +HMAA+    + VR L+Q  A+
Sbjct: 432 SGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQ 491

Query: 331 IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 390
           ++    D  TPLH++A  G   + + LL +GA PN+   +G+TPLH++ ++ H  V   L
Sbjct: 492 VEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFL 551

Query: 391 LKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHT 450
           L  GAS+   T+ G TPLHVA+  G L +   LLQ+ ASP+ +     TPLH+AA   + 
Sbjct: 552 LDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQ 611

Query: 451 EVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510
           +VA  LL   A  +A AK+  TPLH AA+    ++   LLE  A+ N  T  G   +H+A
Sbjct: 612 KVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLA 671

Query: 511 AREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 570
           A+EGHV+ V  LL + A+     K G TPLH+AA+  +V VAE+L+ + AH +A  K G 
Sbjct: 672 AQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGY 731

Query: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
           TPLHV  H+ N+ IV  LL      ++   NGYTPLH AA+Q    +   LLQ   S N 
Sbjct: 732 TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNE 791

Query: 631 ESVQGVTPLHLAAQEGHAEMVALL 654
            +V G T L +A + G+  +V  L
Sbjct: 792 LTVNGNTALGIARRLGYISVVDTL 815



 Score =  215 bits (547), Expect = 4e-55
 Identities = 123/358 (34%), Positives = 191/358 (53%), Gaps = 29/358 (8%)

Query: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517
           + +++   K  D       AAR GH       ++N  + N+    G   LH+A++EGHVE
Sbjct: 29  RKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVE 88

Query: 518 TVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 577
            V  LL++EA+    TKKG T LH+A+  G+  V ++L+   A+ NA  +NG TPL++A 
Sbjct: 89  VVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAA 148

Query: 578 HHNNLDIVKLLLPRGGSPHSPAWNGYTP-----------------------------LHI 608
             N+L++VK LL  G S      +G+TP                             LHI
Sbjct: 149 QENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHI 208

Query: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
           AA+++  + A  LLQ   +A+ ES  G TPLH+AA  G+  +  LLL++ A  +   ++ 
Sbjct: 209 AARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND 268

Query: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
           +TPLH+ ++ G+  +  +L+  G  +DA TR G TPLH  +  G+ ++V+ LL   A + 
Sbjct: 269 ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPIL 328

Query: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
           +KTK G SPLH A Q  H + V LLL++    ++V++D  T L +A   G+  V  VL
Sbjct: 329 SKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386



 Score =  107 bits (268), Expect = 8e-23
 Identities = 59/144 (40%), Positives = 83/144 (57%), Gaps = 5/144 (3%)

Query: 1365 PCAKGSGAEDRRRTPTPLALRYSIL-----SESTPGSLSGTEQAEMKMAVISEHLGLSWA 1419
            P      A D++    PL  +         S    G  S  E+ +++MA++++HLGLSW 
Sbjct: 4047 PSVTTKSARDKKTEAAPLKSKSEKAGSEKRSSRRTGPQSPCERTDIRMAIVADHLGLSWT 4106

Query: 1420 ELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEI 1479
            ELAREL FSV++IN+IRVENPNSL+ QS  LL  WV R+G+NA  + L + L  I+R +I
Sbjct: 4107 ELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDI 4166

Query: 1480 VNMLEGSGRQSRNLKPDRRHTDRD 1503
            V +LEG      N+   R   D +
Sbjct: 4167 VTLLEGPIFDYGNISGTRSFADEN 4190


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score = 1678 bits (4346), Expect = 0.0
 Identities = 866/1496 (57%), Positives = 1098/1496 (73%), Gaps = 79/1496 (5%)

Query: 8    READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
            +++D+  SFLRAAR+GNLDK +++L+ G+DINTCNQNGLN LHLA+KEGHV +V ELL +
Sbjct: 27   KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86

Query: 68   EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
               +++ TKKGNTALHIA+LAGQ EVV+ LV  GAN+NAQSQ GFTPLYMAAQENH++VV
Sbjct: 87   GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146

Query: 128  KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187
            K+LLENGANQ+ ATEDGFTPLAVALQQGH   VA L+   TKGKVRLPALHIAAR DDT+
Sbjct: 147  KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 206

Query: 188  TAAVLLQNDPNPDVLSK--------TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
            +AA+LLQND N DV SK        +GFTPLHIAAHY N+NVA LLLNRGA+V+FT +NG
Sbjct: 207  SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 266

Query: 240  ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
            ITPLH+AS+RGN  MV+LLLDRG QI+ KT+D LTPLHCAAR+GH ++ E+LL+ GAP+ 
Sbjct: 267  ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 326

Query: 300  AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
            A+TKNGLSP+HMAAQGDH++CV+ LLQ+ A +DD+TLD+LT LHVAAHCGH+RV K+LLD
Sbjct: 327  ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 386

Query: 360  KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
            K A PN+RALNGFTPLHIACKKN ++VMELL+K GASI A+TESGLTP+HVA+FMGHL I
Sbjct: 387  KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 446

Query: 420  VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
            V  LLQ GASP+V+N++ ET LHMAARAG  EV + LL+N A V+A+A+++QTPLH A+R
Sbjct: 447  VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 506

Query: 480  IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
            +G T +V+LLL++ A+P+ ATT G+TPLHI+AREG V+    LLE  A+ +  TKKGFTP
Sbjct: 507  LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 566

Query: 540  LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
            LHVAAKYG + VA+LLL+R A  ++AGKNGLTPLHVA H++N  +  LLL +G SPH+ A
Sbjct: 567  LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626

Query: 600  WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
             NGYTPLHIAAK+NQ+++A +LL YG   N  + QGVTPLHLA+QEGH +MV LLL K A
Sbjct: 627  KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 686

Query: 660  NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719
            N ++  KSGLT LHL AQE  V VAD+L KHG   DA T++GYTPL VA HYGN+K+V F
Sbjct: 687  NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 746

Query: 720  LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779
            LL+  A+VNAKTK GY+PLHQAAQQGHT I+ +LL++GA PN  +++G T LAIAKRLGY
Sbjct: 747  LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 806

Query: 780  ISVTDVLKVVTDE--TSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAER------ 831
            ISV D LKVVT+E  T+   +++KH+++ PET+ E+LDVS++EG++ ++           
Sbjct: 807  ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPED 866

Query: 832  ---------------------RDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETV 870
                                 R S +      L  F       +   +  R    M ++V
Sbjct: 867  LKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSV 926

Query: 871  VIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSR 930
            VI S +    +KE + +S    S  TE  DN++  +SP+H+GFLVSFMVDARGG+MRG R
Sbjct: 927  VIPSHQVSTLAKEAERNS-YRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCR 985

Query: 931  HNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQ------ 984
            HNGLR++IPPR C APTR+TCRLVK  +L+T PP+ E EGLASR+I +GP+GAQ      
Sbjct: 986  HNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGKLH 1045

Query: 985  ---------------------------FLSPVIVEIPHFASHGRGDRELVVLRSENGSVW 1017
                                       FL PVIVEIPHFA+    +RELVVLRSENG  W
Sbjct: 1046 LPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVVLRSENGDSW 1105

Query: 1018 KEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIG 1077
            KEH   Y E  L++ILNGMDE L S E+LEKKR+CRIIT DFP YF ++SR+ QD + IG
Sbjct: 1106 KEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIG 1165

Query: 1078 PEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPR 1137
            PEGG L S +VP VQA FPE A+TKR+++ LQAQP+  ELV K+LGN+ATFSPIVT+EPR
Sbjct: 1166 PEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPR 1225

Query: 1138 RRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYA 1197
            RRKFH+PI + IP+P + +D   +   GD  +LRLLCS+ GGT  AQWEDITGTT L + 
Sbjct: 1226 RRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFV 1285

Query: 1198 NECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLR 1257
            NEC +FTTNVSARFWL DC +  E+V FA+ +Y+E+  VPYMAKFV+FAK +DP E RLR
Sbjct: 1286 NECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLR 1345

Query: 1258 CYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQS 1317
            C+CMTDDKVDKTLEQ ENF EVARSRD+EVLEG  ++ +  GNLVP+ K+ Q   F F +
Sbjct: 1346 CFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFA 1405

Query: 1318 FRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQH-ILCHLNITMPPCAKGSGAEDRR 1376
            F+ENRL + VKVRD+++EP G LSF+++        H  +C+LNIT+P   K S ++  +
Sbjct: 1406 FKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQ 1465

Query: 1377 RTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDI 1432
                 +    +  +ES       TE + +K  +++E   L+  +L  E+    +D+
Sbjct: 1466 EEEIDMTSEKNDETES-------TETSVLKSHLVNEVPVLASPDLLSEVSEMKQDL 1514



 Score =  404 bits (1038), Expect = e-112
 Identities = 245/692 (35%), Positives = 368/692 (53%), Gaps = 41/692 (5%)

Query: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
           ++  +  +  T    AA+  ++D     L NG + +T  ++G   L +A ++GH + V  
Sbjct: 122 NINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAI 181

Query: 64  LLHKE-------------------------------------IILETTTKKGNTALHIAA 86
           LL  +                                     +++  TT+ G T LHIAA
Sbjct: 182 LLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAA 241

Query: 87  LAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFT 146
             G   V   L+N GA V+  ++ G TPL++A++  +  +VK LL+ G   +  T DG T
Sbjct: 242 HYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLT 301

Query: 147 PLAVALQQGHENVVAHLINYG----TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL 202
           PL  A + GH+ VV  L+  G     + K  L  LH+AA+ D       LLQ+    D +
Sbjct: 302 PLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDV 361

Query: 203 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 262
           +    T LH+AAH  +  V +LLL++ A+ N    NG TPLHIA ++  + ++ LL+  G
Sbjct: 362 TLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYG 421

Query: 263 AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR 322
           A I+  T+  LTP+H AA  GH+ I  +LL +GA        G + +HMAA+   ++ VR
Sbjct: 422 ASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVR 481

Query: 323 LLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382
            LL+  A +D    +  TPLH+A+  G   + ++LL   A P++   NG+TPLHI+ ++ 
Sbjct: 482 CLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541

Query: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLH 442
            V V  +LL+ GA+    T+ G TPLHVA+  G L + K LLQR A+ + +     TPLH
Sbjct: 542 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 601

Query: 443 MAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA 502
           +AA   + +VA  LL+  A  +A AK+  TPLH AA+     +   LL   A  N+ T  
Sbjct: 602 VAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ 661

Query: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562
           G TPLH+A++EGH + V  LL+K A+    TK G T LH+AA+  KV VA++L +  A  
Sbjct: 662 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ 721

Query: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
           +A  K G TPL VA H+ N+ +V  LL +G + ++   NGYTPLH AA+Q    +   LL
Sbjct: 722 DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL 781

Query: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
           Q+G   NA +  G T L +A + G+  +V  L
Sbjct: 782 QHGAKPNATTANGNTALAIAKRLGYISVVDTL 813



 Score =  201 bits (512), Expect = 4e-51
 Identities = 120/329 (36%), Positives = 178/329 (54%), Gaps = 12/329 (3%)

Query: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAARE 513
           K+   ++ +   K  D       AAR G+ + V   L+   + N     G   LH+AA+E
Sbjct: 15  KFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKE 74

Query: 514 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 573
           GHV  V  LL + +S    TKKG T LH+A+  G+  V ++L++  A+ NA  +NG TPL
Sbjct: 75  GHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 134

Query: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 633
           ++A   N++D+VK LL  G +  +   +G+TPL +A +Q   +    LL+          
Sbjct: 135 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR-- 192

Query: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK--------SGLTPLHLVAQEGHVPVAD 685
             +  LH+AA++   +  ALLL    N ++ +K        SG TPLH+ A  G+V VA 
Sbjct: 193 --LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250

Query: 686 VLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQG 745
           +L+  G  VD T R G TPLHVAS  GN  +VK LL     ++AKT+ G +PLH AA+ G
Sbjct: 251 LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSG 310

Query: 746 HTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
           H  +V LLL+ GA     + +G +PL +A
Sbjct: 311 HDQVVELLLERGAPLLARTKNGLSPLHMA 339



 Score =  181 bits (459), Expect = 6e-45
 Identities = 111/335 (33%), Positives = 173/335 (51%), Gaps = 4/335 (1%)

Query: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
           V  R  +  T    A+R G  +     L++    +    NG   LH++++EG V +   L
Sbjct: 490 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549

Query: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
           L         TKKG T LH+AA  G  +V + L+   A  ++  + G TPL++AA  ++ 
Sbjct: 550 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQ 609

Query: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIA 180
           +V   LLE GA+ +   ++G+TPL +A ++    + + L+NYG +     K  +  LH+A
Sbjct: 610 KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 669

Query: 181 ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 240
           ++   T    +LL    N  + +K+G T LH+AA  + +NVA +L   GA  +   + G 
Sbjct: 670 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 729

Query: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
           TPL +A   GNV MV  LL +GA +  KTK+  TPLH AA+ GH  I  +LL HGA   A
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789

Query: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335
            T NG + + +A +  ++  V  L     E+   T
Sbjct: 790 TTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTT 824



 Score = 95.5 bits (236), Expect = 4e-19
 Identities = 49/121 (40%), Positives = 79/121 (65%), Gaps = 1/121 (0%)

Query: 1401 EQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQ 1460
            E+ E ++A I++HLG SW ELAREL F+ E I++IR+ENPNSL +QS ALL  W+ R+G+
Sbjct: 3567 ERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGK 3626

Query: 1461 NANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDE 1520
            +A   NL   L  I+R +IV+++E +  +    +    + + + +++     G+S LQ+E
Sbjct: 3627 HATDTNLVECLTKINRMDIVHLME-TNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEE 3685

Query: 1521 L 1521
            L
Sbjct: 3686 L 3686



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 19/48 (39%), Positives = 30/48 (62%)

Query: 1798 QGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQE 1845
            +G++   IP E VTEE++ DE G+ V KK+ RK++R+   S     +E
Sbjct: 3870 KGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEE 3917


>gi|32967599 ankyrin 3 isoform 2 [Homo sapiens]
          Length = 1001

 Score =  775 bits (2001), Expect = 0.0
 Identities = 405/733 (55%), Positives = 523/733 (71%), Gaps = 7/733 (0%)

Query: 866  MPETVVIRSEEQEQA-SKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGG 924
            M E +++ S+EQ    ++E+D DSL   S A +T DN++ V+SP+H+GFLVSFMVDARGG
Sbjct: 70   MIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMVDARGG 129

Query: 925  SMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQ 984
            SMRGSRH+G+R++IPPR C APTRITCRLVK  KL+ PPP+ E EGLASR++ +GP GAQ
Sbjct: 130  SMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQ 189

Query: 985  FLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLE 1044
            FL PVIVEIPHF S    +REL+VLRSENG  WKEH+       L ++LNGMDEEL S E
Sbjct: 190  FLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPE 249

Query: 1045 ELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRV 1104
            EL KKR+CRIIT DFP YF ++SR+ Q+ + IGPEGG L S  VPLVQA+FPE A+TKR+
Sbjct: 250  ELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRI 309

Query: 1105 KLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGE 1164
            ++ LQAQPVPDE+V K+LGN+ATFSPIVTVEPRRRKFH+PI + IP+PP   +   +  +
Sbjct: 310  RVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYK 369

Query: 1165 GDTT-SLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAV 1223
            GDTT +LRLLCS+ GGT  AQWEDITGTT L +  +C +FTTNVSARFWL+DC +  E V
Sbjct: 370  GDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETV 429

Query: 1224 NFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSR 1283
              AT LY+EL  VPYMAKFV+FAKMNDP E  LRC+CMTDDKVDKTLEQ ENF EVARS+
Sbjct: 430  GLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSK 489

Query: 1284 DIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFL 1343
            DIEVLEG  ++ +  GNL P+ K  QQ  F+F SF+ENRL   +K+RD+S+EP G LSFL
Sbjct: 490  DIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFL 549

Query: 1344 RKAMKYED-TQHILCHLNITMPPCAKGSGAEDRRRTPTPLAL--RYSILSESTPGSLSGT 1400
            ++    +   Q  +C+LNIT+ P  K     DRR++   LAL  RYS L+E      S  
Sbjct: 550  KEPKTTKGLPQTAVCNLNITL-PAHKKIEKTDRRQSFASLALRKRYSYLTEPGMSPQSPC 608

Query: 1401 EQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQ 1460
            E+ +++MA++++HLGLSW ELAREL FSV++IN+IRVENPNSL+ QS  LL  WV R+G+
Sbjct: 609  ERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGK 668

Query: 1461 NANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDE 1520
            NA  + L + L  I+R +IV +LEG      N+   R   D + ++    ++GY SLQ E
Sbjct: 669  NATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADEN-NVFHDPVDGYPSLQVE 727

Query: 1521 LLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTA 1580
            L +P  L     +P + D Y+++++ +++     +     L  S   +  +   P +VTA
Sbjct: 728  LETPTGLHYTPPTPFQQDDYFSDISSIESPLRTPSRLSDGLVPSQGNIEHSADGPPVVTA 787

Query: 1581 EDSSLECSKAEDS 1593
            ED+SLE SK EDS
Sbjct: 788  EDASLEDSKLEDS 800


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  332 bits (852), Expect = 2e-90
 Identities = 261/832 (31%), Positives = 380/832 (45%), Gaps = 99/832 (11%)

Query: 37  DINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRE 96
           ++N  ++ G   LH A+  GH +MV  LL +   +    KK   A+H AA  G  EVV+ 
Sbjct: 132 NVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKL 191

Query: 97  LVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGH 156
           LV++GA V  + +K +TPL+ AA    + VVK+LL+ G + N     G TPL VA   G 
Sbjct: 192 LVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQ 251

Query: 157 ENVVAHLINYGT----KGKVRLPALHIAARNDDTRTAAVLLQ-NDPNPDVLSKTGFTPLH 211
           + VV  LI+ G     K +     LH AA +        LL  N  + ++ SK G TPLH
Sbjct: 252 DVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLH 311

Query: 212 IAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV---------------- 255
           + A +   + +Q ++  GA ++   +NG TPLHIA+R G+ +++                
Sbjct: 312 MTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIH 371

Query: 256 -----------------RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
                            R LL  G  I+T      T LH AA  G++    +LL+ GA  
Sbjct: 372 GMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADF 431

Query: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH-RVAKVL 357
             K K G SP+H AA   +  C+  L+   A ++D+     TPLH AA      +  + L
Sbjct: 432 NKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYL 491

Query: 358 LDKGAKPNSRALNGF--------------------------------------------- 372
           L   A P  R   G+                                             
Sbjct: 492 LRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATI 551

Query: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
           +PLH+A    H + +E+L+++   +D    SG TPL +A+F GH+  V  L+ +GAS  V
Sbjct: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611

Query: 433 SN-VKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD---QTPLHCAARIGHTNMVKL 488
            + +   TP+H AA  GH+E  + L+ N    NA    D   QTPL  +   GHT+ V  
Sbjct: 612 KDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYS 671

Query: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK 548
           LL   AN +     G T LH  A  GH E V ALL+  A       +G TP+H++A  G 
Sbjct: 672 LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGH 731

Query: 549 VRVAELLLER----DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 604
           + V   LL+     DA+P  A  +G T LH A ++ +   V+LLL +     +   N ++
Sbjct: 732 IGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEG-NAFS 790

Query: 605 PLHIAAKQNQVEVARSLLQYGGSA--NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
           PLH A   +    A  L+   G++  NA   +G TPLH AA   H E + LLLS  A  N
Sbjct: 791 PLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVN 850

Query: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHG-VMVDATTRMGYTPLHVASHYGNIKLVKFLL 721
             + +G TPL + A+ G     ++L+      +        T LH+A   G+      +L
Sbjct: 851 SVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLIL 910

Query: 722 QHQAD---VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 770
           +   D   +NA      +PLH AA+ G T +V  LL  GAS   V  +G TP
Sbjct: 911 EKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 962



 Score =  327 bits (839), Expect = 5e-89
 Identities = 248/812 (30%), Positives = 388/812 (47%), Gaps = 33/812 (4%)

Query: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
           V  +++   T   RA  S + +     L++  D+N  ++N    LH+A+    VK    L
Sbjct: 67  VNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126

Query: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
           +     +  + + G TALH AA +G  E+V+ L++ GAN+NA  +K    ++ AA   H+
Sbjct: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHI 186

Query: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIA 180
           EVVK L+ +GA      +  +TPL  A   G  +VV +L++ G             LH+A
Sbjct: 187 EVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVA 246

Query: 181 ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI-AAHYENLNVAQLLLNRGASVNFTPQNG 239
             N        L+      +  ++ GFTPLH  AA        +LL+  GA VN   ++G
Sbjct: 247 CYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDG 306

Query: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
            TPLH+ +  G     + ++  GA I+ + K+  TPLH AAR GH  +   L+  GA   
Sbjct: 307 KTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTA 366

Query: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
            +  +G+ P+H+AA     DC R LL    +ID       T LH AA  G+     +LL+
Sbjct: 367 KRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLN 426

Query: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMG-HLP 418
            GA  N +   G +PLH A    + + +  L+ +GAS++ + E G TPLH A+       
Sbjct: 427 TGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGK 486

Query: 419 IVKNLLQRGASPNVSNVKVETPLHMAARAGH--------TEVAKYLLQNKAKVNAKAKDD 470
            ++ LL+  A+P + + +    +H +A  GH        +E    +L   +  +  +  D
Sbjct: 487 CLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSD 546

Query: 471 Q----TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526
                +PLH AA  GH   +++L+++  + ++  ++G TPL +AA +GHVE V  L+ + 
Sbjct: 547 NRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQG 606

Query: 527 AS---QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA---GKNGLTPLHVAVHHN 580
           AS   +  + K+  TP+H AA  G      LL+      NA      NG TPL ++V + 
Sbjct: 607 ASILVKDYILKR--TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNG 664

Query: 581 NLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLH 640
           + D V  LL +G +  +    G T LH  A     E   +LLQ+G        +G TP+H
Sbjct: 665 HTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIH 724

Query: 641 LAAQEGHAEMVALLL----SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696
           L+A  GH  ++  LL    S  AN    +  G T LH     GH    ++L++  V    
Sbjct: 725 LSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVF-QK 783

Query: 697 TTRMGYTPLHVASHYGNIKLVKFLLQ--HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
           T    ++PLH A    N    + L+     + VNA    G +PLH AA   H + + LLL
Sbjct: 784 TEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLL 843

Query: 755 KNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
            + A  N V S G TPL +A   G  +  ++L
Sbjct: 844 SHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875



 Score =  308 bits (790), Expect = 2e-83
 Identities = 233/767 (30%), Positives = 365/767 (47%), Gaps = 26/767 (3%)

Query: 15  SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
           S ++A  +G+ D+    +    D+N  +      LH A+  G  +++  L+     +   
Sbjct: 11  SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70

Query: 75  TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134
             K  T LH A  +  +E V+ L+ + A+VNA+ +   TPL++AA    ++  + L+   
Sbjct: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130

Query: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAA 190
           +N NV+   G T L  A   GH  +V  L++ G       K    A+H AA         
Sbjct: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 190

Query: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
           +L+ +        K  +TPLH AA    ++V + LL+ G  +N     G TPLH+A   G
Sbjct: 191 LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 250

Query: 251 NVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS-EILLDHGAPIQAKTKNGLSPI 309
             ++V  L+D GA +  K +   TPLH AA + H  +  E+L+ +GA +  K+K+G +P+
Sbjct: 251 QDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPL 310

Query: 310 HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369
           HM A        + ++Q  A ID    +  TPLH+AA  GH  +   L+  GA    R +
Sbjct: 311 HMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGI 370

Query: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429
           +G  PLH+A           LL +G  ID   + G T LH A+  G+L  +  LL  GA 
Sbjct: 371 HGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGAD 430

Query: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG-HTNMVKL 488
            N  +    +PLH AA   + +    L+ + A VN   +   TPLH AA        ++ 
Sbjct: 431 FNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEY 490

Query: 489 LLENNANPNLATTAGHTPLHIAAREGH--------VETVLALLEKEASQACMT----KKG 536
           LL N+ANP +    G+  +H +A  GH         ET L +L + +    ++    +  
Sbjct: 491 LLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRAT 550

Query: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
            +PLH+AA +G  +  E+L++     +    +G TPL +A    +++ V +L+ +G S  
Sbjct: 551 ISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASIL 610

Query: 597 SPAW-NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ---GVTPLHLAAQEGHAEMVA 652
              +    TP+H AA     E  R L+      NA  +Q   G TPL L+   GH + V 
Sbjct: 611 VKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVY 670

Query: 653 LLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYG 712
            LL+K AN +  +K G T LH  A  GH    D L++HG         G TP+H+++  G
Sbjct: 671 SLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACG 730

Query: 713 NIKLVKFLLQHQADVNAKTKL----GYSPLHQAAQQGHTDIVTLLLK 755
           +I ++  LLQ  A ++A        GY+ LH A   GH   V LLL+
Sbjct: 731 HIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLE 777



 Score =  290 bits (741), Expect = 1e-77
 Identities = 222/753 (29%), Positives = 339/753 (45%), Gaps = 80/753 (10%)

Query: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
           A   G  + VR L+    +VN Q  +  TPL+ AA     E+++ L+ +GA  N      
Sbjct: 15  AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 74

Query: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
            TPL                             H A  +       VLL++  + +   K
Sbjct: 75  LTPL-----------------------------HRAVASCSEEAVQVLLKHSADVNARDK 105

Query: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
              TPLHIAA  + +  A+ L+   ++VN + + G T LH A+  G+  MV+LLL RGA 
Sbjct: 106 NWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGAN 165

Query: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
           I    K +   +H AA  GH+ + ++L+ HGA +  K K   +P+H AA    +  V+ L
Sbjct: 166 INAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYL 225

Query: 325 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH- 383
           L    ++++      TPLHVA + G   V   L+D GA  N +   GFTPLH A    H 
Sbjct: 226 LDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHG 285

Query: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443
              +ELL+  GA ++  ++ G TPLH+ +  G     + ++Q GA  +  +    TPLH+
Sbjct: 286 ALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHI 345

Query: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503
           AAR GH  +   L+ + A    +      PLH AA  G ++  + LL +  + +     G
Sbjct: 346 AARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFG 405

Query: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
            T LH AA  G++E +  LL   A      K G +PLH AA     +    L+   A  N
Sbjct: 406 RTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVN 465

Query: 564 AAGKNGLTPLH-VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ---VEVAR 619
              + G TPLH  A    +   ++ LL    +P      GY  +H +A       +++  
Sbjct: 466 DLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIA 525

Query: 620 S------LLQYGGS---ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLT 670
           S      L++  G+   +++++   ++PLHLAA  GH + + +L+    + ++ N SG T
Sbjct: 526 SETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRT 585

Query: 671 PLHLVAQEGHVPVADVLIKHGV-------------------------------------M 693
           PL L A +GHV   DVLI  G                                       
Sbjct: 586 PLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNA 645

Query: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
           VD     G TPL ++   G+   V  LL   A+V+AK K G + LH+ A  GH + V  L
Sbjct: 646 VDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDAL 705

Query: 754 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
           L++GA      S G TP+ ++   G+I V   L
Sbjct: 706 LQHGAKCLLRDSRGRTPIHLSAACGHIGVLGAL 738



 Score =  273 bits (699), Expect = 9e-73
 Identities = 192/600 (32%), Positives = 290/600 (48%), Gaps = 16/600 (2%)

Query: 175 PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234
           P+L  A  N D      L+    + +       TPLH AA+  +  + +LL+  GA VN 
Sbjct: 10  PSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNA 69

Query: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294
                +TPLH A    +   V++LL   A +  + K+  TPLH AA N  V+ +E L+  
Sbjct: 70  KDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPL 129

Query: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354
            + +    + G + +H AA   H + V+LLL   A I+         +H AA+ GH  V 
Sbjct: 130 LSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVV 189

Query: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414
           K+L+  GA+   +    +TPLH A     + V++ LL  G  ++     G TPLHVA + 
Sbjct: 190 KLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYN 249

Query: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA-KYLLQNKAKVNAKAKDDQTP 473
           G   +V  L+  GA  N  N K  TPLH AA + H  +  + L+ N A VN K+KD +TP
Sbjct: 250 GQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTP 309

Query: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
           LH  A  G  +  + ++++ A  +     G+TPLHIAAR GH   +  L+   A  A   
Sbjct: 310 LHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRG 369

Query: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
             G  PLH+AA  G       LL      +     G T LH A    NL+ + LLL  G 
Sbjct: 370 IHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGA 429

Query: 594 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA-QEGHAEMVA 652
             +     G +PLH AA     +   +L+  G S N    +G TPLH AA  +   + + 
Sbjct: 430 DFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLE 489

Query: 653 LLLSKQANGNLGNKSGLTPLHLVAQEGH----------VPVADVLIKHG---VMVDATTR 699
            LL   AN  + +K G   +H  A  GH           P+ DVL++     ++ D+  R
Sbjct: 490 YLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPL-DVLMETSGTDMLSDSDNR 548

Query: 700 MGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGAS 759
              +PLH+A+++G+ + ++ L+Q   D++ +   G +PL  AA +GH + V +L+  GAS
Sbjct: 549 ATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGAS 608



 Score =  259 bits (662), Expect = 2e-68
 Identities = 181/590 (30%), Positives = 280/590 (47%), Gaps = 17/590 (2%)

Query: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 284
           L+ +   VNF      TPLH A+  G+  ++ LL+  GA++  K    LTPLH A  +  
Sbjct: 27  LIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCS 86

Query: 285 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHV 344
               ++LL H A + A+ KN  +P+H+AA    + C   L+   + ++       T LH 
Sbjct: 87  EEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHH 146

Query: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404
           AA  GH  + K+LL +GA  N+        +H A    H+ V++LL+  GA +    +  
Sbjct: 147 AAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS 206

Query: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464
            TPLH A+  G + +VK LL  G   N  N    TPLH+A   G   V   L+   A VN
Sbjct: 207 YTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVN 266

Query: 465 AKAKDDQTPLHCAARIGHTNM-VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523
            K +   TPLH AA   H  + ++LL+ N A+ N+ +  G TPLH+ A  G       ++
Sbjct: 267 QKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTII 326

Query: 524 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD 583
           +  A   C  K G TPLH+AA+YG   +   L+   A     G +G+ PLH+A      D
Sbjct: 327 QSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSD 386

Query: 584 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643
             + LL  G    +P   G T LH AA    +E    LL  G   N +   G +PLH AA
Sbjct: 387 CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446

Query: 644 QEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA-QEGHVPVADVLIKHGVMVDATTRMGY 702
              + + +  L+   A+ N  ++ G TPLH  A  +      + L+++        + GY
Sbjct: 447 ANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGY 506

Query: 703 TPLHVASHYGNIKLVKFLL-QHQADVNAKT-----------KLGYSPLHQAAQQGHTDIV 750
             +H ++ YG+   ++ +  +   DV  +T           +   SPLH AA  GH   +
Sbjct: 507 NAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQAL 566

Query: 751 TLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 800
            +L+++    +  +S G TPL +A   G++   DVL    ++ + +LV D
Sbjct: 567 EVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL---INQGASILVKD 613



 Score =  236 bits (602), Expect = 2e-61
 Identities = 192/682 (28%), Positives = 299/682 (43%), Gaps = 65/682 (9%)

Query: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
           V  +  D  T     A  G   ++   +++G  I+  ++NG   LH+A++ GH  ++  L
Sbjct: 299 VNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTL 358

Query: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
           +            G   LH+AAL+G  +  R+L++ G +++     G T L+ AA   +L
Sbjct: 359 ITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNL 418

Query: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIA 180
           E +  LL  GA+ N   + G +PL  A    +   +  L+  G       +     LH A
Sbjct: 419 ECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYA 478

Query: 181 ARND-DTRTAAVLLQNDPNPDVLSKTGF-------------------------------- 207
           A +D D +    LL+ND NP +  K G+                                
Sbjct: 479 ATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSG 538

Query: 208 -------------TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIM 254
                        +PLH+AA++ +    ++L+     ++    +G TPL +A+ +G+V  
Sbjct: 539 TDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVEC 598

Query: 255 VRLLLDRGAQIETKTKD-ELTPLHCAARNGHVRISEILLDHGAP---IQAKTKNGLSPIH 310
           V +L+++GA I  K    + TP+H AA NGH     +L+ +  P   +  +  NG +P+ 
Sbjct: 599 VDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLM 658

Query: 311 MAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370
           ++    H DCV  LL   A +D       T LH  A  GH      LL  GAK   R   
Sbjct: 659 LSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSR 718

Query: 371 GFTPLHIACKKNHVRVMELLLKTGASIDA----VTESGLTPLHVASFMGHLPIVKNLLQR 426
           G TP+H++    H+ V+  LL++ AS+DA        G T LH A + GH   V+ LL++
Sbjct: 719 GRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQ 778

Query: 427 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK--VNAKAKDDQTPLHCAARIGHTN 484
                       +PLH A    +   A+ L+       VNA     +TPLH AA   H  
Sbjct: 779 EVFQKTEG-NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVE 837

Query: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF-TPLHVA 543
            ++LLL +NA  N   + G TPL +AA  G   TV  L+   +++  +      T LH+A
Sbjct: 838 CLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLA 897

Query: 544 AKYGKVRVAELLLERDAHPNAAGKNGL---TPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600
              G    A L+LE+    N          TPLHVA  +    +V+ LL +G S  +   
Sbjct: 898 CSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDE 957

Query: 601 NGYTPLHIAAKQNQVEVARSLL 622
           NGYTP    A    V    +L+
Sbjct: 958 NGYTPALACAPNKDVADCLALI 979



 Score =  149 bits (377), Expect = 2e-35
 Identities = 107/313 (34%), Positives = 145/313 (46%), Gaps = 1/313 (0%)

Query: 470 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529
           DQ  L  A   G  + V+ L+    + N       TPLH AA  G  E +  L+   A  
Sbjct: 8   DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67

Query: 530 ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
                K  TPLH A         ++LL+  A  NA  KN  TPLH+A  +  +   + L+
Sbjct: 68  NAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALV 127

Query: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649
           P   + +     G T LH AA     E+ + LL  G + NA   +    +H AA  GH E
Sbjct: 128 PLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIE 187

Query: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
           +V LL+S  A     +K   TPLH  A  G + V   L+  GV ++     G TPLHVA 
Sbjct: 188 VVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVAC 247

Query: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI-VTLLLKNGASPNEVSSDGT 768
           + G   +V  L+   A VN K + G++PLH AA   H  + + LL+ NGA  N  S DG 
Sbjct: 248 YNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGK 307

Query: 769 TPLAIAKRLGYIS 781
           TPL +    G  S
Sbjct: 308 TPLHMTALHGRFS 320


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  327 bits (837), Expect = 9e-89
 Identities = 257/834 (30%), Positives = 387/834 (46%), Gaps = 51/834 (6%)

Query: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
           T   RA  S + +     +++  D+N  ++N    LH+A+    VK    ++     +  
Sbjct: 51  TPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV 110

Query: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
           + + G TALH AAL G  E+V  L+  GAN+NA  +K    L+ AA   HL+VV  L+ +
Sbjct: 111 SDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINH 170

Query: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK-GKVRL---PALHIAARNDDTRTA 189
           GA      + G+TPL  A   G  NVV HL+N G +  ++ +    ALHIA  N      
Sbjct: 171 GAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVV 230

Query: 190 AVLLQNDPNPDVLSKTGFTPLHI-AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248
             L+    N +  +  GFTPLH  AA        +LL+N GA VN   ++G +PLH+ + 
Sbjct: 231 NELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAV 290

Query: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308
            G     + L+  G +I+   KD  TPLH AAR GH  +   L   GA       + + P
Sbjct: 291 HGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFP 350

Query: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
           +H+AA   H DC R LL    EID       T LH AA  G+    K+L   GA  + + 
Sbjct: 351 LHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKD 410

Query: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA---------SFMGHLP- 418
             G TPLH A    H   +E L+ TGA+++   + G T LH A         + +G+   
Sbjct: 411 KCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHD 470

Query: 419 ------------------IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ-- 458
                              ++ LLQ  A+P++ + +    +H AA  GH +  + LL+  
Sbjct: 471 NSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERT 530

Query: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVET 518
           N     + +   ++PLH AA  GH   +++LL++  + ++    G T L +AA +GH E 
Sbjct: 531 NSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTEC 590

Query: 519 VLALLEKEAS---QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA---GKNGLTP 572
           V AL+   AS   +  +TK+  TPLH +   G      LLLE   +P A       G TP
Sbjct: 591 VEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTP 648

Query: 573 LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 632
           L +AV + ++D V LLL +  +  +    G T LH        E  + LL+   S   + 
Sbjct: 649 LMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKD 708

Query: 633 VQGVTPLHLAAQEGHAEMVALLLS---KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
            +G TPLH AA  GHA  ++ LL     + +    +  G TPLH     G+    +VL++
Sbjct: 709 SRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE 768

Query: 690 HGVMVDATTRMGYTPLHVA--SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 747
                       +TPLH A  + +GN   +       + V+ +   G +PL  AA   H 
Sbjct: 769 QKCFRKFIGN-PFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHV 827

Query: 748 DIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 801
           + + LLL++ A  N V + G T L +A   G     D+L  V    + + V DK
Sbjct: 828 ECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL--VNSAQADLTVKDK 879



 Score =  313 bits (801), Expect = 1e-84
 Identities = 241/783 (30%), Positives = 353/783 (45%), Gaps = 83/783 (10%)

Query: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
           AA  G+LD     + +G ++   ++ G   LH A+  G + +V  LL+  + ++     G
Sbjct: 155 AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG 214

Query: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV-VKFLLENGANQ 137
           NTALHIA   GQD VV EL++YGANVN  +  GFTPL+ AA   H  + ++ L+ NGA+ 
Sbjct: 215 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADV 274

Query: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 197
           N+ ++DG +PL                             H+ A +     +  L+QN  
Sbjct: 275 NIQSKDGKSPL-----------------------------HMTAVHGRFTRSQTLIQNGG 305

Query: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 257
             D + K G TPLH+AA Y +  +   L   GA       + + PLH+A+   +    R 
Sbjct: 306 EIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRK 365

Query: 258 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH 317
           LL  G +I+T  K   T LH AA  G+V   ++L   GA    K K G +P+H AA   H
Sbjct: 366 LLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCH 425

Query: 318 LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL-------------------- 357
             C+  L+   A +++      T LH AA     R   +L                    
Sbjct: 426 FHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKE 485

Query: 358 --------LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLT--P 407
                   L   A P+ R   G+  +H A    H + +ELLL+   S    ++SG T  P
Sbjct: 486 ATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSP 545

Query: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
           LH+A++ GH   ++ LLQ     ++ + K  T L +AA  GHTE  + L+   A +  K 
Sbjct: 546 LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKD 605

Query: 468 K-DDQTPLHCAARIGHTNMVKLLLENNANP---NLATTAGHTPLHIAAREGHVETVLALL 523
               +TPLH +   GHT  ++LLLE   NP   ++    G TPL +A   GH++ V  LL
Sbjct: 606 NVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLL 665

Query: 524 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD 583
           EKEA+   +   G T LH     G     ++LLE++         G TPLH A    +  
Sbjct: 666 EKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHAT 725

Query: 584 IVKLLLPRGGSPHSPAWN---GYTPLHIAA---KQNQVEVA---RSLLQYGGSANAESVQ 634
            +  LL    S     +    GYTPLH A     +N +EV    +   ++ G+       
Sbjct: 726 WLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNP------ 779

Query: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLG--NKSGLTPLHLVAQEGHVPVADVLIKHGV 692
             TPLH A    H    +LLL    +  +   +  G TPL   A   HV    +L++H  
Sbjct: 780 -FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSA 838

Query: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQH-QADVNAKTKLGYSPLHQAAQQGHTDIVT 751
            V+A    G T L +A+  G    V  L+   QAD+  K K   +PLH A  +GH     
Sbjct: 839 PVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCAL 898

Query: 752 LLL 754
           L+L
Sbjct: 899 LIL 901



 Score =  300 bits (768), Expect = 9e-81
 Identities = 227/765 (29%), Positives = 350/765 (45%), Gaps = 42/765 (5%)

Query: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
           L+HK   + T   +  T LH+AA  G  E++  L+  GA VNA+     TPL+ A     
Sbjct: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61

Query: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQ----QGHENVVAHLINYGTKGKVRLPALHI 179
            E V+ L+++ A+ N   ++  TPL VA      +  E ++  L +     +    ALH 
Sbjct: 62  EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHH 121

Query: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
           AA N       +LL    N +   K     LH AA+  +L+V  LL+N GA V    + G
Sbjct: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKG 181

Query: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
            TPLH A+  G + +V+ LL+ G +I+       T LH A  NG   +   L+D+GA + 
Sbjct: 182 YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVN 241

Query: 300 AKTKNGLSPIHMAAQGDH-LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
               NG +P+H AA   H   C+ LL+   A+++  + D  +PLH+ A  G    ++ L+
Sbjct: 242 QPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLI 301

Query: 359 DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLP 418
             G + +    +G TPLH+A +  H  ++  L  +GA         + PLH+A+   H  
Sbjct: 302 QNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSD 361

Query: 419 IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 478
             + LL  G   +  +    T LH AA  G+ E  K L  + A  + K K  +TPLH AA
Sbjct: 362 CCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAA 421

Query: 479 RIGHTNMVKLLLENNANPNLATTAGHTPLHIAARE--GHVETVLA--------------- 521
              H + ++ L+   AN N     G T LH AA       +T+L                
Sbjct: 422 ANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERAREL 481

Query: 522 -----------LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 570
                      LL+ +A+ +   K+G+  +H AA YG  +  ELLLER         +G 
Sbjct: 482 KEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGA 541

Query: 571 T--PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628
           T  PLH+A ++ +   +++LL            G T L +AA +   E   +L+  G S 
Sbjct: 542 TKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI 601

Query: 629 NA-ESVQGVTPLHLAAQEGHAEMVALLLSKQANG---NLGNKSGLTPLHLVAQEGHVPVA 684
              ++V   TPLH +   GH   + LLL    N    ++ +  G TPL L    GH+   
Sbjct: 602 FVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAV 661

Query: 685 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ 744
            +L++    VD    +G T LH     G+ + V+ LL+ +  +  K   G +PLH AA +
Sbjct: 662 SLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAAR 721

Query: 745 GHTDIVTLLLKNGASPNEV---SSDGTTPLAIAKRLGYISVTDVL 786
           GH   ++ LL+   S  +     + G TPL  A   G  +  +VL
Sbjct: 722 GHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVL 766



 Score =  262 bits (670), Expect = 2e-69
 Identities = 190/644 (29%), Positives = 295/644 (45%), Gaps = 36/644 (5%)

Query: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
           +L+    + + L     TPLH+AA   +  + +LL+  GA VN      +TPLH A    
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60

Query: 251 NVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIH 310
           +   V++L+   A +  + K+  TPLH AA N  V+ +E+++   + +    + G + +H
Sbjct: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120

Query: 311 MAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370
            AA   H++ V LLL   A I+         LH AA+ GH  V  +L++ GA+   +   
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180

Query: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
           G+TPLH A     + V++ LL  G  ID +   G T LH+A + G   +V  L+  GA+ 
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240

Query: 431 NVSNVKVETPLHMAARAGHTEVA-KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489
           N  N    TPLH AA + H  +  + L+ N A VN ++KD ++PLH  A  G     + L
Sbjct: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300

Query: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549
           ++N    +     G+TPLH+AAR GH   +  L    A  A        PLH+AA     
Sbjct: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHS 360

Query: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 609
                LL      +   K G T LH A    N++ +KLL   G   H     G TPLH A
Sbjct: 361 DCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420

Query: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE---------GHAE----------- 649
           A         +L+  G + N     G T LH AA           G+A            
Sbjct: 421 AANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARE 480

Query: 650 --------MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK--HGVMVDATTR 699
                    +  LL   AN ++ +K G   +H  A  GH    ++L++  +    ++ + 
Sbjct: 481 LKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSG 540

Query: 700 MGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGAS 759
              +PLH+A++ G+ + ++ LLQ   D++ + + G + L  AA +GHT+ V  L+  GAS
Sbjct: 541 ATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGAS 600

Query: 760 ---PNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 800
               + V+    TPL  +   G+     +L  + D    V V D
Sbjct: 601 IFVKDNVTK--RTPLHASVINGHTLCLRLLLEIADNPEAVDVKD 642



 Score =  188 bits (478), Expect = 4e-47
 Identities = 164/606 (27%), Positives = 255/606 (42%), Gaps = 82/606 (13%)

Query: 9   EADAATSFLRAARSGNLDKALDHLR-NGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
           + D  T    AAR G+ +  ++ LR +G D   C  + +  LHLA+   H     +LL  
Sbjct: 311 DKDGNTPLHVAARYGH-ELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSS 369

Query: 68  EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
              ++T  K G T LH AA  G  E ++ L + GA+ + + + G TPL+ AA   H   +
Sbjct: 370 GFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCI 429

Query: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187
           + L+  GAN N   + G T L  A     +     L N     +  L         + T 
Sbjct: 430 ETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSE-ELERARELKEKEATL 488

Query: 188 TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS---------------- 231
               LLQND NP +  K G+  +H AA Y +    +LLL R  S                
Sbjct: 489 CLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHL 548

Query: 232 -------------------VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-D 271
                              ++   + G T L +A+ +G+   V  L++ GA I  K    
Sbjct: 549 AAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVT 608

Query: 272 ELTPLHCAARNGHVRISEILL---DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328
           + TPLH +  NGH     +LL   D+   +  K   G +P+ +A    H+D V LLL+ +
Sbjct: 609 KRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKE 668

Query: 329 AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVME 388
           A +D + +   T LH     GH    ++LL++      +   G TPLH A  + H   + 
Sbjct: 669 ANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLS 728

Query: 389 LLLKTGASIDAVT---ESGLTPLHVASFMGHLPIVKNLLQR------------------- 426
            LL+   S +        G TPLH A + G+   ++ LL++                   
Sbjct: 729 ELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAII 788

Query: 427 ---------------GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQ 471
                           +  +  + K  TPL  AA A H E  + LL++ A VNA     +
Sbjct: 789 NDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGK 848

Query: 472 TPLHCAARIGHTNMVKLLLENNANPNLATTAG--HTPLHIAAREGHVETVLALLEKEASQ 529
           T L  AA  G    V +L+ N+A  +L       +TPLH+A  +GH +  L +L+K   +
Sbjct: 849 TALMMAAENGQAGAVDILV-NSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDE 907

Query: 530 ACMTKK 535
           + + +K
Sbjct: 908 SLINEK 913



 Score = 95.5 bits (236), Expect = 4e-19
 Identities = 78/296 (26%), Positives = 127/296 (42%), Gaps = 32/296 (10%)

Query: 2   PYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMV 61
           P +V  ++A   T  + A   G++D     L    +++T +  G   LH     GH + V
Sbjct: 635 PEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECV 694

Query: 62  VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN---AQSQKGFTPLYMA 118
             LL +E+ +     +G T LH AA  G    + EL+    +      +  +G+TPL+ A
Sbjct: 695 QMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWA 754

Query: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH 178
               +   ++ LLE    +     + FTPL  A+   H N  + L+         + +  
Sbjct: 755 CYNGNENCIEVLLEQKCFRKF-IGNPFTPLHCAIINDHGNCASLLLG-------AIDSSI 806

Query: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
           ++ R+D                     G TPL  AA  +++   QLLL   A VN    +
Sbjct: 807 VSCRDD--------------------KGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNS 846

Query: 239 GITPLHIASRRGNVIMVRLLLDRG-AQIETKTKDELTPLHCAARNGHVRISEILLD 293
           G T L +A+  G    V +L++   A +  K KD  TPLH A   GH + + ++LD
Sbjct: 847 GKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILD 902


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  315 bits (808), Expect = 2e-85
 Identities = 206/601 (34%), Positives = 312/601 (51%), Gaps = 14/601 (2%)

Query: 182  RNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGIT 241
            R D  RT   LL N  + +     G T L  AA+  +L+V  LL++RGA +     +G T
Sbjct: 524  REDSIRT---LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHT 580

Query: 242  PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301
            PL +A+R+G+  +V  L+  GA I    +D  T L  AA  GH  +   LL  G  +   
Sbjct: 581  PLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCA 640

Query: 302  TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG 361
              +  + +  AA G H D V  LLQ+ AE++    +  T L  AA+ GH  + + LLD G
Sbjct: 641  DADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 700

Query: 362  AKPNSRALNGFTPLHIAC-----KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416
            A+ N   ++G T L +A       K H  V+ LL+  GA +D   + G+TPL VA++ GH
Sbjct: 701  AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGH 760

Query: 417  LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 476
            + +V  LL+ GA  + ++    TPL  AA  GH  V   LL   A V++   + +T L  
Sbjct: 761  VDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSI 820

Query: 477  AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
            A+  G+  +V+ LL+   + N    AG TPLH+AA EGH     AL+E+ A    +   G
Sbjct: 821  ASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880

Query: 537  FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
              P  +A++ G     ++LLE  ++ +  G +G   L VA    + DIV+LL   G   +
Sbjct: 881  RIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVN 940

Query: 597  SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656
                +G   L+I A +NQ+ +A   L+ G +  A   +G T LH++  +GH EMV +L++
Sbjct: 941  CKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIA 1000

Query: 657  KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716
              A+ N  +    + L   A +GHV V  +LI+HG +VD T   G T L +A+  G+I +
Sbjct: 1001 YHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDV 1060

Query: 717  VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK------NGASPNEVSSDGTTP 770
            V+ LL+H AD N   + G + +  AA+ GH+ I+ LL K      NG SP+ V +    P
Sbjct: 1061 VQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKP 1120

Query: 771  L 771
            L
Sbjct: 1121 L 1121



 Score =  282 bits (722), Expect = 2e-75
 Identities = 206/686 (30%), Positives = 327/686 (47%), Gaps = 42/686 (6%)

Query: 90   QDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 149
            + EV++ LV  GA+VN++  +    +  A +    + ++ LL+NGA+ N    +G T LA
Sbjct: 493  EQEVLQLLVKAGAHVNSEDDRTSCIVRQALERE--DSIRTLLDNGASVNQCDSNGRTLLA 550

Query: 150  VALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 209
             A   G  +VV  L++ G                              + ++    G TP
Sbjct: 551  NAAYSGSLDVVNLLVSRGA-----------------------------DLEIEDAHGHTP 581

Query: 210  LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 269
            L +AA   +  V   L+  GA++N T Q+G T L  A+  G+  +V  LL  G +++   
Sbjct: 582  LTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCAD 641

Query: 270  KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 329
             D  T L  AA  GH  I   LL HGA +      G + +  AA   H + V  LL + A
Sbjct: 642  ADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGA 701

Query: 330  EIDDITLDHLTPLHVAAHC-----GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHV 384
            E++   +D  T L VAA C     GH  V  +L+D+GA+ +    +G TPL +A  + HV
Sbjct: 702  EVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHV 761

Query: 385  RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
             V++LLL+ GA +D    +G TPL  A+ MGH  +V  LL  GA+ +  + +  T L +A
Sbjct: 762  DVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIA 821

Query: 445  ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH 504
            +  G+ EV + LL      N +     TPLH AA  GH  + + L+E  A  N     G 
Sbjct: 822  SAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGR 881

Query: 505  TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564
             P  +A++EGH + V  LLE +++       G   L VAA  G   + ELL    A  N 
Sbjct: 882  IPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNC 941

Query: 565  AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624
               +G   L++    N L + +  L  G +  +    G T LH++  Q  +E+ + L+ Y
Sbjct: 942  KDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAY 1001

Query: 625  GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
                NA   +  + L  AA +GH ++V LL+   A  +     G T L + AQEGH+ V 
Sbjct: 1002 HADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVV 1061

Query: 685  DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ 744
             VL++HG   +   + G T + VA+  G+ +++K L ++ A  ++      SP+H   Q+
Sbjct: 1062 QVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA--SSLNGCSPSPVHTMEQK 1119

Query: 745  G----HTDIVTLLLKNGASPNEVSSD 766
                  + + +L +K+ +S +    D
Sbjct: 1120 PLQSLSSKVQSLTIKSNSSGSTGGGD 1145



 Score =  281 bits (719), Expect = 4e-75
 Identities = 184/568 (32%), Positives = 280/568 (49%), Gaps = 5/568 (0%)

Query: 225  LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 284
            LL+ GASVN    NG T L  A+  G++ +V LL+ RGA +E +     TPL  AAR GH
Sbjct: 531  LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGH 590

Query: 285  VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHV 344
             ++   L+  GA I    ++G + +  AA G H + V  LL    ++D    D  T L  
Sbjct: 591  TKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRA 650

Query: 345  AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404
            AA  GH  +   LL  GA+ N     G T L  A    H  ++E LL  GA ++     G
Sbjct: 651  AAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDG 710

Query: 405  LTPLHVASFM-----GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 459
             T L VA+       GH  +V  L+ RGA  +  +    TPL +AA  GH +V   LL+ 
Sbjct: 711  RTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEG 770

Query: 460  KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519
             A V+    + +TPL  AA +GH ++V  LL   A  +   + G T L IA+ +G+VE V
Sbjct: 771  GADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVV 830

Query: 520  LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHH 579
              LL++   +      G+TPLH+AA  G   + E L+E+ A  N    +G  P  +A   
Sbjct: 831  RTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQE 890

Query: 580  NNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPL 639
             + D V++LL    +     ++G   L +AA +   ++   L  +G   N +   G   L
Sbjct: 891  GHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTL 950

Query: 640  HLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTR 699
            ++ A E    M    L   AN    +  G T LH+   +GH+ +  VLI +   V+A   
Sbjct: 951  YILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADN 1010

Query: 700  MGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGAS 759
               + L  A+  G++K+V+ L++H A V+     G + L  AAQ+GH D+V +LL++GA 
Sbjct: 1011 EKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGAD 1070

Query: 760  PNEVSSDGTTPLAIAKRLGYISVTDVLK 787
            PN     G T + +A + G+  +  +L+
Sbjct: 1071 PNHADQFGRTAMRVAAKNGHSQIIKLLE 1098



 Score =  270 bits (690), Expect = 1e-71
 Identities = 185/570 (32%), Positives = 288/570 (50%), Gaps = 11/570 (1%)

Query: 9    EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
            +A   T    AAR G+       +  G +IN  +Q+G   L  A+  GH ++V  LL+  
Sbjct: 575  DAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAG 634

Query: 69   IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
            + ++       TAL  AA  G +++V  L+ +GA VN    +G T L  AA   H E+V+
Sbjct: 635  VKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVE 694

Query: 129  FLLENGANQNVATEDGFTPLAVAL-----QQGHENVVAHLINYGTK----GKVRLPALHI 179
             LL++GA  N    DG T L+VA       +GH +VV+ LI+ G +     K  +  L +
Sbjct: 695  HLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLV 754

Query: 180  AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
            AA         +LL+   + D     G TPL  AA   + +V   LL  GA+V+     G
Sbjct: 755  AAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEG 814

Query: 240  ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
             T L IAS +GNV +VR LLDRG     +     TPLH AA  GH  I E L++ GA   
Sbjct: 815  RTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTN 874

Query: 300  AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
                +G  P  +A+Q  H DCV++LL+  + ID    D    L VAA  GH  + ++L  
Sbjct: 875  EIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFS 934

Query: 360  KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
             GA  N +  +G   L+I   +N + + E  L+ GA+++A    G T LHV+ + GH+ +
Sbjct: 935  HGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEM 994

Query: 420  VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
            V+ L+   A  N ++ +  + L  AA  GH +V + L+++ A V+       T L  AA+
Sbjct: 995  VQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQ 1054

Query: 480  IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
             GH ++V++LLE+ A+PN A   G T + +AA+ GH + ++ LLEK  + + +     +P
Sbjct: 1055 EGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQ-IIKLLEKYGASS-LNGCSPSP 1112

Query: 540  LHVAAKYGKVRVAELLLERDAHPNAAGKNG 569
            +H   +     ++  +       N++G  G
Sbjct: 1113 VHTMEQKPLQSLSSKVQSLTIKSNSSGSTG 1142



 Score =  156 bits (394), Expect = 2e-37
 Identities = 131/456 (28%), Positives = 197/456 (43%), Gaps = 77/456 (16%)

Query: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA---GHTEVAKYLLQNKA 461
           LTPL    F  HL I  NL    A   +  +   TP+  +         EV + L++  A
Sbjct: 447 LTPLEAQEFALHL-INSNLQLETAELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGA 505

Query: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521
            VN++  DD+T       +   + ++ LL+N A+ N   + G T L  AA  G ++ V  
Sbjct: 506 HVNSE--DDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNL 563

Query: 522 LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN 581
           L+ + A        G TPL +AA+ G  +V   L+   A+ N   ++G T L  A    +
Sbjct: 564 LVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGH 623

Query: 582 LDIVKLLLPRG-----------GSPHSPAWNGY----------------------TPLHI 608
            ++V  LL  G            +  + AW G+                      T L  
Sbjct: 624 TEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIA 683

Query: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA-----AQEGHAEMVALLLSKQANGNL 663
           AA     E+   LL +G   N E V G T L +A     A +GHA +V+LL+ + A  + 
Sbjct: 684 AAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDH 743

Query: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP------------------- 704
            +K G+TPL + A EGHV V D+L++ G  VD T   G TP                   
Sbjct: 744 CDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFW 803

Query: 705 --------------LHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
                         L +AS  GN+++V+ LL    D N +   G++PLH AA +GH  I 
Sbjct: 804 GAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLIC 863

Query: 751 TLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
             L++ GA  NE+ +DG  P  +A + G+     +L
Sbjct: 864 EALIEQGARTNEIDNDGRIPFILASQEGHYDCVQIL 899



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 54/163 (33%), Positives = 86/163 (52%)

Query: 5    VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
            V  ++AD   +    A    L  A   L NG ++   +  G   LH++  +GH++MV  L
Sbjct: 939  VNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL 998

Query: 65   LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
            +     +     +  +AL  AA  G  +VV+ L+ +GA V+    +G T L +AAQE H+
Sbjct: 999  IAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHI 1058

Query: 125  EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
            +VV+ LLE+GA+ N A + G T + VA + GH  ++  L  YG
Sbjct: 1059 DVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYG 1101


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
          Length = 2352

 Score =  305 bits (781), Expect = 3e-82
 Identities = 290/994 (29%), Positives = 433/994 (43%), Gaps = 110/994 (11%)

Query: 14   TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
            T  + AA  G++      L +  D+N  +  G   L  A   G+V +V  LL     +E 
Sbjct: 303  TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362

Query: 74   TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132
              + G+T L  A  AG  EV R L+  GA +N  S +   + L +A  + HLE+V+FLLE
Sbjct: 363  HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422

Query: 133  NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------LHIAARNDDT 186
             GA+Q   T++  T L  A   GH  V   L++ G   +V +PA      L +AA     
Sbjct: 423  AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPLTLAACGGHV 480

Query: 187  RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHI 245
              AA+L++   + + ++  G+TPL  AA   +  +  LLL +GA++N  T +   T L +
Sbjct: 481  ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540

Query: 246  ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
            A   G + +   L+  GA IE       TPL  AA+ GH+ + + LL  GA + A T  G
Sbjct: 541  ACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATG 597

Query: 306  LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
             + +  A +  H D   +LLQ  A+++  +    TPL  AA  GH    + L+ KGA  N
Sbjct: 598  DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVN 657

Query: 366  -SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
             + A N  T L +AC   H+ V+ELLL  GA      + G T L  A+  GH  +V  LL
Sbjct: 658  RTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717

Query: 425  QRG----ASPNVSNVKVETPLHMAARAGHTEV--------------------AKYLLQNK 460
                   ++P     ++  P H   RA    V                        ++NK
Sbjct: 718  DYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNK 777

Query: 461  AKVNAKAKDDQTPLH-CAARIGH----------TNMVKLLLENNANPNLATTAGH-TPLH 508
            A     +    TP H  AA I            +    L +    + +  T + H T L 
Sbjct: 778  AVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALT 837

Query: 509  IAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 568
            +A   GH E V  LLE+ AS     KKGFTPL +AA  G V V E+LL+  A   A  + 
Sbjct: 838  LACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSER 897

Query: 569  GL-TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 627
               TPL +A      ++V+LLL RG +      + YTPL +AA    V + + LL  G  
Sbjct: 898  TKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAE 957

Query: 628  ANAE--SVQGVTPLHLAAQEGH----------------------------------AEMV 651
             N+   S  G++PL LAA  GH                                   E+V
Sbjct: 958  INSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVV 1017

Query: 652  ALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA--TTRMGYTPLHVAS 709
            +LLL ++AN     K+GLTPL   A  G+  V  VL+  G  V+A        T L +A+
Sbjct: 1018 SLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAA 1077

Query: 710  HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769
              G+ K  + L+   A ++ + K G +PL  AA  GH D+V LL++ GA  +   +   T
Sbjct: 1078 DKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKIT 1137

Query: 770  PLAIAKRLGYISVTDVL-KVVTDETS-------FVLVSDKHRMS----FPETVDEILDVS 817
            PL  A R G++ V   L K V    S          ++DK  +       E++ +  D  
Sbjct: 1138 PLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQ 1197

Query: 818  EDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVES---------PAIPRIPCAMPE 868
              E  +  S   E  D   + EE   L    K ++  E            +  I     E
Sbjct: 1198 AAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKE 1257

Query: 869  TVVIRSEEQEQASKEYDEDSLIPSSPATETSDNI 902
               +++ ++++  K  DE  ++   P+  T+  I
Sbjct: 1258 NFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTI 1291



 Score =  293 bits (750), Expect = 1e-78
 Identities = 265/859 (30%), Positives = 406/859 (47%), Gaps = 67/859 (7%)

Query: 15   SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
            S   A   G+++     L  G  +N   + G + L LA   G+ ++   LL     +E  
Sbjct: 237  SLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 296

Query: 75   TKKGN-TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
              KG+ T L  AA  G  ++V+ L+ + A+VNAQS  G T L  A    +++VVK LLE+
Sbjct: 297  GIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES 356

Query: 134  GANQNVATEDGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRT 188
            GA+     E+G TPL  A   GH  V   L+  G        + +  AL +A        
Sbjct: 357  GASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEM 416

Query: 189  AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248
               LL+   + +  +    T L  A    ++ VA+LLL+ GA VN    +  +PL +A+ 
Sbjct: 417  VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 476

Query: 249  RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-S 307
             G+V +  LL++RGA +E    +  TPL  AAR GH  +  +LL  GA I A+T+    +
Sbjct: 477  GGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQET 536

Query: 308  PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367
             + +A  G  L+    L++  A   DI L   TPL  AA  GH  + K LL  GA  ++ 
Sbjct: 537  ALTLACCGGFLEVADFLIKAGA---DIELGCSTPLMEAAQEGHLELVKYLLAAGANVHAT 593

Query: 368  ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427
               G T L  AC+  H  V ++LL+ GA ++  +E G TPL  A+  GH+  V+ L+ +G
Sbjct: 594  TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKG 653

Query: 428  ASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486
            A+ N +    + T L +A   GH  V + LL + A    + KD  T L  AA+ GHT++V
Sbjct: 654  ANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVV 713

Query: 487  KLLLENNAN------PNLA--TTAGH------------TPLHIAARE-----GHVETVLA 521
              LL+   N      P++   T   H             P+ +  +E      +V T L 
Sbjct: 714  CYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLP 773

Query: 522  LLEKEASQACMTKKGFTPLH-VAAKYGK---------VRVAELL-----LERDAHPNAAG 566
            +  K  S         TP H +AA   +         +  + +L     ++ DA   +  
Sbjct: 774  IRNKAVSGRASAMSN-TPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTES-- 830

Query: 567  KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626
             N  T L +A    + ++V+ LL RG S       G+TPL +AA    V V   LL  G 
Sbjct: 831  -NHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGA 889

Query: 627  SANAESVQGV-TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVAD 685
               A+S +   TPL LA   G  E+V LLL++ AN    N S  TPL L A  G+V +  
Sbjct: 890  DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 949

Query: 686  VLIKHGVMVDATT--RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG-YSPLHQAA 742
            +L+  G  +++ T  ++G +PL +A+  G+   VK LL   +D+NA+ +    + L  A 
Sbjct: 950  ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1009

Query: 743  QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKH 802
             QG T++V+LLL   A+    +  G TPL  A   GY    +V +V+ D+      +D +
Sbjct: 1010 FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGY---AEVGRVLLDKG-----ADVN 1061

Query: 803  RMSFPETVDEILDVSEDEG 821
                P + D  L ++ D+G
Sbjct: 1062 APPVPSSRDTALTIAADKG 1080



 Score =  282 bits (721), Expect = 2e-75
 Identities = 257/851 (30%), Positives = 383/851 (45%), Gaps = 115/851 (13%)

Query: 17   LRAARSGNLDKALDHLRNGVDINTCN--QNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
            L ++ S  LD+A   L      +T N  Q+    L  A  EG V  V +LL +   +   
Sbjct: 204  LTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEH 263

Query: 75   TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG-FTPLYMAAQENHLEVVKFLLEN 133
            T++G + L +A  AG  E+ + L+   ANV  +  KG  TPL  AA   H+++VK LL +
Sbjct: 264  TEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAH 323

Query: 134  GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLL 193
             A+ N  +  G T L  A   G+ +VV                              VLL
Sbjct: 324  KADVNAQSSTGNTALTYACAGGYVDVV-----------------------------KVLL 354

Query: 194  QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI--TPLHIASRRGN 251
            ++  + +  ++ G TPL  A    ++ VA+LLL  GA +N T  N    + L +A  +G+
Sbjct: 355  ESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN-THSNEFKESALTLACYKGH 413

Query: 252  VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 311
            + MVR LL+ GA  E KT +  T L  A  +GHV ++ +LLD GA +     +  SP+ +
Sbjct: 414  LEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 473

Query: 312  AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA-LN 370
            AA G H++   LL++  A ++++  +  TPL  AA  GH  +  +LL +GA  N++    
Sbjct: 474  AACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEET 533

Query: 371  GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
              T L +AC    + V + L+K GA I+       TPL  A+  GHL +VK LL  GA+ 
Sbjct: 534  QETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANV 590

Query: 431  NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490
            + +    +T L  A   GHT+VA  LLQ  A +  +++  +TPL  AAR GH   V+ L+
Sbjct: 591  HATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLI 650

Query: 491  ENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549
               AN N  T    HT L +A   GH+  V  LL   A      K G T L  AAK G  
Sbjct: 651  SKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 710

Query: 550  RVAELLLERDAHPNAAGKNGLTPLHVAVHHNN------LDIVKLLLPRGGSPHSPAWNGY 603
             V   LL+   +  +A    +T L    H  N      +  + +++P    P  P  N  
Sbjct: 711  SVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVP-PQEPDKPPANVA 769

Query: 604  T--PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTP----------------------- 638
            T  P+   A   +     +   +  +A+    Q  TP                       
Sbjct: 770  TTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTE 829

Query: 639  ------LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692
                  L LA   GH E+V  LL + A+    +K G TPL L A  GHV V ++L+ +G 
Sbjct: 830  SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGA 889

Query: 693  MVDATTR----------------------------------MGYTPLHVASHYGNIKLVK 718
             ++A +                                     YTPL +A+  G + ++K
Sbjct: 890  DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 949

Query: 719  FLLQHQADVNAKT--KLGYSPLHQAAQQGHTDIVTLLLKNGASPN-EVSSDGTTPLAIAK 775
             LL   A++N++T  KLG SPL  AA  GHT  V LLL  G+  N ++ ++  T L +A 
Sbjct: 950  ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1009

Query: 776  RLGYISVTDVL 786
              G   V  +L
Sbjct: 1010 FQGRTEVVSLL 1020



 Score =  225 bits (574), Expect = 3e-58
 Identities = 189/604 (31%), Positives = 292/604 (48%), Gaps = 32/604 (5%)

Query: 9    EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
            E   +T  + AA+ G+L+     L  G +++     G   L  A + GH  +   LL   
Sbjct: 561  ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAG 620

Query: 69   IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVV 127
              LE  ++ G T L  AA AG    V+ L++ GANVN   +    T L +A    HL VV
Sbjct: 621  ADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVV 680

Query: 128  KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA----ARN 183
            + LL +GA+     +DG T L  A + GH +VV +L++Y     +  P   +       +
Sbjct: 681  ELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDY-PNNLLSAPPPDVTQLTPPSH 739

Query: 184  DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI--- 240
            D  R   V +Q  P      +    P ++A      N A  +  R ++++ TP + I   
Sbjct: 740  DLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKA--VSGRASAMSNTPTHSIAAS 797

Query: 241  -------TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
                   TP  I S    ++ +   +D  AQ E+     LT L CA   GH  + + LL+
Sbjct: 798  ISQPQTPTPSPIISPSA-MLPIYPAIDIDAQTESNHDTALT-LACA--GGHEELVQTLLE 853

Query: 294  HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID---DITLDHLTPLHVAAHCGH 350
             GA I+ + K G +P+ +AA   H+  V +LL   A+I+   + T D  TPL +A   G 
Sbjct: 854  RGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD--TPLSLACSGGR 911

Query: 351  HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTES--GLTPL 408
              V ++LL +GA    R ++ +TPL +A    +V ++++LL  GA I++ T S  G++PL
Sbjct: 912  QEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPL 971

Query: 409  HVASFMGHLPIVKNLLQRGASPNVS-NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
             +A+  GH   VK LL  G+  N        T L +A   G TEV   LL  KA V  +A
Sbjct: 972  MLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA 1031

Query: 468  KDDQTPLHCAARIGHTNMVKLLLENNANPNL--ATTAGHTPLHIAAREGHVETVLALLEK 525
            K   TPL  AA  G+  + ++LL+  A+ N     ++  T L IAA +GH +    L+ +
Sbjct: 1032 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGR 1091

Query: 526  EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIV 585
             A      KKG TPL +AA  G + V +LL++  A  +AA    +TPL  A    ++ +V
Sbjct: 1092 GAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVV 1151

Query: 586  KLLL 589
            + L+
Sbjct: 1152 RYLV 1155



 Score = 31.2 bits (69), Expect = 9.8
 Identities = 20/65 (30%), Positives = 31/65 (47%), Gaps = 1/65 (1%)

Query: 5    VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
            +  R     T    AA  G+LD     ++ G D++  +   +  L  A ++GHVK VV  
Sbjct: 1095 IDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVK-VVRY 1153

Query: 65   LHKEI 69
            L KE+
Sbjct: 1154 LVKEV 1158


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score =  297 bits (760), Expect = 7e-80
 Identities = 260/831 (31%), Positives = 366/831 (44%), Gaps = 92/831 (11%)

Query: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
           AA  G+L+     +  G D+   ++ G   LH A+  G +++V  LL     ++     G
Sbjct: 180 AAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFG 239

Query: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA-QENHLEVVKFLLENGANQ 137
           NTALHIA   GQD V  ELVN GANVN  + KGFTPL++AA   N    ++ L+ NGA+ 
Sbjct: 240 NTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADV 299

Query: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLL 193
           N  +++G +PL +A   G       LI  G++     K     LH+AAR       + L+
Sbjct: 300 NYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLM 359

Query: 194 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA--------------SVNF---TP 236
            N  +          PLH+A  +   +  + LL+ G               S  F   TP
Sbjct: 360 TNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTP 419

Query: 237 QN-GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
            N G T LH A+  GNV  + LLL  GA +  + K   TPLH AA NG  + +  L+  G
Sbjct: 420 DNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAG 479

Query: 296 APIQAKTKNGLSPIHMAAQGDHLDCVR--LLLQYDAEIDDITLDHLTPLHVAAHCGHHRV 353
           A +      G SP+H AA  D            +DAE D+       PL  +        
Sbjct: 480 AGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDE-------PLKESRRKEAFFC 532

Query: 354 AKVLLDKGAKPNSRALNGFT-----------------------------------PLHIA 378
            + LLD GA P+ R   G+T                                   PLH+A
Sbjct: 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLA 592

Query: 379 CKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE 438
               H   ++ L +T  ++D     G T L +A+  G    V+ L   GAS  +   K +
Sbjct: 593 AYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRK 652

Query: 439 -TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD---QTPLHCAARIGHTNMVKLLLENNA 494
            TPLH AA +GHT+    L+ +  + +     D   QTPL  A   GH + V LLLE  +
Sbjct: 653 WTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGS 712

Query: 495 NPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAEL 554
             + A   G T LH  A  G  + + ALL+ +A   C   KG TP+H+A+  G   V   
Sbjct: 713 TADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRT 772

Query: 555 LLER--DAHPNAAGKN--GLTPLHVAVHHNNLDIVKLLLPRGGSPHSP----AWNGYTPL 606
           LL+      P  AG +  G +P+H A +  + D ++LLL      HSP      N +TPL
Sbjct: 773 LLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE-----HSPFSYLEGNPFTPL 827

Query: 607 HIAAKQNQVEVARSLLQYGGS--ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
           H A   NQ      LL   G+   N+   +G TPLH AA   +   + +LL  QA  N  
Sbjct: 828 HCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNAT 887

Query: 665 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATT--RMGYTPLHVASHYGNIKLVKFLLQ 722
           + +G T L   A+ G     + L+  G   D T       T LH+A   G+ K    +L 
Sbjct: 888 DHTGRTALMTAAENGQTAAVEFLLYRG-KADLTVLDENKNTALHLACSKGHEKCALMILA 946

Query: 723 HQAD---VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 770
              D   +NA       PLH AA+ G   +V  LL +GA+   V  +G TP
Sbjct: 947 ETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTP 997



 Score =  286 bits (732), Expect = 1e-76
 Identities = 226/744 (30%), Positives = 329/744 (44%), Gaps = 60/744 (8%)

Query: 114 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI----NYGTK 169
           PL  A     +E V+ LL    N NV  ++  TPL  A   G   ++  L+    N   K
Sbjct: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70

Query: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229
             + L  LH AA + + +   +LL +  + +   K   TPLH+AA       A+ L    
Sbjct: 71  DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130

Query: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
           +S+N   ++G + LH A   G++  V LLL++GA +    K E  PLH AA  GH+ + +
Sbjct: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLK 190

Query: 290 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 349
           +L+  GA +  K + G   +H AA    ++ V+ LL+  AEID+      T LH+A + G
Sbjct: 191 LLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLG 250

Query: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIAC-KKNHVRVMELLLKTGASIDAVTESGLTPL 408
              VA  L++ GA  N     GFTPLH+A    N    +ELL+  GA ++  ++ G +PL
Sbjct: 251 QDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPL 310

Query: 409 HVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAK 468
           H+A+  G     + L+Q G+  + ++    TPLH+AAR GH  +   L+ N A    +  
Sbjct: 311 HMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGI 370

Query: 469 DDQTPLHCAARIGHTNMVKLLLENNA------------------NPNLATTAGHTPLHIA 510
            D  PLH A   G ++  + LL +                    + N     G T LH A
Sbjct: 371 HDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAA 430

Query: 511 AREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 570
           A  G+VE +  LL   A      K G TPLH AA  G  + A  L+   A  N A   G 
Sbjct: 431 ASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGC 490

Query: 571 TPLHVAV---------------HHNNLD-------------IVKLLLPRGGSPHSPAWNG 602
           +PLH A                H    D              ++ LL  G  P      G
Sbjct: 491 SPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQG 550

Query: 603 YTPLHIAAKQNQVEVARSLLQ--YGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
           YT +H AA     +    LL+  +    + ES   V+PLHLAA  GH E +  L     N
Sbjct: 551 YTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVN 610

Query: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTR-MGYTPLHVASHYGNIKLVKF 719
            ++ +  G T L L  + G     +VL  HG       R   +TPLH A+  G+   +  
Sbjct: 611 LDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHL 670

Query: 720 LLQ--HQADV-NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKR 776
           L+    +AD+ +     G +PL  A   GH D V LLL+ G++ +     G T L    R
Sbjct: 671 LIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTAL---HR 727

Query: 777 LGYISVTDVLKVVTDETSFVLVSD 800
                  D L  + D  +FVL  D
Sbjct: 728 GAVTGCEDCLAALLDHDAFVLCRD 751



 Score =  285 bits (730), Expect = 2e-76
 Identities = 253/863 (29%), Positives = 371/863 (42%), Gaps = 98/863 (11%)

Query: 14  TSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILE 72
           T   RAA S N +K L  L  +  D+N  ++     LH+A+     K    L      L 
Sbjct: 76  TPLHRAAASRN-EKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLN 134

Query: 73  TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
              + G +ALH A  +G  E V  L+N GA++N   +K   PL+ AA   HLEV+K L+ 
Sbjct: 135 VADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVA 194

Query: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRT 188
            GA+       G+  L  A   G   VV +L+  G +          ALHIA        
Sbjct: 195 RGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAV 254

Query: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA-QLLLNRGASVNFTPQNGITPLHIAS 247
           A  L+    N +  +  GFTPLH+AA   N  +  +LL+N GA VN+  + G +PLH+A+
Sbjct: 255 AIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAA 314

Query: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307
             G     ++L+  G++I+   K   TPLH AAR GH  +   L+ +GA    +  + + 
Sbjct: 315 IHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMF 374

Query: 308 PIHMAAQGDHLDCVRLLLQ----------------YDAEIDDITLDHL--TPLHVAAHCG 349
           P+H+A      DC R LL                   A  D  T D+L  T LH AA  G
Sbjct: 375 PLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGG 434

Query: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLH 409
           +     +LL  GA    R   G TPLH A      +    L+  GA ++     G +PLH
Sbjct: 435 NVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLH 494

Query: 410 VASFMG-------HLP---------------------IVKNLLQRGASPNVSNVKVETPL 441
            A+          H P                      ++ LL  GA P++ + +  T +
Sbjct: 495 YAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAV 554

Query: 442 HMAARAGHTEVAKYLLQNKAKV--NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 499
           H AA  G+ +  + LL+       + ++    +PLH AA  GH   +K L E   N ++ 
Sbjct: 555 HYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVR 614

Query: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACM-TKKGFTPLHVAAKYGKVRVAELLL-- 556
              G T L +A   G  E V  L    AS      K+ +TPLH AA  G      LL+  
Sbjct: 615 DHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDS 674

Query: 557 -ERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615
            ER    +     G TPL +A+ + ++D V LLL +G +  +    G T LH  A     
Sbjct: 675 GERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCE 734

Query: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL----GNKSGLTP 671
           +   +LL +         +G TP+HLA+  GH  ++  LL    + +      + SG +P
Sbjct: 735 DCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSP 794

Query: 672 LHLVAQEGHVPVADVLIKHGVM------------------VDATTRM------------- 700
           +H  +  GH    ++L++H                      D+TT M             
Sbjct: 795 MHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSR 854

Query: 701 ---GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 757
              G TPLH A+   N+  ++ LLQHQA+VNA    G + L  AA+ G T  V  LL  G
Sbjct: 855 DAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRG 914

Query: 758 -ASPNEVSSDGTTPLAIAKRLGY 779
            A    +  +  T L +A   G+
Sbjct: 915 KADLTVLDENKNTALHLACSKGH 937



 Score =  260 bits (664), Expect = 1e-68
 Identities = 208/698 (29%), Positives = 305/698 (43%), Gaps = 86/698 (12%)

Query: 175 PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 234
           P L  A  + D      LL    N +VL +   TPLH AA+  ++ + QLLL  GA+VN 
Sbjct: 10  PPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNA 69

Query: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294
                +TPLH A+   N  ++ LLL   A +  + K   TPLH AA N   + +E L   
Sbjct: 70  KDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPL 129

Query: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354
            + +    ++G S +H A    HL+ V LLL   A ++        PLH AA  GH  V 
Sbjct: 130 LSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVL 189

Query: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414
           K+L+ +GA    +   G+  LH A     + V++ LL+ GA ID     G T LH+A ++
Sbjct: 190 KLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYL 249

Query: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA-KYLLQNKAKVNAKAKDDQTP 473
           G   +   L+  GA+ N  N K  TPLH+AA + +  +  + L+ N A VN ++K+ ++P
Sbjct: 250 GQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSP 309

Query: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
           LH AA  G     ++L++N +  + A   G+TPLH+AAR GH   +  L+   A  A   
Sbjct: 310 LHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRG 369

Query: 534 KKGFTPLHVAAKYGKVRVAELLLE-----------RDAHPNAAGKN-------GLTPLHV 575
                PLH+A  +G       LL             + H  +AG +       G T LH 
Sbjct: 370 IHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHA 429

Query: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
           A    N++ + LLL  G         G TPLH AA     + A +L+  G   N    +G
Sbjct: 430 AASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKG 489

Query: 636 VTPLHLAA-------QEGHAE---------------------MVALLLSKQANGNLGNKS 667
            +PLH AA        E H                        +  LL   A+ +L ++ 
Sbjct: 490 CSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQ 549

Query: 668 GLT-----------------------------------PLHLVAQEGHVPVADVLIKHGV 692
           G T                                   PLHL A  GH      L +  V
Sbjct: 550 GYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLV 609

Query: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK-TKLGYSPLHQAAQQGHTDIVT 751
            +D     G T L +A+  G+ + V+ L  H A    K  K  ++PLH AA  GHTD + 
Sbjct: 610 NLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLH 669

Query: 752 LLLKNGAS---PNEVSSDGTTPLAIAKRLGYISVTDVL 786
           LL+ +G      + + + G TPL +A   G++    +L
Sbjct: 670 LLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLL 707



 Score =  246 bits (627), Expect = 2e-64
 Identities = 201/686 (29%), Positives = 299/686 (43%), Gaps = 54/686 (7%)

Query: 201 VLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 260
           +LS T   PL  A    ++   + LL++  ++N   Q   TPLH A+  G+V +++LLL 
Sbjct: 3   ILSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLM 62

Query: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
            GA +  K    LTPLH AA + + ++  +LL H A + A+ K   +P+H+AA      C
Sbjct: 63  SGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKC 122

Query: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380
              L    + ++       + LH A H GH     +LL+KGA  N        PLH A  
Sbjct: 123 AEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAF 182

Query: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440
             H+ V++LL+  GA +      G   LH A+  G + +VK LL+ GA  +  N    T 
Sbjct: 183 LGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTA 242

Query: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA-RIGHTNMVKLLLENNANPNLA 499
           LH+A   G   VA  L+   A VN       TPLH AA        ++LL+ N A+ N  
Sbjct: 243 LHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQ 302

Query: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 559
           +  G +PLH+AA  G       L++  +   C  K G TPLHVAA+YG   +   L+   
Sbjct: 303 SKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNG 362

Query: 560 AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG---------GSPH---------SPAWN 601
           A     G + + PLH+AV     D  + LL  G          + H         +P   
Sbjct: 363 ADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNL 422

Query: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
           G T LH AA    VE    LL  G         G TPLH AA  G  +    L++  A  
Sbjct: 423 GRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGV 482

Query: 662 NLGNKSGLTPLHLVA-------QEGHVPVA---------------------DVLIKHGVM 693
           N  +  G +PLH  A        E H P +                     + L+ +G  
Sbjct: 483 NEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGAD 542

Query: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV--NAKTKLGYSPLHQAAQQGHTDIVT 751
                R GYT +H A+ YGN + ++ LL+   +   + ++ +  SPLH AA  GH + + 
Sbjct: 543 PSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALK 602

Query: 752 LLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVD 811
            L +   + +     G T L +A   G    T+ ++V+T   +  L+ ++ R   P  + 
Sbjct: 603 TLAETLVNLDVRDHKGRTALFLATERG---STECVEVLTAHGASALIKERKRKWTP--LH 657

Query: 812 EILDVSEDEGEELISFKAERRDSRDV 837
                   +   L+    ER D  DV
Sbjct: 658 AAAASGHTDSLHLLIDSGERADITDV 683



 Score =  197 bits (501), Expect = 8e-50
 Identities = 182/627 (29%), Positives = 269/627 (42%), Gaps = 32/627 (5%)

Query: 22   SGNLDKALDHLRN------GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT 75
            SG L   +  L N      G DINT +  G   LH A+  G+V+ +  LL     L    
Sbjct: 394  SGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRD 453

Query: 76   KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135
            K G T LH AA  G  +    LV  GA VN    KG +PL+ AA  +     +    +  
Sbjct: 454  KFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE---PHTP 510

Query: 136  NQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARNDDTRTAAV 191
            + + A ED   PL  + ++     +  L++ G    +R      A+H AA   + +   +
Sbjct: 511  SSHDAEED--EPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLEL 568

Query: 192  LLQNDPN--PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
            LL+   N   DV S    +PLH+AA+  +    + L     +++     G T L +A+ R
Sbjct: 569  LLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATER 628

Query: 250  GNVIMVRLLLDRGAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQ---AKTKNG 305
            G+   V +L   GA    K  K + TPLH AA +GH     +L+D G            G
Sbjct: 629  GSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYG 688

Query: 306  LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
             +P+ +A    H+DCV LLL+  +  D   L   T LH  A  G       LLD  A   
Sbjct: 689  QTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVL 748

Query: 366  SRALNGFTPLHIACKKNHVRVMELLLKTGASID----AVTESGLTPLHVASFMGHLPIVK 421
             R   G TP+H+A    H  V+  LL+   S D     V  SG +P+H AS+ GH   ++
Sbjct: 749  CRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLE 808

Query: 422  NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK--VNAKAKDDQTPLHCAAR 479
             LL+      +      TPLH A         + LL       VN++    +TPLH AA 
Sbjct: 809  LLLEHSPFSYLEGNPF-TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAF 867

Query: 480  IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK-EASQACMTKKGFT 538
              + + +++LL++ A  N     G T L  AA  G    V  LL + +A    + +   T
Sbjct: 868  ADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNT 927

Query: 539  PLHVAAKYGKVRVAELLLERDAHP---NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
             LH+A   G  + A ++L         NA       PLH+A  +    +V+ LL  G + 
Sbjct: 928  ALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATV 987

Query: 596  HSPAWNGYTPLHIAAKQNQVEVARSLL 622
             +    G+TP    A    V    +L+
Sbjct: 988  LAVDEEGHTPALACAPNKDVADCLALI 1014



 Score = 48.9 bits (115), Expect = 5e-05
 Identities = 35/111 (31%), Positives = 55/111 (49%), Gaps = 6/111 (5%)

Query: 14   TSFLRAARSGNLDKALDHL--RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI-- 69
            T+ + AA +G    A++ L  R   D+   ++N    LHLA  +GH K  + +L +    
Sbjct: 893  TALMTAAENGQT-AAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDL 951

Query: 70   -ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 119
             ++  T       LHIAA  G   VV+ L+++GA V A  ++G TP    A
Sbjct: 952  GLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACA 1002


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score =  296 bits (758), Expect = 1e-79
 Identities = 240/783 (30%), Positives = 356/783 (45%), Gaps = 103/783 (13%)

Query: 89  GQDEVVRELVNYGANVNAQSQKG--FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFT 146
           G  E V+ LV     VN++   G   TPL+ AA     +VV++LL+NGAN     + G  
Sbjct: 35  GDVERVKRLVT-PEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLI 93

Query: 147 PLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPDVL 202
           PL  A   GH  VV  L+ +G     R       LH AA         VLLQ+   P + 
Sbjct: 94  PLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIR 153

Query: 203 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVI-MVRLLLDR 261
           +  G T L +A             +  A    T +     L  ++R GN   M+ LL   
Sbjct: 154 NTDGRTALDLA-------------DPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPL 200

Query: 262 GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV 321
                     + TPLH AA    V+I ++LL HGA + AK K  L P+H A    H +  
Sbjct: 201 NVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVT 260

Query: 322 RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKK 381
            LL+++ A ++ + L   TPLH AA      V  +LL  GA P     +  + + +A   
Sbjct: 261 ELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTP 320

Query: 382 NHVRVMELLLKTGASIDAVTESGLT---------------------PLHVAS---FMGHL 417
                +    K  + + A  E+ +T                      LH A+   +    
Sbjct: 321 QLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRK 380

Query: 418 PIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477
            I + LL++GA+ N    +  TPLH+A+   H +V + +++++AKVNA     QT LH A
Sbjct: 381 QICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRA 440

Query: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPLHI--------------------------AA 511
           A  GH    +LLL    +PN+ +  G T L +                          AA
Sbjct: 441 AYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAA 500

Query: 512 REGHVETVLALLEKEASQACMTKKG--FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569
           + G VETV  L   + S  C   +G   TPLH AA Y +V V E LL+  A  +A  K G
Sbjct: 501 KAGDVETVKKLCTVQ-SVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGG 559

Query: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
           L PLH A  + + ++ +LL+  G   +      +TPLH AA + + E+ + LLQ+G    
Sbjct: 560 LVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPT 619

Query: 630 AESVQGVTPLHLAAQEGHAEMVALL--------------------LSKQANGNLGNKSGL 669
            ++  G TPL L  ++G  ++  LL                    LS   N N  +  G 
Sbjct: 620 KKNRDGNTPLDLV-KDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGR 678

Query: 670 --TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727
             TPLHL A   ++ VA+ L++HG  V+A  + G  PLH A+ YG++ +   L+++ A V
Sbjct: 679 HSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACV 738

Query: 728 NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
           NA  K  ++PLH+AAQ+G T +  LLL +GA P   + +G TPL +      +S  DV  
Sbjct: 739 NATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDL------VSADDVSA 792

Query: 788 VVT 790
           ++T
Sbjct: 793 LLT 795



 Score =  281 bits (718), Expect = 5e-75
 Identities = 236/774 (30%), Positives = 348/774 (44%), Gaps = 87/774 (11%)

Query: 12  AATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELLHKEI 69
           AA     A R+G++++ +  L     +N+ +  G     LH A+  G   +V  LL    
Sbjct: 24  AARELFEACRNGDVER-VKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGA 82

Query: 70  ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129
            ++     G   LH A   G  EVV  L+ +GA+ NA+    +TPL+ AA +  ++V   
Sbjct: 83  NVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIV 142

Query: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 189
           LL++GA   +   DG T L +A      +  A  +  G   K  L  L  A   ++ +  
Sbjct: 143 LLQHGAEPTIRNTDGRTALDLA------DPSAKAVLTGEYKKDEL--LESARSGNEEKMM 194

Query: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
           A+L   + N         TPLH+AA Y  + + QLLL  GA V+   +  + PLH A   
Sbjct: 195 ALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSY 254

Query: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309
           G+  +  LL+  GA +      + TPLH AA    V +  +LL +GA       +  S I
Sbjct: 255 GHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAI 314

Query: 310 HMAAQGDHLDCV------RLLLQYDAEID------DITLD---------HLTPLHVAA-- 346
            +A      + +        LLQ   E D       ++L+         H T LH AA  
Sbjct: 315 DLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAAS 374

Query: 347 -HCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 405
            +    ++ ++LL KGA  N +     TPLH+A +K H  V+E+++K  A ++A+   G 
Sbjct: 375 PYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQ 434

Query: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM---------------------- 443
           T LH A++ GHL   + LL  G  PN+ +++  T L M                      
Sbjct: 435 TSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADR 494

Query: 444 ----AARAGHTEVAKYLLQNKAKVNAKAKD--DQTPLHCAARIGHTNMVKLLLENNANPN 497
               AA+AG  E  K L   ++ VN +  +    TPLH AA     ++V+ LL++ A+ +
Sbjct: 495 QLLEAAKAGDVETVKKLCTVQS-VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVH 553

Query: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557
                G  PLH A   GH E    L++  A         FTPLH AA  GK  + +LLL+
Sbjct: 554 AKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQ 613

Query: 558 RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL--------------LPRGGSPHSP----- 598
             A P    ++G TPL + V   + DI  LL              L R     SP     
Sbjct: 614 HGADPTKKNRDGNTPLDL-VKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNC 672

Query: 599 ---AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
                   TPLH+AA  N +EVA  LLQ+G   NA+   G+ PLH AA  GH ++ ALL+
Sbjct: 673 RDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLI 732

Query: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
              A  N  +K   TPLH  AQ+G   +  +L+ HG       + G TPL + S
Sbjct: 733 KYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVS 786



 Score =  229 bits (583), Expect = 2e-59
 Identities = 204/644 (31%), Positives = 289/644 (44%), Gaps = 81/644 (12%)

Query: 246 ASRRGNVIMV-RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
           A R G+V  V RL+             + TPLH AA  G   + E LL +GA +QA+   
Sbjct: 31  ACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDG 90

Query: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364
           GL P+H A    H + V LLL++ A+ +     + TPLH AA  G   V  VLL  GA+P
Sbjct: 91  GLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEP 150

Query: 365 NSRALNGFTPLHIA-----------CKK----------NHVRVMELLLKTGASIDAVTES 403
             R  +G T L +A            KK          N  ++M LL     +  A    
Sbjct: 151 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGR 210

Query: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463
             TPLH+A+    + IV+ LLQ GA  +  +     PLH A   GH EV + L+++ A V
Sbjct: 211 KSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACV 270

Query: 464 NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT---------------------- 501
           NA      TPLH AA      +  LLL   A+P L                         
Sbjct: 271 NAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEF 330

Query: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA--KYGK-VRVAELLLER 558
            GH+ L  AARE  V  +   L  E       +   T LH AA   Y K  ++ ELLL +
Sbjct: 331 KGHSLLQ-AAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRK 389

Query: 559 DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 618
            A+ N   K  LTPLHVA    + D+V++++      ++    G T LH AA    ++  
Sbjct: 390 GANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTC 449

Query: 619 RSLLQYGGSANAESVQGVTPLHL--------------------------AAQEGHAEMVA 652
           R LL YG   N  S+QG T L +                          AA+ G  E V 
Sbjct: 450 RLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVK 509

Query: 653 LLLSKQANGNLGNKSG--LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASH 710
            L + Q + N  +  G   TPLH  A    V V + L++HG  V A  + G  PLH A  
Sbjct: 510 KLCTVQ-SVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACS 568

Query: 711 YGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 770
           YG+ ++ + L++H A VN      ++PLH+AA +G  +I  LLL++GA P + + DG TP
Sbjct: 569 YGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTP 628

Query: 771 LAIAKRLGYISVTDVLK---VVTDETSFVLVSDKHRMSFPETVD 811
           L + K  G   + D+L+    + D      ++   ++S P+ V+
Sbjct: 629 LDLVKD-GDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVN 671



 Score =  191 bits (486), Expect = 4e-48
 Identities = 173/584 (29%), Positives = 256/584 (43%), Gaps = 92/584 (15%)

Query: 32  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 91
           L++G D++  ++  L  LH A   GH ++   L+     +        T LH AA   + 
Sbjct: 231 LQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRV 290

Query: 92  EVVRELVNYGAN---VNAQSQKGF----TP--------------LYMAAQENH------- 123
           EV   L++YGA+   +N  ++       TP              L  AA+E         
Sbjct: 291 EVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKH 350

Query: 124 --LEVVKF---------------------------LLENGANQNVATEDGFTPLAVALQQ 154
             LE+V F                           LL  GAN N  T++  TPL VA ++
Sbjct: 351 LSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEK 410

Query: 155 GHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPL 210
            H +VV  ++ +  K      +   +LH AA     +T  +LL    +P+++S  GFT L
Sbjct: 411 AHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTAL 470

Query: 211 HIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD-RGAQIETKT 269
            +     N NV QLL   G S+  +  +    L  A++ G+V  V+ L   +        
Sbjct: 471 QMG----NENVQQLL-QEGISLGNSEAD--RQLLEAAKAGDVETVKKLCTVQSVNCRDIE 523

Query: 270 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 329
             + TPLH AA    V + E LL HGA + AK K GL P+H A    H +   LL+++ A
Sbjct: 524 GRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGA 583

Query: 330 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMEL 389
            ++   L   TPLH AA  G + + K+LL  GA P  +  +G TPL +  K     + +L
Sbjct: 584 VVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV-KDGDTDIQDL 642

Query: 390 LLKTGASIDAVTESGL----------------------TPLHVASFMGHLPIVKNLLQRG 427
           L    A +DA  +  L                      TPLH+A+   +L + + LLQ G
Sbjct: 643 LRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHG 702

Query: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487
           A  N  +     PLH AA  GH +VA  L++  A VNA  K   TPLH AA+ G T +  
Sbjct: 703 ADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCA 762

Query: 488 LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC 531
           LLL + A+P L    G TPL + + +     + A +   A  +C
Sbjct: 763 LLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPSC 806



 Score =  129 bits (325), Expect = 2e-29
 Identities = 101/318 (31%), Positives = 150/318 (47%), Gaps = 19/318 (5%)

Query: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG-----LHLASKEGHV 58
           S+G  EAD     L AA++G+++     ++    + + N   + G     LH A+    V
Sbjct: 486 SLGNSEADR--QLLEAAKAGDVET----VKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRV 539

Query: 59  KMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 118
            +V  LL     +    K G   LH A   G  EV   LV +GA VN      FTPL+ A
Sbjct: 540 SVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEA 599

Query: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH 178
           A +   E+ K LL++GA+      DG TPL + ++ G  ++   L     +G   L  L 
Sbjct: 600 AAKGKYEICKLLLQHGADPTKKNRDGNTPLDL-VKDGDTDIQDLL-----RGDAAL--LD 651

Query: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
            A +    R   +   ++ N         TPLH+AA Y NL VA+ LL  GA VN   + 
Sbjct: 652 AAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKG 711

Query: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
           G+ PLH A+  G+V +  LL+   A +    K   TPLH AA+ G  ++  +LL HGA  
Sbjct: 712 GLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP 771

Query: 299 QAKTKNGLSPIHMAAQGD 316
             K + G +P+ + +  D
Sbjct: 772 TLKNQEGQTPLDLVSADD 789



 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 57/152 (37%), Positives = 84/152 (55%), Gaps = 6/152 (3%)

Query: 627 SANAESVQ-GVTPLHLAAQEGHAEMVALLLSKQ---ANGNLGNKSGLTPLHLVAQEGHVP 682
           SA AE+V+     L  A + G  E V  L++ +   +    G KS  TPLH  A  G   
Sbjct: 15  SAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKS--TPLHFAAGFGRKD 72

Query: 683 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742
           V + L+++G  V A    G  PLH A  +G+ ++V  LL+H AD NA+    Y+PLH+AA
Sbjct: 73  VVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAA 132

Query: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
            +G  D+  +LL++GA P   ++DG T L +A
Sbjct: 133 IKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA 164


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score =  294 bits (752), Expect = 6e-79
 Identities = 235/762 (30%), Positives = 348/762 (45%), Gaps = 97/762 (12%)

Query: 94  VRELVNYGANVNAQSQKG--FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151
           V+ LV+  ANVNA+   G   +PL+ AA     +VV+ LL+ GAN +   + G  PL  A
Sbjct: 198 VKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNA 256

Query: 152 LQQGHENVVAHLINYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGF 207
              GH  VV+ L+  G     R       LH AA         VLLQ+  +P++ +  G 
Sbjct: 257 CSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGK 316

Query: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVI-MVRLLLDRGAQIE 266
           + L +A             +  A    T +     L  A+R GN   ++ LL        
Sbjct: 317 SALDLA-------------DPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCH 363

Query: 267 TKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 326
                + TPLH AA    VRI ++LL HGA + AK K GL P+H A    H +   LLL+
Sbjct: 364 ASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLK 423

Query: 327 YDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 386
           + A ++ + L   TPLH AA      V  +LL  GA P     +G + + +A        
Sbjct: 424 HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRER 483

Query: 387 MELLLKTGASIDAVTESGL---------------------TPLHVASFMGH---LPIVKN 422
           +    K  + + A  E+ L                     T LH A    H     + + 
Sbjct: 484 LTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTEL 543

Query: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482
           LL++GA+ N  N    TPLH+AA   H +V + L ++ AK+NA     QT LH AA  GH
Sbjct: 544 LLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGH 603

Query: 483 TNMVKLLLENNANPNLATTAGHTPLHI--------------------------AAREGHV 516
               +LLL   ++P++ +  G T   +                          A++ G +
Sbjct: 604 LQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDL 663

Query: 517 ETVLALLEKEASQACMTKKG--FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH 574
           ETV  L   + +  C   +G   TPLH AA Y +V V E LL   A  +A  K GL PLH
Sbjct: 664 ETVKQLCSSQ-NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLH 722

Query: 575 VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ 634
            A  + + ++ +LL+  G S +      +TPLH AA + + E+ + LL++G     ++  
Sbjct: 723 NACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRD 782

Query: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL----------------------TPL 672
           G TPL L  +EG  ++  LL    A  +   K  L                      TPL
Sbjct: 783 GNTPLDLV-KEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPL 841

Query: 673 HLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTK 732
           HL A   ++ VA+ L++HG  V+A  + G  PLH A+ YG++ +   L+++   VNA  K
Sbjct: 842 HLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDK 901

Query: 733 LGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
             ++PLH+AAQ+G T +  LLL +GA P   + +G TPL +A
Sbjct: 902 WAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 943



 Score =  290 bits (742), Expect = 9e-78
 Identities = 236/774 (30%), Positives = 347/774 (44%), Gaps = 87/774 (11%)

Query: 12  AATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELLHKEI 69
           A    L A R+G++ + +  L +  ++N  +  G     LH A+  G   +V  LL    
Sbjct: 182 ALRELLEACRNGDVSR-VKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGA 240

Query: 70  ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129
            +      G   LH A   G  EVV  L+  GA+ NA+    +TPL+ AA +  ++V   
Sbjct: 241 NVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIV 300

Query: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 189
           LL++GA+ N+   DG + L +A      +  A  +  G   K  L  L  A   ++ +  
Sbjct: 301 LLQHGADPNIRNTDGKSALDLA------DPSAKAVLTGEYKKDEL--LEAARSGNEEKLM 352

Query: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
           A+L   + N         TPLH+AA Y  + + QLLL  GA V+   + G+ PLH A   
Sbjct: 353 ALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSY 412

Query: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309
           G+  +  LLL  GA +      + TPLH AA    V +  +LL HGA       +G S +
Sbjct: 413 GHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAV 472

Query: 310 HMAAQGDHLDCVRL------LLQYDAEID------DITLD---------HLTPLHVAA-- 346
            MA   +  + +        LLQ   E D       + L+         H T LH A   
Sbjct: 473 DMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVAS 532

Query: 347 -HCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 405
            H    +V ++LL KGA  N +  +  TPLH+A ++ H  VME+L K GA ++A+   G 
Sbjct: 533 LHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQ 592

Query: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM---------------------- 443
           T LH A+  GHL   + LL  G+ P++ +++  T   M                      
Sbjct: 593 TALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDY 652

Query: 444 ----AARAGHTEVAKYLLQNKAKVNAKAKDDQ--TPLHCAARIGHTNMVKLLLENNANPN 497
               A++AG  E  K L  ++  VN +  + +  TPLH AA     ++V+ LL + A+ +
Sbjct: 653 RLLEASKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVH 711

Query: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557
                G  PLH A   GH E    L+   AS        FTPLH AA  GK  + +LLL+
Sbjct: 712 AKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLK 771

Query: 558 RDAHPNAAGKNGLTPLHVAVHHNNLDIV----------------------KLLLPRGGSP 595
             A P    ++G TPL + V   + DI                       KL  P   + 
Sbjct: 772 HGADPTKKNRDGNTPLDL-VKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINC 830

Query: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
                   TPLH+AA  N +EVA  LL++G   NA+   G+ PLH AA  GH ++ ALL+
Sbjct: 831 RDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLI 890

Query: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
                 N  +K   TPLH  AQ+G   +  +L+ HG       + G TPL +A+
Sbjct: 891 KYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLAT 944



 Score =  234 bits (596), Expect = 8e-61
 Identities = 199/617 (32%), Positives = 279/617 (45%), Gaps = 78/617 (12%)

Query: 246 ASRRGNVIMVRLLLDRGAQIETKTKD--ELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
           A R G+V  V+ L+D  A +  K     + +PLH AA  G   + E LL  GA + A+  
Sbjct: 189 ACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDD 247

Query: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
            GL P+H A    H + V LLL   A+ +     + TPLH AA  G   V  VLL  GA 
Sbjct: 248 GGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAD 307

Query: 364 PNSRALNGFTPLHIA-----------CKK----------NHVRVMELLLKTGASIDAVTE 402
           PN R  +G + L +A            KK          N  ++M LL     +  A   
Sbjct: 308 PNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDG 367

Query: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK 462
              TPLH+A+    + IV+ LLQ GA  +  +     PLH A   GH EV + LL++ A 
Sbjct: 368 RKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGAC 427

Query: 463 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA------------ 510
           VNA      TPLH AA      +  LLL + A+P L    G + + +A            
Sbjct: 428 VNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYE 487

Query: 511 ---------AREGHVETVLALLEKEASQACMTKKGFTPLH--VAAKYGKVR-VAELLLER 558
                    ARE  +  V   L  E       +   T LH  VA+ + K + V ELLL +
Sbjct: 488 FKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRK 547

Query: 559 DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 618
            A+ N   K+ +TPLHVA    + D++++L   G   ++    G T LH AA    ++  
Sbjct: 548 GANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTC 607

Query: 619 RSLLQYGGSANAESVQGVTPLHL--------------------------AAQEGHAEMVA 652
           R LL YG   +  S+QG T   +                          A++ G  E V 
Sbjct: 608 RLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVK 667

Query: 653 LLLSKQANGNLGNKSGL--TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASH 710
            L S Q N N  +  G   TPLH  A    V V + L+ HG  V A  + G  PLH A  
Sbjct: 668 QLCSSQ-NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACS 726

Query: 711 YGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 770
           YG+ ++ + L++H A VN      ++PLH+AA +G  +I  LLLK+GA P + + DG TP
Sbjct: 727 YGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTP 786

Query: 771 LAIAKRLGYISVTDVLK 787
           L + K  G   + D+L+
Sbjct: 787 LDLVKE-GDTDIQDLLR 802



 Score =  191 bits (485), Expect = 6e-48
 Identities = 170/588 (28%), Positives = 250/588 (42%), Gaps = 100/588 (17%)

Query: 32  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 91
           L++G D++  ++ GL  LH A   GH ++   LL     +        T LH AA   + 
Sbjct: 389 LQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRV 448

Query: 92  EVVRELVNYGA-----NVNAQSQKGFTP----------------LYMAAQENHL------ 124
           EV   L+++GA     N + +S     P                L  AA+E  L      
Sbjct: 449 EVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKT 508

Query: 125 ------------------------------EVVKFLLENGANQNVATEDGFTPLAVALQQ 154
                                         +V + LL  GAN N   +D  TPL VA ++
Sbjct: 509 LALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAER 568

Query: 155 GHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPL 210
            H +V+  L  +G K      +   ALH AA     +T  +LL    +P ++S  GFT  
Sbjct: 569 AHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT-- 626

Query: 211 HIAAHYENLNVAQLLLN----RGASVNFTPQNGITPLHIASRRGNVIMVRLLLD-RGAQI 265
             AA   N  V Q+L      R + V++        L  AS+ G++  V+ L   +    
Sbjct: 627 --AAQMGNEAVQQILSESTPIRTSDVDYR-------LLEASKAGDLETVKQLCSSQNVNC 677

Query: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLL 325
                   TPLH AA    V + E LL HGA + AK K GL P+H A    H +   LL+
Sbjct: 678 RDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLV 737

Query: 326 QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR 385
           ++ A ++   L   TPLH AA  G + + K+LL  GA P  +  +G TPL +  K+    
Sbjct: 738 RHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLV-KEGDTD 796

Query: 386 VMELLLKTGASIDAVTESGL----------------------TPLHVASFMGHLPIVKNL 423
           + +LL    A +DA  +  L                      TPLH+A+   +L + + L
Sbjct: 797 IQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYL 856

Query: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
           L+ GA  N  +     PLH AA  GH ++A  L++    VNA  K   TPLH AA+ G T
Sbjct: 857 LEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRT 916

Query: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC 531
            +  LLL + A+P +    G TPL +A  +     ++  +  EA   C
Sbjct: 917 QLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTC 964



 Score =  154 bits (389), Expect = 8e-37
 Identities = 130/450 (28%), Positives = 200/450 (44%), Gaps = 49/450 (10%)

Query: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNV--KVETPLHMAARAGHTE 451
           G  + AV+   L  L  A   G +  VK L+   A+ N  ++  +  +PLH AA  G  +
Sbjct: 173 GTGVPAVS-GALRELLEACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKD 230

Query: 452 VAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAA 511
           V ++LLQ  A V+A+      PLH A   GH  +V LLL   A+PN      +TPLH AA
Sbjct: 231 VVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAA 290

Query: 512 REGHVETVLALLEKEASQACMTKKGFTPLHVA---------AKYGKVRVAE--------- 553
            +G ++  + LL+  A        G + L +A          +Y K  + E         
Sbjct: 291 IKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEK 350

Query: 554 ---LLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAA 610
              LL   + + +A+     TPLH+A  +N + IV+LLL  G   H+    G  PLH A 
Sbjct: 351 LMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNAC 410

Query: 611 KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLT 670
                EV   LL++G   NA  +   TPLH AA +   E+ +LLLS  A+  L N  G +
Sbjct: 411 SYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKS 470

Query: 671 PLHLV---------------------AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
            + +                      A+E  +      +   ++     +   T LH A 
Sbjct: 471 AVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAV 530

Query: 710 ---HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766
              H    ++ + LL+  A+VN K K   +PLH AA++ H D++ +L K+GA  N + + 
Sbjct: 531 ASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTL 590

Query: 767 GTTPLAIAKRLGYISVTDVLKVVTDETSFV 796
           G T L  A   G++    +L     + S +
Sbjct: 591 GQTALHRAALAGHLQTCRLLLSYGSDPSII 620



 Score =  137 bits (346), Expect = 7e-32
 Identities = 101/315 (32%), Positives = 151/315 (47%), Gaps = 11/315 (3%)

Query: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMV 61
           S   R +D     L A+++G+L+  +  L +  ++N  +  G +   LH A+    V +V
Sbjct: 642 STPIRTSDVDYRLLEASKAGDLE-TVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVV 700

Query: 62  VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
             LLH    +    K G   LH A   G  EV   LV +GA+VN      FTPL+ AA +
Sbjct: 701 EYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAK 760

Query: 122 NHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAA 181
              E+ K LL++GA+      DG TPL + +++G  ++   L     +G   L  L  A 
Sbjct: 761 GKYEICKLLLKHGADPTKKNRDGNTPLDL-VKEGDTDIQDLL-----RGDAAL--LDAAK 812

Query: 182 RNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGIT 241
           +    R   +    + N         TPLH+AA Y NL VA+ LL  GA VN   + G+ 
Sbjct: 813 KGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLI 872

Query: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301
           PLH A+  G+V +  LL+     +    K   TPLH AA+ G  ++  +LL HGA    K
Sbjct: 873 PLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMK 932

Query: 302 TKNGLSPIHMAAQGD 316
            + G +P+ +A   D
Sbjct: 933 NQEGQTPLDLATADD 947


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  235 bits (599), Expect = 3e-61
 Identities = 145/398 (36%), Positives = 214/398 (53%), Gaps = 2/398 (0%)

Query: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
           TPLH      ++   +LLL     V+    +G TPL IA++     +  LLL  GA    
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423

Query: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 327
             +D   PLH AA+NG    + +LLDHGA + A+ + G +P+H+AAQ +  +  RLL+  
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483

Query: 328 DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387
            A+ +    +  TPLHVAA+ GH  + K+L  +GA+ +++  N  TPLH+A ++  VR +
Sbjct: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAI 543

Query: 388 ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 447
           + LLK+GA  DA+ +SG  PLH A+  G   I K LL+ GAS  +   +  TPLH+AA  
Sbjct: 544 QHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYK 603

Query: 448 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 507
           GH E+   L ++ A + A    + TPLH AAR G   +V  LL+  A+PN A  +G TPL
Sbjct: 604 GHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPL 663

Query: 508 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 567
           H+A +     +V+ LLE  A+     K G+TP H+AA  G   + ++L+E  A  +    
Sbjct: 664 HLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDG 723

Query: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTP 605
              TPL +A+      I+  L   G  P      G  P
Sbjct: 724 VSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759



 Score =  231 bits (590), Expect = 4e-60
 Identities = 134/389 (34%), Positives = 208/389 (53%)

Query: 270 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 329
           ++++TPLH     G V    +LL H   +  +T +G +P+ +AAQ    D   LLL + A
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419

Query: 330 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMEL 389
           + + +  D   PLH AA  G    A++LLD GA  +++   G+TPLH+A + N   V  L
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479

Query: 390 LLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGH 449
           L+   A  +     G TPLHVA++ GH+ +VK L  +GA  +     + TPLH+A   G 
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539

Query: 450 TEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509
               ++LL++ A  +A  +    PLH AA  G   + K+LL   A+  L T  G TPLH+
Sbjct: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599

Query: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569
           AA +GH+E +  L E  A+   +    +TPLH+AA++G+  V   LL+  A PNAA ++G
Sbjct: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659

Query: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
            TPLH+AV  +    V  LL    + H+    G+TP H+AA +    + + L++ G   +
Sbjct: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719

Query: 630 AESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
            +     TPL LA +     +++ L  K+
Sbjct: 720 VQDGVSCTPLQLALRSRKQGIMSFLEGKE 748



 Score =  223 bits (569), Expect = 1e-57
 Identities = 140/401 (34%), Positives = 204/401 (50%), Gaps = 2/401 (0%)

Query: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429
           N  TPLH    +  V  + LLL     +D  T SG TPL +A+      +   LL  GA 
Sbjct: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420

Query: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489
            N  +     PLH AA+ G    A+ LL + A V+A+ ++  TPLH AA+    N+ +LL
Sbjct: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480

Query: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549
           +   A+PNL    G TPLH+AA  GHV  V  L  + A      +   TPLH+A + GKV
Sbjct: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540

Query: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 609
           R  + LL+  A P+A  ++G  PLH A       I K+LL  G S   P   G+TPLH+A
Sbjct: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600

Query: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
           A +  +E+   L +   +  A      TPLHLAA+ G   +V+ LL   A+ N   +SG 
Sbjct: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660

Query: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
           TPLHL  Q         L++H   V A  ++G+TP H+A+  GN  ++K L++  A ++ 
Sbjct: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720

Query: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 770
           +  +  +PL  A +     I++ L   G  P+  +  G+ P
Sbjct: 721 QDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759



 Score =  218 bits (556), Expect = 3e-56
 Identities = 132/377 (35%), Positives = 198/377 (52%)

Query: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 459
           + E+ +TPLH     G +  V+ LL      +       TPL +AA+    ++   LL +
Sbjct: 358 IYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417

Query: 460 KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519
            A  N   +D   PLH AA+ G     +LLL++ A  +     G TPLH+AA+       
Sbjct: 418 GADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVA 477

Query: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHH 579
             L+ ++A       +G TPLHVAA +G V + +LL  + A  +A  +N  TPLH+AV  
Sbjct: 478 RLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVER 537

Query: 580 NNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPL 639
             +  ++ LL  G  P +   +GY PLH AA + +  + + LL+YG S    + QG TPL
Sbjct: 538 GKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPL 597

Query: 640 HLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTR 699
           HLAA +GH E++ LL    AN         TPLHL A+ G   V   L++ G   +A  +
Sbjct: 598 HLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQ 657

Query: 700 MGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGAS 759
            G+TPLH+A        V  LL+H A+V+A+ K+G++P H AA +G+T I+ +L++ GA 
Sbjct: 658 SGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQ 717

Query: 760 PNEVSSDGTTPLAIAKR 776
            +       TPL +A R
Sbjct: 718 LDVQDGVSCTPLQLALR 734



 Score =  217 bits (553), Expect = 7e-56
 Identities = 134/378 (35%), Positives = 193/378 (51%)

Query: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296
           +N +TPLH    +G+V  VRLLL     ++ +T    TPL  AA++    +  +LL HGA
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419

Query: 297 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 356
                 ++G +P+H AAQ       RLLL + A +D    +  TPLH+AA      VA++
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479

Query: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416
           L+ + A PN     G TPLH+A    HV +++LL   GA +DA   +  TPLH+A   G 
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539

Query: 417 LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 476
           +  +++LL+ GA P+  +     PLH AA  G   + K LL+  A +        TPLH 
Sbjct: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599

Query: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
           AA  GH  ++ LL E++AN         TPLH+AAR G    V ALL+  A      + G
Sbjct: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659

Query: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
           +TPLH+A +         LLE  A+ +A  K G TP H+A    N  I+K+L+  G    
Sbjct: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719

Query: 597 SPAWNGYTPLHIAAKQNQ 614
                  TPL +A +  +
Sbjct: 720 VQDGVSCTPLQLALRSRK 737



 Score =  214 bits (545), Expect = 6e-55
 Identities = 133/400 (33%), Positives = 203/400 (50%), Gaps = 2/400 (0%)

Query: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232
           ++  LH            +LL ++ + D  + +G+TPL IAA  +  ++  LLL  GA  
Sbjct: 362 KVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADA 421

Query: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
           N   ++G  PLH A++ G+    RLLLD GA ++ + ++  TPLH AA+N    ++ +L+
Sbjct: 422 NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLV 481

Query: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352
              A        G +P+H+AA   H+  V+LL    AE+D    +  TPLH+A   G  R
Sbjct: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVR 541

Query: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 412
             + LL  GA P++   +G+ PLH A  +    + ++LL+ GAS++  T  G TPLH+A+
Sbjct: 542 AIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAA 601

Query: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQT 472
           + GHL I+  L +  A+         TPLH+AAR G   V   LLQ  A  NA  +   T
Sbjct: 602 YKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWT 661

Query: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532
           PLH A +      V  LLE++AN +     G TP H+AA +G+   +  L+E  A     
Sbjct: 662 PLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721

Query: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTP 572
                TPL +A +  K  +   L  ++  P+ A   G  P
Sbjct: 722 DGVSCTPLQLALRSRKQGIMSFLEGKE--PSVATLGGSKP 759



 Score =  211 bits (537), Expect = 5e-54
 Identities = 125/372 (33%), Positives = 197/372 (52%)

Query: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
           +N ++P+H       ++ VRLLL ++ ++D  T    TPL +AA      +  +LL  GA
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419

Query: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422
             N    +G+ PLH A +        LLL  GA +DA    G TPLH+A+      + + 
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479

Query: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482
           L+ R A PN+   + +TPLH+AA  GH  + K L    A+++A+ ++ +TPLH A   G 
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539

Query: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542
              ++ LL++ A P+    +G+ PLH AA  G       LL   AS    T +G+TPLH+
Sbjct: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599

Query: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
           AA  G + +  LL E  A+  A G    TPLH+A  H    +V  LL  G  P++   +G
Sbjct: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659

Query: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
           +TPLH+A +++      +LL++  + +A +  G TP HLAA +G+  ++ +L+   A  +
Sbjct: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719

Query: 663 LGNKSGLTPLHL 674
           + +    TPL L
Sbjct: 720 VQDGVSCTPLQL 731



 Score =  208 bits (530), Expect = 3e-53
 Identities = 131/414 (31%), Positives = 215/414 (51%), Gaps = 29/414 (7%)

Query: 43  QNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGA 102
           +N +  LH    +G V+ V  LL  E+ ++  T  G T L IAA   Q ++   L+ +GA
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419

Query: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 162
           + N   + G+ PL+ AAQ       + LL++GA  +    +G+TPL +A Q   ENV   
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENV--- 476

Query: 163 LINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA 222
                                     A +L+    +P++    G TPLH+AA++ ++++ 
Sbjct: 477 --------------------------ARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLV 510

Query: 223 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282
           +LL ++GA ++   +N  TPLH+A  RG V  ++ LL  GA  +   +    PLH AA  
Sbjct: 511 KLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAAR 570

Query: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342
           G   I ++LL +GA ++  T  G +P+H+AA   HL+ + LL +  A +  +   + TPL
Sbjct: 571 GKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPL 630

Query: 343 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE 402
           H+AA  G   V   LL  GA PN+   +G+TPLH+A +++    +  LL+  A++ A  +
Sbjct: 631 HLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNK 690

Query: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
            G TP H+A+  G+  I+K L++ GA  +V +    TPL +A R+    +  +L
Sbjct: 691 VGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744



 Score =  197 bits (500), Expect = 1e-49
 Identities = 135/421 (32%), Positives = 212/421 (50%), Gaps = 31/421 (7%)

Query: 113 TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 172
           TPL+    +  +E V+ LL +  + +  T  G+TPL +A Q    ++ A L+ +G     
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD--- 420

Query: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232
                  A R D+                    G+ PLH AA   +   A+LLL+ GA V
Sbjct: 421 -------ANRVDED-------------------GWAPLHFAAQNGDDGTARLLLDHGACV 454

Query: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
           +   + G TPLH+A++     + RLL+ R A       +  TPLH AA  GHV + ++L 
Sbjct: 455 DAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLT 514

Query: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352
             GA + A+ +N  +P+H+A +   +  ++ LL+  A  D +      PLH AA  G + 
Sbjct: 515 SQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYL 574

Query: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 412
           + K+LL  GA        G+TPLH+A  K H+ ++ LL ++ A++ A+     TPLH+A+
Sbjct: 575 ICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAA 634

Query: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQT 472
             G   +V  LLQ GA PN +     TPLH+A +         LL++ A V+A+ K   T
Sbjct: 635 RHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWT 694

Query: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE-KEASQAC 531
           P H AA  G+T ++K+L+E  A  ++      TPL +A R    + +++ LE KE S A 
Sbjct: 695 PAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALR-SRKQGIMSFLEGKEPSVAT 753

Query: 532 M 532
           +
Sbjct: 754 L 754



 Score =  196 bits (497), Expect = 2e-49
 Identities = 131/380 (34%), Positives = 194/380 (51%), Gaps = 4/380 (1%)

Query: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
           KNL+ R     +   KV TPLH     G  E  + LL ++  V+ +     TPL  AA+ 
Sbjct: 347 KNLVPRDEELCIYENKV-TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQD 405

Query: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
              ++  LLL + A+ N     G  PLH AA+ G   T   LL+  A      ++G+TPL
Sbjct: 406 QQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPL 465

Query: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600
           H+AA+     VA LL+ R A PN     G TPLHVA +  ++ +VKLL  +G    +   
Sbjct: 466 HLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQR 525

Query: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
           N  TPLH+A ++ +V   + LL+ G   +A    G  PLH AA  G   +  +LL   A+
Sbjct: 526 NLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGAS 585

Query: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
             L    G TPLHL A +GH+ +  +L +    + A   + +TPLH+A+ +G   +V  L
Sbjct: 586 LELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645

Query: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780
           LQ  AD NA  + G++PLH A Q+     V  LL++ A+ +  +  G TP  +A   G  
Sbjct: 646 LQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGN- 704

Query: 781 SVTDVLKVVTDETSFVLVSD 800
             T +LKV+ +  + + V D
Sbjct: 705 --TAILKVLVEAGAQLDVQD 722



 Score =  175 bits (443), Expect = 4e-43
 Identities = 117/373 (31%), Positives = 190/373 (50%), Gaps = 6/373 (1%)

Query: 23  GNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTAL 82
           G++++    L + VD++    +G   L +A+++    +   LL          + G   L
Sbjct: 373 GSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPL 432

Query: 83  HIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATE 142
           H AA  G D   R L+++GA V+AQ ++G+TPL++AAQ N   V + L+   A+ N+   
Sbjct: 433 HFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEA 492

Query: 143 DGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRTAAVLLQNDP 197
           +G TPL VA   GH ++V  L + G      +  +R P LH+A      R    LL++  
Sbjct: 493 EGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTP-LHLAVERGKVRAIQHLLKSGA 551

Query: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 257
            PD L ++G+ PLH AA      + ++LL  GAS+      G TPLH+A+ +G++ ++ L
Sbjct: 552 VPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHL 611

Query: 258 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH 317
           L +  A +        TPLH AAR+G   +   LL  GA   A  ++G +P+H+A Q   
Sbjct: 612 LAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRST 671

Query: 318 LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377
              V  LL++ A +        TP H+AA  G+  + KVL++ GA+ + +     TPL +
Sbjct: 672 FLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQL 731

Query: 378 ACKKNHVRVMELL 390
           A +     +M  L
Sbjct: 732 ALRSRKQGIMSFL 744



 Score =  119 bits (299), Expect = 2e-26
 Identities = 83/300 (27%), Positives = 137/300 (45%), Gaps = 31/300 (10%)

Query: 9   EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
           EA+  T    AA  G++         G +++   +N    LHLA + G V+ +  LL   
Sbjct: 491 EAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550

Query: 69  IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
            + +   + G   LH AA  G+  + + L+ YGA++   + +G+TPL++AA + HLE++ 
Sbjct: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610

Query: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRT 188
            L E+ AN        +TPL +A + G E VV                            
Sbjct: 611 LLAESHANMGALGAVNWTPLHLAARHGEEAVV---------------------------- 642

Query: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248
            + LLQ   +P+   ++G+TPLH+A           LL   A+V+   + G TP H+A+ 
Sbjct: 643 -SALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAAL 701

Query: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308
           +GN  ++++L++ GAQ++ +     TPL  A R+    I   L   G      T  G  P
Sbjct: 702 KGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
           sapiens]
          Length = 2603

 Score =  228 bits (580), Expect = 5e-59
 Identities = 202/632 (31%), Positives = 299/632 (47%), Gaps = 51/632 (8%)

Query: 17  LRAARSGNLDKALDHLRNGVDINTCN--QNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
           L ++ S  LD+A   L      +T N  Q+    L  A  EG V  V +LL +   +   
Sbjct: 204 LTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEH 263

Query: 75  TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG-FTPLYMAAQENHLEVVKFLLEN 133
           T++G + L +A  AG  E+ + L+   ANV  +  KG  TPL  AA   H+++VK LL +
Sbjct: 264 TEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAH 323

Query: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLL 193
            A+ N  +  G T L  A   G+ +VV                              VLL
Sbjct: 324 KADVNAQSSTGNTALTYACAGGYVDVV-----------------------------KVLL 354

Query: 194 QNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI--TPLHIASRRGN 251
           ++  + +  ++ G TPL  A    ++ VA+LLL  GA +N T  N    + L +A  +G+
Sbjct: 355 ESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN-THSNEFKESALTLACYKGH 413

Query: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 311
           + MVR LL+ GA  E KT +  T L  A  +GHV ++ +LLD GA +     +  SP+ +
Sbjct: 414 LEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 473

Query: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA-LN 370
           AA G H++   LL++  A ++++  +  TPL  AA  GH  +  +LL +GA  N++    
Sbjct: 474 AACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEET 533

Query: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
             T L +AC    + V + L+K GA I+       TPL  A+  GHL +VK LL  GA+ 
Sbjct: 534 QETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANV 590

Query: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490
           + +    +T L  A   GHT+VA  LLQ  A +  +++  +TPL  AAR GH   V+ L+
Sbjct: 591 HATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLI 650

Query: 491 ENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549
              AN N  T    HT L +A   GH+  V  LL   A      K G T L  AAK G  
Sbjct: 651 SKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 710

Query: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNN------LDIVKLLLPRGGSPHSPAWNGY 603
            V   LL+   +  +A    +T L    H  N      +  + +++P    P  P  N  
Sbjct: 711 SVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVP-PQEPDKPPANVA 769

Query: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
           T L I  K    + + S L     AN++ VQG
Sbjct: 770 TTLPIRNKAASKQKSSSHL----PANSQDVQG 797



 Score =  224 bits (571), Expect = 6e-58
 Identities = 167/513 (32%), Positives = 257/513 (50%), Gaps = 16/513 (3%)

Query: 255 VRLLLDRGAQIETKTKDELTP---------LHCAARNGHVRISEILLDHGAPIQAKTKNG 305
           V   LD  A   T+ + E T          L  A   G V     LL  G  +   T+ G
Sbjct: 208 VSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEG 267

Query: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLD-HLTPLHVAAHCGHHRVAKVLLDKGAKP 364
            S + +A    + +  ++LL   A ++D  +   +TPL  AA+ GH ++ K+LL   A  
Sbjct: 268 ESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADV 327

Query: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
           N+++  G T L  AC   +V V+++LL++GASI+   E+G TPL  A   GH+ + + LL
Sbjct: 328 NAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLL 387

Query: 425 QRGASPNV-SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
           + GA  N  SN   E+ L +A   GH E+ ++LL+  A    K  +  T L  A   GH 
Sbjct: 388 ENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 447

Query: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
            + +LLL++ A  N+   +  +PL +AA  GHVE    L+E+ AS   +  +G+TPL  A
Sbjct: 448 EVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEA 507

Query: 544 AKYGKVRVAELLLERDAHPNAAGKNGL-TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
           A+ G   +  LLL + A+ NA  +    T L +A     L++   L+  G          
Sbjct: 508 AREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGC--- 564

Query: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
            TPL  AA++  +E+ + LL  G + +A +  G T L  A + GH ++  +LL   A+  
Sbjct: 565 STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624

Query: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG-YTPLHVASHYGNIKLVKFLL 721
             ++ G TPL   A+ GHV     LI  G  V+ TT    +T L +A   G++ +V+ LL
Sbjct: 625 HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLL 684

Query: 722 QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
            H AD   + K G + L +AA+ GHT +V  LL
Sbjct: 685 AHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717



 Score =  221 bits (564), Expect = 4e-57
 Identities = 166/474 (35%), Positives = 242/474 (51%), Gaps = 8/474 (1%)

Query: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG- 371
           ++GD ++ VR LL     +++ T +  + L +A   G++ +A+VLL   A    R + G 
Sbjct: 243 SEGD-VNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGD 301

Query: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
            TPL  A    HV++++LLL   A ++A + +G T L  A   G++ +VK LL+ GAS  
Sbjct: 302 ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIE 361

Query: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLL 490
             N    TPL  A  AGH EVA+ LL+N A +N  + +  ++ L  A   GH  MV+ LL
Sbjct: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL 421

Query: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550
           E  A+    T   HT L  A  +GHVE    LL+  A          +PL +AA  G V 
Sbjct: 422 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 481

Query: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY-TPLHIA 609
           +A LL+ER A        G TPL  A    + ++V LLL +G + ++       T L +A
Sbjct: 482 LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLA 541

Query: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
                +EVA  L++ G           TPL  AAQEGH E+V  LL+  AN +    +G 
Sbjct: 542 CCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGD 598

Query: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
           T L    + GH  VADVL++ G  ++  +  G TPL  A+  G++  V+FL+   A+VN 
Sbjct: 599 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658

Query: 730 KT-KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782
            T    ++ L  A   GH  +V LLL +GA P     DG+T L  A + G+ SV
Sbjct: 659 TTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSV 712



 Score =  219 bits (557), Expect = 3e-56
 Identities = 174/509 (34%), Positives = 248/509 (48%), Gaps = 13/509 (2%)

Query: 222 AQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAAR 281
           A L   R  S     Q+    L  A   G+V  VR LL  G  +   T++  + L  A  
Sbjct: 217 AALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACS 276

Query: 282 NGHVRISEILLDHGAPIQAK-TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLT 340
            G+  ++++LL   A ++ +  K  ++P+  AA G H+  V+LLL + A+++  +    T
Sbjct: 277 AGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNT 336

Query: 341 PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
            L  A   G+  V KVLL+ GA       NG TPL  A    HV V  LLL+ GA I+  
Sbjct: 337 ALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTH 396

Query: 401 T----ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
           +    ES LT   +A + GHL +V+ LL+ GA       ++ T L  A   GH EVA+ L
Sbjct: 397 SNEFKESALT---LACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 453

Query: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
           L + A+VN  A   ++PL  AA  GH  +  LL+E  A+       G+TPL  AAREGH 
Sbjct: 454 LDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHE 513

Query: 517 ETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 575
           E V  LL + A+    T++   T L +A   G + VA+ L++  A          TPL  
Sbjct: 514 EMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLME 570

Query: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
           A    +L++VK LL  G + H+    G T L  A +    +VA  LLQ G     ES  G
Sbjct: 571 AAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 630

Query: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMV 694
            TPL  AA+ GH   V  L+SK AN N     +  T L L    GH+ V ++L+ HG   
Sbjct: 631 RTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADP 690

Query: 695 DATTRMGYTPLHVASHYGNIKLVKFLLQH 723
               + G T L  A+  G+  +V +LL +
Sbjct: 691 THRLKDGSTMLIEAAKGGHTSVVCYLLDY 719



 Score =  206 bits (525), Expect = 1e-52
 Identities = 178/555 (32%), Positives = 254/555 (45%), Gaps = 38/555 (6%)

Query: 91  DEVVRELVNYGANVNAQS-QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 149
           DE    L    A   A + Q     L  A  E  +  V+ LL  G + N  TE+G + L 
Sbjct: 213 DEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLC 272

Query: 150 VALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 209
           +A   G+  +   L+           A+H    +                    K   TP
Sbjct: 273 LACSAGYYELAQVLL-----------AMHANVEDRGI-----------------KGDITP 304

Query: 210 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 269
           L  AA+  ++ + +LLL   A VN     G T L  A   G V +V++LL+ GA IE   
Sbjct: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHN 364

Query: 270 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN-GLSPIHMAAQGDHLDCVRLLLQYD 328
           ++  TPL  A   GHV ++ +LL++GA I   +     S + +A    HL+ VR LL+  
Sbjct: 365 ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAG 424

Query: 329 AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVME 388
           A+ +  T +  T L  A   GH  VA++LLD GA+ N  A +  +PL +A    HV +  
Sbjct: 425 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 484

Query: 389 LLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARA 447
           LL++ GAS++ V + G TPL  A+  GH  +V  LL +GA+ N    +  ET L +A   
Sbjct: 485 LLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCG 544

Query: 448 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 507
           G  EVA +L++  A +        TPL  AA+ GH  +VK LL   AN +  T  G T L
Sbjct: 545 GFLEVADFLIKAGADIELGC---STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTAL 601

Query: 508 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN-AAG 566
             A   GH +    LL+  A     ++ G TPL  AA+ G V   + L+ + A+ N    
Sbjct: 602 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTA 661

Query: 567 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626
            N  T L +A    +L +V+LLL  G  P     +G T L  AAK     V   LL Y  
Sbjct: 662 NNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPN 721

Query: 627 ---SANAESVQGVTP 638
              SA    V  +TP
Sbjct: 722 NLLSAPPPDVTQLTP 736



 Score =  205 bits (522), Expect = 3e-52
 Identities = 160/485 (32%), Positives = 241/485 (49%), Gaps = 11/485 (2%)

Query: 15  SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
           S   A   G+++     L  G  +N   + G + L LA   G+ ++   LL     +E  
Sbjct: 237 SLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 296

Query: 75  TKKGN-TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
             KG+ T L  AA  G  ++V+ L+ + A+VNAQS  G T L  A    +++VVK LLE+
Sbjct: 297 GIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES 356

Query: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRT 188
           GA+     E+G TPL  A   GH  V   L+  G        + +  AL +A        
Sbjct: 357 GASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEM 416

Query: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248
              LL+   + +  +    T L  A    ++ VA+LLL+ GA VN    +  +PL +A+ 
Sbjct: 417 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 476

Query: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-S 307
            G+V +  LL++RGA +E    +  TPL  AAR GH  +  +LL  GA I A+T+    +
Sbjct: 477 GGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQET 536

Query: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367
            + +A  G  L+    L++  A   DI L   TPL  AA  GH  + K LL  GA  ++ 
Sbjct: 537 ALTLACCGGFLEVADFLIKAGA---DIELGCSTPLMEAAQEGHLELVKYLLAAGANVHAT 593

Query: 368 ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427
              G T L  AC+  H  V ++LL+ GA ++  +E G TPL  A+  GH+  V+ L+ +G
Sbjct: 594 TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKG 653

Query: 428 ASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486
           A+ N +    + T L +A   GH  V + LL + A    + KD  T L  AA+ GHT++V
Sbjct: 654 ANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVV 713

Query: 487 KLLLE 491
             LL+
Sbjct: 714 CYLLD 718



 Score =  199 bits (506), Expect = 2e-50
 Identities = 146/412 (35%), Positives = 209/412 (50%), Gaps = 6/412 (1%)

Query: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
           AC +  V  +  LL  G S++  TE G + L +A   G+  + + LL   A+     +K 
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300

Query: 438 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
           + TPL  AA  GH ++ K LL +KA VNA++    T L  A   G+ ++VK+LLE+ A+ 
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360

Query: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 555
                 GHTPL  A   GHVE    LLE  A     + +   + L +A   G + +   L
Sbjct: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420

Query: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615
           LE  A          T L  A    ++++ +LLL  G   + PA +  +PL +AA    V
Sbjct: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480

Query: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 674
           E+A  L++ G S    + +G TPL  AA+EGH EMVALLL + AN N   +    T L L
Sbjct: 481 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540

Query: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734
               G + VAD LIK G  ++       TPL  A+  G+++LVK+LL   A+V+A T  G
Sbjct: 541 ACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATG 597

Query: 735 YSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
            + L  A + GHTD+  +LL+ GA     S  G TPL  A R G++     L
Sbjct: 598 DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL 649



 Score =  196 bits (497), Expect = 2e-49
 Identities = 253/996 (25%), Positives = 391/996 (39%), Gaps = 116/996 (11%)

Query: 9    EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
            E   +T  + AA+ G+L+     L  G +++     G   L  A + GH  +   LL   
Sbjct: 561  ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAG 620

Query: 69   IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVV 127
              LE  ++ G T L  AA AG    V+ L++ GANVN   +    T L +A    HL VV
Sbjct: 621  ADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVV 680

Query: 128  KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA----------- 176
            + LL +GA+     +DG T L  A + GH +VV +L++Y        P            
Sbjct: 681  ELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHD 740

Query: 177  LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN----RGASV 232
            L+ A R        V+   +P+    +     P+   A  +  + + L  N    +G   
Sbjct: 741  LNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAASKQKSSSHLPANSQDVQGYIT 800

Query: 233  NFTP-------QNGITPLHIASRRG---NVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282
            N +P       Q  +T L    +     N  +  L L    Q+  +  +EL         
Sbjct: 801  NQSPESIVEEAQGKLTELEQRIKEAIEKNAQLQSLELAHADQLTKEKIEELNKTREEQIQ 860

Query: 283  GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342
               +I E L      +Q KT+  L   ++  +       R+ LQ   +     L  LTP+
Sbjct: 861  KKQKILEELQKVERELQLKTQQQLKKQYLEVKAQ-----RIQLQQQQQQSCQHLGLLTPV 915

Query: 343  HVAAHCGHHRVAKV-----LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI 397
             V         A++     +L K     + A  GF P+        + +    L  G SI
Sbjct: 916  GVGEQLSEGDYARLQQVDPVLLKDEPQQTAAQMGFAPIQPLAMPQALPLAAGPLPPG-SI 974

Query: 398  DAVTE-----SGLTPLHVASFMGHLPIVKNLLQRG---ASPNVSNVKVETPLHMAARAGH 449
              +TE      G   L  A   G    +    Q+G   ASP    +       MAA +G 
Sbjct: 975  ANLTELQGVIVGQPVLGQAQLAGLGQGILTETQQGLMVASP-AQTLNDTLDDIMAAVSGR 1033

Query: 450  TEVAKYLLQNKAKVNAKAKDDQTP---LHCAARIGHTNMVKLLLENNANPNLATTAGHTP 506
                     +    +       TP   +  +A +     + +  +  +N + A T     
Sbjct: 1034 ASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALT----- 1088

Query: 507  LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566
              +A   GH E V  LLE+ AS     KKGFTPL +AA  G V V E+LL+  A   A  
Sbjct: 1089 --LACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQS 1146

Query: 567  KNGL-TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYG 625
            +    TPL +A      ++V+LLL RG +      + YTPL +AA    V + + LL  G
Sbjct: 1147 ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 1206

Query: 626  GSANAE--SVQGVTPLHLAAQEGH----------------------------------AE 649
               N+   S  G++PL LAA  GH                                   E
Sbjct: 1207 AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTE 1266

Query: 650  MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA--TTRMGYTPLHV 707
            +V+LLL ++AN     K+GLTPL   A  G+  V  VL+  G  V+A        T L +
Sbjct: 1267 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1326

Query: 708  ASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767
            A+  G+ K  + L+   A ++ + K G +PL  AA  GH D+V LL++ GA  +   +  
Sbjct: 1327 AADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1386

Query: 768  TTPLAIAKRLGYISVTDVL-KVVTDETS-------FVLVSDKHRMS----FPETVDEILD 815
             TPL  A R G++ V   L K V    S          ++DK  +       E++ +  D
Sbjct: 1387 ITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKD 1446

Query: 816  VSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVES---------PAIPRIPCAM 866
                E  +  S   E  D   + EE   L    K ++  E            +  I    
Sbjct: 1447 RQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKN 1506

Query: 867  PETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNI 902
             E   +++ ++++  K  DE  ++   P+  T+  I
Sbjct: 1507 KENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTI 1542



 Score =  184 bits (466), Expect = 9e-46
 Identities = 150/464 (32%), Positives = 217/464 (46%), Gaps = 35/464 (7%)

Query: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
           T  + AA  G++      L +  D+N  +  G   L  A   G+V +V  LL     +E 
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362

Query: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132
             + G+T L  A  AG  EV R L+  GA +N  S +   + L +A  + HLE+V+FLLE
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422

Query: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192
            GA+Q   T++  T L  A   GH  V   L++ G   +V +PA                
Sbjct: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPA---------------- 464

Query: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252
                       +  +PL +AA   ++ +A LL+ RGAS+      G TPL  A+R G+ 
Sbjct: 465 -----------DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHE 513

Query: 253 IMVRLLLDRGAQIETKTKD-ELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 311
            MV LLL +GA I  +T++ + T L  A   G + +++ L+  GA I+       +P+  
Sbjct: 514 EMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLME 570

Query: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371
           AAQ  HL+ V+ LL   A +   T    T L  A   GH  VA VLL  GA     +  G
Sbjct: 571 AAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 630

Query: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVT-ESGLTPLHVASFMGHLPIVKNLLQRGASP 430
            TPL  A +  HV  ++ L+  GA+++  T  +  T L +A   GHL +V+ LL  GA P
Sbjct: 631 RTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADP 690

Query: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474
                   T L  AA+ GHT V  YLL     + +    D T L
Sbjct: 691 THRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQL 734



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 41/131 (31%), Positives = 67/131 (51%), Gaps = 2/131 (1%)

Query: 4    SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMV 61
            +V  R     T  + AA  G  +     L  G D+N      +    L +A+ +GH K  
Sbjct: 1277 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1336

Query: 62   VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
              L+ +   ++   KKGNT L +AA  G  +VV+ LV  GA+V+A   +  TPL  A ++
Sbjct: 1337 ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRK 1396

Query: 122  NHLEVVKFLLE 132
             H++VV++L++
Sbjct: 1397 GHVKVVRYLVK 1407


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
           [Homo sapiens]
          Length = 2542

 Score =  223 bits (569), Expect = 1e-57
 Identities = 168/485 (34%), Positives = 243/485 (50%), Gaps = 13/485 (2%)

Query: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308
           G+V  VR LLD G  +   T++  + L  A   G+  ++++LL   A ++ +   G ++P
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275

Query: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
           +  A+ G +LD V+LLL +DA+++  +    T L  A   G   + KVLL++GA      
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335

Query: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424
            NG TPL  A    HV V  +LL  GA I+  +    ES LT   +A + GHL +V+ LL
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392

Query: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
           + GA       ++ T L  A   GH EVA+ LL + A+VN  A   ++PL  AA  GH  
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452

Query: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543
           +  LL+E  AN       G+TPL  AAREGH E V  LL + A+    T++   T L +A
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512

Query: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603
              G   VA+ L++  A          TPL  A    +L++VK LL  G + H+    G 
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569

Query: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
           T L  A +    +VA  LLQ G     ES  G TPL  AA+ GH   V  L+SK AN N 
Sbjct: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNR 629

Query: 664 GN-KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
               +  T + L    GH+ V ++L+ HG       + G T L  A+  G+  +V +LL 
Sbjct: 630 ATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689

Query: 723 HQADV 727
           +  +V
Sbjct: 690 YPNNV 694



 Score =  222 bits (565), Expect = 3e-57
 Identities = 173/517 (33%), Positives = 255/517 (49%), Gaps = 41/517 (7%)

Query: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
           A  +G V  V +LL +   +   T++G + L +A  AG  E+ + L+   ANV  +  KG
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271

Query: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170
             TPL  A+   +L++VK LL + A+ N  +  G T L  A   G  ++V  L+N G   
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 329

Query: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230
                                      N +  ++ G TPL  AA   ++ VA++LL+ GA
Sbjct: 330 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362

Query: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
            +N T  N    + L +A  +G++ MVR LL+ GA  E KT +  T L  A  +GHV ++
Sbjct: 363 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 421

Query: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348
            +LLD GA +     +  SP+ +AA G H++   LL++  A ++++  +  TPL  AA  
Sbjct: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481

Query: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407
           GH  +  +LL +GA  N++      T L +AC      V + L+K GA I+       TP
Sbjct: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 538

Query: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
           L  AS  GHL +VK LL  GA+ + +    +T L  A   GHT+VA  LLQ  A +  ++
Sbjct: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598

Query: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKE 526
           +  +TPL  AAR GH   V+ L+   AN N AT    HT + +A   GH+  V  LL   
Sbjct: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658

Query: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
           A      K G T L  AAK G   V   LL+   +PN
Sbjct: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD---YPN 692



 Score =  208 bits (530), Expect = 3e-53
 Identities = 168/515 (32%), Positives = 255/515 (49%), Gaps = 19/515 (3%)

Query: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG- 371
           + GD ++ VR LL     +++ T +  + L +A   G++ +A+VLL   A    R   G 
Sbjct: 214 SDGD-VNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGD 272

Query: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
            TPL  A    ++ +++LLL   A +++ + +G T L  A   G + IVK LL  GA+  
Sbjct: 273 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 332

Query: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLL 490
             N    TPL  AA AGH EVA+ LL + A +N  + +  ++ L  A   GH +MV+ LL
Sbjct: 333 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 392

Query: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550
           E  A+    T   HT L  A  +GHVE    LL+  A          +PL +AA  G V 
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452

Query: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY-TPLHIA 609
           +A LL+ER A+       G TPL  A    + ++V LLL +G + ++       T L +A
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512

Query: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
                 EVA  L++ G           TPL  A+QEGH E+V  LL+  AN +    +G 
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569

Query: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN- 728
           T L    + GH  VADVL++ G  ++  +  G TPL  A+  G++  V+FL+   A+VN 
Sbjct: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNR 629

Query: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKV 788
           A     ++ +  A   GH  +V LLL +GA P     DG+T L  A + G+         
Sbjct: 630 ATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGH--------- 680

Query: 789 VTDETSFVLVSDKHRMSFPET-VDEILDVSEDEGE 822
            T+  S++L    + +S P T V ++   S+D+ +
Sbjct: 681 -TNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQ 714



 Score =  198 bits (504), Expect = 4e-50
 Identities = 146/453 (32%), Positives = 226/453 (49%), Gaps = 35/453 (7%)

Query: 42  NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
           N+  +  L  AS  G++ +V  LL  +  + + +  GNTAL  A   G  ++V+ L+N G
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328

Query: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160
           AN+   ++ G TPL  AA   H+EV + LL++GA  N  + E   + L +A  +GH ++V
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388

Query: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220
             L+  G   + +   +H                             T L  A    ++ 
Sbjct: 389 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 419

Query: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
           VA+LLL+ GA VN    +  +PL +A+  G+V +  LL++RGA +E    +  TPL  AA
Sbjct: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479

Query: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339
           R GH  +  +LL  GA I A+T+    + + +A  G   +    L++  A   DI L   
Sbjct: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 536

Query: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
           TPL  A+  GH  + K LL  GA  ++    G T L  AC+  H  V ++LL+ GA ++ 
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596

Query: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQ 458
            +E G TPL  A+  GHL  V+ L+ +GA+ N +    + T + +A   GH  V + LL 
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656

Query: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
           + A    + KD  T L  AA+ GHTN+V  LL+
Sbjct: 657 HGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689



 Score =  177 bits (450), Expect = 7e-44
 Identities = 139/420 (33%), Positives = 210/420 (50%), Gaps = 14/420 (3%)

Query: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
           T  + A+  G LD     L +  D+N+ +  G   L  A   G V +V  LL++   +E 
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333

Query: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132
             + G+T L  AA AG  EV R L+++GA +N  S +   + L +A  + HL++V+FLLE
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393

Query: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------LHIAARNDDT 186
            GA+Q   T++  T L  A   GH  V   L++ G   +V +PA      L +AA     
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPLTLAACGGHV 451

Query: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHI 245
             AA+L++   N + ++  G+TPL  AA   +  +  LLL +GA++N  T +   T L +
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511

Query: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
           A   G   +   L+  GA IE       TPL  A++ GH+ + + LL  GA + A T  G
Sbjct: 512 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 568

Query: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
            + +  A +  H D   +LLQ  A+++  +    TPL  AA  GH    + L+ KGA  N
Sbjct: 569 DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVN 628

Query: 366 -SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
            + A N  T + +AC   H+ V+ELLL  GA      + G T L  A+  GH  +V  LL
Sbjct: 629 RATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688



 Score =  160 bits (405), Expect = 1e-38
 Identities = 126/398 (31%), Positives = 197/398 (49%), Gaps = 35/398 (8%)

Query: 14  TSFLRAARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILE 72
           T  + AA +G+++ A   L +G  INT  N+   + L LA  +GH+ MV  LL      E
Sbjct: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399

Query: 73  TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
             T + +TAL  A + G  EV R L++ GA VN  +    +PL +AA   H+E+   L+E
Sbjct: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459

Query: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192
            GAN     ++G+TPL  A ++GHE +VA L+  G          +I A+ ++T+  A+ 
Sbjct: 460 RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA---------NINAQTEETQETALT 510

Query: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252
           L            GF+            VA  L+  GA +        TPL  AS+ G++
Sbjct: 511 L--------ACCGGFS-----------EVADFLIKAGADIEL---GCSTPLMEASQEGHL 548

Query: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
            +V+ LL  GA +   T    T L  A  NGH  ++++LL  GA ++ +++ G +P+  A
Sbjct: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 608

Query: 313 AQGDHLDCVRLLLQYDAEIDDITL--DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370
           A+  HL  V+ L+   A ++  T   DH T + +A   GH  V ++LL  GA P  R  +
Sbjct: 609 ARAGHLCTVQFLISKGANVNRATANNDH-TVVSLACAGGHLAVVELLLAHGADPTHRLKD 667

Query: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
           G T L  A K  H  V+  LL    ++ +V  + ++ L
Sbjct: 668 GSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQL 705



 Score =  157 bits (398), Expect = 7e-38
 Identities = 135/485 (27%), Positives = 229/485 (47%), Gaps = 33/485 (6%)

Query: 438  ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
            +T L +A   GH E+   L+   AK+  + K   TPL  AA  GH  +V++LL+   +  
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115

Query: 498  LATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
              +     TPL +A   G  E V  LL + A++       +TPL +AA  G V + ++LL
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175

Query: 557  ERDAHPNA--AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA-WNGYTPLHIAAKQN 613
               A  N+    K G++PL +A  + ++  VKLLL  G   ++    N  T L +A  Q 
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235

Query: 614  QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN--KSGLTP 671
            + EV   LL    +    +  G+TPL  AA  G+AE+  +LL K A+ N      S  T 
Sbjct: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295

Query: 672  LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731
            L + A +GH    ++LI  G  +D   + G TPL +AS+ G+  +V+ L+Q  ADV+A  
Sbjct: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355

Query: 732  KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK---- 787
                +PL  A ++GH  +V  L+K     N+  SD    +   + +  I+  ++LK    
Sbjct: 1356 NRKITPLMSAFRKGHVKVVQYLVK---EVNQFPSD----IECMRYIATITDKELLKKCHQ 1408

Query: 788  ----VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKEL 843
                +V  +      ++K+     + +D      E   + L + + +R++ R   +E++ 
Sbjct: 1409 CVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKKEEQ- 1467

Query: 844  LDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLI-PSSPATETSDNI 902
                 K  Q  +    P+    +PE      E++E+  ++ +++  I P S  T T+  I
Sbjct: 1468 -----KRKQEEDEENKPKENSELPE-----DEDEEENDEDVEQEVPIEPPSATTTTTIGI 1517

Query: 903  SPVAS 907
            S  ++
Sbjct: 1518 SATSA 1522



 Score =  157 bits (396), Expect = 1e-37
 Identities = 119/333 (35%), Positives = 166/333 (49%), Gaps = 7/333 (2%)

Query: 397  IDAVTESGL-TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
            IDA TES   T L +A   GH  +V  L+ R A     + K  TPL +AA AGH  V + 
Sbjct: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106

Query: 456  LLQNKAKVNAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 514
            LL     + A++ +   TPL  A   G   +V LLL   AN      + +TPL +AA  G
Sbjct: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166

Query: 515  HVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLT 571
            +V  +  LL    E +    +K G +PL +AA  G V   +LLL+  +  NA  + N  T
Sbjct: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226

Query: 572  PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
             L +A      ++V LLL R  +    A  G TPL  AA     EV R LL  G   NA 
Sbjct: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286

Query: 632  SVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
             V     T L +AA +GH +   LL+ + A+ ++ NK G TPL L +  GH  V  +L++
Sbjct: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346

Query: 690  HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
             G  VDA      TPL  A   G++K+V++L++
Sbjct: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379



 Score =  157 bits (396), Expect = 1e-37
 Identities = 113/327 (34%), Positives = 168/327 (51%), Gaps = 6/327 (1%)

Query: 337  DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
            +H T L +A   GH  +  VL+ + AK   R   GFTPL +A    HV V+E+LL  G  
Sbjct: 1054 NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD 1113

Query: 397  IDAVTE-SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
            I+A +E +  TPL +A   G   +V  LL RGA+    NV   TPL +AA  G+  + K 
Sbjct: 1114 IEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1173

Query: 456  LLQNKAKVNAK--AKDDQTPLHCAARIGHTNMVKLLLENNANPNL-ATTAGHTPLHIAAR 512
            LL   A++N++  +K   +PL  AA  GH   VKLLL+  ++ N    T  +T L +A  
Sbjct: 1174 LLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACF 1233

Query: 513  EGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA--AGKNGL 570
            +G  E V  LL+++A+     K G TPL  AA  G   V  +LL++ A  NA     +  
Sbjct: 1234 QGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1293

Query: 571  TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
            T L +A    +    +LL+ RG         G TPL +A+     +V + L+Q G   +A
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353

Query: 631  ESVQGVTPLHLAAQEGHAEMVALLLSK 657
               + +TPL  A ++GH ++V  L+ +
Sbjct: 1354 ADNRKITPLMSAFRKGHVKVVQYLVKE 1380



 Score =  155 bits (393), Expect = 3e-37
 Identities = 121/381 (31%), Positives = 187/381 (49%), Gaps = 24/381 (6%)

Query: 36   VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
            +D +T   N    L LA   GH ++V  L+ ++  +E   KKG T L +AA AG   VV 
Sbjct: 1047 IDAHT-ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105

Query: 96   ELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 154
             L++ G ++ AQS++   TPL +A      EVV  LL  GAN+       +TPL++A   
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165

Query: 155  GHENVVAHLINYG------TKGKVRLPALHIAARNDDTRTAAVLLQ--NDPNPDVLSKTG 206
            G+ N++  L+N G      T  K+ +  L +AA N       +LL   +D N  + +   
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225

Query: 207  FTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 266
             T L +A       V  LLL+R A+V    + G+TPL  A+  G   + R+LLD+GA + 
Sbjct: 1226 -TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284

Query: 267  TK--TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
                     T L  AA  GH +  E+L+  GA I  + K G +P+ +A+ G H D V+LL
Sbjct: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344

Query: 325  LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHV 384
            +Q  A++D      +TPL  A   GH +V + L+        + +N F P  I C +   
Sbjct: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV--------KEVNQF-PSDIECMRYIA 1395

Query: 385  RV--MELLLKTGASIDAVTES 403
             +   ELL K    ++ + ++
Sbjct: 1396 TITDKELLKKCHQCVETIVKA 1416



 Score =  155 bits (392), Expect = 3e-37
 Identities = 114/322 (35%), Positives = 163/322 (50%), Gaps = 39/322 (12%)

Query: 176  ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF- 234
            AL +A         +VL+  D   +   K GFTPL +AA   ++ V ++LL++G  +   
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117

Query: 235  TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294
            + +   TPL +A   G   +V LLL RGA  E +   + TPL  AA  G+V I +ILL+ 
Sbjct: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177

Query: 295  GAPIQAKT--KNGLSPIHMAAQGDHLDCVRLLL-----------------------QYDA 329
            GA I ++T  K G+SP+ +AA   H+  V+LLL                       Q  A
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237

Query: 330  EIDDITLDH-----------LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF--TPLH 376
            E+  + LD            LTPL  AA  G+  V +VLLDKGA  N+  +     T L 
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297

Query: 377  IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK 436
            IA  K H +  ELL+  GA ID   + G TPL +AS  GH  +V+ L+Q GA  + ++ +
Sbjct: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1357

Query: 437  VETPLHMAARAGHTEVAKYLLQ 458
              TPL  A R GH +V +YL++
Sbjct: 1358 KITPLMSAFRKGHVKVVQYLVK 1379



 Score =  141 bits (355), Expect = 7e-33
 Identities = 125/403 (31%), Positives = 174/403 (43%), Gaps = 67/403 (16%)

Query: 451 EVAKYLLQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509
           E A  L + KA+ +  A   D   L  A   G  N V+ LL+   + N  T  G + L +
Sbjct: 185 EAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCL 244

Query: 510 AAREGHVETVLALLEKEASQACMTKKG-FTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 568
           A   G+ E    LL   A+      KG  TPL  A+  G + + +LLL  DA  N+    
Sbjct: 245 ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSAT 304

Query: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628
           G T L  A     +DIVK+LL  G +      NG+TPL  AA    VEVAR LL +G   
Sbjct: 305 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 364

Query: 629 NAESVQGV----------------------------------TPLHLAAQEGHAEMVALL 654
           N  S +                                    T L  A  +GH E+  LL
Sbjct: 365 NTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 424

Query: 655 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNI 714
           L   A  N+   S  +PL L A  GHV +A +LI+ G  ++     GYTPL  A+  G+ 
Sbjct: 425 LDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHE 484

Query: 715 KLVKFLLQHQADVNAKT------------------------------KLGYS-PLHQAAQ 743
           ++V  LL   A++NA+T                              +LG S PL +A+Q
Sbjct: 485 EMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQ 544

Query: 744 QGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
           +GH ++V  LL +GA+ +  ++ G T L  A   G+  V DVL
Sbjct: 545 EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587



 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 53/159 (33%), Positives = 82/159 (51%), Gaps = 1/159 (0%)

Query: 9   EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
           E   +T  + A++ G+L+     L +G +++     G   L  A + GH  +   LL   
Sbjct: 532 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591

Query: 69  IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVV 127
             LE  ++ G T L  AA AG    V+ L++ GANVN A +    T + +A    HL VV
Sbjct: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVV 651

Query: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
           + LL +GA+     +DG T L  A + GH NVV++L++Y
Sbjct: 652 ELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 41/131 (31%), Positives = 68/131 (51%), Gaps = 2/131 (1%)

Query: 4    SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMV 61
            +V  R     T  + AA  G  +     L  G D+N      +    L +A+ +GH K  
Sbjct: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1308

Query: 62   VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
              L+H+   ++   KKGNT L +A+  G  +VV+ LV  GA+V+A   +  TPL  A ++
Sbjct: 1309 ELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRK 1368

Query: 122  NHLEVVKFLLE 132
             H++VV++L++
Sbjct: 1369 GHVKVVQYLVK 1379


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score =  223 bits (569), Expect = 1e-57
 Identities = 168/485 (34%), Positives = 243/485 (50%), Gaps = 13/485 (2%)

Query: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308
           G+V  VR LLD G  +   T++  + L  A   G+  ++++LL   A ++ +   G ++P
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275

Query: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
           +  A+ G +LD V+LLL +DA+++  +    T L  A   G   + KVLL++GA      
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335

Query: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424
            NG TPL  A    HV V  +LL  GA I+  +    ES LT   +A + GHL +V+ LL
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392

Query: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
           + GA       ++ T L  A   GH EVA+ LL + A+VN  A   ++PL  AA  GH  
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452

Query: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543
           +  LL+E  AN       G+TPL  AAREGH E V  LL + A+    T++   T L +A
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512

Query: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603
              G   VA+ L++  A          TPL  A    +L++VK LL  G + H+    G 
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569

Query: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
           T L  A +    +VA  LLQ G     ES  G TPL  AA+ GH   V  L+SK AN N 
Sbjct: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNR 629

Query: 664 GN-KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
               +  T + L    GH+ V ++L+ HG       + G T L  A+  G+  +V +LL 
Sbjct: 630 ATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689

Query: 723 HQADV 727
           +  +V
Sbjct: 690 YPNNV 694



 Score =  222 bits (565), Expect = 3e-57
 Identities = 173/517 (33%), Positives = 255/517 (49%), Gaps = 41/517 (7%)

Query: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
           A  +G V  V +LL +   +   T++G + L +A  AG  E+ + L+   ANV  +  KG
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271

Query: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170
             TPL  A+   +L++VK LL + A+ N  +  G T L  A   G  ++V  L+N G   
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 329

Query: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230
                                      N +  ++ G TPL  AA   ++ VA++LL+ GA
Sbjct: 330 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362

Query: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
            +N T  N    + L +A  +G++ MVR LL+ GA  E KT +  T L  A  +GHV ++
Sbjct: 363 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 421

Query: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348
            +LLD GA +     +  SP+ +AA G H++   LL++  A ++++  +  TPL  AA  
Sbjct: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481

Query: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407
           GH  +  +LL +GA  N++      T L +AC      V + L+K GA I+       TP
Sbjct: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 538

Query: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
           L  AS  GHL +VK LL  GA+ + +    +T L  A   GHT+VA  LLQ  A +  ++
Sbjct: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598

Query: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKE 526
           +  +TPL  AAR GH   V+ L+   AN N AT    HT + +A   GH+  V  LL   
Sbjct: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658

Query: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
           A      K G T L  AAK G   V   LL+   +PN
Sbjct: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD---YPN 692



 Score =  208 bits (530), Expect = 3e-53
 Identities = 168/515 (32%), Positives = 255/515 (49%), Gaps = 19/515 (3%)

Query: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG- 371
           + GD ++ VR LL     +++ T +  + L +A   G++ +A+VLL   A    R   G 
Sbjct: 214 SDGD-VNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGD 272

Query: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
            TPL  A    ++ +++LLL   A +++ + +G T L  A   G + IVK LL  GA+  
Sbjct: 273 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 332

Query: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLL 490
             N    TPL  AA AGH EVA+ LL + A +N  + +  ++ L  A   GH +MV+ LL
Sbjct: 333 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 392

Query: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550
           E  A+    T   HT L  A  +GHVE    LL+  A          +PL +AA  G V 
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452

Query: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY-TPLHIA 609
           +A LL+ER A+       G TPL  A    + ++V LLL +G + ++       T L +A
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512

Query: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
                 EVA  L++ G           TPL  A+QEGH E+V  LL+  AN +    +G 
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569

Query: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN- 728
           T L    + GH  VADVL++ G  ++  +  G TPL  A+  G++  V+FL+   A+VN 
Sbjct: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNR 629

Query: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKV 788
           A     ++ +  A   GH  +V LLL +GA P     DG+T L  A + G+         
Sbjct: 630 ATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGH--------- 680

Query: 789 VTDETSFVLVSDKHRMSFPET-VDEILDVSEDEGE 822
            T+  S++L    + +S P T V ++   S+D+ +
Sbjct: 681 -TNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQ 714



 Score =  198 bits (504), Expect = 4e-50
 Identities = 146/453 (32%), Positives = 226/453 (49%), Gaps = 35/453 (7%)

Query: 42  NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
           N+  +  L  AS  G++ +V  LL  +  + + +  GNTAL  A   G  ++V+ L+N G
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328

Query: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160
           AN+   ++ G TPL  AA   H+EV + LL++GA  N  + E   + L +A  +GH ++V
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388

Query: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220
             L+  G   + +   +H                             T L  A    ++ 
Sbjct: 389 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 419

Query: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
           VA+LLL+ GA VN    +  +PL +A+  G+V +  LL++RGA +E    +  TPL  AA
Sbjct: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479

Query: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339
           R GH  +  +LL  GA I A+T+    + + +A  G   +    L++  A   DI L   
Sbjct: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 536

Query: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
           TPL  A+  GH  + K LL  GA  ++    G T L  AC+  H  V ++LL+ GA ++ 
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596

Query: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQ 458
            +E G TPL  A+  GHL  V+ L+ +GA+ N +    + T + +A   GH  V + LL 
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656

Query: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
           + A    + KD  T L  AA+ GHTN+V  LL+
Sbjct: 657 HGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689



 Score =  177 bits (450), Expect = 7e-44
 Identities = 139/420 (33%), Positives = 210/420 (50%), Gaps = 14/420 (3%)

Query: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
           T  + A+  G LD     L +  D+N+ +  G   L  A   G V +V  LL++   +E 
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333

Query: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132
             + G+T L  AA AG  EV R L+++GA +N  S +   + L +A  + HL++V+FLLE
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393

Query: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------LHIAARNDDT 186
            GA+Q   T++  T L  A   GH  V   L++ G   +V +PA      L +AA     
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPLTLAACGGHV 451

Query: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHI 245
             AA+L++   N + ++  G+TPL  AA   +  +  LLL +GA++N  T +   T L +
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511

Query: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
           A   G   +   L+  GA IE       TPL  A++ GH+ + + LL  GA + A T  G
Sbjct: 512 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 568

Query: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
            + +  A +  H D   +LLQ  A+++  +    TPL  AA  GH    + L+ KGA  N
Sbjct: 569 DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVN 628

Query: 366 -SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
            + A N  T + +AC   H+ V+ELLL  GA      + G T L  A+  GH  +V  LL
Sbjct: 629 RATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688



 Score =  160 bits (405), Expect = 1e-38
 Identities = 126/398 (31%), Positives = 197/398 (49%), Gaps = 35/398 (8%)

Query: 14  TSFLRAARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILE 72
           T  + AA +G+++ A   L +G  INT  N+   + L LA  +GH+ MV  LL      E
Sbjct: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399

Query: 73  TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
             T + +TAL  A + G  EV R L++ GA VN  +    +PL +AA   H+E+   L+E
Sbjct: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459

Query: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192
            GAN     ++G+TPL  A ++GHE +VA L+  G          +I A+ ++T+  A+ 
Sbjct: 460 RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA---------NINAQTEETQETALT 510

Query: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252
           L            GF+            VA  L+  GA +        TPL  AS+ G++
Sbjct: 511 L--------ACCGGFS-----------EVADFLIKAGADIEL---GCSTPLMEASQEGHL 548

Query: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
            +V+ LL  GA +   T    T L  A  NGH  ++++LL  GA ++ +++ G +P+  A
Sbjct: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 608

Query: 313 AQGDHLDCVRLLLQYDAEIDDITL--DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370
           A+  HL  V+ L+   A ++  T   DH T + +A   GH  V ++LL  GA P  R  +
Sbjct: 609 ARAGHLCTVQFLISKGANVNRATANNDH-TVVSLACAGGHLAVVELLLAHGADPTHRLKD 667

Query: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
           G T L  A K  H  V+  LL    ++ +V  + ++ L
Sbjct: 668 GSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQL 705



 Score =  157 bits (398), Expect = 7e-38
 Identities = 135/485 (27%), Positives = 229/485 (47%), Gaps = 33/485 (6%)

Query: 438  ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
            +T L +A   GH E+   L+   AK+  + K   TPL  AA  GH  +V++LL+   +  
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115

Query: 498  LATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
              +     TPL +A   G  E V  LL + A++       +TPL +AA  G V + ++LL
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175

Query: 557  ERDAHPNA--AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA-WNGYTPLHIAAKQN 613
               A  N+    K G++PL +A  + ++  VKLLL  G   ++    N  T L +A  Q 
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235

Query: 614  QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN--KSGLTP 671
            + EV   LL    +    +  G+TPL  AA  G+AE+  +LL K A+ N      S  T 
Sbjct: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295

Query: 672  LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731
            L + A +GH    ++LI  G  +D   + G TPL +AS+ G+  +V+ L+Q  ADV+A  
Sbjct: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355

Query: 732  KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK---- 787
                +PL  A ++GH  +V  L+K     N+  SD    +   + +  I+  ++LK    
Sbjct: 1356 NRKITPLMSAFRKGHVKVVQYLVK---EVNQFPSD----IECMRYIATITDKELLKKCHQ 1408

Query: 788  ----VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKEL 843
                +V  +      ++K+     + +D      E   + L + + +R++ R   +E++ 
Sbjct: 1409 CVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKKEEQ- 1467

Query: 844  LDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLI-PSSPATETSDNI 902
                 K  Q  +    P+    +PE      E++E+  ++ +++  I P S  T T+  I
Sbjct: 1468 -----KRKQEEDEENKPKENSELPE-----DEDEEENDEDVEQEVPIEPPSATTTTTIGI 1517

Query: 903  SPVAS 907
            S  ++
Sbjct: 1518 SATSA 1522



 Score =  157 bits (396), Expect = 1e-37
 Identities = 119/333 (35%), Positives = 166/333 (49%), Gaps = 7/333 (2%)

Query: 397  IDAVTESGL-TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
            IDA TES   T L +A   GH  +V  L+ R A     + K  TPL +AA AGH  V + 
Sbjct: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106

Query: 456  LLQNKAKVNAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 514
            LL     + A++ +   TPL  A   G   +V LLL   AN      + +TPL +AA  G
Sbjct: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166

Query: 515  HVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLT 571
            +V  +  LL    E +    +K G +PL +AA  G V   +LLL+  +  NA  + N  T
Sbjct: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226

Query: 572  PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
             L +A      ++V LLL R  +    A  G TPL  AA     EV R LL  G   NA 
Sbjct: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286

Query: 632  SVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
             V     T L +AA +GH +   LL+ + A+ ++ NK G TPL L +  GH  V  +L++
Sbjct: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346

Query: 690  HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
             G  VDA      TPL  A   G++K+V++L++
Sbjct: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379



 Score =  157 bits (396), Expect = 1e-37
 Identities = 113/327 (34%), Positives = 168/327 (51%), Gaps = 6/327 (1%)

Query: 337  DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
            +H T L +A   GH  +  VL+ + AK   R   GFTPL +A    HV V+E+LL  G  
Sbjct: 1054 NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD 1113

Query: 397  IDAVTE-SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
            I+A +E +  TPL +A   G   +V  LL RGA+    NV   TPL +AA  G+  + K 
Sbjct: 1114 IEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1173

Query: 456  LLQNKAKVNAK--AKDDQTPLHCAARIGHTNMVKLLLENNANPNL-ATTAGHTPLHIAAR 512
            LL   A++N++  +K   +PL  AA  GH   VKLLL+  ++ N    T  +T L +A  
Sbjct: 1174 LLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACF 1233

Query: 513  EGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA--AGKNGL 570
            +G  E V  LL+++A+     K G TPL  AA  G   V  +LL++ A  NA     +  
Sbjct: 1234 QGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1293

Query: 571  TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
            T L +A    +    +LL+ RG         G TPL +A+     +V + L+Q G   +A
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353

Query: 631  ESVQGVTPLHLAAQEGHAEMVALLLSK 657
               + +TPL  A ++GH ++V  L+ +
Sbjct: 1354 ADNRKITPLMSAFRKGHVKVVQYLVKE 1380



 Score =  155 bits (393), Expect = 3e-37
 Identities = 121/381 (31%), Positives = 187/381 (49%), Gaps = 24/381 (6%)

Query: 36   VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
            +D +T   N    L LA   GH ++V  L+ ++  +E   KKG T L +AA AG   VV 
Sbjct: 1047 IDAHT-ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105

Query: 96   ELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 154
             L++ G ++ AQS++   TPL +A      EVV  LL  GAN+       +TPL++A   
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165

Query: 155  GHENVVAHLINYG------TKGKVRLPALHIAARNDDTRTAAVLLQ--NDPNPDVLSKTG 206
            G+ N++  L+N G      T  K+ +  L +AA N       +LL   +D N  + +   
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225

Query: 207  FTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 266
             T L +A       V  LLL+R A+V    + G+TPL  A+  G   + R+LLD+GA + 
Sbjct: 1226 -TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284

Query: 267  TK--TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
                     T L  AA  GH +  E+L+  GA I  + K G +P+ +A+ G H D V+LL
Sbjct: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344

Query: 325  LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHV 384
            +Q  A++D      +TPL  A   GH +V + L+        + +N F P  I C +   
Sbjct: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV--------KEVNQF-PSDIECMRYIA 1395

Query: 385  RV--MELLLKTGASIDAVTES 403
             +   ELL K    ++ + ++
Sbjct: 1396 TITDKELLKKCHQCVETIVKA 1416



 Score =  155 bits (392), Expect = 3e-37
 Identities = 114/322 (35%), Positives = 163/322 (50%), Gaps = 39/322 (12%)

Query: 176  ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF- 234
            AL +A         +VL+  D   +   K GFTPL +AA   ++ V ++LL++G  +   
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117

Query: 235  TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294
            + +   TPL +A   G   +V LLL RGA  E +   + TPL  AA  G+V I +ILL+ 
Sbjct: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177

Query: 295  GAPIQAKT--KNGLSPIHMAAQGDHLDCVRLLL-----------------------QYDA 329
            GA I ++T  K G+SP+ +AA   H+  V+LLL                       Q  A
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237

Query: 330  EIDDITLDH-----------LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF--TPLH 376
            E+  + LD            LTPL  AA  G+  V +VLLDKGA  N+  +     T L 
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297

Query: 377  IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK 436
            IA  K H +  ELL+  GA ID   + G TPL +AS  GH  +V+ L+Q GA  + ++ +
Sbjct: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1357

Query: 437  VETPLHMAARAGHTEVAKYLLQ 458
              TPL  A R GH +V +YL++
Sbjct: 1358 KITPLMSAFRKGHVKVVQYLVK 1379



 Score =  141 bits (355), Expect = 7e-33
 Identities = 125/403 (31%), Positives = 174/403 (43%), Gaps = 67/403 (16%)

Query: 451 EVAKYLLQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509
           E A  L + KA+ +  A   D   L  A   G  N V+ LL+   + N  T  G + L +
Sbjct: 185 EAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCL 244

Query: 510 AAREGHVETVLALLEKEASQACMTKKG-FTPLHVAAKYGKVRVAELLLERDAHPNAAGKN 568
           A   G+ E    LL   A+      KG  TPL  A+  G + + +LLL  DA  N+    
Sbjct: 245 ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSAT 304

Query: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628
           G T L  A     +DIVK+LL  G +      NG+TPL  AA    VEVAR LL +G   
Sbjct: 305 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 364

Query: 629 NAESVQGV----------------------------------TPLHLAAQEGHAEMVALL 654
           N  S +                                    T L  A  +GH E+  LL
Sbjct: 365 NTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 424

Query: 655 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNI 714
           L   A  N+   S  +PL L A  GHV +A +LI+ G  ++     GYTPL  A+  G+ 
Sbjct: 425 LDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHE 484

Query: 715 KLVKFLLQHQADVNAKT------------------------------KLGYS-PLHQAAQ 743
           ++V  LL   A++NA+T                              +LG S PL +A+Q
Sbjct: 485 EMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQ 544

Query: 744 QGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
           +GH ++V  LL +GA+ +  ++ G T L  A   G+  V DVL
Sbjct: 545 EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587



 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 53/159 (33%), Positives = 82/159 (51%), Gaps = 1/159 (0%)

Query: 9   EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
           E   +T  + A++ G+L+     L +G +++     G   L  A + GH  +   LL   
Sbjct: 532 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591

Query: 69  IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVV 127
             LE  ++ G T L  AA AG    V+ L++ GANVN A +    T + +A    HL VV
Sbjct: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVV 651

Query: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
           + LL +GA+     +DG T L  A + GH NVV++L++Y
Sbjct: 652 ELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 41/131 (31%), Positives = 68/131 (51%), Gaps = 2/131 (1%)

Query: 4    SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMV 61
            +V  R     T  + AA  G  +     L  G D+N      +    L +A+ +GH K  
Sbjct: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1308

Query: 62   VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
              L+H+   ++   KKGNT L +A+  G  +VV+ LV  GA+V+A   +  TPL  A ++
Sbjct: 1309 ELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRK 1368

Query: 122  NHLEVVKFLLE 132
             H++VV++L++
Sbjct: 1369 GHVKVVQYLVK 1379


>gi|34304381 inversin isoform a [Homo sapiens]
          Length = 1065

 Score =  199 bits (507), Expect = 2e-50
 Identities = 150/506 (29%), Positives = 245/506 (48%), Gaps = 18/506 (3%)

Query: 78  GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
           G T L    LA + +    L+  GA+VN       T L++AAQ+ +   +K LL   AN 
Sbjct: 48  GRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANW 107

Query: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV------RLPALHIAARNDDTRTAAV 191
                +  TPL +  +      +A L+ +   G+V      +  ALH +A  ++     +
Sbjct: 108 MQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKL 167

Query: 192 LLQNDPNPDVLSKTGFTPLHIAAHYEN---LNVAQLLLNRGAS---VNFTPQNGITPLHI 245
           L+++D N  +    G  PLH AA++++   ++  + +L+   +   +N+    G TPLH 
Sbjct: 168 LIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHF 227

Query: 246 ASRRGNVIMVRLLLD-RGAQIETKTKDELTPLHCAARNGHVRISEILLDHG-APIQAKTK 303
           A   GNV +V +L       I +      TPLH AA  GH +I  +LL+   +       
Sbjct: 228 AVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS 287

Query: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD--KG 361
            G +P+H AAQ +  + V++ L++ +  DD  L+  T    AA  G   V + +L     
Sbjct: 288 QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSD 347

Query: 362 AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVK 421
              N     G T LH A    HV  ++LLL+  A +DA      TPL  A  MGH  +++
Sbjct: 348 IDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQ 407

Query: 422 NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481
            L++ GA  ++ +    + LH AA  G+ +V + L++NK   N +    +TPL CAA  G
Sbjct: 408 TLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGG 467

Query: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA--SQACMTKKGFTP 539
           + N + +L+ENNA+PN+    G T LH +   G+++ +  LL+  A  +Q    ++ +TP
Sbjct: 468 YINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTP 527

Query: 540 LHVAAKYGKVRVAELLLERDAHPNAA 565
           L  A    +  V + +LE  A   AA
Sbjct: 528 LDYALLGERHEVIQFMLEHGALSIAA 553



 Score =  191 bits (485), Expect = 6e-48
 Identities = 156/531 (29%), Positives = 245/531 (46%), Gaps = 21/531 (3%)

Query: 82  LHIAALAGQDEVVREL-VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVA 140
           +H AA+ G    ++ L V   A  + + Q G TPL      + L+    LL+ GA+ N  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 141 TEDGFTPLAVALQQGHENVVAHLI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQ-- 194
                T L +A Q+G+   +  L+    N+  K    +  LH+  R+   +  A+LL+  
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN--- 251
                D   K   T LH +A+Y N    +LL+   +++      G  PLH A+   +   
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197

Query: 252 VIMVRLLLDRG---AQIETKTKDELTPLHCAARNGHVRISEILLDH-GAPIQAKTKNGLS 307
           V  VR +LD     + +  +  +  TPLH A  +G+V + ++L  +    I +      +
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257

Query: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDH--LTPLHVAAHCGHHRVAKVLLDKGAKPN 365
           P+H AA   H   V LLL+ +     I  D    TPLH AA        KV L   +  +
Sbjct: 258 PLHWAALLGHAQIVHLLLERNKS-GTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKD 316

Query: 366 SRALNGFTPLHIACKKNHVRVME--LLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
              L G T    A  K    V+   L LK+   I+   + G T LH A+  GH+  VK L
Sbjct: 317 DSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLL 376

Query: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
           L+  A  + ++V   TPL  A   GH +V + L++  A+V+   +D  + LH AA  G+ 
Sbjct: 377 LENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNA 436

Query: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
           ++ ++L+EN  NPN+   AG TPL  AA  G++  +  L+E  A      K+G T LH +
Sbjct: 437 DVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWS 496

Query: 544 AKYGKVRVAELLLERDAHPNAAGKN--GLTPLHVAVHHNNLDIVKLLLPRG 592
              G +   +LLL+  A PN    N    TPL  A+     ++++ +L  G
Sbjct: 497 CNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHG 547



 Score =  184 bits (466), Expect = 9e-46
 Identities = 165/637 (25%), Positives = 287/637 (45%), Gaps = 40/637 (6%)

Query: 276 LHCAARNGHV-RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI 334
           +H AA NG    +  +++ + A    + + G +P+      D LDC   LL+  A+++  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 335 TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 394
                T LH+AA  G++R  K+LL + A    + L   TPLH+  +    + + LLLK  
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 395 A--SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR-----A 447
           A   +D   ++  T LH +++  +   VK L++  ++  + +V+ + PLH AA      A
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197

Query: 448 GHTEVAKYLLQ---NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE-NNANPNLATTAG 503
            HT   + +L     ++ +N +  + +TPLH A   G+  +V +L    + N        
Sbjct: 198 VHT--VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLF 255

Query: 504 HTPLHIAAREGHVETVLALLEKEASQACMT-KKGFTPLHVAAKYGKVRVAELLLERDAHP 562
            TPLH AA  GH + V  LLE+  S    +  +G TPLH AA+       ++ L+  +  
Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVK 315

Query: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY--TPLHIAAKQNQVEVARS 620
           + +   G T    A    + D+++ +L           + Y  T LH AA    V   + 
Sbjct: 316 DDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKL 375

Query: 621 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680
           LL+     +A  V   TPL  A + GH +++  L+   A  +L ++ G + LH  A  G+
Sbjct: 376 LLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGN 435

Query: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 740
             V  +LI++ +  +     G TPL  A++ G I  +  L+++ AD N + K G + LH 
Sbjct: 436 ADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHW 495

Query: 741 AAQQGHTDIVTLLLKNGASPNEV--SSDGTTPLAIA------------KRLGYISVTDVL 786
           +   G+ D + LLL   A PN++  + +  TPL  A               G +S+  + 
Sbjct: 496 SCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQ 555

Query: 787 KVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDF 846
            +   +   V    K R +F +    +L   E   ++  + K E  + R   E++     
Sbjct: 556 DIAAFKIQAVYKGYKVRKAFRDR-KNLLMKHEQLRKDAAAKKREEENKRKEAEQQ----- 609

Query: 847 VPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKE 883
             K  +  +S     +PC +P T  + S +    SK+
Sbjct: 610 --KGRRSPDSCRPQALPC-LPSTQDVPSRQSRAPSKQ 643



 Score =  166 bits (421), Expect = 1e-40
 Identities = 145/529 (27%), Positives = 235/529 (44%), Gaps = 45/529 (8%)

Query: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
           T  +    +  LD A   L+ G D+N  + +    LHLA+++G+ + +  LL +      
Sbjct: 50  TPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQ 109

Query: 74  TTKKGNTALHIAALAGQDEVVRELVNYGA--NVNAQSQKGFTPLYMAAQENHLEVVKFLL 131
              +  T LH+       + +  L+ + A   V+ Q +   T L+ +A  N+ E VK L+
Sbjct: 110 KDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLI 169

Query: 132 ENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDD---TRT 188
           ++ +N  +   +G  P                             LH AA + D     T
Sbjct: 170 KHDSNIGIPDVEGKIP-----------------------------LHWAANHKDPSAVHT 200

Query: 189 AAVLLQNDPNPDVLS---KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI--TPL 243
              +L   P   +L+     G TPLH A    N+ V  +L +   S N T  + +  TPL
Sbjct: 201 VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY-ESCNITSYDNLFRTPL 259

Query: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDE-LTPLHCAARNGHVRISEILLDHGAPIQAKT 302
           H A+  G+  +V LLL+R       +  +  TPLH AA++      ++ L H +      
Sbjct: 260 HWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSD 319

Query: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDK 360
             G +    AA     D +R +L   ++ID    D    T LH AA  GH    K+LL+ 
Sbjct: 320 LEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLEN 379

Query: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
            A+ ++  +   TPL  AC+  H  V++ L+K GA +D V + G + LH A+  G+  + 
Sbjct: 380 NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVC 439

Query: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
           + L++   +PNV +    TPL  AA  G+      L++N A  N + K+ +T LH +   
Sbjct: 440 QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNN 499

Query: 481 GHTNMVKLLLENNANPNLA--TTAGHTPLHIAAREGHVETVLALLEKEA 527
           G+ + +KLLL+  A PN        +TPL  A      E +  +LE  A
Sbjct: 500 GYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 74/259 (28%), Positives = 118/259 (45%), Gaps = 33/259 (12%)

Query: 9   EADAATSFLRAARSGNLD--KALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH 66
           + +  TSF+ AA  G+ D  + +  L++ +DIN  ++ G   LH A+  GHV  V  LL 
Sbjct: 319 DLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLE 378

Query: 67  KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126
               ++ T    +T L  A   G  +V++ L+  GA V+   Q G + L+ AA   + +V
Sbjct: 379 NNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADV 438

Query: 127 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186
            + L+EN  N NV    G TPL  A   G+ N +                          
Sbjct: 439 CQILIENKINPNVQDYAGRTPLQCAAYGGYINCM-------------------------- 472

Query: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLH 244
              AVL++N+ +P++  K G T LH + +   L+  +LLL+  A  N    N    TPL 
Sbjct: 473 ---AVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLD 529

Query: 245 IASRRGNVIMVRLLLDRGA 263
            A       +++ +L+ GA
Sbjct: 530 YALLGERHEVIQFMLEHGA 548


>gi|34304379 inversin isoform b [Homo sapiens]
          Length = 895

 Score =  199 bits (507), Expect = 2e-50
 Identities = 150/506 (29%), Positives = 245/506 (48%), Gaps = 18/506 (3%)

Query: 78  GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
           G T L    LA + +    L+  GA+VN       T L++AAQ+ +   +K LL   AN 
Sbjct: 48  GRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANW 107

Query: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV------RLPALHIAARNDDTRTAAV 191
                +  TPL +  +      +A L+ +   G+V      +  ALH +A  ++     +
Sbjct: 108 MQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKL 167

Query: 192 LLQNDPNPDVLSKTGFTPLHIAAHYEN---LNVAQLLLNRGAS---VNFTPQNGITPLHI 245
           L+++D N  +    G  PLH AA++++   ++  + +L+   +   +N+    G TPLH 
Sbjct: 168 LIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHF 227

Query: 246 ASRRGNVIMVRLLLD-RGAQIETKTKDELTPLHCAARNGHVRISEILLDHG-APIQAKTK 303
           A   GNV +V +L       I +      TPLH AA  GH +I  +LL+   +       
Sbjct: 228 AVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS 287

Query: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD--KG 361
            G +P+H AAQ +  + V++ L++ +  DD  L+  T    AA  G   V + +L     
Sbjct: 288 QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSD 347

Query: 362 AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVK 421
              N     G T LH A    HV  ++LLL+  A +DA      TPL  A  MGH  +++
Sbjct: 348 IDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQ 407

Query: 422 NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481
            L++ GA  ++ +    + LH AA  G+ +V + L++NK   N +    +TPL CAA  G
Sbjct: 408 TLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGG 467

Query: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA--SQACMTKKGFTP 539
           + N + +L+ENNA+PN+    G T LH +   G+++ +  LL+  A  +Q    ++ +TP
Sbjct: 468 YINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTP 527

Query: 540 LHVAAKYGKVRVAELLLERDAHPNAA 565
           L  A    +  V + +LE  A   AA
Sbjct: 528 LDYALLGERHEVIQFMLEHGALSIAA 553



 Score =  191 bits (485), Expect = 6e-48
 Identities = 156/531 (29%), Positives = 245/531 (46%), Gaps = 21/531 (3%)

Query: 82  LHIAALAGQDEVVREL-VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVA 140
           +H AA+ G    ++ L V   A  + + Q G TPL      + L+    LL+ GA+ N  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 141 TEDGFTPLAVALQQGHENVVAHLI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQ-- 194
                T L +A Q+G+   +  L+    N+  K    +  LH+  R+   +  A+LL+  
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN--- 251
                D   K   T LH +A+Y N    +LL+   +++      G  PLH A+   +   
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197

Query: 252 VIMVRLLLDRG---AQIETKTKDELTPLHCAARNGHVRISEILLDH-GAPIQAKTKNGLS 307
           V  VR +LD     + +  +  +  TPLH A  +G+V + ++L  +    I +      +
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257

Query: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDH--LTPLHVAAHCGHHRVAKVLLDKGAKPN 365
           P+H AA   H   V LLL+ +     I  D    TPLH AA        KV L   +  +
Sbjct: 258 PLHWAALLGHAQIVHLLLERNKS-GTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKD 316

Query: 366 SRALNGFTPLHIACKKNHVRVME--LLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
              L G T    A  K    V+   L LK+   I+   + G T LH A+  GH+  VK L
Sbjct: 317 DSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLL 376

Query: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
           L+  A  + ++V   TPL  A   GH +V + L++  A+V+   +D  + LH AA  G+ 
Sbjct: 377 LENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNA 436

Query: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
           ++ ++L+EN  NPN+   AG TPL  AA  G++  +  L+E  A      K+G T LH +
Sbjct: 437 DVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWS 496

Query: 544 AKYGKVRVAELLLERDAHPNAAGKN--GLTPLHVAVHHNNLDIVKLLLPRG 592
              G +   +LLL+  A PN    N    TPL  A+     ++++ +L  G
Sbjct: 497 CNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHG 547



 Score =  184 bits (466), Expect = 9e-46
 Identities = 165/637 (25%), Positives = 287/637 (45%), Gaps = 40/637 (6%)

Query: 276 LHCAARNGHV-RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI 334
           +H AA NG    +  +++ + A    + + G +P+      D LDC   LL+  A+++  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 335 TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 394
                T LH+AA  G++R  K+LL + A    + L   TPLH+  +    + + LLLK  
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 395 A--SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR-----A 447
           A   +D   ++  T LH +++  +   VK L++  ++  + +V+ + PLH AA      A
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197

Query: 448 GHTEVAKYLLQ---NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE-NNANPNLATTAG 503
            HT   + +L     ++ +N +  + +TPLH A   G+  +V +L    + N        
Sbjct: 198 VHT--VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLF 255

Query: 504 HTPLHIAAREGHVETVLALLEKEASQACMT-KKGFTPLHVAAKYGKVRVAELLLERDAHP 562
            TPLH AA  GH + V  LLE+  S    +  +G TPLH AA+       ++ L+  +  
Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVK 315

Query: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY--TPLHIAAKQNQVEVARS 620
           + +   G T    A    + D+++ +L           + Y  T LH AA    V   + 
Sbjct: 316 DDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKL 375

Query: 621 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680
           LL+     +A  V   TPL  A + GH +++  L+   A  +L ++ G + LH  A  G+
Sbjct: 376 LLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGN 435

Query: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 740
             V  +LI++ +  +     G TPL  A++ G I  +  L+++ AD N + K G + LH 
Sbjct: 436 ADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHW 495

Query: 741 AAQQGHTDIVTLLLKNGASPNEV--SSDGTTPLAIA------------KRLGYISVTDVL 786
           +   G+ D + LLL   A PN++  + +  TPL  A               G +S+  + 
Sbjct: 496 SCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQ 555

Query: 787 KVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDF 846
            +   +   V    K R +F +    +L   E   ++  + K E  + R   E++     
Sbjct: 556 DIAAFKIQAVYKGYKVRKAFRDR-KNLLMKHEQLRKDAAAKKREEENKRKEAEQQ----- 609

Query: 847 VPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKE 883
             K  +  +S     +PC +P T  + S +    SK+
Sbjct: 610 --KGRRSPDSCRPQALPC-LPSTQDVPSRQSRAPSKQ 643



 Score =  166 bits (421), Expect = 1e-40
 Identities = 145/529 (27%), Positives = 235/529 (44%), Gaps = 45/529 (8%)

Query: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
           T  +    +  LD A   L+ G D+N  + +    LHLA+++G+ + +  LL +      
Sbjct: 50  TPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQ 109

Query: 74  TTKKGNTALHIAALAGQDEVVRELVNYGA--NVNAQSQKGFTPLYMAAQENHLEVVKFLL 131
              +  T LH+       + +  L+ + A   V+ Q +   T L+ +A  N+ E VK L+
Sbjct: 110 KDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLI 169

Query: 132 ENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDD---TRT 188
           ++ +N  +   +G  P                             LH AA + D     T
Sbjct: 170 KHDSNIGIPDVEGKIP-----------------------------LHWAANHKDPSAVHT 200

Query: 189 AAVLLQNDPNPDVLS---KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI--TPL 243
              +L   P   +L+     G TPLH A    N+ V  +L +   S N T  + +  TPL
Sbjct: 201 VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY-ESCNITSYDNLFRTPL 259

Query: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDE-LTPLHCAARNGHVRISEILLDHGAPIQAKT 302
           H A+  G+  +V LLL+R       +  +  TPLH AA++      ++ L H +      
Sbjct: 260 HWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSD 319

Query: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDK 360
             G +    AA     D +R +L   ++ID    D    T LH AA  GH    K+LL+ 
Sbjct: 320 LEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLEN 379

Query: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
            A+ ++  +   TPL  AC+  H  V++ L+K GA +D V + G + LH A+  G+  + 
Sbjct: 380 NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVC 439

Query: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
           + L++   +PNV +    TPL  AA  G+      L++N A  N + K+ +T LH +   
Sbjct: 440 QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNN 499

Query: 481 GHTNMVKLLLENNANPNLA--TTAGHTPLHIAAREGHVETVLALLEKEA 527
           G+ + +KLLL+  A PN        +TPL  A      E +  +LE  A
Sbjct: 500 GYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 74/259 (28%), Positives = 118/259 (45%), Gaps = 33/259 (12%)

Query: 9   EADAATSFLRAARSGNLD--KALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH 66
           + +  TSF+ AA  G+ D  + +  L++ +DIN  ++ G   LH A+  GHV  V  LL 
Sbjct: 319 DLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLE 378

Query: 67  KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126
               ++ T    +T L  A   G  +V++ L+  GA V+   Q G + L+ AA   + +V
Sbjct: 379 NNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADV 438

Query: 127 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186
            + L+EN  N NV    G TPL  A   G+ N +                          
Sbjct: 439 CQILIENKINPNVQDYAGRTPLQCAAYGGYINCM-------------------------- 472

Query: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLH 244
              AVL++N+ +P++  K G T LH + +   L+  +LLL+  A  N    N    TPL 
Sbjct: 473 ---AVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLD 529

Query: 245 IASRRGNVIMVRLLLDRGA 263
            A       +++ +L+ GA
Sbjct: 530 YALLGERHEVIQFMLEHGA 548


>gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform 1
            [Homo sapiens]
          Length = 1170

 Score =  197 bits (502), Expect = 6e-50
 Identities = 221/817 (27%), Positives = 338/817 (41%), Gaps = 85/817 (10%)

Query: 38   INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97
            +N  + NG   L LA       +   L+  +  ++   K G + LH     G       L
Sbjct: 249  LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308

Query: 98   VNYGANVNAQSQKGF-TPLYMAA-----------QENHLEVVKFLLENGANQNVATEDGF 145
            +  GA VNA +     TPL++ A                ++ + LL+ GAN N+    G 
Sbjct: 309  IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368

Query: 146  TPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL-LQNDPNPDVLSK 204
            TPL V++  G+E V + L+        +   L +  ++ +  TA  L +Q+       S 
Sbjct: 369  TPLHVSIMAGNEYVFSQLL--------QCKQLDLELKDHEGSTALWLAVQHITVSSDQSV 420

Query: 205  TGF--TPLHIAAHYENLNVAQLLLNRGASVNFTPQ-NGITPLHIASRRGNVIMVRLLLDR 261
              F   P+     ++  + A  L+ RG+  +      G   L  A+  GN      L   
Sbjct: 421  NPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATN 480

Query: 262  GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL--------------- 306
            GA +  + K   TPLH A R+G   ++  LL  GA    +T+  L               
Sbjct: 481  GAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADS 540

Query: 307  ----SPIHMAAQGDHLDCVRLLLQYDAE----------IDDITLDHL---TPLHVAAHCG 349
                +P+HMA   +H D V ++L+  A           I D +L      T L +A   G
Sbjct: 541  VHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTG 600

Query: 350  HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV-TESGLTPL 408
             H +A  LL  GA  N    +G T LH+A ++   +    LL+  A I+   T+ G T L
Sbjct: 601  MHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETAL 660

Query: 409  HVASFMGHLPIVKNLL-QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
             +A     LP+V + +  RGA  +V + K   PL +A      ++A  L+++        
Sbjct: 661  QLA-IRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWG 719

Query: 468  KDD----QTPLHCAARIGHTNMVKLLLENNANPNLATTAG------------HTPLHIAA 511
                   QT LH A    +      L+ +  + N     G             TPLH+AA
Sbjct: 720  PGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAA 779

Query: 512  REGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER-DAHPNAAGKNGL 570
              G  ETV  LLE  A+      +G TP+HVA       + +LL+   D H N   + GL
Sbjct: 780  SWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGL 839

Query: 571  TPLHVAVHHNNLDIVKLLLPR-GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
            TP   A+   N    + +L R  G+       G   LH+A + + +E    L+    + N
Sbjct: 840  TPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVN 899

Query: 630  A--ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVL 687
            +  +    +TPLHLA Q G   +V  LL   A  N   K   T LHL AQ+    +  VL
Sbjct: 900  SRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVL 959

Query: 688  IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL-QHQADVNAKTKLGYSPLHQAAQQGH 746
            +++GV   A    G   LH+A  +G +  ++ LL +   D  A    G SPLH   Q G 
Sbjct: 960  LENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGK 1019

Query: 747  TD---IVTLLLK--NGASPNEVSSDGTTPLAIAKRLG 778
             +   I  L L+   G   ++  +DG+T L +A   G
Sbjct: 1020 ENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKG 1056



 Score =  185 bits (469), Expect = 4e-46
 Identities = 206/750 (27%), Positives = 310/750 (41%), Gaps = 88/750 (11%)

Query: 114 PLYMAAQENHLEVVKFLLENGANQ-----NVATEDGFTPLAVALQQGHENV----VAHLI 164
           PL+ A +    +VV   L    +Q     N A  +G   L +AL +  E++    V+H  
Sbjct: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280

Query: 165 NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP--NPDVLSKTGFTPLHIAAHY------ 216
           +     K     LH   +  D   A  L++N    N   L     TPLH+ A Y      
Sbjct: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQE-TPLHLVALYSSKKHS 339

Query: 217 -----ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN-VIMVRLLLDRGAQIETKTK 270
                E   +A+ LL  GA+ N     G TPLH++   GN  +  +LL  +   +E K  
Sbjct: 340 ADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDH 399

Query: 271 DELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
           +  T L  A +  H+ +S          Q+       P+      D       L+Q  + 
Sbjct: 400 EGSTALWLAVQ--HITVSSD--------QSVNPFEDVPVVNGTSFDENSFAARLIQRGSH 449

Query: 331 ID-DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMEL 389
            D   T      L  AA  G+   A  L   GA  N R   G TPLH AC+     +   
Sbjct: 450 TDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAE 509

Query: 390 LLKTGASIDAVTESGL-------------------TPLHVASFMGHLPIVKNLLQRGASP 430
           LL+ GA+ +  TE  L                   TPLH+A    H  +V  +L++ A+ 
Sbjct: 510 LLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANA 569

Query: 431 -------------NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477
                        ++ + + +T L +A   G   +A  LL + A +N    D QT LH A
Sbjct: 570 LHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMA 629

Query: 478 ARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
            +   +     LLE+ A+ N++ T  G T L +A R      V A+  + A  +   +KG
Sbjct: 630 IQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKG 689

Query: 537 FTPLHVAAKYGKVRVAELLLER--DAHPNAAGKNGL--TPLHVAVHHNNLDIVKLLLPRG 592
             PL +A       +A  L+    DA     G  G   T LH A+  NN      L+  G
Sbjct: 690 NPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSG 749

Query: 593 ---GSPHSPAWNG---------YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLH 640
               SP  P  NG          TPLH+AA     E  + LL++G + NA+  +G TP+H
Sbjct: 750 CDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIH 809

Query: 641 LAAQEGHAEMVALLLS-KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATT 698
           +A    H  ++ LL+S    + N+ ++ GLTP        +   A+ ++K      +   
Sbjct: 810 VAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVD 869

Query: 699 RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTK--LGYSPLHQAAQQGHTDIVTLLLKN 756
             G   LHVA    +I+ V FL+   A+VN++ +     +PLH A Q G   IV  LL  
Sbjct: 870 NKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLA 929

Query: 757 GASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
           GA  NE++    T L +A +    ++  VL
Sbjct: 930 GAKVNELTKHRQTALHLAAQQDLPTICSVL 959



 Score =  152 bits (384), Expect = 3e-36
 Identities = 161/619 (26%), Positives = 257/619 (41%), Gaps = 58/619 (9%)

Query: 18   RAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKK 77
            RAA +GN   AL    NG  +N  N+ G   LH A + G   +  ELL          + 
Sbjct: 464  RAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQ---------QG 514

Query: 78   GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
             N  L         +    L +   +V+ Q     TPL+MA   NH +VV  +LE  AN 
Sbjct: 515  ANPNLQTEEALPLPKEAASLTSLADSVHLQ-----TPLHMAIAYNHPDVVSVILEQKANA 569

Query: 138  NVATED-------------GFTPLAVALQQGHENVVAHLINYGTKGKVRL----PALHIA 180
              AT +               T L +AL  G   + A L+  G      +      LH+A
Sbjct: 570  LHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMA 629

Query: 181  ARNDDTRTAAVLLQNDPNPDV-LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
             +  D+++A  LL++  + +V  ++ G T L +A   +   V   +  RGA ++   + G
Sbjct: 630  IQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKG 689

Query: 240  ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE----LTPLHCAARNGHVRISEILLDHG 295
              PL +A       +   L+  G               T LH A    +   +  L+  G
Sbjct: 690  NPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSG 749

Query: 296  API------------QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLH 343
              +            + + ++G +P+H+AA     + V+ LL++ A ++    +  TP+H
Sbjct: 750  CDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIH 809

Query: 344  VAAHCGHHRVAKVLLD-KGAKPNSRALNGFTPLHIACK-KNHVRVMELLLKTGASIDAVT 401
            VA    H  + ++L+       N R   G TP   A   KN+     +L +   + + V 
Sbjct: 810  VAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVD 869

Query: 402  ESGLTPLHVASFMGHLPIVKNLLQRGASPN--VSNVKVETPLHMAARAGHTEVAKYLLQN 459
              G   LHVA     +  V  L+   A+ N  V +    TPLH+A +AG   + + LL  
Sbjct: 870  NKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLA 929

Query: 460  KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519
             AKVN   K  QT LH AA+     +  +LLEN  +       G+  LH+A   G +  +
Sbjct: 930  GAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNI 989

Query: 520  LALL-EKEASQACMTKKGFTPLHVAAKYGKVRVA---ELLLE-RDAHP-NAAGKNGLTPL 573
              LL E          +G +PLH+  +YGK   A   +L LE    +P +    +G T L
Sbjct: 990  RVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVL 1049

Query: 574  HVAVHHNNLDIVKLLLPRG 592
             +A    N ++ + ++  G
Sbjct: 1050 LLAYMKGNANLCRAIVRSG 1068



 Score =  145 bits (366), Expect = 4e-34
 Identities = 134/532 (25%), Positives = 232/532 (43%), Gaps = 35/532 (6%)

Query: 4    SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
            ++ +   D  +  L   +  N   A ++L+   D +  +      L LA   G   +  +
Sbjct: 550  AIAYNHPDVVSVILE--QKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQ 607

Query: 64   LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQEN 122
            LL     +  T   G T LH+A      +    L+ + A++N +++Q G T L +A +  
Sbjct: 608  LLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQ 667

Query: 123  HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------ 176
               VV  +   GA+ +V  E G  PL +AL    E++ + L+ +G       P       
Sbjct: 668  LPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQ 727

Query: 177  --LHIAARNDDTRTAAVLLQ-----NDPNP-------DVLSKTGFTPLHIAAHYENLNVA 222
              LH A   ++  TA  L++     N P         +  ++ G TPLH+AA +      
Sbjct: 728  TLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETV 787

Query: 223  QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR-GAQIETKTKDELTPLHCAAR 281
            Q LL  GA+VN     G TP+H+A    + ++++LL+      +  + +  LTP  CA  
Sbjct: 788  QCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMT 847

Query: 282  NGHVRISEILL--DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLD-- 337
              + + +E +L  + GA  Q   K G + +H+A Q   ++ V  L+   A ++    D  
Sbjct: 848  FKNNKSAEAILKRESGAAEQVDNK-GRNFLHVAVQNSDIESVLFLISVHANVNSRVQDAS 906

Query: 338  HLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI 397
             LTPLH+A   G   + + LL  GAK N    +  T LH+A +++   +  +LL+ G   
Sbjct: 907  KLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDF 966

Query: 398  DAVTESGLTPLHVASFMGHLPIVKNLL-QRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
             AV E+G   LH+A   G L  ++ LL +        N++ ++PLH+  + G    A   
Sbjct: 967  AAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIF 1026

Query: 457  -----LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503
                       ++    D  T L  A   G+ N+ + ++ + A   +    G
Sbjct: 1027 DLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQG 1078



 Score =  114 bits (285), Expect = 9e-25
 Identities = 95/360 (26%), Positives = 161/360 (44%), Gaps = 42/360 (11%)

Query: 80   TALHIAALAGQDEVVRELVNYGANVNAQSQKGF------------TPLYMAAQENHLEVV 127
            T LH A     +     L+  G +VN+  Q G             TPL++AA     E V
Sbjct: 728  TLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETV 787

Query: 128  KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187
            + LLE GAN N    +G TP+ VA+   H  ++  L+++        P +H+  R+    
Sbjct: 788  QCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSH--------PDIHLNVRDRQGL 839

Query: 188  T---AAVLLQNDPNPDVLSKT-----------GFTPLHIAAHYENLNVAQLLLNRGASVN 233
            T    A+  +N+ + + + K            G   LH+A    ++     L++  A+VN
Sbjct: 840  TPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVN 899

Query: 234  FTPQNG--ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
               Q+   +TPLH+A + G+ I+VR LL  GA++   TK   T LH AA+     I  +L
Sbjct: 900  SRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVL 959

Query: 292  LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLL-QYDAEIDDITLDHLTPLHVAAHCGH 350
            L++G    A  +NG + +H+A     L+ +R+LL +   + +   L   +PLH+    G 
Sbjct: 960  LENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGK 1019

Query: 351  HRVAKVL-----LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 405
               A +         G   +    +G T L +A  K +  +   ++++GA +      G+
Sbjct: 1020 ENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGV 1079


>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
           sapiens]
          Length = 1771

 Score =  196 bits (498), Expect = 2e-49
 Identities = 136/410 (33%), Positives = 204/410 (49%), Gaps = 9/410 (2%)

Query: 192 LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN 251
           LL+   + D  ++ G TPL IAA   NL + + L+  GA+ N    +  T L  AS+ G+
Sbjct: 24  LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGH 83

Query: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 311
           V +V  LL  G  +E +     T L  A   G   + E+LL HGA         + PI  
Sbjct: 84  VHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIW 143

Query: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371
           AA   H D V LLLQ  A+++       TPL  AA  GH    K LL  GA  +    N 
Sbjct: 144 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203

Query: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
            T L +A K  + + ++ +LK   +++   + G T L +AS  GH  IV++LL  G   N
Sbjct: 204 MTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVN 263

Query: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
           + +   +T L  A R GH E+ + LLQ  A ++ + +D++T L+ A   G+  MV+ +L+
Sbjct: 264 IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQ 323

Query: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
            N +  + T  G TPL  A +  ++E V  LL+K A  + + KKG TPLH+A +    ++
Sbjct: 324 CNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKL 383

Query: 552 AELLLERDA------HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
           AELLL           PN AG+   TP ++   H    + ++   R  SP
Sbjct: 384 AELLLRNPKDGRLLYRPNKAGE---TPYNIDCSHQKSILTQIFGARHLSP 430



 Score =  185 bits (469), Expect = 4e-46
 Identities = 130/395 (32%), Positives = 197/395 (49%), Gaps = 3/395 (0%)

Query: 217 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276
           EN+   + LL +   V+   + G TPL IA+ +GN+ +V+ L+  GA    +  D  T L
Sbjct: 16  ENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75

Query: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL 336
             A++ GHV I E LL  G  ++ +   G + +  A      D V LLL + A      L
Sbjct: 76  ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135

Query: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
             + P+  AA  GH  +  +LL  GAK N     G TPL  A +K H+  ++ LL  GA 
Sbjct: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195

Query: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
           +D    + +T L VA   G+   VK +L+R  + N+++    T L +A++ GHTE+ + L
Sbjct: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255

Query: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
           L     VN   +   T L  A R GH  +V+ LL+  A+ ++      T L+ A  +G+ 
Sbjct: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315

Query: 517 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576
             V  +L+        TK G TPL  A K   + V ELLL++ A  +A  K G TPLH+A
Sbjct: 316 TMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375

Query: 577 VHHNNLDIVKLLL--PRGGS-PHSPAWNGYTPLHI 608
           +   +  + +LLL  P+ G   + P   G TP +I
Sbjct: 376 IRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNI 410



 Score =  182 bits (463), Expect = 2e-45
 Identities = 130/387 (33%), Positives = 192/387 (49%), Gaps = 3/387 (0%)

Query: 291 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGH 350
           LL+    +  + + G +P+ +AA+  +L+ V+ L++  A  +   LD+ T L  A+  GH
Sbjct: 24  LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGH 83

Query: 351 HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV 410
             + + LL  G     R + G+T L  AC K    V+ELLL  GA+        + P+  
Sbjct: 84  VHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIW 143

Query: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470
           A+  GH  IV  LLQ GA  N S+    TPL  AAR GH E  K+LL   A V+ +  + 
Sbjct: 144 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203

Query: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530
            T L  A + G+T  VK +L+ N N NL    G+T L IA++EGH E V  LL+      
Sbjct: 204 MTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVN 263

Query: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590
              + G T L  A + G V +   LL++ A  +  G++  T L+ AV   N  +V+ +L 
Sbjct: 264 IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQ 323

Query: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
                     +G TPL  A K   +EV   LL  G   +A   +G TPLH+A +    ++
Sbjct: 324 CNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKL 383

Query: 651 VALLLSKQANGNL---GNKSGLTPLHL 674
             LLL    +G L    NK+G TP ++
Sbjct: 384 AELLLRNPKDGRLLYRPNKAGETPYNI 410



 Score =  178 bits (451), Expect = 5e-44
 Identities = 126/412 (30%), Positives = 206/412 (50%), Gaps = 4/412 (0%)

Query: 316 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL 375
           +++  ++ LL+   ++D+      TPL +AA  G+  + K L+  GA  N   L+ +T L
Sbjct: 16  ENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75

Query: 376 HIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNV 435
             A K+ HV ++E LLK G +++     G T L  A + G   +V+ LL  GA+P+V+ +
Sbjct: 76  ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135

Query: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495
               P+  AA  GH ++   LLQN AKVN   K   TPL  AAR GH   VK LL   A+
Sbjct: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195

Query: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555
            +       T L +A + G+ ++V  +L++  +     K G T L +A+K G   + + L
Sbjct: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255

Query: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615
           L+   + N   ++G T L  AV   +++IV+ LL +         +  T L+ A ++   
Sbjct: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315

Query: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675
            + R +LQ        +  G TPL  A +  + E+V LLL K A  +  +K G TPLH+ 
Sbjct: 316 TMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375

Query: 676 AQEGHVPVADVLI---KHGVMVDATTRMGYTPLHV-ASHYGNIKLVKFLLQH 723
            +     +A++L+   K G ++    + G TP ++  SH  +I    F  +H
Sbjct: 376 IRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARH 427



 Score =  172 bits (437), Expect = 2e-42
 Identities = 119/377 (31%), Positives = 190/377 (50%)

Query: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439
           ++ ++  ++ LL+    +D   E G TPL +A+  G+L IVK L++ GA+ N+ ++   T
Sbjct: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73

Query: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 499
            L  A++ GH  + + LL+    +  +     T L  A   G T++V+LLL + ANP++ 
Sbjct: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133

Query: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 559
                 P+  AA  GH + V  LL+  A   C  K G TPL  AA+ G +   + LL   
Sbjct: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193

Query: 560 AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR 619
           A  +  G N +T L VAV       VK +L R  + +    +G T L IA+K+   E+ +
Sbjct: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253

Query: 620 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEG 679
            LL  G   N     G T L  A + GH E+V  LL K A+ ++  +   T L+   ++G
Sbjct: 254 DLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKG 313

Query: 680 HVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLH 739
           +  +   +++     +  T+ G TPL  A+   NI++V+ LL   A V+A  K G +PLH
Sbjct: 314 NATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLH 373

Query: 740 QAAQQGHTDIVTLLLKN 756
            A +     +  LLL+N
Sbjct: 374 IAIRGRSRKLAELLLRN 390



 Score =  172 bits (437), Expect = 2e-42
 Identities = 126/419 (30%), Positives = 204/419 (48%), Gaps = 32/419 (7%)

Query: 94  VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQ 153
           ++ L+    +V+ +++ G TPL +AA++ +LE+VK L++NGAN N+   D +T L  A +
Sbjct: 21  LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80

Query: 154 QGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 213
           +GH ++V  L+  G                              N +     G+T L  A
Sbjct: 81  EGHVHIVEELLKCGV-----------------------------NLEHRDMGGWTALMWA 111

Query: 214 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 273
            +    +V +LLL+ GA+ + T    + P+  A+ RG+  +V LLL  GA++    K   
Sbjct: 112 CYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGT 171

Query: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
           TPL  AAR GH+   + LL  GA +  +  N ++ + +A +G +   V+ +L+ +  ++ 
Sbjct: 172 TPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNL 231

Query: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
              D  T L +A+  GH  + + LLD G   N    +G T L  A +  HV ++  LL+ 
Sbjct: 232 TDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQK 291

Query: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 453
            A ID   +   T L+ A   G+  +V+++LQ      +     ETPL  A +  + EV 
Sbjct: 292 YADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVV 351

Query: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL---ATTAGHTPLHI 509
           + LL   AKV+A  K   TPLH A R     + +LLL N  +  L      AG TP +I
Sbjct: 352 ELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNI 410



 Score =  172 bits (435), Expect = 4e-42
 Identities = 121/376 (32%), Positives = 191/376 (50%), Gaps = 13/376 (3%)

Query: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
           T  + AA  GNL+   + ++NG + N  + +    L  ASKEGHV +V ELL   + LE 
Sbjct: 40  TPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEH 99

Query: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
               G TAL  A   G+ +VV  L+++GAN +        P+  AA   H ++V  LL+N
Sbjct: 100 RDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQN 159

Query: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTA 189
           GA  N + + G TPL  A ++GH   V HL+  G     +G   + AL +A +   T++ 
Sbjct: 160 GAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSV 219

Query: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
             +L+ +PN ++  K G T L IA+   +  + Q LL+ G  VN   ++G T L  A R 
Sbjct: 220 KEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRG 279

Query: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309
           G+V +VR LL + A I+ + +D  T L+ A   G+  +   +L      +  TK+G +P+
Sbjct: 280 GHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPL 339

Query: 310 HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA------K 363
             A +  +++ V LLL   A++  +     TPLH+A      ++A++LL          +
Sbjct: 340 IKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYR 399

Query: 364 PNSRALNGFTPLHIAC 379
           PN     G TP +I C
Sbjct: 400 PNKA---GETPYNIDC 412



 Score =  166 bits (419), Expect = 3e-40
 Identities = 127/415 (30%), Positives = 198/415 (47%), Gaps = 3/415 (0%)

Query: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414
           K LL+K    + R   G TPL IA ++ ++ +++ L+K GA+ +       T L  AS  
Sbjct: 22  KALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKE 81

Query: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474
           GH+ IV+ LL+ G +    ++   T L  A   G T+V + LL + A  +        P+
Sbjct: 82  GHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPI 141

Query: 475 HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK 534
             AA  GH ++V LLL+N A  N +   G TPL  AAR+GH+E V  LL   A       
Sbjct: 142 IWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGA 201

Query: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
              T L VA K G  +  + +L+R+ + N   K+G T L +A    + +IV+ LL  G  
Sbjct: 202 NSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTY 261

Query: 595 PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
            + P  +G T L  A +   VE+ R+LLQ     +       T L+ A ++G+A MV  +
Sbjct: 262 VNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDI 321

Query: 655 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNI 714
           L    +  +  K G TPL    +  ++ V ++L+  G  V A  + G TPLH+A    + 
Sbjct: 322 LQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSR 381

Query: 715 KLVKFLLQHQAD---VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766
           KL + LL++  D   +    K G +P +       + +  +      SP E   D
Sbjct: 382 KLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGD 436



 Score =  161 bits (408), Expect = 5e-39
 Identities = 118/363 (32%), Positives = 179/363 (49%), Gaps = 6/363 (1%)

Query: 54  KEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFT 113
           +E ++  +  LL K   ++   + G T L IAA  G  E+V+EL+  GAN N +    +T
Sbjct: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73

Query: 114 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173
            L  A++E H+ +V+ LL+ G N       G+T L  A  +G  +VV  L+++G    V 
Sbjct: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133

Query: 174 -----LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228
                 P +  A R        +LLQN    +   K G TPL  AA   +L   + LL  
Sbjct: 134 GLYSVYPIIWAAGRG-HADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAM 192

Query: 229 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
           GA V+    N +T L +A + G    V+ +L R   +    KD  T L  A++ GH  I 
Sbjct: 193 GADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIV 252

Query: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348
           + LLD G  +    ++G + +  A +G H++ VR LLQ  A+ID    D+ T L+ A   
Sbjct: 253 QDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEK 312

Query: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
           G+  + + +L           +G TPL  A K  ++ V+ELLL  GA + AV + G TPL
Sbjct: 313 GNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPL 372

Query: 409 HVA 411
           H+A
Sbjct: 373 HIA 375



 Score =  161 bits (408), Expect = 5e-39
 Identities = 114/361 (31%), Positives = 174/361 (48%)

Query: 416 HLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH 475
           ++P +K LL++    +  N   +TPL +AA  G+ E+ K L++N A  N +  D+ T L 
Sbjct: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76

Query: 476 CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK 535
            A++ GH ++V+ LL+   N       G T L  A  +G  + V  LL   A+ +     
Sbjct: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136

Query: 536 GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
              P+  AA  G   +  LLL+  A  N + K G TPL  A    +L+ VK LL  G   
Sbjct: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196

Query: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
                N  T L +A K    +  + +L+   + N     G T L +A++EGH E+V  LL
Sbjct: 197 DQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLL 256

Query: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
                 N+ ++SG T L    + GHV +   L++    +D   +   T L+ A   GN  
Sbjct: 257 DAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNAT 316

Query: 716 LVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
           +V+ +LQ   D    TK G +PL +A +  + ++V LLL  GA  + V   G TPL IA 
Sbjct: 317 MVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAI 376

Query: 776 R 776
           R
Sbjct: 377 R 377



 Score =  160 bits (404), Expect = 1e-38
 Identities = 124/447 (27%), Positives = 201/447 (44%), Gaps = 34/447 (7%)

Query: 120 QENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHI 179
           +E ++  +K LLE   + +   E G TPL +A +QG+  +V  LI               
Sbjct: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELI--------------- 58

Query: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
                         +N  N ++     +T L  A+   ++++ + LL  G ++      G
Sbjct: 59  --------------KNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG 104

Query: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
            T L  A  +G   +V LLL  GA         + P+  AA  GH  I  +LL +GA + 
Sbjct: 105 WTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVN 164

Query: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
              K G +P+  AA+  HL+CV+ LL   A++D    + +T L VA   G+ +  K +L 
Sbjct: 165 CSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILK 224

Query: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
           +    N    +G T L IA K+ H  +++ LL  G  ++    SG T L  A   GH+ I
Sbjct: 225 RNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEI 284

Query: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
           V+ LLQ+ A  ++     +T L+ A   G+  + + +LQ         KD +TPL  A +
Sbjct: 285 VRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATK 344

Query: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM----TKK 535
           + +  +V+LLL+  A  +     G TPLHIA R G    +  LL +      +     K 
Sbjct: 345 MRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIR-GRSRKLAELLLRNPKDGRLLYRPNKA 403

Query: 536 GFTPLHVAAKYGKVRVAELLLERDAHP 562
           G TP ++   + K  + ++   R   P
Sbjct: 404 GETPYNIDCSHQKSILTQIFGARHLSP 430



 Score =  159 bits (401), Expect = 3e-38
 Identities = 107/333 (32%), Positives = 168/333 (50%)

Query: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAARE 513
           K LL+    V+ + +  QTPL  AA  G+  +VK L++N AN NL      T L  A++E
Sbjct: 22  KALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKE 81

Query: 514 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 573
           GHV  V  LL+   +       G+T L  A   G+  V ELLL   A+P+  G   + P+
Sbjct: 82  GHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPI 141

Query: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 633
             A    + DIV LLL  G   +     G TPL  AA++  +E  + LL  G   + E  
Sbjct: 142 IWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGA 201

Query: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693
             +T L +A + G+ + V  +L +  N NL +K G T L + ++EGH  +   L+  G  
Sbjct: 202 NSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTY 261

Query: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
           V+   R G T L  A   G++++V+ LLQ  AD++ + +   + L+ A ++G+  +V  +
Sbjct: 262 VNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDI 321

Query: 754 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
           L+        + DG TPL  A ++  I V ++L
Sbjct: 322 LQCNPDTEICTKDGETPLIKATKMRNIEVVELL 354



 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 59/170 (34%), Positives = 92/170 (54%)

Query: 611 KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLT 670
           ++  +   ++LL+     +  +  G TPL +AA++G+ E+V  L+   AN NL +    T
Sbjct: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73

Query: 671 PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 730
            L   ++EGHV + + L+K GV ++     G+T L  A + G   +V+ LL H A+ +  
Sbjct: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133

Query: 731 TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780
                 P+  AA +GH DIV LLL+NGA  N     GTTPL  A R G++
Sbjct: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHL 183



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 63/222 (28%), Positives = 113/222 (50%), Gaps = 7/222 (3%)

Query: 10  ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI 69
           A++ T+ + A + G      + L+   ++N  +++G   L +ASKEGH ++V +LL    
Sbjct: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260

Query: 70  ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129
            +    + G+T L  A   G  E+VR L+   A+++ + Q   T LY A ++ +  +V+ 
Sbjct: 261 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 320

Query: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDD 185
           +L+   +  + T+DG TPL  A +  +  VV  L++ G K     K     LHIA R   
Sbjct: 321 ILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRS 380

Query: 186 TRTAAVLLQNDPNPDVL---SKTGFTPLHIAAHYENLNVAQL 224
            + A +LL+N  +  +L   +K G TP +I   ++   + Q+
Sbjct: 381 RKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQI 422



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 50/189 (26%), Positives = 91/189 (48%), Gaps = 12/189 (6%)

Query: 644 QEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYT 703
           +E +   +  LL K  + +  N+ G TPL + A++G++ +   LIK+G   +      +T
Sbjct: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73

Query: 704 PLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEV 763
            L  AS  G++ +V+ LL+   ++  +   G++ L  A  +G TD+V LLL +GA+P+  
Sbjct: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133

Query: 764 SSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKH---------RMSFPETVDEIL 814
                 P+  A   G+    D++ ++    + V  SDK+         R    E V  +L
Sbjct: 134 GLYSVYPIIWAAGRGH---ADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLL 190

Query: 815 DVSEDEGEE 823
            +  D  +E
Sbjct: 191 AMGADVDQE 199



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 39/129 (30%), Positives = 63/129 (48%)

Query: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
           V   +    T  + A R G+++     L+   DI+   Q+    L+ A ++G+  MV ++
Sbjct: 262 VNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDI 321

Query: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
           L      E  TK G T L  A      EVV  L++ GA V+A  +KG TPL++A +    
Sbjct: 322 LQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSR 381

Query: 125 EVVKFLLEN 133
           ++ + LL N
Sbjct: 382 KLAELLLRN 390


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  191 bits (486), Expect = 4e-48
 Identities = 121/334 (36%), Positives = 177/334 (52%), Gaps = 5/334 (1%)

Query: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
           LH+A        A  LL N+ NP++ ++ G TPLH+A       V +LLL R  SVN   
Sbjct: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501

Query: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296
           ++  T LH A++ G+    RLLL++ A +     +  TP+H A ++G   I  ILL  G 
Sbjct: 502 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGV 561

Query: 297 PIQAKTKNGLSPIHMAAQGDHLDCVRLLL-QYDAEIDDITLDHLTPLHVAAHCGHHRVAK 355
            +  + K+   P+H AA   HL  V+LL  Q    ++  TLD  TPLH+AA  GH+RVA+
Sbjct: 562 DVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVAR 621

Query: 356 VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMG 415
           +L+D  +  N  +L   TPLH+A +  H     LLL  GA  +A+T  G T LH+A+  G
Sbjct: 622 ILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNG 681

Query: 416 HLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH 475
           HL  VK L++  A         +T LH+AA  GH+EV + L+     ++   +   + LH
Sbjct: 682 HLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALH 740

Query: 476 CAARIGHTNMVKLLLENNANPNLAT---TAGHTP 506
            AA+  H   V+ LL + A+ NL +     GH P
Sbjct: 741 LAAQGRHAQTVETLLRHGAHINLQSLKFQGGHGP 774



 Score =  186 bits (471), Expect = 2e-46
 Identities = 122/361 (33%), Positives = 178/361 (49%), Gaps = 10/361 (2%)

Query: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
           +D   +SG + LH+A   G     K LL   A+PN+SN +  TPLHMA       V + L
Sbjct: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490

Query: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
           L  K  VNAK +D  T LH AA+ G  +  +LLLE NA+ N     G TP+H+A + G  
Sbjct: 491 LARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQE 550

Query: 517 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER-DAHPNAAGKNGLTPLHV 575
             V  LL +    +   K  + PLH AA  G + + +LL ++     NA   +G TPLH+
Sbjct: 551 NIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHL 610

Query: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
           A    +  + ++L+      +  +    TPLH+AA+      AR LL  G    A +  G
Sbjct: 611 AAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDG 670

Query: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
            T LHLAA+ GH   V LL+ ++A+         T LHL A  GH  V + L+   V +D
Sbjct: 671 YTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-ID 729

Query: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755
                G + LH+A+   + + V+ LL+H A +N ++           Q GH    TLL +
Sbjct: 730 LFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQS--------LKFQGGHGPAATLLRR 781

Query: 756 N 756
           +
Sbjct: 782 S 782



 Score =  184 bits (466), Expect = 9e-46
 Identities = 116/322 (36%), Positives = 166/322 (51%), Gaps = 2/322 (0%)

Query: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
           LH+A  AG  E AK+LL N A  N   +   TPLH A       +V+LLL    + N   
Sbjct: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501

Query: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560
               T LH AA+ G   +   LLEK AS   +  +G TP+HVA ++G+  +  +LL R  
Sbjct: 502 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGV 561

Query: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG-SPHSPAWNGYTPLHIAAKQNQVEVAR 619
             +  GK+   PLH A    +L IVKLL  + G S ++   +G TPLH+AA++    VAR
Sbjct: 562 DVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVAR 621

Query: 620 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEG 679
            L+      N  S+   TPLH+AA+ GH     LLL + A        G T LHL A+ G
Sbjct: 622 ILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNG 681

Query: 680 HVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLH 739
           H+    +L++    V A   +  T LH+A+ +G+ ++V+ L+     ++   + G S LH
Sbjct: 682 HLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALH 740

Query: 740 QAAQQGHTDIVTLLLKNGASPN 761
            AAQ  H   V  LL++GA  N
Sbjct: 741 LAAQGRHAQTVETLLRHGAHIN 762



 Score =  182 bits (461), Expect = 3e-45
 Identities = 110/333 (33%), Positives = 168/333 (50%), Gaps = 2/333 (0%)

Query: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
           V+    +G + LH+A   G     + LL   A      +   TPLH A       + E+L
Sbjct: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490

Query: 292 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH 351
           L     + AK ++  + +H AAQ       RLLL+ +A ++++  +  TP+HVA   G  
Sbjct: 491 LARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQE 550

Query: 352 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT-GASIDAVTESGLTPLHV 410
            + ++LL +G   + +  + + PLH A  + H+ +++LL K  G S++A T  G TPLH+
Sbjct: 551 NIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHL 610

Query: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470
           A+  GH  + + L+   +  NV ++  +TPLH+AA  GHT  A+ LL   A   A   D 
Sbjct: 611 AAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDG 670

Query: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530
            T LH AAR GH   VKLL+E  A+         T LH+AA  GH E V  L+  +    
Sbjct: 671 YTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVID- 729

Query: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
              ++G + LH+AA+    +  E LL   AH N
Sbjct: 730 LFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762



 Score =  181 bits (458), Expect = 8e-45
 Identities = 119/344 (34%), Positives = 179/344 (52%), Gaps = 3/344 (0%)

Query: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
           DT     +LQ   + D+   +G + LH+A        A+ LL   A+ N + + G TPLH
Sbjct: 418 DTSKLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLH 476

Query: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
           +A  R    +V LLL R   +  K +D+ T LH AA+NG    + +LL+  A +      
Sbjct: 477 MAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFE 536

Query: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK-GAK 363
           G +P+H+A Q    + VR+LL+   ++     D   PLH AA  GH  + K+L  + G  
Sbjct: 537 GRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVS 596

Query: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
            N++ L+G TPLH+A ++ H RV  +L+   + ++  +    TPLHVA+  GH    + L
Sbjct: 597 VNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLL 656

Query: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
           L RGA          T LH+AAR GH    K L++ KA V A+   +QT LH AA  GH+
Sbjct: 657 LHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHS 716

Query: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527
            +V+ L+  +   +L    G + LH+AA+  H +TV  LL   A
Sbjct: 717 EVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759



 Score =  169 bits (429), Expect = 2e-41
 Identities = 105/318 (33%), Positives = 171/318 (53%), Gaps = 18/318 (5%)

Query: 536 GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
           G + LH+A + G+   A+ LL  +A+PN + + G TPLH+AV      +V+LLL R  S 
Sbjct: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 497

Query: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
           ++   + +T LH AA+       R LL+   S N    +G TP+H+A Q G   +V +LL
Sbjct: 498 NAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILL 557

Query: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH-GVMVDATTRMGYTPLHVASHYGNI 714
            +  + +L  K    PLH  A +GH+P+  +L K  GV V+A T  G TPLH+A+  G+ 
Sbjct: 558 RRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHY 617

Query: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
           ++ + L+   +DVN  + L  +PLH AA+ GHT    LLL  GA    ++SDG T L +A
Sbjct: 618 RVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLA 677

Query: 775 KRLGYISVTDVLKVVTDETSFVL-------------VSDKHRMSFPETVD-EILDVSEDE 820
            R G+++    +K++ +E + VL              +  H     E V  +++D+ +++
Sbjct: 678 ARNGHLA---TVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVIDLFDEQ 734

Query: 821 GEELISFKAERRDSRDVD 838
           G   +   A+ R ++ V+
Sbjct: 735 GLSALHLAAQGRHAQTVE 752



 Score =  155 bits (393), Expect = 3e-37
 Identities = 118/354 (33%), Positives = 175/354 (49%), Gaps = 9/354 (2%)

Query: 22  SGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTA 81
           SG+  K +  L+   D++    +G + LHLA + G  +    LL        + ++G+T 
Sbjct: 416 SGDTSKLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTP 474

Query: 82  LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
           LH+A       VV  L+    +VNA+ +  +T L+ AAQ       + LLE  A+ N   
Sbjct: 475 LHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVD 534

Query: 142 EDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTAAVLLQNDP 197
            +G TP+ VA Q G EN+V  L+  G     +GK     LH AA          LL   P
Sbjct: 535 FEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHL-PIVKLLAKQP 593

Query: 198 NPDVLSKT--GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV 255
              V ++T  G TPLH+AA   +  VA++L++  + VN       TPLH+A+  G+    
Sbjct: 594 GVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTA 653

Query: 256 RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315
           RLLL RGA  E  T D  T LH AARNGH+   ++L++  A + A+     + +H+AA  
Sbjct: 654 RLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAH 713

Query: 316 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369
            H + V  L+  D  ID      L+ LH+AA   H +  + LL  GA  N ++L
Sbjct: 714 GHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSL 766



 Score =  152 bits (383), Expect = 4e-36
 Identities = 109/329 (33%), Positives = 168/329 (51%), Gaps = 9/329 (2%)

Query: 11  DAATSFLR-AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL-HKE 68
           D+  S L  A  +G  + A   L N  + N  N+ G   LH+A  E  V+ VVELL  ++
Sbjct: 436 DSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAV-ERRVRGVVELLLARK 494

Query: 69  IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
           I +    +   TALH AA  G +   R L+   A+VN    +G TP+++A Q     +V+
Sbjct: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554

Query: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHL-----INYGTKGKVRLPALHIAARN 183
            LL  G + ++  +D + PL  A  QGH  +V  L     ++   +       LH+AA+ 
Sbjct: 555 ILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQR 614

Query: 184 DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPL 243
              R A +L+    + +V S    TPLH+AA   + + A+LLL+RGA       +G T L
Sbjct: 615 GHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTAL 674

Query: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
           H+A+R G++  V+LL++  A +  +     T LH AA +GH  + E L+     I    +
Sbjct: 675 HLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDE 733

Query: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
            GLS +H+AAQG H   V  LL++ A I+
Sbjct: 734 QGLSALHLAAQGRHAQTVETLLRHGAHIN 762



 Score =  104 bits (259), Expect = 9e-22
 Identities = 78/272 (28%), Positives = 132/272 (48%), Gaps = 8/272 (2%)

Query: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
           SV  ++ D  T+   AA++G+       L     +N  +  G   +H+A + G   +V  
Sbjct: 496 SVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRI 555

Query: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNY-GANVNAQSQKGFTPLYMAAQEN 122
           LL + + +    K     LH AA  G   +V+ L    G +VNAQ+  G TPL++AAQ  
Sbjct: 556 LLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRG 615

Query: 123 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRL-----PAL 177
           H  V + L++  ++ NV +    TPL VA + GH +    L++ G  GK  +      AL
Sbjct: 616 HYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGA-GKEAMTSDGYTAL 674

Query: 178 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ 237
           H+AARN    T  +L++   +         T LH+AA + +  V + L++    ++   +
Sbjct: 675 HLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDE 733

Query: 238 NGITPLHIASRRGNVIMVRLLLDRGAQIETKT 269
            G++ LH+A++  +   V  LL  GA I  ++
Sbjct: 734 QGLSALHLAAQGRHAQTVETLLRHGAHINLQS 765



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 43/125 (34%), Positives = 65/125 (52%)

Query: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721
           +L   SG + LHL  + G    A  L+ +    + + R G TPLH+A       +V+ LL
Sbjct: 432 DLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLL 491

Query: 722 QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYIS 781
             +  VNAK +  ++ LH AAQ G      LLL+  AS NEV  +G TP+ +A + G  +
Sbjct: 492 ARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQEN 551

Query: 782 VTDVL 786
           +  +L
Sbjct: 552 IVRIL 556



 Score = 52.0 bits (123), Expect = 5e-06
 Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 1/101 (0%)

Query: 10  ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI 69
           +D  T+   AAR+G+L      +    D+          LHLA+  GH ++V EL+  ++
Sbjct: 668 SDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV 727

Query: 70  ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 110
           I +   ++G +ALH+AA     + V  L+ +GA++N QS K
Sbjct: 728 I-DLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLK 767



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 31/93 (33%), Positives = 44/93 (47%)

Query: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
           VD     G + LH+A   G  +  K+LL + A+ N   + G +PLH A ++    +V LL
Sbjct: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490

Query: 754 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
           L    S N    D  T L  A + G  S T +L
Sbjct: 491 LARKISVNAKDEDQWTALHFAAQNGDESSTRLL 523



 Score = 36.6 bits (83), Expect = 0.23
 Identities = 27/72 (37%), Positives = 38/72 (52%), Gaps = 2/72 (2%)

Query: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
           KL+K +LQ Q DV+     G S LH A + G  +    LL N A+PN  +  G+TPL +A
Sbjct: 421 KLMK-ILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMA 478

Query: 775 KRLGYISVTDVL 786
                  V ++L
Sbjct: 479 VERRVRGVVELL 490


>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
          Length = 1119

 Score =  187 bits (476), Expect = 6e-47
 Identities = 152/536 (28%), Positives = 253/536 (47%), Gaps = 30/536 (5%)

Query: 82  LHIAALAGQDEVVRELVNYGAN--VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
           LH AA  GQ E++ ++    +   ++     G TPL+ A ++N +E VKFLL  GAN N+
Sbjct: 67  LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126

Query: 140 ATEDGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRTAAVLLQ 194
              +   PL +A+Q  +  V+  L+ + T     +G+    A+ IA   +++    +LL+
Sbjct: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186

Query: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS--------VNFTPQNGITPLHIA 246
               P   +K G  P+H AA   +    +++L  G          +NF      TPLH+A
Sbjct: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246

Query: 247 SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD--HGAPIQAKTKN 304
            + G++ M+++ LD GAQI+   K   T +H AA  G   I ++++    G+     T +
Sbjct: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306

Query: 305 GL--SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
           G   + +H A+  DH +    L+   A+I+ I  +  +PL +A       +  +LL KGA
Sbjct: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366

Query: 363 KPNSRALNGFTPLHIACK-----KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHL 417
           + + +   G   LH+  +     KN       + +    +      G TPLH A   G  
Sbjct: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGP 426

Query: 418 PIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD---QTPL 474
             V NLL    S +  +   ++PLH AA  G     + LLQ+ +      + D    TPL
Sbjct: 427 GSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPL 486

Query: 475 HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMT 533
           H AA+ GH  +V+LLL+  A   L+   G T LH A+  G+ +T+  +L+        + 
Sbjct: 487 HLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLD 545

Query: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
           + G T LH AA+ G  +   LLL  +A      K   + LH+A+H+   ++V  ++
Sbjct: 546 EDGNTALHFAAREGHAKAVALLLSHNA-DIVLNKQQASFLHLALHNKRKEVVLTII 600



 Score =  180 bits (457), Expect = 1e-44
 Identities = 155/547 (28%), Positives = 243/547 (44%), Gaps = 44/547 (8%)

Query: 243 LHIASRRGNV-IMVRLLLDRGAQIETKTKDE-LTPLHCAARNGHVRISEILLDHGAPIQA 300
           LH A+  G + +M ++  D   ++  +  D   TPLHCA     +   + LL  GA    
Sbjct: 67  LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126

Query: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHHRVAKVL 357
           +  N ++P+H+A QG + + +++LL++     D+ L+     T + +A    +    ++L
Sbjct: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEH--RTIDVNLEGENGNTAVIIACTTNNSEALQIL 184

Query: 358 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS--------IDAVTESGLTPLH 409
           L KGAKP      G  P+H A        ME++L+ G          I+ +     TPLH
Sbjct: 185 LKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLH 244

Query: 410 VASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK----VNA 465
           +A   G L ++K  L  GA  +       T +H AA  G TE+ K ++ + +     VN 
Sbjct: 245 LAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNT 304

Query: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525
                +T LH A+   H  +   L+   A+ N   + G +PL +A        V  LL K
Sbjct: 305 TDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSK 364

Query: 526 EASQACMTKKGFTPLHVAAK--YG----------KVRVAELLLERDAHPNAAGKNGLTPL 573
            A        G   LH+  +  YG            ++ EL+++ D        +G TPL
Sbjct: 365 GAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDED-------NDGCTPL 417

Query: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA---NA 630
           H A        V  LL    S HS + +  +PLH AA   ++   + LLQ        N 
Sbjct: 418 HYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNE 477

Query: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
             + G+TPLHLAA+ GH ++V LLL K A   L + +G T LH  +  G+     V++  
Sbjct: 478 GDLHGMTPLHLAAKNGHDKVVQLLLKKGALF-LSDHNGWTALHHASMGGYTQTMKVILDT 536

Query: 691 GVM-VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
            +   D     G T LH A+  G+ K V  LL H AD+    K   S LH A      ++
Sbjct: 537 NLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALHNKRKEV 595

Query: 750 VTLLLKN 756
           V  ++++
Sbjct: 596 VLTIIRS 602



 Score =  174 bits (441), Expect = 7e-43
 Identities = 152/518 (29%), Positives = 235/518 (45%), Gaps = 47/518 (9%)

Query: 276 LHCAARNGHVRISE-ILLDHGAPIQAKTKN-GLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
           LH AA  G + + E I  D    +  +  + G +P+H A + + ++ V+ LL   A  + 
Sbjct: 67  LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126

Query: 334 ITLDHLTPLHVAAHCGHHRVAKVLLD-KGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392
              + + PLH+A    ++ V KVLL+ +    N    NG T + IAC  N+   +++LLK
Sbjct: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186

Query: 393 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP--------NVSNVKVETPLHMA 444
            GA      + G  P+H A+F G    ++ +L+ G           N  N    TPLH+A
Sbjct: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246

Query: 445 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP----NLAT 500
            + G  E+ K  L N A+++   K   T +H AA  G T +VKL++ + +      N   
Sbjct: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306

Query: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560
               T LH A+   H E    L+   A    +  +G +PL +A       +  LLL + A
Sbjct: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366

Query: 561 HPNAAGKNGLTPLHVAVHH----NNL--------DIVKLLLPRGGSPHSPAWNGYTPLHI 608
             +     G   LH+ V       NL         I +L++           +G TPLH 
Sbjct: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDN-------DGCTPLHY 419

Query: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL---GN 665
           A +Q       +LL +  S +++S    +PLH AA  G       LL   ++  L   G+
Sbjct: 420 ACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGD 479

Query: 666 KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
             G+TPLHL A+ GH  V  +L+K G +   +   G+T LH AS  G  + +K +L    
Sbjct: 480 LHGMTPLHLAAKNGHDKVVQLLLKKGALF-LSDHNGWTALHHASMGGYTQTMKVIL---- 534

Query: 726 DVNAKT-----KLGYSPLHQAAQQGHTDIVTLLLKNGA 758
           D N K      + G + LH AA++GH   V LLL + A
Sbjct: 535 DTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNA 572



 Score =  174 bits (440), Expect = 9e-43
 Identities = 151/509 (29%), Positives = 234/509 (45%), Gaps = 30/509 (5%)

Query: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD-RGAQ 264
           G TPLH A     +   + LL+RGA+ N    N + PLHIA +  N  ++++LL+ R   
Sbjct: 98  GNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTID 157

Query: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
           +  + ++  T +  A    +    +ILL  GA      K G  PIH AA     +C+ ++
Sbjct: 158 VNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEII 217

Query: 325 LQYDAE--------IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376
           L++  E        I+ +     TPLH+A   G   + K+ LD GA+ +       T +H
Sbjct: 218 LRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIH 277

Query: 377 IACKKNHVRVMELLLKT-GASIDAV-TESGL--TPLHVASFMGHLPIVKNLLQRGASPNV 432
            A  +    +++L++ +   S+D V T  G   T LH AS   H  +   L+  GA  N 
Sbjct: 278 FAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINK 337

Query: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR--IGHTNMVKLLL 490
            + +  +PL +A  +    +   LL   A+V+ K    +  LH   +   G  N+    +
Sbjct: 338 IDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFM 397

Query: 491 ENNANPNLATTA---GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 547
           +      L       G TPLH A R+G   +V  LL    S    +K   +PLH AA YG
Sbjct: 398 QMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYG 457

Query: 548 KVRVAELLLERDAHP---NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG---SPHSPAWN 601
           ++   + LL+  +     N    +G+TPLH+A  + +  +V+LLL +G    S H    N
Sbjct: 458 RINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDH----N 513

Query: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAE-SVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
           G+T LH A+     +  + +L             G T LH AA+EGHA+ VALLLS  A+
Sbjct: 514 GWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNAD 573

Query: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
             L NK   + LHL        V   +I+
Sbjct: 574 IVL-NKQQASFLHLALHNKRKEVVLTIIR 601



 Score =  149 bits (377), Expect = 2e-35
 Identities = 133/473 (28%), Positives = 208/473 (43%), Gaps = 60/473 (12%)

Query: 375 LHIACKKNHVRVMELLLKTGAS--IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
           LH A  +  + +ME + +  +   +  + + G TPLH A     +  VK LL RGA+PN+
Sbjct: 67  LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126

Query: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKA-KVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
            N  +  PLH+A +  + EV K LL+++   VN + ++  T +  A    ++  +++LL+
Sbjct: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186

Query: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALL--------EKEASQACMTKKGFTPLHVA 543
             A P  +   G  P+H AA  G  E +  +L         ++     M     TPLH+A
Sbjct: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246

Query: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP--RGGSPHSPAWN 601
            + G + + ++ L+  A  +   K   T +H A      +IVKL++    G        +
Sbjct: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306

Query: 602 G--YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
           G   T LH A+  +  E+A  L+  G   N    +G +PL LA       +V LLLSK A
Sbjct: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366

Query: 660 ----NGNLG----------------------------------NKSGLTPLHLVAQEGHV 681
                 N G                                  +  G TPLH   ++G  
Sbjct: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGP 426

Query: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD---VNAKTKLGYSPL 738
              + L+   V + + ++   +PLH A+ YG I   + LLQ  +D   +N     G +PL
Sbjct: 427 GSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPL 486

Query: 739 HQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTD 791
           H AA+ GH  +V LLLK GA       +G T L  A   GY   T  +KV+ D
Sbjct: 487 HLAAKNGHDKVVQLLLKKGALFLS-DHNGWTALHHASMGGY---TQTMKVILD 535



 Score =  141 bits (356), Expect = 5e-33
 Identities = 127/450 (28%), Positives = 207/450 (46%), Gaps = 27/450 (6%)

Query: 36  VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
           +D+N   +NG   + +A    + + +  LL K      + K G   +H AA +G  E + 
Sbjct: 156 IDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECME 215

Query: 96  ELVNYG--------ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 147
            ++ +G         ++N  +    TPL++A Q   LE++K  L+NGA  +   +   T 
Sbjct: 216 IILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTA 275

Query: 148 LAVALQQGHENVVAHLIN--------YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
           +  A  QG   +V  +I+          T        LH A+  D    A  L+    + 
Sbjct: 276 IHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADI 335

Query: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG-NVIMVRLL 258
           + +   G +PL +A    + N+  LLL++GA V+     G   LH+  ++   +  +R  
Sbjct: 336 NKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPE 395

Query: 259 LDRGAQIETKTKDE----LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQ 314
             +  QI+    DE     TPLH A R G       LL     I +K+K+  SP+H AA 
Sbjct: 396 FMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAAS 455

Query: 315 GDHLDCVRLLLQYDAE---IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371
              ++  + LLQ  ++   +++  L  +TPLH+AA  GH +V ++LL KGA   S   NG
Sbjct: 456 YGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDH-NG 514

Query: 372 FTPLHIACKKNHVRVMELLLKTGAS-IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
           +T LH A    + + M+++L T     D + E G T LH A+  GH   V  LL   A  
Sbjct: 515 WTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNAD- 573

Query: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNK 460
            V N +  + LH+A      EV   ++++K
Sbjct: 574 IVLNKQQASFLHLALHNKRKEVVLTIIRSK 603



 Score =  112 bits (279), Expect = 4e-24
 Identities = 101/372 (27%), Positives = 159/372 (42%), Gaps = 52/372 (13%)

Query: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGH---VKMV 61
           + F     AT    A ++G+L+     L NG  I+   +     +H A+ +G    VK++
Sbjct: 232 INFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLM 291

Query: 62  VELLHKEI-ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
           +      + I+ TT     T LH A+L    E+   L++ GA++N    +G +PL +A  
Sbjct: 292 ISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATA 351

Query: 121 ENHLEVVKFLLENGANQNV--------------------------------------ATE 142
                +V  LL  GA  ++                                         
Sbjct: 352 SASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDN 411

Query: 143 DGFTPLAVALQQGHENVVAHLINYG----TKGKVRLPALHIAARNDDTRTAAVLLQNDPN 198
           DG TPL  A +QG    V +L+ +     +K K +   LH AA      T   LLQ+  +
Sbjct: 412 DGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISD 471

Query: 199 PDVLSK---TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV 255
             +L++    G TPLH+AA   +  V QLLL +GA +  +  NG T LH AS  G    +
Sbjct: 472 TRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTM 530

Query: 256 RLLLDRGAQIETK-TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQ 314
           +++LD   +   +  +D  T LH AAR GH +   +LL H A I    K   S +H+A  
Sbjct: 531 KVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALH 589

Query: 315 GDHLDCVRLLLQ 326
               + V  +++
Sbjct: 590 NKRKEVVLTIIR 601


>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
           [Homo sapiens]
          Length = 627

 Score =  182 bits (461), Expect = 3e-45
 Identities = 136/400 (34%), Positives = 201/400 (50%), Gaps = 17/400 (4%)

Query: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308
           G+V  VR LLD G  +   T++  + L  A   G+  ++++LL   A ++ +   G ++P
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275

Query: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
           +  A+ G +LD V+LLL +DA+++  +    T L  A   G   + KVLL++GA      
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335

Query: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424
            NG TPL  A    HV V  +LL  GA I+  +    ES LT   +A + GHL +V+ LL
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392

Query: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
           + GA       ++ T L  A   GH EVA+ LL + A+VN  A   ++PL  AA  GH  
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452

Query: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543
           +  LL+E  AN       G+TPL  AAREGH E V  LL + A+    T++   T L +A
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512

Query: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603
              G   VA+ L++  A          TPL  A    +L++VK LL  G + H+    G 
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569

Query: 604 TPLHIAAKQNQVEVARSLLQYGGSANAES-----VQGVTP 638
           T L  A +    +VA  LLQ G   + +      ++G+ P
Sbjct: 570 TALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDP 609



 Score =  178 bits (451), Expect = 5e-44
 Identities = 135/379 (35%), Positives = 196/379 (51%), Gaps = 14/379 (3%)

Query: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA-KDDQTP 473
           G +  V+ LL  G S N    + E+ L +A  AG+ E+A+ LL   A V  +  K D TP
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275

Query: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
           L  A+  G+ ++VKLLL ++A+ N  +  G+T L  A   G V+ V  LL + A+     
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335

Query: 534 KKGFTPLHVAAKYGKVRVAELLLERDA----HPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
           + G TPL  AA  G V VA +LL+  A    H N   ++ LT   +A +  +LD+V+ LL
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392

Query: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649
             G          +T L  A     VEVAR LL  G   N  +    +PL LAA  GH E
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452

Query: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVA 708
           + ALL+ + AN    N  G TPL   A+EGH  +  +L+  G  ++A T     T L +A
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512

Query: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYS-PLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767
              G  ++  FL++  AD+    +LG S PL +A+Q+GH ++V  LL +GA+ +  ++ G
Sbjct: 513 CCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATG 568

Query: 768 TTPLAIAKRLGYISVTDVL 786
            T L  A   G+  V DVL
Sbjct: 569 DTALTYACENGHTDVADVL 587



 Score =  177 bits (450), Expect = 7e-44
 Identities = 140/427 (32%), Positives = 214/427 (50%), Gaps = 38/427 (8%)

Query: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
           A  +G V  V +LL +   +   T++G + L +A  AG  E+ + L+   ANV  +  KG
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271

Query: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170
             TPL  A+   +L++VK LL + A+ N  +  G T L  A   G  ++V  L+N G   
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 329

Query: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230
                                      N +  ++ G TPL  AA   ++ VA++LL+ GA
Sbjct: 330 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362

Query: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
            +N T  N    + L +A  +G++ MVR LL+ GA  E KT +  T L  A  +GHV ++
Sbjct: 363 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 421

Query: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348
            +LLD GA +     +  SP+ +AA G H++   LL++  A ++++  +  TPL  AA  
Sbjct: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481

Query: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407
           GH  +  +LL +GA  N++      T L +AC      V + L+K GA I+       TP
Sbjct: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 538

Query: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
           L  AS  GHL +VK LL  GA+ + +    +T L  A   GHT+VA  LLQ  A ++ K 
Sbjct: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQ 597

Query: 468 KDDQTPL 474
           +D +T L
Sbjct: 598 EDMKTIL 604



 Score =  173 bits (438), Expect = 2e-42
 Identities = 133/384 (34%), Positives = 193/384 (50%), Gaps = 6/384 (1%)

Query: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
           AC    V  +  LL  G S++  TE G + L +A   G+  + + LL   A+      K 
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271

Query: 438 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
           + TPL  A+  G+ ++ K LL + A VN+++    T L  A   G  ++VK+LL   AN 
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331

Query: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 555
                 GHTPL  AA  GHVE    LL+  A     + +   + L +A   G + +   L
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391

Query: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615
           LE  A          T L  A    ++++ +LLL  G   + PA +  +PL +AA    V
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451

Query: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 674
           E+A  L++ G +    + +G TPL  AA+EGH EMVALLL++ AN N   +    T L L
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511

Query: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734
               G   VAD LIK G  ++       TPL  AS  G+++LVK+LL   A+V+A T  G
Sbjct: 512 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 568

Query: 735 YSPLHQAAQQGHTDIVTLLLKNGA 758
            + L  A + GHTD+  +LL+ GA
Sbjct: 569 DTALTYACENGHTDVADVLLQAGA 592



 Score =  167 bits (424), Expect = 7e-41
 Identities = 131/386 (33%), Positives = 192/386 (49%), Gaps = 7/386 (1%)

Query: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG- 371
           + GD ++ VR LL     +++ T +  + L +A   G++ +A+VLL   A    R   G 
Sbjct: 214 SDGD-VNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGD 272

Query: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
            TPL  A    ++ +++LLL   A +++ + +G T L  A   G + IVK LL  GA+  
Sbjct: 273 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 332

Query: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLL 490
             N    TPL  AA AGH EVA+ LL + A +N  + +  ++ L  A   GH +MV+ LL
Sbjct: 333 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 392

Query: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550
           E  A+    T   HT L  A  +GHVE    LL+  A          +PL +AA  G V 
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452

Query: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY-TPLHIA 609
           +A LL+ER A+       G TPL  A    + ++V LLL +G + ++       T L +A
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512

Query: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
                 EVA  L++ G           TPL  A+QEGH E+V  LL+  AN +    +G 
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569

Query: 670 TPLHLVAQEGHVPVADVLIKHGVMVD 695
           T L    + GH  VADVL++ G  +D
Sbjct: 570 TALTYACENGHTDVADVLLQAGADLD 595



 Score =  162 bits (409), Expect = 4e-39
 Identities = 123/383 (32%), Positives = 183/383 (47%), Gaps = 6/383 (1%)

Query: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI-DAVTESGLTP 407
           G     + LLD+G   N     G + L +AC   +  + ++LL   A++ D   +  +TP
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275

Query: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
           L  AS  G+L IVK LL   A  N  +    T L  A   G  ++ K LL   A +    
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335

Query: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKE 526
           ++  TPL  AA  GH  + ++LL++ A  N  +     + L +A  +GH++ V  LLE  
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395

Query: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586
           A Q   T +  T L  A   G V VA LLL+  A  N    +  +PL +A    ++++  
Sbjct: 396 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 455

Query: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQE 645
           LL+ RG +       GYTPL  AA++   E+   LL  G + NA++ +   T L LA   
Sbjct: 456 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 515

Query: 646 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 705
           G +E+   L+   A+  LG     TPL   +QEGH+ +   L+  G  V ATT  G T L
Sbjct: 516 GFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572

Query: 706 HVASHYGNIKLVKFLLQHQADVN 728
             A   G+  +   LLQ  AD++
Sbjct: 573 TYACENGHTDVADVLLQAGADLD 595



 Score =  150 bits (380), Expect = 9e-36
 Identities = 112/359 (31%), Positives = 175/359 (48%), Gaps = 34/359 (9%)

Query: 42  NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
           N+  +  L  AS  G++ +V  LL  +  + + +  GNTAL  A   G  ++V+ L+N G
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328

Query: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160
           AN+   ++ G TPL  AA   H+EV + LL++GA  N  + E   + L +A  +GH ++V
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388

Query: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220
             L+  G   + +   +H                             T L  A    ++ 
Sbjct: 389 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 419

Query: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
           VA+LLL+ GA VN    +  +PL +A+  G+V +  LL++RGA +E    +  TPL  AA
Sbjct: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479

Query: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339
           R GH  +  +LL  GA I A+T+    + + +A  G   +    L++  A   DI L   
Sbjct: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 536

Query: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
           TPL  A+  GH  + K LL  GA  ++    G T L  AC+  H  V ++LL+ GA +D
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595



 Score =  138 bits (347), Expect = 6e-32
 Identities = 106/327 (32%), Positives = 165/327 (50%), Gaps = 13/327 (3%)

Query: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
           T  + A+  G LD     L +  D+N+ +  G   L  A   G V +V  LL++   +E 
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333

Query: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132
             + G+T L  AA AG  EV R L+++GA +N  S +   + L +A  + HL++V+FLLE
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393

Query: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------LHIAARNDDT 186
            GA+Q   T++  T L  A   GH  V   L++ G   +V +PA      L +AA     
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPLTLAACGGHV 451

Query: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHI 245
             AA+L++   N + ++  G+TPL  AA   +  +  LLL +GA++N  T +   T L +
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511

Query: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
           A   G   +   L+  GA IE       TPL  A++ GH+ + + LL  GA + A T  G
Sbjct: 512 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 568

Query: 306 LSPIHMAAQGDHLDCVRLLLQYDAEID 332
            + +  A +  H D   +LLQ  A++D
Sbjct: 569 DTALTYACENGHTDVADVLLQAGADLD 595


>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
           [Homo sapiens]
          Length = 616

 Score =  182 bits (461), Expect = 3e-45
 Identities = 136/400 (34%), Positives = 201/400 (50%), Gaps = 17/400 (4%)

Query: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308
           G+V  VR LLD G  +   T++  + L  A   G+  ++++LL   A ++ +   G ++P
Sbjct: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264

Query: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
           +  A+ G +LD V+LLL +DA+++  +    T L  A   G   + KVLL++GA      
Sbjct: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324

Query: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424
            NG TPL  A    HV V  +LL  GA I+  +    ES LT   +A + GHL +V+ LL
Sbjct: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 381

Query: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
           + GA       ++ T L  A   GH EVA+ LL + A+VN  A   ++PL  AA  GH  
Sbjct: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441

Query: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543
           +  LL+E  AN       G+TPL  AAREGH E V  LL + A+    T++   T L +A
Sbjct: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501

Query: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603
              G   VA+ L++  A          TPL  A    +L++VK LL  G + H+    G 
Sbjct: 502 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 558

Query: 604 TPLHIAAKQNQVEVARSLLQYGGSANAES-----VQGVTP 638
           T L  A +    +VA  LLQ G   + +      ++G+ P
Sbjct: 559 TALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDP 598



 Score =  178 bits (451), Expect = 5e-44
 Identities = 135/379 (35%), Positives = 196/379 (51%), Gaps = 14/379 (3%)

Query: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA-KDDQTP 473
           G +  V+ LL  G S N    + E+ L +A  AG+ E+A+ LL   A V  +  K D TP
Sbjct: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264

Query: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
           L  A+  G+ ++VKLLL ++A+ N  +  G+T L  A   G V+ V  LL + A+     
Sbjct: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324

Query: 534 KKGFTPLHVAAKYGKVRVAELLLERDA----HPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
           + G TPL  AA  G V VA +LL+  A    H N   ++ LT   +A +  +LD+V+ LL
Sbjct: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 381

Query: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649
             G          +T L  A     VEVAR LL  G   N  +    +PL LAA  GH E
Sbjct: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441

Query: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVA 708
           + ALL+ + AN    N  G TPL   A+EGH  +  +L+  G  ++A T     T L +A
Sbjct: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501

Query: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYS-PLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767
              G  ++  FL++  AD+    +LG S PL +A+Q+GH ++V  LL +GA+ +  ++ G
Sbjct: 502 CCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATG 557

Query: 768 TTPLAIAKRLGYISVTDVL 786
            T L  A   G+  V DVL
Sbjct: 558 DTALTYACENGHTDVADVL 576



 Score =  177 bits (450), Expect = 7e-44
 Identities = 140/427 (32%), Positives = 214/427 (50%), Gaps = 38/427 (8%)

Query: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
           A  +G V  V +LL +   +   T++G + L +A  AG  E+ + L+   ANV  +  KG
Sbjct: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260

Query: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170
             TPL  A+   +L++VK LL + A+ N  +  G T L  A   G  ++V  L+N G   
Sbjct: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 318

Query: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230
                                      N +  ++ G TPL  AA   ++ VA++LL+ GA
Sbjct: 319 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 351

Query: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
            +N T  N    + L +A  +G++ MVR LL+ GA  E KT +  T L  A  +GHV ++
Sbjct: 352 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 410

Query: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348
            +LLD GA +     +  SP+ +AA G H++   LL++  A ++++  +  TPL  AA  
Sbjct: 411 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 470

Query: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407
           GH  +  +LL +GA  N++      T L +AC      V + L+K GA I+       TP
Sbjct: 471 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 527

Query: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
           L  AS  GHL +VK LL  GA+ + +    +T L  A   GHT+VA  LLQ  A ++ K 
Sbjct: 528 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQ 586

Query: 468 KDDQTPL 474
           +D +T L
Sbjct: 587 EDMKTIL 593



 Score =  173 bits (438), Expect = 2e-42
 Identities = 133/384 (34%), Positives = 193/384 (50%), Gaps = 6/384 (1%)

Query: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
           AC    V  +  LL  G S++  TE G + L +A   G+  + + LL   A+      K 
Sbjct: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260

Query: 438 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
           + TPL  A+  G+ ++ K LL + A VN+++    T L  A   G  ++VK+LL   AN 
Sbjct: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320

Query: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 555
                 GHTPL  AA  GHVE    LL+  A     + +   + L +A   G + +   L
Sbjct: 321 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 380

Query: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615
           LE  A          T L  A    ++++ +LLL  G   + PA +  +PL +AA    V
Sbjct: 381 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 440

Query: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 674
           E+A  L++ G +    + +G TPL  AA+EGH EMVALLL++ AN N   +    T L L
Sbjct: 441 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 500

Query: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734
               G   VAD LIK G  ++       TPL  AS  G+++LVK+LL   A+V+A T  G
Sbjct: 501 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 557

Query: 735 YSPLHQAAQQGHTDIVTLLLKNGA 758
            + L  A + GHTD+  +LL+ GA
Sbjct: 558 DTALTYACENGHTDVADVLLQAGA 581



 Score =  167 bits (424), Expect = 7e-41
 Identities = 131/386 (33%), Positives = 192/386 (49%), Gaps = 7/386 (1%)

Query: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG- 371
           + GD ++ VR LL     +++ T +  + L +A   G++ +A+VLL   A    R   G 
Sbjct: 203 SDGD-VNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGD 261

Query: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
            TPL  A    ++ +++LLL   A +++ + +G T L  A   G + IVK LL  GA+  
Sbjct: 262 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 321

Query: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD-DQTPLHCAARIGHTNMVKLLL 490
             N    TPL  AA AGH EVA+ LL + A +N  + +  ++ L  A   GH +MV+ LL
Sbjct: 322 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 381

Query: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550
           E  A+    T   HT L  A  +GHVE    LL+  A          +PL +AA  G V 
Sbjct: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441

Query: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY-TPLHIA 609
           +A LL+ER A+       G TPL  A    + ++V LLL +G + ++       T L +A
Sbjct: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501

Query: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669
                 EVA  L++ G           TPL  A+QEGH E+V  LL+  AN +    +G 
Sbjct: 502 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 558

Query: 670 TPLHLVAQEGHVPVADVLIKHGVMVD 695
           T L    + GH  VADVL++ G  +D
Sbjct: 559 TALTYACENGHTDVADVLLQAGADLD 584



 Score =  162 bits (409), Expect = 4e-39
 Identities = 123/383 (32%), Positives = 183/383 (47%), Gaps = 6/383 (1%)

Query: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI-DAVTESGLTP 407
           G     + LLD+G   N     G + L +AC   +  + ++LL   A++ D   +  +TP
Sbjct: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264

Query: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
           L  AS  G+L IVK LL   A  N  +    T L  A   G  ++ K LL   A +    
Sbjct: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324

Query: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKE 526
           ++  TPL  AA  GH  + ++LL++ A  N  +     + L +A  +GH++ V  LLE  
Sbjct: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 384

Query: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586
           A Q   T +  T L  A   G V VA LLL+  A  N    +  +PL +A    ++++  
Sbjct: 385 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 444

Query: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQE 645
           LL+ RG +       GYTPL  AA++   E+   LL  G + NA++ +   T L LA   
Sbjct: 445 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 504

Query: 646 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 705
           G +E+   L+   A+  LG     TPL   +QEGH+ +   L+  G  V ATT  G T L
Sbjct: 505 GFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 561

Query: 706 HVASHYGNIKLVKFLLQHQADVN 728
             A   G+  +   LLQ  AD++
Sbjct: 562 TYACENGHTDVADVLLQAGADLD 584



 Score =  150 bits (380), Expect = 9e-36
 Identities = 112/359 (31%), Positives = 175/359 (48%), Gaps = 34/359 (9%)

Query: 42  NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
           N+  +  L  AS  G++ +V  LL  +  + + +  GNTAL  A   G  ++V+ L+N G
Sbjct: 258 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317

Query: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160
           AN+   ++ G TPL  AA   H+EV + LL++GA  N  + E   + L +A  +GH ++V
Sbjct: 318 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 377

Query: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220
             L+  G   + +   +H                             T L  A    ++ 
Sbjct: 378 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 408

Query: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
           VA+LLL+ GA VN    +  +PL +A+  G+V +  LL++RGA +E    +  TPL  AA
Sbjct: 409 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 468

Query: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339
           R GH  +  +LL  GA I A+T+    + + +A  G   +    L++  A   DI L   
Sbjct: 469 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 525

Query: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
           TPL  A+  GH  + K LL  GA  ++    G T L  AC+  H  V ++LL+ GA +D
Sbjct: 526 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584



 Score =  138 bits (347), Expect = 6e-32
 Identities = 106/327 (32%), Positives = 165/327 (50%), Gaps = 13/327 (3%)

Query: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
           T  + A+  G LD     L +  D+N+ +  G   L  A   G V +V  LL++   +E 
Sbjct: 263 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322

Query: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132
             + G+T L  AA AG  EV R L+++GA +N  S +   + L +A  + HL++V+FLLE
Sbjct: 323 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 382

Query: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------LHIAARNDDT 186
            GA+Q   T++  T L  A   GH  V   L++ G   +V +PA      L +AA     
Sbjct: 383 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPLTLAACGGHV 440

Query: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHI 245
             AA+L++   N + ++  G+TPL  AA   +  +  LLL +GA++N  T +   T L +
Sbjct: 441 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 500

Query: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
           A   G   +   L+  GA IE       TPL  A++ GH+ + + LL  GA + A T  G
Sbjct: 501 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 557

Query: 306 LSPIHMAAQGDHLDCVRLLLQYDAEID 332
            + +  A +  H D   +LLQ  A++D
Sbjct: 558 DTALTYACENGHTDVADVLLQAGADLD 584


>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
          Length = 1050

 Score =  169 bits (427), Expect = 3e-41
 Identities = 133/431 (30%), Positives = 196/431 (45%), Gaps = 52/431 (12%)

Query: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
           TPLHVAA CG   +  +L+ KGA  N+   +G TPLH+AC+K +  V  LLL   AS + 
Sbjct: 465 TPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEV 524

Query: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASP---NVSNVKVETPLHMAARAGHTEVAKYL 456
              +G TPLH+A   GH   VK L+         ++ N K +TPLH+AAR G+  V + L
Sbjct: 525 QDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETL 584

Query: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVK---LLLENNANPNLA-------------- 499
           LQN A    + +  +TPL CA      ++++   L  E     + A              
Sbjct: 585 LQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQ 644

Query: 500 --TTAGHTPLHIAARE-------------------GHVETVLALLE---KEASQACMTKK 535
             +T+  + +  ++R+                   G +E V  LLE   ++   A  T  
Sbjct: 645 ESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVS 704

Query: 536 GFTP--LHVAAKYGKVRVAELLLER----DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
              P   H   +  K   A+  L +        N   ++G +PLHVA  H   D++ LLL
Sbjct: 705 AADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLL 764

Query: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649
             G +  +   +   PLH+A +Q   +V + LL      N + + G TPL  A   GH E
Sbjct: 765 KHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHE 824

Query: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
           +VALLL   A+ N  N  G T LH    E HV V ++L+ HG  V    +   T +  A 
Sbjct: 825 LVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAE 884

Query: 710 HYGNIKLVKFL 720
              N K+++ L
Sbjct: 885 Q--NSKIMELL 893



 Score =  161 bits (408), Expect = 5e-39
 Identities = 143/545 (26%), Positives = 232/545 (42%), Gaps = 53/545 (9%)

Query: 313 AQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF 372
           A G+  +  RLL Q D + D +      PL     C      ++       P SR   G 
Sbjct: 406 ASGNQKEVERLLSQEDHDKDTVQ-KMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDDRGH 464

Query: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
           TPLH+A       +++LL+  GA ++A    G TPLH+A   G+  +   LL   AS  V
Sbjct: 465 TPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEV 524

Query: 433 SNVKVETPLHMAARAGHTEVAKYLLQ---NKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489
            +    TPLH+A   GH +  K L+       +++   +   TPLH AAR G+  +++ L
Sbjct: 525 QDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETL 584

Query: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALLE---------KEASQACMTKKGFTPL 540
           L+N A+  +      TPL  A        +L+++E         +++S+A +     +  
Sbjct: 585 LQNGASTEIQNRLKETPLKCALNS----KILSVMEAYHLSFERRQKSSEAPVQSPQRSVD 640

Query: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600
            ++ +      + +               +  L  AV   +L++V+ LL         A 
Sbjct: 641 SISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAE 700

Query: 601 NGYT-------------PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH 647
           +  +             P    A++   +V  S    G   N  S  G +PLH+AA  G 
Sbjct: 701 DTVSAADPEFCHPLCQCPKCAPAQKRLAKVPAS----GLGVNVTSQDGSSPLHVAALHGR 756

Query: 648 AEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHV 707
           A+++ LLL   AN    N     PLHL  Q+GH  V   L+      +     G TPL  
Sbjct: 757 ADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIY 816

Query: 708 ASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767
           A   G+ +LV  LLQH A +NA    G + LH+A  + H  +V LLL +GAS   ++   
Sbjct: 817 ACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQ 876

Query: 768 TTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISF 827
            T +  A++     + ++L+VV                 P  V  + DV+E + +E ++ 
Sbjct: 877 RTAVDCAEQNS--KIMELLQVV-----------------PSCVASLDDVAETDRKEYVTV 917

Query: 828 KAERR 832
           K  ++
Sbjct: 918 KIRKK 922



 Score =  159 bits (403), Expect = 2e-38
 Identities = 132/424 (31%), Positives = 191/424 (45%), Gaps = 58/424 (13%)

Query: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
           +G+T LH+AA+ GQ  ++  LV+ GA VNA    G TPL++A Q+ +  V   LL   A+
Sbjct: 462 RGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521

Query: 137 QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRL--------PALHIAARNDDTRT 188
             V   +G TPL +A   GHE+ V  L+ Y  +   RL          LHIAAR      
Sbjct: 522 AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVE-SCRLDIGNEKGDTPLHIAARWGYQGV 580

Query: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ---LLLNRGASVNFTP-QNGITPLH 244
              LLQN  + ++ ++   TPL  A + + L+V +   L   R    +  P Q+    + 
Sbjct: 581 IETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVD 640

Query: 245 IASRRGNVIMVRLLLDRGAQIETKTKD--ELTPLHCAARNGHVRISEILLD--------- 293
             S+  +      +     Q ETK KD  E+  L  A  +G + +   LL+         
Sbjct: 641 SISQESSTSSFSSMSASSRQEETK-KDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDA 699

Query: 294 ---------------------------------HGAPIQAKTKNGLSPIHMAAQGDHLDC 320
                                             G  +   +++G SP+H+AA     D 
Sbjct: 700 EDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADL 759

Query: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380
           + LLL++ A       D   PLH+A   GH +V K LLD  AKPN + L+G TPL  AC 
Sbjct: 760 IPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACS 819

Query: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440
             H  ++ LLL+ GASI+A    G T LH A    H+ +V+ LL  GAS  V N +  T 
Sbjct: 820 GGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTA 879

Query: 441 LHMA 444
           +  A
Sbjct: 880 VDCA 883



 Score =  138 bits (347), Expect = 6e-32
 Identities = 125/470 (26%), Positives = 193/470 (41%), Gaps = 83/470 (17%)

Query: 106 AQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN 165
           ++  +G TPL++AA      ++  L+  GA  N     G TPL +A Q+G+++V   L++
Sbjct: 458 SRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLH 517

Query: 166 YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLL 225
           Y    +V+                                G TPLH+A  Y + +  + L
Sbjct: 518 YKASAEVQ-----------------------------DNNGNTPLHLACTYGHEDCVKAL 548

Query: 226 LN---RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282
           +        ++   + G TPLHIA+R G   ++  LL  GA  E + + + TPL CA  +
Sbjct: 549 VYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNS 608

Query: 283 G--------HVRISEILLDHGAPIQA---------------------------KTKNGLS 307
                    H+          AP+Q+                           +TK    
Sbjct: 609 KILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYR 668

Query: 308 PIHM----AAQGDHLDCVRLLLQY---DAEIDDITLDHLTP--LHVAAHC-----GHHRV 353
            +       A GD L+ VR LL++   D E  + T+    P   H    C        R+
Sbjct: 669 EVEKLLRAVADGD-LEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRL 727

Query: 354 AKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASF 413
           AKV    G   N  + +G +PLH+A       ++ LLLK GA+  A       PLH+A  
Sbjct: 728 AKVPAS-GLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQ 786

Query: 414 MGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP 473
            GH  +VK LL   A PN  ++   TPL  A   GH E+   LLQ+ A +NA      T 
Sbjct: 787 QGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTA 846

Query: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523
           LH A    H  +V+LLL + A+  +      T +  A +   +  +L ++
Sbjct: 847 LHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVV 896



 Score =  114 bits (285), Expect = 9e-25
 Identities = 114/415 (27%), Positives = 172/415 (41%), Gaps = 26/415 (6%)

Query: 13  ATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII-- 70
           AT    A + G     L  L         + NG   LHLA   GH   V  L++ ++   
Sbjct: 497 ATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESC 556

Query: 71  -LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK- 128
            L+   +KG+T LHIAA  G   V+  L+  GA+   Q++   TPL  A     L V++ 
Sbjct: 557 RLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEA 616

Query: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV--------RLPALHIA 180
           + L     Q  +     +P         E+  +   +     +          +  L  A
Sbjct: 617 YHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRA 676

Query: 181 ARNDDTRTAAVLLQ-----NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR----GAS 231
             + D      LL+      +   D +S       H          AQ  L +    G  
Sbjct: 677 VADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLG 736

Query: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
           VN T Q+G +PLH+A+  G   ++ LLL  GA    +  D+  PLH A + GH ++ + L
Sbjct: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796

Query: 292 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH 351
           LD  A    K  +G +P+  A  G H + V LLLQ+ A I+       T LH A    H 
Sbjct: 797 LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHV 856

Query: 352 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL---KTGASIDAVTES 403
            V ++LL  GA  + + LN      + C + + ++MELL       AS+D V E+
Sbjct: 857 FVVELLLLHGA--SVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDDVAET 909



 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 64/201 (31%), Positives = 97/201 (48%), Gaps = 5/201 (2%)

Query: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600
           H+A+  G  +  E LL ++ H     +    PL        L   +L  P   +P S   
Sbjct: 404 HIAS--GNQKEVERLLSQEDHDKDTVQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDD 461

Query: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
            G+TPLH+AA   Q  +   L+  G   NA    G TPLHLA Q+G+  +  LLL  +A+
Sbjct: 462 RGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521

Query: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV---MVDATTRMGYTPLHVASHYGNIKLV 717
             + + +G TPLHL    GH      L+ + V    +D     G TPLH+A+ +G   ++
Sbjct: 522 AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVI 581

Query: 718 KFLLQHQADVNAKTKLGYSPL 738
           + LLQ+ A    + +L  +PL
Sbjct: 582 ETLLQNGASTEIQNRLKETPL 602



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 66/215 (30%), Positives = 107/215 (49%), Gaps = 6/215 (2%)

Query: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693
           +G TPLH+AA  G A ++ LL+SK A  N  +  G TPLHL  Q+G+  V  +L+ +   
Sbjct: 462 RGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521

Query: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD---VNAKTKLGYSPLHQAAQQGHTDIV 750
            +     G TPLH+A  YG+   VK L+ +  +   ++   + G +PLH AA+ G+  ++
Sbjct: 522 AEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVI 581

Query: 751 TLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETV 810
             LL+NGAS    +    TPL  A     +SV +   +  +       S+    S   +V
Sbjct: 582 ETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQ--KSSEAPVQSPQRSV 639

Query: 811 DEILDVSEDEGEELISFKAERRDS-RDVDEEKELL 844
           D I   S       +S  + + ++ +D  E ++LL
Sbjct: 640 DSISQESSTSSFSSMSASSRQEETKKDYREVEKLL 674



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 48/149 (32%), Positives = 71/149 (47%)

Query: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
           V     D ++    AA  G  D     L++G +    N +    LHLA ++GH ++V  L
Sbjct: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796

Query: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
           L            GNT L  A   G  E+V  L+ +GA++NA + KG T L+ A  E H+
Sbjct: 797 LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHV 856

Query: 125 EVVKFLLENGANQNVATEDGFTPLAVALQ 153
            VV+ LL +GA+  V  +   T +  A Q
Sbjct: 857 FVVELLLLHGASVQVLNKRQRTAVDCAEQ 885



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 34/121 (28%), Positives = 54/121 (44%)

Query: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
           + G R AD A     A + G+       L +    N  + +G   L  A   GH ++V  
Sbjct: 769 NAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVAL 828

Query: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
           LL     +  +  KGNTALH A +     VV  L+ +GA+V   +++  T +  A Q + 
Sbjct: 829 LLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSK 888

Query: 124 L 124
           +
Sbjct: 889 I 889


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.131    0.375 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,961,315
Number of Sequences: 37866
Number of extensions: 3350089
Number of successful extensions: 23172
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 368
Number of HSP's successfully gapped in prelim test: 128
Number of HSP's that attempted gapping in prelim test: 7801
Number of HSP's gapped (non-prelim): 6040
length of query: 1856
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1739
effective length of database: 13,817,196
effective search space: 24028103844
effective search space used: 24028103844
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.