BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|67782338 amyloid precursor-like protein 1 isoform 1 precursor [Homo sapiens] (651 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|67782338 amyloid precursor-like protein 1 isoform 1 precursor... 1322 0.0 gi|4885065 amyloid precursor-like protein 1 isoform 2 precursor ... 1316 0.0 gi|214010183 amyloid beta (A4) precursor-like protein 2 isoform ... 472 e-133 gi|41406057 amyloid beta A4 protein isoform c precursor [Homo sa... 445 e-125 gi|209915570 amyloid beta A4 protein isoform e precursor [Homo s... 395 e-110 gi|41406055 amyloid beta A4 protein isoform b precursor [Homo sa... 359 4e-99 gi|4502147 amyloid beta (A4) precursor-like protein 2 isoform 1 ... 303 3e-82 gi|214010185 amyloid beta (A4) precursor-like protein 2 isoform ... 301 1e-81 gi|214010181 amyloid beta (A4) precursor-like protein 2 isoform ... 301 1e-81 gi|4502167 amyloid beta A4 protein isoform a precursor [Homo sap... 257 2e-68 gi|209915573 amyloid beta A4 protein isoform f precursor [Homo s... 257 2e-68 gi|91208420 bassoon protein [Homo sapiens] 45 2e-04 gi|41322923 plectin 1 isoform 11 [Homo sapiens] 42 0.002 gi|41322914 plectin 1 isoform 10 [Homo sapiens] 42 0.002 gi|41322919 plectin 1 isoform 8 [Homo sapiens] 42 0.002 gi|41322910 plectin 1 isoform 7 [Homo sapiens] 42 0.002 gi|41322916 plectin 1 isoform 6 [Homo sapiens] 42 0.002 gi|41322908 plectin 1 isoform 3 [Homo sapiens] 42 0.002 gi|41322912 plectin 1 isoform 2 [Homo sapiens] 42 0.002 gi|47607492 plectin 1 isoform 1 [Homo sapiens] 42 0.002 gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 41 0.004 gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 41 0.004 gi|138175817 zinc finger protein 236 [Homo sapiens] 41 0.004 gi|209862789 microtubule associated monoxygenase, calponin and L... 40 0.005 gi|32484977 angiomotin like 2 [Homo sapiens] 40 0.005 gi|33356148 formin-like 1 [Homo sapiens] 40 0.007 gi|115648142 centrosomal protein 164kDa [Homo sapiens] 40 0.009 gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 39 0.011 gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 39 0.011 gi|4506803 stem cell growth factor precursor [Homo sapiens] 39 0.011 >gi|67782338 amyloid precursor-like protein 1 isoform 1 precursor [Homo sapiens] Length = 651 Score = 1322 bits (3421), Expect = 0.0 Identities = 651/651 (100%), Positives = 651/651 (100%) Query: 1 MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC 60 MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC Sbjct: 1 MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC 60 Query: 61 GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC 120 GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC Sbjct: 61 GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC 120 Query: 121 GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA 180 GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA Sbjct: 121 GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA 180 Query: 181 CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA 240 CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA Sbjct: 181 CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA 240 Query: 241 EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM 300 EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM Sbjct: 241 EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM 300 Query: 301 PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT 360 PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT Sbjct: 301 PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT 360 Query: 361 LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE 420 LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE Sbjct: 361 LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE 420 Query: 421 QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ 480 QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ Sbjct: 421 QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ 480 Query: 481 IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEK 540 IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEK Sbjct: 481 IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEK 540 Query: 541 MNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLS 600 MNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLS Sbjct: 541 MNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLS 600 Query: 601 MLLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP 651 MLLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP Sbjct: 601 MLLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP 651 >gi|4885065 amyloid precursor-like protein 1 isoform 2 precursor [Homo sapiens] Length = 650 Score = 1316 bits (3405), Expect = 0.0 Identities = 650/651 (99%), Positives = 650/651 (99%), Gaps = 1/651 (0%) Query: 1 MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC 60 MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC Sbjct: 1 MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC 60 Query: 61 GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC 120 GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC Sbjct: 61 GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC 120 Query: 121 GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA 180 GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA Sbjct: 121 GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA 180 Query: 181 CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA 240 CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA Sbjct: 181 CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA 240 Query: 241 EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM 300 EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM Sbjct: 241 EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM 300 Query: 301 PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT 360 PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT Sbjct: 301 PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT 360 Query: 361 LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE 420 LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE Sbjct: 361 LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE 420 Query: 421 QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ 480 QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ Sbjct: 421 QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ 480 Query: 481 IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEK 540 IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKD DTPMTLPKGSTEQDAASPEKEK Sbjct: 481 IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKD-DTPMTLPKGSTEQDAASPEKEK 539 Query: 541 MNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLS 600 MNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLS Sbjct: 540 MNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLS 599 Query: 601 MLLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP 651 MLLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP Sbjct: 600 MLLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP 650 >gi|214010183 amyloid beta (A4) precursor-like protein 2 isoform 3 [Homo sapiens] Length = 695 Score = 472 bits (1214), Expect = e-133 Identities = 279/690 (40%), Positives = 388/690 (56%), Gaps = 76/690 (11%) Query: 24 LPLLLLLLRAQPAIGSLAG------GSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPD 77 L LLLL+ PA+ +LAG + G A Q+A CG+L +H +++TG+WEPD Sbjct: 15 LLLLLLVGLTAPAL-ALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPD 73 Query: 78 PQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVP 137 P ++ C + VL+YC++MYPELQI V +A Q + ++ WC + C V P Sbjct: 74 PTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKK-QCKSRF--VTP 130 Query: 138 FRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPC 197 F+CL GEFVS+ LLVPE C+F H+ERM+ CE+ H +EAC +QG+ L+ GMLLPC Sbjct: 131 FKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPC 190 Query: 198 GSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEE-----ESFPQP 252 G D+F G EYVCCP +G S E EDEEE+ FP Sbjct: 191 GVDQFHGTEYVCCPQT-------KIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTE 243 Query: 253 VD--------------------------DYFVEPPQAEE--EEETVPPPSSHTLAVVG-- 282 D DY+ + + ++ EE P S T++ Sbjct: 244 ADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEIT 303 Query: 283 ---KVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQS 339 KV PTP PT+ VD+YF + +EH F +AK LE R +++ V +EW A+ Q+ Sbjct: 304 HDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQA 363 Query: 340 KNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAAL 399 KNLPKA+RQ L +HFQ++++ LE++ + E+Q+LVETH RV A++ND+RR ALE +LAAL Sbjct: 364 KNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAAL 423 Query: 400 QADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEER 459 Q+DPP+ R+L ALRRY+RAE K++ HT+RHYQHV AVDPEKA QM+ QV THL VIEER Sbjct: 424 QSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEER 483 Query: 460 VNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGG------SSEDKGGLQP- 512 NQSL LL + P++AQE++ +I ELL + + A SSE+ + P Sbjct: 484 RNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPF 543 Query: 513 -PDSKDADTPMTLPKGSTEQDAA----------SPEKEKMNPLEQYERKVNASVPRGFPF 561 P P G EQD S K N + V + Sbjct: 544 HPFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERV 603 Query: 562 HSSEIQRDELAP--AGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVE 619 E +R+ + P +S A+ GLL++ ++IV+S+++L RK+ YG ISHG+VE Sbjct: 604 GGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVML-RKRQYGTISHGIVE 662 Query: 620 VDPMLTLEEQQLRELQRHGYENPTYRFLEE 649 VDPMLT EE+ L ++Q HGYENPTY++LE+ Sbjct: 663 VDPMLTPEERHLNKMQNHGYENPTYKYLEQ 692 >gi|41406057 amyloid beta A4 protein isoform c precursor [Homo sapiens] Length = 695 Score = 445 bits (1145), Expect = e-125 Identities = 273/699 (39%), Positives = 386/699 (55%), Gaps = 79/699 (11%) Query: 23 LLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSR 82 +LP L LLL A +L + G A Q+A CGRL +H +++ G+W+ DP ++ Sbjct: 1 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60 Query: 83 RCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLP 142 C+ + +L+YC+++YPELQI V +A Q + ++ WC R HPH V+P+RCL Sbjct: 61 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHF-VIPYRCLV 119 Query: 143 GEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRF 202 GEFVS+ALLVP+ C+FLHQERMD CE+ H A+E CS + LH GMLLPCG D+F Sbjct: 120 GEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKF 179 Query: 203 RGVEYVCCPPPGTPD--PSGTAVGDPSTRSW-------PPGSR---VEGAEDEEEEESFP 250 RGVE+VCCP D S A D S W GS VE AE+EE E Sbjct: 180 RGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEE 239 Query: 251 QPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPT-----------------DG 293 + DD + E EEE P T T T T D Sbjct: 240 EEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDA 299 Query: 294 VDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEH 353 VD Y PG+ +EH F +AK LE + ++++VMREW A+ Q+KNLPKAD++A+ +H Sbjct: 300 VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH 359 Query: 354 FQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLAL 413 FQ +++LE++ + ERQ+LVETH RV A++ND+RR ALE ++ ALQA PP+ V L Sbjct: 360 FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML 419 Query: 414 RRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHL 473 ++Y+RAEQK+++HTL+H++HV VDP+KA Q+R QV THL+VI ER+NQSL LL P + Sbjct: 420 KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV 479 Query: 474 AQELRPQIQELLHSEH----------------------LGPSELEA-------PAPGGSS 504 A+E++ ++ ELL E L PS E P G S Sbjct: 480 AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS 539 Query: 505 EDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEK------------MNPLEQYERKVN 552 D LQP S AD+ + E A P ++ + E E K++ Sbjct: 540 LD--DLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMD 597 Query: 553 ASV--PRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPY 610 A G+ H Q+ G ++ A+ GL++ G ++IV+++++L +KK Y Sbjct: 598 AEFRHDSGYEVHH---QKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVML-KKKQY 653 Query: 611 GAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEE 649 +I HGVVEVD +T EE+ L ++Q++GYENPTY+F E+ Sbjct: 654 TSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQ 692 >gi|209915570 amyloid beta A4 protein isoform e precursor [Homo sapiens] Length = 639 Score = 395 bits (1016), Expect = e-110 Identities = 248/625 (39%), Positives = 344/625 (55%), Gaps = 79/625 (12%) Query: 97 QMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGC 156 ++YPELQI V +A Q + ++ WC R HPH V+P+RCL GEFVS+ALLVP+ C Sbjct: 19 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHF-VIPYRCLVGEFVSDALLVPDKC 77 Query: 157 RFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTP 216 +FLHQERMD CE+ H A+E CS + LH GMLLPCG D+FRGVE+VCCP Sbjct: 78 KFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEES 137 Query: 217 D--PSGTAVGDPSTRSW-------PPGSR---VEGAEDEEEEESFPQPVDDYFVEPPQAE 264 D S A D S W GS VE AE+EE E + DD + E Sbjct: 138 DNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDE 197 Query: 265 EEEETVPPPSSHTLAVVGKVTPTPRPT-----------------DGVDIYFGMPGEISEH 307 EEE P T T T T D VD Y PG+ +EH Sbjct: 198 VEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEH 257 Query: 308 EGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSG 367 F +AK LE + ++++VMREW A+ Q+KNLPKAD++A+ +HFQ +++LE++ + Sbjct: 258 AHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAAN 317 Query: 368 ERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHT 427 ERQ+LVETH RV A++ND+RR ALE ++ ALQA PP+ V L++Y+RAEQK+++HT Sbjct: 318 ERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHT 377 Query: 428 LRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHS 487 L+H++HV VDP+KA Q+R QV THL+VI ER+NQSL LL P +A+E++ ++ ELL Sbjct: 378 LKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQK 437 Query: 488 EH----------------------LGPSELEA-------PAPGGSSEDKGGLQPPDSKDA 518 E L PS E P G S D LQP S A Sbjct: 438 EQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLD--DLQPWHSFGA 495 Query: 519 DTPMTLPKGSTEQDAASPEKEK------------MNPLEQYERKVNASV--PRGFPFHSS 564 D+ + E A P ++ + E E K++A G+ H Sbjct: 496 DSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHH- 554 Query: 565 EIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPML 624 Q+ G ++ A+ GL++ G ++IV+++++L +KK Y +I HGVVEVD + Sbjct: 555 --QKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVML-KKKQYTSIHHGVVEVDAAV 611 Query: 625 TLEEQQLRELQRHGYENPTYRFLEE 649 T EE+ L ++Q++GYENPTY+F E+ Sbjct: 612 TPEERHLSKMQQNGYENPTYKFFEQ 636 >gi|41406055 amyloid beta A4 protein isoform b precursor [Homo sapiens] Length = 751 Score = 359 bits (922), Expect = 4e-99 Identities = 257/759 (33%), Positives = 366/759 (48%), Gaps = 143/759 (18%) Query: 23 LLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSR 82 +LP L LLL A +L + G A Q+A CGRL +H +++ G+W+ DP ++ Sbjct: 1 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60 Query: 83 RCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLP 142 C+ + +L+YC+++YPELQI V +A Q + ++ WC R HPH V+P+RCL Sbjct: 61 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHF-VIPYRCLV 119 Query: 143 GEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRF 202 GEFVS+ALLVP+ C+FLHQERMD CE+ H A+E CS + LH GMLLPCG D+F Sbjct: 120 GEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKF 179 Query: 203 RGVEYVCCPPPGTPD--PSGTAVGDPSTRSW-------PPGSR---VEGAEDEEEEESFP 250 RGVE+VCCP D S A D S W GS VE AE+EE E Sbjct: 180 RGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEE 239 Query: 251 QPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVD--------------- 295 + DD + E EEE P T T T T+ V+ Sbjct: 240 EEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGP 299 Query: 296 -------IYFGMPGEISEHE---------GFLRAKMDLEERRMRQINEVMREWAMA---- 335 YF +++E + G R D EE M + A + Sbjct: 300 CRAMISRWYF----DVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDA 355 Query: 336 ----------DNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ--------------- 370 +N+ + KA + +H + + Q + E ERQ Sbjct: 356 VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH 415 Query: 371 -----------------RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLAL 413 +LVETH RV A++ND+RR ALE ++ ALQA PP+ V L Sbjct: 416 FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML 475 Query: 414 RRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHL 473 ++Y+RAEQK+++HTL+H++HV VDP+KA Q+R QV THL+VI ER+NQSL LL P + Sbjct: 476 KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV 535 Query: 474 AQELRPQIQELLHSEH----------------------LGPSELEA-------PAPGGSS 504 A+E++ ++ ELL E L PS E P G S Sbjct: 536 AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS 595 Query: 505 EDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEK------------MNPLEQYERKVN 552 D LQP S AD+ + E A P ++ + E E K++ Sbjct: 596 LD--DLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMD 653 Query: 553 ASV--PRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPY 610 A G+ H Q+ G ++ A+ GL++ G ++IV+++++L +KK Y Sbjct: 654 AEFRHDSGYEVHH---QKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVML-KKKQY 709 Query: 611 GAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEE 649 +I HGVVEVD +T EE+ L ++Q++GYENPTY+F E+ Sbjct: 710 TSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQ 748 >gi|4502147 amyloid beta (A4) precursor-like protein 2 isoform 1 [Homo sapiens] Length = 763 Score = 303 bits (776), Expect = 3e-82 Identities = 172/398 (43%), Positives = 243/398 (61%), Gaps = 33/398 (8%) Query: 284 VTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLP 343 + PTP PT+ VD+YF + +EH F +AK LE R +++ V +EW A+ Q+KNLP Sbjct: 364 IPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLP 423 Query: 344 KADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADP 403 KA+RQ L +HFQ++++ LE++ + E+Q+LVETH RV A++ND+RR ALE +LAALQ+DP Sbjct: 424 KAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDP 483 Query: 404 PQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQS 463 P+ R+L ALRRY+RAE K++ HT+RHYQHV AVDPEKA QM+ QV THL VIEER NQS Sbjct: 484 PRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQS 543 Query: 464 LGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGG------SSEDKGGLQP----- 512 L LL + P++AQE++ +I ELL + + A SSE+ + P Sbjct: 544 LSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFH 603 Query: 513 -----PDSKDADT----PMTLPKGSTEQDAA----------SPEKEKMNPLEQYERKVNA 553 P+++D PM G EQD S K N + V Sbjct: 604 PFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKE 663 Query: 554 SVPRGFPFHSSEIQRDELAP--AGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYG 611 + E +R+ + P +S A+ GLL++ ++IV+S+++L RK+ YG Sbjct: 664 MIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVML-RKRQYG 722 Query: 612 AISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEE 649 ISHG+VEVDPMLT EE+ L ++Q HGYENPTY++LE+ Sbjct: 723 TISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQ 760 Score = 188 bits (478), Expect = 1e-47 Identities = 104/257 (40%), Positives = 143/257 (55%), Gaps = 23/257 (8%) Query: 24 LPLLLLLLRAQPAIGSLAG------GSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPD 77 L LLLL+ PA+ +LAG + G A Q+A CG+L +H +++TG+WEPD Sbjct: 15 LLLLLLVGLTAPAL-ALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPD 73 Query: 78 PQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVP 137 P ++ C + VL+YC++MYPELQI V +A Q + ++ WC + C V P Sbjct: 74 PTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKK-QCKSRF--VTP 130 Query: 138 FRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPC 197 F+CL GEFVS+ LLVPE C+F H+ERM+ CE+ H +EAC +QG+ L+ GMLLPC Sbjct: 131 FKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPC 190 Query: 198 GSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEE-----ESFPQP 252 G D+F G EYVCC P +G S E EDEEE+ FP Sbjct: 191 GVDQFHGTEYVCC-------PQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTE 243 Query: 253 VD-DYFVEPPQAEEEEE 268 D + F E E++E+ Sbjct: 244 ADLEDFTEAAVDEDDED 260 >gi|214010185 amyloid beta (A4) precursor-like protein 2 isoform 4 [Homo sapiens] Length = 522 Score = 301 bits (772), Expect = 1e-81 Identities = 171/386 (44%), Positives = 238/386 (61%), Gaps = 21/386 (5%) Query: 284 VTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLP 343 V PTP PT+ VD+YF + +EH F +AK LE R +++ V +EW A+ Q+KNLP Sbjct: 135 VPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLP 194 Query: 344 KADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADP 403 KA+RQ L +HFQ++++ LE++ + E+Q+LVETH RV A++ND+RR ALE +LAALQ+DP Sbjct: 195 KAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDP 254 Query: 404 PQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQS 463 P+ R+L ALRRY+RAE K++ HT+RHYQHV AVDPEKA QM+ QV THL VIEER NQS Sbjct: 255 PRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQS 314 Query: 464 LGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGG------SSEDKGGLQP--PDS 515 L LL + P++AQE++ +I ELL + + A SSE+ + P P Sbjct: 315 LSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFH 374 Query: 516 KDADTPMTLPKGSTEQDAA----------SPEKEKMNPLEQYERKVNASVPRGFPFHSSE 565 P G EQD S K N + V + E Sbjct: 375 PFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLE 434 Query: 566 IQRDELAP--AGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPM 623 +R+ + P +S A+ GLL++ ++IV+S+++L RK+ YG ISHG+VEVDPM Sbjct: 435 EERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVML-RKRQYGTISHGIVEVDPM 493 Query: 624 LTLEEQQLRELQRHGYENPTYRFLEE 649 LT EE+ L ++Q HGYENPTY++LE+ Sbjct: 494 LTPEERHLNKMQNHGYENPTYKYLEQ 519 Score = 90.9 bits (224), Expect = 3e-18 Identities = 48/124 (38%), Positives = 70/124 (56%), Gaps = 10/124 (8%) Query: 24 LPLLLLLLRAQPAIGSLAG------GSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPD 77 L LLLL+ PA+ +LAG + G A Q+A CG+L +H +++TG+WEPD Sbjct: 15 LLLLLLVGLTAPAL-ALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPD 73 Query: 78 PQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVP 137 P ++ C + VL+YC++MYPELQI V +A Q + ++ WC R V P Sbjct: 74 PTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWC---RRDKKQCKSRFVTP 130 Query: 138 FRCL 141 F+CL Sbjct: 131 FKCL 134 >gi|214010181 amyloid beta (A4) precursor-like protein 2 isoform 2 [Homo sapiens] Length = 751 Score = 301 bits (771), Expect = 1e-81 Identities = 170/386 (44%), Positives = 238/386 (61%), Gaps = 21/386 (5%) Query: 284 VTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLP 343 + PTP PT+ VD+YF + +EH F +AK LE R +++ V +EW A+ Q+KNLP Sbjct: 364 IPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLP 423 Query: 344 KADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADP 403 KA+RQ L +HFQ++++ LE++ + E+Q+LVETH RV A++ND+RR ALE +LAALQ+DP Sbjct: 424 KAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDP 483 Query: 404 PQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQS 463 P+ R+L ALRRY+RAE K++ HT+RHYQHV AVDPEKA QM+ QV THL VIEER NQS Sbjct: 484 PRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQS 543 Query: 464 LGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGG------SSEDKGGLQP--PDS 515 L LL + P++AQE++ +I ELL + + A SSE+ + P P Sbjct: 544 LSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFH 603 Query: 516 KDADTPMTLPKGSTEQDAA----------SPEKEKMNPLEQYERKVNASVPRGFPFHSSE 565 P G EQD S K N + V + E Sbjct: 604 PFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLE 663 Query: 566 IQRDELAP--AGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPM 623 +R+ + P +S A+ GLL++ ++IV+S+++L RK+ YG ISHG+VEVDPM Sbjct: 664 EERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVML-RKRQYGTISHGIVEVDPM 722 Query: 624 LTLEEQQLRELQRHGYENPTYRFLEE 649 LT EE+ L ++Q HGYENPTY++LE+ Sbjct: 723 LTPEERHLNKMQNHGYENPTYKYLEQ 748 Score = 188 bits (478), Expect = 1e-47 Identities = 104/257 (40%), Positives = 143/257 (55%), Gaps = 23/257 (8%) Query: 24 LPLLLLLLRAQPAIGSLAG------GSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPD 77 L LLLL+ PA+ +LAG + G A Q+A CG+L +H +++TG+WEPD Sbjct: 15 LLLLLLVGLTAPAL-ALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPD 73 Query: 78 PQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVP 137 P ++ C + VL+YC++MYPELQI V +A Q + ++ WC + C V P Sbjct: 74 PTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKK-QCKSRF--VTP 130 Query: 138 FRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPC 197 F+CL GEFVS+ LLVPE C+F H+ERM+ CE+ H +EAC +QG+ L+ GMLLPC Sbjct: 131 FKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPC 190 Query: 198 GSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEE-----ESFPQP 252 G D+F G EYVCC P +G S E EDEEE+ FP Sbjct: 191 GVDQFHGTEYVCC-------PQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTE 243 Query: 253 VD-DYFVEPPQAEEEEE 268 D + F E E++E+ Sbjct: 244 ADLEDFTEAAVDEDDED 260 >gi|4502167 amyloid beta A4 protein isoform a precursor [Homo sapiens] Length = 770 Score = 257 bits (657), Expect = 2e-68 Identities = 157/401 (39%), Positives = 234/401 (58%), Gaps = 49/401 (12%) Query: 292 DGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALN 351 D VD Y PG+ +EH F +AK LE + ++++VMREW A+ Q+KNLPKAD++A+ Sbjct: 373 DAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVI 432 Query: 352 EHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLL 411 +HFQ +++LE++ + ERQ+LVETH RV A++ND+RR ALE ++ ALQA PP+ V Sbjct: 433 QHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFN 492 Query: 412 ALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNP 471 L++Y+RAEQK+++HTL+H++HV VDP+KA Q+R QV THL+VI ER+NQSL LL P Sbjct: 493 MLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVP 552 Query: 472 HLAQELRPQIQELLHSEH----------------------LGPSELEA-------PAPGG 502 +A+E++ ++ ELL E L PS E P G Sbjct: 553 AVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGE 612 Query: 503 SSEDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEK------------MNPLEQYERK 550 S D LQP S AD+ + E A P ++ + E E K Sbjct: 613 FSLD--DLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVK 670 Query: 551 VNASV--PRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKK 608 ++A G+ H Q+ G ++ A+ GL++ G ++IV+++++L +KK Sbjct: 671 MDAEFRHDSGYEVHH---QKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVML-KKK 726 Query: 609 PYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEE 649 Y +I HGVVEVD +T EE+ L ++Q++GYENPTY+F E+ Sbjct: 727 QYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQ 767 Score = 210 bits (535), Expect = 3e-54 Identities = 157/488 (32%), Positives = 232/488 (47%), Gaps = 53/488 (10%) Query: 23 LLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSR 82 +LP L LLL A +L + G A Q+A CGRL +H +++ G+W+ DP ++ Sbjct: 1 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60 Query: 83 RCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLP 142 C+ + +L+YC+++YPELQI V +A Q + ++ WC R HPH V+P+RCL Sbjct: 61 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHF-VIPYRCLV 119 Query: 143 GEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRF 202 GEFVS+ALLVP+ C+FLHQERMD CE+ H A+E CS + LH GMLLPCG D+F Sbjct: 120 GEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKF 179 Query: 203 RGVEYVCCPPPGTPD--PSGTAVGDPSTRSW-------PPGSR---VEGAEDEEEEESFP 250 RGVE+VCCP D S A D S W GS VE AE+EE E Sbjct: 180 RGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEE 239 Query: 251 QPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGF 310 + DD + E EEE P T T T T+ V+ G Sbjct: 240 EEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGP 299 Query: 311 LRAKM-----DLEERRM----------RQINEVMREWAMADNQSKNLPKADRQALNEHFQ 355 RA + D+ E + + N E+ MA S A++ Q Sbjct: 300 CRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGS---------AMS---Q 347 Query: 356 SILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQ-----ADPPQAERVL 410 S+L+T +E ++ + +L T A+ A+ E A Q + ER+ Sbjct: 348 SLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMS 407 Query: 411 LALRRYLRAEQK-------EQRHTLRHYQH-VAAVDPEKAQQMRFQVHTHLQVIEERVNQ 462 +R + AE++ +++ ++H+Q V +++ E A + + V TH+ +E +N Sbjct: 408 QVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLND 467 Query: 463 SLGLLDQN 470 L +N Sbjct: 468 RRRLALEN 475 >gi|209915573 amyloid beta A4 protein isoform f precursor [Homo sapiens] Length = 714 Score = 257 bits (657), Expect = 2e-68 Identities = 157/401 (39%), Positives = 234/401 (58%), Gaps = 49/401 (12%) Query: 292 DGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALN 351 D VD Y PG+ +EH F +AK LE + ++++VMREW A+ Q+KNLPKAD++A+ Sbjct: 317 DAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVI 376 Query: 352 EHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLL 411 +HFQ +++LE++ + ERQ+LVETH RV A++ND+RR ALE ++ ALQA PP+ V Sbjct: 377 QHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFN 436 Query: 412 ALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNP 471 L++Y+RAEQK+++HTL+H++HV VDP+KA Q+R QV THL+VI ER+NQSL LL P Sbjct: 437 MLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVP 496 Query: 472 HLAQELRPQIQELLHSEH----------------------LGPSELEA-------PAPGG 502 +A+E++ ++ ELL E L PS E P G Sbjct: 497 AVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGE 556 Query: 503 SSEDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEK------------MNPLEQYERK 550 S D LQP S AD+ + E A P ++ + E E K Sbjct: 557 FSLD--DLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVK 614 Query: 551 VNASV--PRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKK 608 ++A G+ H Q+ G ++ A+ GL++ G ++IV+++++L +KK Sbjct: 615 MDAEFRHDSGYEVHH---QKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVML-KKK 670 Query: 609 PYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEE 649 Y +I HGVVEVD +T EE+ L ++Q++GYENPTY+F E+ Sbjct: 671 QYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQ 711 Score = 160 bits (406), Expect = 3e-39 Identities = 132/414 (31%), Positives = 190/414 (45%), Gaps = 53/414 (12%) Query: 97 QMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGC 156 ++YPELQI V +A Q + ++ WC R HPH V+P+RCL GEFVS+ALLVP+ C Sbjct: 19 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHF-VIPYRCLVGEFVSDALLVPDKC 77 Query: 157 RFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTP 216 +FLHQERMD CE+ H A+E CS + LH GMLLPCG D+FRGVE+VCCP Sbjct: 78 KFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEES 137 Query: 217 D--PSGTAVGDPSTRSW-------PPGSR---VEGAEDEEEEESFPQPVDDYFVEPPQAE 264 D S A D S W GS VE AE+EE E + DD + E Sbjct: 138 DNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDE 197 Query: 265 EEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKM-----DLEE 319 EEE P T T T T+ V+ G RA + D+ E Sbjct: 198 VEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTE 257 Query: 320 RRM----------RQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGER 369 + + N E+ MA S A++ QS+L+T +E ++ + Sbjct: 258 GKCAPFFYGGCGGNRNNFDTEEYCMAVCGS---------AMS---QSLLKTTQEPLARDP 305 Query: 370 QRLVETHATRVIALINDQRRAALEGFLAALQ-----ADPPQAERVLLALRRYLRAEQK-- 422 +L T A+ A+ E A Q + ER+ +R + AE++ Sbjct: 306 VKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAK 365 Query: 423 -----EQRHTLRHYQH-VAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQN 470 +++ ++H+Q V +++ E A + + V TH+ +E +N L +N Sbjct: 366 NLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALEN 419 >gi|91208420 bassoon protein [Homo sapiens] Length = 3926 Score = 45.1 bits (105), Expect = 2e-04 Identities = 43/172 (25%), Positives = 70/172 (40%), Gaps = 18/172 (10%) Query: 444 QMRFQVHTHLQVIEE------RVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEA 497 Q F + HL ++E ++ ++LG+ + R + Q+ LHS L P+ A Sbjct: 200 QCGFNPNPHLTQVKEWLCLNCQMQRALGM-----DMTTAPRSKSQQQLHSPALSPAHSPA 254 Query: 498 PAPGGSSEDKGGLQP----PDSKDADTPMTLPKGSTEQDAASPEKEKMNPLEQYERKVNA 553 P G + + P P S+ A+T Q AA PE +++P K + Sbjct: 255 KQPLGKPDQERSRGPGGPQPGSRQAETARATSVPGPAQAAAPPEVGRVSPQPPQPTKPST 314 Query: 554 SVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLL--IMGAGGGSLIVLSMLL 603 + PR P + + PAG G + + GL + G G L S L+ Sbjct: 315 AEPRP-PAGEAPAKSATAVPAGLGATEQTQEGLTGKLFGLGASLLTQASTLM 365 Score = 33.5 bits (75), Expect = 0.63 Identities = 41/172 (23%), Positives = 66/172 (38%), Gaps = 16/172 (9%) Query: 362 EEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQ 421 EE ERQR + ++ ++ R LE + + ERV L R + Sbjct: 2357 EEASQEERQRKQQEQLLQL-----ERERVELEKLRQLRLQEELERERVELQRHR-----E 2406 Query: 422 KEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQI 481 +EQ R Q + + QQ + + + E++ Q L+Q L Q+L+ Q+ Sbjct: 2407 EEQLLVQRELQELQTIKHHVLQQQQEERQAQFALQREQLAQQRLQLEQIQQLQQQLQQQL 2466 Query: 482 QELLHSEHLG-PSELEAPAPG-----GSSEDKGGLQPPDSKDADTPMTLPKG 527 +E + P+ EAP G G PP + A M P+G Sbjct: 2467 EEQKQRQKAPFPAACEAPGRGPPLAAAELAQNGQYWPPLTHAAFIAMAGPEG 2518 Score = 30.4 bits (67), Expect = 5.3 Identities = 35/114 (30%), Positives = 47/114 (41%), Gaps = 13/114 (11%) Query: 5 SPAARGLSRRPGQP-------PLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVA 57 +P A G SR P P PLP P + PA LAG P A APG + Sbjct: 2290 APGAGGPSR-PEMPVGAAREEPLPTTTPAAIKEAAGAPAPAPLAGQKPPADAAPGGG--S 2346 Query: 58 GLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQRV-LEYCRQ--MYPELQIARVE 108 G R ++ + Q+ + + +RV LE RQ + EL+ RVE Sbjct: 2347 GALSRPGFEKEEASQEERQRKQQEQLLQLERERVELEKLRQLRLQEELERERVE 2400 >gi|41322923 plectin 1 isoform 11 [Homo sapiens] Length = 4547 Score = 42.0 bits (97), Expect = 0.002 Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 26/243 (10%) Query: 312 RAKMDLEERRMRQ-INEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ 370 R + D + R+R+ I E+ RE ++K L Q +E Q++ Q EQ+ E Q Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLL-----QLKSEEMQTVQQ---EQLLQETQ 2489 Query: 371 RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRH 430 L ++ + +L+ +R F+ +A Q + +A + LR EQ+ Q+ + Sbjct: 2490 ALQQSFLSEKDSLLQRER------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543 Query: 431 YQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHL 490 + E+A++ + + ++ +E + Q L+Q +EL + + L E L Sbjct: 2544 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLR-EQL 2598 Query: 491 GPSELEAPAPGGSSEDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEKMNPLEQYERK 550 E + A SE+ Q +K TLP G D + E E + + RK Sbjct: 2599 QLLEEQHRAALAHSEEVTASQVAATK------TLPNGRDALDGPAAEAEPEHSFDGLRRK 2652 Query: 551 VNA 553 V+A Sbjct: 2653 VSA 2655 Score = 38.1 bits (87), Expect = 0.026 Identities = 47/194 (24%), Positives = 74/194 (38%), Gaps = 17/194 (8%) Query: 306 EHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEE-- 363 E E R + ER RQ+ + + A+ + + KA+ +A E Q LQ LEE Sbjct: 1484 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELR 1542 Query: 364 -QVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQK 422 Q +RL + R Q + ALE + +A+ L +R AE+ Sbjct: 1543 LQAEEAERRLRQAEVERA-----RQVQVALETAQRSAEAE--------LQSKRASFAEKT 1589 Query: 423 EQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQ 482 Q +HVA + + R Q + E + L + A LR Q + Sbjct: 1590 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1649 Query: 483 ELLHSEHLGPSELE 496 E+ + L +E E Sbjct: 1650 EVAQQKSLAQAEAE 1663 Score = 35.8 bits (81), Expect = 0.13 Identities = 41/160 (25%), Positives = 70/160 (43%), Gaps = 17/160 (10%) Query: 312 RAKMDLEERRMRQINEVMR--EWAMADNQSKNLPKADRQALNEHFQSILQTLEEQV-SGE 368 +A+ + +E + R EV+R E A+ Q K + + Q L + ++ +Q Q + E Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1444 Query: 369 RQRLVETHATRVIAL---INDQRRAALEGFLAAL-------QADPPQAERVLLALRRYLR 418 R RL RV+ L +++R EG L AL +A QA+ LRR ++ Sbjct: 1445 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1504 Query: 419 AEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEE 458 E + +R + E A++ + LQ +EE Sbjct: 1505 DESQRKRQAEVELASRVKAEAEAAREKQ----RALQALEE 1540 Score = 33.5 bits (75), Expect = 0.63 Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 25/204 (12%) Query: 311 LRAKMDLEERRMRQI--NEVMREWAMADNQSKNLPKADRQA----LNEHFQSILQTLEEQ 364 L+AK++ E RR+R+ E R+ +A ++ +A+ +A + + Q + QTL+++ Sbjct: 2014 LKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2072 Query: 365 VSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRA----- 419 S Q E A R A ++ R E A + +AER+ + +A Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2132 Query: 420 -------EQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPH 472 ++ EQ R AA+ ++A + H ++ Q+L Q Sbjct: 2133 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH------KKFAEQTLRQKAQVEQ 2186 Query: 473 LAQELRPQIQELLHSEHLGPSELE 496 LR Q++E H ++L EL+ Sbjct: 2187 ELTTLRLQLEETDHQKNLLDEELQ 2210 >gi|41322914 plectin 1 isoform 10 [Homo sapiens] Length = 4551 Score = 42.0 bits (97), Expect = 0.002 Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 26/243 (10%) Query: 312 RAKMDLEERRMRQ-INEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ 370 R + D + R+R+ I E+ RE ++K L Q +E Q++ Q EQ+ E Q Sbjct: 2442 RQQSDHDAERLREAIAELEREKEKLQQEAKLL-----QLKSEEMQTVQQ---EQLLQETQ 2493 Query: 371 RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRH 430 L ++ + +L+ +R F+ +A Q + +A + LR EQ+ Q+ + Sbjct: 2494 ALQQSFLSEKDSLLQRER------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2547 Query: 431 YQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHL 490 + E+A++ + + ++ +E + Q L+Q +EL + + L E L Sbjct: 2548 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLR-EQL 2602 Query: 491 GPSELEAPAPGGSSEDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEKMNPLEQYERK 550 E + A SE+ Q +K TLP G D + E E + + RK Sbjct: 2603 QLLEEQHRAALAHSEEVTASQVAATK------TLPNGRDALDGPAAEAEPEHSFDGLRRK 2656 Query: 551 VNA 553 V+A Sbjct: 2657 VSA 2659 Score = 38.1 bits (87), Expect = 0.026 Identities = 47/194 (24%), Positives = 74/194 (38%), Gaps = 17/194 (8%) Query: 306 EHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEE-- 363 E E R + ER RQ+ + + A+ + + KA+ +A E Q LQ LEE Sbjct: 1488 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELR 1546 Query: 364 -QVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQK 422 Q +RL + R Q + ALE + +A+ L +R AE+ Sbjct: 1547 LQAEEAERRLRQAEVERA-----RQVQVALETAQRSAEAE--------LQSKRASFAEKT 1593 Query: 423 EQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQ 482 Q +HVA + + R Q + E + L + A LR Q + Sbjct: 1594 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1653 Query: 483 ELLHSEHLGPSELE 496 E+ + L +E E Sbjct: 1654 EVAQQKSLAQAEAE 1667 Score = 35.8 bits (81), Expect = 0.13 Identities = 41/160 (25%), Positives = 70/160 (43%), Gaps = 17/160 (10%) Query: 312 RAKMDLEERRMRQINEVMR--EWAMADNQSKNLPKADRQALNEHFQSILQTLEEQV-SGE 368 +A+ + +E + R EV+R E A+ Q K + + Q L + ++ +Q Q + E Sbjct: 1389 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1448 Query: 369 RQRLVETHATRVIAL---INDQRRAALEGFLAAL-------QADPPQAERVLLALRRYLR 418 R RL RV+ L +++R EG L AL +A QA+ LRR ++ Sbjct: 1449 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1508 Query: 419 AEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEE 458 E + +R + E A++ + LQ +EE Sbjct: 1509 DESQRKRQAEVELASRVKAEAEAAREKQ----RALQALEE 1544 Score = 33.5 bits (75), Expect = 0.63 Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 25/204 (12%) Query: 311 LRAKMDLEERRMRQI--NEVMREWAMADNQSKNLPKADRQA----LNEHFQSILQTLEEQ 364 L+AK++ E RR+R+ E R+ +A ++ +A+ +A + + Q + QTL+++ Sbjct: 2018 LKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2076 Query: 365 VSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRA----- 419 S Q E A R A ++ R E A + +AER+ + +A Sbjct: 2077 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2136 Query: 420 -------EQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPH 472 ++ EQ R AA+ ++A + H ++ Q+L Q Sbjct: 2137 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH------KKFAEQTLRQKAQVEQ 2190 Query: 473 LAQELRPQIQELLHSEHLGPSELE 496 LR Q++E H ++L EL+ Sbjct: 2191 ELTTLRLQLEETDHQKNLLDEELQ 2214 >gi|41322919 plectin 1 isoform 8 [Homo sapiens] Length = 4547 Score = 42.0 bits (97), Expect = 0.002 Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 26/243 (10%) Query: 312 RAKMDLEERRMRQ-INEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ 370 R + D + R+R+ I E+ RE ++K L Q +E Q++ Q EQ+ E Q Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLL-----QLKSEEMQTVQQ---EQLLQETQ 2489 Query: 371 RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRH 430 L ++ + +L+ +R F+ +A Q + +A + LR EQ+ Q+ + Sbjct: 2490 ALQQSFLSEKDSLLQRER------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543 Query: 431 YQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHL 490 + E+A++ + + ++ +E + Q L+Q +EL + + L E L Sbjct: 2544 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLR-EQL 2598 Query: 491 GPSELEAPAPGGSSEDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEKMNPLEQYERK 550 E + A SE+ Q +K TLP G D + E E + + RK Sbjct: 2599 QLLEEQHRAALAHSEEVTASQVAATK------TLPNGRDALDGPAAEAEPEHSFDGLRRK 2652 Query: 551 VNA 553 V+A Sbjct: 2653 VSA 2655 Score = 38.1 bits (87), Expect = 0.026 Identities = 47/194 (24%), Positives = 74/194 (38%), Gaps = 17/194 (8%) Query: 306 EHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEE-- 363 E E R + ER RQ+ + + A+ + + KA+ +A E Q LQ LEE Sbjct: 1484 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELR 1542 Query: 364 -QVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQK 422 Q +RL + R Q + ALE + +A+ L +R AE+ Sbjct: 1543 LQAEEAERRLRQAEVERA-----RQVQVALETAQRSAEAE--------LQSKRASFAEKT 1589 Query: 423 EQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQ 482 Q +HVA + + R Q + E + L + A LR Q + Sbjct: 1590 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1649 Query: 483 ELLHSEHLGPSELE 496 E+ + L +E E Sbjct: 1650 EVAQQKSLAQAEAE 1663 Score = 35.8 bits (81), Expect = 0.13 Identities = 41/160 (25%), Positives = 70/160 (43%), Gaps = 17/160 (10%) Query: 312 RAKMDLEERRMRQINEVMR--EWAMADNQSKNLPKADRQALNEHFQSILQTLEEQV-SGE 368 +A+ + +E + R EV+R E A+ Q K + + Q L + ++ +Q Q + E Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1444 Query: 369 RQRLVETHATRVIAL---INDQRRAALEGFLAAL-------QADPPQAERVLLALRRYLR 418 R RL RV+ L +++R EG L AL +A QA+ LRR ++ Sbjct: 1445 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1504 Query: 419 AEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEE 458 E + +R + E A++ + LQ +EE Sbjct: 1505 DESQRKRQAEVELASRVKAEAEAAREKQ----RALQALEE 1540 Score = 33.5 bits (75), Expect = 0.63 Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 25/204 (12%) Query: 311 LRAKMDLEERRMRQI--NEVMREWAMADNQSKNLPKADRQA----LNEHFQSILQTLEEQ 364 L+AK++ E RR+R+ E R+ +A ++ +A+ +A + + Q + QTL+++ Sbjct: 2014 LKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2072 Query: 365 VSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRA----- 419 S Q E A R A ++ R E A + +AER+ + +A Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2132 Query: 420 -------EQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPH 472 ++ EQ R AA+ ++A + H ++ Q+L Q Sbjct: 2133 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH------KKFAEQTLRQKAQVEQ 2186 Query: 473 LAQELRPQIQELLHSEHLGPSELE 496 LR Q++E H ++L EL+ Sbjct: 2187 ELTTLRLQLEETDHQKNLLDEELQ 2210 >gi|41322910 plectin 1 isoform 7 [Homo sapiens] Length = 4515 Score = 42.0 bits (97), Expect = 0.002 Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 26/243 (10%) Query: 312 RAKMDLEERRMRQ-INEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ 370 R + D + R+R+ I E+ RE ++K L Q +E Q++ Q EQ+ E Q Sbjct: 2406 RQQSDHDAERLREAIAELEREKEKLQQEAKLL-----QLKSEEMQTVQQ---EQLLQETQ 2457 Query: 371 RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRH 430 L ++ + +L+ +R F+ +A Q + +A + LR EQ+ Q+ + Sbjct: 2458 ALQQSFLSEKDSLLQRER------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2511 Query: 431 YQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHL 490 + E+A++ + + ++ +E + Q L+Q +EL + + L E L Sbjct: 2512 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLR-EQL 2566 Query: 491 GPSELEAPAPGGSSEDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEKMNPLEQYERK 550 E + A SE+ Q +K TLP G D + E E + + RK Sbjct: 2567 QLLEEQHRAALAHSEEVTASQVAATK------TLPNGRDALDGPAAEAEPEHSFDGLRRK 2620 Query: 551 VNA 553 V+A Sbjct: 2621 VSA 2623 Score = 38.1 bits (87), Expect = 0.026 Identities = 47/194 (24%), Positives = 74/194 (38%), Gaps = 17/194 (8%) Query: 306 EHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEE-- 363 E E R + ER RQ+ + + A+ + + KA+ +A E Q LQ LEE Sbjct: 1452 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELR 1510 Query: 364 -QVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQK 422 Q +RL + R Q + ALE + +A+ L +R AE+ Sbjct: 1511 LQAEEAERRLRQAEVERA-----RQVQVALETAQRSAEAE--------LQSKRASFAEKT 1557 Query: 423 EQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQ 482 Q +HVA + + R Q + E + L + A LR Q + Sbjct: 1558 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1617 Query: 483 ELLHSEHLGPSELE 496 E+ + L +E E Sbjct: 1618 EVAQQKSLAQAEAE 1631 Score = 35.8 bits (81), Expect = 0.13 Identities = 41/160 (25%), Positives = 70/160 (43%), Gaps = 17/160 (10%) Query: 312 RAKMDLEERRMRQINEVMR--EWAMADNQSKNLPKADRQALNEHFQSILQTLEEQV-SGE 368 +A+ + +E + R EV+R E A+ Q K + + Q L + ++ +Q Q + E Sbjct: 1353 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1412 Query: 369 RQRLVETHATRVIAL---INDQRRAALEGFLAAL-------QADPPQAERVLLALRRYLR 418 R RL RV+ L +++R EG L AL +A QA+ LRR ++ Sbjct: 1413 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1472 Query: 419 AEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEE 458 E + +R + E A++ + LQ +EE Sbjct: 1473 DESQRKRQAEVELASRVKAEAEAAREKQ----RALQALEE 1508 Score = 33.5 bits (75), Expect = 0.63 Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 25/204 (12%) Query: 311 LRAKMDLEERRMRQI--NEVMREWAMADNQSKNLPKADRQA----LNEHFQSILQTLEEQ 364 L+AK++ E RR+R+ E R+ +A ++ +A+ +A + + Q + QTL+++ Sbjct: 1982 LKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2040 Query: 365 VSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRA----- 419 S Q E A R A ++ R E A + +AER+ + +A Sbjct: 2041 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2100 Query: 420 -------EQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPH 472 ++ EQ R AA+ ++A + H ++ Q+L Q Sbjct: 2101 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH------KKFAEQTLRQKAQVEQ 2154 Query: 473 LAQELRPQIQELLHSEHLGPSELE 496 LR Q++E H ++L EL+ Sbjct: 2155 ELTTLRLQLEETDHQKNLLDEELQ 2178 >gi|41322916 plectin 1 isoform 6 [Homo sapiens] Length = 4684 Score = 42.0 bits (97), Expect = 0.002 Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 26/243 (10%) Query: 312 RAKMDLEERRMRQ-INEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ 370 R + D + R+R+ I E+ RE ++K L Q +E Q++ Q EQ+ E Q Sbjct: 2575 RQQSDHDAERLREAIAELEREKEKLQQEAKLL-----QLKSEEMQTVQQ---EQLLQETQ 2626 Query: 371 RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRH 430 L ++ + +L+ +R F+ +A Q + +A + LR EQ+ Q+ + Sbjct: 2627 ALQQSFLSEKDSLLQRER------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2680 Query: 431 YQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHL 490 + E+A++ + + ++ +E + Q L+Q +EL + + L E L Sbjct: 2681 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLR-EQL 2735 Query: 491 GPSELEAPAPGGSSEDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEKMNPLEQYERK 550 E + A SE+ Q +K TLP G D + E E + + RK Sbjct: 2736 QLLEEQHRAALAHSEEVTASQVAATK------TLPNGRDALDGPAAEAEPEHSFDGLRRK 2789 Query: 551 VNA 553 V+A Sbjct: 2790 VSA 2792 Score = 38.1 bits (87), Expect = 0.026 Identities = 47/194 (24%), Positives = 74/194 (38%), Gaps = 17/194 (8%) Query: 306 EHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEE-- 363 E E R + ER RQ+ + + A+ + + KA+ +A E Q LQ LEE Sbjct: 1621 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELR 1679 Query: 364 -QVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQK 422 Q +RL + R Q + ALE + +A+ L +R AE+ Sbjct: 1680 LQAEEAERRLRQAEVERA-----RQVQVALETAQRSAEAE--------LQSKRASFAEKT 1726 Query: 423 EQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQ 482 Q +HVA + + R Q + E + L + A LR Q + Sbjct: 1727 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1786 Query: 483 ELLHSEHLGPSELE 496 E+ + L +E E Sbjct: 1787 EVAQQKSLAQAEAE 1800 Score = 35.8 bits (81), Expect = 0.13 Identities = 41/160 (25%), Positives = 70/160 (43%), Gaps = 17/160 (10%) Query: 312 RAKMDLEERRMRQINEVMR--EWAMADNQSKNLPKADRQALNEHFQSILQTLEEQV-SGE 368 +A+ + +E + R EV+R E A+ Q K + + Q L + ++ +Q Q + E Sbjct: 1522 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1581 Query: 369 RQRLVETHATRVIAL---INDQRRAALEGFLAAL-------QADPPQAERVLLALRRYLR 418 R RL RV+ L +++R EG L AL +A QA+ LRR ++ Sbjct: 1582 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1641 Query: 419 AEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEE 458 E + +R + E A++ + LQ +EE Sbjct: 1642 DESQRKRQAEVELASRVKAEAEAAREKQ----RALQALEE 1677 Score = 33.5 bits (75), Expect = 0.63 Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 25/204 (12%) Query: 311 LRAKMDLEERRMRQI--NEVMREWAMADNQSKNLPKADRQA----LNEHFQSILQTLEEQ 364 L+AK++ E RR+R+ E R+ +A ++ +A+ +A + + Q + QTL+++ Sbjct: 2151 LKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2209 Query: 365 VSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRA----- 419 S Q E A R A ++ R E A + +AER+ + +A Sbjct: 2210 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2269 Query: 420 -------EQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPH 472 ++ EQ R AA+ ++A + H ++ Q+L Q Sbjct: 2270 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH------KKFAEQTLRQKAQVEQ 2323 Query: 473 LAQELRPQIQELLHSEHLGPSELE 496 LR Q++E H ++L EL+ Sbjct: 2324 ELTTLRLQLEETDHQKNLLDEELQ 2347 >gi|41322908 plectin 1 isoform 3 [Homo sapiens] Length = 4525 Score = 42.0 bits (97), Expect = 0.002 Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 26/243 (10%) Query: 312 RAKMDLEERRMRQ-INEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ 370 R + D + R+R+ I E+ RE ++K L Q +E Q++ Q EQ+ E Q Sbjct: 2416 RQQSDHDAERLREAIAELEREKEKLQQEAKLL-----QLKSEEMQTVQQ---EQLLQETQ 2467 Query: 371 RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRH 430 L ++ + +L+ +R F+ +A Q + +A + LR EQ+ Q+ + Sbjct: 2468 ALQQSFLSEKDSLLQRER------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2521 Query: 431 YQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHL 490 + E+A++ + + ++ +E + Q L+Q +EL + + L E L Sbjct: 2522 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLR-EQL 2576 Query: 491 GPSELEAPAPGGSSEDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEKMNPLEQYERK 550 E + A SE+ Q +K TLP G D + E E + + RK Sbjct: 2577 QLLEEQHRAALAHSEEVTASQVAATK------TLPNGRDALDGPAAEAEPEHSFDGLRRK 2630 Query: 551 VNA 553 V+A Sbjct: 2631 VSA 2633 Score = 38.1 bits (87), Expect = 0.026 Identities = 47/194 (24%), Positives = 74/194 (38%), Gaps = 17/194 (8%) Query: 306 EHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEE-- 363 E E R + ER RQ+ + + A+ + + KA+ +A E Q LQ LEE Sbjct: 1462 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELR 1520 Query: 364 -QVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQK 422 Q +RL + R Q + ALE + +A+ L +R AE+ Sbjct: 1521 LQAEEAERRLRQAEVERA-----RQVQVALETAQRSAEAE--------LQSKRASFAEKT 1567 Query: 423 EQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQ 482 Q +HVA + + R Q + E + L + A LR Q + Sbjct: 1568 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1627 Query: 483 ELLHSEHLGPSELE 496 E+ + L +E E Sbjct: 1628 EVAQQKSLAQAEAE 1641 Score = 35.8 bits (81), Expect = 0.13 Identities = 41/160 (25%), Positives = 70/160 (43%), Gaps = 17/160 (10%) Query: 312 RAKMDLEERRMRQINEVMR--EWAMADNQSKNLPKADRQALNEHFQSILQTLEEQV-SGE 368 +A+ + +E + R EV+R E A+ Q K + + Q L + ++ +Q Q + E Sbjct: 1363 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1422 Query: 369 RQRLVETHATRVIAL---INDQRRAALEGFLAAL-------QADPPQAERVLLALRRYLR 418 R RL RV+ L +++R EG L AL +A QA+ LRR ++ Sbjct: 1423 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1482 Query: 419 AEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEE 458 E + +R + E A++ + LQ +EE Sbjct: 1483 DESQRKRQAEVELASRVKAEAEAAREKQ----RALQALEE 1518 Score = 33.5 bits (75), Expect = 0.63 Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 25/204 (12%) Query: 311 LRAKMDLEERRMRQI--NEVMREWAMADNQSKNLPKADRQA----LNEHFQSILQTLEEQ 364 L+AK++ E RR+R+ E R+ +A ++ +A+ +A + + Q + QTL+++ Sbjct: 1992 LKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2050 Query: 365 VSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRA----- 419 S Q E A R A ++ R E A + +AER+ + +A Sbjct: 2051 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2110 Query: 420 -------EQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPH 472 ++ EQ R AA+ ++A + H ++ Q+L Q Sbjct: 2111 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH------KKFAEQTLRQKAQVEQ 2164 Query: 473 LAQELRPQIQELLHSEHLGPSELE 496 LR Q++E H ++L EL+ Sbjct: 2165 ELTTLRLQLEETDHQKNLLDEELQ 2188 >gi|41322912 plectin 1 isoform 2 [Homo sapiens] Length = 4533 Score = 42.0 bits (97), Expect = 0.002 Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 26/243 (10%) Query: 312 RAKMDLEERRMRQ-INEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ 370 R + D + R+R+ I E+ RE ++K L Q +E Q++ Q EQ+ E Q Sbjct: 2424 RQQSDHDAERLREAIAELEREKEKLQQEAKLL-----QLKSEEMQTVQQ---EQLLQETQ 2475 Query: 371 RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRH 430 L ++ + +L+ +R F+ +A Q + +A + LR EQ+ Q+ + Sbjct: 2476 ALQQSFLSEKDSLLQRER------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2529 Query: 431 YQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHL 490 + E+A++ + + ++ +E + Q L+Q +EL + + L E L Sbjct: 2530 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLR-EQL 2584 Query: 491 GPSELEAPAPGGSSEDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEKMNPLEQYERK 550 E + A SE+ Q +K TLP G D + E E + + RK Sbjct: 2585 QLLEEQHRAALAHSEEVTASQVAATK------TLPNGRDALDGPAAEAEPEHSFDGLRRK 2638 Query: 551 VNA 553 V+A Sbjct: 2639 VSA 2641 Score = 38.1 bits (87), Expect = 0.026 Identities = 47/194 (24%), Positives = 74/194 (38%), Gaps = 17/194 (8%) Query: 306 EHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEE-- 363 E E R + ER RQ+ + + A+ + + KA+ +A E Q LQ LEE Sbjct: 1470 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELR 1528 Query: 364 -QVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQK 422 Q +RL + R Q + ALE + +A+ L +R AE+ Sbjct: 1529 LQAEEAERRLRQAEVERA-----RQVQVALETAQRSAEAE--------LQSKRASFAEKT 1575 Query: 423 EQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQ 482 Q +HVA + + R Q + E + L + A LR Q + Sbjct: 1576 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1635 Query: 483 ELLHSEHLGPSELE 496 E+ + L +E E Sbjct: 1636 EVAQQKSLAQAEAE 1649 Score = 35.8 bits (81), Expect = 0.13 Identities = 41/160 (25%), Positives = 70/160 (43%), Gaps = 17/160 (10%) Query: 312 RAKMDLEERRMRQINEVMR--EWAMADNQSKNLPKADRQALNEHFQSILQTLEEQV-SGE 368 +A+ + +E + R EV+R E A+ Q K + + Q L + ++ +Q Q + E Sbjct: 1371 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1430 Query: 369 RQRLVETHATRVIAL---INDQRRAALEGFLAAL-------QADPPQAERVLLALRRYLR 418 R RL RV+ L +++R EG L AL +A QA+ LRR ++ Sbjct: 1431 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1490 Query: 419 AEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEE 458 E + +R + E A++ + LQ +EE Sbjct: 1491 DESQRKRQAEVELASRVKAEAEAAREKQ----RALQALEE 1526 Score = 33.5 bits (75), Expect = 0.63 Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 25/204 (12%) Query: 311 LRAKMDLEERRMRQI--NEVMREWAMADNQSKNLPKADRQA----LNEHFQSILQTLEEQ 364 L+AK++ E RR+R+ E R+ +A ++ +A+ +A + + Q + QTL+++ Sbjct: 2000 LKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2058 Query: 365 VSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRA----- 419 S Q E A R A ++ R E A + +AER+ + +A Sbjct: 2059 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2118 Query: 420 -------EQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPH 472 ++ EQ R AA+ ++A + H ++ Q+L Q Sbjct: 2119 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH------KKFAEQTLRQKAQVEQ 2172 Query: 473 LAQELRPQIQELLHSEHLGPSELE 496 LR Q++E H ++L EL+ Sbjct: 2173 ELTTLRLQLEETDHQKNLLDEELQ 2196 >gi|47607492 plectin 1 isoform 1 [Homo sapiens] Length = 4574 Score = 42.0 bits (97), Expect = 0.002 Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 26/243 (10%) Query: 312 RAKMDLEERRMRQ-INEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ 370 R + D + R+R+ I E+ RE ++K L Q +E Q++ Q EQ+ E Q Sbjct: 2465 RQQSDHDAERLREAIAELEREKEKLQQEAKLL-----QLKSEEMQTVQQ---EQLLQETQ 2516 Query: 371 RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRH 430 L ++ + +L+ +R F+ +A Q + +A + LR EQ+ Q+ + Sbjct: 2517 ALQQSFLSEKDSLLQRER------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2570 Query: 431 YQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHL 490 + E+A++ + + ++ +E + Q L+Q +EL + + L E L Sbjct: 2571 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLR-EQL 2625 Query: 491 GPSELEAPAPGGSSEDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEKMNPLEQYERK 550 E + A SE+ Q +K TLP G D + E E + + RK Sbjct: 2626 QLLEEQHRAALAHSEEVTASQVAATK------TLPNGRDALDGPAAEAEPEHSFDGLRRK 2679 Query: 551 VNA 553 V+A Sbjct: 2680 VSA 2682 Score = 38.1 bits (87), Expect = 0.026 Identities = 47/194 (24%), Positives = 74/194 (38%), Gaps = 17/194 (8%) Query: 306 EHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEE-- 363 E E R + ER RQ+ + + A+ + + KA+ +A E Q LQ LEE Sbjct: 1511 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELR 1569 Query: 364 -QVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQK 422 Q +RL + R Q + ALE + +A+ L +R AE+ Sbjct: 1570 LQAEEAERRLRQAEVERA-----RQVQVALETAQRSAEAE--------LQSKRASFAEKT 1616 Query: 423 EQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQ 482 Q +HVA + + R Q + E + L + A LR Q + Sbjct: 1617 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1676 Query: 483 ELLHSEHLGPSELE 496 E+ + L +E E Sbjct: 1677 EVAQQKSLAQAEAE 1690 Score = 35.8 bits (81), Expect = 0.13 Identities = 41/160 (25%), Positives = 70/160 (43%), Gaps = 17/160 (10%) Query: 312 RAKMDLEERRMRQINEVMR--EWAMADNQSKNLPKADRQALNEHFQSILQTLEEQV-SGE 368 +A+ + +E + R EV+R E A+ Q K + + Q L + ++ +Q Q + E Sbjct: 1412 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1471 Query: 369 RQRLVETHATRVIAL---INDQRRAALEGFLAAL-------QADPPQAERVLLALRRYLR 418 R RL RV+ L +++R EG L AL +A QA+ LRR ++ Sbjct: 1472 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1531 Query: 419 AEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEE 458 E + +R + E A++ + LQ +EE Sbjct: 1532 DESQRKRQAEVELASRVKAEAEAAREKQ----RALQALEE 1567 Score = 33.5 bits (75), Expect = 0.63 Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 25/204 (12%) Query: 311 LRAKMDLEERRMRQI--NEVMREWAMADNQSKNLPKADRQA----LNEHFQSILQTLEEQ 364 L+AK++ E RR+R+ E R+ +A ++ +A+ +A + + Q + QTL+++ Sbjct: 2041 LKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2099 Query: 365 VSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRA----- 419 S Q E A R A ++ R E A + +AER+ + +A Sbjct: 2100 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2159 Query: 420 -------EQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPH 472 ++ EQ R AA+ ++A + H ++ Q+L Q Sbjct: 2160 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH------KKFAEQTLRQKAQVEQ 2213 Query: 473 LAQELRPQIQELLHSEHLGPSELE 496 LR Q++E H ++L EL+ Sbjct: 2214 ELTTLRLQLEETDHQKNLLDEELQ 2237 >gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sapiens] Length = 1352 Score = 40.8 bits (94), Expect = 0.004 Identities = 56/219 (25%), Positives = 92/219 (42%), Gaps = 17/219 (7%) Query: 300 MPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQ 359 +PGE + FLR ++ +ER +E +R + Q +N + RQ L E + I Sbjct: 344 LPGESTLRRDFLRLQLANKER-----SEALRRQQLEQQQREN-EEHKRQLLAERQKRI-- 395 Query: 360 TLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPP--QAERVLLALRRYL 417 EEQ E++R +E R L Q R + ++ + +AE +RR L Sbjct: 396 --EEQ--KEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQL 451 Query: 418 RAEQKEQRHTLRHYQHVAAVDPE-KAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQE 476 EQ++ + H A+ E K +Q+ Q + ++ ++ Q L H QE Sbjct: 452 EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQ--RQAERLQRQLKQERDYLVSLQHQRQE 509 Query: 477 LRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDS 515 RP ++ L+ G S E PA E++ L S Sbjct: 510 QRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSS 548 >gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sapiens] Length = 1360 Score = 40.8 bits (94), Expect = 0.004 Identities = 56/219 (25%), Positives = 92/219 (42%), Gaps = 17/219 (7%) Query: 300 MPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQ 359 +PGE + FLR ++ +ER +E +R + Q +N + RQ L E + I Sbjct: 344 LPGESTLRRDFLRLQLANKER-----SEALRRQQLEQQQREN-EEHKRQLLAERQKRI-- 395 Query: 360 TLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPP--QAERVLLALRRYL 417 EEQ E++R +E R L Q R + ++ + +AE +RR L Sbjct: 396 --EEQ--KEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQL 451 Query: 418 RAEQKEQRHTLRHYQHVAAVDPE-KAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQE 476 EQ++ + H A+ E K +Q+ Q + ++ ++ Q L H QE Sbjct: 452 EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQ--RQAERLQRQLKQERDYLVSLQHQRQE 509 Query: 477 LRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDS 515 RP ++ L+ G S E PA E++ L S Sbjct: 510 QRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSS 548 >gi|138175817 zinc finger protein 236 [Homo sapiens] Length = 1845 Score = 40.8 bits (94), Expect = 0.004 Identities = 40/166 (24%), Positives = 74/166 (44%), Gaps = 24/166 (14%) Query: 411 LALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQV-IE-ERVNQSLGLLD 468 L +++++ + E L+ +Q A++D Q Q T +QV IE + + Q+ ++ Sbjct: 754 LNCKKHMKTHRYELAQQLQQHQQAASIDDSTVDQQSMQASTQMQVEIESDELPQTAEVVA 813 Query: 469 QNPHLAQELRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDADTPMTLPKGS 528 NP +L P Q ++ +E G + A P + ED G + P D P+ +G Sbjct: 814 ANPEAMLDLEP--QHVVGTEEAGLGQQLADQPLEADED-GFVAPQD------PL---RGH 861 Query: 529 TEQ-DAASPEKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAP 573 +Q + SP ++ P A +P+GF + Q+ + P Sbjct: 862 VDQFEEQSPAQQSFEP---------AGLPQGFTVTDTYHQQPQFPP 898 >gi|209862789 microtubule associated monoxygenase, calponin and LIM domain containing 3 isoform 1 [Homo sapiens] Length = 2002 Score = 40.4 bits (93), Expect = 0.005 Identities = 38/137 (27%), Positives = 52/137 (37%), Gaps = 11/137 (8%) Query: 175 QEAQEACSSQGLILHGSGM-LLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPP 233 +E +E SS GL LHGS + GS F + PP +P P +P+T Sbjct: 1417 EERRELSSSSGLGLHGSSSNMKTLGSQSFNTSDSAMLTPPSSPPPPPPPGEEPAT----- 1471 Query: 234 GSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDG 293 R + E E P P+ ++ PP+ E PP + V V P D Sbjct: 1472 -LRRKLREAEPNASVVPPPLPATWMRPPR----EPAQPPREEVRKSFVESVEEIPFADDV 1526 Query: 294 VDIYFGMPGEISEHEGF 310 D Y + S E F Sbjct: 1527 EDTYDDKTEDSSLQEKF 1543 >gi|32484977 angiomotin like 2 [Homo sapiens] Length = 780 Score = 40.4 bits (93), Expect = 0.005 Identities = 53/205 (25%), Positives = 83/205 (40%), Gaps = 42/205 (20%) Query: 308 EGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHF--QSILQTLEEQV 365 E +R KMD E RR++ N +RE + N+ + QA ++ + + Q+ E+Q Sbjct: 373 EKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQ- 431 Query: 366 SGERQRLVETHATRVIALINDQRRAA--LEGFLAALQADPPQAERVLLALRRYLRAEQKE 423 + Q +E + I DQRR A LE L Q +AE L + Y+ ++ Sbjct: 432 --QEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERL 489 Query: 424 QRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQE 483 Q+ L Q EK +Q+ ++ T L+ QEL+ Sbjct: 490 QQ-ALGQLQAAC----EKREQLELRLRTRLE--------------------QELKA---- 520 Query: 484 LLHSEHLGPSELEAPAPGGSSEDKG 508 L + +A APGGSS G Sbjct: 521 ------LRAQQRQAGAPGGSSGSGG 539 >gi|33356148 formin-like 1 [Homo sapiens] Length = 1100 Score = 40.0 bits (92), Expect = 0.007 Identities = 69/300 (23%), Positives = 114/300 (38%), Gaps = 44/300 (14%) Query: 211 PPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETV 270 PPP P P G PS + PP + + E P P + PP Sbjct: 542 PPPPPPLP-----GLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPP------ 590 Query: 271 PPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFL----RAKMDLEER-RMRQI 325 PPP T V P P P G G P + + L +AK ++ + RM + Sbjct: 591 PPPPPGTDGPVPPPPPPPPPPPG-----GPPDALGRRDSELGPGVKAKKPIQTKFRMPLL 645 Query: 326 NEVMREWAMAD-------NQSKNLPKADRQALNEHFQ----------SILQTLEEQVSGE 368 N V + + N K L + D E F+ S L++ Q + Sbjct: 646 NWVALKPSQITGTVFTELNDEKVLQELDMSDFEEQFKTKSQGPSLDLSALKSKAAQKAPS 705 Query: 369 RQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERV--LLALRRYLRAEQKEQRH 426 + L+E + + +A+ + E A++A QA + L L R+L E +R Sbjct: 706 KATLIEANRAKNLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEY--ERS 763 Query: 427 TLRHYQHVAAVDPEKAQQMRFQV-HTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELL 485 + ++ E +++ RF + + + + ER+ +L L P AQ L PQ+ ++ Sbjct: 764 LITRFEREQRPMEELSEEDRFMLCFSRIPRLPERMT-TLTFLGNFPDTAQLLMPQLNAII 822 >gi|115648142 centrosomal protein 164kDa [Homo sapiens] Length = 1460 Score = 39.7 bits (91), Expect = 0.009 Identities = 50/203 (24%), Positives = 87/203 (42%), Gaps = 30/203 (14%) Query: 311 LRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGER- 369 L+ ++ EE RMR+ W A QS +AD + ++ LQ L E++ ++ Sbjct: 651 LQKAIEEEEARMREEESQRLSWLRAQVQSST--QADEDQIRAEQEASLQKLREELESQQK 708 Query: 370 --QRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHT 427 + +E +++ + ++ A+ + AAL A E+ L LR L E+KE T Sbjct: 709 AERASLEQKNRQMLEQLKEEIEASEKSEQAALNA---AKEKALQQLREQLEGERKEAVAT 765 Query: 428 L-----------------RHYQHVAAVD---PEKAQQMRFQVHTHLQVIEERVNQ-SLGL 466 L +H + V+++ E Q+ Q+ L +E RV+Q S + Sbjct: 766 LEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHV 825 Query: 467 LDQNPHLAQELRPQIQELLHSEH 489 L+ LR + QE + EH Sbjct: 826 AGYEHELSSLLREKRQE-VEGEH 847 Score = 38.9 bits (89), Expect = 0.015 Identities = 39/161 (24%), Positives = 66/161 (40%), Gaps = 12/161 (7%) Query: 264 EEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMR 323 EEEE + S L+ + + D I + + L ++ E + Sbjct: 656 EEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLE 715 Query: 324 QINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIAL 383 Q N M E + ++ K+++ ALN + LQ L EQ+ GER+ V T Sbjct: 716 QKNRQMLEQLKEEIEASE--KSEQAALNAAKEKALQQLREQLEGERKEAVAT-------- 765 Query: 384 INDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQ 424 + + A LE ++L+A E V ++ A+QKE+ Sbjct: 766 LEKEHSAELERLCSSLEA--KHREVVSSLQKKIQEAQQKEE 804 Score = 29.6 bits (65), Expect = 9.1 Identities = 38/158 (24%), Positives = 64/158 (40%), Gaps = 23/158 (14%) Query: 352 EH-FQSILQTLEEQVSGERQR----LVETHATRVIALINDQ-------RRAALEGFLAAL 399 EH S+L+ ++V GE +R + E H +V+A +Q +RA L G L Sbjct: 829 EHELSSLLREKRQEVEGEHERRLDKMKEEHQ-QVMAKAREQYEAEERKQRAELLGHLTG- 886 Query: 400 QADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEER 459 + ER+ A R L ++EQ L + K Q + + T + ++ R Sbjct: 887 -----ELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKAR 941 Query: 460 VNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEA 497 L LL+ A+ + Q+ ++ L E A Sbjct: 942 ----LALLEVQEETARREKQQLLDVQRQVALKSEEATA 975 >gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sapiens] Length = 1297 Score = 39.3 bits (90), Expect = 0.011 Identities = 53/203 (26%), Positives = 87/203 (42%), Gaps = 17/203 (8%) Query: 300 MPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQ 359 +PGE + FLR ++ +ER +E +R + Q +N + RQ L E + I Sbjct: 344 LPGESTLRRDFLRLQLANKER-----SEALRRQQLEQQQREN-EEHKRQLLAERQKRI-- 395 Query: 360 TLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPP--QAERVLLALRRYL 417 EEQ E++R +E R L Q R + ++ + +AE +RR L Sbjct: 396 --EEQ--KEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQL 451 Query: 418 RAEQKEQRHTLRHYQHVAAVDPE-KAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQE 476 EQ++ + H A+ E K +Q+ Q + ++ ++ Q L H QE Sbjct: 452 EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQ--RQAERLQRQLKQERDYLVSLQHQRQE 509 Query: 477 LRPQIQELLHSEHLGPSELEAPA 499 RP ++ L+ G S E PA Sbjct: 510 QRPVEKKPLYHYKEGMSPSEKPA 532 >gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sapiens] Length = 1305 Score = 39.3 bits (90), Expect = 0.011 Identities = 53/203 (26%), Positives = 87/203 (42%), Gaps = 17/203 (8%) Query: 300 MPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQ 359 +PGE + FLR ++ +ER +E +R + Q +N + RQ L E + I Sbjct: 344 LPGESTLRRDFLRLQLANKER-----SEALRRQQLEQQQREN-EEHKRQLLAERQKRI-- 395 Query: 360 TLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPP--QAERVLLALRRYL 417 EEQ E++R +E R L Q R + ++ + +AE +RR L Sbjct: 396 --EEQ--KEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQL 451 Query: 418 RAEQKEQRHTLRHYQHVAAVDPE-KAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQE 476 EQ++ + H A+ E K +Q+ Q + ++ ++ Q L H QE Sbjct: 452 EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQ--RQAERLQRQLKQERDYLVSLQHQRQE 509 Query: 477 LRPQIQELLHSEHLGPSELEAPA 499 RP ++ L+ G S E PA Sbjct: 510 QRPVEKKPLYHYKEGMSPSEKPA 532 >gi|4506803 stem cell growth factor precursor [Homo sapiens] Length = 323 Score = 39.3 bits (90), Expect = 0.011 Identities = 59/211 (27%), Positives = 81/211 (38%), Gaps = 48/211 (22%) Query: 222 AVGDPSTRSWP-PGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAV 280 A+G P+ R P VEG ED E EE + EEEEE P PSS Sbjct: 54 ALGLPAGRGDENPAGTVEGKEDWEMEEDQGE------------EEEEEATPTPSSGP--- 98 Query: 281 VGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSK 340 +P+P P D V G + L ++ + R+ ++ + +R+ A ++ Sbjct: 99 ----SPSPTPEDIVTYILGRLAGLDAGLHQLHVRLHALDTRVVELTQGLRQLRNAAGDTR 154 Query: 341 N----LPKADRQALNEHFQSILQTLEEQVSGER--------QRLVETHATRVIALINDQR 388 + L +A +A EH + LE + G R R E A Q Sbjct: 155 DAVQALQEAQGRAEREHGR-----LEGCLKGLRLGHKCFLLSRDFEAQAAA-------QA 202 Query: 389 RAALEGFLAALQADPPQAERVLLALRRYLRA 419 R G A AD Q E AL RYLRA Sbjct: 203 RCTARGGSLAQPADRQQME----ALTRYLRA 229 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.316 0.134 0.399 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 31,624,565 Number of Sequences: 37866 Number of extensions: 1852910 Number of successful extensions: 11574 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 65 Number of HSP's successfully gapped in prelim test: 326 Number of HSP's that attempted gapping in prelim test: 10472 Number of HSP's gapped (non-prelim): 1201 length of query: 651 length of database: 18,247,518 effective HSP length: 109 effective length of query: 542 effective length of database: 14,120,124 effective search space: 7653107208 effective search space used: 7653107208 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.