Search of human proteins with 67782313

Search of human proteins with 67782313

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo
sapiens]
         (652 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo sap...  1347   0.0  
gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo sap...  1307   0.0  
gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo sap...  1290   0.0  
gi|92859670 solute carrier family 6 (neurotransmitter transporte...   632   0.0  
gi|134304856 solute carrier family 6, member 7 [Homo sapiens]         623   e-178
gi|6005715 solute carrier family 6 (amino acid transporter), mem...   525   e-149
gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo sapi...   520   e-147
gi|188528618 solute carrier family 6 (neurotransmitter transport...   519   e-147
gi|7657587 solute carrier family 6 (neurotransmitter transporter...   518   e-147
gi|21361581 solute carrier family 6 (neurotransmitter transporte...   514   e-145
gi|171184408 solute carrier family 6 (neurotransmitter transport...   505   e-143
gi|171184406 solute carrier family 6 (neurotransmitter transport...   505   e-143
gi|171184404 solute carrier family 6 (neurotransmitter transport...   505   e-143
gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo sa...   502   e-142
gi|4507043 solute carrier family 6 member 4 [Homo sapiens]            488   e-138
gi|4557046 solute carrier family 6 member 2 [Homo sapiens]            481   e-136
gi|4507041 solute carrier family 6 (neurotransmitter transporter...   478   e-134
gi|197276623 solute carrier family 6 (neurotransmitter transport...   471   e-133
gi|54607094 solute carrier family 6 (neurotransmitter transporte...   471   e-133
gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo sa...   423   e-118
gi|51468073 solute carrier family 6, member 19 [Homo sapiens]         393   e-109
gi|194018524 solute carrier family 6, member 18 [Homo sapiens]        365   e-101
gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo s...   364   e-100
gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo s...   302   6e-82
gi|58219014 solute carrier family 6, member 17 [Homo sapiens]         299   5e-81
gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo s...   279   7e-75
gi|55749589 solute carrier family 6, member 16 [Homo sapiens]         223   3e-58
gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo ...   210   4e-54
gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo s...   169   7e-42
gi|197276625 solute carrier family 6 (neurotransmitter transport...   162   9e-40

>gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo
           sapiens]
          Length = 652

 Score = 1347 bits (3487), Expect = 0.0
 Identities = 652/652 (100%), Positives = 652/652 (100%)

Query: 1   MSGGDTRAAIARPRMAAAHGPVAPSSPEQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSV 60
           MSGGDTRAAIARPRMAAAHGPVAPSSPEQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSV
Sbjct: 1   MSGGDTRAAIARPRMAAAHGPVAPSSPEQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSV 60

Query: 61  GYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRI 120
           GYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRI
Sbjct: 61  GYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRI 120

Query: 121 SPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLD 180
           SPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLD
Sbjct: 121 SPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLD 180

Query: 181 ASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCL 240
           ASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCL
Sbjct: 181 ASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCL 240

Query: 241 GVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDK 300
           GVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDK
Sbjct: 241 GVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDK 300

Query: 301 ILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVI 360
           ILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVI
Sbjct: 301 ILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVI 360

Query: 361 FSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQF 420
           FSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQF
Sbjct: 361 FSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQF 420

Query: 421 CLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASF 480
           CLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASF
Sbjct: 421 CLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASF 480

Query: 481 SLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQ 540
           SLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQ
Sbjct: 481 SLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQ 540

Query: 541 YQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDW 600
           YQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDW
Sbjct: 541 YQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDW 600

Query: 601 GPALLEHRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI 652
           GPALLEHRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
Sbjct: 601 GPALLEHRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI 652


>gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo
           sapiens]
          Length = 706

 Score = 1307 bits (3383), Expect = 0.0
 Identities = 646/706 (91%), Positives = 649/706 (91%), Gaps = 54/706 (7%)

Query: 1   MSGGDTRAAIARPRMAAAHG----------------------PVAPSSPE---------- 28
           MSGGDTRAAIARPRMAAAHG                      P + ++P           
Sbjct: 1   MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKV 60

Query: 29  ----------------------QNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGL 66
                                 QNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGL
Sbjct: 61  WHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGL 120

Query: 67  GNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKG 126
           GNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKG
Sbjct: 121 GNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKG 180

Query: 127 VGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTN 186
           VGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTN
Sbjct: 181 VGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTN 240

Query: 187 GSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLV 246
           GSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLV
Sbjct: 241 GSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLV 300

Query: 247 VFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKV 306
           VFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKV
Sbjct: 301 VFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKV 360

Query: 307 WGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGF 366
           WGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGF
Sbjct: 361 WGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGF 420

Query: 367 MANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETL 426
           MANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETL
Sbjct: 421 MANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETL 480

Query: 427 VTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVIS 486
           VTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVIS
Sbjct: 481 VTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVIS 540

Query: 487 CIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITY 546
           CIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITY
Sbjct: 541 CIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITY 600

Query: 547 NHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLE 606
           NHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLE
Sbjct: 601 NHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLE 660

Query: 607 HRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI 652
           HRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
Sbjct: 661 HRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI 706


>gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo
           sapiens]
          Length = 633

 Score = 1290 bits (3339), Expect = 0.0
 Identities = 623/623 (100%), Positives = 623/623 (100%)

Query: 30  NGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYF 89
           NGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYF
Sbjct: 11  NGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYF 70

Query: 90  IMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIA 149
           IMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIA
Sbjct: 71  IMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIA 130

Query: 150 FYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTS 209
           FYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTS
Sbjct: 131 FYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTS 190

Query: 210 PSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFP 269
           PSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFP
Sbjct: 191 PSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFP 250

Query: 270 YVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMA 329
           YVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMA
Sbjct: 251 YVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMA 310

Query: 330 SYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVA 389
           SYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVA
Sbjct: 311 SYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVA 370

Query: 390 YPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLG 449
           YPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLG
Sbjct: 371 YPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLG 430

Query: 450 VAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMM 509
           VAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMM
Sbjct: 431 VAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMM 490

Query: 510 LGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLC 569
           LGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLC
Sbjct: 491 LGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLC 550

Query: 570 IPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTIAPSPEDGFEVQPL 629
           IPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTIAPSPEDGFEVQPL
Sbjct: 551 IPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTIAPSPEDGFEVQPL 610

Query: 630 HPDKAQIPIVGSNGSSRLQDSRI 652
           HPDKAQIPIVGSNGSSRLQDSRI
Sbjct: 611 HPDKAQIPIVGSNGSSRLQDSRI 633


>gi|92859670 solute carrier family 6 (neurotransmitter transporter,
           glycine), member 5 [Homo sapiens]
          Length = 797

 Score =  632 bits (1630), Expect = 0.0
 Identities = 299/609 (49%), Positives = 420/609 (68%), Gaps = 25/609 (4%)

Query: 31  GAVPSEATKRDQ----NLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMF 86
           G+V + AT+ D+    N  RGNW ++++F+L+ VGYAVGLGNVWRFPYL ++NGGGAF+ 
Sbjct: 172 GSVATVATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLI 231

Query: 87  PYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVI 146
           PY +ML   G+P+FF+E+S GQFASQG + VW+  P  +G G  M+++S  I IYYNV+I
Sbjct: 232 PYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVII 291

Query: 147 CIAFYYFFSSMTHVLPWAYCNNPWNTHDCAG----VLDASNLTNGSR------------- 189
           C   +Y F+S   VLPW  CNNPWNT +C      +LD+  +++  +             
Sbjct: 292 CYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAY 351

Query: 190 PAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFL 249
           P     N +   N +    S SEEY++ +VLK+S  I   GE+R PL  CL ++W++V+ 
Sbjct: 352 PNVTMVNFTSQANKTF--VSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYA 409

Query: 250 CLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGD 309
            L +G+K+SGKVVYFTATFPYVVL IL +RGVTL GA  GI Y++TP+W+K+ +A VW D
Sbjct: 410 SLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKD 469

Query: 310 AASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMAN 369
           AA+QIF+SL  AWGGLIT++SYNKFHNNCYRD++I++ TN ATS++AGFVIFS++GFMAN
Sbjct: 470 AATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMAN 529

Query: 370 HLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTA 429
              V++  VAD GPG+AFV YPEALT LP+SP W+++FF ML+ LGL T F  +ET+VT+
Sbjct: 530 ERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTS 589

Query: 430 IVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIM 489
           I DE   +++   K   TLG  +  F++G P+ +Q GIY   L+D YAAS++LV+I+   
Sbjct: 590 ISDEF-PKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFE 648

Query: 490 CVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHY 549
            V I Y+YG + + +DI+MM+GF P +F+++CW FV+P I+ FIL F+  Q++P+TY  Y
Sbjct: 649 LVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSY 708

Query: 550 QYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLEHRT 609
           +YP W++ +G+LM   SV+ IP+  + ++    G   ++RLK    P  DWGP L +HR 
Sbjct: 709 RYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPG-RFIERLKLVCSPQPDWGPFLAQHRG 767

Query: 610 GRYAPTIAP 618
            RY   I P
Sbjct: 768 ERYKNMIDP 776


>gi|134304856 solute carrier family 6, member 7 [Homo sapiens]
          Length = 636

 Score =  623 bits (1606), Expect = e-178
 Identities = 308/605 (50%), Positives = 421/605 (69%), Gaps = 24/605 (3%)

Query: 21  PVAPS---SPEQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCY 77
           PV P    +P   G V  +    D    RGNW  +++F+L+ +GY VGLGNVWRFPY  Y
Sbjct: 12  PVTPDLLMTPSDQGDVDLDV---DFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAY 68

Query: 78  RNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTY 137
            NGGGAF+ PYF+ML  CGIPLFF+ELS GQF+S G L VW+ISP+FKG G  M+++   
Sbjct: 69  TNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGL 128

Query: 138 IGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNL 197
           + IYYN++I    +Y F+S+T  LPW +C N WNT  C   L+     +G+   ALP NL
Sbjct: 129 VAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELC---LEHRVSKDGN--GALPLNL 183

Query: 198 SHLLNHSLQRTSPSEEYWRLYVLKL--SDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGV 255
           +  +       SPSEEYW  YVL +  S  IG+ GE+R  L  CL ++W++VFLC+++GV
Sbjct: 184 TCTV-------SPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGV 236

Query: 256 KSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIF 315
           KSSGKVVYFTATFPY++L +L VRGVTL GA+ GI +YLTPQ+  +L +KVW +AA QIF
Sbjct: 237 KSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIF 296

Query: 316 YSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDV 375
           YSLG  +GGL+T ASYN FH N YRD+ I+++ N  TS+ AGF IFS+LG+M+  LGV V
Sbjct: 297 YSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPV 356

Query: 376 SRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVG 435
            +VA  GPGLAFV YP+A+T+LP+SP WS LFFFML+ LGL +QF  LET+VTA+ DE  
Sbjct: 357 DQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEF- 415

Query: 436 NEWILQKKTYVTLG-VAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIM 494
             + L+ K  V  G + VA +L+G+ LT+  G+YWL+L+D+Y+ASF L+V+    C+A+ 
Sbjct: 416 -PYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVT 474

Query: 495 YIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGW 554
            +YG + + +DI MMLGF P L+F+ CW F+SPA +  ++V+++++YQP  Y  Y++P W
Sbjct: 475 RVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPW 534

Query: 555 AVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAP 614
           A  +G LM L S L IP   +  + R +G +L +RL+ A++P+ DWGP+L E+RTG Y  
Sbjct: 535 AELLGILMGLLSCLMIPAGMLVAVLREEG-SLWERLQQASRPAMDWGPSLEENRTGMYVA 593

Query: 615 TIAPS 619
           T+A S
Sbjct: 594 TLAGS 598


>gi|6005715 solute carrier family 6 (amino acid transporter), member
           14 [Homo sapiens]
          Length = 642

 Score =  525 bits (1353), Expect = e-149
 Identities = 266/607 (43%), Positives = 390/607 (64%), Gaps = 22/607 (3%)

Query: 39  KRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIP 98
           + D+N  RGNW  + +++L+ +GYAVGLGNVWRFPYL Y NGGGAF+ PY IML   G+P
Sbjct: 29  ENDENQDRGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLP 88

Query: 99  LFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMT 158
           LFF+E S GQFAS G + VWRI P+F+GVG  M+++S ++ IYYNV+I  + YY F+S  
Sbjct: 89  LFFLECSLGQFASLGPVSVWRILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASFQ 148

Query: 159 HVLPWAYCNNPWNTHDC--AGVLDASNLT--NGSRPAALPSNLS--HLLNHSLQRTS--- 209
             LPW  C++ W+  +C  + ++   N++  N      +  N S   + N +    S   
Sbjct: 149 SELPWKNCSS-WSDKNCSRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSEIY 207

Query: 210 -----PSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYF 264
                PSE+YW    L+ S  +   G +   L  CL ++WL+V   L +G+KSSGKVVYF
Sbjct: 208 QPGQLPSEQYWNKVALQRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYF 267

Query: 265 TATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQ--WDKILEAKVWGDAASQIFYSLGCAW 322
           TA FPYVVL IL VRG TLEGA  GI YY+  Q  + K+ EA+VW DAA+QIFYSL  AW
Sbjct: 268 TALFPYVVLLILLVRGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAW 327

Query: 323 GGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHG 382
           GGL+ ++SYNKF NNC+ D++++ +TNC TSV+AGF IFSILG MA+  G +VS+V   G
Sbjct: 328 GGLVALSSYNKFKNNCFSDAIVVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSG 387

Query: 383 PGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQK 442
             LAF+AYPEAL  LP  P WS+LFFFML+ LGL +QF  +ET+ T I D +  + + + 
Sbjct: 388 FDLAFIAYPEALAQLPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQD-LFPKVMKKM 446

Query: 443 KTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNY 502
           +  +TLG  +  FLLG+   +QAGIYW+ L+D++ A + +++ + +  V I++IYG   +
Sbjct: 447 RVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHFCAGWGILIAAILELVGIIWIYGGNRF 506

Query: 503 FQDIQMMLGFPPPLF---FQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIG 559
            +D +MM+G    +F   ++ CW  ++P ++  I +++++Q+    Y    YP W VA+G
Sbjct: 507 IEDTEMMIGAKRWIFWLWWRACWFVITPILLIAIFIWSLVQFHRPNYGAIPYPDWGVALG 566

Query: 560 FLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTIAPS 619
           + M +  ++ IP+ A+ ++ +  G+ + QRL +  +P+ +WGP L +HR  RY   + P 
Sbjct: 567 WCMIVFCIIWIPIMAIIKIIQAKGN-IFQRLISCCRPASNWGPYLEQHRGERYKDMVDPK 625

Query: 620 PEDGFEV 626
            E   E+
Sbjct: 626 KEADHEI 632


>gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo
           sapiens]
          Length = 635

 Score =  520 bits (1338), Expect = e-147
 Identities = 260/615 (42%), Positives = 380/615 (61%), Gaps = 27/615 (4%)

Query: 1   MSGGDTRAAIARP----RMAAAHGPVAPSSPEQNGAVPSEATKRDQNLKRGNWGNQIEFV 56
           +SG + +  +  P      A   GPV   +P    AVP   T          W  Q++F+
Sbjct: 13  VSGDEKKGPLIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRET----------WTRQMDFI 62

Query: 57  LTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLG 116
           ++ VG+AVGLGNVWRFPYLCY+NGGG F+ PY ++ +  GIP+FF+E+S GQF   G + 
Sbjct: 63  MSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSIN 122

Query: 117 VWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCA 176
           VW I P+FKG+GY  MV+  Y   YY +V+   FYY   S T  LPWA C + WNT DC 
Sbjct: 123 VWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCV 182

Query: 177 GVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPL 236
            +    +  N S      +NL+   +    R SP  E+W   VL+LS  +   G +   +
Sbjct: 183 EIFRHEDCANASL-----ANLT--CDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEV 235

Query: 237 LGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTP 296
             CL   W++V+ C+ +GVKS+GK+VYFTATFPYVVL +L VRGV L GA DGI+YYL P
Sbjct: 236 TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP 295

Query: 297 QWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYA 356
            W K+   +VW DA +QIF+S     G L  + SYN+F+NNCY+D++I+++ N  TS +A
Sbjct: 296 DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFA 355

Query: 357 GFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGL 416
           GFV+FSILGFMA   GV +S+VA+ GPGLAF+AYP A+TL+P++PLW+ LFFFML+LLGL
Sbjct: 356 GFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGL 415

Query: 417 GTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVA-GFLLGIPLTSQAGIYWLLLMDN 475
            +QF  +E  +T ++D +   +  + +  +++ +  A  F++ + + +  G+Y   L D 
Sbjct: 416 DSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDY 475

Query: 476 YAASFSLVVISCIM-CVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFIL 534
           Y+AS + ++      CV + ++YG   +  DI  M+G+ P  + + CW F +P +   I 
Sbjct: 476 YSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIF 535

Query: 535 VFTVIQYQPITYNH-YQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNA 593
           +F V+ Y+P+ YN+ Y YP W  A+G+  ALSS+LC+PL+ +  L R  G T+ +R ++ 
Sbjct: 536 IFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKG-TMAERWQHL 594

Query: 594 TKPSRDWGPALLEHR 608
           T+P   WG   LE+R
Sbjct: 595 TQPI--WGLHHLEYR 607


>gi|188528618 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 1 [Homo sapiens]
          Length = 599

 Score =  519 bits (1336), Expect = e-147
 Identities = 257/601 (42%), Positives = 382/601 (63%), Gaps = 27/601 (4%)

Query: 1   MSGGDTRAAIARPRMAAAHGPVAPSSPEQNGAVPSEATKRDQNLK-RGNWGNQIEFVLTS 59
           M+   ++ A  +     +  PVA   P+    +  +  K+  +L  R  W  + +F+++ 
Sbjct: 1   MATNGSKVADGQISTEVSEAPVANDKPK---TLVVKVQKKAADLPDRDTWKGRFDFLMSC 57

Query: 60  VGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWR 119
           VGYA+GLGNVWRFPYLC +NGGGAF+ PYF+ LIF G+PLF +E S GQ+ S G LGVW+
Sbjct: 58  VGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWK 117

Query: 120 ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVL 179
           ++PMFKGVG    V+S ++ IYY V+I  A YY ++S T  LPW  C+NPWNT  C    
Sbjct: 118 LAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNY 177

Query: 180 DASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGC 239
              N TN                     TS   E+W   + +++D +   G++R PL   
Sbjct: 178 SMVNTTN--------------------MTSAVVEFWERNMHQMTDGLDKPGQIRWPLAIT 217

Query: 240 LGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWD 299
           L ++W++V+ C+ +GV  +GKVVYF+AT+PY++L ILF RGVTL GA +GI++Y+TP + 
Sbjct: 218 LAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFR 277

Query: 300 KILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFV 359
           K+ +++VW DAA+QIF+S G   G LI + SYN FHNN YRDS+I+   N  TS++AGFV
Sbjct: 278 KLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFV 337

Query: 360 IFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQ 419
           IFSI+GFMA+     ++ VA  GPGLAF+AYPEA+T LPISPLW++LFF ML++LG+ +Q
Sbjct: 338 IFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQ 397

Query: 420 FCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAAS 479
           FC +E  +TA+VDE       +++ ++   V +  +L+G+   +Q GIY   L D Y+AS
Sbjct: 398 FCTVEGFITALVDEYPRLLRNRRELFIA-AVCIISYLIGLSNITQGGIYVFKLFDYYSAS 456

Query: 480 -FSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTV 538
             SL+ +    CV+I + YG   ++ +IQ M+G  P +++++CW F +P I+  + +F+ 
Sbjct: 457 GMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSA 516

Query: 539 IQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSR 598
           +Q  P+T  +Y +P W   +G+LMALSS++ IP Y  +      G +L QR++   +PS 
Sbjct: 517 VQMTPLTMGNYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKG-SLKQRIQVMVQPSE 575

Query: 599 D 599
           D
Sbjct: 576 D 576


>gi|7657587 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 11 [Homo sapiens]
          Length = 632

 Score =  518 bits (1333), Expect = e-147
 Identities = 254/577 (44%), Positives = 373/577 (64%), Gaps = 23/577 (3%)

Query: 31  GAVPSE--ATKRDQNL-KRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFP 87
           GA P+     KRD+ + +RG+W N++EFVL+  G  +GLGNVWRFPYLCY+NGGGAF+ P
Sbjct: 32  GAAPARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIP 91

Query: 88  YFIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVI 146
           Y +  I CGIP+FF+E + GQF S+G +  WR + P+F+G+GY   V+  ++ +YY +++
Sbjct: 92  YVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIIL 151

Query: 147 CIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQ 206
             A +Y  +  T  LPWA C + WNT +C      +            SN SH+   SLQ
Sbjct: 152 AWAIFYLSNCFTTELPWATCGHEWNTENCVEFQKLN-----------VSNYSHV---SLQ 197

Query: 207 R-TSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFT 265
             TSP  E+W   VL +SD I + G +R  L  CL  +W + + C+ +G KS+GKVVY T
Sbjct: 198 NATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVT 257

Query: 266 ATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGL 325
           ATFPY++L IL +RGVTL GA +GI +YL P   ++ + +VW DA +QIF+S     G L
Sbjct: 258 ATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCL 317

Query: 326 ITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGL 385
             + SYN ++NNCYRD +++   N  TS  AGF IFS+LGFMA   GV ++ VA+ GPGL
Sbjct: 318 TALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGL 377

Query: 386 AFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWIL-QKKT 444
           AF+AYP+A+T++P+SPLW+ LFF MLI LGL +QF  +E+LVTA+VD     +    ++ 
Sbjct: 378 AFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRE 437

Query: 445 YVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAAS-FSLVVISCIMCVAIMYIYGHRNYF 503
            + L ++V  + LG+ + ++ G+Y   L D+YAAS   L+ ++   C+ I ++YG   ++
Sbjct: 438 LLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFY 497

Query: 504 QDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNH-YQYPGWAVAIGFLM 562
            +I+ M+G+ PP   + CW  ++P I   I +F +I+Y+P+ YN+ Y YP W   IG+LM
Sbjct: 498 DNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGWLM 557

Query: 563 ALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRD 599
           ALSS+LCIPL+    + +T+G TL ++L+  T PS D
Sbjct: 558 ALSSMLCIPLWICITVWKTEG-TLPEKLQKLTTPSTD 593


>gi|21361581 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 13 [Homo sapiens]
          Length = 602

 Score =  514 bits (1323), Expect = e-145
 Identities = 250/570 (43%), Positives = 364/570 (63%), Gaps = 24/570 (4%)

Query: 36  EATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFC 95
           E  + D  L+RG+W N++EFVL+  G  +GLGNVWRFPYLCY+NGGGAF  PY + L  C
Sbjct: 22  EKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTC 81

Query: 96  GIPLFFMELSFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFF 154
           GIP+F +E + GQ+ SQG +  WR I P+F+G+GY   ++   + +YY +V+  A +Y F
Sbjct: 82  GIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLF 141

Query: 155 SSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEY 214
           SS T  LPW  C + WNT  C      +   NG+   A               TSP  E+
Sbjct: 142 SSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENA---------------TSPVIEF 186

Query: 215 WRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLT 274
           W   VLK+SD I + G +R  L  CL ++W++ + C+ +GVKS+GKVVYFTATFPY++L 
Sbjct: 187 WERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLV 246

Query: 275 ILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKF 334
           +L +RGVTL GA  GI +YL P   ++ + +VW DA +QIF+S     G L  + SYNK+
Sbjct: 247 VLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKY 306

Query: 335 HNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEAL 394
           HNNCYRD + +   N  TS  AGF IFSILGFM+   GV +S VA+ GPGLAF+AYP A+
Sbjct: 307 HNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAV 366

Query: 395 TLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKT---YVTLGVA 451
            +LP SPLW+  FFFM++LLGL +QF  +E+LVTA+VD   +  + +KK     + LGV+
Sbjct: 367 VMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPH--VFRKKNRREVLILGVS 424

Query: 452 VAGFLLGIPLTSQAGIYWLLLMDNYAAS-FSLVVISCIMCVAIMYIYGHRNYFQDIQMML 510
           V  FL+G+ + ++ G+Y   L D YAAS   L+ ++    + + ++YG + ++ +I+ M+
Sbjct: 425 VVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMI 484

Query: 511 GFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYN-HYQYPGWAVAIGFLMALSSVLC 569
           G+ P    + CW F++PA+     +F++I+Y P+TYN  Y YP W  A+G+L+ALSS++C
Sbjct: 485 GYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVC 544

Query: 570 IPLYAMFRLCRTDGDTLLQRLKNATKPSRD 599
           IP ++++RL    G    +R++    P+ D
Sbjct: 545 IPAWSLYRLGTLKG-PFRERIRQLMCPAED 573


>gi|171184408 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  505 bits (1300), Expect = e-143
 Identities = 251/573 (43%), Positives = 363/573 (63%), Gaps = 24/573 (4%)

Query: 33  VPSEATKRDQNLK-----RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFP 87
           VP E  K DQ  +     RG W N++EFVL+  G  +GLGNVWRFPYLCY+NGGGAF  P
Sbjct: 18  VPEEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIP 77

Query: 88  YFIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVI 146
           YFI    CGIP+FF+E++ GQ+ SQG +  WR I P+F+G+G   +V+ +Y+ +YY +++
Sbjct: 78  YFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIIL 137

Query: 147 CIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQ 206
             A +Y FSS T  LPW  CNN WNT  C   L+ S    G+       N          
Sbjct: 138 AWALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHS----GAGTVTPFENF--------- 184

Query: 207 RTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTA 266
            TSP  E+W   VL ++  I + G +R  L  CL ++W++ + C+ +GVKS+GKVVYFTA
Sbjct: 185 -TSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTA 243

Query: 267 TFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLI 326
           TFPY++L IL +RGVTL GA+ GI+YYL P   ++ + +VW DA +QIF+S     G L 
Sbjct: 244 TFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLT 303

Query: 327 TMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLA 386
            + SYNK+HNNCY+D + +   N ATS  AGFV+FSILGFM+   GV +S VA+ GPGLA
Sbjct: 304 ALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGPGLA 363

Query: 387 FVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQ-KKTY 445
           F+A+P+A+T++P+S LWS LFF MLI LGL +QF  +E LVTA +D    +     ++  
Sbjct: 364 FIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRREL 423

Query: 446 VTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAAS-FSLVVISCIMCVAIMYIYGHRNYFQ 504
           + L +AV  +L+G+ L ++ G+Y   L D YA+S   L+ +S    V I ++YG   ++ 
Sbjct: 424 LILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADRFYD 483

Query: 505 DIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNH-YQYPGWAVAIGFLMA 563
           +I+ M+G+ P    +I W F++P +     +F++ +Y P+ YN+ Y YP W  +IG+ +A
Sbjct: 484 NIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLA 543

Query: 564 LSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKP 596
           LSS++C+PL+ +  L +T G    +RL+    P
Sbjct: 544 LSSMVCVPLFVVITLLKTRG-PFRKRLRQLITP 575


>gi|171184406 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  505 bits (1300), Expect = e-143
 Identities = 251/573 (43%), Positives = 363/573 (63%), Gaps = 24/573 (4%)

Query: 33  VPSEATKRDQNLK-----RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFP 87
           VP E  K DQ  +     RG W N++EFVL+  G  +GLGNVWRFPYLCY+NGGGAF  P
Sbjct: 18  VPEEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIP 77

Query: 88  YFIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVI 146
           YFI    CGIP+FF+E++ GQ+ SQG +  WR I P+F+G+G   +V+ +Y+ +YY +++
Sbjct: 78  YFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIIL 137

Query: 147 CIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQ 206
             A +Y FSS T  LPW  CNN WNT  C   L+ S    G+       N          
Sbjct: 138 AWALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHS----GAGTVTPFENF--------- 184

Query: 207 RTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTA 266
            TSP  E+W   VL ++  I + G +R  L  CL ++W++ + C+ +GVKS+GKVVYFTA
Sbjct: 185 -TSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTA 243

Query: 267 TFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLI 326
           TFPY++L IL +RGVTL GA+ GI+YYL P   ++ + +VW DA +QIF+S     G L 
Sbjct: 244 TFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLT 303

Query: 327 TMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLA 386
            + SYNK+HNNCY+D + +   N ATS  AGFV+FSILGFM+   GV +S VA+ GPGLA
Sbjct: 304 ALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGPGLA 363

Query: 387 FVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQ-KKTY 445
           F+A+P+A+T++P+S LWS LFF MLI LGL +QF  +E LVTA +D    +     ++  
Sbjct: 364 FIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRREL 423

Query: 446 VTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAAS-FSLVVISCIMCVAIMYIYGHRNYFQ 504
           + L +AV  +L+G+ L ++ G+Y   L D YA+S   L+ +S    V I ++YG   ++ 
Sbjct: 424 LILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADRFYD 483

Query: 505 DIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNH-YQYPGWAVAIGFLMA 563
           +I+ M+G+ P    +I W F++P +     +F++ +Y P+ YN+ Y YP W  +IG+ +A
Sbjct: 484 NIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLA 543

Query: 564 LSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKP 596
           LSS++C+PL+ +  L +T G    +RL+    P
Sbjct: 544 LSSMVCVPLFVVITLLKTRG-PFRKRLRQLITP 575


>gi|171184404 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  505 bits (1300), Expect = e-143
 Identities = 251/573 (43%), Positives = 363/573 (63%), Gaps = 24/573 (4%)

Query: 33  VPSEATKRDQNLK-----RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFP 87
           VP E  K DQ  +     RG W N++EFVL+  G  +GLGNVWRFPYLCY+NGGGAF  P
Sbjct: 18  VPEEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIP 77

Query: 88  YFIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVI 146
           YFI    CGIP+FF+E++ GQ+ SQG +  WR I P+F+G+G   +V+ +Y+ +YY +++
Sbjct: 78  YFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIIL 137

Query: 147 CIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQ 206
             A +Y FSS T  LPW  CNN WNT  C   L+ S    G+       N          
Sbjct: 138 AWALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHS----GAGTVTPFENF--------- 184

Query: 207 RTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTA 266
            TSP  E+W   VL ++  I + G +R  L  CL ++W++ + C+ +GVKS+GKVVYFTA
Sbjct: 185 -TSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTA 243

Query: 267 TFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLI 326
           TFPY++L IL +RGVTL GA+ GI+YYL P   ++ + +VW DA +QIF+S     G L 
Sbjct: 244 TFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLT 303

Query: 327 TMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLA 386
            + SYNK+HNNCY+D + +   N ATS  AGFV+FSILGFM+   GV +S VA+ GPGLA
Sbjct: 304 ALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGPGLA 363

Query: 387 FVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQ-KKTY 445
           F+A+P+A+T++P+S LWS LFF MLI LGL +QF  +E LVTA +D    +     ++  
Sbjct: 364 FIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRREL 423

Query: 446 VTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAAS-FSLVVISCIMCVAIMYIYGHRNYFQ 504
           + L +AV  +L+G+ L ++ G+Y   L D YA+S   L+ +S    V I ++YG   ++ 
Sbjct: 424 LILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADRFYD 483

Query: 505 DIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNH-YQYPGWAVAIGFLMA 563
           +I+ M+G+ P    +I W F++P +     +F++ +Y P+ YN+ Y YP W  +IG+ +A
Sbjct: 484 NIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLA 543

Query: 564 LSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKP 596
           LSS++C+PL+ +  L +T G    +RL+    P
Sbjct: 544 LSSMVCVPLFVVITLLKTRG-PFRKRLRQLITP 575


>gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo
           sapiens]
          Length = 625

 Score =  502 bits (1292), Expect = e-142
 Identities = 257/615 (41%), Positives = 371/615 (60%), Gaps = 37/615 (6%)

Query: 1   MSGGDTRAAIARP----RMAAAHGPVAPSSPEQNGAVPSEATKRDQNLKRGNWGNQIEFV 56
           +SG + +  +  P      A   GPV   +P    AVP   T          W  Q++F+
Sbjct: 13  VSGDEKKGPLIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRET----------WTRQMDFI 62

Query: 57  LTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLG 116
           ++ VG+AVGLGNVWRFPYLCY+NGGG F+ PY ++ +  GIP+FF+E+S GQF   G + 
Sbjct: 63  MSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSIN 122

Query: 117 VWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCA 176
           VW I P+FKG+GY  MV+  Y   YY +V+   FYY   S T  LPWA C + WNT DC 
Sbjct: 123 VWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCV 182

Query: 177 GVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPL 236
            +    +  N S      +NL+   +    R SP  E+W   VL+LS  +   G +   +
Sbjct: 183 EIFRHEDCANASL-----ANLT--CDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEV 235

Query: 237 LGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTP 296
             CL   W++V+ C+ +GVKS+GK+VYFTATFPYVVL +L VRGV L GA DGI+YYL P
Sbjct: 236 TLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKP 295

Query: 297 QWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYA 356
            W K+   +VW DA +QIF+S     G L  + SYN+F+NNCY            TS +A
Sbjct: 296 DWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYN----------GTSFFA 345

Query: 357 GFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGL 416
           GFV+FSILGFMA   GV +S+VA+ GPGLAF+AYP A+TL+P++PLW+ LFFFML+LLGL
Sbjct: 346 GFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGL 405

Query: 417 GTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVA-GFLLGIPLTSQAGIYWLLLMDN 475
            +QF  +E  +T ++D +   +  + +  +++ +  A  F++ + + +  G+Y   L D 
Sbjct: 406 DSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDY 465

Query: 476 YAASFSLVVISCIM-CVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFIL 534
           Y+AS + ++      CV + ++YG   +  DI  M+G+ P  + + CW F +P +   I 
Sbjct: 466 YSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIF 525

Query: 535 VFTVIQYQPITYNH-YQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNA 593
           +F V+ Y+P+ YN+ Y YP W  A+G+  ALSS+LC+PL+ +  L R  G T+ +R ++ 
Sbjct: 526 IFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKG-TMAERWQHL 584

Query: 594 TKPSRDWGPALLEHR 608
           T+P   WG   LE+R
Sbjct: 585 TQPI--WGLHHLEYR 597


>gi|4507043 solute carrier family 6 member 4 [Homo sapiens]
          Length = 630

 Score =  488 bits (1255), Expect = e-138
 Identities = 238/583 (40%), Positives = 362/583 (62%), Gaps = 26/583 (4%)

Query: 21  PVAPSSPEQNGAVPSEATKRDQNLKRGN---WGNQIEFVLTSVGYAVGLGNVWRFPYLCY 77
           P   +  +   ++P+  T     L +G    WG +++F+L+ +GYAV LGNVWRFPY+CY
Sbjct: 51  PSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICY 110

Query: 78  RNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPMFKGVGYGMMVVST 136
           +NGGGAF+ PY IM IF GIPLF+MEL+ GQ+   GC+ +WR I P+FKG+GY + +++ 
Sbjct: 111 QNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAF 170

Query: 137 YIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSN 196
           YI  YYN ++  A YY  SS T  LPW  C N WNT +C       N+T           
Sbjct: 171 YIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNIT----------- 219

Query: 197 LSHLLNHSLQRTSPSEEYWRLYVLKL--SDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRG 254
                  +L  TSP+EE++  +VL++  S  + + G +   L  C+ + + V++  + +G
Sbjct: 220 ------WTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKG 273

Query: 255 VKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQI 314
           VK+SGKVV+ TATFPY++L++L VRG TL GA+ G+++YL P W K+LE  VW DAA+QI
Sbjct: 274 VKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQI 333

Query: 315 FYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVD 374
           F+SLG  +G L+  ASYNKF+NNCY+D+++ S+ NC TS  +GFVIF++LG+MA     D
Sbjct: 334 FFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNED 393

Query: 375 VSRVA-DHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDE 433
           VS VA D GP L F+ Y EA+  +P S  ++++FF MLI LGL + F  LE ++TA++DE
Sbjct: 394 VSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDE 453

Query: 434 VGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAI 493
             + W  +++ +V L V +  F   +   +  G Y + L++ YA   +++ ++ I  VA+
Sbjct: 454 FPHVWAKRRERFV-LAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAV 512

Query: 494 MYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPG 553
            + YG   + +D++ MLGF P  F++ICW  +SP  + FI+   ++    +    Y YP 
Sbjct: 513 SWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPY 572

Query: 554 WAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKP 596
           W++ +G+ +  SS +CIP Y  +RL  T G T  +R+  +  P
Sbjct: 573 WSIILGYCIGTSSFICIPTYIAYRLIITPG-TFKERIIKSITP 614


>gi|4557046 solute carrier family 6 member 2 [Homo sapiens]
          Length = 617

 Score =  481 bits (1238), Expect = e-136
 Identities = 244/574 (42%), Positives = 362/574 (63%), Gaps = 16/574 (2%)

Query: 28  EQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFP 87
           E+NG     A +      R  WG +I+F+L+ VG+AV L NVWRFPYLCY+NGGGAF+ P
Sbjct: 38  ERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIP 97

Query: 88  YFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVIC 147
           Y + LI  G+PLF+MEL+ GQ+  +G   VW+I P FKGVGY +++++ Y+G YYNV+I 
Sbjct: 98  YTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIA 157

Query: 148 IAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQR 207
            + YY FSS T  LPW  C + WN+ +C        L NGS        L +   +S  +
Sbjct: 158 WSLYYLFSSFTLNLPWTDCGHTWNSPNCTD----PKLLNGSV-------LGNHTKYSKYK 206

Query: 208 TSPSEEYWRLYVLKLSDDIG--NFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFT 265
            +P+ E++   VL L +  G  + G  +  LL CL V  +V++  L +GVK+SGKVV+ T
Sbjct: 207 FTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWIT 266

Query: 266 ATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGL 325
           AT PY VL +L V GVTL GA +GI  YL   + ++ EA VW DAA+QIF+SLG  +G L
Sbjct: 267 ATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVL 326

Query: 326 ITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGL 385
           I  ASYNKF NNCYRD+++ S  NC TS  +GF IFSILG+MA+   V++  VA  G GL
Sbjct: 327 IAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGL 386

Query: 386 AFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTY 445
            F+ YPEA++ L  S  W+++FF ML+ LGL +    +E ++T + D+   + + + +  
Sbjct: 387 VFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDF--QVLKRHRKL 444

Query: 446 VTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQD 505
            T GV  + FLL +   ++ GIY L L+D +AA  S++    +  + + + YG   +  D
Sbjct: 445 FTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSND 504

Query: 506 IQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALS 565
           IQ M+GF P L++++CW+FVSPA + F++V ++I ++P+TY+ Y +P WA  +G+ +ALS
Sbjct: 505 IQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALS 564

Query: 566 SVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRD 599
           S++ +P+Y +++   T G +L +RL     P  +
Sbjct: 565 SMVLVPIYVIYKFLSTQG-SLWERLAYGITPENE 597


>gi|4507041 solute carrier family 6 (neurotransmitter transporter,
           dopamine), member 3 [Homo sapiens]
          Length = 620

 Score =  478 bits (1229), Expect = e-134
 Identities = 239/582 (41%), Positives = 365/582 (62%), Gaps = 27/582 (4%)

Query: 28  EQNGAVPSEATKRDQNLK------RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGG 81
           EQNG   + +T  +          R  WG +I+F+L+ +G+AV L NVWRFPYLCY+NGG
Sbjct: 36  EQNGVQLTSSTLTNPRQSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGG 95

Query: 82  GAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIY 141
           GAF+ PY + ++  G+PLF+MEL+ GQF  +G  GVW+I P+ KGVG+ ++++S Y+G +
Sbjct: 96  GAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILKGVGFTVILISLYVGFF 155

Query: 142 YNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVL--DASNLTNGSRPAALPSNLSH 199
           YNV+I  A +Y FSS T  LPW +CNN WN+ +C+     D+S  ++G            
Sbjct: 156 YNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSG------------ 203

Query: 200 LLNHSLQRTSPSEEYWRLYVLKL--SDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKS 257
            LN +   T+P+ EY+   VL L  S  I + G  R  L  CL +  ++++  L +GVK+
Sbjct: 204 -LNDTFG-TTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKT 261

Query: 258 SGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYS 317
           SGKVV+ TAT PYVVLT L +RGVTL GA DGI  YL+  + ++ EA VW DAA+Q+ +S
Sbjct: 262 SGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFS 321

Query: 318 LGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSR 377
           LG  +G LI  +SYNKF NNCYRD+++ +  N  TS  +GFV+FS LG+MA    V +  
Sbjct: 322 LGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGD 381

Query: 378 VADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNE 437
           VA  GPGL F+ YPEA+  LP+S  W+++FF ML+ LG+ +    +E+++T ++DE   +
Sbjct: 382 VAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEF--Q 439

Query: 438 WILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIY 497
            + + +   TL + +A FLL +   +  GIY   L+D++AA  S++    I  + + + Y
Sbjct: 440 LLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFY 499

Query: 498 GHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVA 557
           G   +  DIQ M G  P L++++CW+ VSP  + F++V +++ ++P  Y  Y +P WA A
Sbjct: 500 GVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANA 559

Query: 558 IGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRD 599
           +G+++A SS+  +P+YA ++ C   G +  ++L  A  P +D
Sbjct: 560 LGWVIATSSMAMVPIYAAYKFCSLPG-SFREKLAYAIAPEKD 600


>gi|197276623 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  471 bits (1213), Expect = e-133
 Identities = 239/576 (41%), Positives = 356/576 (61%), Gaps = 20/576 (3%)

Query: 19  HGPVAPSSPEQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYR 78
           H  +   SP ++     E     +  +R  W ++I+FVL+  G  VGLGNVWRFPYLCY+
Sbjct: 14  HKDILKPSPGKSPGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYK 73

Query: 79  NGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVW-RISPMFKGVGYGMMVVSTY 137
           NGGGAF+ PYFI L   G+P+FF+E+  GQ+ S+G +  W +I P+F G+GY  +V+ + 
Sbjct: 74  NGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSL 133

Query: 138 IGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNL 197
           + +YY V++  A YY F S    LPWA+CN+ WNT  C   ++ +   N S    + S  
Sbjct: 134 LNVYYIVILAWATYYLFQSFQKELPWAHCNHSWNTPHC---MEDTMRKNKSVWITISST- 189

Query: 198 SHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKS 257
                     TSP  E+W   VL LS  I + G ++  L  CL + WLV F C+ +GV+S
Sbjct: 190 --------NFTSPVIEFWERNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRS 241

Query: 258 SGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYS 317
           +GKVVYFTATFP+ +L +L VRG+TL GA  GI +YL P   ++ + +VW DA +QIF+S
Sbjct: 242 TGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFS 301

Query: 318 LGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSR 377
                G + ++ SYNK+  N YRD +++   N  TS  +GF IFSILGFMA   GVD++ 
Sbjct: 302 YAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIAD 361

Query: 378 VADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNE 437
           VA+ GPGLAF+AYP+A+T++P+   WS+LFF ML+LLGL +QF  +E  +T++VD   + 
Sbjct: 362 VAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPS- 420

Query: 438 WILQK---KTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAAS-FSLVVISCIMCVAI 493
             L+K   +      V    +LLG+ + ++ G+Y   L D YAAS   L+ ++   C  I
Sbjct: 421 -FLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVI 479

Query: 494 MYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNH-YQYP 552
            +IYG  N +  I+ M+G+ P  + +  W  ++P +     +F++++Y P+TYN  Y YP
Sbjct: 480 AWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYVYP 539

Query: 553 GWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQ 588
            WA+ +G+ +ALSS+LC+PL  + RLC+T+G  L++
Sbjct: 540 NWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVR 575


>gi|54607094 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  471 bits (1213), Expect = e-133
 Identities = 239/576 (41%), Positives = 356/576 (61%), Gaps = 20/576 (3%)

Query: 19  HGPVAPSSPEQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYR 78
           H  +   SP ++     E     +  +R  W ++I+FVL+  G  VGLGNVWRFPYLCY+
Sbjct: 14  HKDILKPSPGKSPGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYK 73

Query: 79  NGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVW-RISPMFKGVGYGMMVVSTY 137
           NGGGAF+ PYFI L   G+P+FF+E+  GQ+ S+G +  W +I P+F G+GY  +V+ + 
Sbjct: 74  NGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSL 133

Query: 138 IGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNL 197
           + +YY V++  A YY F S    LPWA+CN+ WNT  C   ++ +   N S    + S  
Sbjct: 134 LNVYYIVILAWATYYLFQSFQKELPWAHCNHSWNTPHC---MEDTMRKNKSVWITISST- 189

Query: 198 SHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKS 257
                     TSP  E+W   VL LS  I + G ++  L  CL + WLV F C+ +GV+S
Sbjct: 190 --------NFTSPVIEFWERNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRS 241

Query: 258 SGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYS 317
           +GKVVYFTATFP+ +L +L VRG+TL GA  GI +YL P   ++ + +VW DA +QIF+S
Sbjct: 242 TGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFS 301

Query: 318 LGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSR 377
                G + ++ SYNK+  N YRD +++   N  TS  +GF IFSILGFMA   GVD++ 
Sbjct: 302 YAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIAD 361

Query: 378 VADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNE 437
           VA+ GPGLAF+AYP+A+T++P+   WS+LFF ML+LLGL +QF  +E  +T++VD   + 
Sbjct: 362 VAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPS- 420

Query: 438 WILQK---KTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAAS-FSLVVISCIMCVAI 493
             L+K   +      V    +LLG+ + ++ G+Y   L D YAAS   L+ ++   C  I
Sbjct: 421 -FLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVI 479

Query: 494 MYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNH-YQYP 552
            +IYG  N +  I+ M+G+ P  + +  W  ++P +     +F++++Y P+TYN  Y YP
Sbjct: 480 AWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYVYP 539

Query: 553 GWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQ 588
            WA+ +G+ +ALSS+LC+PL  + RLC+T+G  L++
Sbjct: 540 NWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVR 575


>gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo
           sapiens]
          Length = 520

 Score =  423 bits (1087), Expect = e-118
 Identities = 211/499 (42%), Positives = 312/499 (62%), Gaps = 13/499 (2%)

Query: 113 GCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNT 172
           G + VW I P+FKG+GY  MV+  Y   YY +V+   FYY   S T  LPWA C + WNT
Sbjct: 4   GSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNT 63

Query: 173 HDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEV 232
            DC  +    +  N S      +NL+   +    R SP  E+W   VL+LS  +   G +
Sbjct: 64  PDCVEIFRHEDCANASL-----ANLT--CDQLADRRSPVIEFWENKVLRLSGGLEVPGAL 116

Query: 233 RLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMY 292
              +  CL   W++V+ C+ +GVKS+GK+VYFTATFPYVVL +L VRGV L GA DGI+Y
Sbjct: 117 NWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIY 176

Query: 293 YLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCAT 352
           YL P W K+   +VW DA +QIF+S     G L  + SYN+F+NNCY+D++I+++ N  T
Sbjct: 177 YLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGT 236

Query: 353 SVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLI 412
           S +AGFV+FSILGFMA   GV +S+VA+ GPGLAF+AYP A+TL+P++PLW+ LFFFML+
Sbjct: 237 SFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLL 296

Query: 413 LLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVA-GFLLGIPLTSQAGIYWLL 471
           LLGL +QF  +E  +T ++D +   +  + +  +++ +  A  F++ + + +  G+Y   
Sbjct: 297 LLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQ 356

Query: 472 LMDNYAASFSLVVISCIM-CVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAII 530
           L D Y+AS + ++      CV + ++YG   +  DI  M+G+ P  + + CW F +P + 
Sbjct: 357 LFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVC 416

Query: 531 FFILVFTVIQYQPITYNH-YQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQR 589
             I +F V+ Y+P+ YN+ Y YP W  A+G+  ALSS+LC+PL+ +  L R  G T+ +R
Sbjct: 417 MGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKG-TMAER 475

Query: 590 LKNATKPSRDWGPALLEHR 608
            ++ T+P   WG   LE+R
Sbjct: 476 WQHLTQPI--WGLHHLEYR 492


>gi|51468073 solute carrier family 6, member 19 [Homo sapiens]
          Length = 634

 Score =  393 bits (1009), Expect = e-109
 Identities = 223/637 (35%), Positives = 339/637 (53%), Gaps = 107/637 (16%)

Query: 26  SPEQNGAVPS----EATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGG 81
           +P  +  +PS    E  ++++   R  W N+ +++LT +G+ VGLGNVWRFPYLC  +GG
Sbjct: 8   NPGLDARIPSLAELETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGG 67

Query: 82  GAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGI 140
           GAFM P+ I+L+  GIPL ++E + GQ   +G LGVW  I P  KG+G   M+ S  +G+
Sbjct: 68  GAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGL 127

Query: 141 YYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHL 200
           YYN +I    +Y F+S    LPW+ C  P N +    V + +                  
Sbjct: 128 YYNTIISWIMWYLFNSFQEPLPWSDC--PLNENQTGYVDECA------------------ 167

Query: 201 LNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGK 260
                 R+SP + +W    L +S  I + G ++  +L CL  +W V+++C IRG++++GK
Sbjct: 168 ------RSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGK 221

Query: 261 VVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGC 320
            VY T+T PYVVLTI  +RG+TL+GA +GI++  TP   ++ +   W DA +Q+F+S   
Sbjct: 222 AVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSL 281

Query: 321 AWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILG----------FMANH 370
           A+GGLI+ +SYN  HNNC +DSVI+SI N  TSVY   V++S++G          F  N 
Sbjct: 282 AFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNI 341

Query: 371 L----GVDVSR--------------------------------------VADHGPGLAFV 388
           L    G D+                                         A  G GLAF+
Sbjct: 342 LTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFI 401

Query: 389 AYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVD--EVGNEWILQKKTYV 446
            + EA+T +P+SPLWS+LFF ML  LGL + F  +E +V  + D   +  +W    K  +
Sbjct: 402 VFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKW---PKEVL 458

Query: 447 TLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDI 506
           T  + +  FL+G   T  +G YWL L+D+YA S  L++I+     +++Y+YG   + +DI
Sbjct: 459 TGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDI 518

Query: 507 QMMLGFPPPLFFQICWRFVSP--AIIFFILVFTVIQYQPITYNHY-------------QY 551
           + M+G  P +F+Q+ WR VSP   +I F+  F V   Q +TY+ +              Y
Sbjct: 519 EFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISY 578

Query: 552 PGWAVAIGFLMALSSVLCIPLYAMFRL----CRTDGD 584
           P W   +  ++A    L IP YA+++L    C+  GD
Sbjct: 579 PNWVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQKPGD 615


>gi|194018524 solute carrier family 6, member 18 [Homo sapiens]
          Length = 628

 Score =  365 bits (936), Expect = e-101
 Identities = 210/602 (34%), Positives = 321/602 (53%), Gaps = 96/602 (15%)

Query: 45  KRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMEL 104
           +R  W N+ +++L+  G+AVGLGN+WRFPYLC   GGGAF+ PY I L+F GIP+F +EL
Sbjct: 17  ERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVEL 76

Query: 105 SFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPW 163
           + GQ   +G +GVW  ISP   GVG G + +S  I +YYN ++    +Y  +S  H LPW
Sbjct: 77  AIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPW 136

Query: 164 AYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLS 223
           + C    N     G ++                         Q +S    +W    L ++
Sbjct: 137 SSCPPDLNR---TGFVE-----------------------ECQGSSAVSYFWYRQTLNIT 170

Query: 224 DDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTL 283
            DI + G ++  LL CL  SW VV++C+IRG++++GKV+YFTA FPY+VLTI  +RG+TL
Sbjct: 171 ADINDSGSIQWWLLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTL 230

Query: 284 EGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSV 343
            GA  G++Y  TP    +   +VW DAA+QIF+SL  A+GG I  ASYN   N+C +D+V
Sbjct: 231 PGATKGLIYLFTPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAV 290

Query: 344 IISITNCATSVYAGFVIFSILGFMA----------NHLGV-------DVSRVADHGPGLA 386
           +I++ N  TS+YA   +FS+LGF A          N L +       + S   D  P + 
Sbjct: 291 VIALVNRMTSLYASIAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVL 350

Query: 387 F---VAYPEALTLLPI--------------------------------SPLWSLLFFFML 411
                 +P+ +  LP+                                +P+W++LFF ML
Sbjct: 351 MHLNATWPKRVAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGML 410

Query: 412 ILLGLGTQFCLLETLVTAIVD-EVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWL 470
             LGL T F  +E ++T ++D  V   W+   K  +T  V +  FL     T Q+G YWL
Sbjct: 411 FTLGLSTMFGTVEAVITPLLDVGVLPRWV--PKEALTGLVCLVCFLSATCFTLQSGNYWL 468

Query: 471 LLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAII 530
            + DN+AAS +L++++ +  V ++Y+YG + +  DI  M G  P  ++++ WR VSP ++
Sbjct: 469 EIFDNFAASPNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLL 528

Query: 531 -FFILVFTVIQYQPITYNHYQ-------------YPGWAVAIGFLMALSSVLCIPLYAMF 576
             F+    ++ ++P+ Y  +              YPGWA A   L++L  VL +P+ A+ 
Sbjct: 529 TIFVAYIILLFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALA 588

Query: 577 RL 578
           +L
Sbjct: 589 QL 590


>gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo
           sapiens]
          Length = 592

 Score =  364 bits (935), Expect = e-100
 Identities = 213/610 (34%), Positives = 317/610 (51%), Gaps = 102/610 (16%)

Query: 49  WGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQ 108
           W N ++FV   + YAVGLGNVWRFPYLC   GGG+F+ PY IMLI  G+PL ++EL+ GQ
Sbjct: 8   WANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQ 67

Query: 109 FASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCN 167
              QG +G WR ISP   GVG   +VVS ++ +YYNV+   AF+Y F S    LPW+ C 
Sbjct: 68  RMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVC- 126

Query: 168 NPWNTHDCAGVLDASNLTNGSRPAALPSNLSHL-LNHSLQRTSPSEEYWRLYVLKLSDDI 226
                                     P N +H   +   ++ S ++ +W    L +S  +
Sbjct: 127 --------------------------PLNGNHTGYDEECEKASSTQYFWYRKTLNISPSL 160

Query: 227 GNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGA 286
              G V+     CL ++WLVV+LC++RG +S+GKVVYFTA+ PY VL I  +RG+TL GA
Sbjct: 161 QENGGVQWEPALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGA 220

Query: 287 FDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIIS 346
            +G+MY  TP+ +++   K W +AA+QIF+SLG  +G LI  ASYN+  NNC + ++I+S
Sbjct: 221 TNGLMYMFTPKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVS 280

Query: 347 ITNCATSVYAGFVIFS---------------------------------------ILGFM 367
           + N  TS++A  V FS                                       + G++
Sbjct: 281 LINSFTSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYL 340

Query: 368 ANHLGVDVSRV---------------ADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLI 412
           A+      S +               A  G GLAF+ Y EA+  + +S LWS+L+FFML+
Sbjct: 341 ASAYPSKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLL 400

Query: 413 LLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLL 472
           +LG+G+       ++T + D       L K+    L V +    +G+  T +AG YW  +
Sbjct: 401 MLGIGSMLGNTAAILTPLTDSKIISSHLPKEAISGL-VCLVNCAIGMVFTMEAGNYWFDI 459

Query: 473 MDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFF 532
            ++YAA+ SL++I  +  +A+ Y+YG R +  D++ M G     ++++ W  VSP +I  
Sbjct: 460 FNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVS 519

Query: 533 ILVFTVIQYQPITYNHYQ-------------YPGWAVAIGFLMALSSVLCIPLYAM---- 575
           + VF +  Y       YQ             YP +A+A+  L+  SS +CIPL A+    
Sbjct: 520 LFVFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFV 579

Query: 576 -FRLCRTDGD 584
             RL R D D
Sbjct: 580 QRRLKRGDAD 589


>gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo
           sapiens]
          Length = 555

 Score =  302 bits (774), Expect = 6e-82
 Identities = 191/610 (31%), Positives = 290/610 (47%), Gaps = 139/610 (22%)

Query: 49  WGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQ 108
           W N ++FV   + YAVGLGNVWRFPYLC   GGG+F+ PY IMLI  G+PL ++EL+ GQ
Sbjct: 8   WANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQ 67

Query: 109 FASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCN 167
              QG +G WR ISP   GVG   +VVS ++ +YYNV+   AF+Y F S    LPW+ C 
Sbjct: 68  RMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVC- 126

Query: 168 NPWNTHDCAGVLDASNLTNGSRPAALPSNLSHL-LNHSLQRTSPSEEYWRLYVLKLSDDI 226
                                     P N +H   +   ++ S ++ +W    L +S  +
Sbjct: 127 --------------------------PLNGNHTGYDEECEKASSTQYFWYRKTLNISPSL 160

Query: 227 GNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGA 286
              G V+     CL ++WLVV+LC++RG +S+GK+                         
Sbjct: 161 QENGGVQWEPALCLLLAWLVVYLCILRGTESTGKI------------------------- 195

Query: 287 FDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIIS 346
                       +++   K W +AA+QIF+SLG  +G LI  ASYN+  NNC + ++I+S
Sbjct: 196 ------------EQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVS 243

Query: 347 ITNCATSVYAGFVIFS---------------------------------------ILGFM 367
           + N  TS++A  V FS                                       + G++
Sbjct: 244 LINSFTSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYL 303

Query: 368 ANHLGVDVSRV---------------ADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLI 412
           A+      S +               A  G GLAF+ Y EA+  + +S LWS+L+FFML+
Sbjct: 304 ASAYPSKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLL 363

Query: 413 LLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLL 472
           +LG+G+       ++T + D       L K+    L V +    +G+  T +AG YW  +
Sbjct: 364 MLGIGSMLGNTAAILTPLTDSKIISSHLPKEAISGL-VCLVNCAIGMVFTMEAGNYWFDI 422

Query: 473 MDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFF 532
            ++YAA+ SL++I  +  +A+ Y+YG R +  D++ M G     ++++ W  VSP +I  
Sbjct: 423 FNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVS 482

Query: 533 ILVFTVIQYQPITYNHYQ-------------YPGWAVAIGFLMALSSVLCIPLYAM---- 575
           + VF +  Y       YQ             YP +A+A+  L+  SS +CIPL A+    
Sbjct: 483 LFVFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFV 542

Query: 576 -FRLCRTDGD 584
             RL R D D
Sbjct: 543 QRRLKRGDAD 552


>gi|58219014 solute carrier family 6, member 17 [Homo sapiens]
          Length = 727

 Score =  299 bits (766), Expect = 5e-81
 Identities = 189/631 (29%), Positives = 311/631 (49%), Gaps = 106/631 (16%)

Query: 22  VAPSSPEQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGG 81
           VA  +  +  AV  E    D    R  W ++++++L  +G++VGLGN+WRFPYLC +NGG
Sbjct: 40  VAGEAGGKQKAVEEELDAED----RPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGG 95

Query: 82  GAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGI 140
           GA++ PY ++LI  GIPLFF+EL+ GQ   +G +GVW  I P   G+G+   +V  ++G+
Sbjct: 96  GAYLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGL 155

Query: 141 YYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHL 200
           YYNV+I  + +YFF S  + LPW+ C  P   +    V++A                   
Sbjct: 156 YYNVIIGWSIFYFFKSFQYPLPWSEC--PVVRNGSVAVVEAE------------------ 195

Query: 201 LNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGK 260
                +++S +  +W    L +SD I   G +   +  CL V+W +V + +++G++SSGK
Sbjct: 196 ----CEKSSATTYFWYREALDISDSISESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGK 251

Query: 261 VVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGC 320
           V+YF++ FPYVVL    VRG+ L GA DGI++  TP+ DK+L+ +VW +AA+Q+F++LG 
Sbjct: 252 VMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGL 311

Query: 321 AWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVAD 380
            +GG+I  +SYNK  NNC+ D+ ++S  N  TSV A  V+F++LGF AN +  +   V +
Sbjct: 312 GFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKANIM--NEKCVVE 369

Query: 381 HGPGLAFVAYPEALT--LLP----ISPLWSLLFFFMLILL---------GLGTQFCLLET 425
           +   +        L+  L+P     S L +  +  M  ++          LG   CLLE 
Sbjct: 370 NAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQFSALGLDPCLLED 429

Query: 426 LVTAIVDEVGNEWILQKKTY----------VTLGVAVAGFLLGIPLTSQAGIYWLLLMDN 475
            +   V   G  +I   +            V   + +    LG  + + AGI    ++D 
Sbjct: 430 ELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGI-TTPIIDT 488

Query: 476 YAASFSLVVISCIM---CVAIMYIYGHRNYF----------------------------- 503
           +     +  + C +    V ++++    NYF                             
Sbjct: 489 FKVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILENIAVAWIYG 548

Query: 504 -----QDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQY------------QPITY 546
                Q++  MLGF P  F+   W+FVSP  +  +   ++IQ             +    
Sbjct: 549 TKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSAWIKEEAAE 608

Query: 547 NHYQYPGWAVAIGFLMALSSVLCIPLYAMFR 577
            +  +P WA+A+   + + + L IP+  + R
Sbjct: 609 RYLYFPNWAMALLITLIVVATLPIPVVFVLR 639


>gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo
           sapiens]
          Length = 730

 Score =  279 bits (713), Expect = 7e-75
 Identities = 135/327 (41%), Positives = 200/327 (61%), Gaps = 27/327 (8%)

Query: 45  KRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMEL 104
           +R  W ++++++L  VG++VGLGNVWRFPYLC +NGGGA++ PY I+L+  GIPLFF+EL
Sbjct: 60  ERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLEL 119

Query: 105 SFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPW 163
           S GQ   +G +GVW  ISP   G+G+   VV  ++ +YYNV+I  + +YF  S    LPW
Sbjct: 120 SVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPW 179

Query: 164 AYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSH-LLNHSLQRTSPSEEYWRLYVLKL 222
             C                          L  N SH  +    +++S +  YW    L +
Sbjct: 180 DQC-------------------------PLVKNASHTFVEPECEQSSATTYYWYREALNI 214

Query: 223 SDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVT 282
           S  I   G +   +  CL  +W++V L +I+G++SSGK++YF++ FPYVVL    +R   
Sbjct: 215 SSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFL 274

Query: 283 LEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDS 342
           L G+ DGI +  TP+ + +LE KVW +AA+Q+F++LG  +GG+I  +SYNK  NNC+ D+
Sbjct: 275 LNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDA 334

Query: 343 VIISITNCATSVYAGFVIFSILGFMAN 369
           V++S  N  TSV A  V+F++LGF AN
Sbjct: 335 VLVSFINFFTSVLATLVVFAVLGFKAN 361



 Score =  127 bits (319), Expect = 3e-29
 Identities = 63/211 (29%), Positives = 119/211 (56%), Gaps = 17/211 (8%)

Query: 379 ADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEW 438
           A  G GLAF+A+ EA+T  P SP WS++FF ML+ LGLG+ F  +E +VT IVD      
Sbjct: 435 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDT----- 489

Query: 439 ILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYG 498
              +K  +T+   +  F +G+    ++G Y++ + D+Y+A+  L+++  +  +A+ ++YG
Sbjct: 490 FKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVCFVYG 549

Query: 499 HRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQ--YQPITYNHY------- 549
              + +D++ MLGF P  ++   W+++SP ++  +L+ +V+     P  YN +       
Sbjct: 550 IDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKASE 609

Query: 550 ---QYPGWAVAIGFLMALSSVLCIPLYAMFR 577
               YP W + +   + + ++L +P+  + R
Sbjct: 610 EFLSYPTWGLVVCVSLVVFAILPVPVVFIVR 640


>gi|55749589 solute carrier family 6, member 16 [Homo sapiens]
          Length = 736

 Score =  223 bits (569), Expect = 3e-58
 Identities = 159/622 (25%), Positives = 277/622 (44%), Gaps = 107/622 (17%)

Query: 35  SEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIF 94
           +E  + +  L R  W ++ E++L  VG+++    +WRF YL   +GG +F   Y  ML  
Sbjct: 92  TEKKESEVLLARPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFL 151

Query: 95  CGIPLFFMELSFGQFASQGCLGVWRI-SPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYF 153
            G+PL F+E++ GQ   QG +GVW+I +P   GVGY   +V   +G+Y+NVV     +Y 
Sbjct: 152 VGVPLLFLEMAAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYM 211

Query: 154 FSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEE 213
             S    +PW  C    N+             +G  P               +RT+PS  
Sbjct: 212 SQSFQFPVPWEKCPLTMNS-------------SGFDPEC-------------ERTTPSIY 245

Query: 214 YWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVL 273
           +W    LK SD I + G     L+    + W +V   +I G+KS+GKV+Y     P  ++
Sbjct: 246 FWYQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLLPCFII 305

Query: 274 TILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGG--------- 324
              F+R + LEGA  G+   +  +   +    VW  A  Q+  + G   G          
Sbjct: 306 VGFFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASLASYMP 365

Query: 325 ----------------LITMASYNKF-------------HNNCYRDS-VIISITNCA--- 351
                           L+T+  +  F             H  C R++ +++ + N     
Sbjct: 366 QSNNCLSDAFLVSVINLLTLLVFTSFNFCVLGFWATVITHRCCERNAEILLKLINLGKLP 425

Query: 352 -------------TSVYAGFV------IFSILGFMANHLGVDVSRV-ADHGPGLAFVAYP 391
                        TS+Y  ++      I S++        ++   + A  GP  AF+++ 
Sbjct: 426 PDAKPPVNLLYNPTSIYNAWLSGLPQHIKSMVLREVTECNIETQFLKASEGPKFAFLSFV 485

Query: 392 EALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTL-GV 450
           EA++ LP S  WS +FF ML+ +GL +   +++ ++T + D        +K T + + GV
Sbjct: 486 EAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGIITPLQDTFS---FFRKHTKLLIVGV 542

Query: 451 AVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMML 510
            +  F+ G+  T  +G Y++ L+ +Y   F ++V+     +A+ + YG R +  D+ ++L
Sbjct: 543 FLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIVVVVFETMAVSWAYGARRFLADLTILL 602

Query: 511 GFPPPLFFQICWRFVSPAIIFFILVFTVIQ--YQPITYNHYQ----------YPGWAVAI 558
           G P    F   W  + P ++  I V  ++    +PITY  +           YP WA+ +
Sbjct: 603 GHPISPIFGWLWPHLCPVVLLIIFVTMMVHLCMKPITYMSWDSSTSKEVLRPYPPWALLL 662

Query: 559 GFLMALSSVLCIPLYAMFRLCR 580
             ++ L +++ +P+ A F  CR
Sbjct: 663 --MITLFAIVILPIPAYFVYCR 682


>gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo
           sapiens]
          Length = 623

 Score =  210 bits (534), Expect = 4e-54
 Identities = 108/276 (39%), Positives = 159/276 (57%), Gaps = 27/276 (9%)

Query: 96  GIPLFFMELSFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFF 154
           GIPLFF+ELS GQ   +G +GVW  ISP   G+G+   VV  ++ +YYNV+I  + +YF 
Sbjct: 4   GIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFS 63

Query: 155 SSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSH-LLNHSLQRTSPSEE 213
            S    LPW  C                          L  N SH  +    +++S +  
Sbjct: 64  QSFQQPLPWDQC-------------------------PLVKNASHTFVEPECEQSSATTY 98

Query: 214 YWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVL 273
           YW    L +S  I   G +   +  CL  +W++V L +I+G++SSGK++YF++ FPYVVL
Sbjct: 99  YWYREALNISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVL 158

Query: 274 TILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNK 333
               +R   L G+ DGI +  TP+ + +LE KVW +AA+Q+F++LG  +GG+I  +SYNK
Sbjct: 159 ICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNK 218

Query: 334 FHNNCYRDSVIISITNCATSVYAGFVIFSILGFMAN 369
             NNC+ D+V++S  N  TSV A  V+F++LGF AN
Sbjct: 219 RDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKAN 254



 Score =  127 bits (319), Expect = 3e-29
 Identities = 63/211 (29%), Positives = 119/211 (56%), Gaps = 17/211 (8%)

Query: 379 ADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEW 438
           A  G GLAF+A+ EA+T  P SP WS++FF ML+ LGLG+ F  +E +VT IVD      
Sbjct: 328 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDT----- 382

Query: 439 ILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYG 498
              +K  +T+   +  F +G+    ++G Y++ + D+Y+A+  L+++  +  +A+ ++YG
Sbjct: 383 FKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVCFVYG 442

Query: 499 HRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQ--YQPITYNHY------- 549
              + +D++ MLGF P  ++   W+++SP ++  +L+ +V+     P  YN +       
Sbjct: 443 IDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKASE 502

Query: 550 ---QYPGWAVAIGFLMALSSVLCIPLYAMFR 577
               YP W + +   + + ++L +P+  + R
Sbjct: 503 EFLSYPTWGLVVCVSLVVFAILPVPVVFIVR 533


>gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo
           sapiens]
          Length = 289

 Score =  169 bits (428), Expect = 7e-42
 Identities = 87/233 (37%), Positives = 131/233 (56%), Gaps = 30/233 (12%)

Query: 45  KRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMEL 104
           +R  W ++++++L  VG++VGLGNVWRFPYLC +NGGGA++ PY I+L+  GIPLFF+EL
Sbjct: 60  ERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLEL 119

Query: 105 SFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPW 163
           S GQ   +G +GVW  ISP   G+G+   VV  ++ +YYNV+I  + +YF  S    LPW
Sbjct: 120 SVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPW 179

Query: 164 AYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSH-LLNHSLQRTSPSEEYWRLYVLKL 222
             C                          L  N SH  +    +++S +  YW    L +
Sbjct: 180 DQC-------------------------PLVKNASHTFVEPECEQSSATTYYWYREALNI 214

Query: 223 SDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTI 275
           S  I   G +   +  CL  +W++V L +I+G++SSGKV   +   P+++L I
Sbjct: 215 SSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKV---SMLEPFLILLI 264


>gi|197276625 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform b [Homo sapiens]
          Length = 200

 Score =  162 bits (410), Expect = 9e-40
 Identities = 71/158 (44%), Positives = 101/158 (63%), Gaps = 1/158 (0%)

Query: 19  HGPVAPSSPEQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYR 78
           H  +   SP ++     E     +  +R  W ++I+FVL+  G  VGLGNVWRFPYLCY+
Sbjct: 14  HKDILKPSPGKSPGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYK 73

Query: 79  NGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVW-RISPMFKGVGYGMMVVSTY 137
           NGGGAF+ PYFI L   G+P+FF+E+  GQ+ S+G +  W +I P+F G+GY  +V+ + 
Sbjct: 74  NGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSL 133

Query: 138 IGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDC 175
           + +YY V++  A YY F S    LPWA+CN+ WNT  C
Sbjct: 134 LNVYYIVILAWATYYLFQSFQKELPWAHCNHSWNTPHC 171


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.327    0.142    0.464 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,405,513
Number of Sequences: 37866
Number of extensions: 1144120
Number of successful extensions: 3893
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 3737
Number of HSP's gapped (non-prelim): 61
length of query: 652
length of database: 18,247,518
effective HSP length: 109
effective length of query: 543
effective length of database: 14,120,124
effective search space: 7667227332
effective search space used: 7667227332
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.