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Search of human proteins with 66529005
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|66529005 ATP-binding cassette, sub-family C, member 5
isoform 1 [Homo sapiens]
(1437 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 2817 0.0
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 1150 0.0
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 1019 0.0
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 1019 0.0
gi|21729876 ATP-binding cassette, sub-family C, member 11 isofor... 949 0.0
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 676 0.0
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 661 0.0
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 655 0.0
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 654 0.0
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 653 0.0
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 647 0.0
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 616 e-176
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 591 e-168
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 558 e-158
gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor... 550 e-156
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 542 e-153
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 542 e-153
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 530 e-150
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 530 e-150
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 474 e-133
gi|66529093 ATP-binding cassette, sub-family C, member 5 isoform... 404 e-112
gi|90421313 cystic fibrosis transmembrane conductance regulator ... 298 2e-80
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor... 281 4e-75
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 239 1e-62
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 238 2e-62
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 235 2e-61
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 228 2e-59
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 205 3e-52
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 204 6e-52
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is... 167 7e-41
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 2817 bits (7303), Expect = 0.0
Identities = 1437/1437 (100%), Positives = 1437/1437 (100%)
Query: 1 MKDIDIGKEYIIPSPGYRSVRERTSTSGTHRDREDSKFRRTRPLECQDALETAARAEGLS 60
MKDIDIGKEYIIPSPGYRSVRERTSTSGTHRDREDSKFRRTRPLECQDALETAARAEGLS
Sbjct: 1 MKDIDIGKEYIIPSPGYRSVRERTSTSGTHRDREDSKFRRTRPLECQDALETAARAEGLS 60
Query: 61 LDASMHSQLRILDEEHPKGKYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLAR 120
LDASMHSQLRILDEEHPKGKYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLAR
Sbjct: 61 LDASMHSQLRILDEEHPKGKYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLAR 120
Query: 121 VAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNEVGPDAASLRRVVWIFCRTRLI 180
VAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNEVGPDAASLRRVVWIFCRTRLI
Sbjct: 121 VAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNEVGPDAASLRRVVWIFCRTRLI 180
Query: 181 LSIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTW 240
LSIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTW
Sbjct: 181 LSIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTW 240
Query: 241 ALNYRTGVRLRGAILTMAFKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGG 300
ALNYRTGVRLRGAILTMAFKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGG
Sbjct: 241 ALNYRTGVRLRGAILTMAFKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGG 300
Query: 301 PVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNE 360
PVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNE
Sbjct: 301 PVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNE 360
Query: 361 VLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSV 420
VLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSV
Sbjct: 361 VLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSV 420
Query: 421 HMTLGFDLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIK 480
HMTLGFDLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIK
Sbjct: 421 HMTLGFDLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIK 480
Query: 481 NKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQA 540
NKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQA
Sbjct: 481 NKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQA 540
Query: 541 VLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSG 600
VLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSG
Sbjct: 541 VLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSG 600
Query: 601 KTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNS 660
KTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNS
Sbjct: 601 KTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNS 660
Query: 661 CCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVG 720
CCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVG
Sbjct: 661 CCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVG 720
Query: 721 NHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATI 780
NHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATI
Sbjct: 721 NHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATI 780
Query: 781 FNNLLLGETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGS 840
FNNLLLGETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGS
Sbjct: 781 FNNLLLGETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGS 840
Query: 841 VPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETS 900
VPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETS
Sbjct: 841 VPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETS 900
Query: 901 VSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPM 960
VSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPM
Sbjct: 901 VSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPM 960
Query: 961 KFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGP 1020
KFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGP
Sbjct: 961 KFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGP 1020
Query: 1021 LVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQEL 1080
LVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQEL
Sbjct: 1021 LVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQEL 1080
Query: 1081 LDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLT 1140
LDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLT
Sbjct: 1081 LDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLT 1140
Query: 1141 GLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEM 1200
GLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEM
Sbjct: 1141 GLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEM 1200
Query: 1201 RYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISD 1260
RYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISD
Sbjct: 1201 RYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISD 1260
Query: 1261 IGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLE 1320
IGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLE
Sbjct: 1261 IGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLE 1320
Query: 1321 SEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCT 1380
SEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCT
Sbjct: 1321 SEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCT 1380
Query: 1381 MLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENKVAVKG 1437
MLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENKVAVKG
Sbjct: 1381 MLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENKVAVKG 1437
>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
Length = 1359
Score = 1150 bits (2975), Expect = 0.0
Identities = 616/1373 (44%), Positives = 874/1373 (63%), Gaps = 62/1373 (4%)
Query: 80 KYHHGLSALKPIRTTSK-HQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSK 138
+Y L + P+R ++ +PVD+AGL S TFSWL+ + +++ L+++ + LS
Sbjct: 24 RYDPSLKTMIPVRPCARLAPNPVDDAGLLSFATFSWLTPVMVKGYRQ-RLTVDTLPPLST 82
Query: 139 HESSDVNCRRLERLWQEELNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPA 198
++SSD N +R LW EE+ VGP+ ASL VVW F RTR+++ IV ++ + GP
Sbjct: 83 YDSSDTNAKRFRVLWDEEVARVGPEKASLSHVVWKFQRTRVLMDIVANILCIIMAAIGPV 142
Query: 199 FMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMA 258
++ +L+ T+ T + + L + L TE + + AL WA+NYRT +RL+ A+ T+
Sbjct: 143 ILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAWAINYRTAIRLKVALSTLV 202
Query: 259 FKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPT 318
F+ ++ K + S+GE++NI S+D +FEAA L A P++ + Y ILGPT
Sbjct: 203 FENLVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFILGPT 262
Query: 319 GFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFS 378
+G +V+++F P MF ++L + FRR + TD+RVQ MNE LT I+ IKMYAW K+F+
Sbjct: 263 ALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFT 322
Query: 379 QSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVT 438
++Q IR ER++LEKAG+ QS +APIV IA V+T S H+ L LTA AF+V+
Sbjct: 323 NTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPVAFSVIA 382
Query: 439 VFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLA 498
+FN M F++ + PFS+K+++EA+V++ R K + + + +P P + + NATL
Sbjct: 383 MFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLANATLT 442
Query: 499 WDSSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPS 558
W+ + S K TPK ++++ KK++ A KG
Sbjct: 443 WEH-----EASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPA-----KG--------ATG 484
Query: 559 PEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGS 618
PEE+ L+ LHSI +++GK++GICG+VGSGK+SL++A+LGQM L +G
Sbjct: 485 PEEQSDS--------LKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGV 536
Query: 619 IAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEI 678
+A++GT AYV+QQAWI + +R+NILFG++YD +RY + C L+ DL+ LP DLTEI
Sbjct: 537 VAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEI 596
Query: 679 GERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVL 738
GERG NLSGGQRQRISLARA+YSDR +Y+LDDPLSA+DAHVG H+F I+K L+ KTV+
Sbjct: 597 GERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVV 656
Query: 739 FVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNL--LLGETPPVEINS 796
VTHQLQ+L CDEVI +++G I E+GTH+ELM G YA + +NL L + P N+
Sbjct: 657 LVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNA 716
Query: 797 ------------KKETSG------SQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQ 838
++E +G +K + K +TGS + K E QL+Q E +
Sbjct: 717 AMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVD--TKVPEHQLIQTESPQE 774
Query: 839 GSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNE 898
G+V W Y YI+A+GG L L + LF+L +GS AFS WWL W+ +GS T +GN
Sbjct: 775 GTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNR 834
Query: 899 TSVS-DSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILR 957
T ++ + Y +Y SM ML+ +G VF K TL ASS LHD +F +IL+
Sbjct: 835 TMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILK 894
Query: 958 SPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVA 1017
SPM FFDTTPTGR++NRFSKDMDE+DVRLPF AE F+Q +V F + ++A VFP L+
Sbjct: 895 SPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLV 954
Query: 1018 VGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRY 1077
V L + F +L + ++ELK+++N+++SP+ +HITSS+QGL IHAY K + + +
Sbjct: 955 VASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKKESCITYH 1014
Query: 1078 QELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAV 1137
F CA+RW A+R+D++ L T L++ L I + GL++SY +
Sbjct: 1015 ----------LLYFNCALRWFALRMDVLMNILTFTVALLVTLSFSSISTSSKGLSLSYII 1064
Query: 1138 QLTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFEN 1197
QL+GL Q VR +ET+A+FTSVE + YI T E +K DWP GE+TF +
Sbjct: 1065 QLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKVGTCPKDWPSRGEITFRD 1124
Query: 1198 AEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVR 1257
+MRYR+N PLVL ++ I+ + +GIVGRTGSGKSSLGMALFRLVE + G I ID V
Sbjct: 1125 YQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVD 1184
Query: 1258 ISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPL 1317
I + L DLR+KL++IPQ+PVLF GTVR NLDPF +T++ +W LERT M++ I +LP
Sbjct: 1185 ICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPE 1244
Query: 1318 KLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFA 1377
KL++EV ENG+NFSVGERQLLC+ARALLR+ KI++LDEATA+MD++TD L+Q TI++AF
Sbjct: 1245 KLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDAFK 1304
Query: 1378 DCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAE 1430
CT+LTIAHRL+TVL D ++V+ G+V+EFD P VL S F AM AAE
Sbjct: 1305 GCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSAF-AMLLAAE 1356
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 1019 bits (2636), Expect = 0.0
Identities = 554/1360 (40%), Positives = 818/1360 (60%), Gaps = 41/1360 (3%)
Query: 77 PKGKYHHGLSALKPIRTTSKHQ--HPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVW 134
P GKY L + P R + P+DNAGLFS +T SWL+ L + + L +
Sbjct: 60 PWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLM-IQSLRSRLDENTIP 118
Query: 135 SLSKHESSDVNCRRLERLWQEELNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGF 194
LS H++SD N +RL RLW+EE++ G + AS+ V+ F RTRLI + + +A
Sbjct: 119 PLSVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASV 178
Query: 195 SGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAI 254
GP ++ +LEY++ N+ + + L L L+E V+S S + +W +N RT +R R A+
Sbjct: 179 LGPILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAV 238
Query: 255 LTMAFKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVII 314
+ AF+K+++ K++ + GE I+ + D +FE G L+ ++ I + I
Sbjct: 239 SSFAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFI 298
Query: 315 LGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWV 374
+G T F+ ++L +P +F +R+ + +D+R++ +EVLT IK IKMY W
Sbjct: 299 IGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWE 358
Query: 375 KAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAF 434
K F++ ++ +R +ER++LEK G QS+T I+ +A+ V +H +L LTA+ AF
Sbjct: 359 KPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAF 418
Query: 435 TVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKN 494
+++ N + ++ P +VK L+ + AV RFK FL E P + +
Sbjct: 419 SMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEE 478
Query: 495 ATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSD 554
ATL+W + I N +++++ AS G A+ E++G+ L
Sbjct: 479 ATLSWQQTCPGIVNG---ALELERNGHASEG--------MTRPRDALGPEEEGNSL---- 523
Query: 555 ERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTL 614
PE LH I+L + +G ++G+CG+ GSGK+SL+SAIL +M L
Sbjct: 524 ---GPE-----------------LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHL 563
Query: 615 LEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSD 674
LEGS+ + G+ AYV QQAWI++ +R+NIL G YD+ RY VL+ C L DL +LP D
Sbjct: 564 LEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGD 623
Query: 675 LTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKS 734
+TEIGERG NLSGGQ+QRISLARA+YSDR IY+LDDPLSA+DAHVG HIF I+K L+
Sbjct: 624 MTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRG 683
Query: 735 KTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEI 794
KTV+ VTHQLQYL C ++I ++ G I E GTH ELM G YA + + T +
Sbjct: 684 KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQ 743
Query: 795 NSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAG 854
++ K + +SQ AV E QL Q EE +GS+ W VY YIQAAG
Sbjct: 744 DTAKIAEKPKVESQALATSLEESLNGNAV--PEHQLTQEEEMEEGSLSWRVYHHYIQAAG 801
Query: 855 GPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVS-DSMKDNPHMQY 913
G + +I +L V T FS WWLSYW++QGSG + N T ++ DNP + +
Sbjct: 802 GYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSF 861
Query: 914 YASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILN 973
Y +Y L+ +++ + +F K T +AS+ LH++LF ++ R PM FFDT P GR+LN
Sbjct: 862 YQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLN 921
Query: 974 RFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSR 1033
F+ D++++D LP +E F+ ++V + +++ + P+ L+ ++++ + +++ +
Sbjct: 922 CFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFK 981
Query: 1034 VLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTC 1093
I KRL+N ++SP SHI +S+QGL++IH Y K ++F+ +++ L D LF
Sbjct: 982 KAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLS 1041
Query: 1094 AMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASET 1153
+ RW+A+RL++++ + L + P ++ +A++ +QL FQ T R+ ET
Sbjct: 1042 STRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLET 1101
Query: 1154 EARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKV 1213
EA+FT+VERI Y+K EAP ++ + WPQ GE+ F++ M+YR+N P VL +
Sbjct: 1102 EAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGI 1161
Query: 1214 SFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSII 1273
+ TI+ E +GIVGRTGSGKSSLGMALFRLVE G I IDGV I IGL DLRSKLS+I
Sbjct: 1162 NLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVI 1221
Query: 1274 PQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVG 1333
PQ+PVL SGT+R NLDPF+++T+ QIWDALERT + + I++ P KL ++V+ENG NFSVG
Sbjct: 1222 PQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVG 1281
Query: 1334 ERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLG 1393
ERQLLCIARA+LR+ KI+++DEATA++D ETD LIQ TIREAF CT+L IAHR+ TVL
Sbjct: 1282 ERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLN 1341
Query: 1394 SDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENKV 1433
D I+V+ G+VVEFD P VL S F A+ A A + +
Sbjct: 1342 CDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSSL 1381
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 1019 bits (2636), Expect = 0.0
Identities = 554/1360 (40%), Positives = 818/1360 (60%), Gaps = 41/1360 (3%)
Query: 77 PKGKYHHGLSALKPIRTTSKHQ--HPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVW 134
P GKY L + P R + P+DNAGLFS +T SWL+ L + + L +
Sbjct: 60 PWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLM-IQSLRSRLDENTIP 118
Query: 135 SLSKHESSDVNCRRLERLWQEELNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGF 194
LS H++SD N +RL RLW+EE++ G + AS+ V+ F RTRLI + + +A
Sbjct: 119 PLSVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASV 178
Query: 195 SGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAI 254
GP ++ +LEY++ N+ + + L L L+E V+S S + +W +N RT +R R A+
Sbjct: 179 LGPILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAV 238
Query: 255 LTMAFKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVII 314
+ AF+K+++ K++ + GE I+ + D +FE G L+ ++ I + I
Sbjct: 239 SSFAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFI 298
Query: 315 LGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWV 374
+G T F+ ++L +P +F +R+ + +D+R++ +EVLT IK IKMY W
Sbjct: 299 IGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWE 358
Query: 375 KAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAF 434
K F++ ++ +R +ER++LEK G QS+T I+ +A+ V +H +L LTA+ AF
Sbjct: 359 KPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAF 418
Query: 435 TVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKN 494
+++ N + ++ P +VK L+ + AV RFK FL E P + +
Sbjct: 419 SMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEE 478
Query: 495 ATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSD 554
ATL+W + I N +++++ AS G A+ E++G+ L
Sbjct: 479 ATLSWQQTCPGIVNG---ALELERNGHASEG--------MTRPRDALGPEEEGNSL---- 523
Query: 555 ERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTL 614
PE LH I+L + +G ++G+CG+ GSGK+SL+SAIL +M L
Sbjct: 524 ---GPE-----------------LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHL 563
Query: 615 LEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSD 674
LEGS+ + G+ AYV QQAWI++ +R+NIL G YD+ RY VL+ C L DL +LP D
Sbjct: 564 LEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGD 623
Query: 675 LTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKS 734
+TEIGERG NLSGGQ+QRISLARA+YSDR IY+LDDPLSA+DAHVG HIF I+K L+
Sbjct: 624 MTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRG 683
Query: 735 KTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEI 794
KTV+ VTHQLQYL C ++I ++ G I E GTH ELM G YA + + T +
Sbjct: 684 KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQ 743
Query: 795 NSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAG 854
++ K + +SQ AV E QL Q EE +GS+ W VY YIQAAG
Sbjct: 744 DTAKIAEKPKVESQALATSLEESLNGNAV--PEHQLTQEEEMEEGSLSWRVYHHYIQAAG 801
Query: 855 GPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVS-DSMKDNPHMQY 913
G + +I +L V T FS WWLSYW++QGSG + N T ++ DNP + +
Sbjct: 802 GYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSF 861
Query: 914 YASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILN 973
Y +Y L+ +++ + +F K T +AS+ LH++LF ++ R PM FFDT P GR+LN
Sbjct: 862 YQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLN 921
Query: 974 RFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSR 1033
F+ D++++D LP +E F+ ++V + +++ + P+ L+ ++++ + +++ +
Sbjct: 922 CFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFK 981
Query: 1034 VLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTC 1093
I KRL+N ++SP SHI +S+QGL++IH Y K ++F+ +++ L D LF
Sbjct: 982 KAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLS 1041
Query: 1094 AMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASET 1153
+ RW+A+RL++++ + L + P ++ +A++ +QL FQ T R+ ET
Sbjct: 1042 STRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLET 1101
Query: 1154 EARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKV 1213
EA+FT+VERI Y+K EAP ++ + WPQ GE+ F++ M+YR+N P VL +
Sbjct: 1102 EAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGI 1161
Query: 1214 SFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSII 1273
+ TI+ E +GIVGRTGSGKSSLGMALFRLVE G I IDGV I IGL DLRSKLS+I
Sbjct: 1162 NLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVI 1221
Query: 1274 PQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVG 1333
PQ+PVL SGT+R NLDPF+++T+ QIWDALERT + + I++ P KL ++V+ENG NFSVG
Sbjct: 1222 PQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVG 1281
Query: 1334 ERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLG 1393
ERQLLCIARA+LR+ KI+++DEATA++D ETD LIQ TIREAF CT+L IAHR+ TVL
Sbjct: 1282 ERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLN 1341
Query: 1394 SDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENKV 1433
D I+V+ G+VVEFD P VL S F A+ A A + +
Sbjct: 1342 CDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSSL 1381
>gi|21729876 ATP-binding cassette, sub-family C, member 11 isoform b
[Homo sapiens]
Length = 1344
Score = 949 bits (2453), Expect = 0.0
Identities = 528/1360 (38%), Positives = 785/1360 (57%), Gaps = 79/1360 (5%)
Query: 77 PKGKYHHGLSALKPIRTTSKHQ--HPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVW 134
P GKY L + P R + P+DNAGLFS +T SWL+ L + + L +
Sbjct: 60 PWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLM-IQSLRSRLDENTIP 118
Query: 135 SLSKHESSDVNCRRLERLWQEELNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGF 194
LS H++SD N +RL RLW+EE++ G + AS+ V+ F RTRLI + + +A
Sbjct: 119 PLSVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASV 178
Query: 195 SGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAI 254
GP ++ +LEY++ N+ + + L L L+E V+S S + +W +N RT +R R A+
Sbjct: 179 LGPILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAV 238
Query: 255 LTMAFKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVII 314
+ AF+K+++ K++ + GE I+ + D +FE G L+ ++ I + I
Sbjct: 239 SSFAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFI 298
Query: 315 LGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWV 374
+G T F+ ++L +P +F +R+ + +D+R++ +EVLT IK IKMY W
Sbjct: 299 IGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWE 358
Query: 375 KAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAF 434
K F++ ++ +R +ER++LEK G QS+T I+ +A+ V +H +L LTA+ AF
Sbjct: 359 KPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAF 418
Query: 435 TVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKN 494
+++ N + ++ P +VK L+ + AV RFK FL E P + +
Sbjct: 419 SMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEE 478
Query: 495 ATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSD 554
ATL+W + I N +++++ AS G A+ E++G+ L
Sbjct: 479 ATLSWQQTCPGIVNG---ALELERNGHASEG--------MTRPRDALGPEEEGNSL---- 523
Query: 555 ERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTL 614
PE LH I+L + +G ++G+CG+ GSGK+SL+SAIL +M L
Sbjct: 524 ---GPE-----------------LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHL 563
Query: 615 LEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSD 674
LEGS+ + G+ AYV QQAWI++ +R+NIL G YD+ RY VL+ C L DL +LP D
Sbjct: 564 LEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGD 623
Query: 675 LTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKS 734
+TEIGERG NLSGGQ+QRISLARA+YSDR IY+LDDPLSA+DAHVG HIF I+K L+
Sbjct: 624 MTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRG 683
Query: 735 KTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEI 794
KTV+ VTHQLQYL C ++I ++ G I E GTH ELM G YA + + T +
Sbjct: 684 KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQ 743
Query: 795 NSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAG 854
++ K + +SQ AV E QL Q EE +GS+ W VY YIQAAG
Sbjct: 744 DTAKIAEKPKVESQALATSLEESLNGNAV--PEHQLTQEEEMEEGSLSWRVYHHYIQAAG 801
Query: 855 GPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVS-DSMKDNPHMQY 913
G + +I +L V T FS WWLSYW++QGSG + N T ++ DNP + +
Sbjct: 802 GYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSF 861
Query: 914 YASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILN 973
Y +Y L+ +++ + +F K T +AS+ LH++LF ++ R PM FFDT P GR+LN
Sbjct: 862 YQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLN 921
Query: 974 RFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSR 1033
F+ D++++D LP +E F+ ++V + +++ + P+ L+ ++++ + +++ +
Sbjct: 922 CFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFK 981
Query: 1034 VLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTC 1093
I KRL+N ++SP SHI +S+QGL++IH Y K ++F+ +++ L D LF
Sbjct: 982 KAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLS 1041
Query: 1094 AMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASET 1153
+ RW+A+RL++++ + L + P ++ +A++ +QL FQ T R+ ET
Sbjct: 1042 STRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLET 1101
Query: 1154 EARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKV 1213
EA+FT+VERI Y+K EAP ++ + WPQ GE+ F++ M+YR+N P VL +
Sbjct: 1102 EAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGI 1161
Query: 1214 SFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSII 1273
+ TI+ E +GIVGRTGSGKSSLGMALFRLVE G I IDGV I IGL DLRSKLS+I
Sbjct: 1162 NLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVI 1221
Query: 1274 PQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVG 1333
PQ+PVL SGT+R NLDPF+++T+ QIWDALERT + +
Sbjct: 1222 PQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKA---------------------- 1259
Query: 1334 ERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLG 1393
I+++DEATA++D ETD LIQ TIREAF CT+L IAHR+ TVL
Sbjct: 1260 ----------------IILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLN 1303
Query: 1394 SDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENKV 1433
D I+V+ G+VVEFD P VL S F A+ A A + +
Sbjct: 1304 CDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSSL 1343
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 676 bits (1745), Expect = 0.0
Identities = 439/1385 (31%), Positives = 723/1385 (52%), Gaps = 118/1385 (8%)
Query: 106 LFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNEVGPDAA 165
L S T+ W+++L AHKK + ++ + L + N L+ ++E+ +V D
Sbjct: 222 LLSKATYWWMNTLIISAHKK-PIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVA-DHP 279
Query: 166 SLRRVVWI-----FCRTRLILSIVCLMITQLAGFSGP---AFMVKHLLEYTQATESN--- 214
+ +W+ F R ++LS + L GF+GP + +V+ + E T +
Sbjct: 280 NRTPSIWLAMYRAFGRP-ILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGI 338
Query: 215 ---------LQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKL 265
L+ + +L + L L I++ L ++ + TG+ LRGA+L M + KIL+L
Sbjct: 339 SETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRL 398
Query: 266 K----NIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFL 321
++ E +LG++ N+ + + ++ + L PV I+G+I +LG + +
Sbjct: 399 STSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALV 458
Query: 322 GSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSV 381
G+AV +L P F + A ++ + + ER++K NE+L IK +K+YAW F +SV
Sbjct: 459 GAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSV 518
Query: 382 QKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHM-TLGFDLTAAQAFTVVTVF 440
++ R +E L+ + S+++ + + + A + TF H G +L A+AF +++F
Sbjct: 519 EETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLF 578
Query: 441 NSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWD 500
+ + L + V+ +A ++V + L +E+ +W
Sbjct: 579 HILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEI------------------GDDSWR 620
Query: 501 SSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDE----- 555
+ SS+ E ++ + + + +Q G LDS E
Sbjct: 621 TGESSLPF-------------------ESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRR 661
Query: 556 -RPSPEEEEGKHIHLGHLRLQR---TLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQ 611
RP+ E+ + G+ TL +ID+ I G+L I G VG GK+SL+ AILG+
Sbjct: 662 LRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGE 721
Query: 612 MTLLEGSIAISG-----------------TFAYVAQQAWILNATLRDNILFGKEYDEERY 654
M LEG + S + AY AQ+ W+LNAT+ +NI FG ++++RY
Sbjct: 722 MQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRY 781
Query: 655 NSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSA 714
+V ++C L+PD+ +LP D TEIGERG NLSGGQRQRI +ARALY + +I LDDP SA
Sbjct: 782 KAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSA 841
Query: 715 LDAHVGNHIFNSAIRKHLKS--KTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMN 772
LD H+ +H+ I K L+ +T++ VTH+LQYL D +I MK+G + GT +++
Sbjct: 842 LDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQT 901
Query: 773 LNGDYATIFNNLLLGETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQ 832
+ + + L+ + +E + + + + ++K+ + + K + + EE + +
Sbjct: 902 KDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEE 961
Query: 833 LEEKGQGSV-------PWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIK 885
E+ +V PW Y+ + G L L+I + + + A +WL+ W
Sbjct: 962 DEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAID-YWLATWTS 1020
Query: 886 QGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASS 945
+ S N T + ++T YY + +++ + L + + L A+
Sbjct: 1021 EYSINNT-GKADQT-------------YYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAK 1066
Query: 946 RLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVG 1005
LH L +I+ P++FFDTTP G ILNRFS D + +D +P E ++ +L +G
Sbjct: 1067 NLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIG 1126
Query: 1006 MIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIH 1065
MI+ P FLVA+ PL + F + RV ++L+ LD+ TQ P L H + + +GL TI
Sbjct: 1127 MISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIR 1186
Query: 1066 AYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIP 1125
A+ F R EL D N + + A RWL VR D + ++ T I + G
Sbjct: 1187 AFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTAS--IASISGSSN 1244
Query: 1126 PAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSP 1185
GL + YA+ +T + VR ++ E + +V+++N ++ S +
Sbjct: 1245 SGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPE 1304
Query: 1186 DWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVE 1245
WPQEGE+ + +RY NL VLK V IKP +K+GI GRTGSGKSSL +A FR+V+
Sbjct: 1305 HWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVD 1364
Query: 1246 LSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALER 1305
+ G I IDG+ IS + L LRS+LSII Q+P+LFSG++R NLDP + T+D++W+ALE
Sbjct: 1365 IFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEI 1424
Query: 1306 THMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETD 1365
+K + LP L++ V E G+NFSVG+RQL C+ARA +R ILI+DEATA++D T+
Sbjct: 1425 AQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATE 1484
Query: 1366 LLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAM 1425
++Q+ + AFAD T++TIAHR+HT+L +D ++V+ +G ++E+DTP LL+ ++ F A
Sbjct: 1485 NILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVF-AS 1543
Query: 1426 FAAAE 1430
F A+
Sbjct: 1544 FVRAD 1548
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 661 bits (1705), Expect = 0.0
Identities = 432/1377 (31%), Positives = 715/1377 (51%), Gaps = 117/1377 (8%)
Query: 106 LFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNEVGPDAA 165
L S T+ W+++L AHKK + ++ + L + N L+ ++E+ +V D
Sbjct: 222 LLSKATYWWMNTLIISAHKK-PIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVA-DHP 279
Query: 166 SLRRVVWI-----FCRTRLILSIVCLMITQLAGFSGP---AFMVKHLLEYTQATESN--- 214
+ +W+ F R ++LS + L GF+GP + +V+ + E T +
Sbjct: 280 NRTPSIWLAMYRAFGRP-ILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGI 338
Query: 215 ---------LQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKL 265
L+ + +L + L L I++ L ++ + TG+ LRGA+L M + KIL+L
Sbjct: 339 SETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRL 398
Query: 266 K----NIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFL 321
++ E +LG++ N+ + + ++ + L PV I+G+I +LG + +
Sbjct: 399 STSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALV 458
Query: 322 GSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSV 381
G+AV +L P F + A ++ + + ER++K NE+L IK +K+YAW F +SV
Sbjct: 459 GAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSV 518
Query: 382 QKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHM-TLGFDLTAAQAFTVVTVF 440
++ R +E L+ + S+++ + + + A + TF H G +L A+AF +++F
Sbjct: 519 EETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLF 578
Query: 441 NSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWD 500
+ + L + V+ +A ++V + L +E+ +W
Sbjct: 579 HILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEI------------------GDDSWR 620
Query: 501 SSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDE----- 555
+ SS+ E ++ + + + +Q G LDS E
Sbjct: 621 TGESSLPF-------------------ESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRR 661
Query: 556 -RPSPEEEEGKHIHLGHLRLQR---TLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQ 611
RP+ E+ + G+ TL +ID+ I G+L I G VG GK+SL+ AILG+
Sbjct: 662 LRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGE 721
Query: 612 MTLLEGSIAISG-----------------TFAYVAQQAWILNATLRDNILFGKEYDEERY 654
M LEG + S + AY AQ+ W+LNAT+ +NI FG ++++RY
Sbjct: 722 MQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRY 781
Query: 655 NSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSA 714
+V ++C L+PD+ +LP D TEIGERG NLSGGQRQRI +ARALY + +I LDDP SA
Sbjct: 782 KAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSA 841
Query: 715 LDAHVGNHIFNSAIRKHLKS--KTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMN 772
LD H+ +H+ I K L+ +T++ VTH+LQYL D +I MK+G + GT +++
Sbjct: 842 LDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQT 901
Query: 773 LNGDYATIFNNLLLGETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQ 832
+ + + L+ + +E + + + + ++K+ + + K + + EE + +
Sbjct: 902 KDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEE 961
Query: 833 LEEKGQGSV-------PWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIK 885
E+ +V PW Y+ + G L L+I + + + A +WL+ W
Sbjct: 962 DEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAID-YWLATWTS 1020
Query: 886 QGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASS 945
+ S N T + ++T YY + +++ + L + + L A+
Sbjct: 1021 EYSINNT-GKADQT-------------YYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAK 1066
Query: 946 RLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVG 1005
LH L +I+ P++FFDTTP G ILNRFS D + +D +P E ++ +L +G
Sbjct: 1067 NLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIG 1126
Query: 1006 MIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIH 1065
MI+ P FLVA+ PL + F + RV ++L+ LD+ TQ P L H + + +GL TI
Sbjct: 1127 MISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIR 1186
Query: 1066 AYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIP 1125
A+ F R EL D N + + A RWL VR D + ++ T I + G
Sbjct: 1187 AFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTAS--IASISGSSN 1244
Query: 1126 PAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSP 1185
GL + YA+ +T + VR ++ E + +V+++N ++ S +
Sbjct: 1245 SGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPE 1304
Query: 1186 DWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVE 1245
WPQEGE+ + +RY NL VLK V IKP +K+GI GRTGSGKSSL +A FR+V+
Sbjct: 1305 HWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVD 1364
Query: 1246 LSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALER 1305
+ G I IDG+ IS + L LRS+LSII Q+P+LFSG++R NLDP + T+D++W+ALE
Sbjct: 1365 IFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEI 1424
Query: 1306 THMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETD 1365
+K + LP L++ V E G+NFSVG+RQL C+ARA +R ILI+DEATA++D T+
Sbjct: 1425 AQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATE 1484
Query: 1366 LLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRF 1422
++Q+ + AFAD T++TIAHR+ +++ + ++V ++G +VE DT LL++ + F
Sbjct: 1485 NILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLF 1541
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 655 bits (1689), Expect = 0.0
Identities = 373/883 (42%), Positives = 534/883 (60%), Gaps = 52/883 (5%)
Query: 577 TLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILN 636
TL+ I I EG LV + G VG GK+SL+SA+L +M +EG +AI G+ AYV QQAWI N
Sbjct: 660 TLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQN 719
Query: 637 ATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLA 696
+LR+NILFG + +E Y SV+ +C L PDL ILPS D TEIGE+G NLSGGQ+QR+SLA
Sbjct: 720 DSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLA 779
Query: 697 RALYSDRSIYILDDPLSALDAHVGNHIFNSAI--RKHLKSKTVLFVTHQLQYLVDCDEVI 754
RA+YS+ IY+ DDPLSA+DAHVG HIF + I + LK+KT + VTH + YL D +I
Sbjct: 780 RAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVII 839
Query: 755 FMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPP-VEINSKKETSGSQKKSQ----- 808
M G I+E G+++EL+ +G +A E E N SG K+++
Sbjct: 840 VMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENG 899
Query: 809 ----DKGPK----------------------TGSVKKEKAVKPEEGQLVQLEEKGQGSVP 842
D K T ++K +A K E +L++ ++ G V
Sbjct: 900 MLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVK 959
Query: 843 WSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVS 902
SVY Y++A G ++FL I LFM N S S +WLS W N T T V
Sbjct: 960 LSVYWDYMKAIGLFISFLSIF-LFMCNHVSALASNYWLSLWTDDPIVNGTQ---EHTKVR 1015
Query: 903 DSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKF 962
S+ + +++ SMAV + G + AS LH +L ILRSPM F
Sbjct: 1016 LSVYGALGISQGIAVFGYSMAVSI------------GGILASRCLHVDLLHSILRSPMSF 1063
Query: 963 FDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLV 1022
F+ TP+G ++NRFSK++D VD +P +MF+ ++ V +I P + + PL
Sbjct: 1064 FERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLG 1123
Query: 1023 ILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLD 1082
+++ + R+LKRL+++++SP SH ++ G++ I A+ + + F+H+ +D
Sbjct: 1124 LIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVD 1183
Query: 1083 DNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGL 1142
+NQ ++ A RWLAVRL+ + ++ L V+ + GL++SY++Q+T
Sbjct: 1184 ENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTY 1243
Query: 1143 FQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRY 1202
+ VR++SE E +VER+ Y +T EAP +I+ AP WPQ G V F N +RY
Sbjct: 1244 LNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQIQETAPPSSWPQVGRVEFRNYCLRY 1302
Query: 1203 RENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIG 1262
RE+L VL+ ++ TI EK+GIVGRTG+GKSSL + LFR+ E + G I IDG+ I+ IG
Sbjct: 1303 REDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIG 1362
Query: 1263 LADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESE 1322
L DLR K++IIPQ+PVLFSG++R NLDPF+QY+++++W +LE H+K+ ++ LP KL+ E
Sbjct: 1363 LHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHE 1422
Query: 1323 VMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTML 1382
E G+N SVG+RQL+C+ARALLR KIL+LDEATAA+D ETD LIQ TIR F DCT+L
Sbjct: 1423 CAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVL 1482
Query: 1383 TIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAM 1425
TIAHRL+T++ R++VL +G++ E+ PS LL FY+M
Sbjct: 1483 TIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL-QQRGLFYSM 1524
Score = 146 bits (369), Expect = 1e-34
Identities = 113/450 (25%), Positives = 210/450 (46%), Gaps = 49/450 (10%)
Query: 100 PVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNE 159
P +A S +TF W++ L +++ L D+WSL+K ++S+ L + W++E +
Sbjct: 209 PESSASFLSRITFWWITGLIVRGYRQ-PLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAK 267
Query: 160 V----------GPDAA----------------------------SLRRVVWIFCRTRLIL 181
D A SL +V++ ++
Sbjct: 268 TRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLM 327
Query: 182 SIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWA 241
S I L FSGP + K L+++ T++ + L +T +++ L +
Sbjct: 328 SFFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFH 386
Query: 242 LNYRTGVRLRGAILTMAFKKILKLKNIKEKS--LGELINICSNDGQRMFEAAAVGSLLAG 299
+ + +G+R++ A++ ++K L + N KS +GE++N+ S D QR + A +++
Sbjct: 387 ICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWS 446
Query: 300 GPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMN 359
P+ IL + + LGP+ G AV +L P + T ++ + + D R++ MN
Sbjct: 447 APLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMN 506
Query: 360 EVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFS 419
E+L IK +K+YAW AF V IR+EE ++L+K+ Y ++ + ++ TF+
Sbjct: 507 EILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFA 566
Query: 420 VHMTLGFD--LTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVH 477
V++T+ + L A AF + +FN + F L + P + S+ +ASV++ R + EE+
Sbjct: 567 VYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELE 626
Query: 478 --MIKNKPASP---HIKIEMKNATLAWDSS 502
I+ +P I ++NAT W S
Sbjct: 627 PDSIERRPVKDGGGTNSITVRNATFTWARS 656
Score = 90.1 bits (222), Expect = 1e-17
Identities = 66/215 (30%), Positives = 99/215 (46%), Gaps = 14/215 (6%)
Query: 574 LQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT--------- 624
L L I++ I G+ VGI G G+GK+SL + EG I I G
Sbjct: 1306 LDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHD 1365
Query: 625 ----FAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGE 680
+ Q + + +LR N+ +Y +E + L L+ ++ LP E E
Sbjct: 1366 LRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAE 1425
Query: 681 RGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFV 740
G NLS GQRQ + LARAL I +LD+ +A+D + + S IR + TVL +
Sbjct: 1426 GGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTI 1484
Query: 741 THQLQYLVDCDEVIFMKEGCITERGTHEELMNLNG 775
H+L ++D VI + +G I E G +L+ G
Sbjct: 1485 AHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG 1519
Score = 77.4 bits (189), Expect = 9e-14
Identities = 107/541 (19%), Positives = 223/541 (41%), Gaps = 52/541 (9%)
Query: 913 YYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRIL 972
Y ++ + L+L + FV G +R + + ++R+ L ++ G I+
Sbjct: 366 YTVLLFVTACLQTLVLHQYFHICFVSG-MRIKTAVIGAVYRKALVITNSARKSSTVGEIV 424
Query: 973 NRFSKDMDE-----VDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSV 1027
N S D + + + A + VIL + + + G P L V +V++ V
Sbjct: 425 NLMSVDAQRFMDLATYINMIWSAPL---QVILALYLLWLNLG--PSVLAGVAVMVLMVPV 479
Query: 1028 LHIVSRVL----IRELKRLDNITQSPFLSHITSSIQGLATIHAYN---KGQEFLHRYQEL 1080
+++ + +K DN + ++ I + I+ L ++A+ K + R +EL
Sbjct: 480 NAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNGIKVLK-LYAWELAFKDKVLAIRQEEL 536
Query: 1081 LDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLT 1140
++ + W+ + + T + + + I A ++ L
Sbjct: 537 KVLKKSAYLSAVGTFTWVCTPF----LVALCTFAVYVTIDENNILDAQTAFV---SLALF 589
Query: 1141 GLFQFTVRLA----SETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFE 1196
+ +F + + S S++R+ ++ LE P I+ + P D +T
Sbjct: 590 NILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELE-PDSIERR-PVKDGGGTNSITVR 647
Query: 1197 NAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGV 1256
NA + + P L ++F+I + +VG+ G GKSSL AL ++ G + I G
Sbjct: 648 NATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG- 706
Query: 1257 RISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLP 1316
++ +PQ+ + + ++R N+ Q E ++ + + LP
Sbjct: 707 ------------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILP 754
Query: 1317 LKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETI---R 1373
+E+ E G N S G++Q + +ARA+ + I + D+ +A+D I E + +
Sbjct: 755 SGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPK 814
Query: 1374 EAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDS--SRFYAMFAAAEN 1431
+ T + + H + + D I+V++ G++ E + LL+ D + F +A+ E
Sbjct: 815 GMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQ 874
Query: 1432 K 1432
+
Sbjct: 875 E 875
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 654 bits (1688), Expect = 0.0
Identities = 364/863 (42%), Positives = 525/863 (60%), Gaps = 31/863 (3%)
Query: 577 TLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILN 636
TL + ++ G+L+ + G VG+GK+SL+SA+LG++ G +++ G AYV+QQ W+ +
Sbjct: 427 TLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFS 486
Query: 637 ATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLA 696
TLR NILFGK+Y++ERY V+ +C L+ DL +L DLT IG+RG LSGGQ+ R++LA
Sbjct: 487 GTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLA 546
Query: 697 RALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFM 756
RA+Y D IY+LDDPLSA+DA V H+F I + L K + VTHQLQYL +++ +
Sbjct: 547 RAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILIL 606
Query: 757 KEGCITERGTHEELMNLNGDYATIFN-NLLLGETPPVE----INSKKETSGSQKKSQDKG 811
K+G + ++GT+ E + D+ ++ + E PPV + ++ + S Q
Sbjct: 607 KDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSR 666
Query: 812 PKTGSVKKEKAVKPEEGQLVQL----EEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFM 867
P K+ A++ ++ + V + E + +G V + Y Y +A + F+ ++ L
Sbjct: 667 PSL----KDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNT 722
Query: 868 LNVGSTAFSTWWLSYWI-KQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVML 926
+ WWLSYW KQ N TV G + + + +Y IY+ +
Sbjct: 723 AAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVT------EKLDLNWYLGIYSGLTVATV 776
Query: 927 ILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRL 986
+ R ++ + +S LH+++F IL++P+ FFD P GRILNRFSKD+ +D L
Sbjct: 777 LFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLL 836
Query: 987 PFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNIT 1046
P FIQ ++ V V + V PW + + PL I+F L R++KRL++ T
Sbjct: 837 PLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTT 896
Query: 1047 QSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQ----APFFLFTCAMRWLAVRL 1102
+SP SH++SS+QGL TI AY K +E R QEL D +Q +FLF RW AVRL
Sbjct: 897 RSPVFSHLSSSLQGLWTIRAY-KAEE---RCQELFDAHQDLHSEAWFLFLTTSRWFAVRL 952
Query: 1103 DLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVER 1162
D I + +++ + GLA+SYA+ L G+FQ+ VR ++E E SVER
Sbjct: 953 DAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVER 1012
Query: 1163 INHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEK 1222
+ Y L EAP + K P P WP EG + F+N Y PLVLK ++ IK +EK
Sbjct: 1013 VIEYTD-LEKEAPWEYQ-KRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEK 1070
Query: 1223 IGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSG 1282
+GIVGRTG+GKSSL ALFRL E G I ID + ++IGL DLR K+SIIPQEPVLF+G
Sbjct: 1071 VGIVGRTGAGKSSLISALFRLSEPEGK-IWIDKILTTEIGLHDLRKKMSIIPQEPVLFTG 1129
Query: 1283 TVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIAR 1342
T+R NLDPFN++T++++W+AL+ +KE I LP K+++E+ E+G NFSVG+RQL+C+AR
Sbjct: 1130 TMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLAR 1189
Query: 1343 ALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQ 1402
A+LR +ILI+DEATA +D TD LIQ+ IRE FA CT+LTIAHRL+T++ SD+IMVL
Sbjct: 1190 AILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDS 1249
Query: 1403 GQVVEFDTPSVLLSNDSSRFYAM 1425
G++ E+D P VLL N S FY M
Sbjct: 1250 GRLKEYDEPYVLLQNKESLFYKM 1272
Score = 144 bits (362), Expect = 8e-34
Identities = 108/419 (25%), Positives = 207/419 (49%), Gaps = 22/419 (5%)
Query: 99 HPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELN 158
+P+ +A L S + F WL+ L ++ HK+ L +D++S+ + S L+ W +E+
Sbjct: 11 NPLQDANLCSRVFFWWLNPLFKIGHKR-RLEEDDMYSVLPEDRSQHLGEELQGFWDKEVL 69
Query: 159 EVGPDAAS---LRRVVWIFCRTRLILSIVCLMITQLAGFSGPAFMVKHLLEYTQ------ 209
DA R ++ + ++ L+L I L I + A P F+ K ++ Y +
Sbjct: 70 RAENDAQKPSLTRAIIKCYWKSYLVLGIFTL-IEESAKVIQPIFLGK-IINYFENYDPMD 127
Query: 210 --ATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKLKN 267
A + Y+ +L L+ I+ L + G+RLR A+ M ++K L+L N
Sbjct: 128 SVALNTAYAYATVLTFCTLILAILHH----LYFYHVQCAGMRLRVAMCHMIYRKALRLSN 183
Query: 268 IK--EKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAV 325
+ + + G+++N+ SND + + L GP+ AI + +G + G AV
Sbjct: 184 MAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAV 243
Query: 326 FILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIR 385
I+ P +L + R K TD R++ MNEV+T I+ IKMYAW K+FS + +R
Sbjct: 244 LIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLR 303
Query: 386 EEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTF 445
++E + ++ + + + I VTF+ ++ LG +TA++ F VT++ ++
Sbjct: 304 KKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRL 363
Query: 446 ALKV-TPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNK-PASPHIKIEMKNATLAWDSS 502
+ + P +++ +SEA V++ R ++ L++E+ + P+ + +++ T WD +
Sbjct: 364 TVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKA 422
Score = 89.7 bits (221), Expect = 2e-17
Identities = 113/510 (22%), Positives = 218/510 (42%), Gaps = 29/510 (5%)
Query: 914 YASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILN 973
YA++ ++ IL + +R + ++R+ LR T TG+I+N
Sbjct: 137 YATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVN 196
Query: 974 RFSKDM---DEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHI 1030
S D+ D+V V L F +Q I V + M G+ L + L+IL +
Sbjct: 197 LLSNDVNKFDQVTVFLHFLWAGPLQ-AIAVTALLWMEIGIS--CLAGMAVLIILLPLQSC 253
Query: 1031 VSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFL 1090
++ + T + + + I G+ I Y + F + L +
Sbjct: 254 FGKLFSSLRSKTATFTDAR-IRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILR 312
Query: 1091 FTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISY--AVQLTGLFQFTVR 1148
+C S ++ T VL+ I + +A++ AV+LT F
Sbjct: 313 SSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSA 372
Query: 1149 LASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPL 1208
+ +EA S+ RI + L L+ ++ + PS D + V A P
Sbjct: 373 IERVSEA-IVSIRRIQTF---LLLDEISQRNRQLPS-DGKKMVHVQDFTAFWDKASETP- 426
Query: 1209 VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRS 1268
L+ +SFT++P E + +VG G+GKSSL A+ + S G + + G
Sbjct: 427 TLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG------------- 473
Query: 1269 KLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGD 1328
+++ + Q+P +FSGT+RSN+ +Y +++ ++ +K+ + L + + + G
Sbjct: 474 RIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGT 533
Query: 1329 NFSVGERQLLCIARALLRHCKILILDEATAAMDTETDL-LIQETIREAFADCTMLTIAHR 1387
S G++ + +ARA+ + I +LD+ +A+D E L + I + + + + H+
Sbjct: 534 TLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQ 593
Query: 1388 LHTVLGSDRIMVLAQGQVVEFDTPSVLLSN 1417
L + + +I++L G++V+ T + L +
Sbjct: 594 LQYLKAASQILILKDGKMVQKGTYTEFLKS 623
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 653 bits (1685), Expect = 0.0
Identities = 388/917 (42%), Positives = 535/917 (58%), Gaps = 78/917 (8%)
Query: 575 QRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWI 634
+ T+ ++L+I G+LV + G VGSGK+SLISA+LG+M + G I I GT AYV QQ+WI
Sbjct: 651 EATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWI 710
Query: 635 LNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRIS 694
N T++DNILFG E++E+RY VL +C L PDL +LP DL EIGE+G NLSGGQ+QRIS
Sbjct: 711 QNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRIS 770
Query: 695 LARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKH--LKSKTVLFVTHQLQYLVDCDE 752
LARA Y + IY+LDDPLSA+DAHVG HIFN + + LK KT L VTH + +L DE
Sbjct: 771 LARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDE 830
Query: 753 VIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVE------------------- 793
++ + G I E+G++ L+ G++A L P E
Sbjct: 831 IVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISS 890
Query: 794 ----------INSKKETS------------GSQKKSQDKGPKTGSVKK----EKAVKPEE 827
I ++E S G KS KT +V E+ VK ++
Sbjct: 891 VEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQK 950
Query: 828 GQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQG 887
L++ E G V +S+Y Y+QA G F +I+A F++N + S WLS W
Sbjct: 951 --LIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILA-FVMNSVAFIGSNLWLSAW---- 1003
Query: 888 SGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGV-VFVK------GT 940
SDS N Y AS + + V L +G+ VF+ G
Sbjct: 1004 -------------TSDSKIFNS-TDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGF 1049
Query: 941 LRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILV 1000
+ AS+ LH +L ILR+PM+FFDTTPTGRI+NRF+ D+ VD LP +I + +
Sbjct: 1050 VHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGI 1109
Query: 1001 FFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQG 1060
+ MI P F + V PL I++ + + R+L+RLD++T+SP SH + ++ G
Sbjct: 1110 ISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSG 1169
Query: 1061 LATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLM 1120
L I A+ Q FL + +D NQ F + + RWLA+RL+L+ + + LM+V+
Sbjct: 1170 LPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIY 1229
Query: 1121 HGQIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKN 1180
+ G +S A+ +T + VR+ SE E +VERI Y K + EAP + +
Sbjct: 1230 RDTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVEN-EAPW-VTD 1287
Query: 1181 KAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMAL 1240
K P PDWP +G++ F N ++RYR L LVL+ ++ I EKIG+VGRTG+GKSSL L
Sbjct: 1288 KRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCL 1347
Query: 1241 FRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIW 1300
FR++E +GG I IDGV I+ IGL DLR KL+IIPQ+P+LFSG++R NLDPFN Y++++IW
Sbjct: 1348 FRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIW 1407
Query: 1301 DALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAM 1360
ALE H+K +A L L L EV E G N S+G+RQLLC+ RALLR KIL+LDEATAA+
Sbjct: 1408 KALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAV 1467
Query: 1361 DTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSS 1420
D ETD LIQ TI+ FA CT++TIAHRLHT++ SD++MVL G+++E +P LL
Sbjct: 1468 DLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGP 1527
Query: 1421 -RFYAMFAAAENKVAVK 1436
F A A EN + K
Sbjct: 1528 FYFMAKEAGIENVNSTK 1544
Score = 137 bits (346), Expect = 6e-32
Identities = 106/424 (25%), Positives = 194/424 (45%), Gaps = 56/424 (13%)
Query: 99 HPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELN 158
+P A S +T+SW S+ +K+ L++EDVW + + + + E + EL
Sbjct: 193 NPSSIASFLSSITYSWYDSIILKGYKR-PLTLEDVWEVDEEMKTKTLVSKFETHMKRELQ 251
Query: 159 EV-----------------------------GPDAASLRRV---------------VW-- 172
+ DA L V W
Sbjct: 252 KARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLM 311
Query: 173 --IFCRTRLIL--SIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLT 228
+F ++L S + ++ + F P ++K L+ + ++ L L + L
Sbjct: 312 KALFKTFYMVLLKSFLLKLVNDIFTFVSPQ-LLKLLISFASDRDTYLWIGYLCAILLFTA 370
Query: 229 EIVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKLKNI--KEKSLGELINICSNDGQR 286
+++S+ L + L ++ GV++R AI+ +KK L L N+ KE ++GE +N+ S D Q+
Sbjct: 371 ALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQK 430
Query: 287 MFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRK 346
+ + +L + +L + + LGP+ G V +L P S + + K
Sbjct: 431 LMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVK 490
Query: 347 CVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVA 406
+ D+R++ MNE+L+ IK +K +AW +F VQ +R++E + L Q + + V
Sbjct: 491 NMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVF 550
Query: 407 PIVVVIASVVTFSVHMTLGFD--LTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAV 464
+ V+ SVVTFSV++ + + L A +AFT +T+FN + F L + P + S+ +ASV+
Sbjct: 551 QLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVST 610
Query: 465 DRFK 468
+R +
Sbjct: 611 ERLE 614
Score = 90.9 bits (224), Expect = 8e-18
Identities = 66/244 (27%), Positives = 109/244 (44%), Gaps = 20/244 (8%)
Query: 553 SDERPSPEEEEGKHIHLGHLR------LQRTLHSIDLEIQEGKLVGICGSVGSGKTSLIS 606
+D+RP P+ I + + L L I +I + +G+ G G+GK+SL +
Sbjct: 1286 TDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTN 1345
Query: 607 AILGQMTLLEGSIAISGT-------------FAYVAQQAWILNATLRDNILFGKEYDEER 653
+ + G I I G + Q + + +LR N+ Y +E
Sbjct: 1346 CLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEE 1405
Query: 654 YNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLS 713
L L+ +A L E+ E G NLS GQRQ + L RAL I +LD+ +
Sbjct: 1406 IWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATA 1465
Query: 714 ALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNL 773
A+D N + + I+ TV+ + H+L ++D D+V+ + G I E G+ EEL+ +
Sbjct: 1466 AVDLETDN-LIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQI 1524
Query: 774 NGDY 777
G +
Sbjct: 1525 PGPF 1528
Score = 80.5 bits (197), Expect = 1e-14
Identities = 95/434 (21%), Positives = 187/434 (43%), Gaps = 40/434 (9%)
Query: 994 IQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSR----VLIRELKRLDNITQSP 1049
+Q V+ +FF + P L VG +V++ + I+S + ++ +K D
Sbjct: 446 LQIVLSIFFLWRELG---PSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKR---- 498
Query: 1050 FLSHITSSIQGLATIHAYNKGQEFLHRYQELLDD---NQAPFFLFTCAMRWLAVRLDLIS 1106
L + + G+ + + F + Q L N F C + ++ +L +
Sbjct: 499 -LKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFV-FQLTPVL 556
Query: 1107 IALITTTGLMIVLMHGQIPPAYAGLAIS-YAVQLTGLFQFTVRLASETEARFTSVERINH 1165
++++T + ++V + + A +I+ + + L + ++S +A S ER+
Sbjct: 557 VSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQAS-VSTERLEK 615
Query: 1166 YIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGI 1225
Y+ L+ A I++ D + + F A + + ++ V+ I + + +
Sbjct: 616 YLGGDDLDTSA-IRH-----DCNFDKAMQFSEASFTWEHDSEATVRDVNLDIMAGQLVAV 669
Query: 1226 VGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVR 1285
+G GSGKSSL A+ +E G I I G + +PQ+ + +GT++
Sbjct: 670 IGPVGSGKSSLISAMLGEMENVHGHITIKGTT-------------AYVPQQSWIQNGTIK 716
Query: 1286 SNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALL 1345
N+ ++ E + LE + + LP +E+ E G N S G++Q + +ARA
Sbjct: 717 DNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATY 776
Query: 1346 RHCKILILDEATAAMDTETDLLIQETI---REAFADCTMLTIAHRLHTVLGSDRIMVLAQ 1402
++ I +LD+ +A+D I + T L + H +H + D I+VL
Sbjct: 777 QNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGN 836
Query: 1403 GQVVEFDTPSVLLS 1416
G +VE + S LL+
Sbjct: 837 GTIVEKGSYSALLA 850
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 647 bits (1670), Expect = 0.0
Identities = 437/1398 (31%), Positives = 709/1398 (50%), Gaps = 114/1398 (8%)
Query: 106 LFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNE--VGPD 163
L S T+ W+++ + AHKK + + + L + N +RL + ++ + G
Sbjct: 224 LLSKGTYWWMNAFIKTAHKK-PIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQ 282
Query: 164 AASLRRVVW-----IFCRTRLILSIVCLMITQLAGFSGPAFM---VKHLLE--------- 206
A R +W F R RL+LS ++ L GF+GP + V HL +
Sbjct: 283 GA---RAIWQALSHAFGR-RLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKT 338
Query: 207 -----YTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMAFKK 261
Y +++ L + +L + L L +++ L ++ + TG+ LRGAI T + K
Sbjct: 339 QFLGVYFVSSQEFLANAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNK 398
Query: 262 ILKLK----NIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGP 317
I+ L ++ E + G++ N+ + D ++ + L PV I+G+I ILG
Sbjct: 399 IMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGV 458
Query: 318 TGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAF 377
+ +G+AV IL P F + + +R + ++ER+++ NE+L IK +K+YAW F
Sbjct: 459 SALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIF 518
Query: 378 SQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTL--GFDLTAAQAFT 435
V+ R +E L + SI++ + + + A ++TF H++ D + + AF
Sbjct: 519 RTRVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFA 578
Query: 436 VVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNA 495
+++F+ + L + V+S +A V+V + E I+ + +PH A
Sbjct: 579 SLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAE---IREEQCAPHEPTPQGPA 635
Query: 496 TLAWDSSHSSIQNSPKLTPKMKKDKRAS-RGKKEKVRQLQRTEH----QAVLAEQKGHLL 550
S Q P K+ R RG ++ L + + G+
Sbjct: 636 --------SKYQAVPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFT 687
Query: 551 LDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILG 610
D P TL +I + I G+L I G VG GK+SL+ A LG
Sbjct: 688 WTPDGIP-------------------TLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALG 728
Query: 611 QMTLLEGSIAIS--------------------------GTFAYVAQQAWILNATLRDNIL 644
+M + G++ S G AY +Q+ W+LNAT+ +NI+
Sbjct: 729 EMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENII 788
Query: 645 FGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRS 704
F ++++RY V+ +C L+PD+ ILP D T+IGERG NLSGGQRQRIS+ARALY +
Sbjct: 789 FESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHAN 848
Query: 705 IYILDDPLSALDAHVGNHIFNSAIRKHLKS--KTVLFVTHQLQYLVDCDEVIFMKEGCIT 762
+ LDDP SALD H+ +H+ + I + L+ +TV+ VTH+LQYL D +I MK+G I
Sbjct: 849 VVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQ 908
Query: 763 ERGTHEELMNLNGDYATIFNNLLLGETPPVE---INSKKETSGSQKKSQDKGPKTGSVK- 818
GT ++ + L+ + +E + +K T Q S+ + G ++
Sbjct: 909 REGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQGLSRAMSSRDGLLQD 968
Query: 819 ----KEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTA 874
+E+A + EE + + +PW Y+ +AG L L++ + + ++ A
Sbjct: 969 EEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQLLKHMVLVA 1028
Query: 875 FSTWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGV 934
+WL+ W T R S ++ YA ++ + ++ ++L + V
Sbjct: 1029 ID-YWLAKWTDSALTLTPAARNCSLSQECTLDQT----VYAMVFTVLCSLGIVLCLVTSV 1083
Query: 935 VFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFI 994
L+ + RLH L RI+ +PM+FF+TTP G ILNRFS D + +D +P E
Sbjct: 1084 TVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLS 1143
Query: 995 QNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHI 1054
++ +L + +I+ V P FLVA+ PL I+ + RV R+L++LD+ TQ P LSH
Sbjct: 1144 RSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHF 1203
Query: 1055 TSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLIS--IALITT 1112
+++GL TI A+ F + E D N T A RWL VR++ I + LI
Sbjct: 1204 AETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAA 1263
Query: 1113 TGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSL 1172
+ +H ++ GL ++YA+ ++ + VR ++ E + +V+RI+ +KT +
Sbjct: 1264 VTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAE 1323
Query: 1173 EAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSG 1232
+ +WP +G++ +N +RY +L VLK V+ I P +KIGI GRTGSG
Sbjct: 1324 SYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSG 1383
Query: 1233 KSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFN 1292
KSS +A FR+V+ G I IDG+ I+ + L LRS+LSII Q+PVLFSGT+R NLDP
Sbjct: 1384 KSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPER 1443
Query: 1293 QYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILI 1352
+ ++ +W+ALE +K + LP L++ + E G+NFS G+RQL C+ARA +R I I
Sbjct: 1444 KCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFI 1503
Query: 1353 LDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPS 1412
+DEATA++D T+ ++Q+ + AFAD T++TIAHR+HT+L +D ++VL +G ++EFD P
Sbjct: 1504 MDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPE 1563
Query: 1413 VLLSNDSSRFYAMFAAAE 1430
LLS S F A F A+
Sbjct: 1564 KLLSRKDSVF-ASFVRAD 1580
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 616 bits (1588), Expect = e-176
Identities = 353/926 (38%), Positives = 523/926 (56%), Gaps = 82/926 (8%)
Query: 553 SDERPSPEEEEGKHIHLGHL------------RLQRTLHSIDLEIQEGKLVGICGSVGSG 600
S E P+ E K I G+ L TLHS+D+++ +G LV + G VG G
Sbjct: 607 SQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCG 666
Query: 601 KTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNS 660
K+SL+SA+LG+M LEG + + G+ AYV QQAWI N TL++N+LFGK + +RY L +
Sbjct: 667 KSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEA 726
Query: 661 CCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVG 720
C L DL +LP D TEIGE+G NLSGGQRQR+SLARA+YSD I++LDDPLSA+D+HV
Sbjct: 727 CALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVA 786
Query: 721 NHIFNSAIRKH--LKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYA 778
HIF+ I L KT + VTH + +L D +I + +G ++E G + L+ NG +A
Sbjct: 787 KHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFA 846
Query: 779 -----------------------------------TIFNNLLLGETPPVEINSKKETSGS 803
T+ N+ L + PV +K+
Sbjct: 847 NFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQ 906
Query: 804 QKKSQDKGPKTGSVKKEKAVKPEE----------GQLVQLEEKGQGSVPWSVYGVYIQAA 853
G G + + P E G L Q E+ G+V SV+ Y +A
Sbjct: 907 LSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAV 966
Query: 854 GGPLAFLVIMALFMLNVGSTAFSTW---WLSYWIKQGSGNTTVTRGNETSVSDSMKDNPH 910
G +A+ +L VG +A + WLS W +++DS ++N
Sbjct: 967 G----LCTTLAICLLYVGQSAAAIGANVWLSAWTND-------------AMADSRQNNTS 1009
Query: 911 MQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGR 970
++ +YA + L + + G ++A+ LH L +RSP FFDTTP+GR
Sbjct: 1010 LRL--GVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGR 1067
Query: 971 ILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHI 1030
ILN FSKD+ VD L M + + + +I P F V + PL +L++++
Sbjct: 1068 ILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQR 1127
Query: 1031 VSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFL 1090
R+LKRL+++++SP SH + ++ G + I AYN+ ++F +D NQ +
Sbjct: 1128 FYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYP 1187
Query: 1091 FTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLA 1150
+ + RWL++ ++ + ++ L V+ + P GL++SY++Q+T + +R+
Sbjct: 1188 YIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMM 1247
Query: 1151 SETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVL 1210
S+ E+ +VER+ Y KT EAP ++ P WP GEV F N +RYR L LVL
Sbjct: 1248 SDLESNIVAVERVKEYSKT-ETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVL 1306
Query: 1211 KKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKL 1270
+ +S + EK+GIVGRTG+GKSS+ + LFR++E + G I+IDG+ ++DIGL DLRS+L
Sbjct: 1307 RDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQL 1366
Query: 1271 SIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNF 1330
+IIPQ+P+LFSGT+R NLDPF Y+E+ IW ALE +H+ ++ P L+ + E G+N
Sbjct: 1367 TIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENL 1426
Query: 1331 SVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHT 1390
SVG+RQL+C+ARALLR +IL+LDEATAA+D ETD LIQ TIR F CT+LTIAHRL+T
Sbjct: 1427 SVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNT 1486
Query: 1391 VLGSDRIMVLAQGQVVEFDTPSVLLS 1416
++ R++VL +G V EFD+P+ L++
Sbjct: 1487 IMDYTRVLVLDKGVVAEFDSPANLIA 1512
Score = 132 bits (333), Expect = 2e-30
Identities = 102/440 (23%), Positives = 202/440 (45%), Gaps = 35/440 (7%)
Query: 92 RTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLER 151
+ + +P +AG S + F W + +A ++ L +D+WSL + + S + ++L
Sbjct: 200 KNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRH-PLEEKDLWSLKEEDRSQMVVQQLLE 258
Query: 152 LWQEELNEVG-------------------------PDAASLRRVVWIFCRTRLILSIVCL 186
W+++ + P S + + + ++S
Sbjct: 259 AWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFK 318
Query: 187 MITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRT 246
+I L F P ++ L+ + + + L+ + L +++S L + + T
Sbjct: 319 LIQDLLSFINPQ-LLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVT 377
Query: 247 GVRLRGAILTMAFKKILKLKNIKEKS--LGELINICSNDGQRMFEAAAVGSLLAGGPVVA 304
GV+ R I+ + ++K L + N +++ +GE++N+ S D QR + A +LL P+
Sbjct: 378 GVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQI 437
Query: 305 ILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTY 364
IL + + LGP+ G A +L P + F+ K + D R++ M+E+L
Sbjct: 438 ILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNG 497
Query: 365 IKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGV---APIVVVIASVVTFSVH 421
IK +K+YAW +F + V+ IR+ E ++L A Y + T +P +V + ++ + V+
Sbjct: 498 IKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVY-VY 556
Query: 422 MTLGFDLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEV--HMI 479
+ L A +AF V++FN + L + P + +L++ASV++ R + EE+ +
Sbjct: 557 VDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSV 616
Query: 480 KNKPASPHIKIEMKNATLAW 499
+ K SP I + + T W
Sbjct: 617 ERKTISPGYAITIHSGTFTW 636
Score = 85.9 bits (211), Expect = 3e-16
Identities = 114/529 (21%), Positives = 219/529 (41%), Gaps = 39/529 (7%)
Query: 917 IYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFS 976
++ SM LIL+ +FV G ++ + + ++R+ L + G I+N S
Sbjct: 356 MFLCSMMQSLILQHYYHYIFVTG-VKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMS 414
Query: 977 KDMDEVDVRLPFQAEMF---IQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSR 1033
D PF ++ +Q ++ ++F + + P L V +V+L + V+
Sbjct: 415 VDAQRFMDLAPFLNLLWSAPLQIILAIYF---LWQNLGPSVLAGVAFMVLLIPLNGAVA- 470
Query: 1034 VLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQ-----ELLDDNQAPF 1088
V +R + + + ++ + G+ + Y FL + + EL A +
Sbjct: 471 VKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAY 530
Query: 1089 FLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVR 1148
T W+ + LIT + V + + A +++S L +
Sbjct: 531 LHTTTTFTWMC---SPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQ 587
Query: 1149 LASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPL 1208
L S S++RI ++ L+ P ++ K SP + +T + + ++LP
Sbjct: 588 LISNLTQASVSLKRIQQFLSQEELD-PQSVERKTISPGYA----ITIHSGTFTWAQDLPP 642
Query: 1209 VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRS 1268
L + + + +VG G GKSSL AL +E G + + G
Sbjct: 643 TLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG------------- 689
Query: 1269 KLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGD 1328
++ +PQ+ + + T++ N+ + LE + + LP ++E+ E G
Sbjct: 690 SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGI 749
Query: 1329 NFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETI---REAFADCTMLTIA 1385
N S G+RQ + +ARA+ I +LD+ +A+D+ I + + A T + +
Sbjct: 750 NLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVT 809
Query: 1386 HRLHTVLGSDRIMVLAQGQVVEFDT-PSVLLSNDS-SRFYAMFAAAENK 1432
H + + +D I+VLA GQV E P++L N S + F +A E++
Sbjct: 810 HGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQ 858
Score = 82.0 bits (201), Expect = 4e-15
Identities = 70/275 (25%), Positives = 119/275 (43%), Gaps = 18/275 (6%)
Query: 515 KMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLR- 573
+M D ++ E+V++ +TE +A + + P E E ++ + +
Sbjct: 1245 RMMSDLESNIVAVERVKEYSKTETEAPWVVEGSR---PPEGWPPRGEVEFRNYSVRYRPG 1301
Query: 574 LQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT--------- 624
L L + L + G+ VGI G G+GK+S+ + + +G I I G
Sbjct: 1302 LDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHD 1361
Query: 625 ----FAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGE 680
+ Q + + TLR N+ Y EE L L ++ P+ + E
Sbjct: 1362 LRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSE 1421
Query: 681 RGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFV 740
G NLS GQRQ + LARAL I +LD+ +A+D N + + IR + TVL +
Sbjct: 1422 GGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDN-LIQATIRTQFDTCTVLTI 1480
Query: 741 THQLQYLVDCDEVIFMKEGCITERGTHEELMNLNG 775
H+L ++D V+ + +G + E + L+ G
Sbjct: 1481 AHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARG 1515
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 591 bits (1524), Expect = e-168
Identities = 340/883 (38%), Positives = 504/883 (57%), Gaps = 50/883 (5%)
Query: 583 LEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT---FAYVAQQAWILNATL 639
LE+++G LVGI G VG GK+SL++AI G++ L G +A+ G F Q+ WI AT+
Sbjct: 593 LEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQFATI 652
Query: 640 RDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARAL 699
RDNILFGK +D + Y VL +C L DL+ILP+ D TE+GE+G LSGGQR RI+LARA+
Sbjct: 653 RDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAV 712
Query: 700 YSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEG 759
Y ++ +Y+LDDPL+A+DA V NH+ + I L T L TH+ +YL D V+ M+ G
Sbjct: 713 YQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADAVLLMEAG 772
Query: 760 CITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKKETSGSQKKSQDKGPKTGSVKK 819
+ G E++ L+ P + +E+ + +S KT +
Sbjct: 773 RLIRAGPPSEILP------------LVQAVPKAWAENGQESDSATAQSVQNPEKTKEGLE 820
Query: 820 EKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWW 879
E+ + G+L+Q E K +G+V VY Y +A G LA ++ +L ++ A + WW
Sbjct: 821 EE--QSTSGRLLQEESKKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQATRNA-ADWW 877
Query: 880 LSYWIKQGSGNTTVTRGNETSVSDSM---------------------------KDNPHMQ 912
LS+WI Q + ++ SM + ++
Sbjct: 878 LSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIR 937
Query: 913 YYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRIL 972
+Y ++YA V + +R V+F GTL+A++ LH L R+L +P+ FF+ TPTGRIL
Sbjct: 938 FYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRIL 997
Query: 973 NRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVS 1032
NRFS D+ D LPF + + N + + ++ PW L+ + PL I++ +
Sbjct: 998 NRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHY 1057
Query: 1033 RVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFT 1092
R REL+RL ++T SP SH+ ++ GL+ + A F LL+ NQ F +
Sbjct: 1058 RASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATS 1117
Query: 1093 CAMRWLAVRLDLISIALITTTGLMIVLMH--GQIPPAYAGLAISYAVQLTGLFQFTVRLA 1150
M+WL +RL L+ A+++ + ++ H G P GL++SYA+ LTGL V
Sbjct: 1118 ATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSF 1177
Query: 1151 SETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVL 1210
++TEA SVER+ Y T L + + W +G V F++ + YR LP L
Sbjct: 1178 TQTEAMLVSVERLEEY--TCDLPQEPQGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNAL 1235
Query: 1211 KKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKL 1270
V+F ++P EK+GIVGRTGSGKSSL + LFRL+E S G + +DGV S + LA LRS+L
Sbjct: 1236 DGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQL 1295
Query: 1271 SIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNF 1330
+IIPQEP LFSGTVR NLDP + + +W AL++ H+ E I + L+ E+ E G +
Sbjct: 1296 AIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSMG-GLDGELGEGGRSL 1354
Query: 1331 SVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHT 1390
S+G+RQLLC+ARALL KIL +DEATA++D +TD L+Q+TI + FA+ T+LTIAHRL+T
Sbjct: 1355 SLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNT 1414
Query: 1391 VLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENKV 1433
+L SDR++VL G+VVE D+P+ L + S F + +++ V
Sbjct: 1415 ILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSSQQGV 1457
Score = 100 bits (250), Expect = 8e-21
Identities = 109/431 (25%), Positives = 188/431 (43%), Gaps = 41/431 (9%)
Query: 102 DNAGLFSCMTFSWLSSL-ARVAHKKGELSM-EDVWSLSKHESSDVNCRRLERLWQEELNE 159
D S +++WL+ L AR A GEL +D+ L R + WQE
Sbjct: 173 DGESWLSRFSYAWLAPLLARGAC--GELRQPQDICRLPHRLQPTYLARVFQAHWQE---- 226
Query: 160 VGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSL 219
A R + F R L L ++ L+ T L GFSGP ++ L+ + + + L + L
Sbjct: 227 ---GARLWRALYGAFGRCYLALGLLKLVGTML-GFSGP-LLLSLLVGFLEEGQEPLSHGL 281
Query: 220 LLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKLKNIKEKSLGELINI 279
L LGL ++ + Y+ ++ RGA+L + + K L+L + + GE +N+
Sbjct: 282 LYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPSRPPT-GEALNL 340
Query: 280 CSNDGQRMFEAAAVGSLLAGGPV--VAILGMIYNVIILGPTGFLGSAVFILFYPA-MMFA 336
D +R+ A G P+ L ++Y + + G G + +L P + A
Sbjct: 341 LGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVG--GLILALLLVPVNKVIA 398
Query: 337 SRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAG 396
+R+ A ++ + D RV+ + E+L+ I+ IK W +A V+ R E L
Sbjct: 399 TRIMAS-NQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIK 457
Query: 397 YFQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFALKVTPFSVKS 456
Y + V + + V+ S+V F ++ +G LTA + FT + + + L P+ +
Sbjct: 458 YLDAACVYLWAALPVVISIVIFITYVLMGHQLTATKVFTALALVRMLILPLNNFPWVING 517
Query: 457 LSEASVAVDRFKSLFLMEEVH--------------------MIKNKPASPHIKIEMKNAT 496
L EA V++DR + LFL H + + PA P +E+ A
Sbjct: 518 LLEAKVSLDRIQ-LFLDLPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPSTVLELHGAL 576
Query: 497 LAWDSSHSSIQ 507
+WD +S++
Sbjct: 577 FSWDPVGTSLE 587
Score = 85.1 bits (209), Expect = 4e-16
Identities = 57/212 (26%), Positives = 101/212 (47%), Gaps = 15/212 (7%)
Query: 574 LQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT--------- 624
L L + +Q G+ +GI G GSGK+SL+ + + G + + G
Sbjct: 1231 LPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQ 1290
Query: 625 ----FAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGE 680
A + Q+ ++ + T+R+N+ + + L C L + + D E+GE
Sbjct: 1291 LRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSMGGLD-GELGE 1349
Query: 681 RGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFV 740
G +LS GQRQ + LARAL +D I +D+ +++D + + I K +KTVL +
Sbjct: 1350 GGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKT-DQLLQQTICKRFANKTVLTI 1408
Query: 741 THQLQYLVDCDEVIFMKEGCITERGTHEELMN 772
H+L +++ D V+ ++ G + E + L N
Sbjct: 1409 AHRLNTILNSDRVLVLQAGRVVELDSPATLRN 1440
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 558 bits (1437), Expect = e-158
Identities = 318/872 (36%), Positives = 493/872 (56%), Gaps = 43/872 (4%)
Query: 577 TLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISG------------- 623
TL +ID+ I G+L I G VG GK+SL+ AILG+M LEG + S
Sbjct: 651 TLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRS 710
Query: 624 ----TFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIG 679
+ AY AQ+ W+LNAT+ +NI FG ++++RY +V ++C L+PD+ +LP D TEIG
Sbjct: 711 RNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIG 770
Query: 680 ERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKS--KTV 737
ERG NLSGGQRQRI +ARALY + +I LDDP SALD H+ +H+ I K L+ +T+
Sbjct: 771 ERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTL 830
Query: 738 LFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSK 797
+ VTH+LQYL D +I MK+G + GT +++ + + + L+ + +E + +
Sbjct: 831 VLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDME 890
Query: 798 KETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSV-------PWSVYGVYI 850
+ + ++K+ + + K + + EE + + E+ +V PW Y+
Sbjct: 891 ADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYL 950
Query: 851 QAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPH 910
+ G L L+I + + + A +WL+ W + S N T + ++T
Sbjct: 951 TSGGFFLLILMIFSKLLKHSVIVAID-YWLATWTSEYSINNT-GKADQT----------- 997
Query: 911 MQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGR 970
YY + +++ + L + + L A+ LH L +I+ P++FFDTTP G
Sbjct: 998 --YYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGL 1055
Query: 971 ILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHI 1030
ILNRFS D + +D +P E ++ +L +GMI+ P FLVA+ PL + F +
Sbjct: 1056 ILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQK 1115
Query: 1031 VSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFL 1090
RV ++L+ LD+ TQ P L H + + +GL TI A+ F R EL D N +
Sbjct: 1116 YFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLF 1175
Query: 1091 FTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLA 1150
+ A RWL VR D + ++ T I + G GL + YA+ +T + VR
Sbjct: 1176 LSAANRWLEVRTDYLGACIVLTAS--IASISGSSNSGLVGLGLLYALTITNYLNWVVRNL 1233
Query: 1151 SETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVL 1210
++ E + +V+++N ++ S + WPQEGE+ + +RY NL VL
Sbjct: 1234 ADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVL 1293
Query: 1211 KKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKL 1270
K V IKP +K+GI GRTGSGKSSL +A FR+V++ G I IDG+ IS + L LRS+L
Sbjct: 1294 KHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRL 1353
Query: 1271 SIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNF 1330
SII Q+P+LFSG++R NLDP + T+D++W+ALE +K + LP L++ V E G+NF
Sbjct: 1354 SIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENF 1413
Query: 1331 SVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHT 1390
SVG+RQL C+ARA +R ILI+DEATA++D T+ ++Q+ + AFAD T++TIAHR+ +
Sbjct: 1414 SVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSS 1473
Query: 1391 VLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRF 1422
++ + ++V ++G +VE DT LL++ + F
Sbjct: 1474 IMDAGLVLVFSEGILVECDTVPNLLAHKNGLF 1505
Score = 124 bits (311), Expect = 7e-28
Identities = 100/396 (25%), Positives = 195/396 (49%), Gaps = 28/396 (7%)
Query: 106 LFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNEVGPDAA 165
L S T+ W+++L AHKK + ++ + L + N L+ ++E+ +V D
Sbjct: 222 LLSKATYWWMNTLIISAHKK-PIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVA-DHP 279
Query: 166 SLRRVVWI-----FCRTRLILSIVCLMITQLAGFSGP---AFMVKHLLEYTQATESN--- 214
+ +W+ F R ++LS + L GF+GP + +V+ + E T +
Sbjct: 280 NRTPSIWLAMYRAFGRP-ILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGI 338
Query: 215 ---------LQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKL 265
L+ + +L + L L I++ L ++ + TG+ LRGA+L M + KIL+L
Sbjct: 339 SETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRL 398
Query: 266 K----NIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFL 321
++ E +LG++ N+ + + ++ + L PV I+G+I +LG + +
Sbjct: 399 STSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALV 458
Query: 322 GSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSV 381
G+AV +L P F + A ++ + + ER++K NE+L IK +K+YAW F +SV
Sbjct: 459 GAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSV 518
Query: 382 QKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVH-MTLGFDLTAAQAFTVVTVF 440
++ R +E L+ + S+++ + + + A + TF H G +L A+AF +++F
Sbjct: 519 EETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLF 578
Query: 441 NSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEV 476
+ + L + V+ +A ++V + L +E+
Sbjct: 579 HILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEI 614
Score = 81.3 bits (199), Expect = 6e-15
Identities = 60/221 (27%), Positives = 101/221 (45%), Gaps = 15/221 (6%)
Query: 574 LQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISG---------- 623
L+ L + I+ G+ VGICG GSGK+SL A + + +G I I G
Sbjct: 1289 LKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHT 1348
Query: 624 ---TFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGE 680
+ + Q + + ++R N+ + ++R L L+ + LP + E
Sbjct: 1349 LRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTE 1408
Query: 681 RGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFV 740
G N S GQRQ LARA SI I+D+ +++D N I + +TV+ +
Sbjct: 1409 GGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATEN-ILQKVVMTAFADRTVVTI 1467
Query: 741 THQLQYLVDCDEVIFMKEGCITERGTHEELM-NLNGDYATI 780
H++ ++D V+ EG + E T L+ + NG ++T+
Sbjct: 1468 AHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTL 1508
>gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5
[Homo sapiens]
Length = 1466
Score = 550 bits (1416), Expect = e-156
Identities = 317/790 (40%), Positives = 462/790 (58%), Gaps = 51/790 (6%)
Query: 577 TLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILN 636
TL+ I I EG LV + G VG GK+SL+SA+L +M +EG +AI G+ AYV QQAWI N
Sbjct: 660 TLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQN 719
Query: 637 ATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLA 696
+LR+NILFG + +E Y SV+ +C L PDL ILPS D TEIGE+G NLSGGQ+QR+SLA
Sbjct: 720 DSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLA 779
Query: 697 RALYSDRSIYILDDPLSALDAHVGNHIFNSAI--RKHLKSKTVLFVTHQLQYLVDCDEVI 754
RA+YS+ IY+ DDPLSA+DAHVG HIF + I + LK+KT + VTH + YL D +I
Sbjct: 780 RAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVII 839
Query: 755 FMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPP-VEINSKKETSGSQKKSQ----- 808
M G I+E G+++EL+ +G +A E E N SG K+++
Sbjct: 840 VMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENG 899
Query: 809 ----DKGPK----------------------TGSVKKEKAVKPEEGQLVQLEEKGQGSVP 842
D K T ++K +A K E +L++ ++ G V
Sbjct: 900 MLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVK 959
Query: 843 WSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVS 902
SVY Y++A G ++FL I LFM N S S +WLS W N T T V
Sbjct: 960 LSVYWDYMKAIGLFISFLSIF-LFMCNHVSALASNYWLSLWTDDPIVNGTQ---EHTKVR 1015
Query: 903 DSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKF 962
S+ + +++ SMAV + G + AS LH +L ILRSPM F
Sbjct: 1016 LSVYGALGISQGIAVFGYSMAVSI------------GGILASRCLHVDLLHSILRSPMSF 1063
Query: 963 FDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLV 1022
F+ TP+G ++NRFSK++D VD +P +MF+ ++ V +I P + + PL
Sbjct: 1064 FERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLG 1123
Query: 1023 ILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLD 1082
+++ + R+LKRL+++++SP SH ++ G++ I A+ + + F+H+ +D
Sbjct: 1124 LIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVD 1183
Query: 1083 DNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGL 1142
+NQ ++ A RWLAVRL+ + ++ L V+ + GL++SY++Q+T
Sbjct: 1184 ENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTY 1243
Query: 1143 FQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRY 1202
+ VR++SE E +VER+ Y +T EAP +I+ AP WPQ G V F N +RY
Sbjct: 1244 LNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQIQETAPPSSWPQVGRVEFRNYCLRY 1302
Query: 1203 RENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIG 1262
RE+L VL+ ++ TI EK+GIVGRTG+GKSSL + LFR+ E + G I IDG+ I+ IG
Sbjct: 1303 REDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIG 1362
Query: 1263 LADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESE 1322
L DLR K++IIPQ+PVLFSG++R NLDPF+QY+++++W +LE H+K+ ++ LP KL+ E
Sbjct: 1363 LHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHE 1422
Query: 1323 VMENGDNFSV 1332
E G+N V
Sbjct: 1423 CAEGGENLRV 1432
Score = 146 bits (369), Expect = 1e-34
Identities = 113/450 (25%), Positives = 210/450 (46%), Gaps = 49/450 (10%)
Query: 100 PVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNE 159
P +A S +TF W++ L +++ L D+WSL+K ++S+ L + W++E +
Sbjct: 209 PESSASFLSRITFWWITGLIVRGYRQ-PLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAK 267
Query: 160 V----------GPDAA----------------------------SLRRVVWIFCRTRLIL 181
D A SL +V++ ++
Sbjct: 268 TRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLM 327
Query: 182 SIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWA 241
S I L FSGP + K L+++ T++ + L +T +++ L +
Sbjct: 328 SFFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFH 386
Query: 242 LNYRTGVRLRGAILTMAFKKILKLKNIKEKS--LGELINICSNDGQRMFEAAAVGSLLAG 299
+ + +G+R++ A++ ++K L + N KS +GE++N+ S D QR + A +++
Sbjct: 387 ICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWS 446
Query: 300 GPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMN 359
P+ IL + + LGP+ G AV +L P + T ++ + + D R++ MN
Sbjct: 447 APLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMN 506
Query: 360 EVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFS 419
E+L IK +K+YAW AF V IR+EE ++L+K+ Y ++ + ++ TF+
Sbjct: 507 EILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFA 566
Query: 420 VHMTLGFD--LTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVH 477
V++T+ + L A AF + +FN + F L + P + S+ +ASV++ R + EE+
Sbjct: 567 VYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELE 626
Query: 478 --MIKNKPASP---HIKIEMKNATLAWDSS 502
I+ +P I ++NAT W S
Sbjct: 627 PDSIERRPVKDGGGTNSITVRNATFTWARS 656
Score = 77.4 bits (189), Expect = 9e-14
Identities = 107/541 (19%), Positives = 223/541 (41%), Gaps = 52/541 (9%)
Query: 913 YYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRIL 972
Y ++ + L+L + FV G +R + + ++R+ L ++ G I+
Sbjct: 366 YTVLLFVTACLQTLVLHQYFHICFVSG-MRIKTAVIGAVYRKALVITNSARKSSTVGEIV 424
Query: 973 NRFSKDMDE-----VDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSV 1027
N S D + + + A + VIL + + + G P L V +V++ V
Sbjct: 425 NLMSVDAQRFMDLATYINMIWSAPL---QVILALYLLWLNLG--PSVLAGVAVMVLMVPV 479
Query: 1028 LHIVSRVL----IRELKRLDNITQSPFLSHITSSIQGLATIHAYN---KGQEFLHRYQEL 1080
+++ + +K DN + ++ I + I+ L ++A+ K + R +EL
Sbjct: 480 NAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNGIKVLK-LYAWELAFKDKVLAIRQEEL 536
Query: 1081 LDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLT 1140
++ + W+ + + T + + + I A ++ L
Sbjct: 537 KVLKKSAYLSAVGTFTWVCTPF----LVALCTFAVYVTIDENNILDAQTAFV---SLALF 589
Query: 1141 GLFQFTVRLA----SETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFE 1196
+ +F + + S S++R+ ++ LE P I+ + P D +T
Sbjct: 590 NILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELE-PDSIERR-PVKDGGGTNSITVR 647
Query: 1197 NAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGV 1256
NA + + P L ++F+I + +VG+ G GKSSL AL ++ G + I G
Sbjct: 648 NATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG- 706
Query: 1257 RISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLP 1316
++ +PQ+ + + ++R N+ Q E ++ + + LP
Sbjct: 707 ------------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILP 754
Query: 1317 LKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETI---R 1373
+E+ E G N S G++Q + +ARA+ + I + D+ +A+D I E + +
Sbjct: 755 SGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPK 814
Query: 1374 EAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDS--SRFYAMFAAAEN 1431
+ T + + H + + D I+V++ G++ E + LL+ D + F +A+ E
Sbjct: 815 GMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQ 874
Query: 1432 K 1432
+
Sbjct: 875 E 875
Score = 40.0 bits (92), Expect = 0.016
Identities = 34/125 (27%), Positives = 51/125 (40%), Gaps = 13/125 (10%)
Query: 574 LQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISG---------- 623
L L I++ I G+ VGI G G+GK+SL + EG I I G
Sbjct: 1306 LDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHD 1365
Query: 624 ---TFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGE 680
+ Q + + +LR N+ +Y +E + L L+ ++ LP E E
Sbjct: 1366 LRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAE 1425
Query: 681 RGANL 685
G NL
Sbjct: 1426 GGENL 1430
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 542 bits (1396), Expect = e-153
Identities = 329/881 (37%), Positives = 485/881 (55%), Gaps = 104/881 (11%)
Query: 577 TLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILN 636
TL+ I I EG LV + G VG GK+SL+SA+L +M +EG +AI G+ AYV QQAWI N
Sbjct: 660 TLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQN 719
Query: 637 ATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLA 696
+LR+NILFG + +E Y SV+ +C A+LP ++ G+
Sbjct: 720 DSLRENILFGCQLEEPYYRSVIQAC------ALLPDLEILPSGD---------------- 757
Query: 697 RALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFM 756
R + KT + VTH + YL D +I M
Sbjct: 758 --------------------------------RTEIGEKTRILVTHSMSYLPQVDVIIVM 785
Query: 757 KEGCITERGTHEELMNLNGDYATIFNNLLLGETPP-VEINSKKETSGSQKKSQ------- 808
G I+E G+++EL+ +G +A E E N SG K+++
Sbjct: 786 SGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGML 845
Query: 809 --DKGPK----------------------TGSVKKEKAVKPEEGQLVQLEEKGQGSVPWS 844
D K T ++K +A K E +L++ ++ G V S
Sbjct: 846 VTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLS 905
Query: 845 VYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVSDS 904
VY Y++A G ++FL I LFM N S S +WLS W N T T V S
Sbjct: 906 VYWDYMKAIGLFISFLSIF-LFMCNHVSALASNYWLSLWTDDPIVNGTQ---EHTKVRLS 961
Query: 905 MKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFD 964
+ + +++ SMAV + G + AS LH +L ILRSPM FF+
Sbjct: 962 VYGALGISQGIAVFGYSMAVSI------------GGILASRCLHVDLLHSILRSPMSFFE 1009
Query: 965 TTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVIL 1024
TP+G ++NRFSK++D VD +P +MF+ ++ V +I P + + PL ++
Sbjct: 1010 RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLI 1069
Query: 1025 FSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDN 1084
+ + R+LKRL+++++SP SH ++ G++ I A+ + + F+H+ +D+N
Sbjct: 1070 YFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDEN 1129
Query: 1085 QAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQ 1144
Q ++ A RWLAVRL+ + ++ L V+ + GL++SY++Q+T
Sbjct: 1130 QKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLN 1189
Query: 1145 FTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRE 1204
+ VR++SE E +VER+ Y +T EAP +I+ AP WPQ G V F N +RYRE
Sbjct: 1190 WLVRMSSEMETNIVAVERLKEYSET-EKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYRE 1248
Query: 1205 NLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLA 1264
+L VL+ ++ TI EK+GIVGRTG+GKSSL + LFR+ E + G I IDG+ I+ IGL
Sbjct: 1249 DLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLH 1308
Query: 1265 DLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVM 1324
DLR K++IIPQ+PVLFSG++R NLDPF+QY+++++W +LE H+K+ ++ LP KL+ E
Sbjct: 1309 DLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECA 1368
Query: 1325 ENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTI 1384
E G+N SVG+RQL+C+ARALLR KIL+LDEATAA+D ETD LIQ TIR F DCT+LTI
Sbjct: 1369 EGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTI 1428
Query: 1385 AHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAM 1425
AHRL+T++ R++VL +G++ E+ PS LL FY+M
Sbjct: 1429 AHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL-QQRGLFYSM 1468
Score = 146 bits (369), Expect = 1e-34
Identities = 113/450 (25%), Positives = 210/450 (46%), Gaps = 49/450 (10%)
Query: 100 PVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNE 159
P +A S +TF W++ L +++ L D+WSL+K ++S+ L + W++E +
Sbjct: 209 PESSASFLSRITFWWITGLIVRGYRQ-PLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAK 267
Query: 160 V----------GPDAA----------------------------SLRRVVWIFCRTRLIL 181
D A SL +V++ ++
Sbjct: 268 TRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLM 327
Query: 182 SIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWA 241
S I L FSGP + K L+++ T++ + L +T +++ L +
Sbjct: 328 SFFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFH 386
Query: 242 LNYRTGVRLRGAILTMAFKKILKLKNIKEKS--LGELINICSNDGQRMFEAAAVGSLLAG 299
+ + +G+R++ A++ ++K L + N KS +GE++N+ S D QR + A +++
Sbjct: 387 ICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWS 446
Query: 300 GPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMN 359
P+ IL + + LGP+ G AV +L P + T ++ + + D R++ MN
Sbjct: 447 APLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMN 506
Query: 360 EVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFS 419
E+L IK +K+YAW AF V IR+EE ++L+K+ Y ++ + ++ TF+
Sbjct: 507 EILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFA 566
Query: 420 VHMTLGFD--LTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVH 477
V++T+ + L A AF + +FN + F L + P + S+ +ASV++ R + EE+
Sbjct: 567 VYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELE 626
Query: 478 --MIKNKPASP---HIKIEMKNATLAWDSS 502
I+ +P I ++NAT W S
Sbjct: 627 PDSIERRPVKDGGGTNSITVRNATFTWARS 656
Score = 90.1 bits (222), Expect = 1e-17
Identities = 66/215 (30%), Positives = 99/215 (46%), Gaps = 14/215 (6%)
Query: 574 LQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISG---------- 623
L L I++ I G+ VGI G G+GK+SL + EG I I G
Sbjct: 1250 LDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHD 1309
Query: 624 ---TFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGE 680
+ Q + + +LR N+ +Y +E + L L+ ++ LP E E
Sbjct: 1310 LRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAE 1369
Query: 681 RGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFV 740
G NLS GQRQ + LARAL I +LD+ +A+D + + S IR + TVL +
Sbjct: 1370 GGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTI 1428
Query: 741 THQLQYLVDCDEVIFMKEGCITERGTHEELMNLNG 775
H+L ++D VI + +G I E G +L+ G
Sbjct: 1429 AHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG 1463
Score = 50.8 bits (120), Expect = 9e-06
Identities = 83/448 (18%), Positives = 177/448 (39%), Gaps = 56/448 (12%)
Query: 913 YYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRIL 972
Y ++ + L+L + FV G +R + + ++R+ L ++ G I+
Sbjct: 366 YTVLLFVTACLQTLVLHQYFHICFVSG-MRIKTAVIGAVYRKALVITNSARKSSTVGEIV 424
Query: 973 NRFSKDMDE-----VDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSV 1027
N S D + + + A + VIL + + + G P L V +V++ V
Sbjct: 425 NLMSVDAQRFMDLATYINMIWSAPL---QVILALYLLWLNLG--PSVLAGVAVMVLMVPV 479
Query: 1028 LHIVSRVL----IRELKRLDNITQSPFLSHITSSIQGLATIHAYN---KGQEFLHRYQEL 1080
+++ + +K DN + ++ I + I+ L ++A+ K + R +EL
Sbjct: 480 NAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNGIKVLK-LYAWELAFKDKVLAIRQEEL 536
Query: 1081 LDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLT 1140
++ + W+ + + T + + + I A ++ L
Sbjct: 537 KVLKKSAYLSAVGTFTWVCTPF----LVALCTFAVYVTIDENNILDAQTAFV---SLALF 589
Query: 1141 GLFQFTVRLA----SETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFE 1196
+ +F + + S S++R+ ++ LE P I+ + P D +T
Sbjct: 590 NILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELE-PDSIERR-PVKDGGGTNSITVR 647
Query: 1197 NAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGV 1256
NA + + P L ++F+I + +VG+ G GKSSL AL ++ G + I G
Sbjct: 648 NATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG- 706
Query: 1257 RISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLP 1316
++ +PQ+ + + ++R N+ LE + + I
Sbjct: 707 ------------SVAYVPQQAWIQNDSLRENI---------LFGCQLEEPYYRSVIQACA 745
Query: 1317 LKLESEVMENGDNFSVGERQLLCIARAL 1344
L + E++ +GD +GE+ + + ++
Sbjct: 746 LLPDLEILPSGDRTEIGEKTRILVTHSM 773
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 542 bits (1396), Expect = e-153
Identities = 318/794 (40%), Positives = 466/794 (58%), Gaps = 54/794 (6%)
Query: 668 AILPSSDLTE--IGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFN 725
A+L D E + +G NLSGGQ+QR+SLARA+YS+ IY+ DDPLSA+DAHVG HIF
Sbjct: 690 ALLAEMDKVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFE 749
Query: 726 SAI--RKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNN 783
+ I + LK+KT + VTH + YL D +I M G I+E G+++EL+ +G +A
Sbjct: 750 NVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRT 809
Query: 784 LLLGETPP-VEINSKKETSGSQKKSQ---------DKGPK-------------------- 813
E E N SG K+++ D K
Sbjct: 810 YASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHH 869
Query: 814 --TGSVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVG 871
T ++K +A K E +L++ ++ G V SVY Y++A G ++FL I LFM N
Sbjct: 870 NSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIF-LFMCNHV 928
Query: 872 STAFSTWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAI 931
S S +WLS W N T T V S+ + +++ SMAV +
Sbjct: 929 SALASNYWLSLWTDDPIVNGTQ---EHTKVRLSVYGALGISQGIAVFGYSMAVSI----- 980
Query: 932 RGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAE 991
G + AS LH +L ILRSPM FF+ TP+G ++NRFSK++D VD +P +
Sbjct: 981 -------GGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIK 1033
Query: 992 MFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFL 1051
MF+ ++ V +I P + + PL +++ + R+LKRL+++++SP
Sbjct: 1034 MFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVY 1093
Query: 1052 SHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALIT 1111
SH ++ G++ I A+ + + F+H+ +D+NQ ++ A RWLAVRL+ + ++
Sbjct: 1094 SHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVL 1153
Query: 1112 TTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLS 1171
L V+ + GL++SY++Q+T + VR++SE E +VER+ Y +T
Sbjct: 1154 FAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-E 1212
Query: 1172 LEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGS 1231
EAP +I+ AP WPQ G V F N +RYRE+L VL+ ++ TI EK+GIVGRTG+
Sbjct: 1213 KEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGA 1272
Query: 1232 GKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPF 1291
GKSSL + LFR+ E + G I IDG+ I+ IGL DLR K++IIPQ+PVLFSG++R NLDPF
Sbjct: 1273 GKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPF 1332
Query: 1292 NQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKIL 1351
+QY+++++W +LE H+K+ ++ LP KL+ E E G+N SVG+RQL+C+ARALLR KIL
Sbjct: 1333 SQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKIL 1392
Query: 1352 ILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTP 1411
+LDEATAA+D ETD LIQ TIR F DCT+LTIAHRL+T++ R++VL +G++ E+ P
Sbjct: 1393 VLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAP 1452
Query: 1412 SVLLSNDSSRFYAM 1425
S LL FY+M
Sbjct: 1453 SDLL-QQRGLFYSM 1465
Score = 146 bits (369), Expect = 1e-34
Identities = 113/450 (25%), Positives = 210/450 (46%), Gaps = 49/450 (10%)
Query: 100 PVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNE 159
P +A S +TF W++ L +++ L D+WSL+K ++S+ L + W++E +
Sbjct: 209 PESSASFLSRITFWWITGLIVRGYRQ-PLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAK 267
Query: 160 V----------GPDAA----------------------------SLRRVVWIFCRTRLIL 181
D A SL +V++ ++
Sbjct: 268 TRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLM 327
Query: 182 SIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWA 241
S I L FSGP + K L+++ T++ + L +T +++ L +
Sbjct: 328 SFFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFH 386
Query: 242 LNYRTGVRLRGAILTMAFKKILKLKNIKEKS--LGELINICSNDGQRMFEAAAVGSLLAG 299
+ + +G+R++ A++ ++K L + N KS +GE++N+ S D QR + A +++
Sbjct: 387 ICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWS 446
Query: 300 GPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMN 359
P+ IL + + LGP+ G AV +L P + T ++ + + D R++ MN
Sbjct: 447 APLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMN 506
Query: 360 EVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFS 419
E+L IK +K+YAW AF V IR+EE ++L+K+ Y ++ + ++ TF+
Sbjct: 507 EILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFA 566
Query: 420 VHMTLGFD--LTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVH 477
V++T+ + L A AF + +FN + F L + P + S+ +ASV++ R + EE+
Sbjct: 567 VYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELE 626
Query: 478 --MIKNKPASP---HIKIEMKNATLAWDSS 502
I+ +P I ++NAT W S
Sbjct: 627 PDSIERRPVKDGGGTNSITVRNATFTWARS 656
Score = 90.1 bits (222), Expect = 1e-17
Identities = 66/215 (30%), Positives = 99/215 (46%), Gaps = 14/215 (6%)
Query: 574 LQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT--------- 624
L L I++ I G+ VGI G G+GK+SL + EG I I G
Sbjct: 1247 LDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHD 1306
Query: 625 ----FAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGE 680
+ Q + + +LR N+ +Y +E + L L+ ++ LP E E
Sbjct: 1307 LRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAE 1366
Query: 681 RGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFV 740
G NLS GQRQ + LARAL I +LD+ +A+D + + S IR + TVL +
Sbjct: 1367 GGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTI 1425
Query: 741 THQLQYLVDCDEVIFMKEGCITERGTHEELMNLNG 775
H+L ++D VI + +G I E G +L+ G
Sbjct: 1426 AHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG 1460
Score = 50.4 bits (119), Expect = 1e-05
Identities = 24/47 (51%), Positives = 32/47 (68%)
Query: 577 TLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISG 623
TL+ I I EG LV + G VG GK+SL+SA+L +M +EG +AI G
Sbjct: 660 TLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG 706
Score = 45.1 bits (105), Expect = 5e-04
Identities = 72/363 (19%), Positives = 146/363 (40%), Gaps = 34/363 (9%)
Query: 913 YYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRIL 972
Y ++ + L+L + FV G +R + + ++R+ L ++ G I+
Sbjct: 366 YTVLLFVTACLQTLVLHQYFHICFVSG-MRIKTAVIGAVYRKALVITNSARKSSTVGEIV 424
Query: 973 NRFSKDMDE-----VDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSV 1027
N S D + + + A + VIL + + + G P L V +V++ V
Sbjct: 425 NLMSVDAQRFMDLATYINMIWSAPL---QVILALYLLWLNLG--PSVLAGVAVMVLMVPV 479
Query: 1028 LHIVSRVL----IRELKRLDNITQSPFLSHITSSIQGLATIHAYN---KGQEFLHRYQEL 1080
+++ + +K DN + ++ I + I+ L ++A+ K + R +EL
Sbjct: 480 NAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNGIKVLK-LYAWELAFKDKVLAIRQEEL 536
Query: 1081 LDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLT 1140
++ + W+ + + T + + + I A ++ L
Sbjct: 537 KVLKKSAYLSAVGTFTWVCTPF----LVALCTFAVYVTIDENNILDAQTAFV---SLALF 589
Query: 1141 GLFQFTVRLA----SETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFE 1196
+ +F + + S S++R+ ++ LE P I+ + P D +T
Sbjct: 590 NILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELE-PDSIERR-PVKDGGGTNSITVR 647
Query: 1197 NAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGV 1256
NA + + P L ++F+I + +VG+ G GKSSL AL ++ G + I GV
Sbjct: 648 NATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGV 707
Query: 1257 RIS 1259
+S
Sbjct: 708 NLS 710
Score = 45.1 bits (105), Expect = 5e-04
Identities = 30/120 (25%), Positives = 59/120 (49%), Gaps = 5/120 (4%)
Query: 1318 KLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETI---RE 1374
K+E V G N S G++Q + +ARA+ + I + D+ +A+D I E + +
Sbjct: 697 KVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKG 756
Query: 1375 AFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDS--SRFYAMFAAAENK 1432
+ T + + H + + D I+V++ G++ E + LL+ D + F +A+ E +
Sbjct: 757 MLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQE 816
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 530 bits (1366), Expect = e-150
Identities = 317/864 (36%), Positives = 479/864 (55%), Gaps = 46/864 (5%)
Query: 578 LHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNA 637
LH I+L + +G L+ + G VG+GK+SL+SA+LG+++ +EG ++I G AYV Q+AW+ N
Sbjct: 455 LHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNT 514
Query: 638 TLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLAR 697
++ +N+ FG+E D VL +C L+PD+ P T IGE+G NLSGGQ+QR+SLAR
Sbjct: 515 SVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLAR 574
Query: 698 ALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKH--LKSKTVLFVTHQLQYLVDCDEVIF 755
A+Y ++Y+LDDPL+ALDAHVG H+FN I L+ T + VTH L L D +I
Sbjct: 575 AVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIV 634
Query: 756 MKEGCITERGTHEELMNLNGDYATIFNNLLL------GETPP-VEINSKKETSGSQKKSQ 808
+ G I E G+++EL+ G + + GET P + TS ++
Sbjct: 635 LANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPEL 694
Query: 809 DKGPKTGSVKKEKAVKPEEGQLVQLEEKGQ------------GSVPWSVYGVYIQAAGGP 856
+ SV ++ E V L++ + G V +V+ Y++A G P
Sbjct: 695 RRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTP 754
Query: 857 LAFLVIMALFMLNVGSTAFSTWWLSYWIKQ----GSGNTTVTRGNETSVSDSMKDNPHMQ 912
L L + LF+ ++ +WLS W G RG + ++
Sbjct: 755 LC-LYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQA----- 808
Query: 913 YYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRIL 972
++A AV+L G RAS L L ++RSP+ FF+ TP G +L
Sbjct: 809 --IGLFASMAAVLL------------GGARASRLLFQRLLWDVVRSPISFFERTPIGHLL 854
Query: 973 NRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVS 1032
NRFSK+ D VDV +P + + + ++A P VA+ PL +L++ +
Sbjct: 855 NRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLY 914
Query: 1033 RVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFT 1092
V +L+RL++ + S SH+ + QG + A+ F+ + +D++Q F
Sbjct: 915 VVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRL 974
Query: 1093 CAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASE 1152
A RWLA ++L+ L+ VL + G ++S A+Q+T Q+ VR ++
Sbjct: 975 VADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTD 1034
Query: 1153 TEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKK 1212
E SVER+ Y T EAP R+ A P WPQ G++ F++ +RYR LPL ++
Sbjct: 1035 LENSIVSVERMQDYAWTPK-EAPWRLPTCAAQPPWPQGGQIEFQDFGLRYRPELPLAVQG 1093
Query: 1213 VSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSI 1272
VSF I EK+GIVGRTG+GKSSL L RL E + G I IDGV I+ +GL LRS++SI
Sbjct: 1094 VSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISI 1153
Query: 1273 IPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSV 1332
IPQ+P+LF G++R NLD +++++ IW ALE +K +A LP +L+ + + G++ SV
Sbjct: 1154 IPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSV 1213
Query: 1333 GERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVL 1392
G++QLLC+ARALLR +ILILDEATAA+D T+L +Q + FA CT+L IAHRL +V+
Sbjct: 1214 GQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVM 1273
Query: 1393 GSDRIMVLAQGQVVEFDTPSVLLS 1416
R++V+ +GQV E +P+ LL+
Sbjct: 1274 DCARVLVMDKGQVAESGSPAQLLA 1297
Score = 120 bits (301), Expect = 9e-27
Identities = 106/437 (24%), Positives = 191/437 (43%), Gaps = 39/437 (8%)
Query: 100 PVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEE--- 156
P A S TF W+S L +++ L +D+WSL + SS+ RLE+ W
Sbjct: 13 PETGAAFPSKATFWWVSGLVWRGYRR-PLRPKDLWSLGRENSSEELVSRLEKEWMRNRSA 71
Query: 157 --------------------------LNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQ 190
L + G L + +W + +L + L+I+
Sbjct: 72 ARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISD 131
Query: 191 LAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRL 250
+ F+ P ++ LE+ + LL + + L+ +++ +RL
Sbjct: 132 VFRFTVPK-LLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRL 190
Query: 251 RGAILTMAFKKILKLKNIKEKS--LGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGM 308
R AI + ++K+L L + K+ +G+++N+ S D QR+ E+ + L V ++
Sbjct: 191 RSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCF 250
Query: 309 IYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFI 368
+Y +LGP+ AVF+ P F S+ + + + + D R + + +L K I
Sbjct: 251 VYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTI 310
Query: 369 KMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFD- 427
K + W AF V IR +E L +G S+++ + + ++V F+VH + +
Sbjct: 311 KFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENA 370
Query: 428 LTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEE-----VHMIKNK 482
+ A +AF +TV N + A PFS+ SL +A V+ DR + +EE V +
Sbjct: 371 MNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPGAVDSSSSG 430
Query: 483 PASPHIKIEMKNATLAW 499
A+ I +++AT AW
Sbjct: 431 SAAGKDCITIQSATFAW 447
Score = 89.7 bits (221), Expect = 2e-17
Identities = 63/216 (29%), Positives = 104/216 (48%), Gaps = 16/216 (7%)
Query: 574 LQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT--------- 624
L + + +I G+ VGI G G+GK+SL S +L EG I I G
Sbjct: 1087 LPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHT 1146
Query: 625 ----FAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGE 680
+ + Q + +LR N+ +E+ +E + L + L+ +A LP + +
Sbjct: 1147 LRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCAD 1206
Query: 681 RGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHI-FNSAIRKHLKSKTVLF 739
RG +LS GQ+Q + LARAL I ILD+ +A+D G + + + TVL
Sbjct: 1207 RGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDP--GTELQMQAMLGSWFAQCTVLL 1264
Query: 740 VTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNG 775
+ H+L+ ++DC V+ M +G + E G+ +L+ G
Sbjct: 1265 IAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKG 1300
Score = 75.1 bits (183), Expect = 5e-13
Identities = 58/226 (25%), Positives = 105/226 (46%), Gaps = 16/226 (7%)
Query: 1193 VTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIK 1252
+T ++A + + P L +++ T+ + +VG G+GKSSL AL L ELS K
Sbjct: 438 ITIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSAL--LGELS----K 491
Query: 1253 IDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECI 1312
++ G + ++ +PQE + + +V N+ + + LE ++ +
Sbjct: 492 VE-------GFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDV 544
Query: 1313 AQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETI 1372
P + + + E G N S G++Q L +ARA+ R + +LD+ AA+D + +
Sbjct: 545 DSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQV 604
Query: 1373 ---REAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLL 1415
T + + H LH + +D I+VLA G + E + LL
Sbjct: 605 IGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELL 650
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 530 bits (1364), Expect = e-150
Identities = 317/864 (36%), Positives = 478/864 (55%), Gaps = 46/864 (5%)
Query: 578 LHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNA 637
LH I+L + +G L+ + G VG+GK+SL+SA+LG+++ +EG ++I G AYV Q+AW+ N
Sbjct: 646 LHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNT 705
Query: 638 TLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLAR 697
++ +N+ FG+E D VL +C L+PD+ P T IGE+G NLSGGQ+QR+SLAR
Sbjct: 706 SVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLAR 765
Query: 698 ALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKH--LKSKTVLFVTHQLQYLVDCDEVIF 755
A+Y ++Y+LDDPL+ALDAHVG H+FN I L+ T + VTH L L D +I
Sbjct: 766 AVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIV 825
Query: 756 MKEGCITERGTHEELMNLNGDYATIFNNLLL------GETPP-VEINSKKETSGSQKKSQ 808
+ G I E G+++EL+ G + + GET P + TS ++
Sbjct: 826 LANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPEL 885
Query: 809 DKGPKTGSVKKEKAVKPEEGQLVQLEEKGQ------------GSVPWSVYGVYIQAAGGP 856
+ SV ++ E V L++ + G V +V+ Y++A G P
Sbjct: 886 RRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTP 945
Query: 857 LAFLVIMALFMLNVGSTAFSTWWLSYWIKQ----GSGNTTVTRGNETSVSDSMKDNPHMQ 912
L L + LF+ ++ +WLS W G RG + ++
Sbjct: 946 LC-LYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQA----- 999
Query: 913 YYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRIL 972
++A AV+L G RAS L L ++RSP+ FF+ TP G +L
Sbjct: 1000 --IGLFASMAAVLL------------GGARASRLLFQRLLWDVVRSPISFFERTPIGHLL 1045
Query: 973 NRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVS 1032
NRFSK+ D VDV +P + + + ++A P VA+ PL +L++ +
Sbjct: 1046 NRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLY 1105
Query: 1033 RVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFT 1092
V +L+RL++ + S SH+ + QG + A+ F+ + +D++Q F
Sbjct: 1106 VVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRL 1165
Query: 1093 CAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASE 1152
A RWLA ++L+ L+ VL + G ++S A+Q+T Q+ VR ++
Sbjct: 1166 VADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTD 1225
Query: 1153 TEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKK 1212
E SVER+ Y T EAP R+ A P WPQ G++ F + +RYR LPL ++
Sbjct: 1226 LENSIVSVERMQDYAWTPK-EAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQG 1284
Query: 1213 VSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSI 1272
VSF I EK+GIVGRTG+GKSSL L RL E + G I IDGV I+ +GL LRS++SI
Sbjct: 1285 VSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISI 1344
Query: 1273 IPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSV 1332
IPQ+P+LF G++R NLD +++++ IW ALE +K +A LP +L+ + + G++ SV
Sbjct: 1345 IPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSV 1404
Query: 1333 GERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVL 1392
G++QLLC+ARALLR +ILILDEATAA+D T+L +Q + FA CT+L IAHRL +V+
Sbjct: 1405 GQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVM 1464
Query: 1393 GSDRIMVLAQGQVVEFDTPSVLLS 1416
R++V+ +GQV E +P+ LL+
Sbjct: 1465 DCARVLVMDKGQVAESGSPAQLLA 1488
Score = 119 bits (299), Expect = 2e-26
Identities = 106/437 (24%), Positives = 190/437 (43%), Gaps = 39/437 (8%)
Query: 100 PVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEE--- 156
P A S TF W+S L +++ L +D+WSL + SS+ RLE+ W
Sbjct: 204 PETGAAFPSKATFWWVSGLVWRGYRR-PLRPKDLWSLGRENSSEELVSRLEKEWMRNRSA 262
Query: 157 --------------------------LNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQ 190
L + G L + +W + +L + L+I+
Sbjct: 263 ARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISD 322
Query: 191 LAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRL 250
+ F+ P ++ LE+ + LL + + L+ +++ +RL
Sbjct: 323 VFRFTVPK-LLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRL 381
Query: 251 RGAILTMAFKKILKLKNIKEKS--LGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGM 308
R AI + ++K+L L + K+ +G+++N+ S D QR+ E+ + L V ++
Sbjct: 382 RSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCF 441
Query: 309 IYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFI 368
+Y +LGP+ AVF+ P F S+ + + + + D R + + +L K I
Sbjct: 442 VYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTI 501
Query: 369 KMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFD- 427
K + W AF V IR +E L +G S+++ + + ++V F+VH + +
Sbjct: 502 KFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENA 561
Query: 428 LTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEE-----VHMIKNK 482
+ A +AF +TV N + A PFS+ SL +A V+ DR + +EE V +
Sbjct: 562 MNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPGVVDSSSSG 621
Query: 483 PASPHIKIEMKNATLAW 499
A+ I + +AT AW
Sbjct: 622 SAAGKDCITIHSATFAW 638
Score = 89.7 bits (221), Expect = 2e-17
Identities = 63/216 (29%), Positives = 104/216 (48%), Gaps = 16/216 (7%)
Query: 574 LQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT--------- 624
L + + +I G+ VGI G G+GK+SL S +L EG I I G
Sbjct: 1278 LPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHT 1337
Query: 625 ----FAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGE 680
+ + Q + +LR N+ +E+ +E + L + L+ +A LP + +
Sbjct: 1338 LRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCAD 1397
Query: 681 RGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHI-FNSAIRKHLKSKTVLF 739
RG +LS GQ+Q + LARAL I ILD+ +A+D G + + + TVL
Sbjct: 1398 RGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDP--GTELQMQAMLGSWFAQCTVLL 1455
Query: 740 VTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNG 775
+ H+L+ ++DC V+ M +G + E G+ +L+ G
Sbjct: 1456 IAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKG 1491
Score = 74.3 bits (181), Expect = 8e-13
Identities = 58/226 (25%), Positives = 104/226 (46%), Gaps = 16/226 (7%)
Query: 1193 VTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIK 1252
+T +A + + P L +++ T+ + +VG G+GKSSL AL L ELS K
Sbjct: 629 ITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSAL--LGELS----K 682
Query: 1253 IDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECI 1312
++ G + ++ +PQE + + +V N+ + + LE ++ +
Sbjct: 683 VE-------GFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDV 735
Query: 1313 AQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETI 1372
P + + + E G N S G++Q L +ARA+ R + +LD+ AA+D + +
Sbjct: 736 DSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQV 795
Query: 1373 ---REAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLL 1415
T + + H LH + +D I+VLA G + E + LL
Sbjct: 796 IGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELL 841
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 474 bits (1221), Expect = e-133
Identities = 280/730 (38%), Positives = 418/730 (57%), Gaps = 50/730 (6%)
Query: 728 IRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLG 787
+ H+ KT + VTH + YL D +I M G I+E G+++EL+ +G +A
Sbjct: 698 VEGHVAIKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYAST 757
Query: 788 ETPP-VEINSKKETSGSQKKSQ---------DKGPK----------------------TG 815
E E N SG K+++ D K T
Sbjct: 758 EQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTA 817
Query: 816 SVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAF 875
++K +A K E +L++ ++ G V SVY Y++A G ++FL I LFM N S
Sbjct: 818 ELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIF-LFMCNHVSALA 876
Query: 876 STWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVV 935
S +WLS W N T T V S+ + +++ SMAV +
Sbjct: 877 SNYWLSLWTDDPIVNGTQ---EHTKVRLSVYGALGISQGIAVFGYSMAVSI--------- 924
Query: 936 FVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQ 995
G + AS LH +L ILRSPM FF+ TP+G ++NRFSK++D VD +P +MF+
Sbjct: 925 ---GGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMG 981
Query: 996 NVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHIT 1055
++ V +I P + + PL +++ + R+LKRL+++++SP SH
Sbjct: 982 SLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFN 1041
Query: 1056 SSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGL 1115
++ G++ I A+ + + F+H+ +D+NQ ++ A RWLAVRL+ + ++ L
Sbjct: 1042 ETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAAL 1101
Query: 1116 MIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAP 1175
V+ + GL++SY++Q+T + VR++SE E +VER+ Y +T EAP
Sbjct: 1102 FAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAP 1160
Query: 1176 ARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSS 1235
+I+ AP WPQ G V F N +RYRE+L VL+ ++ TI EK+GIVGRTG+GKSS
Sbjct: 1161 WQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSS 1220
Query: 1236 LGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYT 1295
L + LFR+ E + G I IDG+ I+ IGL DLR K++IIPQ+PVLFSG++R NLDPF+QY+
Sbjct: 1221 LTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYS 1280
Query: 1296 EDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDE 1355
++++W +LE H+K+ ++ LP KL+ E E G+N SVG+RQL+C+ARALLR KIL+LDE
Sbjct: 1281 DEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDE 1340
Query: 1356 ATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLL 1415
ATAA+D ETD LIQ TIR F DCT+LTIAHRL+T++ R++VL +G++ E+ PS LL
Sbjct: 1341 ATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL 1400
Query: 1416 SNDSSRFYAM 1425
FY+M
Sbjct: 1401 -QQRGLFYSM 1409
Score = 146 bits (369), Expect = 1e-34
Identities = 113/450 (25%), Positives = 210/450 (46%), Gaps = 49/450 (10%)
Query: 100 PVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNE 159
P +A S +TF W++ L +++ L D+WSL+K ++S+ L + W++E +
Sbjct: 209 PESSASFLSRITFWWITGLIVRGYRQ-PLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAK 267
Query: 160 V----------GPDAA----------------------------SLRRVVWIFCRTRLIL 181
D A SL +V++ ++
Sbjct: 268 TRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLM 327
Query: 182 SIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWA 241
S I L FSGP + K L+++ T++ + L +T +++ L +
Sbjct: 328 SFFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFH 386
Query: 242 LNYRTGVRLRGAILTMAFKKILKLKNIKEKS--LGELINICSNDGQRMFEAAAVGSLLAG 299
+ + +G+R++ A++ ++K L + N KS +GE++N+ S D QR + A +++
Sbjct: 387 ICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWS 446
Query: 300 GPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMN 359
P+ IL + + LGP+ G AV +L P + T ++ + + D R++ MN
Sbjct: 447 APLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMN 506
Query: 360 EVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFS 419
E+L IK +K+YAW AF V IR+EE ++L+K+ Y ++ + ++ TF+
Sbjct: 507 EILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFA 566
Query: 420 VHMTLGFD--LTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVH 477
V++T+ + L A AF + +FN + F L + P + S+ +ASV++ R + EE+
Sbjct: 567 VYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELE 626
Query: 478 --MIKNKPASP---HIKIEMKNATLAWDSS 502
I+ +P I ++NAT W S
Sbjct: 627 PDSIERRPVKDGGGTNSITVRNATFTWARS 656
Score = 90.1 bits (222), Expect = 1e-17
Identities = 66/215 (30%), Positives = 99/215 (46%), Gaps = 14/215 (6%)
Query: 574 LQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT--------- 624
L L I++ I G+ VGI G G+GK+SL + EG I I G
Sbjct: 1191 LDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHD 1250
Query: 625 ----FAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGE 680
+ Q + + +LR N+ +Y +E + L L+ ++ LP E E
Sbjct: 1251 LRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAE 1310
Query: 681 RGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFV 740
G NLS GQRQ + LARAL I +LD+ +A+D + + S IR + TVL +
Sbjct: 1311 GGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTI 1369
Query: 741 THQLQYLVDCDEVIFMKEGCITERGTHEELMNLNG 775
H+L ++D VI + +G I E G +L+ G
Sbjct: 1370 AHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG 1404
Score = 48.1 bits (113), Expect = 6e-05
Identities = 23/45 (51%), Positives = 31/45 (68%)
Query: 577 TLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAI 621
TL+ I I EG LV + G VG GK+SL+SA+L +M +EG +AI
Sbjct: 660 TLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704
Score = 39.3 bits (90), Expect = 0.028
Identities = 69/357 (19%), Positives = 142/357 (39%), Gaps = 34/357 (9%)
Query: 913 YYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRIL 972
Y ++ + L+L + FV G +R + + ++R+ L ++ G I+
Sbjct: 366 YTVLLFVTACLQTLVLHQYFHICFVSG-MRIKTAVIGAVYRKALVITNSARKSSTVGEIV 424
Query: 973 NRFSKDMDE-----VDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSV 1027
N S D + + + A + VIL + + + G P L V +V++ V
Sbjct: 425 NLMSVDAQRFMDLATYINMIWSAPL---QVILALYLLWLNLG--PSVLAGVAVMVLMVPV 479
Query: 1028 LHIVSRVL----IRELKRLDNITQSPFLSHITSSIQGLATIHAYN---KGQEFLHRYQEL 1080
+++ + +K DN + ++ I + I+ L ++A+ K + R +EL
Sbjct: 480 NAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNGIKVLK-LYAWELAFKDKVLAIRQEEL 536
Query: 1081 LDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLT 1140
++ + W+ + + T + + + I A ++ L
Sbjct: 537 KVLKKSAYLSAVGTFTWVCTPF----LVALCTFAVYVTIDENNILDAQTAFV---SLALF 589
Query: 1141 GLFQFTVRLA----SETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFE 1196
+ +F + + S S++R+ ++ LE P I+ + P D +T
Sbjct: 590 NILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELE-PDSIERR-PVKDGGGTNSITVR 647
Query: 1197 NAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKI 1253
NA + + P L ++F+I + +VG+ G GKSSL AL ++ G + I
Sbjct: 648 NATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704
>gi|66529093 ATP-binding cassette, sub-family C, member 5 isoform 2
[Homo sapiens]
Length = 208
Score = 404 bits (1038), Expect = e-112
Identities = 198/199 (99%), Positives = 198/199 (99%)
Query: 1 MKDIDIGKEYIIPSPGYRSVRERTSTSGTHRDREDSKFRRTRPLECQDALETAARAEGLS 60
MKDIDIGKEYIIPSPGYRSVRERTSTSGTHRDREDSKFRRTRPLECQDALETAARAEGLS
Sbjct: 1 MKDIDIGKEYIIPSPGYRSVRERTSTSGTHRDREDSKFRRTRPLECQDALETAARAEGLS 60
Query: 61 LDASMHSQLRILDEEHPKGKYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLAR 120
LDASMHSQLRILDEEHPKGKYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLAR
Sbjct: 61 LDASMHSQLRILDEEHPKGKYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLAR 120
Query: 121 VAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNEVGPDAASLRRVVWIFCRTRLI 180
VAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNEVGPDAASLRRVVWIFCRTRLI
Sbjct: 121 VAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNEVGPDAASLRRVVWIFCRTRLI 180
Query: 181 LSIVCLMITQLAGFSGPAF 199
LSIVCLMITQLAGFSGP F
Sbjct: 181 LSIVCLMITQLAGFSGPNF 199
>gi|90421313 cystic fibrosis transmembrane conductance regulator [Homo
sapiens]
Length = 1480
Score = 298 bits (764), Expect = 2e-80
Identities = 175/595 (29%), Positives = 316/595 (53%), Gaps = 23/595 (3%)
Query: 843 WSVYGVYIQAAGGPLAFLV-IMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSV 901
W+ Y YI + L+ + +F+ V ++ W L Q GN+T +R N +V
Sbjct: 846 WNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRNNSYAV 905
Query: 902 SDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMK 961
+ + ++ Y IY +L + RG+ V + S LH ++ +L++PM
Sbjct: 906 IITSTSSYYVFY---IYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMS 962
Query: 962 FFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPL 1021
+T G ILNRFSKD+ +D LP FIQ +++V + ++A + P+ VA P+
Sbjct: 963 TLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPV 1022
Query: 1022 VILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELL 1081
++ F +L ++LK+L++ +SP +H+ +S++GL T+ A+ + F + + L
Sbjct: 1023 IVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
Query: 1082 DDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTG 1141
+ + A +FL+ +RW +R+++I + + +L G+ G+ ++ A+ +
Sbjct: 1083 NLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGE-GEGRVGIILTLAMNIMS 1141
Query: 1142 LFQFTVRLASETEARFTSVERINHYIKTLSLEAPAR---------------IKNKAPSPD 1186
Q+ V + + ++ SV R+ +I + P + I+N D
Sbjct: 1142 TLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKD 1201
Query: 1187 --WPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLV 1244
WP G++T ++ +Y E +L+ +SF+I P +++G++GRTGSGKS+L A RL+
Sbjct: 1202 DIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLL 1261
Query: 1245 ELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALE 1304
G I+IDGV I L R +IPQ+ +FSGT R NLDP+ Q+++ +IW +
Sbjct: 1262 NTEGE-IQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVAD 1320
Query: 1305 RTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTET 1364
++ I Q P KL+ +++ G S G +QL+C+AR++L KIL+LDE +A +D T
Sbjct: 1321 EVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVT 1380
Query: 1365 DLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDS 1419
+I+ T+++AFADCT++ HR+ +L + +V+ + +V ++D+ LL+ S
Sbjct: 1381 YQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS 1435
Score = 243 bits (621), Expect = 7e-64
Identities = 172/689 (24%), Positives = 333/689 (48%), Gaps = 60/689 (8%)
Query: 100 PVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEEL-N 158
P++ A + S + FSW + R +++ L + D++ + +S+D +LER W EL +
Sbjct: 5 PLEKASVVSKLFFSWTRPILRKGYRQ-RLELSDIYQIPSVDSADNLSEKLEREWDRELAS 63
Query: 159 EVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYS 218
+ P + R + + R + + L + ++ P + + + Y + +
Sbjct: 64 KKNPKLINALRRCFFW---RFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIA 120
Query: 219 LLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKLKN--IKEKSLGEL 276
+ L +GL L IVR+ L + G+++R A+ ++ +KK LKL + + + S+G+L
Sbjct: 121 IYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQL 180
Query: 277 INICSNDGQRMFEAAAVGSLLAGGP--VVAILGMIYNVIILGPTGFLGSAVFILFYPAMM 334
+++ SN+ + E A+ + P V ++G+I+ ++ LG + + + A +
Sbjct: 181 VSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGL 240
Query: 335 FASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEK 394
R+ +R + ER+ +E++ I+ +K Y W +A + ++ +R+ E ++ K
Sbjct: 241 --GRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRK 298
Query: 395 AGY---FQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFAL-KVT 450
A Y F S + VV SV+ +++ + + FT ++ + A+ +
Sbjct: 299 AAYVRYFNSSAFFFSGFFVVFLSVLPYALIK----GIILRKIFTTISFCIVLRMAVTRQF 354
Query: 451 PFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSP 510
P++V++ ++ A+++ + +E ++ + ++ M+N T W+ +
Sbjct: 355 PWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTT--EVVMENVTAFWEEGFGELF--- 409
Query: 511 KLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLG 570
EK +Q +++ R + ++
Sbjct: 410 -----------------EKAKQ-------------------NNNNRKTSNGDDSLFFSNF 433
Query: 571 HLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQ 630
L L I+ +I+ G+L+ + GS G+GKTSL+ I+G++ EG I SG ++ +Q
Sbjct: 434 SLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQ 493
Query: 631 QAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQR 690
+WI+ T+++NI+FG YDE RY SV+ +C L D++ D +GE G LSGGQR
Sbjct: 494 FSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQR 553
Query: 691 QRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDC 750
RISLARA+Y D +Y+LD P LD IF S + K + +KT + VT ++++L
Sbjct: 554 ARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKA 613
Query: 751 DEVIFMKEGCITERGTHEELMNLNGDYAT 779
D+++ + EG GT EL NL D+++
Sbjct: 614 DKILILHEGSSYFYGTFSELQNLQPDFSS 642
Score = 80.1 bits (196), Expect = 1e-14
Identities = 54/208 (25%), Positives = 103/208 (49%), Gaps = 15/208 (7%)
Query: 578 LHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT------------- 624
L +I I G+ VG+ G GSGK++L+SA L ++ EG I I G
Sbjct: 1227 LENISFSISPGQRVGLLGRTGSGKSTLLSAFL-RLLNTEGEIQIDGVSWDSITLQQWRKA 1285
Query: 625 FAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGAN 684
F + Q+ +I + T R N+ +++ ++ V + LR + P + + G
Sbjct: 1286 FGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCV 1345
Query: 685 LSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQL 744
LS G +Q + LAR++ S I +LD+P + LD V I +++ TV+ H++
Sbjct: 1346 LSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIRRTLKQAFADCTVILCEHRI 1404
Query: 745 QYLVDCDEVIFMKEGCITERGTHEELMN 772
+ +++C + + ++E + + + ++L+N
Sbjct: 1405 EAMLECQQFLVIEENKVRQYDSIQKLLN 1432
Score = 69.3 bits (168), Expect = 2e-11
Identities = 55/224 (24%), Positives = 104/224 (46%), Gaps = 29/224 (12%)
Query: 1209 VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRS 1268
VLK ++F I+ + + + G TG+GK+SL M + +E S G IK G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
Query: 1269 KLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGD 1328
++S Q + GT++ N+ Y E + ++ ++E I++ K + E G
Sbjct: 487 RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGI 546
Query: 1329 NFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQET-IREAFADCTMLTIAHR 1387
S G+R + +ARA+ + + +LD +D T+ I E+ + + A+ T + + +
Sbjct: 547 TLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSK 606
Query: 1388 LHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAEN 1431
+ + +D+I++L +G SS FY F+ +N
Sbjct: 607 MEHLKKADKILILHEG---------------SSYFYGTFSELQN 635
>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
[Homo sapiens]
Length = 859
Score = 281 bits (718), Expect = 4e-75
Identities = 153/429 (35%), Positives = 242/429 (56%), Gaps = 20/429 (4%)
Query: 577 TLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILN 636
TL + ++ G+L+ + G VG+GK+SL+SA+LG++ G +++ G AYV+QQ W+ +
Sbjct: 427 TLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFS 486
Query: 637 ATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLA 696
TLR NILFGK+Y++ERY V+ +C L+ DL +L DLT IG+RG LSGGQ+ R++LA
Sbjct: 487 GTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLA 546
Query: 697 RALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFM 756
RA+Y D IY+LDDPLSA+DA V H+F I + L K + VTHQLQYL +++ +
Sbjct: 547 RAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILIL 606
Query: 757 KEGCITERGTHEELMNLNGDYATIF-NNLLLGETPPV----EINSKKETSGSQKKSQDKG 811
K+G + ++GT+ E + D+ ++ + E PPV + ++ + S Q
Sbjct: 607 KDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSR 666
Query: 812 PKTGSVKKEKAVKPEEGQLVQL----EEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFM 867
P K+ A++ ++ + V + E + +G V + Y Y +A + F+ ++ L
Sbjct: 667 PSL----KDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNT 722
Query: 868 LNVGSTAFSTWWLSYWI-KQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVML 926
+ WWLSYW KQ N TV G ++ + + +Y IY+ +
Sbjct: 723 AAQVAYVLQDWWLSYWANKQSMLNVTVNGGG------NVTEKLDLNWYLGIYSGLTVATV 776
Query: 927 ILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRL 986
+ R ++ + +S LH+++F IL++P+ FFD P GRILNRFSKD+ +D L
Sbjct: 777 LFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLL 836
Query: 987 PFQAEMFIQ 995
P FIQ
Sbjct: 837 PLTFLDFIQ 845
Score = 144 bits (362), Expect = 8e-34
Identities = 108/419 (25%), Positives = 207/419 (49%), Gaps = 22/419 (5%)
Query: 99 HPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELN 158
+P+ +A L S + F WL+ L ++ HK+ L +D++S+ + S L+ W +E+
Sbjct: 11 NPLQDANLCSRVFFWWLNPLFKIGHKR-RLEEDDMYSVLPEDRSQHLGEELQGFWDKEVL 69
Query: 159 EVGPDAAS---LRRVVWIFCRTRLILSIVCLMITQLAGFSGPAFMVKHLLEYTQ------ 209
DA R ++ + ++ L+L I L I + A P F+ K ++ Y +
Sbjct: 70 RAENDAQKPSLTRAIIKCYWKSYLVLGIFTL-IEESAKVIQPIFLGK-IINYFENYDPMD 127
Query: 210 --ATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKLKN 267
A + Y+ +L L+ I+ L + G+RLR A+ M ++K L+L N
Sbjct: 128 SVALNTAYAYATVLTFCTLILAILHH----LYFYHVQCAGMRLRVAMCHMIYRKALRLSN 183
Query: 268 IK--EKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAV 325
+ + + G+++N+ SND + + L GP+ AI + +G + G AV
Sbjct: 184 MAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAV 243
Query: 326 FILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIR 385
I+ P +L + R K TD R++ MNEV+T I+ IKMYAW K+FS + +R
Sbjct: 244 LIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLR 303
Query: 386 EEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTF 445
++E + ++ + + + I VTF+ ++ LG +TA++ F VT++ ++
Sbjct: 304 KKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRL 363
Query: 446 ALKV-TPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNK-PASPHIKIEMKNATLAWDSS 502
+ + P +++ +SEA V++ R ++ L++E+ + P+ + +++ T WD +
Sbjct: 364 TVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKA 422
Score = 89.7 bits (221), Expect = 2e-17
Identities = 113/510 (22%), Positives = 218/510 (42%), Gaps = 29/510 (5%)
Query: 914 YASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILN 973
YA++ ++ IL + +R + ++R+ LR T TG+I+N
Sbjct: 137 YATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVN 196
Query: 974 RFSKDM---DEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHI 1030
S D+ D+V V L F +Q I V + M G+ L + L+IL +
Sbjct: 197 LLSNDVNKFDQVTVFLHFLWAGPLQ-AIAVTALLWMEIGIS--CLAGMAVLIILLPLQSC 253
Query: 1031 VSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFL 1090
++ + T + + + I G+ I Y + F + L +
Sbjct: 254 FGKLFSSLRSKTATFTDARIRT-MNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILR 312
Query: 1091 FTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISY--AVQLTGLFQFTVR 1148
+C S ++ T VL+ I + +A++ AV+LT F
Sbjct: 313 SSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSA 372
Query: 1149 LASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPL 1208
+ +EA S+ RI + L L+ ++ + PS D + V A P
Sbjct: 373 IERVSEA-IVSIRRIQTF---LLLDEISQRNRQLPS-DGKKMVHVQDFTAFWDKASETP- 426
Query: 1209 VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRS 1268
L+ +SFT++P E + +VG G+GKSSL A+ + S G + + G
Sbjct: 427 TLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG------------- 473
Query: 1269 KLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGD 1328
+++ + Q+P +FSGT+RSN+ +Y +++ ++ +K+ + L + + + G
Sbjct: 474 RIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGT 533
Query: 1329 NFSVGERQLLCIARALLRHCKILILDEATAAMDTETDL-LIQETIREAFADCTMLTIAHR 1387
S G++ + +ARA+ + I +LD+ +A+D E L + I + + + + H+
Sbjct: 534 TLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQ 593
Query: 1388 LHTVLGSDRIMVLAQGQVVEFDTPSVLLSN 1417
L + + +I++L G++V+ T + L +
Sbjct: 594 LQYLKAASQILILKDGKMVQKGTYTEFLKS 623
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 239 bits (611), Expect = 1e-62
Identities = 277/1199 (23%), Positives = 497/1199 (41%), Gaps = 204/1199 (17%)
Query: 307 GMIYNVIILGPTGFLGSAVFILFYPAMMFASR-LTAYFRRKCVAATDERVQKMNEVLTYI 365
G ++IL + LG + + F + L AY + VA EVL I
Sbjct: 211 GWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVA---------EEVLAAI 261
Query: 366 KFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTF--SVHMT 423
+ + + K + K EE +RI K +I++G A +++ + + F +
Sbjct: 262 RTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLV 321
Query: 424 LGFDLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKP 483
L + + Q V+TVF F++ + FSV +AS +++ F
Sbjct: 322 LSGEYSIGQ---VLTVF----FSVLIGAFSV---GQASPSIEAFA--------------- 356
Query: 484 ASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLA 543
NA A I N P + K S K + +
Sbjct: 357 ----------NARGAAYEIFKIIDNKPSIDSYSK-----SGHKPDNI------------- 388
Query: 544 EQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTS 603
KG+L + P +E K L ++L++Q G+ V + G+ G GK++
Sbjct: 389 --KGNLEFRNVHFSYPSRKEVK-----------ILKGLNLKVQSGQTVALVGNSGCGKST 435
Query: 604 LISAILGQMTLLEGSIAISGT-------------FAYVAQQAWILNATLRDNILFGKE-Y 649
+ + EG +++ G V+Q+ + T+ +NI +G+E
Sbjct: 436 TVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENV 495
Query: 650 DEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILD 709
+ + + LP T +GERGA LSGGQ+QRI++ARAL + I +LD
Sbjct: 496 TMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD 555
Query: 710 DPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEE 769
+ SALD + A+ K K +T + + H+L + + D + +G I E+G H+E
Sbjct: 556 EATSALDTE-SEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDE 614
Query: 770 LMNLNGDYATIFNNLLLG--------------ETPPVEINSKKETSGSQKKSQDKGPKTG 815
LM G Y + G E +E++S S +K + G
Sbjct: 615 LMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRG 674
Query: 816 SVKKEKAVKPEEG--------QLVQLEEKGQGSVPWSVYGVYIQAAGGPL--AFLVIMAL 865
S +++ + +E ++ + P+ V GV+ G L AF +I +
Sbjct: 675 SQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSK 734
Query: 866 FMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVM 925
+ G T + D + ++ ++ +
Sbjct: 735 II----------------------------GVFTRIDDPETKRQNSNLFSLLFLALGIIS 766
Query: 926 LILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDT--TPTGRILNRFSKDMDEVD 983
I ++G F K + RL +FR +LR + +FD TG + R + D +V
Sbjct: 767 FITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVK 826
Query: 984 VRLPFQAEMFIQNVILVFFCVGMIAGVFPW----FLVAVGPLVILFSVLHI--VSRVLIR 1037
+ + + QN+ + + +I+ ++ W L+A+ P++ + V+ + +S ++
Sbjct: 827 GAIGSRLAVITQNIANLGTGI-IISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALK 885
Query: 1038 ELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPF--------- 1088
+ K L+ + T +I+ T+ + + Q+F H Y + L Q P+
Sbjct: 886 DKKELEGSGKIA-----TEAIENFRTVVSLTQEQKFEHMYAQSL---QVPYRNSLRKAHI 937
Query: 1089 ----FLFTCAMRWLAVR------LDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQ 1138
F FT AM + + L++ L++ +++V A+ +
Sbjct: 938 FGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFS-----------AVVFGAM 986
Query: 1139 LTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENA 1198
G Q + +A+ ++ I KT +++ + P+ EG VTF
Sbjct: 987 AVG--QVSSFAPDYAKAKISAAHIIMIIEKTPLIDS---YSTEGLMPN-TLEGNVTFGEV 1040
Query: 1199 EMRY--RENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGV 1256
Y R ++P VL+ +S +K + + +VG +G GKS++ L R + G + +DG
Sbjct: 1041 VFNYPTRPDIP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGK 1099
Query: 1257 RISDIGLADLRSKLSIIPQEPVLFSGTVRSNL---DPFNQYTEDQIWDALERTHMKECIA 1313
I + + LR+ L I+ QEP+LF ++ N+ D ++++I A + ++ I
Sbjct: 1100 EIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIE 1159
Query: 1314 QLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIR 1373
LP K ++V + G S G++Q + IARAL+R IL+LDEAT+A+DTE++ ++QE +
Sbjct: 1160 SLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD 1219
Query: 1374 EAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENK 1432
+A T + IAHRL T+ +D I+V G+V E T LL+ F + A K
Sbjct: 1220 KAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTK 1278
Score = 150 bits (378), Expect = 1e-35
Identities = 140/533 (26%), Positives = 247/533 (46%), Gaps = 40/533 (7%)
Query: 897 NETSVSDS---MKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFR 953
N + ++D+ M M YA Y+ A +L+ I+ + R ++ + F
Sbjct: 94 NRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFH 153
Query: 954 RILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVF--FCVGMIAGVF 1011
I+R + +FD G + R + D+ +++ + + MF Q++ F F VG G
Sbjct: 154 AIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRG-- 211
Query: 1012 PWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSS------IQGLATIH 1065
W L V ++ + VL + + V K L + T L++ + + + T+
Sbjct: 212 -WKLTLV--ILAISPVLGLSAAVW---AKILSSFTDKELLAYAKAGAVAEEVLAAIRTVI 265
Query: 1066 AYNKGQEFLHRYQELLDDNQAPFFLFTCAMR---WLAVRLDLISIALITTTGLMIVLMH- 1121
A+ ++ L RY + L++ + A L S AL G +VL
Sbjct: 266 AFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGE 325
Query: 1122 ---GQIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARI 1178
GQ+ + + I F+V AS + F + + I + P+ I
Sbjct: 326 YSIGQVLTVFFSVLIG---------AFSVGQASPSIEAFANARGAAYEIFKIIDNKPS-I 375
Query: 1179 KNKAPSPDWPQ--EGEVTFENAEMRYRENLPL-VLKKVSFTIKPKEKIGIVGRTGSGKSS 1235
+ + S P +G + F N Y + +LK ++ ++ + + +VG +G GKS+
Sbjct: 376 DSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKST 435
Query: 1236 LGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQ-Y 1294
+ RL + + G + +DG I I + LR + ++ QEPVLF+ T+ N+ +
Sbjct: 436 TVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENV 495
Query: 1295 TEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILD 1354
T D+I A++ + + I +LP K ++ V E G S G++Q + IARAL+R+ KIL+LD
Sbjct: 496 TMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD 555
Query: 1355 EATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVE 1407
EAT+A+DTE++ ++Q + +A T + IAHRL TV +D I G +VE
Sbjct: 556 EATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVE 608
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 238 bits (608), Expect = 2e-62
Identities = 285/1171 (24%), Positives = 501/1171 (42%), Gaps = 188/1171 (16%)
Query: 292 AVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAAT 351
AV + AG V I G ++I+ + LG + A ++A L+A F K +AA
Sbjct: 198 AVATFFAGFIVGFIRGWKLTLVIMAISPILGLS-------AAVWAKILSA-FSDKELAAY 249
Query: 352 DERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVV 411
+ E L I+ + + + QK E + I K +I++G+A +++
Sbjct: 250 AKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIY 309
Query: 412 IASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMT--FALKVTPFSVKSLSEASVAVDRFKS 469
+ + F G L ++ +T+ N+MT F++ + FSV +A+ +D F
Sbjct: 310 ASYALAF----WYGSTLVISKEYTIG---NAMTVFFSILIGAFSV---GQAAPCIDAFA- 358
Query: 470 LFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEK 529
N + ++ ++ I N+PK+ D + RG K
Sbjct: 359 -----------NARGAAYVIFDI-------------IDNNPKI------DSFSERGHKPD 388
Query: 530 VRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGK 589
KG+L + P K L ++L++Q G+
Sbjct: 389 --------------SIKGNLEFNDVHFSYPSRANVK-----------ILKGLNLKVQSGQ 423
Query: 590 LVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT-------------FAYVAQQAWILN 636
V + GS G GK++ + I EG+I I G V+Q+ + +
Sbjct: 424 TVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFS 483
Query: 637 ATLRDNILFGK-EYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISL 695
T+ +NI +G+ + + + LP T +GERGA LSGGQ+QRI++
Sbjct: 484 TTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAI 543
Query: 696 ARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIF 755
ARAL + I +LD+ SALD + +A+ K + +T + + H+L + + D +
Sbjct: 544 ARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHRLSTVRNADVIAG 602
Query: 756 MKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKKETSGSQKKSQDKGPKTG 815
++G I E+G+H ELM G Y + N +T +I S++ +K + P
Sbjct: 603 FEDGVIVEQGSHSELMKKEGVYFKLVNM----QTSGSQIQSEEFELNDEKAATRMAPNGW 658
Query: 816 SVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAF 875
K + + + ++ + Q S+ G ++A P++FL ++ L
Sbjct: 659 ---KSRLFRHSTQKNLKNSQMCQKSLDVETDG--LEANVPPVSFLKVLKLN--------- 704
Query: 876 STWWLSYWIKQGSGNTTVTRGNETSVSDSMK---------DNPHMQYYASIYALSMAVML 926
T W + + G+ G + + S D+ Q +I++L +
Sbjct: 705 KTEWPYFVV--GTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLG 762
Query: 927 ILKA----IRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDT--TPTGRILNRFSKDMD 980
I+ ++G F K + RL F+ +LR M +FD TG + R + D
Sbjct: 763 IISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAA 822
Query: 981 EVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPW----FLVAVGPLVILFSVLHIVSRVLI 1036
+V + + QN+ + + +I+ ++ W L+AV P++ + ++ + ++L
Sbjct: 823 QVQGATGTRLALIAQNIANLGTGI-IISFIYGWQLTLLLLAVVPIIAVSGIVEM--KLLA 879
Query: 1037 RELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMR 1096
KR D T +I+ + T+ + + ++F Y E L P+ +F+ A+
Sbjct: 880 GNAKR-DKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKL---YGPYRVFS-AIV 934
Query: 1097 WLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASETEAR 1156
+ AV L S P YA +S A L LF+ + S +E
Sbjct: 935 FGAVALGHAS----------------SFAPDYAKAKLS-AAHLFMLFERQPLIDSYSE-- 975
Query: 1157 FTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRY--RENLPLVLKKVS 1214
+ PD EG +TF Y R N+P VL+ +S
Sbjct: 976 ------------------------EGLKPD-KFEGNITFNEVVFNYPTRANVP-VLQGLS 1009
Query: 1215 FTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIP 1274
+K + + +VG +G GKS++ L R + G + +DG + + LR++L I+
Sbjct: 1010 LEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVS 1069
Query: 1275 QEPVLFSGTVRSNL---DPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFS 1331
QEP+LF ++ N+ D ++D+I A + ++ I LP K E+ V + G S
Sbjct: 1070 QEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLS 1129
Query: 1332 VGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTV 1391
G++Q + IARAL+R +IL+LDEAT+A+DTE++ ++QE + +A T + IAHRL T+
Sbjct: 1130 GGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTI 1189
Query: 1392 LGSDRIMVLAQGQVVEFDTPSVLLSNDSSRF 1422
+D I+V G+V E T LL+ F
Sbjct: 1190 QNADLIVVFQNGRVKEHGTHQQLLAQKGIYF 1220
Score = 147 bits (371), Expect = 7e-35
Identities = 141/534 (26%), Positives = 248/534 (46%), Gaps = 43/534 (8%)
Query: 911 MQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGR 970
M YA Y+ A +L+ I+ + R ++ + F ILR + +FD T
Sbjct: 113 MTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTE 172
Query: 971 ILNRFSKDMDEVDVRLPFQAEMFIQNVILVF--FCVGMIAGVFPWFLVAVGPLVILFSVL 1028
+ R + D+ ++ + + MF Q V F F VG I G W L V ++ + +L
Sbjct: 173 LNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRG---WKLTLV--IMAISPIL 227
Query: 1029 HIVSRVLIRELKRLDNITQSPFL---SHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQ 1085
+ + V + L + + + + ++ + T+ A+ + L RYQ+ L++
Sbjct: 228 GLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLEN-- 285
Query: 1086 APFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAY---AGLAIS--YAV--Q 1138
+ + ++ +I+ + G+ +L++ A+ + L IS Y +
Sbjct: 286 ---------AKEIGIKK---AISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNA 333
Query: 1139 LTGLFQ-----FTVRLASETEARFTSVERINHYIKTLSLEAPA--RIKNKAPSPDWPQEG 1191
+T F F+V A+ F + + I + P + PD +G
Sbjct: 334 MTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPD-SIKG 392
Query: 1192 EVTFENAEMRY--RENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGG 1249
+ F + Y R N+ +LK ++ ++ + + +VG +G GKS+ + RL + G
Sbjct: 393 NLEFNDVHFSYPSRANVK-ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451
Query: 1250 CIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNL-DPFNQYTEDQIWDALERTHM 1308
I IDG I + + LR + ++ QEPVLFS T+ N+ T D+I A++ +
Sbjct: 452 TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANA 511
Query: 1309 KECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLI 1368
E I +LP K ++ V E G S G++Q + IARAL+R+ KIL+LDEAT+A+DTE++ +
Sbjct: 512 YEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571
Query: 1369 QETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRF 1422
Q + +A T + IAHRL TV +D I G +VE + S L+ + F
Sbjct: 572 QAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYF 625
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 235 bits (600), Expect = 2e-61
Identities = 281/1185 (23%), Positives = 504/1185 (42%), Gaps = 169/1185 (14%)
Query: 292 AVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAAT 351
AV + AG V I G ++I+ + LG + A ++A L+A F K +AA
Sbjct: 198 AVATFFAGFIVGFIRGWKLTLVIMAISPILGLS-------AAVWAKILSA-FSDKELAAY 249
Query: 352 DERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVV 411
+ E L I+ + + + QK E + I K +I++G+A +++
Sbjct: 250 AKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIY 309
Query: 412 IASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMT--FALKVTPFSVKSLSEASVAVDRFKS 469
+ + F G L ++ +T+ N+MT F++ + FSV +A+ +D F
Sbjct: 310 ASYALAF----WYGSTLVISKEYTIG---NAMTVFFSILIGAFSV---GQAAPCIDAFA- 358
Query: 470 LFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEK 529
N + ++ ++ I N+PK+ D + RG K
Sbjct: 359 -----------NARGAAYVIFDI-------------IDNNPKI------DSFSERGHKPD 388
Query: 530 VRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGK 589
KG+L + P K L ++L++Q G+
Sbjct: 389 --------------SIKGNLEFNDVHFSYPSRANVK-----------ILKGLNLKVQSGQ 423
Query: 590 LVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT-------------FAYVAQQAWILN 636
V + GS G GK++ + I EG+I I G V+Q+ + +
Sbjct: 424 TVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFS 483
Query: 637 ATLRDNILFGK-EYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISL 695
T+ +NI +G+ + + + LP T +GERGA LSGGQ+QRI++
Sbjct: 484 TTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAI 543
Query: 696 ARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIF 755
ARAL + I +LD+ SALD + +A+ K + +T + + H+L + + D +
Sbjct: 544 ARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHRLSTVRNADVIAG 602
Query: 756 MKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKKETSGSQKKSQDKGPKTG 815
++G I E+G+H ELM G Y + N +T +I S++ +K + P
Sbjct: 603 FEDGVIVEQGSHSELMKKEGVYFKLVNM----QTSGSQIQSEEFELNDEKAATRMAPNGW 658
Query: 816 SVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAF 875
K + + + ++ + Q S+ G ++A P++FL ++ L
Sbjct: 659 ---KSRLFRHSTQKNLKNSQMCQKSLDVETDG--LEANVPPVSFLKVLKLN--------- 704
Query: 876 STWWLSYWIKQGSGNTTVTRGNETSVSDSMK---------DNPHMQYYASIYALSMAVML 926
T W + + G+ G + + S D+ Q +I++L +
Sbjct: 705 KTEWPYFVV--GTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLG 762
Query: 927 ILKA----IRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDT--TPTGRILNRFSKDMD 980
I+ ++G F K + RL F+ +LR M +FD TG + R + D
Sbjct: 763 IISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAA 822
Query: 981 EVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPW----FLVAVGPLVILFSVLHIVSRVLI 1036
+V + + QN+ + + +I+ ++ W L+AV P++ + ++ + ++L
Sbjct: 823 QVQGATGTRLALIAQNIANLGTGI-IISFIYGWQLTLLLLAVVPIIAVSGIVEM--KLLA 879
Query: 1037 RELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELL------DDNQAPFFL 1090
KR D T +I+ + T+ + + ++F Y E L +A +
Sbjct: 880 GNAKR-DKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYG 938
Query: 1091 FTCAMRWLAVRLDLISI----ALITTTGLM----IVLMHGQIPPAYAGLAISYAVQLTGL 1142
T ++ + A + G M ++L+ I + +A+ +A
Sbjct: 939 ITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAI--VFGAVALGHASSFAPD 996
Query: 1143 FQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRY 1202
+ A+ F I+ Y + PD EG +TF Y
Sbjct: 997 YAKAKLSAAHLFMLFERQPLIDSY------------SEEGLKPD-KFEGNITFNEVVFNY 1043
Query: 1203 --RENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISD 1260
R N+P VL+ +S +K + + +VG +G GKS++ L R + G + +DG
Sbjct: 1044 PTRANVP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKK 1102
Query: 1261 IGLADLRSKLSIIPQEPVLFSGTVRSNL---DPFNQYTEDQIWDALERTHMKECIAQLPL 1317
+ + LR++L I+ QEP+LF ++ N+ D ++D+I A + ++ I LP
Sbjct: 1103 LNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPH 1162
Query: 1318 KLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFA 1377
K E+ V + G S G++Q + IARAL+R +IL+LDEAT+A+DTE++ ++QE + +A
Sbjct: 1163 KYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKARE 1222
Query: 1378 DCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRF 1422
T + IAHRL T+ +D I+V G+V E T LL+ F
Sbjct: 1223 GRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYF 1267
Score = 147 bits (371), Expect = 7e-35
Identities = 141/534 (26%), Positives = 248/534 (46%), Gaps = 43/534 (8%)
Query: 911 MQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGR 970
M YA Y+ A +L+ I+ + R ++ + F ILR + +FD T
Sbjct: 113 MTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTE 172
Query: 971 ILNRFSKDMDEVDVRLPFQAEMFIQNVILVF--FCVGMIAGVFPWFLVAVGPLVILFSVL 1028
+ R + D+ ++ + + MF Q V F F VG I G W L V ++ + +L
Sbjct: 173 LNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRG---WKLTLV--IMAISPIL 227
Query: 1029 HIVSRVLIRELKRLDNITQSPFL---SHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQ 1085
+ + V + L + + + + ++ + T+ A+ + L RYQ+ L++
Sbjct: 228 GLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLEN-- 285
Query: 1086 APFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAY---AGLAIS--YAV--Q 1138
+ + ++ +I+ + G+ +L++ A+ + L IS Y +
Sbjct: 286 ---------AKEIGIKK---AISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNA 333
Query: 1139 LTGLFQ-----FTVRLASETEARFTSVERINHYIKTLSLEAPA--RIKNKAPSPDWPQEG 1191
+T F F+V A+ F + + I + P + PD +G
Sbjct: 334 MTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPD-SIKG 392
Query: 1192 EVTFENAEMRY--RENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGG 1249
+ F + Y R N+ +LK ++ ++ + + +VG +G GKS+ + RL + G
Sbjct: 393 NLEFNDVHFSYPSRANVK-ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451
Query: 1250 CIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNL-DPFNQYTEDQIWDALERTHM 1308
I IDG I + + LR + ++ QEPVLFS T+ N+ T D+I A++ +
Sbjct: 452 TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANA 511
Query: 1309 KECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLI 1368
E I +LP K ++ V E G S G++Q + IARAL+R+ KIL+LDEAT+A+DTE++ +
Sbjct: 512 YEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571
Query: 1369 QETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRF 1422
Q + +A T + IAHRL TV +D I G +VE + S L+ + F
Sbjct: 572 QAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYF 625
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 228 bits (582), Expect = 2e-59
Identities = 281/1192 (23%), Positives = 504/1192 (42%), Gaps = 176/1192 (14%)
Query: 292 AVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAAT 351
AV + AG V I G ++I+ + LG + A ++A L+A F K +AA
Sbjct: 198 AVATFFAGFIVGFIRGWKLTLVIMAISPILGLS-------AAVWAKILSA-FSDKELAAY 249
Query: 352 DERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVV 411
+ E L I+ + + + QK E + I K +I++G+A +++
Sbjct: 250 AKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIY 309
Query: 412 IASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMT--FALKVTPFSVKSLSEASVAVDRFKS 469
+ + F G L ++ +T+ N+MT F++ + FSV +A+ +D F
Sbjct: 310 ASYALAF----WYGSTLVISKEYTIG---NAMTVFFSILIGAFSV---GQAAPCIDAFA- 358
Query: 470 LFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEK 529
N + ++ ++ I N+PK+ D + RG K
Sbjct: 359 -----------NARGAAYVIFDI-------------IDNNPKI------DSFSERGHKPD 388
Query: 530 VRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGK 589
KG+L + P K L ++L++Q G+
Sbjct: 389 --------------SIKGNLEFNDVHFSYPSRANVK-----------ILKGLNLKVQSGQ 423
Query: 590 LVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT-------------FAYVAQQAWILN 636
V + GS G GK++ + I EG+I I G V+Q+ + +
Sbjct: 424 TVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFS 483
Query: 637 ATLRDNILFGK-EYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISL 695
T+ +NI +G+ + + + LP T +GERGA LSGGQ+QRI++
Sbjct: 484 TTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAI 543
Query: 696 ARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIF 755
ARAL + I +LD+ SALD + +A+ K + +T + + H+L + + D +
Sbjct: 544 ARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHRLSTVRNADVIAG 602
Query: 756 MKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKKETSGSQKKSQDKGPKTG 815
++G I E+G+H ELM G Y + N +T +I S++ +K + P
Sbjct: 603 FEDGVIVEQGSHSELMKKEGVYFKLVNM----QTSGSQIQSEEFELNDEKAATRMAPNGW 658
Query: 816 SVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAF 875
K + + + ++ + Q S+ G ++A P++FL ++ L
Sbjct: 659 ---KSRLFRHSTQKNLKNSQMCQKSLDVETDG--LEANVPPVSFLKVLKLN--------- 704
Query: 876 STWWLSYWIKQGSGNTTVTRGNETSVSDSMK---------DNPHMQYYASIYALSMAVML 926
T W + + G+ G + + S D+ Q +I++L +
Sbjct: 705 KTEWPYFVV--GTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLG 762
Query: 927 ILKA----IRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDT--TPTGRILNRFSKDMD 980
I+ ++G F K + RL F+ +LR M +FD TG + R + D
Sbjct: 763 IISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAA 822
Query: 981 EVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPW----FLVAVGPLVILFSVLHIVSRVLI 1036
+V + + QN+ + + +I+ ++ W L+AV P++ + ++ + ++L
Sbjct: 823 QVQGATGTRLALIAQNIANLGTGI-IISFIYGWQLTLLLLAVVPIIAVSGIVEM--KLLA 879
Query: 1037 RELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELL------DDNQAPFFL 1090
KR D T +I+ + T+ + + ++F Y E L +A +
Sbjct: 880 GNAKR-DKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYG 938
Query: 1091 FTCAMRWLAVRLDLISI----ALITTTGLM----IVLMHGQIPPAYAGLAISYAVQLTGL 1142
T ++ + A + G M ++L+ I + +A+ +A
Sbjct: 939 ITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAI--VFGAVALGHASSFAPD 996
Query: 1143 FQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRY 1202
+ A+ F I+ Y + PD EG +TF Y
Sbjct: 997 YAKAKLSAAHLFMLFERQPLIDSY------------SEEGLKPD-KFEGNITFNEVVFNY 1043
Query: 1203 --RENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKID------ 1254
R N+P VL+ +S +K + + +VG +G GKS++ L R + G + +D
Sbjct: 1044 PTRANVP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLL 1102
Query: 1255 -GVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNL---DPFNQYTEDQIWDALERTHMKE 1310
G + + LR++L I+ QEP+LF ++ N+ D ++D+I A + ++
Sbjct: 1103 DGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHP 1162
Query: 1311 CIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQE 1370
I LP K E+ V + G S G++Q + IARAL+R +IL+LDEAT+A+DTE++ ++QE
Sbjct: 1163 FIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQE 1222
Query: 1371 TIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRF 1422
+ +A T + IAHRL T+ +D I+V G+V E T LL+ F
Sbjct: 1223 ALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYF 1274
Score = 147 bits (371), Expect = 7e-35
Identities = 141/534 (26%), Positives = 248/534 (46%), Gaps = 43/534 (8%)
Query: 911 MQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGR 970
M YA Y+ A +L+ I+ + R ++ + F ILR + +FD T
Sbjct: 113 MTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTE 172
Query: 971 ILNRFSKDMDEVDVRLPFQAEMFIQNVILVF--FCVGMIAGVFPWFLVAVGPLVILFSVL 1028
+ R + D+ ++ + + MF Q V F F VG I G W L V ++ + +L
Sbjct: 173 LNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRG---WKLTLV--IMAISPIL 227
Query: 1029 HIVSRVLIRELKRLDNITQSPFL---SHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQ 1085
+ + V + L + + + + ++ + T+ A+ + L RYQ+ L++
Sbjct: 228 GLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLEN-- 285
Query: 1086 APFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAY---AGLAIS--YAV--Q 1138
+ + ++ +I+ + G+ +L++ A+ + L IS Y +
Sbjct: 286 ---------AKEIGIKK---AISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNA 333
Query: 1139 LTGLFQ-----FTVRLASETEARFTSVERINHYIKTLSLEAPA--RIKNKAPSPDWPQEG 1191
+T F F+V A+ F + + I + P + PD +G
Sbjct: 334 MTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPD-SIKG 392
Query: 1192 EVTFENAEMRY--RENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGG 1249
+ F + Y R N+ +LK ++ ++ + + +VG +G GKS+ + RL + G
Sbjct: 393 NLEFNDVHFSYPSRANVK-ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451
Query: 1250 CIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNL-DPFNQYTEDQIWDALERTHM 1308
I IDG I + + LR + ++ QEPVLFS T+ N+ T D+I A++ +
Sbjct: 452 TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANA 511
Query: 1309 KECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLI 1368
E I +LP K ++ V E G S G++Q + IARAL+R+ KIL+LDEAT+A+DTE++ +
Sbjct: 512 YEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571
Query: 1369 QETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRF 1422
Q + +A T + IAHRL TV +D I G +VE + S L+ + F
Sbjct: 572 QAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYF 625
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 205 bits (521), Expect = 3e-52
Identities = 217/915 (23%), Positives = 378/915 (41%), Gaps = 107/915 (11%)
Query: 576 RTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISG------------ 623
+ L+ +++ I+ G++ + G G+GK++ + I EG + + G
Sbjct: 436 KILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLR 495
Query: 624 -TFAYVAQQAWILNATLRDNILFGKE-----------YDEERYNSVLNSCCLRPDLAILP 671
V Q+ + + T+ +NI +G+E + YN +++ LP
Sbjct: 496 DQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMD----------LP 545
Query: 672 SSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKH 731
T +GE G +SGGQ+QR+++ARAL + I +LD SALD + + + K
Sbjct: 546 QQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALD-NESEAMVQEVLSKI 604
Query: 732 LKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPP 791
T++ V H+L + D +I + G ERGTHEEL+ G Y T+ G
Sbjct: 605 QHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQAL 664
Query: 792 VEINSKKETSGSQ-KKSQDKGPKTGSV--------KKEKAVKPEEGQLVQLEEKGQGSVP 842
E + K T ++ +G S+ K + + E L ++ K
Sbjct: 665 NEEDIKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEED 724
Query: 843 WSVYGVYIQAAGGPLAFLVIMAL------FMLNVGSTAFS-----TWWLSYWIKQGSGNT 891
+ +Q P I+ +ML VGS + T ++ Q G
Sbjct: 725 RKDKDIPVQEEVEPAPVRRILKFSAPEWPYML-VGSVGAAVNGTVTPLYAFLFSQILGTF 783
Query: 892 TVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDEL 951
S+ D + + ++ V L + ++G F K + RL
Sbjct: 784 --------SIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFG 835
Query: 952 FRRILRSPMKFFDT--TPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAG 1009
FR +L + +FD G + R + D +V Q M + + V + +IA
Sbjct: 836 FRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAM-IIAF 894
Query: 1010 VFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPF--LSHITS-SIQGLATIHA 1066
F W L V ++ F L + R L + + + IT+ ++ + T+
Sbjct: 895 SFSWKLSLV--ILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAG 952
Query: 1067 YNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPP 1126
K + F+ + L+ PF + + ++ +M +
Sbjct: 953 IGKERRFIEALETELEK---PF-------KTAIQKANIYGFCFAFAQCIMFIANSASY-- 1000
Query: 1127 AYAGLAISYAVQLTGL-FQFTVRLASETEARFTSVERINHY--------------IKTLS 1171
Y G Y + GL F + R+ S T++ R Y + L
Sbjct: 1001 RYGG----YLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLD 1056
Query: 1172 LEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPL-VLKKVSFTIKPKEKIGIVGRTG 1230
+ P + N A +G++ F + + Y VL +S +I P + + VG +G
Sbjct: 1057 RQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSG 1116
Query: 1231 SGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNL-- 1288
GKS+ L R + G + IDG + + LRS + I+ QEPVLF+ ++ N+
Sbjct: 1117 CGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKY 1176
Query: 1289 -DPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRH 1347
D + +++ A ++ + + + LP K E+ V G S GE+Q + IARA++R
Sbjct: 1177 GDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRD 1236
Query: 1348 CKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVE 1407
KIL+LDEAT+A+DTE++ +Q + +A T + IAHRL T+ +D I V+AQG V+E
Sbjct: 1237 PKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIE 1296
Query: 1408 FDTPSVLLSNDSSRF 1422
T L++ + +
Sbjct: 1297 KGTHEELMAQKGAYY 1311
Score = 151 bits (381), Expect = 5e-36
Identities = 142/547 (25%), Positives = 242/547 (44%), Gaps = 29/547 (5%)
Query: 890 NTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHD 949
N +T G + + M +AS YA +LI I+ +V R ++
Sbjct: 120 NQNMTNGTRCGL---LNIESEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRK 176
Query: 950 ELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVF--FCVGMI 1007
FRRI+R + +FD G + RFS D+++++ + Q +FIQ + F +G
Sbjct: 177 FYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFF 236
Query: 1008 AG-VFPWFLVAVGPLVIL--FSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATI 1064
G +++V PL+ + ++ VS+ ELK + SS++ T+
Sbjct: 237 RGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKA--GVVADEVISSMR---TV 291
Query: 1065 HAYNKGQEFLHRYQELLDDNQ------APFFLFTCAMRWLAVRLDLISIALITTTGLMIV 1118
A+ + + RY++ L Q F W + + AL G +V
Sbjct: 292 AAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLI---FLCYALAFWYGSTLV 348
Query: 1119 LMHGQIPPA-YAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAPAR 1177
L G+ P + +S V L + L + R + + ++ +
Sbjct: 349 LDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSE 408
Query: 1178 IKNKAPSPDWPQEGEVTFENAEMRYRENLPL-VLKKVSFTIKPKEKIGIVGRTGSGKSSL 1236
K +GE+ F N Y + +L ++ IKP E +VG +G+GKS+
Sbjct: 409 DGYKLDRI----KGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTA 464
Query: 1237 GMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQ-YT 1295
+ R + G + +DG I + + LR ++ I+ QEPVLFS T+ N+ + T
Sbjct: 465 LQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDAT 524
Query: 1296 EDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDE 1355
+ I A + + I LP + ++ V E G S G++Q + IARAL+R+ KIL+LD
Sbjct: 525 MEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDM 584
Query: 1356 ATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLL 1415
AT+A+D E++ ++QE + + T++++AHRL TV +D I+ G VE T LL
Sbjct: 585 ATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELL 644
Query: 1416 SNDSSRF 1422
F
Sbjct: 645 ERKGVYF 651
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 204 bits (518), Expect = 6e-52
Identities = 198/842 (23%), Positives = 368/842 (43%), Gaps = 117/842 (13%)
Query: 628 VAQQAWILNATLRDNILFGKE-YDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLS 686
V+Q+ + T+ +NI +G++ +E + P+ T +GE+GA +S
Sbjct: 22 VSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEFPNKFNTLVGEKGAQMS 81
Query: 687 GGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQY 746
GGQ+QRI++ARAL + I ILD+ SALD+ + + +A+ K K +T + V H+L
Sbjct: 82 GGQKQRIAIARALVRNPKILILDEATSALDSESKSAV-QAALEKASKGRTTIVVAHRLST 140
Query: 747 LVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKKETSGSQKK 806
+ D ++ +K+G + E+G H ELM G Y ++ ++ + + + T +++K
Sbjct: 141 IRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSL---VMSQDIKKADEQMESMTYSTERK 197
Query: 807 SQD------KGPKTGSVKK------EKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAG 854
+ K K+ + K K + E L+++ + + P+ V G
Sbjct: 198 TNSLPLHSVKSIKSDFIDKAEESTQSKEISLPEVSLLKILKLNKPEWPFVVLGTLASVLN 257
Query: 855 GPL--AFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQ 912
G + F +I A + G+ N T ++ +
Sbjct: 258 GTVHPVFSIIFAKIITMFGN-----------------NDKTTLKHDAEI----------- 289
Query: 913 YYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDT--TPTGR 970
Y+ I+ + + + ++G+ + + + RL F+ +L + +FD TG
Sbjct: 290 -YSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGG 348
Query: 971 ILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPW----FLVAVGPLVILFS 1026
+ + D+ ++ + + QN + V +I+ ++ W ++++ P++ +
Sbjct: 349 LTTILAIDIAQIQGATGSRIGVLTQNATNMGLSV-IISFIYGWEMTFLILSIAPVLAVTG 407
Query: 1027 VLHIVSRVLI-----RELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELL 1081
++ + +ELK I T +++ + TI + + + F Y+E+L
Sbjct: 408 MIETAAMTGFANKDKQELKHAGKIA--------TEALENIRTIVSLTREKAFEQMYEEML 459
Query: 1082 DDNQAP-------------------FFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHG 1122
+F + R+ A LI +T G+ IV
Sbjct: 460 QTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAY---LIQAGRMTPEGMFIVFT-- 514
Query: 1123 QIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKA 1182
AI+Y G T+ LA E + + LE I +++
Sbjct: 515 ---------AIAYGAMAIGE---TLVLAPEYSKAKSGAAHL-----FALLEKKPNIDSRS 557
Query: 1183 PSPDWPQ--EGEVTFENAEMRY--RENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGM 1238
P EG + F Y R ++ +L+ +S +I+ + + VG +G GKS+
Sbjct: 558 QEGKKPDTCEGNLEFREVSFFYPCRPDV-FILRGLSLSIERGKTVAFVGSSGCGKSTSVQ 616
Query: 1239 ALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNL---DPFNQYT 1295
L RL + G + DGV ++ + LRS+++I+PQEPVLF+ ++ N+ D
Sbjct: 617 LLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVP 676
Query: 1296 EDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDE 1355
D+I +A ++ I LP K ++V G S G++Q L IARALL+ KIL+LDE
Sbjct: 677 LDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDE 736
Query: 1356 ATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLL 1415
AT+A+D +++ ++Q + +A T L + HRL + +D I+VL G++ E T LL
Sbjct: 737 ATSALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELL 796
Query: 1416 SN 1417
N
Sbjct: 797 RN 798
Score = 102 bits (253), Expect = 3e-21
Identities = 64/221 (28%), Positives = 107/221 (48%), Gaps = 17/221 (7%)
Query: 578 LHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT------------- 624
L + L I+ GK V GS G GK++ + + ++G + G
Sbjct: 588 LRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQ 647
Query: 625 FAYVAQQAWILNATLRDNILFG---KEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGER 681
A V Q+ + N ++ +NI +G + + N+ + + LP T++G +
Sbjct: 648 IAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLK 707
Query: 682 GANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVT 741
GA LSGGQ+QR+++ARAL I +LD+ SALD + + A+ K +T L VT
Sbjct: 708 GAQLSGGQKQRLAIARALLQKPKILLLDEATSALD-NDSEKVVQHALDKARTGRTCLVVT 766
Query: 742 HQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFN 782
H+L + + D ++ + G I E+GTH+EL+ Y + N
Sbjct: 767 HRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVN 807
Score = 96.3 bits (238), Expect = 2e-19
Identities = 57/183 (31%), Positives = 101/183 (55%), Gaps = 2/183 (1%)
Query: 1253 IDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLD-PFNQYTEDQIWDALERTHMKEC 1311
+D I + + R + ++ QEPVLF T+ +N+ + T++++ A + +
Sbjct: 2 VDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDF 61
Query: 1312 IAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQET 1371
I + P K + V E G S G++Q + IARAL+R+ KILILDEAT+A+D+E+ +Q
Sbjct: 62 IMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAA 121
Query: 1372 IREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAEN 1431
+ +A T + +AHRL T+ +D I+ L G + E + L++ +Y++ + +
Sbjct: 122 LEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAK-RGLYYSLVMSQDI 180
Query: 1432 KVA 1434
K A
Sbjct: 181 KKA 183
>gi|73747915 transporter 2, ATP-binding cassette, sub-family B isoform
1 [Homo sapiens]
Length = 703
Score = 167 bits (423), Expect = 7e-41
Identities = 135/499 (27%), Positives = 250/499 (50%), Gaps = 53/499 (10%)
Query: 932 RGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAE 991
RG F R + R+ ++LF +LR + FF T TG + +R S D + LP A
Sbjct: 210 RGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNAN 269
Query: 992 MFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRV------------LIREL 1039
+ +++++ V G F++++ P + L S+LH+ + ++RE+
Sbjct: 270 VLLRSLVKVVGLYG--------FMLSISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREI 321
Query: 1040 KRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLD---------DNQAPFFL 1090
+ D + ++ + + ++ GL T+ ++ + + RY+E L+ D + +L
Sbjct: 322 Q--DAVARAGQV--VREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYL 377
Query: 1091 FTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLA 1150
+ L V++ ++S L + G++ + Y + Q V +
Sbjct: 378 LVRRVLHLGVQMLMLSCGLQQ-------MQDGELTQGSLLSFMIYQESVGSYVQTLVYIY 430
Query: 1151 SETEARFTSVERINHYI-KTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRY--RENLP 1207
+ + + E++ Y+ + +L +P + AP+ +G V F++ Y R + P
Sbjct: 431 GDMLSNVGAAEKVFSYMDRQPNLPSPGTL---APTT---LQGVVKFQDVSFAYPNRPDRP 484
Query: 1208 LVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLR 1267
VLK ++FT++P E +VG GSGKS++ L L + +GG + +D IS L
Sbjct: 485 -VLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLH 543
Query: 1268 SKLSIIPQEPVLFSGTVRSNLDPFNQYTE-DQIWDALERTHMKECIAQLPLKLESEVMEN 1326
S++ + QEPVLFSG+VR+N+ Q E D++ A + H + I ++ + ++V E
Sbjct: 544 SQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEK 603
Query: 1327 GDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAH 1386
G + G++Q L IARAL+R ++LILDEAT+A+D + + +Q+ + D T+L IAH
Sbjct: 604 GSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDW--NSRGDRTVLVIAH 661
Query: 1387 RLHTVLGSDRIMVLAQGQV 1405
RL V + +I+VL +G++
Sbjct: 662 RLQAVQRAHQILVLQEGKL 680
Score = 72.4 bits (176), Expect = 3e-12
Identities = 53/211 (25%), Positives = 107/211 (50%), Gaps = 19/211 (9%)
Query: 578 LHSIDLEIQEGKLVGICGSVGSGKTSLISAIL--------GQMTLLEGSIA------ISG 623
L + ++ G++ + G GSGK S ++A+L GQ+ L E I+ +
Sbjct: 486 LKGLTFTLRPGEVTALVGPNGSGK-STVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHS 544
Query: 624 TFAYVAQQAWILNATLRDNILFG-KEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERG 682
V Q+ + + ++R+NI +G + ++++ + + + + T++GE+G
Sbjct: 545 QVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKG 604
Query: 683 ANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTH 742
+ L+ GQ+QR+++ARAL D + ILD+ SALD + + R +TVL + H
Sbjct: 605 SQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSR---GDRTVLVIAH 661
Query: 743 QLQYLVDCDEVIFMKEGCITERGTHEELMNL 773
+LQ + +++ ++EG + + +E +L
Sbjct: 662 RLQAVQRAHQILVLQEGKLQKLAQLQEGQDL 692
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,511,911
Number of Sequences: 37866
Number of extensions: 2123203
Number of successful extensions: 7476
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 87
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 6759
Number of HSP's gapped (non-prelim): 366
length of query: 1437
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1322
effective length of database: 13,892,928
effective search space: 18366450816
effective search space used: 18366450816
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.