Guide to the Human Genome
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Search of human proteins with 63053524

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|63053524 ubiquitin specific protease 1 [Homo sapiens]
         (785 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|63053524 ubiquitin specific protease 1 [Homo sapiens]             1570   0.0  
gi|63053522 ubiquitin specific protease 1 [Homo sapiens]             1570   0.0  
gi|31543910 ubiquitin specific protease 1 [Homo sapiens]             1570   0.0  
gi|32698815 ubiquitin thiolesterase 12 [Homo sapiens]                  89   2e-17
gi|197116355 ubiquitin specific peptidase 46 isoform 2 [Homo sap...    88   3e-17
gi|31377709 ubiquitin specific peptidase 46 isoform 1 [Homo sapi...    88   3e-17
gi|122937412 ubiquitin specific peptidase 45 [Homo sapiens]            86   1e-16
gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens]     80   6e-15
gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens]    80   6e-15
gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens]    79   2e-14
gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]                   68   4e-11
gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]             67   8e-11
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]             67   8e-11
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]             67   8e-11
gi|79750944 ubiquitin specific peptidase 42 [Homo sapiens]             66   1e-10
gi|109134334 ubiquitin thiolesterase 44 [Homo sapiens]                 66   1e-10
gi|109134332 ubiquitin thiolesterase 44 [Homo sapiens]                 66   1e-10
gi|122114651 ubiquitin specific peptidase 36 [Homo sapiens]            65   2e-10
gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]                 65   2e-10
gi|41152235 ubiquitin specific protease 51 [Homo sapiens]              65   2e-10
gi|76257392 ubiquitin specific protease 48 isoform b [Homo sapiens]    64   4e-10
gi|52630449 ubiquitin specific protease 48 isoform a [Homo sapiens]    64   4e-10
gi|41055953 ubiquitin thioesterase 40 [Homo sapiens]                   64   5e-10
gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]    63   9e-10
gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo sapi...    63   9e-10
gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]         63   1e-09
gi|21361749 ubiquitin thioesterase 49 [Homo sapiens]                   61   4e-09
gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]              60   8e-09
gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]              60   8e-09
gi|239742285 PREDICTED: hypothetical protein XP_002342486 [Homo ...    59   2e-08

>gi|63053524 ubiquitin specific protease 1 [Homo sapiens]
          Length = 785

 Score = 1570 bits (4064), Expect = 0.0
 Identities = 785/785 (100%), Positives = 785/785 (100%)

Query: 1   MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQENEEKASEYRASEIDQV 60
           MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQENEEKASEYRASEIDQV
Sbjct: 1   MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQENEEKASEYRASEIDQV 60

Query: 61  VPAAQSSPINCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKK 120
           VPAAQSSPINCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKK
Sbjct: 61  VPAAQSSPINCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKK 120

Query: 121 EALKDEANQKDKGNCKEDSLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRR 180
           EALKDEANQKDKGNCKEDSLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRR
Sbjct: 121 EALKDEANQKDKGNCKEDSLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRR 180

Query: 181 LLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVAELPTKVEEIPHPK 240
           LLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVAELPTKVEEIPHPK
Sbjct: 181 LLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVAELPTKVEEIPHPK 240

Query: 241 EEMNGINSIEMDSMRHSEDFKEKLPKGNGKRKSDTEFGNMKKKVKLSKEHQSLEENQRQT 300
           EEMNGINSIEMDSMRHSEDFKEKLPKGNGKRKSDTEFGNMKKKVKLSKEHQSLEENQRQT
Sbjct: 241 EEMNGINSIEMDSMRHSEDFKEKLPKGNGKRKSDTEFGNMKKKVKLSKEHQSLEENQRQT 300

Query: 301 RSKRKATSDTLESPPKIIPKYISENESPRPSQKKSRVKINWLKSATKQPSILSKFCSLGK 360
           RSKRKATSDTLESPPKIIPKYISENESPRPSQKKSRVKINWLKSATKQPSILSKFCSLGK
Sbjct: 301 RSKRKATSDTLESPPKIIPKYISENESPRPSQKKSRVKINWLKSATKQPSILSKFCSLGK 360

Query: 361 ITTNQGVKGQSKENECDPEEDLGKCESDNTTNGCGLESPGNTVTPVNVNEVKPINKGEEQ 420
           ITTNQGVKGQSKENECDPEEDLGKCESDNTTNGCGLESPGNTVTPVNVNEVKPINKGEEQ
Sbjct: 361 ITTNQGVKGQSKENECDPEEDLGKCESDNTTNGCGLESPGNTVTPVNVNEVKPINKGEEQ 420

Query: 421 IGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKT 480
           IGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKT
Sbjct: 421 IGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKT 480

Query: 481 EMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGL 540
           EMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGL
Sbjct: 481 EMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGL 540

Query: 541 EFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKV 600
           EFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKV
Sbjct: 541 EFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKV 600

Query: 601 TDLNSLELDKGNFVVDQMCEIGKPEPLNEEEARGVVENYNDEEVSIRVGGNTQPSKVLNK 660
           TDLNSLELDKGNFVVDQMCEIGKPEPLNEEEARGVVENYNDEEVSIRVGGNTQPSKVLNK
Sbjct: 601 TDLNSLELDKGNFVVDQMCEIGKPEPLNEEEARGVVENYNDEEVSIRVGGNTQPSKVLNK 660

Query: 661 KNVEAIGLLGGQKSKADYELYNKASNPDKVASTAFAENRNSETSDTTGTHESDRNKESSD 720
           KNVEAIGLLGGQKSKADYELYNKASNPDKVASTAFAENRNSETSDTTGTHESDRNKESSD
Sbjct: 661 KNVEAIGLLGGQKSKADYELYNKASNPDKVASTAFAENRNSETSDTTGTHESDRNKESSD 720

Query: 721 QTGINISGFENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLL 780
           QTGINISGFENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLL
Sbjct: 721 QTGINISGFENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLL 780

Query: 781 FYKKL 785
           FYKKL
Sbjct: 781 FYKKL 785


>gi|63053522 ubiquitin specific protease 1 [Homo sapiens]
          Length = 785

 Score = 1570 bits (4064), Expect = 0.0
 Identities = 785/785 (100%), Positives = 785/785 (100%)

Query: 1   MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQENEEKASEYRASEIDQV 60
           MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQENEEKASEYRASEIDQV
Sbjct: 1   MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQENEEKASEYRASEIDQV 60

Query: 61  VPAAQSSPINCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKK 120
           VPAAQSSPINCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKK
Sbjct: 61  VPAAQSSPINCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKK 120

Query: 121 EALKDEANQKDKGNCKEDSLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRR 180
           EALKDEANQKDKGNCKEDSLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRR
Sbjct: 121 EALKDEANQKDKGNCKEDSLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRR 180

Query: 181 LLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVAELPTKVEEIPHPK 240
           LLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVAELPTKVEEIPHPK
Sbjct: 181 LLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVAELPTKVEEIPHPK 240

Query: 241 EEMNGINSIEMDSMRHSEDFKEKLPKGNGKRKSDTEFGNMKKKVKLSKEHQSLEENQRQT 300
           EEMNGINSIEMDSMRHSEDFKEKLPKGNGKRKSDTEFGNMKKKVKLSKEHQSLEENQRQT
Sbjct: 241 EEMNGINSIEMDSMRHSEDFKEKLPKGNGKRKSDTEFGNMKKKVKLSKEHQSLEENQRQT 300

Query: 301 RSKRKATSDTLESPPKIIPKYISENESPRPSQKKSRVKINWLKSATKQPSILSKFCSLGK 360
           RSKRKATSDTLESPPKIIPKYISENESPRPSQKKSRVKINWLKSATKQPSILSKFCSLGK
Sbjct: 301 RSKRKATSDTLESPPKIIPKYISENESPRPSQKKSRVKINWLKSATKQPSILSKFCSLGK 360

Query: 361 ITTNQGVKGQSKENECDPEEDLGKCESDNTTNGCGLESPGNTVTPVNVNEVKPINKGEEQ 420
           ITTNQGVKGQSKENECDPEEDLGKCESDNTTNGCGLESPGNTVTPVNVNEVKPINKGEEQ
Sbjct: 361 ITTNQGVKGQSKENECDPEEDLGKCESDNTTNGCGLESPGNTVTPVNVNEVKPINKGEEQ 420

Query: 421 IGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKT 480
           IGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKT
Sbjct: 421 IGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKT 480

Query: 481 EMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGL 540
           EMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGL
Sbjct: 481 EMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGL 540

Query: 541 EFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKV 600
           EFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKV
Sbjct: 541 EFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKV 600

Query: 601 TDLNSLELDKGNFVVDQMCEIGKPEPLNEEEARGVVENYNDEEVSIRVGGNTQPSKVLNK 660
           TDLNSLELDKGNFVVDQMCEIGKPEPLNEEEARGVVENYNDEEVSIRVGGNTQPSKVLNK
Sbjct: 601 TDLNSLELDKGNFVVDQMCEIGKPEPLNEEEARGVVENYNDEEVSIRVGGNTQPSKVLNK 660

Query: 661 KNVEAIGLLGGQKSKADYELYNKASNPDKVASTAFAENRNSETSDTTGTHESDRNKESSD 720
           KNVEAIGLLGGQKSKADYELYNKASNPDKVASTAFAENRNSETSDTTGTHESDRNKESSD
Sbjct: 661 KNVEAIGLLGGQKSKADYELYNKASNPDKVASTAFAENRNSETSDTTGTHESDRNKESSD 720

Query: 721 QTGINISGFENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLL 780
           QTGINISGFENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLL
Sbjct: 721 QTGINISGFENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLL 780

Query: 781 FYKKL 785
           FYKKL
Sbjct: 781 FYKKL 785


>gi|31543910 ubiquitin specific protease 1 [Homo sapiens]
          Length = 785

 Score = 1570 bits (4064), Expect = 0.0
 Identities = 785/785 (100%), Positives = 785/785 (100%)

Query: 1   MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQENEEKASEYRASEIDQV 60
           MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQENEEKASEYRASEIDQV
Sbjct: 1   MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQENEEKASEYRASEIDQV 60

Query: 61  VPAAQSSPINCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKK 120
           VPAAQSSPINCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKK
Sbjct: 61  VPAAQSSPINCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKK 120

Query: 121 EALKDEANQKDKGNCKEDSLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRR 180
           EALKDEANQKDKGNCKEDSLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRR
Sbjct: 121 EALKDEANQKDKGNCKEDSLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRR 180

Query: 181 LLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVAELPTKVEEIPHPK 240
           LLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVAELPTKVEEIPHPK
Sbjct: 181 LLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVAELPTKVEEIPHPK 240

Query: 241 EEMNGINSIEMDSMRHSEDFKEKLPKGNGKRKSDTEFGNMKKKVKLSKEHQSLEENQRQT 300
           EEMNGINSIEMDSMRHSEDFKEKLPKGNGKRKSDTEFGNMKKKVKLSKEHQSLEENQRQT
Sbjct: 241 EEMNGINSIEMDSMRHSEDFKEKLPKGNGKRKSDTEFGNMKKKVKLSKEHQSLEENQRQT 300

Query: 301 RSKRKATSDTLESPPKIIPKYISENESPRPSQKKSRVKINWLKSATKQPSILSKFCSLGK 360
           RSKRKATSDTLESPPKIIPKYISENESPRPSQKKSRVKINWLKSATKQPSILSKFCSLGK
Sbjct: 301 RSKRKATSDTLESPPKIIPKYISENESPRPSQKKSRVKINWLKSATKQPSILSKFCSLGK 360

Query: 361 ITTNQGVKGQSKENECDPEEDLGKCESDNTTNGCGLESPGNTVTPVNVNEVKPINKGEEQ 420
           ITTNQGVKGQSKENECDPEEDLGKCESDNTTNGCGLESPGNTVTPVNVNEVKPINKGEEQ
Sbjct: 361 ITTNQGVKGQSKENECDPEEDLGKCESDNTTNGCGLESPGNTVTPVNVNEVKPINKGEEQ 420

Query: 421 IGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKT 480
           IGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKT
Sbjct: 421 IGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKT 480

Query: 481 EMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGL 540
           EMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGL
Sbjct: 481 EMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGL 540

Query: 541 EFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKV 600
           EFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKV
Sbjct: 541 EFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKV 600

Query: 601 TDLNSLELDKGNFVVDQMCEIGKPEPLNEEEARGVVENYNDEEVSIRVGGNTQPSKVLNK 660
           TDLNSLELDKGNFVVDQMCEIGKPEPLNEEEARGVVENYNDEEVSIRVGGNTQPSKVLNK
Sbjct: 601 TDLNSLELDKGNFVVDQMCEIGKPEPLNEEEARGVVENYNDEEVSIRVGGNTQPSKVLNK 660

Query: 661 KNVEAIGLLGGQKSKADYELYNKASNPDKVASTAFAENRNSETSDTTGTHESDRNKESSD 720
           KNVEAIGLLGGQKSKADYELYNKASNPDKVASTAFAENRNSETSDTTGTHESDRNKESSD
Sbjct: 661 KNVEAIGLLGGQKSKADYELYNKASNPDKVASTAFAENRNSETSDTTGTHESDRNKESSD 720

Query: 721 QTGINISGFENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLL 780
           QTGINISGFENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLL
Sbjct: 721 QTGINISGFENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLL 780

Query: 781 FYKKL 785
           FYKKL
Sbjct: 781 FYKKL 785


>gi|32698815 ubiquitin thiolesterase 12 [Homo sapiens]
          Length = 370

 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 57/179 (31%), Positives = 90/179 (50%), Gaps = 26/179 (14%)

Query: 426 VEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKTEMKTL 485
           V+++FQG L   TRCL CE+++ + EDF D+SV V+++                    ++
Sbjct: 172 VDEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQN-------------------TSI 212

Query: 486 RWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGLEFDCY 545
              +  F++ E +  E KY+CE C    EA + +   K+P ++ +HLK F     +   Y
Sbjct: 213 THCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMD-QLHRY 271

Query: 546 GGGLSKINTPLLTPLKLSLEEWSTKPTNDS--YGLFAVVMHSGITISSGHYTASVKVTD 602
               +K++  ++ PL+L L   S   TN    Y L AVV+H G   + GHY A VK  D
Sbjct: 272 ----TKLSYRVVFPLELRLFNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIVKSHD 326



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 41/146 (28%), Positives = 66/146 (45%), Gaps = 33/146 (22%)

Query: 80  FVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKKEALKDEANQKDKGNCKEDS 139
           + GL N GNTCY NS+LQ LYFC  F+        +++ K +  K E+            
Sbjct: 38  YFGLVNFGNTCYCNSVLQALYFCRPFRE------KVLAYKSQPRKKES------------ 79

Query: 140 LASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGYLQHD 199
                L+  L  L  S+   +    + P          P++ +  LR+ N +++ Y+Q D
Sbjct: 80  -----LLTCLADLFHSIATQKKKVGVIP----------PKKFITRLRKENELFDNYMQQD 124

Query: 200 AQEVLQCILGNIQETCQLLKKEEVKN 225
           A E L  +L  I +  Q  +K+E +N
Sbjct: 125 AHEFLNYLLNTIADILQEERKQEKQN 150


>gi|197116355 ubiquitin specific peptidase 46 isoform 2 [Homo
           sapiens]
          Length = 359

 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 60/195 (30%), Positives = 95/195 (48%), Gaps = 30/195 (15%)

Query: 407 NVNEVKPINKGEEQIGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELS 466
           N+NE    NK E       V ++FQG L   TRCL CE+++ + EDF D+SV V+++   
Sbjct: 146 NMNEPAENNKPE----LTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQN--- 198

Query: 467 KVEESSEISPEPKTEMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPE 526
                            ++   +  F++ E +  E KY+CE C    EA++ +   K+P 
Sbjct: 199 ----------------TSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPM 242

Query: 527 VITIHLKCFAASGLEFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTN--DSYGLFAVVMH 584
           ++ +HLK F     +   Y    +K++  ++ PL+L L   S+   N    Y L AVV+H
Sbjct: 243 ILALHLKRFKYME-QLHRY----TKLSYRVVFPLELRLFNTSSDAVNLDRMYDLVAVVVH 297

Query: 585 SGITISSGHYTASVK 599
            G   + GHY   VK
Sbjct: 298 CGSGPNRGHYITIVK 312



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 46/146 (31%), Positives = 67/146 (45%), Gaps = 33/146 (22%)

Query: 80  FVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKKEALKDEANQKDKGNCKEDS 139
           + GL N GNTCY NS+LQ LYFC  F+  V             L  +A QK K N     
Sbjct: 27  YFGLVNFGNTCYCNSVLQALYFCRPFRENV-------------LAYKAQQKKKEN----- 68

Query: 140 LASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGYLQHD 199
                L+  L  L  S+   +    + P          P++ ++ LR+ N +++ Y+Q D
Sbjct: 69  -----LLTCLADLFHSIATQKKKVGVIP----------PKKFISRLRKENDLFDNYMQQD 113

Query: 200 AQEVLQCILGNIQETCQLLKKEEVKN 225
           A E L  +L  I +  Q  KK+E +N
Sbjct: 114 AHEFLNYLLNTIADILQEEKKQEKQN 139


>gi|31377709 ubiquitin specific peptidase 46 isoform 1 [Homo
           sapiens]
          Length = 366

 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 60/195 (30%), Positives = 95/195 (48%), Gaps = 30/195 (15%)

Query: 407 NVNEVKPINKGEEQIGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELS 466
           N+NE    NK E       V ++FQG L   TRCL CE+++ + EDF D+SV V+++   
Sbjct: 153 NMNEPAENNKPE----LTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQN--- 205

Query: 467 KVEESSEISPEPKTEMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPE 526
                            ++   +  F++ E +  E KY+CE C    EA++ +   K+P 
Sbjct: 206 ----------------TSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPM 249

Query: 527 VITIHLKCFAASGLEFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTN--DSYGLFAVVMH 584
           ++ +HLK F     +   Y    +K++  ++ PL+L L   S+   N    Y L AVV+H
Sbjct: 250 ILALHLKRFKYME-QLHRY----TKLSYRVVFPLELRLFNTSSDAVNLDRMYDLVAVVVH 304

Query: 585 SGITISSGHYTASVK 599
            G   + GHY   VK
Sbjct: 305 CGSGPNRGHYITIVK 319



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 46/146 (31%), Positives = 67/146 (45%), Gaps = 33/146 (22%)

Query: 80  FVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKKEALKDEANQKDKGNCKEDS 139
           + GL N GNTCY NS+LQ LYFC  F+  V             L  +A QK K N     
Sbjct: 34  YFGLVNFGNTCYCNSVLQALYFCRPFRENV-------------LAYKAQQKKKEN----- 75

Query: 140 LASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGYLQHD 199
                L+  L  L  S+   +    + P          P++ ++ LR+ N +++ Y+Q D
Sbjct: 76  -----LLTCLADLFHSIATQKKKVGVIP----------PKKFISRLRKENDLFDNYMQQD 120

Query: 200 AQEVLQCILGNIQETCQLLKKEEVKN 225
           A E L  +L  I +  Q  KK+E +N
Sbjct: 121 AHEFLNYLLNTIADILQEEKKQEKQN 146


>gi|122937412 ubiquitin specific peptidase 45 [Homo sapiens]
          Length = 814

 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 138/602 (22%), Positives = 235/602 (39%), Gaps = 122/602 (20%)

Query: 82  GLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKKEALKDEANQKDKGNCKEDSLA 141
           G+ NLGNTC+ N+++Q L                   +   L D  N+  + + K     
Sbjct: 191 GITNLGNTCFFNAVMQNL------------------AQTYTLTDLMNEIKESSTKLKIFP 232

Query: 142 SYELICSLQSLIISVEQ----LQASFL-LNPEKYTDELATQPRRLLNTLRELNPMYEGYL 196
           S +    L  L++ + +      A FL L+  K T++    P+ L N L +  P ++ + 
Sbjct: 233 SSD--SQLDPLVVELSRPGPLTSALFLFLHSMKETEKGPLSPKVLFNQLCQKAPRFKDFQ 290

Query: 197 QHDAQEVLQCILGNI--QET----CQLLK--KEEVKNVAELPTKVEEIPHPKE--EMNGI 246
           Q D+QE+L  +L  +  +ET      +LK         A+  T+ +   + KE  +MN I
Sbjct: 291 QQDSQELLHYLLDAVRTEETKRIQASILKAFNNPTTKTADDETRKKVKAYGKEGVKMNFI 350

Query: 247 NSIEMDSMRHSEDFKE--------------KLPKGNGKRKSDTEFGNMKKKVKLSK-EHQ 291
           + I +  +  +   +E               LP    +      +G M K   L + +H 
Sbjct: 351 DRIFIGELTSTVMCEECANISTVKDPFIDISLPIIEERVSKPLLWGRMNKYRSLRETDHD 410

Query: 292 SLE-----ENQRQTRSKRKATSDTLESPPKIIPKYISENESPRPSQKKSRVKINWLKSAT 346
                   EN  Q R+ +K +S   +S      K I +  S      +    +     + 
Sbjct: 411 RYSGNVTIENIHQPRAAKKHSSSKDKSQLIHDRKCIRKLSSGETVTYQKNENLEMNGDSL 470

Query: 347 KQPSILSKFCSLGKITTNQGVKGQS-KENECDPEEDLGKCESDNTTNGCGLESPGNTVTP 405
              S+++    L +  T+   K  S  E+  D + +  + ES +   G    S G+ V P
Sbjct: 471 MFASLMNSESRLNESPTDDSEKEASHSESNVDADSEPSESESASKQTGLFRSSSGSGVQP 530

Query: 406 VNVNEVKPINKGE-------EQIGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISV 458
                + P++ G+       +    E+ E + +         L   S     +DF   + 
Sbjct: 531 DG--PLYPLSAGKLLYTKETDSGDKEMAEAISE---------LRLSSTVTGDQDFDRENQ 579

Query: 459 PVQ-EDELSKVEESSEISPEPKTEMKTLRWA-------------ISQFASVERIVGEDKY 504
           P+   + L  +E     S  P+   +TL  +             + QF S+E ++G +K 
Sbjct: 580 PLNISNNLCFLEGKHLRSYSPQNAFQTLSQSYITTSKECSIQSCLYQFTSMELLMGNNKL 639

Query: 505 FCENCHH-------------------YTEAERSLLFDKMPEVITIHLKCFAASGLEFDCY 545
            CENC                     YT A + LL   +P V+ +HLK F  +GL     
Sbjct: 640 LCENCTKNKQKYQEETSFAEKKVEGVYTNARKQLLISAVPAVLILHLKRFHQAGL----- 694

Query: 546 GGGLSKINTPLLTPLKLSLEEWSTKPTNDS-------YGLFAVVMHSGITISSGHYTASV 598
              L K+N  +  PL L L  + +    ++       YGL+ +V HSG ++  GHYTA V
Sbjct: 695 --SLRKVNRHVDFPLMLDLAPFCSATCKNASVGDKVLYGLYGIVEHSG-SMREGHYTAYV 751

Query: 599 KV 600
           KV
Sbjct: 752 KV 753


>gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens]
          Length = 823

 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 159/689 (23%), Positives = 261/689 (37%), Gaps = 167/689 (24%)

Query: 17  PSKKNRLSLKFFQKKETKRALDFTDSQENEEKASEYRASEIDQVVPAAQSSPINCEKREN 76
           P++K+  +++   KK  K +    + QE E+K +            A ++ P+N   +  
Sbjct: 149 PAEKDNGNIELENKKLEKES---KNEQEREKKENM-----------AKENPPMNSPCQ-- 192

Query: 77  LLPFVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKKEALKDEANQKDKGNCK 136
            +   GL+NLGNTC+ N+++Q L   P  +              E LK+          +
Sbjct: 193 -ITVKGLSNLGNTCFFNAVMQNLSQTPVLR--------------ELLKEVKMSGTIVKIE 237

Query: 137 EDSLASYELICSLQSLIISVEQ-----LQASFLLNPEKYTDELATQPRRLLNTLRELNPM 191
              LA  E       L I++E      L  S  LN  + T +    P+ L + + +    
Sbjct: 238 PPDLALTE------PLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVR 291

Query: 192 YEGYLQHDAQEVLQCILGNIQ-ETCQLLKK--------------EEVKNVAELPTKVEEI 236
           ++GY Q D+QE+L+ +L  ++ E  Q + K              EE+KN  +   K + +
Sbjct: 292 FKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSM 351

Query: 237 PHPKEEMNG---INSIEMDSMR-----HSEDFKEKLP---KGNGKRKSDTEFGNMKKKVK 285
           P   + + G    + I  D  R     H       LP     +GK+  + +  N+KK V+
Sbjct: 352 PSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDK--NLKKTVE 409

Query: 286 LSKEHQSLEENQRQTRSKRKATSDTLESPPKIIPKYISENESPRPSQKKSRVKINWLKSA 345
              E Q  EE ++   S  K  SD      K + K     ++ + ++K++       K+ 
Sbjct: 410 --DEDQDSEE-EKDNDSYIKERSDIPSGTSKHLQK-----KAKKQAKKQA-------KNQ 454

Query: 346 TKQPSILSKFCSLGKITTNQGVKGQSKENECDPEEDL----------GKCESDNTTNGCG 395
            +Q  I  K   L  I T    +    E E   + ++          G    +   N   
Sbjct: 455 RRQQKIQGKVLHLNDICTIDHPEDSEYEAEMSLQGEVNIKSNHISQEGVMHKEYCVNQKD 514

Query: 396 LESPGNTVTPVNVNEVKPINKGEEQIGFELVEKLFQGQLVLR--TRCLECESLTERREDF 453
           L      +  V  N+     K  E++  + +      +++    TR L    LTE     
Sbjct: 515 LNGQAKMIESVTDNQ-----KSTEEVDMKNINMDNDLEVLTSSPTRNLNGAYLTEGSNGE 569

Query: 454 QDIS---------VPVQEDELS------------KVEESSEISPEP-----------KTE 481
            DIS           +  DE++            KV E     PE             T+
Sbjct: 570 VDISNGFKNLNLNAALHPDEINIEILNDSHTPGTKVYEVVNEDPETAFCTLANREVFNTD 629

Query: 482 MKTLRWAISQFASVERIVGEDKYFCENC-----------------HHYTEAERSLLFDKM 524
             +++  + QF   E++   +K  CE C                 H YT A++ +L    
Sbjct: 630 ECSIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLA 689

Query: 525 PEVITIHLKCFAASGLEFDCYGGGLSKINTPLLTPLKLSLEEWST--------KPTNDSY 576
           P V+T+HLK F  +G         L K+N  +  P  L L  + T        + T   Y
Sbjct: 690 PPVLTLHLKRFQQAGF-------NLRKVNKHIKFPEILDLAPFCTLKCKNVAEENTRVLY 742

Query: 577 GLFAVVMHSGITISSGHYTASVKVTDLNS 605
            L+ VV HSG T+ SGHYTA  K    NS
Sbjct: 743 SLYGVVEHSG-TMRSGHYTAYAKARTANS 770


>gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens]
          Length = 823

 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 159/689 (23%), Positives = 261/689 (37%), Gaps = 167/689 (24%)

Query: 17  PSKKNRLSLKFFQKKETKRALDFTDSQENEEKASEYRASEIDQVVPAAQSSPINCEKREN 76
           P++K+  +++   KK  K +    + QE E+K +            A ++ P+N   +  
Sbjct: 149 PAEKDNGNIELENKKLEKES---KNEQEREKKENM-----------AKENPPMNSPCQ-- 192

Query: 77  LLPFVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKKEALKDEANQKDKGNCK 136
            +   GL+NLGNTC+ N+++Q L   P  +              E LK+          +
Sbjct: 193 -ITVKGLSNLGNTCFFNAVMQNLSQTPVLR--------------ELLKEVKMSGTIVKIE 237

Query: 137 EDSLASYELICSLQSLIISVEQ-----LQASFLLNPEKYTDELATQPRRLLNTLRELNPM 191
              LA  E       L I++E      L  S  LN  + T +    P+ L + + +    
Sbjct: 238 PPDLALTE------PLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVR 291

Query: 192 YEGYLQHDAQEVLQCILGNIQ-ETCQLLKK--------------EEVKNVAELPTKVEEI 236
           ++GY Q D+QE+L+ +L  ++ E  Q + K              EE+KN  +   K + +
Sbjct: 292 FKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSM 351

Query: 237 PHPKEEMNG---INSIEMDSMR-----HSEDFKEKLP---KGNGKRKSDTEFGNMKKKVK 285
           P   + + G    + I  D  R     H       LP     +GK+  + +  N+KK V+
Sbjct: 352 PSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDK--NLKKTVE 409

Query: 286 LSKEHQSLEENQRQTRSKRKATSDTLESPPKIIPKYISENESPRPSQKKSRVKINWLKSA 345
              E Q  EE ++   S  K  SD      K + K     ++ + ++K++       K+ 
Sbjct: 410 --DEDQDSEE-EKDNDSYIKERSDIPSGTSKHLQK-----KAKKQAKKQA-------KNQ 454

Query: 346 TKQPSILSKFCSLGKITTNQGVKGQSKENECDPEEDL----------GKCESDNTTNGCG 395
            +Q  I  K   L  I T    +    E E   + ++          G    +   N   
Sbjct: 455 RRQQKIQGKVLHLNDICTIDHPEDSEYEAEMSLQGEVNIKSNHISQEGVMHKEYCVNQKD 514

Query: 396 LESPGNTVTPVNVNEVKPINKGEEQIGFELVEKLFQGQLVLR--TRCLECESLTERREDF 453
           L      +  V  N+     K  E++  + +      +++    TR L    LTE     
Sbjct: 515 LNGQAKMIESVTDNQ-----KSTEEVDMKNINMDNDLEVLTSSPTRNLNGAYLTEGSNGE 569

Query: 454 QDIS---------VPVQEDELS------------KVEESSEISPEP-----------KTE 481
            DIS           +  DE++            KV E     PE             T+
Sbjct: 570 VDISNGFKNLNLNAALHPDEINIEILNDSHTPGTKVYEVVNEDPETAFCTLANREVFNTD 629

Query: 482 MKTLRWAISQFASVERIVGEDKYFCENC-----------------HHYTEAERSLLFDKM 524
             +++  + QF   E++   +K  CE C                 H YT A++ +L    
Sbjct: 630 ECSIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLA 689

Query: 525 PEVITIHLKCFAASGLEFDCYGGGLSKINTPLLTPLKLSLEEWST--------KPTNDSY 576
           P V+T+HLK F  +G         L K+N  +  P  L L  + T        + T   Y
Sbjct: 690 PPVLTLHLKRFQQAGF-------NLRKVNKHIKFPEILDLAPFCTLKCKNVAEENTRVLY 742

Query: 577 GLFAVVMHSGITISSGHYTASVKVTDLNS 605
            L+ VV HSG T+ SGHYTA  K    NS
Sbjct: 743 SLYGVVEHSG-TMRSGHYTAYAKARTANS 770


>gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens]
          Length = 822

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 154/662 (23%), Positives = 249/662 (37%), Gaps = 156/662 (23%)

Query: 44  ENEEKASEYRASEIDQVVPAAQSSPINCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCP 103
           E E K  + R  + +    A ++ P+N   +   +   GL+NLGNTC+ N+++Q L   P
Sbjct: 164 EKESKNEQEREKKENM---AKENPPMNSPCQ---ITVKGLSNLGNTCFFNAVMQNLSQTP 217

Query: 104 GFKSGVKHLFNIISRKKEALKDEANQKDKGNCKEDSLASYELICSLQSLIISVEQ----- 158
             +              E LK+          +   LA  E       L I++E      
Sbjct: 218 VLR--------------ELLKEVKMSGTIVKIEPPDLALTE------PLEINLEPPGPLT 257

Query: 159 LQASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGYLQHDAQEVLQCILGNIQ-ETCQL 217
           L  S  LN  + T +    P+ L + + +    ++GY Q D+QE+L+ +L  ++ E  Q 
Sbjct: 258 LAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQR 317

Query: 218 LKK--------------EEVKNVAELPTKVEEIPHPKEEMNG---INSIEMDSMR----- 255
           + K              EE+KN  +   K + +P   + + G    + I  D  R     
Sbjct: 318 VSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTSMIMCDQCRTVSLV 377

Query: 256 HSEDFKEKLP---KGNGKRKSDTEFGNMKKKVKLSKEHQSLEENQRQTRSKRKATSDTLE 312
           H       LP     +GK+  + +  N+KK V+   E Q  EE ++   S  K  SD   
Sbjct: 378 HESFLDLSLPVLDDQSGKKSVNDK--NLKKTVE--DEDQDSEE-EKDNDSYIKERSDIPS 432

Query: 313 SPPKIIPKYISENESPRPSQKKSRVKINWLKSATKQPSILSKFCSLGKITTNQGVKGQSK 372
              K + K     ++ + ++K++       K+  +Q  I  K   L  I T    +    
Sbjct: 433 GTSKHLQK-----KAKKQAKKQA-------KNQRRQQKIQGKVLHLNDICTIDHPEDSEY 480

Query: 373 ENECDPEEDL----------GKCESDNTTNGCGLESPGNTVTPVNVNEVKPINKGEEQIG 422
           E E   + ++          G    +   N   L      +  V  N+     K  E++ 
Sbjct: 481 EAEMSLQGEVNIKSNHISQEGVMHKEYCVNQKDLNGQAKMIESVTDNQ-----KSTEEVD 535

Query: 423 FELVEKLFQGQLVLR--TRCLECESLTERREDFQDIS---------VPVQEDELS----- 466
            + +      +++    TR L    LTE      DIS           +  DE++     
Sbjct: 536 MKNINMDNDLEVLTSSPTRNLNGAYLTEGSNGEVDISNGFKNLNLNAALHPDEINIEILN 595

Query: 467 -------KVEESSEISPEP-----------KTEMKTLRWAISQFASVERIVGEDKYFCEN 508
                  KV E     PE             T+  +++  + QF   E++   +K  CE 
Sbjct: 596 DSHTPGTKVYEVVNEDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEV 655

Query: 509 C-----------------HHYTEAERSLLFDKMPEVITIHLKCFAASGLEFDCYGGGLSK 551
           C                 H YT A++ +L    P V+T+HLK F  +G         L K
Sbjct: 656 CTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGF-------NLRK 708

Query: 552 INTPLLTPLKLSLEEWST--------KPTNDSYGLFAVVMHSGITISSGHYTASVKVTDL 603
           +N  +  P  L L  + T        + T   Y L+ VV HSG T+ SGHYTA  K    
Sbjct: 709 VNKHIKFPEILDLAPFCTLKCKNVAEENTRVLYSLYGVVEHSG-TMRSGHYTAYAKARTA 767

Query: 604 NS 605
           NS
Sbjct: 768 NS 769



 Score = 38.5 bits (88), Expect = 0.024
 Identities = 58/276 (21%), Positives = 105/276 (38%), Gaps = 28/276 (10%)

Query: 216 QLLKKEEVKNVAELPTKVEEIPHPKEEMNGIN------SIEMDSMRHSE-DFKEKLPKGN 268
           Q     ++  V +   K   I  PK E +  N       +E +S    E + KE + K N
Sbjct: 124 QYCSSNQLGQVVDYVRKQASITTPKPEKDNGNIELENKKLEKESKNEQEREKKENMAKEN 183

Query: 269 GKRKSDTEF-----GNMKKKVKLSKEHQSLEEN----QRQTRSKRKATSDTLESPPKIIP 319
               S  +       N+      +   Q+L +     +     K   T   +E P   + 
Sbjct: 184 PPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALT 243

Query: 320 KYISEN-ESPRPSQKKSRVKINWLKSATK----QPSILSKFCSLGKITTNQGVKGQSKEN 374
           + +  N E P P        +N ++   K       + S+ C   K    +G + Q  + 
Sbjct: 244 EPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCK--KAVRFKGYQQQDSQE 301

Query: 375 ECDPEEDLGKCESDNTTNGCGLESPGNTVTPVNV---NEVKPINKGEEQIGFELVEKLFQ 431
                 D  + E     +   L++ GN+   ++    N+VK   K +    F  V+++F 
Sbjct: 302 LLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSF--VDRIFG 359

Query: 432 GQLVLRTRCLECESLTERREDFQDISVPVQEDELSK 467
           G+L     C +C +++   E F D+S+PV +D+  K
Sbjct: 360 GELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGK 395


>gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]
          Length = 520

 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 49/178 (27%), Positives = 84/178 (47%), Gaps = 18/178 (10%)

Query: 425 LVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKTEMKT 484
           +V  +F G L     CL C + + + + F D+S+ +     SK  ++ E  P     + +
Sbjct: 309 VVTAIFGGILQNEVNCLICGTESRKFDPFLDLSLDIPSQFRSKRSKNQENGP-----VCS 363

Query: 485 LRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGLEFDC 544
           LR  +  F  +E +   + Y C  C    ++ +     K+P+V+ +HLK F      +  
Sbjct: 364 LRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRF-----HWTA 418

Query: 545 YGGGLSKINTPLLTPLK------LSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTA 596
           Y    +K++T +  PL+        LE  ++ P +  Y L AVV+H G  + SGHYTA
Sbjct: 419 Y--LRNKVDTYVEFPLRGLDMKCYLLEPENSGPESCLYDLAAVVVHHGSGVGSGHYTA 474



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 33/132 (25%), Positives = 57/132 (43%), Gaps = 21/132 (15%)

Query: 82  GLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRK-KEALKDEANQKDKGNCKEDSL 140
           GL NLGNTC++N+ILQ L     F    K L  +  R  K A +   + + +G+     +
Sbjct: 160 GLRNLGNTCFMNAILQSLSNIEQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDNNVSLV 219

Query: 141 ASY-ELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGYLQHD 199
             + + +C+L                       + A  P  L   + ++ P + GY Q D
Sbjct: 220 EEFRKTLCALWQ-------------------GSQTAFSPESLFYVVWKIMPNFRGYQQQD 260

Query: 200 AQEVLQCILGNI 211
           A E ++ +L ++
Sbjct: 261 AHEFMRYLLDHL 272


>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 48/184 (26%), Positives = 83/184 (45%), Gaps = 28/184 (15%)

Query: 419  EQIGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEP 478
            +Q+   ++  LFQGQ     +CL C   +   E F  +S+P+                  
Sbjct: 915  KQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLAS---------------- 958

Query: 479  KTEMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAAS 538
             T   TL+  +  F+  E++   ++++C +C    ++ + +   K+P V+ +HLK F+  
Sbjct: 959  -TSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYD 1017

Query: 539  GLEFDCYGGGLSKINTPLLTPLK-LSLEEWSTKPTND--SYGLFAVVMHSGITISSGHYT 595
                   G    K+ T +  PL+ L L ++   P N+   Y LF+V  H G  +  GHYT
Sbjct: 1018 -------GRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYG-GLDGGHYT 1069

Query: 596  ASVK 599
            A  K
Sbjct: 1070 AYCK 1073



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 47/184 (25%), Positives = 77/184 (41%), Gaps = 28/184 (15%)

Query: 30  KKETKRALDFTDSQENEEKASEYRASEIDQVVPAAQSSPINCEKRENLLPFVGLNNLGNT 89
           ++E KR    T +   E K + Y  +EI ++  A+Q   +N     +     GL NLGNT
Sbjct: 727 QEEEKRKPTVTPTVNRENKPTCYPKAEISRL-SASQIRNLNPVFGGSGPALTGLRNLGNT 785

Query: 90  CYLNSILQVLYFCPGFKSGVKHLFNIISRKKEALKDEANQKDKGNCKEDSLASYELICSL 149
           CY+NSILQ L   P       HL +  +R               NC +D +    L+   
Sbjct: 786 CYMNSILQCLCNAP-------HLADYFNR---------------NCYQDDINRSNLLGHK 823

Query: 150 QSLIISVEQLQASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGYLQHDAQEVLQCILG 209
             +      +  +      +Y       P+    T+ ++N  + GY Q D+QE+L  ++ 
Sbjct: 824 GEVAEEFGIIMKALWTGQYRY-----ISPKDFKITIGKINDQFAGYSQQDSQELLLFLMD 878

Query: 210 NIQE 213
            + E
Sbjct: 879 GLHE 882


>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 48/184 (26%), Positives = 83/184 (45%), Gaps = 28/184 (15%)

Query: 419  EQIGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEP 478
            +Q+   ++  LFQGQ     +CL C   +   E F  +S+P+                  
Sbjct: 915  KQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLAS---------------- 958

Query: 479  KTEMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAAS 538
             T   TL+  +  F+  E++   ++++C +C    ++ + +   K+P V+ +HLK F+  
Sbjct: 959  -TSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYD 1017

Query: 539  GLEFDCYGGGLSKINTPLLTPLK-LSLEEWSTKPTND--SYGLFAVVMHSGITISSGHYT 595
                   G    K+ T +  PL+ L L ++   P N+   Y LF+V  H G  +  GHYT
Sbjct: 1018 -------GRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYG-GLDGGHYT 1069

Query: 596  ASVK 599
            A  K
Sbjct: 1070 AYCK 1073



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 47/184 (25%), Positives = 77/184 (41%), Gaps = 28/184 (15%)

Query: 30  KKETKRALDFTDSQENEEKASEYRASEIDQVVPAAQSSPINCEKRENLLPFVGLNNLGNT 89
           ++E KR    T +   E K + Y  +EI ++  A+Q   +N     +     GL NLGNT
Sbjct: 727 QEEEKRKPTVTPTVNRENKPTCYPKAEISRL-SASQIRNLNPVFGGSGPALTGLRNLGNT 785

Query: 90  CYLNSILQVLYFCPGFKSGVKHLFNIISRKKEALKDEANQKDKGNCKEDSLASYELICSL 149
           CY+NSILQ L   P       HL +  +R               NC +D +    L+   
Sbjct: 786 CYMNSILQCLCNAP-------HLADYFNR---------------NCYQDDINRSNLLGHK 823

Query: 150 QSLIISVEQLQASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGYLQHDAQEVLQCILG 209
             +      +  +      +Y       P+    T+ ++N  + GY Q D+QE+L  ++ 
Sbjct: 824 GEVAEEFGIIMKALWTGQYRY-----ISPKDFKITIGKINDQFAGYSQQDSQELLLFLMD 878

Query: 210 NIQE 213
            + E
Sbjct: 879 GLHE 882


>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
          Length = 1118

 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 48/184 (26%), Positives = 83/184 (45%), Gaps = 28/184 (15%)

Query: 419  EQIGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEP 478
            +Q+   ++  LFQGQ     +CL C   +   E F  +S+P+                  
Sbjct: 915  KQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLAS---------------- 958

Query: 479  KTEMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAAS 538
             T   TL+  +  F+  E++   ++++C +C    ++ + +   K+P V+ +HLK F+  
Sbjct: 959  -TSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYD 1017

Query: 539  GLEFDCYGGGLSKINTPLLTPLK-LSLEEWSTKPTND--SYGLFAVVMHSGITISSGHYT 595
                   G    K+ T +  PL+ L L ++   P N+   Y LF+V  H G  +  GHYT
Sbjct: 1018 -------GRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYG-GLDGGHYT 1069

Query: 596  ASVK 599
            A  K
Sbjct: 1070 AYCK 1073



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 47/184 (25%), Positives = 77/184 (41%), Gaps = 28/184 (15%)

Query: 30  KKETKRALDFTDSQENEEKASEYRASEIDQVVPAAQSSPINCEKRENLLPFVGLNNLGNT 89
           ++E KR    T +   E K + Y  +EI ++  A+Q   +N     +     GL NLGNT
Sbjct: 727 QEEEKRKPTVTPTVNRENKPTCYPKAEISRL-SASQIRNLNPVFGGSGPALTGLRNLGNT 785

Query: 90  CYLNSILQVLYFCPGFKSGVKHLFNIISRKKEALKDEANQKDKGNCKEDSLASYELICSL 149
           CY+NSILQ L   P       HL +  +R               NC +D +    L+   
Sbjct: 786 CYMNSILQCLCNAP-------HLADYFNR---------------NCYQDDINRSNLLGHK 823

Query: 150 QSLIISVEQLQASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGYLQHDAQEVLQCILG 209
             +      +  +      +Y       P+    T+ ++N  + GY Q D+QE+L  ++ 
Sbjct: 824 GEVAEEFGIIMKALWTGQYRY-----ISPKDFKITIGKINDQFAGYSQQDSQELLLFLMD 878

Query: 210 NIQE 213
            + E
Sbjct: 879 GLHE 882


>gi|79750944 ubiquitin specific peptidase 42 [Homo sapiens]
          Length = 1316

 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 44/180 (24%), Positives = 83/180 (46%), Gaps = 30/180 (16%)

Query: 425 LVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKTEMKT 484
           LV ++F G L  R +CL C+ +++  + + DI++ ++  +                   +
Sbjct: 229 LVCQIFGGYLRSRVKCLNCKGVSDTFDPYLDITLEIKAAQ-------------------S 269

Query: 485 LRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGLEFDC 544
           +  A+ QF   E++ GE+ Y C  C     A +     +   V+T+ LK FA        
Sbjct: 270 VNKALEQFVKPEQLDGENSYKCSKCKKMVPASKRFTIHRSSNVLTLSLKRFAN------- 322

Query: 545 YGGGLSKINTPLLTPLKLSLEEWSTKPTNDS--YGLFAVVMHSGITISSGHYTASVKVTD 602
           + GG  KI   +  P  L +  + ++P  +   Y L+AV++H+G    +GHY   +K ++
Sbjct: 323 FTGG--KIAKDVKYPEYLDIRPYMSQPNGEPIVYVLYAVLVHTGFNCHAGHYFCYIKASN 380



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 35/134 (26%), Positives = 56/134 (41%), Gaps = 32/134 (23%)

Query: 82  GLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKKEALKDEANQKDKGNCKEDSLA 141
           GL NLGNTC+ N+ LQ L + P        L N +   + +    A    +G C      
Sbjct: 112 GLQNLGNTCFANAALQCLTYTP-------PLANYMLSHEHSKTCHA----EGFC------ 154

Query: 142 SYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGYLQHDAQ 201
              ++C++Q+ I          L NP         +P  ++N +R +   +    Q DA 
Sbjct: 155 ---MMCTMQAHITQA-------LSNPGD-----VIKPMFVINEMRRIARHFRFGNQEDAH 199

Query: 202 EVLQCILGNIQETC 215
           E LQ  +  +Q+ C
Sbjct: 200 EFLQYTVDAMQKAC 213


>gi|109134334 ubiquitin thiolesterase 44 [Homo sapiens]
          Length = 712

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 56/192 (29%), Positives = 87/192 (45%), Gaps = 36/192 (18%)

Query: 425 LVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEP--KTEM 482
           +V  +F GQL+ +  CL C++ +   E F D+S+   E          +I+ +P   TEM
Sbjct: 464 VVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYQCS---GKDIASQPCLVTEM 520

Query: 483 KTLRWAISQFASVERIVGEDKYFCENCHH-----------YTEAERSLLFDKMPEVITIH 531
                 +++F   E + G+  Y C+ C+             TEA++ L+   +P+V+ +H
Sbjct: 521 ------LAKFTETEALEGKI-YVCDQCNSKRRRFSSKPVVLTEAQKQLMICHLPQVLRLH 573

Query: 532 LKCFAASGLEFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDS-------YGLFAVVMH 584
           LK F  SG           KI   +     L++E +  + T  S       Y L AVVMH
Sbjct: 574 LKRFRWSGRN------NREKIGVHVGFEEILNMEPYCCRETLKSLRPECFIYDLSAVVMH 627

Query: 585 SGITISSGHYTA 596
            G    SGHYTA
Sbjct: 628 HGKGFGSGHYTA 639



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 65/254 (25%), Positives = 103/254 (40%), Gaps = 65/254 (25%)

Query: 40  TDSQENEEKASEYRASEIDQVVPAAQSSPINCEKRENLLPFV-GLNNLGNTCYLNSILQV 98
           T +   ++K      +EI Q V     S  + ++R  + P V GL NLGNTCY+NS+LQV
Sbjct: 236 TPASPAKDKVLSTSENEISQKV-----SDSSVKRRPIVTPGVTGLRNLGNTCYMNSVLQV 290

Query: 99  LYFCPGFKSGV------KHLFNIISRKKEALK------------DEANQKDKGNCKEDSL 140
           L     F+         + L    S K  + K            +E  +KD G       
Sbjct: 291 LSHLLIFRQCFLKLDLNQWLAMTASEKTRSCKHPPVTDTVVYQMNECQEKDTG------- 343

Query: 141 ASYELICSLQSLIIS-----VEQLQASFLLNPEKYTDELAT------------------- 176
                +CS QS + S       + +   L+ P++ T +  +                   
Sbjct: 344 ----FVCSRQSSLSSGLSGGASKGRKMELIQPKEPTSQYISLCHELHTLFQVMWSGKWAL 399

Query: 177 -QPRRLLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVAELPTKVEE 235
             P  +L+++  L P + GY Q DAQE L  +L  IQ     L+       A +PT   +
Sbjct: 400 VSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQRE---LETTGTSLPALIPTSQRK 456

Query: 236 IPHPKEEMNGINSI 249
           +   K+ +N +N+I
Sbjct: 457 L--IKQVLNVVNNI 468


>gi|109134332 ubiquitin thiolesterase 44 [Homo sapiens]
          Length = 712

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 56/192 (29%), Positives = 87/192 (45%), Gaps = 36/192 (18%)

Query: 425 LVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEP--KTEM 482
           +V  +F GQL+ +  CL C++ +   E F D+S+   E          +I+ +P   TEM
Sbjct: 464 VVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYQCS---GKDIASQPCLVTEM 520

Query: 483 KTLRWAISQFASVERIVGEDKYFCENCHH-----------YTEAERSLLFDKMPEVITIH 531
                 +++F   E + G+  Y C+ C+             TEA++ L+   +P+V+ +H
Sbjct: 521 ------LAKFTETEALEGKI-YVCDQCNSKRRRFSSKPVVLTEAQKQLMICHLPQVLRLH 573

Query: 532 LKCFAASGLEFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDS-------YGLFAVVMH 584
           LK F  SG           KI   +     L++E +  + T  S       Y L AVVMH
Sbjct: 574 LKRFRWSGRN------NREKIGVHVGFEEILNMEPYCCRETLKSLRPECFIYDLSAVVMH 627

Query: 585 SGITISSGHYTA 596
            G    SGHYTA
Sbjct: 628 HGKGFGSGHYTA 639



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 65/254 (25%), Positives = 103/254 (40%), Gaps = 65/254 (25%)

Query: 40  TDSQENEEKASEYRASEIDQVVPAAQSSPINCEKRENLLPFV-GLNNLGNTCYLNSILQV 98
           T +   ++K      +EI Q V     S  + ++R  + P V GL NLGNTCY+NS+LQV
Sbjct: 236 TPASPAKDKVLSTSENEISQKV-----SDSSVKRRPIVTPGVTGLRNLGNTCYMNSVLQV 290

Query: 99  LYFCPGFKSGV------KHLFNIISRKKEALK------------DEANQKDKGNCKEDSL 140
           L     F+         + L    S K  + K            +E  +KD G       
Sbjct: 291 LSHLLIFRQCFLKLDLNQWLAMTASEKTRSCKHPPVTDTVVYQMNECQEKDTG------- 343

Query: 141 ASYELICSLQSLIIS-----VEQLQASFLLNPEKYTDELAT------------------- 176
                +CS QS + S       + +   L+ P++ T +  +                   
Sbjct: 344 ----FVCSRQSSLSSGLSGGASKGRKMELIQPKEPTSQYISLCHELHTLFQVMWSGKWAL 399

Query: 177 -QPRRLLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVAELPTKVEE 235
             P  +L+++  L P + GY Q DAQE L  +L  IQ     L+       A +PT   +
Sbjct: 400 VSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQRE---LETTGTSLPALIPTSQRK 456

Query: 236 IPHPKEEMNGINSI 249
           +   K+ +N +N+I
Sbjct: 457 L--IKQVLNVVNNI 468


>gi|122114651 ubiquitin specific peptidase 36 [Homo sapiens]
          Length = 1123

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 44/180 (24%), Positives = 82/180 (45%), Gaps = 30/180 (16%)

Query: 425 LVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKTEMKT 484
           LV ++F G L  R +C  C+S+++  + + D+++ +++                      
Sbjct: 240 LVHQIFGGYLRSRVKCSVCKSVSDTYDPYLDVALEIRQ-------------------AAN 280

Query: 485 LRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGLEFDC 544
           +  A+  F   + + GE+ Y C  C     A +     +   V+T+ LK FA        
Sbjct: 281 IVRALELFVKADVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRFAN------- 333

Query: 545 YGGGLSKINTPLLTPLKLSLEEWSTKPTNDS--YGLFAVVMHSGITISSGHYTASVKVTD 602
           + GG  KI   +  P  L++  + ++   D   YGL+AV++HSG +  +GHY   VK ++
Sbjct: 334 FSGG--KITKDVGYPEFLNIRPYMSQNNGDPVMYGLYAVLVHSGYSCHAGHYYCYVKASN 391



 Score = 37.4 bits (85), Expect = 0.054
 Identities = 32/134 (23%), Positives = 58/134 (43%), Gaps = 32/134 (23%)

Query: 82  GLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKKEALKDEANQKDKGNCKEDSLA 141
           GL+NLGNTC+LN+ +Q L + P        L N +  K+ A           +C +    
Sbjct: 123 GLHNLGNTCFLNATIQCLTYTP-------PLANYLLSKEHA----------RSCHQ---G 162

Query: 142 SYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGYLQHDAQ 201
           S+ ++C +Q+ I+       +            A +P   +  L+++   +    Q DA 
Sbjct: 163 SFCMLCVMQNHIVQAFANSGN------------AIKPVSFIRDLKKIARHFRFGNQEDAH 210

Query: 202 EVLQCILGNIQETC 215
           E L+  +  +Q+ C
Sbjct: 211 EFLRYTIDAMQKAC 224


>gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]
          Length = 525

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 54/198 (27%), Positives = 84/198 (42%), Gaps = 31/198 (15%)

Query: 425 LVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDE-----LSKVEESSEISPEPK 479
           +++++F G L     C  C  ++   + F DIS+ +         LS   E + ++ E  
Sbjct: 296 IIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPGSSTPFWPLSPGSEGNVVNGESH 355

Query: 480 TE-MKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAAS 538
                TL   + +F   E +    K  C  CH Y E+ + L   K+P V   HLK F  S
Sbjct: 356 VSGTTTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRFEHS 415

Query: 539 GLEFDCYGGGLSKINTPLLTPLKLSLEEWST------------KPT-----NDSYGLFAV 581
                       KI T +  PL+L +  +              +PT     ++ Y LFAV
Sbjct: 416 AKL-------RRKITTYVSFPLELDMTPFMASSKESRMNGQYQQPTDSLNNDNKYSLFAV 468

Query: 582 VMHSGITISSGHYTASVK 599
           V H G T+ SGHYT+ ++
Sbjct: 469 VNHQG-TLESGHYTSFIR 485



 Score = 34.3 bits (77), Expect = 0.46
 Identities = 36/136 (26%), Positives = 52/136 (38%), Gaps = 34/136 (25%)

Query: 82  GLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKKEALKDEANQKDKGNCKEDSLA 141
           GL NLGNTC++N I+Q L   P                   L  +    D+  C+  S +
Sbjct: 177 GLINLGNTCFMNCIVQALTHTP-------------------LLRDFFLSDRHRCEMQSPS 217

Query: 142 SYELICSLQSLIISVEQLQASFLLNPEKYTDELATQ-PRRLLNTLRELNPMYEGYLQHDA 200
           S  L+C + SL               E Y+   +   P +LL+ +        GY Q DA
Sbjct: 218 SC-LVCEMSSLF-------------QEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQDA 263

Query: 201 QEVLQCILGNIQETCQ 216
            E L   L  +   C+
Sbjct: 264 HEFLIAALDVLHRHCK 279


>gi|41152235 ubiquitin specific protease 51 [Homo sapiens]
          Length = 711

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 53/197 (26%), Positives = 85/197 (43%), Gaps = 30/197 (15%)

Query: 425 LVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQE-----DELSKVEESSEISPEPK 479
           +++++F G L     C  C S++   +   DIS+ +       D  +     S +S +  
Sbjct: 483 IIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLDLPGSCATFDSQNPERADSTVSRDDH 542

Query: 480 TE-MKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAAS 538
              + +L   +  F   E +    K  C +C  Y E+ + L   K+P V   HLK     
Sbjct: 543 IPGIPSLTDCLQWFTRPEHLGSSAKIKCNSCQSYQESTKQLTMKKLPIVACFHLK----- 597

Query: 539 GLEFDCYGGGLSKINTPLLTPLKLSLEEW--STK--------------PTNDSYGLFAVV 582
              F+  G    KINT +  PL+L +  +  STK              P  + Y LFAV+
Sbjct: 598 --RFEHVGKQRRKINTFISFPLELDMTPFLASTKESRMKEGQPPTDCVPNENKYSLFAVI 655

Query: 583 MHSGITISSGHYTASVK 599
            H G T+ SGHYT+ ++
Sbjct: 656 NHHG-TLESGHYTSFIR 671



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 14/25 (56%), Positives = 17/25 (68%)

Query: 82  GLNNLGNTCYLNSILQVLYFCPGFK 106
           GL NLGNTC++N I+Q L   P  K
Sbjct: 364 GLINLGNTCFMNCIVQALTHIPLLK 388


>gi|76257392 ubiquitin specific protease 48 isoform b [Homo sapiens]
          Length = 485

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 48/176 (27%), Positives = 78/176 (44%), Gaps = 25/176 (14%)

Query: 425 LVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKTEMKT 484
           +V++ F G+    T C +C   ++    F ++ + +Q                     K 
Sbjct: 208 IVQQQFCGEYAYVTVCNQCGRESKLLSKFYELELNIQGH-------------------KQ 248

Query: 485 LRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGLEFDC 544
           L   IS+F   E++ G+++YFCENC     A R +    +P  + + L  F      FD 
Sbjct: 249 LTDCISEFLKEEKLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFV-----FDR 303

Query: 545 YGGGLSKINTPLLTPLKLSLEEW-STKPTNDSYGLFAVVMHSGITISSGHYTASVK 599
             G   K+NT +     L +E +   K  +  Y L AV++H G++  SGHY A VK
Sbjct: 304 QTGHKKKLNTYIGFSEILDMEPYVEHKGGSYVYELSAVLIHRGVSAYSGHYIAHVK 359



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 41/171 (23%), Positives = 66/171 (38%), Gaps = 51/171 (29%)

Query: 70  NCEKRENLLPFVGLNNLGNTCYLNSILQV----------LYFCPGFKSGVKHLFNIISRK 119
           NCE+R+    FVGL NLG TCY+N+ LQV          LY CP             S  
Sbjct: 79  NCERRKKN-SFVGLTNLGATCYVNTFLQVWFLNLELRQALYLCP-------------STC 124

Query: 120 KEALKDEANQKDKGNCKEDSLASYE--LICSLQSLIISVEQLQASFLLNPEKYTDELATQ 177
            + +  +  Q++K          YE   IC     + ++ Q      ++P  +   L   
Sbjct: 125 SDYMLGDGIQEEK---------DYEPQTICEHLQYLFALLQNSNRRYIDPSGFVKALGLD 175

Query: 178 PRRLLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVAE 228
             +                Q DAQE  +  +  +++T    K  +V+N+ +
Sbjct: 176 TGQ----------------QQDAQEFSKLFMSLLEDTLSKQKNPDVRNIVQ 210


>gi|52630449 ubiquitin specific protease 48 isoform a [Homo sapiens]
          Length = 1035

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 48/176 (27%), Positives = 78/176 (44%), Gaps = 25/176 (14%)

Query: 425 LVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKTEMKT 484
           +V++ F G+    T C +C   ++    F ++ + +Q                     K 
Sbjct: 208 IVQQQFCGEYAYVTVCNQCGRESKLLSKFYELELNIQGH-------------------KQ 248

Query: 485 LRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGLEFDC 544
           L   IS+F   E++ G+++YFCENC     A R +    +P  + + L  F      FD 
Sbjct: 249 LTDCISEFLKEEKLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFV-----FDR 303

Query: 545 YGGGLSKINTPLLTPLKLSLEEW-STKPTNDSYGLFAVVMHSGITISSGHYTASVK 599
             G   K+NT +     L +E +   K  +  Y L AV++H G++  SGHY A VK
Sbjct: 304 QTGHKKKLNTYIGFSEILDMEPYVEHKGGSYVYELSAVLIHRGVSAYSGHYIAHVK 359



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 41/171 (23%), Positives = 66/171 (38%), Gaps = 51/171 (29%)

Query: 70  NCEKRENLLPFVGLNNLGNTCYLNSILQV----------LYFCPGFKSGVKHLFNIISRK 119
           NCE+R+    FVGL NLG TCY+N+ LQV          LY CP             S  
Sbjct: 79  NCERRKKN-SFVGLTNLGATCYVNTFLQVWFLNLELRQALYLCP-------------STC 124

Query: 120 KEALKDEANQKDKGNCKEDSLASYE--LICSLQSLIISVEQLQASFLLNPEKYTDELATQ 177
            + +  +  Q++K          YE   IC     + ++ Q      ++P  +   L   
Sbjct: 125 SDYMLGDGIQEEK---------DYEPQTICEHLQYLFALLQNSNRRYIDPSGFVKALGLD 175

Query: 178 PRRLLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVAE 228
             +                Q DAQE  +  +  +++T    K  +V+N+ +
Sbjct: 176 TGQ----------------QQDAQEFSKLFMSLLEDTLSKQKNPDVRNIVQ 210


>gi|41055953 ubiquitin thioesterase 40 [Homo sapiens]
          Length = 1247

 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 86/379 (22%), Positives = 159/379 (41%), Gaps = 67/379 (17%)

Query: 422 GFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKTE 481
           G +L+ +L+ G +V +  C EC++++ER+EDF D++V V+   +S +E++          
Sbjct: 166 GHDLIYRLYHGTIVNQIVCKECKNVSERQEDFLDLTVAVK--NVSGLEDA---------- 213

Query: 482 MKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGLE 541
                W  + +   E    ++ Y C  C    +A +S    K+P  +T+ L  F    ++
Sbjct: 214 ----LW--NMYVEEEVFDCDNLYHCGTCDRLVKAAKSAKLRKLPPFLTVSLLRFNFDFVK 267

Query: 542 FDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDS----YGLFAVVMHSGITISSGHYTAS 597
            + Y     K  +    PL+++L+ +  +   D     Y LF+V++H G     GHY   
Sbjct: 268 CERY-----KETSCYTFPLRINLKPFCEQSELDDLEYIYDLFSVIIHKG-GCYGGHYHVY 321

Query: 598 VKVTDLNSLELDKGNFVVDQMCEIGKPEPLNEEEARGVVENYNDEEVSIRVG-----GNT 652
           +K  D        GN+   +  E  KP+ +N ++ +   E   D  + I         N 
Sbjct: 322 IKDVD------HLGNWQFQE--EKSKPD-VNLKDLQS--EEEIDHPLMILKAILLEENNL 370

Query: 653 QPSKVLNKKNVEAIGLLGGQKSKADYELYNKASNPDKVASTAFAENRNSETSD--TTGTH 710
            P   L +K ++ IG+   +K +  +    K     ++ S  F  + +  T       + 
Sbjct: 371 IPVDQLGQKLLKKIGISWNKKYRKQHGPLRKFL---QLHSQIFLLSSDESTVRLLKNSSL 427

Query: 711 ESDRNKESSDQTGINI-----SGFENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLN 765
           +++ + + +DQ    +      G  N IS            W   +DS+V+   EKD   
Sbjct: 428 QAESDFQRNDQQIFKMLPPESPGLNNSISC---------PHWFDINDSKVQPIREKDIEQ 478

Query: 766 SLSPSTSPTSTPYLLFYKK 784
                 S     Y+LFY+K
Sbjct: 479 QFQGKES----AYMLFYRK 493



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 22/55 (40%), Positives = 31/55 (56%), Gaps = 7/55 (12%)

Query: 82  GLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKKEALKDEANQKDKGNCK 136
           G+ N G TCYLNS+LQ L+F P F+     LF++   +    +D    KDK + K
Sbjct: 54  GIRNQGGTCYLNSLLQTLHFTPEFREA---LFSLGPEELGLFED----KDKPDAK 101


>gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]
          Length = 396

 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 58/216 (26%), Positives = 95/216 (43%), Gaps = 37/216 (17%)

Query: 395 GLESPGNTVT------PVNVNEVKPINKGEEQIGFEL------VEKLFQGQLVLRTRCLE 442
           GL +  N VT      P N++ +    KG +     L      +  LF GQL     C +
Sbjct: 159 GLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTD 218

Query: 443 CESLTERREDFQDISVPVQEDELSKVEESSEISPEPKTEMKTLRWAISQFASVERIVGED 502
           C   +   + F D+S+P+ +    +V               TL   +  F   + + G++
Sbjct: 219 CGYCSTVFDPFWDLSLPIAKRGYPEV---------------TLMDCMRLFTKEDVLDGDE 263

Query: 503 KYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGLEFDCYGGGLSKINTPLLTPLK- 561
           K  C  C       +     + P+++ +HLK F+ S +         SK+ T +  PL+ 
Sbjct: 264 KPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIR-------TSKLTTFVNFPLRD 316

Query: 562 LSLEEWSTKPTNDS-YGLFAVVMHSGITISSGHYTA 596
           L L E++++ TN + Y L+AV  HSG T+  GHYTA
Sbjct: 317 LDLREFASENTNHAVYNLYAVSNHSGTTM-GGHYTA 351



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 40/153 (26%), Positives = 64/153 (41%), Gaps = 33/153 (21%)

Query: 82  GLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKKEALKDEANQK-DKGNCKEDSL 140
           GL NLGNTC++NSILQ L                 S  +E L+D   Q+    +    S 
Sbjct: 59  GLRNLGNTCFMNSILQCL-----------------SNTRE-LRDYCLQRLYMRDLHHGSN 100

Query: 141 ASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGYLQHDA 200
           A   L+     LI ++     + +++P ++  +           ++   P + GY Q DA
Sbjct: 101 AHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQ-----------IQRYAPRFVGYNQQDA 149

Query: 201 QEVLQCILGNIQETCQ---LLKKEEVKNVAELP 230
           QE L+ +L  +        L  K   +N+  LP
Sbjct: 150 QEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLP 182


>gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo
           sapiens]
          Length = 605

 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 58/216 (26%), Positives = 95/216 (43%), Gaps = 37/216 (17%)

Query: 395 GLESPGNTVT------PVNVNEVKPINKGEEQIGFEL------VEKLFQGQLVLRTRCLE 442
           GL +  N VT      P N++ +    KG +     L      +  LF GQL     C +
Sbjct: 368 GLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTD 427

Query: 443 CESLTERREDFQDISVPVQEDELSKVEESSEISPEPKTEMKTLRWAISQFASVERIVGED 502
           C   +   + F D+S+P+ +    +V               TL   +  F   + + G++
Sbjct: 428 CGYCSTVFDPFWDLSLPIAKRGYPEV---------------TLMDCMRLFTKEDVLDGDE 472

Query: 503 KYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGLEFDCYGGGLSKINTPLLTPLK- 561
           K  C  C       +     + P+++ +HLK F+ S +         SK+ T +  PL+ 
Sbjct: 473 KPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIR-------TSKLTTFVNFPLRD 525

Query: 562 LSLEEWSTKPTNDS-YGLFAVVMHSGITISSGHYTA 596
           L L E++++ TN + Y L+AV  HSG T+  GHYTA
Sbjct: 526 LDLREFASENTNHAVYNLYAVSNHSGTTM-GGHYTA 560



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 46/177 (25%), Positives = 74/177 (41%), Gaps = 40/177 (22%)

Query: 62  PAAQSSP----INCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIIS 117
           P+  SSP    +N +  + L    GL NLGNTC++NSILQ L                 S
Sbjct: 247 PSRSSSPGRDGMNSKSAQGL---AGLRNLGNTCFMNSILQCL-----------------S 286

Query: 118 RKKEALKDEANQK-DKGNCKEDSLASYELICSLQSLIISVEQLQASFLLNPEKYTDELAT 176
             +E L+D   Q+    +    S A   L+     LI ++     + +++P ++  +   
Sbjct: 287 NTRE-LRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQ--- 342

Query: 177 QPRRLLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQ---LLKKEEVKNVAELP 230
                   ++   P + GY Q DAQE L+ +L  +        L  K   +N+  LP
Sbjct: 343 --------IQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLP 391


>gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]
          Length = 438

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 52/197 (26%), Positives = 82/197 (41%), Gaps = 30/197 (15%)

Query: 425 LVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQED-----ELSKVEESSEISPEPK 479
           +++++F G L     C  C  ++   +   DIS+ +         +S   ESS       
Sbjct: 198 IIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGSCTSFWPMSPGRESSVNGESHI 257

Query: 480 TEMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASG 539
             + TL   + +F   E +    K  C +C  Y E+ + L  +K+P V   H K F  S 
Sbjct: 258 PGITTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRFEHSA 317

Query: 540 LEFDCYGGGLSKINTPLLTPLKLSLEEWSTK------------PTN-----DSYGLFAVV 582
            +         KI T +  PL+L +  +               PTN     + Y LFAVV
Sbjct: 318 KQ-------RRKITTYISFPLELDMTPFMASSKESRMNGQLQLPTNSGNNENKYSLFAVV 370

Query: 583 MHSGITISSGHYTASVK 599
            H G T+ SGHYT+ ++
Sbjct: 371 NHQG-TLESGHYTSFIR 386



 Score = 33.1 bits (74), Expect = 1.0
 Identities = 38/149 (25%), Positives = 56/149 (37%), Gaps = 35/149 (23%)

Query: 82  GLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKKEALKDEANQKDKGNCKEDSLA 141
           GL NLGNTC++N I+Q L   P                   +  +    D+  C+  S  
Sbjct: 79  GLINLGNTCFMNCIVQALTHTP-------------------ILRDFFLSDRHRCEMPS-P 118

Query: 142 SYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGYLQHDAQ 201
              L+C + SL       +  +  NP  +       P +LL+ +        GY Q DA 
Sbjct: 119 ELCLVCEMSSL------FRELYSGNPSPHV------PYKLLHLVWIHARHLAGYRQQDAH 166

Query: 202 EVLQCILGNIQETCQLLKKEEVKNVAELP 230
           E L   L  +   C   K ++V   A  P
Sbjct: 167 EFLIAALDVLHRHC---KGDDVGKAANNP 192


>gi|21361749 ubiquitin thioesterase 49 [Homo sapiens]
          Length = 640

 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 53/191 (27%), Positives = 85/191 (44%), Gaps = 29/191 (15%)

Query: 424 ELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKTEMK 483
           ++V  +F GQL+ +  C+ C   +   E F D+S+   E     +E+     P  +TE  
Sbjct: 439 KVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFPE-RYHCIEKG--FVPLNQTEC- 494

Query: 484 TLRWAISQFASVERIVGEDKYFCENCHH-----------YTEAERSLLFDKMPEVITIHL 532
            L   +++F   E + G   Y C+ C+             +EA + L+  ++P+V+ +HL
Sbjct: 495 LLTEMLAKFTETEALEGRI-YACDQCNSKRRKSNPKPLVLSEARKQLMIYRLPQVLRLHL 553

Query: 533 KCFAASGLEFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDS-------YGLFAVVMHS 585
           K F  SG           KI   ++    L++E +  +    S       Y L AVVMH 
Sbjct: 554 KRFRWSGRNHR------EKIGVHVVFDQVLTMEPYCCRDMLSSLDKETFAYDLSAVVMHH 607

Query: 586 GITISSGHYTA 596
           G    SGHYTA
Sbjct: 608 GKGFGSGHYTA 618



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 60/224 (26%), Positives = 94/224 (41%), Gaps = 42/224 (18%)

Query: 49  ASEYRASEIDQVVPAAQSSPINCEKRENLLPFV-GLNNLGNTCYLNSILQVLYFCPGFK- 106
           AS   A    + VPAA    +   ++  + P V GL NLGNTCY+NSILQVL     F+ 
Sbjct: 223 ASRPAALPTSRRVPAAT---LKLRRQPAMAPGVTGLRNLGNTCYMNSILQVLSHLQKFRE 279

Query: 107 -------SGVKHLFNIISRKKEALKDEAN---------QKDKGN-CKEDSLA-------- 141
                  S  +HLF   +  K  L  +           + D+   C+ +           
Sbjct: 280 CFLNLDPSKTEHLFPKATNGKTQLSGKPTNSSATELSLRNDRAEACEREGFCWNGRASIS 339

Query: 142 -SYELICSLQSLIISVEQLQASFLLNPEKYTDELA-TQPRRLLNTLRELNPMYEGYLQHD 199
            S ELI + +     +   +    L    ++ + A   P  +L+++  L P + GY Q D
Sbjct: 340 RSLELIQNKEPSSKHISLCRELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQD 399

Query: 200 AQEVLQCILGNIQETCQLLKKEEVKNVAELPTKVEEIPHPKEEM 243
           AQE L          C+LL K + +  +E  T+   IP  + ++
Sbjct: 400 AQEFL----------CELLHKVQQELESEGTTRRILIPFSQRKL 433


>gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]
          Length = 565

 Score = 60.1 bits (144), Expect = 8e-09
 Identities = 48/170 (28%), Positives = 78/170 (45%), Gaps = 23/170 (13%)

Query: 429 LFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKTEMKTLRWA 488
           LF GQL    +C  C   +   E F D+S+P+ +   +  + S             LR  
Sbjct: 373 LFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVS-------------LRDC 419

Query: 489 ISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGLEFDCYGGG 548
            + F   E +  E+   C+ C   T + + L   + P ++ +HL  F+AS        G 
Sbjct: 420 FNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSAS-------RGS 472

Query: 549 LSKINTPLLTPL-KLSLEEW-STKPTNDSYGLFAVVMHSGITISSGHYTA 596
           + K +  +  PL +LSL ++ S K  +  Y L+A+  HSG ++  GHYTA
Sbjct: 473 IKKSSVGVDFPLQRLSLGDFASDKAGSPVYQLYALCNHSG-SVHYGHYTA 521



 Score = 38.9 bits (89), Expect = 0.019
 Identities = 36/128 (28%), Positives = 56/128 (43%), Gaps = 29/128 (22%)

Query: 81  VGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKKEALKDEANQKDKGNCKEDSL 140
           VGL NLGNTC+LN++LQ L       S  + L      +   L+ +  Q+  G  +    
Sbjct: 212 VGLRNLGNTCFLNAVLQCL-------SSTRPL------RDFCLRRDFRQEVPGGGR---- 254

Query: 141 ASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGYLQHDA 200
            + EL  +   +I          L +P+      A  P R     ++  P + GY Q DA
Sbjct: 255 -AQELTEAFADVI--------GALWHPDSCE---AVNPTRFRAVFQKYVPSFSGYSQQDA 302

Query: 201 QEVLQCIL 208
           QE L+ ++
Sbjct: 303 QEFLKLLM 310


>gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]
          Length = 565

 Score = 60.1 bits (144), Expect = 8e-09
 Identities = 48/170 (28%), Positives = 78/170 (45%), Gaps = 23/170 (13%)

Query: 429 LFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKTEMKTLRWA 488
           LF GQL    +C  C   +   E F D+S+P+ +   +  + S             LR  
Sbjct: 373 LFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVS-------------LRDC 419

Query: 489 ISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGLEFDCYGGG 548
            + F   E +  E+   C+ C   T + + L   + P ++ +HL  F+AS        G 
Sbjct: 420 FNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSAS-------RGS 472

Query: 549 LSKINTPLLTPL-KLSLEEW-STKPTNDSYGLFAVVMHSGITISSGHYTA 596
           + K +  +  PL +LSL ++ S K  +  Y L+A+  HSG ++  GHYTA
Sbjct: 473 IKKSSVGVDFPLQRLSLGDFASDKAGSPVYQLYALCNHSG-SVHYGHYTA 521



 Score = 38.9 bits (89), Expect = 0.019
 Identities = 36/128 (28%), Positives = 56/128 (43%), Gaps = 29/128 (22%)

Query: 81  VGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKKEALKDEANQKDKGNCKEDSL 140
           VGL NLGNTC+LN++LQ L       S  + L      +   L+ +  Q+  G  +    
Sbjct: 212 VGLRNLGNTCFLNAVLQCL-------SSTRPL------RDFCLRRDFRQEVPGGGR---- 254

Query: 141 ASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGYLQHDA 200
            + EL  +   +I          L +P+      A  P R     ++  P + GY Q DA
Sbjct: 255 -AQELTEAFADVI--------GALWHPDSCE---AVNPTRFRAVFQKYVPSFSGYSQQDA 302

Query: 201 QEVLQCIL 208
           QE L+ ++
Sbjct: 303 QEFLKLLM 310


>gi|239742285 PREDICTED: hypothetical protein XP_002342486 [Homo
           sapiens]
          Length = 559

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 42/198 (21%), Positives = 87/198 (43%), Gaps = 28/198 (14%)

Query: 425 LVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKTEMKT 484
           L+ ++F G    + +CL C  +++  + + DI++ +Q  +                   +
Sbjct: 192 LIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQ-------------------S 232

Query: 485 LRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGLEFDC 544
           ++ A+ Q    E + GE+ Y C  C     A ++L      +V+ + LK F+      D 
Sbjct: 233 VQQALEQLVKPEELNGENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRFS------DV 286

Query: 545 YGGGLSK-INTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKVTDL 603
            G  + K +  P    +KL + + ++ P    Y L+AV++H+G +  +GHY + VK  + 
Sbjct: 287 TGNKIDKNVQYPECLDMKLYMSQTNSGPL--VYVLYAVLVHAGWSCHNGHYFSYVKAQEG 344

Query: 604 NSLELDKGNFVVDQMCEI 621
              ++D        +  +
Sbjct: 345 QWYKMDDAEVTASSITSV 362



 Score = 36.2 bits (82), Expect = 0.12
 Identities = 21/68 (30%), Positives = 29/68 (42%), Gaps = 4/68 (5%)

Query: 40  TDSQENEEKASEYRASEIDQVVPAAQS----SPINCEKRENLLPFVGLNNLGNTCYLNSI 95
           T   E    + E R    D + P A+       +    R       GL N+GNTCY+N+ 
Sbjct: 35  TSLPEKSPLSCETRVDLCDDLAPVARQLAPREKLPLSSRRPAAVGAGLQNMGNTCYVNAS 94

Query: 96  LQVLYFCP 103
           LQ L + P
Sbjct: 95  LQCLTYTP 102


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.129    0.361 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,947,510
Number of Sequences: 37866
Number of extensions: 1464690
Number of successful extensions: 5727
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 114
Number of HSP's successfully gapped in prelim test: 183
Number of HSP's that attempted gapping in prelim test: 4983
Number of HSP's gapped (non-prelim): 797
length of query: 785
length of database: 18,247,518
effective HSP length: 110
effective length of query: 675
effective length of database: 14,082,258
effective search space: 9505524150
effective search space used: 9505524150
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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