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Search of human proteins with 13443014
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13443014 ankyrin repeat and SOCS box-containing 9 isoform 2
[Homo sapiens]
(262 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13443014 ankyrin repeat and SOCS box-containing 9 isoform 2 [... 543 e-155
gi|72534772 ankyrin repeat and SOCS box-containing 9 isoform 1 [... 526 e-150
gi|60218887 ankyrin repeat and SOCS box-containing protein 11 is... 248 5e-66
gi|18254474 ankyrin repeat and SOCS box-containing protein 11 is... 245 2e-65
gi|18254476 ankyrin repeat and SOCS box-containing protein 5 [Ho... 241 6e-64
gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [H... 176 2e-44
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 103 2e-22
gi|157743292 ankyrin repeat and SOCS box-containing 18 [Homo sap... 102 3e-22
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 101 6e-22
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 101 6e-22
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 101 6e-22
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 101 6e-22
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 101 6e-22
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 101 8e-22
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 101 8e-22
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 97 1e-20
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 97 1e-20
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 97 1e-20
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 97 1e-20
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 97 2e-20
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 97 2e-20
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 97 2e-20
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof... 96 4e-20
gi|24586688 ankyrin repeat and SOCS box-containing protein 16 [H... 94 9e-20
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho... 94 2e-19
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 93 2e-19
gi|16975496 cortactin binding protein 2 [Homo sapiens] 93 3e-19
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 92 4e-19
gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2... 92 4e-19
gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1... 92 4e-19
>gi|13443014 ankyrin repeat and SOCS box-containing 9 isoform 2
[Homo sapiens]
Length = 262
Score = 543 bits (1398), Expect = e-155
Identities = 262/262 (100%), Positives = 262/262 (100%)
Query: 1 MDGKQGGMDGSKPAGPRDFPGIRLLSNPLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGW 60
MDGKQGGMDGSKPAGPRDFPGIRLLSNPLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGW
Sbjct: 1 MDGKQGGMDGSKPAGPRDFPGIRLLSNPLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGW 60
Query: 61 AVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNL 120
AVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNL
Sbjct: 61 AVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNL 120
Query: 121 LLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQR 180
LLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQR
Sbjct: 121 LLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQR 180
Query: 181 ACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVP 240
ACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVP
Sbjct: 181 ACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVP 240
Query: 241 PESPLAQLFLEREGASLPKPKP 262
PESPLAQLFLEREGASLPKPKP
Sbjct: 241 PESPLAQLFLEREGASLPKPKP 262
>gi|72534772 ankyrin repeat and SOCS box-containing 9 isoform 1
[Homo sapiens]
Length = 294
Score = 526 bits (1355), Expect = e-150
Identities = 254/254 (100%), Positives = 254/254 (100%)
Query: 1 MDGKQGGMDGSKPAGPRDFPGIRLLSNPLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGW 60
MDGKQGGMDGSKPAGPRDFPGIRLLSNPLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGW
Sbjct: 1 MDGKQGGMDGSKPAGPRDFPGIRLLSNPLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGW 60
Query: 61 AVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNL 120
AVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNL
Sbjct: 61 AVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNL 120
Query: 121 LLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQR 180
LLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQR
Sbjct: 121 LLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQR 180
Query: 181 ACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVP 240
ACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVP
Sbjct: 181 ACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVP 240
Query: 241 PESPLAQLFLEREG 254
PESPLAQLFLEREG
Sbjct: 241 PESPLAQLFLEREG 254
>gi|60218887 ankyrin repeat and SOCS box-containing protein 11
isoform b [Homo sapiens]
Length = 302
Score = 248 bits (632), Expect = 5e-66
Identities = 124/230 (53%), Positives = 162/230 (70%)
Query: 25 LSNPLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSC 84
+ + GD +D SP+HEAA G L+L+ LI+QG VN++T + VS LHEACLGGH++C
Sbjct: 33 ICHTFQGDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVAC 92
Query: 85 VKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARR 144
K LL++GA VNGVT TPLFNAC SGS CVN+LL+ GA Q E LASPIHEA +R
Sbjct: 93 AKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKR 152
Query: 145 GHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLH 204
GH EC+ L+A NIDH++ LGTPLY+AC Q+ CVKKLLE GA V+ G+ D+PLH
Sbjct: 153 GHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLH 212
Query: 205 AVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPESPLAQLFLEREG 254
A AR ++ E+ LL D+GA+ + +NA+GK ++L P+S + Q L REG
Sbjct: 213 AAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREG 262
>gi|18254474 ankyrin repeat and SOCS box-containing protein 11
isoform a [Homo sapiens]
Length = 323
Score = 245 bits (626), Expect = 2e-65
Identities = 123/225 (54%), Positives = 160/225 (71%)
Query: 30 MGDAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILL 89
+ D +D SP+HEAA G L+L+ LI+QG VN++T + VS LHEACLGGH++C K LL
Sbjct: 59 ISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALL 118
Query: 90 KHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVEC 149
++GA VNGVT TPLFNAC SGS CVN+LL+ GA Q E LASPIHEA +RGH EC
Sbjct: 119 ENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHREC 178
Query: 150 VNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVART 209
+ L+A NIDH++ LGTPLY+AC Q+ CVKKLLE GA V+ G+ D+PLHA AR
Sbjct: 179 MEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQ 238
Query: 210 ASEELACLLMDFGADTQAKNAEGKRPVELVPPESPLAQLFLEREG 254
++ E+ LL D+GA+ + +NA+GK ++L P+S + Q L REG
Sbjct: 239 SNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREG 283
>gi|18254476 ankyrin repeat and SOCS box-containing protein 5 [Homo
sapiens]
Length = 329
Score = 241 bits (614), Expect = 6e-64
Identities = 117/219 (53%), Positives = 157/219 (71%)
Query: 35 SDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQ 94
+D SP+HEAA G L+LR L+SQG+ VN +T DHV+PLHEACLG H++C + LL+ GA
Sbjct: 69 ADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGAN 128
Query: 95 VNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLI 154
VN +T D TPLFNAC GS C LLL++GA Q ES L SP HEAA +GH EC++ LI
Sbjct: 129 VNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAASKGHHECLDILI 188
Query: 155 AYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEEL 214
++G ++D +I HLGTPLY+AC +QQ C+ KLL +GADV +GK D+PLHA A+ +S E+
Sbjct: 189 SWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAAAQQSSTEI 248
Query: 215 ACLLMDFGADTQAKNAEGKRPVELVPPESPLAQLFLERE 253
LL++FGAD AKN E RP+++ S + ++ L+ E
Sbjct: 249 VNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQHE 287
>gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [Homo
sapiens]
Length = 278
Score = 176 bits (446), Expect = 2e-44
Identities = 92/212 (43%), Positives = 126/212 (59%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+HEAA G L L+ LI G VN +T D ++PLH A L G CV++LL GAQV+
Sbjct: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
Query: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYG 157
D TPL +AC SGS +CV LLL +GA V P ASP+HEA G ECV LI G
Sbjct: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVG 140
Query: 158 GNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACL 217
N++ H GTPL++AC + CVK LL +GA+VN K ++ LH A+ + +L +
Sbjct: 141 ANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEM 200
Query: 218 LMDFGADTQAKNAEGKRPVELVPPESPLAQLF 249
L++FG + A++ GK+P + S A+ F
Sbjct: 201 LIEFGGNIYARDNRGKKPSDYTWSSSAPAKCF 232
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 103 bits (257), Expect = 2e-22
Identities = 76/234 (32%), Positives = 111/234 (47%), Gaps = 5/234 (2%)
Query: 28 PLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKI 87
P++ + SP+H A H ++ L+ V+ +T D+++ LH A GH K+
Sbjct: 326 PILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKV 385
Query: 88 LLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQ--PESDLASPIHEAARRG 145
LL A N + TPL AC + LLL+HGAS+Q ES L +PIH AA G
Sbjct: 386 LLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGL-TPIHVAAFMG 444
Query: 146 HVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLH 204
HV V+ L+ +G + + T L++A + Q V+ L++ GA V + K +PLH
Sbjct: 445 HVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLH 504
Query: 205 AVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPES-PLAQLFLEREGASL 257
AR ++ L+ GA A G P+ L E FL GASL
Sbjct: 505 ISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASL 558
Score = 90.9 bits (224), Expect = 1e-18
Identities = 63/213 (29%), Positives = 99/213 (46%), Gaps = 2/213 (0%)
Query: 35 SDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQ 94
S +P+H AA GH + L+ G + N + LH A G V+ L++ GAQ
Sbjct: 432 SGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQ 491
Query: 95 VNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECVNSL 153
V D TPL + G D V LLQ GAS + +P+H +AR GH + L
Sbjct: 492 VEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFL 551
Query: 154 IAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ-GKGQDSPLHAVARTASE 212
+ +G ++ TPL++A + + LL+ A + GK +PLH A ++
Sbjct: 552 LDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQ 611
Query: 213 ELACLLMDFGADTQAKNAEGKRPVELVPPESPL 245
++A LL+D GA A G P+ + ++ +
Sbjct: 612 KVALLLLDQGASPHAAAKNGYTPLHIAAKKNQM 644
Score = 85.9 bits (211), Expect = 3e-17
Identities = 59/209 (28%), Positives = 103/209 (49%), Gaps = 2/209 (0%)
Query: 32 DAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKH 91
++ S ++P+H AA +G+ L+++ AV+ + ++PLH A G+ + VK+LL
Sbjct: 231 ESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDR 290
Query: 92 GAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPES-DLASPIHEAARRGHVECV 150
GA+++ T D TPL SG V +LL A + ++ + SP+H A + H+ CV
Sbjct: 291 GAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCV 350
Query: 151 NSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAVART 209
L+ + +D + T L++A K LL+ A+ N + +PLH +
Sbjct: 351 QLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKK 410
Query: 210 ASEELACLLMDFGADTQAKNAEGKRPVEL 238
++ LL+ GA QA G P+ +
Sbjct: 411 NRIKVMELLLKHGASIQAVTESGLTPIHV 439
Score = 85.9 bits (211), Expect = 3e-17
Identities = 63/212 (29%), Positives = 93/212 (43%), Gaps = 2/212 (0%)
Query: 33 AVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHG 92
A D +P+H +A G ++ L+ QG + N T +PLH + GH LL HG
Sbjct: 496 AKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHG 555
Query: 93 AQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECVN 151
A ++ T TPL A G + NLLLQ AS +P+H AA + +
Sbjct: 556 ASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVAL 615
Query: 152 SLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQD-SPLHAVARTA 210
L+ G + + TPL++A + Q LLE GAD N Q + +H A+
Sbjct: 616 LLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEG 675
Query: 211 SEELACLLMDFGADTQAKNAEGKRPVELVPPE 242
++ LL+ A+ N G P+ L E
Sbjct: 676 HVDMVSLLLGRNANVNLSNKSGLTPLHLAAQE 707
Score = 73.6 bits (179), Expect = 2e-13
Identities = 58/190 (30%), Positives = 92/190 (48%), Gaps = 6/190 (3%)
Query: 43 AAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADW 102
AA GH + I G +NI + ++ LH A GH+ V LL+ A V+ T
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 103 HTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECVNSLIAYGGNID 161
+T L A ++G + V +L+ +GA+V +S +P++ AA+ H+E V L+ G +
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQS 167
Query: 162 HKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLM-- 219
TPL +A + V LLE+ +GK + LH AR + A LL+
Sbjct: 168 LATEDGFTPLAVALQQGHDQVVSLLLEND---TKGKVRLPALHIAARKDDTKAAALLLQN 224
Query: 220 DFGADTQAKN 229
D AD ++K+
Sbjct: 225 DNNADVESKS 234
Score = 67.8 bits (164), Expect = 9e-12
Identities = 42/164 (25%), Positives = 75/164 (45%), Gaps = 1/164 (0%)
Query: 33 AVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHG 92
A + ++P+H AA L+ G N +T ++ +H A GH+ V +LL
Sbjct: 628 AKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRN 687
Query: 93 AQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECVN 151
A VN TPL A + +L+ GA V ++ + +P+H G+++ VN
Sbjct: 688 ANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVN 747
Query: 152 SLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ 195
L+ + ++ K + TPL+ A + + LL++ A N+
Sbjct: 748 FLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNE 791
Score = 67.4 bits (163), Expect = 1e-11
Identities = 63/255 (24%), Positives = 101/255 (39%), Gaps = 33/255 (12%)
Query: 40 MHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVT 99
+H A+ GH + L+ + V+ T + LH A L G VK+L+ +GA VN +
Sbjct: 78 LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS 137
Query: 100 ADWHTPLFNACVSGSWDCVNLLLQHGA-------------------------SVQPESDL 134
+ TPL+ A + V LL +GA S+ E+D
Sbjct: 138 QNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDT 197
Query: 135 ASPI-----HEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLES 189
+ H AAR+ + L+ N D + TPL++A LL
Sbjct: 198 KGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNR 257
Query: 190 GADVN-QGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVE--LVPPESPLA 246
A V+ + +PLH ++ + + LL+D GA AK +G P+ +
Sbjct: 258 AAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVV 317
Query: 247 QLFLEREGASLPKPK 261
++ L+R L K K
Sbjct: 318 EMLLDRAAPILSKTK 332
Score = 67.0 bits (162), Expect = 2e-11
Identities = 57/206 (27%), Positives = 95/206 (46%), Gaps = 10/206 (4%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVN 96
++P++ AA H ++ L+ G + ++ T D +PL A GH V +LL+ N
Sbjct: 141 FTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLE-----N 195
Query: 97 GVTADWHTP-LFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECVNSLI 154
P L A LLLQ+ + ES +P+H AA G++ L+
Sbjct: 196 DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLL 255
Query: 155 AYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQD--SPLHAVARTASE 212
+D + TPL++A + VK LL+ GA ++ K +D +PLH AR+ E
Sbjct: 256 NRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKID-AKTRDGLTPLHCGARSGHE 314
Query: 213 ELACLLMDFGADTQAKNAEGKRPVEL 238
++ +L+D A +K G P+ +
Sbjct: 315 QVVEMLLDRAAPILSKTKNGLSPLHM 340
Score = 60.1 bits (144), Expect = 2e-09
Identities = 40/120 (33%), Positives = 61/120 (50%), Gaps = 1/120 (0%)
Query: 35 SDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQ 94
S +P+H AA L++QG V+ T +PLH C G++ V LL+H A+
Sbjct: 696 SGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAK 755
Query: 95 VNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARR-GHVECVNSL 153
VN T + +TPL A G +N+LLQ+ AS + + ARR G++ V++L
Sbjct: 756 VNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815
Score = 39.7 bits (91), Expect = 0.003
Identities = 36/128 (28%), Positives = 61/128 (47%), Gaps = 2/128 (1%)
Query: 131 ESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESG 190
+SD + AAR GH+E I G +I+ + L+LA + V +LL+
Sbjct: 38 KSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQRE 97
Query: 191 ADVNQG-KGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPESPLAQL- 248
A+V+ K ++ LH + E+ +L+ GA+ A++ G P+ + E+ L +
Sbjct: 98 ANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVK 157
Query: 249 FLEREGAS 256
FL GAS
Sbjct: 158 FLLDNGAS 165
>gi|157743292 ankyrin repeat and SOCS box-containing 18 [Homo
sapiens]
Length = 466
Score = 102 bits (255), Expect = 3e-22
Identities = 72/210 (34%), Positives = 107/210 (50%), Gaps = 12/210 (5%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+ AA HGH +R+L+ +G + LHEACLGGH +CV++LL+H A +
Sbjct: 122 TPLCIAAAHGHTACVRHLLGRGADPDASPGGR-GALHEACLGGHTACVRLLLQHRADPDL 180
Query: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA--SPIHEAARRGHVECVNSLIA 155
++A+ PL + S C LL+HGASVQ +P+H AA+RG E +
Sbjct: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
Query: 156 YGGNIDHKISHLGTPLYLACENQQR-----ACVK---KLLESGADVN-QGKGQDSPLHAV 206
G ++D + T L AC +R C++ LL GA+ + + + + SPLH
Sbjct: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
Query: 207 ARTASEELACLLMDFGADTQAKNAEGKRPV 236
AS LA LL+ GAD A + G P+
Sbjct: 301 CGHASHSLARLLLRHGADAGALDYGGASPL 330
Score = 49.3 bits (116), Expect = 3e-06
Identities = 37/141 (26%), Positives = 56/141 (39%), Gaps = 34/141 (24%)
Query: 127 SVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLG------------------ 168
+++ + +L +P+ AA GH CV L+ G + D G
Sbjct: 113 TLEYKRELTTPLCIAAAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRLLL 172
Query: 169 --------------TPLYLACENQQRACVKKLLESGADVNQ--GKGQDSPLHAVARTASE 212
PL+L C + LLE GA V + G G+D+PLH A+ +
Sbjct: 173 QHRADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLD 232
Query: 213 ELACLLMDFGADTQAKNAEGK 233
E A L + GA A+N G+
Sbjct: 233 EHARLYLGRGAHVDARNGRGE 253
Score = 43.5 bits (101), Expect = 2e-04
Identities = 33/95 (34%), Positives = 43/95 (45%), Gaps = 3/95 (3%)
Query: 167 LGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQ 226
L TPL +A + ACV+ LL GAD + G LH LL+ AD
Sbjct: 120 LTTPLCIAAAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRLLLQHRADPD 179
Query: 227 AKNAEGKRPVELVPPESPL--AQLFLEREGASLPK 259
+AEG P+ L + L AQ LE GAS+ +
Sbjct: 180 LLSAEGLAPLHLCRTAASLGCAQALLE-HGASVQR 213
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 101 bits (252), Expect = 6e-22
Identities = 72/233 (30%), Positives = 112/233 (48%), Gaps = 6/233 (2%)
Query: 28 PLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKI 87
P+ + SP+H AA H +R L+ ++ IT DH++PLH A GH K+
Sbjct: 330 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 389
Query: 88 LLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQ--PESDLASPIHEAARRG 145
LL GA+ N + TPL AC + LLL+ GAS+ ES L +P+H A+ G
Sbjct: 390 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMG 448
Query: 146 HVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLH 204
H+ V +L+ G + + + TPL++A K LL++ A VN + K +PLH
Sbjct: 449 HLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH 508
Query: 205 AVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPESPLAQL--FLEREGA 255
AR + LL++ A+ G P+ + E + + LE+E +
Sbjct: 509 CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 561
Score = 99.0 bits (245), Expect = 4e-21
Identities = 78/240 (32%), Positives = 121/240 (50%), Gaps = 9/240 (3%)
Query: 24 LLSNPLMGDAVSD--WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGH 81
LL N D +S ++P+H AA + + + L+++G +VN + ++PLH A G+
Sbjct: 225 LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN 284
Query: 82 LSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPES-DLASPIHE 140
+ V++LL GAQ+ T D TPL A +G +LL HGA +Q ++ + SPIH
Sbjct: 285 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 344
Query: 141 AARRGHVECVNSLIAYGGNIDH-KISHLGTPLYLACENQQRACVKKLLESGADVN-QGKG 198
AA+ H++CV L+ Y ID + HL TPL++A K LL+ GA N +
Sbjct: 345 AAQGDHLDCVRLLLQYDAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 403
Query: 199 QDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVP--PESPLAQLFLEREGAS 256
+PLH + + LL+ GA A G P+ + P+ + L+R GAS
Sbjct: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQR-GAS 462
Score = 94.7 bits (234), Expect = 7e-20
Identities = 58/203 (28%), Positives = 102/203 (50%), Gaps = 2/203 (0%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+H A+ G+ + +R L+ +G + T D ++PLH A GH+ +ILL HGA +
Sbjct: 274 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 333
Query: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQPES-DLASPIHEAARRGHVECVNSLIAY 156
T + +P+ A DCV LLLQ+ A + + D +P+H AA GH L+
Sbjct: 334 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 393
Query: 157 GGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ-GKGQDSPLHAVARTASEELA 215
G + + + TPL++AC+ ++ LL++GA ++ + +PLH + +
Sbjct: 394 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 453
Query: 216 CLLMDFGADTQAKNAEGKRPVEL 238
L+ GA N + + P+ +
Sbjct: 454 KNLLQRGASPNVSNVKVETPLHM 476
Score = 84.3 bits (207), Expect = 1e-16
Identities = 63/203 (31%), Positives = 97/203 (47%), Gaps = 2/203 (0%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+H AA GH ++ L+ + + +T +PLH A G + ++LL+ A N
Sbjct: 538 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 597
Query: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQ-PESDLASPIHEAARRGHVECVNSLIAY 156
+ TPL A + D V LLL G S P + +P+H AA++ VE SL+ Y
Sbjct: 598 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 657
Query: 157 GGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQG-KGQDSPLHAVARTASEELA 215
GG+ + + TPL+LA + V LL A+ N G K +PLH VA+ +A
Sbjct: 658 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 717
Query: 216 CLLMDFGADTQAKNAEGKRPVEL 238
+L+ G A G P+ +
Sbjct: 718 DVLIKHGVMVDATTRMGYTPLHV 740
Score = 83.2 bits (204), Expect = 2e-16
Identities = 66/230 (28%), Positives = 103/230 (44%), Gaps = 31/230 (13%)
Query: 40 MHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVT 99
+H AA+ G +R L++ G VN + +PL+ A HL VK LL++GA N T
Sbjct: 115 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 174
Query: 100 ADWHTPLFNACVSGSWDCVNLLLQHG---------------------ASV----QPESDL 134
D TPL A G + V L+ +G A+V P D+
Sbjct: 175 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 234
Query: 135 AS-----PIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLES 189
S P+H AA ++ L+ G +++ + TPL++A V+ LL+
Sbjct: 235 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 294
Query: 190 GADV-NQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVEL 238
GA + + K + +PLH AR ++ +L+D GA QAK G P+ +
Sbjct: 295 GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 344
Score = 81.6 bits (200), Expect = 6e-16
Identities = 64/223 (28%), Positives = 99/223 (44%), Gaps = 4/223 (1%)
Query: 33 AVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHG 92
A D +P+H AA GH ++ L+ N+ T +PLH A GH+ V LL+
Sbjct: 500 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 559
Query: 93 AQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPE-SDLASPIHEAARRGHVECVN 151
A +T TPL A G LLL+ A + +P+H A +++ V
Sbjct: 560 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 619
Query: 152 SLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQD-SPLHAVARTA 210
L+ GG+ + TPL++A + Q + LL+ G N Q +PLH A+
Sbjct: 620 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG 679
Query: 211 SEELACLLMDFGADTQAKNAEGKRPVELVPPES--PLAQLFLE 251
E+ LL+ A+ N G P+ LV E P+A + ++
Sbjct: 680 HAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 722
Score = 80.5 bits (197), Expect = 1e-15
Identities = 49/144 (34%), Positives = 76/144 (52%), Gaps = 1/144 (0%)
Query: 32 DAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKH 91
++V +P+H AA GH + L+S+ N+ ++PLH GH+ +L+KH
Sbjct: 664 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 723
Query: 92 GAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECV 150
G V+ T +TPL A G+ V LLQH A V ++ L SP+H+AA++GH + V
Sbjct: 724 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 783
Query: 151 NSLIAYGGNIDHKISHLGTPLYLA 174
L+ G + + S TPL +A
Sbjct: 784 TLLLKNGASPNEVSSDGTTPLAIA 807
Score = 73.6 bits (179), Expect = 2e-13
Identities = 67/237 (28%), Positives = 104/237 (43%), Gaps = 35/237 (14%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVN 96
++P+H AA +G L+ + N + ++PLH A +L VK+LL G +
Sbjct: 570 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 629
Query: 97 GVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPES-DLASPIHEAARRGHVECVNSLIA 155
+ +TPL A + LLQ+G S ES +P+H AA+ GH E V L++
Sbjct: 630 SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 689
Query: 156 --YGGNIDHK---------------------ISH---------LG-TPLYLACENQQRAC 182
GN+ +K I H +G TPL++A
Sbjct: 690 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 749
Query: 183 VKKLLESGADVN-QGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVEL 238
VK LL+ ADVN + K SPLH A+ ++ LL+ GA +++G P+ +
Sbjct: 750 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAI 806
Score = 68.9 bits (167), Expect = 4e-12
Identities = 47/177 (26%), Positives = 83/177 (46%), Gaps = 1/177 (0%)
Query: 33 AVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHG 92
A + ++P+H AA R+L+ G + N + V+PLH A GH V +LL
Sbjct: 632 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 691
Query: 93 AQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECVN 151
A N TPL G ++L++HG V + + +P+H A+ G+++ V
Sbjct: 692 ANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVK 751
Query: 152 SLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVAR 208
L+ + +++ K +PL+ A + V LL++GA N+ + A+A+
Sbjct: 752 FLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 808
Score = 66.6 bits (161), Expect = 2e-11
Identities = 59/228 (25%), Positives = 94/228 (41%), Gaps = 31/228 (13%)
Query: 40 MHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVT 99
+H A+ GH + L+ + + T + LH A L G V+ L+ +GA VN +
Sbjct: 82 LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 141
Query: 100 ADWHTPLFNACVSGSWDCVNLLLQHGASVQ-PESDLASPIHEAARRGHVECVNSLIAYG- 157
TPL+ A + V LL++GA+ D +P+ A ++GH V LI YG
Sbjct: 142 QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT 201
Query: 158 -GNIDHKISHLG---------------------------TPLYLACENQQRACVKKLLES 189
G + H+ TPL++A + + LL
Sbjct: 202 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 261
Query: 190 GADVN-QGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPV 236
GA VN + +PLH +R + + LL+D GA + K + P+
Sbjct: 262 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 309
Score = 65.1 bits (157), Expect = 6e-11
Identities = 44/120 (36%), Positives = 61/120 (50%), Gaps = 1/120 (0%)
Query: 35 SDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQ 94
S +P+H A GH LI G V+ T +PLH A G++ VK LL+H A
Sbjct: 700 SGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD 759
Query: 95 VNGVTADWHTPLFNACVSGSWDCVNLLLQHGASV-QPESDLASPIHEAARRGHVECVNSL 153
VN T ++PL A G D V LLL++GAS + SD +P+ A R G++ + L
Sbjct: 760 VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
Score = 33.5 bits (75), Expect = 0.19
Identities = 33/129 (25%), Positives = 63/129 (48%), Gaps = 4/129 (3%)
Query: 131 ESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLL--E 188
++D A+ AAR G+++ + G +I+ + L+LA + V +LL E
Sbjct: 42 KADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 101
Query: 189 SGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPESPLAQL 248
+ KG ++ LH A +E+ L+++GA+ A++ +G P+ + E+ L +
Sbjct: 102 IILETTTKKG-NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 160
Query: 249 -FLEREGAS 256
FL GA+
Sbjct: 161 KFLLENGAN 169
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 101 bits (252), Expect = 6e-22
Identities = 72/233 (30%), Positives = 112/233 (48%), Gaps = 6/233 (2%)
Query: 28 PLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKI 87
P+ + SP+H AA H +R L+ ++ IT DH++PLH A GH K+
Sbjct: 297 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 356
Query: 88 LLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQ--PESDLASPIHEAARRG 145
LL GA+ N + TPL AC + LLL+ GAS+ ES L +P+H A+ G
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMG 415
Query: 146 HVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLH 204
H+ V +L+ G + + + TPL++A K LL++ A VN + K +PLH
Sbjct: 416 HLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH 475
Query: 205 AVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPESPLAQL--FLEREGA 255
AR + LL++ A+ G P+ + E + + LE+E +
Sbjct: 476 CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Score = 99.0 bits (245), Expect = 4e-21
Identities = 78/240 (32%), Positives = 121/240 (50%), Gaps = 9/240 (3%)
Query: 24 LLSNPLMGDAVSD--WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGH 81
LL N D +S ++P+H AA + + + L+++G +VN + ++PLH A G+
Sbjct: 192 LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN 251
Query: 82 LSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPES-DLASPIHE 140
+ V++LL GAQ+ T D TPL A +G +LL HGA +Q ++ + SPIH
Sbjct: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 311
Query: 141 AARRGHVECVNSLIAYGGNIDH-KISHLGTPLYLACENQQRACVKKLLESGADVN-QGKG 198
AA+ H++CV L+ Y ID + HL TPL++A K LL+ GA N +
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370
Query: 199 QDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVP--PESPLAQLFLEREGAS 256
+PLH + + LL+ GA A G P+ + P+ + L+R GAS
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQR-GAS 429
Score = 94.7 bits (234), Expect = 7e-20
Identities = 58/203 (28%), Positives = 102/203 (50%), Gaps = 2/203 (0%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+H A+ G+ + +R L+ +G + T D ++PLH A GH+ +ILL HGA +
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQPES-DLASPIHEAARRGHVECVNSLIAY 156
T + +P+ A DCV LLLQ+ A + + D +P+H AA GH L+
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 157 GGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ-GKGQDSPLHAVARTASEELA 215
G + + + TPL++AC+ ++ LL++GA ++ + +PLH + +
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 216 CLLMDFGADTQAKNAEGKRPVEL 238
L+ GA N + + P+ +
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHM 443
Score = 84.3 bits (207), Expect = 1e-16
Identities = 63/203 (31%), Positives = 97/203 (47%), Gaps = 2/203 (0%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+H AA GH ++ L+ + + +T +PLH A G + ++LL+ A N
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564
Query: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQ-PESDLASPIHEAARRGHVECVNSLIAY 156
+ TPL A + D V LLL G S P + +P+H AA++ VE SL+ Y
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 157 GGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQG-KGQDSPLHAVARTASEELA 215
GG+ + + TPL+LA + V LL A+ N G K +PLH VA+ +A
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 216 CLLMDFGADTQAKNAEGKRPVEL 238
+L+ G A G P+ +
Sbjct: 685 DVLIKHGVMVDATTRMGYTPLHV 707
Score = 83.2 bits (204), Expect = 2e-16
Identities = 66/230 (28%), Positives = 103/230 (44%), Gaps = 31/230 (13%)
Query: 40 MHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVT 99
+H AA+ G +R L++ G VN + +PL+ A HL VK LL++GA N T
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 100 ADWHTPLFNACVSGSWDCVNLLLQHG---------------------ASV----QPESDL 134
D TPL A G + V L+ +G A+V P D+
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201
Query: 135 AS-----PIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLES 189
S P+H AA ++ L+ G +++ + TPL++A V+ LL+
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261
Query: 190 GADV-NQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVEL 238
GA + + K + +PLH AR ++ +L+D GA QAK G P+ +
Sbjct: 262 GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 311
Score = 81.6 bits (200), Expect = 6e-16
Identities = 64/223 (28%), Positives = 99/223 (44%), Gaps = 4/223 (1%)
Query: 33 AVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHG 92
A D +P+H AA GH ++ L+ N+ T +PLH A GH+ V LL+
Sbjct: 467 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526
Query: 93 AQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPE-SDLASPIHEAARRGHVECVN 151
A +T TPL A G LLL+ A + +P+H A +++ V
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586
Query: 152 SLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQD-SPLHAVARTA 210
L+ GG+ + TPL++A + Q + LL+ G N Q +PLH A+
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG 646
Query: 211 SEELACLLMDFGADTQAKNAEGKRPVELVPPES--PLAQLFLE 251
E+ LL+ A+ N G P+ LV E P+A + ++
Sbjct: 647 HAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Score = 80.5 bits (197), Expect = 1e-15
Identities = 49/144 (34%), Positives = 76/144 (52%), Gaps = 1/144 (0%)
Query: 32 DAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKH 91
++V +P+H AA GH + L+S+ N+ ++PLH GH+ +L+KH
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 92 GAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECV 150
G V+ T +TPL A G+ V LLQH A V ++ L SP+H+AA++GH + V
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
Query: 151 NSLIAYGGNIDHKISHLGTPLYLA 174
L+ G + + S TPL +A
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIA 774
Score = 73.6 bits (179), Expect = 2e-13
Identities = 67/237 (28%), Positives = 104/237 (43%), Gaps = 35/237 (14%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVN 96
++P+H AA +G L+ + N + ++PLH A +L VK+LL G +
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 97 GVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPES-DLASPIHEAARRGHVECVNSLIA 155
+ +TPL A + LLQ+G S ES +P+H AA+ GH E V L++
Sbjct: 597 SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656
Query: 156 --YGGNIDHK---------------------ISH---------LG-TPLYLACENQQRAC 182
GN+ +K I H +G TPL++A
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716
Query: 183 VKKLLESGADVN-QGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVEL 238
VK LL+ ADVN + K SPLH A+ ++ LL+ GA +++G P+ +
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAI 773
Score = 68.9 bits (167), Expect = 4e-12
Identities = 47/177 (26%), Positives = 83/177 (46%), Gaps = 1/177 (0%)
Query: 33 AVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHG 92
A + ++P+H AA R+L+ G + N + V+PLH A GH V +LL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 93 AQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECVN 151
A N TPL G ++L++HG V + + +P+H A+ G+++ V
Sbjct: 659 ANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVK 718
Query: 152 SLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVAR 208
L+ + +++ K +PL+ A + V LL++GA N+ + A+A+
Sbjct: 719 FLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
Score = 66.6 bits (161), Expect = 2e-11
Identities = 59/228 (25%), Positives = 94/228 (41%), Gaps = 31/228 (13%)
Query: 40 MHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVT 99
+H A+ GH + L+ + + T + LH A L G V+ L+ +GA VN +
Sbjct: 49 LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108
Query: 100 ADWHTPLFNACVSGSWDCVNLLLQHGASVQ-PESDLASPIHEAARRGHVECVNSLIAYG- 157
TPL+ A + V LL++GA+ D +P+ A ++GH V LI YG
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT 168
Query: 158 -GNIDHKISHLG---------------------------TPLYLACENQQRACVKKLLES 189
G + H+ TPL++A + + LL
Sbjct: 169 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228
Query: 190 GADVN-QGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPV 236
GA VN + +PLH +R + + LL+D GA + K + P+
Sbjct: 229 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276
Score = 65.1 bits (157), Expect = 6e-11
Identities = 44/120 (36%), Positives = 61/120 (50%), Gaps = 1/120 (0%)
Query: 35 SDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQ 94
S +P+H A GH LI G V+ T +PLH A G++ VK LL+H A
Sbjct: 667 SGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD 726
Query: 95 VNGVTADWHTPLFNACVSGSWDCVNLLLQHGASV-QPESDLASPIHEAARRGHVECVNSL 153
VN T ++PL A G D V LLL++GAS + SD +P+ A R G++ + L
Sbjct: 727 VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 35.0 bits (79), Expect = 0.066
Identities = 34/129 (26%), Positives = 63/129 (48%), Gaps = 4/129 (3%)
Query: 131 ESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLL--E 188
E+D A+ AAR G+++ + G +I+ + L+LA + V +LL E
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
Query: 189 SGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPESPLAQL 248
+ KG ++ LH A +E+ L+++GA+ A++ +G P+ + E+ L +
Sbjct: 69 IILETTTKKG-NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
Query: 249 -FLEREGAS 256
FL GA+
Sbjct: 128 KFLLENGAN 136
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 101 bits (252), Expect = 6e-22
Identities = 72/233 (30%), Positives = 112/233 (48%), Gaps = 6/233 (2%)
Query: 28 PLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKI 87
P+ + SP+H AA H +R L+ ++ IT DH++PLH A GH K+
Sbjct: 297 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 356
Query: 88 LLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQ--PESDLASPIHEAARRG 145
LL GA+ N + TPL AC + LLL+ GAS+ ES L +P+H A+ G
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMG 415
Query: 146 HVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLH 204
H+ V +L+ G + + + TPL++A K LL++ A VN + K +PLH
Sbjct: 416 HLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH 475
Query: 205 AVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPESPLAQL--FLEREGA 255
AR + LL++ A+ G P+ + E + + LE+E +
Sbjct: 476 CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Score = 99.0 bits (245), Expect = 4e-21
Identities = 78/240 (32%), Positives = 121/240 (50%), Gaps = 9/240 (3%)
Query: 24 LLSNPLMGDAVSD--WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGH 81
LL N D +S ++P+H AA + + + L+++G +VN + ++PLH A G+
Sbjct: 192 LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN 251
Query: 82 LSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPES-DLASPIHE 140
+ V++LL GAQ+ T D TPL A +G +LL HGA +Q ++ + SPIH
Sbjct: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 311
Query: 141 AARRGHVECVNSLIAYGGNIDH-KISHLGTPLYLACENQQRACVKKLLESGADVN-QGKG 198
AA+ H++CV L+ Y ID + HL TPL++A K LL+ GA N +
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370
Query: 199 QDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVP--PESPLAQLFLEREGAS 256
+PLH + + LL+ GA A G P+ + P+ + L+R GAS
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQR-GAS 429
Score = 94.7 bits (234), Expect = 7e-20
Identities = 58/203 (28%), Positives = 102/203 (50%), Gaps = 2/203 (0%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+H A+ G+ + +R L+ +G + T D ++PLH A GH+ +ILL HGA +
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQPES-DLASPIHEAARRGHVECVNSLIAY 156
T + +P+ A DCV LLLQ+ A + + D +P+H AA GH L+
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 157 GGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ-GKGQDSPLHAVARTASEELA 215
G + + + TPL++AC+ ++ LL++GA ++ + +PLH + +
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 216 CLLMDFGADTQAKNAEGKRPVEL 238
L+ GA N + + P+ +
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHM 443
Score = 84.3 bits (207), Expect = 1e-16
Identities = 63/203 (31%), Positives = 97/203 (47%), Gaps = 2/203 (0%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+H AA GH ++ L+ + + +T +PLH A G + ++LL+ A N
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564
Query: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQ-PESDLASPIHEAARRGHVECVNSLIAY 156
+ TPL A + D V LLL G S P + +P+H AA++ VE SL+ Y
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 157 GGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQG-KGQDSPLHAVARTASEELA 215
GG+ + + TPL+LA + V LL A+ N G K +PLH VA+ +A
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 216 CLLMDFGADTQAKNAEGKRPVEL 238
+L+ G A G P+ +
Sbjct: 685 DVLIKHGVMVDATTRMGYTPLHV 707
Score = 83.2 bits (204), Expect = 2e-16
Identities = 66/230 (28%), Positives = 103/230 (44%), Gaps = 31/230 (13%)
Query: 40 MHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVT 99
+H AA+ G +R L++ G VN + +PL+ A HL VK LL++GA N T
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 100 ADWHTPLFNACVSGSWDCVNLLLQHG---------------------ASV----QPESDL 134
D TPL A G + V L+ +G A+V P D+
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201
Query: 135 AS-----PIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLES 189
S P+H AA ++ L+ G +++ + TPL++A V+ LL+
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261
Query: 190 GADV-NQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVEL 238
GA + + K + +PLH AR ++ +L+D GA QAK G P+ +
Sbjct: 262 GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 311
Score = 81.6 bits (200), Expect = 6e-16
Identities = 64/223 (28%), Positives = 99/223 (44%), Gaps = 4/223 (1%)
Query: 33 AVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHG 92
A D +P+H AA GH ++ L+ N+ T +PLH A GH+ V LL+
Sbjct: 467 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526
Query: 93 AQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPE-SDLASPIHEAARRGHVECVN 151
A +T TPL A G LLL+ A + +P+H A +++ V
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586
Query: 152 SLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQD-SPLHAVARTA 210
L+ GG+ + TPL++A + Q + LL+ G N Q +PLH A+
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG 646
Query: 211 SEELACLLMDFGADTQAKNAEGKRPVELVPPES--PLAQLFLE 251
E+ LL+ A+ N G P+ LV E P+A + ++
Sbjct: 647 HAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Score = 80.5 bits (197), Expect = 1e-15
Identities = 49/144 (34%), Positives = 76/144 (52%), Gaps = 1/144 (0%)
Query: 32 DAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKH 91
++V +P+H AA GH + L+S+ N+ ++PLH GH+ +L+KH
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 92 GAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECV 150
G V+ T +TPL A G+ V LLQH A V ++ L SP+H+AA++GH + V
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
Query: 151 NSLIAYGGNIDHKISHLGTPLYLA 174
L+ G + + S TPL +A
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIA 774
Score = 73.6 bits (179), Expect = 2e-13
Identities = 67/237 (28%), Positives = 104/237 (43%), Gaps = 35/237 (14%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVN 96
++P+H AA +G L+ + N + ++PLH A +L VK+LL G +
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 97 GVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPES-DLASPIHEAARRGHVECVNSLIA 155
+ +TPL A + LLQ+G S ES +P+H AA+ GH E V L++
Sbjct: 597 SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656
Query: 156 --YGGNIDHK---------------------ISH---------LG-TPLYLACENQQRAC 182
GN+ +K I H +G TPL++A
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716
Query: 183 VKKLLESGADVN-QGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVEL 238
VK LL+ ADVN + K SPLH A+ ++ LL+ GA +++G P+ +
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAI 773
Score = 68.9 bits (167), Expect = 4e-12
Identities = 47/177 (26%), Positives = 83/177 (46%), Gaps = 1/177 (0%)
Query: 33 AVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHG 92
A + ++P+H AA R+L+ G + N + V+PLH A GH V +LL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 93 AQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECVN 151
A N TPL G ++L++HG V + + +P+H A+ G+++ V
Sbjct: 659 ANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVK 718
Query: 152 SLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVAR 208
L+ + +++ K +PL+ A + V LL++GA N+ + A+A+
Sbjct: 719 FLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
Score = 66.6 bits (161), Expect = 2e-11
Identities = 59/228 (25%), Positives = 94/228 (41%), Gaps = 31/228 (13%)
Query: 40 MHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVT 99
+H A+ GH + L+ + + T + LH A L G V+ L+ +GA VN +
Sbjct: 49 LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108
Query: 100 ADWHTPLFNACVSGSWDCVNLLLQHGASVQ-PESDLASPIHEAARRGHVECVNSLIAYG- 157
TPL+ A + V LL++GA+ D +P+ A ++GH V LI YG
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT 168
Query: 158 -GNIDHKISHLG---------------------------TPLYLACENQQRACVKKLLES 189
G + H+ TPL++A + + LL
Sbjct: 169 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228
Query: 190 GADVN-QGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPV 236
GA VN + +PLH +R + + LL+D GA + K + P+
Sbjct: 229 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276
Score = 65.1 bits (157), Expect = 6e-11
Identities = 44/120 (36%), Positives = 61/120 (50%), Gaps = 1/120 (0%)
Query: 35 SDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQ 94
S +P+H A GH LI G V+ T +PLH A G++ VK LL+H A
Sbjct: 667 SGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD 726
Query: 95 VNGVTADWHTPLFNACVSGSWDCVNLLLQHGASV-QPESDLASPIHEAARRGHVECVNSL 153
VN T ++PL A G D V LLL++GAS + SD +P+ A R G++ + L
Sbjct: 727 VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 35.0 bits (79), Expect = 0.066
Identities = 34/129 (26%), Positives = 63/129 (48%), Gaps = 4/129 (3%)
Query: 131 ESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLL--E 188
E+D A+ AAR G+++ + G +I+ + L+LA + V +LL E
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
Query: 189 SGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPESPLAQL 248
+ KG ++ LH A +E+ L+++GA+ A++ +G P+ + E+ L +
Sbjct: 69 IILETTTKKG-NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
Query: 249 -FLEREGAS 256
FL GA+
Sbjct: 128 KFLLENGAN 136
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 101 bits (252), Expect = 6e-22
Identities = 72/233 (30%), Positives = 112/233 (48%), Gaps = 6/233 (2%)
Query: 28 PLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKI 87
P+ + SP+H AA H +R L+ ++ IT DH++PLH A GH K+
Sbjct: 297 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 356
Query: 88 LLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQ--PESDLASPIHEAARRG 145
LL GA+ N + TPL AC + LLL+ GAS+ ES L +P+H A+ G
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMG 415
Query: 146 HVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLH 204
H+ V +L+ G + + + TPL++A K LL++ A VN + K +PLH
Sbjct: 416 HLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH 475
Query: 205 AVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPESPLAQL--FLEREGA 255
AR + LL++ A+ G P+ + E + + LE+E +
Sbjct: 476 CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Score = 99.0 bits (245), Expect = 4e-21
Identities = 78/240 (32%), Positives = 121/240 (50%), Gaps = 9/240 (3%)
Query: 24 LLSNPLMGDAVSD--WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGH 81
LL N D +S ++P+H AA + + + L+++G +VN + ++PLH A G+
Sbjct: 192 LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN 251
Query: 82 LSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPES-DLASPIHE 140
+ V++LL GAQ+ T D TPL A +G +LL HGA +Q ++ + SPIH
Sbjct: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 311
Query: 141 AARRGHVECVNSLIAYGGNIDH-KISHLGTPLYLACENQQRACVKKLLESGADVN-QGKG 198
AA+ H++CV L+ Y ID + HL TPL++A K LL+ GA N +
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370
Query: 199 QDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVP--PESPLAQLFLEREGAS 256
+PLH + + LL+ GA A G P+ + P+ + L+R GAS
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQR-GAS 429
Score = 94.7 bits (234), Expect = 7e-20
Identities = 58/203 (28%), Positives = 102/203 (50%), Gaps = 2/203 (0%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+H A+ G+ + +R L+ +G + T D ++PLH A GH+ +ILL HGA +
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQPES-DLASPIHEAARRGHVECVNSLIAY 156
T + +P+ A DCV LLLQ+ A + + D +P+H AA GH L+
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 157 GGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ-GKGQDSPLHAVARTASEELA 215
G + + + TPL++AC+ ++ LL++GA ++ + +PLH + +
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 216 CLLMDFGADTQAKNAEGKRPVEL 238
L+ GA N + + P+ +
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHM 443
Score = 84.3 bits (207), Expect = 1e-16
Identities = 63/203 (31%), Positives = 97/203 (47%), Gaps = 2/203 (0%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+H AA GH ++ L+ + + +T +PLH A G + ++LL+ A N
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564
Query: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQ-PESDLASPIHEAARRGHVECVNSLIAY 156
+ TPL A + D V LLL G S P + +P+H AA++ VE SL+ Y
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 157 GGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQG-KGQDSPLHAVARTASEELA 215
GG+ + + TPL+LA + V LL A+ N G K +PLH VA+ +A
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 216 CLLMDFGADTQAKNAEGKRPVEL 238
+L+ G A G P+ +
Sbjct: 685 DVLIKHGVMVDATTRMGYTPLHV 707
Score = 83.2 bits (204), Expect = 2e-16
Identities = 66/230 (28%), Positives = 103/230 (44%), Gaps = 31/230 (13%)
Query: 40 MHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVT 99
+H AA+ G +R L++ G VN + +PL+ A HL VK LL++GA N T
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 100 ADWHTPLFNACVSGSWDCVNLLLQHG---------------------ASV----QPESDL 134
D TPL A G + V L+ +G A+V P D+
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201
Query: 135 AS-----PIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLES 189
S P+H AA ++ L+ G +++ + TPL++A V+ LL+
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261
Query: 190 GADV-NQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVEL 238
GA + + K + +PLH AR ++ +L+D GA QAK G P+ +
Sbjct: 262 GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 311
Score = 81.6 bits (200), Expect = 6e-16
Identities = 64/223 (28%), Positives = 99/223 (44%), Gaps = 4/223 (1%)
Query: 33 AVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHG 92
A D +P+H AA GH ++ L+ N+ T +PLH A GH+ V LL+
Sbjct: 467 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526
Query: 93 AQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPE-SDLASPIHEAARRGHVECVN 151
A +T TPL A G LLL+ A + +P+H A +++ V
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586
Query: 152 SLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQD-SPLHAVARTA 210
L+ GG+ + TPL++A + Q + LL+ G N Q +PLH A+
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG 646
Query: 211 SEELACLLMDFGADTQAKNAEGKRPVELVPPES--PLAQLFLE 251
E+ LL+ A+ N G P+ LV E P+A + ++
Sbjct: 647 HAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Score = 80.5 bits (197), Expect = 1e-15
Identities = 49/144 (34%), Positives = 76/144 (52%), Gaps = 1/144 (0%)
Query: 32 DAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKH 91
++V +P+H AA GH + L+S+ N+ ++PLH GH+ +L+KH
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 92 GAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECV 150
G V+ T +TPL A G+ V LLQH A V ++ L SP+H+AA++GH + V
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
Query: 151 NSLIAYGGNIDHKISHLGTPLYLA 174
L+ G + + S TPL +A
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIA 774
Score = 73.6 bits (179), Expect = 2e-13
Identities = 67/237 (28%), Positives = 104/237 (43%), Gaps = 35/237 (14%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVN 96
++P+H AA +G L+ + N + ++PLH A +L VK+LL G +
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 97 GVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPES-DLASPIHEAARRGHVECVNSLIA 155
+ +TPL A + LLQ+G S ES +P+H AA+ GH E V L++
Sbjct: 597 SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656
Query: 156 --YGGNIDHK---------------------ISH---------LG-TPLYLACENQQRAC 182
GN+ +K I H +G TPL++A
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716
Query: 183 VKKLLESGADVN-QGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVEL 238
VK LL+ ADVN + K SPLH A+ ++ LL+ GA +++G P+ +
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAI 773
Score = 68.9 bits (167), Expect = 4e-12
Identities = 47/177 (26%), Positives = 83/177 (46%), Gaps = 1/177 (0%)
Query: 33 AVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHG 92
A + ++P+H AA R+L+ G + N + V+PLH A GH V +LL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 93 AQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECVN 151
A N TPL G ++L++HG V + + +P+H A+ G+++ V
Sbjct: 659 ANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVK 718
Query: 152 SLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVAR 208
L+ + +++ K +PL+ A + V LL++GA N+ + A+A+
Sbjct: 719 FLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
Score = 66.6 bits (161), Expect = 2e-11
Identities = 59/228 (25%), Positives = 94/228 (41%), Gaps = 31/228 (13%)
Query: 40 MHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVT 99
+H A+ GH + L+ + + T + LH A L G V+ L+ +GA VN +
Sbjct: 49 LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108
Query: 100 ADWHTPLFNACVSGSWDCVNLLLQHGASVQ-PESDLASPIHEAARRGHVECVNSLIAYG- 157
TPL+ A + V LL++GA+ D +P+ A ++GH V LI YG
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT 168
Query: 158 -GNIDHKISHLG---------------------------TPLYLACENQQRACVKKLLES 189
G + H+ TPL++A + + LL
Sbjct: 169 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228
Query: 190 GADVN-QGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPV 236
GA VN + +PLH +R + + LL+D GA + K + P+
Sbjct: 229 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276
Score = 65.1 bits (157), Expect = 6e-11
Identities = 44/120 (36%), Positives = 61/120 (50%), Gaps = 1/120 (0%)
Query: 35 SDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQ 94
S +P+H A GH LI G V+ T +PLH A G++ VK LL+H A
Sbjct: 667 SGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD 726
Query: 95 VNGVTADWHTPLFNACVSGSWDCVNLLLQHGASV-QPESDLASPIHEAARRGHVECVNSL 153
VN T ++PL A G D V LLL++GAS + SD +P+ A R G++ + L
Sbjct: 727 VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 35.0 bits (79), Expect = 0.066
Identities = 34/129 (26%), Positives = 63/129 (48%), Gaps = 4/129 (3%)
Query: 131 ESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLL--E 188
E+D A+ AAR G+++ + G +I+ + L+LA + V +LL E
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
Query: 189 SGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPESPLAQL 248
+ KG ++ LH A +E+ L+++GA+ A++ +G P+ + E+ L +
Sbjct: 69 IILETTTKKG-NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
Query: 249 -FLEREGAS 256
FL GA+
Sbjct: 128 KFLLENGAN 136
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 101 bits (252), Expect = 6e-22
Identities = 72/233 (30%), Positives = 112/233 (48%), Gaps = 6/233 (2%)
Query: 28 PLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKI 87
P+ + SP+H AA H +R L+ ++ IT DH++PLH A GH K+
Sbjct: 297 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 356
Query: 88 LLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQ--PESDLASPIHEAARRG 145
LL GA+ N + TPL AC + LLL+ GAS+ ES L +P+H A+ G
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMG 415
Query: 146 HVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLH 204
H+ V +L+ G + + + TPL++A K LL++ A VN + K +PLH
Sbjct: 416 HLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH 475
Query: 205 AVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPESPLAQL--FLEREGA 255
AR + LL++ A+ G P+ + E + + LE+E +
Sbjct: 476 CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Score = 99.0 bits (245), Expect = 4e-21
Identities = 78/240 (32%), Positives = 121/240 (50%), Gaps = 9/240 (3%)
Query: 24 LLSNPLMGDAVSD--WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGH 81
LL N D +S ++P+H AA + + + L+++G +VN + ++PLH A G+
Sbjct: 192 LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN 251
Query: 82 LSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPES-DLASPIHE 140
+ V++LL GAQ+ T D TPL A +G +LL HGA +Q ++ + SPIH
Sbjct: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 311
Query: 141 AARRGHVECVNSLIAYGGNIDH-KISHLGTPLYLACENQQRACVKKLLESGADVN-QGKG 198
AA+ H++CV L+ Y ID + HL TPL++A K LL+ GA N +
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370
Query: 199 QDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVP--PESPLAQLFLEREGAS 256
+PLH + + LL+ GA A G P+ + P+ + L+R GAS
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQR-GAS 429
Score = 94.7 bits (234), Expect = 7e-20
Identities = 58/203 (28%), Positives = 102/203 (50%), Gaps = 2/203 (0%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+H A+ G+ + +R L+ +G + T D ++PLH A GH+ +ILL HGA +
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQPES-DLASPIHEAARRGHVECVNSLIAY 156
T + +P+ A DCV LLLQ+ A + + D +P+H AA GH L+
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 157 GGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ-GKGQDSPLHAVARTASEELA 215
G + + + TPL++AC+ ++ LL++GA ++ + +PLH + +
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 216 CLLMDFGADTQAKNAEGKRPVEL 238
L+ GA N + + P+ +
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHM 443
Score = 84.3 bits (207), Expect = 1e-16
Identities = 63/203 (31%), Positives = 97/203 (47%), Gaps = 2/203 (0%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+H AA GH ++ L+ + + +T +PLH A G + ++LL+ A N
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564
Query: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQ-PESDLASPIHEAARRGHVECVNSLIAY 156
+ TPL A + D V LLL G S P + +P+H AA++ VE SL+ Y
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 157 GGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQG-KGQDSPLHAVARTASEELA 215
GG+ + + TPL+LA + V LL A+ N G K +PLH VA+ +A
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 216 CLLMDFGADTQAKNAEGKRPVEL 238
+L+ G A G P+ +
Sbjct: 685 DVLIKHGVMVDATTRMGYTPLHV 707
Score = 83.2 bits (204), Expect = 2e-16
Identities = 66/230 (28%), Positives = 103/230 (44%), Gaps = 31/230 (13%)
Query: 40 MHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVT 99
+H AA+ G +R L++ G VN + +PL+ A HL VK LL++GA N T
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 100 ADWHTPLFNACVSGSWDCVNLLLQHG---------------------ASV----QPESDL 134
D TPL A G + V L+ +G A+V P D+
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201
Query: 135 AS-----PIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLES 189
S P+H AA ++ L+ G +++ + TPL++A V+ LL+
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261
Query: 190 GADV-NQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVEL 238
GA + + K + +PLH AR ++ +L+D GA QAK G P+ +
Sbjct: 262 GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 311
Score = 81.6 bits (200), Expect = 6e-16
Identities = 64/223 (28%), Positives = 99/223 (44%), Gaps = 4/223 (1%)
Query: 33 AVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHG 92
A D +P+H AA GH ++ L+ N+ T +PLH A GH+ V LL+
Sbjct: 467 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526
Query: 93 AQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPE-SDLASPIHEAARRGHVECVN 151
A +T TPL A G LLL+ A + +P+H A +++ V
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586
Query: 152 SLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQD-SPLHAVARTA 210
L+ GG+ + TPL++A + Q + LL+ G N Q +PLH A+
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG 646
Query: 211 SEELACLLMDFGADTQAKNAEGKRPVELVPPES--PLAQLFLE 251
E+ LL+ A+ N G P+ LV E P+A + ++
Sbjct: 647 HAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Score = 80.5 bits (197), Expect = 1e-15
Identities = 49/144 (34%), Positives = 76/144 (52%), Gaps = 1/144 (0%)
Query: 32 DAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKH 91
++V +P+H AA GH + L+S+ N+ ++PLH GH+ +L+KH
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 92 GAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECV 150
G V+ T +TPL A G+ V LLQH A V ++ L SP+H+AA++GH + V
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
Query: 151 NSLIAYGGNIDHKISHLGTPLYLA 174
L+ G + + S TPL +A
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIA 774
Score = 73.6 bits (179), Expect = 2e-13
Identities = 67/237 (28%), Positives = 104/237 (43%), Gaps = 35/237 (14%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVN 96
++P+H AA +G L+ + N + ++PLH A +L VK+LL G +
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 97 GVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPES-DLASPIHEAARRGHVECVNSLIA 155
+ +TPL A + LLQ+G S ES +P+H AA+ GH E V L++
Sbjct: 597 SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656
Query: 156 --YGGNIDHK---------------------ISH---------LG-TPLYLACENQQRAC 182
GN+ +K I H +G TPL++A
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716
Query: 183 VKKLLESGADVN-QGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVEL 238
VK LL+ ADVN + K SPLH A+ ++ LL+ GA +++G P+ +
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAI 773
Score = 68.9 bits (167), Expect = 4e-12
Identities = 47/177 (26%), Positives = 83/177 (46%), Gaps = 1/177 (0%)
Query: 33 AVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHG 92
A + ++P+H AA R+L+ G + N + V+PLH A GH V +LL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 93 AQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECVN 151
A N TPL G ++L++HG V + + +P+H A+ G+++ V
Sbjct: 659 ANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVK 718
Query: 152 SLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVAR 208
L+ + +++ K +PL+ A + V LL++GA N+ + A+A+
Sbjct: 719 FLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
Score = 66.6 bits (161), Expect = 2e-11
Identities = 59/228 (25%), Positives = 94/228 (41%), Gaps = 31/228 (13%)
Query: 40 MHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVT 99
+H A+ GH + L+ + + T + LH A L G V+ L+ +GA VN +
Sbjct: 49 LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108
Query: 100 ADWHTPLFNACVSGSWDCVNLLLQHGASVQ-PESDLASPIHEAARRGHVECVNSLIAYG- 157
TPL+ A + V LL++GA+ D +P+ A ++GH V LI YG
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT 168
Query: 158 -GNIDHKISHLG---------------------------TPLYLACENQQRACVKKLLES 189
G + H+ TPL++A + + LL
Sbjct: 169 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228
Query: 190 GADVN-QGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPV 236
GA VN + +PLH +R + + LL+D GA + K + P+
Sbjct: 229 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276
Score = 65.1 bits (157), Expect = 6e-11
Identities = 44/120 (36%), Positives = 61/120 (50%), Gaps = 1/120 (0%)
Query: 35 SDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQ 94
S +P+H A GH LI G V+ T +PLH A G++ VK LL+H A
Sbjct: 667 SGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD 726
Query: 95 VNGVTADWHTPLFNACVSGSWDCVNLLLQHGASV-QPESDLASPIHEAARRGHVECVNSL 153
VN T ++PL A G D V LLL++GAS + SD +P+ A R G++ + L
Sbjct: 727 VNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 35.0 bits (79), Expect = 0.066
Identities = 34/129 (26%), Positives = 63/129 (48%), Gaps = 4/129 (3%)
Query: 131 ESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLL--E 188
E+D A+ AAR G+++ + G +I+ + L+LA + V +LL E
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
Query: 189 SGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPESPLAQL 248
+ KG ++ LH A +E+ L+++GA+ A++ +G P+ + E+ L +
Sbjct: 69 IILETTTKKG-NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127
Query: 249 -FLEREGAS 256
FL GA+
Sbjct: 128 KFLLENGAN 136
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 101 bits (251), Expect = 8e-22
Identities = 68/204 (33%), Positives = 104/204 (50%), Gaps = 3/204 (1%)
Query: 36 DWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQV 95
D +P+ AA GH ++ L++ VN ++ + L AC GG++ VK+LL+ GA +
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
Query: 96 NGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESD--LASPIHEAARRGHVECVNSL 153
+ HTPL A +G + LLL++GA + S+ S + A +GH+E V L
Sbjct: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420
Query: 154 IAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ-GKGQDSPLHAVARTASE 212
+ G + +HK + T L AC + + LL+SGA VN +SPL A
Sbjct: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480
Query: 213 ELACLLMDFGADTQAKNAEGKRPV 236
ELA LL++ GA + N EG P+
Sbjct: 481 ELAALLIERGASLEEVNDEGYTPL 504
Score = 89.0 bits (219), Expect = 4e-18
Identities = 77/243 (31%), Positives = 111/243 (45%), Gaps = 36/243 (14%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGWAVNIIT-------------------ADHV------- 70
++P+ EAA GH+ + L+ QG +N T AD +
Sbjct: 501 YTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADI 560
Query: 71 -----SPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHG 125
+PL EA GHL VK LL GA V+ TA T L AC +G D ++LLQ G
Sbjct: 561 ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAG 620
Query: 126 ASVQPESDLA-SPIHEAARRGHVECVNSLIAYGGNIDHKISHLG-TPLYLACENQQRACV 183
A ++ ES+ +P+ +AAR GHV V LI+ G N++ ++ T L LAC A V
Sbjct: 621 ADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVV 680
Query: 184 KKLLESGAD-VNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPE 242
+ LL GAD ++ K + L A+ + C L+D+ +A +L PP
Sbjct: 681 ELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDY--PNNLLSAPPPDVTQLTPPS 738
Query: 243 SPL 245
L
Sbjct: 739 HDL 741
Score = 88.6 bits (218), Expect = 5e-18
Identities = 64/201 (31%), Positives = 96/201 (47%), Gaps = 4/201 (1%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
SP+ AA GH LI +G ++ + + +PL EA GH V +LL GA +N
Sbjct: 469 SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA 528
Query: 98 VTAD-WHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAY 156
T + T L AC G + + L++ GA + E ++P+ EAA+ GH+E V L+A
Sbjct: 529 QTEETQETALTLACCGGFLEVADFLIKAGADI--ELGCSTPLMEAAQEGHLELVKYLLAA 586
Query: 157 GGNIDHKISHLGTPLYLACENQQRACVKKLLESGADV-NQGKGQDSPLHAVARTASEELA 215
G N+ + T L ACEN LL++GAD+ ++ +G +PL AR
Sbjct: 587 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTV 646
Query: 216 CLLMDFGADTQAKNAEGKRPV 236
L+ GA+ A V
Sbjct: 647 QFLISKGANVNRTTANNDHTV 667
Score = 81.3 bits (199), Expect = 8e-16
Identities = 55/167 (32%), Positives = 80/167 (47%), Gaps = 5/167 (2%)
Query: 67 ADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGA 126
++H + L AC GGH V+ LL+ GA + TPL A +G V +LL +GA
Sbjct: 1081 SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGA 1140
Query: 127 SVQPESDLA--SPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVK 184
++ +S+ +P+ A G E V L+A G N +H+ TPL LA +K
Sbjct: 1141 DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 1200
Query: 185 KLLESGADVNQGKGQD---SPLHAVARTASEELACLLMDFGADTQAK 228
LL +GA++N G SPL A LL+D G+D A+
Sbjct: 1201 ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQ 1247
Score = 74.3 bits (181), Expect = 1e-13
Identities = 62/201 (30%), Positives = 98/201 (48%), Gaps = 8/201 (3%)
Query: 43 AAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVT-AD 101
A GH+ ++ L+ +G ++ +PL A GH+ V+ILL +GA + +
Sbjct: 1090 ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT 1149
Query: 102 WHTPLFNACVSGSWDCVNLLLQHGASVQPE--SDLASPIHEAARRGHVECVNSLIAYGGN 159
TPL AC G + V LLL GA+ + SD +P+ AA G+V + L+ G
Sbjct: 1150 KDTPLSLACSGGRQEVVELLLARGANKEHRNVSDY-TPLSLAASGGYVNIIKILLNAGAE 1208
Query: 160 IDHKI-SHLG-TPLYLACENQQRACVKKLLESGADVNQ--GKGQDSPLHAVARTASEELA 215
I+ + S LG +PL LA N A VK LL+ G+D+N +++ L E+
Sbjct: 1209 INSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVV 1268
Query: 216 CLLMDFGADTQAKNAEGKRPV 236
LL+D A+ + + G P+
Sbjct: 1269 SLLLDRKANVEHRAKTGLTPL 1289
Score = 72.0 bits (175), Expect = 5e-13
Identities = 59/208 (28%), Positives = 96/208 (46%), Gaps = 7/208 (3%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+ A G Q + L+++G +PL A GG+++ +KILL GA++N
Sbjct: 1152 TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS 1211
Query: 98 VTAD--WHTPLFNACVSGSWDCVNLLLQHGASV--QPESDLASPIHEAARRGHVECVNSL 153
T +PL A ++G V LLL G+ + Q E++ + + A +G E V+ L
Sbjct: 1212 RTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL 1271
Query: 154 IAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ---GKGQDSPLHAVARTA 210
+ N++H+ TPL A + LL+ GADVN +D+ L A
Sbjct: 1272 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1331
Query: 211 SEELACLLMDFGADTQAKNAEGKRPVEL 238
+ LL+ GA +N +G P+ L
Sbjct: 1332 HYKFCELLIGRGAHIDVRNKKGNTPLWL 1359
Score = 69.3 bits (168), Expect = 3e-12
Identities = 60/215 (27%), Positives = 97/215 (45%), Gaps = 40/215 (18%)
Query: 34 VSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADH--VSPLHEACLGGHLSCVKILLKH 91
VSD++P+ AA G+ ++ L++ G +N T +SPL A + GH + VK+LL
Sbjct: 1181 VSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDM 1240
Query: 92 GAQVNG-VTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAAR------ 143
G+ +N + + +T L AC G + V+LLL A+V+ + +P+ EAA
Sbjct: 1241 GSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1300
Query: 144 -----------------------------RGHVECVNSLIAYGGNIDHKISHLGTPLYLA 174
+GH + LI G +ID + TPL+LA
Sbjct: 1301 GRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLA 1360
Query: 175 CENQQRACVKKLLESGADVNQGKGQD-SPLHAVAR 208
V+ L+++GADV+ + +PL A R
Sbjct: 1361 ANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFR 1395
Score = 68.9 bits (167), Expect = 4e-12
Identities = 53/165 (32%), Positives = 83/165 (50%), Gaps = 5/165 (3%)
Query: 73 LHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQP-- 130
L EAC G ++ V+ LL G VN T + + L AC +G ++ +LL A+V+
Sbjct: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 297
Query: 131 -ESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLES 189
+ D+ +P+ AA GHV+ V L+A+ +++ + S T L AC VK LLES
Sbjct: 298 IKGDI-TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES 356
Query: 190 GADV-NQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGK 233
GA + + + +PL E+A LL++ GA + E K
Sbjct: 357 GASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFK 401
Score = 53.1 bits (126), Expect = 2e-07
Identities = 42/117 (35%), Positives = 56/117 (47%), Gaps = 8/117 (6%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITA--DHVSPLHEACLGGHLSCVKILLKHGAQV 95
+P+ +AA GH +++ LIS+G VN TA DH + L AC GGHL+ V++LL HGA
Sbjct: 632 TPLMKAARAGHVCTVQFLISKGANVNRTTANNDH-TVLSLACAGGHLAVVELLLAHGADP 690
Query: 96 NGVTADWHTPLFNACVSGSWDCVNLLLQH-----GASVQPESDLASPIHEAARRGHV 147
D T L A G V LL + A + L P H+ R V
Sbjct: 691 THRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRV 747
Score = 51.6 bits (122), Expect = 7e-07
Identities = 34/112 (30%), Positives = 56/112 (50%), Gaps = 2/112 (1%)
Query: 129 QPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLE 188
Q ES+ + + A GH E V +L+ G +I+H+ TPL LA V+ LL+
Sbjct: 1078 QTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD 1137
Query: 189 SGADV--NQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVEL 238
+GAD+ + +D+PL +E+ LL+ GA+ + +N P+ L
Sbjct: 1138 NGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSL 1189
Score = 51.6 bits (122), Expect = 7e-07
Identities = 41/148 (27%), Positives = 67/148 (45%), Gaps = 6/148 (4%)
Query: 70 VSPLHEACLGGHLSCVKILLKHGAQVNG--VTADWHTPLFNACVSGSWDCVNLLLQHGAS 127
++PL EA GG+ ++LL GA VN V + T L A G + LL+ GA
Sbjct: 1286 LTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAH 1345
Query: 128 VQPESDLAS-PIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKL 186
+ + + P+ AA GH++ V L+ G ++D + TPL A V+ L
Sbjct: 1346 IDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYL 1405
Query: 187 LESGADVNQGKGQDSPLHAVARTASEEL 214
++ +VNQ + +A +E+
Sbjct: 1406 VK---EVNQFPSDSECMRYIATITDKEM 1430
Score = 37.4 bits (85), Expect = 0.013
Identities = 32/117 (27%), Positives = 52/117 (44%), Gaps = 6/117 (5%)
Query: 43 AAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADW 102
AA GH LI +G +++ +PL A GGHL V++L++ GA V+
Sbjct: 1327 AADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1386
Query: 103 HTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPI-----HEAARRGHVECVNSLI 154
TPL A G V L++ +S+ I E ++ H+ C+ S++
Sbjct: 1387 ITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHL-CMESIV 1442
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 101 bits (251), Expect = 8e-22
Identities = 68/204 (33%), Positives = 104/204 (50%), Gaps = 3/204 (1%)
Query: 36 DWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQV 95
D +P+ AA GH ++ L++ VN ++ + L AC GG++ VK+LL+ GA +
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
Query: 96 NGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESD--LASPIHEAARRGHVECVNSL 153
+ HTPL A +G + LLL++GA + S+ S + A +GH+E V L
Sbjct: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420
Query: 154 IAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ-GKGQDSPLHAVARTASE 212
+ G + +HK + T L AC + + LL+SGA VN +SPL A
Sbjct: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480
Query: 213 ELACLLMDFGADTQAKNAEGKRPV 236
ELA LL++ GA + N EG P+
Sbjct: 481 ELAALLIERGASLEEVNDEGYTPL 504
Score = 89.0 bits (219), Expect = 4e-18
Identities = 77/243 (31%), Positives = 111/243 (45%), Gaps = 36/243 (14%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGWAVNIIT-------------------ADHV------- 70
++P+ EAA GH+ + L+ QG +N T AD +
Sbjct: 501 YTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADI 560
Query: 71 -----SPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHG 125
+PL EA GHL VK LL GA V+ TA T L AC +G D ++LLQ G
Sbjct: 561 ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAG 620
Query: 126 ASVQPESDLA-SPIHEAARRGHVECVNSLIAYGGNIDHKISHLG-TPLYLACENQQRACV 183
A ++ ES+ +P+ +AAR GHV V LI+ G N++ ++ T L LAC A V
Sbjct: 621 ADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVV 680
Query: 184 KKLLESGAD-VNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPE 242
+ LL GAD ++ K + L A+ + C L+D+ +A +L PP
Sbjct: 681 ELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDY--PNNLLSAPPPDVTQLTPPS 738
Query: 243 SPL 245
L
Sbjct: 739 HDL 741
Score = 88.6 bits (218), Expect = 5e-18
Identities = 64/201 (31%), Positives = 96/201 (47%), Gaps = 4/201 (1%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
SP+ AA GH LI +G ++ + + +PL EA GH V +LL GA +N
Sbjct: 469 SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA 528
Query: 98 VTAD-WHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAY 156
T + T L AC G + + L++ GA + E ++P+ EAA+ GH+E V L+A
Sbjct: 529 QTEETQETALTLACCGGFLEVADFLIKAGADI--ELGCSTPLMEAAQEGHLELVKYLLAA 586
Query: 157 GGNIDHKISHLGTPLYLACENQQRACVKKLLESGADV-NQGKGQDSPLHAVARTASEELA 215
G N+ + T L ACEN LL++GAD+ ++ +G +PL AR
Sbjct: 587 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTV 646
Query: 216 CLLMDFGADTQAKNAEGKRPV 236
L+ GA+ A V
Sbjct: 647 QFLISKGANVNRTTANNDHTV 667
Score = 81.3 bits (199), Expect = 8e-16
Identities = 55/167 (32%), Positives = 80/167 (47%), Gaps = 5/167 (2%)
Query: 67 ADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGA 126
++H + L AC GGH V+ LL+ GA + TPL A +G V +LL +GA
Sbjct: 830 SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGA 889
Query: 127 SVQPESDLA--SPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVK 184
++ +S+ +P+ A G E V L+A G N +H+ TPL LA +K
Sbjct: 890 DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 949
Query: 185 KLLESGADVNQGKGQD---SPLHAVARTASEELACLLMDFGADTQAK 228
LL +GA++N G SPL A LL+D G+D A+
Sbjct: 950 ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQ 996
Score = 74.3 bits (181), Expect = 1e-13
Identities = 62/201 (30%), Positives = 98/201 (48%), Gaps = 8/201 (3%)
Query: 43 AAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVT-AD 101
A GH+ ++ L+ +G ++ +PL A GH+ V+ILL +GA + +
Sbjct: 839 ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT 898
Query: 102 WHTPLFNACVSGSWDCVNLLLQHGASVQPE--SDLASPIHEAARRGHVECVNSLIAYGGN 159
TPL AC G + V LLL GA+ + SD +P+ AA G+V + L+ G
Sbjct: 899 KDTPLSLACSGGRQEVVELLLARGANKEHRNVSDY-TPLSLAASGGYVNIIKILLNAGAE 957
Query: 160 IDHKI-SHLG-TPLYLACENQQRACVKKLLESGADVNQ--GKGQDSPLHAVARTASEELA 215
I+ + S LG +PL LA N A VK LL+ G+D+N +++ L E+
Sbjct: 958 INSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVV 1017
Query: 216 CLLMDFGADTQAKNAEGKRPV 236
LL+D A+ + + G P+
Sbjct: 1018 SLLLDRKANVEHRAKTGLTPL 1038
Score = 72.0 bits (175), Expect = 5e-13
Identities = 59/208 (28%), Positives = 96/208 (46%), Gaps = 7/208 (3%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+ A G Q + L+++G +PL A GG+++ +KILL GA++N
Sbjct: 901 TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS 960
Query: 98 VTAD--WHTPLFNACVSGSWDCVNLLLQHGASV--QPESDLASPIHEAARRGHVECVNSL 153
T +PL A ++G V LLL G+ + Q E++ + + A +G E V+ L
Sbjct: 961 RTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL 1020
Query: 154 IAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ---GKGQDSPLHAVARTA 210
+ N++H+ TPL A + LL+ GADVN +D+ L A
Sbjct: 1021 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1080
Query: 211 SEELACLLMDFGADTQAKNAEGKRPVEL 238
+ LL+ GA +N +G P+ L
Sbjct: 1081 HYKFCELLIGRGAHIDVRNKKGNTPLWL 1108
Score = 69.3 bits (168), Expect = 3e-12
Identities = 60/215 (27%), Positives = 97/215 (45%), Gaps = 40/215 (18%)
Query: 34 VSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADH--VSPLHEACLGGHLSCVKILLKH 91
VSD++P+ AA G+ ++ L++ G +N T +SPL A + GH + VK+LL
Sbjct: 930 VSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDM 989
Query: 92 GAQVNG-VTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAAR------ 143
G+ +N + + +T L AC G + V+LLL A+V+ + +P+ EAA
Sbjct: 990 GSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1049
Query: 144 -----------------------------RGHVECVNSLIAYGGNIDHKISHLGTPLYLA 174
+GH + LI G +ID + TPL+LA
Sbjct: 1050 GRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLA 1109
Query: 175 CENQQRACVKKLLESGADVNQGKGQD-SPLHAVAR 208
V+ L+++GADV+ + +PL A R
Sbjct: 1110 ANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFR 1144
Score = 68.9 bits (167), Expect = 4e-12
Identities = 53/165 (32%), Positives = 83/165 (50%), Gaps = 5/165 (3%)
Query: 73 LHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQP-- 130
L EAC G ++ V+ LL G VN T + + L AC +G ++ +LL A+V+
Sbjct: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 297
Query: 131 -ESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLES 189
+ D+ +P+ AA GHV+ V L+A+ +++ + S T L AC VK LLES
Sbjct: 298 IKGDI-TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES 356
Query: 190 GADV-NQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGK 233
GA + + + +PL E+A LL++ GA + E K
Sbjct: 357 GASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFK 401
Score = 53.1 bits (126), Expect = 2e-07
Identities = 42/117 (35%), Positives = 56/117 (47%), Gaps = 8/117 (6%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITA--DHVSPLHEACLGGHLSCVKILLKHGAQV 95
+P+ +AA GH +++ LIS+G VN TA DH + L AC GGHL+ V++LL HGA
Sbjct: 632 TPLMKAARAGHVCTVQFLISKGANVNRTTANNDH-TVLSLACAGGHLAVVELLLAHGADP 690
Query: 96 NGVTADWHTPLFNACVSGSWDCVNLLLQH-----GASVQPESDLASPIHEAARRGHV 147
D T L A G V LL + A + L P H+ R V
Sbjct: 691 THRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRV 747
Score = 51.6 bits (122), Expect = 7e-07
Identities = 34/112 (30%), Positives = 56/112 (50%), Gaps = 2/112 (1%)
Query: 129 QPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLE 188
Q ES+ + + A GH E V +L+ G +I+H+ TPL LA V+ LL+
Sbjct: 827 QTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD 886
Query: 189 SGADV--NQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVEL 238
+GAD+ + +D+PL +E+ LL+ GA+ + +N P+ L
Sbjct: 887 NGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSL 938
Score = 51.6 bits (122), Expect = 7e-07
Identities = 41/148 (27%), Positives = 67/148 (45%), Gaps = 6/148 (4%)
Query: 70 VSPLHEACLGGHLSCVKILLKHGAQVNG--VTADWHTPLFNACVSGSWDCVNLLLQHGAS 127
++PL EA GG+ ++LL GA VN V + T L A G + LL+ GA
Sbjct: 1035 LTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAH 1094
Query: 128 VQPESDLAS-PIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKL 186
+ + + P+ AA GH++ V L+ G ++D + TPL A V+ L
Sbjct: 1095 IDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYL 1154
Query: 187 LESGADVNQGKGQDSPLHAVARTASEEL 214
++ +VNQ + +A +E+
Sbjct: 1155 VK---EVNQFPSDSECMRYIATITDKEM 1179
Score = 37.4 bits (85), Expect = 0.013
Identities = 32/117 (27%), Positives = 52/117 (44%), Gaps = 6/117 (5%)
Query: 43 AAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADW 102
AA GH LI +G +++ +PL A GGHL V++L++ GA V+
Sbjct: 1076 AADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1135
Query: 103 HTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPI-----HEAARRGHVECVNSLI 154
TPL A G V L++ +S+ I E ++ H+ C+ S++
Sbjct: 1136 ITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHL-CMESIV 1191
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 97.4 bits (241), Expect = 1e-20
Identities = 66/204 (32%), Positives = 101/204 (49%), Gaps = 3/204 (1%)
Query: 36 DWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQV 95
D +P+ A+ G+ ++ L+ VN +A + L AC GG + VK+LL GA +
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
Query: 96 NGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESD--LASPIHEAARRGHVECVNSL 153
+ HTPL A +G + +LL HGA + S+ S + A +GH++ V L
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391
Query: 154 IAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ-GKGQDSPLHAVARTASE 212
+ G + +HK + T L AC + + LL+SGA VN +SPL A
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451
Query: 213 ELACLLMDFGADTQAKNAEGKRPV 236
ELA LL++ GA+ + N EG P+
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPL 475
Score = 80.9 bits (198), Expect = 1e-15
Identities = 54/170 (31%), Positives = 85/170 (50%), Gaps = 3/170 (1%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
SP+ AA GH LI +G + + + +PL EA GH V +LL GA +N
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
Query: 98 VTAD-WHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAY 156
T + T L AC G + + L++ GA + E ++P+ EA++ GH+E V L+A
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAGADI--ELGCSTPLMEASQEGHLELVKYLLAS 557
Query: 157 GGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAV 206
G N+ + T L ACEN LL++GAD+++ + + L +
Sbjct: 558 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGI 607
Score = 63.2 bits (152), Expect = 2e-10
Identities = 46/164 (28%), Positives = 80/164 (48%), Gaps = 3/164 (1%)
Query: 73 LHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPES 132
L EAC G ++ V+ LL G VN T + + L AC +G ++ +LL A+V+
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
Query: 133 DLA--SPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESG 190
+ +P+ A+ G+++ V L+ + +++ + + T L AC VK LL G
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 191 ADV-NQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGK 233
A++ + + +PL A E+A +L+D GA + E K
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFK 372
Score = 55.1 bits (131), Expect = 6e-08
Identities = 41/129 (31%), Positives = 58/129 (44%), Gaps = 31/129 (24%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGWAVNIIT-------------------ADHV------- 70
++P+ EAA GH+ + L++QG +N T AD +
Sbjct: 472 YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI 531
Query: 71 -----SPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHG 125
+PL EA GHL VK LL GA V+ TA T L AC +G D ++LLQ G
Sbjct: 532 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
Query: 126 ASVQPESDL 134
A + + D+
Sbjct: 592 ADLDKQEDM 600
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 97.4 bits (241), Expect = 1e-20
Identities = 66/204 (32%), Positives = 101/204 (49%), Gaps = 3/204 (1%)
Query: 36 DWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQV 95
D +P+ A+ G+ ++ L+ VN +A + L AC GG + VK+LL GA +
Sbjct: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
Query: 96 NGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESD--LASPIHEAARRGHVECVNSL 153
+ HTPL A +G + +LL HGA + S+ S + A +GH++ V L
Sbjct: 321 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 380
Query: 154 IAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ-GKGQDSPLHAVARTASE 212
+ G + +HK + T L AC + + LL+SGA VN +SPL A
Sbjct: 381 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 440
Query: 213 ELACLLMDFGADTQAKNAEGKRPV 236
ELA LL++ GA+ + N EG P+
Sbjct: 441 ELAALLIERGANLEEVNDEGYTPL 464
Score = 80.9 bits (198), Expect = 1e-15
Identities = 54/170 (31%), Positives = 85/170 (50%), Gaps = 3/170 (1%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
SP+ AA GH LI +G + + + +PL EA GH V +LL GA +N
Sbjct: 429 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 488
Query: 98 VTAD-WHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAY 156
T + T L AC G + + L++ GA + E ++P+ EA++ GH+E V L+A
Sbjct: 489 QTEETQETALTLACCGGFSEVADFLIKAGADI--ELGCSTPLMEASQEGHLELVKYLLAS 546
Query: 157 GGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAV 206
G N+ + T L ACEN LL++GAD+++ + + L +
Sbjct: 547 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGI 596
Score = 63.2 bits (152), Expect = 2e-10
Identities = 46/164 (28%), Positives = 80/164 (48%), Gaps = 3/164 (1%)
Query: 73 LHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPES 132
L EAC G ++ V+ LL G VN T + + L AC +G ++ +LL A+V+
Sbjct: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 257
Query: 133 DLA--SPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESG 190
+ +P+ A+ G+++ V L+ + +++ + + T L AC VK LL G
Sbjct: 258 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317
Query: 191 ADV-NQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGK 233
A++ + + +PL A E+A +L+D GA + E K
Sbjct: 318 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFK 361
Score = 55.1 bits (131), Expect = 6e-08
Identities = 41/129 (31%), Positives = 58/129 (44%), Gaps = 31/129 (24%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGWAVNIIT-------------------ADHV------- 70
++P+ EAA GH+ + L++QG +N T AD +
Sbjct: 461 YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI 520
Query: 71 -----SPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHG 125
+PL EA GHL VK LL GA V+ TA T L AC +G D ++LLQ G
Sbjct: 521 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 580
Query: 126 ASVQPESDL 134
A + + D+
Sbjct: 581 ADLDKQEDM 589
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 97.4 bits (241), Expect = 1e-20
Identities = 66/204 (32%), Positives = 101/204 (49%), Gaps = 3/204 (1%)
Query: 36 DWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQV 95
D +P+ A+ G+ ++ L+ VN +A + L AC GG + VK+LL GA +
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
Query: 96 NGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESD--LASPIHEAARRGHVECVNSL 153
+ HTPL A +G + +LL HGA + S+ S + A +GH++ V L
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391
Query: 154 IAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ-GKGQDSPLHAVARTASE 212
+ G + +HK + T L AC + + LL+SGA VN +SPL A
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451
Query: 213 ELACLLMDFGADTQAKNAEGKRPV 236
ELA LL++ GA+ + N EG P+
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPL 475
Score = 85.9 bits (211), Expect = 3e-17
Identities = 63/201 (31%), Positives = 95/201 (47%), Gaps = 4/201 (1%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
SP+ AA GH LI +G + + + +PL EA GH V +LL GA +N
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
Query: 98 VTAD-WHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAY 156
T + T L AC G + + L++ GA + E ++P+ EA++ GH+E V L+A
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAGADI--ELGCSTPLMEASQEGHLELVKYLLAS 557
Query: 157 GGNIDHKISHLGTPLYLACENQQRACVKKLLESGADV-NQGKGQDSPLHAVARTASEELA 215
G N+ + T L ACEN LL++GAD+ ++ +G +PL AR
Sbjct: 558 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTV 617
Query: 216 CLLMDFGADTQAKNAEGKRPV 236
L+ GA+ A V
Sbjct: 618 QFLISKGANVNRATANNDHTV 638
Score = 82.4 bits (202), Expect = 4e-16
Identities = 69/219 (31%), Positives = 104/219 (47%), Gaps = 34/219 (15%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGWAVNIIT-------------------ADHV------- 70
++P+ EAA GH+ + L++QG +N T AD +
Sbjct: 472 YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI 531
Query: 71 -----SPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHG 125
+PL EA GHL VK LL GA V+ TA T L AC +G D ++LLQ G
Sbjct: 532 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
Query: 126 ASVQPESDLA-SPIHEAARRGHVECVNSLIAYGGNIDHKISHLG-TPLYLACENQQRACV 183
A ++ ES+ +P+ +AAR GH+ V LI+ G N++ ++ T + LAC A V
Sbjct: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVV 651
Query: 184 KKLLESGAD-VNQGKGQDSPLHAVARTASEELACLLMDF 221
+ LL GAD ++ K + L A+ + L+D+
Sbjct: 652 ELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 76.3 bits (186), Expect = 3e-14
Identities = 52/167 (31%), Positives = 78/167 (46%), Gaps = 5/167 (2%)
Query: 67 ADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGA 126
++H + L AC GGH V +L+ A++ TPL A +G V +LL G
Sbjct: 1053 SNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGG 1112
Query: 127 SVQPESDLA--SPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVK 184
++ +S+ +P+ A G E V+ L+A G N +H+ TPL LA +K
Sbjct: 1113 DIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 1172
Query: 185 KLLESGADVNQGKGQD---SPLHAVARTASEELACLLMDFGADTQAK 228
LL +GA++N G SPL A LL+D G+D A+
Sbjct: 1173 ILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQ 1219
Score = 71.2 bits (173), Expect = 8e-13
Identities = 59/208 (28%), Positives = 96/208 (46%), Gaps = 7/208 (3%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+ A G Q + L+++G +PL A GG+++ +KILL GA++N
Sbjct: 1124 TPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS 1183
Query: 98 VTAD--WHTPLFNACVSGSWDCVNLLLQHGASV--QPESDLASPIHEAARRGHVECVNSL 153
T +PL A ++G V LLL G+ + Q E++ + + A +G E V+ L
Sbjct: 1184 RTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLL 1243
Query: 154 IAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ---GKGQDSPLHAVARTA 210
+ N++H+ TPL A + LL+ GADVN +D+ L A
Sbjct: 1244 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1303
Query: 211 SEELACLLMDFGADTQAKNAEGKRPVEL 238
+ LL+ GA +N +G P+ L
Sbjct: 1304 HYKFCELLIHRGAHIDVRNKKGNTPLWL 1331
Score = 66.6 bits (161), Expect = 2e-11
Identities = 55/200 (27%), Positives = 94/200 (47%), Gaps = 39/200 (19%)
Query: 34 VSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADH--VSPLHEACLGGHLSCVKILLKH 91
VSD++P+ AA G+ ++ L++ G +N T +SPL A + GH+ VK+LL
Sbjct: 1153 VSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDM 1212
Query: 92 GAQVNG-VTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVEC 149
G+ +N + + +T L AC G + V+LLL A+V+ + +P+ EAA G+ E
Sbjct: 1213 GSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1272
Query: 150 VNSLIAYGGNID----------------------------HKISHL-------GTPLYLA 174
L+ G +++ H+ +H+ TPL+LA
Sbjct: 1273 GRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLA 1332
Query: 175 CENQQRACVKKLLESGADVN 194
V+ L+++GADV+
Sbjct: 1333 SNGGHFDVVQLLVQAGADVD 1352
Score = 65.5 bits (158), Expect = 5e-11
Identities = 60/201 (29%), Positives = 94/201 (46%), Gaps = 8/201 (3%)
Query: 43 AAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVT-AD 101
A GH+ + LI++ + +PL A GH+ V+ILL G + +
Sbjct: 1062 ACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERT 1121
Query: 102 WHTPLFNACVSGSWDCVNLLLQHGASVQPE--SDLASPIHEAARRGHVECVNSLIAYGGN 159
TPL AC G + V+LLL GA+ + SD +P+ AA G+V + L+ G
Sbjct: 1122 KDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDY-TPLSLAASGGYVNIIKILLNAGAE 1180
Query: 160 IDHKI-SHLG-TPLYLACENQQRACVKKLLESGADVNQ--GKGQDSPLHAVARTASEELA 215
I+ + S LG +PL LA N VK LL+ G+D+N +++ L E+
Sbjct: 1181 INSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVV 1240
Query: 216 CLLMDFGADTQAKNAEGKRPV 236
LL+D A+ + + G P+
Sbjct: 1241 SLLLDRKANVEHRAKTGLTPL 1261
Score = 63.2 bits (152), Expect = 2e-10
Identities = 46/164 (28%), Positives = 80/164 (48%), Gaps = 3/164 (1%)
Query: 73 LHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPES 132
L EAC G ++ V+ LL G VN T + + L AC +G ++ +LL A+V+
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
Query: 133 DLA--SPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESG 190
+ +P+ A+ G+++ V L+ + +++ + + T L AC VK LL G
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 191 ADV-NQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGK 233
A++ + + +PL A E+A +L+D GA + E K
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFK 372
Score = 61.2 bits (147), Expect = 9e-10
Identities = 66/248 (26%), Positives = 103/248 (41%), Gaps = 31/248 (12%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+ EA+ GH ++ L++ G V+ TA + L AC GH +LL+ GA +
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
Query: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQ--PESDLASPIHEAARRGHVECVNSLIA 155
+ TPL A +G V L+ GA+V ++ + + A GH+ V L+A
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656
Query: 156 YGGNIDHKISHLGTPLYLACENQQRACVKKLLE--------SGADVNQ--GKGQDS---- 201
+G + H++ T L A + V LL+ DV+Q QD
Sbjct: 657 HGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVP 716
Query: 202 --PLHAVA---------RTASEELACLL-MDFGADTQAKNAEGKRPVELVP---PESPLA 246
P H +A RT+ E LL + G Q ++ +L+P P PL
Sbjct: 717 RVPTHTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPSFHPYQPLE 776
Query: 247 QLFLEREG 254
+ E EG
Sbjct: 777 CIVEETEG 784
Score = 49.3 bits (116), Expect = 3e-06
Identities = 41/148 (27%), Positives = 66/148 (44%), Gaps = 6/148 (4%)
Query: 70 VSPLHEACLGGHLSCVKILLKHGAQVNG--VTADWHTPLFNACVSGSWDCVNLLLQHGAS 127
++PL EA GG+ ++LL GA VN V + T L A G + LL+ GA
Sbjct: 1258 LTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAH 1317
Query: 128 VQPESDLAS-PIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKL 186
+ + + P+ A+ GH + V L+ G ++D + TPL A V+ L
Sbjct: 1318 IDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYL 1377
Query: 187 LESGADVNQGKGQDSPLHAVARTASEEL 214
++ +VNQ + +A +EL
Sbjct: 1378 VK---EVNQFPSDIECMRYIATITDKEL 1402
Score = 47.4 bits (111), Expect = 1e-05
Identities = 33/110 (30%), Positives = 52/110 (47%), Gaps = 2/110 (1%)
Query: 131 ESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESG 190
ES+ + + A GH E V+ LIA I+H+ TPL LA V+ LL+ G
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
Query: 191 ADV--NQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVEL 238
D+ + +D+PL +E+ LL+ GA+ + +N P+ L
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSL 1161
Score = 35.8 bits (81), Expect = 0.039
Identities = 25/81 (30%), Positives = 38/81 (46%)
Query: 43 AAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADW 102
AA GH LI +G +++ +PL A GGH V++L++ GA V+
Sbjct: 1299 AADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRK 1358
Query: 103 HTPLFNACVSGSWDCVNLLLQ 123
TPL +A G V L++
Sbjct: 1359 ITPLMSAFRKGHVKVVQYLVK 1379
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 97.4 bits (241), Expect = 1e-20
Identities = 66/204 (32%), Positives = 101/204 (49%), Gaps = 3/204 (1%)
Query: 36 DWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQV 95
D +P+ A+ G+ ++ L+ VN +A + L AC GG + VK+LL GA +
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
Query: 96 NGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESD--LASPIHEAARRGHVECVNSL 153
+ HTPL A +G + +LL HGA + S+ S + A +GH++ V L
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391
Query: 154 IAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ-GKGQDSPLHAVARTASE 212
+ G + +HK + T L AC + + LL+SGA VN +SPL A
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451
Query: 213 ELACLLMDFGADTQAKNAEGKRPV 236
ELA LL++ GA+ + N EG P+
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPL 475
Score = 85.9 bits (211), Expect = 3e-17
Identities = 63/201 (31%), Positives = 95/201 (47%), Gaps = 4/201 (1%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
SP+ AA GH LI +G + + + +PL EA GH V +LL GA +N
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
Query: 98 VTAD-WHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAY 156
T + T L AC G + + L++ GA + E ++P+ EA++ GH+E V L+A
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAGADI--ELGCSTPLMEASQEGHLELVKYLLAS 557
Query: 157 GGNIDHKISHLGTPLYLACENQQRACVKKLLESGADV-NQGKGQDSPLHAVARTASEELA 215
G N+ + T L ACEN LL++GAD+ ++ +G +PL AR
Sbjct: 558 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTV 617
Query: 216 CLLMDFGADTQAKNAEGKRPV 236
L+ GA+ A V
Sbjct: 618 QFLISKGANVNRATANNDHTV 638
Score = 82.4 bits (202), Expect = 4e-16
Identities = 69/219 (31%), Positives = 104/219 (47%), Gaps = 34/219 (15%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGWAVNIIT-------------------ADHV------- 70
++P+ EAA GH+ + L++QG +N T AD +
Sbjct: 472 YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI 531
Query: 71 -----SPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHG 125
+PL EA GHL VK LL GA V+ TA T L AC +G D ++LLQ G
Sbjct: 532 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
Query: 126 ASVQPESDLA-SPIHEAARRGHVECVNSLIAYGGNIDHKISHLG-TPLYLACENQQRACV 183
A ++ ES+ +P+ +AAR GH+ V LI+ G N++ ++ T + LAC A V
Sbjct: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVV 651
Query: 184 KKLLESGAD-VNQGKGQDSPLHAVARTASEELACLLMDF 221
+ LL GAD ++ K + L A+ + L+D+
Sbjct: 652 ELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 76.3 bits (186), Expect = 3e-14
Identities = 52/167 (31%), Positives = 78/167 (46%), Gaps = 5/167 (2%)
Query: 67 ADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGA 126
++H + L AC GGH V +L+ A++ TPL A +G V +LL G
Sbjct: 1053 SNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGG 1112
Query: 127 SVQPESDLA--SPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVK 184
++ +S+ +P+ A G E V+ L+A G N +H+ TPL LA +K
Sbjct: 1113 DIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 1172
Query: 185 KLLESGADVNQGKGQD---SPLHAVARTASEELACLLMDFGADTQAK 228
LL +GA++N G SPL A LL+D G+D A+
Sbjct: 1173 ILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQ 1219
Score = 71.2 bits (173), Expect = 8e-13
Identities = 59/208 (28%), Positives = 96/208 (46%), Gaps = 7/208 (3%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+ A G Q + L+++G +PL A GG+++ +KILL GA++N
Sbjct: 1124 TPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS 1183
Query: 98 VTAD--WHTPLFNACVSGSWDCVNLLLQHGASV--QPESDLASPIHEAARRGHVECVNSL 153
T +PL A ++G V LLL G+ + Q E++ + + A +G E V+ L
Sbjct: 1184 RTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLL 1243
Query: 154 IAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ---GKGQDSPLHAVARTA 210
+ N++H+ TPL A + LL+ GADVN +D+ L A
Sbjct: 1244 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1303
Query: 211 SEELACLLMDFGADTQAKNAEGKRPVEL 238
+ LL+ GA +N +G P+ L
Sbjct: 1304 HYKFCELLIHRGAHIDVRNKKGNTPLWL 1331
Score = 66.6 bits (161), Expect = 2e-11
Identities = 55/200 (27%), Positives = 94/200 (47%), Gaps = 39/200 (19%)
Query: 34 VSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADH--VSPLHEACLGGHLSCVKILLKH 91
VSD++P+ AA G+ ++ L++ G +N T +SPL A + GH+ VK+LL
Sbjct: 1153 VSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDM 1212
Query: 92 GAQVNG-VTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVEC 149
G+ +N + + +T L AC G + V+LLL A+V+ + +P+ EAA G+ E
Sbjct: 1213 GSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1272
Query: 150 VNSLIAYGGNID----------------------------HKISHL-------GTPLYLA 174
L+ G +++ H+ +H+ TPL+LA
Sbjct: 1273 GRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLA 1332
Query: 175 CENQQRACVKKLLESGADVN 194
V+ L+++GADV+
Sbjct: 1333 SNGGHFDVVQLLVQAGADVD 1352
Score = 65.5 bits (158), Expect = 5e-11
Identities = 60/201 (29%), Positives = 94/201 (46%), Gaps = 8/201 (3%)
Query: 43 AAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVT-AD 101
A GH+ + LI++ + +PL A GH+ V+ILL G + +
Sbjct: 1062 ACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERT 1121
Query: 102 WHTPLFNACVSGSWDCVNLLLQHGASVQPE--SDLASPIHEAARRGHVECVNSLIAYGGN 159
TPL AC G + V+LLL GA+ + SD +P+ AA G+V + L+ G
Sbjct: 1122 KDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDY-TPLSLAASGGYVNIIKILLNAGAE 1180
Query: 160 IDHKI-SHLG-TPLYLACENQQRACVKKLLESGADVNQ--GKGQDSPLHAVARTASEELA 215
I+ + S LG +PL LA N VK LL+ G+D+N +++ L E+
Sbjct: 1181 INSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVV 1240
Query: 216 CLLMDFGADTQAKNAEGKRPV 236
LL+D A+ + + G P+
Sbjct: 1241 SLLLDRKANVEHRAKTGLTPL 1261
Score = 63.2 bits (152), Expect = 2e-10
Identities = 46/164 (28%), Positives = 80/164 (48%), Gaps = 3/164 (1%)
Query: 73 LHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPES 132
L EAC G ++ V+ LL G VN T + + L AC +G ++ +LL A+V+
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
Query: 133 DLA--SPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESG 190
+ +P+ A+ G+++ V L+ + +++ + + T L AC VK LL G
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 191 ADV-NQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGK 233
A++ + + +PL A E+A +L+D GA + E K
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFK 372
Score = 61.2 bits (147), Expect = 9e-10
Identities = 66/248 (26%), Positives = 103/248 (41%), Gaps = 31/248 (12%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+ EA+ GH ++ L++ G V+ TA + L AC GH +LL+ GA +
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
Query: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQ--PESDLASPIHEAARRGHVECVNSLIA 155
+ TPL A +G V L+ GA+V ++ + + A GH+ V L+A
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656
Query: 156 YGGNIDHKISHLGTPLYLACENQQRACVKKLLE--------SGADVNQ--GKGQDS---- 201
+G + H++ T L A + V LL+ DV+Q QD
Sbjct: 657 HGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVP 716
Query: 202 --PLHAVA---------RTASEELACLL-MDFGADTQAKNAEGKRPVELVP---PESPLA 246
P H +A RT+ E LL + G Q ++ +L+P P PL
Sbjct: 717 RVPTHTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPSFHPYQPLE 776
Query: 247 QLFLEREG 254
+ E EG
Sbjct: 777 CIVEETEG 784
Score = 49.3 bits (116), Expect = 3e-06
Identities = 41/148 (27%), Positives = 66/148 (44%), Gaps = 6/148 (4%)
Query: 70 VSPLHEACLGGHLSCVKILLKHGAQVNG--VTADWHTPLFNACVSGSWDCVNLLLQHGAS 127
++PL EA GG+ ++LL GA VN V + T L A G + LL+ GA
Sbjct: 1258 LTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAH 1317
Query: 128 VQPESDLAS-PIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKL 186
+ + + P+ A+ GH + V L+ G ++D + TPL A V+ L
Sbjct: 1318 IDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYL 1377
Query: 187 LESGADVNQGKGQDSPLHAVARTASEEL 214
++ +VNQ + +A +EL
Sbjct: 1378 VK---EVNQFPSDIECMRYIATITDKEL 1402
Score = 47.4 bits (111), Expect = 1e-05
Identities = 33/110 (30%), Positives = 52/110 (47%), Gaps = 2/110 (1%)
Query: 131 ESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESG 190
ES+ + + A GH E V+ LIA I+H+ TPL LA V+ LL+ G
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
Query: 191 ADV--NQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVEL 238
D+ + +D+PL +E+ LL+ GA+ + +N P+ L
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSL 1161
Score = 35.8 bits (81), Expect = 0.039
Identities = 25/81 (30%), Positives = 38/81 (46%)
Query: 43 AAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADW 102
AA GH LI +G +++ +PL A GGH V++L++ GA V+
Sbjct: 1299 AADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRK 1358
Query: 103 HTPLFNACVSGSWDCVNLLLQ 123
TPL +A G V L++
Sbjct: 1359 ITPLMSAFRKGHVKVVQYLVK 1379
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 96.7 bits (239), Expect = 2e-20
Identities = 66/206 (32%), Positives = 105/206 (50%), Gaps = 2/206 (0%)
Query: 35 SDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQ 94
S ++P+H AA +G+ L+++G AV+ + ++PLH A G+ + VK+LL G Q
Sbjct: 211 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 270
Query: 95 VNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPES-DLASPIHEAARRGHVECVNSL 153
++ T D TPL A SG V LLL+ GA + + + SP+H AA+ HVECV L
Sbjct: 271 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 330
Query: 154 IAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAVARTASE 212
+ + +D T L++A K LL+ A+ N + +PLH +
Sbjct: 331 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRI 390
Query: 213 ELACLLMDFGADTQAKNAEGKRPVEL 238
++ LL+ +GA QA G P+ +
Sbjct: 391 KVMELLVKYGASIQAITESGLTPIHV 416
Score = 94.7 bits (234), Expect = 7e-20
Identities = 73/233 (31%), Positives = 112/233 (48%), Gaps = 6/233 (2%)
Query: 28 PLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKI 87
PL+ + SP+H AA H +++L+ V+ +T D+++ LH A GH K+
Sbjct: 303 PLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKL 362
Query: 88 LLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQ--PESDLASPIHEAARRG 145
LL A N + TPL AC + LL+++GAS+Q ES L +PIH AA G
Sbjct: 363 LLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGL-TPIHVAAFMG 421
Query: 146 HVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLH 204
H+ V L+ G + D T L++A Q V+ LL +GA V+ + + + +PLH
Sbjct: 422 HLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLH 481
Query: 205 AVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPES--PLAQLFLEREGA 255
+R E+ LL+ A A G P+ + E +A + LE A
Sbjct: 482 IASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 534
Score = 82.8 bits (203), Expect = 3e-16
Identities = 63/198 (31%), Positives = 93/198 (46%), Gaps = 4/198 (2%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+H AA + +Q L+ +G + + + +PLH A + LL +GA+ N
Sbjct: 577 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 636
Query: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASV--QPESDLASPIHEAARRGHVECVNSLIA 155
VT TPL A G D V LLL GA++ +S L S +H AA+ V + L
Sbjct: 637 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTS-LHLAAQEDKVNVADILTK 695
Query: 156 YGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAVARTASEEL 214
+G + D TPL +AC V LL+ GA+VN + K +PLH A+ +
Sbjct: 696 HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHI 755
Query: 215 ACLLMDFGADTQAKNAEG 232
+L+ GA A A G
Sbjct: 756 INVLLQHGAKPNATTANG 773
Score = 78.6 bits (192), Expect = 5e-15
Identities = 52/177 (29%), Positives = 83/177 (46%), Gaps = 1/177 (0%)
Query: 33 AVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHG 92
A + ++P+H AA L++ G NI+T V+PLH A GH V +LL G
Sbjct: 605 AKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG 664
Query: 93 AQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECVN 151
A ++ T T L A + ++L +HGA + L +P+ A G+V+ VN
Sbjct: 665 ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVN 724
Query: 152 SLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVAR 208
L+ G N++ K + TPL+ A + + LL+ GA N + A+A+
Sbjct: 725 FLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 781
Score = 75.9 bits (185), Expect = 3e-14
Identities = 58/199 (29%), Positives = 96/199 (48%), Gaps = 3/199 (1%)
Query: 62 VNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLL 121
VN T +PLH A G+++ +LL GA V+ + TPL A G+ + V LL
Sbjct: 205 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 264
Query: 122 LQHGASVQPES-DLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQR 180
L G + ++ D +P+H AAR GH + V L+ G + + + +PL++A +
Sbjct: 265 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV 324
Query: 181 ACVKKLLESGADVNQ-GKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELV 239
CVK LL+ A V+ + LH A + LL+D A+ A+ G P+ +
Sbjct: 325 ECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIA 384
Query: 240 PPESPLAQL-FLEREGASL 257
++ + + L + GAS+
Sbjct: 385 CKKNRIKVMELLVKYGASI 403
Score = 74.7 bits (182), Expect = 8e-14
Identities = 61/224 (27%), Positives = 104/224 (46%), Gaps = 3/224 (1%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVN 96
++P+H +A G L+ G A ++ T +PLH A G L K+LL+ A +
Sbjct: 510 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 569
Query: 97 GVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECVNSLIA 155
+ TPL A + LLL+ GAS + +P+H AA++ ++ ++L+
Sbjct: 570 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 629
Query: 156 YGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQG-KGQDSPLHAVARTASEEL 214
YG + TPL+LA + V LL+ GA+++ K + LH A+ +
Sbjct: 630 YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 689
Query: 215 ACLLMDFGADTQAKNAEGKRPVELVPPESPLAQL-FLEREGASL 257
A +L GAD A G P+ + + + FL ++GA++
Sbjct: 690 ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 733
Score = 72.8 bits (177), Expect = 3e-13
Identities = 66/263 (25%), Positives = 107/263 (40%), Gaps = 41/263 (15%)
Query: 40 MHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVT 99
+H AA GH ++ L+ +G +V+ T + LH A L G VK+L+K GA +N +
Sbjct: 47 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 106
Query: 100 ADWHTPLFNACVSGSWDCVNLLLQHGASVQPES-DLASPIHEAARRGHVECVNSLIAYG- 157
+ TPL+ A D V LL++GA+ + D +P+ A ++GH + V L+
Sbjct: 107 QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT 166
Query: 158 -GNIDHKISHLG-----------------------------------TPLYLACENQQRA 181
G + H+ TPL++A
Sbjct: 167 KGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVN 226
Query: 182 CVKKLLESGADVN-QGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELV- 239
LL GA V+ + +PLH ++ + + LL+D G AK +G P+
Sbjct: 227 VATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAA 286
Query: 240 -PPESPLAQLFLEREGASLPKPK 261
+ +L LER L + K
Sbjct: 287 RSGHDQVVELLLERGAPLLARTK 309
Score = 72.4 bits (176), Expect = 4e-13
Identities = 55/189 (29%), Positives = 91/189 (48%), Gaps = 6/189 (3%)
Query: 43 AAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADW 102
AA G+ + + G +N + ++ LH A GH+ V+ LL G+ V+ T
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 103 HTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECVNSLIAYGGNID 161
+T L A ++G + V +L++ GA++ +S +P++ AA+ H++ V L+ G N
Sbjct: 77 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 136
Query: 162 HKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLM-- 219
TPL +A + V LLE+ +GK + LH AR + A LL+
Sbjct: 137 TATEDGFTPLAVALQQGHNQAVAILLEND---TKGKVRLPALHIAARKDDTKSAALLLQN 193
Query: 220 DFGADTQAK 228
D AD Q+K
Sbjct: 194 DHNADVQSK 202
Score = 70.1 bits (170), Expect = 2e-12
Identities = 60/223 (26%), Positives = 98/223 (43%), Gaps = 4/223 (1%)
Query: 24 LLSNPLMGDAVS--DWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGH 81
LL N + DA + + +P+H A+ G ++ L+ + T + +PLH + G
Sbjct: 462 LLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQ 521
Query: 82 LSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPE-SDLASPIHE 140
+ +LL+ GA + T TPL A GS D LLLQ A+ + +P+H
Sbjct: 522 VDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHV 581
Query: 141 AARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQD 200
AA + + L+ G + + TPL++A + Q LL GA+ N Q
Sbjct: 582 AAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQG 641
Query: 201 -SPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPE 242
+PLH ++ ++ LL+D GA+ G + L E
Sbjct: 642 VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQE 684
Score = 65.9 bits (159), Expect = 4e-11
Identities = 61/214 (28%), Positives = 96/214 (44%), Gaps = 18/214 (8%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVN 96
++P++ AA H ++ L+ G + T D +PL A GH V ILL+ N
Sbjct: 110 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE-----N 164
Query: 97 GVTADWHTP-LFNACVSGSWDCVNLLLQ--HGASVQPESDL-------ASPIHEAARRGH 146
P L A LLLQ H A VQ + + +P+H AA G+
Sbjct: 165 DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGN 224
Query: 147 VECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQD--SPLH 204
V L+ G +D + TPL++A + VK LL+ G ++ K +D +PLH
Sbjct: 225 VNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQID-AKTRDGLTPLH 283
Query: 205 AVARTASEELACLLMDFGADTQAKNAEGKRPVEL 238
AR+ +++ LL++ GA A+ G P+ +
Sbjct: 284 CAARSGHDQVVELLLERGAPLLARTKNGLSPLHM 317
Score = 28.5 bits (62), Expect = 6.2
Identities = 17/52 (32%), Positives = 27/52 (51%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKIL 88
++P+H+AA GH + L+ G N TA+ + L A G++S V L
Sbjct: 741 YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 96.7 bits (239), Expect = 2e-20
Identities = 66/206 (32%), Positives = 105/206 (50%), Gaps = 2/206 (0%)
Query: 35 SDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQ 94
S ++P+H AA +G+ L+++G AV+ + ++PLH A G+ + VK+LL G Q
Sbjct: 232 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 291
Query: 95 VNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPES-DLASPIHEAARRGHVECVNSL 153
++ T D TPL A SG V LLL+ GA + + + SP+H AA+ HVECV L
Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 351
Query: 154 IAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAVARTASE 212
+ + +D T L++A K LL+ A+ N + +PLH +
Sbjct: 352 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRI 411
Query: 213 ELACLLMDFGADTQAKNAEGKRPVEL 238
++ LL+ +GA QA G P+ +
Sbjct: 412 KVMELLVKYGASIQAITESGLTPIHV 437
Score = 94.7 bits (234), Expect = 7e-20
Identities = 73/233 (31%), Positives = 112/233 (48%), Gaps = 6/233 (2%)
Query: 28 PLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKI 87
PL+ + SP+H AA H +++L+ V+ +T D+++ LH A GH K+
Sbjct: 324 PLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKL 383
Query: 88 LLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQ--PESDLASPIHEAARRG 145
LL A N + TPL AC + LL+++GAS+Q ES L +PIH AA G
Sbjct: 384 LLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGL-TPIHVAAFMG 442
Query: 146 HVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLH 204
H+ V L+ G + D T L++A Q V+ LL +GA V+ + + + +PLH
Sbjct: 443 HLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLH 502
Query: 205 AVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPES--PLAQLFLEREGA 255
+R E+ LL+ A A G P+ + E +A + LE A
Sbjct: 503 IASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555
Score = 82.8 bits (203), Expect = 3e-16
Identities = 63/198 (31%), Positives = 93/198 (46%), Gaps = 4/198 (2%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+H AA + +Q L+ +G + + + +PLH A + LL +GA+ N
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657
Query: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASV--QPESDLASPIHEAARRGHVECVNSLIA 155
VT TPL A G D V LLL GA++ +S L S +H AA+ V + L
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTS-LHLAAQEDKVNVADILTK 716
Query: 156 YGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAVARTASEEL 214
+G + D TPL +AC V LL+ GA+VN + K +PLH A+ +
Sbjct: 717 HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHI 776
Query: 215 ACLLMDFGADTQAKNAEG 232
+L+ GA A A G
Sbjct: 777 INVLLQHGAKPNATTANG 794
Score = 78.6 bits (192), Expect = 5e-15
Identities = 52/177 (29%), Positives = 83/177 (46%), Gaps = 1/177 (0%)
Query: 33 AVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHG 92
A + ++P+H AA L++ G NI+T V+PLH A GH V +LL G
Sbjct: 626 AKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG 685
Query: 93 AQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECVN 151
A ++ T T L A + ++L +HGA + L +P+ A G+V+ VN
Sbjct: 686 ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVN 745
Query: 152 SLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVAR 208
L+ G N++ K + TPL+ A + + LL+ GA N + A+A+
Sbjct: 746 FLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802
Score = 75.9 bits (185), Expect = 3e-14
Identities = 58/199 (29%), Positives = 96/199 (48%), Gaps = 3/199 (1%)
Query: 62 VNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLL 121
VN T +PLH A G+++ +LL GA V+ + TPL A G+ + V LL
Sbjct: 226 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285
Query: 122 LQHGASVQPES-DLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQR 180
L G + ++ D +P+H AAR GH + V L+ G + + + +PL++A +
Sbjct: 286 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV 345
Query: 181 ACVKKLLESGADVNQ-GKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELV 239
CVK LL+ A V+ + LH A + LL+D A+ A+ G P+ +
Sbjct: 346 ECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIA 405
Query: 240 PPESPLAQL-FLEREGASL 257
++ + + L + GAS+
Sbjct: 406 CKKNRIKVMELLVKYGASI 424
Score = 74.7 bits (182), Expect = 8e-14
Identities = 61/224 (27%), Positives = 104/224 (46%), Gaps = 3/224 (1%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVN 96
++P+H +A G L+ G A ++ T +PLH A G L K+LL+ A +
Sbjct: 531 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 590
Query: 97 GVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECVNSLIA 155
+ TPL A + LLL+ GAS + +P+H AA++ ++ ++L+
Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 650
Query: 156 YGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQG-KGQDSPLHAVARTASEEL 214
YG + TPL+LA + V LL+ GA+++ K + LH A+ +
Sbjct: 651 YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 710
Query: 215 ACLLMDFGADTQAKNAEGKRPVELVPPESPLAQL-FLEREGASL 257
A +L GAD A G P+ + + + FL ++GA++
Sbjct: 711 ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 754
Score = 72.8 bits (177), Expect = 3e-13
Identities = 66/263 (25%), Positives = 107/263 (40%), Gaps = 41/263 (15%)
Query: 40 MHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVT 99
+H AA GH ++ L+ +G +V+ T + LH A L G VK+L+K GA +N +
Sbjct: 68 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 127
Query: 100 ADWHTPLFNACVSGSWDCVNLLLQHGASVQPES-DLASPIHEAARRGHVECVNSLIAYG- 157
+ TPL+ A D V LL++GA+ + D +P+ A ++GH + V L+
Sbjct: 128 QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT 187
Query: 158 -GNIDHKISHLG-----------------------------------TPLYLACENQQRA 181
G + H+ TPL++A
Sbjct: 188 KGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVN 247
Query: 182 CVKKLLESGADVN-QGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELV- 239
LL GA V+ + +PLH ++ + + LL+D G AK +G P+
Sbjct: 248 VATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAA 307
Query: 240 -PPESPLAQLFLEREGASLPKPK 261
+ +L LER L + K
Sbjct: 308 RSGHDQVVELLLERGAPLLARTK 330
Score = 72.4 bits (176), Expect = 4e-13
Identities = 55/189 (29%), Positives = 91/189 (48%), Gaps = 6/189 (3%)
Query: 43 AAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADW 102
AA G+ + + G +N + ++ LH A GH+ V+ LL G+ V+ T
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 103 HTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECVNSLIAYGGNID 161
+T L A ++G + V +L++ GA++ +S +P++ AA+ H++ V L+ G N
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157
Query: 162 HKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLM-- 219
TPL +A + V LLE+ +GK + LH AR + A LL+
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAILLEND---TKGKVRLPALHIAARKDDTKSAALLLQN 214
Query: 220 DFGADTQAK 228
D AD Q+K
Sbjct: 215 DHNADVQSK 223
Score = 70.1 bits (170), Expect = 2e-12
Identities = 60/223 (26%), Positives = 98/223 (43%), Gaps = 4/223 (1%)
Query: 24 LLSNPLMGDAVS--DWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGH 81
LL N + DA + + +P+H A+ G ++ L+ + T + +PLH + G
Sbjct: 483 LLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQ 542
Query: 82 LSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPE-SDLASPIHE 140
+ +LL+ GA + T TPL A GS D LLLQ A+ + +P+H
Sbjct: 543 VDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHV 602
Query: 141 AARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQD 200
AA + + L+ G + + TPL++A + Q LL GA+ N Q
Sbjct: 603 AAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQG 662
Query: 201 -SPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPE 242
+PLH ++ ++ LL+D GA+ G + L E
Sbjct: 663 VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQE 705
Score = 65.9 bits (159), Expect = 4e-11
Identities = 61/214 (28%), Positives = 96/214 (44%), Gaps = 18/214 (8%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVN 96
++P++ AA H ++ L+ G + T D +PL A GH V ILL+ N
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE-----N 185
Query: 97 GVTADWHTP-LFNACVSGSWDCVNLLLQ--HGASVQPESDL-------ASPIHEAARRGH 146
P L A LLLQ H A VQ + + +P+H AA G+
Sbjct: 186 DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGN 245
Query: 147 VECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQD--SPLH 204
V L+ G +D + TPL++A + VK LL+ G ++ K +D +PLH
Sbjct: 246 VNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQID-AKTRDGLTPLH 304
Query: 205 AVARTASEELACLLMDFGADTQAKNAEGKRPVEL 238
AR+ +++ LL++ GA A+ G P+ +
Sbjct: 305 CAARSGHDQVVELLLERGAPLLARTKNGLSPLHM 338
Score = 28.5 bits (62), Expect = 6.2
Identities = 17/52 (32%), Positives = 27/52 (51%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKIL 88
++P+H+AA GH + L+ G N TA+ + L A G++S V L
Sbjct: 762 YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 96.7 bits (239), Expect = 2e-20
Identities = 66/206 (32%), Positives = 105/206 (50%), Gaps = 2/206 (0%)
Query: 35 SDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQ 94
S ++P+H AA +G+ L+++G AV+ + ++PLH A G+ + VK+LL G Q
Sbjct: 232 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 291
Query: 95 VNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPES-DLASPIHEAARRGHVECVNSL 153
++ T D TPL A SG V LLL+ GA + + + SP+H AA+ HVECV L
Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 351
Query: 154 IAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAVARTASE 212
+ + +D T L++A K LL+ A+ N + +PLH +
Sbjct: 352 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRI 411
Query: 213 ELACLLMDFGADTQAKNAEGKRPVEL 238
++ LL+ +GA QA G P+ +
Sbjct: 412 KVMELLVKYGASIQAITESGLTPIHV 437
Score = 94.7 bits (234), Expect = 7e-20
Identities = 73/233 (31%), Positives = 112/233 (48%), Gaps = 6/233 (2%)
Query: 28 PLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKI 87
PL+ + SP+H AA H +++L+ V+ +T D+++ LH A GH K+
Sbjct: 324 PLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKL 383
Query: 88 LLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQ--PESDLASPIHEAARRG 145
LL A N + TPL AC + LL+++GAS+Q ES L +PIH AA G
Sbjct: 384 LLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGL-TPIHVAAFMG 442
Query: 146 HVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLH 204
H+ V L+ G + D T L++A Q V+ LL +GA V+ + + + +PLH
Sbjct: 443 HLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLH 502
Query: 205 AVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPES--PLAQLFLEREGA 255
+R E+ LL+ A A G P+ + E +A + LE A
Sbjct: 503 IASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555
Score = 82.8 bits (203), Expect = 3e-16
Identities = 63/198 (31%), Positives = 93/198 (46%), Gaps = 4/198 (2%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+H AA + +Q L+ +G + + + +PLH A + LL +GA+ N
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657
Query: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASV--QPESDLASPIHEAARRGHVECVNSLIA 155
VT TPL A G D V LLL GA++ +S L S +H AA+ V + L
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTS-LHLAAQEDKVNVADILTK 716
Query: 156 YGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAVARTASEEL 214
+G + D TPL +AC V LL+ GA+VN + K +PLH A+ +
Sbjct: 717 HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHI 776
Query: 215 ACLLMDFGADTQAKNAEG 232
+L+ GA A A G
Sbjct: 777 INVLLQHGAKPNATTANG 794
Score = 78.6 bits (192), Expect = 5e-15
Identities = 52/177 (29%), Positives = 83/177 (46%), Gaps = 1/177 (0%)
Query: 33 AVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHG 92
A + ++P+H AA L++ G NI+T V+PLH A GH V +LL G
Sbjct: 626 AKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG 685
Query: 93 AQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECVN 151
A ++ T T L A + ++L +HGA + L +P+ A G+V+ VN
Sbjct: 686 ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVN 745
Query: 152 SLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVAR 208
L+ G N++ K + TPL+ A + + LL+ GA N + A+A+
Sbjct: 746 FLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802
Score = 75.9 bits (185), Expect = 3e-14
Identities = 58/199 (29%), Positives = 96/199 (48%), Gaps = 3/199 (1%)
Query: 62 VNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLL 121
VN T +PLH A G+++ +LL GA V+ + TPL A G+ + V LL
Sbjct: 226 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285
Query: 122 LQHGASVQPES-DLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQR 180
L G + ++ D +P+H AAR GH + V L+ G + + + +PL++A +
Sbjct: 286 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV 345
Query: 181 ACVKKLLESGADVNQ-GKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELV 239
CVK LL+ A V+ + LH A + LL+D A+ A+ G P+ +
Sbjct: 346 ECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIA 405
Query: 240 PPESPLAQL-FLEREGASL 257
++ + + L + GAS+
Sbjct: 406 CKKNRIKVMELLVKYGASI 424
Score = 74.7 bits (182), Expect = 8e-14
Identities = 61/224 (27%), Positives = 104/224 (46%), Gaps = 3/224 (1%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVN 96
++P+H +A G L+ G A ++ T +PLH A G L K+LL+ A +
Sbjct: 531 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 590
Query: 97 GVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECVNSLIA 155
+ TPL A + LLL+ GAS + +P+H AA++ ++ ++L+
Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 650
Query: 156 YGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQG-KGQDSPLHAVARTASEEL 214
YG + TPL+LA + V LL+ GA+++ K + LH A+ +
Sbjct: 651 YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 710
Query: 215 ACLLMDFGADTQAKNAEGKRPVELVPPESPLAQL-FLEREGASL 257
A +L GAD A G P+ + + + FL ++GA++
Sbjct: 711 ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 754
Score = 72.8 bits (177), Expect = 3e-13
Identities = 66/263 (25%), Positives = 107/263 (40%), Gaps = 41/263 (15%)
Query: 40 MHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVT 99
+H AA GH ++ L+ +G +V+ T + LH A L G VK+L+K GA +N +
Sbjct: 68 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 127
Query: 100 ADWHTPLFNACVSGSWDCVNLLLQHGASVQPES-DLASPIHEAARRGHVECVNSLIAYG- 157
+ TPL+ A D V LL++GA+ + D +P+ A ++GH + V L+
Sbjct: 128 QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT 187
Query: 158 -GNIDHKISHLG-----------------------------------TPLYLACENQQRA 181
G + H+ TPL++A
Sbjct: 188 KGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVN 247
Query: 182 CVKKLLESGADVN-QGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELV- 239
LL GA V+ + +PLH ++ + + LL+D G AK +G P+
Sbjct: 248 VATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAA 307
Query: 240 -PPESPLAQLFLEREGASLPKPK 261
+ +L LER L + K
Sbjct: 308 RSGHDQVVELLLERGAPLLARTK 330
Score = 72.4 bits (176), Expect = 4e-13
Identities = 55/189 (29%), Positives = 91/189 (48%), Gaps = 6/189 (3%)
Query: 43 AAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADW 102
AA G+ + + G +N + ++ LH A GH+ V+ LL G+ V+ T
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 103 HTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECVNSLIAYGGNID 161
+T L A ++G + V +L++ GA++ +S +P++ AA+ H++ V L+ G N
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157
Query: 162 HKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLM-- 219
TPL +A + V LLE+ +GK + LH AR + A LL+
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAILLEND---TKGKVRLPALHIAARKDDTKSAALLLQN 214
Query: 220 DFGADTQAK 228
D AD Q+K
Sbjct: 215 DHNADVQSK 223
Score = 70.1 bits (170), Expect = 2e-12
Identities = 60/223 (26%), Positives = 98/223 (43%), Gaps = 4/223 (1%)
Query: 24 LLSNPLMGDAVS--DWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGH 81
LL N + DA + + +P+H A+ G ++ L+ + T + +PLH + G
Sbjct: 483 LLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQ 542
Query: 82 LSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPE-SDLASPIHE 140
+ +LL+ GA + T TPL A GS D LLLQ A+ + +P+H
Sbjct: 543 VDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHV 602
Query: 141 AARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQD 200
AA + + L+ G + + TPL++A + Q LL GA+ N Q
Sbjct: 603 AAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQG 662
Query: 201 -SPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPE 242
+PLH ++ ++ LL+D GA+ G + L E
Sbjct: 663 VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQE 705
Score = 65.9 bits (159), Expect = 4e-11
Identities = 61/214 (28%), Positives = 96/214 (44%), Gaps = 18/214 (8%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVN 96
++P++ AA H ++ L+ G + T D +PL A GH V ILL+ N
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE-----N 185
Query: 97 GVTADWHTP-LFNACVSGSWDCVNLLLQ--HGASVQPESDL-------ASPIHEAARRGH 146
P L A LLLQ H A VQ + + +P+H AA G+
Sbjct: 186 DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGN 245
Query: 147 VECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQD--SPLH 204
V L+ G +D + TPL++A + VK LL+ G ++ K +D +PLH
Sbjct: 246 VNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQID-AKTRDGLTPLH 304
Query: 205 AVARTASEELACLLMDFGADTQAKNAEGKRPVEL 238
AR+ +++ LL++ GA A+ G P+ +
Sbjct: 305 CAARSGHDQVVELLLERGAPLLARTKNGLSPLHM 338
Score = 28.5 bits (62), Expect = 6.2
Identities = 17/52 (32%), Positives = 27/52 (51%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKIL 88
++P+H+AA GH + L+ G N TA+ + L A G++S V L
Sbjct: 762 YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
a [Homo sapiens]
Length = 518
Score = 95.5 bits (236), Expect = 4e-20
Identities = 70/224 (31%), Positives = 103/224 (45%), Gaps = 41/224 (18%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGWAVNII---TADHVSPLHEACLGGHLSCVKILLKHGA 93
W P+HEAA H L+ LI+ + N I T + LH A GH V+ILL+ GA
Sbjct: 44 WMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGA 103
Query: 94 QVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA------------------ 135
N T + TPLF A +G D + LLLQHGA+V +
Sbjct: 104 DPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIK 163
Query: 136 -----------------SPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQ 178
+P+ AA+ G +E ++ LI+ G N++ + TPL++A +
Sbjct: 164 LLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEG 223
Query: 179 QRACVKKLLESGADVNQGKGQDS---PLHAVARTASEELACLLM 219
CV+ LL SGAD + +DS P+HA A+ ++ LL+
Sbjct: 224 HTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLI 267
Score = 55.8 bits (133), Expect = 4e-08
Identities = 47/176 (26%), Positives = 81/176 (46%), Gaps = 6/176 (3%)
Query: 67 ADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGA 126
AD S + A G++ ++ LLK G V+ P+ A S +C+ +L+ +
Sbjct: 8 ADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADS 67
Query: 127 S----VQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRAC 182
S + +H AA +GH + V L+ G + + TPL+LA EN Q
Sbjct: 68 SENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDV 127
Query: 183 VKKLLESGADVNQGKGQD--SPLHAVARTASEELACLLMDFGADTQAKNAEGKRPV 236
++ LL+ GA+VN + LH + + E+ LL+ GA+ + ++ G P+
Sbjct: 128 LRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPL 183
Score = 48.5 bits (114), Expect = 6e-06
Identities = 45/165 (27%), Positives = 68/165 (41%), Gaps = 41/165 (24%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQ--- 94
+P+ AA +G SL LIS G VN D +PL A GH CV++LL GA
Sbjct: 181 TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 240
Query: 95 ----------VNGVTADWHT----------------------PLFNACVSGSWDCVNLLL 122
++ HT P+++A G DC+ +LL
Sbjct: 241 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 300
Query: 123 QHGASVQPESDL----ASPIHEAARRG--HVECVNSLIAYGGNID 161
++G S ++ L +SP+ A ++ VN L+ YG I+
Sbjct: 301 RNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN 345
Score = 38.5 bits (88), Expect = 0.006
Identities = 27/111 (24%), Positives = 51/111 (45%), Gaps = 4/111 (3%)
Query: 132 SDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGA 191
+D S + AAR G+V+ + L+ G ++D + P++ A + C++ L+ + +
Sbjct: 8 ADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADS 67
Query: 192 DVNQGKGQD----SPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVEL 238
N K + LH A ++ +L++ GAD A E P+ L
Sbjct: 68 SENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFL 118
Score = 32.0 bits (71), Expect = 0.56
Identities = 27/120 (22%), Positives = 45/120 (37%), Gaps = 15/120 (12%)
Query: 25 LSNPLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSC 84
L+N ++ SP++ A GH+ L L+ G++ + C+ C
Sbjct: 269 LTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDC 328
Query: 85 -----VKILLKHGAQVNGVTADWHTP----------LFNACVSGSWDCVNLLLQHGASVQ 129
V ILLK+GAQ+N + + L C G W+ + + H Q
Sbjct: 329 EFFGIVNILLKYGAQINELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQ 388
>gi|24586688 ankyrin repeat and SOCS box-containing protein 16 [Homo
sapiens]
Length = 453
Score = 94.4 bits (233), Expect = 9e-20
Identities = 65/211 (30%), Positives = 101/211 (47%), Gaps = 12/211 (5%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+ A G+ R+LI QG ++ + LHEAC CV++LL GA+ N
Sbjct: 113 APLAIATARGYTDCARHLIRQGAELDARVGGRAA-LHEACARAQFDCVRLLLTFGAKANV 171
Query: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQ--PESDLASPIHEAARRGHVECVNSLIA 155
+T + TPL + S C LLL+ GA+V +P+H AA RG + V +
Sbjct: 172 LTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLE 231
Query: 156 YGGNIDHKISHLGTPLYLACE--------NQQRACVKKLLESGADVN-QGKGQDSPLHAV 206
+G ++ + S T L AC + +A ++LLE+GAD G+ + +PLH
Sbjct: 232 HGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNA 291
Query: 207 ARTASEELACLLMDFGADTQAKNAEGKRPVE 237
LA LL+ +GA + N G P++
Sbjct: 292 CANGCGGLAELLLRYGARAEVPNGAGHTPMD 322
Score = 58.9 bits (141), Expect = 4e-09
Identities = 45/195 (23%), Positives = 75/195 (38%), Gaps = 45/195 (23%)
Query: 73 LHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPES 132
+H+A G+L V+ L + N + L + G W + P++
Sbjct: 61 VHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFW-----------VLTPKT 109
Query: 133 DLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLG------------------------ 168
+P+ A RG+ +C LI G +D ++
Sbjct: 110 KQTAPLAIATARGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKA 169
Query: 169 --------TPLYLACENQQRACVKKLLESGADVN--QGKGQDSPLHAVARTASEELACLL 218
TPL+L + C K LLE+GA VN G+ Q++PLH A E+ L
Sbjct: 170 NVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALY 229
Query: 219 MDFGADTQAKNAEGK 233
++ GAD + ++G+
Sbjct: 230 LEHGADVGLRTSQGE 244
Score = 50.4 bits (119), Expect = 2e-06
Identities = 31/103 (30%), Positives = 47/103 (45%), Gaps = 8/103 (7%)
Query: 35 SDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGG--------HLSCVK 86
S +P+H AA G + + + G V + T+ + L+ AC G H + +
Sbjct: 209 SQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAAR 268
Query: 87 ILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQ 129
LL+ GA HTPL NAC +G LLL++GA +
Sbjct: 269 RLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAE 311
Score = 40.8 bits (94), Expect = 0.001
Identities = 25/84 (29%), Positives = 37/84 (44%), Gaps = 2/84 (2%)
Query: 170 PLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKN 229
PL +A C + L+ GA+++ G + LH A + LL+ FGA
Sbjct: 114 PLAIATARGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLT 173
Query: 230 AEGKRPVEL--VPPESPLAQLFLE 251
EG P+ L +P A+L LE
Sbjct: 174 EEGTTPLHLCTIPESLQCAKLLLE 197
>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
sapiens]
Length = 587
Score = 93.6 bits (231), Expect = 2e-19
Identities = 57/206 (27%), Positives = 105/206 (50%), Gaps = 5/206 (2%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGW--AVNIITADHVSPLHEACLGGHLSCVKILLKHGAQ 94
W P+HEAA +G Q+ ++ + + ++ T + ++ A GHL C+ LL+ GA+
Sbjct: 91 WLPLHEAAYYG-QVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAE 149
Query: 95 VNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGHVECVNSL 153
+ TPL+ AC + + V +L+QH A + + +HE+ R +E + L
Sbjct: 150 PDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQIL 209
Query: 154 IAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAVARTASE 212
++ G ++ K ++ TPL++A ++ Q ++ L + GAD+N Q S L+ + E
Sbjct: 210 VSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHE 269
Query: 213 ELACLLMDFGADTQAKNAEGKRPVEL 238
E+ L+ GAD N +G P+ +
Sbjct: 270 EVVEFLLSQGADANKTNKDGLLPLHI 295
Score = 76.3 bits (186), Expect = 3e-14
Identities = 59/199 (29%), Positives = 88/199 (44%), Gaps = 11/199 (5%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+ AA G +LR L G +N +D+ S L+EAC H V+ LL GA N
Sbjct: 225 TPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANK 284
Query: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYG 157
D PL A G++ V +LL + + SP+H AA R H E + +L++
Sbjct: 285 TNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSAR 344
Query: 158 GNIDHKIS---------HLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVAR 208
+++ ++ + LY A N + LL+ GAD N + SPL R
Sbjct: 345 FDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPN--RDVISPLLVAIR 402
Query: 209 TASEELACLLMDFGADTQA 227
LL+D GA+ A
Sbjct: 403 HGCLRTMQLLLDHGANIDA 421
Score = 69.7 bits (169), Expect = 2e-12
Identities = 54/190 (28%), Positives = 84/190 (44%), Gaps = 4/190 (2%)
Query: 72 PLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQH--GASVQ 129
PL +A G +K ++K G + + PL A G C+ +L + G Q
Sbjct: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
Query: 130 PESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLES 189
+ ++ A RGH++C+ SL+ G D TPLY ACE + VK L++
Sbjct: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
Query: 190 GADVNQGKGQD-SPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPESPLAQL 248
AD N + + LH E+ +L+ GA ++KNA G P+ + L L
Sbjct: 180 NADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEAL 239
Query: 249 -FLEREGASL 257
FL + GA +
Sbjct: 240 RFLAKYGADI 249
Score = 67.8 bits (164), Expect = 9e-12
Identities = 45/159 (28%), Positives = 76/159 (47%), Gaps = 2/159 (1%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVN 96
W+ +HE+ ++ L+S G V A ++PL A G L ++ L K+GA +N
Sbjct: 191 WTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADIN 250
Query: 97 GVTADWHTPLFNACVSGSWDCVNLLLQHGASV-QPESDLASPIHEAARRGHVECVNSLIA 155
+D + L+ AC + + V LL GA + D P+H A+++G+ V L+
Sbjct: 251 TQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLP 310
Query: 156 YGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN 194
+ S + +PL+LA E ++ LL + DVN
Sbjct: 311 VTSRTRIRRSGV-SPLHLAAERNHDEVLEALLSARFDVN 348
Score = 45.8 bits (107), Expect = 4e-05
Identities = 47/165 (28%), Positives = 72/165 (43%), Gaps = 14/165 (8%)
Query: 39 PMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGV 98
P+H A+ G+ ++ L+ I + VSPLH A H ++ LL VN
Sbjct: 292 PLHIASKKGNYRIVQMLLPVTSRTRIRRSG-VSPLHLAAERNHDEVLEALLSARFDVNTP 350
Query: 99 TADWHTPLFN---------ACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVEC 149
A L+ A V+ + LLLQHGA P D+ SP+ A R G +
Sbjct: 351 LAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGAD--PNRDVISPLLVAIRHGCLRT 408
Query: 150 VNSLIAYGGNIDHKISHLGT--PLYLACENQQRACVKKLLESGAD 192
+ L+ +G NID I+ T P + + + +K L++ G D
Sbjct: 409 MQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCD 453
Score = 32.7 bits (73), Expect = 0.33
Identities = 29/133 (21%), Positives = 50/133 (37%), Gaps = 35/133 (26%)
Query: 135 ASPIHEAARRGHVECVNSLI----------------------------------AYGGNI 160
A P+ +A + G E + ++I AY G I
Sbjct: 58 ADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTI 117
Query: 161 DHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAVARTASEELACLLM 219
D + T +YLA C+ LL++GA+ + K +++PL+ + E +L+
Sbjct: 118 DQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILV 177
Query: 220 DFGADTQAKNAEG 232
ADT + G
Sbjct: 178 QHNADTNHRCNRG 190
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 93.2 bits (230), Expect = 2e-19
Identities = 73/230 (31%), Positives = 109/230 (47%), Gaps = 16/230 (6%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLS-CVKILLKHGAQVN 96
+P+H A +G + + LI G VN +PLH A H + C+++L+ +GA VN
Sbjct: 241 TPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVN 300
Query: 97 GVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLAS-PIHEAARRGHVECVNSLIA 155
+ D TPL + G + ++Q GA + E + P+H AAR GH +N+LI
Sbjct: 301 MKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLIT 360
Query: 156 YGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSP-------LHAVAR 208
G + + H PL+LA + C +KLL SG D+ D+P LHA A
Sbjct: 361 SGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDI------DTPDDFGRTCLHAAAA 414
Query: 209 TASEELACLLMDFGADTQAKNAEGKRPVELVPPESPLAQLF-LEREGASL 257
+ E LL++ GAD K+ G+ P+ LF L GAS+
Sbjct: 415 GGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASV 464
Score = 93.2 bits (230), Expect = 2e-19
Identities = 72/218 (33%), Positives = 106/218 (48%), Gaps = 10/218 (4%)
Query: 29 LMGDAVSDWSPMHEAAIHGHQLSLRNLISQGW---AVNIITADHVSPLHEACLGGHLSCV 85
L+ D + +P+H AA +GH LR LI AV+I + +PL + L GH CV
Sbjct: 610 LVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCV 669
Query: 86 KILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGAS-VQPESDLASPIHEAARR 144
LL GA V+ T L V+G +CV+ LLQHGA + +S +PIH +A
Sbjct: 670 YSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAAC 729
Query: 145 GHVECVNSLIAYGGNIDHK----ISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQD 200
GH+ + +L+ ++D +H T L+ AC N CV+ LLE
Sbjct: 730 GHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAF 789
Query: 201 SPLHAVARTASEELACLLMD-FGAD-TQAKNAEGKRPV 236
SPLH +E A +L+D GA A +++G+ P+
Sbjct: 790 SPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPL 827
Score = 92.0 bits (227), Expect = 5e-19
Identities = 66/206 (32%), Positives = 103/206 (50%), Gaps = 3/206 (1%)
Query: 36 DWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQV 95
D +H AA GH ++ L+S G V +PLH A G +S VK LL G +
Sbjct: 173 DRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDM 232
Query: 96 NGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA-SPIHEAARRGH-VECVNSL 153
N A +TPL AC +G VN L+ GA V +++ +P+H AA H C+ L
Sbjct: 233 NEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELL 292
Query: 154 IAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAVARTASE 212
+ G +++ K TPL++ + + + + +++SGA ++ + K ++PLH AR E
Sbjct: 293 VGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHE 352
Query: 213 ELACLLMDFGADTQAKNAEGKRPVEL 238
L L+ GADT + G P+ L
Sbjct: 353 LLINTLITSGADTAKRGIHGMFPLHL 378
Score = 91.3 bits (225), Expect = 8e-19
Identities = 67/220 (30%), Positives = 104/220 (47%), Gaps = 4/220 (1%)
Query: 22 IRLLSNPLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGH 81
+ LLSN + D + +H AA GH ++ L+S+G +N +H A GH
Sbjct: 127 VPLLSNVNVSDRAGR-TALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGH 185
Query: 82 LSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASV-QPESDLASPIHE 140
+ VK+L+ HGA+V +TPL A SG V LL G + +P + +P+H
Sbjct: 186 IEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245
Query: 141 AARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRA-CVKKLLESGADVN-QGKG 198
A G VN LI G ++ K TPL+ A + A C++ L+ +GADVN + K
Sbjct: 246 ACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 305
Query: 199 QDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVEL 238
+PLH A + ++ GA ++ G P+ +
Sbjct: 306 GKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHI 345
Score = 87.0 bits (214), Expect = 1e-17
Identities = 67/232 (28%), Positives = 113/232 (48%), Gaps = 21/232 (9%)
Query: 26 SNPLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADH-------------VSP 72
+NP + D ++ +H +A +GH+L L+ LI+ ++++ +SP
Sbjct: 496 ANPGIRDK-QGYNAVHYSAAYGHRLCLQ-LIASETPLDVLMETSGTDMLSDSDNRATISP 553
Query: 73 LHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPES 132
LH A GH +++L++ ++ + TPL A G +CV++L+ GAS+ +
Sbjct: 554 LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 613
Query: 133 DL--ASPIHEAARRGHVECVNSLIAYG---GNIDHKISHLGTPLYLACENQQRACVKKLL 187
+ +PIH AA GH EC+ LI +D + + TPL L+ N CV LL
Sbjct: 614 YILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLL 673
Query: 188 ESGADVN-QGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVEL 238
GA+V+ + K + LH A T EE L+ GA +++ G+ P+ L
Sbjct: 674 NKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHL 725
Score = 80.5 bits (197), Expect = 1e-15
Identities = 59/203 (29%), Positives = 96/203 (47%), Gaps = 2/203 (0%)
Query: 36 DWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQV 95
D + +A +G +R LI + VN + +PLH A G +++L+ GA+V
Sbjct: 8 DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
Query: 96 NGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQP-ESDLASPIHEAARRGHVECVNSLI 154
N + W TPL A S S + V +LL+H A V + + +P+H AA V+C +L+
Sbjct: 68 NAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALV 127
Query: 155 AYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQD-SPLHAVARTASEE 213
N++ T L+ A + VK LL GA++N +D +H A E
Sbjct: 128 PLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIE 187
Query: 214 LACLLMDFGADTQAKNAEGKRPV 236
+ LL+ GA+ K+ + P+
Sbjct: 188 VVKLLVSHGAEVTCKDKKSYTPL 210
Score = 79.7 bits (195), Expect = 2e-15
Identities = 57/203 (28%), Positives = 95/203 (46%), Gaps = 14/203 (6%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
SP+H AA HGH +L L+ +++ + +PL A GH+ CV +L+ GA +
Sbjct: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI-- 609
Query: 98 VTADW---HTPLFNACVSGSWDCVNLLL-----QHGASVQPESDLASPIHEAARRGHVEC 149
+ D+ TP+ A +G +C+ LL+ Q+ +Q + + +P+ + GH +C
Sbjct: 610 LVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQ-DGNGQTPLMLSVLNGHTDC 668
Query: 150 VNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGAD--VNQGKGQDSPLHAVA 207
V SL+ G N+D K T L+ CV LL+ GA + +G+ +P+H A
Sbjct: 669 VYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR-TPIHLSA 727
Query: 208 RTASEELACLLMDFGADTQAKNA 230
+ L+ A A A
Sbjct: 728 ACGHIGVLGALLQSAASMDANPA 750
Score = 78.2 bits (191), Expect = 7e-15
Identities = 65/236 (27%), Positives = 104/236 (44%), Gaps = 18/236 (7%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+H A+HG + +I G ++ + +PLH A GH + L+ GA
Sbjct: 308 TPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAK 367
Query: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASP-IHEAARRGHVECVNSLIAY 156
PL A +SG DC LL G + D +H AA G++EC+N L+
Sbjct: 368 RGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNT 427
Query: 157 GGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ-GKGQDSPLHAVARTASEELA 215
G + + K +PL+ A N C+ L+ SGA VN + +PLH A T+ +
Sbjct: 428 GADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLH-YAATSDTDGK 486
Query: 216 CL--LMDFGADTQAKNAEGKRPV------------ELVPPESPLAQLFLEREGASL 257
CL L+ A+ ++ +G V +L+ E+PL + +E G +
Sbjct: 487 CLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPL-DVLMETSGTDM 541
Score = 66.2 bits (160), Expect = 3e-11
Identities = 49/164 (29%), Positives = 80/164 (48%), Gaps = 7/164 (4%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGWA--VNIITADHVSPLHEACLGGHLSCVKILLKHGAQ 94
+SP+H A I+ ++ + LI A VN + +PLH A H+ C+++LL H AQ
Sbjct: 789 FSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQ 848
Query: 95 VNGVTADWHTPLFNACVSGSWDCVNLLLQHGAS--VQPESDLASPIHEAARRGH---VEC 149
VN V + TPL A +G + V +L+ ++ ++ + +H A +GH
Sbjct: 849 VNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALL 908
Query: 150 VNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADV 193
+ I I+ + L TPL++A N V++LL GA V
Sbjct: 909 ILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASV 952
Score = 38.1 bits (87), Expect = 0.008
Identities = 34/110 (30%), Positives = 48/110 (43%), Gaps = 6/110 (5%)
Query: 40 MHEAAIHGHQLSLRNLISQGWAVNIITADHVS---PLHEACLGGHLSCVKILLKHGAQVN 96
+H A GH+ S ++ + N+I A + + PLH A G V+ LL GA V
Sbjct: 894 LHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVL 953
Query: 97 GVTADWHTPLFNACVSGS--WDCVNLLLQHGASVQPESDLASPIHEAARR 144
V + +TP AC DC+ L+L V S L+S A R
Sbjct: 954 AVDENGYTPAL-ACAPNKDVADCLALILATMMPVSSSSPLSSLTFNAINR 1002
Score = 37.0 bits (84), Expect = 0.017
Identities = 26/100 (26%), Positives = 48/100 (48%), Gaps = 1/100 (1%)
Query: 140 EAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQ 199
+A G + V +LI +++ + + TPL+ A ++ L+ SGA VN +
Sbjct: 14 QAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSK 73
Query: 200 D-SPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVEL 238
+PLH + SEE +L+ AD A++ + P+ +
Sbjct: 74 WLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHI 113
>gi|16975496 cortactin binding protein 2 [Homo sapiens]
Length = 1663
Score = 92.8 bits (229), Expect = 3e-19
Identities = 66/189 (34%), Positives = 97/189 (51%), Gaps = 18/189 (9%)
Query: 35 SDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILL-KHGA 93
S WSP SL L+ G + A + L +A G+++ + +LL + G
Sbjct: 689 SGWSP-----------SLTPLLMSGGPAPL--AGRPTLLQQAAAQGNVTLLSMLLNEEGL 735
Query: 94 QVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQP-ESDLASPIHEAARRGHVECVNS 152
+N D H+ L++A +G DCV LLL A V + + +P+ AA +GH ECV
Sbjct: 736 DINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVEL 795
Query: 153 LIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQD--SPLHAVARTA 210
LI+Y NI+H TPLYLAC+N + C+K LLE+G + K D +P+HA T
Sbjct: 796 LISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTN-RSVKTTDGWTPVHAAVDTG 854
Query: 211 SEELACLLM 219
+ + LLM
Sbjct: 855 NVDSLKLLM 863
Score = 53.1 bits (126), Expect = 2e-07
Identities = 36/136 (26%), Positives = 64/136 (47%), Gaps = 3/136 (2%)
Query: 104 TPLFNACVSGSWDCVNLLL-QHGASVQPE-SDLASPIHEAARRGHVECVNSLIAYGGNID 161
T L A G+ +++LL + G + D S ++ AA+ GH +CV L++ ++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 162 HKISHLGTPLYLACENQQRACVKKLLESGADVNQGK-GQDSPLHAVARTASEELACLLMD 220
+ TPL A CV+ L+ A++N G +PL+ + ++E LL++
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
Query: 221 FGADTQAKNAEGKRPV 236
G + K +G PV
Sbjct: 832 AGTNRSVKTTDGWTPV 847
Score = 52.4 bits (124), Expect = 4e-07
Identities = 41/159 (25%), Positives = 68/159 (42%), Gaps = 5/159 (3%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVN 96
++P+ AA GH + LIS +N +PL+ AC G+ C+K+LL+ G +
Sbjct: 778 FTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRS 837
Query: 97 GVTADWHTPLFNACVSGSWDCVNLLL-----QHGASVQPESDLASPIHEAARRGHVECVN 151
T D TP+ A +G+ D + LL+ HG S E +S E ++
Sbjct: 838 VKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEESPEGIS 897
Query: 152 SLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESG 190
+ I+H T ++A + C++ L G
Sbjct: 898 KPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 92.4 bits (228), Expect = 4e-19
Identities = 65/209 (31%), Positives = 96/209 (45%), Gaps = 2/209 (0%)
Query: 37 WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVN 96
W+P+H AA + + R L+S+ N+ A+ +PLH A GH+S VK+L GA+++
Sbjct: 462 WTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELD 521
Query: 97 GVTADWHTPLFNACVSGSWDCVNLLLQHGASVQP-ESDLASPIHEAARRGHVECVNSLIA 155
+ TPL A G + LL+ GA + P+H AA RG L+
Sbjct: 522 AQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLR 581
Query: 156 YGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ-GKGQDSPLHAVARTASEEL 214
YG +++ TPL+LA + L ES A++ G +PLH AR E +
Sbjct: 582 YGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAV 641
Query: 215 ACLLMDFGADTQAKNAEGKRPVELVPPES 243
L+ GAD A G P+ L S
Sbjct: 642 VSALLQCGADPNAAEQSGWTPLHLAVQRS 670
Score = 91.3 bits (225), Expect = 8e-19
Identities = 68/223 (30%), Positives = 110/223 (49%), Gaps = 3/223 (1%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+H AA GH ++ L SQG ++ + +PLH A G + ++ LLK GA +
Sbjct: 496 TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDA 555
Query: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQ-PESDLASPIHEAARRGHVECVNSLIAY 156
+ + PL A G + +LL++GAS++ P +P+H AA +GH+E ++ L
Sbjct: 556 LDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAES 615
Query: 157 GGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQD-SPLHAVARTASEELA 215
N+ + TPL+LA + + A V LL+ GAD N + +PLH + ++
Sbjct: 616 HANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSV 675
Query: 216 CLLMDFGADTQAKNAEGKRPVELVPPESPLAQL-FLEREGASL 257
L++ A+ A+N G P L + A L L GA L
Sbjct: 676 INLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQL 718
Score = 77.8 bits (190), Expect = 9e-15
Identities = 69/252 (27%), Positives = 100/252 (39%), Gaps = 37/252 (14%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+H G +R L++ V+ TA +PL A +LL HGA N
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
Query: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQP--------------------------- 130
V D PL A +G LLL HGA V
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483
Query: 131 -------ESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACV 183
E++ +P+H AA GHV V L + G +D + +L TPL+LA E + +
Sbjct: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAI 543
Query: 184 KKLLESGA--DVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVPP 241
+ LL+SGA D G PLH A + +L+ +GA + +G P+ L
Sbjct: 544 QHLLKSGAVPDALDQSGY-GPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAY 602
Query: 242 ESPLAQLFLERE 253
+ L + L E
Sbjct: 603 KGHLEIIHLLAE 614
Score = 74.7 bits (182), Expect = 8e-14
Identities = 55/176 (31%), Positives = 82/176 (46%), Gaps = 2/176 (1%)
Query: 65 ITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQH 124
I + V+PLH G + V++LL H V+ TA +TPL A D LLL H
Sbjct: 358 IYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417
Query: 125 GASV-QPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACV 183
GA + + D +P+H AA+ G L+ +G +D + TPL+LA +N
Sbjct: 418 GADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVA 477
Query: 184 KKLLESGADVNQGKGQ-DSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVEL 238
+ L+ AD N + + +PLH A L LL GA+ A+ + P+ L
Sbjct: 478 RLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHL 533
Score = 71.6 bits (174), Expect = 6e-13
Identities = 61/216 (28%), Positives = 98/216 (45%), Gaps = 6/216 (2%)
Query: 24 LLSNPLMGDAV--SDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGH 81
LL + + DA+ S + P+H AA G L + L+ G ++ + T +PLH A GH
Sbjct: 546 LLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGH 605
Query: 82 LSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQ-PESDLASPIHE 140
L + +L + A + + A TPL A G V+ LLQ GA E +P+H
Sbjct: 606 LEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHL 665
Query: 141 AARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQD 200
A +R V +L+ + N+ + TP +LA A +K L+E+GA ++ G
Sbjct: 666 AVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVS 725
Query: 201 -SPLHAVARTASEELACLLMDFGADTQAKNAEGKRP 235
+PL R+ + + L G + G +P
Sbjct: 726 CTPLQLALRSRKQGIMSFLE--GKEPSVATLGGSKP 759
>gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2
[Homo sapiens]
Length = 474
Score = 92.4 bits (228), Expect = 4e-19
Identities = 73/228 (32%), Positives = 103/228 (45%), Gaps = 19/228 (8%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+H AA GH LR L+ + + + LHEAC GH +CV +LL GA N
Sbjct: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTA-LHEACAAGHTACVHVLLVAGADPNI 221
Query: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASV--QPESDLASPIHEAARRGHVECVNSLIA 155
D PL G+ +C LLL+ GA V + E + +P+H AAR GHVE + L+
Sbjct: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
Query: 156 YGGNIDHKISHLGTPLYLAC----------ENQQRACVK---KLLESGADVNQG-KGQDS 201
G D + + TPL AC E C++ LL +GAD + + +
Sbjct: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
Query: 202 PLHAVARTASEELACLLMDFGADTQAKNAEGKRPVE--LVPPESPLAQ 247
PLH R + LL+ G + G P+ L P + LAQ
Sbjct: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 389
Score = 56.2 bits (134), Expect = 3e-08
Identities = 58/207 (28%), Positives = 78/207 (37%), Gaps = 59/207 (28%)
Query: 75 EACLGGHLSCVKILLKHGAQVNGVTAD----------WHTPLFNACVSGSWDCVNLLLQH 124
+A L G + CV +L + G+ D W FN W
Sbjct: 105 QAVLAGDVGCVSRILADSS--TGLAPDSVFDTSDPERWRDFRFNIRALRLW--------- 153
Query: 125 GASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVK 184
S+ E +L +P+H AA RGH E + L+ D T L+ AC ACV
Sbjct: 154 --SLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGG-RTALHEACAAGHTACVH 210
Query: 185 KLLESGADVN-------------QGKG----------------------QDSPLHAVART 209
LL +GAD N +G G +++PLH AR
Sbjct: 211 VLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARL 270
Query: 210 ASEELACLLMDFGADTQAKNAEGKRPV 236
ELA LL+ GA A+NAEG P+
Sbjct: 271 GHVELADLLLRRGACPDARNAEGWTPL 297
>gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1
[Homo sapiens]
Length = 512
Score = 92.4 bits (228), Expect = 4e-19
Identities = 73/228 (32%), Positives = 103/228 (45%), Gaps = 19/228 (8%)
Query: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
+P+H AA GH LR L+ + + + LHEAC GH +CV +LL GA N
Sbjct: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTA-LHEACAAGHTACVHVLLVAGADPNI 221
Query: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASV--QPESDLASPIHEAARRGHVECVNSLIA 155
D PL G+ +C LLL+ GA V + E + +P+H AAR GHVE + L+
Sbjct: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
Query: 156 YGGNIDHKISHLGTPLYLAC----------ENQQRACVK---KLLESGADVNQG-KGQDS 201
G D + + TPL AC E C++ LL +GAD + + +
Sbjct: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
Query: 202 PLHAVARTASEELACLLMDFGADTQAKNAEGKRPVE--LVPPESPLAQ 247
PLH R + LL+ G + G P+ L P + LAQ
Sbjct: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 389
Score = 56.2 bits (134), Expect = 3e-08
Identities = 58/207 (28%), Positives = 78/207 (37%), Gaps = 59/207 (28%)
Query: 75 EACLGGHLSCVKILLKHGAQVNGVTAD----------WHTPLFNACVSGSWDCVNLLLQH 124
+A L G + CV +L + G+ D W FN W
Sbjct: 105 QAVLAGDVGCVSRILADSS--TGLAPDSVFDTSDPERWRDFRFNIRALRLW--------- 153
Query: 125 GASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVK 184
S+ E +L +P+H AA RGH E + L+ D T L+ AC ACV
Sbjct: 154 --SLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGG-RTALHEACAAGHTACVH 210
Query: 185 KLLESGADVN-------------QGKG----------------------QDSPLHAVART 209
LL +GAD N +G G +++PLH AR
Sbjct: 211 VLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARL 270
Query: 210 ASEELACLLMDFGADTQAKNAEGKRPV 236
ELA LL+ GA A+NAEG P+
Sbjct: 271 GHVELADLLLRRGACPDARNAEGWTPL 297
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,755,402
Number of Sequences: 37866
Number of extensions: 552814
Number of successful extensions: 5093
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 318
Number of HSP's successfully gapped in prelim test: 38
Number of HSP's that attempted gapping in prelim test: 1424
Number of HSP's gapped (non-prelim): 1562
length of query: 262
length of database: 18,247,518
effective HSP length: 100
effective length of query: 162
effective length of database: 14,460,918
effective search space: 2342668716
effective search space used: 2342668716
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.