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Search of human proteins with 60218887
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|60218887 ankyrin repeat and SOCS box-containing protein 11
isoform b [Homo sapiens]
(302 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|60218887 ankyrin repeat and SOCS box-containing protein 11 is... 619 e-177
gi|18254474 ankyrin repeat and SOCS box-containing protein 11 is... 535 e-152
gi|18254476 ankyrin repeat and SOCS box-containing protein 5 [Ho... 298 4e-81
gi|72534772 ankyrin repeat and SOCS box-containing 9 isoform 1 [... 292 3e-79
gi|13443014 ankyrin repeat and SOCS box-containing 9 isoform 2 [... 248 6e-66
gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [H... 196 2e-50
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 102 4e-22
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 102 4e-22
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 102 4e-22
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 102 4e-22
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 102 4e-22
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 99 5e-21
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 99 5e-21
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 99 5e-21
gi|94721248 ankyrin repeat and SOCS box-containing protein 1 [Ho... 99 6e-21
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 97 1e-20
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 97 1e-20
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 96 3e-20
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 96 4e-20
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 96 4e-20
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 96 4e-20
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 96 4e-20
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 95 9e-20
gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2... 94 2e-19
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 92 7e-19
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 91 1e-18
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 91 2e-18
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 90 3e-18
gi|38176283 ankyrin repeat and SOCS box-containing protein 7 iso... 89 4e-18
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 89 5e-18
>gi|60218887 ankyrin repeat and SOCS box-containing protein 11
isoform b [Homo sapiens]
Length = 302
Score = 619 bits (1595), Expect = e-177
Identities = 302/302 (100%), Positives = 302/302 (100%)
Query: 1 MLQLTGENEKNCEVSERIRRSGPWKEISFGDYICHTFQGDCWADRSPLHEAAAQGRLLAL 60
MLQLTGENEKNCEVSERIRRSGPWKEISFGDYICHTFQGDCWADRSPLHEAAAQGRLLAL
Sbjct: 1 MLQLTGENEKNCEVSERIRRSGPWKEISFGDYICHTFQGDCWADRSPLHEAAAQGRLLAL 60
Query: 61 KTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCS 120
KTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCS
Sbjct: 61 KTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCS 120
Query: 121 GSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLY 180
GSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLY
Sbjct: 121 GSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLY 180
Query: 181 VACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQG 240
VACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQG
Sbjct: 181 VACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQG 240
Query: 241 KSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLL 300
KSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLL
Sbjct: 241 KSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLL 300
Query: 301 YQ 302
YQ
Sbjct: 301 YQ 302
>gi|18254474 ankyrin repeat and SOCS box-containing protein 11
isoform a [Homo sapiens]
Length = 323
Score = 535 bits (1379), Expect = e-152
Identities = 263/263 (100%), Positives = 263/263 (100%)
Query: 40 DCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLEN 99
DCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLEN
Sbjct: 61 DCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLEN 120
Query: 100 GAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECME 159
GAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECME
Sbjct: 121 GAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECME 180
Query: 160 ILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSN 219
ILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSN
Sbjct: 181 ILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSN 240
Query: 220 VEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLG 279
VEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLG
Sbjct: 241 VEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLG 300
Query: 280 RACHQAIHKLHLPEPLERFLLYQ 302
RACHQAIHKLHLPEPLERFLLYQ
Sbjct: 301 RACHQAIHKLHLPEPLERFLLYQ 323
>gi|18254476 ankyrin repeat and SOCS box-containing protein 5 [Homo
sapiens]
Length = 329
Score = 298 bits (763), Expect = 4e-81
Identities = 144/262 (54%), Positives = 192/262 (73%), Gaps = 1/262 (0%)
Query: 42 WADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGA 101
WADRSPLHEAA+QGRLLAL+TL++QG NVN VT++ V+ LHEACLG HVACA+ LLE GA
Sbjct: 68 WADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGA 127
Query: 102 HVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEIL 161
+VN +T+ G TPLFNAC GS +C +LLE+GAKAQLE L SP HEA +GH EC++IL
Sbjct: 128 NVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAASKGHHECLDIL 187
Query: 162 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVE 221
++ +++D E+P LGTPLYVAC Q+ C+ KLL GA V G++ DTPLHAAA+QS+ E
Sbjct: 188 ISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAAAQQSSTE 247
Query: 222 VIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREG-PPALSQLCRLCVRKCLGR 280
+++LL ++GA++ +N + +D+A S VE+ LL E P +L QLCRLC+R +G+
Sbjct: 248 IVNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQHEATPSSLYQLCRLCIRSYIGK 307
Query: 281 ACHQAIHKLHLPEPLERFLLYQ 302
I +L LP L+ FL Y+
Sbjct: 308 PRLHLIPQLQLPTLLKNFLQYR 329
>gi|72534772 ankyrin repeat and SOCS box-containing 9 isoform 1
[Homo sapiens]
Length = 294
Score = 292 bits (747), Expect = 3e-79
Identities = 147/269 (54%), Positives = 190/269 (70%)
Query: 33 ICHTFQGDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVAC 92
+ + GD +D SP+HEAA G L+L+ LI+QG VN++T + VS LHEACLGGH++C
Sbjct: 25 LSNPLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSC 84
Query: 93 AKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKR 152
K LL++GA VNGVT TPLFNAC SGS CVN+LL+ GA Q E LASPIHEA +R
Sbjct: 85 VKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARR 144
Query: 153 GHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLH 212
GH EC+ L+A NIDH++ LGTPLY+AC Q+ CVKKLLE GA V+ G+ D+PLH
Sbjct: 145 GHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLH 204
Query: 213 AAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCRL 272
A AR ++ E+ LL D+GA+ + +NA+GK ++L P+S + Q L REGPP+L QLCRL
Sbjct: 205 AVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPESPLAQLFLEREGPPSLMQLCRL 264
Query: 273 CVRKCLGRACHQAIHKLHLPEPLERFLLY 301
+RKC G H I KL LPE L++FLL+
Sbjct: 265 RIRKCFGIQQHHKITKLVLPEDLKQFLLH 293
>gi|13443014 ankyrin repeat and SOCS box-containing 9 isoform 2
[Homo sapiens]
Length = 262
Score = 248 bits (632), Expect = 6e-66
Identities = 124/230 (53%), Positives = 162/230 (70%)
Query: 33 ICHTFQGDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVAC 92
+ + GD +D SP+HEAA G L+L+ LI+QG VN++T + VS LHEACLGGH++C
Sbjct: 25 LSNPLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSC 84
Query: 93 AKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKR 152
K LL++GA VNGVT TPLFNAC SGS CVN+LL+ GA Q E LASPIHEA +R
Sbjct: 85 VKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARR 144
Query: 153 GHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLH 212
GH EC+ L+A NIDH++ LGTPLY+AC Q+ CVKKLLE GA V+ G+ D+PLH
Sbjct: 145 GHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLH 204
Query: 213 AAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREG 262
A AR ++ E+ LL D+GA+ + +NA+GK ++L P+S + Q L REG
Sbjct: 205 AVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPESPLAQLFLEREG 254
>gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [Homo
sapiens]
Length = 278
Score = 196 bits (499), Expect = 2e-50
Identities = 108/268 (40%), Positives = 156/268 (58%), Gaps = 3/268 (1%)
Query: 37 FQGDC--WADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAK 94
F GD W +R+P+HEAA +G L L+ LI G VN VT++ ++ LH A L G C +
Sbjct: 10 FLGDVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQ 69
Query: 95 ALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGH 154
LL GA V+ + G+TPL +AC SGS CV +LL +GAK ++ ASP+HEA G
Sbjct: 70 LLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGS 129
Query: 155 RECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAA 214
EC+ +L+ N++ GTPL+VAC + +DCVK LL GA+V+ + +T LH A
Sbjct: 130 SECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHA 189
Query: 215 ARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPP-ALSQLCRLC 273
A+ NV++I +L ++G N+ R+ +GK D S+ + E P LSQLCR+
Sbjct: 190 AKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPLTLSQLCRVN 249
Query: 274 VRKCLGRACHQAIHKLHLPEPLERFLLY 301
+RK G + I KL++P L +L Y
Sbjct: 250 LRKATGVRGLEKIAKLNIPPRLIDYLSY 277
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 102 bits (254), Expect = 4e-22
Identities = 79/249 (31%), Positives = 107/249 (42%), Gaps = 35/249 (14%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A+ G L +K L+ +G + N+ + + LH A GH AK LL+N A VN
Sbjct: 439 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 498
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQL-------EVHLA--------------- 143
TPL A G V +LLE A L +H+A
Sbjct: 499 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 558
Query: 144 ------------SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCV 191
+P+H A K G E+LL + + + TPL+VA + +D V
Sbjct: 559 EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIV 618
Query: 192 KKLLELGASVDHGQWLD-TPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPK 250
K LL G S W TPLH AA+Q+ VEV L YG + + QG + L LAA +
Sbjct: 619 KLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE 678
Query: 251 SSVEQALLL 259
E LL
Sbjct: 679 GHAEMVALL 687
Score = 97.4 bits (241), Expect = 1e-20
Identities = 61/216 (28%), Positives = 109/216 (50%), Gaps = 2/216 (0%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A+ +G ++ ++ L+ +G + T + ++ LH A GHV ++ LL++GA +
Sbjct: 274 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 333
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEILLAN 164
T +G +P+ A CV +LL++ A+ + + +P+H A GH ++LL
Sbjct: 334 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 393
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 223
+ TPL++AC V ++ LL+ GAS+D TPLH A+ ++ ++
Sbjct: 394 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 453
Query: 224 HLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 259
L GA+ N + ++ L +AA E A L
Sbjct: 454 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489
Score = 95.9 bits (237), Expect = 4e-20
Identities = 72/219 (32%), Positives = 106/219 (48%), Gaps = 5/219 (2%)
Query: 48 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVT 107
LH AA G+ ++ L+ G NVN + + L+ A H+ K LLENGA+ N T
Sbjct: 115 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 174
Query: 108 VHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVN 167
G TPL A G V L+ +G K ++ + +H A + +LL N+ N
Sbjct: 175 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRL---PALHIAARNDDTRTAAVLLQNDPN 231
Query: 168 IDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLL 226
D TPL++A Y+ ++ + LL GASV+ Q TPLH A+R+ NV ++ LL
Sbjct: 232 PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 291
Query: 227 TDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREGPP 264
D GA ++ + + L AA V +LL G P
Sbjct: 292 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 330
Score = 94.4 bits (233), Expect = 1e-19
Identities = 79/250 (31%), Positives = 121/250 (48%), Gaps = 10/250 (4%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH AA L + L+ +G +VN N ++ LH A G+V + LL+ GA +
Sbjct: 241 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 300
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 164
T TPL A +G +LL+ GA Q + + SPIH A + H +C+ +LL
Sbjct: 301 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 360
Query: 165 NVNIDHEVPQLGTPLYVA--CTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 220
+ ID TPL+VA C + RV K LL+ GA + + L+ TPLH A ++++V
Sbjct: 361 DAEIDDITLDHLTPLHVAAHCGHHRV--AKVLLDKGAK-PNSRALNGFTPLHIACKKNHV 417
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAA--PKSSVEQALLLREGPPALSQLCRLCVRKCL 278
V+ LL GA++ G + L +A+ + + LL R P +S +
Sbjct: 418 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 477
Query: 279 GRACHQAIHK 288
RA H + K
Sbjct: 478 ARAGHTEVAK 487
Score = 90.5 bits (223), Expect = 2e-18
Identities = 69/223 (30%), Positives = 107/223 (47%), Gaps = 4/223 (1%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A + + ++ L+ G +++ VT + ++ LH A GH+ K LL+ GA N
Sbjct: 406 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 465
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 164
V TPL A +G LL+ AK + +P+H A + GH +++LL N
Sbjct: 466 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 525
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGAS-VDHGQWLDTPLHAAARQSNVEVI 223
N N + TPL++A V+ V LLE AS + TPLH AA+ V V
Sbjct: 526 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 585
Query: 224 HLLTDYGANLKRRNAQGKSALDLAAPKSSVE--QALLLREGPP 264
LL + A+ G + L +A ++++ + LL R G P
Sbjct: 586 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 628
Score = 89.0 bits (219), Expect = 5e-18
Identities = 64/204 (31%), Positives = 99/204 (48%), Gaps = 2/204 (0%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A L +K L+ +G + + N + LH A V A++LL+ G N
Sbjct: 604 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 663
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 164
+V G TPL A G A V +LL A L +P+H + GH ++L+ +
Sbjct: 664 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 723
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 223
V +D TPL+VA Y + VK LL+ A V+ L +PLH AA+Q + +++
Sbjct: 724 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 783
Query: 224 HLLTDYGANLKRRNAQGKSALDLA 247
LL GA+ ++ G + L +A
Sbjct: 784 TLLLKNGASPNEVSSDGTTPLAIA 807
Score = 82.8 bits (203), Expect = 3e-16
Identities = 61/220 (27%), Positives = 100/220 (45%), Gaps = 3/220 (1%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH AA G++ + L+ + + N N ++ LH A ++ K LL G +
Sbjct: 571 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 630
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE-VHLASPIHEAVKRGHRECMEILLAN 164
+G TPL A LL++G A E V +P+H A + GH E + +LL+
Sbjct: 631 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 690
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 223
N + TPL++ V L++ G VD + TPLH A+ N++++
Sbjct: 691 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 750
Query: 224 HLLTDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREG 262
L + A++ + G S L AA + + LLL+ G
Sbjct: 751 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 790
Score = 75.1 bits (183), Expect = 7e-14
Identities = 78/283 (27%), Positives = 113/283 (39%), Gaps = 67/283 (23%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVT----------------------IN------- 76
+PL+ AA + L +K L+ G N N+ T IN
Sbjct: 146 TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 205
Query: 77 RVSSLHEACLGGHVACAKALLEN---------------------------------GAHV 103
R+ +LH A A LL+N GA V
Sbjct: 206 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 265
Query: 104 NGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILL 162
N +G TPL A G+ V +LL+ GA+ + + +P+H A + GH EILL
Sbjct: 266 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 325
Query: 163 ANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 220
+ I + +P+++A +DCV+ LL+ A +D LD TPLH AA +
Sbjct: 326 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID-DITLDHLTPLHVAAHCGHH 384
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREG 262
V +L D GA R G + L +A K+ V LLL+ G
Sbjct: 385 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 427
Score = 63.2 bits (152), Expect = 3e-10
Identities = 57/210 (27%), Positives = 84/210 (40%), Gaps = 4/210 (1%)
Query: 51 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHG 110
AA G L + GV++N N ++ LH A GHV LL + T G
Sbjct: 52 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 111
Query: 111 ATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLANNVNID 169
T L A +G V L+ +GA + +P++ A + H E ++ LL N N +
Sbjct: 112 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 171
Query: 170 HEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDY 229
TPL VA + V L+ G G+ LH AAR + +L
Sbjct: 172 VATEDGFTPLAVALQQGHENVVAHLINYGTK---GKVRLPALHIAARNDDTRTAAVLLQN 228
Query: 230 GANLKRRNAQGKSALDLAAPKSSVEQALLL 259
N + G + L +AA ++ A LL
Sbjct: 229 DPNPDVLSKTGFTPLHIAAHYENLNVAQLL 258
Score = 50.4 bits (119), Expect = 2e-06
Identities = 36/117 (30%), Positives = 56/117 (47%), Gaps = 1/117 (0%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A +G + LI GV V+ T + LH A G++ K LL++ A VN
Sbjct: 703 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 762
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEIL 161
T G +PL A G V +LL+ GA ++ +P+ A + G+ ++L
Sbjct: 763 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
Score = 35.4 bits (80), Expect = 0.062
Identities = 19/54 (35%), Positives = 31/54 (57%)
Query: 208 DTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 261
+T LH AA EV+ L +YGAN+ ++ +G + L +AA ++ +E L E
Sbjct: 112 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 165
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 102 bits (254), Expect = 4e-22
Identities = 79/249 (31%), Positives = 107/249 (42%), Gaps = 35/249 (14%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A+ G L +K L+ +G + N+ + + LH A GH AK LL+N A VN
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQL-------EVHLA--------------- 143
TPL A G V +LLE A L +H+A
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525
Query: 144 ------------SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCV 191
+P+H A K G E+LL + + + TPL+VA + +D V
Sbjct: 526 EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIV 585
Query: 192 KKLLELGASVDHGQWLD-TPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPK 250
K LL G S W TPLH AA+Q+ VEV L YG + + QG + L LAA +
Sbjct: 586 KLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE 645
Query: 251 SSVEQALLL 259
E LL
Sbjct: 646 GHAEMVALL 654
Score = 97.4 bits (241), Expect = 1e-20
Identities = 61/216 (28%), Positives = 109/216 (50%), Gaps = 2/216 (0%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A+ +G ++ ++ L+ +G + T + ++ LH A GHV ++ LL++GA +
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEILLAN 164
T +G +P+ A CV +LL++ A+ + + +P+H A GH ++LL
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 223
+ TPL++AC V ++ LL+ GAS+D TPLH A+ ++ ++
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 224 HLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 259
L GA+ N + ++ L +AA E A L
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Score = 95.9 bits (237), Expect = 4e-20
Identities = 72/219 (32%), Positives = 106/219 (48%), Gaps = 5/219 (2%)
Query: 48 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVT 107
LH AA G+ ++ L+ G NVN + + L+ A H+ K LLENGA+ N T
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 108 VHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVN 167
G TPL A G V L+ +G K ++ + +H A + +LL N+ N
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRL---PALHIAARNDDTRTAAVLLQNDPN 198
Query: 168 IDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLL 226
D TPL++A Y+ ++ + LL GASV+ Q TPLH A+R+ NV ++ LL
Sbjct: 199 PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
Query: 227 TDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREGPP 264
D GA ++ + + L AA V +LL G P
Sbjct: 259 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297
Score = 94.4 bits (233), Expect = 1e-19
Identities = 79/250 (31%), Positives = 121/250 (48%), Gaps = 10/250 (4%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH AA L + L+ +G +VN N ++ LH A G+V + LL+ GA +
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 164
T TPL A +G +LL+ GA Q + + SPIH A + H +C+ +LL
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 327
Query: 165 NVNIDHEVPQLGTPLYVA--CTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 220
+ ID TPL+VA C + RV K LL+ GA + + L+ TPLH A ++++V
Sbjct: 328 DAEIDDITLDHLTPLHVAAHCGHHRV--AKVLLDKGAK-PNSRALNGFTPLHIACKKNHV 384
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAA--PKSSVEQALLLREGPPALSQLCRLCVRKCL 278
V+ LL GA++ G + L +A+ + + LL R P +S +
Sbjct: 385 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
Query: 279 GRACHQAIHK 288
RA H + K
Sbjct: 445 ARAGHTEVAK 454
Score = 90.5 bits (223), Expect = 2e-18
Identities = 69/223 (30%), Positives = 107/223 (47%), Gaps = 4/223 (1%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A + + ++ L+ G +++ VT + ++ LH A GH+ K LL+ GA N
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 164
V TPL A +G LL+ AK + +P+H A + GH +++LL N
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGAS-VDHGQWLDTPLHAAARQSNVEVI 223
N N + TPL++A V+ V LLE AS + TPLH AA+ V V
Sbjct: 493 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 552
Query: 224 HLLTDYGANLKRRNAQGKSALDLAAPKSSVE--QALLLREGPP 264
LL + A+ G + L +A ++++ + LL R G P
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Score = 89.0 bits (219), Expect = 5e-18
Identities = 64/204 (31%), Positives = 99/204 (48%), Gaps = 2/204 (0%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A L +K L+ +G + + N + LH A V A++LL+ G N
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 164
+V G TPL A G A V +LL A L +P+H + GH ++L+ +
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 223
V +D TPL+VA Y + VK LL+ A V+ L +PLH AA+Q + +++
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
Query: 224 HLLTDYGANLKRRNAQGKSALDLA 247
LL GA+ ++ G + L +A
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIA 774
Score = 82.8 bits (203), Expect = 3e-16
Identities = 61/220 (27%), Positives = 100/220 (45%), Gaps = 3/220 (1%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH AA G++ + L+ + + N N ++ LH A ++ K LL G +
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE-VHLASPIHEAVKRGHRECMEILLAN 164
+G TPL A LL++G A E V +P+H A + GH E + +LL+
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 223
N + TPL++ V L++ G VD + TPLH A+ N++++
Sbjct: 658 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 717
Query: 224 HLLTDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREG 262
L + A++ + G S L AA + + LLL+ G
Sbjct: 718 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 757
Score = 75.1 bits (183), Expect = 7e-14
Identities = 78/283 (27%), Positives = 113/283 (39%), Gaps = 67/283 (23%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVT----------------------IN------- 76
+PL+ AA + L +K L+ G N N+ T IN
Sbjct: 113 TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 172
Query: 77 RVSSLHEACLGGHVACAKALLEN---------------------------------GAHV 103
R+ +LH A A LL+N GA V
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232
Query: 104 NGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILL 162
N +G TPL A G+ V +LL+ GA+ + + +P+H A + GH EILL
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
Query: 163 ANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 220
+ I + +P+++A +DCV+ LL+ A +D LD TPLH AA +
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID-DITLDHLTPLHVAAHCGHH 351
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREG 262
V +L D GA R G + L +A K+ V LLL+ G
Sbjct: 352 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 394
Score = 63.2 bits (152), Expect = 3e-10
Identities = 57/210 (27%), Positives = 84/210 (40%), Gaps = 4/210 (1%)
Query: 51 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHG 110
AA G L + GV++N N ++ LH A GHV LL + T G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 111 ATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLANNVNID 169
T L A +G V L+ +GA + +P++ A + H E ++ LL N N +
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 170 HEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDY 229
TPL VA + V L+ G G+ LH AAR + +L
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHLINYGTK---GKVRLPALHIAARNDDTRTAAVLLQN 195
Query: 230 GANLKRRNAQGKSALDLAAPKSSVEQALLL 259
N + G + L +AA ++ A LL
Sbjct: 196 DPNPDVLSKTGFTPLHIAAHYENLNVAQLL 225
Score = 50.4 bits (119), Expect = 2e-06
Identities = 36/117 (30%), Positives = 56/117 (47%), Gaps = 1/117 (0%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A +G + LI GV V+ T + LH A G++ K LL++ A VN
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEIL 161
T G +PL A G V +LL+ GA ++ +P+ A + G+ ++L
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 35.4 bits (80), Expect = 0.062
Identities = 19/54 (35%), Positives = 31/54 (57%)
Query: 208 DTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 261
+T LH AA EV+ L +YGAN+ ++ +G + L +AA ++ +E L E
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 102 bits (254), Expect = 4e-22
Identities = 79/249 (31%), Positives = 107/249 (42%), Gaps = 35/249 (14%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A+ G L +K L+ +G + N+ + + LH A GH AK LL+N A VN
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQL-------EVHLA--------------- 143
TPL A G V +LLE A L +H+A
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525
Query: 144 ------------SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCV 191
+P+H A K G E+LL + + + TPL+VA + +D V
Sbjct: 526 EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIV 585
Query: 192 KKLLELGASVDHGQWLD-TPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPK 250
K LL G S W TPLH AA+Q+ VEV L YG + + QG + L LAA +
Sbjct: 586 KLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE 645
Query: 251 SSVEQALLL 259
E LL
Sbjct: 646 GHAEMVALL 654
Score = 97.4 bits (241), Expect = 1e-20
Identities = 61/216 (28%), Positives = 109/216 (50%), Gaps = 2/216 (0%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A+ +G ++ ++ L+ +G + T + ++ LH A GHV ++ LL++GA +
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEILLAN 164
T +G +P+ A CV +LL++ A+ + + +P+H A GH ++LL
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 223
+ TPL++AC V ++ LL+ GAS+D TPLH A+ ++ ++
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 224 HLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 259
L GA+ N + ++ L +AA E A L
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Score = 95.9 bits (237), Expect = 4e-20
Identities = 72/219 (32%), Positives = 106/219 (48%), Gaps = 5/219 (2%)
Query: 48 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVT 107
LH AA G+ ++ L+ G NVN + + L+ A H+ K LLENGA+ N T
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 108 VHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVN 167
G TPL A G V L+ +G K ++ + +H A + +LL N+ N
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRL---PALHIAARNDDTRTAAVLLQNDPN 198
Query: 168 IDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLL 226
D TPL++A Y+ ++ + LL GASV+ Q TPLH A+R+ NV ++ LL
Sbjct: 199 PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
Query: 227 TDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREGPP 264
D GA ++ + + L AA V +LL G P
Sbjct: 259 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297
Score = 94.4 bits (233), Expect = 1e-19
Identities = 79/250 (31%), Positives = 121/250 (48%), Gaps = 10/250 (4%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH AA L + L+ +G +VN N ++ LH A G+V + LL+ GA +
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 164
T TPL A +G +LL+ GA Q + + SPIH A + H +C+ +LL
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 327
Query: 165 NVNIDHEVPQLGTPLYVA--CTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 220
+ ID TPL+VA C + RV K LL+ GA + + L+ TPLH A ++++V
Sbjct: 328 DAEIDDITLDHLTPLHVAAHCGHHRV--AKVLLDKGAK-PNSRALNGFTPLHIACKKNHV 384
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAA--PKSSVEQALLLREGPPALSQLCRLCVRKCL 278
V+ LL GA++ G + L +A+ + + LL R P +S +
Sbjct: 385 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
Query: 279 GRACHQAIHK 288
RA H + K
Sbjct: 445 ARAGHTEVAK 454
Score = 90.5 bits (223), Expect = 2e-18
Identities = 69/223 (30%), Positives = 107/223 (47%), Gaps = 4/223 (1%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A + + ++ L+ G +++ VT + ++ LH A GH+ K LL+ GA N
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 164
V TPL A +G LL+ AK + +P+H A + GH +++LL N
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGAS-VDHGQWLDTPLHAAARQSNVEVI 223
N N + TPL++A V+ V LLE AS + TPLH AA+ V V
Sbjct: 493 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 552
Query: 224 HLLTDYGANLKRRNAQGKSALDLAAPKSSVE--QALLLREGPP 264
LL + A+ G + L +A ++++ + LL R G P
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Score = 89.0 bits (219), Expect = 5e-18
Identities = 64/204 (31%), Positives = 99/204 (48%), Gaps = 2/204 (0%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A L +K L+ +G + + N + LH A V A++LL+ G N
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 164
+V G TPL A G A V +LL A L +P+H + GH ++L+ +
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 223
V +D TPL+VA Y + VK LL+ A V+ L +PLH AA+Q + +++
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
Query: 224 HLLTDYGANLKRRNAQGKSALDLA 247
LL GA+ ++ G + L +A
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIA 774
Score = 82.8 bits (203), Expect = 3e-16
Identities = 61/220 (27%), Positives = 100/220 (45%), Gaps = 3/220 (1%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH AA G++ + L+ + + N N ++ LH A ++ K LL G +
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE-VHLASPIHEAVKRGHRECMEILLAN 164
+G TPL A LL++G A E V +P+H A + GH E + +LL+
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 223
N + TPL++ V L++ G VD + TPLH A+ N++++
Sbjct: 658 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 717
Query: 224 HLLTDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREG 262
L + A++ + G S L AA + + LLL+ G
Sbjct: 718 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 757
Score = 75.1 bits (183), Expect = 7e-14
Identities = 78/283 (27%), Positives = 113/283 (39%), Gaps = 67/283 (23%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVT----------------------IN------- 76
+PL+ AA + L +K L+ G N N+ T IN
Sbjct: 113 TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 172
Query: 77 RVSSLHEACLGGHVACAKALLEN---------------------------------GAHV 103
R+ +LH A A LL+N GA V
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232
Query: 104 NGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILL 162
N +G TPL A G+ V +LL+ GA+ + + +P+H A + GH EILL
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
Query: 163 ANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 220
+ I + +P+++A +DCV+ LL+ A +D LD TPLH AA +
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID-DITLDHLTPLHVAAHCGHH 351
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREG 262
V +L D GA R G + L +A K+ V LLL+ G
Sbjct: 352 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 394
Score = 63.2 bits (152), Expect = 3e-10
Identities = 57/210 (27%), Positives = 84/210 (40%), Gaps = 4/210 (1%)
Query: 51 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHG 110
AA G L + GV++N N ++ LH A GHV LL + T G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 111 ATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLANNVNID 169
T L A +G V L+ +GA + +P++ A + H E ++ LL N N +
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 170 HEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDY 229
TPL VA + V L+ G G+ LH AAR + +L
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHLINYGTK---GKVRLPALHIAARNDDTRTAAVLLQN 195
Query: 230 GANLKRRNAQGKSALDLAAPKSSVEQALLL 259
N + G + L +AA ++ A LL
Sbjct: 196 DPNPDVLSKTGFTPLHIAAHYENLNVAQLL 225
Score = 50.4 bits (119), Expect = 2e-06
Identities = 36/117 (30%), Positives = 56/117 (47%), Gaps = 1/117 (0%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A +G + LI GV V+ T + LH A G++ K LL++ A VN
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEIL 161
T G +PL A G V +LL+ GA ++ +P+ A + G+ ++L
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 35.4 bits (80), Expect = 0.062
Identities = 19/54 (35%), Positives = 31/54 (57%)
Query: 208 DTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 261
+T LH AA EV+ L +YGAN+ ++ +G + L +AA ++ +E L E
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 102 bits (254), Expect = 4e-22
Identities = 79/249 (31%), Positives = 107/249 (42%), Gaps = 35/249 (14%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A+ G L +K L+ +G + N+ + + LH A GH AK LL+N A VN
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQL-------EVHLA--------------- 143
TPL A G V +LLE A L +H+A
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525
Query: 144 ------------SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCV 191
+P+H A K G E+LL + + + TPL+VA + +D V
Sbjct: 526 EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIV 585
Query: 192 KKLLELGASVDHGQWLD-TPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPK 250
K LL G S W TPLH AA+Q+ VEV L YG + + QG + L LAA +
Sbjct: 586 KLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE 645
Query: 251 SSVEQALLL 259
E LL
Sbjct: 646 GHAEMVALL 654
Score = 97.4 bits (241), Expect = 1e-20
Identities = 61/216 (28%), Positives = 109/216 (50%), Gaps = 2/216 (0%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A+ +G ++ ++ L+ +G + T + ++ LH A GHV ++ LL++GA +
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEILLAN 164
T +G +P+ A CV +LL++ A+ + + +P+H A GH ++LL
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 223
+ TPL++AC V ++ LL+ GAS+D TPLH A+ ++ ++
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 224 HLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 259
L GA+ N + ++ L +AA E A L
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Score = 95.9 bits (237), Expect = 4e-20
Identities = 72/219 (32%), Positives = 106/219 (48%), Gaps = 5/219 (2%)
Query: 48 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVT 107
LH AA G+ ++ L+ G NVN + + L+ A H+ K LLENGA+ N T
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 108 VHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVN 167
G TPL A G V L+ +G K ++ + +H A + +LL N+ N
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRL---PALHIAARNDDTRTAAVLLQNDPN 198
Query: 168 IDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLL 226
D TPL++A Y+ ++ + LL GASV+ Q TPLH A+R+ NV ++ LL
Sbjct: 199 PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
Query: 227 TDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREGPP 264
D GA ++ + + L AA V +LL G P
Sbjct: 259 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297
Score = 94.4 bits (233), Expect = 1e-19
Identities = 79/250 (31%), Positives = 121/250 (48%), Gaps = 10/250 (4%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH AA L + L+ +G +VN N ++ LH A G+V + LL+ GA +
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 164
T TPL A +G +LL+ GA Q + + SPIH A + H +C+ +LL
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 327
Query: 165 NVNIDHEVPQLGTPLYVA--CTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 220
+ ID TPL+VA C + RV K LL+ GA + + L+ TPLH A ++++V
Sbjct: 328 DAEIDDITLDHLTPLHVAAHCGHHRV--AKVLLDKGAK-PNSRALNGFTPLHIACKKNHV 384
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAA--PKSSVEQALLLREGPPALSQLCRLCVRKCL 278
V+ LL GA++ G + L +A+ + + LL R P +S +
Sbjct: 385 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
Query: 279 GRACHQAIHK 288
RA H + K
Sbjct: 445 ARAGHTEVAK 454
Score = 90.5 bits (223), Expect = 2e-18
Identities = 69/223 (30%), Positives = 107/223 (47%), Gaps = 4/223 (1%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A + + ++ L+ G +++ VT + ++ LH A GH+ K LL+ GA N
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 164
V TPL A +G LL+ AK + +P+H A + GH +++LL N
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGAS-VDHGQWLDTPLHAAARQSNVEVI 223
N N + TPL++A V+ V LLE AS + TPLH AA+ V V
Sbjct: 493 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 552
Query: 224 HLLTDYGANLKRRNAQGKSALDLAAPKSSVE--QALLLREGPP 264
LL + A+ G + L +A ++++ + LL R G P
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Score = 89.0 bits (219), Expect = 5e-18
Identities = 64/204 (31%), Positives = 99/204 (48%), Gaps = 2/204 (0%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A L +K L+ +G + + N + LH A V A++LL+ G N
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 164
+V G TPL A G A V +LL A L +P+H + GH ++L+ +
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 223
V +D TPL+VA Y + VK LL+ A V+ L +PLH AA+Q + +++
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
Query: 224 HLLTDYGANLKRRNAQGKSALDLA 247
LL GA+ ++ G + L +A
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIA 774
Score = 82.8 bits (203), Expect = 3e-16
Identities = 61/220 (27%), Positives = 100/220 (45%), Gaps = 3/220 (1%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH AA G++ + L+ + + N N ++ LH A ++ K LL G +
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE-VHLASPIHEAVKRGHRECMEILLAN 164
+G TPL A LL++G A E V +P+H A + GH E + +LL+
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 223
N + TPL++ V L++ G VD + TPLH A+ N++++
Sbjct: 658 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 717
Query: 224 HLLTDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREG 262
L + A++ + G S L AA + + LLL+ G
Sbjct: 718 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 757
Score = 75.1 bits (183), Expect = 7e-14
Identities = 78/283 (27%), Positives = 113/283 (39%), Gaps = 67/283 (23%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVT----------------------IN------- 76
+PL+ AA + L +K L+ G N N+ T IN
Sbjct: 113 TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 172
Query: 77 RVSSLHEACLGGHVACAKALLEN---------------------------------GAHV 103
R+ +LH A A LL+N GA V
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232
Query: 104 NGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILL 162
N +G TPL A G+ V +LL+ GA+ + + +P+H A + GH EILL
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
Query: 163 ANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 220
+ I + +P+++A +DCV+ LL+ A +D LD TPLH AA +
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID-DITLDHLTPLHVAAHCGHH 351
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREG 262
V +L D GA R G + L +A K+ V LLL+ G
Sbjct: 352 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 394
Score = 63.2 bits (152), Expect = 3e-10
Identities = 57/210 (27%), Positives = 84/210 (40%), Gaps = 4/210 (1%)
Query: 51 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHG 110
AA G L + GV++N N ++ LH A GHV LL + T G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 111 ATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLANNVNID 169
T L A +G V L+ +GA + +P++ A + H E ++ LL N N +
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 170 HEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDY 229
TPL VA + V L+ G G+ LH AAR + +L
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHLINYGTK---GKVRLPALHIAARNDDTRTAAVLLQN 195
Query: 230 GANLKRRNAQGKSALDLAAPKSSVEQALLL 259
N + G + L +AA ++ A LL
Sbjct: 196 DPNPDVLSKTGFTPLHIAAHYENLNVAQLL 225
Score = 50.4 bits (119), Expect = 2e-06
Identities = 36/117 (30%), Positives = 56/117 (47%), Gaps = 1/117 (0%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A +G + LI GV V+ T + LH A G++ K LL++ A VN
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEIL 161
T G +PL A G V +LL+ GA ++ +P+ A + G+ ++L
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 35.4 bits (80), Expect = 0.062
Identities = 19/54 (35%), Positives = 31/54 (57%)
Query: 208 DTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 261
+T LH AA EV+ L +YGAN+ ++ +G + L +AA ++ +E L E
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 102 bits (254), Expect = 4e-22
Identities = 79/249 (31%), Positives = 107/249 (42%), Gaps = 35/249 (14%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A+ G L +K L+ +G + N+ + + LH A GH AK LL+N A VN
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQL-------EVHLA--------------- 143
TPL A G V +LLE A L +H+A
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525
Query: 144 ------------SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCV 191
+P+H A K G E+LL + + + TPL+VA + +D V
Sbjct: 526 EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIV 585
Query: 192 KKLLELGASVDHGQWLD-TPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPK 250
K LL G S W TPLH AA+Q+ VEV L YG + + QG + L LAA +
Sbjct: 586 KLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE 645
Query: 251 SSVEQALLL 259
E LL
Sbjct: 646 GHAEMVALL 654
Score = 97.4 bits (241), Expect = 1e-20
Identities = 61/216 (28%), Positives = 109/216 (50%), Gaps = 2/216 (0%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A+ +G ++ ++ L+ +G + T + ++ LH A GHV ++ LL++GA +
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEILLAN 164
T +G +P+ A CV +LL++ A+ + + +P+H A GH ++LL
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 223
+ TPL++AC V ++ LL+ GAS+D TPLH A+ ++ ++
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 224 HLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 259
L GA+ N + ++ L +AA E A L
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Score = 95.9 bits (237), Expect = 4e-20
Identities = 72/219 (32%), Positives = 106/219 (48%), Gaps = 5/219 (2%)
Query: 48 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVT 107
LH AA G+ ++ L+ G NVN + + L+ A H+ K LLENGA+ N T
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 108 VHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVN 167
G TPL A G V L+ +G K ++ + +H A + +LL N+ N
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRL---PALHIAARNDDTRTAAVLLQNDPN 198
Query: 168 IDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLL 226
D TPL++A Y+ ++ + LL GASV+ Q TPLH A+R+ NV ++ LL
Sbjct: 199 PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
Query: 227 TDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREGPP 264
D GA ++ + + L AA V +LL G P
Sbjct: 259 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297
Score = 94.4 bits (233), Expect = 1e-19
Identities = 79/250 (31%), Positives = 121/250 (48%), Gaps = 10/250 (4%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH AA L + L+ +G +VN N ++ LH A G+V + LL+ GA +
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 164
T TPL A +G +LL+ GA Q + + SPIH A + H +C+ +LL
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 327
Query: 165 NVNIDHEVPQLGTPLYVA--CTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 220
+ ID TPL+VA C + RV K LL+ GA + + L+ TPLH A ++++V
Sbjct: 328 DAEIDDITLDHLTPLHVAAHCGHHRV--AKVLLDKGAK-PNSRALNGFTPLHIACKKNHV 384
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAA--PKSSVEQALLLREGPPALSQLCRLCVRKCL 278
V+ LL GA++ G + L +A+ + + LL R P +S +
Sbjct: 385 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
Query: 279 GRACHQAIHK 288
RA H + K
Sbjct: 445 ARAGHTEVAK 454
Score = 90.5 bits (223), Expect = 2e-18
Identities = 69/223 (30%), Positives = 107/223 (47%), Gaps = 4/223 (1%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A + + ++ L+ G +++ VT + ++ LH A GH+ K LL+ GA N
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 164
V TPL A +G LL+ AK + +P+H A + GH +++LL N
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGAS-VDHGQWLDTPLHAAARQSNVEVI 223
N N + TPL++A V+ V LLE AS + TPLH AA+ V V
Sbjct: 493 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 552
Query: 224 HLLTDYGANLKRRNAQGKSALDLAAPKSSVE--QALLLREGPP 264
LL + A+ G + L +A ++++ + LL R G P
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Score = 89.0 bits (219), Expect = 5e-18
Identities = 64/204 (31%), Positives = 99/204 (48%), Gaps = 2/204 (0%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A L +K L+ +G + + N + LH A V A++LL+ G N
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 164
+V G TPL A G A V +LL A L +P+H + GH ++L+ +
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 223
V +D TPL+VA Y + VK LL+ A V+ L +PLH AA+Q + +++
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
Query: 224 HLLTDYGANLKRRNAQGKSALDLA 247
LL GA+ ++ G + L +A
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIA 774
Score = 82.8 bits (203), Expect = 3e-16
Identities = 61/220 (27%), Positives = 100/220 (45%), Gaps = 3/220 (1%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH AA G++ + L+ + + N N ++ LH A ++ K LL G +
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE-VHLASPIHEAVKRGHRECMEILLAN 164
+G TPL A LL++G A E V +P+H A + GH E + +LL+
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 223
N + TPL++ V L++ G VD + TPLH A+ N++++
Sbjct: 658 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 717
Query: 224 HLLTDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREG 262
L + A++ + G S L AA + + LLL+ G
Sbjct: 718 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 757
Score = 75.1 bits (183), Expect = 7e-14
Identities = 78/283 (27%), Positives = 113/283 (39%), Gaps = 67/283 (23%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVT----------------------IN------- 76
+PL+ AA + L +K L+ G N N+ T IN
Sbjct: 113 TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 172
Query: 77 RVSSLHEACLGGHVACAKALLEN---------------------------------GAHV 103
R+ +LH A A LL+N GA V
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232
Query: 104 NGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILL 162
N +G TPL A G+ V +LL+ GA+ + + +P+H A + GH EILL
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
Query: 163 ANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 220
+ I + +P+++A +DCV+ LL+ A +D LD TPLH AA +
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID-DITLDHLTPLHVAAHCGHH 351
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREG 262
V +L D GA R G + L +A K+ V LLL+ G
Sbjct: 352 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 394
Score = 63.2 bits (152), Expect = 3e-10
Identities = 57/210 (27%), Positives = 84/210 (40%), Gaps = 4/210 (1%)
Query: 51 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHG 110
AA G L + GV++N N ++ LH A GHV LL + T G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 111 ATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLANNVNID 169
T L A +G V L+ +GA + +P++ A + H E ++ LL N N +
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 170 HEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDY 229
TPL VA + V L+ G G+ LH AAR + +L
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHLINYGTK---GKVRLPALHIAARNDDTRTAAVLLQN 195
Query: 230 GANLKRRNAQGKSALDLAAPKSSVEQALLL 259
N + G + L +AA ++ A LL
Sbjct: 196 DPNPDVLSKTGFTPLHIAAHYENLNVAQLL 225
Score = 50.4 bits (119), Expect = 2e-06
Identities = 36/117 (30%), Positives = 56/117 (47%), Gaps = 1/117 (0%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A +G + LI GV V+ T + LH A G++ K LL++ A VN
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEIL 161
T G +PL A G V +LL+ GA ++ +P+ A + G+ ++L
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 35.4 bits (80), Expect = 0.062
Identities = 19/54 (35%), Positives = 31/54 (57%)
Query: 208 DTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 261
+T LH AA EV+ L +YGAN+ ++ +G + L +AA ++ +E L E
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 99.0 bits (245), Expect = 5e-21
Identities = 73/232 (31%), Positives = 114/232 (49%), Gaps = 15/232 (6%)
Query: 48 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVT 107
LH A+ G+ +K L+ +G N+N + N + L+ A H+ K LLENGA+ + T
Sbjct: 80 LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTAT 139
Query: 108 VHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVN 167
G TPL A G V +LLE K ++ + +H A ++ + +LL N+ N
Sbjct: 140 EDGFTPLAVALQQGHNQAVAILLENDTKGKVRL---PALHIAARKDDTKSAALLLQNDHN 196
Query: 168 IDHEVPQL--------GTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQS 218
D + + TPL++A Y V+ LL GA+VD + TPLH A+++
Sbjct: 197 ADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRG 256
Query: 219 NVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQA--LLLREGPPALSQ 268
N ++ LL D G + + G + L AA +S +Q LLL G P L++
Sbjct: 257 NTNMVKLLLDRGGQIDAKTRDGLTPLHCAA-RSGHDQVVELLLERGAPLLAR 307
Score = 97.8 bits (242), Expect = 1e-20
Identities = 71/224 (31%), Positives = 111/224 (49%), Gaps = 2/224 (0%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
SPLH AA + +K L+ V+ VT++ +++LH A GH K LL+ A+ N
Sbjct: 313 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 372
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 164
++G TPL AC + +L+++GA Q +PIH A GH + +LL N
Sbjct: 373 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN 432
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQSNVEVI 223
+ D + T L++A +V+ V+ LL GA VD + TPLH A+R E++
Sbjct: 433 GASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIV 492
Query: 224 HLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALS 267
LL + A+ G + L ++A + V+ A +L E A S
Sbjct: 493 QLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 536
Score = 92.8 bits (229), Expect = 3e-19
Identities = 71/219 (32%), Positives = 110/219 (50%), Gaps = 8/219 (3%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH AA G + L+ +G V+ N ++ LH A G+ K LL+ G ++
Sbjct: 214 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 273
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 164
T G TPL A SG V +LLE GA + SP+H A + H EC++ LL +
Sbjct: 274 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 333
Query: 165 NVNIDHEVPQLGTPLYVA--CTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 220
+D T L+VA C + RV K LL+ A+ + + L+ TPLH A +++ +
Sbjct: 334 KAPVDDVTLDYLTALHVAAHCGHYRV--TKLLLDKRAN-PNARALNGFTPLHIACKKNRI 390
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 259
+V+ LL YGA+++ G + + +AA + LLL
Sbjct: 391 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 429
Score = 90.9 bits (224), Expect = 1e-18
Identities = 64/218 (29%), Positives = 103/218 (47%), Gaps = 2/218 (0%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A + R+ ++ L+ G ++ +T + ++ +H A GH+ LL+NGA +
Sbjct: 379 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 438
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 164
+ G T L A +G V LL GA +P+H A + G E +++LL +
Sbjct: 439 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 498
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 223
+ D TPL+++ +VD LLE GA+ TPLH AA+ +++V
Sbjct: 499 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA 558
Query: 224 HLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 261
LL A G + L +AA + + ALLL E
Sbjct: 559 KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 596
Score = 89.0 bits (219), Expect = 5e-18
Identities = 67/215 (31%), Positives = 99/215 (46%), Gaps = 4/215 (1%)
Query: 48 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVT 107
LH AA G++ ++ L+ G V+ + LH A G + LL++ AH + T
Sbjct: 447 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 506
Query: 108 VHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLANNV 166
+G TPL + G +VLLE GA L +P+H A K G + ++LL
Sbjct: 507 TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 566
Query: 167 NIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNVEVIH 224
D TPL+VA Y LLE GAS H + TPLH AA+++ +++
Sbjct: 567 AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS-PHATAKNGYTPLHIAAKKNQMQIAS 625
Query: 225 LLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 259
L +YGA QG + L LA+ + + LL
Sbjct: 626 TLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 660
Score = 87.4 bits (215), Expect = 1e-17
Identities = 74/259 (28%), Positives = 109/259 (42%), Gaps = 18/259 (6%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH AA L+ +G + + N + LH A + A LL GA N
Sbjct: 577 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 636
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 164
VT G TPL A G V +LL+ GA + + +H A + +IL +
Sbjct: 637 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 696
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD----HGQWLDTPLHAAARQSNV 220
+ D TPL VAC Y V V LL+ GA+V+ +G TPLH AA+Q +
Sbjct: 697 GADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY---TPLHQAAQQGHT 753
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLGR 280
+I++L +GA A G +AL +A + L+ ++ K
Sbjct: 754 HIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEK---- 809
Query: 281 ACHQAIHKLHLPEPLERFL 299
HKL++PE + L
Sbjct: 810 ------HKLNVPETMTEVL 822
Score = 79.0 bits (193), Expect = 5e-15
Identities = 62/218 (28%), Positives = 103/218 (47%), Gaps = 2/218 (0%)
Query: 44 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHV 103
+++PLH A+ G+ ++ L+ + + T N + LH + G V A LLE GA
Sbjct: 476 EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH 535
Query: 104 NGVTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEILL 162
+ T G TPL A GS +LL+ A A + +P+H A +++ +LL
Sbjct: 536 SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLL 595
Query: 163 ANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQSNVE 221
+ TPL++A ++ LL GA + + TPLH A+++ + +
Sbjct: 596 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD 655
Query: 222 VIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 259
++ LL D GAN+ G ++L LAA + V A +L
Sbjct: 656 MVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADIL 693
Score = 70.9 bits (172), Expect = 1e-12
Identities = 64/218 (29%), Positives = 98/218 (44%), Gaps = 12/218 (5%)
Query: 51 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHG 110
AA G L + + G+++N N +++LH A GHV + LL G+ V+ T G
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 111 ATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLANNVNID 169
T L A +G A V VL++ GA + +P++ A + H + ++ LL N N
Sbjct: 77 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 136
Query: 170 HEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLL--T 227
TPL VA V LLE + G+ LH AAR+ + + LL
Sbjct: 137 TATEDGFTPLAVALQQGHNQAVAILLE---NDTKGKVRLPALHIAARKDDTKSAALLLQN 193
Query: 228 DYGANLK------RRNAQGKSALDLAAPKSSVEQALLL 259
D+ A+++ R G + L +AA +V A LL
Sbjct: 194 DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLL 231
Score = 66.2 bits (160), Expect = 3e-11
Identities = 62/218 (28%), Positives = 94/218 (43%), Gaps = 12/218 (5%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PL+ AA + + +K L+ G N + T + + L A GH LLEN G
Sbjct: 111 TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN--DTKG 168
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHL-------ASPIHEAVKRGHRECM 158
A + +A + + + A Q ++ + +P+H A G+
Sbjct: 169 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 228
Query: 159 EILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAAR 216
+LL +D TPL+VA + VK LL+ G +D + D TPLH AAR
Sbjct: 229 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQID-AKTRDGLTPLHCAAR 287
Query: 217 QSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVE 254
+ +V+ LL + GA L R G S L +AA VE
Sbjct: 288 SGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVE 325
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 99.0 bits (245), Expect = 5e-21
Identities = 73/232 (31%), Positives = 114/232 (49%), Gaps = 15/232 (6%)
Query: 48 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVT 107
LH A+ G+ +K L+ +G N+N + N + L+ A H+ K LLENGA+ + T
Sbjct: 101 LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTAT 160
Query: 108 VHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVN 167
G TPL A G V +LLE K ++ + +H A ++ + +LL N+ N
Sbjct: 161 EDGFTPLAVALQQGHNQAVAILLENDTKGKVRL---PALHIAARKDDTKSAALLLQNDHN 217
Query: 168 IDHEVPQL--------GTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQS 218
D + + TPL++A Y V+ LL GA+VD + TPLH A+++
Sbjct: 218 ADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRG 277
Query: 219 NVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQA--LLLREGPPALSQ 268
N ++ LL D G + + G + L AA +S +Q LLL G P L++
Sbjct: 278 NTNMVKLLLDRGGQIDAKTRDGLTPLHCAA-RSGHDQVVELLLERGAPLLAR 328
Score = 97.8 bits (242), Expect = 1e-20
Identities = 71/224 (31%), Positives = 111/224 (49%), Gaps = 2/224 (0%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
SPLH AA + +K L+ V+ VT++ +++LH A GH K LL+ A+ N
Sbjct: 334 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 393
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 164
++G TPL AC + +L+++GA Q +PIH A GH + +LL N
Sbjct: 394 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN 453
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQSNVEVI 223
+ D + T L++A +V+ V+ LL GA VD + TPLH A+R E++
Sbjct: 454 GASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIV 513
Query: 224 HLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALS 267
LL + A+ G + L ++A + V+ A +L E A S
Sbjct: 514 QLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557
Score = 92.8 bits (229), Expect = 3e-19
Identities = 71/219 (32%), Positives = 110/219 (50%), Gaps = 8/219 (3%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH AA G + L+ +G V+ N ++ LH A G+ K LL+ G ++
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 164
T G TPL A SG V +LLE GA + SP+H A + H EC++ LL +
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354
Query: 165 NVNIDHEVPQLGTPLYVA--CTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 220
+D T L+VA C + RV K LL+ A+ + + L+ TPLH A +++ +
Sbjct: 355 KAPVDDVTLDYLTALHVAAHCGHYRV--TKLLLDKRAN-PNARALNGFTPLHIACKKNRI 411
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 259
+V+ LL YGA+++ G + + +AA + LLL
Sbjct: 412 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450
Score = 90.9 bits (224), Expect = 1e-18
Identities = 64/218 (29%), Positives = 103/218 (47%), Gaps = 2/218 (0%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A + R+ ++ L+ G ++ +T + ++ +H A GH+ LL+NGA +
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 164
+ G T L A +G V LL GA +P+H A + G E +++LL +
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 223
+ D TPL+++ +VD LLE GA+ TPLH AA+ +++V
Sbjct: 520 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA 579
Query: 224 HLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 261
LL A G + L +AA + + ALLL E
Sbjct: 580 KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 617
Score = 89.0 bits (219), Expect = 5e-18
Identities = 67/215 (31%), Positives = 99/215 (46%), Gaps = 4/215 (1%)
Query: 48 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVT 107
LH AA G++ ++ L+ G V+ + LH A G + LL++ AH + T
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 527
Query: 108 VHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLANNV 166
+G TPL + G +VLLE GA L +P+H A K G + ++LL
Sbjct: 528 TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 587
Query: 167 NIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNVEVIH 224
D TPL+VA Y LLE GAS H + TPLH AA+++ +++
Sbjct: 588 AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS-PHATAKNGYTPLHIAAKKNQMQIAS 646
Query: 225 LLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 259
L +YGA QG + L LA+ + + LL
Sbjct: 647 TLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Score = 87.4 bits (215), Expect = 1e-17
Identities = 74/259 (28%), Positives = 109/259 (42%), Gaps = 18/259 (6%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH AA L+ +G + + N + LH A + A LL GA N
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 164
VT G TPL A G V +LL+ GA + + +H A + +IL +
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 717
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD----HGQWLDTPLHAAARQSNV 220
+ D TPL VAC Y V V LL+ GA+V+ +G TPLH AA+Q +
Sbjct: 718 GADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY---TPLHQAAQQGHT 774
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLGR 280
+I++L +GA A G +AL +A + L+ ++ K
Sbjct: 775 HIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEK---- 830
Query: 281 ACHQAIHKLHLPEPLERFL 299
HKL++PE + L
Sbjct: 831 ------HKLNVPETMTEVL 843
Score = 79.0 bits (193), Expect = 5e-15
Identities = 62/218 (28%), Positives = 103/218 (47%), Gaps = 2/218 (0%)
Query: 44 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHV 103
+++PLH A+ G+ ++ L+ + + T N + LH + G V A LLE GA
Sbjct: 497 EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH 556
Query: 104 NGVTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEILL 162
+ T G TPL A GS +LL+ A A + +P+H A +++ +LL
Sbjct: 557 SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLL 616
Query: 163 ANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQSNVE 221
+ TPL++A ++ LL GA + + TPLH A+++ + +
Sbjct: 617 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD 676
Query: 222 VIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 259
++ LL D GAN+ G ++L LAA + V A +L
Sbjct: 677 MVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADIL 714
Score = 70.9 bits (172), Expect = 1e-12
Identities = 64/218 (29%), Positives = 98/218 (44%), Gaps = 12/218 (5%)
Query: 51 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHG 110
AA G L + + G+++N N +++LH A GHV + LL G+ V+ T G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 111 ATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLANNVNID 169
T L A +G A V VL++ GA + +P++ A + H + ++ LL N N
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157
Query: 170 HEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLL--T 227
TPL VA V LLE + G+ LH AAR+ + + LL
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAILLE---NDTKGKVRLPALHIAARKDDTKSAALLLQN 214
Query: 228 DYGANLK------RRNAQGKSALDLAAPKSSVEQALLL 259
D+ A+++ R G + L +AA +V A LL
Sbjct: 215 DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLL 252
Score = 66.2 bits (160), Expect = 3e-11
Identities = 62/218 (28%), Positives = 94/218 (43%), Gaps = 12/218 (5%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PL+ AA + + +K L+ G N + T + + L A GH LLEN G
Sbjct: 132 TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN--DTKG 189
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHL-------ASPIHEAVKRGHRECM 158
A + +A + + + A Q ++ + +P+H A G+
Sbjct: 190 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 249
Query: 159 EILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAAR 216
+LL +D TPL+VA + VK LL+ G +D + D TPLH AAR
Sbjct: 250 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQID-AKTRDGLTPLHCAAR 308
Query: 217 QSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVE 254
+ +V+ LL + GA L R G S L +AA VE
Sbjct: 309 SGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVE 346
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 99.0 bits (245), Expect = 5e-21
Identities = 73/232 (31%), Positives = 114/232 (49%), Gaps = 15/232 (6%)
Query: 48 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVT 107
LH A+ G+ +K L+ +G N+N + N + L+ A H+ K LLENGA+ + T
Sbjct: 101 LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTAT 160
Query: 108 VHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVN 167
G TPL A G V +LLE K ++ + +H A ++ + +LL N+ N
Sbjct: 161 EDGFTPLAVALQQGHNQAVAILLENDTKGKVRL---PALHIAARKDDTKSAALLLQNDHN 217
Query: 168 IDHEVPQL--------GTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQS 218
D + + TPL++A Y V+ LL GA+VD + TPLH A+++
Sbjct: 218 ADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRG 277
Query: 219 NVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQA--LLLREGPPALSQ 268
N ++ LL D G + + G + L AA +S +Q LLL G P L++
Sbjct: 278 NTNMVKLLLDRGGQIDAKTRDGLTPLHCAA-RSGHDQVVELLLERGAPLLAR 328
Score = 97.8 bits (242), Expect = 1e-20
Identities = 71/224 (31%), Positives = 111/224 (49%), Gaps = 2/224 (0%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
SPLH AA + +K L+ V+ VT++ +++LH A GH K LL+ A+ N
Sbjct: 334 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 393
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 164
++G TPL AC + +L+++GA Q +PIH A GH + +LL N
Sbjct: 394 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN 453
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQSNVEVI 223
+ D + T L++A +V+ V+ LL GA VD + TPLH A+R E++
Sbjct: 454 GASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIV 513
Query: 224 HLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALS 267
LL + A+ G + L ++A + V+ A +L E A S
Sbjct: 514 QLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557
Score = 92.8 bits (229), Expect = 3e-19
Identities = 71/219 (32%), Positives = 110/219 (50%), Gaps = 8/219 (3%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH AA G + L+ +G V+ N ++ LH A G+ K LL+ G ++
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 164
T G TPL A SG V +LLE GA + SP+H A + H EC++ LL +
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354
Query: 165 NVNIDHEVPQLGTPLYVA--CTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 220
+D T L+VA C + RV K LL+ A+ + + L+ TPLH A +++ +
Sbjct: 355 KAPVDDVTLDYLTALHVAAHCGHYRV--TKLLLDKRAN-PNARALNGFTPLHIACKKNRI 411
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 259
+V+ LL YGA+++ G + + +AA + LLL
Sbjct: 412 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450
Score = 90.9 bits (224), Expect = 1e-18
Identities = 64/218 (29%), Positives = 103/218 (47%), Gaps = 2/218 (0%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A + R+ ++ L+ G ++ +T + ++ +H A GH+ LL+NGA +
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 164
+ G T L A +G V LL GA +P+H A + G E +++LL +
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 223
+ D TPL+++ +VD LLE GA+ TPLH AA+ +++V
Sbjct: 520 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA 579
Query: 224 HLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 261
LL A G + L +AA + + ALLL E
Sbjct: 580 KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 617
Score = 89.0 bits (219), Expect = 5e-18
Identities = 67/215 (31%), Positives = 99/215 (46%), Gaps = 4/215 (1%)
Query: 48 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVT 107
LH AA G++ ++ L+ G V+ + LH A G + LL++ AH + T
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 527
Query: 108 VHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLANNV 166
+G TPL + G +VLLE GA L +P+H A K G + ++LL
Sbjct: 528 TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 587
Query: 167 NIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNVEVIH 224
D TPL+VA Y LLE GAS H + TPLH AA+++ +++
Sbjct: 588 AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS-PHATAKNGYTPLHIAAKKNQMQIAS 646
Query: 225 LLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 259
L +YGA QG + L LA+ + + LL
Sbjct: 647 TLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Score = 87.4 bits (215), Expect = 1e-17
Identities = 74/259 (28%), Positives = 109/259 (42%), Gaps = 18/259 (6%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH AA L+ +G + + N + LH A + A LL GA N
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 164
VT G TPL A G V +LL+ GA + + +H A + +IL +
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 717
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD----HGQWLDTPLHAAARQSNV 220
+ D TPL VAC Y V V LL+ GA+V+ +G TPLH AA+Q +
Sbjct: 718 GADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY---TPLHQAAQQGHT 774
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLGR 280
+I++L +GA A G +AL +A + L+ ++ K
Sbjct: 775 HIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEK---- 830
Query: 281 ACHQAIHKLHLPEPLERFL 299
HKL++PE + L
Sbjct: 831 ------HKLNVPETMTEVL 843
Score = 79.0 bits (193), Expect = 5e-15
Identities = 62/218 (28%), Positives = 103/218 (47%), Gaps = 2/218 (0%)
Query: 44 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHV 103
+++PLH A+ G+ ++ L+ + + T N + LH + G V A LLE GA
Sbjct: 497 EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH 556
Query: 104 NGVTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEILL 162
+ T G TPL A GS +LL+ A A + +P+H A +++ +LL
Sbjct: 557 SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLL 616
Query: 163 ANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQSNVE 221
+ TPL++A ++ LL GA + + TPLH A+++ + +
Sbjct: 617 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD 676
Query: 222 VIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 259
++ LL D GAN+ G ++L LAA + V A +L
Sbjct: 677 MVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADIL 714
Score = 70.9 bits (172), Expect = 1e-12
Identities = 64/218 (29%), Positives = 98/218 (44%), Gaps = 12/218 (5%)
Query: 51 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHG 110
AA G L + + G+++N N +++LH A GHV + LL G+ V+ T G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 111 ATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLANNVNID 169
T L A +G A V VL++ GA + +P++ A + H + ++ LL N N
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157
Query: 170 HEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLL--T 227
TPL VA V LLE + G+ LH AAR+ + + LL
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAILLE---NDTKGKVRLPALHIAARKDDTKSAALLLQN 214
Query: 228 DYGANLK------RRNAQGKSALDLAAPKSSVEQALLL 259
D+ A+++ R G + L +AA +V A LL
Sbjct: 215 DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLL 252
Score = 66.2 bits (160), Expect = 3e-11
Identities = 62/218 (28%), Positives = 94/218 (43%), Gaps = 12/218 (5%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PL+ AA + + +K L+ G N + T + + L A GH LLEN G
Sbjct: 132 TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN--DTKG 189
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHL-------ASPIHEAVKRGHRECM 158
A + +A + + + A Q ++ + +P+H A G+
Sbjct: 190 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 249
Query: 159 EILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAAR 216
+LL +D TPL+VA + VK LL+ G +D + D TPLH AAR
Sbjct: 250 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQID-AKTRDGLTPLHCAAR 308
Query: 217 QSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVE 254
+ +V+ LL + GA L R G S L +AA VE
Sbjct: 309 SGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVE 346
>gi|94721248 ankyrin repeat and SOCS box-containing protein 1 [Homo
sapiens]
Length = 335
Score = 98.6 bits (244), Expect = 6e-21
Identities = 76/277 (27%), Positives = 122/277 (44%), Gaps = 33/277 (11%)
Query: 42 WADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGA 101
W +PL AA G + LI +G V+LV + ++L+ A + GH+ + LLE GA
Sbjct: 76 WLPCTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGA 135
Query: 102 HVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEIL 161
NG H +TP+++A G A + L+ +GA + HL + R R ++
Sbjct: 136 DPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQ---PRFSRRLTSLV 192
Query: 162 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD---------HGQWLDTP-- 210
+ PLY++ Y + C + LL GA+ D G + +P
Sbjct: 193 VC--------------PLYISAAYHNLQCFRLLLLAGANPDFNCNGPVNTQGFYRGSPGC 238
Query: 211 -LHAAARQS-NVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREG---PPA 265
+ A R + LL ++GANL + K E + +E P
Sbjct: 239 VMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGPESRGRRKVDPEALQVFKEARSVPRT 298
Query: 266 LSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ 302
L LCR+ VR+ LG+ I L LP+P+++FLL++
Sbjct: 299 LLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLLHE 335
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 97.4 bits (241), Expect = 1e-20
Identities = 74/223 (33%), Positives = 111/223 (49%), Gaps = 4/223 (1%)
Query: 44 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHV 103
D +PL AA G + +K L+A +VN + ++L AC GG+V K LLE+GA +
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
Query: 104 NGVTVHGATPLFNACCSGSAACVNVLLEFGA--KAQLEVHLASPIHEAVKRGHRECMEIL 161
+G TPL A +G +LLE GA S + A +GH E + L
Sbjct: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420
Query: 162 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQSNV 220
L + +H+ ++ T L AC V+ + LL+ GA V+ ++PL AA +V
Sbjct: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQ-ALLLREG 262
E+ LL + GA+L+ N +G + L AA + E ALLL +G
Sbjct: 481 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQG 523
Score = 93.2 bits (230), Expect = 3e-19
Identities = 70/221 (31%), Positives = 112/221 (50%), Gaps = 7/221 (3%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
S L A +G L ++ L+ G + T ++L EAC+ GHV A+ LL++GA VN
Sbjct: 403 SALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 462
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA--SPIHEAVKRGHRECMEILLA 163
+PL A C G +L+E GA + EV+ +P+ EA + GH E + +LL
Sbjct: 463 PADSFESPLTLAACGGHVELAALLIERGASLE-EVNDEGYTPLMEAAREGHEEMVALLLG 521
Query: 164 NNVNIDHEVPQLG-TPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEV 222
NI+ + + T L +AC ++ L++ GA ++ G TPL AA++ ++E+
Sbjct: 522 QGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELG--CSTPLMEAAQEGHLEL 579
Query: 223 IHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQA-LLLREG 262
+ L GAN+ A G +AL A + A +LL+ G
Sbjct: 580 VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAG 620
Score = 86.7 bits (213), Expect = 2e-17
Identities = 64/195 (32%), Positives = 90/195 (46%), Gaps = 4/195 (2%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
SPL AA G + LI +G ++ V + L EA GH LL GA++N
Sbjct: 469 SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA 528
Query: 106 VTVH-GATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLAN 164
T T L ACC G + L++ G A +E+ ++P+ EA + GH E ++ LLA
Sbjct: 529 QTEETQETALTLACCGGFLEVADFLIKAG--ADIELGCSTPLMEAAQEGHLELVKYLLAA 586
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVI 223
N+ T L AC D LL+ GA ++H + TPL AAR +V +
Sbjct: 587 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTV 646
Query: 224 HLLTDYGANLKRRNA 238
L GAN+ R A
Sbjct: 647 QFLISKGANVNRTTA 661
Score = 84.7 bits (208), Expect = 9e-17
Identities = 84/266 (31%), Positives = 113/266 (42%), Gaps = 41/266 (15%)
Query: 43 ADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACL---------------- 86
+D L EA ++G + A++ L+ +G +VN T S L AC
Sbjct: 233 SDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHAN 292
Query: 87 ------------------GGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNV 128
GGHV K LL + A VN + G T L AC G V V
Sbjct: 293 VEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKV 352
Query: 129 LLEFGAKAQLEVHLA---SPIHEAVKRGHRECMEILLANNVNID-HEVPQLGTPLYVACT 184
LLE G A +E H +P+ EA GH E +LL N I+ H + L +AC
Sbjct: 353 LLESG--ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACY 410
Query: 185 YQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSA 243
++ V+ LLE GA +H + T L A +VEV LL D GA + +S
Sbjct: 411 KGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESP 470
Query: 244 LDLAAPKSSVEQALLLREGPPALSQL 269
L LAA VE A LL E +L ++
Sbjct: 471 LTLAACGGHVELAALLIERGASLEEV 496
Score = 84.7 bits (208), Expect = 9e-17
Identities = 68/221 (30%), Positives = 107/221 (48%), Gaps = 7/221 (3%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PL A + GR ++ L+A+G N ++ + L A GG+V K LL GA +N
Sbjct: 1152 TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS 1211
Query: 106 VTVH--GATPLFNACCSGSAACVNVLLEFGA--KAQLEVHLASPIHEAVKRGHRECMEIL 161
T G +PL A +G A V +LL+ G+ AQ+E + + + A +G E + +L
Sbjct: 1212 RTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL 1271
Query: 162 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH---GQWLDTPLHAAARQS 218
L N++H TPL A + + + LL+ GA V+ DT L AA +
Sbjct: 1272 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1331
Query: 219 NVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 259
+ + LL GA++ RN +G + L LAA ++ LL
Sbjct: 1332 HYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1372
Score = 80.9 bits (198), Expect = 1e-15
Identities = 63/190 (33%), Positives = 92/190 (48%), Gaps = 6/190 (3%)
Query: 76 NRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGA- 134
N ++L AC GGH + LLE GA + G TPL A +G V +LL+ GA
Sbjct: 1082 NHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGAD 1141
Query: 135 -KAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKK 193
+AQ E +P+ A G +E +E+LLA N +H TPL +A + V+ +K
Sbjct: 1142 IEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1201
Query: 194 LLELGASVDH--GQWLD-TPLHAAARQSNVEVIHLLTDYGANLKRR-NAQGKSALDLAAP 249
LL GA ++ G L +PL AA + + LL D G+++ + +AL LA
Sbjct: 1202 LLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACF 1261
Query: 250 KSSVEQALLL 259
+ E LL
Sbjct: 1262 QGRTEVVSLL 1271
Score = 79.3 bits (194), Expect = 4e-15
Identities = 61/186 (32%), Positives = 89/186 (47%), Gaps = 5/186 (2%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNL-VTINRVSSLHEACLGGHVACAKALLENGAHVN 104
SPL AA G A+K L+ G ++N + NR ++L AC G LL+ A+V
Sbjct: 1220 SPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVE 1279
Query: 105 GVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLAS---PIHEAVKRGHRECMEIL 161
G TPL A G A VLL+ GA +S + A +GH + E+L
Sbjct: 1280 HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1339
Query: 162 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNV 220
+ +ID + TPL++A +D V+ L++ GA VD TPL AA R+ +V
Sbjct: 1340 IGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHV 1399
Query: 221 EVIHLL 226
+V+ L
Sbjct: 1400 KVVRYL 1405
Score = 65.1 bits (157), Expect = 7e-11
Identities = 56/184 (30%), Positives = 77/184 (41%), Gaps = 7/184 (3%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PL EAA +G L +K L+A G NV+ T ++L AC GH A LL+ GA +
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV--HLASPIHEAVKRGHRECMEILLA 163
+ G TPL A +G V L+ GA + + + A GH +E+LLA
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLA 685
Query: 164 NNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLE-----LGASVDHGQWLDTPLHAAARQS 218
+ + H + T L A V LL+ L A L P H R
Sbjct: 686 HGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAP 745
Query: 219 NVEV 222
V V
Sbjct: 746 RVPV 749
Score = 65.1 bits (157), Expect = 7e-11
Identities = 64/215 (29%), Positives = 96/215 (44%), Gaps = 6/215 (2%)
Query: 51 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHG 110
A A G ++TL+ +G ++ + L A GHV + LL+NGA + +
Sbjct: 1090 ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT 1149
Query: 111 A-TPLFNACCSGSAACVNVLLEFGA-KAQLEVHLASPIHEAVKRGHRECMEILLANNVNI 168
TPL AC G V +LL GA K V +P+ A G+ ++ILL I
Sbjct: 1150 KDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI 1209
Query: 169 DHEV-PQLG-TPLYVACTYQRVDCVKKLLELGASVDH--GQWLDTPLHAAARQSNVEVIH 224
+ +LG +PL +A VK LL++G+ ++ +T L A Q EV+
Sbjct: 1210 NSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVS 1269
Query: 225 LLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 259
LL D AN++ R G + L AA E +L
Sbjct: 1270 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1304
Score = 57.4 bits (137), Expect = 2e-08
Identities = 40/115 (34%), Positives = 57/115 (49%), Gaps = 2/115 (1%)
Query: 136 AQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLL 195
AQ E + + + A GH E ++ LL +I+H + TPL +A T V V+ LL
Sbjct: 1077 AQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILL 1136
Query: 196 ELGASVD--HGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAA 248
+ GA ++ + DTPL A EV+ LL GAN + RN + L LAA
Sbjct: 1137 DNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAA 1191
Score = 53.9 bits (128), Expect = 2e-07
Identities = 33/89 (37%), Positives = 48/89 (53%), Gaps = 1/89 (1%)
Query: 45 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSS-LHEACLGGHVACAKALLENGAHV 103
R+PL +AA G + ++ LI++G NVN T N + L AC GGH+A + LL +GA
Sbjct: 631 RTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADP 690
Query: 104 NGVTVHGATPLFNACCSGSAACVNVLLEF 132
G+T L A G + V LL++
Sbjct: 691 THRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
Score = 33.9 bits (76), Expect = 0.18
Identities = 27/116 (23%), Positives = 53/116 (45%), Gaps = 4/116 (3%)
Query: 51 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHG 110
AA +G + LI +G ++++ + L A GGH+ + L++ GA V+
Sbjct: 1327 AADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1386
Query: 111 ATPLFNACCSGSAACVNVLL----EFGAKAQLEVHLASPIHEAVKRGHRECMEILL 162
TPL A G V L+ +F + ++ ++A+ + + + CME ++
Sbjct: 1387 ITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIV 1442
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 97.4 bits (241), Expect = 1e-20
Identities = 74/223 (33%), Positives = 111/223 (49%), Gaps = 4/223 (1%)
Query: 44 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHV 103
D +PL AA G + +K L+A +VN + ++L AC GG+V K LLE+GA +
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
Query: 104 NGVTVHGATPLFNACCSGSAACVNVLLEFGA--KAQLEVHLASPIHEAVKRGHRECMEIL 161
+G TPL A +G +LLE GA S + A +GH E + L
Sbjct: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420
Query: 162 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQSNV 220
L + +H+ ++ T L AC V+ + LL+ GA V+ ++PL AA +V
Sbjct: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQ-ALLLREG 262
E+ LL + GA+L+ N +G + L AA + E ALLL +G
Sbjct: 481 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQG 523
Score = 93.2 bits (230), Expect = 3e-19
Identities = 70/221 (31%), Positives = 112/221 (50%), Gaps = 7/221 (3%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
S L A +G L ++ L+ G + T ++L EAC+ GHV A+ LL++GA VN
Sbjct: 403 SALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 462
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA--SPIHEAVKRGHRECMEILLA 163
+PL A C G +L+E GA + EV+ +P+ EA + GH E + +LL
Sbjct: 463 PADSFESPLTLAACGGHVELAALLIERGASLE-EVNDEGYTPLMEAAREGHEEMVALLLG 521
Query: 164 NNVNIDHEVPQLG-TPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEV 222
NI+ + + T L +AC ++ L++ GA ++ G TPL AA++ ++E+
Sbjct: 522 QGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELG--CSTPLMEAAQEGHLEL 579
Query: 223 IHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQA-LLLREG 262
+ L GAN+ A G +AL A + A +LL+ G
Sbjct: 580 VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAG 620
Score = 86.7 bits (213), Expect = 2e-17
Identities = 64/195 (32%), Positives = 90/195 (46%), Gaps = 4/195 (2%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
SPL AA G + LI +G ++ V + L EA GH LL GA++N
Sbjct: 469 SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA 528
Query: 106 VTVH-GATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLAN 164
T T L ACC G + L++ G A +E+ ++P+ EA + GH E ++ LLA
Sbjct: 529 QTEETQETALTLACCGGFLEVADFLIKAG--ADIELGCSTPLMEAAQEGHLELVKYLLAA 586
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVI 223
N+ T L AC D LL+ GA ++H + TPL AAR +V +
Sbjct: 587 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTV 646
Query: 224 HLLTDYGANLKRRNA 238
L GAN+ R A
Sbjct: 647 QFLISKGANVNRTTA 661
Score = 84.7 bits (208), Expect = 9e-17
Identities = 84/266 (31%), Positives = 113/266 (42%), Gaps = 41/266 (15%)
Query: 43 ADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACL---------------- 86
+D L EA ++G + A++ L+ +G +VN T S L AC
Sbjct: 233 SDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHAN 292
Query: 87 ------------------GGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNV 128
GGHV K LL + A VN + G T L AC G V V
Sbjct: 293 VEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKV 352
Query: 129 LLEFGAKAQLEVHLA---SPIHEAVKRGHRECMEILLANNVNID-HEVPQLGTPLYVACT 184
LLE G A +E H +P+ EA GH E +LL N I+ H + L +AC
Sbjct: 353 LLESG--ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACY 410
Query: 185 YQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSA 243
++ V+ LLE GA +H + T L A +VEV LL D GA + +S
Sbjct: 411 KGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESP 470
Query: 244 LDLAAPKSSVEQALLLREGPPALSQL 269
L LAA VE A LL E +L ++
Sbjct: 471 LTLAACGGHVELAALLIERGASLEEV 496
Score = 84.7 bits (208), Expect = 9e-17
Identities = 68/221 (30%), Positives = 107/221 (48%), Gaps = 7/221 (3%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PL A + GR ++ L+A+G N ++ + L A GG+V K LL GA +N
Sbjct: 901 TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS 960
Query: 106 VTVH--GATPLFNACCSGSAACVNVLLEFGA--KAQLEVHLASPIHEAVKRGHRECMEIL 161
T G +PL A +G A V +LL+ G+ AQ+E + + + A +G E + +L
Sbjct: 961 RTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL 1020
Query: 162 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH---GQWLDTPLHAAARQS 218
L N++H TPL A + + + LL+ GA V+ DT L AA +
Sbjct: 1021 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1080
Query: 219 NVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 259
+ + LL GA++ RN +G + L LAA ++ LL
Sbjct: 1081 HYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1121
Score = 80.9 bits (198), Expect = 1e-15
Identities = 63/190 (33%), Positives = 92/190 (48%), Gaps = 6/190 (3%)
Query: 76 NRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGA- 134
N ++L AC GGH + LLE GA + G TPL A +G V +LL+ GA
Sbjct: 831 NHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGAD 890
Query: 135 -KAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKK 193
+AQ E +P+ A G +E +E+LLA N +H TPL +A + V+ +K
Sbjct: 891 IEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 950
Query: 194 LLELGASVDH--GQWLD-TPLHAAARQSNVEVIHLLTDYGANLKRR-NAQGKSALDLAAP 249
LL GA ++ G L +PL AA + + LL D G+++ + +AL LA
Sbjct: 951 LLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACF 1010
Query: 250 KSSVEQALLL 259
+ E LL
Sbjct: 1011 QGRTEVVSLL 1020
Score = 79.3 bits (194), Expect = 4e-15
Identities = 61/186 (32%), Positives = 89/186 (47%), Gaps = 5/186 (2%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNL-VTINRVSSLHEACLGGHVACAKALLENGAHVN 104
SPL AA G A+K L+ G ++N + NR ++L AC G LL+ A+V
Sbjct: 969 SPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVE 1028
Query: 105 GVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLAS---PIHEAVKRGHRECMEIL 161
G TPL A G A VLL+ GA +S + A +GH + E+L
Sbjct: 1029 HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1088
Query: 162 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNV 220
+ +ID + TPL++A +D V+ L++ GA VD TPL AA R+ +V
Sbjct: 1089 IGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHV 1148
Query: 221 EVIHLL 226
+V+ L
Sbjct: 1149 KVVRYL 1154
Score = 65.1 bits (157), Expect = 7e-11
Identities = 56/184 (30%), Positives = 77/184 (41%), Gaps = 7/184 (3%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PL EAA +G L +K L+A G NV+ T ++L AC GH A LL+ GA +
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV--HLASPIHEAVKRGHRECMEILLA 163
+ G TPL A +G V L+ GA + + + A GH +E+LLA
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLA 685
Query: 164 NNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLE-----LGASVDHGQWLDTPLHAAARQS 218
+ + H + T L A V LL+ L A L P H R
Sbjct: 686 HGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAP 745
Query: 219 NVEV 222
V V
Sbjct: 746 RVPV 749
Score = 65.1 bits (157), Expect = 7e-11
Identities = 64/215 (29%), Positives = 96/215 (44%), Gaps = 6/215 (2%)
Query: 51 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHG 110
A A G ++TL+ +G ++ + L A GHV + LL+NGA + +
Sbjct: 839 ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT 898
Query: 111 A-TPLFNACCSGSAACVNVLLEFGA-KAQLEVHLASPIHEAVKRGHRECMEILLANNVNI 168
TPL AC G V +LL GA K V +P+ A G+ ++ILL I
Sbjct: 899 KDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI 958
Query: 169 DHEV-PQLG-TPLYVACTYQRVDCVKKLLELGASVDH--GQWLDTPLHAAARQSNVEVIH 224
+ +LG +PL +A VK LL++G+ ++ +T L A Q EV+
Sbjct: 959 NSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVS 1018
Query: 225 LLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 259
LL D AN++ R G + L AA E +L
Sbjct: 1019 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1053
Score = 57.4 bits (137), Expect = 2e-08
Identities = 40/115 (34%), Positives = 57/115 (49%), Gaps = 2/115 (1%)
Query: 136 AQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLL 195
AQ E + + + A GH E ++ LL +I+H + TPL +A T V V+ LL
Sbjct: 826 AQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILL 885
Query: 196 ELGASVD--HGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAA 248
+ GA ++ + DTPL A EV+ LL GAN + RN + L LAA
Sbjct: 886 DNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAA 940
Score = 56.6 bits (135), Expect = 3e-08
Identities = 59/251 (23%), Positives = 94/251 (37%), Gaps = 45/251 (17%)
Query: 45 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSS-LHEACLGGHVACAKALLENGAHV 103
R+PL +AA G + ++ LI++G NVN T N + L AC GGH+A + LL +GA
Sbjct: 631 RTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADP 690
Query: 104 NGVTVHGATPLFNACCSGSAACVNVLLEF------------------------------- 132
G+T L A G + V LL++
Sbjct: 691 THRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQ 750
Query: 133 ----------GAKAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVA 182
K V PI G M +++ PQ TP +
Sbjct: 751 ALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPII 810
Query: 183 CTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKS 242
+ + +++ A + DT L A + E++ L + GA+++ R+ +G +
Sbjct: 811 SPSAMLP-IYPAIDIDAQTESNH--DTALTLACAGGHEELVQTLLERGASIEHRDKKGFT 867
Query: 243 ALDLAAPKSSV 253
L LAA V
Sbjct: 868 PLILAATAGHV 878
Score = 33.9 bits (76), Expect = 0.18
Identities = 27/116 (23%), Positives = 53/116 (45%), Gaps = 4/116 (3%)
Query: 51 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHG 110
AA +G + LI +G ++++ + L A GGH+ + L++ GA V+
Sbjct: 1076 AADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1135
Query: 111 ATPLFNACCSGSAACVNVLL----EFGAKAQLEVHLASPIHEAVKRGHRECMEILL 162
TPL A G V L+ +F + ++ ++A+ + + + CME ++
Sbjct: 1136 ITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIV 1191
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 96.3 bits (238), Expect = 3e-20
Identities = 71/251 (28%), Positives = 113/251 (45%), Gaps = 35/251 (13%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A + R+ ++ L+ G ++ VT + ++ +H A GHV L+ +GA N
Sbjct: 402 TPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNT 461
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKA-------QLEVHLAS-------------- 144
V G T L A SG A V L++ GA+ Q +H+++
Sbjct: 462 TNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQ 521
Query: 145 -------------PIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCV 191
P+H + + GH + LL + ++ + TPL+VA Y +++
Sbjct: 522 GASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVA 581
Query: 192 KKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPK 250
LL+ AS D G+ TPLH AA N +V LL D GA+ G + L +AA K
Sbjct: 582 NLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKK 641
Query: 251 SSVEQALLLRE 261
+ ++ A L E
Sbjct: 642 NQMDIATTLLE 652
Score = 94.7 bits (234), Expect = 9e-20
Identities = 73/249 (29%), Positives = 115/249 (46%), Gaps = 35/249 (14%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
SPLH A L ++ L+ V V+ VT + +++LH A GH AK LL+ A+ N
Sbjct: 336 SPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNA 395
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAK------------------------AQLEVH 141
++G TPL AC + +LL+ GA +QL H
Sbjct: 396 KALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHH 455
Query: 142 LASP----------IHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCV 191
ASP +H A + G E + L+ + ++ + TPL+++ + D V
Sbjct: 456 GASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIV 515
Query: 192 KKLLELGASVDHGQWLD-TPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPK 250
++LL+ GAS + TPLH +AR+ + +V L D+GA+L +G + L +AA
Sbjct: 516 QQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKY 575
Query: 251 SSVEQALLL 259
+E A LL
Sbjct: 576 GKLEVANLL 584
Score = 94.0 bits (232), Expect = 1e-19
Identities = 74/254 (29%), Positives = 114/254 (44%), Gaps = 34/254 (13%)
Query: 48 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVT 107
LH A+ +G + + L+ + NV+ T ++LH A L G K L+ NGA+VN +
Sbjct: 78 LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS 137
Query: 108 VHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLANNV 166
+G TPL+ A V LL+ GA L +P+ A+++GH + + +LL N+
Sbjct: 138 QNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDT 197
Query: 167 -----------------------------NIDHEVPQLGTPLYVACTYQRVDCVKKLLEL 197
N D E TPL++A Y ++ LL
Sbjct: 198 KGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNR 257
Query: 198 GASVDHGQWLD-TPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQA 256
A+VD D TPLH A+++ N ++ LL D GA + + G + L A +S EQ
Sbjct: 258 AAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGA-RSGHEQV 316
Query: 257 --LLLREGPPALSQ 268
+LL P LS+
Sbjct: 317 VEMLLDRAAPILSK 330
Score = 92.0 bits (227), Expect = 6e-19
Identities = 70/247 (28%), Positives = 110/247 (44%), Gaps = 41/247 (16%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH AA G + L+ + V+ N ++ LH A G+ K LL+ GA ++
Sbjct: 237 TPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDA 296
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGHRECMEILLAN 164
T G TPL SG V +LL+ A + + SP+H A + H C+++LL +
Sbjct: 297 KTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQH 356
Query: 165 NVNID----------HEVPQLG-----------------------TPLYVACTYQRVDCV 191
NV +D H G TPL++AC R+ +
Sbjct: 357 NVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVM 416
Query: 192 KKLLELGASV----DHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLA 247
+ LL+ GAS+ + G TP+H AA +V ++ L +GA+ N +G++AL +A
Sbjct: 417 ELLLKHGASIQAVTESGL---TPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMA 473
Query: 248 APKSSVE 254
A E
Sbjct: 474 ARSGQAE 480
Score = 85.1 bits (209), Expect = 7e-17
Identities = 57/205 (27%), Positives = 94/205 (45%), Gaps = 2/205 (0%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH AA G+L L+ + + + + ++ LH A + A LL+ GA +
Sbjct: 567 TPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHA 626
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 164
+G TPL A LLE+GA A + +H A + GH + + +LL
Sbjct: 627 AAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGR 686
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 223
N N++ TPL++A RV+ + L+ GA VD + TPLH N++++
Sbjct: 687 NANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIV 746
Query: 224 HLLTDYGANLKRRNAQGKSALDLAA 248
+ L + A + + G + L AA
Sbjct: 747 NFLLQHSAKVNAKTKNGYTPLHQAA 771
Score = 84.3 bits (207), Expect = 1e-16
Identities = 63/218 (28%), Positives = 104/218 (47%), Gaps = 2/218 (0%)
Query: 44 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHV 103
D++PLH +A G+ ++ L+ QG + N T + + LH + GH A LL++GA +
Sbjct: 499 DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASL 558
Query: 104 NGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILL 162
+ T G TPL A G N+LL+ A +P+H A +++ +LL
Sbjct: 559 SITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLL 618
Query: 163 ANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVE 221
+ TPL++A ++D LLE GA + + +H AA++ +V+
Sbjct: 619 DQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVD 678
Query: 222 VIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 259
++ LL AN+ N G + L LAA + V A +L
Sbjct: 679 MVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVL 716
Score = 81.6 bits (200), Expect = 8e-16
Identities = 68/259 (26%), Positives = 108/259 (41%), Gaps = 19/259 (7%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH AA L+ QG + + N + LH A + A LLE GA N
Sbjct: 600 TPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANA 659
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 164
VT G + A G V++LL A L +P+H A + E+L+
Sbjct: 660 VTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQ 719
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD----HGQWLDTPLHAAARQSNV 220
++D + TPL+V C Y + V LL+ A V+ +G TPLH AA+Q +
Sbjct: 720 GAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGY---TPLHQAAQQGHT 776
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLGR 280
+I++L A+ G +AL +A R G ++ ++ + +
Sbjct: 777 HIINVLLQNNASPNELTVNGNTALGIAR-----------RLGYISVVDTLKIVTEETMTT 825
Query: 281 ACHQAIHKLHLPEPLERFL 299
HK+++PE + L
Sbjct: 826 TTVTEKHKMNVPETMNEVL 844
Score = 59.7 bits (143), Expect = 3e-09
Identities = 54/186 (29%), Positives = 83/186 (44%), Gaps = 12/186 (6%)
Query: 79 SSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQL 138
+S A GH+ A ++NG +N +G L A G V+ LL+ A
Sbjct: 43 ASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDA 102
Query: 139 EVHLA-SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLEL 197
+ +H A G E +++L+ N N++ + TPLY+A ++ VK LL+
Sbjct: 103 ATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDN 162
Query: 198 GAS----VDHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSV 253
GAS + G TPL A +Q + +V+ LL + K R AL +AA K
Sbjct: 163 GASQSLATEDG---FTPLAVALQQGHDQVVSLLLENDTKGKVR----LPALHIAARKDDT 215
Query: 254 EQALLL 259
+ A LL
Sbjct: 216 KAAALL 221
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 95.9 bits (237), Expect = 4e-20
Identities = 72/223 (32%), Positives = 109/223 (48%), Gaps = 4/223 (1%)
Query: 44 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHV 103
D +PL A++ G L +K L+ +VN + ++L AC GG V K LL GA++
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
Query: 104 NGVTVHGATPLFNACCSGSAACVNVLLEFGA--KAQLEVHLASPIHEAVKRGHRECMEIL 161
+G TPL A +G VLL+ GA S + A +GH + + L
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391
Query: 162 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQSNV 220
L + +H+ ++ T L AC V+ + LL+ GA V+ ++PL AA +V
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQ-ALLLREG 262
E+ LL + GANL+ N +G + L AA + E ALLL +G
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQG 494
Score = 92.0 bits (227), Expect = 6e-19
Identities = 70/221 (31%), Positives = 112/221 (50%), Gaps = 7/221 (3%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
S L A +G L ++ L+ G + T ++L EAC+ GHV A+ LL++GA VN
Sbjct: 374 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA--SPIHEAVKRGHRECMEILLA 163
+PL A C G +L+E GA + EV+ +P+ EA + GH E + +LLA
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIERGANLE-EVNDEGYTPLMEAAREGHEEMVALLLA 492
Query: 164 NNVNIDHEVPQLG-TPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEV 222
NI+ + + T L +AC + L++ GA ++ G TPL A+++ ++E+
Sbjct: 493 QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG--CSTPLMEASQEGHLEL 550
Query: 223 IHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQA-LLLREG 262
+ L GAN+ A G +AL A + A +LL+ G
Sbjct: 551 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
Score = 81.3 bits (199), Expect = 1e-15
Identities = 62/186 (33%), Positives = 92/186 (49%), Gaps = 4/186 (2%)
Query: 80 SLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE 139
SL EAC G V + LL+ G VN T G + L AC +G VLL A +
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
Query: 140 VHLA--SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLEL 197
+ +P+ A G+ + +++LL ++ +++ + T L AC VD VK LL
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
Query: 198 GASV-DHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGK-SALDLAAPKSSVEQ 255
GA++ DH + TPL AA +VEV +L D+GA + + + K SAL LA K ++
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387
Query: 256 ALLLRE 261
L E
Sbjct: 388 VRFLLE 393
Score = 76.6 bits (187), Expect = 2e-14
Identities = 80/257 (31%), Positives = 106/257 (41%), Gaps = 41/257 (15%)
Query: 44 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEAC------------------ 85
D L EA + G + A++ L+ +G +VN T S L AC
Sbjct: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264
Query: 86 ----------------LGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVL 129
GG++ K LL + A VN + G T L AC G V VL
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 130 LEFGAKAQLEVHLA---SPIHEAVKRGHRECMEILLANNVNID-HEVPQLGTPLYVACTY 185
L G A +E H +P+ EA GH E +LL + I+ H + L +AC
Sbjct: 325 LNEG--ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 382
Query: 186 QRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSAL 244
+D V+ LLE GA +H + T L A +VEV LL D GA + +S L
Sbjct: 383 GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 442
Query: 245 DLAAPKSSVEQALLLRE 261
LAA VE A LL E
Sbjct: 443 TLAACGGHVELAALLIE 459
Score = 75.1 bits (183), Expect = 7e-14
Identities = 54/167 (32%), Positives = 78/167 (46%), Gaps = 3/167 (1%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
SPL AA G + LI +G N+ V + L EA GH LL GA++N
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
Query: 106 VTVHGA-TPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLAN 164
T T L ACC G + + L++ GA +E+ ++P+ EA + GH E ++ LLA+
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAGA--DIELGCSTPLMEASQEGHLELVKYLLAS 557
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPL 211
N+ T L AC D LL+ GA +D + + T L
Sbjct: 558 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTIL 604
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 95.9 bits (237), Expect = 4e-20
Identities = 72/223 (32%), Positives = 109/223 (48%), Gaps = 4/223 (1%)
Query: 44 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHV 103
D +PL A++ G L +K L+ +VN + ++L AC GG V K LL GA++
Sbjct: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
Query: 104 NGVTVHGATPLFNACCSGSAACVNVLLEFGA--KAQLEVHLASPIHEAVKRGHRECMEIL 161
+G TPL A +G VLL+ GA S + A +GH + + L
Sbjct: 321 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 380
Query: 162 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQSNV 220
L + +H+ ++ T L AC V+ + LL+ GA V+ ++PL AA +V
Sbjct: 381 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 440
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQ-ALLLREG 262
E+ LL + GANL+ N +G + L AA + E ALLL +G
Sbjct: 441 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQG 483
Score = 92.0 bits (227), Expect = 6e-19
Identities = 70/221 (31%), Positives = 112/221 (50%), Gaps = 7/221 (3%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
S L A +G L ++ L+ G + T ++L EAC+ GHV A+ LL++GA VN
Sbjct: 363 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 422
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA--SPIHEAVKRGHRECMEILLA 163
+PL A C G +L+E GA + EV+ +P+ EA + GH E + +LLA
Sbjct: 423 PADSFESPLTLAACGGHVELAALLIERGANLE-EVNDEGYTPLMEAAREGHEEMVALLLA 481
Query: 164 NNVNIDHEVPQLG-TPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEV 222
NI+ + + T L +AC + L++ GA ++ G TPL A+++ ++E+
Sbjct: 482 QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG--CSTPLMEASQEGHLEL 539
Query: 223 IHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQA-LLLREG 262
+ L GAN+ A G +AL A + A +LL+ G
Sbjct: 540 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 580
Score = 81.3 bits (199), Expect = 1e-15
Identities = 62/186 (33%), Positives = 92/186 (49%), Gaps = 4/186 (2%)
Query: 80 SLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE 139
SL EAC G V + LL+ G VN T G + L AC +G VLL A +
Sbjct: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256
Query: 140 VHLA--SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLEL 197
+ +P+ A G+ + +++LL ++ +++ + T L AC VD VK LL
Sbjct: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
Query: 198 GASV-DHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGK-SALDLAAPKSSVEQ 255
GA++ DH + TPL AA +VEV +L D+GA + + + K SAL LA K ++
Sbjct: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 376
Query: 256 ALLLRE 261
L E
Sbjct: 377 VRFLLE 382
Score = 76.6 bits (187), Expect = 2e-14
Identities = 80/257 (31%), Positives = 106/257 (41%), Gaps = 41/257 (15%)
Query: 44 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEAC------------------ 85
D L EA + G + A++ L+ +G +VN T S L AC
Sbjct: 194 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 253
Query: 86 ----------------LGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVL 129
GG++ K LL + A VN + G T L AC G V VL
Sbjct: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
Query: 130 LEFGAKAQLEVHLA---SPIHEAVKRGHRECMEILLANNVNID-HEVPQLGTPLYVACTY 185
L G A +E H +P+ EA GH E +LL + I+ H + L +AC
Sbjct: 314 LNEG--ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 371
Query: 186 QRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSAL 244
+D V+ LLE GA +H + T L A +VEV LL D GA + +S L
Sbjct: 372 GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 431
Query: 245 DLAAPKSSVEQALLLRE 261
LAA VE A LL E
Sbjct: 432 TLAACGGHVELAALLIE 448
Score = 75.1 bits (183), Expect = 7e-14
Identities = 54/167 (32%), Positives = 78/167 (46%), Gaps = 3/167 (1%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
SPL AA G + LI +G N+ V + L EA GH LL GA++N
Sbjct: 429 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 488
Query: 106 VTVHGA-TPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLAN 164
T T L ACC G + + L++ GA +E+ ++P+ EA + GH E ++ LLA+
Sbjct: 489 QTEETQETALTLACCGGFSEVADFLIKAGA--DIELGCSTPLMEASQEGHLELVKYLLAS 546
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPL 211
N+ T L AC D LL+ GA +D + + T L
Sbjct: 547 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTIL 593
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 95.9 bits (237), Expect = 4e-20
Identities = 72/223 (32%), Positives = 109/223 (48%), Gaps = 4/223 (1%)
Query: 44 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHV 103
D +PL A++ G L +K L+ +VN + ++L AC GG V K LL GA++
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
Query: 104 NGVTVHGATPLFNACCSGSAACVNVLLEFGA--KAQLEVHLASPIHEAVKRGHRECMEIL 161
+G TPL A +G VLL+ GA S + A +GH + + L
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391
Query: 162 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQSNV 220
L + +H+ ++ T L AC V+ + LL+ GA V+ ++PL AA +V
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQ-ALLLREG 262
E+ LL + GANL+ N +G + L AA + E ALLL +G
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQG 494
Score = 92.0 bits (227), Expect = 6e-19
Identities = 70/221 (31%), Positives = 112/221 (50%), Gaps = 7/221 (3%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
S L A +G L ++ L+ G + T ++L EAC+ GHV A+ LL++GA VN
Sbjct: 374 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA--SPIHEAVKRGHRECMEILLA 163
+PL A C G +L+E GA + EV+ +P+ EA + GH E + +LLA
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIERGANLE-EVNDEGYTPLMEAAREGHEEMVALLLA 492
Query: 164 NNVNIDHEVPQLG-TPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEV 222
NI+ + + T L +AC + L++ GA ++ G TPL A+++ ++E+
Sbjct: 493 QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG--CSTPLMEASQEGHLEL 550
Query: 223 IHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQA-LLLREG 262
+ L GAN+ A G +AL A + A +LL+ G
Sbjct: 551 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
Score = 89.0 bits (219), Expect = 5e-18
Identities = 64/195 (32%), Positives = 92/195 (47%), Gaps = 4/195 (2%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
SPL AA G + LI +G N+ V + L EA GH LL GA++N
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
Query: 106 VTVH-GATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLAN 164
T T L ACC G + + L++ G A +E+ ++P+ EA + GH E ++ LLA+
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAG--ADIELGCSTPLMEASQEGHLELVKYLLAS 557
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVI 223
N+ T L AC D LL+ GA ++H + TPL AAR ++ +
Sbjct: 558 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTV 617
Query: 224 HLLTDYGANLKRRNA 238
L GAN+ R A
Sbjct: 618 QFLISKGANVNRATA 632
Score = 81.3 bits (199), Expect = 1e-15
Identities = 62/186 (33%), Positives = 92/186 (49%), Gaps = 4/186 (2%)
Query: 80 SLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE 139
SL EAC G V + LL+ G VN T G + L AC +G VLL A +
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
Query: 140 VHLA--SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLEL 197
+ +P+ A G+ + +++LL ++ +++ + T L AC VD VK LL
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
Query: 198 GASV-DHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGK-SALDLAAPKSSVEQ 255
GA++ DH + TPL AA +VEV +L D+GA + + + K SAL LA K ++
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387
Query: 256 ALLLRE 261
L E
Sbjct: 388 VRFLLE 393
Score = 80.1 bits (196), Expect = 2e-15
Identities = 64/210 (30%), Positives = 101/210 (48%), Gaps = 7/210 (3%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PL A + GR + L+A+G N ++ + L A GG+V K LL GA +N
Sbjct: 1124 TPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS 1183
Query: 106 VTVH--GATPLFNACCSGSAACVNVLLEFGA--KAQLEVHLASPIHEAVKRGHRECMEIL 161
T G +PL A +G V +LL+ G+ AQ+E + + + A +G E + +L
Sbjct: 1184 RTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLL 1243
Query: 162 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH---GQWLDTPLHAAARQS 218
L N++H TPL A + + + LL+ GA V+ DT L AA +
Sbjct: 1244 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1303
Query: 219 NVEVIHLLTDYGANLKRRNAQGKSALDLAA 248
+ + LL GA++ RN +G + L LA+
Sbjct: 1304 HYKFCELLIHRGAHIDVRNKKGNTPLWLAS 1333
Score = 76.6 bits (187), Expect = 2e-14
Identities = 80/257 (31%), Positives = 106/257 (41%), Gaps = 41/257 (15%)
Query: 44 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEAC------------------ 85
D L EA + G + A++ L+ +G +VN T S L AC
Sbjct: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264
Query: 86 ----------------LGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVL 129
GG++ K LL + A VN + G T L AC G V VL
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 130 LEFGAKAQLEVHLA---SPIHEAVKRGHRECMEILLANNVNID-HEVPQLGTPLYVACTY 185
L G A +E H +P+ EA GH E +LL + I+ H + L +AC
Sbjct: 325 LNEG--ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 382
Query: 186 QRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSAL 244
+D V+ LLE GA +H + T L A +VEV LL D GA + +S L
Sbjct: 383 GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 442
Query: 245 DLAAPKSSVEQALLLRE 261
LAA VE A LL E
Sbjct: 443 TLAACGGHVELAALLIE 459
Score = 76.3 bits (186), Expect = 3e-14
Identities = 60/186 (32%), Positives = 89/186 (47%), Gaps = 5/186 (2%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNL-VTINRVSSLHEACLGGHVACAKALLENGAHVN 104
SPL AA G + A+K L+ G ++N + NR ++L AC G LL+ A+V
Sbjct: 1192 SPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVE 1251
Query: 105 GVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLAS---PIHEAVKRGHRECMEIL 161
G TPL A G A VLL+ GA +S + A +GH + E+L
Sbjct: 1252 HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1311
Query: 162 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNV 220
+ +ID + TPL++A D V+ L++ GA VD TPL +A R+ +V
Sbjct: 1312 IHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHV 1371
Query: 221 EVIHLL 226
+V+ L
Sbjct: 1372 KVVQYL 1377
Score = 73.6 bits (179), Expect = 2e-13
Identities = 59/190 (31%), Positives = 89/190 (46%), Gaps = 6/190 (3%)
Query: 76 NRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGA- 134
N ++L AC GGH L+ A + G TPL A +G V +LL+ G
Sbjct: 1054 NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD 1113
Query: 135 -KAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKK 193
+AQ E +P+ A G +E +++LLA N +H TPL +A + V+ +K
Sbjct: 1114 IEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1173
Query: 194 LLELGASVDH--GQWLD-TPLHAAARQSNVEVIHLLTDYGANLKRR-NAQGKSALDLAAP 249
LL GA ++ G L +PL AA +V + LL D G+++ + +AL LA
Sbjct: 1174 LLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACF 1233
Query: 250 KSSVEQALLL 259
+ E LL
Sbjct: 1234 QGRAEVVSLL 1243
Score = 67.4 bits (163), Expect = 1e-11
Identities = 71/262 (27%), Positives = 121/262 (46%), Gaps = 17/262 (6%)
Query: 43 ADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINR--VSSLHEACLGGHVACAKALLENG 100
+D +PL AA+ G + +K L+ G +N T ++ +S L A + GHV K LL+ G
Sbjct: 1154 SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG 1213
Query: 101 AHVNG-VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECM 158
+ +N + + T L AC G A V++LL+ A + +P+ EA G+ E
Sbjct: 1214 SDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVG 1273
Query: 159 EILLANNVNIDHE-VPQL-GTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAA 215
+LL +++ VP T L +A + L+ GA +D + +TPL A+
Sbjct: 1274 RVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLAS 1333
Query: 216 RQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQA-LLLREGPPALSQLCRLCV 274
+ +V+ LL GA++ + + + L A K V+ L++E S + C+
Sbjct: 1334 NGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDI--ECM 1391
Query: 275 R-------KCLGRACHQAIHKL 289
R K L + CHQ + +
Sbjct: 1392 RYIATITDKELLKKCHQCVETI 1413
Score = 65.9 bits (159), Expect = 4e-11
Identities = 49/155 (31%), Positives = 70/155 (45%), Gaps = 6/155 (3%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PL EA+ +G L +K L+A G NV+ T ++L AC GH A LL+ GA +
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVK----RGHRECMEIL 161
+ G TPL A +G V L+ GA A+ H V GH +E+L
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRAT--ANNDHTVVSLACAGGHLAVVELL 654
Query: 162 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLE 196
LA+ + H + T L A + V LL+
Sbjct: 655 LAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
Score = 54.7 bits (130), Expect = 1e-07
Identities = 33/89 (37%), Positives = 48/89 (53%), Gaps = 1/89 (1%)
Query: 45 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHE-ACLGGHVACAKALLENGAHV 103
R+PL +AA G L ++ LI++G NVN T N ++ AC GGH+A + LL +GA
Sbjct: 602 RTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADP 661
Query: 104 NGVTVHGATPLFNACCSGSAACVNVLLEF 132
G+T L A G V+ LL++
Sbjct: 662 THRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 33.1 bits (74), Expect = 0.31
Identities = 26/116 (22%), Positives = 53/116 (45%), Gaps = 4/116 (3%)
Query: 51 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHG 110
AA +G + LI +G ++++ + L A GGH + L++ GA V+
Sbjct: 1299 AADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRK 1358
Query: 111 ATPLFNACCSGSAACVNVLL----EFGAKAQLEVHLASPIHEAVKRGHRECMEILL 162
TPL +A G V L+ +F + + ++A+ + + + +C+E ++
Sbjct: 1359 ITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQCVETIV 1414
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 95.9 bits (237), Expect = 4e-20
Identities = 72/223 (32%), Positives = 109/223 (48%), Gaps = 4/223 (1%)
Query: 44 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHV 103
D +PL A++ G L +K L+ +VN + ++L AC GG V K LL GA++
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
Query: 104 NGVTVHGATPLFNACCSGSAACVNVLLEFGA--KAQLEVHLASPIHEAVKRGHRECMEIL 161
+G TPL A +G VLL+ GA S + A +GH + + L
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391
Query: 162 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQSNV 220
L + +H+ ++ T L AC V+ + LL+ GA V+ ++PL AA +V
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQ-ALLLREG 262
E+ LL + GANL+ N +G + L AA + E ALLL +G
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQG 494
Score = 92.0 bits (227), Expect = 6e-19
Identities = 70/221 (31%), Positives = 112/221 (50%), Gaps = 7/221 (3%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
S L A +G L ++ L+ G + T ++L EAC+ GHV A+ LL++GA VN
Sbjct: 374 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA--SPIHEAVKRGHRECMEILLA 163
+PL A C G +L+E GA + EV+ +P+ EA + GH E + +LLA
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIERGANLE-EVNDEGYTPLMEAAREGHEEMVALLLA 492
Query: 164 NNVNIDHEVPQLG-TPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEV 222
NI+ + + T L +AC + L++ GA ++ G TPL A+++ ++E+
Sbjct: 493 QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG--CSTPLMEASQEGHLEL 550
Query: 223 IHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQA-LLLREG 262
+ L GAN+ A G +AL A + A +LL+ G
Sbjct: 551 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
Score = 89.0 bits (219), Expect = 5e-18
Identities = 64/195 (32%), Positives = 92/195 (47%), Gaps = 4/195 (2%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
SPL AA G + LI +G N+ V + L EA GH LL GA++N
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
Query: 106 VTVH-GATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLAN 164
T T L ACC G + + L++ G A +E+ ++P+ EA + GH E ++ LLA+
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAG--ADIELGCSTPLMEASQEGHLELVKYLLAS 557
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVI 223
N+ T L AC D LL+ GA ++H + TPL AAR ++ +
Sbjct: 558 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTV 617
Query: 224 HLLTDYGANLKRRNA 238
L GAN+ R A
Sbjct: 618 QFLISKGANVNRATA 632
Score = 81.3 bits (199), Expect = 1e-15
Identities = 62/186 (33%), Positives = 92/186 (49%), Gaps = 4/186 (2%)
Query: 80 SLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE 139
SL EAC G V + LL+ G VN T G + L AC +G VLL A +
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
Query: 140 VHLA--SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLEL 197
+ +P+ A G+ + +++LL ++ +++ + T L AC VD VK LL
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
Query: 198 GASV-DHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGK-SALDLAAPKSSVEQ 255
GA++ DH + TPL AA +VEV +L D+GA + + + K SAL LA K ++
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387
Query: 256 ALLLRE 261
L E
Sbjct: 388 VRFLLE 393
Score = 80.1 bits (196), Expect = 2e-15
Identities = 64/210 (30%), Positives = 101/210 (48%), Gaps = 7/210 (3%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PL A + GR + L+A+G N ++ + L A GG+V K LL GA +N
Sbjct: 1124 TPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS 1183
Query: 106 VTVH--GATPLFNACCSGSAACVNVLLEFGA--KAQLEVHLASPIHEAVKRGHRECMEIL 161
T G +PL A +G V +LL+ G+ AQ+E + + + A +G E + +L
Sbjct: 1184 RTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLL 1243
Query: 162 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH---GQWLDTPLHAAARQS 218
L N++H TPL A + + + LL+ GA V+ DT L AA +
Sbjct: 1244 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1303
Query: 219 NVEVIHLLTDYGANLKRRNAQGKSALDLAA 248
+ + LL GA++ RN +G + L LA+
Sbjct: 1304 HYKFCELLIHRGAHIDVRNKKGNTPLWLAS 1333
Score = 76.6 bits (187), Expect = 2e-14
Identities = 80/257 (31%), Positives = 106/257 (41%), Gaps = 41/257 (15%)
Query: 44 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEAC------------------ 85
D L EA + G + A++ L+ +G +VN T S L AC
Sbjct: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264
Query: 86 ----------------LGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVL 129
GG++ K LL + A VN + G T L AC G V VL
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 130 LEFGAKAQLEVHLA---SPIHEAVKRGHRECMEILLANNVNID-HEVPQLGTPLYVACTY 185
L G A +E H +P+ EA GH E +LL + I+ H + L +AC
Sbjct: 325 LNEG--ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 382
Query: 186 QRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSAL 244
+D V+ LLE GA +H + T L A +VEV LL D GA + +S L
Sbjct: 383 GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 442
Query: 245 DLAAPKSSVEQALLLRE 261
LAA VE A LL E
Sbjct: 443 TLAACGGHVELAALLIE 459
Score = 76.3 bits (186), Expect = 3e-14
Identities = 60/186 (32%), Positives = 89/186 (47%), Gaps = 5/186 (2%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNL-VTINRVSSLHEACLGGHVACAKALLENGAHVN 104
SPL AA G + A+K L+ G ++N + NR ++L AC G LL+ A+V
Sbjct: 1192 SPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVE 1251
Query: 105 GVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLAS---PIHEAVKRGHRECMEIL 161
G TPL A G A VLL+ GA +S + A +GH + E+L
Sbjct: 1252 HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1311
Query: 162 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNV 220
+ +ID + TPL++A D V+ L++ GA VD TPL +A R+ +V
Sbjct: 1312 IHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHV 1371
Query: 221 EVIHLL 226
+V+ L
Sbjct: 1372 KVVQYL 1377
Score = 73.6 bits (179), Expect = 2e-13
Identities = 59/190 (31%), Positives = 89/190 (46%), Gaps = 6/190 (3%)
Query: 76 NRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGA- 134
N ++L AC GGH L+ A + G TPL A +G V +LL+ G
Sbjct: 1054 NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD 1113
Query: 135 -KAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKK 193
+AQ E +P+ A G +E +++LLA N +H TPL +A + V+ +K
Sbjct: 1114 IEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1173
Query: 194 LLELGASVDH--GQWLD-TPLHAAARQSNVEVIHLLTDYGANLKRR-NAQGKSALDLAAP 249
LL GA ++ G L +PL AA +V + LL D G+++ + +AL LA
Sbjct: 1174 LLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACF 1233
Query: 250 KSSVEQALLL 259
+ E LL
Sbjct: 1234 QGRAEVVSLL 1243
Score = 67.4 bits (163), Expect = 1e-11
Identities = 71/262 (27%), Positives = 121/262 (46%), Gaps = 17/262 (6%)
Query: 43 ADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINR--VSSLHEACLGGHVACAKALLENG 100
+D +PL AA+ G + +K L+ G +N T ++ +S L A + GHV K LL+ G
Sbjct: 1154 SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG 1213
Query: 101 AHVNG-VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECM 158
+ +N + + T L AC G A V++LL+ A + +P+ EA G+ E
Sbjct: 1214 SDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVG 1273
Query: 159 EILLANNVNIDHE-VPQL-GTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAA 215
+LL +++ VP T L +A + L+ GA +D + +TPL A+
Sbjct: 1274 RVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLAS 1333
Query: 216 RQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQA-LLLREGPPALSQLCRLCV 274
+ +V+ LL GA++ + + + L A K V+ L++E S + C+
Sbjct: 1334 NGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDI--ECM 1391
Query: 275 R-------KCLGRACHQAIHKL 289
R K L + CHQ + +
Sbjct: 1392 RYIATITDKELLKKCHQCVETI 1413
Score = 65.9 bits (159), Expect = 4e-11
Identities = 49/155 (31%), Positives = 70/155 (45%), Gaps = 6/155 (3%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PL EA+ +G L +K L+A G NV+ T ++L AC GH A LL+ GA +
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVK----RGHRECMEIL 161
+ G TPL A +G V L+ GA A+ H V GH +E+L
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRAT--ANNDHTVVSLACAGGHLAVVELL 654
Query: 162 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLE 196
LA+ + H + T L A + V LL+
Sbjct: 655 LAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
Score = 54.7 bits (130), Expect = 1e-07
Identities = 33/89 (37%), Positives = 48/89 (53%), Gaps = 1/89 (1%)
Query: 45 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHE-ACLGGHVACAKALLENGAHV 103
R+PL +AA G L ++ LI++G NVN T N ++ AC GGH+A + LL +GA
Sbjct: 602 RTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADP 661
Query: 104 NGVTVHGATPLFNACCSGSAACVNVLLEF 132
G+T L A G V+ LL++
Sbjct: 662 THRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 33.1 bits (74), Expect = 0.31
Identities = 26/116 (22%), Positives = 53/116 (45%), Gaps = 4/116 (3%)
Query: 51 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHG 110
AA +G + LI +G ++++ + L A GGH + L++ GA V+
Sbjct: 1299 AADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRK 1358
Query: 111 ATPLFNACCSGSAACVNVLL----EFGAKAQLEVHLASPIHEAVKRGHRECMEILL 162
TPL +A G V L+ +F + + ++A+ + + + +C+E ++
Sbjct: 1359 ITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQCVETIV 1414
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 94.7 bits (234), Expect = 9e-20
Identities = 64/208 (30%), Positives = 102/208 (49%), Gaps = 3/208 (1%)
Query: 44 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHV 103
DR +H AA G + +K L++ G V + LH A G ++ K LL+ G +
Sbjct: 173 DRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDM 232
Query: 104 NGVTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRE-CMEIL 161
N +G TPL AC +G VN L++ GA Q +P+H A H C+E+L
Sbjct: 233 NEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELL 292
Query: 162 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQSNV 220
+ N +++ + TPL++ + R + +++ GA +D + +TPLH AAR +
Sbjct: 293 VGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHE 352
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAA 248
+I+ L GA+ +R G L LAA
Sbjct: 353 LLINTLITSGADTAKRGIHGMFPLHLAA 380
Score = 85.1 bits (209), Expect = 7e-17
Identities = 67/216 (31%), Positives = 105/216 (48%), Gaps = 4/216 (1%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A A A++ L+ +VN N + LH A V CA+AL+ ++VN
Sbjct: 76 TPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNV 135
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQ-LEVHLASPIHEAVKRGHRECMEILLAN 164
G T L +A SG V +LL GA + IH A GH E +++L+++
Sbjct: 136 SDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSH 195
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVI 223
+ + + TPL+ A + + VK LL+LG ++ + +TPLH A V+
Sbjct: 196 GAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVV 255
Query: 224 HLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 259
+ L D GA + ++N +G + L AA +S AL L
Sbjct: 256 NELIDCGAIVNQKNEKGFTPLHFAA--ASTHGALCL 289
Score = 80.5 bits (197), Expect = 2e-15
Identities = 72/259 (27%), Positives = 105/259 (40%), Gaps = 45/259 (17%)
Query: 45 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTI---NRVSSLHEACLGGHVACAKALLENGA 101
R+P+H AA G L+ LI N V I N + L + L GH C +LL GA
Sbjct: 618 RTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGA 677
Query: 102 HVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE-------VHLA----------- 143
+V+ G T L +G CV+ LL+ GAK L +HL+
Sbjct: 678 NVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGA 737
Query: 144 --------------------SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVAC 183
+ +H A GH C+E+LL V +PL+ A
Sbjct: 738 LLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV-FQKTEGNAFSPLHCAV 796
Query: 184 TYQRVDCVKKLLE-LGASVDHGQWLD--TPLHAAARQSNVEVIHLLTDYGANLKRRNAQG 240
+ L++ LGAS+ + TPLHAAA +VE + LL + A + ++ G
Sbjct: 797 INDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTG 856
Query: 241 KSALDLAAPKSSVEQALLL 259
K+ L +AA +L
Sbjct: 857 KTPLMMAAENGQTNTVEML 875
Score = 79.7 bits (195), Expect = 3e-15
Identities = 58/205 (28%), Positives = 92/205 (44%), Gaps = 2/205 (0%)
Query: 45 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVN 104
R+PLH AA G ++ LI G VN ++ LH A + LL++ A VN
Sbjct: 42 RTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVN 101
Query: 105 GVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLA 163
+ TPL A + + C L+ + + + +H A GH E +++LL+
Sbjct: 102 ARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLS 161
Query: 164 NNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQSNVEV 222
NI+ + ++ A ++ VK L+ GA V + TPLHAAA + V
Sbjct: 162 RGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISV 221
Query: 223 IHLLTDYGANLKRRNAQGKSALDLA 247
+ L D G ++ NA G + L +A
Sbjct: 222 VKYLLDLGVDMNEPNAYGNTPLHVA 246
Score = 76.3 bits (186), Expect = 3e-14
Identities = 60/207 (28%), Positives = 97/207 (46%), Gaps = 3/207 (1%)
Query: 45 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVN 104
++PLH AAA + + L+ NVN+ ++LH A GH K LL GA++N
Sbjct: 108 QTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANIN 167
Query: 105 GVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLA 163
+ A G V +L+ GA+ + + +P+H A G ++ LL
Sbjct: 168 AFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLD 227
Query: 164 NNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLH-AAARQSNVE 221
V+++ TPL+VAC + V +L++ GA V+ + TPLH AAA
Sbjct: 228 LGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGAL 287
Query: 222 VIHLLTDYGANLKRRNAQGKSALDLAA 248
+ LL GA++ ++ GK+ L + A
Sbjct: 288 CLELLVGNGADVNMKSKDGKTPLHMTA 314
Score = 72.8 bits (177), Expect = 4e-13
Identities = 60/207 (28%), Positives = 92/207 (44%), Gaps = 3/207 (1%)
Query: 45 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVN 104
++PLH A GR +T+I G ++ N + LH A GH L+ +GA
Sbjct: 307 KTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTA 366
Query: 105 GVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLA 163
+HG PL A SG + C LL G + +H A G+ EC+ +LL
Sbjct: 367 KRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLN 426
Query: 164 NNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASV-DHGQWLDTPLH-AAARQSNVE 221
+ + + +PL+ A C+ L+ GASV D + TPLH AA ++ +
Sbjct: 427 TGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGK 486
Query: 222 VIHLLTDYGANLKRRNAQGKSALDLAA 248
+ L AN R+ QG +A+ +A
Sbjct: 487 CLEYLLRNDANPGIRDKQGYNAVHYSA 513
Score = 71.6 bits (174), Expect = 8e-13
Identities = 71/270 (26%), Positives = 110/270 (40%), Gaps = 49/270 (18%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH AA G L + TLI G + I+ + LH A L G C + LL +G ++
Sbjct: 341 TPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDT 400
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLAN 164
G T L A G+ C+N+LL GA + SP+H A + +C+ L+ +
Sbjct: 401 PDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGS 460
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVD-CVKKLLELGA---------------SVDHGQWLD 208
+++ + TPL+ A T C++ LL A S +G L
Sbjct: 461 GASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLC 520
Query: 209 -------------------------------TPLHAAARQSNVEVIHLLTDYGANLKRRN 237
+PLH AA + + + +L +L RN
Sbjct: 521 LQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRN 580
Query: 238 AQGKSALDLAAPKSSVEQA-LLLREGPPAL 266
+ G++ LDLAA K VE +L+ +G L
Sbjct: 581 SSGRTPLDLAAFKGHVECVDVLINQGASIL 610
Score = 70.5 bits (171), Expect = 2e-12
Identities = 68/251 (27%), Positives = 102/251 (40%), Gaps = 57/251 (22%)
Query: 45 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVN 104
R+ LH AAA G L L L+ G + N S LH A + C AL+ +GA VN
Sbjct: 406 RTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVN 465
Query: 105 GVTVHGATPLFNACCSGS-AACVNVLLEFGAKAQLE-------VHLA------------- 143
+ G TPL A S + C+ LL A + VH +
Sbjct: 466 DLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIA 525
Query: 144 --------------------------SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGT 177
SP+H A GH + +E+L+ + +++D T
Sbjct: 526 SETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRT 585
Query: 178 PLYVACTYQRVDCVKKLLELGASVDHGQWL--DTPLHAAARQSNVEVIHLLTDYGANLKR 235
PL +A V+CV L+ GAS+ ++ TP+HAAA + E + LL
Sbjct: 586 PLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIG------- 638
Query: 236 RNAQGKSALDL 246
NA+ ++A+D+
Sbjct: 639 -NAEPQNAVDI 648
Score = 59.7 bits (143), Expect = 3e-09
Identities = 64/260 (24%), Positives = 101/260 (38%), Gaps = 46/260 (17%)
Query: 45 RSPLHEAAAQGRLLALKTLI--AQGVNVNLVTINR--VSSLHEACLGGHVACAKALLENG 100
R+P+H +AA G + L L+ A ++ N T + ++LH AC GH C + LLE
Sbjct: 720 RTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQE 779
Query: 101 AHVNGVTVHGATPLFNACCSGSAACVNVLLE-FGAKA--QLEVHLASPIHEAVKRGHREC 157
+ +PL A + + +L++ GA + +P+H A H EC
Sbjct: 780 VFQK-TEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVEC 838
Query: 158 MEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKL------------------LELGA 199
+++LL++N ++ TPL +A + + V+ L L L
Sbjct: 839 LQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLAC 898
Query: 200 SVDH--------------------GQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQ 239
S H L TPLH AAR V+ L GA++ +
Sbjct: 899 SKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDEN 958
Query: 240 GKSALDLAAPKSSVEQALLL 259
G + AP V L L
Sbjct: 959 GYTPALACAPNKDVADCLAL 978
Score = 31.2 bits (69), Expect = 1.2
Identities = 18/51 (35%), Positives = 27/51 (52%)
Query: 209 TPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 259
TPLHAAA + E+I LL GA + ++++ + L A S E +L
Sbjct: 43 TPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVL 93
>gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2
[Homo sapiens]
Length = 474
Score = 93.6 bits (231), Expect = 2e-19
Identities = 89/304 (29%), Positives = 121/304 (39%), Gaps = 51/304 (16%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH AA++G L+ L+ + + R ++LHEAC GH AC LL GA N
Sbjct: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAK--AQLEVHLASPIHEAVKRGHRECMEILLA 163
G PL G+ C +LL FGA+ + E +P+H A + GH E ++LL
Sbjct: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
Query: 164 NNVNIDHEVPQLGTPLYVAC-------------TYQRVDCVKKLLELGASVDHG-QWLDT 209
D + TPL AC T + + LL GA D Q
Sbjct: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
Query: 210 PLHAAARQSNVEVIHLL---------TDYGANLKRRNAQGKSALDLAAPKSSVEQALL-- 258
PLH A R+ + V+ LL DYG + A A LA V +ALL
Sbjct: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
Query: 259 -----------------------LREGPPALSQLCRLCVRKCLGRACHQAIHKLHLPEPL 295
L P +L L R +R L + QA+ +L LP L
Sbjct: 402 GAVRVWPGALPKKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRL 461
Query: 296 ERFL 299
R+L
Sbjct: 462 LRYL 465
Score = 53.1 bits (126), Expect = 3e-07
Identities = 44/127 (34%), Positives = 57/127 (44%), Gaps = 4/127 (3%)
Query: 139 EVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELG 198
E L +P+H A RGH E + +LL D P T L+ AC CV LL G
Sbjct: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAG 216
Query: 199 ASVD-HGQWLDTPLHAAARQSNVEVIHLLTDYGANLK-RRNAQGKSALDLAAPKSSVEQA 256
A + Q PLH +E LL +GA + R + ++ L +AA VE A
Sbjct: 217 ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 276
Query: 257 -LLLREG 262
LLLR G
Sbjct: 277 DLLLRRG 283
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 91.7 bits (226), Expect = 7e-19
Identities = 71/216 (32%), Positives = 102/216 (47%), Gaps = 6/216 (2%)
Query: 48 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVT 107
LH AA G + L + G N N+ + LH A G+ + AKAL E G +VN
Sbjct: 449 LHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKN 508
Query: 108 VHGATPLFNACCSGSAACVNVLLEFGA---KAQLEVHLASPIHEAVKRGHRECMEILLAN 164
G TPL A G V L E GA + H+A +H AV+R E ++ LL+
Sbjct: 509 REGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIA--LHLAVRRCQMEVIKTLLSQ 566
Query: 165 NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQSNVEVI 223
+D++ TPL+VAC + V L E ++D ++ TPLH AA ++V+
Sbjct: 567 GCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVV 626
Query: 224 HLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 259
L GA+++ GK+A DLA + A LL
Sbjct: 627 RYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLL 662
Score = 56.2 bits (134), Expect = 3e-08
Identities = 55/217 (25%), Positives = 93/217 (42%), Gaps = 2/217 (0%)
Query: 47 PLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGV 106
PL AA G + L+ LI +G +++ ++++ A GHV K L EN ++
Sbjct: 382 PLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVK 441
Query: 107 TVHGATPLFNACCSGSAACVNVLLEFGAKAQLE-VHLASPIHEAVKRGHRECMEILLANN 165
G L A G A +L FG+ ++ +P+H A G+ + L
Sbjct: 442 DKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAG 501
Query: 166 VNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSNVEVIH 224
N++ + + TPL A D V+ L E GA ++ + LH A R+ +EVI
Sbjct: 502 CNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIK 561
Query: 225 LLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 261
L G + ++ G + L +A ++ + L E
Sbjct: 562 TLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCE 598
Score = 53.5 bits (127), Expect = 2e-07
Identities = 38/150 (25%), Positives = 70/150 (46%), Gaps = 2/150 (1%)
Query: 103 VNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLAS-PIHEAVKRGHRECMEIL 161
VN HG PL A G+ + +L++ G++ ++ S ++ A + GH + ++ L
Sbjct: 372 VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFL 431
Query: 162 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD-HGQWLDTPLHAAARQSNV 220
N +D + L+VA Y D + L G++ + + +TPLH AA
Sbjct: 432 SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYY 491
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAAPK 250
V L + G N+ +N +G++ L A+ +
Sbjct: 492 SVAKALCEAGCNVNIKNREGETPLLTASAR 521
Score = 40.8 bits (94), Expect = 0.001
Identities = 34/127 (26%), Positives = 56/127 (44%), Gaps = 5/127 (3%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PL A+A+G ++ L G ++N + +LH A + K LL G V+
Sbjct: 513 TPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDY 572
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV---HLASPIHEAVKRGHRECMEILL 162
HG TPL AC G+ V L E A L++ + +P+H A G + + L
Sbjct: 573 QDRHGNTPLHVACKDGNMPIVVALCE--ANCNLDISNKYGRTPLHLAANNGILDVVRYLC 630
Query: 163 ANNVNID 169
+++
Sbjct: 631 LMGASVE 637
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 91.3 bits (225), Expect = 1e-18
Identities = 85/282 (30%), Positives = 111/282 (39%), Gaps = 57/282 (20%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH AA GR ++ L+ G NV + LH AC GH LL +GA N
Sbjct: 60 TPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNA 119
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE-------VHLASPIHEAVKRG----- 153
TPL A G VLL+ GA+ + + LA P +AV G
Sbjct: 120 RDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKD 179
Query: 154 ----------HRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGAS--- 200
+ M +L NVN + TPL++A Y RV V+ LL+ GA
Sbjct: 180 ELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHA 239
Query: 201 ------------------------VDHGQ-------WLDTPLHAAARQSNVEVIHLLTDY 229
V HG W TPLH AA ++ VEV LL Y
Sbjct: 240 KDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSY 299
Query: 230 GANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCR 271
GA+ N KSA+DL AP +++ L +L Q R
Sbjct: 300 GADPTLLNCHNKSAIDL-APTPQLKERLAYEFKGHSLLQAAR 340
Score = 79.7 bits (195), Expect = 3e-15
Identities = 71/281 (25%), Positives = 114/281 (40%), Gaps = 58/281 (20%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH AA R+ ++ L+ G +V+ + LH AC GH A+ L+++GA VN
Sbjct: 528 TPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV 587
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLA-- 163
+ TPL A G +LL+ GA + + + VK G + ++L
Sbjct: 588 ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDA 647
Query: 164 --------------------NNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASV-- 201
+NVN + TPL++A Y ++ + LL+ GA V
Sbjct: 648 ALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNA 707
Query: 202 -DHG-------------------------------QWLDTPLHAAARQSNVEVIHLLTDY 229
D G +W TPLH AA++ ++ LL +
Sbjct: 708 QDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAH 767
Query: 230 GANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLC 270
GA+ +N +G++ LDL + + ALL PP+ C
Sbjct: 768 GADPTLKNQEGQTPLDLVS--ADDVSALLTAAMPPSALPSC 806
Score = 76.3 bits (186), Expect = 3e-14
Identities = 55/170 (32%), Positives = 77/170 (45%), Gaps = 10/170 (5%)
Query: 85 CLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLL--EFGAKAQLEVHL 142
C GG ACA A E A LF AC +G V L+ E
Sbjct: 6 CAGGGAACASAAAE-------AVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRK 58
Query: 143 ASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD 202
++P+H A G ++ +E LL N N+ PL+ AC++ + V LL GA +
Sbjct: 59 STPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPN 118
Query: 203 -HGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKS 251
W TPLH AA + ++V +L +GA RN G++ALDLA P +
Sbjct: 119 ARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSA 168
Score = 70.5 bits (171), Expect = 2e-12
Identities = 71/278 (25%), Positives = 115/278 (41%), Gaps = 41/278 (14%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH A+ + ++ ++ VN + +SLH A GH+ + LL G N
Sbjct: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
Query: 106 VTVHGATP-----------LFNACCSGSAACVNVLLEFGAKA------------------ 136
+++ G T L G++ LLE AKA
Sbjct: 462 ISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLE-AAKAGDVETVKKLCTVQSVNCR 520
Query: 137 QLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLE 196
+E ++P+H A +E LL + ++ + PL+ AC+Y + + L++
Sbjct: 521 DIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVK 580
Query: 197 LGASVDHGQ-WLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQ 255
GA V+ W TPLH AA + E+ LL +GA+ ++N G + LDL + Q
Sbjct: 581 HGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQ 640
Query: 256 ALLLREGPPALSQLCRLCVRKCLGRACHQAIHKLHLPE 293
LL G AL + + CL R + KL P+
Sbjct: 641 DLL--RGDAALLDAAK---KGCLAR-----VKKLSSPD 668
Score = 69.3 bits (168), Expect = 4e-12
Identities = 69/246 (28%), Positives = 110/246 (44%), Gaps = 27/246 (10%)
Query: 39 GDCWADRSPLHEAAAQGRLLALKTLIA-QGVNVNLVTINRVSSLHEACLGGHVACAKALL 97
G+ ADR L EAA G + +K L Q VN + + + LH A V+ + LL
Sbjct: 488 GNSEADRQLL-EAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLL 546
Query: 98 ENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQL-EVHLASPIHEAVKRGHRE 156
++GA V+ G PL NAC G +L++ GA + ++ +P+HEA +G E
Sbjct: 547 QHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYE 606
Query: 157 CMEILLANNVNIDHEVPQLGTPLYVA-----------------CTYQRVDCVKKLLELGA 199
++LL + + + TPL + + C+ ++ +L +
Sbjct: 607 ICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKL-S 665
Query: 200 SVDHGQWLD------TPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSV 253
S D+ D TPLH AA +N+EV L +GA++ ++ G L AA V
Sbjct: 666 SPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHV 725
Query: 254 EQALLL 259
+ A LL
Sbjct: 726 DVAALL 731
Score = 63.9 bits (154), Expect = 2e-10
Identities = 70/256 (27%), Positives = 108/256 (42%), Gaps = 24/256 (9%)
Query: 4 LTGENEKNCEVSERIRRSGPWKEISFGDYI---CHTFQGDCWADRSPLHEAAAQGRLLAL 60
LTGE +K+ E+ E R K ++ + CH G +PLH AA R+ +
Sbjct: 172 LTGEYKKD-ELLESARSGNEEKMMALLTPLNVNCHASDG---RKSTPLHLAAGYNRVKIV 227
Query: 61 KTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCS 120
+ L+ G +V+ + LH AC GH + L+++GA VN + + TPL A
Sbjct: 228 QLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASK 287
Query: 121 GSAACVNVLLEFGA-KAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPL 179
++LL +GA L H S I A +E + +E G L
Sbjct: 288 NRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKE----------RLAYEFK--GHSL 335
Query: 180 YVACTYQRVDCVKKLLELG-ASVDHGQWLDTPLHAAARQ---SNVEVIHLLTDYGANLKR 235
A V +KK L L + H Q +T LH AA ++ LL GAN+
Sbjct: 336 LQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINE 395
Query: 236 RNAQGKSALDLAAPKS 251
+ + + L +A+ K+
Sbjct: 396 KTKEFLTPLHVASEKA 411
Score = 46.6 bits (109), Expect = 3e-05
Identities = 37/116 (31%), Positives = 49/116 (42%), Gaps = 4/116 (3%)
Query: 25 KEISFGDYI-CHTFQGDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHE 83
K++S D + C QG +PLH AA L + L+ G +VN + LH
Sbjct: 662 KKLSSPDNVNCRDTQG---RHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHN 718
Query: 84 ACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE 139
A GHV A L++ A VN TPL A G +LL GA L+
Sbjct: 719 AASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLK 774
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 90.5 bits (223), Expect = 2e-18
Identities = 65/212 (30%), Positives = 103/212 (48%), Gaps = 6/212 (2%)
Query: 45 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVN 104
++PLH AA G + +K L +QG ++ N + LH A G V + LL++GA +
Sbjct: 495 KTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPD 554
Query: 105 GVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEILLA 163
+ G PL A G +LL +GA +L H +P+H A +GH E + +L
Sbjct: 555 ALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAE 614
Query: 164 NNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGA---SVDHGQWLDTPLHAAARQSNV 220
++ N+ TPL++A + V LL+ GA + + W TPLH A ++S
Sbjct: 615 SHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW--TPLHLAVQRSTF 672
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSS 252
+ L ++ AN+ RN G + LAA K +
Sbjct: 673 LSVINLLEHHANVHARNKVGWTPAHLAALKGN 704
Score = 81.6 bits (200), Expect = 8e-16
Identities = 72/236 (30%), Positives = 108/236 (45%), Gaps = 10/236 (4%)
Query: 33 ICHTFQGDCW--ADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHV 90
+ H DC + +PL AA + L+A G + N V + + LH A G
Sbjct: 382 LAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDD 441
Query: 91 ACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQL-EVHLASPIHEA 149
A+ LL++GA V+ G TPL A + +L+ A L E +P+H A
Sbjct: 442 GTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVA 501
Query: 150 VKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDT 209
GH +++L + +D + L TPL++A +V ++ LL+ GA D LD
Sbjct: 502 AYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDA---LDQ 558
Query: 210 ----PLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 261
PLH AA + + +L YGA+L+ QG + L LAA K +E LL E
Sbjct: 559 SGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAE 614
Score = 70.1 bits (170), Expect = 2e-12
Identities = 58/183 (31%), Positives = 88/183 (48%), Gaps = 4/183 (2%)
Query: 47 PLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGV 106
PLH AAA+G+ L K L+ G ++ L T + LH A GH+ L E+ A++ +
Sbjct: 563 PLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGAL 622
Query: 107 TVHGATPLFNACCSGSAACVNVLLEFGAKAQ-LEVHLASPIHEAVKRGHRECMEILLANN 165
TPL A G A V+ LL+ GA E +P+H AV+R + LL ++
Sbjct: 623 GAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHH 682
Query: 166 VNIDHEVPQLG-TPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVI 223
N+ H ++G TP ++A +K L+E GA +D + TPL A R ++
Sbjct: 683 ANV-HARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIM 741
Query: 224 HLL 226
L
Sbjct: 742 SFL 744
Score = 62.8 bits (151), Expect = 4e-10
Identities = 58/198 (29%), Positives = 89/198 (44%), Gaps = 5/198 (2%)
Query: 76 NRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAK 135
N+V+ LH G V + LL + V+ T G TPL A +LL GA
Sbjct: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
Query: 136 A-QLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKL 194
A +++ +P+H A + G +LL + +D + + TPL++A + + L
Sbjct: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
Query: 195 LELGASVD-HGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSV 253
+ A + H TPLH AA +V ++ LLT GA L + ++ L LA + V
Sbjct: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540
Query: 254 EQAL-LLREG--PPALSQ 268
LL+ G P AL Q
Sbjct: 541 RAIQHLLKSGAVPDALDQ 558
Score = 40.8 bits (94), Expect = 0.001
Identities = 32/117 (27%), Positives = 54/117 (46%), Gaps = 1/117 (0%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH AA G + L+ G + N + + LH A LLE+ A+V+
Sbjct: 628 TPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHA 687
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECMEIL 161
G TP A G+ A + VL+E GA+ ++ ++ +P+ A++ + M L
Sbjct: 688 RNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 89.7 bits (221), Expect = 3e-18
Identities = 75/238 (31%), Positives = 108/238 (45%), Gaps = 17/238 (7%)
Query: 27 ISFGDYICHTFQGDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACL 86
I G I HT Q D W + L AA G + L+ GV V+ + ++L A
Sbjct: 598 IGCGANINHTDQ-DGW---TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAW 653
Query: 87 GGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE------V 140
GGH LL++GA VN G T L A G V LL+ GA+ E
Sbjct: 654 GGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTA 713
Query: 141 HLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGAS 200
+ + +GH + +L+ +DH TPL VA VD V LLE GA
Sbjct: 714 LSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGAD 773
Query: 201 VDH----GQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVE 254
VDH G+ TPL AAA + V++ L +GA + +++G++ L +A+ + +VE
Sbjct: 774 VDHTDNNGR---TPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVE 828
Score = 82.8 bits (203), Expect = 3e-16
Identities = 62/228 (27%), Positives = 108/228 (47%), Gaps = 2/228 (0%)
Query: 45 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVN 104
R+ L A+AQG + ++TL+ +G++ N + LH A GH +AL+E GA N
Sbjct: 815 RTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTN 874
Query: 105 GVTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEILLA 163
+ G P A G CV +LLE + Q + + A GHR+ +E+L +
Sbjct: 875 EIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFS 934
Query: 164 NNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEV 222
+ +++ + LY+ ++ + LE GA+V+ T LH + Q ++E+
Sbjct: 935 HGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEM 994
Query: 223 IHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLC 270
+ +L Y A++ + + +SAL AA + V+ LL E + C
Sbjct: 995 VQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTC 1042
Score = 82.8 bits (203), Expect = 3e-16
Identities = 56/190 (29%), Positives = 92/190 (48%), Gaps = 2/190 (1%)
Query: 45 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVN 104
R+ L AA +G ++ L + G +VN + +L+ L + A+ LENGA+V
Sbjct: 914 RNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVE 973
Query: 105 GVTVHGATPLFNACCSGSAACVNVLLEFGAKAQ-LEVHLASPIHEAVKRGHRECMEILLA 163
G T L +C G V VL+ + A + S + A +GH + +++L+
Sbjct: 974 ASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIE 1033
Query: 164 NNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHG-QWLDTPLHAAARQSNVEV 222
+ +DH Q T L +A +D V+ LLE GA +H Q+ T + AA+ + ++
Sbjct: 1034 HGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQI 1093
Query: 223 IHLLTDYGAN 232
I LL YGA+
Sbjct: 1094 IKLLEKYGAS 1103
Score = 74.7 bits (182), Expect = 9e-14
Identities = 61/217 (28%), Positives = 99/217 (45%), Gaps = 2/217 (0%)
Query: 45 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVN 104
R+PL AA+ G + TL+ G V+ + + L A G+V + LL+ G N
Sbjct: 782 RTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDEN 841
Query: 105 GVTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEILLA 163
G TPL A G L+E GA+ +++ P A + GH +C++ILL
Sbjct: 842 HRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLE 901
Query: 164 NNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTP-LHAAARQSNVEV 222
N NID L VA D V+ L GA V+ P L+ A ++ + +
Sbjct: 902 NKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTM 961
Query: 223 IHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 259
+ GAN++ +A+G++AL ++ + +E +L
Sbjct: 962 AEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL 998
Score = 69.7 bits (169), Expect = 3e-12
Identities = 61/207 (29%), Positives = 88/207 (42%), Gaps = 2/207 (0%)
Query: 44 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHV 103
DR+ A R +++TL+ G +VN N + L A G + L+ GA +
Sbjct: 512 DRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADL 571
Query: 104 NGVTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGHRECMEILL 162
HG TPL A G VN L+ GA + + + A GH E + LL
Sbjct: 572 EIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALL 631
Query: 163 ANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVE 221
V +D T L A D V LL+ GA V+ T L AAA + E
Sbjct: 632 YAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHRE 691
Query: 222 VIHLLTDYGANLKRRNAQGKSALDLAA 248
++ L D+GA + + G++AL +AA
Sbjct: 692 IVEHLLDHGAEVNHEDVDGRTALSVAA 718
Score = 69.7 bits (169), Expect = 3e-12
Identities = 63/240 (26%), Positives = 100/240 (41%), Gaps = 35/240 (14%)
Query: 52 AAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGA 111
A++G + LI +G V+ + ++ L A GHV LLE GA V+ +G
Sbjct: 723 ASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGR 782
Query: 112 TPLFNACCSGSAACVNVLLEFG----------------AKAQLEVHLA------------ 143
TPL A G A+ VN LL +G A AQ V +
Sbjct: 783 TPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENH 842
Query: 144 ------SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLEL 197
+P+H A GHR E L+ + P +A DCV+ LLE
Sbjct: 843 RDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLEN 902
Query: 198 GASVD-HGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQA 256
+++D G L AA + + +++ LL +GA++ ++A G+ L + A ++ + A
Sbjct: 903 KSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMA 962
Score = 50.4 bits (119), Expect = 2e-06
Identities = 40/161 (24%), Positives = 70/161 (43%), Gaps = 1/161 (0%)
Query: 45 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVN 104
R L+ A + +L + + G NV ++LH +C GH+ + L+ A VN
Sbjct: 947 RPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVN 1006
Query: 105 GVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHL-ASPIHEAVKRGHRECMEILLA 163
+ L +A G V +L+E GA + A+ + A + GH + +++LL
Sbjct: 1007 AADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLE 1066
Query: 164 NNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHG 204
+ + +H T + VA +K L + GAS +G
Sbjct: 1067 HGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNG 1107
Score = 45.4 bits (106), Expect = 6e-05
Identities = 32/103 (31%), Positives = 50/103 (48%), Gaps = 1/103 (0%)
Query: 45 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVN 104
RS L AA QG + ++ LI G V+ ++L A GH+ + LLE+GA N
Sbjct: 1013 RSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPN 1072
Query: 105 GVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIH 147
G T + A +G + + +L ++GA + L SP+H
Sbjct: 1073 HADQFGRTAMRVAAKNGHSQIIKLLEKYGA-SSLNGCSPSPVH 1114
>gi|38176283 ankyrin repeat and SOCS box-containing protein 7
isoform 2 [Homo sapiens]
Length = 318
Score = 89.4 bits (220), Expect = 4e-18
Identities = 74/267 (27%), Positives = 130/267 (48%), Gaps = 15/267 (5%)
Query: 48 LHEAAAQGRLLALKTLIAQGVNVNLVT-INRVSSLHEACLGGHVACAKALLENGAH---V 103
LH +AA+G+ ++ + G + + I ++LH A + G A+ +LE+ +
Sbjct: 51 LHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDII 110
Query: 104 NGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQ-LEVHLASPIHEAVKRGHRECMEILL 162
N + G TPL A G + V +LLEF A+ L +P+ A+ R C++ILL
Sbjct: 111 NAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILL 170
Query: 163 ANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSNV 220
+N NID Q G L A + L+ GA + G+ D TPLH +A + +V
Sbjct: 171 DHNANIDI---QNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDV 227
Query: 221 EVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALL-----LREGPPALSQLCRLCVR 275
+L +YGA+ RN +G++ L ++ S + L + P L LCR+ +R
Sbjct: 228 LCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQEVTRQPRNLQDLCRIKIR 287
Query: 276 KCLGRACHQAIHKLHLPEPLERFLLYQ 302
+C+G + + +L + + ++ +L ++
Sbjct: 288 QCIGLQNLKLLDELPIAKVMKDYLKHK 314
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 89.0 bits (219), Expect = 5e-18
Identities = 81/258 (31%), Positives = 104/258 (40%), Gaps = 56/258 (21%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
SPLH AA GR ++ L+ G NV+ + LH AC GH LL GA N
Sbjct: 218 SPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNA 277
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE-------VHLASP------------- 145
TPL A G VLL+ GA + + LA P
Sbjct: 278 RDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKD 337
Query: 146 -IHEAVKRGHRE-CMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASV-- 201
+ EA + G+ E M +L NVN + TPL++A Y RV V+ LL+ GA V
Sbjct: 338 ELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHA 397
Query: 202 -------------------------DHGQ-------WLDTPLHAAARQSNVEVIHLLTDY 229
HG W TPLH AA ++ VEV LL +
Sbjct: 398 KDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSH 457
Query: 230 GANLKRRNAQGKSALDLA 247
GA+ N GKSA+D+A
Sbjct: 458 GADPTLVNCHGKSAVDMA 475
Score = 83.2 bits (204), Expect = 3e-16
Identities = 72/281 (25%), Positives = 113/281 (40%), Gaps = 58/281 (20%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH AA R+ ++ L+ G +V+ + LH AC GH A+ L+ +GA VN
Sbjct: 686 TPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNV 745
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLAN- 164
+ TPL A G +LL+ GA + + + VK G + ++L +
Sbjct: 746 ADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDA 805
Query: 165 ---------------------NVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASV-- 201
N+N + TPL++A Y ++ + LLE GA V
Sbjct: 806 ALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNA 865
Query: 202 -DHG-------------------------------QWLDTPLHAAARQSNVEVIHLLTDY 229
D G +W TPLH AA++ ++ LL +
Sbjct: 866 QDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAH 925
Query: 230 GANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLC 270
GA+ +N +G++ LDLA +ALL+ PP C
Sbjct: 926 GADPTMKNQEGQTPLDLATADDI--RALLIDAMPPEALPTC 964
Score = 75.9 bits (185), Expect = 4e-14
Identities = 74/281 (26%), Positives = 117/281 (41%), Gaps = 47/281 (16%)
Query: 46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNG 105
+PLH AA + ++ L G +N + ++LH A L GH+ + LL G+ +
Sbjct: 560 TPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 619
Query: 106 VTVHGATPLFNACCSGSAACVNVLLEF--------------GAKA--------------- 136
+++ G F A G+ A +L E +KA
Sbjct: 620 ISLQG----FTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNV 675
Query: 137 ---QLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKK 193
LE ++P+H A +E LL + ++ + PL+ AC+Y + +
Sbjct: 676 NCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAEL 735
Query: 194 LLELGASVDHGQ-WLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSS 252
L+ GASV+ W TPLH AA + E+ LL +GA+ ++N G + LDL +
Sbjct: 736 LVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDT 795
Query: 253 VEQALLLREGPPALSQLCRLCVRKCLGRACHQAIHKLHLPE 293
Q LL G AL + + CL R + KL PE
Sbjct: 796 DIQDLL--RGDAALLDAAK---KGCLAR-----VQKLCTPE 826
Score = 68.6 bits (166), Expect = 7e-12
Identities = 78/286 (27%), Positives = 130/286 (45%), Gaps = 35/286 (12%)
Query: 4 LTGENEKNCEVSERIRRSGPWKEISFGDYI---CHTFQGDCWADRSPLHEAAAQGRLLAL 60
LTGE +K+ E+ E R K ++ + CH G +PLH AA R+ +
Sbjct: 330 LTGEYKKD-ELLEAARSGNEEKLMALLTPLNVNCHASDG---RKSTPLHLAAGYNRVRIV 385
Query: 61 KTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCS 120
+ L+ G +V+ + LH AC GH + LL++GA VN + + TPL A
Sbjct: 386 QLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASK 445
Query: 121 GSAACVNVLLEFGA---------KAQLEVHLASPIHEAVK---RGH------REC----M 158
++LL GA K+ +++ + E + +GH RE +
Sbjct: 446 NRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKV 505
Query: 159 EILLANNVNIDHEVPQL-GTPLYVACTY---QRVDCVKKLLELGASV-DHGQWLDTPLHA 213
+ LA + I+ + PQ T L+ A +R + LL GA+V + + TPLH
Sbjct: 506 KKTLALEI-INFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHV 564
Query: 214 AARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 259
AA +++ +V+ +L +GA + + G++AL AA ++ LL
Sbjct: 565 AAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLL 610
Score = 43.9 bits (102), Expect = 2e-04
Identities = 32/101 (31%), Positives = 41/101 (40%), Gaps = 3/101 (2%)
Query: 34 CHTFQGDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACA 93
C QG + +PLH AA L + L+ G +VN + LH A GHV A
Sbjct: 830 CRDTQG---RNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIA 886
Query: 94 KALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGA 134
L++ VN TPL A G +LL GA
Sbjct: 887 ALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGA 927
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,933,482
Number of Sequences: 37866
Number of extensions: 521317
Number of successful extensions: 4819
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 310
Number of HSP's successfully gapped in prelim test: 50
Number of HSP's that attempted gapping in prelim test: 991
Number of HSP's gapped (non-prelim): 1629
length of query: 302
length of database: 18,247,518
effective HSP length: 102
effective length of query: 200
effective length of database: 14,385,186
effective search space: 2877037200
effective search space used: 2877037200
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.