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Search of human proteins with 58331266
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|58331266 WD repeat domain 59 [Homo sapiens]
(974 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|58331266 WD repeat domain 59 [Homo sapiens] 2018 0.0
gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens] 73 1e-12
gi|14149987 WD repeat domain 24 [Homo sapiens] 73 1e-12
gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens] 72 2e-12
gi|207029439 retinoblastoma binding protein 4 isoform c [Homo sa... 72 3e-12
gi|207029415 retinoblastoma binding protein 4 isoform b [Homo sa... 72 3e-12
gi|5032027 retinoblastoma binding protein 4 isoform a [Homo sapi... 72 3e-12
gi|16554629 WD repeat domain 5 [Homo sapiens] 69 2e-11
gi|16554627 WD repeat domain 5 [Homo sapiens] 69 2e-11
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 67 1e-10
gi|23199987 WD repeat domain 5B [Homo sapiens] 66 2e-10
gi|4506439 retinoblastoma binding protein 7 [Homo sapiens] 65 2e-10
gi|14149696 SEC31 homolog B [Homo sapiens] 65 3e-10
gi|4507703 tumor suppressing subtransferable candidate 1 [Homo s... 64 5e-10
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 62 2e-09
gi|116256340 SEC31 homolog A isoform 3 [Homo sapiens] 61 4e-09
gi|116256338 SEC31 homolog A isoform 1 [Homo sapiens] 61 4e-09
gi|116256336 SEC31 homolog A isoform 4 [Homo sapiens] 61 4e-09
gi|41349441 SEC31 homolog A isoform 2 [Homo sapiens] 61 4e-09
gi|41349439 SEC31 homolog A isoform 1 [Homo sapiens] 61 4e-09
gi|62234438 Notchless gene homolog isoform b [Homo sapiens] 59 3e-08
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 59 3e-08
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 57 6e-08
gi|209969680 Fzr1 protein isoform 1 [Homo sapiens] 57 8e-08
gi|209969678 Fzr1 protein isoform 3 [Homo sapiens] 57 8e-08
gi|33620742 Fzr1 protein isoform 2 [Homo sapiens] 57 8e-08
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens] 57 1e-07
gi|32189425 WD repeat domain 69 [Homo sapiens] 55 2e-07
gi|4757988 WD repeat domain 39 [Homo sapiens] 55 3e-07
gi|19913367 transducin beta-like 1Y [Homo sapiens] 54 5e-07
>gi|58331266 WD repeat domain 59 [Homo sapiens]
Length = 974
Score = 2018 bits (5227), Expect = 0.0
Identities = 974/974 (100%), Positives = 974/974 (100%)
Query: 1 MAARWSSENVVVEFRDSQATAMSVDCLGQHAVLSGRRFLYIVNLDAPFEGHRKISRQSKW 60
MAARWSSENVVVEFRDSQATAMSVDCLGQHAVLSGRRFLYIVNLDAPFEGHRKISRQSKW
Sbjct: 1 MAARWSSENVVVEFRDSQATAMSVDCLGQHAVLSGRRFLYIVNLDAPFEGHRKISRQSKW 60
Query: 61 DIGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPDL 120
DIGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPDL
Sbjct: 61 DIGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPDL 120
Query: 121 LVTSSVDTYIYIWDIKDTRKPTVALSAVAGASQVKWNKKNANCLATSHDGDVRIWDKRKP 180
LVTSSVDTYIYIWDIKDTRKPTVALSAVAGASQVKWNKKNANCLATSHDGDVRIWDKRKP
Sbjct: 121 LVTSSVDTYIYIWDIKDTRKPTVALSAVAGASQVKWNKKNANCLATSHDGDVRIWDKRKP 180
Query: 181 STAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPCQVPVWKA 240
STAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPCQVPVWKA
Sbjct: 181 STAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPCQVPVWKA 240
Query: 241 RYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDY 300
RYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDY
Sbjct: 241 RYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDY 300
Query: 301 QLVTWSRDQTLRMWRVDSQMQRLCANDILDGVDEFIESISLLPEPEKTLHTEDTDHQHTA 360
QLVTWSRDQTLRMWRVDSQMQRLCANDILDGVDEFIESISLLPEPEKTLHTEDTDHQHTA
Sbjct: 301 QLVTWSRDQTLRMWRVDSQMQRLCANDILDGVDEFIESISLLPEPEKTLHTEDTDHQHTA 360
Query: 361 SHGEEEALKEDPPRNLLEERKSDQLGLPQTLQQEFSLINVQIRNVNVEMDAADRSCTVSV 420
SHGEEEALKEDPPRNLLEERKSDQLGLPQTLQQEFSLINVQIRNVNVEMDAADRSCTVSV
Sbjct: 361 SHGEEEALKEDPPRNLLEERKSDQLGLPQTLQQEFSLINVQIRNVNVEMDAADRSCTVSV 420
Query: 421 HCSNHRVKMLVKFPAQYPNNAAPSFQFINPTTITSTMKAKLLKILKDTALQKVKRGQSCL 480
HCSNHRVKMLVKFPAQYPNNAAPSFQFINPTTITSTMKAKLLKILKDTALQKVKRGQSCL
Sbjct: 421 HCSNHRVKMLVKFPAQYPNNAAPSFQFINPTTITSTMKAKLLKILKDTALQKVKRGQSCL 480
Query: 481 EPCLRQLVSCLESFVNQEDSASSNPFALPNSVTPPLPTFARVTTAYGSYQDANIPFPRTS 540
EPCLRQLVSCLESFVNQEDSASSNPFALPNSVTPPLPTFARVTTAYGSYQDANIPFPRTS
Sbjct: 481 EPCLRQLVSCLESFVNQEDSASSNPFALPNSVTPPLPTFARVTTAYGSYQDANIPFPRTS 540
Query: 541 GARFCGAGYLVYFTRPMTMHRAVSPTEPTPRSLSALSAYHTGLIAPMKIRTEAPGNLRLY 600
GARFCGAGYLVYFTRPMTMHRAVSPTEPTPRSLSALSAYHTGLIAPMKIRTEAPGNLRLY
Sbjct: 541 GARFCGAGYLVYFTRPMTMHRAVSPTEPTPRSLSALSAYHTGLIAPMKIRTEAPGNLRLY 600
Query: 601 SGSPTRSEKEQVSISSFYYKERKSRRWKSKREGSDSGNRQIKAAGKVIIQDIACLLPVHK 660
SGSPTRSEKEQVSISSFYYKERKSRRWKSKREGSDSGNRQIKAAGKVIIQDIACLLPVHK
Sbjct: 601 SGSPTRSEKEQVSISSFYYKERKSRRWKSKREGSDSGNRQIKAAGKVIIQDIACLLPVHK 660
Query: 661 SLGELYILNVNDIQETCQKNAASALLVGRKDLVQVWSLATVATDLCLGPKSDPDLETPWA 720
SLGELYILNVNDIQETCQKNAASALLVGRKDLVQVWSLATVATDLCLGPKSDPDLETPWA
Sbjct: 661 SLGELYILNVNDIQETCQKNAASALLVGRKDLVQVWSLATVATDLCLGPKSDPDLETPWA 720
Query: 721 RHPFGRQLLESLLAHYCRLRDVQTLAMLCSVFEAQSRPQGLPNPFGPFPNRSSNLVVSHS 780
RHPFGRQLLESLLAHYCRLRDVQTLAMLCSVFEAQSRPQGLPNPFGPFPNRSSNLVVSHS
Sbjct: 721 RHPFGRQLLESLLAHYCRLRDVQTLAMLCSVFEAQSRPQGLPNPFGPFPNRSSNLVVSHS 780
Query: 781 RYPSFTSSGSCSSMSDPGLNTGGWNIAGREAEHLSSPWGESSPEELRFGSLTYSDPRERE 840
RYPSFTSSGSCSSMSDPGLNTGGWNIAGREAEHLSSPWGESSPEELRFGSLTYSDPRERE
Sbjct: 781 RYPSFTSSGSCSSMSDPGLNTGGWNIAGREAEHLSSPWGESSPEELRFGSLTYSDPRERE 840
Query: 841 RDQHDKNKRLLDPANTQQFDDFKKCYGEILYRWGLREKRAEVLKFVSCPPDPHKGIEFGV 900
RDQHDKNKRLLDPANTQQFDDFKKCYGEILYRWGLREKRAEVLKFVSCPPDPHKGIEFGV
Sbjct: 841 RDQHDKNKRLLDPANTQQFDDFKKCYGEILYRWGLREKRAEVLKFVSCPPDPHKGIEFGV 900
Query: 901 YCSHCRSEVRGTQCAICKGFTFQCAICHVAVRGSSNFCLTCGHGGHTSHMMEWFRTQEVC 960
YCSHCRSEVRGTQCAICKGFTFQCAICHVAVRGSSNFCLTCGHGGHTSHMMEWFRTQEVC
Sbjct: 901 YCSHCRSEVRGTQCAICKGFTFQCAICHVAVRGSSNFCLTCGHGGHTSHMMEWFRTQEVC 960
Query: 961 PTGCGCHCLLESTF 974
PTGCGCHCLLESTF
Sbjct: 961 PTGCGCHCLLESTF 974
>gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]
Length = 446
Score = 73.2 bits (178), Expect = 1e-12
Identities = 36/124 (29%), Positives = 59/124 (47%), Gaps = 6/124 (4%)
Query: 103 GHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKP----TVALSAVAGASQVKWNK 158
GHTR + DL W+ E + + S D I IWDI+ T A + + + W++
Sbjct: 259 GHTRSVEDLQWSPTENTVFASCSADASIRIWDIRAAPSKACMLTTATAHDGDVNVISWSR 318
Query: 159 KNANCLATSHDGDVRIWDKR--KPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSV 216
+ L+ DG ++IWD R K + V H++ + ++WHP + A S D+ +
Sbjct: 319 REPFLLSGGDDGALKIWDLRQFKSGSPVATFKQHVAPVTSVEWHPQDSGVFAASGADHQI 378
Query: 217 KFWD 220
WD
Sbjct: 379 TQWD 382
Score = 41.2 bits (95), Expect = 0.005
Identities = 37/133 (27%), Positives = 52/133 (39%), Gaps = 28/133 (21%)
Query: 190 HLSKIHGLDWHPDSEHILATSSQDNSVKFWDYR-QPRKYLNILPCQVPVWKARYTPFSNG 248
H + L W P + A+ S D S++ WD R P K C + A +G
Sbjct: 260 HTRSVEDLQWSPTENTVFASCSADASIRIWDIRAAPSK-----ACMLTTATAH-----DG 309
Query: 249 LVTVMVPQLRRENSLL---------LWNV--FDLNTPVHTFVGHDDVVLEFQWRKQKEG- 296
V V + RRE LL +W++ F +PV TF H V +W Q G
Sbjct: 310 DVNV-ISWSRREPFLLSGGDDGALKIWDLRQFKSGSPVATFKQHVAPVTSVEWHPQDSGV 368
Query: 297 ----SKDYQLVTW 305
D+Q+ W
Sbjct: 369 FAASGADHQITQW 381
Score = 30.4 bits (67), Expect = 8.4
Identities = 18/82 (21%), Positives = 34/82 (41%), Gaps = 3/82 (3%)
Query: 61 DIGAVQWNPHDSFAHYFAASSNQRV-DLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPD 119
D+ + W+ + F ++ DL ++K GS T + H ++ ++W +
Sbjct: 310 DVNVISWSRREPFLLSGGDDGALKIWDLRQFKSGSPVA--TFKQHVAPVTSVEWHPQDSG 367
Query: 120 LLVTSSVDTYIYIWDIKDTRKP 141
+ S D I WD+ R P
Sbjct: 368 VFAASGADHQITQWDLAVERDP 389
>gi|14149987 WD repeat domain 24 [Homo sapiens]
Length = 790
Score = 72.8 bits (177), Expect = 1e-12
Identities = 42/128 (32%), Positives = 59/128 (46%), Gaps = 9/128 (7%)
Query: 848 KRLLDPANTQQFDDFKKCYGEILYRWGLREKRAEVLKF-----VSCPPDPHKGIEFGVYC 902
+R+ + Q + + Y ++L R+ L EV+K VSC + V C
Sbjct: 662 ERVRKDIDEQTQEHWYTSYIDLLQRFRLWNVSNEVVKLSTSRAVSCLNQASTTLH--VNC 719
Query: 903 SHCRSEV--RGTQCAICKGFTFQCAICHVAVRGSSNFCLTCGHGGHTSHMMEWFRTQEVC 960
SHC+ + RG C C CA+CH V+G +C C HGGH H+M+W C
Sbjct: 720 SHCKRPMSSRGWVCDRCHRCASMCAVCHHVVKGLFVWCQGCSHGGHLQHIMKWLEGSSHC 779
Query: 961 PTGCGCHC 968
P GCG C
Sbjct: 780 PAGCGHLC 787
Score = 70.5 bits (171), Expect = 7e-12
Identities = 73/305 (23%), Positives = 134/305 (43%), Gaps = 25/305 (8%)
Query: 16 DSQATAMSVDCLGQHAVLSGRRF--LYIVNLDAPFEG-HRKISRQSKWDIGA--VQWNPH 70
D+ A A+SV V++GR +Y + + E + ++ R+ ++ V W+
Sbjct: 26 DAPANAISVCRDAAQVVVAGRSIFKIYAIEEEQFVEKLNLRVGRKPSLNLSCADVVWHQM 85
Query: 71 DSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYI 130
D AA++ V + + H R ++ + + E +L++ S D ++
Sbjct: 86 DENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFM 145
Query: 131 YIWDIKDTRKPTVALSAVAGASQ----VKWNKKNANCLA-TSHDGDVRIWDKRKPSTAVE 185
+D++ RK +V S +G S+ V+++ ++ A T +G+V++WD R+P
Sbjct: 146 KCFDLR--RKDSV--STFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCER 201
Query: 186 YLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPR-KYLNILPCQVPVWKARYTP 244
AH + DWHP+ LAT +D VK WD R K ++ + V + ++ P
Sbjct: 202 MFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQTIASVARVKWRP 261
Query: 245 -FSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKE------GS 297
+ L T + ++++ +W+V P F H DV WR + GS
Sbjct: 262 ECRHHLATC---SMMVDHNIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGS 318
Query: 298 KDYQL 302
KD L
Sbjct: 319 KDSSL 323
>gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]
Length = 323
Score = 72.4 bits (176), Expect = 2e-12
Identities = 53/175 (30%), Positives = 84/175 (48%), Gaps = 12/175 (6%)
Query: 48 FEGHRKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRV 107
F GH I I + W+PH FA++S + L W + V + H
Sbjct: 151 FRGHESI-------IYSTIWSPH--IPGCFASASGDQT-LRIWDVKAAGVRIVIPAHQAE 200
Query: 108 ISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVAGA-SQVKWNKKNANCLAT 166
I DW + +LLVT +VD + WD+++ R+P L A +VK++ +A+ LA+
Sbjct: 201 ILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLAS 260
Query: 167 -SHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWD 220
S+D VR W+ KP + +E + H GLD+ S +A S D ++K +D
Sbjct: 261 CSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYD 315
Score = 67.4 bits (163), Expect = 6e-11
Identities = 48/180 (26%), Positives = 78/180 (43%), Gaps = 3/180 (1%)
Query: 50 GHRKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVIS 109
G ++ ++ ++ +V W+ + S +Q V L W G+ T +GH +I
Sbjct: 102 GPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKL--WDPTVGKSLCTFRGHESIIY 159
Query: 110 DLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVAGASQVKWNKKNANCLAT-SH 168
W+ P ++S D + IWD+K V + A W K N N L T +
Sbjct: 160 STIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTGAV 219
Query: 169 DGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRKYL 228
D +R WD R V L H I + + P +LA+ S D +V+FW++ +P L
Sbjct: 220 DCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLL 279
Score = 55.1 bits (131), Expect = 3e-07
Identities = 39/167 (23%), Positives = 70/167 (41%), Gaps = 11/167 (6%)
Query: 150 GASQVKWNKKNANCLAT-SHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDW-HPDSEHIL 207
G V W++ N + L T S DG +++WD K + ++ H +++ +DW E ++
Sbjct: 69 GLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLV 128
Query: 208 ATSSQDNSVKFWDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQLRRENSLLLWN 267
+ S D +VK WD + + ++ ++P G + +L +W+
Sbjct: 129 VSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFA----SASGDQTLRIWD 184
Query: 268 VFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDYQLVTWSRDQTLRMW 314
V + H +L W K E LVT + D +LR W
Sbjct: 185 VKAAGVRI-VIPAHQAEILSCDWCKYNEN----LLVTGAVDCSLRGW 226
Score = 50.4 bits (119), Expect = 8e-06
Identities = 48/209 (22%), Positives = 83/209 (39%), Gaps = 14/209 (6%)
Query: 110 DLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKP-TVALSAVAGASQVKWNKKNANCLATSH 168
D+ W+ +L+T S D + +WD P V V W++ L S
Sbjct: 72 DVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSG 131
Query: 169 DGD--VRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRK 226
D V++WD + + H S I+ W P A++S D +++ WD +
Sbjct: 132 SWDQTVKLWDPTVGKSLCTF-RGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGV 190
Query: 227 YLNILPCQVPVWKARYTPFS-NGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVV 285
+ I Q + + ++ N LVT V + SL W++ ++ PV +GH +
Sbjct: 191 RIVIPAHQAEILSCDWCKYNENLLVTGAV-----DCSLRGWDLRNVRQPVFELLGHTYAI 245
Query: 286 LEFQWRKQKEGSKDYQLVTWSRDQTLRMW 314
++ L + S D T+R W
Sbjct: 246 RRVKFSPFHAS----VLASCSYDFTVRFW 270
Score = 39.7 bits (91), Expect = 0.014
Identities = 33/134 (24%), Positives = 55/134 (41%), Gaps = 25/134 (18%)
Query: 199 WHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQLR 258
W ++EH+L T S D S++ WD + L + Y + + +V Q R
Sbjct: 75 WSENNEHVLITCSGDGSLQLWDTAKAAGPLQV-----------YKEHAQEVYSVDWSQTR 123
Query: 259 RENSLL---------LWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDYQLVTWSRDQ 309
E ++ LW+ + + TF GH+ ++ W G + S DQ
Sbjct: 124 GEQLVVSGSWDQTVKLWDP-TVGKSLCTFRGHESIIYSTIWSPHIPGC----FASASGDQ 178
Query: 310 TLRMWRVDSQMQRL 323
TLR+W V + R+
Sbjct: 179 TLRIWDVKAAGVRI 192
>gi|207029439 retinoblastoma binding protein 4 isoform c [Homo
sapiens]
Length = 390
Score = 72.0 bits (175), Expect = 3e-12
Identities = 54/187 (28%), Positives = 86/187 (45%), Gaps = 17/187 (9%)
Query: 43 NLDAPFEGHRKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKW----KDGSG-EV 97
N D GH+K + WNP+ S H +AS + + L+ K+G +
Sbjct: 133 NPDLRLRGHQKEGY-------GLSWNPNLS-GHLLSASDDHTICLWDISAVPKEGKVVDA 184
Query: 98 GTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIK--DTRKPTVALSA-VAGASQV 154
T GHT V+ D+ W + L + + D + IWD + +T KP+ ++ A A + +
Sbjct: 185 KTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCL 244
Query: 155 KWNKKNANCLAT-SHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQD 213
+N + LAT S D V +WD R + +H +I + W P +E ILA+S D
Sbjct: 245 SFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTD 304
Query: 214 NSVKFWD 220
+ WD
Sbjct: 305 RRLNVWD 311
Score = 60.1 bits (144), Expect = 1e-08
Identities = 59/254 (23%), Positives = 111/254 (43%), Gaps = 40/254 (15%)
Query: 92 DGSGEVGTTLQ--GHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKP-------T 142
D SGE L+ GH + L W L+++S D I +WDI K T
Sbjct: 127 DPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKT 186
Query: 143 VALSAVAGASQVKWNKKNANCLAT-SHDGDVRIWDKR-----KPSTAVEYLAAHLSKIHG 196
+ A V W+ + + + + D + IWD R KPS +V+ AH ++++
Sbjct: 187 IFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVD---AHTAEVNC 243
Query: 197 LDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPC-QVPVWKARYTPFSNGLVTVMVP 255
L ++P SE ILAT S D +V WD R + L+ + +++ +++P + ++
Sbjct: 244 LSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNE----TILA 299
Query: 256 QLRRENSLLLWNVFDL-----------NTPVHTFV--GHDDVVLEFQWRKQKEGSKDYQL 302
+ L +W++ + P F+ GH + +F W ++ + +
Sbjct: 300 SSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNP----NEPWVI 355
Query: 303 VTWSRDQTLRMWRV 316
+ S D +++W++
Sbjct: 356 CSVSEDNIMQVWQM 369
Score = 37.0 bits (84), Expect = 0.090
Identities = 29/104 (27%), Positives = 42/104 (40%), Gaps = 24/104 (23%)
Query: 48 FEGHRKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKW--------------KDG 93
FE H+ +I VQW+PH+ ASS L W +DG
Sbjct: 278 FESHKD-------EIFQVQWSPHNET---ILASSGTDRRLNVWDLSKIGEEQSPEDAEDG 327
Query: 94 SGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKD 137
E+ GHT ISD W EP ++ + S D + +W + +
Sbjct: 328 PPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 371
>gi|207029415 retinoblastoma binding protein 4 isoform b [Homo
sapiens]
Length = 424
Score = 72.0 bits (175), Expect = 3e-12
Identities = 54/187 (28%), Positives = 86/187 (45%), Gaps = 17/187 (9%)
Query: 43 NLDAPFEGHRKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKW----KDGSG-EV 97
N D GH+K + WNP+ S H +AS + + L+ K+G +
Sbjct: 167 NPDLRLRGHQKEGY-------GLSWNPNLS-GHLLSASDDHTICLWDISAVPKEGKVVDA 218
Query: 98 GTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIK--DTRKPTVALSA-VAGASQV 154
T GHT V+ D+ W + L + + D + IWD + +T KP+ ++ A A + +
Sbjct: 219 KTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCL 278
Query: 155 KWNKKNANCLAT-SHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQD 213
+N + LAT S D V +WD R + +H +I + W P +E ILA+S D
Sbjct: 279 SFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTD 338
Query: 214 NSVKFWD 220
+ WD
Sbjct: 339 RRLNVWD 345
Score = 60.1 bits (144), Expect = 1e-08
Identities = 59/254 (23%), Positives = 111/254 (43%), Gaps = 40/254 (15%)
Query: 92 DGSGEVGTTLQ--GHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKP-------T 142
D SGE L+ GH + L W L+++S D I +WDI K T
Sbjct: 161 DPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKT 220
Query: 143 VALSAVAGASQVKWNKKNANCLAT-SHDGDVRIWDKR-----KPSTAVEYLAAHLSKIHG 196
+ A V W+ + + + + D + IWD R KPS +V+ AH ++++
Sbjct: 221 IFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVD---AHTAEVNC 277
Query: 197 LDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPC-QVPVWKARYTPFSNGLVTVMVP 255
L ++P SE ILAT S D +V WD R + L+ + +++ +++P + ++
Sbjct: 278 LSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNE----TILA 333
Query: 256 QLRRENSLLLWNVFDL-----------NTPVHTFV--GHDDVVLEFQWRKQKEGSKDYQL 302
+ L +W++ + P F+ GH + +F W ++ + +
Sbjct: 334 SSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNP----NEPWVI 389
Query: 303 VTWSRDQTLRMWRV 316
+ S D +++W++
Sbjct: 390 CSVSEDNIMQVWQM 403
Score = 37.0 bits (84), Expect = 0.090
Identities = 29/104 (27%), Positives = 42/104 (40%), Gaps = 24/104 (23%)
Query: 48 FEGHRKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKW--------------KDG 93
FE H+ +I VQW+PH+ ASS L W +DG
Sbjct: 312 FESHKD-------EIFQVQWSPHNET---ILASSGTDRRLNVWDLSKIGEEQSPEDAEDG 361
Query: 94 SGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKD 137
E+ GHT ISD W EP ++ + S D + +W + +
Sbjct: 362 PPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 405
>gi|5032027 retinoblastoma binding protein 4 isoform a [Homo
sapiens]
Length = 425
Score = 72.0 bits (175), Expect = 3e-12
Identities = 54/187 (28%), Positives = 86/187 (45%), Gaps = 17/187 (9%)
Query: 43 NLDAPFEGHRKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKW----KDGSG-EV 97
N D GH+K + WNP+ S H +AS + + L+ K+G +
Sbjct: 168 NPDLRLRGHQKEGY-------GLSWNPNLS-GHLLSASDDHTICLWDISAVPKEGKVVDA 219
Query: 98 GTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIK--DTRKPTVALSA-VAGASQV 154
T GHT V+ D+ W + L + + D + IWD + +T KP+ ++ A A + +
Sbjct: 220 KTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCL 279
Query: 155 KWNKKNANCLAT-SHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQD 213
+N + LAT S D V +WD R + +H +I + W P +E ILA+S D
Sbjct: 280 SFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTD 339
Query: 214 NSVKFWD 220
+ WD
Sbjct: 340 RRLNVWD 346
Score = 60.1 bits (144), Expect = 1e-08
Identities = 59/254 (23%), Positives = 111/254 (43%), Gaps = 40/254 (15%)
Query: 92 DGSGEVGTTLQ--GHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKP-------T 142
D SGE L+ GH + L W L+++S D I +WDI K T
Sbjct: 162 DPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKT 221
Query: 143 VALSAVAGASQVKWNKKNANCLAT-SHDGDVRIWDKR-----KPSTAVEYLAAHLSKIHG 196
+ A V W+ + + + + D + IWD R KPS +V+ AH ++++
Sbjct: 222 IFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVD---AHTAEVNC 278
Query: 197 LDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPC-QVPVWKARYTPFSNGLVTVMVP 255
L ++P SE ILAT S D +V WD R + L+ + +++ +++P + ++
Sbjct: 279 LSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNE----TILA 334
Query: 256 QLRRENSLLLWNVFDL-----------NTPVHTFV--GHDDVVLEFQWRKQKEGSKDYQL 302
+ L +W++ + P F+ GH + +F W ++ + +
Sbjct: 335 SSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNP----NEPWVI 390
Query: 303 VTWSRDQTLRMWRV 316
+ S D +++W++
Sbjct: 391 CSVSEDNIMQVWQM 404
Score = 37.0 bits (84), Expect = 0.090
Identities = 29/104 (27%), Positives = 42/104 (40%), Gaps = 24/104 (23%)
Query: 48 FEGHRKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKW--------------KDG 93
FE H+ +I VQW+PH+ ASS L W +DG
Sbjct: 313 FESHKD-------EIFQVQWSPHNET---ILASSGTDRRLNVWDLSKIGEEQSPEDAEDG 362
Query: 94 SGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKD 137
E+ GHT ISD W EP ++ + S D + +W + +
Sbjct: 363 PPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 68.9 bits (167), Expect = 2e-11
Identities = 66/262 (25%), Positives = 120/262 (45%), Gaps = 18/262 (6%)
Query: 59 KWDIGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEP 118
K I V W+ S ++ ++S+ + L W SG+ TL+GH+ + ++ +
Sbjct: 87 KLGISDVAWS---SDSNLLVSASDDKT-LKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QS 141
Query: 119 DLLVTSSVDTYIYIWDIKDTRKPTVALSAVAG-ASQVKWNKKNANCLATSHDGDVRIWDK 177
+L+V+ S D + IWD+K T K L A + S V +N+ + +++S+DG RIWD
Sbjct: 142 NLIVSGSFDESVRIWDVK-TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
Query: 178 RKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPCQVPV 237
+ + + + P+ ++ILA ++ DN++K WDY + + L
Sbjct: 201 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILA-ATLDNTLKLWDYSKGK----CLKTYTGH 255
Query: 238 WKARYTPFSNGLVT--VMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKE 295
+Y F+N VT + +N + +WN+ V GH DVV+ +
Sbjct: 256 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL-QTKEIVQKLQGHTDVVISTACHPTEN 314
Query: 296 GSKDYQLVTWSRDQTLRMWRVD 317
L D+T+++W+ D
Sbjct: 315 IIASAAL---ENDKTIKLWKSD 333
Score = 54.7 bits (130), Expect = 4e-07
Identities = 37/133 (27%), Positives = 64/133 (48%), Gaps = 4/133 (3%)
Query: 100 TLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVAGASQVKWNKK 159
TL GHT+ +S + ++ + L +SS D I IW D + G S V W+
Sbjct: 40 TLAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98
Query: 160 NANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFW 219
+ ++ S D ++IWD ++ L H + + +++P S +++ + S D SV+ W
Sbjct: 99 SNLLVSASDDKTLKIWDV-SSGKCLKTLKGHSNYVFCCNFNPQS-NLIVSGSFDESVRIW 156
Query: 220 DYRQPRKYLNILP 232
D + K L LP
Sbjct: 157 DVK-TGKCLKTLP 168
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 68.9 bits (167), Expect = 2e-11
Identities = 66/262 (25%), Positives = 120/262 (45%), Gaps = 18/262 (6%)
Query: 59 KWDIGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEP 118
K I V W+ S ++ ++S+ + L W SG+ TL+GH+ + ++ +
Sbjct: 87 KLGISDVAWS---SDSNLLVSASDDKT-LKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QS 141
Query: 119 DLLVTSSVDTYIYIWDIKDTRKPTVALSAVAG-ASQVKWNKKNANCLATSHDGDVRIWDK 177
+L+V+ S D + IWD+K T K L A + S V +N+ + +++S+DG RIWD
Sbjct: 142 NLIVSGSFDESVRIWDVK-TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
Query: 178 RKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPCQVPV 237
+ + + + P+ ++ILA ++ DN++K WDY + + L
Sbjct: 201 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILA-ATLDNTLKLWDYSKGK----CLKTYTGH 255
Query: 238 WKARYTPFSNGLVT--VMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKE 295
+Y F+N VT + +N + +WN+ V GH DVV+ +
Sbjct: 256 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL-QTKEIVQKLQGHTDVVISTACHPTEN 314
Query: 296 GSKDYQLVTWSRDQTLRMWRVD 317
L D+T+++W+ D
Sbjct: 315 IIASAAL---ENDKTIKLWKSD 333
Score = 54.7 bits (130), Expect = 4e-07
Identities = 37/133 (27%), Positives = 64/133 (48%), Gaps = 4/133 (3%)
Query: 100 TLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVAGASQVKWNKK 159
TL GHT+ +S + ++ + L +SS D I IW D + G S V W+
Sbjct: 40 TLAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98
Query: 160 NANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFW 219
+ ++ S D ++IWD ++ L H + + +++P S +++ + S D SV+ W
Sbjct: 99 SNLLVSASDDKTLKIWDV-SSGKCLKTLKGHSNYVFCCNFNPQS-NLIVSGSFDESVRIW 156
Query: 220 DYRQPRKYLNILP 232
D + K L LP
Sbjct: 157 DVK-TGKCLKTLP 168
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 66.6 bits (161), Expect = 1e-10
Identities = 60/230 (26%), Positives = 101/230 (43%), Gaps = 17/230 (7%)
Query: 90 WKDGSGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVA 149
W S E ++GHT ++ + W L T+ D +WD++ +
Sbjct: 308 WSLDSDEPVADIEGHTVRVARVMWHP-SGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSM 366
Query: 150 GASQVKWNKKNANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILAT 209
G + +++ + D R+WD R + +L HL +I+G+++ P+ HI AT
Sbjct: 367 GVYDIAFHQDGSLAGTGGLDAFGRVWDLRT-GRCIMFLEGHLKEIYGINFSPNGYHI-AT 424
Query: 210 SSQDNSVKFWDYRQPRKYLNILPCQVPVWKARYTPF-SNGLVTVMVPQLRRENSLLLWNV 268
S DN+ K WD RQ R I Q V ++ P N L+T +N+ +W
Sbjct: 425 GSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAY-----DNTAKIW-T 478
Query: 269 FDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDYQLV-TWSRDQTLRMWRVD 317
+P+ T GH+ V+ + S D QL+ T S D+T ++W +
Sbjct: 479 HPGWSPLKTLAGHEGKVMGL------DISSDGQLIATCSYDRTFKLWMAE 522
Score = 39.3 bits (90), Expect = 0.018
Identities = 23/80 (28%), Positives = 38/80 (47%), Gaps = 6/80 (7%)
Query: 152 SQVKWNKKNANCLATSHDGDVRIW--DKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILAT 209
S V + K+ N + + DG V++W D +P +E H ++ + WHP S L T
Sbjct: 285 STVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIE---GHTVRVARVMWHP-SGRFLGT 340
Query: 210 SSQDNSVKFWDYRQPRKYLN 229
+ D S + WD + L+
Sbjct: 341 TCYDRSWRLWDLEAQEEILH 360
Score = 30.4 bits (67), Expect = 8.4
Identities = 24/86 (27%), Positives = 40/86 (46%), Gaps = 9/86 (10%)
Query: 236 PVWKARYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKE 295
P+ ++P S L T L + LW+V D N +HT GH+ V + +
Sbjct: 233 PISYCHFSPNSKMLATACWSGLCK-----LWSVPDCNL-LHTLRGHNTNVGAIVFHPKST 286
Query: 296 GS---KDYQLVTWSRDQTLRMWRVDS 318
S KD L + + D ++++W +DS
Sbjct: 287 VSLDPKDVNLASCAADGSVKLWSLDS 312
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 65.9 bits (159), Expect = 2e-10
Identities = 67/259 (25%), Positives = 116/259 (44%), Gaps = 22/259 (8%)
Query: 61 DIGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEP-- 118
+I V W+ S +AS ++ + L W SG+ TL+GH+ + + F P
Sbjct: 85 EISDVAWSSDSS--RLVSASDDKTLKL--WDVRSGKCLKTLKGHSNYVFCCN---FNPPS 137
Query: 119 DLLVTSSVDTYIYIWDIKDTRKPTVALSAVAG-ASQVKWNKKNANCLATSHDGDVRIWDK 177
+L+++ S D + IW++K T K LSA + S V +N + ++ S+DG RIWD
Sbjct: 138 NLIISGSFDETVKIWEVK-TGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDA 196
Query: 178 RKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPCQVPV 237
+ + + + P+ ++IL T++ DN++K WDY + R L
Sbjct: 197 ASGQCLKTLVDDDNPPVSFVKFSPNGKYIL-TATLDNTLKLWDYSRGR----CLKTYTGH 251
Query: 238 WKARYTPFSNGLVT--VMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKE 295
+Y F+N VT + +N + +WN+ V GH DVV+ +
Sbjct: 252 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL-QTKEIVQKLQGHTDVVISAACHPTEN 310
Query: 296 GSKDYQLVTWSRDQTLRMW 314
L D+T+++W
Sbjct: 311 LIASAAL---ENDKTIKLW 326
Score = 53.5 bits (127), Expect = 9e-07
Identities = 47/215 (21%), Positives = 92/215 (42%), Gaps = 13/215 (6%)
Query: 100 TLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVAGASQVKWNKK 159
TL GHT +S + ++ + L +SS D I IW D + S V W+
Sbjct: 36 TLVGHTEAVSSVKFSP-NGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSD 94
Query: 160 NANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFW 219
++ ++ S D +++WD R ++ L H + + +++P S +++ + S D +VK W
Sbjct: 95 SSRLVSASDDKTLKLWDVRS-GKCLKTLKGHSNYVFCCNFNPPS-NLIISGSFDETVKIW 152
Query: 220 DYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFV 279
+ + + + PV + + +V+ L R +W+ + T V
Sbjct: 153 EVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCR-----IWDAAS-GQCLKTLV 206
Query: 280 GHDDVVLEFQWRKQKEGSKDYQLVTWSRDQTLRMW 314
D+ + F K ++T + D TL++W
Sbjct: 207 DDDNPPVSF----VKFSPNGKYILTATLDNTLKLW 237
>gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]
Length = 425
Score = 65.5 bits (158), Expect = 2e-10
Identities = 52/187 (27%), Positives = 80/187 (42%), Gaps = 17/187 (9%)
Query: 43 NLDAPFEGHRKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGE-----V 97
N D GH+K + WN + S H +AS + V L+ G E
Sbjct: 167 NPDLRLRGHQKEGY-------GLSWNSNLS-GHLLSASDDHTVCLWDINAGPKEGKIVDA 218
Query: 98 GTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKD--TRKPTVALSA-VAGASQV 154
GH+ V+ D+ W + L + + D + IWD + T KP+ + A A + +
Sbjct: 219 KAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCL 278
Query: 155 KWNKKNANCLAT-SHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQD 213
+N + LAT S D V +WD R + +H +I + W P +E ILA+S D
Sbjct: 279 SFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTD 338
Query: 214 NSVKFWD 220
+ WD
Sbjct: 339 RRLNVWD 345
Score = 57.4 bits (137), Expect = 6e-08
Identities = 62/260 (23%), Positives = 94/260 (36%), Gaps = 69/260 (26%)
Query: 92 DGSGEVGTTLQ--GHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVA 149
D SGE L+ GH + L W L+++S D + +WDI K + A A
Sbjct: 161 DPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKA 220
Query: 150 -------GASQVKWNKKNANCLAT-SHDGDVRIWDKR-----KPSTAVEYLAAHLSKIHG 196
V W+ + + + + D + IWD R KPS V+ AH ++++
Sbjct: 221 IFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVD---AHTAEVNC 277
Query: 197 LDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQ 256
L ++P SE ILAT S D +V WD R
Sbjct: 278 LSFNPYSEFILATGSADKTVALWDLR---------------------------------- 303
Query: 257 LRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDYQLVTWSRDQTLRMWRV 316
+L +HTF H D + + W E L + D+ L +W +
Sbjct: 304 -------------NLKLKLHTFESHKDEIFQVHWSPHNETI----LASSGTDRRLNVWDL 346
Query: 317 DSQMQRLCANDILDGVDEFI 336
+ A D DG E +
Sbjct: 347 SKIGEEQSAEDAEDGPPELL 366
Score = 35.4 bits (80), Expect = 0.26
Identities = 29/104 (27%), Positives = 41/104 (39%), Gaps = 24/104 (23%)
Query: 48 FEGHRKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKW--------------KDG 93
FE H+ +I V W+PH+ ASS L W +DG
Sbjct: 312 FESHKD-------EIFQVHWSPHNET---ILASSGTDRRLNVWDLSKIGEEQSAEDAEDG 361
Query: 94 SGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKD 137
E+ GHT ISD W EP ++ + S D + IW + +
Sbjct: 362 PPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAE 405
>gi|14149696 SEC31 homolog B [Homo sapiens]
Length = 1179
Score = 65.1 bits (157), Expect = 3e-10
Identities = 41/140 (29%), Positives = 72/140 (51%), Gaps = 11/140 (7%)
Query: 102 QGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKP-TVALSAVAGASQVK---WN 157
Q HT + LD F+ +LL + + D+ I+IWD+ + P T+ + +K WN
Sbjct: 118 QKHTGAVRALDLNPFQGNLLASGASDSEIFIWDLNNLNVPMTLGSKSQQPPEDIKALSWN 177
Query: 158 KKNANCLATSH-DGDVRIWDKRKPSTAVEYLAAHLSKIH--GLDWHPDSEHILATSSQDN 214
++ + L+++H G +WD RK ++ ++ H +++H GL WHPD L S+D+
Sbjct: 178 RQAQHILSSAHPSGKAVVWDLRKNEPIIK-VSDHSNRMHCSGLAWHPDIATQLVLCSEDD 236
Query: 215 S---VKFWDYRQPRKYLNIL 231
++ WD R L +L
Sbjct: 237 RLPVIQLWDLRFASSPLKVL 256
>gi|4507703 tumor suppressing subtransferable candidate 1 [Homo
sapiens]
Length = 387
Score = 64.3 bits (155), Expect = 5e-10
Identities = 47/187 (25%), Positives = 87/187 (46%), Gaps = 13/187 (6%)
Query: 122 VTSSVDTYIYIWDIKDTRKPTVALSAVA--GASQVKWNK------KNANCLATSHDGDVR 173
+ S D +I +WD++++ V S+ + G Q+K+ N +AT++D +R
Sbjct: 151 IISLADNHILLWDLQESSSQAVLASSASLEGKGQLKFTSGRWSPHHNCTQVATANDTTLR 210
Query: 174 IWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPC 233
WD R S AH + LD++P+ ++ LA+ D VKFWD R + + L
Sbjct: 211 GWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTLEE 270
Query: 234 QVP-VWKARYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRK 292
VW RY + LV ++ ++L N+ +++ + DD + + + +
Sbjct: 271 HSHWVWNVRYNHSHDQLVLTG----SSDSRVILSNMVSISSEPFGHLVDDDDISDQEDHR 326
Query: 293 QKEGSKD 299
+E SK+
Sbjct: 327 SEEKSKE 333
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 62.4 bits (150), Expect = 2e-09
Identities = 56/219 (25%), Positives = 91/219 (41%), Gaps = 23/219 (10%)
Query: 104 HTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVAGAS---QVKWNKKN 160
H +S L LL T D + +W I KP +S S V+ N
Sbjct: 19 HASNVSSLVLGKASGRLLATGGDDCRVNLWSIN---KPNCIMSLTGHTSPVESVRLNTPE 75
Query: 161 ANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWD 220
+A S G +R+WD + + + L H + I LD+HP E + A+ SQD ++K WD
Sbjct: 76 ELIVAGSQSGSIRVWDL-EAAKILRTLMGHKANICSLDFHPYGEFV-ASGSQDTNIKLWD 133
Query: 221 YRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVG 280
R+ V R++P L + ++++ LW++ + F G
Sbjct: 134 IRRKGCVFRYRGHSQAVRCLRFSPDGKWLASA-----ADDHTVKLWDL-TAGKMMSEFPG 187
Query: 281 HDDV--VLEFQWRKQKEGSKDYQLVTWSRDQTLRMWRVD 317
H V+EF +Y L + S D+T+R W ++
Sbjct: 188 HTGPVNVVEFH-------PNEYLLASGSSDRTIRFWDLE 219
Score = 52.8 bits (125), Expect = 2e-06
Identities = 37/147 (25%), Positives = 70/147 (47%), Gaps = 15/147 (10%)
Query: 80 SSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDT- 138
+ +Q + W + ++ TL GH I LD+ + + + + S DT I +WDI+
Sbjct: 80 AGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYG-EFVASGSQDTNIKLWDIRRKG 138
Query: 139 -----RKPTVALSAVAGASQVKWNKKNANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSK 193
R + A+ + + KW A+ D V++WD E+ H
Sbjct: 139 CVFRYRGHSQAVRCLRFSPDGKWLASAAD------DHTVKLWDLTAGKMMSEF-PGHTGP 191
Query: 194 IHGLDWHPDSEHILATSSQDNSVKFWD 220
++ +++HP+ E++LA+ S D +++FWD
Sbjct: 192 VNVVEFHPN-EYLLASGSSDRTIRFWD 217
Score = 31.2 bits (69), Expect = 4.9
Identities = 28/132 (21%), Positives = 52/132 (39%), Gaps = 12/132 (9%)
Query: 179 KPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPCQVPVW 238
K + ++ + AH S + L S +LAT D V W +P +++ PV
Sbjct: 8 KTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVE 67
Query: 239 KARY-TPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKE-- 295
R TP ++ + S+ +W++ + + T +GH + + E
Sbjct: 68 SVRLNTP------EELIVAGSQSGSIRVWDL-EAAKILRTLMGHKANICSLDFHPYGEFV 120
Query: 296 --GSKDYQLVTW 305
GS+D + W
Sbjct: 121 ASGSQDTNIKLW 132
>gi|116256340 SEC31 homolog A isoform 3 [Homo sapiens]
Length = 1205
Score = 61.2 bits (147), Expect = 4e-09
Identities = 38/137 (27%), Positives = 69/137 (50%), Gaps = 10/137 (7%)
Query: 104 HTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKD---TRKPTVALSAVAGASQVKWNKKN 160
HT + LD +F+ +L+ + + ++ IYIWD+ + P S + WN++
Sbjct: 121 HTGPVRALDVNIFQTNLVASGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQV 180
Query: 161 ANCLAT-SHDGDVRIWDKRKPSTAVEYLAAHLSKIH--GLDWHPDSEHILATSSQDNS-- 215
+ LA+ S G +WD RK ++ ++ H +++H GL WHPD + +S+D+
Sbjct: 181 QHILASASPSGRATVWDLRKNEPIIK-VSDHSNRMHCSGLAWHPDVATQMVLASEDDRLP 239
Query: 216 -VKFWDYRQPRKYLNIL 231
++ WD R L +L
Sbjct: 240 VIQMWDLRFASSPLRVL 256
Score = 30.8 bits (68), Expect = 6.5
Identities = 29/154 (18%), Positives = 59/154 (38%), Gaps = 11/154 (7%)
Query: 73 FAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLD---WAVFEPDLLVTSSVDTY 129
F AS ++Y W + T T+ D+ W +L ++S
Sbjct: 133 FQTNLVASGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGR 192
Query: 130 IYIWDIKDTRKPTVALSAVAG---ASQVKWNKKNANCLATSHDGD----VRIWDKRKPST 182
+WD++ +P + +S + S + W+ A + + + D +++WD R S+
Sbjct: 193 ATVWDLRKN-EPIIKVSDHSNRMHCSGLAWHPDVATQMVLASEDDRLPVIQMWDLRFASS 251
Query: 183 AVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSV 216
+ L H I + W +L + +D +
Sbjct: 252 PLRVLENHARGILAIAWSMADPELLLSCGKDAKI 285
>gi|116256338 SEC31 homolog A isoform 1 [Homo sapiens]
Length = 1220
Score = 61.2 bits (147), Expect = 4e-09
Identities = 38/137 (27%), Positives = 69/137 (50%), Gaps = 10/137 (7%)
Query: 104 HTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKD---TRKPTVALSAVAGASQVKWNKKN 160
HT + LD +F+ +L+ + + ++ IYIWD+ + P S + WN++
Sbjct: 121 HTGPVRALDVNIFQTNLVASGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQV 180
Query: 161 ANCLAT-SHDGDVRIWDKRKPSTAVEYLAAHLSKIH--GLDWHPDSEHILATSSQDNS-- 215
+ LA+ S G +WD RK ++ ++ H +++H GL WHPD + +S+D+
Sbjct: 181 QHILASASPSGRATVWDLRKNEPIIK-VSDHSNRMHCSGLAWHPDVATQMVLASEDDRLP 239
Query: 216 -VKFWDYRQPRKYLNIL 231
++ WD R L +L
Sbjct: 240 VIQMWDLRFASSPLRVL 256
Score = 30.8 bits (68), Expect = 6.5
Identities = 29/154 (18%), Positives = 59/154 (38%), Gaps = 11/154 (7%)
Query: 73 FAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLD---WAVFEPDLLVTSSVDTY 129
F AS ++Y W + T T+ D+ W +L ++S
Sbjct: 133 FQTNLVASGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGR 192
Query: 130 IYIWDIKDTRKPTVALSAVAG---ASQVKWNKKNANCLATSHDGD----VRIWDKRKPST 182
+WD++ +P + +S + S + W+ A + + + D +++WD R S+
Sbjct: 193 ATVWDLRKN-EPIIKVSDHSNRMHCSGLAWHPDVATQMVLASEDDRLPVIQMWDLRFASS 251
Query: 183 AVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSV 216
+ L H I + W +L + +D +
Sbjct: 252 PLRVLENHARGILAIAWSMADPELLLSCGKDAKI 285
>gi|116256336 SEC31 homolog A isoform 4 [Homo sapiens]
Length = 1106
Score = 61.2 bits (147), Expect = 4e-09
Identities = 38/137 (27%), Positives = 69/137 (50%), Gaps = 10/137 (7%)
Query: 104 HTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKD---TRKPTVALSAVAGASQVKWNKKN 160
HT + LD +F+ +L+ + + ++ IYIWD+ + P S + WN++
Sbjct: 121 HTGPVRALDVNIFQTNLVASGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQV 180
Query: 161 ANCLAT-SHDGDVRIWDKRKPSTAVEYLAAHLSKIH--GLDWHPDSEHILATSSQDNS-- 215
+ LA+ S G +WD RK ++ ++ H +++H GL WHPD + +S+D+
Sbjct: 181 QHILASASPSGRATVWDLRKNEPIIK-VSDHSNRMHCSGLAWHPDVATQMVLASEDDRLP 239
Query: 216 -VKFWDYRQPRKYLNIL 231
++ WD R L +L
Sbjct: 240 VIQMWDLRFASSPLRVL 256
Score = 30.8 bits (68), Expect = 6.5
Identities = 29/154 (18%), Positives = 59/154 (38%), Gaps = 11/154 (7%)
Query: 73 FAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLD---WAVFEPDLLVTSSVDTY 129
F AS ++Y W + T T+ D+ W +L ++S
Sbjct: 133 FQTNLVASGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGR 192
Query: 130 IYIWDIKDTRKPTVALSAVAG---ASQVKWNKKNANCLATSHDGD----VRIWDKRKPST 182
+WD++ +P + +S + S + W+ A + + + D +++WD R S+
Sbjct: 193 ATVWDLRKN-EPIIKVSDHSNRMHCSGLAWHPDVATQMVLASEDDRLPVIQMWDLRFASS 251
Query: 183 AVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSV 216
+ L H I + W +L + +D +
Sbjct: 252 PLRVLENHARGILAIAWSMADPELLLSCGKDAKI 285
>gi|41349441 SEC31 homolog A isoform 2 [Homo sapiens]
Length = 1181
Score = 61.2 bits (147), Expect = 4e-09
Identities = 38/137 (27%), Positives = 69/137 (50%), Gaps = 10/137 (7%)
Query: 104 HTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKD---TRKPTVALSAVAGASQVKWNKKN 160
HT + LD +F+ +L+ + + ++ IYIWD+ + P S + WN++
Sbjct: 121 HTGPVRALDVNIFQTNLVASGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQV 180
Query: 161 ANCLAT-SHDGDVRIWDKRKPSTAVEYLAAHLSKIH--GLDWHPDSEHILATSSQDNS-- 215
+ LA+ S G +WD RK ++ ++ H +++H GL WHPD + +S+D+
Sbjct: 181 QHILASASPSGRATVWDLRKNEPIIK-VSDHSNRMHCSGLAWHPDVATQMVLASEDDRLP 239
Query: 216 -VKFWDYRQPRKYLNIL 231
++ WD R L +L
Sbjct: 240 VIQMWDLRFASSPLRVL 256
Score = 30.8 bits (68), Expect = 6.5
Identities = 29/154 (18%), Positives = 59/154 (38%), Gaps = 11/154 (7%)
Query: 73 FAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLD---WAVFEPDLLVTSSVDTY 129
F AS ++Y W + T T+ D+ W +L ++S
Sbjct: 133 FQTNLVASGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGR 192
Query: 130 IYIWDIKDTRKPTVALSAVAG---ASQVKWNKKNANCLATSHDGD----VRIWDKRKPST 182
+WD++ +P + +S + S + W+ A + + + D +++WD R S+
Sbjct: 193 ATVWDLRKN-EPIIKVSDHSNRMHCSGLAWHPDVATQMVLASEDDRLPVIQMWDLRFASS 251
Query: 183 AVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSV 216
+ L H I + W +L + +D +
Sbjct: 252 PLRVLENHARGILAIAWSMADPELLLSCGKDAKI 285
>gi|41349439 SEC31 homolog A isoform 1 [Homo sapiens]
Length = 1220
Score = 61.2 bits (147), Expect = 4e-09
Identities = 38/137 (27%), Positives = 69/137 (50%), Gaps = 10/137 (7%)
Query: 104 HTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKD---TRKPTVALSAVAGASQVKWNKKN 160
HT + LD +F+ +L+ + + ++ IYIWD+ + P S + WN++
Sbjct: 121 HTGPVRALDVNIFQTNLVASGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQV 180
Query: 161 ANCLAT-SHDGDVRIWDKRKPSTAVEYLAAHLSKIH--GLDWHPDSEHILATSSQDNS-- 215
+ LA+ S G +WD RK ++ ++ H +++H GL WHPD + +S+D+
Sbjct: 181 QHILASASPSGRATVWDLRKNEPIIK-VSDHSNRMHCSGLAWHPDVATQMVLASEDDRLP 239
Query: 216 -VKFWDYRQPRKYLNIL 231
++ WD R L +L
Sbjct: 240 VIQMWDLRFASSPLRVL 256
Score = 30.8 bits (68), Expect = 6.5
Identities = 29/154 (18%), Positives = 59/154 (38%), Gaps = 11/154 (7%)
Query: 73 FAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLD---WAVFEPDLLVTSSVDTY 129
F AS ++Y W + T T+ D+ W +L ++S
Sbjct: 133 FQTNLVASGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGR 192
Query: 130 IYIWDIKDTRKPTVALSAVAG---ASQVKWNKKNANCLATSHDGD----VRIWDKRKPST 182
+WD++ +P + +S + S + W+ A + + + D +++WD R S+
Sbjct: 193 ATVWDLRKN-EPIIKVSDHSNRMHCSGLAWHPDVATQMVLASEDDRLPVIQMWDLRFASS 251
Query: 183 AVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSV 216
+ L H I + W +L + +D +
Sbjct: 252 PLRVLENHARGILAIAWSMADPELLLSCGKDAKI 285
>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
Length = 193
Score = 58.5 bits (140), Expect = 3e-08
Identities = 30/123 (24%), Positives = 63/123 (51%), Gaps = 7/123 (5%)
Query: 99 TTLQGHTRVISDLDWAVFEPD--LLVTSSVDTYIYIWDIKDTRKPTVALSAVAGASQVKW 156
T + GH +I+ + +F PD ++ ++S D I +WD + + VA Q+ W
Sbjct: 74 TRMTGHQALINQV---LFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAW 130
Query: 157 NKKNANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSV 216
+ + ++ S D +++WD + A++ L H +++ +DW PD + + A+ +D +
Sbjct: 131 SADSRLLVSGSSDSTLKVWDVKAQKLAMD-LPGHADEVYAVDWSPDGQRV-ASGGKDKCL 188
Query: 217 KFW 219
+ W
Sbjct: 189 RIW 191
Score = 50.4 bits (119), Expect = 8e-06
Identities = 27/114 (23%), Positives = 60/114 (52%), Gaps = 3/114 (2%)
Query: 118 PDLLVTSSVDTYIYIWDIKDTRKPTVALSA-VAGASQVKWNKKNANCLATSHDGDVRIWD 176
P+ LV+ S D +++W + +KP ++ A +QV ++ + + S D +++WD
Sbjct: 49 PERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD 108
Query: 177 KRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNI 230
R + L H++ ++ + W DS +L + S D+++K WD + + +++
Sbjct: 109 GR-TGKYLASLRGHVAAVYQIAWSADS-RLLVSGSSDSTLKVWDVKAQKLAMDL 160
Score = 41.6 bits (96), Expect = 0.004
Identities = 34/149 (22%), Positives = 67/149 (44%), Gaps = 12/149 (8%)
Query: 167 SHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRK 226
S D + +W + + + H + I+ + + PDS I+A++S D S+K WD R +
Sbjct: 56 SDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSR-IVASASFDKSIKLWDGRTGKY 114
Query: 227 YLNILPCQVPVWKARYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVL 286
++ V++ ++ S LV+ +++L +W+V GH D V
Sbjct: 115 LASLRGHVAAVYQIAWSADSRLLVSG-----SSDSTLKVWDV-KAQKLAMDLPGHADEVY 168
Query: 287 EFQWRKQKEGSKDYQLVTWSRDQTLRMWR 315
W + ++ + +D+ LR+WR
Sbjct: 169 AVDWSPDGQ-----RVASGGKDKCLRIWR 192
Score = 38.1 bits (87), Expect = 0.040
Identities = 22/97 (22%), Positives = 42/97 (43%), Gaps = 1/97 (1%)
Query: 79 ASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDT 138
AS++ + W +G+ +L+GH + + W+ + LLV+ S D+ + +WD+K
Sbjct: 96 ASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSA-DSRLLVSGSSDSTLKVWDVKAQ 154
Query: 139 RKPTVALSAVAGASQVKWNKKNANCLATSHDGDVRIW 175
+ V W+ + D +RIW
Sbjct: 155 KLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 191
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 58.5 bits (140), Expect = 3e-08
Identities = 30/123 (24%), Positives = 63/123 (51%), Gaps = 7/123 (5%)
Query: 99 TTLQGHTRVISDLDWAVFEPD--LLVTSSVDTYIYIWDIKDTRKPTVALSAVAGASQVKW 156
T + GH +I+ + +F PD ++ ++S D I +WD + + VA Q+ W
Sbjct: 366 TRMTGHQALINQV---LFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAW 422
Query: 157 NKKNANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSV 216
+ + ++ S D +++WD + A++ L H +++ +DW PD + + A+ +D +
Sbjct: 423 SADSRLLVSGSSDSTLKVWDVKAQKLAMD-LPGHADEVYAVDWSPDGQRV-ASGGKDKCL 480
Query: 217 KFW 219
+ W
Sbjct: 481 RIW 483
Score = 50.1 bits (118), Expect = 1e-05
Identities = 65/307 (21%), Positives = 118/307 (38%), Gaps = 58/307 (18%)
Query: 52 RKISRQSKWDIGAVQWNP-HDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISD 110
R ++ SKW G + W P H + + ASS++ + W +G L GHT+ ++
Sbjct: 193 RTLAGHSKWITG-LSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTC 251
Query: 111 LDWAVFEPDLLVTSSVDTYIYIWDIKDTRK-----------PTVALSAVAGASQVKWNKK 159
L W LL ++S D I +W D T+ALS +
Sbjct: 252 LRWG--GDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPA 309
Query: 160 NANC-------------------------------LATSHDGDVRIWDKRKPSTAVEYLA 188
A+ ++ S D + +W + + +
Sbjct: 310 EASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMT 369
Query: 189 AHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPCQVPVWKARYTPFSNG 248
H + I+ + + PDS I+A++S D S+K WD R + ++ V++ ++ S
Sbjct: 370 GHQALINQVLFSPDSR-IVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRL 428
Query: 249 LVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDYQLVTWSRD 308
LV+ +++L +W+V GH D V W + ++ + +D
Sbjct: 429 LVSG-----SSDSTLKVWDV-KAQKLAMDLPGHADEVYAVDWSPDGQ-----RVASGGKD 477
Query: 309 QTLRMWR 315
+ LR+WR
Sbjct: 478 KCLRIWR 484
Score = 48.5 bits (114), Expect = 3e-05
Identities = 31/128 (24%), Positives = 50/128 (39%), Gaps = 9/128 (7%)
Query: 99 TTLQGHTRVISDLDWAVFEPD--LLVTSSVDTYIYIWDIKDTRKPTVALSAVAGASQVKW 156
++L+GH+ + + F P L + S DT + WD+ + W
Sbjct: 108 SSLEGHSEAVISV---AFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISW 164
Query: 157 NKKNANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHP----DSEHILATSSQ 212
+ + +G + +WD LA H I GL W P +A+SS+
Sbjct: 165 SPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSK 224
Query: 213 DNSVKFWD 220
D SV+ WD
Sbjct: 225 DGSVRIWD 232
Score = 37.4 bits (85), Expect = 0.069
Identities = 28/117 (23%), Positives = 50/117 (42%), Gaps = 10/117 (8%)
Query: 64 AVQWNPHDSFAHYFAASSNQRVDLYKWKDGSG-EVGTTLQGHTRVISDLDW----AVFEP 118
++ W+P AS + + W +G +VG TL GH++ I+ L W A E
Sbjct: 161 SISWSPDGRKL----ASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPEC 216
Query: 119 DLLVTSSVDTYIYIWDIKDTRKPTVALSAVAGASQVKWNKKNANCLATSHDGDVRIW 175
+ +SS D + IWD R + + ++W + + S D +++W
Sbjct: 217 RYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWG-GDGLLYSASQDRTIKVW 272
Score = 33.9 bits (76), Expect = 0.76
Identities = 27/141 (19%), Positives = 53/141 (37%), Gaps = 6/141 (4%)
Query: 174 IWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPC 233
I+ R + L H + + + P ++ LA+ S D +V+FWD +
Sbjct: 97 IFRVRAVTRCTSSLEGHSEAVISVAFSPTGKY-LASGSGDTTVRFWDLSTETPHFTCKGH 155
Query: 234 QVPVWKARYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQ 293
+ V ++P L + + +LLW+ T GH + W
Sbjct: 156 RHWVLSISWSPDGRKLASGC-----KNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPL 210
Query: 294 KEGSKDYQLVTWSRDQTLRMW 314
+ + + S+D ++R+W
Sbjct: 211 HANPECRYVASSSKDGSVRIW 231
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 57.4 bits (137), Expect = 6e-08
Identities = 39/149 (26%), Positives = 72/149 (48%), Gaps = 11/149 (7%)
Query: 77 FAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIK 136
F+AS+++ V + W +GE L+GHT ++ A P L+ T S D + +WDI
Sbjct: 125 FSASTDKTVAV--WDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI- 181
Query: 137 DTRKPTVALSAVAGASQ---VKWNKKNANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSK 193
+ A+ Q V +N + ++ D D+++WD R+ + + H
Sbjct: 182 ---RKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQ-NKLTYTMRGHADS 237
Query: 194 IHGLDWHPDSEHILATSSQDNSVKFWDYR 222
+ GL + ++L +++ DN+V+ WD R
Sbjct: 238 VTGLSLSSEGSYLL-SNAMDNTVRVWDVR 265
Score = 46.6 bits (109), Expect = 1e-04
Identities = 44/197 (22%), Positives = 83/197 (42%), Gaps = 14/197 (7%)
Query: 121 LVTSSVDTYIYIWDIKDTRKPTVALSAVAGA-SQVKWNKKNANCLATSHDGDVRIWDKRK 179
L ++ D I +W++ L +GA ++ +N + + S D V +WD +
Sbjct: 81 LASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDS-E 139
Query: 180 PSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPCQVPVWK 239
V+ L H S ++ ++ T S D +VK WD R+ + + V
Sbjct: 140 TGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRK-KAAIQTFQNTYQVLA 198
Query: 240 ARYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKD 299
+ S+ +++ + +N + +W++ N +T GH D V EGS
Sbjct: 199 VTFNDTSDQIISGGI-----DNDIKVWDLRQ-NKLTYTMRGHADSVTGLS--LSSEGS-- 248
Query: 300 YQLVTWSRDQTLRMWRV 316
L++ + D T+R+W V
Sbjct: 249 -YLLSNAMDNTVRVWDV 264
>gi|209969680 Fzr1 protein isoform 1 [Homo sapiens]
Length = 496
Score = 57.0 bits (136), Expect = 8e-08
Identities = 57/236 (24%), Positives = 98/236 (41%), Gaps = 22/236 (9%)
Query: 90 WKDGSGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVA 149
W +G+ + L+GHT + L W + L + S D I DI+ P + +
Sbjct: 256 WDAAAGKKLSMLEGHTARVGALAW---NAEQLSSGSRDRMILQRDIRTP--PLQSERRLQ 310
Query: 150 GASQ----VKWNKKNANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEH 205
G Q +KW+ + + +D + +W+ S +Y HL+ + + W P
Sbjct: 311 GHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQY-TEHLAAVKAIAWSPHQHG 369
Query: 206 ILATS--SQDNSVKFWDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQLRRENSL 263
+LA+ + D ++FW+ + L + V ++ +N LV+ +N +
Sbjct: 370 LLASGGGTADRCIRFWNTLTGQP-LQCIDTGSQVCNLAWSKHANELVST---HGYSQNQI 425
Query: 264 LLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDYQLVTWSRDQTLRMWRVDSQ 319
L+W L T V GH VL E +VT + D+TLR W V S+
Sbjct: 426 LVWKYPSL-TQVAKLTGHSYRVLYLAMSPDGEA-----IVTGAGDETLRFWNVFSK 475
Score = 42.7 bits (99), Expect = 0.002
Identities = 44/192 (22%), Positives = 77/192 (40%), Gaps = 21/192 (10%)
Query: 111 LDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVAGAS--QVKWNKKNANCLATSH 168
+DW+ +++ + T +Y+W ++ + +V G S V W+++ +H
Sbjct: 193 VDWSSLN---VLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTH 249
Query: 169 DGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRKYL 228
G V+IWD + L H +++ L W+ + L++ S+D + D R P
Sbjct: 250 KGFVQIWD-AAAGKKLSMLEGHTARVGALAWNAEQ---LSSGSRDRMILQRDIRTP---- 301
Query: 229 NILPCQVPVWKARYTPFSNGLVTVMVPQL----RRENSLLLWNVFDLNTPVHTFVGHDDV 284
P Q + GL QL +N LL+WN L +PV + H
Sbjct: 302 ---PLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSL-SPVQQYTEHLAA 357
Query: 285 VLEFQWRKQKEG 296
V W + G
Sbjct: 358 VKAIAWSPHQHG 369
>gi|209969678 Fzr1 protein isoform 3 [Homo sapiens]
Length = 404
Score = 57.0 bits (136), Expect = 8e-08
Identities = 57/236 (24%), Positives = 98/236 (41%), Gaps = 22/236 (9%)
Query: 90 WKDGSGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVA 149
W +G+ + L+GHT + L W + L + S D I DI+ P + +
Sbjct: 167 WDAAAGKKLSMLEGHTARVGALAW---NAEQLSSGSRDRMILQRDIRTP--PLQSERRLQ 221
Query: 150 GASQ----VKWNKKNANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEH 205
G Q +KW+ + + +D + +W+ S +Y HL+ + + W P
Sbjct: 222 GHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQY-TEHLAAVKAIAWSPHQHG 280
Query: 206 ILATS--SQDNSVKFWDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQLRRENSL 263
+LA+ + D ++FW+ + L + V ++ +N LV+ +N +
Sbjct: 281 LLASGGGTADRCIRFWNTLTGQP-LQCIDTGSQVCNLAWSKHANELVST---HGYSQNQI 336
Query: 264 LLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDYQLVTWSRDQTLRMWRVDSQ 319
L+W L T V GH VL E +VT + D+TLR W V S+
Sbjct: 337 LVWKYPSL-TQVAKLTGHSYRVLYLAMSPDGEA-----IVTGAGDETLRFWNVFSK 386
Score = 36.6 bits (83), Expect = 0.12
Identities = 36/149 (24%), Positives = 58/149 (38%), Gaps = 16/149 (10%)
Query: 152 SQVKWNKKNANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSS 211
+ V W+++ +H G V+IWD + L H +++ L W+ + L++ S
Sbjct: 144 TSVGWSERGNLVAVGTHKGFVQIWD-AAAGKKLSMLEGHTARVGALAWNAEQ---LSSGS 199
Query: 212 QDNSVKFWDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQL----RRENSLLLWN 267
+D + D R P P Q + GL QL +N LL+WN
Sbjct: 200 RDRMILQRDIRTP-------PLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 252
Query: 268 VFDLNTPVHTFVGHDDVVLEFQWRKQKEG 296
L +PV + H V W + G
Sbjct: 253 HSSL-SPVQQYTEHLAAVKAIAWSPHQHG 280
>gi|33620742 Fzr1 protein isoform 2 [Homo sapiens]
Length = 493
Score = 57.0 bits (136), Expect = 8e-08
Identities = 57/236 (24%), Positives = 98/236 (41%), Gaps = 22/236 (9%)
Query: 90 WKDGSGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVA 149
W +G+ + L+GHT + L W + L + S D I DI+ P + +
Sbjct: 256 WDAAAGKKLSMLEGHTARVGALAW---NAEQLSSGSRDRMILQRDIRTP--PLQSERRLQ 310
Query: 150 GASQ----VKWNKKNANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEH 205
G Q +KW+ + + +D + +W+ S +Y HL+ + + W P
Sbjct: 311 GHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQY-TEHLAAVKAIAWSPHQHG 369
Query: 206 ILATS--SQDNSVKFWDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQLRRENSL 263
+LA+ + D ++FW+ + L + V ++ +N LV+ +N +
Sbjct: 370 LLASGGGTADRCIRFWNTLTGQP-LQCIDTGSQVCNLAWSKHANELVST---HGYSQNQI 425
Query: 264 LLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDYQLVTWSRDQTLRMWRVDSQ 319
L+W L T V GH VL E +VT + D+TLR W V S+
Sbjct: 426 LVWKYPSL-TQVAKLTGHSYRVLYLAMSPDGEA-----IVTGAGDETLRFWNVFSK 475
Score = 42.7 bits (99), Expect = 0.002
Identities = 44/192 (22%), Positives = 77/192 (40%), Gaps = 21/192 (10%)
Query: 111 LDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVAGAS--QVKWNKKNANCLATSH 168
+DW+ +++ + T +Y+W ++ + +V G S V W+++ +H
Sbjct: 193 VDWSSLN---VLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTH 249
Query: 169 DGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRKYL 228
G V+IWD + L H +++ L W+ + L++ S+D + D R P
Sbjct: 250 KGFVQIWD-AAAGKKLSMLEGHTARVGALAWNAEQ---LSSGSRDRMILQRDIRTP---- 301
Query: 229 NILPCQVPVWKARYTPFSNGLVTVMVPQL----RRENSLLLWNVFDLNTPVHTFVGHDDV 284
P Q + GL QL +N LL+WN L +PV + H
Sbjct: 302 ---PLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSL-SPVQQYTEHLAA 357
Query: 285 VLEFQWRKQKEG 296
V W + G
Sbjct: 358 VKAIAWSPHQHG 369
>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
Length = 1336
Score = 56.6 bits (135), Expect = 1e-07
Identities = 60/269 (22%), Positives = 108/269 (40%), Gaps = 23/269 (8%)
Query: 52 RKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDL 111
R + + K + V+W P A+S + W + T LQ H + +
Sbjct: 112 RTSTNKVKCPVFVVRWTPEGRRLVTGASSG----EFTLWNGLTFNFETILQAHDSPVRAM 167
Query: 112 DWAVFEPDLLVTSSVDTYIYIW--DIKDTRKPTVALSAVAGASQVKWNKKNANCLATSHD 169
W+ + +L T+ Y+ W ++ + + A+ AS + K A C S D
Sbjct: 168 TWSHNDMWML-TADHGGYVKYWQSNMNNVKMFQAHKEAIREASFSPTDNKFATC---SDD 223
Query: 170 GDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNS--VKFWDYRQPRKY 227
G VRIWD + L H + + +DWHP ++ ++ + S+D+ +KFWD + +
Sbjct: 224 GTVRIWDFLR-CHEERILRGHGADVKCVDWHP-TKGLVVSGSKDSQQPIKFWDPKTGQSL 281
Query: 228 LNILPCQVPVWKARYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLE 287
+ + V + + N L+T R++ L+++ +L + F GH
Sbjct: 282 ATLHAHKNTVMEVKLNLNGNWLLTA-----SRDHLCKLFDIRNLKEELQVFRGHKKEATA 336
Query: 288 FQWRKQKEGSKDYQLVTWSRDQTLRMWRV 316
W EG + D +L W V
Sbjct: 337 VAWHPVHEG----LFASGGSDGSLLFWHV 361
Score = 54.7 bits (130), Expect = 4e-07
Identities = 48/188 (25%), Positives = 78/188 (41%), Gaps = 12/188 (6%)
Query: 53 KISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLD 112
+I R D+ V W+P + S Q + W +G+ TL H + ++
Sbjct: 238 RILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIKF--WDPKTGQSLATLHAHKNTVMEVK 295
Query: 113 WAVFEPDLLVTSSVDTYIYIWDIKDTRKPT-VALSAVAGASQVKWNKKNANCLATS-HDG 170
+ + L+T+S D ++DI++ ++ V A+ V W+ + A+ DG
Sbjct: 296 LNL-NGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDG 354
Query: 171 DVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQP------ 224
+ W AH I L WHP HIL + S D++ KFW +P
Sbjct: 355 SLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLG-HILCSGSNDHTSKFWTRNRPGDKMRD 413
Query: 225 RKYLNILP 232
R LN+LP
Sbjct: 414 RYNLNLLP 421
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 55.5 bits (132), Expect = 2e-07
Identities = 58/256 (22%), Positives = 102/256 (39%), Gaps = 20/256 (7%)
Query: 61 DIGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPDL 120
+I + +NP + A+ + W +GE TL+GH+ I L + D
Sbjct: 179 EIVCLSFNPQSTLV----ATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNT-SGDR 233
Query: 121 LVTSSVDTYIYIWDIKDTRKPTVALSAVAGASQVKWNKKNANCLATSHDGDVRIWDKRKP 180
++T S D + +WD RK + + A S +N + L S D ++WD
Sbjct: 234 IITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATN- 292
Query: 181 STAVEYLAAHLSKIHGLDWHPD-SEHILATSSQDNSVKFWDYRQPRKYLNILPCQVPVWK 239
V L H +I LD D + ++AT+S D + + + + + + + K
Sbjct: 293 GKCVATLTGHDDEI--LDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISK 350
Query: 240 ARYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKD 299
+ P N L+T + R +W+ + GH D + + K
Sbjct: 351 ISFNPQGNHLLTGSSDKTAR-----IWDA-QTGQCLQVLEGHTDEIFSCAFNY-----KG 399
Query: 300 YQLVTWSRDQTLRMWR 315
++T S+D T R+WR
Sbjct: 400 NIVITGSKDNTCRIWR 415
Score = 50.8 bits (120), Expect = 6e-06
Identities = 61/258 (23%), Positives = 105/258 (40%), Gaps = 23/258 (8%)
Query: 90 WKDGSGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVA 149
W SGE TL+GH V+ + + D + T S D +W ++ + A
Sbjct: 119 WDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTA 178
Query: 150 GASQVKWNKKNANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILAT 209
+ +N ++ S D ++WD + V L H ++I L ++ + I+ T
Sbjct: 179 EIVCLSFNPQSTLVATGSMDTTAKLWDIQN-GEEVYTLRGHSAEIISLSFNTSGDRII-T 236
Query: 210 SSQDNSVKFWDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQLRRENSLLLWNVF 269
S D++V WD RK ++ + A + + ++T + + + LW+
Sbjct: 237 GSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSM-----DKTCKLWDAT 291
Query: 270 DLNTPVHTFVGHDDVVLEFQWRKQKEGSKDYQ---LVTWSRDQTLRMWRVDSQMQRLCAN 326
+ V T GHDD +L + DY + T S D T R++ S R C
Sbjct: 292 N-GKCVATLTGHDDEIL--------DSCFDYTGKLIATASADGTARIF---SAATRKCIA 339
Query: 327 DILDGVDEFIESISLLPE 344
L+G + I IS P+
Sbjct: 340 K-LEGHEGEISKISFNPQ 356
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 55.1 bits (131), Expect = 3e-07
Identities = 45/184 (24%), Positives = 82/184 (44%), Gaps = 20/184 (10%)
Query: 49 EGHRKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVI 108
EGH++ R+ V W+P ++ +AS + ++K E TTL+GH +
Sbjct: 58 EGHQRTVRK-------VAWSPCGNYLA--SASFDATTCIWKKNQDDFECVTTLEGHENEV 108
Query: 109 SDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRK---PTVALSAVAGASQVKWNKKNANCLA 165
+ WA +LL T S D +++W++ + + +V S V W+ +
Sbjct: 109 KSVAWAP-SGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLAS 167
Query: 166 TSHDGDVRIWDKRKPS-TAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQP 224
S+D V+++ + + L H S + L + P + LA+ S D +V+ W
Sbjct: 168 ASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQR-LASCSDDRTVRIW----- 221
Query: 225 RKYL 228
R+YL
Sbjct: 222 RQYL 225
Score = 45.8 bits (107), Expect = 2e-04
Identities = 45/190 (23%), Positives = 71/190 (37%), Gaps = 31/190 (16%)
Query: 61 DIGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPD- 119
D+ V W+P +AS + V LY+ ++ TL+GH + L F+P
Sbjct: 152 DVKHVVWHPSQELLA--SASYDDTVKLYREEEDDWVCCATLEGHESTVWSL---AFDPSG 206
Query: 120 -LLVTSSVDTYIYIW--------------DIKDTRKPTVALSAVAGAS--QVKWNKKNAN 162
L + S D + IW + K LS + + W +
Sbjct: 207 QRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGA 266
Query: 163 CLATSHDGDVRIWDK---RKPSTAVEYLAAHLSKIHGLD-----WHPDSEHILATSSQDN 214
D +R++ + P L AHL + H D W+P +LA+ S D
Sbjct: 267 LATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDG 326
Query: 215 SVKFWDYRQP 224
V FW Y++P
Sbjct: 327 EVAFWKYQRP 336
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 54.3 bits (129), Expect = 5e-07
Identities = 44/196 (22%), Positives = 80/196 (40%), Gaps = 15/196 (7%)
Query: 57 QSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVF 116
Q K I A++WN +Y ++ + + W +GE H+ D+DW
Sbjct: 274 QHKGPIFALKWNKK---GNYVLSAGVDKTTII-WDAHTGEAKQQFPFHSAPALDVDWQ-- 327
Query: 117 EPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVAGASQVKWNKKNANCLATSHDGDVRIWD 176
+ S D I++ + + +KW+ + S D ++IW
Sbjct: 328 NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWS 387
Query: 177 KRKPSTAVEYLAAHLSKIHGLDW--------HPDSEHILATSSQDNSVKFWDYRQPRKYL 228
K V L AH +I+ + W +P+S +LA++S D++V+ WD Q
Sbjct: 388 M-KQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTH 446
Query: 229 NILPCQVPVWKARYTP 244
++ Q PV+ ++P
Sbjct: 447 TLMKHQEPVYSVAFSP 462
Score = 45.8 bits (107), Expect = 2e-04
Identities = 56/259 (21%), Positives = 93/259 (35%), Gaps = 45/259 (17%)
Query: 92 DGSGEV----GTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDT--------- 138
DG E+ T L+GH + W DLL + S D+ IW++ +
Sbjct: 162 DGDVEIPPNKATVLRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLV 220
Query: 139 -----RKPTVALSAVAGASQVKWNKKNANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSK 193
R+ + + + + WN S+DG RIW + L H
Sbjct: 221 LRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTEN--GNLASTLGQHKGP 278
Query: 194 IHGLDWHPDSEHILATSSQDNSVKFWDYR----QPRKYLNILPCQVPVWKARYTPFSNGL 249
I L W+ ++L ++ D + WD + + + P W+ T F++
Sbjct: 279 IFALKWNKKGNYVL-SAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMT-FASCS 336
Query: 250 VTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDYQLVTWSRDQ 309
+ + R + PV TF GH + V +W L + S D
Sbjct: 337 TDMCIHVCR----------LGCDHPVKTFQGHTNEVNAIKW-----DPSGMLLASCSDDM 381
Query: 310 TLRMWRVDSQMQRLCANDI 328
TL++W S Q C +D+
Sbjct: 382 TLKIW---SMKQDACVHDL 397
Score = 36.6 bits (83), Expect = 0.12
Identities = 35/131 (26%), Positives = 53/131 (40%), Gaps = 10/131 (7%)
Query: 49 EGHRKISRQSKWD-IGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRV 107
+ H K KW G NP+ S +AS + V L W G TL H
Sbjct: 398 QAHSKEIYTIKWSPTGPATSNPNSSIM-LASASFDSTVRL--WDVEQGVCTHTLMKHQEP 454
Query: 108 ISDLDWAVFEPD--LLVTSSVDTYIYIWDIKDTRKPTVALSAVAGASQVKWNKKNANCLA 165
+ + F PD L + S D Y++IW+ + + + G +V WN + A
Sbjct: 455 VYSV---AFSPDGKYLASGSFDKYVHIWNTQ-SGSLVHSYQGTGGIFEVCWNARGDKVGA 510
Query: 166 TSHDGDVRIWD 176
++ DG V + D
Sbjct: 511 SASDGSVCVLD 521
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,890,930
Number of Sequences: 37866
Number of extensions: 1972505
Number of successful extensions: 6602
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 79
Number of HSP's successfully gapped in prelim test: 181
Number of HSP's that attempted gapping in prelim test: 5599
Number of HSP's gapped (non-prelim): 851
length of query: 974
length of database: 18,247,518
effective HSP length: 112
effective length of query: 862
effective length of database: 14,006,526
effective search space: 12073625412
effective search space used: 12073625412
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.