Search of human proteins with 58219014

Search of human proteins with 58219014

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|58219014 solute carrier family 6, member 17 [Homo sapiens]
         (727 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|58219014 solute carrier family 6, member 17 [Homo sapiens]        1469   0.0  
gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo s...  1006   0.0  
gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo ...   877   0.0  
gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo s...   513   e-145
gi|51468073 solute carrier family 6, member 19 [Homo sapiens]         512   e-145
gi|194018524 solute carrier family 6, member 18 [Homo sapiens]        501   e-141
gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo s...   450   e-126
gi|55749589 solute carrier family 6, member 16 [Homo sapiens]         448   e-126
gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo s...   378   e-104
gi|134304856 solute carrier family 6, member 7 [Homo sapiens]         358   7e-99
gi|6005715 solute carrier family 6 (amino acid transporter), mem...   342   9e-94
gi|188528618 solute carrier family 6 (neurotransmitter transport...   330   2e-90
gi|92859670 solute carrier family 6 (neurotransmitter transporte...   313   3e-85
gi|4507043 solute carrier family 6 member 4 [Homo sapiens]            303   4e-82
gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo sap...   300   4e-81
gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo sap...   299   5e-81
gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo sap...   298   9e-81
gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo sapi...   292   7e-79
gi|171184408 solute carrier family 6 (neurotransmitter transport...   289   6e-78
gi|171184406 solute carrier family 6 (neurotransmitter transport...   289   6e-78
gi|171184404 solute carrier family 6 (neurotransmitter transport...   289   6e-78
gi|21361581 solute carrier family 6 (neurotransmitter transporte...   283   4e-76
gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo sa...   277   3e-74
gi|4557046 solute carrier family 6 member 2 [Homo sapiens]            276   6e-74
gi|197276623 solute carrier family 6 (neurotransmitter transport...   275   1e-73
gi|54607094 solute carrier family 6 (neurotransmitter transporte...   275   1e-73
gi|7657587 solute carrier family 6 (neurotransmitter transporter...   274   2e-73
gi|4507041 solute carrier family 6 (neurotransmitter transporter...   273   3e-73
gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo sa...   205   1e-52
gi|197276625 solute carrier family 6 (neurotransmitter transport...   152   8e-37

>gi|58219014 solute carrier family 6, member 17 [Homo sapiens]
          Length = 727

 Score = 1469 bits (3803), Expect = 0.0
 Identities = 727/727 (100%), Positives = 727/727 (100%)

Query: 1   MPKNSKVTQREHSSEHVTESVADLLALEEPVDYKQSVLNVAGEAGGKQKAVEEELDAEDR 60
           MPKNSKVTQREHSSEHVTESVADLLALEEPVDYKQSVLNVAGEAGGKQKAVEEELDAEDR
Sbjct: 1   MPKNSKVTQREHSSEHVTESVADLLALEEPVDYKQSVLNVAGEAGGKQKAVEEELDAEDR 60

Query: 61  PAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAV 120
           PAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAV
Sbjct: 61  PAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAV 120

Query: 121 GQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWSE 180
           GQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWSE
Sbjct: 121 GQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWSE 180

Query: 181 CPVVRNGSVAVVEAECEKSSATTYFWYREALDISDSISESGGLNWKMTLCLLVAWSIVGM 240
           CPVVRNGSVAVVEAECEKSSATTYFWYREALDISDSISESGGLNWKMTLCLLVAWSIVGM
Sbjct: 181 CPVVRNGSVAVVEAECEKSSATTYFWYREALDISDSISESGGLNWKMTLCLLVAWSIVGM 240

Query: 241 AVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWRE 300
           AVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWRE
Sbjct: 241 AVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWRE 300

Query: 301 AATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKAN 360
           AATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKAN
Sbjct: 301 AATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKAN 360

Query: 361 IMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQFSAL 420
           IMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQFSAL
Sbjct: 361 IMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQFSAL 420

Query: 421 GLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAG 480
           GLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAG
Sbjct: 421 GLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAG 480

Query: 481 ITTPIIDTFKVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILEN 540
           ITTPIIDTFKVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILEN
Sbjct: 481 ITTPIIDTFKVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILEN 540

Query: 541 IAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSA 600
           IAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSA
Sbjct: 541 IAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSA 600

Query: 601 WIKEEAAERYLYFPNWAMALLITLIVVATLPIPVVFVLRHFHLLSDGSNTLSVSYKKGRM 660
           WIKEEAAERYLYFPNWAMALLITLIVVATLPIPVVFVLRHFHLLSDGSNTLSVSYKKGRM
Sbjct: 601 WIKEEAAERYLYFPNWAMALLITLIVVATLPIPVVFVLRHFHLLSDGSNTLSVSYKKGRM 660

Query: 661 MKDISNLEENDETRFILSKVPSEAPSPMPTHRSYLGPGSTSPLETSGNPNGRYGSGYLLA 720
           MKDISNLEENDETRFILSKVPSEAPSPMPTHRSYLGPGSTSPLETSGNPNGRYGSGYLLA
Sbjct: 661 MKDISNLEENDETRFILSKVPSEAPSPMPTHRSYLGPGSTSPLETSGNPNGRYGSGYLLA 720

Query: 721 STPESEL 727
           STPESEL
Sbjct: 721 STPESEL 727


>gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo
           sapiens]
          Length = 730

 Score = 1006 bits (2600), Expect = 0.0
 Identities = 487/735 (66%), Positives = 603/735 (82%), Gaps = 13/735 (1%)

Query: 1   MPKNSKVTQREHSSEHVTESVADLLALEEPVD--YKQSVLNVAGEAGGKQKAVEEELDAE 58
           MPKNSKV +RE   + VTESV DLL+ E+  D  +K S L V G+   K   VEE  + E
Sbjct: 1   MPKNSKVVKRELDDD-VTESVKDLLSNEDAADDAFKTSELIVDGQEE-KDTDVEEGSEVE 58

Query: 59  D-RPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLE 117
           D RPAWNSKLQYILAQ+GFSVGLGN+WRFPYLCQKNGGGAYL+PYL+LL++IGIPLFFLE
Sbjct: 59  DERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLE 118

Query: 118 LAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLP 177
           L+VGQRIRRGSIGVW+YI P+LGGIGF+SC+VC FV LYYNVIIGWS+FYF +SFQ PLP
Sbjct: 119 LSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLP 178

Query: 178 WSECPVVRNGSVAVVEAECEKSSATTYFWYREALDISDSISESGGLNWKMTLCLLVAWSI 237
           W +CP+V+N S   VE ECE+SSATTY+WYREAL+IS SISESGGLNWKMT+CLL AW +
Sbjct: 179 WDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAAWVM 238

Query: 238 VGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQV 297
           V +A++KGIQSSGK++YFSSLFPYVVL CFL+R  LL G++DGI HMFTPKL+ ML+P+V
Sbjct: 239 VCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKV 298

Query: 298 WREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGF 357
           WREAATQVFFALGLGFGGVIAFSSYNK+DNNCHFDA LVSFINFFTSVLATLVVFAVLGF
Sbjct: 299 WREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGF 358

Query: 358 KANIMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQF 417
           KAN++NEKC+ +N+E I+ +L    +S+D+IP H+N S +T +DY  +Y++I  VKE++F
Sbjct: 359 KANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVYDIIQKVKEEEF 418

Query: 418 SALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGT 477
            AL L+ C +E+EL+K+VQGTGLAFIAFTEAMTHFPASPFWSVMFFLML+NLGLGSM GT
Sbjct: 419 PALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGT 478

Query: 478 MAGITTPIIDTFKVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVI 537
           + GI TPI+DTFKV KE+ TV CC+ AF +GL+FVQRSGNYFVTMFDDYSATLPL ++VI
Sbjct: 479 IEGIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVI 538

Query: 538 LENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPG 597
           LENIAV ++YG  KFM++L +MLGF P R+Y+YMWK++SPL +  L  AS++ +G++PPG
Sbjct: 539 LENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPG 598

Query: 598 YSAWIKEEAAERYLYFPNWAMALLITLIVVATLPIPVVFVLRHFHLLSDGS-NTLSVSYK 656
           Y+AWI+++A+E +L +P W + + ++L+V A LP+PVVF++R F+L+ D S N  SV+YK
Sbjct: 599 YNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLIDDSSGNLASVTYK 658

Query: 657 KGRMMKDISNLEENDETRFILSKVPSEAPSPMPTHRSYLGPGSTSPLETSGNPNGRYGSG 716
           +GR++K+  NL E D+T  I  K+PSE PSP      Y     +  L+T+  PNGRYG G
Sbjct: 659 RGRVLKEPVNL-EGDDTSLIHGKIPSEMPSPNFGKNIYRKQSGSPTLDTA--PNGRYGIG 715

Query: 717 YLLA----STPESEL 727
           YL+A      PES+L
Sbjct: 716 YLMADIMPDMPESDL 730


>gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo
           sapiens]
          Length = 623

 Score =  877 bits (2265), Expect = 0.0
 Identities = 414/626 (66%), Positives = 519/626 (82%), Gaps = 8/626 (1%)

Query: 107 IIIGIPLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIF 166
           ++IGIPLFFLEL+VGQRIRRGSIGVW+YI P+LGGIGF+SC+VC FV LYYNVIIGWS+F
Sbjct: 1   MVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLF 60

Query: 167 YFFKSFQYPLPWSECPVVRNGSVAVVEAECEKSSATTYFWYREALDISDSISESGGLNWK 226
           YF +SFQ PLPW +CP+V+N S   VE ECE+SSATTY+WYREAL+IS SISESGGLNWK
Sbjct: 61  YFSQSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWK 120

Query: 227 MTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFT 286
           MT+CLL AW +V +A++KGIQSSGK++YFSSLFPYVVL CFL+R  LL G++DGI HMFT
Sbjct: 121 MTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFT 180

Query: 287 PKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVL 346
           PKL+ ML+P+VWREAATQVFFALGLGFGGVIAFSSYNK+DNNCHFDA LVSFINFFTSVL
Sbjct: 181 PKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVL 240

Query: 347 ATLVVFAVLGFKANIMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMY 406
           ATLVVFAVLGFKAN++NEKC+ +N+E I+ +L    +S+D+IP H+N S +T +DY  +Y
Sbjct: 241 ATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVY 300

Query: 407 NVIMTVKEDQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLML 466
           ++I  VKE++F AL L+ C +E+EL+K+VQGTGLAFIAFTEAMTHFPASPFWSVMFFLML
Sbjct: 301 DIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLML 360

Query: 467 INLGLGSMIGTMAGITTPIIDTFKVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDY 526
           +NLGLGSM GT+ GI TPI+DTFKV KE+ TV CC+ AF +GL+FVQRSGNYFVTMFDDY
Sbjct: 361 VNLGLGSMFGTIEGIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDY 420

Query: 527 SATLPLTLIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTA 586
           SATLPL ++VILENIAV ++YG  KFM++L +MLGF P R+Y+YMWK++SPL +  L  A
Sbjct: 421 SATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIA 480

Query: 587 SIIQLGVTPPGYSAWIKEEAAERYLYFPNWAMALLITLIVVATLPIPVVFVLRHFHLLSD 646
           S++ +G++PPGY+AWI+++A+E +L +P W + + ++L+V A LP+PVVF++R F+L+ D
Sbjct: 481 SVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLIDD 540

Query: 647 GS-NTLSVSYKKGRMMKDISNLEENDETRFILSKVPSEAPSPMPTHRSYLGPGSTSPLET 705
            S N  SV+YK+GR++K+  NL E D+T  I  K+PSE PSP      Y     +  L+T
Sbjct: 541 SSGNLASVTYKRGRVLKEPVNL-EGDDTSLIHGKIPSEMPSPNFGKNIYRKQSGSPTLDT 599

Query: 706 SGNPNGRYGSGYLLA----STPESEL 727
           +  PNGRYG GYL+A      PES+L
Sbjct: 600 A--PNGRYGIGYLMADIMPDMPESDL 623


>gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo
           sapiens]
          Length = 592

 Score =  513 bits (1320), Expect = e-145
 Identities = 254/582 (43%), Positives = 378/582 (64%), Gaps = 21/582 (3%)

Query: 60  RPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELA 119
           RP W + LQ++ A I ++VGLGN+WRFPYLCQ  GGG++LVPY+++LI+ G+PL +LELA
Sbjct: 5   RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64

Query: 120 VGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWS 179
           VGQR+R+GSIG W  I P L G+G +S +V  F+ +YYNVI  W+ +Y F SFQ PLPWS
Sbjct: 65  VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124

Query: 180 ECPVVRNGSVAVVEAECEKSSATTYFWYREALDISDSISESGGLNWKMTLCLLVAWSIVG 239
            CP+  NG+    + ECEK+S+T YFWYR+ L+IS S+ E+GG+ W+  LCLL+AW +V 
Sbjct: 125 VCPL--NGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVY 182

Query: 240 MAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWR 299
           + +++G +S+GKV+YF++  PY VL  +L+RGL L GA +G+++MFTPK++++ +P+ W 
Sbjct: 183 LCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQLANPKAWI 242

Query: 300 EAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKA 359
            AATQ+FF+LGLGFG +IAF+SYN+  NNC   A +VS IN FTS+ A++V F++ GFKA
Sbjct: 243 NAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKA 302

Query: 360 NIMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQFSA 419
               E C+     K +  L TN          +    LT  +  ++   + +    ++S 
Sbjct: 303 TFNYENCL-----KKVSLLLTNTFD-------LEDGFLTASNLEQVKGYLASAYPSKYSE 350

Query: 420 L--GLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGT 477
           +   +  C LE ELD +VQGTGLAFI +TEA+ +   S  WSV++F ML+ LG+GSM+G 
Sbjct: 351 MFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGN 410

Query: 478 MAGITTPIID----TFKVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLT 533
            A I TP+ D    +  +PKE  +   C+    +G++F   +GNY+  +F+DY+ATL L 
Sbjct: 411 TAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLL 470

Query: 534 LIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGV 593
           LIV++E IAV ++YG ++F  +L  M G     ++  MW  VSPL +  L    +    +
Sbjct: 471 LIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYIL 530

Query: 594 TPP-GYSAWIKEEAAERYLYFPNWAMALLITLIVVATLPIPV 634
           T    Y AW   +       +P +A+A++  L+  +T+ IP+
Sbjct: 531 TGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPL 572


>gi|51468073 solute carrier family 6, member 19 [Homo sapiens]
          Length = 634

 Score =  512 bits (1319), Expect = e-145
 Identities = 258/615 (41%), Positives = 376/615 (61%), Gaps = 31/615 (5%)

Query: 53  EELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIP 112
           E+ +A  RP W++K QY+L  +GF VGLGN+WRFPYLCQ +GGGA+++P+L+LL++ GIP
Sbjct: 25  EQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIP 84

Query: 113 LFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSF 172
           L +LE A+GQR+RRGS+GVW  I P L G+G +S +    VGLYYN II W ++Y F SF
Sbjct: 85  LLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSF 144

Query: 173 QYPLPWSECPVVRNGSVAVVEAECEKSSATTYFWYREALDISDSISESGGLNWKMTLCLL 232
           Q PLPWS+CP+  N +  V   EC +SS   YFWYRE L+IS SIS+SG + W M LCL 
Sbjct: 145 QEPLPWSDCPLNENQTGYV--DECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLA 202

Query: 233 VAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKM 292
            AWS++ M  ++GI+++GK +Y +S  PYVVL  FL+RGL L+GA +GI+ +FTP + ++
Sbjct: 203 CAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTEL 262

Query: 293 LDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVF 352
             P  W +A  QVFF+  L FGG+I+FSSYN   NNC  D+ +VS IN FTSV   +VV+
Sbjct: 263 AQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVY 322

Query: 353 AVLGFKANIMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTV 412
           +V+GF+A    + C   N   IL  +N   L            ++T +++++M       
Sbjct: 323 SVIGFRATQRYDDCFSTN---ILTLINGFDLPE---------GNVTQENFVDMQQRCNAS 370

Query: 413 KEDQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLG 472
               ++ L    C +   L ++V+GTGLAFI FTEA+T  P SP WSV+FF+ML  LGL 
Sbjct: 371 DPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLS 430

Query: 473 SMIGTMAGITTPIIDTF----KVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSA 528
           SM G M G+  P+ D      K PKE+ T   C+  FL+G +F   SG Y++++ D Y+ 
Sbjct: 431 SMFGNMEGVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAG 490

Query: 529 TLPLTLIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMA------- 581
           ++PL +I   E  +V ++YG  +F +++  M+G +P  F+   W+ VSPL M        
Sbjct: 491 SIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFF 550

Query: 582 VLTTASIIQLGVTPPGYSAWIKEEAAERYLYFPNWAMALLITLIVVATLPIP--VVFVLR 639
           V+  +  +   +  PGY  + K +     + +PNW   +++ +  V +L IP   ++ L 
Sbjct: 551 VVEVSQELTYSIWDPGYEEFPKSQK----ISYPNWVYVVVVIVAGVPSLTIPGYAIYKLI 606

Query: 640 HFHLLSDGSNTLSVS 654
             H    G +   VS
Sbjct: 607 RNHCQKPGDHQGLVS 621


>gi|194018524 solute carrier family 6, member 18 [Homo sapiens]
          Length = 628

 Score =  501 bits (1289), Expect = e-141
 Identities = 250/584 (42%), Positives = 367/584 (62%), Gaps = 22/584 (3%)

Query: 58  EDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLE 117
           ++RP W++K QY+L+  GF+VGLGNIWRFPYLCQ  GGGA+L+PY++ L+  GIP+F +E
Sbjct: 16  DERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVE 75

Query: 118 LAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLP 177
           LA+GQR+R+GS+GVW  I P L G+G     +   + LYYN I+ W ++Y   SFQ+PLP
Sbjct: 76  LAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLP 135

Query: 178 WSECPVVRNGSVAVVEAECEKSSATTYFWYREALDISDSISESGGLNWKMTLCLLVAWSI 237
           WS CP   N +  V   EC+ SSA +YFWYR+ L+I+  I++SG + W + +CL  +W++
Sbjct: 136 WSSCPPDLNRTGFV--EECQGSSAVSYFWYRQTLNITADINDSGSIQWWLLICLAASWAV 193

Query: 238 VGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQV 297
           V M V++GI+++GKV+YF++LFPY+VL  FL+RGL L GA  G++++FTP +  + +P+V
Sbjct: 194 VYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNMHILQNPRV 253

Query: 298 WREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGF 357
           W +AATQ+FF+L L FGG IAF+SYN   N+C  DA +++ +N  TS+ A++ VF+VLGF
Sbjct: 254 WLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASIAVFSVLGF 313

Query: 358 KANIMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQF 417
           KA    E C+  N   IL  +N      D   P  + S     DY  +   +      + 
Sbjct: 314 KATNDYEHCLDRN---ILSLIN------DFDFPEQSISR---DDYPAVLMHLNATWPKRV 361

Query: 418 SALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGT 477
           + L L  CLLED LDKS  G GLAF+ FTE   H P +P W+++FF ML  LGL +M GT
Sbjct: 362 AQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGT 421

Query: 478 MAGITTPIIDTFK----VPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLT 533
           +  + TP++D       VPKE  T   C+  FL    F  +SGNY++ +FD+++A+  L 
Sbjct: 422 VEAVITPLLDVGVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASPNLL 481

Query: 534 LIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGV 593
           ++  LE + V ++YG K+F  ++  M G RP  ++   W+ VSPL + +   A II L  
Sbjct: 482 MLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLLTIF-VAYIILLFW 540

Query: 594 TPPGYSAWIKEE---AAERYLYFPNWAMALLITLIVVATLPIPV 634
            P  Y AW  +     + +   +P WA A  + L ++  L +PV
Sbjct: 541 KPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPV 584


>gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo
           sapiens]
          Length = 555

 Score =  450 bits (1157), Expect = e-126
 Identities = 234/582 (40%), Positives = 349/582 (59%), Gaps = 58/582 (9%)

Query: 60  RPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELA 119
           RP W + LQ++ A I ++VGLGN+WRFPYLCQ  GGG++LVPY+++LI+ G+PL +LELA
Sbjct: 5   RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64

Query: 120 VGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWS 179
           VGQR+R+GSIG W  I P L G+G +S +V  F+ +YYNVI  W+ +Y F SFQ PLPWS
Sbjct: 65  VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124

Query: 180 ECPVVRNGSVAVVEAECEKSSATTYFWYREALDISDSISESGGLNWKMTLCLLVAWSIVG 239
            CP+  NG+    + ECEK+S+T YFWYR+ L+IS S+ E+GG+ W+  LCLL+AW +V 
Sbjct: 125 VCPL--NGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVY 182

Query: 240 MAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWR 299
           + +++G +S+GK+                                     +++ +P+ W 
Sbjct: 183 LCILRGTESTGKI-------------------------------------EQLANPKAWI 205

Query: 300 EAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKA 359
            AATQ+FF+LGLGFG +IAF+SYN+  NNC   A +VS IN FTS+ A++V F++ GFKA
Sbjct: 206 NAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKA 265

Query: 360 NIMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQFSA 419
               E C+     K +  L TN          +    LT  +  ++   + +    ++S 
Sbjct: 266 TFNYENCL-----KKVSLLLTNTFD-------LEDGFLTASNLEQVKGYLASAYPSKYSE 313

Query: 420 L--GLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGT 477
           +   +  C LE ELD +VQGTGLAFI +TEA+ +   S  WSV++F ML+ LG+GSM+G 
Sbjct: 314 MFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGN 373

Query: 478 MAGITTPIID----TFKVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLT 533
            A I TP+ D    +  +PKE  +   C+    +G++F   +GNY+  +F+DY+ATL L 
Sbjct: 374 TAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLL 433

Query: 534 LIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGV 593
           LIV++E IAV ++YG ++F  +L  M G     ++  MW  VSPL +  L    +    +
Sbjct: 434 LIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYIL 493

Query: 594 TPP-GYSAWIKEEAAERYLYFPNWAMALLITLIVVATLPIPV 634
           T    Y AW   +       +P +A+A++  L+  +T+ IP+
Sbjct: 494 TGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPL 535


>gi|55749589 solute carrier family 6, member 16 [Homo sapiens]
          Length = 736

 Score =  448 bits (1152), Expect = e-126
 Identities = 237/668 (35%), Positives = 368/668 (55%), Gaps = 28/668 (4%)

Query: 36  SVLNVAGEAGGKQKAVEEELDAED---------RPAWNSKLQYILAQIGFSVGLGNIWRF 86
           SVL     +   QK   E++   +         RP W+SK +YILAQ+GFS+    +WRF
Sbjct: 70  SVLEALTASALNQKPTHEKVQMTEKKESEVLLARPFWSSKTEYILAQVGFSMKPSCLWRF 129

Query: 87  PYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSS 146
            YL   +GG ++   Y+ +L ++G+PL FLE+A GQ +R+G +GVW  I P +GG+G+SS
Sbjct: 130 AYLWLNSGGCSFAAIYIFMLFLVGVPLLFLEMAAGQSMRQGGMGVWKIIAPWIGGVGYSS 189

Query: 147 CIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWSECPVVRNGSVAVVEAECEKSSATTYFW 206
            +VC  +GLY+NV+  W IFY  +SFQ+P+PW +CP+  N S    + ECE+++ + YFW
Sbjct: 190 FMVCFILGLYFNVVNSWIIFYMSQSFQFPVPWEKCPLTMNSS--GFDPECERTTPSIYFW 247

Query: 207 YREALDISDSISESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLAC 266
           Y++AL  SD I + G   + + L   + W +VG  ++ G++S+GKV+Y   L P  ++  
Sbjct: 248 YQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLLPCFIIVG 307

Query: 267 FLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQD 326
           F +R LLL GA  G+  +   K+  + +  VW  A  QV    G+G G V + +SY  Q 
Sbjct: 308 FFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASLASYMPQS 367

Query: 327 NNCHFDAALVSFINFFTSVLATLVVFAVLGFKANIMNEKCVVENAEKILGYLNTNVLSRD 386
           NNC  DA LVS IN  T ++ T   F VLGF A ++  +C   NAE +L  +N   L  D
Sbjct: 368 NNCLSDAFLVSVINLLTLLVFTSFNFCVLGFWATVITHRCCERNAEILLKLINLGKLPPD 427

Query: 387 LIPPHVNFSHLTTKDYMEMYNVIMTVKEDQFSALGL---DPCLLEDELDKSVQGTGLAFI 443
             PP VN  +  T     +YN  ++       ++ L     C +E +  K+ +G   AF+
Sbjct: 428 AKPP-VNLLYNPT----SIYNAWLSGLPQHIKSMVLREVTECNIETQFLKASEGPKFAFL 482

Query: 444 AFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDT---FKVPKEMFTVGC 500
           +F EAM+  P S FWS +FFLML+ +GL S IG M GI TP+ DT   F+   ++  VG 
Sbjct: 483 SFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGIITPLQDTFSFFRKHTKLLIVGV 542

Query: 501 CVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILENIAVAWIYGTKKFMQELTEML 560
            +  F+ GL F + SG+YF+ +  DY    P+ ++V+ E +AV+W YG ++F+ +LT +L
Sbjct: 543 FLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIVVVVFETMAVSWAYGARRFLADLTILL 602

Query: 561 GFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSAWIKEEAAERYLYFPNWAMAL 620
           G      + ++W  + P+ + ++    ++ L + P  Y +W    + E    +P WA+ L
Sbjct: 603 GHPISPIFGWLWPHLCPVVLLIIFVTMMVHLCMKPITYMSWDSSTSKEVLRPYPPWALLL 662

Query: 621 LITLIVVATLPIPVVFVLRHFHLL------SDGSNTLSVSYKKGRMMKDISNLEENDETR 674
           +ITL  +  LPIP  FV    H +       DG  T S S      +     +++ +  +
Sbjct: 663 MITLFAIVILPIPAYFVYCRIHRIPFRPKSGDGPMTASTSLPLSHQLTPSKEVQKEEILQ 722

Query: 675 FILSKVPS 682
              +K PS
Sbjct: 723 VDETKYPS 730


>gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo
           sapiens]
          Length = 289

 Score =  378 bits (970), Expect = e-104
 Identities = 188/267 (70%), Positives = 222/267 (83%), Gaps = 8/267 (2%)

Query: 1   MPKNSKVTQREHSSEHVTESVADLLALEEPVD--YKQSVLNVAGEAGGKQKAVEEELDAE 58
           MPKNSKV +RE   + VTESV DLL+ E+  D  +K S L V G+   K   VEE  + E
Sbjct: 1   MPKNSKVVKRELDDD-VTESVKDLLSNEDAADDAFKTSELIVDGQEE-KDTDVEEGSEVE 58

Query: 59  D-RPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLE 117
           D RPAWNSKLQYILAQ+GFSVGLGN+WRFPYLCQKNGGGAYL+PYL+LL++IGIPLFFLE
Sbjct: 59  DERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLE 118

Query: 118 LAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLP 177
           L+VGQRIRRGSIGVW+YI P+LGGIGF+SC+VC FV LYYNVIIGWS+FYF +SFQ PLP
Sbjct: 119 LSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLP 178

Query: 178 WSECPVVRNGSVAVVEAECEKSSATTYFWYREALDISDSISESGGLNWKMTLCLLVAWSI 237
           W +CP+V+N S   VE ECE+SSATTY+WYREAL+IS SISESGGLNWKMT+CLL AW +
Sbjct: 179 WDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAAWVM 238

Query: 238 VGMAVVKGIQSSGKVMYFSSLFPYVVL 264
           V +A++KGIQSSGKV   S L P+++L
Sbjct: 239 VCLAMIKGIQSSGKV---SMLEPFLIL 262


>gi|134304856 solute carrier family 6, member 7 [Homo sapiens]
          Length = 636

 Score =  358 bits (920), Expect = 7e-99
 Identities = 234/673 (34%), Positives = 346/673 (51%), Gaps = 107/673 (15%)

Query: 48  QKAVEEELD-AEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLL 106
           Q  V+ ++D A  R  W  KL ++L+ IG+ VGLGN+WRFPY    NGGGA+LVPY ++L
Sbjct: 24  QGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLML 83

Query: 107 IIIGIPLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIF 166
            I GIPLFFLEL++GQ    G + VW  I P   G G +  ++   V +YYN+II + +F
Sbjct: 84  AICGIPLFFLELSLGQFSSLGPLAVWK-ISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLF 142

Query: 167 YFFKSFQYPLPWSECP------------VVRNGSVAV-VEAECEKSSATTYFWYREALDI 213
           Y F S    LPW  C             V ++G+ A+ +   C  S +  Y W R  L I
Sbjct: 143 YLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEY-WSRYVLHI 201

Query: 214 --SDSISESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRG 271
             S  I   G + W + LCLL+AW IV + ++KG++SSGKV+YF++ FPY++L   LVRG
Sbjct: 202 QGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRG 261

Query: 272 LLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHF 331
           + L GA  GI    TP+   +L  +VW EAA Q+F++LG+GFGG++ F+SYN    N + 
Sbjct: 262 VTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYR 321

Query: 332 DAALVSFINFFTSVLATLVVFAVLGFKANIMNEKCVVENAEKILGYLNTNVLSRDLIPPH 391
           D  +V+  N  TS+   L  FA+                   +LGY+     S++L  P 
Sbjct: 322 DTFIVTLGNAITSI---LAGFAIFS-----------------VLGYM-----SQELGVP- 355

Query: 392 VNFSHLTTKDYMEMYNVIMTVKEDQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTH 451
                                                D++ K+  G GLAF+ + +AMT 
Sbjct: 356 ------------------------------------VDQVAKA--GPGLAFVVYPQAMTM 377

Query: 452 FPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTF----KVPKEMFTVGCCVFAFLV 507
            P SPFWS +FF ML+ LGL S    +  I T + D F    +  K +F+   CV  +L+
Sbjct: 378 LPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLM 437

Query: 508 GLLFVQRSGNYFVTMFDDYSATLPLTLIVILENIAVAWIYGTKKFMQELTEMLGFRPYRF 567
           GL+     G Y++ + DDYSA+  L ++VI   +AV  +YG ++F +++  MLGF+P  +
Sbjct: 438 GLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLY 497

Query: 568 YFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSAWIKEEAAERYLYFPNWAMALLITLIVV 627
           +   W F+SP  +  L   SI++    P  Y ++           FP WA  L I + ++
Sbjct: 498 FRACWLFLSPATLLALMVYSIVK--YQPSEYGSY----------RFPPWAELLGILMGLL 545

Query: 628 ATLPIP---VVFVLRHFHLLSDGSNTLSVSYKKGRMMKDISNLEENDETRFILSKVPSEA 684
           + L IP   +V VLR      +GS    +       M    +LEEN    ++ +   S++
Sbjct: 546 SCLMIPAGMLVAVLR-----EEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQS 600

Query: 685 PSPMPTH-RSYLG 696
           P P+  H R Y G
Sbjct: 601 PKPLMVHMRKYGG 613


>gi|6005715 solute carrier family 6 (amino acid transporter), member
           14 [Homo sapiens]
          Length = 642

 Score =  342 bits (876), Expect = 9e-94
 Identities = 203/635 (31%), Positives = 328/635 (51%), Gaps = 123/635 (19%)

Query: 51  VEEELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIG 110
           V E  + +DR  W+ K  Y+L+ IG++VGLGN+WRFPYL   NGGGA+L+PY ++L + G
Sbjct: 27  VGENDENQDRGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAG 86

Query: 111 IPLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFK 170
           +PLFFLE ++GQ    G + VW  I P   G+G +  ++ +FV +YYNVII +S++Y F 
Sbjct: 87  LPLFFLECSLGQFASLGPVSVWR-ILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFA 145

Query: 171 SFQYPLPWSEC-----------PVVRNGSVAVVEAECEK--------------------- 198
           SFQ  LPW  C           P+V + +V+ V    ++                     
Sbjct: 146 SFQSELPWKNCSSWSDKNCSRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSE 205

Query: 199 -----SSATTYFWYREALDISDSISESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVM 253
                   +  +W + AL  S  ++E+G + W + LCLL+AW IVG A+ KGI+SSGKV+
Sbjct: 206 IYQPGQLPSEQYWNKVALQRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVV 265

Query: 254 YFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLD--KMLDPQVWREAATQVFFALGL 311
           YF++LFPYVVL   LVRG  L GA  GI +    + +  K+ + +VW++AATQ+F++L +
Sbjct: 266 YFTALFPYVVLLILLVRGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSV 325

Query: 312 GFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKANIMNEKCVVENA 371
            +GG++                AL S+  F  +  +  +V  +     ++     +    
Sbjct: 326 AWGGLV----------------ALSSYNKFKNNCFSDAIVVCLTNCLTSVFAGFAIFS-- 367

Query: 372 EKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQFSALGLDPCLLEDEL 431
             ILG++                +H++ K+  ++                          
Sbjct: 368 --ILGHM----------------AHISGKEVSQVVK------------------------ 385

Query: 432 DKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTF-K 490
                G  LAFIA+ EA+   P  PFWS++FF ML+ LGL S   ++  ITT I D F K
Sbjct: 386 ----SGFDLAFIAYPEALAQLPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFPK 441

Query: 491 VPKEM---FTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILENIAVAWIY 547
           V K+M    T+GCC+  FL+GL+ V ++G Y+V + D + A   + +  ILE + + WIY
Sbjct: 442 VMKKMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHFCAGWGILIAAILELVGIIWIY 501

Query: 548 GTKKFMQELTEMLGFRPYRFYFY---MWKFVSPLCMAVLTTASIIQLGVTPPGYSAWIKE 604
           G  +F+++   M+G + + F+ +    W  ++P+ +  +   S++Q     P Y A    
Sbjct: 502 GGNRFIEDTEMMIGAKRWIFWLWWRACWFVITPILLIAIFIWSLVQF--HRPNYGA---- 555

Query: 605 EAAERYLYFPNWAMALLITLIVVATLPIPVVFVLR 639
                 + +P+W +AL   +IV   + IP++ +++
Sbjct: 556 ------IPYPDWGVALGWCMIVFCIIWIPIMAIIK 584


>gi|188528618 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 1 [Homo sapiens]
          Length = 599

 Score =  330 bits (847), Expect = 2e-90
 Identities = 180/595 (30%), Positives = 302/595 (50%), Gaps = 90/595 (15%)

Query: 49  KAVEEELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLII 108
           K  ++  D  DR  W  +  ++++ +G+++GLGN+WRFPYLC KNGGGA+L+PY + LI 
Sbjct: 33  KVQKKAADLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIF 92

Query: 109 IGIPLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYF 168
            G+PLF LE ++GQ    G +GVW  + P   G+G ++ ++  ++ +YY VII W+I+Y 
Sbjct: 93  AGVPLFLLECSLGQYTSIGGLGVWK-LAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYL 151

Query: 169 FKSFQYPLPWSECPVVRN-----GSVAVVEAECEKSSATTYFWYREALDISDSISESGGL 223
           + SF   LPW +C    N      + ++V      +SA   FW R    ++D + + G +
Sbjct: 152 YNSFTTTLPWKQCDNPWNTDRCFSNYSMVNTT-NMTSAVVEFWERNMHQMTDGLDKPGQI 210

Query: 224 NWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILH 283
            W + + L +AW +V   + KG+  +GKV+YFS+ +PY++L     RG+ L GA +GIL 
Sbjct: 211 RWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILF 270

Query: 284 MFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFT 343
             TP   K+ D +VW +AATQ+FF+ GLG G +I                AL S+ +F  
Sbjct: 271 YITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLI----------------ALGSYNSFHN 314

Query: 344 SVLATLVVFAVLGFKANIMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYM 403
           +V    ++              C+        G++  +++           +H+T +   
Sbjct: 315 NVYRDSIIVC------------CINSCTSMFAGFVIFSIVGF--------MAHVTKRSIA 354

Query: 404 EMYNVIMTVKEDQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFF 463
                                       D +  G GLAF+A+ EA+T  P SP W+++FF
Sbjct: 355 ----------------------------DVAASGPGLAFLAYPEAVTQLPISPLWAILFF 386

Query: 464 LMLINLGLGSMIGTMAGITTPIIDTF----KVPKEMFTVGCCVFAFLVGLLFVQRSGNYF 519
            ML+ LG+ S   T+ G  T ++D +    +  +E+F    C+ ++L+GL  + + G Y 
Sbjct: 387 SMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYV 446

Query: 520 VTMFDDYSAT-LPLTLIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPL 578
             +FD YSA+ + L  +V  E ++++W YG  +F   + EM+G RP  ++   W F +P+
Sbjct: 447 FKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPI 506

Query: 579 CMAVLTTASIIQLGVTPPGYSAWIKEEAAERYLYFPNWAMAL--LITLIVVATLP 631
            +A +   S +Q+  TP     ++          FP W   +  L+ L  +  +P
Sbjct: 507 IVAGVFIFSAVQM--TPLTMGNYV----------FPKWGQGVGWLMALSSMVLIP 549


>gi|92859670 solute carrier family 6 (neurotransmitter transporter,
           glycine), member 5 [Homo sapiens]
          Length = 797

 Score =  313 bits (803), Expect = 3e-85
 Identities = 202/639 (31%), Positives = 316/639 (49%), Gaps = 129/639 (20%)

Query: 50  AVEEELDAEDRPA---WNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLL 106
           A +E+   ++  A   W+SKL +IL+ +G++VGLGN+WRFPYL  +NGGGA+L+PYL++L
Sbjct: 178 ATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMML 237

Query: 107 IIIGIPLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIF 166
            + G+P+FFLE+++GQ   +G + VW  I P L G G +  I+ + + +YYNVII +++F
Sbjct: 238 ALAGLPIFFLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYTLF 296

Query: 167 YFFKSFQYPLPWSEC-------------------------PVVR------------NGSV 189
           Y F SF   LPW  C                         P ++            N ++
Sbjct: 297 YLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTM 356

Query: 190 AVVEAECEK---SSATTYFWYREALDISDSISESGGLNWKMTLCLLVAWSIVGMAVVKGI 246
               ++  K   S +  YF Y   L IS  I   G + W + LCL +AW IV  ++ KGI
Sbjct: 357 VNFTSQANKTFVSGSEEYFKYF-VLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGI 415

Query: 247 QSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVF 306
           ++SGKV+YF++ FPYVVL   L+RG+ L GA  GI +  TPK +K+ D  VW++AATQ+F
Sbjct: 416 KTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIF 475

Query: 307 FALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKAN--IMNE 364
           F+L   +GG+I  SSYNK  NNC+ D  +V+  N  TS+ A  V+F+V+GF AN   +N 
Sbjct: 476 FSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNI 535

Query: 365 KCVVENAEKILGYLNTNVLSRDLIPPH---VNFSHLTTKDYMEMYNVIMTVKEDQFSALG 421
           + V +    I   +    L+R  + P    + F  L T     M+  I T+         
Sbjct: 536 ENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTS------ 589

Query: 422 LDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPF-WSVMFFLMLINLGLGSMIGTMAG 480
                + DE  K ++             TH P       + FF+M      G  + T  G
Sbjct: 590 -----ISDEFPKYLR-------------THKPVFTLGCCICFFIM------GFPMITQGG 625

Query: 481 ITTPIIDTFKVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILEN 540
           I                                    Y   + D Y+A+  L +I I E 
Sbjct: 626 I------------------------------------YMFQLVDTYAASYALVIIAIFEL 649

Query: 541 IAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSA 600
           + ++++YG ++F +++  M+GF+P  F+   W FV+P  +  +   S  Q    P  Y +
Sbjct: 650 VGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQW--EPMTYGS 707

Query: 601 WIKEEAAERYLYFPNWAMALLITLIVVATLPIPVVFVLR 639
           +           +PNW+M L   ++  + + IP++FV++
Sbjct: 708 Y----------RYPNWSMVLGWLMLACSVIWIPIMFVIK 736


>gi|4507043 solute carrier family 6 member 4 [Homo sapiens]
          Length = 630

 Score =  303 bits (776), Expect = 4e-82
 Identities = 174/560 (31%), Positives = 291/560 (51%), Gaps = 71/560 (12%)

Query: 54  ELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPL 113
           EL   +R  W  K+ ++L+ IG++V LGN+WRFPY+C +NGGGA+L+PY ++ I  GIPL
Sbjct: 73  ELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPL 132

Query: 114 FFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQ 173
           F++ELA+GQ  R G I +W  ICP   GIG++ CI+  ++  YYN I+ W+++Y   SF 
Sbjct: 133 FYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFT 192

Query: 174 YPLPWSECPVVRN-GSVAVVEAE------CEKSSATTYFWYREALDI--SDSISESGGLN 224
             LPW+ C    N G+     +E         +S    F+ R  L I  S  + + GG++
Sbjct: 193 DQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGIS 252

Query: 225 WKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHM 284
           W++ LC+++ ++++  ++ KG+++SGKV++ ++ FPY++L+  LVRG  L GA  G+L  
Sbjct: 253 WQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFY 312

Query: 285 FTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTS 344
             P   K+L+  VW +AA Q+FF+LG GFG ++AF+SYNK +NNC+ DA + S +N  TS
Sbjct: 313 LKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTS 372

Query: 345 VLATLVVFAVLGFKANIMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYME 404
            ++  V+F VLG+ A + NE              + + +++D  P  +         ++ 
Sbjct: 373 FVSGFVIFTVLGYMAEMRNE--------------DVSEVAKDAGPSLL---------FIT 409

Query: 405 MYNVIMTVKEDQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFL 464
               I  +    F A+     L+   LD +  G      A  +   H      W+     
Sbjct: 410 YAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPH-----VWAKRRER 464

Query: 465 MLINLGLGSMIGTMAGITTPIIDTFKVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFD 524
            ++ + +    G++  +T                     A++V LL    +G   +T+  
Sbjct: 465 FVLAVVITCFFGSLVTLTFG------------------GAYVVKLLEEYATGPAVLTV-- 504

Query: 525 DYSATLPLTLIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLT 584
                       ++E +AV+W YG  +F +++ EMLGF P  F+   W  +SPL +  + 
Sbjct: 505 -----------ALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFII 553

Query: 585 TASII---QLGVTPPGYSAW 601
            + ++   QL +    Y  W
Sbjct: 554 CSFLMSPPQLRLFQYNYPYW 573


>gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo
           sapiens]
          Length = 633

 Score =  300 bits (767), Expect = 4e-81
 Identities = 189/629 (30%), Positives = 309/629 (49%), Gaps = 106/629 (16%)

Query: 42  GEAGGKQKAVEEELDAED----RPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGA 97
           G  G    AV  E    D    R  W ++++++L  +G++VGLGN+WRFPYLC +NGGGA
Sbjct: 5   GAKGMLNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGA 64

Query: 98  YLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYY 157
           ++ PY ++LI  GIPLFF+EL+ GQ   +G +GVW  I P   G+G+   +V  ++G+YY
Sbjct: 65  FMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYY 123

Query: 158 NVIIGWSIFYFFKSFQYPLPWSEC--PVVRNGSVAVVEAE-------------------- 195
           NV+I  + +YFF S  + LPW+ C  P   +    V++A                     
Sbjct: 124 NVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLN 183

Query: 196 --CEKSSATTYFWYREALDISDSISESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVM 253
              +++S +  +W    L +SD I   G +   +  CL V+W +V + +++G++SSGKV+
Sbjct: 184 HSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVV 243

Query: 254 YFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGF 313
           YF++ FPYVVL    VRG+ L GA DGI++  TP+ DK+L+ +VW +AA+Q+F++LG  +
Sbjct: 244 YFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAW 303

Query: 314 GGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKANIM--NEKCVVENA 371
           GG+I  +SYNK  NNC+ D+ ++S  N  TSV A  V+F++LGF AN +  +   V ++ 
Sbjct: 304 GGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHG 363

Query: 372 EKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQFSALGLDPCLLEDEL 431
             +        L+  L+P     S L +  +  M  ++          LG   CLLE  +
Sbjct: 364 PGLAFVAYPEALT--LLP----ISPLWSLLFFFMLILL---------GLGTQFCLLETLV 408

Query: 432 DKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGI-TTPIIDTFK 490
              V   G  +I   +            V   + +    LG  + + AGI    ++D + 
Sbjct: 409 TAIVDEVGNEWILQKKTY----------VTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYA 458

Query: 491 VPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILENIAVAWIYGTK 550
               +  + C +    V ++++    NYF                               
Sbjct: 459 ASFSLVVISCIM---CVAIMYIYGHRNYF------------------------------- 484

Query: 551 KFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSAWIKEEAAERY 610
              Q++  MLGF P  F+   W+FVSP  +  +   ++IQ             +     +
Sbjct: 485 ---QDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQY------------QPITYNH 529

Query: 611 LYFPNWAMALLITLIVVATLPIPVVFVLR 639
             +P WA+A+   + + + L IP+  + R
Sbjct: 530 YQYPGWAVAIGFLMALSSVLCIPLYAMFR 558


>gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo
           sapiens]
          Length = 652

 Score =  299 bits (766), Expect = 5e-81
 Identities = 189/631 (29%), Positives = 311/631 (49%), Gaps = 106/631 (16%)

Query: 40  VAGEAGGKQKAVEEELDAED----RPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGG 95
           VA  +  +  AV  E    D    R  W ++++++L  +G++VGLGN+WRFPYLC +NGG
Sbjct: 22  VAPSSPEQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGG 81

Query: 96  GAYLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGL 155
           GA++ PY ++LI  GIPLFF+EL+ GQ   +G +GVW  I P   G+G+   +V  ++G+
Sbjct: 82  GAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGI 140

Query: 156 YYNVIIGWSIFYFFKSFQYPLPWSEC--PVVRNGSVAVVEAE------------------ 195
           YYNV+I  + +YFF S  + LPW+ C  P   +    V++A                   
Sbjct: 141 YYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHL 200

Query: 196 ----CEKSSATTYFWYREALDISDSISESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGK 251
                +++S +  +W    L +SD I   G +   +  CL V+W +V + +++G++SSGK
Sbjct: 201 LNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGK 260

Query: 252 VMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGL 311
           V+YF++ FPYVVL    VRG+ L GA DGI++  TP+ DK+L+ +VW +AA+Q+F++LG 
Sbjct: 261 VVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGC 320

Query: 312 GFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKANIM--NEKCVVE 369
            +GG+I  +SYNK  NNC+ D+ ++S  N  TSV A  V+F++LGF AN +  +   V +
Sbjct: 321 AWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVAD 380

Query: 370 NAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQFSALGLDPCLLED 429
           +   +        L+  L+P     S L +  +  M  ++          LG   CLLE 
Sbjct: 381 HGPGLAFVAYPEALT--LLP----ISPLWSLLFFFMLILL---------GLGTQFCLLET 425

Query: 430 ELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGI-TTPIIDT 488
            +   V   G  +I   +            V   + +    LG  + + AGI    ++D 
Sbjct: 426 LVTAIVDEVGNEWILQKKTY----------VTLGVAVAGFLLGIPLTSQAGIYWLLLMDN 475

Query: 489 FKVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILENIAVAWIYG 548
           +     +  + C +    V ++++    NYF                             
Sbjct: 476 YAASFSLVVISCIM---CVAIMYIYGHRNYF----------------------------- 503

Query: 549 TKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSAWIKEEAAE 608
                Q++  MLGF P  F+   W+FVSP  +  +   ++IQ             +    
Sbjct: 504 -----QDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQY------------QPITY 546

Query: 609 RYLYFPNWAMALLITLIVVATLPIPVVFVLR 639
            +  +P WA+A+   + + + L IP+  + R
Sbjct: 547 NHYQYPGWAVAIGFLMALSSVLCIPLYAMFR 577


>gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo
           sapiens]
          Length = 706

 Score =  298 bits (764), Expect = 9e-81
 Identities = 183/607 (30%), Positives = 303/607 (49%), Gaps = 102/607 (16%)

Query: 60  RPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELA 119
           R  W ++++++L  +G++VGLGN+WRFPYLC +NGGGA++ PY ++LI  GIPLFF+EL+
Sbjct: 100 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELS 159

Query: 120 VGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWS 179
            GQ   +G +GVW  I P   G+G+   +V  ++G+YYNV+I  + +YFF S  + LPW+
Sbjct: 160 FGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWA 218

Query: 180 EC--PVVRNGSVAVVEAE----------------------CEKSSATTYFWYREALDISD 215
            C  P   +    V++A                        +++S +  +W    L +SD
Sbjct: 219 YCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSD 278

Query: 216 SISESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLR 275
            I   G +   +  CL V+W +V + +++G++SSGKV+YF++ FPYVVL    VRG+ L 
Sbjct: 279 DIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLE 338

Query: 276 GAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAAL 335
           GA DGI++  TP+ DK+L+ +VW +AA+Q+F++LG  +GG+I  +SYNK  NNC+ D+ +
Sbjct: 339 GAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVI 398

Query: 336 VSFINFFTSVLATLVVFAVLGFKANIM--NEKCVVENAEKILGYLNTNVLSRDLIPPHVN 393
           +S  N  TSV A  V+F++LGF AN +  +   V ++   +        L+  L+P    
Sbjct: 399 ISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALT--LLP---- 452

Query: 394 FSHLTTKDYMEMYNVIMTVKEDQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFP 453
            S L +  +  M  ++          LG   CLLE  +   V   G  +I   +      
Sbjct: 453 ISPLWSLLFFFMLILL---------GLGTQFCLLETLVTAIVDEVGNEWILQKKTY---- 499

Query: 454 ASPFWSVMFFLMLINLGLGSMIGTMAGI-TTPIIDTFKVPKEMFTVGCCVFAFLVGLLFV 512
                 V   + +    LG  + + AGI    ++D +     +  + C +    V ++++
Sbjct: 500 ------VTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIM---CVAIMYI 550

Query: 513 QRSGNYFVTMFDDYSATLPLTLIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMW 572
               NYF                                  Q++  MLGF P  F+   W
Sbjct: 551 YGHRNYF----------------------------------QDIQMMLGFPPPLFFQICW 576

Query: 573 KFVSPLCMAVLTTASIIQLGVTPPGYSAWIKEEAAERYLYFPNWAMALLITLIVVATLPI 632
           +FVSP  +  +   ++IQ             +     +  +P WA+A+   + + + L I
Sbjct: 577 RFVSPAIIFFILVFTVIQY------------QPITYNHYQYPGWAVAIGFLMALSSVLCI 624

Query: 633 PVVFVLR 639
           P+  + R
Sbjct: 625 PLYAMFR 631


>gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo
           sapiens]
          Length = 635

 Score =  292 bits (748), Expect = 7e-79
 Identities = 135/317 (42%), Positives = 205/317 (64%), Gaps = 18/317 (5%)

Query: 60  RPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELA 119
           R  W  ++ +I++ +GF+VGLGN+WRFPYLC KNGGG +L+PY+++ ++ GIP+FFLE++
Sbjct: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111

Query: 120 VGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWS 179
           +GQ ++ GSI VW+ ICP   G+G++S ++  +   YY +++ W  +Y  KSF   LPW+
Sbjct: 112 LGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170

Query: 180 EC----------PVVR-----NGSVAVVEAE--CEKSSATTYFWYREALDISDSISESGG 222
            C           + R     N S+A +  +   ++ S    FW  + L +S  +   G 
Sbjct: 171 TCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGA 230

Query: 223 LNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGIL 282
           LNW++TLCLL  W +V   V KG++S+GK++YF++ FPYVVL   LVRG+LL GA+DGI+
Sbjct: 231 LNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGII 290

Query: 283 HMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFF 342
           +   P   K+  PQVW +A TQ+FF+  +G G + A  SYN+ +NNC+ DA +++ IN  
Sbjct: 291 YYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSG 350

Query: 343 TSVLATLVVFAVLGFKA 359
           TS  A  VVF++LGF A
Sbjct: 351 TSFFAGFVVFSILGFMA 367



 Score =  106 bits (265), Expect = 7e-23
 Identities = 56/154 (36%), Positives = 83/154 (53%), Gaps = 8/154 (5%)

Query: 437 GTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDT------FK 490
           G GLAFIA+  A+T  P +P W+ +FF ML+ LGL S    + G  T ++D       F+
Sbjct: 381 GPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFR 440

Query: 491 VPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSAT-LPLTLIVILENIAVAWIYGT 549
             +E+    CC   F++ L  V   G Y   +FD YSA+   L      E + VAW+YG 
Sbjct: 441 FQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGA 500

Query: 550 KKFMQELTEMLGFRPYRFYFYMWKFVSPL-CMAV 582
            +FM ++  M+G+RP  +  + W F +PL CM +
Sbjct: 501 DRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGI 534


>gi|171184408 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  289 bits (740), Expect = 6e-78
 Identities = 132/322 (40%), Positives = 198/322 (61%), Gaps = 10/322 (3%)

Query: 46  GKQKAVEEELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVL 105
           G++   E+E   +DR  W +K++++L+  G  +GLGN+WRFPYLC KNGGGA+ +PY + 
Sbjct: 22  GEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIF 81

Query: 106 LIIIGIPLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSI 165
             + GIP+FFLE+A+GQ   +GS+  W  ICP   GIG +S ++  ++ +YY +I+ W++
Sbjct: 82  FFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWAL 141

Query: 166 FYFFKSFQYPLPWSEC----------PVVRNGSVAVVEAECEKSSATTYFWYREALDISD 215
           FY F SF   LPW+ C            + +     V      +S    FW R  L I+ 
Sbjct: 142 FYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITS 201

Query: 216 SISESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLR 275
            I + G L W++ LCLL+AW I    + KG++S+GKV+YF++ FPY++L   L+RG+ L 
Sbjct: 202 GIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLP 261

Query: 276 GAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAAL 335
           GA  GI++   P L ++ DPQVW +A TQ+FF+  +  G + A  SYNK  NNC+ D   
Sbjct: 262 GAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIA 321

Query: 336 VSFINFFTSVLATLVVFAVLGF 357
           + F+N  TS +A  VVF++LGF
Sbjct: 322 LCFLNSATSFVAGFVVFSILGF 343



 Score =  103 bits (256), Expect = 7e-22
 Identities = 55/153 (35%), Positives = 84/153 (54%), Gaps = 8/153 (5%)

Query: 437 GTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTF------K 490
           G GLAFIAF +A+T  P S  WS +FF+MLI LGL S    +  + T  ID F       
Sbjct: 359 GPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKS 418

Query: 491 VPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDY-SATLPLTLIVILENIAVAWIYGT 549
             +E+  +   V  +L+GL  V   G Y   +FD Y S+ + L  + + E + ++W+YG 
Sbjct: 419 GRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGA 478

Query: 550 KKFMQELTEMLGFRPYRFYFYMWKFVSP-LCMA 581
            +F   + +M+G+RP+      W F++P LC+A
Sbjct: 479 DRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLA 511


>gi|171184406 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  289 bits (740), Expect = 6e-78
 Identities = 132/322 (40%), Positives = 198/322 (61%), Gaps = 10/322 (3%)

Query: 46  GKQKAVEEELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVL 105
           G++   E+E   +DR  W +K++++L+  G  +GLGN+WRFPYLC KNGGGA+ +PY + 
Sbjct: 22  GEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIF 81

Query: 106 LIIIGIPLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSI 165
             + GIP+FFLE+A+GQ   +GS+  W  ICP   GIG +S ++  ++ +YY +I+ W++
Sbjct: 82  FFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWAL 141

Query: 166 FYFFKSFQYPLPWSEC----------PVVRNGSVAVVEAECEKSSATTYFWYREALDISD 215
           FY F SF   LPW+ C            + +     V      +S    FW R  L I+ 
Sbjct: 142 FYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITS 201

Query: 216 SISESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLR 275
            I + G L W++ LCLL+AW I    + KG++S+GKV+YF++ FPY++L   L+RG+ L 
Sbjct: 202 GIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLP 261

Query: 276 GAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAAL 335
           GA  GI++   P L ++ DPQVW +A TQ+FF+  +  G + A  SYNK  NNC+ D   
Sbjct: 262 GAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIA 321

Query: 336 VSFINFFTSVLATLVVFAVLGF 357
           + F+N  TS +A  VVF++LGF
Sbjct: 322 LCFLNSATSFVAGFVVFSILGF 343



 Score =  103 bits (256), Expect = 7e-22
 Identities = 55/153 (35%), Positives = 84/153 (54%), Gaps = 8/153 (5%)

Query: 437 GTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTF------K 490
           G GLAFIAF +A+T  P S  WS +FF+MLI LGL S    +  + T  ID F       
Sbjct: 359 GPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKS 418

Query: 491 VPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDY-SATLPLTLIVILENIAVAWIYGT 549
             +E+  +   V  +L+GL  V   G Y   +FD Y S+ + L  + + E + ++W+YG 
Sbjct: 419 GRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGA 478

Query: 550 KKFMQELTEMLGFRPYRFYFYMWKFVSP-LCMA 581
            +F   + +M+G+RP+      W F++P LC+A
Sbjct: 479 DRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLA 511


>gi|171184404 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  289 bits (740), Expect = 6e-78
 Identities = 132/322 (40%), Positives = 198/322 (61%), Gaps = 10/322 (3%)

Query: 46  GKQKAVEEELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVL 105
           G++   E+E   +DR  W +K++++L+  G  +GLGN+WRFPYLC KNGGGA+ +PY + 
Sbjct: 22  GEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIF 81

Query: 106 LIIIGIPLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSI 165
             + GIP+FFLE+A+GQ   +GS+  W  ICP   GIG +S ++  ++ +YY +I+ W++
Sbjct: 82  FFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWAL 141

Query: 166 FYFFKSFQYPLPWSEC----------PVVRNGSVAVVEAECEKSSATTYFWYREALDISD 215
           FY F SF   LPW+ C            + +     V      +S    FW R  L I+ 
Sbjct: 142 FYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITS 201

Query: 216 SISESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLR 275
            I + G L W++ LCLL+AW I    + KG++S+GKV+YF++ FPY++L   L+RG+ L 
Sbjct: 202 GIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLP 261

Query: 276 GAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAAL 335
           GA  GI++   P L ++ DPQVW +A TQ+FF+  +  G + A  SYNK  NNC+ D   
Sbjct: 262 GAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIA 321

Query: 336 VSFINFFTSVLATLVVFAVLGF 357
           + F+N  TS +A  VVF++LGF
Sbjct: 322 LCFLNSATSFVAGFVVFSILGF 343



 Score =  103 bits (256), Expect = 7e-22
 Identities = 55/153 (35%), Positives = 84/153 (54%), Gaps = 8/153 (5%)

Query: 437 GTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTF------K 490
           G GLAFIAF +A+T  P S  WS +FF+MLI LGL S    +  + T  ID F       
Sbjct: 359 GPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKS 418

Query: 491 VPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDY-SATLPLTLIVILENIAVAWIYGT 549
             +E+  +   V  +L+GL  V   G Y   +FD Y S+ + L  + + E + ++W+YG 
Sbjct: 419 GRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGA 478

Query: 550 KKFMQELTEMLGFRPYRFYFYMWKFVSP-LCMA 581
            +F   + +M+G+RP+      W F++P LC+A
Sbjct: 479 DRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLA 511


>gi|21361581 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 13 [Homo sapiens]
          Length = 602

 Score =  283 bits (724), Expect = 4e-76
 Identities = 133/317 (41%), Positives = 191/317 (60%), Gaps = 13/317 (4%)

Query: 52  EEELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGI 111
           +EE    +R  WN+K++++L+  G  +GLGN+WRFPYLC KNGGGA+ +PYLV L   GI
Sbjct: 24  KEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGI 83

Query: 112 PLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKS 171
           P+F LE A+GQ   +G +  W  ICP   GIG++S ++ + + +YY +++ W++FY F S
Sbjct: 84  PVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSS 143

Query: 172 FQYPLPWSECP-----------VVRNGSVAVVEAECEKSSATTYFWYREALDISDSISES 220
           F   LPW  C               NGS+         +S    FW R  L ISD I   
Sbjct: 144 FTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENA--TSPVIEFWERRVLKISDGIQHL 201

Query: 221 GGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDG 280
           G L W++ LCLL+AW I    + KG++S+GKV+YF++ FPY++L   L+RG+ L GA  G
Sbjct: 202 GALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQG 261

Query: 281 ILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFIN 340
           I     P L ++ DPQVW +A TQ+FF+  +  G + A  SYNK  NNC+ D   + F+N
Sbjct: 262 IQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLN 321

Query: 341 FFTSVLATLVVFAVLGF 357
             TS +A   +F++LGF
Sbjct: 322 SGTSFVAGFAIFSILGF 338



 Score =  116 bits (290), Expect = 8e-26
 Identities = 68/204 (33%), Positives = 108/204 (52%), Gaps = 18/204 (8%)

Query: 437 GTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTF------K 490
           G GLAFIA+  A+   P SP W+  FF M++ LGL S    +  + T ++D +      K
Sbjct: 354 GPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKK 413

Query: 491 VPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSAT-LPLTLIVILENIAVAWIYGT 549
             +E+  +G  V +FLVGL+ +   G Y   +FD Y+A+ + L  + I E++ VAW+YG 
Sbjct: 414 NRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGA 473

Query: 550 KKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSAWIKEEAAER 609
           K+F   + +M+G+RP+    Y W F++P         S+I+   TP  Y+        ++
Sbjct: 474 KRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIK--YTPLTYN--------KK 523

Query: 610 YLYFPNWAMALLITLIVVATLPIP 633
           Y Y P W  AL   L + + + IP
Sbjct: 524 YTY-PWWGDALGWLLALSSMVCIP 546


>gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo
           sapiens]
          Length = 625

 Score =  277 bits (708), Expect = 3e-74
 Identities = 131/317 (41%), Positives = 198/317 (62%), Gaps = 28/317 (8%)

Query: 60  RPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELA 119
           R  W  ++ +I++ +GF+VGLGN+WRFPYLC KNGGG +L+PY+++ ++ GIP+FFLE++
Sbjct: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111

Query: 120 VGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWS 179
           +GQ ++ GSI VW+ ICP   G+G++S ++  +   YY +++ W  +Y  KSF   LPW+
Sbjct: 112 LGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170

Query: 180 EC----------PVVR-----NGSVAVVEAE--CEKSSATTYFWYREALDISDSISESGG 222
            C           + R     N S+A +  +   ++ S    FW  + L +S  +   G 
Sbjct: 171 TCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGA 230

Query: 223 LNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGIL 282
           LNW++TLCLL  W +V   V KG++S+GK++YF++ FPYVVL   LVRG+LL GA+DGI+
Sbjct: 231 LNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGII 290

Query: 283 HMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFF 342
           +   P   K+  PQVW +A TQ+FF+  +G G + A  SYN+ +NNC+            
Sbjct: 291 YYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYNG---------- 340

Query: 343 TSVLATLVVFAVLGFKA 359
           TS  A  VVF++LGF A
Sbjct: 341 TSFFAGFVVFSILGFMA 357



 Score =  106 bits (265), Expect = 7e-23
 Identities = 56/154 (36%), Positives = 83/154 (53%), Gaps = 8/154 (5%)

Query: 437 GTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDT------FK 490
           G GLAFIA+  A+T  P +P W+ +FF ML+ LGL S    + G  T ++D       F+
Sbjct: 371 GPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFR 430

Query: 491 VPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSAT-LPLTLIVILENIAVAWIYGT 549
             +E+    CC   F++ L  V   G Y   +FD YSA+   L      E + VAW+YG 
Sbjct: 431 FQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGA 490

Query: 550 KKFMQELTEMLGFRPYRFYFYMWKFVSPL-CMAV 582
            +FM ++  M+G+RP  +  + W F +PL CM +
Sbjct: 491 DRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGI 524


>gi|4557046 solute carrier family 6 member 2 [Homo sapiens]
          Length = 617

 Score =  276 bits (705), Expect = 6e-74
 Identities = 145/343 (42%), Positives = 212/343 (61%), Gaps = 17/343 (4%)

Query: 34  KQSVLNVAGEAGGKQKAVE-EELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQK 92
           K + L V  E  G Q  +   + DA+ R  W  K+ ++L+ +GF+V L N+WRFPYLC K
Sbjct: 29  KTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYK 88

Query: 93  NGGGAYLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLF 152
           NGGGA+L+PY + LII G+PLF++ELA+GQ  R G+  VW  ICP   G+G++  ++ L+
Sbjct: 89  NGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWK-ICPFFKGVGYAVILIALY 147

Query: 153 VGLYYNVIIGWSIFYFFKSFQYPLPWSEC-----------PVVRNGSVAVVEAECEKSSA 201
           VG YYNVII WS++Y F SF   LPW++C           P + NGSV     +  K   
Sbjct: 148 VGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKF 207

Query: 202 T--TYFWYREALDISDS--ISESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSS 257
           T    F+ R  L + +S  I + G   W++ LCL+V   ++  ++ KG+++SGKV++ ++
Sbjct: 208 TPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITA 267

Query: 258 LFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVI 317
             PY VL   LV G+ L GA +GI         ++ +  VW +AATQ+FF+LG GFG +I
Sbjct: 268 TLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLI 327

Query: 318 AFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKAN 360
           AF+SYNK DNNC+ DA L S IN  TS ++   +F++LG+ A+
Sbjct: 328 AFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAH 370



 Score =  127 bits (319), Expect = 4e-29
 Identities = 72/210 (34%), Positives = 113/210 (53%), Gaps = 17/210 (8%)

Query: 432 DKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTFKV 491
           D + +G GL FI + EA++    S FW+V+FF+ML+ LGL S +G M  + T + D F+V
Sbjct: 378 DVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQV 437

Query: 492 PK---EMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILENIAVAWIYG 548
            K   ++FT G     FL+ L  + + G Y +T+ D ++A   +   V++E I V+W YG
Sbjct: 438 LKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYG 497

Query: 549 TKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSAWIKEEAAE 608
             +F  ++ +M+GFRP  ++   WKFVSP  +  +   SII     P  Y  +I      
Sbjct: 498 VDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF--KPLTYDDYI------ 549

Query: 609 RYLYFPNWA--MALLITLIVVATLPIPVVF 636
               FP WA  +   I L  +  +PI V++
Sbjct: 550 ----FPPWANWVGWGIALSSMVLVPIYVIY 575


>gi|197276623 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  275 bits (702), Expect = 1e-73
 Identities = 132/341 (38%), Positives = 198/341 (58%), Gaps = 13/341 (3%)

Query: 32  DYKQSVLNVA-GEAGGKQKAVEEELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLC 90
           D+ + +L  + G++ G +   E E     R  W+SK+ ++L+  G  VGLGN+WRFPYLC
Sbjct: 12  DFHKDILKPSPGKSPGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLC 71

Query: 91  QKNGGGAYLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVC 150
            KNGGGA+L+PY + L   G+P+FFLE+ +GQ    G I  W  ICP   GIG++S ++ 
Sbjct: 72  YKNGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIV 131

Query: 151 LFVGLYYNVIIGWSIFYFFKSFQYPLPWSEC------------PVVRNGSVAVVEAECEK 198
             + +YY VI+ W+ +Y F+SFQ  LPW+ C             + +N SV +  +    
Sbjct: 132 SLLNVYYIVILAWATYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNF 191

Query: 199 SSATTYFWYREALDISDSISESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSL 258
           +S    FW R  L +S  I   G L W + LCLL+ W +    + KG++S+GKV+YF++ 
Sbjct: 192 TSPVIEFWERNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTAT 251

Query: 259 FPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIA 318
           FP+ +L   LVRGL L GA  GI     P + ++ DPQVW +A TQ+FF+  +  G + +
Sbjct: 252 FPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTS 311

Query: 319 FSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKA 359
             SYNK   N + D  L+  +N  TS ++   +F++LGF A
Sbjct: 312 LGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMA 352


>gi|54607094 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  275 bits (702), Expect = 1e-73
 Identities = 132/341 (38%), Positives = 198/341 (58%), Gaps = 13/341 (3%)

Query: 32  DYKQSVLNVA-GEAGGKQKAVEEELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLC 90
           D+ + +L  + G++ G +   E E     R  W+SK+ ++L+  G  VGLGN+WRFPYLC
Sbjct: 12  DFHKDILKPSPGKSPGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLC 71

Query: 91  QKNGGGAYLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVC 150
            KNGGGA+L+PY + L   G+P+FFLE+ +GQ    G I  W  ICP   GIG++S ++ 
Sbjct: 72  YKNGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIV 131

Query: 151 LFVGLYYNVIIGWSIFYFFKSFQYPLPWSEC------------PVVRNGSVAVVEAECEK 198
             + +YY VI+ W+ +Y F+SFQ  LPW+ C             + +N SV +  +    
Sbjct: 132 SLLNVYYIVILAWATYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNF 191

Query: 199 SSATTYFWYREALDISDSISESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSL 258
           +S    FW R  L +S  I   G L W + LCLL+ W +    + KG++S+GKV+YF++ 
Sbjct: 192 TSPVIEFWERNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTAT 251

Query: 259 FPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIA 318
           FP+ +L   LVRGL L GA  GI     P + ++ DPQVW +A TQ+FF+  +  G + +
Sbjct: 252 FPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTS 311

Query: 319 FSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKA 359
             SYNK   N + D  L+  +N  TS ++   +F++LGF A
Sbjct: 312 LGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMA 352


>gi|7657587 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 11 [Homo sapiens]
          Length = 632

 Score =  274 bits (701), Expect = 2e-73
 Identities = 133/332 (40%), Positives = 194/332 (58%), Gaps = 17/332 (5%)

Query: 42  GEAGGKQKAVEEELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVP 101
           G A  +   V+ +    +R  WN+K++++L+  G  +GLGN+WRFPYLC KNGGGA+L+P
Sbjct: 32  GAAPARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIP 91

Query: 102 YLVLLIIIGIPLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVII 161
           Y+V  I  GIP+FFLE A+GQ    G I  W  +CP   GIG+++ ++   + +YY +I+
Sbjct: 92  YVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIIL 151

Query: 162 GWSIFYFFKSFQYPLPWSECPVVRNGSVAVVEAECEKSSATTY--------------FWY 207
            W+IFY    F   LPW+ C    N    V   E +K + + Y              FW 
Sbjct: 152 AWAIFYLSNCFTTELPWATCGHEWNTENCV---EFQKLNVSNYSHVSLQNATSPVMEFWE 208

Query: 208 REALDISDSISESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACF 267
              L ISD I   G L W++ LCLL AW+I    + KG +S+GKV+Y ++ FPY++L   
Sbjct: 209 HRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLIL 268

Query: 268 LVRGLLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDN 327
           L+RG+ L GA +GI     P L ++ DPQVW +A TQ+FF+  +  G + A  SYN  +N
Sbjct: 269 LIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNN 328

Query: 328 NCHFDAALVSFINFFTSVLATLVVFAVLGFKA 359
           NC+ D  ++  +N  TS +A   +F+VLGF A
Sbjct: 329 NCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMA 360



 Score =  104 bits (259), Expect = 3e-22
 Identities = 49/154 (31%), Positives = 86/154 (55%), Gaps = 8/154 (5%)

Query: 437 GTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTFK------ 490
           G GLAFIA+ +A+T  P SP W+ +FF+MLI LGL S    +  + T ++D +       
Sbjct: 374 GPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRG 433

Query: 491 VPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSAT-LPLTLIVILENIAVAWIYGT 549
             +E+  +   V ++ +GL+ +   G Y   +FD Y+A+ + L  + I E I + W+YG+
Sbjct: 434 YRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGS 493

Query: 550 KKFMQELTEMLGFRPYRFYFYMWKFVSP-LCMAV 582
            +F   + +M+G+RP     + W  ++P +C  +
Sbjct: 494 NRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGI 527


>gi|4507041 solute carrier family 6 (neurotransmitter transporter,
           dopamine), member 3 [Homo sapiens]
          Length = 620

 Score =  273 bits (699), Expect = 3e-73
 Identities = 139/323 (43%), Positives = 204/323 (63%), Gaps = 17/323 (5%)

Query: 52  EEELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGI 111
           +  ++A+DR  W  K+ ++L+ IGF+V L N+WRFPYLC KNGGGA+LVPYL+ ++I G+
Sbjct: 52  QSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGM 111

Query: 112 PLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKS 171
           PLF++ELA+GQ  R G+ GVW  ICP L G+GF+  ++ L+VG +YNVII W++ Y F S
Sbjct: 112 PLFYMELALGQFNREGAAGVWK-ICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSS 170

Query: 172 FQYPLPWSEC-------------PVVRNGSVAVVEAECEKSSATTYFWYREALDISDS-- 216
           F   LPW  C             P   +G  + +      + A  YF  R  L +  S  
Sbjct: 171 FTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYF-ERGVLHLHQSHG 229

Query: 217 ISESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRG 276
           I + G   W++T CL++   ++  ++ KG+++SGKV++ ++  PYVVL   L+RG+ L G
Sbjct: 230 IDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPG 289

Query: 277 AVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALV 336
           A+DGI    +    ++ +  VW +AATQV F+LG+GFG +IAFSSYNK  NNC+ DA + 
Sbjct: 290 AIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVT 349

Query: 337 SFINFFTSVLATLVVFAVLGFKA 359
           + IN  TS  +  VVF+ LG+ A
Sbjct: 350 TSINSLTSFSSGFVVFSFLGYMA 372



 Score =  124 bits (310), Expect = 4e-28
 Identities = 72/206 (34%), Positives = 110/206 (53%), Gaps = 17/206 (8%)

Query: 432 DKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTFKV 491
           D +  G GL FI + EA+   P S  W+V+FF+ML+ LG+ S +G M  + T +ID F++
Sbjct: 381 DVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQL 440

Query: 492 ---PKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILENIAVAWIYG 548
               +E+FT+   +  FL+ L  V   G Y  T+ D ++A   +   V++E I VAW YG
Sbjct: 441 LHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYG 500

Query: 549 TKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSAWIKEEAAE 608
             +F  ++ +M G RP  ++   WK VSP  +  +   SI+     PP Y A+I      
Sbjct: 501 VGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTF--RPPHYGAYI------ 552

Query: 609 RYLYFPNWAMAL--LITLIVVATLPI 632
               FP+WA AL  +I    +A +PI
Sbjct: 553 ----FPDWANALGWVIATSSMAMVPI 574


>gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo
           sapiens]
          Length = 520

 Score =  205 bits (522), Expect = 1e-52
 Identities = 101/253 (39%), Positives = 152/253 (60%), Gaps = 18/253 (7%)

Query: 124 IRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWSEC-- 181
           ++ GSI VW+ ICP   G+G++S ++  +   YY +++ W  +Y  KSF   LPW+ C  
Sbjct: 1   MKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGH 59

Query: 182 --------PVVR-----NGSVAVVEAE--CEKSSATTYFWYREALDISDSISESGGLNWK 226
                    + R     N S+A +  +   ++ S    FW  + L +S  +   G LNW+
Sbjct: 60  TWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWE 119

Query: 227 MTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFT 286
           +TLCLL  W +V   V KG++S+GK++YF++ FPYVVL   LVRG+LL GA+DGI++   
Sbjct: 120 VTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLK 179

Query: 287 PKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVL 346
           P   K+  PQVW +A TQ+FF+  +G G + A  SYN+ +NNC+ DA +++ IN  TS  
Sbjct: 180 PDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFF 239

Query: 347 ATLVVFAVLGFKA 359
           A  VVF++LGF A
Sbjct: 240 AGFVVFSILGFMA 252



 Score =  106 bits (265), Expect = 7e-23
 Identities = 56/154 (36%), Positives = 83/154 (53%), Gaps = 8/154 (5%)

Query: 437 GTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDT------FK 490
           G GLAFIA+  A+T  P +P W+ +FF ML+ LGL S    + G  T ++D       F+
Sbjct: 266 GPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFR 325

Query: 491 VPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSAT-LPLTLIVILENIAVAWIYGT 549
             +E+    CC   F++ L  V   G Y   +FD YSA+   L      E + VAW+YG 
Sbjct: 326 FQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGA 385

Query: 550 KKFMQELTEMLGFRPYRFYFYMWKFVSPL-CMAV 582
            +FM ++  M+G+RP  +  + W F +PL CM +
Sbjct: 386 DRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGI 419


>gi|197276625 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform b [Homo sapiens]
          Length = 200

 Score =  152 bits (385), Expect = 8e-37
 Identities = 66/151 (43%), Positives = 97/151 (64%), Gaps = 1/151 (0%)

Query: 32  DYKQSVLNVA-GEAGGKQKAVEEELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLC 90
           D+ + +L  + G++ G +   E E     R  W+SK+ ++L+  G  VGLGN+WRFPYLC
Sbjct: 12  DFHKDILKPSPGKSPGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLC 71

Query: 91  QKNGGGAYLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVC 150
            KNGGGA+L+PY + L   G+P+FFLE+ +GQ    G I  W  ICP   GIG++S ++ 
Sbjct: 72  YKNGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIV 131

Query: 151 LFVGLYYNVIIGWSIFYFFKSFQYPLPWSEC 181
             + +YY VI+ W+ +Y F+SFQ  LPW+ C
Sbjct: 132 SLLNVYYIVILAWATYYLFQSFQKELPWAHC 162


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.140    0.432 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,137,834
Number of Sequences: 37866
Number of extensions: 1222608
Number of successful extensions: 4257
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 4095
Number of HSP's gapped (non-prelim): 61
length of query: 727
length of database: 18,247,518
effective HSP length: 110
effective length of query: 617
effective length of database: 14,082,258
effective search space: 8688753186
effective search space used: 8688753186
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.