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Search of human proteins with 5803181
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5803181 stress-induced-phosphoprotein 1
(Hsp70/Hsp90-organizing protein) [Homo sapiens]
(543 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizi... 1103 0.0
gi|27262638 sperm associated antigen 1 [Homo sapiens] 117 3e-26
gi|27262636 sperm associated antigen 1 [Homo sapiens] 117 3e-26
gi|225735593 RNA polymerase II associated protein 3 isoform 2 [H... 103 5e-22
gi|225735591 RNA polymerase II associated protein 3 isoform 1 [H... 103 5e-22
gi|24308141 small glutamine-rich tetratricopeptide repeat (TPR)-... 89 1e-17
gi|54607135 translocase of outer mitochondrial membrane 70 homol... 88 2e-17
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens] 85 2e-16
gi|225735595 RNA polymerase II associated protein 3 isoform 3 [H... 82 1e-15
gi|4506921 small glutamine-rich tetratricopeptide [Homo sapiens] 81 3e-15
gi|221219056 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform... 79 8e-15
gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform... 79 8e-15
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] 79 1e-14
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] 79 1e-14
gi|90669931 tetratricopeptide repeat domain 12 [Homo sapiens] 79 1e-14
gi|5453958 protein phosphatase 5, catalytic subunit [Homo sapiens] 73 6e-13
gi|4507711 tetratricopeptide repeat domain 1 [Homo sapiens] 71 2e-12
gi|21361356 translocase of outer mitochondrial membrane 34 [Homo... 70 6e-12
gi|49640011 tetratricopeptide repeat domain 3 [Homo sapiens] 67 4e-11
gi|49640009 tetratricopeptide repeat domain 3 [Homo sapiens] 67 4e-11
gi|56181387 STIP1 homology and U-box containing protein 1 [Homo ... 64 3e-10
gi|73747840 LON peptidase N-terminal domain and ring finger 3 is... 64 5e-10
gi|75677570 dyslexia susceptibility 1 candidate 1 isoform a [Hom... 62 1e-09
gi|89179321 smooth muscle cell associated protein-1 isoform 3 [H... 61 3e-09
gi|29725607 smooth muscle cell associated protein-1 isoform 2 [H... 61 3e-09
gi|238859655 tetratricopeptide repeat domain 31 [Homo sapiens] 60 5e-09
gi|33457330 tetratricopeptide repeat domain 14 isoform a [Homo s... 59 1e-08
gi|5453980 DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo sap... 58 2e-08
gi|13899233 tetratricopeptide repeat domain 25 [Homo sapiens] 58 2e-08
gi|22095349 WD and tetratricopeptide repeats 1 [Homo sapiens] 57 3e-08
>gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing
protein) [Homo sapiens]
Length = 543
Score = 1103 bits (2852), Expect = 0.0
Identities = 543/543 (100%), Positives = 543/543 (100%)
Query: 1 MEQVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYED 60
MEQVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYED
Sbjct: 1 MEQVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYED 60
Query: 61 GCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLA 120
GCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLA
Sbjct: 61 GCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLA 120
Query: 121 ERKFMNPFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTKLQDPRIMTTLS 180
ERKFMNPFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTKLQDPRIMTTLS
Sbjct: 121 ERKFMNPFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTKLQDPRIMTTLS 180
Query: 181 VLLGVDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGNDAYKKKD 240
VLLGVDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGNDAYKKKD
Sbjct: 181 VLLGVDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGNDAYKKKD 240
Query: 241 FDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIA 300
FDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIA
Sbjct: 241 FDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIA 300
Query: 301 KAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLA 360
KAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLA
Sbjct: 301 KAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLA 360
Query: 361 LEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEEC 420
LEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEEC
Sbjct: 361 LEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEEC 420
Query: 421 IQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQRCMMAQYNRHD 480
IQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQRCMMAQYNRHD
Sbjct: 421 IQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQRCMMAQYNRHD 480
Query: 481 SPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKDPQALSEHLKNPVIAQKIQKLMDVGLI 540
SPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKDPQALSEHLKNPVIAQKIQKLMDVGLI
Sbjct: 481 SPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKDPQALSEHLKNPVIAQKIQKLMDVGLI 540
Query: 541 AIR 543
AIR
Sbjct: 541 AIR 543
>gi|27262638 sperm associated antigen 1 [Homo sapiens]
Length = 926
Score = 117 bits (293), Expect = 3e-26
Identities = 122/533 (22%), Positives = 220/533 (41%), Gaps = 94/533 (17%)
Query: 8 KEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDL 67
KEKGN+A + G+ ++A+ Y+ +I P V Y+NR+ A K ++ A++D K ++L
Sbjct: 213 KEKGNEAFNSGDYEEAVMYYTRSISALP-TVVAYNNRAQAEIKLQNWNSAFQDCEKVLEL 271
Query: 68 KPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAERKFMNP 127
+P K R+A + N+ EA + L E +N K+ L +E L
Sbjct: 272 EPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERDL-------- 323
Query: 128 FNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTKLQDP-----------RIM 176
+ E+ T+T +E IE ++ G K +D
Sbjct: 324 -------KNSEAASETQTKGKRMVIQE-IENSEDEEGKSGRKHEDGGGDKKPAEPAGAAR 375
Query: 177 TTLSVLLGVDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKE-------- 228
++G + + E P P++ PE + + A
Sbjct: 376 AAQPCVMGNIQKKLTGKAEGGKRPARGAPQRGQTPEAGADKRSPRRASAAAAAGGGATGH 435
Query: 229 -------------KELGNDAYKKKDFDTALKHYDKAKEL---------DPTNMTYITNQA 266
K GN+ ++ F A Y A L D ++ Y +N+A
Sbjct: 436 PGGGQGAENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILY-SNRA 494
Query: 267 AVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARI---GNSYFKEEKY------- 316
A Y ++G+ + C + C +A+E+ + + + A AY + G +Y +
Sbjct: 495 ACYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCGL 554
Query: 317 ---KDAIHFYNKSLAEHRTPDVLKKCQQ---------------AEKILKEQ------ERL 352
D+++ ++ L E P+ +K A++++ +Q R
Sbjct: 555 QLANDSVNRLSRILMELDGPNWREKLSPIPAVPASVPLQAWHPAKEMISKQAGDSSSHRQ 614
Query: 353 AYINPDLALEE-KNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQ 411
I + + K +GN+C +Y A+ Y+E +K N K+ +Y+NRA CY KL +F+
Sbjct: 615 QGITDEKTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFE 674
Query: 412 LALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEA 464
A +DC++ +QL +K + R+A A + +K+Y K++ K + LD S EA
Sbjct: 675 EAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDPSIIEA 727
Score = 70.9 bits (172), Expect = 3e-12
Identities = 37/100 (37%), Positives = 54/100 (54%), Gaps = 1/100 (1%)
Query: 359 LALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCE 418
LA EK KGNE F GDY +A+ +YT +I P Y+NRA KL + A +DCE
Sbjct: 208 LATREKEKGNEAFNSGDYEEAVMYYTRSISALPT-VVAYNNRAQAEIKLQNWNSAFQDCE 266
Query: 419 ECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLD 458
+ ++LEP +K R+A + +A + K LD++
Sbjct: 267 KVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVE 306
Score = 64.7 bits (156), Expect = 2e-10
Identities = 39/115 (33%), Positives = 58/115 (50%), Gaps = 8/115 (6%)
Query: 364 KNKGNECFQKGDYPQAMKHYTEAIKR-NPKDAK-------LYSNRAACYTKLLEFQLALK 415
K++GNE F+ G + +A Y+ AI P ++ LYSNRAACY K ++
Sbjct: 449 KSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCIQ 508
Query: 416 DCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQR 470
DC ++L P +K R+A A E ++ Y KA Y+ L +D + A D R
Sbjct: 509 DCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCGLQLANDSVNR 563
Score = 62.8 bits (151), Expect = 8e-10
Identities = 77/377 (20%), Positives = 149/377 (39%), Gaps = 72/377 (19%)
Query: 7 LKEKGNKALSVGNIDDALQCYSEAIKL-DPHNH-------VLYSNRSAAYAKKGDYQKAY 58
LK +GN+ G +A YS AI L +P +LYSNR+A Y K+G+
Sbjct: 448 LKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCI 507
Query: 59 EDGCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEAR 118
+D + ++L P K R+A A E L ++ +A Y+ L+ + + + +
Sbjct: 508 QDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCGLQLANDSVNRLSRI 567
Query: 119 LAERKFMNPFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTKLQDPRIMTT 178
L E + PN +KL P + + E + + D + Q
Sbjct: 568 LME------LDGPNWREKLSPIPAVPASVPLQAWHPAKEMISKQAGDSSSHRQQ------ 615
Query: 179 LSVLLGVDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGNDAYKK 238
G DE+ +ALKE+ GN
Sbjct: 616 ---------GITDEK----------------------------TFKALKEE--GNQCVND 636
Query: 239 KDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQ 298
K++ AL Y + +++ TN+A Y + + + ++ C++A+++ N + + +
Sbjct: 637 KNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYR 696
Query: 299 IAKAYARIGNSYFKEEKYKDAIHFYNK-SLAEHRTPDVLKKCQQAEKILKEQERLAYINP 357
A A+ + N Y+ ++ NK L + + + ++ ++L +++ A N
Sbjct: 697 RALAHKGLKN-------YQKSLIDLNKVILLDPSIIEAKMELEEVTRLLNLKDKTAPFNK 749
Query: 358 D-----LALEEKNKGNE 369
+ + ++E N+G E
Sbjct: 750 EKERRKIEIQEVNEGKE 766
Score = 52.0 bits (123), Expect = 1e-06
Identities = 45/152 (29%), Positives = 71/152 (46%), Gaps = 17/152 (11%)
Query: 218 LPENKKQ--ALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDY 275
L E +K A +EKE GN+A+ D++ A+ +Y ++ PT + Y N+A + ++
Sbjct: 200 LTEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALPTVVAY-NNRAQAEIKLQNW 258
Query: 276 NKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDV 335
N + CEK +E+ N KA R +Y + K ++A +K L DV
Sbjct: 259 NSAFQDCEKVLELEPGN-------VKALLRRATTYKHQNKLREATEDLSKVL------DV 305
Query: 336 LKKCQQAEKILKEQERLAYINPDLALEEKNKG 367
A+K L E ER N + A E + KG
Sbjct: 306 EPDNDLAKKTLSEVER-DLKNSEAASETQTKG 336
>gi|27262636 sperm associated antigen 1 [Homo sapiens]
Length = 926
Score = 117 bits (293), Expect = 3e-26
Identities = 122/533 (22%), Positives = 220/533 (41%), Gaps = 94/533 (17%)
Query: 8 KEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDL 67
KEKGN+A + G+ ++A+ Y+ +I P V Y+NR+ A K ++ A++D K ++L
Sbjct: 213 KEKGNEAFNSGDYEEAVMYYTRSISALP-TVVAYNNRAQAEIKLQNWNSAFQDCEKVLEL 271
Query: 68 KPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAERKFMNP 127
+P K R+A + N+ EA + L E +N K+ L +E L
Sbjct: 272 EPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERDL-------- 323
Query: 128 FNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTKLQDP-----------RIM 176
+ E+ T+T +E IE ++ G K +D
Sbjct: 324 -------KNSEAASETQTKGKRMVIQE-IENSEDEEGKSGRKHEDGGGDKKPAEPAGAAR 375
Query: 177 TTLSVLLGVDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKE-------- 228
++G + + E P P++ PE + + A
Sbjct: 376 AAQPCVMGNIQKKLTGKAEGGKRPARGAPQRGQTPEAGADKRSPRRASAAAAAGGGATGH 435
Query: 229 -------------KELGNDAYKKKDFDTALKHYDKAKEL---------DPTNMTYITNQA 266
K GN+ ++ F A Y A L D ++ Y +N+A
Sbjct: 436 PGGGQGAENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILY-SNRA 494
Query: 267 AVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARI---GNSYFKEEKY------- 316
A Y ++G+ + C + C +A+E+ + + + A AY + G +Y +
Sbjct: 495 ACYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCGL 554
Query: 317 ---KDAIHFYNKSLAEHRTPDVLKKCQQ---------------AEKILKEQ------ERL 352
D+++ ++ L E P+ +K A++++ +Q R
Sbjct: 555 QLANDSVNRLSRILMELDGPNWREKLSPIPAVPASVPLQAWHPAKEMISKQAGDSSSHRQ 614
Query: 353 AYINPDLALEE-KNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQ 411
I + + K +GN+C +Y A+ Y+E +K N K+ +Y+NRA CY KL +F+
Sbjct: 615 QGITDEKTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFE 674
Query: 412 LALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEA 464
A +DC++ +QL +K + R+A A + +K+Y K++ K + LD S EA
Sbjct: 675 EAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDPSIIEA 727
Score = 70.9 bits (172), Expect = 3e-12
Identities = 37/100 (37%), Positives = 54/100 (54%), Gaps = 1/100 (1%)
Query: 359 LALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCE 418
LA EK KGNE F GDY +A+ +YT +I P Y+NRA KL + A +DCE
Sbjct: 208 LATREKEKGNEAFNSGDYEEAVMYYTRSISALPT-VVAYNNRAQAEIKLQNWNSAFQDCE 266
Query: 419 ECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLD 458
+ ++LEP +K R+A + +A + K LD++
Sbjct: 267 KVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVE 306
Score = 64.7 bits (156), Expect = 2e-10
Identities = 39/115 (33%), Positives = 58/115 (50%), Gaps = 8/115 (6%)
Query: 364 KNKGNECFQKGDYPQAMKHYTEAIKR-NPKDAK-------LYSNRAACYTKLLEFQLALK 415
K++GNE F+ G + +A Y+ AI P ++ LYSNRAACY K ++
Sbjct: 449 KSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCIQ 508
Query: 416 DCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQR 470
DC ++L P +K R+A A E ++ Y KA Y+ L +D + A D R
Sbjct: 509 DCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCGLQLANDSVNR 563
Score = 62.8 bits (151), Expect = 8e-10
Identities = 77/377 (20%), Positives = 149/377 (39%), Gaps = 72/377 (19%)
Query: 7 LKEKGNKALSVGNIDDALQCYSEAIKL-DPHNH-------VLYSNRSAAYAKKGDYQKAY 58
LK +GN+ G +A YS AI L +P +LYSNR+A Y K+G+
Sbjct: 448 LKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCI 507
Query: 59 EDGCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEAR 118
+D + ++L P K R+A A E L ++ +A Y+ L+ + + + +
Sbjct: 508 QDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCGLQLANDSVNRLSRI 567
Query: 119 LAERKFMNPFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTKLQDPRIMTT 178
L E + PN +KL P + + E + + D + Q
Sbjct: 568 LME------LDGPNWREKLSPIPAVPASVPLQAWHPAKEMISKQAGDSSSHRQQ------ 615
Query: 179 LSVLLGVDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGNDAYKK 238
G DE+ +ALKE+ GN
Sbjct: 616 ---------GITDEK----------------------------TFKALKEE--GNQCVND 636
Query: 239 KDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQ 298
K++ AL Y + +++ TN+A Y + + + ++ C++A+++ N + + +
Sbjct: 637 KNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYR 696
Query: 299 IAKAYARIGNSYFKEEKYKDAIHFYNK-SLAEHRTPDVLKKCQQAEKILKEQERLAYINP 357
A A+ + N Y+ ++ NK L + + + ++ ++L +++ A N
Sbjct: 697 RALAHKGLKN-------YQKSLIDLNKVILLDPSIIEAKMELEEVTRLLNLKDKTAPFNK 749
Query: 358 D-----LALEEKNKGNE 369
+ + ++E N+G E
Sbjct: 750 EKERRKIEIQEVNEGKE 766
Score = 52.0 bits (123), Expect = 1e-06
Identities = 45/152 (29%), Positives = 71/152 (46%), Gaps = 17/152 (11%)
Query: 218 LPENKKQ--ALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDY 275
L E +K A +EKE GN+A+ D++ A+ +Y ++ PT + Y N+A + ++
Sbjct: 200 LTEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALPTVVAY-NNRAQAEIKLQNW 258
Query: 276 NKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDV 335
N + CEK +E+ N KA R +Y + K ++A +K L DV
Sbjct: 259 NSAFQDCEKVLELEPGN-------VKALLRRATTYKHQNKLREATEDLSKVL------DV 305
Query: 336 LKKCQQAEKILKEQERLAYINPDLALEEKNKG 367
A+K L E ER N + A E + KG
Sbjct: 306 EPDNDLAKKTLSEVER-DLKNSEAASETQTKG 336
>gi|225735593 RNA polymerase II associated protein 3 isoform 2 [Homo
sapiens]
Length = 631
Score = 103 bits (256), Expect = 5e-22
Identities = 77/274 (28%), Positives = 130/274 (47%), Gaps = 28/274 (10%)
Query: 212 EPMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFE 271
E E+ + + ++AL KE GN +K+ +D A+ Y K + DP N TN+A+ YF
Sbjct: 120 ESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFR 179
Query: 272 KGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLA--- 328
+ C A+ + R KAY+R G + F +K ++A Y + L
Sbjct: 180 LKKFAVAESDCNLAVALNRS-------YTKAYSRRGAARFALQKLEEAKKDYERVLELEP 232
Query: 329 -EHRTPDVLKKCQQA------------EKILK--EQERL---AYINPDLALEEKNKGNEC 370
+ L+K QA + ++K E ER A N A+ EK++GN
Sbjct: 233 NNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGF 292
Query: 371 FQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKG 430
F++G Y +A++ YT I + +A L +NRA Y K+ +++ A KDC + I L+ ++ K
Sbjct: 293 FKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKA 352
Query: 431 YTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEA 464
+ R+ A + +A ++ L L+ K+A
Sbjct: 353 FARRGTARTFLGKLNEAKQDFETVLLLEPGNKQA 386
Score = 83.2 bits (204), Expect = 6e-16
Identities = 57/163 (34%), Positives = 83/163 (50%), Gaps = 12/163 (7%)
Query: 7 LKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVD 66
LKEKGNK G D+A+ CY++ + DP+N VL +NR++AY + + A D V
Sbjct: 136 LKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVA 195
Query: 67 LKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAERKFMN 126
L + K YSR+ AA L + EEAK+ YE L+ E NN + L+ + LA ++
Sbjct: 196 LNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQALASKE--- 252
Query: 127 PFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTK 169
N Y K E+D + S R+ IE +NK + K
Sbjct: 253 -----NSYPK-EAD---IVIKSTEGERKQIEAQQNKQQAISEK 286
Score = 82.4 bits (202), Expect = 1e-15
Identities = 68/262 (25%), Positives = 128/262 (48%), Gaps = 29/262 (11%)
Query: 279 RELCEKAIEVGREN-----------REDYRQIAKAYARIGNSYFKEEKYKDAIHFYN--- 324
+++ +K +E+ R+N ++R+ K A+ + +EE K+ I Y+
Sbjct: 33 KDIKQKDMELRRQNGVPEENLPPIRNGNFRKKKKGKAKESSKKTREENTKNRIKSYDYEA 92
Query: 325 -KSLAEHRTPDVLKKCQQAEKILKEQ----ERLAYINPDLALEEKNKGNECFQKGDYPQA 379
L R D L K + L ++ E +++ AL K KGN+ F++G Y +A
Sbjct: 93 WAKLDVDRILDELDKDDSTHESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEA 152
Query: 380 MKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALE 439
+ YT+ + +P + L +NRA+ Y +L +F +A DC + L ++ K Y+R+ AA
Sbjct: 153 IDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARF 212
Query: 440 AMKDYTKAMDVYQKALDLDSSCKEAADGYQRCMMAQYNRHDS-PEDVKRRAMADPEVQQI 498
A++ +A Y++ L+L+ + EA + ++ A ++ +S P++ AD ++
Sbjct: 213 ALQKLEEAKKDYERVLELEPNNFEATNELRKISQALASKENSYPKE------ADIVIK-- 264
Query: 499 MSDPAMRLILEQMQKDPQALSE 520
S R +E Q QA+SE
Sbjct: 265 -STEGERKQIEAQQNKQQAISE 285
Score = 64.7 bits (156), Expect = 2e-10
Identities = 35/117 (29%), Positives = 60/117 (51%)
Query: 2 EQVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDG 61
+Q K++GN G + A++CY+ I D N +L +NR+ AY K Y++A +D
Sbjct: 280 QQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDC 339
Query: 62 CKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEAR 118
+ + L + K ++R+ A FL + EAK+ +E L E N Q L ++ +
Sbjct: 340 TQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKK 396
Score = 50.4 bits (119), Expect = 4e-06
Identities = 64/283 (22%), Positives = 109/283 (38%), Gaps = 49/283 (17%)
Query: 29 EAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDWGKGYSRKAAALEFLNRF 88
+ I +D ++ + Y K+G Y +A + K +D P + +A+A L +F
Sbjct: 124 DGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKF 183
Query: 89 EEAKRTYEEGLKHEANNPQLKEGLQNMEARLAERKFMNPFNMPNLYQKLESDPRT--RTL 146
A+ + L N K + AR A QKLE + R L
Sbjct: 184 AVAES--DCNLAVALNRSYTKAYSRRGAARFA-------------LQKLEEAKKDYERVL 228
Query: 147 LSDPTYRELIEQLRNKPSDLGTKLQDPRIMTTLSVLLGVDLGSMDEEEEIATPPPPPPPK 206
+P E +LR L +K S +E +I
Sbjct: 229 ELEPNNFEATNELRKISQALASKEN-----------------SYPKEADIVI-------- 263
Query: 207 KETKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQA 266
K T+ E + + +NK+QA+ EK+ GN +K+ ++ A++ Y + D N N+A
Sbjct: 264 KSTEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRA 323
Query: 267 AVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNS 309
Y + Y + + C +AI + +KA+AR G +
Sbjct: 324 MAYLKIQKYEEAEKDCTQAILLD-------GSYSKAFARRGTA 359
>gi|225735591 RNA polymerase II associated protein 3 isoform 1 [Homo
sapiens]
Length = 665
Score = 103 bits (256), Expect = 5e-22
Identities = 77/274 (28%), Positives = 130/274 (47%), Gaps = 28/274 (10%)
Query: 212 EPMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFE 271
E E+ + + ++AL KE GN +K+ +D A+ Y K + DP N TN+A+ YF
Sbjct: 120 ESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFR 179
Query: 272 KGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLA--- 328
+ C A+ + R KAY+R G + F +K ++A Y + L
Sbjct: 180 LKKFAVAESDCNLAVALNRS-------YTKAYSRRGAARFALQKLEEAKKDYERVLELEP 232
Query: 329 -EHRTPDVLKKCQQA------------EKILK--EQERL---AYINPDLALEEKNKGNEC 370
+ L+K QA + ++K E ER A N A+ EK++GN
Sbjct: 233 NNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGF 292
Query: 371 FQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKG 430
F++G Y +A++ YT I + +A L +NRA Y K+ +++ A KDC + I L+ ++ K
Sbjct: 293 FKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKA 352
Query: 431 YTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEA 464
+ R+ A + +A ++ L L+ K+A
Sbjct: 353 FARRGTARTFLGKLNEAKQDFETVLLLEPGNKQA 386
Score = 83.2 bits (204), Expect = 6e-16
Identities = 57/163 (34%), Positives = 83/163 (50%), Gaps = 12/163 (7%)
Query: 7 LKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVD 66
LKEKGNK G D+A+ CY++ + DP+N VL +NR++AY + + A D V
Sbjct: 136 LKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVA 195
Query: 67 LKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAERKFMN 126
L + K YSR+ AA L + EEAK+ YE L+ E NN + L+ + LA ++
Sbjct: 196 LNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQALASKE--- 252
Query: 127 PFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTK 169
N Y K E+D + S R+ IE +NK + K
Sbjct: 253 -----NSYPK-EAD---IVIKSTEGERKQIEAQQNKQQAISEK 286
Score = 82.4 bits (202), Expect = 1e-15
Identities = 68/262 (25%), Positives = 128/262 (48%), Gaps = 29/262 (11%)
Query: 279 RELCEKAIEVGREN-----------REDYRQIAKAYARIGNSYFKEEKYKDAIHFYN--- 324
+++ +K +E+ R+N ++R+ K A+ + +EE K+ I Y+
Sbjct: 33 KDIKQKDMELRRQNGVPEENLPPIRNGNFRKKKKGKAKESSKKTREENTKNRIKSYDYEA 92
Query: 325 -KSLAEHRTPDVLKKCQQAEKILKEQ----ERLAYINPDLALEEKNKGNECFQKGDYPQA 379
L R D L K + L ++ E +++ AL K KGN+ F++G Y +A
Sbjct: 93 WAKLDVDRILDELDKDDSTHESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEA 152
Query: 380 MKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALE 439
+ YT+ + +P + L +NRA+ Y +L +F +A DC + L ++ K Y+R+ AA
Sbjct: 153 IDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARF 212
Query: 440 AMKDYTKAMDVYQKALDLDSSCKEAADGYQRCMMAQYNRHDS-PEDVKRRAMADPEVQQI 498
A++ +A Y++ L+L+ + EA + ++ A ++ +S P++ AD ++
Sbjct: 213 ALQKLEEAKKDYERVLELEPNNFEATNELRKISQALASKENSYPKE------ADIVIK-- 264
Query: 499 MSDPAMRLILEQMQKDPQALSE 520
S R +E Q QA+SE
Sbjct: 265 -STEGERKQIEAQQNKQQAISE 285
Score = 70.9 bits (172), Expect = 3e-12
Identities = 44/165 (26%), Positives = 81/165 (49%), Gaps = 7/165 (4%)
Query: 2 EQVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDG 61
+Q K++GN G + A++CY+ I D N +L +NR+ AY K Y++A +D
Sbjct: 280 QQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDC 339
Query: 62 CKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAE 121
+ + L + K ++R+ A FL + EAK+ +E L E N Q L ++ L E
Sbjct: 340 TQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELIE 399
Query: 122 R-----KFMNPFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRN 161
+ F++ N+ + +++ P + + P + +IE+ N
Sbjct: 400 KGHWDDVFLDSTQRQNVVKPIDNPPHPGS--TKPLKKVIIEETGN 442
Score = 50.4 bits (119), Expect = 4e-06
Identities = 64/283 (22%), Positives = 109/283 (38%), Gaps = 49/283 (17%)
Query: 29 EAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDWGKGYSRKAAALEFLNRF 88
+ I +D ++ + Y K+G Y +A + K +D P + +A+A L +F
Sbjct: 124 DGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKF 183
Query: 89 EEAKRTYEEGLKHEANNPQLKEGLQNMEARLAERKFMNPFNMPNLYQKLESDPRT--RTL 146
A+ + L N K + AR A QKLE + R L
Sbjct: 184 AVAES--DCNLAVALNRSYTKAYSRRGAARFA-------------LQKLEEAKKDYERVL 228
Query: 147 LSDPTYRELIEQLRNKPSDLGTKLQDPRIMTTLSVLLGVDLGSMDEEEEIATPPPPPPPK 206
+P E +LR L +K S +E +I
Sbjct: 229 ELEPNNFEATNELRKISQALASKEN-----------------SYPKEADIVI-------- 263
Query: 207 KETKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQA 266
K T+ E + + +NK+QA+ EK+ GN +K+ ++ A++ Y + D N N+A
Sbjct: 264 KSTEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRA 323
Query: 267 AVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNS 309
Y + Y + + C +AI + +KA+AR G +
Sbjct: 324 MAYLKIQKYEEAEKDCTQAILLD-------GSYSKAFARRGTA 359
>gi|24308141 small glutamine-rich tetratricopeptide repeat
(TPR)-containing, beta [Homo sapiens]
Length = 304
Score = 89.0 bits (219), Expect = 1e-17
Identities = 52/160 (32%), Positives = 86/160 (53%), Gaps = 8/160 (5%)
Query: 3 QVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGC 62
+ ++LK++GN + N A+ CY++AI+LDP+N V Y NR+AA +K G Y A +D
Sbjct: 84 KADQLKDEGNNHMKEENYAAAVDCYTQAIELDPNNAVYYCNRAAAQSKLGHYTDAIKDCE 143
Query: 63 KTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAER 122
K + + + K Y R AL LN+FEEA +Y++ L + N K L+ E +L R
Sbjct: 144 KAIAIDSKYSKAYGRMGLALTALNKFEEAVTSYQKALDLDPENDSYKSNLKIAEQKL--R 201
Query: 123 KFMNP------FNMPNLYQKLESDPRTRTLLSDPTYRELI 156
+ +P F+M +L +L+ +P ++L+
Sbjct: 202 EVSSPTGTGLSFDMASLINNPAFISMAASLMQNPQVQQLM 241
Score = 78.6 bits (192), Expect = 1e-14
Identities = 51/154 (33%), Positives = 80/154 (51%), Gaps = 17/154 (11%)
Query: 364 KNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQL 423
K++GN ++ +Y A+ YT+AI+ +P +A Y NRAA +KL + A+KDCE+ I +
Sbjct: 89 KDEGNNHMKEENYAAAVDCYTQAIELDPNNAVYYCNRAAAQSKLGHYTDAIKDCEKAIAI 148
Query: 424 EPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLD-------SSCKEAADGYQRCM---- 472
+ + K Y R AL A+ + +A+ YQKALDLD S+ K A +
Sbjct: 149 DSKYSKAYGRMGLALTALNKFEEAVTSYQKALDLDPENDSYKSNLKIAEQKLREVSSPTG 208
Query: 473 ------MAQYNRHDSPEDVKRRAMADPEVQQIMS 500
MA + + + M +P+VQQ+MS
Sbjct: 209 TGLSFDMASLINNPAFISMAASLMQNPQVQQLMS 242
Score = 65.5 bits (158), Expect = 1e-10
Identities = 37/115 (32%), Positives = 63/115 (54%), Gaps = 7/115 (6%)
Query: 213 PMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEK 272
P+ +PE+ +A + K+ GN+ K++++ A+ Y +A ELDP N Y N+AA +
Sbjct: 73 PLSNSVPEDVGKADQLKDEGNNHMKEENYAAAVDCYTQAIELDPNNAVYYCNRAAAQSKL 132
Query: 273 GDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSL 327
G Y + CEKAI + + +KAY R+G + K+++A+ Y K+L
Sbjct: 133 GHYTDAIKDCEKAIAID-------SKYSKAYGRMGLALTALNKFEEAVTSYQKAL 180
Score = 35.4 bits (80), Expect = 0.13
Identities = 26/119 (21%), Positives = 49/119 (41%), Gaps = 26/119 (21%)
Query: 307 GNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNK 366
GN++ KEE Y A+ Y +++ ++P+ A+ N+
Sbjct: 92 GNNHMKEENYAAAVDCYTQAIE--------------------------LDPNNAVYYCNR 125
Query: 367 GNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEP 425
+ G Y A+K +AI + K +K Y T L +F+ A+ ++ + L+P
Sbjct: 126 AAAQSKLGHYTDAIKDCEKAIAIDSKYSKAYGRMGLALTALNKFEEAVTSYQKALDLDP 184
>gi|54607135 translocase of outer mitochondrial membrane 70 homolog
A [Homo sapiens]
Length = 608
Score = 87.8 bits (216), Expect = 2e-17
Identities = 109/493 (22%), Positives = 193/493 (39%), Gaps = 91/493 (18%)
Query: 1 MEQVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHN-----HVLYSNRSAAYAKKGDYQ 55
+++ K KGNK G + A+QCY+EAI L P Y NR+AA+ + ++
Sbjct: 111 LDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWK 170
Query: 56 KAYEDGCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNM 115
+ +D K V+L P + K R+A A E L+ +E + + EG QN
Sbjct: 171 EVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKEC--------LEDVTAVCILEGFQNQ 222
Query: 116 EARLAERKFMNPFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTKLQDPRI 175
++ L K + +K ++ L+ P + I
Sbjct: 223 QSMLLADKVLKLLGKEKAKEKYKN---REPLMPSPQF----------------------I 257
Query: 176 MTTLSVLLGVDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGNDA 235
+ S ++I + P K E +ED + + +AL+ KE N
Sbjct: 258 KSYFSSF----------TDDIISQP-------MLKGEKSDED-KDKEGEALEVKE--NSG 297
Query: 236 YKKKDFDTALKHYDK-----AKELDPTN---MTYITNQAAVYFEKGDYNKCRELCEKAIE 287
Y K ++YDK +KE+D + +A Y G+ N + +K I
Sbjct: 298 YLKAKQYMEEENYDKIISECSKEIDAEGKYMAEALLLRATFYLLIGNANAAKPDLDKVIS 357
Query: 288 VGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSL--------AEHRTPDVLKKC 339
+ N + A A + G+ Y ++++ + +N + H +
Sbjct: 358 LKEAN---VKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILL 414
Query: 340 QQAEKILKEQERLAYINPDLALEEKNKGNECF----------QKGDYPQAMKHYTEAIKR 389
Q E+ + + + + P+ AL + K CF AMK + E IK+
Sbjct: 415 DQVEEAVADFDECIRLRPESALAQAQK---CFALYRQAYTGNNSSQIQAAMKGFEEVIKK 471
Query: 390 NPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKA-AALEAMKDYTKAM 448
P+ A+ Y+ A T +F A + ++CI LEP Y K L+ +D + +
Sbjct: 472 FPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGL 531
Query: 449 DVYQKALDLDSSC 461
++ KA+++D+ C
Sbjct: 532 ELISKAIEIDNKC 544
>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
Length = 2481
Score = 84.7 bits (208), Expect = 2e-16
Identities = 47/136 (34%), Positives = 67/136 (49%)
Query: 6 ELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTV 65
E + N+A G+ A+ Y+EA+ +DP N +LYSNRSAAY K Y KA +D K
Sbjct: 60 EKVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKAR 119
Query: 66 DLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAERKFM 125
L P W K Y R+ AL++L R +A + GL + + QL G+ + R +
Sbjct: 120 LLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSL 179
Query: 126 NPFNMPNLYQKLESDP 141
P KL+ P
Sbjct: 180 EPTYQQLQKMKLDKSP 195
Score = 57.8 bits (138), Expect = 3e-08
Identities = 30/98 (30%), Positives = 52/98 (53%)
Query: 361 LEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEEC 420
+E+ + N+ GD+ A+ Y EA+ +P++ LYSNR+A Y K+ ++ AL D +
Sbjct: 59 VEKVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKA 118
Query: 421 IQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLD 458
L P + K Y R+ AL+ + + A+ + L D
Sbjct: 119 RLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQD 156
Score = 43.5 bits (101), Expect = 5e-04
Identities = 51/230 (22%), Positives = 94/230 (40%), Gaps = 33/230 (14%)
Query: 263 TNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHF 322
+N ++ KGDY+ +L + + + +E DY +AY +GN+Y Y A+ +
Sbjct: 478 SNLGIIHQMKGDYDTALKLHKTHLCIAQE-LSDYAAQGRAYGNMGNAYNALGMYDQAVKY 536
Query: 323 YNKSL----------AEHRTPDVLKKCQQA----EKILKEQERLAYINPDL------ALE 362
+ + L ++ T L QA ++ L+ + I +L A
Sbjct: 537 HRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARA 596
Query: 363 EKNKGNECFQKGDYPQAMKHYTEAIKRNPK------DAKLYSNRAACYTKLLEFQLALKD 416
N GN +G+Y QA +Y + ++ P + K+ N + L +Q A+K
Sbjct: 597 LSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKY 656
Query: 417 CEECIQLEPTF------IKGYTRKAAALEAMKDYTKAMDVYQKALDLDSS 460
E+ + L K Y A +A+ +++KA + + L L S
Sbjct: 657 YEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQS 706
Score = 42.0 bits (97), Expect = 0.001
Identities = 49/226 (21%), Positives = 95/226 (42%), Gaps = 33/226 (14%)
Query: 264 NQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFY 323
N AVY GD+ + E+ +++ ++ + R+ A+AY+ +G++Y + A+ ++
Sbjct: 359 NMGAVYIAMGDFENAVQCHEQHLKIAKD-LGNKREEARAYSNLGSAYHYRRNFDKAMSYH 417
Query: 324 N--KSLAEHRTPDVLK-----------KCQQ----AEKILKEQERLAYINPDLALE---E 363
N LA+ ++ +C Q A++ ++Q +A D A E
Sbjct: 418 NYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRAS 477
Query: 364 KNKGNECFQKGDYPQAMK-HYT-----EAIKRNPKDAKLYSNRAACYTKLLEFQLALKDC 417
N G KGDY A+K H T + + + Y N Y L + A+K
Sbjct: 478 SNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYH 537
Query: 418 EECIQL------EPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDL 457
+ +Q+ + + A A +A+ + +A+ YQ L++
Sbjct: 538 RQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNI 583
Score = 38.1 bits (87), Expect = 0.021
Identities = 36/159 (22%), Positives = 65/159 (40%), Gaps = 34/159 (21%)
Query: 198 TPPPPPPP-----------KKETKPEPMEEDLPE----------------NKKQALKEKE 230
+PPP P P ++E + P +P +K + +++
Sbjct: 4 SPPPAPEPTQGPTPARSRRRREPESPPASAPIPLFGADTIGQRSPDGPVLSKAEFVEKVR 63
Query: 231 LGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGR 290
N A DF TA+ Y++A +DP N +N++A Y + Y +KA++
Sbjct: 64 QSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQY-------DKALDDAI 116
Query: 291 ENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAE 329
+ R + KAY R G + ++ DA+ + LA+
Sbjct: 117 KARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQ 155
Score = 37.0 bits (84), Expect = 0.046
Identities = 66/312 (21%), Positives = 116/312 (37%), Gaps = 46/312 (14%)
Query: 264 NQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFY 323
N ++ K D N + E+ + + + + D R A AYA +G +Y +KY A+ ++
Sbjct: 719 NLGDIFICKKDINGAIKFYEQQLGLAHQVK-DRRLEASAYAALGTAYRMIQKYDKALGYH 777
Query: 324 NKSLAEHRTPD-----------------VLKKCQQAEKILKEQERLAYINPDLALEEKNK 366
+ L ++ L K A K +EQ L D +LE +
Sbjct: 778 TQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVY 837
Query: 367 GNECFQK----------GDYPQ--AMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLAL 414
GN K G + Q AM + + Y N CY L +++ A+
Sbjct: 838 GNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAI 897
Query: 415 KDCEECIQLEPTF------IKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAAD-- 466
K E+ + + + K Y AM +A+ ++K L + EA +
Sbjct: 898 KYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKA 957
Query: 467 ------GYQRCMMAQYNRHDSPEDVKRRAMADPEVQQIMSDPAMRL--ILEQMQKDPQAL 518
G + Y + S + + D + + + SD A L + +QM + AL
Sbjct: 958 QAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTAL 1017
Query: 519 SEHLKNPVIAQK 530
H + IA++
Sbjct: 1018 QYHQLDLQIAEE 1029
Score = 36.2 bits (82), Expect = 0.079
Identities = 67/318 (21%), Positives = 127/318 (39%), Gaps = 58/318 (18%)
Query: 165 DLGTKLQDPRIMTTLSVLLGVDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQ 224
DLG KL+DP + + +G+ +M+ EE + M + L N+
Sbjct: 822 DLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAI--------GYFEQQLAMLQQLSGNESV 873
Query: 225 ALKEKELGN--DAYKK-KDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRE- 280
+ + GN D Y+ D++ A+K+Y++ + ++ + +QA Y G+ ++
Sbjct: 874 LDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSV-AQSLNRMQDQAKAYRGLGNGHRAMGS 932
Query: 281 -----LC-EKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPD 334
+C EK + V E E + + A+AY +G+ + + Y+ AI
Sbjct: 933 LQQALVCFEKRLVVAHELGEAFNK-AQAYGELGSLHSQLGNYEQAI-------------- 977
Query: 335 VLKKCQQAEKILKEQERLAYINPDLALEEK---NKGNECFQKGDYPQAMKHYTEAIK--- 388
L+ Q +A D ALE G Q G+Y A++++ ++
Sbjct: 978 ---------SCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQIAE 1028
Query: 389 --RNPK-DAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTF------IKGYTRKAAALE 439
NP + Y N Y L F+ A+ E+ + + Y+
Sbjct: 1029 ETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHH 1088
Query: 440 AMKDYTKAMDVYQKALDL 457
A+++Y++A+ Q+ L L
Sbjct: 1089 ALQNYSQAVMYLQEGLRL 1106
>gi|225735595 RNA polymerase II associated protein 3 isoform 3 [Homo
sapiens]
Length = 506
Score = 82.0 bits (201), Expect = 1e-15
Identities = 64/233 (27%), Positives = 108/233 (46%), Gaps = 28/233 (12%)
Query: 253 ELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFK 312
+ DP N TN+A+ YF + C A+ + R KAY+R G + F
Sbjct: 2 DADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRS-------YTKAYSRRGAARFA 54
Query: 313 EEKYKDAIHFYNKSLA----EHRTPDVLKKCQQA------------EKILK--EQERL-- 352
+K ++A Y + L + L+K QA + ++K E ER
Sbjct: 55 LQKLEEAKKDYERVLELEPNNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQI 114
Query: 353 -AYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQ 411
A N A+ EK++GN F++G Y +A++ YT I + +A L +NRA Y K+ +++
Sbjct: 115 EAQQNKQQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYE 174
Query: 412 LALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEA 464
A KDC + I L+ ++ K + R+ A + +A ++ L L+ K+A
Sbjct: 175 EAEKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQA 227
Score = 70.9 bits (172), Expect = 3e-12
Identities = 44/165 (26%), Positives = 81/165 (49%), Gaps = 7/165 (4%)
Query: 2 EQVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDG 61
+Q K++GN G + A++CY+ I D N +L +NR+ AY K Y++A +D
Sbjct: 121 QQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDC 180
Query: 62 CKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAE 121
+ + L + K ++R+ A FL + EAK+ +E L E N Q L ++ L E
Sbjct: 181 TQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELIE 240
Query: 122 R-----KFMNPFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRN 161
+ F++ N+ + +++ P + + P + +IE+ N
Sbjct: 241 KGHWDDVFLDSTQRQNVVKPIDNPPHPGS--TKPLKKVIIEETGN 283
Score = 57.0 bits (136), Expect = 4e-08
Identities = 45/136 (33%), Positives = 66/136 (48%), Gaps = 12/136 (8%)
Query: 34 DPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKR 93
DP+N VL +NR++AY + + A D V L + K YSR+ AA L + EEAK+
Sbjct: 4 DPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKK 63
Query: 94 TYEEGLKHEANNPQLKEGLQNMEARLAERKFMNPFNMPNLYQKLESDPRTRTLLSDPTYR 153
YE L+ E NN + L+ + LA ++ N Y K E+D + S R
Sbjct: 64 DYERVLELEPNNFEATNELRKISQALASKE--------NSYPK-EAD---IVIKSTEGER 111
Query: 154 ELIEQLRNKPSDLGTK 169
+ IE +NK + K
Sbjct: 112 KQIEAQQNKQQAISEK 127
Score = 52.0 bits (123), Expect = 1e-06
Identities = 37/132 (28%), Positives = 69/132 (52%), Gaps = 10/132 (7%)
Query: 390 NPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMD 449
+P + L +NRA+ Y +L +F +A DC + L ++ K Y+R+ AA A++ +A
Sbjct: 4 DPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKK 63
Query: 450 VYQKALDLDSSCKEAADGYQRCMMAQYNRHDS-PEDVKRRAMADPEVQQIMSDPAMRLIL 508
Y++ L+L+ + EA + ++ A ++ +S P++ AD ++ S R +
Sbjct: 64 DYERVLELEPNNFEATNELRKISQALASKENSYPKE------ADIVIK---STEGERKQI 114
Query: 509 EQMQKDPQALSE 520
E Q QA+SE
Sbjct: 115 EAQQNKQQAISE 126
Score = 47.4 bits (111), Expect = 3e-05
Identities = 28/103 (27%), Positives = 51/103 (49%), Gaps = 7/103 (6%)
Query: 207 KETKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQA 266
K T+ E + + +NK+QA+ EK+ GN +K+ ++ A++ Y + D N N+A
Sbjct: 105 KSTEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRA 164
Query: 267 AVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNS 309
Y + Y + + C +AI + +KA+AR G +
Sbjct: 165 MAYLKIQKYEEAEKDCTQAILLD-------GSYSKAFARRGTA 200
>gi|4506921 small glutamine-rich tetratricopeptide [Homo sapiens]
Length = 313
Score = 80.9 bits (198), Expect = 3e-15
Identities = 42/119 (35%), Positives = 68/119 (57%)
Query: 3 QVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGC 62
+ LK +GN+ + V N + A+ Y +AI+L+P N V + NR+AAY+K G+Y A +D
Sbjct: 90 EAERLKTEGNEQMKVENFEAAVHFYGKAIELNPANAVYFCNRAAAYSKLGNYAGAVQDCE 149
Query: 63 KTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAE 121
+ + + P + K Y R AL LN+ EA Y++ L+ + +N K L+ E +L E
Sbjct: 150 RAICIDPAYSKAYGRMGLALSSLNKHVEAVAYYKKALELDPDNETYKSNLKIAELKLRE 208
Score = 74.7 bits (182), Expect = 2e-13
Identities = 41/153 (26%), Positives = 80/153 (52%), Gaps = 5/153 (3%)
Query: 364 KNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQL 423
K +GNE + ++ A+ Y +AI+ NP +A + NRAA Y+KL + A++DCE I +
Sbjct: 95 KTEGNEQMKVENFEAAVHFYGKAIELNPANAVYFCNRAAAYSKLGNYAGAVQDCERAICI 154
Query: 424 EPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQRCMMAQYNRHDSPE 483
+P + K Y R AL ++ + +A+ Y+KAL+LD + + +A+ ++P
Sbjct: 155 DPAYSKAYGRMGLALSSLNKHVEAVAYYKKALELDPDNETYKSNLK---IAELKLREAPS 211
Query: 484 DVKRRAMADPEVQQIMSDPAMRLILEQMQKDPQ 516
+ ++ ++++P + + +PQ
Sbjct: 212 PT--GGVGSFDIAGLLNNPGFMSMASNLMNNPQ 242
Score = 65.5 bits (158), Expect = 1e-10
Identities = 41/126 (32%), Positives = 64/126 (50%), Gaps = 11/126 (8%)
Query: 202 PPPPKKETKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTY 261
P + + P EED E A + K GN+ K ++F+ A+ Y KA EL+P N Y
Sbjct: 72 PQDLRSPARTPPSEEDSAE----AERLKTEGNEQMKVENFEAAVHFYGKAIELNPANAVY 127
Query: 262 ITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIH 321
N+AA Y + G+Y + CE+AI + +KAY R+G + K+ +A+
Sbjct: 128 FCNRAAAYSKLGNYAGAVQDCERAICID-------PAYSKAYGRMGLALSSLNKHVEAVA 180
Query: 322 FYNKSL 327
+Y K+L
Sbjct: 181 YYKKAL 186
>gi|221219056 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform 2
[Homo sapiens]
Length = 438
Score = 79.3 bits (194), Expect = 8e-15
Identities = 59/245 (24%), Positives = 110/245 (44%), Gaps = 25/245 (10%)
Query: 220 ENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCR 279
+N ++ +++ ++K+DF + D+A E P + +A G Y + +
Sbjct: 81 KNANAVMEYEKIAETDFEKRDFRKVVFCMDRALEFAPACHRFKILKAECLAMLGRYPEAQ 140
Query: 280 ELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKC 339
+ + + N + Y R G + E+ + A+ F+ ++L PD K C
Sbjct: 141 SVASDILRMDSTNAD------ALYVR-GLCLYYEDCIEKAVQFFVQAL--RMAPDHEKAC 191
Query: 340 QQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKD----AK 395
+A N +K GN+ F++G+Y A + YTEA+ +P + AK
Sbjct: 192 ------------IACRNAKALKAKKEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTNAK 239
Query: 396 LYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKAL 455
LY NR +KL + A++DC ++L+ T+IK Y R+A + Y +A+ Y+K
Sbjct: 240 LYCNRGTVNSKLRKLDDAIEDCTNAVKLDDTYIKAYLRRAQCYMDTEQYEEAVRDYEKVY 299
Query: 456 DLDSS 460
+ +
Sbjct: 300 QTEKT 304
Score = 65.5 bits (158), Expect = 1e-10
Identities = 82/363 (22%), Positives = 147/363 (40%), Gaps = 22/363 (6%)
Query: 35 PHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRT 94
P N Y NR+A G +++A D ++V L + +G+ R+ L A R+
Sbjct: 3 PKNASYYGNRAATLMMLGRFREALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMAACRS 62
Query: 95 YEEGLKHEANNPQLKEGLQNMEA-----RLAERKFMN------PFNMPNLYQKLESDPRT 143
++ L+ + N Q ++ +N A ++AE F F M + + R
Sbjct: 63 FQRALELDHKNAQAQQEFKNANAVMEYEKIAETDFEKRDFRKVVFCMDRALEFAPACHRF 122
Query: 144 RTLLSDPTYRELIEQLRNKPSDLGTKLQDPRIMTTLSVLLGVDLGSMDEEEEIATPPPPP 203
+ L + E + L P R+ +T + L V + E+ I
Sbjct: 123 KILKA-----ECLAMLGRYPEAQSVASDILRMDSTNADALYVRGLCLYYEDCIEKAVQFF 177
Query: 204 PPKKETKPEPMEEDLPENKKQALK-EKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYI 262
P+ + + +ALK +KE GN A+K+ ++ A + Y +A +DP N I
Sbjct: 178 VQALRMAPDHEKACIACRNAKALKAKKEDGNKAFKEGNYKLAYELYTEALGIDPNN---I 234
Query: 263 TNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHF 322
A +Y +G N + AIE + KAY R Y E+Y++A+
Sbjct: 235 KTNAKLYCNRGTVNSKLRKLDDAIEDCTNAVKLDDTYIKAYLRRAQCYMDTEQYEEAVRD 294
Query: 323 YNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKH 382
Y K +T + + + A+ LK+ +R Y + +KN + +K +A+ H
Sbjct: 295 YEKVYQTEKTKEHKQLLKNAQLELKKSKRKDYYK--ILGVDKNASEDEIKKAYRKRALMH 352
Query: 383 YTE 385
+ +
Sbjct: 353 HPD 355
Score = 60.8 bits (146), Expect = 3e-09
Identities = 54/187 (28%), Positives = 83/187 (44%), Gaps = 18/187 (9%)
Query: 8 KEKGNKALSVGNIDDALQCYSEAIKLDPHN----HVLYSNRSAAYAKKGDYQKAYEDGCK 63
KE GNKA GN A + Y+EA+ +DP+N LY NR +K A ED
Sbjct: 204 KEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTNAKLYCNRGTVNSKLRKLDDAIEDCTN 263
Query: 64 TVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAERK 123
V L + K Y R+A ++EEA R YE+ + E + K+ L+N + L + K
Sbjct: 264 AVKLDDTYIKAYLRRAQCYMDTEQYEEAVRDYEKVYQTE-KTKEHKQLLKNAQLELKKSK 322
Query: 124 FMNPFNMPNLYQKLESDP-----RTRTLLSDP-----TYRELIEQLRNKPSDLG---TKL 170
+ + + + + D R R L+ P E+ ++ K ++G T L
Sbjct: 323 RKDYYKILGVDKNASEDEIKKAYRKRALMHHPDRHSGASAEVQKEEEKKFKEVGEAFTIL 382
Query: 171 QDPRIMT 177
DP+ T
Sbjct: 383 SDPKKKT 389
Score = 48.5 bits (114), Expect = 2e-05
Identities = 26/98 (26%), Positives = 50/98 (51%)
Query: 391 PKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDV 450
PK+A Y NRAA L F+ AL D ++ ++L+ +F++G+ R+ ++ + A
Sbjct: 3 PKNASYYGNRAATLMMLGRFREALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMAACRS 62
Query: 451 YQKALDLDSSCKEAADGYQRCMMAQYNRHDSPEDVKRR 488
+Q+AL+LD +A ++ + D ++R
Sbjct: 63 FQRALELDHKNAQAQQEFKNANAVMEYEKIAETDFEKR 100
Score = 32.0 bits (71), Expect = 1.5
Identities = 46/228 (20%), Positives = 87/228 (38%), Gaps = 25/228 (10%)
Query: 256 PTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEK 315
P N +Y N+AA G + + ++++ + + + K + +GN+
Sbjct: 3 PKNASYYGNRAATLMMLGRFREALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMAACRS 62
Query: 316 YKDAIHFYNKSLAEHRTPDVLKKCQQAEKIL-----KEQERLAYINPDLALE-------E 363
++ A+ +K+ + + EKI K R D ALE
Sbjct: 63 FQRALELDHKNAQAQQEFKNANAVMEYEKIAETDFEKRDFRKVVFCMDRALEFAPACHRF 122
Query: 364 KNKGNECF-QKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQ 422
K EC G YP+A ++ ++ + +A R C + A++ + ++
Sbjct: 123 KILKAECLAMLGRYPEAQSVASDILRMDSTNADALYVRGLCLYYEDCIEKAVQFFVQALR 182
Query: 423 LEPTFIKG--YTRKAAALEAMKD----------YTKAMDVYQKALDLD 458
+ P K R A AL+A K+ Y A ++Y +AL +D
Sbjct: 183 MAPDHEKACIACRNAKALKAKKEDGNKAFKEGNYKLAYELYTEALGID 230
>gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform 1
[Homo sapiens]
Length = 494
Score = 79.3 bits (194), Expect = 8e-15
Identities = 59/245 (24%), Positives = 110/245 (44%), Gaps = 25/245 (10%)
Query: 220 ENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCR 279
+N ++ +++ ++K+DF + D+A E P + +A G Y + +
Sbjct: 137 KNANAVMEYEKIAETDFEKRDFRKVVFCMDRALEFAPACHRFKILKAECLAMLGRYPEAQ 196
Query: 280 ELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKC 339
+ + + N + Y R G + E+ + A+ F+ ++L PD K C
Sbjct: 197 SVASDILRMDSTNAD------ALYVR-GLCLYYEDCIEKAVQFFVQAL--RMAPDHEKAC 247
Query: 340 QQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKD----AK 395
+A N +K GN+ F++G+Y A + YTEA+ +P + AK
Sbjct: 248 ------------IACRNAKALKAKKEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTNAK 295
Query: 396 LYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKAL 455
LY NR +KL + A++DC ++L+ T+IK Y R+A + Y +A+ Y+K
Sbjct: 296 LYCNRGTVNSKLRKLDDAIEDCTNAVKLDDTYIKAYLRRAQCYMDTEQYEEAVRDYEKVY 355
Query: 456 DLDSS 460
+ +
Sbjct: 356 QTEKT 360
Score = 78.2 bits (191), Expect = 2e-14
Identities = 89/395 (22%), Positives = 164/395 (41%), Gaps = 22/395 (5%)
Query: 3 QVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGC 62
+ KE+GN + + ++A Y++AI + P N Y NR+A G +++A D
Sbjct: 27 EAETFKEQGNAYYAKKDYNEAYNYYTKAIDMCPKNASYYGNRAATLMMLGRFREALGDAQ 86
Query: 63 KTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEA----- 117
++V L + +G+ R+ L A R+++ L+ + N Q ++ +N A
Sbjct: 87 QSVRLDDSFVRGHLREGKCHLSLGNAMAACRSFQRALELDHKNAQAQQEFKNANAVMEYE 146
Query: 118 RLAERKFMN------PFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTKLQ 171
++AE F F M + + R + L + E + L P
Sbjct: 147 KIAETDFEKRDFRKVVFCMDRALEFAPACHRFKILKA-----ECLAMLGRYPEAQSVASD 201
Query: 172 DPRIMTTLSVLLGVDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALK-EKE 230
R+ +T + L V + E+ I P+ + + +ALK +KE
Sbjct: 202 ILRMDSTNADALYVRGLCLYYEDCIEKAVQFFVQALRMAPDHEKACIACRNAKALKAKKE 261
Query: 231 LGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGR 290
GN A+K+ ++ A + Y +A +DP N I A +Y +G N + AIE
Sbjct: 262 DGNKAFKEGNYKLAYELYTEALGIDPNN---IKTNAKLYCNRGTVNSKLRKLDDAIEDCT 318
Query: 291 ENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQE 350
+ KAY R Y E+Y++A+ Y K +T + + + A+ L++ +
Sbjct: 319 NAVKLDDTYIKAYLRRAQCYMDTEQYEEAVRDYEKVYQTEKTKEHKQLLKNAQLELRKSK 378
Query: 351 RLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTE 385
R Y + +KN + +K +A+ H+ +
Sbjct: 379 RKDYYK--ILGVDKNASEDEIKKAYRKRALMHHPD 411
Score = 69.3 bits (168), Expect = 8e-12
Identities = 37/125 (29%), Positives = 66/125 (52%)
Query: 364 KNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQL 423
K +GN + K DY +A +YT+AI PK+A Y NRAA L F+ AL D ++ ++L
Sbjct: 32 KEQGNAYYAKKDYNEAYNYYTKAIDMCPKNASYYGNRAATLMMLGRFREALGDAQQSVRL 91
Query: 424 EPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQRCMMAQYNRHDSPE 483
+ +F++G+ R+ ++ + A +Q+AL+LD +A ++ +
Sbjct: 92 DDSFVRGHLREGKCHLSLGNAMAACRSFQRALELDHKNAQAQQEFKNANAVMEYEKIAET 151
Query: 484 DVKRR 488
D ++R
Sbjct: 152 DFEKR 156
Score = 61.2 bits (147), Expect = 2e-09
Identities = 64/275 (23%), Positives = 116/275 (42%), Gaps = 27/275 (9%)
Query: 209 TKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAV 268
T+PE +++ E K++A KE GN Y KKD++ A +Y KA ++ P N +Y N+AA
Sbjct: 14 TEPELLDDQ--EAKREAETFKEQGNAYYAKKDYNEAYNYYTKAIDMCPKNASYYGNRAAT 71
Query: 269 YFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLA 328
G + + ++++ + + + K + +GN+ ++ A+ +K+
Sbjct: 72 LMMLGRFREALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMAACRSFQRALELDHKNAQ 131
Query: 329 EHRTPDVLKKCQQAEKIL-----KEQERLAYINPDLALE-------EKNKGNECF-QKGD 375
+ + EKI K R D ALE K EC G
Sbjct: 132 AQQEFKNANAVMEYEKIAETDFEKRDFRKVVFCMDRALEFAPACHRFKILKAECLAMLGR 191
Query: 376 YPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKG--YTR 433
YP+A ++ ++ + +A R C + A++ + +++ P K R
Sbjct: 192 YPEAQSVASDILRMDSTNADALYVRGLCLYYEDCIEKAVQFFVQALRMAPDHEKACIACR 251
Query: 434 KAAALEAMKD----------YTKAMDVYQKALDLD 458
A AL+A K+ Y A ++Y +AL +D
Sbjct: 252 NAKALKAKKEDGNKAFKEGNYKLAYELYTEALGID 286
Score = 60.8 bits (146), Expect = 3e-09
Identities = 54/187 (28%), Positives = 83/187 (44%), Gaps = 18/187 (9%)
Query: 8 KEKGNKALSVGNIDDALQCYSEAIKLDPHN----HVLYSNRSAAYAKKGDYQKAYEDGCK 63
KE GNKA GN A + Y+EA+ +DP+N LY NR +K A ED
Sbjct: 260 KEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTNAKLYCNRGTVNSKLRKLDDAIEDCTN 319
Query: 64 TVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAERK 123
V L + K Y R+A ++EEA R YE+ + E + K+ L+N + L + K
Sbjct: 320 AVKLDDTYIKAYLRRAQCYMDTEQYEEAVRDYEKVYQTE-KTKEHKQLLKNAQLELRKSK 378
Query: 124 FMNPFNMPNLYQKLESDP-----RTRTLLSDP-----TYRELIEQLRNKPSDLG---TKL 170
+ + + + + D R R L+ P E+ ++ K ++G T L
Sbjct: 379 RKDYYKILGVDKNASEDEIKKAYRKRALMHHPDRHSGASAEVQKEEEKKFKEVGEAFTIL 438
Query: 171 QDPRIMT 177
DP+ T
Sbjct: 439 SDPKKKT 445
>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
Length = 1036
Score = 79.0 bits (193), Expect = 1e-14
Identities = 61/258 (23%), Positives = 114/258 (44%), Gaps = 1/258 (0%)
Query: 231 LGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGR 290
LGN + + FD A+ Y +A L P + N A VY+E+G + + +AIE+
Sbjct: 221 LGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQP 280
Query: 291 ENREDYRQIAKAYARIGNSYFKEEKYKDAIHFY-NKSLAEHRTPDVLKKCQQAEKILKEQ 349
+ Y +A A G+ E+ Y A+ + + + ++ ++ E+ ++
Sbjct: 281 HFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLY 340
Query: 350 ERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLE 409
+ + P+ A N + Q+G +A+ HY EAI+ +P A YSN ++ +
Sbjct: 341 RKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQD 400
Query: 410 FQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQ 469
Q AL+ IQ+ P F ++ A+ + + +A+ Y+ AL L +A
Sbjct: 401 VQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLA 460
Query: 470 RCMMAQYNRHDSPEDVKR 487
C+ + D E +K+
Sbjct: 461 HCLQIVCDWTDYDERMKK 478
Score = 76.6 bits (187), Expect = 5e-14
Identities = 96/423 (22%), Positives = 163/423 (38%), Gaps = 30/423 (7%)
Query: 30 AIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDWGKGYSRKAAALEFLNRFE 89
AIK +P YSN Y ++G Q+A E + LKPD+ GY AAAL E
Sbjct: 71 AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME 130
Query: 90 EAKRTYEEGLKHEANNPQLKEGLQNM---EARLAERKFMNPFNMPNLYQKLESDPRTRTL 146
A + Y L++ + ++ L N+ RL E K + +E+ P
Sbjct: 131 GAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKAC-------YLKAIETQPNFAVA 183
Query: 147 LSDPTYRELIEQLRNKPSDLGTKLQDPRIMTTLS---VLLGVDLGSMDEEEEIATPPPPP 203
S+ + + N ++ + TL + ++LG++ +E I
Sbjct: 184 WSN------LGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIF------ 231
Query: 204 PPKKETKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYIT 263
+ L + A+ L Y++ D A+ Y +A EL P
Sbjct: 232 ----DRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYC 287
Query: 264 NQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFY 323
N A EKG + + A+ + + + +A GN Y+ A+ +
Sbjct: 288 NLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVF 347
Query: 324 NKSLAEH-RTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKH 382
+ A H VL++ + ++ L + I+P A N GN + D A++
Sbjct: 348 PEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQC 407
Query: 383 YTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMK 442
YT AI+ NP A +SN A+ + A+ ++L+P F Y A L+ +
Sbjct: 408 YTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVC 467
Query: 443 DYT 445
D+T
Sbjct: 468 DWT 470
Score = 72.0 bits (175), Expect = 1e-12
Identities = 72/308 (23%), Positives = 123/308 (39%), Gaps = 23/308 (7%)
Query: 230 ELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVG 289
EL + Y+ DF+ A +H + +P N + ++++F+ CR L +++
Sbjct: 16 ELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQ------CRRL-DRSAHFS 68
Query: 290 RENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPD----------VLKKC 339
+ +A+AY+ +GN Y + + ++AI Y +L PD L
Sbjct: 69 TLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHAL--RLKPDFIDGYINLAAALVAA 126
Query: 340 QQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSN 399
E ++ NPDL + GN G +A Y +AI+ P A +SN
Sbjct: 127 GDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSN 186
Query: 400 RAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDS 459
+ E LA+ E+ + L+P F+ Y L+ + + +A+ Y +AL L S
Sbjct: 187 LGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSL-S 245
Query: 460 SCKEAADGYQRCMMAQYNRHDSPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKDPQALS 519
G C+ + D D RRA+ E+Q D L +K A +
Sbjct: 246 PNHAVVHGNLACVYYEQGLIDLAIDTYRRAI---ELQPHFPDAYCNLANALKEKGSVAEA 302
Query: 520 EHLKNPVI 527
E N +
Sbjct: 303 EDCYNTAL 310
Score = 57.0 bits (136), Expect = 4e-08
Identities = 68/308 (22%), Positives = 118/308 (38%), Gaps = 9/308 (2%)
Query: 218 LPENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNK 277
+ +N A LGN ++ A++HY A L P + N AA GD
Sbjct: 72 IKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEG 131
Query: 278 CRELCEKAIEVGREN---REDYRQIAKAYARIGNSYFKEEKYKDAIHFY-NKSLAEHRTP 333
+ A++ + R D + KA R+ + + Y AI N ++A
Sbjct: 132 AVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEA---KACYLKAIETQPNFAVAWSNLG 188
Query: 334 DVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKD 393
V + + E+ ++P+ N GN + + +A+ Y A+ +P
Sbjct: 189 CVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNH 248
Query: 394 AKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQK 453
A ++ N A Y + LA+ I+L+P F Y A AL+ +A D Y
Sbjct: 249 AVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNT 308
Query: 454 ALDLDSSCKEAADGYQRCMMAQYNRHDSPEDVKRRAMADPEVQQIMSDPAMRLILEQMQK 513
AL L + ++ + Q N ++ ++ PE S+ A +L+Q K
Sbjct: 309 ALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLAS--VLQQQGK 366
Query: 514 DPQALSEH 521
+AL +
Sbjct: 367 LQEALMHY 374
Score = 51.2 bits (121), Expect = 2e-06
Identities = 79/393 (20%), Positives = 134/393 (34%), Gaps = 84/393 (21%)
Query: 11 GNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPD 70
GN ++G +++A CY +AI+ P+ V +SN + +G+ A K V L P+
Sbjct: 154 GNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPN 213
Query: 71 WGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAERKFMNPFNM 130
+ Y L+ F+ A Y L N+ + N+ E+ ++
Sbjct: 214 FLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVH---GNLACVYYEQGLID---- 266
Query: 131 PNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTKLQDPRIMTTLSVLLGVDLGSM 190
L D R + P + + L N + G+ + T L S+
Sbjct: 267 ------LAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSL 320
Query: 191 DEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDK 250
+ I ++E GN + A++ Y K
Sbjct: 321 NNLANI-------------------------------KREQGN-------IEEAVRLYRK 342
Query: 251 AKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSY 310
A E+ P +N A+V ++G + ++AI + A AY+ +GN+
Sbjct: 343 ALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRIS-------PTFADAYSNMGNT- 394
Query: 311 FKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNEC 370
LK+ Q + L+ R INP A N +
Sbjct: 395 -------------------------LKEMQDVQGALQCYTRAIQINPAFADAHSNLASIH 429
Query: 371 FQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAAC 403
G+ P+A+ Y A+K P Y N A C
Sbjct: 430 KDSGNIPEAIASYRTALKLKPDFPDAYCNLAHC 462
Score = 42.7 bits (99), Expect = 8e-04
Identities = 30/117 (25%), Positives = 58/117 (49%), Gaps = 10/117 (8%)
Query: 5 NELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKT 64
N LKEKG+ A +A CY+ A++L P + +N + ++G+ ++A K
Sbjct: 291 NALKEKGSVA-------EAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKA 343
Query: 65 VDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAE 121
+++ P++ +S A+ L+ + +EA Y+E ++ +P + NM L E
Sbjct: 344 LEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIR---ISPTFADAYSNMGNTLKE 397
Score = 40.8 bits (94), Expect = 0.003
Identities = 24/90 (26%), Positives = 45/90 (50%), Gaps = 4/90 (4%)
Query: 11 GNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPD 70
GN + ++ ALQCY+ AI+++P +SN ++ + G+ +A + LKPD
Sbjct: 392 GNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 451
Query: 71 WGKGYSRKAAALEFLNRFEEAKRTYEEGLK 100
+ Y A L+ + + + Y+E +K
Sbjct: 452 FPDAYCNLAHCLQIVCDWTD----YDERMK 477
Score = 40.0 bits (92), Expect = 0.005
Identities = 27/94 (28%), Positives = 42/94 (44%)
Query: 11 GNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPD 70
GN G + +A++ Y A++L P Y N +AA GD + A + + PD
Sbjct: 86 GNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPD 145
Query: 71 WGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEAN 104
S L+ L R EEAK Y + ++ + N
Sbjct: 146 LYCVRSDLGNLLKALGRLEEAKACYLKAIETQPN 179
Score = 37.7 bits (86), Expect = 0.027
Identities = 23/111 (20%), Positives = 50/111 (45%), Gaps = 3/111 (2%)
Query: 5 NELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKT 64
+ L N GNI++A++ Y +A+++ P +SN ++ ++G Q+A +
Sbjct: 318 DSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEA 377
Query: 65 VDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNM 115
+ + P + YS L+ + + A + Y ++ NP + N+
Sbjct: 378 IRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQ---INPAFADAHSNL 425
>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
Length = 1046
Score = 79.0 bits (193), Expect = 1e-14
Identities = 61/258 (23%), Positives = 114/258 (44%), Gaps = 1/258 (0%)
Query: 231 LGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGR 290
LGN + + FD A+ Y +A L P + N A VY+E+G + + +AIE+
Sbjct: 231 LGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQP 290
Query: 291 ENREDYRQIAKAYARIGNSYFKEEKYKDAIHFY-NKSLAEHRTPDVLKKCQQAEKILKEQ 349
+ Y +A A G+ E+ Y A+ + + + ++ ++ E+ ++
Sbjct: 291 HFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLY 350
Query: 350 ERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLE 409
+ + P+ A N + Q+G +A+ HY EAI+ +P A YSN ++ +
Sbjct: 351 RKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQD 410
Query: 410 FQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQ 469
Q AL+ IQ+ P F ++ A+ + + +A+ Y+ AL L +A
Sbjct: 411 VQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLA 470
Query: 470 RCMMAQYNRHDSPEDVKR 487
C+ + D E +K+
Sbjct: 471 HCLQIVCDWTDYDERMKK 488
Score = 76.6 bits (187), Expect = 5e-14
Identities = 96/423 (22%), Positives = 163/423 (38%), Gaps = 30/423 (7%)
Query: 30 AIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDWGKGYSRKAAALEFLNRFE 89
AIK +P YSN Y ++G Q+A E + LKPD+ GY AAAL E
Sbjct: 81 AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME 140
Query: 90 EAKRTYEEGLKHEANNPQLKEGLQNM---EARLAERKFMNPFNMPNLYQKLESDPRTRTL 146
A + Y L++ + ++ L N+ RL E K + +E+ P
Sbjct: 141 GAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKAC-------YLKAIETQPNFAVA 193
Query: 147 LSDPTYRELIEQLRNKPSDLGTKLQDPRIMTTLS---VLLGVDLGSMDEEEEIATPPPPP 203
S+ + + N ++ + TL + ++LG++ +E I
Sbjct: 194 WSN------LGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIF------ 241
Query: 204 PPKKETKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYIT 263
+ L + A+ L Y++ D A+ Y +A EL P
Sbjct: 242 ----DRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYC 297
Query: 264 NQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFY 323
N A EKG + + A+ + + + +A GN Y+ A+ +
Sbjct: 298 NLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVF 357
Query: 324 NKSLAEH-RTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKH 382
+ A H VL++ + ++ L + I+P A N GN + D A++
Sbjct: 358 PEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQC 417
Query: 383 YTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMK 442
YT AI+ NP A +SN A+ + A+ ++L+P F Y A L+ +
Sbjct: 418 YTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVC 477
Query: 443 DYT 445
D+T
Sbjct: 478 DWT 480
Score = 72.0 bits (175), Expect = 1e-12
Identities = 72/308 (23%), Positives = 123/308 (39%), Gaps = 23/308 (7%)
Query: 230 ELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVG 289
EL + Y+ DF+ A +H + +P N + ++++F+ CR L +++
Sbjct: 26 ELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQ------CRRL-DRSAHFS 78
Query: 290 RENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPD----------VLKKC 339
+ +A+AY+ +GN Y + + ++AI Y +L PD L
Sbjct: 79 TLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHAL--RLKPDFIDGYINLAAALVAA 136
Query: 340 QQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSN 399
E ++ NPDL + GN G +A Y +AI+ P A +SN
Sbjct: 137 GDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSN 196
Query: 400 RAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDS 459
+ E LA+ E+ + L+P F+ Y L+ + + +A+ Y +AL L S
Sbjct: 197 LGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSL-S 255
Query: 460 SCKEAADGYQRCMMAQYNRHDSPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKDPQALS 519
G C+ + D D RRA+ E+Q D L +K A +
Sbjct: 256 PNHAVVHGNLACVYYEQGLIDLAIDTYRRAI---ELQPHFPDAYCNLANALKEKGSVAEA 312
Query: 520 EHLKNPVI 527
E N +
Sbjct: 313 EDCYNTAL 320
Score = 57.0 bits (136), Expect = 4e-08
Identities = 68/308 (22%), Positives = 118/308 (38%), Gaps = 9/308 (2%)
Query: 218 LPENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNK 277
+ +N A LGN ++ A++HY A L P + N AA GD
Sbjct: 82 IKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEG 141
Query: 278 CRELCEKAIEVGREN---REDYRQIAKAYARIGNSYFKEEKYKDAIHFY-NKSLAEHRTP 333
+ A++ + R D + KA R+ + + Y AI N ++A
Sbjct: 142 AVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEA---KACYLKAIETQPNFAVAWSNLG 198
Query: 334 DVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKD 393
V + + E+ ++P+ N GN + + +A+ Y A+ +P
Sbjct: 199 CVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNH 258
Query: 394 AKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQK 453
A ++ N A Y + LA+ I+L+P F Y A AL+ +A D Y
Sbjct: 259 AVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNT 318
Query: 454 ALDLDSSCKEAADGYQRCMMAQYNRHDSPEDVKRRAMADPEVQQIMSDPAMRLILEQMQK 513
AL L + ++ + Q N ++ ++ PE S+ A +L+Q K
Sbjct: 319 ALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLAS--VLQQQGK 376
Query: 514 DPQALSEH 521
+AL +
Sbjct: 377 LQEALMHY 384
Score = 51.2 bits (121), Expect = 2e-06
Identities = 79/393 (20%), Positives = 134/393 (34%), Gaps = 84/393 (21%)
Query: 11 GNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPD 70
GN ++G +++A CY +AI+ P+ V +SN + +G+ A K V L P+
Sbjct: 164 GNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPN 223
Query: 71 WGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAERKFMNPFNM 130
+ Y L+ F+ A Y L N+ + N+ E+ ++
Sbjct: 224 FLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVH---GNLACVYYEQGLID---- 276
Query: 131 PNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTKLQDPRIMTTLSVLLGVDLGSM 190
L D R + P + + L N + G+ + T L S+
Sbjct: 277 ------LAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSL 330
Query: 191 DEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDK 250
+ I ++E GN + A++ Y K
Sbjct: 331 NNLANI-------------------------------KREQGN-------IEEAVRLYRK 352
Query: 251 AKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSY 310
A E+ P +N A+V ++G + ++AI + A AY+ +GN+
Sbjct: 353 ALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRIS-------PTFADAYSNMGNT- 404
Query: 311 FKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNEC 370
LK+ Q + L+ R INP A N +
Sbjct: 405 -------------------------LKEMQDVQGALQCYTRAIQINPAFADAHSNLASIH 439
Query: 371 FQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAAC 403
G+ P+A+ Y A+K P Y N A C
Sbjct: 440 KDSGNIPEAIASYRTALKLKPDFPDAYCNLAHC 472
Score = 42.7 bits (99), Expect = 8e-04
Identities = 30/117 (25%), Positives = 58/117 (49%), Gaps = 10/117 (8%)
Query: 5 NELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKT 64
N LKEKG+ A +A CY+ A++L P + +N + ++G+ ++A K
Sbjct: 301 NALKEKGSVA-------EAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKA 353
Query: 65 VDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAE 121
+++ P++ +S A+ L+ + +EA Y+E ++ +P + NM L E
Sbjct: 354 LEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIR---ISPTFADAYSNMGNTLKE 407
Score = 40.8 bits (94), Expect = 0.003
Identities = 24/90 (26%), Positives = 45/90 (50%), Gaps = 4/90 (4%)
Query: 11 GNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPD 70
GN + ++ ALQCY+ AI+++P +SN ++ + G+ +A + LKPD
Sbjct: 402 GNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 461
Query: 71 WGKGYSRKAAALEFLNRFEEAKRTYEEGLK 100
+ Y A L+ + + + Y+E +K
Sbjct: 462 FPDAYCNLAHCLQIVCDWTD----YDERMK 487
Score = 40.0 bits (92), Expect = 0.005
Identities = 27/94 (28%), Positives = 42/94 (44%)
Query: 11 GNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPD 70
GN G + +A++ Y A++L P Y N +AA GD + A + + PD
Sbjct: 96 GNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPD 155
Query: 71 WGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEAN 104
S L+ L R EEAK Y + ++ + N
Sbjct: 156 LYCVRSDLGNLLKALGRLEEAKACYLKAIETQPN 189
Score = 37.7 bits (86), Expect = 0.027
Identities = 23/111 (20%), Positives = 50/111 (45%), Gaps = 3/111 (2%)
Query: 5 NELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKT 64
+ L N GNI++A++ Y +A+++ P +SN ++ ++G Q+A +
Sbjct: 328 DSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEA 387
Query: 65 VDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNM 115
+ + P + YS L+ + + A + Y ++ NP + N+
Sbjct: 388 IRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQ---INPAFADAHSNL 435
>gi|90669931 tetratricopeptide repeat domain 12 [Homo sapiens]
Length = 705
Score = 79.0 bits (193), Expect = 1e-14
Identities = 47/167 (28%), Positives = 83/167 (49%), Gaps = 7/167 (4%)
Query: 343 EKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAA 402
EK KE+ + N LA K KGNE F +G+Y A+ Y+E +++ LY+NRA
Sbjct: 89 EKDAKERAKRRRENKVLADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQ 148
Query: 403 CYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCK 462
Y KL +++ AL DCE ++ + K Y A A+K+Y+ + + Y+K L+++ +
Sbjct: 149 AYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKANLALKNYSVSRECYKKILEINPKLQ 208
Query: 463 EAADGY-------QRCMMAQYNRHDSPEDVKRRAMADPEVQQIMSDP 502
GY ++ + + H+ + K A+ + + +S P
Sbjct: 209 TQVKGYLNQVDLQEKADLQEKEAHELLDSGKNTAVTTKNLLETLSKP 255
Score = 53.1 bits (126), Expect = 6e-07
Identities = 35/103 (33%), Positives = 53/103 (51%), Gaps = 3/103 (2%)
Query: 7 LKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVD 66
LKEKGN+A + GN + A+ YSE ++ VLY+NR+ AY K DY+KA D +
Sbjct: 109 LKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALK 168
Query: 67 LKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLK 109
K Y A L + ++ Y++ L+ NP+L+
Sbjct: 169 CDEKCTKAYFHMGKANLALKNYSVSRECYKKILE---INPKLQ 208
Score = 50.1 bits (118), Expect = 5e-06
Identities = 50/207 (24%), Positives = 87/207 (42%), Gaps = 13/207 (6%)
Query: 122 RKFM-NPFNMPNLYQKLESDPRTRTLLSDPTYRE-LIEQLRNKPSDLGTKLQDPRIMTTL 179
+KF+ N + NL Q++ SD DP ++ + + + + ++ TTL
Sbjct: 10 QKFLKNVDEISNLIQEMNSD--------DPVVQQKAVLETEKRLLLMEEDQEEDECRTTL 61
Query: 180 S-VLLGVDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGNDAYKK 238
+ ++ +M EEI + +K+ K ENK A KE GN+A+ +
Sbjct: 62 NKTMISPPQTAMKSAEEINSEAFLASVEKDAKERAKRRR--ENKVLADALKEKGNEAFAE 119
Query: 239 KDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQ 298
+++TA+ Y + E TN+A Y + DY K CE A++ + + Y
Sbjct: 120 GNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFH 179
Query: 299 IAKAYARIGNSYFKEEKYKDAIHFYNK 325
+ KA + N E YK + K
Sbjct: 180 MGKANLALKNYSVSRECYKKILEINPK 206
>gi|5453958 protein phosphatase 5, catalytic subunit [Homo sapiens]
Length = 499
Score = 73.2 bits (178), Expect = 6e-13
Identities = 39/112 (34%), Positives = 62/112 (55%)
Query: 360 ALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEE 419
A E K + N+ F+ DY A+K Y++AI+ NP +A Y NR+ Y + + AL D
Sbjct: 28 AEELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAYLRTECYGYALGDATR 87
Query: 420 CIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQRC 471
I+L+ +IKGY R+AA+ A+ + A+ Y+ + + K+A YQ C
Sbjct: 88 AIELDKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKPHDKDAKMKYQEC 139
Score = 70.1 bits (170), Expect = 5e-12
Identities = 38/124 (30%), Positives = 66/124 (53%)
Query: 1 MEQVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYED 60
+++ ELK + N + ++A++ YS+AI+L+P N + Y NRS AY + Y A D
Sbjct: 25 LKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAYLRTECYGYALGD 84
Query: 61 GCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLA 120
+ ++L + KGY R+AA+ L +F A R YE +K + ++ K Q +
Sbjct: 85 ATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKPHDKDAKMKYQECNKIVK 144
Query: 121 ERKF 124
++ F
Sbjct: 145 QKAF 148
Score = 55.8 bits (133), Expect = 1e-07
Identities = 42/159 (26%), Positives = 70/159 (44%), Gaps = 20/159 (12%)
Query: 192 EEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDKA 251
E E A PP PP K+A + K ND +K KD++ A+K Y +A
Sbjct: 7 ERTECAEPPRDEPPADGAL------------KRAEELKTQANDYFKAKDYENAIKFYSQA 54
Query: 252 KELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYF 311
EL+P+N Y N++ Y Y +AIE+ ++ + Y + A + +G
Sbjct: 55 IELNPSNAIYYGNRSLAYLRTECYGYALGDATRAIELDKKYIKGYYRRAASNMALG---- 110
Query: 312 KEEKYKDAIHFYNKSL-AEHRTPDVLKKCQQAEKILKEQ 349
K++ A+ Y + + D K Q+ KI+K++
Sbjct: 111 ---KFRAALRDYETVVKVKPHDKDAKMKYQECNKIVKQK 146
Score = 42.0 bits (97), Expect = 0.001
Identities = 31/118 (26%), Positives = 52/118 (44%), Gaps = 26/118 (22%)
Query: 308 NSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKG 367
N YFK + Y++AI FY++++ +NP A+ N+
Sbjct: 36 NDYFKAKDYENAIKFYSQAIE--------------------------LNPSNAIYYGNRS 69
Query: 368 NECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEP 425
+ Y A+ T AI+ + K K Y RAA L +F+ AL+D E ++++P
Sbjct: 70 LAYLRTECYGYALGDATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKP 127
>gi|4507711 tetratricopeptide repeat domain 1 [Homo sapiens]
Length = 292
Score = 71.2 bits (173), Expect = 2e-12
Identities = 49/166 (29%), Positives = 88/166 (53%), Gaps = 10/166 (6%)
Query: 311 FKEEKYKDAIHFYNKSLAEHRTPDVLKKCQ-QAEKILKEQERLAYINPDLALEEKNKGNE 369
F+EE D + NKS + + ++ ++ + EK + ++E+ L+E+ GNE
Sbjct: 70 FEEEPGADKVE--NKSNEDVNSSELDEEYLIELEKNMSDEEKQKRREESTRLKEE--GNE 125
Query: 370 CFQKGDYPQAMKHYTEAIKRNP-----KDAKLYSNRAACYTKLLEFQLALKDCEECIQLE 424
F+KGDY +A Y+ A++ P + + L+SNRAA K + ++A+ DC + IQL
Sbjct: 126 QFKKGDYIEAESSYSRALEMCPSCFQKERSILFSNRAAARMKQDKKEMAINDCSKAIQLN 185
Query: 425 PTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQR 470
P++I+ R+A E +A++ Y+ L+ D S +A + R
Sbjct: 186 PSYIRAILRRAELYEKTDKLDEALEDYKSILEKDPSIHQAREACMR 231
Score = 60.1 bits (144), Expect = 5e-09
Identities = 35/126 (27%), Positives = 63/126 (50%), Gaps = 5/126 (3%)
Query: 2 EQVNELKEKGNKALSVGNIDDALQCYSEAIKLDP-----HNHVLYSNRSAAYAKKGDYQK 56
E+ LKE+GN+ G+ +A YS A+++ P +L+SNR+AA K+ +
Sbjct: 114 EESTRLKEEGNEQFKKGDYIEAESSYSRALEMCPSCFQKERSILFSNRAAARMKQDKKEM 173
Query: 57 AYEDGCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNME 116
A D K + L P + + R+A E ++ +EA Y+ L+ + + Q +E +
Sbjct: 174 AINDCSKAIQLNPSYIRAILRRAELYEKTDKLDEALEDYKSILEKDPSIHQAREACMRLP 233
Query: 117 ARLAER 122
++ ER
Sbjct: 234 KQIEER 239
Score = 42.7 bits (99), Expect = 8e-04
Identities = 38/167 (22%), Positives = 77/167 (46%), Gaps = 15/167 (8%)
Query: 208 ETKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPT-----NMTYI 262
E + +E+ + ++++ + KE GN+ +KK D+ A Y +A E+ P+
Sbjct: 99 ELEKNMSDEEKQKRREESTRLKEEGNEQFKKGDYIEAESSYSRALEMCPSCFQKERSILF 158
Query: 263 TNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHF 322
+N+AA ++ C KAI++ +A R Y K +K +A+
Sbjct: 159 SNRAAARMKQDKKEMAINDCSKAIQLN-------PSYIRAILRRAELYEKTDKLDEALED 211
Query: 323 YNKSLAEHRTPDVLKKCQQAEKILKE-QERLAYINPDLALEEKNKGN 368
Y KS+ E + P + + + ++ K+ +ER + ++ + K+ GN
Sbjct: 212 Y-KSILE-KDPSIHQAREACMRLPKQIEERNERLKEEMLGKLKDLGN 256
Score = 37.4 bits (85), Expect = 0.035
Identities = 45/235 (19%), Positives = 93/235 (39%), Gaps = 37/235 (15%)
Query: 192 EEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDKA 251
+E E A PP P P + ++ + + +D E L D +++ F +++
Sbjct: 24 QEAECAGPPVPDPKNQHSQSKLLRDD----------EAHLQEDQGEEECFHDCSASFEEE 73
Query: 252 KELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYF 311
D + N++ + ++ L E + E ++ R+ + GN F
Sbjct: 74 PGADK-----VENKSNEDVNSSELDE-EYLIELEKNMSDEEKQKRREESTRLKEEGNEQF 127
Query: 312 KEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECF 371
K+ Y +A Y+++L ++ C Q E+ + R A +++ K
Sbjct: 128 KKGDYIEAESSYSRAL------EMCPSCFQKERSILFSNRAA-----ARMKQDKK----- 171
Query: 372 QKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPT 426
A+ ++AI+ NP + RA Y K + AL+D + ++ +P+
Sbjct: 172 -----EMAINDCSKAIQLNPSYIRAILRRAELYEKTDKLDEALEDYKSILEKDPS 221
>gi|21361356 translocase of outer mitochondrial membrane 34 [Homo
sapiens]
Length = 309
Score = 69.7 bits (169), Expect = 6e-12
Identities = 32/95 (33%), Positives = 59/95 (62%)
Query: 364 KNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQL 423
K +GNE +KG++ +A++ Y+E++ + ++ YSNRA CY L ++ A+KDC E ++L
Sbjct: 197 KEEGNELVKKGNHKKAIEKYSESLLCSNLESATYSNRALCYLVLKQYTEAVKDCTEALKL 256
Query: 424 EPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLD 458
+ +K + R+A A +A+KDY + L ++
Sbjct: 257 DGKNVKAFYRRAQAHKALKDYKSSFADISNLLQIE 291
Score = 69.3 bits (168), Expect = 8e-12
Identities = 43/126 (34%), Positives = 63/126 (50%), Gaps = 8/126 (6%)
Query: 357 PDLALEEKNKGNECFQKGDYPQAMKHYTEAIK-------RNPKDAK-LYSNRAACYTKLL 408
PD E + GNE F+ G Y +A Y A++ +P++ LYSNRAAC+ K
Sbjct: 6 PDSVEELRAAGNESFRNGQYAEASALYGRALRVLQAQGSSDPEEESVLYSNRAACHLKDG 65
Query: 409 EFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGY 468
+ +KDC + L P IK R+A+A EA++ Y A Y+ L +D + A +G
Sbjct: 66 NCRDCIKDCTSALALVPFSIKPLLRRASAYEALEKYPMAYVDYKTVLQIDDNVTSAVEGI 125
Query: 469 QRCMMA 474
R A
Sbjct: 126 NRMTRA 131
Score = 51.6 bits (122), Expect = 2e-06
Identities = 66/310 (21%), Positives = 119/310 (38%), Gaps = 53/310 (17%)
Query: 2 EQVNELKEKGNKALSVGNIDDALQCYSEAIKL-------DPHNH-VLYSNRSAAYAKKGD 53
+ V EL+ GN++ G +A Y A+++ DP VLYSNR+A + K G+
Sbjct: 7 DSVEELRAAGNESFRNGQYAEASALYGRALRVLQAQGSSDPEEESVLYSNRAACHLKDGN 66
Query: 54 YQKAYEDGCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQ 113
+ +D + L P K R+A+A E L ++ A Y+ L+ + N EG+
Sbjct: 67 CRDCIKDCTSALALVPFSIKPLLRRASAYEALEKYPMAYVDYKTVLQIDDNVTSAVEGIN 126
Query: 114 NMEARLAERKFMNPFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTKLQDP 173
M R M+ P KL S P ++ + PS+
Sbjct: 127 RM-----TRALMDSLG-PEWRLKLPSIPLVPVSAQ--------KRWNSLPSENHK----- 167
Query: 174 RIMTTLSVLLGVDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGN 233
++ +E AT P K ++E+ GN
Sbjct: 168 ------------EMAKSKSKETTATKNRVPSAGDVEKARVLKEE--------------GN 201
Query: 234 DAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENR 293
+ KK + A++ Y ++ +N+A Y Y + + C +A+++ +N
Sbjct: 202 ELVKKGNHKKAIEKYSESLLCSNLESATYSNRALCYLVLKQYTEAVKDCTEALKLDGKNV 261
Query: 294 EDYRQIAKAY 303
+ + + A+A+
Sbjct: 262 KAFYRRAQAH 271
Score = 46.2 bits (108), Expect = 8e-05
Identities = 31/119 (26%), Positives = 56/119 (47%)
Query: 1 MEQVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYED 60
+E+ LKE+GN+ + GN A++ YSE++ YSNR+ Y Y +A +D
Sbjct: 190 VEKARVLKEEGNELVKKGNHKKAIEKYSESLLCSNLESATYSNRALCYLVLKQYTEAVKD 249
Query: 61 GCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARL 119
+ + L K + R+A A + L ++ + L+ E N ++ Q ++ L
Sbjct: 250 CTEALKLDGKNVKAFYRRAQAHKALKDYKSSFADISNLLQIEPRNGPAQKLRQEVKQNL 308
Score = 41.6 bits (96), Expect = 0.002
Identities = 32/126 (25%), Positives = 52/126 (41%), Gaps = 26/126 (20%)
Query: 300 AKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDL 359
A+ GN K+ +K AI Y++SL C E L Y L
Sbjct: 193 ARVLKEEGNELVKKGNHKKAIEKYSESLL----------CSNLESATYSNRALCY----L 238
Query: 360 ALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEE 419
L++ Y +A+K TEA+K + K+ K + RA + L +++ + D
Sbjct: 239 VLKQ------------YTEAVKDCTEALKLDGKNVKAFYRRAQAHKALKDYKSSFADISN 286
Query: 420 CIQLEP 425
+Q+EP
Sbjct: 287 LLQIEP 292
>gi|49640011 tetratricopeptide repeat domain 3 [Homo sapiens]
Length = 2025
Score = 67.0 bits (162), Expect = 4e-11
Identities = 53/165 (32%), Positives = 80/165 (48%), Gaps = 7/165 (4%)
Query: 330 HRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKR 389
H T V++ C E+ LK Q + I + K KGNE F K + A+ +YT AI+
Sbjct: 204 HITKIVMEDCNLLEE-LKTQSCMDCIEEGELM--KMKGNEEFSKERFDIAIIYYTRAIEY 260
Query: 390 NPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMD 449
P++ LY NRA C+ + +F+ AL D + L+ T+ KG+ R AL + +Y A+
Sbjct: 261 RPENYLLYGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQ 320
Query: 450 VYQKALDLDSSCKEAADGYQRCMMAQYNRHDSPEDVK-RRAMADP 493
KA L CK +G + + ED++ R A DP
Sbjct: 321 ANIKAQKL---CKNDPEGIKDLIQQHVKLQKQIEDLQGRTANKDP 362
Score = 65.1 bits (157), Expect = 2e-10
Identities = 44/172 (25%), Positives = 81/172 (47%), Gaps = 16/172 (9%)
Query: 1 MEQVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYED 60
+E+ +K KGN+ S D A+ Y+ AI+ P N++LY NR+ + + G ++ A D
Sbjct: 228 IEEGELMKMKGNEEFSKERFDIAIIYYTRAIEYRPENYLLYGNRALCFLRTGQFRNALGD 287
Query: 61 GCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQ-----------LK 109
G + LK W KG+ R AL L ++ A + + K N+P+ L+
Sbjct: 288 GKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQ 347
Query: 110 EGLQNMEARLAERKFMNPFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRN 161
+ +++++ R A + + F Y+ PR+ + T +E+ R+
Sbjct: 348 KQIEDLQGRTANKDPIKAF-----YENRAYTPRSLSAPIFTTSLNFVEKERD 394
Score = 34.3 bits (77), Expect = 0.30
Identities = 19/66 (28%), Positives = 33/66 (50%), Gaps = 4/66 (6%)
Query: 214 MEEDLPENKKQALKEKEL----GNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVY 269
+EE ++ ++E EL GN+ + K+ FD A+ +Y +A E P N N+A +
Sbjct: 216 LEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRAIEYRPENYLLYGNRALCF 275
Query: 270 FEKGDY 275
G +
Sbjct: 276 LRTGQF 281
Score = 30.0 bits (66), Expect = 5.6
Identities = 40/160 (25%), Positives = 68/160 (42%), Gaps = 27/160 (16%)
Query: 144 RTLLSDPTYRELIEQLRNKPSDLGTKLQ---DPRIMTTLSVL----------LGVDLGSM 190
R+L+ D Y L+EQ + T+L DP+ + L++ L + L +
Sbjct: 491 RSLIQDG-YMALLEQRCRSAAQAFTELLNGLDPQKIKQLNLAMINYVLVVYGLAISLLGI 549
Query: 191 DEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDK 250
+ EE++ + E + + + E P L +G KK F AL H++K
Sbjct: 550 GQPEELS--------EAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEK 601
Query: 251 AKELD---PTNMTYITNQAAVYFEKGDYNKCRELCEKAIE 287
A+ L P +T+ T+ V E+ K + L EK +E
Sbjct: 602 ARTLIYRLPGVLTWPTSN--VIIEESQPQKIKMLLEKFVE 639
>gi|49640009 tetratricopeptide repeat domain 3 [Homo sapiens]
Length = 2025
Score = 67.0 bits (162), Expect = 4e-11
Identities = 53/165 (32%), Positives = 80/165 (48%), Gaps = 7/165 (4%)
Query: 330 HRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKR 389
H T V++ C E+ LK Q + I + K KGNE F K + A+ +YT AI+
Sbjct: 204 HITKIVMEDCNLLEE-LKTQSCMDCIEEGELM--KMKGNEEFSKERFDIAIIYYTRAIEY 260
Query: 390 NPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMD 449
P++ LY NRA C+ + +F+ AL D + L+ T+ KG+ R AL + +Y A+
Sbjct: 261 RPENYLLYGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQ 320
Query: 450 VYQKALDLDSSCKEAADGYQRCMMAQYNRHDSPEDVK-RRAMADP 493
KA L CK +G + + ED++ R A DP
Sbjct: 321 ANIKAQKL---CKNDPEGIKDLIQQHVKLQKQIEDLQGRTANKDP 362
Score = 65.1 bits (157), Expect = 2e-10
Identities = 44/172 (25%), Positives = 81/172 (47%), Gaps = 16/172 (9%)
Query: 1 MEQVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYED 60
+E+ +K KGN+ S D A+ Y+ AI+ P N++LY NR+ + + G ++ A D
Sbjct: 228 IEEGELMKMKGNEEFSKERFDIAIIYYTRAIEYRPENYLLYGNRALCFLRTGQFRNALGD 287
Query: 61 GCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQ-----------LK 109
G + LK W KG+ R AL L ++ A + + K N+P+ L+
Sbjct: 288 GKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQ 347
Query: 110 EGLQNMEARLAERKFMNPFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRN 161
+ +++++ R A + + F Y+ PR+ + T +E+ R+
Sbjct: 348 KQIEDLQGRTANKDPIKAF-----YENRAYTPRSLSAPIFTTSLNFVEKERD 394
Score = 34.3 bits (77), Expect = 0.30
Identities = 19/66 (28%), Positives = 33/66 (50%), Gaps = 4/66 (6%)
Query: 214 MEEDLPENKKQALKEKEL----GNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVY 269
+EE ++ ++E EL GN+ + K+ FD A+ +Y +A E P N N+A +
Sbjct: 216 LEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRAIEYRPENYLLYGNRALCF 275
Query: 270 FEKGDY 275
G +
Sbjct: 276 LRTGQF 281
Score = 30.0 bits (66), Expect = 5.6
Identities = 40/160 (25%), Positives = 68/160 (42%), Gaps = 27/160 (16%)
Query: 144 RTLLSDPTYRELIEQLRNKPSDLGTKLQ---DPRIMTTLSVL----------LGVDLGSM 190
R+L+ D Y L+EQ + T+L DP+ + L++ L + L +
Sbjct: 491 RSLIQDG-YMALLEQRCRSAAQAFTELLNGLDPQKIKQLNLAMINYVLVVYGLAISLLGI 549
Query: 191 DEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDK 250
+ EE++ + E + + + E P L +G KK F AL H++K
Sbjct: 550 GQPEELS--------EAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEK 601
Query: 251 AKELD---PTNMTYITNQAAVYFEKGDYNKCRELCEKAIE 287
A+ L P +T+ T+ V E+ K + L EK +E
Sbjct: 602 ARTLIYRLPGVLTWPTSN--VIIEESQPQKIKMLLEKFVE 639
>gi|56181387 STIP1 homology and U-box containing protein 1 [Homo
sapiens]
Length = 303
Score = 64.3 bits (155), Expect = 3e-10
Identities = 47/157 (29%), Positives = 74/157 (47%), Gaps = 8/157 (5%)
Query: 360 ALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEE 419
A E K +GN F YP+A Y AI RNP A Y+NRA CY K+ + + AL DC
Sbjct: 26 AQELKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYYTNRALCYLKMQQHEQALADCRR 85
Query: 420 CIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDL--DSSCKEAADGYQRCMMAQYN 477
++L+ +K + M+ Y +A+ Q+A L + D +A+
Sbjct: 86 ALELDGQSVKAHFFLGQCQLEMESYDEAIANLQRAYSLAKEQRLNFGDDIPSALRIAKKK 145
Query: 478 RHDSPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKD 514
R +S E+ RR + E+ +S RLI + +++
Sbjct: 146 RWNSIEE--RRIHQESELHSYLS----RLIAAERERE 176
Score = 50.8 bits (120), Expect = 3e-06
Identities = 47/167 (28%), Positives = 73/167 (43%), Gaps = 14/167 (8%)
Query: 6 ELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTV 65
ELKE+GN+ +A CY AI +P V Y+NR+ Y K +++A D + +
Sbjct: 28 ELKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYYTNRALCYLKMQQHEQALADCRRAL 87
Query: 66 DLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQL-KEGLQNM------EAR 118
+L G S KA FL + + +Y+E + + L KE N R
Sbjct: 88 EL-----DGQSVKAHF--FLGQCQLEMESYDEAIANLQRAYSLAKEQRLNFGDDIPSALR 140
Query: 119 LAERKFMNPFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSD 165
+A++K N ++Q+ E L++ REL E RN D
Sbjct: 141 IAKKKRWNSIEERRIHQESELHSYLSRLIAAERERELEECQRNHEGD 187
Score = 44.3 bits (103), Expect = 3e-04
Identities = 40/168 (23%), Positives = 71/168 (42%), Gaps = 23/168 (13%)
Query: 219 PENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKC 278
PE A + KE GN + + + A Y +A +P Y TN+A Y + + +
Sbjct: 20 PEKSPSAQELKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYYTNRALCYLKMQQHEQA 79
Query: 279 RELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNK--SLAEHR----- 331
C +A+E+ Q KA+ +G + E Y +AI + SLA+ +
Sbjct: 80 LADCRRALELD-------GQSVKAHFFLGQCQLEMESYDEAIANLQRAYSLAKEQRLNFG 132
Query: 332 --TPDVLKKCQ-------QAEKILKEQERLAYINPDLALEEKNKGNEC 370
P L+ + + +I +E E +Y++ +A E + + EC
Sbjct: 133 DDIPSALRIAKKKRWNSIEERRIHQESELHSYLSRLIAAERERELEEC 180
>gi|73747840 LON peptidase N-terminal domain and ring finger 3
isoform 1 [Homo sapiens]
Length = 759
Score = 63.5 bits (153), Expect = 5e-10
Identities = 34/93 (36%), Positives = 53/93 (56%)
Query: 3 QVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGC 62
+ ++L+ +GN+ ++ AL Y+EA+KL P++H+LYSNRS Y ++ A D
Sbjct: 242 RASQLRHEGNRLYRERQVEAALLKYNEAVKLAPNDHLLYSNRSQIYFTLESHENALHDAE 301
Query: 63 KTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTY 95
L+P K + RKA AL L + EEA R +
Sbjct: 302 IACKLRPMGFKAHFRKAQALATLGKVEEALREF 334
Score = 60.1 bits (144), Expect = 5e-09
Identities = 37/114 (32%), Positives = 55/114 (48%)
Query: 357 PDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKD 416
P A + +++GN +++ A+ Y EA+K P D LYSNR+ Y L + AL D
Sbjct: 240 PARASQLRHEGNRLYRERQVEAALLKYNEAVKLAPNDHLLYSNRSQIYFTLESHENALHD 299
Query: 417 CEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQR 470
E +L P K + RKA AL + +A+ + + LD K A QR
Sbjct: 300 AEIACKLRPMGFKAHFRKAQALATLGKVEEALREFLYCVSLDGKNKRARCEAQR 353
>gi|75677570 dyslexia susceptibility 1 candidate 1 isoform a [Homo
sapiens]
Length = 420
Score = 62.0 bits (149), Expect = 1e-09
Identities = 61/221 (27%), Positives = 102/221 (46%), Gaps = 38/221 (17%)
Query: 280 ELCEKAIEVGRENRE-DYRQIAKAYA--------RIGNSYFKEEKYKDAIHFYNK--SLA 328
+LC+K ++ E ++ Y+ + + A R + F E+ +D+I S+
Sbjct: 180 KLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIK 239
Query: 329 EHRTPDV----LKKCQQAEK---ILKEQERLAYINPDLAL------EEKN------KGNE 369
+ TP V L++ Q AE+ + K+ E +N D+A EEKN KGN+
Sbjct: 240 INFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNK 299
Query: 370 CFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQL------ 423
F +Y A+ Y AI+ N K LY NRAAC+ KL A++D + ++L
Sbjct: 300 LFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKALELLMPPVT 359
Query: 424 --EPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCK 462
+K + R+ A ++ Y + + Y+ AL +D S K
Sbjct: 360 DNANARMKAHVRRGTAFCQLELYVEGLQDYEAALKIDPSNK 400
Score = 49.7 bits (117), Expect = 7e-06
Identities = 34/107 (31%), Positives = 52/107 (48%), Gaps = 8/107 (7%)
Query: 7 LKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVD 66
LK+KGNK + N A+ Y+ AI+L+ +LY NR+A + K + KA ED K ++
Sbjct: 293 LKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKALE 352
Query: 67 L--------KPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANN 105
L K + R+ A L + E + YE LK + +N
Sbjct: 353 LLMPPVTDNANARMKAHVRRGTAFCQLELYVEGLQDYEAALKIDPSN 399
Score = 38.1 bits (87), Expect = 0.021
Identities = 78/345 (22%), Positives = 132/345 (38%), Gaps = 65/345 (18%)
Query: 13 KALSVGNID-DALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAY--------EDGCK 63
+ LSV +D + +Q E L + + A AK+ D + A E+ K
Sbjct: 84 ETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKK 143
Query: 64 TVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAERK 123
D+K + + A + L ++E +R EE K Q +E L E ++ E +
Sbjct: 144 IEDMKEN------ERIKATKALEAWKEYQRKAEEQKKI-----QREEKLCQKEKQIKEER 192
Query: 124 FMNPFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTKLQDPRIMTTLSVLL 183
+K++ TR L S R L + RN + KL++ I SV
Sbjct: 193 -----------KKIKYKSLTRNLAS----RNLAPKGRNSENIFTEKLKEDSIPAPRSV-- 235
Query: 184 GVDLGSMDEEEEIATPPPPPPPKKETKPEPMEE--------------------DLPENKK 223
GS+ TP P +E++ EE DL E +K
Sbjct: 236 ----GSIKIN---FTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEK 288
Query: 224 QALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCE 283
K+ GN + +++ A+ Y+ A L+ N+AA + + + +K E
Sbjct: 289 NPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSS 348
Query: 284 KAIEVGRENREDYRQI-AKAYARIGNSYFKEEKYKDAIHFYNKSL 327
KA+E+ D KA+ R G ++ + E Y + + Y +L
Sbjct: 349 KALELLMPPVTDNANARMKAHVRRGTAFCQLELYVEGLQDYEAAL 393
>gi|89179321 smooth muscle cell associated protein-1 isoform 3 [Homo
sapiens]
Length = 929
Score = 60.8 bits (146), Expect = 3e-09
Identities = 37/122 (30%), Positives = 65/122 (53%), Gaps = 3/122 (2%)
Query: 4 VNELKEKGNKALSVGNIDDALQCYSEAIKLD--PHNH-VLYSNRSAAYAKKGDYQKAYED 60
V +L+++GN+ G+ AL Y++A+ LD P + VL+ NR+A + K DY KA +
Sbjct: 6 VEQLRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAETE 65
Query: 61 GCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLA 120
K ++ K R++ ALE L R ++A + + E N +E L+N+ ++
Sbjct: 66 ASKAIEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQ 125
Query: 121 ER 122
E+
Sbjct: 126 EK 127
Score = 58.9 bits (141), Expect = 1e-08
Identities = 54/189 (28%), Positives = 91/189 (48%), Gaps = 20/189 (10%)
Query: 364 KNKGNECFQKGDYPQAMKHYTEAI--KRNPKD-AKLYSNRAACYTKLLEFQLALKDCEEC 420
+ +GNE F+ GDY A+ YT+A+ P+D A L+ NRAAC+ KL ++ A + +
Sbjct: 10 RKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAETEASKA 69
Query: 421 IQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQRC--MMAQYNR 478
I+ + +K R++ ALE + +A+ Q+ + L+ K + + + + R
Sbjct: 70 IEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEKVR 129
Query: 479 HDSPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKDPQALSEHLKNPVIAQKI------- 531
+ S D K M QI+ DP + E+ QK Q L + A+KI
Sbjct: 130 YMSSTDAKVEQMF-----QILLDPEEK-GTEKKQKASQNLVVLAREDAGAEKIFRSNGVQ 183
Query: 532 --QKLMDVG 538
Q+L+D+G
Sbjct: 184 LLQRLLDMG 192
Score = 33.9 bits (76), Expect = 0.39
Identities = 26/80 (32%), Positives = 41/80 (51%), Gaps = 5/80 (6%)
Query: 232 GNDAYKKKDFDTALKHYDKAKELDPTNMTYIT---NQAAVYFEKGDYNKCRELCEKAIEV 288
GN+ +K D+ AL Y +A LD T N+AA + + DY+K KAIE
Sbjct: 13 GNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAETEASKAIEK 72
Query: 289 -GRENREDYRQIAKAYARIG 307
G + + YR+ ++A ++G
Sbjct: 73 DGGDVKALYRR-SQALEKLG 91
>gi|29725607 smooth muscle cell associated protein-1 isoform 2 [Homo
sapiens]
Length = 944
Score = 60.8 bits (146), Expect = 3e-09
Identities = 37/122 (30%), Positives = 65/122 (53%), Gaps = 3/122 (2%)
Query: 4 VNELKEKGNKALSVGNIDDALQCYSEAIKLD--PHNH-VLYSNRSAAYAKKGDYQKAYED 60
V +L+++GN+ G+ AL Y++A+ LD P + VL+ NR+A + K DY KA +
Sbjct: 21 VEQLRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAETE 80
Query: 61 GCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLA 120
K ++ K R++ ALE L R ++A + + E N +E L+N+ ++
Sbjct: 81 ASKAIEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQ 140
Query: 121 ER 122
E+
Sbjct: 141 EK 142
Score = 58.9 bits (141), Expect = 1e-08
Identities = 54/189 (28%), Positives = 91/189 (48%), Gaps = 20/189 (10%)
Query: 364 KNKGNECFQKGDYPQAMKHYTEAI--KRNPKD-AKLYSNRAACYTKLLEFQLALKDCEEC 420
+ +GNE F+ GDY A+ YT+A+ P+D A L+ NRAAC+ KL ++ A + +
Sbjct: 25 RKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAETEASKA 84
Query: 421 IQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQRC--MMAQYNR 478
I+ + +K R++ ALE + +A+ Q+ + L+ K + + + + R
Sbjct: 85 IEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEKVR 144
Query: 479 HDSPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKDPQALSEHLKNPVIAQKI------- 531
+ S D K M QI+ DP + E+ QK Q L + A+KI
Sbjct: 145 YMSSTDAKVEQMF-----QILLDPEEK-GTEKKQKASQNLVVLAREDAGAEKIFRSNGVQ 198
Query: 532 --QKLMDVG 538
Q+L+D+G
Sbjct: 199 LLQRLLDMG 207
Score = 35.4 bits (80), Expect = 0.13
Identities = 30/101 (29%), Positives = 50/101 (49%), Gaps = 7/101 (6%)
Query: 211 PEPMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYIT---NQAA 267
PEP + + L+++ GN+ +K D+ AL Y +A LD T N+AA
Sbjct: 9 PEPRPATPGASSVEQLRKE--GNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAA 66
Query: 268 VYFEKGDYNKCRELCEKAIEV-GRENREDYRQIAKAYARIG 307
+ + DY+K KAIE G + + YR+ ++A ++G
Sbjct: 67 CHLKLEDYDKAETEASKAIEKDGGDVKALYRR-SQALEKLG 106
>gi|238859655 tetratricopeptide repeat domain 31 [Homo sapiens]
Length = 519
Score = 60.1 bits (144), Expect = 5e-09
Identities = 42/149 (28%), Positives = 76/149 (51%), Gaps = 10/149 (6%)
Query: 329 EHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNK----GNECFQKGDYPQAMKHYT 384
E +P ++ QQ+ K+ LA AL++ + G Q G Y +A+ +T
Sbjct: 275 EEESPPREERPQQSPKVQASPGLLA-----AALQQSQELAKLGTSFAQNGFYHEAVVLFT 329
Query: 385 EAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDY 444
+A+K NP+D +L+ NR+ C+ +L + AL D + + L P + +G R AL ++ +
Sbjct: 330 QALKLNPQDHRLFGNRSFCHERLGQPAWALADAQVALTLRPGWPRGLFRLGKALMGLQRF 389
Query: 445 TKAMDVYQKALDLDSSCKEAADGYQRCMM 473
+A V+Q+ L S +AA + C++
Sbjct: 390 REAAAVFQETL-RGGSQPDAARELRSCLL 417
Score = 60.1 bits (144), Expect = 5e-09
Identities = 32/100 (32%), Positives = 52/100 (52%)
Query: 1 MEQVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYED 60
++Q EL + G G +A+ +++A+KL+P +H L+ NRS + + G A D
Sbjct: 302 LQQSQELAKLGTSFAQNGFYHEAVVLFTQALKLNPQDHRLFGNRSFCHERLGQPAWALAD 361
Query: 61 GCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLK 100
+ L+P W +G R AL L RF EA ++E L+
Sbjct: 362 AQVALTLRPGWPRGLFRLGKALMGLQRFREAAAVFQETLR 401
>gi|33457330 tetratricopeptide repeat domain 14 isoform a [Homo
sapiens]
Length = 770
Score = 58.5 bits (140), Expect = 1e-08
Identities = 45/149 (30%), Positives = 70/149 (46%), Gaps = 8/149 (5%)
Query: 225 ALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEK 284
ALK ++G D +K A+ Y+KA E+D N+ + + A+Y KG NK E E
Sbjct: 307 ALKCVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFEL 366
Query: 285 AIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEK 344
A+E +R + + + G +EEK+ +A +Y K+LA T + AE
Sbjct: 367 ALENCPTHRNARKYLCQTLVERGGQLEEEEKFLNAESYYKKALALDET------FKDAED 420
Query: 345 ILKEQERLAYINPDLALEEKNKGNECFQK 373
L++ + Y+ L L EK E QK
Sbjct: 421 ALQKLHK--YMQKSLELREKQAEKEEKQK 447
Score = 45.1 bits (105), Expect = 2e-04
Identities = 27/111 (24%), Positives = 53/111 (47%), Gaps = 7/111 (6%)
Query: 367 GNECFQKGDYPQAMKHYTEAIKRNPKDAK-------LYSNRAACYTKLLEFQLALKDCEE 419
G + F+ G + AM Y +A++ + ++ + LY+ + + + +F+LAL++C
Sbjct: 314 GVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPT 373
Query: 420 CIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQR 470
+ + LE + + A Y+KAL LD + K+A D Q+
Sbjct: 374 HRNARKYLCQTLVERGGQLEEEEKFLNAESYYKKALALDETFKDAEDALQK 424
Score = 34.3 bits (77), Expect = 0.30
Identities = 18/44 (40%), Positives = 24/44 (54%)
Query: 17 VGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYED 60
VG DA+ Y++A+++D N R A YA KG KA ED
Sbjct: 320 VGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIED 363
>gi|5453980 DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo
sapiens]
Length = 504
Score = 58.2 bits (139), Expect = 2e-08
Identities = 64/306 (20%), Positives = 130/306 (42%), Gaps = 43/306 (14%)
Query: 188 GSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGN------DAYKKKDF 241
G +DE E+ KK K P E + E + Q +K E+ +A+ D+
Sbjct: 119 GKLDEAEDDF--------KKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDY 170
Query: 242 DTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAK 301
A+ DK E+ + +A + ++G+ K + A ++ +N E + +I+
Sbjct: 171 TAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKIST 230
Query: 302 AYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLAL 361
Y ++G+ + SL+E R + LK Q ++ +++ +N +
Sbjct: 231 LYYQLGD--------------HELSLSEVR--ECLKLDQDHKRCFAHYKQVKKLNKLIES 274
Query: 362 EEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAA-----CYTKLLEFQLALKD 416
E E + G Y A Y +K P A+ Y+ R+ C++K + A++
Sbjct: 275 AE-----ELIRDGRYTDATSKYESVMKTEPSIAE-YTVRSKERICHCFSKDEKPVEAIRV 328
Query: 417 CEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQRC--MMA 474
C E +Q+EP + +A A + Y +A+ Y+ A + + + ++ +G ++ ++
Sbjct: 329 CSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQRLLK 388
Query: 475 QYNRHD 480
Q + D
Sbjct: 389 QSQKRD 394
Score = 52.4 bits (124), Expect = 1e-06
Identities = 78/374 (20%), Positives = 150/374 (40%), Gaps = 48/374 (12%)
Query: 9 EKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLK 68
E G K L+ G + DAL + A+ DP N++ Y R+ + G + A D K + LK
Sbjct: 42 ELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLK 101
Query: 69 PDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEG----LQNMEARLAERKF 124
D+ ++ L + +EA+ +++ LK + + KE +++ E + +
Sbjct: 102 MDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQA 161
Query: 125 MNPFNMPNLYQKLE-SDPRTRTLLSDPTYRELIEQL-------RNKPSDL--GTKLQDPR 174
+N F + + D + D REL + R SDL +KL++
Sbjct: 162 LNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDN 221
Query: 175 I-----MTTLSVLLGVDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEK 229
++TL LG S+ E E K + + + KQ K
Sbjct: 222 TEAFYKISTLYYQLGDHELSLSEVREC------------LKLDQDHKRCFAHYKQVKKLN 269
Query: 230 EL---GNDAYKKKDFDTALKHYDKAKELDPTNMTYIT---NQAAVYFEKGDYN-KCRELC 282
+L + + + A Y+ + +P+ Y + F K + + +C
Sbjct: 270 KLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKDEKPVEAIRVC 329
Query: 283 EKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPD--VLKKCQ 340
+ +++ +N + A+A Y EE Y +AI Y ++ EH D + + +
Sbjct: 330 SEVLQMEPDNVNALKDRAEA-------YLIEEMYDEAIQDY-ETAQEHNENDQQIREGLE 381
Query: 341 QAEKILKEQERLAY 354
+A+++LK+ ++ Y
Sbjct: 382 KAQRLLKQSQKRDY 395
Score = 43.5 bits (101), Expect = 5e-04
Identities = 49/244 (20%), Positives = 92/244 (37%), Gaps = 18/244 (7%)
Query: 227 KEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAI 286
K ELG AL + A + DP N +A V+ G K I
Sbjct: 39 KHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVI 98
Query: 287 EVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKIL 346
++ + A + G+ K+ K +A + K L + + + K+ Q
Sbjct: 99 QLKMD-------FTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKS 151
Query: 347 KEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTK 406
E +RL +++ F GDY A+ + ++ DA+L RA C+ K
Sbjct: 152 DEMQRL-----------RSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIK 200
Query: 407 LLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAAD 466
E + A+ D + +L+ + + + + + D+ ++ ++ L LD K
Sbjct: 201 EGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFA 260
Query: 467 GYQR 470
Y++
Sbjct: 261 HYKQ 264
Score = 41.2 bits (95), Expect = 0.002
Identities = 29/126 (23%), Positives = 58/126 (46%), Gaps = 6/126 (4%)
Query: 1 MEQVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSA-----AYAKKGDYQ 55
++++N+L E + + G DA Y +K +P + Y+ RS ++K
Sbjct: 265 VKKLNKLIESAEELIRDGRYTDATSKYESVMKTEP-SIAEYTVRSKERICHCFSKDEKPV 323
Query: 56 KAYEDGCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNM 115
+A + + ++PD +A A ++EA + YE +H N+ Q++EGL+
Sbjct: 324 EAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKA 383
Query: 116 EARLAE 121
+ L +
Sbjct: 384 QRLLKQ 389
>gi|13899233 tetratricopeptide repeat domain 25 [Homo sapiens]
Length = 672
Score = 58.2 bits (139), Expect = 2e-08
Identities = 42/160 (26%), Positives = 73/160 (45%), Gaps = 8/160 (5%)
Query: 366 KGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEP 425
+G + G++ +A + ++ A+ D R+ C+ K+ + + +LKD E +Q +P
Sbjct: 19 EGERLYLCGEFSKAAQSFSNALYLQDGDKNCLVARSKCFLKMGDLERSLKDAEASLQSDP 78
Query: 426 TFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQRCMMAQYNRHDSPEDV 485
F KG +KA L M D+ A+ Y + L +E G Q+ A N SP +
Sbjct: 79 AFCKGILQKAETLYTMGDFEFALVFYHRGYKLRPD-REFRVGIQKAQEAINNSVGSPSSI 137
Query: 486 KRRAMADPEVQQIMSDPAMRLILEQMQKDPQALSEHLKNP 525
K D +S A + + Q+ PQ + +HL +P
Sbjct: 138 KLENKGD---LSFLSKQAENI---KAQQKPQPM-KHLLHP 170
>gi|22095349 WD and tetratricopeptide repeats 1 [Homo sapiens]
Length = 676
Score = 57.4 bits (137), Expect = 3e-08
Identities = 35/108 (32%), Positives = 57/108 (52%), Gaps = 8/108 (7%)
Query: 350 ERLAYINPDLALEE-----KNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACY 404
E +++P + L K + NE F + QA++ Y++A++R P +A LY NRAA Y
Sbjct: 346 ESRGHVSPQVELPPYLERVKQQANEAFACQQWTQAIQLYSKAVQRAPHNAMLYGNRAAAY 405
Query: 405 TKLL---EFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMD 449
K + AL+DC + I L P +K + R A L +K +A++
Sbjct: 406 MKRKWDGDHYDALRDCLKAISLNPCHLKAHFRLARCLFELKYVAEALE 453
Score = 57.0 bits (136), Expect = 4e-08
Identities = 33/91 (36%), Positives = 49/91 (53%), Gaps = 3/91 (3%)
Query: 4 VNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKK---GDYQKAYED 60
+ +K++ N+A + A+Q YS+A++ PHN +LY NR+AAY K+ GD+ A D
Sbjct: 361 LERVKQQANEAFACQQWTQAIQLYSKAVQRAPHNAMLYGNRAAAYMKRKWDGDHYDALRD 420
Query: 61 GCKTVDLKPDWGKGYSRKAAALEFLNRFEEA 91
K + L P K + R A L L EA
Sbjct: 421 CLKAISLNPCHLKAHFRLARCLFELKYVAEA 451
Score = 32.7 bits (73), Expect = 0.87
Identities = 19/63 (30%), Positives = 32/63 (50%), Gaps = 3/63 (4%)
Query: 229 KELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEK---GDYNKCRELCEKA 285
K+ N+A+ + + A++ Y KA + P N N+AA Y ++ GD+ C KA
Sbjct: 365 KQQANEAFACQQWTQAIQLYSKAVQRAPHNAMLYGNRAAAYMKRKWDGDHYDALRDCLKA 424
Query: 286 IEV 288
I +
Sbjct: 425 ISL 427
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.131 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,273,796
Number of Sequences: 37866
Number of extensions: 1127474
Number of successful extensions: 12227
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 227
Number of HSP's successfully gapped in prelim test: 211
Number of HSP's that attempted gapping in prelim test: 9642
Number of HSP's gapped (non-prelim): 2004
length of query: 543
length of database: 18,247,518
effective HSP length: 107
effective length of query: 436
effective length of database: 14,195,856
effective search space: 6189393216
effective search space used: 6189393216
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.