Guide to the Human Genome
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Search of human proteins with 5729970

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5729970 claudin 16 [Homo sapiens]
         (305 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5729970 claudin 16 [Homo sapiens]                                  638   0.0  
gi|153792186 claudin 7 [Homo sapiens]                                  81   1e-15
gi|10863887 claudin 1 [Homo sapiens]                                   80   2e-15
gi|4502877 claudin 4 [Homo sapiens]                                    72   8e-13
gi|7656981 claudin 15 [Homo sapiens]                                   70   2e-12
gi|10938016 claudin 11 [Homo sapiens]                                  69   5e-12
gi|5921465 claudin 10 isoform b [Homo sapiens]                         65   7e-11
gi|4502875 claudin 3 [Homo sapiens]                                    64   1e-10
gi|47716519 claudin 20 [Homo sapiens]                                  64   2e-10
gi|183979975 claudin 19 isoform b [Homo sapiens]                       62   5e-10
gi|40788011 claudin 8 [Homo sapiens]                                   62   6e-10
gi|11141861 claudin 9 [Homo sapiens]                                   62   8e-10
gi|225703142 claudin 14 [Homo sapiens]                                 61   1e-09
gi|21536294 claudin 14 [Homo sapiens]                                  61   1e-09
gi|225703138 claudin 14 [Homo sapiens]                                 61   1e-09
gi|6912314 claudin 14 [Homo sapiens]                                   61   1e-09
gi|225703140 claudin 14 [Homo sapiens]                                 61   1e-09
gi|169167239 PREDICTED: claudin-24-like [Homo sapiens]                 60   2e-09
gi|169166931 PREDICTED: claudin-24-like [Homo sapiens]                 60   2e-09
gi|7705961 claudin 18 isoform 1 [Homo sapiens]                         60   3e-09
gi|183979973 claudin 19 isoform a [Homo sapiens]                       60   3e-09
gi|153792768 claudin 6 [Homo sapiens]                                  58   9e-09
gi|169166402 PREDICTED: claudin-24-like [Homo sapiens]                 58   1e-08
gi|9966781 claudin 2 [Homo sapiens]                                    57   2e-08
gi|33598916 claudin 10 isoform a [Homo sapiens]                        56   5e-08
gi|50345279 claudin 18 isoform 2 [Homo sapiens]                        55   6e-08
gi|162417973 claudin 22 [Homo sapiens]                                 54   2e-07
gi|231569235 claudin 10 isoform a_i1 [Homo sapiens]                    49   4e-06
gi|6912312 claudin 12 [Homo sapiens]                                   43   4e-04
gi|124107616 claudin 23 [Homo sapiens]                                 37   0.022

>gi|5729970 claudin 16 [Homo sapiens]
          Length = 305

 Score =  638 bits (1645), Expect = 0.0
 Identities = 305/305 (100%), Positives = 305/305 (100%)

Query: 1   MTSRTPLLVTACLYYSYCNSRHLQQGVRKSKRPVFSHCQVPETQKTDTRHLSGARAGVCP 60
           MTSRTPLLVTACLYYSYCNSRHLQQGVRKSKRPVFSHCQVPETQKTDTRHLSGARAGVCP
Sbjct: 1   MTSRTPLLVTACLYYSYCNSRHLQQGVRKSKRPVFSHCQVPETQKTDTRHLSGARAGVCP 60

Query: 61  CCHPDGLLATMRDLLQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKCRGLWWEC 120
           CCHPDGLLATMRDLLQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKCRGLWWEC
Sbjct: 61  CCHPDGLLATMRDLLQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKCRGLWWEC 120

Query: 121 VTNAFDGIRTCDEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEP 180
           VTNAFDGIRTCDEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEP
Sbjct: 121 VTNAFDGIRTCDEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEP 180

Query: 181 YIKVRICFVAGATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGM 240
           YIKVRICFVAGATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGM
Sbjct: 181 YIKVRICFVAGATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGM 240

Query: 241 AGSLGCFLAGAVLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSYSAPRTETAKMYA 300
           AGSLGCFLAGAVLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSYSAPRTETAKMYA
Sbjct: 241 AGSLGCFLAGAVLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSYSAPRTETAKMYA 300

Query: 301 VDTRV 305
           VDTRV
Sbjct: 301 VDTRV 305


>gi|153792186 claudin 7 [Homo sapiens]
          Length = 211

 Score = 80.9 bits (198), Expect = 1e-15
 Identities = 60/228 (26%), Positives = 101/228 (44%), Gaps = 26/228 (11%)

Query: 75  LQYIACFFAFFSAGFLIVATWTDCWMVNA---DDSLEVSTKCRGLWWECVTNAFDGIRTC 131
           LQ +    A      L+  T    W +++   D+ +      +GLW +CVT +  G+ +C
Sbjct: 6   LQLLGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQS-TGMMSC 64

Query: 132 DEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAG 191
             YDS+LA     L  TRALM+ + +L         +G+ C +   D+   K RI    G
Sbjct: 65  KMYDSVLALSAA-LQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAMGGG 123

Query: 192 ATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGA 251
              ++AG   ++   WY   +  +    ++      I+Y+FG + ++G AGS    L GA
Sbjct: 124 IIFIVAGLAALVACSWYGHQIVTDFYNPLIPT---NIKYEFGPAIFIGWAGSALVILGGA 180

Query: 252 VLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSYSAPRTETAKMY 299
           +L+C                S     S AG  + +SY  P++ ++K Y
Sbjct: 181 LLSC----------------SCPGNESKAGYRVPRSY--PKSNSSKEY 210


>gi|10863887 claudin 1 [Homo sapiens]
          Length = 211

 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 61/221 (27%), Positives = 96/221 (43%), Gaps = 24/221 (10%)

Query: 74  LLQYIACFFAFFSAGFLIVATWTDCWMVNA---DDSLEVSTKCRGLWWECVTNAFDGIRT 130
           LL +I  F  +  A   IV+T    W + +   D+ +       GLW  CV+ +   I+ 
Sbjct: 8   LLGFILAFLGWIGA---IVSTALPQWRIYSYAGDNIVTAQAMYEGLWMSCVSQSTGQIQ- 63

Query: 131 CDEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVA 190
           C  +DS+L      L  TRALM+   +L         +G+ C+K L D+   K+R+  + 
Sbjct: 64  CKVFDSLL-NLSSTLQATRALMVVGILLGVIAIFVATVGMKCMKCLEDDEVQKMRMAVIG 122

Query: 191 GATLLIAGTPGIIGSVWYA---VDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCF 247
           GA  L+AG   ++ + WY    V  + +  T V        +Y+FG + + G A +  C 
Sbjct: 123 GAIFLLAGLAILVATAWYGNRIVQEFYDPMTPV------NARYEFGQALFTGWAAASLCL 176

Query: 248 LAGAVLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSY 288
           L GA+L C         P +   Y   + Y     S  K Y
Sbjct: 177 LGGALLCCSC-------PRKTTSYPTPRPYPKPAPSSGKDY 210


>gi|4502877 claudin 4 [Homo sapiens]
          Length = 209

 Score = 71.6 bits (174), Expect = 8e-13
 Identities = 63/193 (32%), Positives = 90/193 (46%), Gaps = 17/193 (8%)

Query: 99  WMVNA---DDSLEVSTKCRGLWWECVTNAFDGIRTCDEYDSILAEHPLKLVVTRALMITA 155
           W V A    + +   T   GLW  CV  +  G   C  YDS+LA  P  L   RAL+I +
Sbjct: 30  WRVTAFIGSNIVTSQTIWEGLWMNCVVQS-TGQMQCKVYDSLLAL-PQDLQAARALVIIS 87

Query: 156 DILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAGATLLIAGTPGIIGSVWYAVDVYVE 215
            I+A  G L  ++G  C   L DE   K +   VAG   L+AG   I+   W A ++  +
Sbjct: 88  IIVAALGVLLSVVGGKCTNCLEDES-AKAKTMIVAGVVFLLAGLMVIVPVSWTAHNIIQD 146

Query: 216 RSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGAVLTCCLYLFKDVGPERNYPYSLRK 275
               ++ +   G + + G S ++G A S G  L G  L CC     +  P  + PYS + 
Sbjct: 147 FYNPLVAS---GQKREMGASLYVGWAAS-GLLLLGGGLLCC-----NCPPRTDKPYSAK- 196

Query: 276 AYSAAGVSMAKSY 288
            YSAA  + A +Y
Sbjct: 197 -YSAARSAAASNY 208


>gi|7656981 claudin 15 [Homo sapiens]
          Length = 228

 Score = 70.1 bits (170), Expect = 2e-12
 Identities = 58/198 (29%), Positives = 90/198 (45%), Gaps = 14/198 (7%)

Query: 82  FAFFSA--GFLIVATW--TDCWMVNA--DDSLEVSTKCRGLWWECVTNAFDGIRTCDEYD 135
           F FF A  G L++        W V+    + +  +T    LW+ C T++  G+  C E+ 
Sbjct: 8   FGFFMATVGLLMLGVTLPNSYWRVSTVHGNVITTNTIFENLWFSCATDSL-GVYNCWEFP 66

Query: 136 SILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAGATLL 195
           S+LA     +   RALMITA +L   G L  + GL C      E   K ++   AGA  +
Sbjct: 67  SMLALSGY-IQACRALMITAILLGFLGLLLGIAGLRCTNIGGLELSRKAKLAATAGALHI 125

Query: 196 IAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGAVL-- 253
           +AG  G++   WYA ++  +        ++ G +Y+ G + +LG + SL   L G  L  
Sbjct: 126 LAGICGMVAISWYAFNITRD----FFDPLYPGTKYELGPALYLGWSASLISILGGLCLCS 181

Query: 254 TCCLYLFKDVGPERNYPY 271
            CC    +D       PY
Sbjct: 182 ACCCGSDEDPAASARRPY 199


>gi|10938016 claudin 11 [Homo sapiens]
          Length = 207

 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 55/208 (26%), Positives = 93/208 (44%), Gaps = 22/208 (10%)

Query: 67  LLATMRDLLQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKC-----RGLWWECV 121
           ++AT   ++ ++  F  +     +IV T T+ W+V    ++    K      +GLW +CV
Sbjct: 1   MVATCLQVVGFVTSFVGWIG---VIVTTSTNDWVVTCGYTIPTCRKLDELGSKGLWADCV 57

Query: 122 TNAFDGIRTCDEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPY 181
                G+  C     IL   P  +   RALMI A +L     L LL  L C++   +   
Sbjct: 58  MAT--GLYHCKPLVDILIL-PGYVQACRALMIAASVLGLPAILLLLTVLPCIRMGQEPGV 114

Query: 182 IKVRICFVAGATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMA 241
            K R   +AG  L++     ++ ++W+ V  + E +T+V           FG+S + G  
Sbjct: 115 AKYRRAQLAGVLLILLALCALVATIWFPVCAHRE-TTIV----------SFGYSLYAGWI 163

Query: 242 GSLGCFLAGAVLTCCLYLFKDVGPERNY 269
           G++ C + G V+ CC    +  G  R Y
Sbjct: 164 GAVLCLVGGCVILCCAGDAQAFGENRFY 191


>gi|5921465 claudin 10 isoform b [Homo sapiens]
          Length = 228

 Score = 65.1 bits (157), Expect = 7e-11
 Identities = 50/178 (28%), Positives = 83/178 (46%), Gaps = 10/178 (5%)

Query: 78  IACFFAFFSAGFLIVATW-TDCWMVNADDSLEVSTKC--RGLWWECVTNAFDGIRTCDEY 134
           I  F    S   L+ +T  TD W V+  D   ++T      LW  CVT++  G+  C ++
Sbjct: 8   IIAFMVSISGWVLVSSTLPTDYWKVSTIDGTVITTATYWANLWKACVTDS-TGVSNCKDF 66

Query: 135 DSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAGATL 194
            S+LA     +   R LMI A  L  FG +  L G+ C K +      K +I  +AG   
Sbjct: 67  PSMLALDGY-IQACRGLMIAAVSLGFFGSIFALFGMKCTK-VGGSDKAKAKIACLAGIVF 124

Query: 195 LIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGAV 252
           +++G   + G   YA  +    +T     +F+  +Y+ G + ++G AG+  C + G +
Sbjct: 125 ILSGLCSMTGCSLYANKI----TTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVI 178


>gi|4502875 claudin 3 [Homo sapiens]
          Length = 220

 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 60/206 (29%), Positives = 85/206 (41%), Gaps = 26/206 (12%)

Query: 91  IVATWTDCWMVNADDSLEVSTK---CRGLWWECVTNAFDGIRTCDEYDSILAEHPLKLVV 147
           IV      W V+A     + T      GLW  CV  +  G   C  YDS+LA  P  L  
Sbjct: 21  IVCCALPMWRVSAFIGSNIITSQNIWEGLWMNCVVQS-TGQMQCKVYDSLLAL-PQDLQA 78

Query: 148 TRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAGATLLIAGTPGIIGSVW 207
            RAL++ A +LA FG L  L+G  C   + D+   K +I  VAG   L+A    ++   W
Sbjct: 79  ARALIVVAILLAAFGLLVALVGAQCTNCVQDDT-AKAKITIVAGVLFLLAALLTLVPVSW 137

Query: 208 YAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGAVLTCCLYLFKDVGPER 267
            A  +  +    V+       + + G   ++G A +    L GA+L C         P R
Sbjct: 138 SANTIIRDFYNPVVPE---AQKREMGAGLYVGWAAAALQLLGGALLCCSC-------PPR 187

Query: 268 NYPYSLRKAYSAAGVSMAKSYSAPRT 293
              Y+  K            YSAPR+
Sbjct: 188 EKKYTATKVV----------YSAPRS 203


>gi|47716519 claudin 20 [Homo sapiens]
          Length = 219

 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 48/187 (25%), Positives = 84/187 (44%), Gaps = 10/187 (5%)

Query: 75  LQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVST---KCRGLWWECVTNAFDGIRTC 131
           LQ +A   A      ++ AT    W VN D    + T   +  GLW +C T    G+ +C
Sbjct: 6   LQLLAFILALSGVSGVLTATLLPNWKVNVDVDSNIITAIVQLHGLWMDC-TWYSTGMFSC 64

Query: 132 DEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAG 191
               SIL+  P+ +   RA M+ A +L+  G  T  +G+ C + L  +   K    F  G
Sbjct: 65  ALKHSILS-LPIHVQAARATMVLACVLSALGICTSTVGMKCTR-LGGDRETKSHASFAGG 122

Query: 192 ATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGA 251
              + AG   +I +VWY  ++      L +       +++ G + ++G   ++  F++G 
Sbjct: 123 VCFMSAGISSLISTVWYTKEIIANFLDLTVPE---SNKHEPGGAIYIGFISAMLLFISGM 179

Query: 252 VL-TCCL 257
           +  T C+
Sbjct: 180 IFCTSCI 186


>gi|183979975 claudin 19 isoform b [Homo sapiens]
          Length = 211

 Score = 62.4 bits (150), Expect = 5e-10
 Identities = 57/222 (25%), Positives = 90/222 (40%), Gaps = 25/222 (11%)

Query: 75  LQYIACFFAFFSAGFLIVATWTDCWMVNA---DDSLEVSTKCRGLWWECVTNAFDGIRTC 131
           LQ +  F A      +I +T    W  ++   D  +       GLW  C + +   ++ C
Sbjct: 6   LQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQ-C 64

Query: 132 DEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAG 191
             YDS+LA     +   RALM+ A +L     +  ++G+ C +     P  K R+    G
Sbjct: 65  KLYDSLLALDG-HIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAIAGG 123

Query: 192 ATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIF-----LGIQYKFGWSCWLGMAGSLGC 246
           A  ++AG   +    WYA        TLV    F     +  +Y+FG + ++G A S G 
Sbjct: 124 ALFILAGLCTLTAVSWYA--------TLVTQEFFNPSTPVNARYEFGPALFVGWA-SAGL 174

Query: 247 FLAGAVLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSY 288
            + G    CC        PE   P S  + Y     + A+ Y
Sbjct: 175 AVLGGSFLCC------TCPEPERPNSSPQPYRPGPSAAAREY 210


>gi|40788011 claudin 8 [Homo sapiens]
          Length = 225

 Score = 62.0 bits (149), Expect = 6e-10
 Identities = 47/162 (29%), Positives = 72/162 (44%), Gaps = 14/162 (8%)

Query: 115 GLWWECVTNAFDGIRT-CDEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCV 173
           GLW  CV  A   IR  C  YDS+LA  P  L   R LM  A +++   F+  +LG+ C 
Sbjct: 49  GLWMNCVRQA--NIRMQCKIYDSLLALSP-DLQAARGLMCAASVMSFLAFMMAILGMKCT 105

Query: 174 KFLPDEPYIKVRICFVAGATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYK-- 231
           +   D   +K  I   AG   +I G   +I   W A  +  +      +N  + +  K  
Sbjct: 106 RCTGDNEKVKAHILLTAGIIFIITGMVVLIPVSWVANAIIRD-----FYNSIVNVAQKRE 160

Query: 232 FGWSCWLGMAGSLGCFLAGAVLTCCLYLFKDVGPERNYPYSL 273
            G + +LG   +L   + G  L CC++   +     +Y YS+
Sbjct: 161 LGEALYLGWTTAL-VLIVGGALFCCVFCCNE--KSSSYRYSI 199


>gi|11141861 claudin 9 [Homo sapiens]
          Length = 217

 Score = 61.6 bits (148), Expect = 8e-10
 Identities = 49/142 (34%), Positives = 66/142 (46%), Gaps = 8/142 (5%)

Query: 115 GLWWECVTNAFDGIRTCDEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVK 174
           GLW  CV  +  G   C  YDS+LA  P  L   RAL + A +LA  G L  + G  C  
Sbjct: 49  GLWMSCVVQS-TGQMQCKVYDSLLAL-PQDLQAARALCVIALLLALLGLLVAITGAQCTT 106

Query: 175 FLPDEPYIKVRICFVAGATLLIAGTPGIIGSVWYAVDVYVE-RSTLVLHNIFLGIQYKFG 233
            + DE   K RI   AG  LL+AG   +I   W A  +  +  + LV       ++ + G
Sbjct: 107 CVEDEG-AKARIVLTAGVILLLAGILVLIPVCWTAHAIIQDFYNPLVAE----ALKRELG 161

Query: 234 WSCWLGMAGSLGCFLAGAVLTC 255
            S +LG A +    L G +L C
Sbjct: 162 ASLYLGWAAAALLMLGGGLLCC 183


>gi|225703142 claudin 14 [Homo sapiens]
          Length = 239

 Score = 60.8 bits (146), Expect = 1e-09
 Identities = 55/220 (25%), Positives = 92/220 (41%), Gaps = 14/220 (6%)

Query: 75  LQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKC---RGLWWECVTNAFDGIRTC 131
           +Q +    +F      ++ T    W   A     + T     +GLW ECV ++  GI  C
Sbjct: 6   VQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHS-TGIYQC 64

Query: 132 DEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAG 191
             Y S+LA  P  L   RALM+ + +L+G      ++G+ C +     P  K     + G
Sbjct: 65  QIYRSLLAL-PQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTP-AKTTFAILGG 122

Query: 192 ATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGA 251
              ++AG   ++   W   DV       +L +   G++++ G + +LG   S    + G 
Sbjct: 123 TLFILAGLLCMVAVSWTTNDVVQNFYNPLLPS---GMKFEIGQALYLGFISSSLSLIGGT 179

Query: 252 VLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSYSAP 291
           +L  CL   +D  P R  PY      +    + A +Y  P
Sbjct: 180 LL--CLSC-QDEAPYR--PYQAPPRATTTTANTAPAYQPP 214


>gi|21536294 claudin 14 [Homo sapiens]
          Length = 239

 Score = 60.8 bits (146), Expect = 1e-09
 Identities = 55/220 (25%), Positives = 92/220 (41%), Gaps = 14/220 (6%)

Query: 75  LQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKC---RGLWWECVTNAFDGIRTC 131
           +Q +    +F      ++ T    W   A     + T     +GLW ECV ++  GI  C
Sbjct: 6   VQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHS-TGIYQC 64

Query: 132 DEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAG 191
             Y S+LA  P  L   RALM+ + +L+G      ++G+ C +     P  K     + G
Sbjct: 65  QIYRSLLAL-PQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTP-AKTTFAILGG 122

Query: 192 ATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGA 251
              ++AG   ++   W   DV       +L +   G++++ G + +LG   S    + G 
Sbjct: 123 TLFILAGLLCMVAVSWTTNDVVQNFYNPLLPS---GMKFEIGQALYLGFISSSLSLIGGT 179

Query: 252 VLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSYSAP 291
           +L  CL   +D  P R  PY      +    + A +Y  P
Sbjct: 180 LL--CLSC-QDEAPYR--PYQAPPRATTTTANTAPAYQPP 214


>gi|225703138 claudin 14 [Homo sapiens]
          Length = 239

 Score = 60.8 bits (146), Expect = 1e-09
 Identities = 55/220 (25%), Positives = 92/220 (41%), Gaps = 14/220 (6%)

Query: 75  LQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKC---RGLWWECVTNAFDGIRTC 131
           +Q +    +F      ++ T    W   A     + T     +GLW ECV ++  GI  C
Sbjct: 6   VQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHS-TGIYQC 64

Query: 132 DEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAG 191
             Y S+LA  P  L   RALM+ + +L+G      ++G+ C +     P  K     + G
Sbjct: 65  QIYRSLLAL-PQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTP-AKTTFAILGG 122

Query: 192 ATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGA 251
              ++AG   ++   W   DV       +L +   G++++ G + +LG   S    + G 
Sbjct: 123 TLFILAGLLCMVAVSWTTNDVVQNFYNPLLPS---GMKFEIGQALYLGFISSSLSLIGGT 179

Query: 252 VLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSYSAP 291
           +L  CL   +D  P R  PY      +    + A +Y  P
Sbjct: 180 LL--CLSC-QDEAPYR--PYQAPPRATTTTANTAPAYQPP 214


>gi|6912314 claudin 14 [Homo sapiens]
          Length = 239

 Score = 60.8 bits (146), Expect = 1e-09
 Identities = 55/220 (25%), Positives = 92/220 (41%), Gaps = 14/220 (6%)

Query: 75  LQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKC---RGLWWECVTNAFDGIRTC 131
           +Q +    +F      ++ T    W   A     + T     +GLW ECV ++  GI  C
Sbjct: 6   VQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHS-TGIYQC 64

Query: 132 DEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAG 191
             Y S+LA  P  L   RALM+ + +L+G      ++G+ C +     P  K     + G
Sbjct: 65  QIYRSLLAL-PQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTP-AKTTFAILGG 122

Query: 192 ATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGA 251
              ++AG   ++   W   DV       +L +   G++++ G + +LG   S    + G 
Sbjct: 123 TLFILAGLLCMVAVSWTTNDVVQNFYNPLLPS---GMKFEIGQALYLGFISSSLSLIGGT 179

Query: 252 VLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSYSAP 291
           +L  CL   +D  P R  PY      +    + A +Y  P
Sbjct: 180 LL--CLSC-QDEAPYR--PYQAPPRATTTTANTAPAYQPP 214


>gi|225703140 claudin 14 [Homo sapiens]
          Length = 239

 Score = 60.8 bits (146), Expect = 1e-09
 Identities = 55/220 (25%), Positives = 92/220 (41%), Gaps = 14/220 (6%)

Query: 75  LQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKC---RGLWWECVTNAFDGIRTC 131
           +Q +    +F      ++ T    W   A     + T     +GLW ECV ++  GI  C
Sbjct: 6   VQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHS-TGIYQC 64

Query: 132 DEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAG 191
             Y S+LA  P  L   RALM+ + +L+G      ++G+ C +     P  K     + G
Sbjct: 65  QIYRSLLAL-PQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTP-AKTTFAILGG 122

Query: 192 ATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGA 251
              ++AG   ++   W   DV       +L +   G++++ G + +LG   S    + G 
Sbjct: 123 TLFILAGLLCMVAVSWTTNDVVQNFYNPLLPS---GMKFEIGQALYLGFISSSLSLIGGT 179

Query: 252 VLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSYSAP 291
           +L  CL   +D  P R  PY      +    + A +Y  P
Sbjct: 180 LL--CLSC-QDEAPYR--PYQAPPRATTTTANTAPAYQPP 214


>gi|169167239 PREDICTED: claudin-24-like [Homo sapiens]
          Length = 220

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 48/184 (26%), Positives = 79/184 (42%), Gaps = 4/184 (2%)

Query: 72  RDLLQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKCRGLWWECVTNAFDGIRTC 131
           R  +Q +    +F      I+ T+   W     D  E+     GLW  CV     G++ C
Sbjct: 6   RTAMQSVGLLLSFLGWILSIITTYLPHWKNLNLDLNEMENWTMGLWQTCVIQEEVGMQ-C 64

Query: 132 DEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAG 191
            ++DS LA  P +L V+R LM  ++ L   G L    GLDC++    +  +K R+  + G
Sbjct: 65  KDFDSFLAL-PAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGG 123

Query: 192 ATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGA 251
                +G   ++   W A     E     + +     +++FG + +LG    L   L G 
Sbjct: 124 ILSWASGITALVPVSWVAHKTVQEFWDENVPDFV--PRWEFGEALFLGWFAGLSLLLGGC 181

Query: 252 VLTC 255
           +L C
Sbjct: 182 LLNC 185


>gi|169166931 PREDICTED: claudin-24-like [Homo sapiens]
          Length = 220

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 48/184 (26%), Positives = 79/184 (42%), Gaps = 4/184 (2%)

Query: 72  RDLLQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKCRGLWWECVTNAFDGIRTC 131
           R  +Q +    +F      I+ T+   W     D  E+     GLW  CV     G++ C
Sbjct: 6   RTAMQSVGLLLSFLGWILSIITTYLPHWKNLNLDLNEMENWTMGLWQTCVIQEEVGMQ-C 64

Query: 132 DEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAG 191
            ++DS LA  P +L V+R LM  ++ L   G L    GLDC++    +  +K R+  + G
Sbjct: 65  KDFDSFLAL-PAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGG 123

Query: 192 ATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGA 251
                +G   ++   W A     E     + +     +++FG + +LG    L   L G 
Sbjct: 124 ILSWASGITALVPVSWVAHKTVQEFWDENVPDFV--PRWEFGEALFLGWFAGLSLLLGGC 181

Query: 252 VLTC 255
           +L C
Sbjct: 182 LLNC 185


>gi|7705961 claudin 18 isoform 1 [Homo sapiens]
          Length = 261

 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 58/222 (26%), Positives = 91/222 (40%), Gaps = 21/222 (9%)

Query: 76  QYIACFFAFFSAGFLIVATWTDCWMVNA--DDSLEVSTKCRGLWWECVTNAFDGIRTCDE 133
           Q +A   +       I AT  D W      D+ +    +  GLW  CV  +  G   C  
Sbjct: 7   QVVAFLLSILGLAGCIAATGMDMWSTQDLYDNPVTSVFQYEGLWRSCVRQS-SGFTECRP 65

Query: 134 YDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAGAT 193
           Y +IL   P  L   RALMI   +L   G L  +  L C++    E   K  +   +G  
Sbjct: 66  YFTILGL-PAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIM 124

Query: 194 LLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGI---------QYKFGWSCWLGMAGSL 244
            +++G   I G   +A ++ V    +   N++ G+         +Y FG + ++G     
Sbjct: 125 FIVSGLCAIAGVSVFA-NMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAG- 182

Query: 245 GCFLAGAVLTCCLYLFKDVGPER-NYPYSLRKAYSAAGVSMA 285
           G  L G V+ C     + + PE  NY      +Y A+G S+A
Sbjct: 183 GLTLIGGVMMC--IACRGLAPEETNYK---AVSYHASGHSVA 219


>gi|183979973 claudin 19 isoform a [Homo sapiens]
          Length = 224

 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 50/190 (26%), Positives = 80/190 (42%), Gaps = 19/190 (10%)

Query: 75  LQYIACFFAFFSAGFLIVATWTDCWMVNA---DDSLEVSTKCRGLWWECVTNAFDGIRTC 131
           LQ +  F A      +I +T    W  ++   D  +       GLW  C + +   ++ C
Sbjct: 6   LQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQ-C 64

Query: 132 DEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAG 191
             YDS+LA     +   RALM+ A +L     +  ++G+ C +     P  K R+    G
Sbjct: 65  KLYDSLLALDG-HIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAIAGG 123

Query: 192 ATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIF-----LGIQYKFGWSCWLGMAGSLGC 246
           A  ++AG   +    WYA        TLV    F     +  +Y+FG + ++G A S G 
Sbjct: 124 ALFILAGLCTLTAVSWYA--------TLVTQEFFNPSTPVNARYEFGPALFVGWA-SAGL 174

Query: 247 FLAGAVLTCC 256
            + G    CC
Sbjct: 175 AVLGGSFLCC 184


>gi|153792768 claudin 6 [Homo sapiens]
          Length = 220

 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 55/175 (31%), Positives = 75/175 (42%), Gaps = 13/175 (7%)

Query: 115 GLWWECVTNAFDGIRTCDEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVK 174
           GLW  CV  +  G   C  YDS+LA  P  L   RAL + A ++A FG L  L G  C  
Sbjct: 49  GLWMSCVVQS-TGQMQCKVYDSLLAL-PQDLQAARALCVIALLVALFGLLVYLAGAKCTT 106

Query: 175 FLPDEPYIKVRICFVAGATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYK--F 232
            + +E   K R+   +G   +I+G   +I   W A  +  +      +N  +    K   
Sbjct: 107 CV-EEKDSKARLVLTSGIVFVISGVLTLIPVCWTAHAIIRD-----FYNPLVAEAQKREL 160

Query: 233 GWSCWLGMAGSLGCFLAGAVLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKS 287
           G S +LG A S G  L G  L CC       G +    Y  R + SA  +S   S
Sbjct: 161 GASLYLGWAAS-GLLLLGGGLLCC--TCPSGGSQGPSHYMARYSTSAPAISRGPS 212


>gi|169166402 PREDICTED: claudin-24-like [Homo sapiens]
          Length = 220

 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 47/184 (25%), Positives = 78/184 (42%), Gaps = 4/184 (2%)

Query: 72  RDLLQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKCRGLWWECVTNAFDGIRTC 131
           R  +Q +    +       I+ T+   W     D  E+     GLW  CV     G++ C
Sbjct: 6   RTAMQSVGLLLSLLGWILSIITTYLPHWKNLNLDLNEMENWTMGLWQTCVIQEEVGMQ-C 64

Query: 132 DEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAG 191
            ++DS LA  P +L V+R LM  ++ L   G L    GLDC++    +  +K R+  + G
Sbjct: 65  KDFDSFLAL-PAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGG 123

Query: 192 ATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGA 251
                +G   ++   W A     E     + +     +++FG + +LG    L   L G 
Sbjct: 124 ILSWASGITALVPVSWVAHKTVQEFWDENVPDFV--PRWEFGEALFLGWFAGLSLLLGGC 181

Query: 252 VLTC 255
           +L C
Sbjct: 182 LLNC 185


>gi|9966781 claudin 2 [Homo sapiens]
          Length = 230

 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 35/140 (25%), Positives = 69/140 (49%), Gaps = 6/140 (4%)

Query: 114 RGLWWECVTNAFDGIRTCDEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCV 173
           +GLW EC T++  GI  CD Y ++L   P  +   +A+M+T+  ++    +  ++G+ C 
Sbjct: 48  KGLWMECATHS-TGITQCDIYSTLLG-LPADIQAAQAMMVTSSAISSLACIISVVGMRCT 105

Query: 174 KFLPDEPYIKVRICFVAGATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFG 233
            F   E   K R+    G   ++ G  G I   W    +  +  + ++ +    ++++ G
Sbjct: 106 VFC-QESRAKDRVAVAGGVFFILGGLLGFIPVAWNLHGILRDFYSPLVPD---SMKFEIG 161

Query: 234 WSCWLGMAGSLGCFLAGAVL 253
            + +LG+  SL   +AG +L
Sbjct: 162 EALYLGIISSLFSLIAGIIL 181


>gi|33598916 claudin 10 isoform a [Homo sapiens]
          Length = 226

 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 44/167 (26%), Positives = 74/167 (44%), Gaps = 9/167 (5%)

Query: 88  GFLIVATWTDCWMVN--ADDSLEVSTKCRGLWWECVTNAFDGIRTCDEYDSILAEHPLKL 145
           G L+ AT ++ W V   A   +  +   +GLW  C  NA      C  + +I       +
Sbjct: 17  GALVAATTSNEWKVTTRASSVITATWVYQGLWMNCAGNALGSFH-CRPHFTIFKVAGY-I 74

Query: 146 VVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAGATLLIAGTPGIIGS 205
              R LMI A  L  FG +  L G+ C K +      K +I  +AG   +++G   + G 
Sbjct: 75  QACRGLMIAAVSLGFFGSIFALFGMKCTK-VGGSDKAKAKIACLAGIVFILSGLCSMTGC 133

Query: 206 VWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGAV 252
             YA  +    +T     +F+  +Y+ G + ++G AG+  C + G +
Sbjct: 134 SLYANKI----TTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVI 176


>gi|50345279 claudin 18 isoform 2 [Homo sapiens]
          Length = 261

 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 54/208 (25%), Positives = 88/208 (42%), Gaps = 21/208 (10%)

Query: 90  LIVATWTDCWMVNA--DDSLEVSTKCRGLWWECVTNAFDGIRTCDEYDSILAEHPLKLVV 147
           +I AT  D W      ++ +      +GLW  CV  +  G   C  Y ++L   P  L  
Sbjct: 21  IIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRES-SGFTECRGYFTLLGL-PAMLQA 78

Query: 148 TRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAGATLLIAGTPGIIGSVW 207
            RALMI   +L   G L  +  L C++    E   K  +   +G   +++G   I G   
Sbjct: 79  VRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSV 138

Query: 208 YAVDVYVERSTLVLHNIFLGI---------QYKFGWSCWLGMAGSLGCFLAGAVLTCCLY 258
           +A ++ V    +   N++ G+         +Y FG + ++G     G  L G V+ C   
Sbjct: 139 FA-NMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAG-GLTLIGGVMMC--I 194

Query: 259 LFKDVGPER-NYPYSLRKAYSAAGVSMA 285
             + + PE  NY      +Y A+G S+A
Sbjct: 195 ACRGLAPEETNYK---AVSYHASGHSVA 219


>gi|162417973 claudin 22 [Homo sapiens]
          Length = 220

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 42/151 (27%), Positives = 68/151 (45%), Gaps = 4/151 (2%)

Query: 105 DSLEVSTKCRGLWWECVTNAFDGIRTCDEYDSILAEHPLKLVVTRALMITADILAGFGFL 164
           D  E+     GLW  CV     G++ C ++DS LA  P +L V+R LM  ++ L   G L
Sbjct: 39  DLNEMENWTMGLWQTCVIQEEVGMQ-CKDFDSFLAL-PAELRVSRILMFLSNGLGFLGLL 96

Query: 165 TLLLGLDCVKFLPDEPYIKVRICFVAGATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNI 224
               GLDC++    +  +K R+  + G     +G   ++   W A     E     + + 
Sbjct: 97  VSGFGLDCLRIGESQRDLKRRLLILGGILSWASGVTALVPVSWVAHKTVQEFWDENVPDF 156

Query: 225 FLGIQYKFGWSCWLGMAGSLGCFLAGAVLTC 255
               +++FG + +LG    L   L G +L C
Sbjct: 157 V--PRWEFGEALFLGWFAGLSLLLGGCLLHC 185


>gi|231569235 claudin 10 isoform a_i1 [Homo sapiens]
          Length = 207

 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 42/167 (25%), Positives = 70/167 (41%), Gaps = 28/167 (16%)

Query: 88  GFLIVATWTDCWMVN--ADDSLEVSTKCRGLWWECVTNAFDGIRTCDEYDSILAEHPLKL 145
           G L+ AT ++ W V   A   +  +   +GLW  C       I+ C              
Sbjct: 17  GALVAATTSNEWKVTTRASSVITATWVYQGLWMNCAGY----IQAC-------------- 58

Query: 146 VVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAGATLLIAGTPGIIGS 205
              R LMI A  L  FG +  L G+ C K +      K +I  +AG   +++G   + G 
Sbjct: 59  ---RGLMIAAVSLGFFGSIFALFGMKCTK-VGGSDKAKAKIACLAGIVFILSGLCSMTGC 114

Query: 206 VWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGAV 252
             YA  +    +T     +F+  +Y+ G + ++G AG+  C + G +
Sbjct: 115 SLYANKI----TTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVI 157


>gi|6912312 claudin 12 [Homo sapiens]
          Length = 244

 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 46/199 (23%), Positives = 82/199 (41%), Gaps = 29/199 (14%)

Query: 69  ATMRDLLQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKCRGLWWECVTNAFDGI 128
           AT+   L  IA     F+   L    W    ++  + + +  T   GLW +C    +DG 
Sbjct: 9   ATVLSFLCGIASVAGLFAGTLL--PNWRKLRLITFNRNEKNLTVYTGLWVKCAR--YDGS 64

Query: 129 RTCDEYDSIL--AEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRI 186
             C  YD+    +   L L V +  +  + ++A    L  L+G+    F    P IK+  
Sbjct: 65  SDCLMYDTTWYSSVDQLDLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIKLAK 124

Query: 187 CFV--------AGATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYK----FGW 234
           C V        AG    +AGT  +  S+W           ++ +NI L  +++    F +
Sbjct: 125 CLVNSAGCHLVAGLLFFLAGTVSLSPSIW-----------VIFYNIHLNKKFEPVFSFDY 173

Query: 235 SCWLGMAGSLGCFLAGAVL 253
           + ++ +A + G F+   +L
Sbjct: 174 AVYVTIASAGGLFMTSLIL 192


>gi|124107616 claudin 23 [Homo sapiens]
          Length = 292

 Score = 37.0 bits (84), Expect = 0.022
 Identities = 29/95 (30%), Positives = 43/95 (45%), Gaps = 6/95 (6%)

Query: 114 RGLWWECVTNAFDGIRTCDEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCV 173
           +GLW  C   +    R C + D         ++V RALM+T+      G L   LG+ C 
Sbjct: 47  QGLWDMCREQS-SRERECGQTDQWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCW 105

Query: 174 KFLPDEPYIKVRICFVAGATLLIAGTPGIIGSVWY 208
           +   DEP     +  ++G  L +AG  G+I   WY
Sbjct: 106 Q---DEP--NFVLAGLSGVVLFVAGLLGLIPVSWY 135


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.327    0.140    0.462 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,169,424
Number of Sequences: 37866
Number of extensions: 464448
Number of successful extensions: 1139
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 1097
Number of HSP's gapped (non-prelim): 37
length of query: 305
length of database: 18,247,518
effective HSP length: 102
effective length of query: 203
effective length of database: 14,385,186
effective search space: 2920192758
effective search space used: 2920192758
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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