BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|5729970 claudin 16 [Homo sapiens] (305 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|5729970 claudin 16 [Homo sapiens] 638 0.0 gi|153792186 claudin 7 [Homo sapiens] 81 1e-15 gi|10863887 claudin 1 [Homo sapiens] 80 2e-15 gi|4502877 claudin 4 [Homo sapiens] 72 8e-13 gi|7656981 claudin 15 [Homo sapiens] 70 2e-12 gi|10938016 claudin 11 [Homo sapiens] 69 5e-12 gi|5921465 claudin 10 isoform b [Homo sapiens] 65 7e-11 gi|4502875 claudin 3 [Homo sapiens] 64 1e-10 gi|47716519 claudin 20 [Homo sapiens] 64 2e-10 gi|183979975 claudin 19 isoform b [Homo sapiens] 62 5e-10 gi|40788011 claudin 8 [Homo sapiens] 62 6e-10 gi|11141861 claudin 9 [Homo sapiens] 62 8e-10 gi|225703142 claudin 14 [Homo sapiens] 61 1e-09 gi|21536294 claudin 14 [Homo sapiens] 61 1e-09 gi|225703138 claudin 14 [Homo sapiens] 61 1e-09 gi|6912314 claudin 14 [Homo sapiens] 61 1e-09 gi|225703140 claudin 14 [Homo sapiens] 61 1e-09 gi|169167239 PREDICTED: claudin-24-like [Homo sapiens] 60 2e-09 gi|169166931 PREDICTED: claudin-24-like [Homo sapiens] 60 2e-09 gi|7705961 claudin 18 isoform 1 [Homo sapiens] 60 3e-09 gi|183979973 claudin 19 isoform a [Homo sapiens] 60 3e-09 gi|153792768 claudin 6 [Homo sapiens] 58 9e-09 gi|169166402 PREDICTED: claudin-24-like [Homo sapiens] 58 1e-08 gi|9966781 claudin 2 [Homo sapiens] 57 2e-08 gi|33598916 claudin 10 isoform a [Homo sapiens] 56 5e-08 gi|50345279 claudin 18 isoform 2 [Homo sapiens] 55 6e-08 gi|162417973 claudin 22 [Homo sapiens] 54 2e-07 gi|231569235 claudin 10 isoform a_i1 [Homo sapiens] 49 4e-06 gi|6912312 claudin 12 [Homo sapiens] 43 4e-04 gi|124107616 claudin 23 [Homo sapiens] 37 0.022 >gi|5729970 claudin 16 [Homo sapiens] Length = 305 Score = 638 bits (1645), Expect = 0.0 Identities = 305/305 (100%), Positives = 305/305 (100%) Query: 1 MTSRTPLLVTACLYYSYCNSRHLQQGVRKSKRPVFSHCQVPETQKTDTRHLSGARAGVCP 60 MTSRTPLLVTACLYYSYCNSRHLQQGVRKSKRPVFSHCQVPETQKTDTRHLSGARAGVCP Sbjct: 1 MTSRTPLLVTACLYYSYCNSRHLQQGVRKSKRPVFSHCQVPETQKTDTRHLSGARAGVCP 60 Query: 61 CCHPDGLLATMRDLLQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKCRGLWWEC 120 CCHPDGLLATMRDLLQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKCRGLWWEC Sbjct: 61 CCHPDGLLATMRDLLQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKCRGLWWEC 120 Query: 121 VTNAFDGIRTCDEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEP 180 VTNAFDGIRTCDEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEP Sbjct: 121 VTNAFDGIRTCDEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEP 180 Query: 181 YIKVRICFVAGATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGM 240 YIKVRICFVAGATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGM Sbjct: 181 YIKVRICFVAGATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGM 240 Query: 241 AGSLGCFLAGAVLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSYSAPRTETAKMYA 300 AGSLGCFLAGAVLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSYSAPRTETAKMYA Sbjct: 241 AGSLGCFLAGAVLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSYSAPRTETAKMYA 300 Query: 301 VDTRV 305 VDTRV Sbjct: 301 VDTRV 305 >gi|153792186 claudin 7 [Homo sapiens] Length = 211 Score = 80.9 bits (198), Expect = 1e-15 Identities = 60/228 (26%), Positives = 101/228 (44%), Gaps = 26/228 (11%) Query: 75 LQYIACFFAFFSAGFLIVATWTDCWMVNA---DDSLEVSTKCRGLWWECVTNAFDGIRTC 131 LQ + A L+ T W +++ D+ + +GLW +CVT + G+ +C Sbjct: 6 LQLLGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQS-TGMMSC 64 Query: 132 DEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAG 191 YDS+LA L TRALM+ + +L +G+ C + D+ K RI G Sbjct: 65 KMYDSVLALSAA-LQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAMGGG 123 Query: 192 ATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGA 251 ++AG ++ WY + + ++ I+Y+FG + ++G AGS L GA Sbjct: 124 IIFIVAGLAALVACSWYGHQIVTDFYNPLIPT---NIKYEFGPAIFIGWAGSALVILGGA 180 Query: 252 VLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSYSAPRTETAKMY 299 +L+C S S AG + +SY P++ ++K Y Sbjct: 181 LLSC----------------SCPGNESKAGYRVPRSY--PKSNSSKEY 210 >gi|10863887 claudin 1 [Homo sapiens] Length = 211 Score = 80.5 bits (197), Expect = 2e-15 Identities = 61/221 (27%), Positives = 96/221 (43%), Gaps = 24/221 (10%) Query: 74 LLQYIACFFAFFSAGFLIVATWTDCWMVNA---DDSLEVSTKCRGLWWECVTNAFDGIRT 130 LL +I F + A IV+T W + + D+ + GLW CV+ + I+ Sbjct: 8 LLGFILAFLGWIGA---IVSTALPQWRIYSYAGDNIVTAQAMYEGLWMSCVSQSTGQIQ- 63 Query: 131 CDEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVA 190 C +DS+L L TRALM+ +L +G+ C+K L D+ K+R+ + Sbjct: 64 CKVFDSLL-NLSSTLQATRALMVVGILLGVIAIFVATVGMKCMKCLEDDEVQKMRMAVIG 122 Query: 191 GATLLIAGTPGIIGSVWYA---VDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCF 247 GA L+AG ++ + WY V + + T V +Y+FG + + G A + C Sbjct: 123 GAIFLLAGLAILVATAWYGNRIVQEFYDPMTPV------NARYEFGQALFTGWAAASLCL 176 Query: 248 LAGAVLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSY 288 L GA+L C P + Y + Y S K Y Sbjct: 177 LGGALLCCSC-------PRKTTSYPTPRPYPKPAPSSGKDY 210 >gi|4502877 claudin 4 [Homo sapiens] Length = 209 Score = 71.6 bits (174), Expect = 8e-13 Identities = 63/193 (32%), Positives = 90/193 (46%), Gaps = 17/193 (8%) Query: 99 WMVNA---DDSLEVSTKCRGLWWECVTNAFDGIRTCDEYDSILAEHPLKLVVTRALMITA 155 W V A + + T GLW CV + G C YDS+LA P L RAL+I + Sbjct: 30 WRVTAFIGSNIVTSQTIWEGLWMNCVVQS-TGQMQCKVYDSLLAL-PQDLQAARALVIIS 87 Query: 156 DILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAGATLLIAGTPGIIGSVWYAVDVYVE 215 I+A G L ++G C L DE K + VAG L+AG I+ W A ++ + Sbjct: 88 IIVAALGVLLSVVGGKCTNCLEDES-AKAKTMIVAGVVFLLAGLMVIVPVSWTAHNIIQD 146 Query: 216 RSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGAVLTCCLYLFKDVGPERNYPYSLRK 275 ++ + G + + G S ++G A S G L G L CC + P + PYS + Sbjct: 147 FYNPLVAS---GQKREMGASLYVGWAAS-GLLLLGGGLLCC-----NCPPRTDKPYSAK- 196 Query: 276 AYSAAGVSMAKSY 288 YSAA + A +Y Sbjct: 197 -YSAARSAAASNY 208 >gi|7656981 claudin 15 [Homo sapiens] Length = 228 Score = 70.1 bits (170), Expect = 2e-12 Identities = 58/198 (29%), Positives = 90/198 (45%), Gaps = 14/198 (7%) Query: 82 FAFFSA--GFLIVATW--TDCWMVNA--DDSLEVSTKCRGLWWECVTNAFDGIRTCDEYD 135 F FF A G L++ W V+ + + +T LW+ C T++ G+ C E+ Sbjct: 8 FGFFMATVGLLMLGVTLPNSYWRVSTVHGNVITTNTIFENLWFSCATDSL-GVYNCWEFP 66 Query: 136 SILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAGATLL 195 S+LA + RALMITA +L G L + GL C E K ++ AGA + Sbjct: 67 SMLALSGY-IQACRALMITAILLGFLGLLLGIAGLRCTNIGGLELSRKAKLAATAGALHI 125 Query: 196 IAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGAVL-- 253 +AG G++ WYA ++ + ++ G +Y+ G + +LG + SL L G L Sbjct: 126 LAGICGMVAISWYAFNITRD----FFDPLYPGTKYELGPALYLGWSASLISILGGLCLCS 181 Query: 254 TCCLYLFKDVGPERNYPY 271 CC +D PY Sbjct: 182 ACCCGSDEDPAASARRPY 199 >gi|10938016 claudin 11 [Homo sapiens] Length = 207 Score = 68.9 bits (167), Expect = 5e-12 Identities = 55/208 (26%), Positives = 93/208 (44%), Gaps = 22/208 (10%) Query: 67 LLATMRDLLQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKC-----RGLWWECV 121 ++AT ++ ++ F + +IV T T+ W+V ++ K +GLW +CV Sbjct: 1 MVATCLQVVGFVTSFVGWIG---VIVTTSTNDWVVTCGYTIPTCRKLDELGSKGLWADCV 57 Query: 122 TNAFDGIRTCDEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPY 181 G+ C IL P + RALMI A +L L LL L C++ + Sbjct: 58 MAT--GLYHCKPLVDILIL-PGYVQACRALMIAASVLGLPAILLLLTVLPCIRMGQEPGV 114 Query: 182 IKVRICFVAGATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMA 241 K R +AG L++ ++ ++W+ V + E +T+V FG+S + G Sbjct: 115 AKYRRAQLAGVLLILLALCALVATIWFPVCAHRE-TTIV----------SFGYSLYAGWI 163 Query: 242 GSLGCFLAGAVLTCCLYLFKDVGPERNY 269 G++ C + G V+ CC + G R Y Sbjct: 164 GAVLCLVGGCVILCCAGDAQAFGENRFY 191 >gi|5921465 claudin 10 isoform b [Homo sapiens] Length = 228 Score = 65.1 bits (157), Expect = 7e-11 Identities = 50/178 (28%), Positives = 83/178 (46%), Gaps = 10/178 (5%) Query: 78 IACFFAFFSAGFLIVATW-TDCWMVNADDSLEVSTKC--RGLWWECVTNAFDGIRTCDEY 134 I F S L+ +T TD W V+ D ++T LW CVT++ G+ C ++ Sbjct: 8 IIAFMVSISGWVLVSSTLPTDYWKVSTIDGTVITTATYWANLWKACVTDS-TGVSNCKDF 66 Query: 135 DSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAGATL 194 S+LA + R LMI A L FG + L G+ C K + K +I +AG Sbjct: 67 PSMLALDGY-IQACRGLMIAAVSLGFFGSIFALFGMKCTK-VGGSDKAKAKIACLAGIVF 124 Query: 195 LIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGAV 252 +++G + G YA + +T +F+ +Y+ G + ++G AG+ C + G + Sbjct: 125 ILSGLCSMTGCSLYANKI----TTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVI 178 >gi|4502875 claudin 3 [Homo sapiens] Length = 220 Score = 64.3 bits (155), Expect = 1e-10 Identities = 60/206 (29%), Positives = 85/206 (41%), Gaps = 26/206 (12%) Query: 91 IVATWTDCWMVNADDSLEVSTK---CRGLWWECVTNAFDGIRTCDEYDSILAEHPLKLVV 147 IV W V+A + T GLW CV + G C YDS+LA P L Sbjct: 21 IVCCALPMWRVSAFIGSNIITSQNIWEGLWMNCVVQS-TGQMQCKVYDSLLAL-PQDLQA 78 Query: 148 TRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAGATLLIAGTPGIIGSVW 207 RAL++ A +LA FG L L+G C + D+ K +I VAG L+A ++ W Sbjct: 79 ARALIVVAILLAAFGLLVALVGAQCTNCVQDDT-AKAKITIVAGVLFLLAALLTLVPVSW 137 Query: 208 YAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGAVLTCCLYLFKDVGPER 267 A + + V+ + + G ++G A + L GA+L C P R Sbjct: 138 SANTIIRDFYNPVVPE---AQKREMGAGLYVGWAAAALQLLGGALLCCSC-------PPR 187 Query: 268 NYPYSLRKAYSAAGVSMAKSYSAPRT 293 Y+ K YSAPR+ Sbjct: 188 EKKYTATKVV----------YSAPRS 203 >gi|47716519 claudin 20 [Homo sapiens] Length = 219 Score = 63.5 bits (153), Expect = 2e-10 Identities = 48/187 (25%), Positives = 84/187 (44%), Gaps = 10/187 (5%) Query: 75 LQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVST---KCRGLWWECVTNAFDGIRTC 131 LQ +A A ++ AT W VN D + T + GLW +C T G+ +C Sbjct: 6 LQLLAFILALSGVSGVLTATLLPNWKVNVDVDSNIITAIVQLHGLWMDC-TWYSTGMFSC 64 Query: 132 DEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAG 191 SIL+ P+ + RA M+ A +L+ G T +G+ C + L + K F G Sbjct: 65 ALKHSILS-LPIHVQAARATMVLACVLSALGICTSTVGMKCTR-LGGDRETKSHASFAGG 122 Query: 192 ATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGA 251 + AG +I +VWY ++ L + +++ G + ++G ++ F++G Sbjct: 123 VCFMSAGISSLISTVWYTKEIIANFLDLTVPE---SNKHEPGGAIYIGFISAMLLFISGM 179 Query: 252 VL-TCCL 257 + T C+ Sbjct: 180 IFCTSCI 186 >gi|183979975 claudin 19 isoform b [Homo sapiens] Length = 211 Score = 62.4 bits (150), Expect = 5e-10 Identities = 57/222 (25%), Positives = 90/222 (40%), Gaps = 25/222 (11%) Query: 75 LQYIACFFAFFSAGFLIVATWTDCWMVNA---DDSLEVSTKCRGLWWECVTNAFDGIRTC 131 LQ + F A +I +T W ++ D + GLW C + + ++ C Sbjct: 6 LQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQ-C 64 Query: 132 DEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAG 191 YDS+LA + RALM+ A +L + ++G+ C + P K R+ G Sbjct: 65 KLYDSLLALDG-HIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAIAGG 123 Query: 192 ATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIF-----LGIQYKFGWSCWLGMAGSLGC 246 A ++AG + WYA TLV F + +Y+FG + ++G A S G Sbjct: 124 ALFILAGLCTLTAVSWYA--------TLVTQEFFNPSTPVNARYEFGPALFVGWA-SAGL 174 Query: 247 FLAGAVLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSY 288 + G CC PE P S + Y + A+ Y Sbjct: 175 AVLGGSFLCC------TCPEPERPNSSPQPYRPGPSAAAREY 210 >gi|40788011 claudin 8 [Homo sapiens] Length = 225 Score = 62.0 bits (149), Expect = 6e-10 Identities = 47/162 (29%), Positives = 72/162 (44%), Gaps = 14/162 (8%) Query: 115 GLWWECVTNAFDGIRT-CDEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCV 173 GLW CV A IR C YDS+LA P L R LM A +++ F+ +LG+ C Sbjct: 49 GLWMNCVRQA--NIRMQCKIYDSLLALSP-DLQAARGLMCAASVMSFLAFMMAILGMKCT 105 Query: 174 KFLPDEPYIKVRICFVAGATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYK-- 231 + D +K I AG +I G +I W A + + +N + + K Sbjct: 106 RCTGDNEKVKAHILLTAGIIFIITGMVVLIPVSWVANAIIRD-----FYNSIVNVAQKRE 160 Query: 232 FGWSCWLGMAGSLGCFLAGAVLTCCLYLFKDVGPERNYPYSL 273 G + +LG +L + G L CC++ + +Y YS+ Sbjct: 161 LGEALYLGWTTAL-VLIVGGALFCCVFCCNE--KSSSYRYSI 199 >gi|11141861 claudin 9 [Homo sapiens] Length = 217 Score = 61.6 bits (148), Expect = 8e-10 Identities = 49/142 (34%), Positives = 66/142 (46%), Gaps = 8/142 (5%) Query: 115 GLWWECVTNAFDGIRTCDEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVK 174 GLW CV + G C YDS+LA P L RAL + A +LA G L + G C Sbjct: 49 GLWMSCVVQS-TGQMQCKVYDSLLAL-PQDLQAARALCVIALLLALLGLLVAITGAQCTT 106 Query: 175 FLPDEPYIKVRICFVAGATLLIAGTPGIIGSVWYAVDVYVE-RSTLVLHNIFLGIQYKFG 233 + DE K RI AG LL+AG +I W A + + + LV ++ + G Sbjct: 107 CVEDEG-AKARIVLTAGVILLLAGILVLIPVCWTAHAIIQDFYNPLVAE----ALKRELG 161 Query: 234 WSCWLGMAGSLGCFLAGAVLTC 255 S +LG A + L G +L C Sbjct: 162 ASLYLGWAAAALLMLGGGLLCC 183 >gi|225703142 claudin 14 [Homo sapiens] Length = 239 Score = 60.8 bits (146), Expect = 1e-09 Identities = 55/220 (25%), Positives = 92/220 (41%), Gaps = 14/220 (6%) Query: 75 LQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKC---RGLWWECVTNAFDGIRTC 131 +Q + +F ++ T W A + T +GLW ECV ++ GI C Sbjct: 6 VQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHS-TGIYQC 64 Query: 132 DEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAG 191 Y S+LA P L RALM+ + +L+G ++G+ C + P K + G Sbjct: 65 QIYRSLLAL-PQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTP-AKTTFAILGG 122 Query: 192 ATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGA 251 ++AG ++ W DV +L + G++++ G + +LG S + G Sbjct: 123 TLFILAGLLCMVAVSWTTNDVVQNFYNPLLPS---GMKFEIGQALYLGFISSSLSLIGGT 179 Query: 252 VLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSYSAP 291 +L CL +D P R PY + + A +Y P Sbjct: 180 LL--CLSC-QDEAPYR--PYQAPPRATTTTANTAPAYQPP 214 >gi|21536294 claudin 14 [Homo sapiens] Length = 239 Score = 60.8 bits (146), Expect = 1e-09 Identities = 55/220 (25%), Positives = 92/220 (41%), Gaps = 14/220 (6%) Query: 75 LQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKC---RGLWWECVTNAFDGIRTC 131 +Q + +F ++ T W A + T +GLW ECV ++ GI C Sbjct: 6 VQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHS-TGIYQC 64 Query: 132 DEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAG 191 Y S+LA P L RALM+ + +L+G ++G+ C + P K + G Sbjct: 65 QIYRSLLAL-PQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTP-AKTTFAILGG 122 Query: 192 ATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGA 251 ++AG ++ W DV +L + G++++ G + +LG S + G Sbjct: 123 TLFILAGLLCMVAVSWTTNDVVQNFYNPLLPS---GMKFEIGQALYLGFISSSLSLIGGT 179 Query: 252 VLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSYSAP 291 +L CL +D P R PY + + A +Y P Sbjct: 180 LL--CLSC-QDEAPYR--PYQAPPRATTTTANTAPAYQPP 214 >gi|225703138 claudin 14 [Homo sapiens] Length = 239 Score = 60.8 bits (146), Expect = 1e-09 Identities = 55/220 (25%), Positives = 92/220 (41%), Gaps = 14/220 (6%) Query: 75 LQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKC---RGLWWECVTNAFDGIRTC 131 +Q + +F ++ T W A + T +GLW ECV ++ GI C Sbjct: 6 VQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHS-TGIYQC 64 Query: 132 DEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAG 191 Y S+LA P L RALM+ + +L+G ++G+ C + P K + G Sbjct: 65 QIYRSLLAL-PQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTP-AKTTFAILGG 122 Query: 192 ATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGA 251 ++AG ++ W DV +L + G++++ G + +LG S + G Sbjct: 123 TLFILAGLLCMVAVSWTTNDVVQNFYNPLLPS---GMKFEIGQALYLGFISSSLSLIGGT 179 Query: 252 VLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSYSAP 291 +L CL +D P R PY + + A +Y P Sbjct: 180 LL--CLSC-QDEAPYR--PYQAPPRATTTTANTAPAYQPP 214 >gi|6912314 claudin 14 [Homo sapiens] Length = 239 Score = 60.8 bits (146), Expect = 1e-09 Identities = 55/220 (25%), Positives = 92/220 (41%), Gaps = 14/220 (6%) Query: 75 LQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKC---RGLWWECVTNAFDGIRTC 131 +Q + +F ++ T W A + T +GLW ECV ++ GI C Sbjct: 6 VQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHS-TGIYQC 64 Query: 132 DEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAG 191 Y S+LA P L RALM+ + +L+G ++G+ C + P K + G Sbjct: 65 QIYRSLLAL-PQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTP-AKTTFAILGG 122 Query: 192 ATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGA 251 ++AG ++ W DV +L + G++++ G + +LG S + G Sbjct: 123 TLFILAGLLCMVAVSWTTNDVVQNFYNPLLPS---GMKFEIGQALYLGFISSSLSLIGGT 179 Query: 252 VLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSYSAP 291 +L CL +D P R PY + + A +Y P Sbjct: 180 LL--CLSC-QDEAPYR--PYQAPPRATTTTANTAPAYQPP 214 >gi|225703140 claudin 14 [Homo sapiens] Length = 239 Score = 60.8 bits (146), Expect = 1e-09 Identities = 55/220 (25%), Positives = 92/220 (41%), Gaps = 14/220 (6%) Query: 75 LQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKC---RGLWWECVTNAFDGIRTC 131 +Q + +F ++ T W A + T +GLW ECV ++ GI C Sbjct: 6 VQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHS-TGIYQC 64 Query: 132 DEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAG 191 Y S+LA P L RALM+ + +L+G ++G+ C + P K + G Sbjct: 65 QIYRSLLAL-PQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTP-AKTTFAILGG 122 Query: 192 ATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGA 251 ++AG ++ W DV +L + G++++ G + +LG S + G Sbjct: 123 TLFILAGLLCMVAVSWTTNDVVQNFYNPLLPS---GMKFEIGQALYLGFISSSLSLIGGT 179 Query: 252 VLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSYSAP 291 +L CL +D P R PY + + A +Y P Sbjct: 180 LL--CLSC-QDEAPYR--PYQAPPRATTTTANTAPAYQPP 214 >gi|169167239 PREDICTED: claudin-24-like [Homo sapiens] Length = 220 Score = 60.1 bits (144), Expect = 2e-09 Identities = 48/184 (26%), Positives = 79/184 (42%), Gaps = 4/184 (2%) Query: 72 RDLLQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKCRGLWWECVTNAFDGIRTC 131 R +Q + +F I+ T+ W D E+ GLW CV G++ C Sbjct: 6 RTAMQSVGLLLSFLGWILSIITTYLPHWKNLNLDLNEMENWTMGLWQTCVIQEEVGMQ-C 64 Query: 132 DEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAG 191 ++DS LA P +L V+R LM ++ L G L GLDC++ + +K R+ + G Sbjct: 65 KDFDSFLAL-PAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGG 123 Query: 192 ATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGA 251 +G ++ W A E + + +++FG + +LG L L G Sbjct: 124 ILSWASGITALVPVSWVAHKTVQEFWDENVPDFV--PRWEFGEALFLGWFAGLSLLLGGC 181 Query: 252 VLTC 255 +L C Sbjct: 182 LLNC 185 >gi|169166931 PREDICTED: claudin-24-like [Homo sapiens] Length = 220 Score = 60.1 bits (144), Expect = 2e-09 Identities = 48/184 (26%), Positives = 79/184 (42%), Gaps = 4/184 (2%) Query: 72 RDLLQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKCRGLWWECVTNAFDGIRTC 131 R +Q + +F I+ T+ W D E+ GLW CV G++ C Sbjct: 6 RTAMQSVGLLLSFLGWILSIITTYLPHWKNLNLDLNEMENWTMGLWQTCVIQEEVGMQ-C 64 Query: 132 DEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAG 191 ++DS LA P +L V+R LM ++ L G L GLDC++ + +K R+ + G Sbjct: 65 KDFDSFLAL-PAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGG 123 Query: 192 ATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGA 251 +G ++ W A E + + +++FG + +LG L L G Sbjct: 124 ILSWASGITALVPVSWVAHKTVQEFWDENVPDFV--PRWEFGEALFLGWFAGLSLLLGGC 181 Query: 252 VLTC 255 +L C Sbjct: 182 LLNC 185 >gi|7705961 claudin 18 isoform 1 [Homo sapiens] Length = 261 Score = 59.7 bits (143), Expect = 3e-09 Identities = 58/222 (26%), Positives = 91/222 (40%), Gaps = 21/222 (9%) Query: 76 QYIACFFAFFSAGFLIVATWTDCWMVNA--DDSLEVSTKCRGLWWECVTNAFDGIRTCDE 133 Q +A + I AT D W D+ + + GLW CV + G C Sbjct: 7 QVVAFLLSILGLAGCIAATGMDMWSTQDLYDNPVTSVFQYEGLWRSCVRQS-SGFTECRP 65 Query: 134 YDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAGAT 193 Y +IL P L RALMI +L G L + L C++ E K + +G Sbjct: 66 YFTILGL-PAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIM 124 Query: 194 LLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGI---------QYKFGWSCWLGMAGSL 244 +++G I G +A ++ V + N++ G+ +Y FG + ++G Sbjct: 125 FIVSGLCAIAGVSVFA-NMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAG- 182 Query: 245 GCFLAGAVLTCCLYLFKDVGPER-NYPYSLRKAYSAAGVSMA 285 G L G V+ C + + PE NY +Y A+G S+A Sbjct: 183 GLTLIGGVMMC--IACRGLAPEETNYK---AVSYHASGHSVA 219 >gi|183979973 claudin 19 isoform a [Homo sapiens] Length = 224 Score = 59.7 bits (143), Expect = 3e-09 Identities = 50/190 (26%), Positives = 80/190 (42%), Gaps = 19/190 (10%) Query: 75 LQYIACFFAFFSAGFLIVATWTDCWMVNA---DDSLEVSTKCRGLWWECVTNAFDGIRTC 131 LQ + F A +I +T W ++ D + GLW C + + ++ C Sbjct: 6 LQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQ-C 64 Query: 132 DEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAG 191 YDS+LA + RALM+ A +L + ++G+ C + P K R+ G Sbjct: 65 KLYDSLLALDG-HIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAIAGG 123 Query: 192 ATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIF-----LGIQYKFGWSCWLGMAGSLGC 246 A ++AG + WYA TLV F + +Y+FG + ++G A S G Sbjct: 124 ALFILAGLCTLTAVSWYA--------TLVTQEFFNPSTPVNARYEFGPALFVGWA-SAGL 174 Query: 247 FLAGAVLTCC 256 + G CC Sbjct: 175 AVLGGSFLCC 184 >gi|153792768 claudin 6 [Homo sapiens] Length = 220 Score = 58.2 bits (139), Expect = 9e-09 Identities = 55/175 (31%), Positives = 75/175 (42%), Gaps = 13/175 (7%) Query: 115 GLWWECVTNAFDGIRTCDEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVK 174 GLW CV + G C YDS+LA P L RAL + A ++A FG L L G C Sbjct: 49 GLWMSCVVQS-TGQMQCKVYDSLLAL-PQDLQAARALCVIALLVALFGLLVYLAGAKCTT 106 Query: 175 FLPDEPYIKVRICFVAGATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYK--F 232 + +E K R+ +G +I+G +I W A + + +N + K Sbjct: 107 CV-EEKDSKARLVLTSGIVFVISGVLTLIPVCWTAHAIIRD-----FYNPLVAEAQKREL 160 Query: 233 GWSCWLGMAGSLGCFLAGAVLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKS 287 G S +LG A S G L G L CC G + Y R + SA +S S Sbjct: 161 GASLYLGWAAS-GLLLLGGGLLCC--TCPSGGSQGPSHYMARYSTSAPAISRGPS 212 >gi|169166402 PREDICTED: claudin-24-like [Homo sapiens] Length = 220 Score = 57.8 bits (138), Expect = 1e-08 Identities = 47/184 (25%), Positives = 78/184 (42%), Gaps = 4/184 (2%) Query: 72 RDLLQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKCRGLWWECVTNAFDGIRTC 131 R +Q + + I+ T+ W D E+ GLW CV G++ C Sbjct: 6 RTAMQSVGLLLSLLGWILSIITTYLPHWKNLNLDLNEMENWTMGLWQTCVIQEEVGMQ-C 64 Query: 132 DEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAG 191 ++DS LA P +L V+R LM ++ L G L GLDC++ + +K R+ + G Sbjct: 65 KDFDSFLAL-PAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGG 123 Query: 192 ATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGA 251 +G ++ W A E + + +++FG + +LG L L G Sbjct: 124 ILSWASGITALVPVSWVAHKTVQEFWDENVPDFV--PRWEFGEALFLGWFAGLSLLLGGC 181 Query: 252 VLTC 255 +L C Sbjct: 182 LLNC 185 >gi|9966781 claudin 2 [Homo sapiens] Length = 230 Score = 57.0 bits (136), Expect = 2e-08 Identities = 35/140 (25%), Positives = 69/140 (49%), Gaps = 6/140 (4%) Query: 114 RGLWWECVTNAFDGIRTCDEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCV 173 +GLW EC T++ GI CD Y ++L P + +A+M+T+ ++ + ++G+ C Sbjct: 48 KGLWMECATHS-TGITQCDIYSTLLG-LPADIQAAQAMMVTSSAISSLACIISVVGMRCT 105 Query: 174 KFLPDEPYIKVRICFVAGATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFG 233 F E K R+ G ++ G G I W + + + ++ + ++++ G Sbjct: 106 VFC-QESRAKDRVAVAGGVFFILGGLLGFIPVAWNLHGILRDFYSPLVPD---SMKFEIG 161 Query: 234 WSCWLGMAGSLGCFLAGAVL 253 + +LG+ SL +AG +L Sbjct: 162 EALYLGIISSLFSLIAGIIL 181 >gi|33598916 claudin 10 isoform a [Homo sapiens] Length = 226 Score = 55.8 bits (133), Expect = 5e-08 Identities = 44/167 (26%), Positives = 74/167 (44%), Gaps = 9/167 (5%) Query: 88 GFLIVATWTDCWMVN--ADDSLEVSTKCRGLWWECVTNAFDGIRTCDEYDSILAEHPLKL 145 G L+ AT ++ W V A + + +GLW C NA C + +I + Sbjct: 17 GALVAATTSNEWKVTTRASSVITATWVYQGLWMNCAGNALGSFH-CRPHFTIFKVAGY-I 74 Query: 146 VVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAGATLLIAGTPGIIGS 205 R LMI A L FG + L G+ C K + K +I +AG +++G + G Sbjct: 75 QACRGLMIAAVSLGFFGSIFALFGMKCTK-VGGSDKAKAKIACLAGIVFILSGLCSMTGC 133 Query: 206 VWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGAV 252 YA + +T +F+ +Y+ G + ++G AG+ C + G + Sbjct: 134 SLYANKI----TTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVI 176 >gi|50345279 claudin 18 isoform 2 [Homo sapiens] Length = 261 Score = 55.5 bits (132), Expect = 6e-08 Identities = 54/208 (25%), Positives = 88/208 (42%), Gaps = 21/208 (10%) Query: 90 LIVATWTDCWMVNA--DDSLEVSTKCRGLWWECVTNAFDGIRTCDEYDSILAEHPLKLVV 147 +I AT D W ++ + +GLW CV + G C Y ++L P L Sbjct: 21 IIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRES-SGFTECRGYFTLLGL-PAMLQA 78 Query: 148 TRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAGATLLIAGTPGIIGSVW 207 RALMI +L G L + L C++ E K + +G +++G I G Sbjct: 79 VRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSV 138 Query: 208 YAVDVYVERSTLVLHNIFLGI---------QYKFGWSCWLGMAGSLGCFLAGAVLTCCLY 258 +A ++ V + N++ G+ +Y FG + ++G G L G V+ C Sbjct: 139 FA-NMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAG-GLTLIGGVMMC--I 194 Query: 259 LFKDVGPER-NYPYSLRKAYSAAGVSMA 285 + + PE NY +Y A+G S+A Sbjct: 195 ACRGLAPEETNYK---AVSYHASGHSVA 219 >gi|162417973 claudin 22 [Homo sapiens] Length = 220 Score = 53.9 bits (128), Expect = 2e-07 Identities = 42/151 (27%), Positives = 68/151 (45%), Gaps = 4/151 (2%) Query: 105 DSLEVSTKCRGLWWECVTNAFDGIRTCDEYDSILAEHPLKLVVTRALMITADILAGFGFL 164 D E+ GLW CV G++ C ++DS LA P +L V+R LM ++ L G L Sbjct: 39 DLNEMENWTMGLWQTCVIQEEVGMQ-CKDFDSFLAL-PAELRVSRILMFLSNGLGFLGLL 96 Query: 165 TLLLGLDCVKFLPDEPYIKVRICFVAGATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNI 224 GLDC++ + +K R+ + G +G ++ W A E + + Sbjct: 97 VSGFGLDCLRIGESQRDLKRRLLILGGILSWASGVTALVPVSWVAHKTVQEFWDENVPDF 156 Query: 225 FLGIQYKFGWSCWLGMAGSLGCFLAGAVLTC 255 +++FG + +LG L L G +L C Sbjct: 157 V--PRWEFGEALFLGWFAGLSLLLGGCLLHC 185 >gi|231569235 claudin 10 isoform a_i1 [Homo sapiens] Length = 207 Score = 49.3 bits (116), Expect = 4e-06 Identities = 42/167 (25%), Positives = 70/167 (41%), Gaps = 28/167 (16%) Query: 88 GFLIVATWTDCWMVN--ADDSLEVSTKCRGLWWECVTNAFDGIRTCDEYDSILAEHPLKL 145 G L+ AT ++ W V A + + +GLW C I+ C Sbjct: 17 GALVAATTSNEWKVTTRASSVITATWVYQGLWMNCAGY----IQAC-------------- 58 Query: 146 VVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVAGATLLIAGTPGIIGS 205 R LMI A L FG + L G+ C K + K +I +AG +++G + G Sbjct: 59 ---RGLMIAAVSLGFFGSIFALFGMKCTK-VGGSDKAKAKIACLAGIVFILSGLCSMTGC 114 Query: 206 VWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGAV 252 YA + +T +F+ +Y+ G + ++G AG+ C + G + Sbjct: 115 SLYANKI----TTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVI 157 >gi|6912312 claudin 12 [Homo sapiens] Length = 244 Score = 42.7 bits (99), Expect = 4e-04 Identities = 46/199 (23%), Positives = 82/199 (41%), Gaps = 29/199 (14%) Query: 69 ATMRDLLQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKCRGLWWECVTNAFDGI 128 AT+ L IA F+ L W ++ + + + T GLW +C +DG Sbjct: 9 ATVLSFLCGIASVAGLFAGTLL--PNWRKLRLITFNRNEKNLTVYTGLWVKCAR--YDGS 64 Query: 129 RTCDEYDSIL--AEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRI 186 C YD+ + L L V + + + ++A L L+G+ F P IK+ Sbjct: 65 SDCLMYDTTWYSSVDQLDLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIKLAK 124 Query: 187 CFV--------AGATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYK----FGW 234 C V AG +AGT + S+W ++ +NI L +++ F + Sbjct: 125 CLVNSAGCHLVAGLLFFLAGTVSLSPSIW-----------VIFYNIHLNKKFEPVFSFDY 173 Query: 235 SCWLGMAGSLGCFLAGAVL 253 + ++ +A + G F+ +L Sbjct: 174 AVYVTIASAGGLFMTSLIL 192 >gi|124107616 claudin 23 [Homo sapiens] Length = 292 Score = 37.0 bits (84), Expect = 0.022 Identities = 29/95 (30%), Positives = 43/95 (45%), Gaps = 6/95 (6%) Query: 114 RGLWWECVTNAFDGIRTCDEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCV 173 +GLW C + R C + D ++V RALM+T+ G L LG+ C Sbjct: 47 QGLWDMCREQS-SRERECGQTDQWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCW 105 Query: 174 KFLPDEPYIKVRICFVAGATLLIAGTPGIIGSVWY 208 + DEP + ++G L +AG G+I WY Sbjct: 106 Q---DEP--NFVLAGLSGVVLFVAGLLGLIPVSWY 135 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.327 0.140 0.462 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 11,169,424 Number of Sequences: 37866 Number of extensions: 464448 Number of successful extensions: 1139 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 16 Number of HSP's successfully gapped in prelim test: 21 Number of HSP's that attempted gapping in prelim test: 1097 Number of HSP's gapped (non-prelim): 37 length of query: 305 length of database: 18,247,518 effective HSP length: 102 effective length of query: 203 effective length of database: 14,385,186 effective search space: 2920192758 effective search space used: 2920192758 T: 11 A: 40 X1: 15 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.7 bits) S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.