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Search of human proteins with 5729852
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
isoform a [Homo sapiens]
(353 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is... 728 0.0
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i... 728 0.0
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 374 e-104
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 372 e-103
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [... 369 e-102
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H... 368 e-102
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 125 7e-29
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 125 7e-29
gi|21071067 TBP-associated factor 5 [Homo sapiens] 117 2e-26
gi|32189425 WD repeat domain 69 [Homo sapiens] 109 4e-24
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 106 4e-23
gi|26665869 WD repeat domain 51B [Homo sapiens] 105 8e-23
gi|16554629 WD repeat domain 5 [Homo sapiens] 104 1e-22
gi|16554627 WD repeat domain 5 [Homo sapiens] 104 1e-22
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 103 2e-22
gi|23199987 WD repeat domain 5B [Homo sapiens] 103 2e-22
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 103 3e-22
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 103 3e-22
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 100 2e-21
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 100 2e-21
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 100 2e-21
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 100 2e-21
gi|19913367 transducin beta-like 1Y [Homo sapiens] 100 2e-21
gi|19913365 transducin beta-like 1Y [Homo sapiens] 100 2e-21
gi|15150805 transducin beta-like 1Y [Homo sapiens] 100 2e-21
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 99 4e-21
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 99 4e-21
gi|113865883 WD repeat domain 38 [Homo sapiens] 99 6e-21
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens] 99 6e-21
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 98 1e-20
>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
isoform a [Homo sapiens]
Length = 353
Score = 728 bits (1878), Expect = 0.0
Identities = 353/353 (100%), Positives = 353/353 (100%)
Query: 1 MATEGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLK 60
MATEGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLK
Sbjct: 1 MATEGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLK 60
Query: 61 GHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAI 120
GHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAI
Sbjct: 61 GHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAI 120
Query: 121 ACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALW 180
ACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALW
Sbjct: 121 ACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALW 180
Query: 181 DVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHES 240
DVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHES
Sbjct: 181 DVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHES 240
Query: 241 DINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFA 300
DINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFA
Sbjct: 241 DINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFA 300
Query: 301 GYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 353
GYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA
Sbjct: 301 GYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 353
>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
isoform b [Homo sapiens]
Length = 395
Score = 728 bits (1878), Expect = 0.0
Identities = 353/353 (100%), Positives = 353/353 (100%)
Query: 1 MATEGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLK 60
MATEGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLK
Sbjct: 43 MATEGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLK 102
Query: 61 GHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAI 120
GHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAI
Sbjct: 103 GHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAI 162
Query: 121 ACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALW 180
ACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALW
Sbjct: 163 ACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALW 222
Query: 181 DVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHES 240
DVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHES
Sbjct: 223 DVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHES 282
Query: 241 DINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFA 300
DINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFA
Sbjct: 283 DINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFA 342
Query: 301 GYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 353
GYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA
Sbjct: 343 GYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 395
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 374 bits (961), Expect = e-104
Identities = 180/341 (52%), Positives = 234/341 (68%), Gaps = 5/341 (1%)
Query: 12 LASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDW 71
L L+ EAE LK ++ + R D L Q+ ++ +G+ M+TRRTL+GH K+ M W
Sbjct: 4 LDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHW 63
Query: 72 CKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSV 131
D R +VS+SQDGK+I+WDS+TTNK HA+ + +WVM CAYAPSG +ACGGLDN CS+
Sbjct: 64 GTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSI 123
Query: 132 YPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSF 191
Y L E + +A HT YLS C F + D QI+T+SGD TCALWD+E+GQ +F
Sbjct: 124 YNLK--TREGNVRVSRELAGHTGYLSCCRFLD-DNQIVTSSGDTTCALWDIETGQQTTTF 180
Query: 192 HGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSG 251
GH DV+ L LAP FVSG CD A +WD+R G C Q F HESDIN++ ++P+G
Sbjct: 181 TGHTGDVMSLSLAPDT--RLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNG 238
Query: 252 DAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWD 311
+AFA+GSDDATCRL+DLRAD+E+ YS ++II G +SV FS SGRLL AGY+D+ NVWD
Sbjct: 239 NAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWD 298
Query: 312 VLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
LK R +L GH+NRVS L V+ DG A +GSWD L++W
Sbjct: 299 ALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339
>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
[Homo sapiens]
Length = 340
Score = 372 bits (955), Expect = e-103
Identities = 178/341 (52%), Positives = 237/341 (69%), Gaps = 5/341 (1%)
Query: 12 LASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDW 71
L L+ EAE L+ ++++ R +D L Q+ ++++G+ M+TRRTL+GH K+ M W
Sbjct: 4 LEQLRQEAEQLRNQIQDARKACNDATLVQITSNMDSVGRIQMRTRRTLRGHLAKIYAMHW 63
Query: 72 CKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSV 131
D R +VS+SQDGK+I+WDS+TTNK HA+ + +WVM CAYAPSG +ACGGLDN CS+
Sbjct: 64 GYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSI 123
Query: 132 YPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSF 191
Y L E + + HT YLS C F + D QI+T+SGD TCALWD+E+ Q +F
Sbjct: 124 YNLK--TREGNVRVSRELPGHTGYLSCCRFLD-DSQIVTSSGDTTCALWDIETAQQTTTF 180
Query: 192 HGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSG 251
GH DV+ L L+P TFVSG CD + +WD+R G C Q+F H SDIN+V ++P+G
Sbjct: 181 TGHSGDVMSLSLSPDM--RTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNG 238
Query: 252 DAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWD 311
AFA+GSDDATCRL+DLRAD+E+ +YS ++II G +SV FS SGRLL AGY+D+ NVWD
Sbjct: 239 YAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWD 298
Query: 312 VLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
LKG R +L GH+NRVS L V+ DG A +GSWD LR+W
Sbjct: 299 TLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIW 339
>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
[Homo sapiens]
Length = 340
Score = 369 bits (946), Expect = e-102
Identities = 177/341 (51%), Positives = 232/341 (68%), Gaps = 5/341 (1%)
Query: 12 LASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDW 71
L L+ EAE L+ ++ + R D L Q+ ++ +G+ M+TRRTL+GH K+ M W
Sbjct: 4 LEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYAMHW 63
Query: 72 CKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSV 131
D R +VS+SQDGK+I+WDS+TTNK HA+ + +WVM CAYAPSG +ACGGLDN CS+
Sbjct: 64 GTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSI 123
Query: 132 YPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSF 191
Y L E + + HT YLS C F + D QI+T+SGD TCALWD+E+GQ F
Sbjct: 124 YSLK--TREGNVRVSRELPGHTGYLSCCRFLD-DNQIITSSGDTTCALWDIETGQQTVGF 180
Query: 192 HGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSG 251
GH DV+ L LAP G TFVSG CD +WD+R C Q F HESDIN+V ++P+G
Sbjct: 181 AGHSGDVMSLSLAPD--GRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNG 238
Query: 252 DAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWD 311
AF +GSDDATCRL+DLRAD+E+ +YS ++II G +SV FS SGRLL AGY+D+ N+WD
Sbjct: 239 YAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWD 298
Query: 312 VLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
+KG R +L GH+NRVS L V+ DG A +GSWD L++W
Sbjct: 299 AMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339
Score = 64.3 bits (155), Expect = 2e-10
Identities = 49/215 (22%), Positives = 92/215 (42%), Gaps = 7/215 (3%)
Query: 53 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACA 112
++ R L GH + C + D + I++SS D +WD T + VM+ +
Sbjct: 133 VRVSRELPGHTGYLSCCRFLDDNQ-IITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLS 191
Query: 113 YAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTAS 172
AP G G D ++ D ++M +++ H + ++A +F + T S
Sbjct: 192 LAPDGRTFVSGACDASIKLW----DVRDSMC--RQTFIGHESDINAVAFFPNGYAFTTGS 245
Query: 173 GDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCV 232
D TC L+D+ + Q L + +A S +G ++G D +WD G
Sbjct: 246 DDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRA 305
Query: 233 QAFETHESDINSVRYYPSGDAFASGSDDATCRLYD 267
H++ ++ + G A A+GS D+ ++++
Sbjct: 306 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
sapiens]
Length = 340
Score = 368 bits (944), Expect = e-102
Identities = 178/341 (52%), Positives = 234/341 (68%), Gaps = 5/341 (1%)
Query: 12 LASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDW 71
+ L+ EAE LK ++ + R DV L ++ +E +G+ M+TRRTL+GH K+ M W
Sbjct: 4 MEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHW 63
Query: 72 CKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSV 131
D + +VS+SQDGK+IVWDS+TTNK HA+ + +WVM CAYAPSG +ACGGLDN CS+
Sbjct: 64 ATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSI 123
Query: 132 YPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSF 191
Y L E + ++ HT YLS C F + D I+T+SGD TCALWD+E+GQ F
Sbjct: 124 YNLK--SREGNVKVSRELSAHTGYLSCCRFLD-DNNIVTSSGDTTCALWDIETGQQKTVF 180
Query: 192 HGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSG 251
GH D C+ LA S N F+SG CD A +WD+R G C Q F HESDIN++ ++P+G
Sbjct: 181 VGHTGD--CMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNG 238
Query: 252 DAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWD 311
+A +GSDDA+CRL+DLRAD+E+ +S ESII G +SV FSLSGRLLFAGY+D+ NVWD
Sbjct: 239 EAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWD 298
Query: 312 VLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
+K RV IL GH+NRVS L V+ DG A +GSWD L++W
Sbjct: 299 SMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIW 339
Score = 56.2 bits (134), Expect = 4e-08
Identities = 50/215 (23%), Positives = 87/215 (40%), Gaps = 7/215 (3%)
Query: 53 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACA 112
+K R L H + C + D IV+SS D +WD T ++ M+ A
Sbjct: 133 VKVSRELSAHTGYLSCCRFLDDNN-IVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLA 191
Query: 113 YAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTAS 172
+P G D ++ D E +++ H + ++A F + I T S
Sbjct: 192 VSPDFNLFISGACDASAKLW----DVREGTC--RQTFTGHESDINAICFFPNGEAICTGS 245
Query: 173 GDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCV 232
D +C L+D+ + Q L F +A S +G +G D VWD + V
Sbjct: 246 DDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERV 305
Query: 233 QAFETHESDINSVRYYPSGDAFASGSDDATCRLYD 267
H++ ++ + G A A+GS D+ ++++
Sbjct: 306 GILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 125 bits (313), Expect = 7e-29
Identities = 79/296 (26%), Positives = 131/296 (44%), Gaps = 10/296 (3%)
Query: 57 RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 116
R KGH + V C+D+ + +++ S S D ++VW ++ + T V ++PS
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
Query: 117 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT 176
G +A G D ++ N+ + HT + + F + +TAS D T
Sbjct: 73 GHLLASGSRDKTVRIWV------PNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
Query: 177 CALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFE 236
+W + L S H V C +P G VS DK +WD S +CV ++
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPD--GRLIVSASDDKTVKLWDKSSRECVHSYC 184
Query: 237 THESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGR 296
H + V ++PSG A+ D T +++D+R R + Y S + + F SG
Sbjct: 185 EHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSA--AVNGLSFHPSGN 242
Query: 297 LLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
L +D T+ + D+++G + L GH+ +T+ S G F SG D + VW
Sbjct: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 49.7 bits (117), Expect = 4e-06
Identities = 31/121 (25%), Positives = 58/121 (47%), Gaps = 6/121 (4%)
Query: 235 FETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYS--KESIIFGASSVDFS 292
F+ H + V + + ASGS D+ ++ ++ ++ K+++ + V+FS
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAV----TCVNFS 70
Query: 293 LSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
SG LL +G D T+ +W ++ H V ++ DG +F + S D T++VW
Sbjct: 71 PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130
Query: 353 A 353
A
Sbjct: 131 A 131
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 125 bits (313), Expect = 7e-29
Identities = 79/296 (26%), Positives = 131/296 (44%), Gaps = 10/296 (3%)
Query: 57 RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 116
R KGH + V C+D+ + +++ S S D ++VW ++ + T V ++PS
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
Query: 117 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT 176
G +A G D ++ N+ + HT + + F + +TAS D T
Sbjct: 73 GHLLASGSRDKTVRIWV------PNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
Query: 177 CALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFE 236
+W + L S H V C +P G VS DK +WD S +CV ++
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPD--GRLIVSASDDKTVKLWDKSSRECVHSYC 184
Query: 237 THESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGR 296
H + V ++PSG A+ D T +++D+R R + Y S + + F SG
Sbjct: 185 EHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSA--AVNGLSFHPSGN 242
Query: 297 LLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
L +D T+ + D+++G + L GH+ +T+ S G F SG D + VW
Sbjct: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 49.7 bits (117), Expect = 4e-06
Identities = 31/121 (25%), Positives = 58/121 (47%), Gaps = 6/121 (4%)
Query: 235 FETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYS--KESIIFGASSVDFS 292
F+ H + V + + ASGS D+ ++ ++ ++ K+++ + V+FS
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAV----TCVNFS 70
Query: 293 LSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
SG LL +G D T+ +W ++ H V ++ DG +F + S D T++VW
Sbjct: 71 PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130
Query: 353 A 353
A
Sbjct: 131 A 131
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 117 bits (293), Expect = 2e-26
Identities = 72/214 (33%), Positives = 112/214 (52%), Gaps = 4/214 (1%)
Query: 139 NENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADV 198
+E A++ K + H+ + SF+ +L++S DGT LW +++ L + GH V
Sbjct: 529 DEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPV 588
Query: 199 LCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGS 258
+P G FVSGG D+ A +W Q ++ F H +D+N R++P+ + A+GS
Sbjct: 589 WDTQFSPY--GYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGS 646
Query: 259 DDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRV 318
D T RL+D+ V I++ S+ FS +GR L G D + +WD+ G V
Sbjct: 647 ADRTVRLWDVLNGNCVRIFTGHK--GPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMV 704
Query: 319 SILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
L GH + V +LR S DG SGS D+T+R+W
Sbjct: 705 GELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
Score = 82.0 bits (201), Expect = 7e-16
Identities = 65/250 (26%), Positives = 108/250 (43%), Gaps = 14/250 (5%)
Query: 20 ESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIV 79
+ L+ + L D E V ER+ + + + L GH V + D+ ++
Sbjct: 502 KKLRSVKQASDLSLIDKESDDVLERI--MDEKTASELKILYGHSGPVYGASFSPDRNYLL 559
Query: 80 SSSQDGKVIVWD--SFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFD 137
SSS+DG V +W +FT + W ++P G GG D ++ D
Sbjct: 560 SSSEDGTVRLWSLQTFTCLVGYKGHNYPVW--DTQFSPYGYYFVSGGHDRVARLWAT--D 615
Query: 138 KNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGAD 197
+ + + A H ++ F + + T S D T LWDV +G ++ F GH
Sbjct: 616 HYQPL----RIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGP 671
Query: 198 VLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASG 257
+ L +P+ G +G D + ++WD+ G V + H + S+R+ G+ ASG
Sbjct: 672 IHSLTFSPN--GRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASG 729
Query: 258 SDDATCRLYD 267
S D T RL+D
Sbjct: 730 SMDNTVRLWD 739
Score = 45.8 bits (107), Expect = 6e-05
Identities = 47/237 (19%), Positives = 82/237 (34%), Gaps = 53/237 (22%)
Query: 156 LSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSG 215
L+A T+ I D T +W V +L +D+ +D
Sbjct: 473 LTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSV--KQASDLSLIDKESD--------- 521
Query: 216 GCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRA----- 270
D + D ++ ++ H + + P + S S+D T RL+ L+
Sbjct: 522 --DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLV 579
Query: 271 --------------------------DREVAIYSKESI----IFGASSVD-----FSLSG 295
DR +++ + IF D F +
Sbjct: 580 GYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNS 639
Query: 296 RLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
+ G D T+ +WDVL G+ V I GH+ + +L SP+G +G+ D + +W
Sbjct: 640 NYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLW 696
Score = 42.4 bits (98), Expect = 6e-04
Identities = 33/123 (26%), Positives = 50/123 (40%), Gaps = 4/123 (3%)
Query: 232 VQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAI-YSKESIIFGASSVD 290
V+ + + SV+ SDD R+ D + E+ I Y ++GAS
Sbjct: 494 VRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGAS--- 550
Query: 291 FSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLR 350
FS L + D T+ +W + + + GH V + SP G F SG D R
Sbjct: 551 FSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVAR 610
Query: 351 VWA 353
+WA
Sbjct: 611 LWA 613
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 109 bits (272), Expect = 4e-24
Identities = 69/239 (28%), Positives = 111/239 (46%), Gaps = 11/239 (4%)
Query: 116 SGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNS-DMQILTASGD 174
SG G D C ++ + N ++ H N + A +F N +I T S D
Sbjct: 103 SGSCFITGSYDRTCKLWDTASGEELN------TLEGHRNVVYAIAFNNPYGDKIATGSFD 156
Query: 175 GTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQA 234
TC LW VE+G+ +F GH A+++CL P T +G D A +WD+++G+ V
Sbjct: 157 KTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQST--LVATGSMDTTAKLWDIQNGEEVYT 214
Query: 235 FETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLS 294
H ++I S+ + SGD +GS D T ++D R+V I ++S ++ S
Sbjct: 215 LRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS 274
Query: 295 GRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 353
L+ G D T +WD G V+ L GH++ + G + S D T R+++
Sbjct: 275 --LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFS 331
Score = 107 bits (267), Expect = 2e-23
Identities = 62/206 (30%), Positives = 100/206 (48%), Gaps = 3/206 (1%)
Query: 147 KSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPS 206
K + H L+ + S +T S D TC LWD SG+ L + GH V + +
Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN-N 144
Query: 207 ETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLY 266
G+ +G DK +W + +G+C F H ++I + + P A+GS D T +L+
Sbjct: 145 PYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLW 204
Query: 267 DLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHEN 326
D++ EV Y+ S+ F+ SG + G D+T+ VWD G +V+IL GH
Sbjct: 205 DIQNGEEV--YTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCA 262
Query: 327 RVSTLRVSPDGTAFCSGSWDHTLRVW 352
+S+ + D + +GS D T ++W
Sbjct: 263 EISSASFNWDCSLILTGSMDKTCKLW 288
Score = 102 bits (255), Expect = 4e-22
Identities = 70/297 (23%), Positives = 130/297 (43%), Gaps = 13/297 (4%)
Query: 58 TLKGHGNKVLCMDWCKDKR-RIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 116
TL+GH N V + + +I + S D +W T H ++ ++ P
Sbjct: 129 TLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQ 188
Query: 117 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT 176
+A G +D ++ + + ++ H+ + + SF S +I+T S D T
Sbjct: 189 STLVATGSMDTTAKLWDI------QNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHT 242
Query: 177 CALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFE 236
+WD ++G+ + GH A++ + + ++G DK +WD +G+CV
Sbjct: 243 VVVWDADTGRKVNILIGHCAEISSASF--NWDCSLILTGSMDKTCKLWDATNGKCVATLT 300
Query: 237 THESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVA-IYSKESIIFGASSVDFSLSG 295
H+ +I + +G A+ S D T R++ + +A + E I S + F+ G
Sbjct: 301 GHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEI---SKISFNPQG 357
Query: 296 RLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
L G +D T +WD G + +L GH + + + + G +GS D+T R+W
Sbjct: 358 NHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 98.6 bits (244), Expect = 7e-21
Identities = 61/259 (23%), Positives = 113/259 (43%), Gaps = 14/259 (5%)
Query: 54 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAY 113
K T +GH +++C+ + + + S D +WD + + + +++ ++
Sbjct: 168 KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSF 227
Query: 114 APSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASG 173
SG I G D+ V+ + N+ + H +S+ SF ILT S
Sbjct: 228 NTSGDRIITGSFDHTVVVWDADTGRKVNI------LIGHCAEISSASFNWDCSLILTGSM 281
Query: 174 DGTCALWDVESGQLLQSFHGHGADVL--CLDLAPSETGNTFVSGGCDKKAMVWDMRSGQC 231
D TC LWD +G+ + + GH ++L C D TG + D A ++ + +C
Sbjct: 282 DKTCKLWDATNGKCVATLTGHDDEILDSCFDY----TGKLIATASADGTARIFSAATRKC 337
Query: 232 VQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDF 291
+ E HE +I+ + + P G+ +GS D T R++D + + + + E S F
Sbjct: 338 IAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVL--EGHTDEIFSCAF 395
Query: 292 SLSGRLLFAGYNDYTINVW 310
+ G ++ G D T +W
Sbjct: 396 NYKGNIVITGSKDNTCRIW 414
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 106 bits (264), Expect = 4e-23
Identities = 70/269 (26%), Positives = 115/269 (42%), Gaps = 10/269 (3%)
Query: 84 DGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMA 143
D ++VW ++ + T V ++PSG +A G D ++ N+
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWV------PNVK 55
Query: 144 AKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDL 203
+ HT + + F + +TAS D T +W + L S H V C
Sbjct: 56 GESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKF 115
Query: 204 APSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATC 263
+P G VS DK +WD S +CV ++ H + V ++PSG A+ D T
Sbjct: 116 SPD--GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTV 173
Query: 264 RLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFG 323
+++D+R R + Y S + + F SG L +D T+ + D+++G + L G
Sbjct: 174 KVWDVRTHRLLQHYQLHSA--AVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHG 231
Query: 324 HENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
H+ +T+ S G F SG D + VW
Sbjct: 232 HQGPATTVAFSRTGEYFASGGSDEQVMVW 260
Score = 98.2 bits (243), Expect = 1e-20
Identities = 63/250 (25%), Positives = 111/250 (44%), Gaps = 10/250 (4%)
Query: 61 GHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAI 120
GH + V C+++ + S S+D V +W + V + + G +
Sbjct: 21 GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSF 80
Query: 121 ACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALW 180
D V+ K S++ H N++ F+ I++AS D T LW
Sbjct: 81 VTASDDKTVKVWATHRQKF------LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 134
Query: 181 DVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHES 240
D S + + S+ HG V +D PS G + G D VWD+R+ + +Q ++ H +
Sbjct: 135 DKSSRECVHSYCEHGGFVTYVDFHPS--GTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSA 192
Query: 241 DINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFA 300
+N + ++PSG+ + S D+T ++ DL R +Y+ A++V FS +G +
Sbjct: 193 AVNGLSFHPSGNYLITASSDSTLKILDLMEGR--LLYTLHGHQGPATTVAFSRTGEYFAS 250
Query: 301 GYNDYTINVW 310
G +D + VW
Sbjct: 251 GGSDEQVMVW 260
Score = 83.6 bits (205), Expect = 2e-16
Identities = 54/167 (32%), Positives = 80/167 (47%), Gaps = 8/167 (4%)
Query: 58 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 117
+L H N V C + D R IVS+S D V +WD + H+ +V + PSG
Sbjct: 102 SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG 161
Query: 118 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 177
IA G+DN V+ + + + +H+ ++ SF S ++TAS D T
Sbjct: 162 TCIAAAGMDNTVKVWDVRTHR------LLQHYQLHSAAVNGLSFHPSGNYLITASSDSTL 215
Query: 178 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVW 224
+ D+ G+LL + HGH +A S TG F SGG D++ MVW
Sbjct: 216 KILDLMEGRLLYTLHGHQGP--ATTVAFSRTGEYFASGGSDEQVMVW 260
Score = 43.9 bits (102), Expect = 2e-04
Identities = 22/65 (33%), Positives = 34/65 (52%)
Query: 289 VDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHT 348
V+FS SG LL +G D T+ +W ++ H V ++ DG +F + S D T
Sbjct: 29 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 88
Query: 349 LRVWA 353
++VWA
Sbjct: 89 VKVWA 93
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 105 bits (261), Expect = 8e-23
Identities = 74/296 (25%), Positives = 126/296 (42%), Gaps = 10/296 (3%)
Query: 57 RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 116
R KGH + +D + +++ ++S D +++W+ + + V + ++P
Sbjct: 12 RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
Query: 117 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT 176
G +A D ++ + K HT + + F+ + TAS D +
Sbjct: 72 GNLLASASRDRTVRLWI------PDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKS 125
Query: 177 CALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFE 236
+W + + L S + H V C +P G VS DK +WD + QCV F
Sbjct: 126 IKVWSMYRQRFLYSLYRHTHWVRCAKFSPD--GRLIVSCSEDKTIKIWDTTNKQCVNNFS 183
Query: 237 THESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGR 296
N V + PSG AS D T +++D+R ++ + Y S G + + F SG
Sbjct: 184 DSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHS--GGVNCISFHPSGN 241
Query: 297 LLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
L +D T+ + D+L+G + L GH V T+ S G F SG D + +W
Sbjct: 242 YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 78.2 bits (191), Expect = 1e-14
Identities = 50/170 (29%), Positives = 79/170 (46%), Gaps = 4/170 (2%)
Query: 183 ESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDI 242
E L + F GH A + LDL+P+ G + D M+W+ + + H+ +
Sbjct: 6 EDPVLERYFKGHKAAITSLDLSPN--GKQLATASWDTFLMLWNFKPHARAYRYVGHKDVV 63
Query: 243 NSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGY 302
SV++ P G+ AS S D T RL+ D+ ++ SVDFS G+ L
Sbjct: 64 TSVQFSPHGNLLASASRDRTVRLWI--PDKRGKFSEFKAHTAPVRSVDFSADGQFLATAS 121
Query: 303 NDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
D +I VW + + + L+ H + V + SPDG S S D T+++W
Sbjct: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW 171
Score = 48.9 bits (115), Expect = 7e-06
Identities = 32/119 (26%), Positives = 54/119 (45%), Gaps = 2/119 (1%)
Query: 235 FETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLS 294
F+ H++ I S+ P+G A+ S D L++ + Y + +SV FS
Sbjct: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDV--VTSVQFSPH 71
Query: 295 GRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 353
G LL + D T+ +W K + S H V ++ S DG + S D +++VW+
Sbjct: 72 GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWS 130
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 104 bits (260), Expect = 1e-22
Identities = 64/248 (25%), Positives = 117/248 (47%), Gaps = 12/248 (4%)
Query: 108 VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQ 167
V + ++P+G +A D ++ K E K+++ H +S ++++
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE------KTISGHKLGISDVAWSSDSNL 101
Query: 168 ILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMR 227
+++AS D T +WDV SG+ L++ GH V C + P N VSG D+ +WD++
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS--NLIVSGSFDESVRIWDVK 159
Query: 228 SGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGAS 287
+G+C++ H +++V + G S S D CR++D + + + + S
Sbjct: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP-PVS 218
Query: 288 SVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVS---PDGTAFCSGS 344
V FS +G+ + A D T+ +WD KG + GH+N + + G SGS
Sbjct: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 278
Query: 345 WDHTLRVW 352
D+ + +W
Sbjct: 279 EDNLVYIW 286
Score = 93.2 bits (230), Expect = 3e-19
Identities = 55/210 (26%), Positives = 102/210 (48%), Gaps = 5/210 (2%)
Query: 144 AKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDL 203
A K ++A HT +S+ F+ + + ++S D +W G+ ++ GH + D+
Sbjct: 36 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGI--SDV 93
Query: 204 APSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATC 263
A S N VS DK +WD+ SG+C++ + H + + + P + SGS D +
Sbjct: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153
Query: 264 RLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFG 323
R++D++ + + S S+V F+ G L+ + D +WD G + L
Sbjct: 154 RIWDVKTGKCLKTLPAHS--DPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211
Query: 324 HEN-RVSTLRVSPDGTAFCSGSWDHTLRVW 352
+N VS ++ SP+G + + D+TL++W
Sbjct: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLW 241
Score = 89.4 bits (220), Expect = 5e-18
Identities = 66/302 (21%), Positives = 132/302 (43%), Gaps = 18/302 (5%)
Query: 58 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 117
TL GH V + + + + SSS D + +W ++ E ++ + A++
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 118 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 177
+ D ++ ++ K K++ H+NY+ C+F I++ S D +
Sbjct: 100 NLLVSASDDKTLKIWDVSSGK------CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153
Query: 178 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQA-FE 236
+WDV++G+ L++ H V + + G+ VS D +WD SGQC++ +
Sbjct: 154 RIWDVKTGKCLKTLPAHSDPVSAVHF--NRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211
Query: 237 THESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIY----SKESIIFGASSVDFS 292
++ V++ P+G + + D T +L+D + + Y +++ IF SV
Sbjct: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV--- 268
Query: 293 LSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSW--DHTLR 350
G+ + +G D + +W++ V L GH + V + P S + D T++
Sbjct: 269 TGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIK 328
Query: 351 VW 352
+W
Sbjct: 329 LW 330
Score = 79.7 bits (195), Expect = 4e-15
Identities = 58/216 (26%), Positives = 94/216 (43%), Gaps = 8/216 (3%)
Query: 54 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAY 113
K +TLKGH N V C ++ IVS S D V +WD T + V A +
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF 179
Query: 114 APSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASG 173
G I D C ++ + K + +S F+ + IL A+
Sbjct: 180 NRDGSLIVSSSYDGLCRIWDTASGQ-----CLKTLIDDDNPPVSFVKFSPNGKYILAATL 234
Query: 174 DGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTF-VSGGCDKKAMVWDMRSGQCV 232
D T LWD G+ L+++ GH + C+ S TG + VSG D +W++++ + V
Sbjct: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 294
Query: 233 QAFETHESDINSVRYYPSGDAFASGS--DDATCRLY 266
Q + H + S +P+ + AS + +D T +L+
Sbjct: 295 QKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 77.8 bits (190), Expect = 1e-14
Identities = 59/270 (21%), Positives = 115/270 (42%), Gaps = 12/270 (4%)
Query: 45 VEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMP 104
++ G + K +T+ GH + + W D +VS+S D + +WD + +
Sbjct: 69 IKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGH 128
Query: 105 CTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNS 164
+V C + P I G D ++ + K K++ H++ +SA F
Sbjct: 129 SNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK------CLKTLPAHSDPVSAVHFNRD 182
Query: 165 DMQILTASGDGTCALWDVESGQLLQS-FHGHGADVLCLDLAPSETGNTFVSGGCDKKAMV 223
I+++S DG C +WD SGQ L++ V + +P+ G ++ D +
Sbjct: 183 GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPN--GKYILAATLDNTLKL 240
Query: 224 WDMRSGQCVQAFETHESD---INSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKE 280
WD G+C++ + H+++ I + G SGS+D +++L+ V
Sbjct: 241 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 300
Query: 281 SIIFGASSVDFSLSGRLLFAGYNDYTINVW 310
+ + +++ + + A ND TI +W
Sbjct: 301 TDVVISTACHPTENIIASAALENDKTIKLW 330
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 104 bits (260), Expect = 1e-22
Identities = 64/248 (25%), Positives = 117/248 (47%), Gaps = 12/248 (4%)
Query: 108 VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQ 167
V + ++P+G +A D ++ K E K+++ H +S ++++
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE------KTISGHKLGISDVAWSSDSNL 101
Query: 168 ILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMR 227
+++AS D T +WDV SG+ L++ GH V C + P N VSG D+ +WD++
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS--NLIVSGSFDESVRIWDVK 159
Query: 228 SGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGAS 287
+G+C++ H +++V + G S S D CR++D + + + + S
Sbjct: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP-PVS 218
Query: 288 SVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVS---PDGTAFCSGS 344
V FS +G+ + A D T+ +WD KG + GH+N + + G SGS
Sbjct: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 278
Query: 345 WDHTLRVW 352
D+ + +W
Sbjct: 279 EDNLVYIW 286
Score = 93.2 bits (230), Expect = 3e-19
Identities = 55/210 (26%), Positives = 102/210 (48%), Gaps = 5/210 (2%)
Query: 144 AKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDL 203
A K ++A HT +S+ F+ + + ++S D +W G+ ++ GH + D+
Sbjct: 36 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGI--SDV 93
Query: 204 APSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATC 263
A S N VS DK +WD+ SG+C++ + H + + + P + SGS D +
Sbjct: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153
Query: 264 RLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFG 323
R++D++ + + S S+V F+ G L+ + D +WD G + L
Sbjct: 154 RIWDVKTGKCLKTLPAHS--DPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211
Query: 324 HEN-RVSTLRVSPDGTAFCSGSWDHTLRVW 352
+N VS ++ SP+G + + D+TL++W
Sbjct: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLW 241
Score = 89.4 bits (220), Expect = 5e-18
Identities = 66/302 (21%), Positives = 132/302 (43%), Gaps = 18/302 (5%)
Query: 58 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 117
TL GH V + + + + SSS D + +W ++ E ++ + A++
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 118 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 177
+ D ++ ++ K K++ H+NY+ C+F I++ S D +
Sbjct: 100 NLLVSASDDKTLKIWDVSSGK------CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153
Query: 178 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQA-FE 236
+WDV++G+ L++ H V + + G+ VS D +WD SGQC++ +
Sbjct: 154 RIWDVKTGKCLKTLPAHSDPVSAVHF--NRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211
Query: 237 THESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIY----SKESIIFGASSVDFS 292
++ V++ P+G + + D T +L+D + + Y +++ IF SV
Sbjct: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV--- 268
Query: 293 LSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSW--DHTLR 350
G+ + +G D + +W++ V L GH + V + P S + D T++
Sbjct: 269 TGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIK 328
Query: 351 VW 352
+W
Sbjct: 329 LW 330
Score = 79.7 bits (195), Expect = 4e-15
Identities = 58/216 (26%), Positives = 94/216 (43%), Gaps = 8/216 (3%)
Query: 54 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAY 113
K +TLKGH N V C ++ IVS S D V +WD T + V A +
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF 179
Query: 114 APSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASG 173
G I D C ++ + K + +S F+ + IL A+
Sbjct: 180 NRDGSLIVSSSYDGLCRIWDTASGQ-----CLKTLIDDDNPPVSFVKFSPNGKYILAATL 234
Query: 174 DGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTF-VSGGCDKKAMVWDMRSGQCV 232
D T LWD G+ L+++ GH + C+ S TG + VSG D +W++++ + V
Sbjct: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 294
Query: 233 QAFETHESDINSVRYYPSGDAFASGS--DDATCRLY 266
Q + H + S +P+ + AS + +D T +L+
Sbjct: 295 QKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 77.8 bits (190), Expect = 1e-14
Identities = 59/270 (21%), Positives = 115/270 (42%), Gaps = 12/270 (4%)
Query: 45 VEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMP 104
++ G + K +T+ GH + + W D +VS+S D + +WD + +
Sbjct: 69 IKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGH 128
Query: 105 CTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNS 164
+V C + P I G D ++ + K K++ H++ +SA F
Sbjct: 129 SNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK------CLKTLPAHSDPVSAVHFNRD 182
Query: 165 DMQILTASGDGTCALWDVESGQLLQS-FHGHGADVLCLDLAPSETGNTFVSGGCDKKAMV 223
I+++S DG C +WD SGQ L++ V + +P+ G ++ D +
Sbjct: 183 GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPN--GKYILAATLDNTLKL 240
Query: 224 WDMRSGQCVQAFETHESD---INSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKE 280
WD G+C++ + H+++ I + G SGS+D +++L+ V
Sbjct: 241 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 300
Query: 281 SIIFGASSVDFSLSGRLLFAGYNDYTINVW 310
+ + +++ + + A ND TI +W
Sbjct: 301 TDVVISTACHPTENIIASAALENDKTIKLW 330
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 103 bits (257), Expect = 2e-22
Identities = 77/318 (24%), Positives = 143/318 (44%), Gaps = 37/318 (11%)
Query: 59 LKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVW---DSFTTNKEHAVTMPCTW-------- 107
L+GH ++V W + S S D +W ++ T+ V C
Sbjct: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS 224
Query: 108 ---VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNS 164
V + + G +A G D ++ K+ N+A+ ++ H + A +
Sbjct: 225 NKDVTSLDWNSEGTLLATGSYDGFARIWT----KDGNLAS---TLGQHKGPIFALKWNKK 277
Query: 165 DMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVW 224
IL+A D T +WD +G+ Q F H A L +D ++ NTF S D V
Sbjct: 278 GNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW---QSNNTFASCSTDMCIHVC 334
Query: 225 DMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRAD---REVAIYSKES 281
+ + ++ F+ H +++N++++ P+G+ AS SDD T +++ ++ D ++ ++KE
Sbjct: 335 KLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEI 394
Query: 282 IIF-------GASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVS 334
G ++ + +L +L + D T+ +WDV +G + L H+ V ++ S
Sbjct: 395 YTIKWSPTGPGTNNPNANL---MLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFS 451
Query: 335 PDGTAFCSGSWDHTLRVW 352
PDG SGS+D + +W
Sbjct: 452 PDGRYLASGSFDKCVHIW 469
Score = 69.3 bits (168), Expect = 5e-12
Identities = 56/264 (21%), Positives = 102/264 (38%), Gaps = 17/264 (6%)
Query: 58 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 117
TL H + + W K I+S+ D I+WD+ T + + + +
Sbjct: 261 TLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNN 320
Query: 118 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 177
+C D V L D+ K+ HTN ++A + + + + S D T
Sbjct: 321 TFASCS-TDMCIHVCKLGQDR------PIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTL 373
Query: 178 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNT-------FVSGGCDKKAMVWDMRSGQ 230
+W ++ + H ++ + +P+ G S D +WD+ G
Sbjct: 374 KIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGI 433
Query: 231 CVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVD 290
C+ H+ + SV + P G ASGS D +++ + V Y IF V
Sbjct: 434 CIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIF---EVC 490
Query: 291 FSLSGRLLFAGYNDYTINVWDVLK 314
++ +G + A +D ++ V D+ K
Sbjct: 491 WNAAGDKVGASASDGSVCVLDLRK 514
Score = 56.2 bits (134), Expect = 4e-08
Identities = 53/258 (20%), Positives = 91/258 (35%), Gaps = 64/258 (24%)
Query: 108 VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMH------------TNY 155
V CA+ P +A G D+ ++ L+ EN + + +
Sbjct: 172 VFICAWNPVSDLLASGSGDSTARIWNLS----ENSTSGSTQLVLRHCIREGGQDVPSNKD 227
Query: 156 LSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSG 215
+++ + + + T S DG +W + G L + H + L ++ GN +S
Sbjct: 228 VTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKW--NKKGNFILSA 284
Query: 216 GCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVA 275
G DK ++WD +G+ Q F H + V + S + FAS S D + L DR +
Sbjct: 285 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-SNNTFASCSTDMCIHVCKLGQDRPIK 343
Query: 276 IYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSP 335
+ GH N V+ ++ P
Sbjct: 344 TFQ--------------------------------------------GHTNEVNAIKWDP 359
Query: 336 DGTAFCSGSWDHTLRVWA 353
G S S D TL++W+
Sbjct: 360 TGNLLASCSDDMTLKIWS 377
Score = 52.4 bits (124), Expect = 6e-07
Identities = 45/213 (21%), Positives = 80/213 (37%), Gaps = 42/213 (19%)
Query: 57 RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 116
+T +GH N+V + W + S S D + +W N H + + ++P+
Sbjct: 343 KTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPT 402
Query: 117 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT 176
G G +N N+++ + +AS D T
Sbjct: 403 G-----PGTNN----------------------------------PNANLMLASASFDST 423
Query: 177 CALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFE 236
LWDV+ G + + H V + +P G SG DK +W+ ++G V ++
Sbjct: 424 VRLWDVDRGICIHTLTKHQEPVYSVAFSPD--GRYLASGSFDKCVHIWNTQTGALVHSYR 481
Query: 237 THESDINSVRYYPSGDAFASGSDDATCRLYDLR 269
I V + +GD + + D + + DLR
Sbjct: 482 -GTGGIFEVCWNAAGDKVGASASDGSVCVLDLR 513
Score = 29.3 bits (64), Expect = 5.6
Identities = 13/37 (35%), Positives = 19/37 (51%)
Query: 316 SRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
++ +L GHE+ V +P SGS D T R+W
Sbjct: 160 NKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIW 196
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 103 bits (257), Expect = 2e-22
Identities = 63/248 (25%), Positives = 118/248 (47%), Gaps = 12/248 (4%)
Query: 108 VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQ 167
V + ++P+G +A D ++ K E K++ H +S ++++ +
Sbjct: 44 VSSVKFSPNGEWLASSSADRLIIIWGAYDGKYE------KTLYGHNLEISDVAWSSDSSR 97
Query: 168 ILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMR 227
+++AS D T LWDV SG+ L++ GH V C + P N +SG D+ +W+++
Sbjct: 98 LVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPS--NLIISGSFDETVKIWEVK 155
Query: 228 SGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGAS 287
+G+C++ H +++V + SG SGS D CR++D + + + + S
Sbjct: 156 TGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNP-PVS 214
Query: 288 SVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVS---PDGTAFCSGS 344
V FS +G+ + D T+ +WD +G + GH+N + + G SGS
Sbjct: 215 FVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 274
Query: 345 WDHTLRVW 352
D+ + +W
Sbjct: 275 EDNLVYIW 282
Score = 98.6 bits (244), Expect = 7e-21
Identities = 59/216 (27%), Positives = 109/216 (50%), Gaps = 6/216 (2%)
Query: 138 KNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGAD 197
+N N A K V HT +S+ F+ + + ++S D +W G+ ++ +GH +
Sbjct: 27 ENPNYALKCTLVG-HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLE 85
Query: 198 VLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASG 257
+ D+A S + VS DK +WD+RSG+C++ + H + + + P + SG
Sbjct: 86 I--SDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISG 143
Query: 258 SDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSR 317
S D T ++++++ + + S S S+V F+ SG L+ +G D +WD G
Sbjct: 144 SFDETVKIWEVKTGKCLKTLSAHS--DPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQC 201
Query: 318 VSILFGHEN-RVSTLRVSPDGTAFCSGSWDHTLRVW 352
+ L +N VS ++ SP+G + + D+TL++W
Sbjct: 202 LKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLW 237
Score = 80.1 bits (196), Expect = 3e-15
Identities = 62/266 (23%), Positives = 116/266 (43%), Gaps = 12/266 (4%)
Query: 49 GQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWV 108
G + K +TL GH ++ + W D R+VS+S D + +WD + + +V
Sbjct: 69 GAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYV 128
Query: 109 MACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQI 168
C + P I G D ++ + K K+++ H++ +SA F S I
Sbjct: 129 FCCNFNPPSNLIISGSFDETVKIWEVKTGK------CLKTLSAHSDPVSAVHFNCSGSLI 182
Query: 169 LTASGDGTCALWDVESGQLLQSF-HGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMR 227
++ S DG C +WD SGQ L++ V + +P+ G ++ D +WD
Sbjct: 183 VSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPN--GKYILTATLDNTLKLWDYS 240
Query: 228 SGQCVQAFETHESD---INSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIF 284
G+C++ + H+++ I + G SGS+D +++L+ V + +
Sbjct: 241 RGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 300
Query: 285 GASSVDFSLSGRLLFAGYNDYTINVW 310
+++ + + A ND TI +W
Sbjct: 301 ISAACHPTENLIASAALENDKTIKLW 326
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 103 bits (256), Expect = 3e-22
Identities = 69/237 (29%), Positives = 117/237 (49%), Gaps = 11/237 (4%)
Query: 116 SGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDG 175
SG +A GG D + +++ + N S+ HT+ + + + I+ S G
Sbjct: 32 SGRLLATGGDDCRVNLWSI------NKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSG 85
Query: 176 TCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAF 235
+ +WD+E+ ++L++ GH A++ LD P G SG D +WD+R CV +
Sbjct: 86 SIRVWDLEAAKILRTLMGHKANICSLDFHPY--GEFVASGSQDTNIKLWDIRRKGCVFRY 143
Query: 236 ETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSG 295
H + +R+ P G AS +DD T +L+DL A + ++ + + + V+F +
Sbjct: 144 RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHT--GPVNVVEFHPNE 201
Query: 296 RLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
LL +G +D TI WD+ K VS + G V ++ +PDG SG D +LRV+
Sbjct: 202 YLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVY 257
Score = 91.7 bits (226), Expect = 9e-19
Identities = 55/211 (26%), Positives = 99/211 (46%), Gaps = 5/211 (2%)
Query: 143 AAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCA-LWDVESGQLLQSFHGHGADVLCL 201
A K + + H + +S+ + ++L GD LW + + S GH + V +
Sbjct: 10 AWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESV 69
Query: 202 DLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDA 261
L E V+G VWD+ + + ++ H+++I S+ ++P G+ ASGS D
Sbjct: 70 RLNTPE--ELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDT 127
Query: 262 TCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSIL 321
+L+D+R R+ ++ + FS G+ L + +D+T+ +WD+ G +S
Sbjct: 128 NIKLWDIR--RKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEF 185
Query: 322 FGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
GH V+ + P+ SGS D T+R W
Sbjct: 186 PGHTGPVNVVEFHPNEYLLASGSSDRTIRFW 216
Score = 69.3 bits (168), Expect = 5e-12
Identities = 50/215 (23%), Positives = 89/215 (41%), Gaps = 9/215 (4%)
Query: 58 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 117
+L GH + V + + IV+ SQ G + VWD + + + + P G
Sbjct: 58 SLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYG 117
Query: 118 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 177
+A G D ++ + + + + + H+ + F+ + +A+ D T
Sbjct: 118 EFVASGSQDTNIKLWDI---RRKGCVFRYRG---HSQAVRCLRFSPDGKWLASAADDHTV 171
Query: 178 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFET 237
LWD+ +G+++ F GH V ++ P+E SG D+ WD+ Q V E
Sbjct: 172 KLWDLTAGKMMSEFPGHTGPVNVVEFHPNE--YLLASGSSDRTIRFWDLEKFQVVSCIEG 229
Query: 238 HESDINSVRYYPSGDAFASGSDDATCRLYDLRADR 272
+ SV + P G SG D + R+Y +R
Sbjct: 230 EPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPER 263
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 103 bits (256), Expect = 3e-22
Identities = 69/225 (30%), Positives = 112/225 (49%), Gaps = 11/225 (4%)
Query: 130 SVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQ 189
SV + D +E +A + HT ++ + S + T D + LWD+E+ + +
Sbjct: 304 SVKLWSLDSDEPVA----DIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEIL 359
Query: 190 SFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYP 249
GH V D+A + G+ +GG D VWD+R+G+C+ E H +I + + P
Sbjct: 360 HQEGHSMGVY--DIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSP 417
Query: 250 SGDAFASGSDDATCRLYDLRADREV-AIYSKESIIFGASSVDFS-LSGRLLFAGYNDYTI 307
+G A+GS D TC+++DLR R V I + ++++ G V F + G L G D T
Sbjct: 418 NGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTG---VKFEPIHGNFLLTGAYDNTA 474
Query: 308 NVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
+W S + L GHE +V L +S DG + S+D T ++W
Sbjct: 475 KIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 92.0 bits (227), Expect = 7e-19
Identities = 59/203 (29%), Positives = 86/203 (42%), Gaps = 8/203 (3%)
Query: 156 LSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGN----- 210
+S C F+ + + TA G C LW V LL + GH +V + P T +
Sbjct: 234 ISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKD 293
Query: 211 -TFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLR 269
S D +W + S + V E H + V ++PSG + D + RL+DL
Sbjct: 294 VNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLE 353
Query: 270 ADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVS 329
A E I +E G + F G L G D VWD+ G + L GH +
Sbjct: 354 AQEE--ILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIY 411
Query: 330 TLRVSPDGTAFCSGSWDHTLRVW 352
+ SP+G +GS D+T +VW
Sbjct: 412 GINFSPNGYHIATGSGDNTCKVW 434
Score = 42.4 bits (98), Expect = 6e-04
Identities = 31/119 (26%), Positives = 49/119 (41%), Gaps = 21/119 (17%)
Query: 113 YAPSGCAIACGGLDNKCSVYPL-------TFDKNENMAAKKKSVAMHTNYLSACSFTNSD 165
++P+G IA G DN C V+ L T ++N+ K +H N+L
Sbjct: 415 FSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFL--------- 465
Query: 166 MQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVW 224
LT + D T +W L++ GH V+ LD+ S G + D+ +W
Sbjct: 466 ---LTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDI--SSDGQLIATCSYDRTFKLW 519
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 100 bits (249), Expect = 2e-21
Identities = 82/349 (23%), Positives = 148/349 (42%), Gaps = 37/349 (10%)
Query: 27 EEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGK 86
EE RA H V H ++ + L+GH ++V W + S S D
Sbjct: 147 EENRA--HSVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDST 204
Query: 87 VIVW---DSFTTNKEHAVTMPCTW-----------VMACAYAPSGCAIACGGLDNKCSVY 132
+W ++ V C V + + +G +A G D ++
Sbjct: 205 ARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW 264
Query: 133 PLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFH 192
++ N+A+ ++ H + A + IL+A D T +WD +G+ Q F
Sbjct: 265 ----TEDGNLAS---TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFP 317
Query: 193 GHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGD 252
H A L +D + TF S D V + + V+ F+ H +++N++++ PSG
Sbjct: 318 FHSAPALDVDW---QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGM 374
Query: 253 AFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGR---------LLFAGYN 303
AS SDD T +++ ++ +EV I+ ++ ++ +S +G +L +
Sbjct: 375 LLASCSDDMTLKIWSMK--QEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASF 432
Query: 304 DYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
D T+ +WD+ +G L H+ V ++ SPDG SGS+D + +W
Sbjct: 433 DSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIW 481
Score = 69.3 bits (168), Expect = 5e-12
Identities = 56/264 (21%), Positives = 102/264 (38%), Gaps = 17/264 (6%)
Query: 58 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 117
TL H + + W + I+S+ D I+WD+ T + + + +
Sbjct: 273 TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNT 332
Query: 118 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 177
+C D V L D+ K+ HTN ++A + S M + + S D T
Sbjct: 333 TFASCS-TDMCIHVCRLGCDR------PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 385
Query: 178 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNT-------FVSGGCDKKAMVWDMRSGQ 230
+W ++ + H ++ + +P+ + S D +WD+ G
Sbjct: 386 KIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGV 445
Query: 231 CVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVD 290
C H+ + SV + P G ASGS D +++ ++ V Y IF V
Sbjct: 446 CTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIF---EVC 502
Query: 291 FSLSGRLLFAGYNDYTINVWDVLK 314
++ G + A +D ++ V D+ K
Sbjct: 503 WNARGDKVGASASDGSVCVLDLRK 526
Score = 56.6 bits (135), Expect = 3e-08
Identities = 55/257 (21%), Positives = 88/257 (34%), Gaps = 62/257 (24%)
Query: 108 VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMH-----------TNYL 156
V CA+ P +A G D+ ++ L + N + V H +
Sbjct: 184 VFICAWNPVSDLLASGSGDSTARIWNLNENSN---GGSTQLVLRHCIREGGHDVPSNKDV 240
Query: 157 SACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGG 216
++ + + + T S DG +W E G L + H + L + GN +S G
Sbjct: 241 TSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKW--NRKGNYILSAG 297
Query: 217 CDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAI 276
DK ++WD +G+ Q F H + V + + FAS S D + L DR V
Sbjct: 298 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKT 356
Query: 277 YSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPD 336
+ GH N V+ ++ P
Sbjct: 357 FQ--------------------------------------------GHTNEVNAIKWDPS 372
Query: 337 GTAFCSGSWDHTLRVWA 353
G S S D TL++W+
Sbjct: 373 GMLLASCSDDMTLKIWS 389
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 100 bits (249), Expect = 2e-21
Identities = 82/349 (23%), Positives = 148/349 (42%), Gaps = 37/349 (10%)
Query: 27 EEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGK 86
EE RA H V H ++ + L+GH ++V W + S S D
Sbjct: 147 EENRA--HSVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDST 204
Query: 87 VIVW---DSFTTNKEHAVTMPCTW-----------VMACAYAPSGCAIACGGLDNKCSVY 132
+W ++ V C V + + +G +A G D ++
Sbjct: 205 ARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW 264
Query: 133 PLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFH 192
++ N+A+ ++ H + A + IL+A D T +WD +G+ Q F
Sbjct: 265 ----TEDGNLAS---TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFP 317
Query: 193 GHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGD 252
H A L +D + TF S D V + + V+ F+ H +++N++++ PSG
Sbjct: 318 FHSAPALDVDW---QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGM 374
Query: 253 AFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGR---------LLFAGYN 303
AS SDD T +++ ++ +EV I+ ++ ++ +S +G +L +
Sbjct: 375 LLASCSDDMTLKIWSMK--QEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASF 432
Query: 304 DYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
D T+ +WD+ +G L H+ V ++ SPDG SGS+D + +W
Sbjct: 433 DSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIW 481
Score = 69.3 bits (168), Expect = 5e-12
Identities = 56/264 (21%), Positives = 102/264 (38%), Gaps = 17/264 (6%)
Query: 58 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 117
TL H + + W + I+S+ D I+WD+ T + + + +
Sbjct: 273 TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNT 332
Query: 118 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 177
+C D V L D+ K+ HTN ++A + S M + + S D T
Sbjct: 333 TFASCS-TDMCIHVCRLGCDR------PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 385
Query: 178 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNT-------FVSGGCDKKAMVWDMRSGQ 230
+W ++ + H ++ + +P+ + S D +WD+ G
Sbjct: 386 KIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGV 445
Query: 231 CVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVD 290
C H+ + SV + P G ASGS D +++ ++ V Y IF V
Sbjct: 446 CTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIF---EVC 502
Query: 291 FSLSGRLLFAGYNDYTINVWDVLK 314
++ G + A +D ++ V D+ K
Sbjct: 503 WNARGDKVGASASDGSVCVLDLRK 526
Score = 56.6 bits (135), Expect = 3e-08
Identities = 55/257 (21%), Positives = 88/257 (34%), Gaps = 62/257 (24%)
Query: 108 VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMH-----------TNYL 156
V CA+ P +A G D+ ++ L + N + V H +
Sbjct: 184 VFICAWNPVSDLLASGSGDSTARIWNLNENSN---GGSTQLVLRHCIREGGHDVPSNKDV 240
Query: 157 SACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGG 216
++ + + + T S DG +W E G L + H + L + GN +S G
Sbjct: 241 TSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKW--NRKGNYILSAG 297
Query: 217 CDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAI 276
DK ++WD +G+ Q F H + V + + FAS S D + L DR V
Sbjct: 298 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKT 356
Query: 277 YSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPD 336
+ GH N V+ ++ P
Sbjct: 357 FQ--------------------------------------------GHTNEVNAIKWDPS 372
Query: 337 GTAFCSGSWDHTLRVWA 353
G S S D TL++W+
Sbjct: 373 GMLLASCSDDMTLKIWS 389
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 100 bits (249), Expect = 2e-21
Identities = 82/349 (23%), Positives = 148/349 (42%), Gaps = 37/349 (10%)
Query: 27 EEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGK 86
EE RA H V H ++ + L+GH ++V W + S S D
Sbjct: 198 EENRA--HSVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDST 255
Query: 87 VIVW---DSFTTNKEHAVTMPCTW-----------VMACAYAPSGCAIACGGLDNKCSVY 132
+W ++ V C V + + +G +A G D ++
Sbjct: 256 ARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW 315
Query: 133 PLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFH 192
++ N+A+ ++ H + A + IL+A D T +WD +G+ Q F
Sbjct: 316 ----TEDGNLAS---TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFP 368
Query: 193 GHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGD 252
H A L +D + TF S D V + + V+ F+ H +++N++++ PSG
Sbjct: 369 FHSAPALDVDW---QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGM 425
Query: 253 AFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGR---------LLFAGYN 303
AS SDD T +++ ++ +EV I+ ++ ++ +S +G +L +
Sbjct: 426 LLASCSDDMTLKIWSMK--QEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASF 483
Query: 304 DYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
D T+ +WD+ +G L H+ V ++ SPDG SGS+D + +W
Sbjct: 484 DSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIW 532
Score = 69.3 bits (168), Expect = 5e-12
Identities = 56/264 (21%), Positives = 102/264 (38%), Gaps = 17/264 (6%)
Query: 58 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 117
TL H + + W + I+S+ D I+WD+ T + + + +
Sbjct: 324 TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNT 383
Query: 118 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 177
+C D V L D+ K+ HTN ++A + S M + + S D T
Sbjct: 384 TFASCS-TDMCIHVCRLGCDR------PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 436
Query: 178 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNT-------FVSGGCDKKAMVWDMRSGQ 230
+W ++ + H ++ + +P+ + S D +WD+ G
Sbjct: 437 KIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGV 496
Query: 231 CVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVD 290
C H+ + SV + P G ASGS D +++ ++ V Y IF V
Sbjct: 497 CTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIF---EVC 553
Query: 291 FSLSGRLLFAGYNDYTINVWDVLK 314
++ G + A +D ++ V D+ K
Sbjct: 554 WNARGDKVGASASDGSVCVLDLRK 577
Score = 56.6 bits (135), Expect = 3e-08
Identities = 55/257 (21%), Positives = 88/257 (34%), Gaps = 62/257 (24%)
Query: 108 VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMH-----------TNYL 156
V CA+ P +A G D+ ++ L + N + V H +
Sbjct: 235 VFICAWNPVSDLLASGSGDSTARIWNLNENSN---GGSTQLVLRHCIREGGHDVPSNKDV 291
Query: 157 SACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGG 216
++ + + + T S DG +W E G L + H + L + GN +S G
Sbjct: 292 TSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKW--NRKGNYILSAG 348
Query: 217 CDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAI 276
DK ++WD +G+ Q F H + V + + FAS S D + L DR V
Sbjct: 349 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKT 407
Query: 277 YSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPD 336
+ GH N V+ ++ P
Sbjct: 408 FQ--------------------------------------------GHTNEVNAIKWDPS 423
Query: 337 GTAFCSGSWDHTLRVWA 353
G S S D TL++W+
Sbjct: 424 GMLLASCSDDMTLKIWS 440
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 100 bits (249), Expect = 2e-21
Identities = 82/349 (23%), Positives = 148/349 (42%), Gaps = 37/349 (10%)
Query: 27 EEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGK 86
EE RA H V H ++ + L+GH ++V W + S S D
Sbjct: 198 EENRA--HSVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDST 255
Query: 87 VIVW---DSFTTNKEHAVTMPCTW-----------VMACAYAPSGCAIACGGLDNKCSVY 132
+W ++ V C V + + +G +A G D ++
Sbjct: 256 ARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW 315
Query: 133 PLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFH 192
++ N+A+ ++ H + A + IL+A D T +WD +G+ Q F
Sbjct: 316 ----TEDGNLAS---TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFP 368
Query: 193 GHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGD 252
H A L +D + TF S D V + + V+ F+ H +++N++++ PSG
Sbjct: 369 FHSAPALDVDW---QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGM 425
Query: 253 AFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGR---------LLFAGYN 303
AS SDD T +++ ++ +EV I+ ++ ++ +S +G +L +
Sbjct: 426 LLASCSDDMTLKIWSMK--QEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASF 483
Query: 304 DYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
D T+ +WD+ +G L H+ V ++ SPDG SGS+D + +W
Sbjct: 484 DSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIW 532
Score = 69.3 bits (168), Expect = 5e-12
Identities = 56/264 (21%), Positives = 102/264 (38%), Gaps = 17/264 (6%)
Query: 58 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 117
TL H + + W + I+S+ D I+WD+ T + + + +
Sbjct: 324 TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNT 383
Query: 118 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 177
+C D V L D+ K+ HTN ++A + S M + + S D T
Sbjct: 384 TFASCS-TDMCIHVCRLGCDR------PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 436
Query: 178 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNT-------FVSGGCDKKAMVWDMRSGQ 230
+W ++ + H ++ + +P+ + S D +WD+ G
Sbjct: 437 KIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGV 496
Query: 231 CVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVD 290
C H+ + SV + P G ASGS D +++ ++ V Y IF V
Sbjct: 497 CTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIF---EVC 553
Query: 291 FSLSGRLLFAGYNDYTINVWDVLK 314
++ G + A +D ++ V D+ K
Sbjct: 554 WNARGDKVGASASDGSVCVLDLRK 577
Score = 56.6 bits (135), Expect = 3e-08
Identities = 55/257 (21%), Positives = 88/257 (34%), Gaps = 62/257 (24%)
Query: 108 VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMH-----------TNYL 156
V CA+ P +A G D+ ++ L + N + V H +
Sbjct: 235 VFICAWNPVSDLLASGSGDSTARIWNLNENSN---GGSTQLVLRHCIREGGHDVPSNKDV 291
Query: 157 SACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGG 216
++ + + + T S DG +W E G L + H + L + GN +S G
Sbjct: 292 TSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKW--NRKGNYILSAG 348
Query: 217 CDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAI 276
DK ++WD +G+ Q F H + V + + FAS S D + L DR V
Sbjct: 349 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKT 407
Query: 277 YSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPD 336
+ GH N V+ ++ P
Sbjct: 408 FQ--------------------------------------------GHTNEVNAIKWDPS 423
Query: 337 GTAFCSGSWDHTLRVWA 353
G S S D TL++W+
Sbjct: 424 GMLLASCSDDMTLKIWS 440
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 100 bits (249), Expect = 2e-21
Identities = 81/360 (22%), Positives = 148/360 (41%), Gaps = 31/360 (8%)
Query: 14 SLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCK 73
S ++ ++ + + E H++ H ++ + L+GH ++V W
Sbjct: 130 SQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHESEVFICAWNP 189
Query: 74 DKRRIVSSSQDGKVIVW---DSFTTNKEHAVTMPCTW-----------VMACAYAPSGCA 119
+ S S D +W ++ V C V + + G
Sbjct: 190 VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTL 249
Query: 120 IACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCAL 179
+A G D ++ +N N+A+ ++ H + A + +L+A D T +
Sbjct: 250 LAMGSYDGFARIWT----ENGNLAS---TLGQHKGPIFALKWNKKGNYVLSAGVDKTTII 302
Query: 180 WDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHE 239
WD +G+ Q F H A L +D + TF S D V + V+ F+ H
Sbjct: 303 WDAHTGEAKQQFPFHSAPALDVDW---QNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHT 359
Query: 240 SDINSVRYYPSGDAFASGSDDATCRLYDLRAD---REVAIYSKESIIFGASSVDFSLSGR 296
+++N++++ PSG AS SDD T +++ ++ D ++ +SKE S + S
Sbjct: 360 NEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNP 419
Query: 297 ----LLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
+L + D T+ +WDV +G L H+ V ++ SPDG SGS+D + +W
Sbjct: 420 NSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIW 479
Score = 67.4 bits (163), Expect = 2e-11
Identities = 55/262 (20%), Positives = 100/262 (38%), Gaps = 17/262 (6%)
Query: 58 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 117
TL H + + W K ++S+ D I+WD+ T + + + +
Sbjct: 271 TLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNM 330
Query: 118 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 177
+C D V L D K+ HTN ++A + S M + + S D T
Sbjct: 331 TFASCS-TDMCIHVCRLGCDH------PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 383
Query: 178 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNT-------FVSGGCDKKAMVWDMRSGQ 230
+W ++ + H ++ + +P+ + S D +WD+ G
Sbjct: 384 KIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGV 443
Query: 231 CVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVD 290
C H+ + SV + P G ASGS D +++ ++ V Y IF V
Sbjct: 444 CTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGGIF---EVC 500
Query: 291 FSLSGRLLFAGYNDYTINVWDV 312
++ G + A +D ++ V D+
Sbjct: 501 WNARGDKVGASASDGSVCVLDL 522
Score = 52.4 bits (124), Expect = 6e-07
Identities = 55/238 (23%), Positives = 94/238 (39%), Gaps = 25/238 (10%)
Query: 133 PLTFDKNENMAAKKKSVAM-HTNYLSACSFTNSDMQILTASGDGTCALWDVE------SG 185
P+ D + + K +V H + + C++ + + SGD T +W++ S
Sbjct: 158 PMEIDGDVEIPPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGST 217
Query: 186 QLLQSF----HGHGA----DVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFET 237
QL+ GH DV LD + G G D A +W +G
Sbjct: 218 QLVLRHCIREGGHDVPSNKDVTSLDW--NSDGTLLAMGSYDGFARIWT-ENGNLASTLGQ 274
Query: 238 HESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIF-GASSVDFSLSGR 296
H+ I ++++ G+ S D T ++D +K+ F A ++D
Sbjct: 275 HKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGE-----AKQQFPFHSAPALDVDWQNN 329
Query: 297 LLFAGYN-DYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 353
+ FA + D I+V + V GH N V+ ++ P G S S D TL++W+
Sbjct: 330 MTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWS 387
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 100 bits (249), Expect = 2e-21
Identities = 81/360 (22%), Positives = 148/360 (41%), Gaps = 31/360 (8%)
Query: 14 SLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCK 73
S ++ ++ + + E H++ H ++ + L+GH ++V W
Sbjct: 130 SQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHESEVFICAWNP 189
Query: 74 DKRRIVSSSQDGKVIVW---DSFTTNKEHAVTMPCTW-----------VMACAYAPSGCA 119
+ S S D +W ++ V C V + + G
Sbjct: 190 VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTL 249
Query: 120 IACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCAL 179
+A G D ++ +N N+A+ ++ H + A + +L+A D T +
Sbjct: 250 LAMGSYDGFARIWT----ENGNLAS---TLGQHKGPIFALKWNKKGNYVLSAGVDKTTII 302
Query: 180 WDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHE 239
WD +G+ Q F H A L +D + TF S D V + V+ F+ H
Sbjct: 303 WDAHTGEAKQQFPFHSAPALDVDW---QNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHT 359
Query: 240 SDINSVRYYPSGDAFASGSDDATCRLYDLRAD---REVAIYSKESIIFGASSVDFSLSGR 296
+++N++++ PSG AS SDD T +++ ++ D ++ +SKE S + S
Sbjct: 360 NEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNP 419
Query: 297 ----LLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
+L + D T+ +WDV +G L H+ V ++ SPDG SGS+D + +W
Sbjct: 420 NSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIW 479
Score = 67.4 bits (163), Expect = 2e-11
Identities = 55/262 (20%), Positives = 100/262 (38%), Gaps = 17/262 (6%)
Query: 58 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 117
TL H + + W K ++S+ D I+WD+ T + + + +
Sbjct: 271 TLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNM 330
Query: 118 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 177
+C D V L D K+ HTN ++A + S M + + S D T
Sbjct: 331 TFASCS-TDMCIHVCRLGCDH------PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 383
Query: 178 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNT-------FVSGGCDKKAMVWDMRSGQ 230
+W ++ + H ++ + +P+ + S D +WD+ G
Sbjct: 384 KIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGV 443
Query: 231 CVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVD 290
C H+ + SV + P G ASGS D +++ ++ V Y IF V
Sbjct: 444 CTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGGIF---EVC 500
Query: 291 FSLSGRLLFAGYNDYTINVWDV 312
++ G + A +D ++ V D+
Sbjct: 501 WNARGDKVGASASDGSVCVLDL 522
Score = 52.4 bits (124), Expect = 6e-07
Identities = 55/238 (23%), Positives = 94/238 (39%), Gaps = 25/238 (10%)
Query: 133 PLTFDKNENMAAKKKSVAM-HTNYLSACSFTNSDMQILTASGDGTCALWDVE------SG 185
P+ D + + K +V H + + C++ + + SGD T +W++ S
Sbjct: 158 PMEIDGDVEIPPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGST 217
Query: 186 QLLQSF----HGHGA----DVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFET 237
QL+ GH DV LD + G G D A +W +G
Sbjct: 218 QLVLRHCIREGGHDVPSNKDVTSLDW--NSDGTLLAMGSYDGFARIWT-ENGNLASTLGQ 274
Query: 238 HESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIF-GASSVDFSLSGR 296
H+ I ++++ G+ S D T ++D +K+ F A ++D
Sbjct: 275 HKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGE-----AKQQFPFHSAPALDVDWQNN 329
Query: 297 LLFAGYN-DYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 353
+ FA + D I+V + V GH N V+ ++ P G S S D TL++W+
Sbjct: 330 MTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWS 387
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 100 bits (249), Expect = 2e-21
Identities = 81/360 (22%), Positives = 148/360 (41%), Gaps = 31/360 (8%)
Query: 14 SLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCK 73
S ++ ++ + + E H++ H ++ + L+GH ++V W
Sbjct: 130 SQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHESEVFICAWNP 189
Query: 74 DKRRIVSSSQDGKVIVW---DSFTTNKEHAVTMPCTW-----------VMACAYAPSGCA 119
+ S S D +W ++ V C V + + G
Sbjct: 190 VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTL 249
Query: 120 IACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCAL 179
+A G D ++ +N N+A+ ++ H + A + +L+A D T +
Sbjct: 250 LAMGSYDGFARIWT----ENGNLAS---TLGQHKGPIFALKWNKKGNYVLSAGVDKTTII 302
Query: 180 WDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHE 239
WD +G+ Q F H A L +D + TF S D V + V+ F+ H
Sbjct: 303 WDAHTGEAKQQFPFHSAPALDVDW---QNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHT 359
Query: 240 SDINSVRYYPSGDAFASGSDDATCRLYDLRAD---REVAIYSKESIIFGASSVDFSLSGR 296
+++N++++ PSG AS SDD T +++ ++ D ++ +SKE S + S
Sbjct: 360 NEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNP 419
Query: 297 ----LLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
+L + D T+ +WDV +G L H+ V ++ SPDG SGS+D + +W
Sbjct: 420 NSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIW 479
Score = 67.4 bits (163), Expect = 2e-11
Identities = 55/262 (20%), Positives = 100/262 (38%), Gaps = 17/262 (6%)
Query: 58 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 117
TL H + + W K ++S+ D I+WD+ T + + + +
Sbjct: 271 TLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNM 330
Query: 118 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 177
+C D V L D K+ HTN ++A + S M + + S D T
Sbjct: 331 TFASCS-TDMCIHVCRLGCDH------PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 383
Query: 178 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNT-------FVSGGCDKKAMVWDMRSGQ 230
+W ++ + H ++ + +P+ + S D +WD+ G
Sbjct: 384 KIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGV 443
Query: 231 CVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVD 290
C H+ + SV + P G ASGS D +++ ++ V Y IF V
Sbjct: 444 CTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGGIF---EVC 500
Query: 291 FSLSGRLLFAGYNDYTINVWDV 312
++ G + A +D ++ V D+
Sbjct: 501 WNARGDKVGASASDGSVCVLDL 522
Score = 52.4 bits (124), Expect = 6e-07
Identities = 55/238 (23%), Positives = 94/238 (39%), Gaps = 25/238 (10%)
Query: 133 PLTFDKNENMAAKKKSVAM-HTNYLSACSFTNSDMQILTASGDGTCALWDVE------SG 185
P+ D + + K +V H + + C++ + + SGD T +W++ S
Sbjct: 158 PMEIDGDVEIPPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGST 217
Query: 186 QLLQSF----HGHGA----DVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFET 237
QL+ GH DV LD + G G D A +W +G
Sbjct: 218 QLVLRHCIREGGHDVPSNKDVTSLDW--NSDGTLLAMGSYDGFARIWT-ENGNLASTLGQ 274
Query: 238 HESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIF-GASSVDFSLSGR 296
H+ I ++++ G+ S D T ++D +K+ F A ++D
Sbjct: 275 HKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGE-----AKQQFPFHSAPALDVDWQNN 329
Query: 297 LLFAGYN-DYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 353
+ FA + D I+V + V GH N V+ ++ P G S S D TL++W+
Sbjct: 330 MTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWS 387
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 99.4 bits (246), Expect = 4e-21
Identities = 66/225 (29%), Positives = 105/225 (46%), Gaps = 20/225 (8%)
Query: 146 KKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAP 205
++++ HT+ + SF +S + + S D T LWD + + +++ HGH +V + + P
Sbjct: 143 ERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMP 202
Query: 206 SETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRL 265
+ G+ VS DK +W++++G CV+ F H + VR G AS S+D T R+
Sbjct: 203 N--GDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRV 260
Query: 266 Y---------DLRADREV---------AIYSKESIIFGASSVDFSLSGRLLFAGYNDYTI 307
+ +LR V + YS S G+ + G L +G D TI
Sbjct: 261 WVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTI 320
Query: 308 NVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
+WDV G + L GH+N V + G S + D TLRVW
Sbjct: 321 KMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365
Score = 67.4 bits (163), Expect = 2e-11
Identities = 61/273 (22%), Positives = 104/273 (38%), Gaps = 26/273 (9%)
Query: 57 RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 116
RTLKGH + V + + + + S S D + +WD + V + A P+
Sbjct: 144 RTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPN 203
Query: 117 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT 176
G I D ++ + K+ H ++ I + S D T
Sbjct: 204 GDHIVSASRDKTIKMWEV------QTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQT 257
Query: 177 CALWDVESGQLLQSFHGHGADVLCLDLAP------------SET------GNTFVSGGCD 218
+W V + + H V C+ AP SET G +SG D
Sbjct: 258 VRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRD 317
Query: 219 KKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYS 278
K +WD+ +G C+ H++ + V ++ G S +DD T R++D + R + +
Sbjct: 318 KTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLN 377
Query: 279 KESIIFGASSVDFSLSGRLLFAGYNDYTINVWD 311
+S+DF + + G D T+ VW+
Sbjct: 378 AHEHF--VTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 65.9 bits (159), Expect = 5e-11
Identities = 54/227 (23%), Positives = 95/227 (41%), Gaps = 16/227 (7%)
Query: 57 RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 116
RT+ GH + V + + IVS+S+D + +W+ T T WV
Sbjct: 186 RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQD 245
Query: 117 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSV------AMHTNYLSACSFTNSDMQ--- 167
G IA D V+ + + + + + V A ++Y S T S+ +
Sbjct: 246 GTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSG 305
Query: 168 -----ILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAM 222
+L+ S D T +WDV +G L + GH D + G +S DK
Sbjct: 306 KPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGH--DNWVRGVLFHSGGKFILSCADDKTLR 363
Query: 223 VWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLR 269
VWD ++ +C++ HE + S+ ++ + +GS D T ++++ R
Sbjct: 364 VWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
Score = 60.8 bits (146), Expect = 2e-09
Identities = 43/159 (27%), Positives = 72/159 (45%), Gaps = 8/159 (5%)
Query: 198 VLCLDLAPSETGNTFVSGGC---DKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAF 254
V+ L+ +E F SGG + W R + A H S + V ++P
Sbjct: 65 VMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPE-KYALSGHRSPVTRVIFHPVFSVM 123
Query: 255 ASGSDDATCRLYDLRA-DREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVL 313
S S+DAT +++D D E + + + F SG+LL + D TI +WD
Sbjct: 124 VSASEDATIKVWDYETGDFERTLKGHTDSV---QDISFDHSGKLLASCSADMTIKLWDFQ 180
Query: 314 KGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
+ + GH++ VS++ + P+G S S D T+++W
Sbjct: 181 GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMW 219
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 99.4 bits (246), Expect = 4e-21
Identities = 58/224 (25%), Positives = 107/224 (47%), Gaps = 4/224 (1%)
Query: 129 CSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLL 188
C + D+++N + K + H + + F +L+ S D + WD+ S
Sbjct: 318 CDILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNT 377
Query: 189 QSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYY 248
+ GH V LD++P F SG D+ A +W ++ + H +D++ V+++
Sbjct: 378 VLYQGHAYPVWDLDISPYSL--YFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFH 435
Query: 249 PSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTIN 308
P+ + A+GS D T RL+ + V +++ S+ FS +G+ L + D +
Sbjct: 436 PNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHR--GPVLSLAFSPNGKYLASAGEDQRLK 493
Query: 309 VWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
+WD+ G+ L GH + +++L SPD S S D+++RVW
Sbjct: 494 LWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537
Score = 75.9 bits (185), Expect = 5e-14
Identities = 56/215 (26%), Positives = 92/215 (42%), Gaps = 12/215 (5%)
Query: 57 RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWD--SFTTNKEHAVTMPCTWVMACAYA 114
+ L+GH V + D ++S S+D + WD SFT + W + +
Sbjct: 336 KILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDL--DIS 393
Query: 115 PSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGD 174
P A G D ++ +FD+ + + A H + F + + T S D
Sbjct: 394 PYSLYFASGSHDRTARLW--SFDRTYPL----RIYAGHLADVDCVKFHPNSNYLATGSTD 447
Query: 175 GTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQA 234
T LW + G ++ F GH VL L +P+ G S G D++ +WD+ SG +
Sbjct: 448 KTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPN--GKYLASAGEDQRLKLWDLASGTLYKE 505
Query: 235 FETHESDINSVRYYPSGDAFASGSDDATCRLYDLR 269
H +I S+ + P AS S D + R++D+R
Sbjct: 506 LRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIR 540
Score = 51.2 bits (121), Expect = 1e-06
Identities = 47/205 (22%), Positives = 83/205 (40%), Gaps = 19/205 (9%)
Query: 152 HTNYLSACSFTNSDMQILTASGDGTCA-LWDVESGQLLQSFHGHGADVLCLDLAPSETGN 210
+T L + + D ++L A D +C LW + S +L H DV + LA
Sbjct: 266 NTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSE--PHQVDVSRIHLA------ 317
Query: 211 TFVSGGCD--KKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDL 268
CD ++ D +G ++ H + S R+ S S+D + R +DL
Sbjct: 318 ------CDILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL 371
Query: 269 RADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRV 328
+ +Y + + +D S +G +D T +W + + I GH V
Sbjct: 372 GSFTNTVLYQGHA--YPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADV 429
Query: 329 STLRVSPDGTAFCSGSWDHTLRVWA 353
++ P+ +GS D T+R+W+
Sbjct: 430 DCVKFHPNSNYLATGSTDKTVRLWS 454
Score = 43.1 bits (100), Expect = 4e-04
Identities = 29/128 (22%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 57 RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 116
R GH V C+ + + + + S D V +W + N T V++ A++P+
Sbjct: 420 RIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPN 479
Query: 117 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT 176
G +A G D + ++ L K + HT+ +++ +F+ I +AS D +
Sbjct: 480 GKYLASAGEDQRLKLWDLA------SGTLYKELRGHTDNITSLTFSPDSGLIASASMDNS 533
Query: 177 CALWDVES 184
+WD+ +
Sbjct: 534 VRVWDIRN 541
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 99.0 bits (245), Expect = 6e-21
Identities = 64/202 (31%), Positives = 97/202 (48%), Gaps = 4/202 (1%)
Query: 152 HTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNT 211
HT + C F+ +AS D T LWDV + L+ GH V + +P
Sbjct: 62 HTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDS--RQ 119
Query: 212 FVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLR-A 270
SGG DK+ M+WD++SGQ ++ H I S + P+ + A+GS D+T ++DLR
Sbjct: 120 LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV 179
Query: 271 DREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVST 330
V+ + E S + +S SG LL +G D TI++W S + L GH V +
Sbjct: 180 TPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKS 238
Query: 331 LRVSPDGTAFCSGSWDHTLRVW 352
+ SPD S + ++VW
Sbjct: 239 IAFSPDELWLASAGYSRMVKVW 260
Score = 98.2 bits (243), Expect = 1e-20
Identities = 62/211 (29%), Positives = 97/211 (45%), Gaps = 12/211 (5%)
Query: 147 KSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPS 206
K H +++ +F+ +LT S DG W+ SGQLL GH V +P
Sbjct: 15 KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD 74
Query: 207 ETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLY 266
G+ F S CD +WD+ +C++ + H+ + +V + P ASG D L+
Sbjct: 75 --GHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLW 132
Query: 267 DLRADR--EVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWD---VLKGSRVSIL 321
D+++ + + + ++SI S DFS + L G D T+++WD V L
Sbjct: 133 DVQSGQMLRLLVGHRDSI----QSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQAL 188
Query: 322 FGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
GH +S L S G SGSWD T+ +W
Sbjct: 189 EGHSANISCLCYSASG-LLASGSWDKTIHIW 218
Score = 87.0 bits (214), Expect = 2e-17
Identities = 75/292 (25%), Positives = 121/292 (41%), Gaps = 14/292 (4%)
Query: 62 HGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIA 121
HG +V + D + +++ S+DG V W++ + + V C ++P G A
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 122 CGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWD 181
D C+V + + + K H + SF+ Q+ + D LWD
Sbjct: 80 SASCD--CTVRLWDVARAKCLRVLKG----HQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
Query: 182 VESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRS---GQCVQAFETH 238
V+SGQ+L+ GH + D +P T N +G D +WD+R QA E H
Sbjct: 134 VQSGQMLRLLVGHRDSIQSSDFSP--TVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGH 191
Query: 239 ESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLL 298
++I+ + Y SG ASGS D T ++ + + + + S+ FS L
Sbjct: 192 SANISCLCYSASG-LLASGSWDKTIHIW--KPTTSSLLIQLKGHVTWVKSIAFSPDELWL 248
Query: 299 FAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLR 350
+ + VWD G + L G + T +PDG SG+ D T R
Sbjct: 249 ASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
Score = 68.6 bits (166), Expect = 8e-12
Identities = 48/211 (22%), Positives = 91/211 (43%), Gaps = 6/211 (2%)
Query: 54 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAY 113
K R LKGH V + + D R++ S D +V++WD + + + + +
Sbjct: 96 KCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDF 155
Query: 114 APSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASG 173
+P+ +A G D+ ++ L + A +++ H+ +S ++ S + + + S
Sbjct: 156 SPTVNCLATGSWDSTVHIWDL---RMVTPAVSHQALEGHSANISCLCYSASGL-LASGSW 211
Query: 174 DGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQ 233
D T +W + LL GH V + +P E S G + VWD +G+C++
Sbjct: 212 DKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDEL--WLASAGYSRMVKVWDCNTGKCLE 269
Query: 234 AFETHESDINSVRYYPSGDAFASGSDDATCR 264
+ ++ + P G SG+ D T R
Sbjct: 270 TLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
Score = 62.0 bits (149), Expect = 8e-10
Identities = 33/121 (27%), Positives = 55/121 (45%), Gaps = 2/121 (1%)
Query: 232 VQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDF 291
V+ F H ++NS + P G +GS+D ++ R+ + ++ F
Sbjct: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQ--LLWRLGGHTGPVKFCRF 71
Query: 292 SLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRV 351
S G L + D T+ +WDV + + +L GH+ V T+ SPD SG WD + +
Sbjct: 72 SPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVML 131
Query: 352 W 352
W
Sbjct: 132 W 132
>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
Length = 1336
Score = 99.0 bits (245), Expect = 6e-21
Identities = 85/310 (27%), Positives = 138/310 (44%), Gaps = 26/310 (8%)
Query: 55 TRRTLKGHGNKVLC----MDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMA 110
T + ++ NKV C + W + RR+V+ + G+ +W+ T N E + + V A
Sbjct: 107 TTKFVRTSTNKVKCPVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRA 166
Query: 111 CAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILT 170
++ + + L Y + N N K H + SF+ +D + T
Sbjct: 167 MTWSHNDMWM----LTADHGGYVKYWQSNMNNV---KMFQAHKEAIREASFSPTDNKFAT 219
Query: 171 ASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMV--WDMRS 228
S DGT +WD + GHGADV C+D P T VSG D + + WD ++
Sbjct: 220 CSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHP--TKGLVVSGSKDSQQPIKFWDPKT 277
Query: 229 GQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLR-ADREVAIY---SKESIIF 284
GQ + H++ + V+ +G+ + S D C+L+D+R E+ ++ KE
Sbjct: 278 GQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKE---- 333
Query: 285 GASSVDFSLSGRLLFA-GYNDYTINVWDVLKGSRV-SILFGHENRVSTLRVSPDGTAFCS 342
A++V + LFA G +D ++ W V V + HE + +L P G CS
Sbjct: 334 -ATAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILCS 392
Query: 343 GSWDHTLRVW 352
GS DHT + W
Sbjct: 393 GSNDHTSKFW 402
Score = 61.2 bits (147), Expect = 1e-09
Identities = 52/216 (24%), Positives = 87/216 (40%), Gaps = 7/216 (3%)
Query: 53 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACA 112
M + + H + + + + S DG V +WD ++E + V
Sbjct: 192 MNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVD 251
Query: 113 YAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTAS 172
+ P+ + G D S P+ F + ++ H N + + +LTAS
Sbjct: 252 WHPTKGLVVSGSKD---SQQPIKF-WDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTAS 307
Query: 173 GDGTCALWDVES-GQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQC 231
D C L+D+ + + LQ F GH + + P G F SGG D + W + +
Sbjct: 308 RDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEG-LFASGGSDGSLLFWHVGVEKE 366
Query: 232 VQAFE-THESDINSVRYYPSGDAFASGSDDATCRLY 266
V E HE I S+ ++P G SGS+D T + +
Sbjct: 367 VGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSKFW 402
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 98.2 bits (243), Expect = 1e-20
Identities = 80/307 (26%), Positives = 133/307 (43%), Gaps = 17/307 (5%)
Query: 50 QFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMP---CT 106
+F K + + H V C+ K +VS +D +W K + +
Sbjct: 339 KFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDR---LWKVLGLPKCNVLLTGFGHTD 395
Query: 107 WVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDM 166
W+ C + PSG +A D ++ L K + + + H+ + +C++ +
Sbjct: 396 WLSDCCFHPSGDKLATSSGDTTVKLWDLC--KGDCILTFEG----HSRAVWSCTWHSCGN 449
Query: 167 QILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDM 226
+ ++S D T +WDV S + + +GH V ++ P NT ++ DK +WD
Sbjct: 450 FVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFS--NTLLTSSADKTLSIWDA 507
Query: 227 RSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGA 286
R+G C Q+ H IN + P G AS +L+D R + + I S +
Sbjct: 508 RTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFR--KLLPIVSIDIGPSPG 565
Query: 287 SSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWD 346
+ V+F SGR+L + I++ D LK + L GHEN T+ S DG SG D
Sbjct: 566 NEVNFDSSGRVLAQASGNGVIHLLD-LKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSD 624
Query: 347 HTLRVWA 353
T+R W+
Sbjct: 625 GTVRTWS 631
Score = 64.7 bits (156), Expect = 1e-10
Identities = 65/274 (23%), Positives = 110/274 (40%), Gaps = 28/274 (10%)
Query: 97 KEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVA------ 150
KE+A P + A + C G + K S +P+ N N+ K+S++
Sbjct: 284 KENAPEGPTQKGLREAREQNKCKTKMKG-NTKDSEFPIDMQPNPNLNVSKESLSPAKFDY 342
Query: 151 -------MHTNYLSACSFTNSDMQILTASGDGTCALWDV----ESGQLLQSFHGHGADVL 199
+H +S C IL + G+ LW V + LL F GH D L
Sbjct: 343 KLKNIFRLHELPVS-CVSMQPHKDILVSCGEDR--LWKVLGLPKCNVLLTGF-GH-TDWL 397
Query: 200 CLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSD 259
D +G+ + D +WD+ G C+ FE H + S ++ G+ AS S
Sbjct: 398 S-DCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSL 456
Query: 260 DATCRLYDLRADR-EVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRV 318
D T +++D+ ++R +Y + +S++F L D T+++WD G
Sbjct: 457 DKTSKIWDVNSERCRCTLYGHTDSV---NSIEFFPFSNTLLTSSADKTLSIWDARTGICE 513
Query: 319 SILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
L+GH + ++ P G S ++W
Sbjct: 514 QSLYGHMHSINDAIFDPRGHMIASCDACGVTKLW 547
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.131 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,364,787
Number of Sequences: 37866
Number of extensions: 569207
Number of successful extensions: 4829
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 253
Number of HSP's successfully gapped in prelim test: 76
Number of HSP's that attempted gapping in prelim test: 1765
Number of HSP's gapped (non-prelim): 1484
length of query: 353
length of database: 18,247,518
effective HSP length: 103
effective length of query: 250
effective length of database: 14,347,320
effective search space: 3586830000
effective search space used: 3586830000
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.