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Search of human proteins with 56243583
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|56243583 WD repeat domain 18 [Homo sapiens]
(432 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|56243583 WD repeat domain 18 [Homo sapiens] 881 0.0
gi|32189425 WD repeat domain 69 [Homo sapiens] 79 6e-15
gi|21071067 TBP-associated factor 5 [Homo sapiens] 75 2e-13
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 69 8e-12
gi|23199987 WD repeat domain 5B [Homo sapiens] 67 3e-11
gi|118402582 cell division cycle 20 [Homo sapiens] 66 5e-11
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 66 5e-11
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 66 7e-11
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 66 7e-11
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 66 7e-11
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 65 9e-11
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 65 9e-11
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ... 65 9e-11
gi|16554629 WD repeat domain 5 [Homo sapiens] 65 2e-10
gi|16554627 WD repeat domain 5 [Homo sapiens] 65 2e-10
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 63 5e-10
gi|113865883 WD repeat domain 38 [Homo sapiens] 62 8e-10
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is... 60 5e-09
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i... 60 5e-09
gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo ... 60 5e-09
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 59 7e-09
gi|89886480 zinedin isoform 2 [Homo sapiens] 59 9e-09
gi|89886477 zinedin isoform 1 [Homo sapiens] 59 9e-09
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 59 9e-09
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 59 9e-09
gi|4759276 RNA, U3 small nucleolar interacting protein 2 [Homo s... 58 1e-08
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 58 1e-08
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 58 1e-08
gi|148727341 serine/threonine kinase receptor associated protein... 58 2e-08
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 57 2e-08
>gi|56243583 WD repeat domain 18 [Homo sapiens]
Length = 432
Score = 881 bits (2276), Expect = 0.0
Identities = 432/432 (100%), Positives = 432/432 (100%)
Query: 1 MAAPMEVAVCTDSAAPMWSCIVWELHSGANLLTYRGGQAGPRGLALLNGEYLLAAQLGKN 60
MAAPMEVAVCTDSAAPMWSCIVWELHSGANLLTYRGGQAGPRGLALLNGEYLLAAQLGKN
Sbjct: 1 MAAPMEVAVCTDSAAPMWSCIVWELHSGANLLTYRGGQAGPRGLALLNGEYLLAAQLGKN 60
Query: 61 YISAWELQRKDQLQQKIMCPGPVTCLTASPNGLYVLAGVAESIHLWEVSTGNLLVILSRH 120
YISAWELQRKDQLQQKIMCPGPVTCLTASPNGLYVLAGVAESIHLWEVSTGNLLVILSRH
Sbjct: 61 YISAWELQRKDQLQQKIMCPGPVTCLTASPNGLYVLAGVAESIHLWEVSTGNLLVILSRH 120
Query: 121 YQDVSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLHC 180
YQDVSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLHC
Sbjct: 121 YQDVSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLHC 180
Query: 181 GFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGSEGSIF 240
GFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGSEGSIF
Sbjct: 181 GFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGSEGSIF 240
Query: 241 QVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQS 300
QVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQS
Sbjct: 241 QVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQS 300
Query: 301 KQCIRTVALKGPVTNAAILLAPVSMLSSDFRPSLPLPHFNKHLLGAEHGDEPRHGGLTLR 360
KQCIRTVALKGPVTNAAILLAPVSMLSSDFRPSLPLPHFNKHLLGAEHGDEPRHGGLTLR
Sbjct: 301 KQCIRTVALKGPVTNAAILLAPVSMLSSDFRPSLPLPHFNKHLLGAEHGDEPRHGGLTLR 360
Query: 361 LGLHQQGSEPSYLDRTEQLQAVLCSTMEKSVLGGQDQLRVRVTELEDEVRNLRKINRDLF 420
LGLHQQGSEPSYLDRTEQLQAVLCSTMEKSVLGGQDQLRVRVTELEDEVRNLRKINRDLF
Sbjct: 361 LGLHQQGSEPSYLDRTEQLQAVLCSTMEKSVLGGQDQLRVRVTELEDEVRNLRKINRDLF 420
Query: 421 DFSTRFITRPAK 432
DFSTRFITRPAK
Sbjct: 421 DFSTRFITRPAK 432
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 79.3 bits (194), Expect = 6e-15
Identities = 67/293 (22%), Positives = 123/293 (41%), Gaps = 28/293 (9%)
Query: 19 SCIVWELHSGANLLTYRGGQAGPRGLALLN--GEYLLAAQLGKNYISAWELQRKDQLQQK 76
+C +W+ SG L T G + +A N G+ + K W ++
Sbjct: 115 TCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKT-CKLWSVETGKCYHTF 173
Query: 77 IMCPGPVTCLTASPNGLYVLAGVAESI-HLWEVSTGNLLVILSRHYQDVSCLQFTGDSSH 135
+ CL+ +P V G ++ LW++ G + L H ++ L F
Sbjct: 174 RGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDR 233
Query: 136 FISGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLD 195
I+G D V+VW AD R ++ H I+ F + + T S+D
Sbjct: 234 IITGSFDHTVVVWD------ADTGR---KVNILIGHCAEISS--ASFNWDCSLILTGSMD 282
Query: 196 QTVKLWEVSSGELLLSVL-FDVSIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERS 254
+T KLW+ ++G+ + ++ D I+ D + ++G+ R S
Sbjct: 283 KTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTA-----------RIFS 331
Query: 255 FHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTV 307
+ K+ +GH +++ +S + G+ LL+GS D+T R+WD Q+ QC++ +
Sbjct: 332 AATRKCIAKL-EGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVL 383
Score = 56.6 bits (135), Expect = 4e-08
Identities = 37/138 (26%), Positives = 67/138 (48%), Gaps = 14/138 (10%)
Query: 171 HALPITDLHCGFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDVSIM-AVTMDLAEHH 229
H LP+T++ G T S D+T KLW+ +SGE L ++ +++ A+ +
Sbjct: 91 HILPLTNVALNKSGSC--FITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGD 148
Query: 230 MFCGGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSH 289
GS F W + + +H F+GH ++ CLS + +++ +GS
Sbjct: 149 KIATGS----FDKTCKLWSVETGKCYH-------TFRGHTAEIVCLSFNPQSTLVATGSM 197
Query: 290 DETVRLWDVQSKQCIRTV 307
D T +LWD+Q+ + + T+
Sbjct: 198 DTTAKLWDIQNGEEVYTL 215
Score = 37.4 bits (85), Expect = 0.027
Identities = 16/45 (35%), Positives = 28/45 (62%)
Query: 263 KVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTV 307
KV K H +T ++++ GS ++GS+D T +LWD S + + T+
Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTL 130
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 74.7 bits (182), Expect = 2e-13
Identities = 63/220 (28%), Positives = 99/220 (45%), Gaps = 27/220 (12%)
Query: 81 GPVTCLTASPNGLYVLAGVAE-SIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISG 139
GPV + SP+ Y+L+ + ++ LW + T LV H V QF+ +F+SG
Sbjct: 544 GPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSG 603
Query: 140 GKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLAR-VATSSLDQTV 198
G D + +W+ P +++ H + D++C P + VAT S D+TV
Sbjct: 604 GHDRVARLWATDHY---------QPLRIFAGH---LADVNCTRFHPNSNYVATGSADRTV 651
Query: 199 KLWEVSSGELL-LSVLFDVSIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHP 257
+LW+V +G + + I ++T + G ++G + D+ E
Sbjct: 652 RLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGE----- 706
Query: 258 EQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWD 297
KGH + V L S DG +L SGS D TVRLWD
Sbjct: 707 -------LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 51.6 bits (122), Expect = 1e-06
Identities = 53/214 (24%), Positives = 80/214 (37%), Gaps = 32/214 (14%)
Query: 121 YQDVSCLQFTGDSSHFISGGKDCLVLVWS-----LCSVLQA------DPSRIPAPRHVWS 169
YQ ++ + T DSS G D V VWS L SV QA D +
Sbjct: 470 YQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMD 529
Query: 170 HHALPITDLHCGFGGPLARVA---------TSSLDQTVKLWEVSSGELLLSVLFDVSIMA 220
+ G GP+ + +SS D TV+LW + + L+ +
Sbjct: 530 EKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVW 589
Query: 221 VTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTD 280
T + F G + ++ W + ++F GH V C +
Sbjct: 590 DTQFSPYGYYFVSGGHDRVARL----WATDHYQPL-------RIFAGHLADVNCTRFHPN 638
Query: 281 GSVLLSGSHDETVRLWDVQSKQCIRT-VALKGPV 313
+ + +GS D TVRLWDV + C+R KGP+
Sbjct: 639 SNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPI 672
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 68.9 bits (167), Expect = 8e-12
Identities = 68/247 (27%), Positives = 102/247 (41%), Gaps = 32/247 (12%)
Query: 69 RKDQLQQKIMC----PGPVTCLTASPNGLYVL-AGVAESIHLWEV-STGNLLVILSRHYQ 122
R LQ IM G V C PNG + AG I LW V + L H
Sbjct: 51 RCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSG 110
Query: 123 DVSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLHCGF 182
V L + D S S D V VW D + + H + + +
Sbjct: 111 AVMELHYNTDGSMLFSASTDKTVAVW--------DSETGERVKRLKGHTSF-VNSCYPAR 161
Query: 183 GGPLARVATSSLDQTVKLWEVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGSEGSIFQV 242
GP V T S D TVKLW++ + + ++AVT + + GG +
Sbjct: 162 RGPQL-VCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDN----- 215
Query: 243 DLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQ--- 299
D+ W ++ + + +GH + VT LS+S++GS LLS + D TVR+WDV+
Sbjct: 216 DIKVWDLRQNKLTY-------TMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFA 268
Query: 300 -SKQCIR 305
++C++
Sbjct: 269 PKERCVK 275
Score = 44.7 bits (104), Expect = 2e-04
Identities = 39/195 (20%), Positives = 85/195 (43%), Gaps = 23/195 (11%)
Query: 114 LVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHAL 173
+++LS H +V C +F + S S G D L+L+W++ D + H+
Sbjct: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNV----YGDCDNYATLKG----HSG 110
Query: 174 PITDLHCGFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDVSIMAVTMDLAEH-HMFC 232
+ +LH G + + ++S D+TV +W+ +GE + + S + + C
Sbjct: 111 AVMELHYNTDGSM--LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVC 168
Query: 233 GGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDET 292
GS+ ++ W +++ + Q+ QV ++ + ++SG D
Sbjct: 169 TGSDDGTVKL----WDIRKKAAIQTFQNT--------YQVLAVTFNDTSDQIISGGIDND 216
Query: 293 VRLWDVQSKQCIRTV 307
+++WD++ + T+
Sbjct: 217 IKVWDLRQNKLTYTM 231
Score = 33.9 bits (76), Expect = 0.29
Identities = 32/131 (24%), Positives = 59/131 (45%), Gaps = 11/131 (8%)
Query: 22 VWELHSGANLLTYRGGQAGPRGLALLN-GEYLLAAQLGKNYISAWELQRKDQLQQKI-MC 79
VW+L T RG GL+L + G YLL+ + N + W+++ ++ + +
Sbjct: 219 VWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMD-NTVRVWDVRPFAPKERCVKIF 277
Query: 80 PGPV-------TCLTASPNGLYVLAGVAES-IHLWEVSTGNLLVILSRHYQDVSCLQFTG 131
G V + SP+G + AG A+ +++W+ ++ +L L H ++ + F
Sbjct: 278 QGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHP 337
Query: 132 DSSHFISGGKD 142
D IS D
Sbjct: 338 DEPIIISASSD 348
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 67.0 bits (162), Expect = 3e-11
Identities = 52/221 (23%), Positives = 97/221 (43%), Gaps = 24/221 (10%)
Query: 88 ASPNGLYVLAGVAESIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLV 147
+S + V A +++ LW+V +G L L H V C F S+ ISG D V +
Sbjct: 92 SSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKI 151
Query: 148 WSLCSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKLWEVSSGE 207
W + + S H+ P++ +H G L + + S D ++W+ +SG+
Sbjct: 152 WEV---------KTGKCLKTLSAHSDPVSAVHFNCSGSL--IVSGSYDGLCRIWDAASGQ 200
Query: 208 LLLSVLFDVSIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKG 267
L +++ D + + + + + + L W R R K + G
Sbjct: 201 CLKTLVDDDNPPVSFVKFSPNGKYI---LTATLDNTLKLWDYSRGRCL-------KTYTG 250
Query: 268 HRNQVTCLSVS---TDGSVLLSGSHDETVRLWDVQSKQCIR 305
H+N+ C+ + T G ++SGS D V +W++Q+K+ ++
Sbjct: 251 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ 291
Score = 58.2 bits (139), Expect = 1e-08
Identities = 43/188 (22%), Positives = 87/188 (46%), Gaps = 22/188 (11%)
Query: 120 HYQDVSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLH 179
H + VS ++F+ + S D L+++W + ++ H+ L I+D+
Sbjct: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYE--------KTLYGHN-LEISDV- 89
Query: 180 CGFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGSEGSI 239
+ +R+ ++S D+T+KLW+V SG+ L ++ + + ++ GS
Sbjct: 90 -AWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGS---- 144
Query: 240 FQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQ 299
F + W + + K H + V+ + + GS+++SGS+D R+WD
Sbjct: 145 FDETVKIWEVKTGKCL-------KTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAA 197
Query: 300 SKQCIRTV 307
S QC++T+
Sbjct: 198 SGQCLKTL 205
Score = 56.2 bits (134), Expect = 6e-08
Identities = 53/233 (22%), Positives = 96/233 (41%), Gaps = 38/233 (16%)
Query: 83 VTCLTASPNGLYVLAGVAES-IHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGK 141
V+ + SPNG ++ + A+ I +W G L H ++S + ++ DSS +S
Sbjct: 44 VSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASD 103
Query: 142 DCLVLVWSLCS-----VLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQ 196
D + +W + S L+ + + C F P + + S D+
Sbjct: 104 DKTLKLWDVRSGKCLKTLKGHSNYV----------------FCCNFNPPSNLIISGSFDE 147
Query: 197 TVKLWEVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGS---EGSIFQVDLFTWPGQRER 253
TVK+WEV +G+ L ++ A + ++ H C GS GS + W +
Sbjct: 148 TVKIWEVKTGKCL------KTLSAHSDPVSAVHFNCSGSLIVSGS-YDGLCRIWDAASGQ 200
Query: 254 SFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRT 306
D V+ + S +G +L+ + D T++LWD +C++T
Sbjct: 201 CLKTLVD------DDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKT 247
Score = 44.7 bits (104), Expect = 2e-04
Identities = 21/49 (42%), Positives = 35/49 (71%), Gaps = 2/49 (4%)
Query: 263 KVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTVALKG 311
K GH +++ ++ S+D S L+S S D+T++LWDV+S +C++T LKG
Sbjct: 77 KTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKT--LKG 123
>gi|118402582 cell division cycle 20 [Homo sapiens]
Length = 499
Score = 66.2 bits (160), Expect = 5e-11
Identities = 73/296 (24%), Positives = 123/296 (41%), Gaps = 29/296 (9%)
Query: 7 VAVCTDSAAPMWSCIVWELHSGANLLTYRGGQAGP--RGLALLNGEYLLAAQLGKNYISA 64
+AV D++ +WS SG L + Q G +A + LA +
Sbjct: 198 LAVALDNSVYLWSA-----SSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQL 252
Query: 65 WELQRKDQLQQKIMCPGPVTCLTASPNGLYVLAGVAES--IHLWEVSTG-NLLVILSRHY 121
W++Q++ +L+ V L+ + Y+L+ + S IH +V + + LS H
Sbjct: 253 WDVQQQKRLRNMTSHSARVGSLSWNS---YILSSGSRSGHIHHHDVRVAEHHVATLSGHS 309
Query: 122 QDVSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLH-C 180
Q+V L++ D H SGG D LV VW A P ++ H + + C
Sbjct: 310 QEVCGLRWAPDGRHLASGGNDNLVNVWP-----SAPGEGGWVPLQTFTQHQGAVKAVAWC 364
Query: 181 GFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGSEGSIF 240
+ + + D+ +++W V SG L +V D ++ + H+ G
Sbjct: 365 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAV--DAHSQVCSILWSPHYKELISGHG-FA 421
Query: 241 QVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLW 296
Q L W +P KGH ++V L++S DG+ + S + DET+RLW
Sbjct: 422 QNQLVIWK-------YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 66.2 bits (160), Expect = 5e-11
Identities = 61/230 (26%), Positives = 98/230 (42%), Gaps = 18/230 (7%)
Query: 83 VTCLTASPNGLYVLAGVAESIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGKD 142
V C + + A +++ W++ TG LL + VSC +F+ D + +SG
Sbjct: 149 VECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSC-KFSPDGKYVVSG--- 204
Query: 143 CLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKLWE 202
+ +C + D I + HH IT C F RVA+ SLD+ +K+W+
Sbjct: 205 -FDVDHGICIM---DAENITTVSVIKDHHTRSITS--CCFDPDSQRVASVSLDRCIKIWD 258
Query: 203 VSSGELLLSVLFDVS-IMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDA 261
V+S LL++ S ++ H C S + +L W F
Sbjct: 259 VTSQATLLTITKAHSNAISNCCFTFSGHFLCTSS----WDKNLKIW-NVHTGEFRNCGAC 313
Query: 262 GKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTVALKG 311
+ +GH V+ + D S L+SG D TV +WDV + R ++LKG
Sbjct: 314 VTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDV--AEGYRKLSLKG 361
Score = 60.5 bits (145), Expect = 3e-09
Identities = 49/192 (25%), Positives = 76/192 (39%), Gaps = 20/192 (10%)
Query: 116 ILSRHYQDVSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPI 175
ILS H VS F D + +SG DC V +W DP R P+
Sbjct: 97 ILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLW--------DPVDGSVVRDFEHRPKAPV 148
Query: 176 TDLHCGFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGS 235
+ C G +RV +S D+TV+ W++ +G+LL V +D I++ ++ G
Sbjct: 149 VE--CSITGDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSG-- 204
Query: 236 EGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRL 295
F VD G + H +T D + S S D +++
Sbjct: 205 ----FDVD----HGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKI 256
Query: 296 WDVQSKQCIRTV 307
WDV S+ + T+
Sbjct: 257 WDVTSQATLLTI 268
Score = 38.1 bits (87), Expect = 0.016
Identities = 21/58 (36%), Positives = 29/58 (50%), Gaps = 2/58 (3%)
Query: 263 KVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTV--ALKGPVTNAAI 318
K+ GH + V+ D + LLSGS+D TV+LWD +R K PV +I
Sbjct: 96 KILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSI 153
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 65.9 bits (159), Expect = 7e-11
Identities = 52/211 (24%), Positives = 104/211 (49%), Gaps = 37/211 (17%)
Query: 102 SIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLVW-----SLCSVLQA 156
++ +W++ TG L +L H V C+Q+ D +SG D +V VW + LQ
Sbjct: 364 TLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQG 421
Query: 157 DPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDV 216
+R+ ++L +H V + SLD ++++W+V +G + ++
Sbjct: 422 HTNRV---------YSLQFDGIH---------VVSGSLDTSIRVWDVETGNCIHTLTGHQ 463
Query: 217 SIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLS 276
S+ + M+L ++ + G ++ ++ D+ T GQ ++ Q K H++ VTCL
Sbjct: 464 SLTS-GMELKDNILVSGNADSTVKIWDIKT--GQCLQTL---QGPNK----HQSAVTCLQ 513
Query: 277 VSTDGSVLLSGSHDETVRLWDVQSKQCIRTV 307
+ + +++ S D TV+LWD+++ + IR +
Sbjct: 514 FNKN--FVITSSDDGTVKLWDLKTGEFIRNL 542
Score = 52.4 bits (124), Expect = 8e-07
Identities = 47/222 (21%), Positives = 90/222 (40%), Gaps = 32/222 (14%)
Query: 91 NGLYVLAGVAESIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLVWSL 150
+ + + ++ +W TG + L H V C+ +SG +D + VW +
Sbjct: 313 DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDI 370
Query: 151 CSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKLWEVSSGELLL 210
HV H + + + G RV + + D VK+W+ + E L
Sbjct: 371 ---------ETGQCLHVLMGHVAAVRCVQ--YDG--RRVVSGAYDFMVKVWDPET-ETCL 416
Query: 211 SVLFDVSIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRN 270
L + ++ H+ G + SI W + H GH++
Sbjct: 417 HTLQGHTNRVYSLQFDGIHVVSGSLDTSIR-----VWDVETGNCIH-------TLTGHQS 464
Query: 271 QVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTVALKGP 312
+ + + + +L+SG+ D TV++WD+++ QC++T L+GP
Sbjct: 465 LTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQT--LQGP 502
Score = 45.4 bits (106), Expect = 1e-04
Identities = 35/128 (27%), Positives = 61/128 (47%), Gaps = 21/128 (16%)
Query: 91 NGLYVLAGVAE-SIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLVWS 149
+G++V++G + SI +W+V TGN + L+ H S ++ + +SG D V +W
Sbjct: 432 DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWD 489
Query: 150 L----CSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKLWEVSS 205
+ C P++ H +T L V TSS D TVKLW++ +
Sbjct: 490 IKTGQCLQTLQGPNK----------HQSAVTCLQFNKNF----VITSSDDGTVKLWDLKT 535
Query: 206 GELLLSVL 213
GE + +++
Sbjct: 536 GEFIRNLV 543
Score = 43.5 bits (101), Expect = 4e-04
Identities = 35/148 (23%), Positives = 64/148 (43%), Gaps = 21/148 (14%)
Query: 161 IPAPRHVWSHHALPITDLH-CGFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDVSIM 219
+ +P+ + H IT L CG R+ + S D T+K+W +G+ L +++
Sbjct: 252 LKSPKVLKGHDDHVITCLQFCG-----NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTG-- 304
Query: 220 AVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVST 279
V ++ GS +V W + H GH + V C+ +
Sbjct: 305 GVWSSQMRDNIIISGSTDRTLKV----WNAETGECIH-------TLYGHTSTVRCMHLHE 353
Query: 280 DGSVLLSGSHDETVRLWDVQSKQCIRTV 307
++SGS D T+R+WD+++ QC+ +
Sbjct: 354 --KRVVSGSRDATLRVWDIETGQCLHVL 379
Score = 38.9 bits (89), Expect = 0.009
Identities = 20/51 (39%), Positives = 32/51 (62%), Gaps = 3/51 (5%)
Query: 258 EQDAGKVFKGHRNQV-TCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTV 307
E + KV KGH + V TCL G+ ++SGS D T+++W + +C+RT+
Sbjct: 251 ELKSPKVLKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTL 299
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 65.9 bits (159), Expect = 7e-11
Identities = 52/211 (24%), Positives = 104/211 (49%), Gaps = 37/211 (17%)
Query: 102 SIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLVW-----SLCSVLQA 156
++ +W++ TG L +L H V C+Q+ D +SG D +V VW + LQ
Sbjct: 482 TLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQG 539
Query: 157 DPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDV 216
+R+ ++L +H V + SLD ++++W+V +G + ++
Sbjct: 540 HTNRV---------YSLQFDGIH---------VVSGSLDTSIRVWDVETGNCIHTLTGHQ 581
Query: 217 SIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLS 276
S+ + M+L ++ + G ++ ++ D+ T GQ ++ Q K H++ VTCL
Sbjct: 582 SLTS-GMELKDNILVSGNADSTVKIWDIKT--GQCLQTL---QGPNK----HQSAVTCLQ 631
Query: 277 VSTDGSVLLSGSHDETVRLWDVQSKQCIRTV 307
+ + +++ S D TV+LWD+++ + IR +
Sbjct: 632 FNKN--FVITSSDDGTVKLWDLKTGEFIRNL 660
Score = 52.4 bits (124), Expect = 8e-07
Identities = 47/222 (21%), Positives = 90/222 (40%), Gaps = 32/222 (14%)
Query: 91 NGLYVLAGVAESIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLVWSL 150
+ + + ++ +W TG + L H V C+ +SG +D + VW +
Sbjct: 431 DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDI 488
Query: 151 CSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKLWEVSSGELLL 210
HV H + + + G RV + + D VK+W+ + E L
Sbjct: 489 ---------ETGQCLHVLMGHVAAVRCVQ--YDG--RRVVSGAYDFMVKVWDPET-ETCL 534
Query: 211 SVLFDVSIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRN 270
L + ++ H+ G + SI W + H GH++
Sbjct: 535 HTLQGHTNRVYSLQFDGIHVVSGSLDTSIR-----VWDVETGNCIH-------TLTGHQS 582
Query: 271 QVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTVALKGP 312
+ + + + +L+SG+ D TV++WD+++ QC++T L+GP
Sbjct: 583 LTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQT--LQGP 620
Score = 45.4 bits (106), Expect = 1e-04
Identities = 35/128 (27%), Positives = 61/128 (47%), Gaps = 21/128 (16%)
Query: 91 NGLYVLAGVAE-SIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLVWS 149
+G++V++G + SI +W+V TGN + L+ H S ++ + +SG D V +W
Sbjct: 550 DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWD 607
Query: 150 L----CSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKLWEVSS 205
+ C P++ H +T L V TSS D TVKLW++ +
Sbjct: 608 IKTGQCLQTLQGPNK----------HQSAVTCLQFNKNF----VITSSDDGTVKLWDLKT 653
Query: 206 GELLLSVL 213
GE + +++
Sbjct: 654 GEFIRNLV 661
Score = 43.5 bits (101), Expect = 4e-04
Identities = 35/148 (23%), Positives = 64/148 (43%), Gaps = 21/148 (14%)
Query: 161 IPAPRHVWSHHALPITDLH-CGFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDVSIM 219
+ +P+ + H IT L CG R+ + S D T+K+W +G+ L +++
Sbjct: 370 LKSPKVLKGHDDHVITCLQFCG-----NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTG-- 422
Query: 220 AVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVST 279
V ++ GS +V W + H GH + V C+ +
Sbjct: 423 GVWSSQMRDNIIISGSTDRTLKV----WNAETGECIH-------TLYGHTSTVRCMHLHE 471
Query: 280 DGSVLLSGSHDETVRLWDVQSKQCIRTV 307
++SGS D T+R+WD+++ QC+ +
Sbjct: 472 --KRVVSGSRDATLRVWDIETGQCLHVL 497
Score = 38.9 bits (89), Expect = 0.009
Identities = 20/51 (39%), Positives = 32/51 (62%), Gaps = 3/51 (5%)
Query: 258 EQDAGKVFKGHRNQV-TCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTV 307
E + KV KGH + V TCL G+ ++SGS D T+++W + +C+RT+
Sbjct: 369 ELKSPKVLKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTL 417
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 65.9 bits (159), Expect = 7e-11
Identities = 52/211 (24%), Positives = 104/211 (49%), Gaps = 37/211 (17%)
Query: 102 SIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLVW-----SLCSVLQA 156
++ +W++ TG L +L H V C+Q+ D +SG D +V VW + LQ
Sbjct: 402 TLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQG 459
Query: 157 DPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDV 216
+R+ ++L +H V + SLD ++++W+V +G + ++
Sbjct: 460 HTNRV---------YSLQFDGIH---------VVSGSLDTSIRVWDVETGNCIHTLTGHQ 501
Query: 217 SIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLS 276
S+ + M+L ++ + G ++ ++ D+ T GQ ++ Q K H++ VTCL
Sbjct: 502 SLTS-GMELKDNILVSGNADSTVKIWDIKT--GQCLQTL---QGPNK----HQSAVTCLQ 551
Query: 277 VSTDGSVLLSGSHDETVRLWDVQSKQCIRTV 307
+ + +++ S D TV+LWD+++ + IR +
Sbjct: 552 FNKN--FVITSSDDGTVKLWDLKTGEFIRNL 580
Score = 52.4 bits (124), Expect = 8e-07
Identities = 47/222 (21%), Positives = 90/222 (40%), Gaps = 32/222 (14%)
Query: 91 NGLYVLAGVAESIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLVWSL 150
+ + + ++ +W TG + L H V C+ +SG +D + VW +
Sbjct: 351 DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDI 408
Query: 151 CSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKLWEVSSGELLL 210
HV H + + + G RV + + D VK+W+ + E L
Sbjct: 409 ---------ETGQCLHVLMGHVAAVRCVQ--YDG--RRVVSGAYDFMVKVWDPET-ETCL 454
Query: 211 SVLFDVSIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRN 270
L + ++ H+ G + SI W + H GH++
Sbjct: 455 HTLQGHTNRVYSLQFDGIHVVSGSLDTSIR-----VWDVETGNCIH-------TLTGHQS 502
Query: 271 QVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTVALKGP 312
+ + + + +L+SG+ D TV++WD+++ QC++T L+GP
Sbjct: 503 LTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQT--LQGP 540
Score = 45.4 bits (106), Expect = 1e-04
Identities = 35/128 (27%), Positives = 61/128 (47%), Gaps = 21/128 (16%)
Query: 91 NGLYVLAGVAE-SIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLVWS 149
+G++V++G + SI +W+V TGN + L+ H S ++ + +SG D V +W
Sbjct: 470 DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWD 527
Query: 150 L----CSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKLWEVSS 205
+ C P++ H +T L V TSS D TVKLW++ +
Sbjct: 528 IKTGQCLQTLQGPNK----------HQSAVTCLQFNKNF----VITSSDDGTVKLWDLKT 573
Query: 206 GELLLSVL 213
GE + +++
Sbjct: 574 GEFIRNLV 581
Score = 43.5 bits (101), Expect = 4e-04
Identities = 35/148 (23%), Positives = 64/148 (43%), Gaps = 21/148 (14%)
Query: 161 IPAPRHVWSHHALPITDLH-CGFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDVSIM 219
+ +P+ + H IT L CG R+ + S D T+K+W +G+ L +++
Sbjct: 290 LKSPKVLKGHDDHVITCLQFCG-----NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTG-- 342
Query: 220 AVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVST 279
V ++ GS +V W + H GH + V C+ +
Sbjct: 343 GVWSSQMRDNIIISGSTDRTLKV----WNAETGECIH-------TLYGHTSTVRCMHLHE 391
Query: 280 DGSVLLSGSHDETVRLWDVQSKQCIRTV 307
++SGS D T+R+WD+++ QC+ +
Sbjct: 392 --KRVVSGSRDATLRVWDIETGQCLHVL 417
Score = 38.9 bits (89), Expect = 0.009
Identities = 20/51 (39%), Positives = 32/51 (62%), Gaps = 3/51 (5%)
Query: 258 EQDAGKVFKGHRNQV-TCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTV 307
E + KV KGH + V TCL G+ ++SGS D T+++W + +C+RT+
Sbjct: 289 ELKSPKVLKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTL 337
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 65.5 bits (158), Expect = 9e-11
Identities = 59/250 (23%), Positives = 99/250 (39%), Gaps = 33/250 (13%)
Query: 74 QQKIMCPGPVTCLTASPNGLYVLAGVAESIHLWEVSTGNLLVILSRHYQDVSCLQFTGDS 133
+ +++C C ++ + V + + +W TG L+ H + V+C FT S
Sbjct: 657 EDEVLC-----CAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSS 711
Query: 134 SHFI--SGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVAT 191
H + +G DC + +W L R+ H + HC F +A+
Sbjct: 712 HHLLLATGSSDCFLKLWDL---------NQKECRNTMFGHTNSVN--HCRFSPDDKLLAS 760
Query: 192 SSLDQTVKLWEVSSGELLLSV---LFDVSIMAVTMDLAEHHMFCGGS-EGSIFQV----D 243
S D T+KLW+ +S S+ F +++ D+ C S +G+ V
Sbjct: 761 CSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK 820
Query: 244 LFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQC 303
+F W +GH + V + S DGS L+ S D+T+RLW+ +
Sbjct: 821 IFLWNTDSRSKVAD-------CRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCK 873
Query: 304 IRTVALKGPV 313
V LK V
Sbjct: 874 NSAVMLKQEV 883
Score = 45.4 bits (106), Expect = 1e-04
Identities = 48/234 (20%), Positives = 91/234 (38%), Gaps = 39/234 (16%)
Query: 83 VTCLTASPNGLYVLAGVAE-SIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGK 141
V+C SP+ Y+ G +I + E+ + +H + V +QFT D IS
Sbjct: 921 VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSD 980
Query: 142 DCLVLVWSL----CSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQT 197
D + VW+ C L+ + R + + +R+ + S D T
Sbjct: 981 DAEIQVWNWQLDKCIFLRGHQETVKDFRLLKN-----------------SRLLSWSFDGT 1023
Query: 198 VKLWEVSSGELLLS-VLFDVSIMA--VTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERS 254
VK+W + +G V ++++ ++ D + I+ DL
Sbjct: 1024 VKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLL-------- 1075
Query: 255 FHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTVA 308
P + +GH V C + S D ++L +G + +R+W+V + + + A
Sbjct: 1076 --PLHE----LRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCA 1123
Score = 39.3 bits (90), Expect = 0.007
Identities = 62/297 (20%), Positives = 112/297 (37%), Gaps = 60/297 (20%)
Query: 52 LLAAQLGKNYISAWELQRKDQLQQKIMCPGPVTCLTASPNGLYVLAGVAE-SIHLWEVST 110
LLA ++ W+L +K+ V SP+ + + A+ ++ LW+ ++
Sbjct: 715 LLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATS 774
Query: 111 GN---------LLVILSRHYQD----VSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQAD 157
N + L +D V C ++ D + + K+ + L W+ S +
Sbjct: 775 ANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFL-WNTDSRSKVA 833
Query: 158 PSRIPAPRHV-WSHHALPITDLHCGFGGPLARVATSSLDQTVKLWEVS----SGELLLSV 212
R H+ W H + F + TSS DQT++LWE + ++L
Sbjct: 834 DCR----GHLSWVHGVM--------FSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQ 881
Query: 213 LFDV-----SIMAVTMDLAEHHMFCGGSEGSIFQVDLFTW---------PGQRERSFHPE 258
DV +M + +D G G Q+D T P + +F E
Sbjct: 882 EVDVVFQENEVMVLAVDHIRRLQLINGRTG---QIDYLTEAQVSCCCLSPHLQYIAFGDE 938
Query: 259 QDA--------GKVFKG---HRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCI 304
A ++F+ H+ V + + D L+S S D +++W+ Q +CI
Sbjct: 939 NGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI 995
Score = 32.0 bits (71), Expect = 1.1
Identities = 12/41 (29%), Positives = 24/41 (58%)
Query: 266 KGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRT 306
K H ++V C + STD + + S D+ V++W+ + + + T
Sbjct: 654 KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHT 694
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 65.5 bits (158), Expect = 9e-11
Identities = 59/250 (23%), Positives = 99/250 (39%), Gaps = 33/250 (13%)
Query: 74 QQKIMCPGPVTCLTASPNGLYVLAGVAESIHLWEVSTGNLLVILSRHYQDVSCLQFTGDS 133
+ +++C C ++ + V + + +W TG L+ H + V+C FT S
Sbjct: 646 EDEVLC-----CAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSS 700
Query: 134 SHFI--SGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVAT 191
H + +G DC + +W L R+ H + HC F +A+
Sbjct: 701 HHLLLATGSSDCFLKLWDL---------NQKECRNTMFGHTNSVN--HCRFSPDDKLLAS 749
Query: 192 SSLDQTVKLWEVSSGELLLSV---LFDVSIMAVTMDLAEHHMFCGGS-EGSIFQV----D 243
S D T+KLW+ +S S+ F +++ D+ C S +G+ V
Sbjct: 750 CSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK 809
Query: 244 LFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQC 303
+F W +GH + V + S DGS L+ S D+T+RLW+ +
Sbjct: 810 IFLWNTDSRSKVAD-------CRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCK 862
Query: 304 IRTVALKGPV 313
V LK V
Sbjct: 863 NSAVMLKQEV 872
Score = 45.4 bits (106), Expect = 1e-04
Identities = 48/234 (20%), Positives = 91/234 (38%), Gaps = 39/234 (16%)
Query: 83 VTCLTASPNGLYVLAGVAE-SIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGK 141
V+C SP+ Y+ G +I + E+ + +H + V +QFT D IS
Sbjct: 910 VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSD 969
Query: 142 DCLVLVWSL----CSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQT 197
D + VW+ C L+ + R + + +R+ + S D T
Sbjct: 970 DAEIQVWNWQLDKCIFLRGHQETVKDFRLLKN-----------------SRLLSWSFDGT 1012
Query: 198 VKLWEVSSGELLLS-VLFDVSIMA--VTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERS 254
VK+W + +G V ++++ ++ D + I+ DL
Sbjct: 1013 VKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLL-------- 1064
Query: 255 FHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTVA 308
P + +GH V C + S D ++L +G + +R+W+V + + + A
Sbjct: 1065 --PLHE----LRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCA 1112
Score = 39.3 bits (90), Expect = 0.007
Identities = 62/297 (20%), Positives = 112/297 (37%), Gaps = 60/297 (20%)
Query: 52 LLAAQLGKNYISAWELQRKDQLQQKIMCPGPVTCLTASPNGLYVLAGVAE-SIHLWEVST 110
LLA ++ W+L +K+ V SP+ + + A+ ++ LW+ ++
Sbjct: 704 LLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATS 763
Query: 111 GN---------LLVILSRHYQD----VSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQAD 157
N + L +D V C ++ D + + K+ + L W+ S +
Sbjct: 764 ANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFL-WNTDSRSKVA 822
Query: 158 PSRIPAPRHV-WSHHALPITDLHCGFGGPLARVATSSLDQTVKLWEVS----SGELLLSV 212
R H+ W H + F + TSS DQT++LWE + ++L
Sbjct: 823 DCR----GHLSWVHGVM--------FSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQ 870
Query: 213 LFDV-----SIMAVTMDLAEHHMFCGGSEGSIFQVDLFTW---------PGQRERSFHPE 258
DV +M + +D G G Q+D T P + +F E
Sbjct: 871 EVDVVFQENEVMVLAVDHIRRLQLINGRTG---QIDYLTEAQVSCCCLSPHLQYIAFGDE 927
Query: 259 QDA--------GKVFKG---HRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCI 304
A ++F+ H+ V + + D L+S S D +++W+ Q +CI
Sbjct: 928 NGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI 984
Score = 32.0 bits (71), Expect = 1.1
Identities = 12/41 (29%), Positives = 24/41 (58%)
Query: 266 KGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRT 306
K H ++V C + STD + + S D+ V++W+ + + + T
Sbjct: 643 KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHT 683
>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
sapiens]
Length = 421
Score = 65.5 bits (158), Expect = 9e-11
Identities = 64/260 (24%), Positives = 110/260 (42%), Gaps = 34/260 (13%)
Query: 50 EYLLAAQLGKNYISAWELQRKDQLQQKIMCPGPVTCLTASPNGLYVLAGVA--ESIHLWE 107
+ LLA L I W++ L + V LT +P+G +L + +++ +W+
Sbjct: 140 QLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWD 199
Query: 108 VST-GNLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQADPSRIPAPRH 166
+ GN++ +L H V F+ DSS S G V +W++ + R
Sbjct: 200 LKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNM--------DKYTMIRK 251
Query: 167 VWSHHALPITDLHCGFGGPLARVATSSLDQTVKLWEVSSGELLLSV--LFDVSIMAVTMD 224
+ HH + C F A +AT+S D V +W+ +G++L+ LF
Sbjct: 252 LEGHHHDVVA---CDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFP--------- 299
Query: 225 LAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDA--GKVFKGHRNQVT------CLS 276
+F GG+ + F+ G S ++ ++ + + QV C +
Sbjct: 300 -PPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCA 358
Query: 277 VSTDGSVLLSGSHDETVRLW 296
STDGSVL +G+HD +V W
Sbjct: 359 FSTDGSVLAAGTHDGSVYFW 378
Score = 43.9 bits (102), Expect = 3e-04
Identities = 45/164 (27%), Positives = 69/164 (42%), Gaps = 18/164 (10%)
Query: 142 DCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKLW 201
DC +VWSL A S +P + + I FG +AT + +K+W
Sbjct: 105 DCGDIVWSL-----AFGSSVPEKQS----RCVNIEWHRFRFGQDQLLLATGLNNGRIKIW 155
Query: 202 EVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDA 261
+V +G+LLL++ V V DL +GS+ V R + +
Sbjct: 156 DVYTGKLLLNL---VDHTEVVRDLTF------APDGSLILVSASRDKTLRVWDLKDDGNM 206
Query: 262 GKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIR 305
KV +GH+N V + S D S+L S + V LW++ IR
Sbjct: 207 MKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIR 250
Score = 34.7 bits (78), Expect = 0.17
Identities = 29/129 (22%), Positives = 56/129 (43%), Gaps = 15/129 (11%)
Query: 171 HALPITDLHCGFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDVSIMAVTMDLA-EHH 229
H + DL G L V+ S D+T+++W++ ++ VL + + +
Sbjct: 169 HTEVVRDLTFAPDGSLILVSASR-DKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSS 227
Query: 230 MFCG-GSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGS 288
M C G+ ++F ++ + R+ +GH + V S DG++L + S
Sbjct: 228 MLCSVGASKAVFLWNMDKYTMIRK------------LEGHHHDVVACDFSPDGALLATAS 275
Query: 289 HDETVRLWD 297
+D V +WD
Sbjct: 276 YDTRVYIWD 284
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 64.7 bits (156), Expect = 2e-10
Identities = 61/288 (21%), Positives = 104/288 (36%), Gaps = 67/288 (23%)
Query: 22 VWELHSGANLLTYRGGQAGPRGLALLNGEYLLAAQLGKNYISAWELQRKDQLQQKIMCPG 81
+W + G T G + G +A + LL + + W++ L+
Sbjct: 71 IWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN 130
Query: 82 PVTCLTASPNGLYVLAG-VAESIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGG 140
V C +P +++G ES+ +W+V TG L L H VS + F D S +S
Sbjct: 131 YVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSS 190
Query: 141 KDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKL 200
D L +W D + + + P++ + G AT LD T+KL
Sbjct: 191 YDGLCRIW--------DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT--LDNTLKL 240
Query: 201 WEVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQD 260
W+ S G+ L
Sbjct: 241 WDYSKGKCL--------------------------------------------------- 249
Query: 261 AGKVFKGHRNQVTCLSVS---TDGSVLLSGSHDETVRLWDVQSKQCIR 305
K + GH+N+ C+ + T G ++SGS D V +W++Q+K+ ++
Sbjct: 250 --KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ 295
Score = 57.8 bits (138), Expect = 2e-08
Identities = 46/191 (24%), Positives = 87/191 (45%), Gaps = 22/191 (11%)
Query: 117 LSRHYQDVSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPIT 176
L+ H + VS ++F+ + S D L+ +W A + S H L I+
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG------AYDGKF---EKTISGHKLGIS 91
Query: 177 DLHCGFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGSE 236
D+ L + ++S D+T+K+W+VSSG+ L ++ + + + ++ GS
Sbjct: 92 DVAWSSDSNL--LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGS- 148
Query: 237 GSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLW 296
F + W + + K H + V+ + + DGS+++S S+D R+W
Sbjct: 149 ---FDESVRIWDVKTGKCL-------KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Query: 297 DVQSKQCIRTV 307
D S QC++T+
Sbjct: 199 DTASGQCLKTL 209
Score = 50.1 bits (118), Expect = 4e-06
Identities = 44/225 (19%), Positives = 95/225 (42%), Gaps = 22/225 (9%)
Query: 83 VTCLTASPNGLYVLAGVAES-IHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGK 141
V+ + SPNG ++ + A+ I +W G +S H +S + ++ DS+ +S
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 107
Query: 142 DCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKLW 201
D + +W D S + + H C F + + S D++V++W
Sbjct: 108 DKTLKIW--------DVSSGKCLKTLKGHSNYVFC---CNFNPQSNLIVSGSFDESVRIW 156
Query: 202 EVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDA 261
+V +G+ L ++ ++ + + S + ++ T GQ ++ + +
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRI-WDTASGQCLKTLIDDDNP 215
Query: 262 GKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRT 306
V+ + S +G +L+ + D T++LWD +C++T
Sbjct: 216 ---------PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 251
Score = 43.9 bits (102), Expect = 3e-04
Identities = 19/49 (38%), Positives = 35/49 (71%), Gaps = 2/49 (4%)
Query: 263 KVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTVALKG 311
K GH+ ++ ++ S+D ++L+S S D+T+++WDV S +C++T LKG
Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKT--LKG 127
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 64.7 bits (156), Expect = 2e-10
Identities = 61/288 (21%), Positives = 104/288 (36%), Gaps = 67/288 (23%)
Query: 22 VWELHSGANLLTYRGGQAGPRGLALLNGEYLLAAQLGKNYISAWELQRKDQLQQKIMCPG 81
+W + G T G + G +A + LL + + W++ L+
Sbjct: 71 IWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN 130
Query: 82 PVTCLTASPNGLYVLAG-VAESIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGG 140
V C +P +++G ES+ +W+V TG L L H VS + F D S +S
Sbjct: 131 YVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSS 190
Query: 141 KDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKL 200
D L +W D + + + P++ + G AT LD T+KL
Sbjct: 191 YDGLCRIW--------DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT--LDNTLKL 240
Query: 201 WEVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQD 260
W+ S G+ L
Sbjct: 241 WDYSKGKCL--------------------------------------------------- 249
Query: 261 AGKVFKGHRNQVTCLSVS---TDGSVLLSGSHDETVRLWDVQSKQCIR 305
K + GH+N+ C+ + T G ++SGS D V +W++Q+K+ ++
Sbjct: 250 --KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ 295
Score = 57.8 bits (138), Expect = 2e-08
Identities = 46/191 (24%), Positives = 87/191 (45%), Gaps = 22/191 (11%)
Query: 117 LSRHYQDVSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPIT 176
L+ H + VS ++F+ + S D L+ +W A + S H L I+
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG------AYDGKF---EKTISGHKLGIS 91
Query: 177 DLHCGFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGSE 236
D+ L + ++S D+T+K+W+VSSG+ L ++ + + + ++ GS
Sbjct: 92 DVAWSSDSNL--LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGS- 148
Query: 237 GSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLW 296
F + W + + K H + V+ + + DGS+++S S+D R+W
Sbjct: 149 ---FDESVRIWDVKTGKCL-------KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Query: 297 DVQSKQCIRTV 307
D S QC++T+
Sbjct: 199 DTASGQCLKTL 209
Score = 50.1 bits (118), Expect = 4e-06
Identities = 44/225 (19%), Positives = 95/225 (42%), Gaps = 22/225 (9%)
Query: 83 VTCLTASPNGLYVLAGVAES-IHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGK 141
V+ + SPNG ++ + A+ I +W G +S H +S + ++ DS+ +S
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 107
Query: 142 DCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKLW 201
D + +W D S + + H C F + + S D++V++W
Sbjct: 108 DKTLKIW--------DVSSGKCLKTLKGHSNYVFC---CNFNPQSNLIVSGSFDESVRIW 156
Query: 202 EVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDA 261
+V +G+ L ++ ++ + + S + ++ T GQ ++ + +
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRI-WDTASGQCLKTLIDDDNP 215
Query: 262 GKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRT 306
V+ + S +G +L+ + D T++LWD +C++T
Sbjct: 216 ---------PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 251
Score = 43.9 bits (102), Expect = 3e-04
Identities = 19/49 (38%), Positives = 35/49 (71%), Gaps = 2/49 (4%)
Query: 263 KVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTVALKG 311
K GH+ ++ ++ S+D ++L+S S D+T+++WDV S +C++T LKG
Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKT--LKG 127
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 63.2 bits (152), Expect = 5e-10
Identities = 61/252 (24%), Positives = 105/252 (41%), Gaps = 51/252 (20%)
Query: 81 GPVTCLTASPNGLYVLAGVAE-SIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISG 139
G V C+ P + + G A+ +I +W++++G L + L+ H V + + S + S
Sbjct: 205 GWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSC 264
Query: 140 GKDCLVLVWSL------------------------------CS---VLQADPSRIPAPRH 166
G+D V W L CS + R A H
Sbjct: 265 GEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVH 324
Query: 167 VWSHHALPITDLHCGFGGPLARVATSSLDQTVKLWEVSSGELLLSVL-FDVSIMAVTMDL 225
S H + + C P ++ T S D T++LW++ +G+ +++ S+ AV +
Sbjct: 325 TLSGHTNAVATVRCQAAEP--QIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLH- 381
Query: 226 AEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLL 285
H+ F GS +I Q W P+ + GH + L+V++DG VL+
Sbjct: 382 PRHYTFASGSPDNIKQ-----WK-------FPDGSFIQNLSGHNAIINTLTVNSDG-VLV 428
Query: 286 SGSHDETVRLWD 297
SG+ + T+ LWD
Sbjct: 429 SGADNGTMHLWD 440
Score = 50.8 bits (120), Expect = 2e-06
Identities = 34/119 (28%), Positives = 61/119 (51%), Gaps = 13/119 (10%)
Query: 191 TSSLDQTVKLWEVSSGELLLSVLFDVS-IMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPG 249
T S D+T+K+W+++SG+L LS+ +S + V + ++F G + + DL
Sbjct: 221 TGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEY--N 278
Query: 250 QRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTVA 308
+ R +H GH + V L + VL++ S D T R+WDV++K + T++
Sbjct: 279 KVIRHYH----------GHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLS 327
Score = 38.9 bits (89), Expect = 0.009
Identities = 16/53 (30%), Positives = 27/53 (50%)
Query: 248 PGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQS 300
P + +HP +V GH V C++V ++GS D T+++WD+ S
Sbjct: 183 PTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLAS 235
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 62.4 bits (150), Expect = 8e-10
Identities = 66/255 (25%), Positives = 105/255 (41%), Gaps = 31/255 (12%)
Query: 62 ISAWELQRKDQLQQKIMCPGPVTCLTASPNG-LYVLAGVAESIHLWEVSTGNLLVILSRH 120
+ WE + L + GPV SP+G L+ A ++ LW+V+ L +L H
Sbjct: 45 VYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGH 104
Query: 121 YQDVSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLHC 180
+ V + F+ DS SGG D V++W V R+ V ++ +D
Sbjct: 105 QRSVETVSFSPDSRQLASGGWDKRVMLW---DVQSGQMLRL----LVGHRDSIQSSD--- 154
Query: 181 GFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGSEGSIF 240
F + +AT S D TV +W+ L V VS A+ A C + G +
Sbjct: 155 -FSPTVNCLATGSWDSTVHIWD------LRMVTPAVSHQALEGHSANISCLCYSASGLLA 207
Query: 241 QVDLFTWPGQRERSFH---PEQDAGKV-FKGHRNQVTCLSVSTDGSVLLSGSHDETVRLW 296
G +++ H P + + KGH V ++ S D L S + V++W
Sbjct: 208 S-------GSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVW 260
Query: 297 DVQSKQCIRTVALKG 311
D + +C+ T LKG
Sbjct: 261 DCNTGKCLET--LKG 273
Score = 48.5 bits (114), Expect = 1e-05
Identities = 42/144 (29%), Positives = 59/144 (40%), Gaps = 22/144 (15%)
Query: 191 TSSLDQTVKLWEVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQ 250
T S D V WE SG+LL + + + H+F S ++ W
Sbjct: 38 TGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRL----WDVA 93
Query: 251 RERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTVALK 310
R + +V KGH+ V +S S D L SG D+ V LWDVQS Q +R +
Sbjct: 94 RAKCL-------RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGH 146
Query: 311 GPVTNAAILLAPVSMLSSDFRPSL 334
S+ SSDF P++
Sbjct: 147 RD-----------SIQSSDFSPTV 159
Score = 33.5 bits (75), Expect = 0.38
Identities = 20/52 (38%), Positives = 27/52 (51%), Gaps = 1/52 (1%)
Query: 263 KVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCI-RTVALKGPV 313
K F H +V + S DG +LL+GS D V W+ +S Q + R GPV
Sbjct: 15 KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPV 66
Score = 29.6 bits (65), Expect = 5.6
Identities = 29/127 (22%), Positives = 52/127 (40%), Gaps = 9/127 (7%)
Query: 22 VWELHSGANLLTYRGGQAGPRGLALL--NGEYLLAAQLGKNYISAWELQRKDQLQQKIMC 79
+W+L ++++ + ++ L + LLA+ I W+ L I
Sbjct: 173 IWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLL---IQL 229
Query: 80 PGPVTCLTA---SPNGLYVL-AGVAESIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSH 135
G VT + + SP+ L++ AG + + +W+ +TG L L FT D
Sbjct: 230 KGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKI 289
Query: 136 FISGGKD 142
+SG D
Sbjct: 290 LVSGAAD 296
>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
isoform a [Homo sapiens]
Length = 353
Score = 59.7 bits (143), Expect = 5e-09
Identities = 68/251 (27%), Positives = 104/251 (41%), Gaps = 66/251 (26%)
Query: 60 NYISAWELQRKDQLQQKIMCPGPVTCLTASPNGLYVLAGVAESIHLWEVSTGNLLVILSR 119
NY+SA D + LTAS +G + LW+V +G LL
Sbjct: 154 NYLSACSFTNSD-----------MQILTASGDG---------TCALWDVESGQLLQSFHG 193
Query: 120 HYQDVSCLQF----TGDSSHFISGGKDCLVLVWSLCS-----VLQADPSRIPAPRHVWSH 170
H DV CL TG++ F+SGG D +VW + S + S I + R+ S
Sbjct: 194 HGADVLCLDLAPSETGNT--FVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSG 251
Query: 171 HALPITDLHCGFGGPLARVATSSLDQTVKLWEVSSGELLL-----SVLFDVSIMAVTMDL 225
A A+ S D T +L+++ + + S++F S +V L
Sbjct: 252 DAF----------------ASGSDDATCRLYDLRADREVAIYSKESIIFGAS--SVDFSL 293
Query: 226 AEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLL 285
+ +F G ++ +I D+ G R + GH N+V+ L VS DG+
Sbjct: 294 SGRLLFAGYNDYTINVWDVLK--GSRV----------SILFGHENRVSTLRVSPDGTAFC 341
Query: 286 SGSHDETVRLW 296
SGS D T+R+W
Sbjct: 342 SGSWDHTLRVW 352
Score = 42.0 bits (97), Expect = 0.001
Identities = 38/194 (19%), Positives = 77/194 (39%), Gaps = 24/194 (12%)
Query: 117 LSRHYQDVSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPIT 176
L H V C+ + D +S +D V+VW + + +P W
Sbjct: 59 LKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPC---TWV------- 108
Query: 177 DLHCGFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGSE 236
+ C + +A LD ++ ++ + + ++ A +A H +
Sbjct: 109 -MACAYAPSGCAIACGGLDNKCSVYPLTFDK-------NENMAAKKKSVAMHTNYLSACS 160
Query: 237 GSIFQVDLFTWPGQRERSFHPEQDAGKV---FKGHRNQVTCLSV--STDGSVLLSGSHDE 291
+ + + T G + + ++G++ F GH V CL + S G+ +SG D+
Sbjct: 161 FTNSDMQILTASGDGTCALW-DVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDK 219
Query: 292 TVRLWDVQSKQCIR 305
+WD++S QC++
Sbjct: 220 KAMVWDMRSGQCVQ 233
Score = 38.9 bits (89), Expect = 0.009
Identities = 32/124 (25%), Positives = 52/124 (41%), Gaps = 15/124 (12%)
Query: 180 CGFGGPLARVATSSLDQTVKLWEVSSGELLLSVL---FDVSIMAVTMDLAEHHMFCGGSE 236
C F ++ T+S D T LW+V SG+LL S DV + + + GG +
Sbjct: 159 CSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCD 218
Query: 237 GSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLW 296
D+ + GQ + F+ H + + + G SGS D T RL+
Sbjct: 219 KKAMVWDMRS--GQ----------CVQAFETHESDINSVRYYPSGDAFASGSDDATCRLY 266
Query: 297 DVQS 300
D+++
Sbjct: 267 DLRA 270
Score = 30.8 bits (68), Expect = 2.5
Identities = 13/35 (37%), Positives = 19/35 (54%)
Query: 263 KVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWD 297
+ KGH N+V C+ D ++S S D V +WD
Sbjct: 57 RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWD 91
Score = 30.0 bits (66), Expect = 4.3
Identities = 13/39 (33%), Positives = 22/39 (56%)
Query: 268 HRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRT 306
H N ++ S + +L+ S D T LWDV+S Q +++
Sbjct: 152 HTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQS 190
>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
isoform b [Homo sapiens]
Length = 395
Score = 59.7 bits (143), Expect = 5e-09
Identities = 68/251 (27%), Positives = 104/251 (41%), Gaps = 66/251 (26%)
Query: 60 NYISAWELQRKDQLQQKIMCPGPVTCLTASPNGLYVLAGVAESIHLWEVSTGNLLVILSR 119
NY+SA D + LTAS +G + LW+V +G LL
Sbjct: 196 NYLSACSFTNSD-----------MQILTASGDG---------TCALWDVESGQLLQSFHG 235
Query: 120 HYQDVSCLQF----TGDSSHFISGGKDCLVLVWSLCS-----VLQADPSRIPAPRHVWSH 170
H DV CL TG++ F+SGG D +VW + S + S I + R+ S
Sbjct: 236 HGADVLCLDLAPSETGNT--FVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSG 293
Query: 171 HALPITDLHCGFGGPLARVATSSLDQTVKLWEVSSGELLL-----SVLFDVSIMAVTMDL 225
A A+ S D T +L+++ + + S++F S +V L
Sbjct: 294 DAF----------------ASGSDDATCRLYDLRADREVAIYSKESIIFGAS--SVDFSL 335
Query: 226 AEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLL 285
+ +F G ++ +I D+ G R + GH N+V+ L VS DG+
Sbjct: 336 SGRLLFAGYNDYTINVWDVLK--GSRV----------SILFGHENRVSTLRVSPDGTAFC 383
Query: 286 SGSHDETVRLW 296
SGS D T+R+W
Sbjct: 384 SGSWDHTLRVW 394
Score = 42.0 bits (97), Expect = 0.001
Identities = 38/194 (19%), Positives = 77/194 (39%), Gaps = 24/194 (12%)
Query: 117 LSRHYQDVSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPIT 176
L H V C+ + D +S +D V+VW + + +P W
Sbjct: 101 LKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPC---TWV------- 150
Query: 177 DLHCGFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGSE 236
+ C + +A LD ++ ++ + + ++ A +A H +
Sbjct: 151 -MACAYAPSGCAIACGGLDNKCSVYPLTFDK-------NENMAAKKKSVAMHTNYLSACS 202
Query: 237 GSIFQVDLFTWPGQRERSFHPEQDAGKV---FKGHRNQVTCLSV--STDGSVLLSGSHDE 291
+ + + T G + + ++G++ F GH V CL + S G+ +SG D+
Sbjct: 203 FTNSDMQILTASGDGTCALW-DVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDK 261
Query: 292 TVRLWDVQSKQCIR 305
+WD++S QC++
Sbjct: 262 KAMVWDMRSGQCVQ 275
Score = 38.9 bits (89), Expect = 0.009
Identities = 32/124 (25%), Positives = 52/124 (41%), Gaps = 15/124 (12%)
Query: 180 CGFGGPLARVATSSLDQTVKLWEVSSGELLLSVL---FDVSIMAVTMDLAEHHMFCGGSE 236
C F ++ T+S D T LW+V SG+LL S DV + + + GG +
Sbjct: 201 CSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCD 260
Query: 237 GSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLW 296
D+ + GQ + F+ H + + + G SGS D T RL+
Sbjct: 261 KKAMVWDMRS--GQ----------CVQAFETHESDINSVRYYPSGDAFASGSDDATCRLY 308
Query: 297 DVQS 300
D+++
Sbjct: 309 DLRA 312
Score = 30.8 bits (68), Expect = 2.5
Identities = 13/35 (37%), Positives = 19/35 (54%)
Query: 263 KVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWD 297
+ KGH N+V C+ D ++S S D V +WD
Sbjct: 99 RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWD 133
Score = 30.0 bits (66), Expect = 4.3
Identities = 13/39 (33%), Positives = 22/39 (56%)
Query: 268 HRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRT 306
H N ++ S + +L+ S D T LWDV+S Q +++
Sbjct: 194 HTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQS 232
>gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo
sapiens]
Length = 275
Score = 59.7 bits (143), Expect = 5e-09
Identities = 56/224 (25%), Positives = 98/224 (43%), Gaps = 34/224 (15%)
Query: 86 LTASPNGLYVLAGVA--ESIHLWEVST-GNLLVILSRHYQDVSCLQFTGDSSHFISGGKD 142
LT +P+G +L + +++ +W++ GN++ +L H V F+ DSS S G
Sbjct: 30 LTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGAS 89
Query: 143 CLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKLWE 202
V +W++ + R + HH + C F A +AT+S D V +W+
Sbjct: 90 KAVFLWNM--------DKYTMIRKLEGHHHDVVA---CDFSPDGALLATASYDTRVYIWD 138
Query: 203 VSSGELLLSV--LFDVSIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQD 260
+G++L+ LF +F GG+ + F+ G S ++
Sbjct: 139 PHNGDILMEFGHLFP----------PPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKM 188
Query: 261 A--GKVFKGHRNQVT------CLSVSTDGSVLLSGSHDETVRLW 296
++ + + QV C + STDGSVL +G+HD +V W
Sbjct: 189 VRFWRIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 232
Score = 34.7 bits (78), Expect = 0.17
Identities = 29/129 (22%), Positives = 56/129 (43%), Gaps = 15/129 (11%)
Query: 171 HALPITDLHCGFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDVSIMAVTMDLA-EHH 229
H + DL G L V+ S D+T+++W++ ++ VL + + +
Sbjct: 23 HTEVVRDLTFAPDGSLILVSASR-DKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSS 81
Query: 230 MFCG-GSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGS 288
M C G+ ++F ++ + R+ +GH + V S DG++L + S
Sbjct: 82 MLCSVGASKAVFLWNMDKYTMIRK------------LEGHHHDVVACDFSPDGALLATAS 129
Query: 289 HDETVRLWD 297
+D V +WD
Sbjct: 130 YDTRVYIWD 138
Score = 32.0 bits (71), Expect = 1.1
Identities = 20/53 (37%), Positives = 32/53 (60%), Gaps = 7/53 (13%)
Query: 254 SFHP---EQDAGKVFKG---HRNQVTCLSVSTDGS-VLLSGSHDETVRLWDVQ 299
SF P E++ GK+ H V L+ + DGS +L+S S D+T+R+WD++
Sbjct: 3 SFPPRVNEKEIGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLK 55
Score = 31.6 bits (70), Expect = 1.5
Identities = 16/43 (37%), Positives = 23/43 (53%)
Query: 263 KVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIR 305
KV +GH+N V + S D S+L S + V LW++ IR
Sbjct: 62 KVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIR 104
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 59.3 bits (142), Expect = 7e-09
Identities = 37/128 (28%), Positives = 60/128 (46%), Gaps = 15/128 (11%)
Query: 171 HALPITDLHCGFGGPLARVATSSLDQTVKLWEVSSGELLLSVL-FDVSIMAVTMDLAEHH 229
H LP+ + G L +AT S D+ VK+W + G+ S+ D S+M + H
Sbjct: 590 HKLPVICMDISHDGAL--IATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHL 647
Query: 230 MFCGGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSH 289
F G + I Q W + + +GH ++ CL+VS G ++S SH
Sbjct: 648 FFTAGKDHKIKQ-----WDADKFEHI-------QTLEGHHQEIWCLAVSPSGDYVVSSSH 695
Query: 290 DETVRLWD 297
D+++RLW+
Sbjct: 696 DKSLRLWE 703
Score = 55.8 bits (133), Expect = 7e-08
Identities = 51/209 (24%), Positives = 90/209 (43%), Gaps = 26/209 (12%)
Query: 92 GLYVLAGVAESIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLVWSLC 151
G YV E + +W++ G ++IL Q+V+CL + D H G +D + ++SL
Sbjct: 36 GRYVAVPACEHVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLL 95
Query: 152 SVLQADPSRIPAPRHVWSHHALPITDL-HCGFGGPLARVATSSLDQTVKLWEVSSGELLL 210
S ++ H IT L + GG R+A+ S D + +W+V + L
Sbjct: 96 S---------GEGNVTFNGHKAAITTLKYDQLGG---RLASGSKDTDIIVWDVINESGLY 143
Query: 211 SVLFDVSIMAVTMDLAEHHMF-CGGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHR 269
+ + + L E ++ G + + DL T Q K GHR
Sbjct: 144 RLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDT------------QHCFKTMVGHR 191
Query: 270 NQVTCLSVSTDGSVLLSGSHDETVRLWDV 298
+V L + ++ L++G+ D +R+WD+
Sbjct: 192 TEVWGLVLLSEEKRLITGASDSELRVWDI 220
Score = 44.3 bits (103), Expect = 2e-04
Identities = 35/131 (26%), Positives = 58/131 (44%), Gaps = 14/131 (10%)
Query: 82 PVTCLTASPNGLYVLAGVAE-SIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGG 140
PV C+ S +G + G A+ ++ +W + G+ L H V LQF S F + G
Sbjct: 593 PVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAG 652
Query: 141 KDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLA-RVATSSLDQTVK 199
KD + W D + + + HH ++ C P V +SS D++++
Sbjct: 653 KDHKIKQW--------DADKFEHIQTLEGHH----QEIWCLAVSPSGDYVVSSSHDKSLR 700
Query: 200 LWEVSSGELLL 210
LWE + L+L
Sbjct: 701 LWERTREPLIL 711
Score = 41.6 bits (96), Expect = 0.001
Identities = 40/206 (19%), Positives = 79/206 (38%), Gaps = 55/206 (26%)
Query: 103 IHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQADPSRIP 162
+ L+++++GNLL + H + + + D F++GG D V W V + ++
Sbjct: 478 LQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKR 537
Query: 163 APRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKLWEVSSGELLLSV-LFDVSIMAV 221
+ + T LD+ V S + LL+V L D ++
Sbjct: 538 LS---------------------VKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIF 576
Query: 222 TMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDG 281
+D + F + L+ GH+ V C+ +S DG
Sbjct: 577 YVDTLK------------FFLSLY---------------------GHKLPVICMDISHDG 603
Query: 282 SVLLSGSHDETVRLWDVQSKQCIRTV 307
+++ +GS D V++W + C +++
Sbjct: 604 ALIATGSADRNVKIWGLDFGDCHKSL 629
Score = 37.4 bits (85), Expect = 0.027
Identities = 17/41 (41%), Positives = 28/41 (68%), Gaps = 1/41 (2%)
Query: 267 GHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTV 307
GHR+ V LS S+D +LS + D ++++W+ + QCIRT+
Sbjct: 413 GHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTM 452
Score = 32.7 bits (73), Expect = 0.66
Identities = 29/147 (19%), Positives = 56/147 (38%), Gaps = 1/147 (0%)
Query: 22 VWELHSGANLLTYRGGQAGPRGLALLNGEYLLAAQLGKNYISAWELQRKDQLQQKIMCPG 81
++ L SG +T+ G +A L LA+ I W++ + L +
Sbjct: 91 IFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKD 150
Query: 82 PVT-CLTASPNGLYVLAGVAESIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGG 140
+T L L V +G + W++ T + + H +V L + I+G
Sbjct: 151 AITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGA 210
Query: 141 KDCLVLVWSLCSVLQADPSRIPAPRHV 167
D + VW + + + + P P+ +
Sbjct: 211 SDSELRVWDIAYLQEIEDPEEPDPKKI 237
Score = 30.0 bits (66), Expect = 4.3
Identities = 17/69 (24%), Positives = 32/69 (46%), Gaps = 1/69 (1%)
Query: 83 VTCLTASPNGLYVLAGVAE-SIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGK 141
V C++ SPN + + + ++ ++ V T + L H V C+ + D + +G
Sbjct: 552 VLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSA 611
Query: 142 DCLVLVWSL 150
D V +W L
Sbjct: 612 DRNVKIWGL 620
Score = 29.3 bits (64), Expect = 7.3
Identities = 13/37 (35%), Positives = 22/37 (59%)
Query: 264 VFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQS 300
+ +G + +VTCL S DG L G D ++R++ + S
Sbjct: 60 ILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLS 96
>gi|89886480 zinedin isoform 2 [Homo sapiens]
Length = 760
Score = 58.9 bits (141), Expect = 9e-09
Identities = 72/310 (23%), Positives = 114/310 (36%), Gaps = 60/310 (19%)
Query: 33 TYRGGQAGPRGLALLNGEYLLAAQLGKNYISAWELQRKDQLQQKIMCP-----------G 81
T R G R LA + + L + W LQ+ ++ G
Sbjct: 440 TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRG 499
Query: 82 PVTCLTASPNGLYVLAGVAES-IHLWEV-----------STGNLLVILSRHYQDVSCLQF 129
PV + N Y +G A++ IH W++ L +L H V L F
Sbjct: 500 PVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAF 559
Query: 130 TGDSSHFISGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARV 189
+ S S D V +W S A P S H +P + V
Sbjct: 560 SPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTA----SEHGVPTS------------V 603
Query: 190 ATSSLDQTVKLWEVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPG 249
A +S + + SG+ +VL+D+ + + + L GS G + + P
Sbjct: 604 AFTSTEPAHIVASFRSGD---TVLYDMEVGSALLTLESR-----GSSGPTQINQVVSHPN 655
Query: 250 QRERSFHPEQDAGKVFK------------GHRNQVTCLSVSTDGSVLLSGSHDETVRLWD 297
Q + D G F H + VTCL+V +G+ L+SGSHD ++RLW
Sbjct: 656 Q-PLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS 714
Query: 298 VQSKQCIRTV 307
+ +K C++ +
Sbjct: 715 LDNKTCVQEI 724
>gi|89886477 zinedin isoform 1 [Homo sapiens]
Length = 753
Score = 58.9 bits (141), Expect = 9e-09
Identities = 72/310 (23%), Positives = 114/310 (36%), Gaps = 60/310 (19%)
Query: 33 TYRGGQAGPRGLALLNGEYLLAAQLGKNYISAWELQRKDQLQQKIMCP-----------G 81
T R G R LA + + L + W LQ+ ++ G
Sbjct: 433 TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRG 492
Query: 82 PVTCLTASPNGLYVLAGVAES-IHLWEV-----------STGNLLVILSRHYQDVSCLQF 129
PV + N Y +G A++ IH W++ L +L H V L F
Sbjct: 493 PVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAF 552
Query: 130 TGDSSHFISGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARV 189
+ S S D V +W S A P S H +P + V
Sbjct: 553 SPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTA----SEHGVPTS------------V 596
Query: 190 ATSSLDQTVKLWEVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPG 249
A +S + + SG+ +VL+D+ + + + L GS G + + P
Sbjct: 597 AFTSTEPAHIVASFRSGD---TVLYDMEVGSALLTLESR-----GSSGPTQINQVVSHPN 648
Query: 250 QRERSFHPEQDAGKVFK------------GHRNQVTCLSVSTDGSVLLSGSHDETVRLWD 297
Q + D G F H + VTCL+V +G+ L+SGSHD ++RLW
Sbjct: 649 Q-PLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS 707
Query: 298 VQSKQCIRTV 307
+ +K C++ +
Sbjct: 708 LDNKTCVQEI 717
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 58.9 bits (141), Expect = 9e-09
Identities = 53/203 (26%), Positives = 91/203 (44%), Gaps = 34/203 (16%)
Query: 117 LSRHYQD----VSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHA 172
L RH++ V+C+ F+ ++ SG D ++VW + +A + ++ H
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA---------YRFTGHK 61
Query: 173 LPITDLHCGFGGPLARVATSSLDQTVKLWEVS-SGELLLSVLFDVSIMAVTMDLAEHHMF 231
+T ++ G L +A+ S D+TV++W + GE S +F A T + H F
Sbjct: 62 DAVTCVNFSPSGHL--LASGSRDKTVRIWVPNVKGE---STVF----RAHTATVRSVH-F 111
Query: 232 CGGSEGSIFQVDLFT---WPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGS 288
C + + D T W R++ H N V C S DG +++S S
Sbjct: 112 CSDGQSFVTASDDKTVKVWATHRQKFLFS-------LSQHINWVRCAKFSPDGRLIVSAS 164
Query: 289 HDETVRLWDVQSKQCIRTVALKG 311
D+TV+LWD S++C+ + G
Sbjct: 165 DDKTVKLWDKSSRECVHSYCEHG 187
Score = 54.3 bits (129), Expect = 2e-07
Identities = 46/204 (22%), Positives = 83/204 (40%), Gaps = 24/204 (11%)
Query: 94 YVLAGVAESIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLVWSLCSV 153
+V A +++ +W L LS+H V C +F+ D +S D V +W S
Sbjct: 118 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSS- 176
Query: 154 LQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKLWEVSSGELLLSV- 212
H + H +T + F +A + +D TVK+W+V + LL
Sbjct: 177 --------RECVHSYCEHGGFVT--YVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQ 226
Query: 213 LFDVSIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQV 272
L ++ ++ + +++ S+ ++ +DL G+ + H GH+
Sbjct: 227 LHSAAVNGLSFHPSGNYLITASSDSTLKILDLM--EGRLLYTLH----------GHQGPA 274
Query: 273 TCLSVSTDGSVLLSGSHDETVRLW 296
T ++ S G SG DE V +W
Sbjct: 275 TTVAFSRTGEYFASGGSDEQVMVW 298
Score = 50.8 bits (120), Expect = 2e-06
Identities = 46/235 (19%), Positives = 89/235 (37%), Gaps = 25/235 (10%)
Query: 83 VTCLTASPNGLYVLAGVAES-IHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGK 141
VTC+ S N + +G +S + +W + + + H V+C+ F+ SG +
Sbjct: 22 VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
Query: 142 DCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLH-CGFGGPLARVATSSLDQTVKL 200
D V +W + V+ H + +H C G T+S D+TVK+
Sbjct: 82 DKTVRIWV---------PNVKGESTVFRAHTATVRSVHFCSDGQSFV---TASDDKTVKV 129
Query: 201 WEVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQD 260
W + L S+ ++ + + + S+ ++ W H
Sbjct: 130 WATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKL----WDKSSRECVHS--- 182
Query: 261 AGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTVALKGPVTN 315
+ H VT + G+ + + D TV++WDV++ + ++ L N
Sbjct: 183 ----YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN 233
Score = 44.7 bits (104), Expect = 2e-04
Identities = 29/115 (25%), Positives = 55/115 (47%), Gaps = 3/115 (2%)
Query: 53 LAAQLGKNYISAWELQRKDQLQQKIMCPGPVTCLTASPNGLYVLAGVAES-IHLWEVSTG 111
+AA N + W+++ LQ + V L+ P+G Y++ ++S + + ++ G
Sbjct: 202 IAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEG 261
Query: 112 NLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLVW--SLCSVLQADPSRIPAP 164
LL L H + + F+ +F SGG D V+VW + V + +++P P
Sbjct: 262 RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRP 316
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 58.9 bits (141), Expect = 9e-09
Identities = 53/203 (26%), Positives = 91/203 (44%), Gaps = 34/203 (16%)
Query: 117 LSRHYQD----VSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHA 172
L RH++ V+C+ F+ ++ SG D ++VW + +A + ++ H
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA---------YRFTGHK 61
Query: 173 LPITDLHCGFGGPLARVATSSLDQTVKLWEVS-SGELLLSVLFDVSIMAVTMDLAEHHMF 231
+T ++ G L +A+ S D+TV++W + GE S +F A T + H F
Sbjct: 62 DAVTCVNFSPSGHL--LASGSRDKTVRIWVPNVKGE---STVF----RAHTATVRSVH-F 111
Query: 232 CGGSEGSIFQVDLFT---WPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGS 288
C + + D T W R++ H N V C S DG +++S S
Sbjct: 112 CSDGQSFVTASDDKTVKVWATHRQKFLFS-------LSQHINWVRCAKFSPDGRLIVSAS 164
Query: 289 HDETVRLWDVQSKQCIRTVALKG 311
D+TV+LWD S++C+ + G
Sbjct: 165 DDKTVKLWDKSSRECVHSYCEHG 187
Score = 54.3 bits (129), Expect = 2e-07
Identities = 46/204 (22%), Positives = 83/204 (40%), Gaps = 24/204 (11%)
Query: 94 YVLAGVAESIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLVWSLCSV 153
+V A +++ +W L LS+H V C +F+ D +S D V +W S
Sbjct: 118 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSS- 176
Query: 154 LQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKLWEVSSGELLLSV- 212
H + H +T + F +A + +D TVK+W+V + LL
Sbjct: 177 --------RECVHSYCEHGGFVT--YVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQ 226
Query: 213 LFDVSIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQV 272
L ++ ++ + +++ S+ ++ +DL G+ + H GH+
Sbjct: 227 LHSAAVNGLSFHPSGNYLITASSDSTLKILDLM--EGRLLYTLH----------GHQGPA 274
Query: 273 TCLSVSTDGSVLLSGSHDETVRLW 296
T ++ S G SG DE V +W
Sbjct: 275 TTVAFSRTGEYFASGGSDEQVMVW 298
Score = 50.8 bits (120), Expect = 2e-06
Identities = 46/235 (19%), Positives = 89/235 (37%), Gaps = 25/235 (10%)
Query: 83 VTCLTASPNGLYVLAGVAES-IHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGK 141
VTC+ S N + +G +S + +W + + + H V+C+ F+ SG +
Sbjct: 22 VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
Query: 142 DCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLH-CGFGGPLARVATSSLDQTVKL 200
D V +W + V+ H + +H C G T+S D+TVK+
Sbjct: 82 DKTVRIWV---------PNVKGESTVFRAHTATVRSVHFCSDGQSFV---TASDDKTVKV 129
Query: 201 WEVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQD 260
W + L S+ ++ + + + S+ ++ W H
Sbjct: 130 WATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKL----WDKSSRECVHS--- 182
Query: 261 AGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTVALKGPVTN 315
+ H VT + G+ + + D TV++WDV++ + ++ L N
Sbjct: 183 ----YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN 233
Score = 44.7 bits (104), Expect = 2e-04
Identities = 29/115 (25%), Positives = 55/115 (47%), Gaps = 3/115 (2%)
Query: 53 LAAQLGKNYISAWELQRKDQLQQKIMCPGPVTCLTASPNGLYVLAGVAES-IHLWEVSTG 111
+AA N + W+++ LQ + V L+ P+G Y++ ++S + + ++ G
Sbjct: 202 IAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEG 261
Query: 112 NLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLVW--SLCSVLQADPSRIPAP 164
LL L H + + F+ +F SGG D V+VW + V + +++P P
Sbjct: 262 RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRP 316
>gi|4759276 RNA, U3 small nucleolar interacting protein 2 [Homo
sapiens]
Length = 475
Score = 58.2 bits (139), Expect = 1e-08
Identities = 49/233 (21%), Positives = 101/233 (43%), Gaps = 38/233 (16%)
Query: 83 VTCLTASPNGLYVLAGVAE-SIHLWEVSTGNLLVILSR-----------HYQDVSCLQFT 130
+TCL +P+ + + + SI W V +G L ++ R H V C+ +
Sbjct: 149 ITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMAIS 208
Query: 131 GDSSHFISGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVA 190
D + SG + L+L+W S + ++ H ++ L F ++
Sbjct: 209 SDGKYLASGDRSKLILIWEAQSCQHL---------YTFTGHRDAVSGL--AFRRGTHQLY 257
Query: 191 TSSLDQTVKLWEVSSGELLLSVLFDVSIMAVTMDLA-EHHMFCGGSEGSIFQVDLFTWPG 249
++S D++VK+W V+ + ++ +A L+ E + GG +G++
Sbjct: 258 STSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTV---------- 307
Query: 250 QRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQ 302
R + +++ VF GH+ + C+ + + ++SG+ D +V LW + K+
Sbjct: 308 ---RVWKIPEESQLVFYGHQGSIDCIHLINE-EHMVSGADDGSVALWGLSKKR 356
Score = 55.8 bits (133), Expect = 7e-08
Identities = 50/211 (23%), Positives = 83/211 (39%), Gaps = 25/211 (11%)
Query: 21 IVWELHSGANLLTYRGGQAGPRGLALLNGEYLLAAQLGKNYISAWELQRKDQLQQKIMCP 80
++WE S +L T+ G + GLA G + L + + W + ++
Sbjct: 224 LIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQ 283
Query: 81 GPVTCLTASPNGLYVLAGVAE-SIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISG 139
V L A V AG + ++ +W++ + LV H + C+ + H +SG
Sbjct: 284 DAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYG-HQGSIDCIHLINE-EHMVSG 341
Query: 140 GKDCLVLVWSLCSV-----------LQADPSRIPAPRHVWSHHALPITDLHCGFGGPLAR 188
D V +W L L+ +P + P + S AL TDL
Sbjct: 342 ADDGSVALWGLSKKRPLALQREAHGLRGEPG-LEQPFWISSVAALLNTDL---------- 390
Query: 189 VATSSLDQTVKLWEVSSGELLLSVLFDVSIM 219
VAT S V+LW+ G L +L D+ ++
Sbjct: 391 VATGSHSSCVRLWQCGEGFRQLDLLCDIPLV 421
Score = 45.1 bits (105), Expect = 1e-04
Identities = 51/220 (23%), Positives = 90/220 (40%), Gaps = 24/220 (10%)
Query: 83 VTCLTASPNGLYVLAGV-AESIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGK 141
V C+ S +G Y+ +G ++ I +WE + L + H VS L F + S
Sbjct: 202 VLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSH 261
Query: 142 DCLVLVWSLCSVLQADPSRIPAP-RHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKL 200
D V VW++ A+ S + H + AL C V D TV++
Sbjct: 262 DRSVKVWNV-----AENSYVETLFGHQDAVAALDALSRECC-------VTAGGRDGTVRV 309
Query: 201 WEVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQD 260
W++ L+ SI + + + E HM G +GS+ W ++R +++
Sbjct: 310 WKIPEESQLVFYGHQGSIDCIHL-INEEHMVSGADDGSVA-----LWGLSKKRPLALQRE 363
Query: 261 A----GKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLW 296
A G+ ++ ++ + ++ +GSH VRLW
Sbjct: 364 AHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLW 403
Score = 40.8 bits (94), Expect = 0.002
Identities = 27/95 (28%), Positives = 45/95 (47%), Gaps = 11/95 (11%)
Query: 216 VSIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFH--PEQDAGKVFK--GHRNQ 271
++ + VT D + +F + SI + W + R H P G K GH +
Sbjct: 149 ITCLVVTPD--DSAIFSAAKDCSIIK-----WSVESGRKLHVIPRAKKGAEGKPPGHSSH 201
Query: 272 VTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRT 306
V C+++S+DG L SG + + +W+ QS Q + T
Sbjct: 202 VLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYT 236
Score = 38.9 bits (89), Expect = 0.009
Identities = 41/148 (27%), Positives = 68/148 (45%), Gaps = 17/148 (11%)
Query: 263 KVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTV--ALKG-----PVTN 315
+V +GH+ +TCL V+ D S + S + D ++ W V+S + + + A KG P +
Sbjct: 140 RVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHS 199
Query: 316 AAILLAPVS----MLSSDFRPSLPL---PHFNKHLLGAEHGDEPRHGGLTLRLGLHQQGS 368
+ +L +S L+S R L L +HL G GL R G HQ S
Sbjct: 200 SHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLY-TFTGHRDAVSGLAFRRGTHQLYS 258
Query: 369 EPSYLDRTEQLQAVLCSTMEKSVLGGQD 396
DR+ ++ V ++ +++ G QD
Sbjct: 259 TSH--DRSVKVWNVAENSYVETLFGHQD 284
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 58.2 bits (139), Expect = 1e-08
Identities = 63/290 (21%), Positives = 120/290 (41%), Gaps = 29/290 (10%)
Query: 22 VWELHSGANLLTYRGGQAGPRGLALLNGEYLLAAQLGKNYISAWELQRKDQLQQKIMCPG 81
VW+ +G T +G + ++ + LLA+ I W+ Q + ++
Sbjct: 134 VWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDH 193
Query: 82 PVTCLTASPNGLYVLAGVAE-SIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGG 140
V+ + PNG ++++ + +I +WEV TG + + H + V ++ D + S
Sbjct: 194 NVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCS 253
Query: 141 KDCLVLVWSL----CSVLQADPSRIP-----APRHVWSHHALPITDLHCGFGGPLARVAT 191
D V VW + C + + AP +S + G P + +
Sbjct: 254 NDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLS 313
Query: 192 SSLDQTVKLWEVSSGELLLSVL-FDVSIMAVTMDLAEHHMFCGGSEGSIFQVD---LFTW 247
S D+T+K+W+VS+G L++++ D + V +F G + + D L W
Sbjct: 314 GSRDKTIKMWDVSTGMCLMTLVGHDNWVRGV--------LFHSGGKFILSCADDKTLRVW 365
Query: 248 PGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWD 297
+ +R K H + VT L +++GS D+TV++W+
Sbjct: 366 DYKNKRCM-------KTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 50.4 bits (119), Expect = 3e-06
Identities = 47/188 (25%), Positives = 81/188 (43%), Gaps = 24/188 (12%)
Query: 117 LSRHYQDVSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPIT 176
LS H V+ + F S +S +D + VW + D R H +
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYET---GDFER------TLKGHTDSVQ 154
Query: 177 DLHCGFGGPLARVATSSLDQTVKLWEVSSGELLLSVL-FDVSIMAVTMDLAEHHMFCGGS 235
D+ G L +A+ S D T+KLW+ E + ++ D ++ +V + H+
Sbjct: 155 DISFDHSGKL--LASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASR 212
Query: 236 EGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRL 295
+ +I ++ T K F GHR V + + DG+++ S S+D+TVR+
Sbjct: 213 DKTIKMWEVQTGY------------CVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRV 260
Query: 296 WDVQSKQC 303
W V +K+C
Sbjct: 261 WVVATKEC 268
Score = 47.4 bits (111), Expect = 3e-05
Identities = 46/206 (22%), Positives = 77/206 (37%), Gaps = 44/206 (21%)
Query: 102 SIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQADPSRI 161
+I LW+ + + H +VS + + H +S +D + +W V +
Sbjct: 173 TIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE---VQTGYCVKT 229
Query: 162 PAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDVSIMAV 221
W P D G L +A+ S DQTV++W V++ E
Sbjct: 230 FTGHREWVRMVRPNQD------GTL--IASCSNDQTVRVWVVATKEC------------- 268
Query: 222 TMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDG 281
+L EH V+ +W + S E + K + G
Sbjct: 269 KAELREHEHV----------VECISWAPESSYSSISEATGSETKKSGK----------PG 308
Query: 282 SVLLSGSHDETVRLWDVQSKQCIRTV 307
LLSGS D+T+++WDV + C+ T+
Sbjct: 309 PFLLSGSRDKTIKMWDVSTGMCLMTL 334
Score = 46.6 bits (109), Expect = 4e-05
Identities = 33/147 (22%), Positives = 73/147 (49%), Gaps = 17/147 (11%)
Query: 162 PAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDV-SIMA 220
P ++ S H P+T + F + + ++S D T+K+W+ +G+ ++ S+
Sbjct: 98 PPEKYALSGHRSPVTRVI--FHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQD 155
Query: 221 VTMDLAEHHMFCGGSEGSIFQVDLFTWPG-QRERSFHPEQDAGKVFKGHRNQVTCLSVST 279
++ D H S + + L+ + G + R+ H GH + V+ +++
Sbjct: 156 ISFD---HSGKLLASCSADMTIKLWDFQGFECIRTMH----------GHDHNVSSVAIMP 202
Query: 280 DGSVLLSGSHDETVRLWDVQSKQCIRT 306
+G ++S S D+T+++W+VQ+ C++T
Sbjct: 203 NGDHIVSASRDKTIKMWEVQTGYCVKT 229
Score = 43.5 bits (101), Expect = 4e-04
Identities = 20/48 (41%), Positives = 28/48 (58%)
Query: 260 DAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTV 307
D + KGH + V +S G +L S S D T++LWD Q +CIRT+
Sbjct: 141 DFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTM 188
Score = 33.1 bits (74), Expect = 0.50
Identities = 18/45 (40%), Positives = 27/45 (60%), Gaps = 2/45 (4%)
Query: 267 GHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTVALKG 311
GHR+ VT + SV++S S D T+++WD ++ RT LKG
Sbjct: 106 GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERT--LKG 148
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 58.2 bits (139), Expect = 1e-08
Identities = 52/223 (23%), Positives = 89/223 (39%), Gaps = 65/223 (29%)
Query: 82 PVTCLTASPNGLYVLAGVAE-SIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGG 140
PV L SP LY +G + + LW L I + H DV C++F +S++ +G
Sbjct: 386 PVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGS 445
Query: 141 KDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKL 200
D V +WS Q + R+ ++ H P+ L G +A++ DQ +KL
Sbjct: 446 TDKTVRLWS---AQQGNSVRL------FTGHRGPVLSLAFSPNGKY--LASAGEDQRLKL 494
Query: 201 WEVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQD 260
W+++S G+++
Sbjct: 495 WDLAS-------------------------------GTLY-------------------- 503
Query: 261 AGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQC 303
K +GH + +T L+ S D ++ S S D +VR+WD+++ C
Sbjct: 504 --KELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYC 544
Score = 52.0 bits (123), Expect = 1e-06
Identities = 60/253 (23%), Positives = 99/253 (39%), Gaps = 39/253 (15%)
Query: 52 LLAAQLGKNYISAWELQRKDQLQQKIMCPGPVTCLTASPNGLYVLAGVAESIHLWEVSTG 111
LLAA + I W L+ K + P V + +++ + E + + G
Sbjct: 282 LLAAGFDNSCIKLWSLRSKKLKSE----PHQVDV-----SRIHLACDILEEEDDEDDNAG 332
Query: 112 NLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHH 171
+ IL H V +F DSS +S +D + W L S ++ H
Sbjct: 333 TEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTV---------LYQGH 383
Query: 172 ALPITDLHCGFGGPLARV-ATSSLDQTVKLWEVSSG---ELLLSVLFDVSIMAVTMDLAE 227
A P+ DL P + A+ S D+T +LW + L DV V
Sbjct: 384 AYPVWDLDIS---PYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVD--CVKFHPNS 438
Query: 228 HHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSG 287
+++ G ++ ++ W Q+ S ++F GHR V L+ S +G L S
Sbjct: 439 NYLATGSTDKTVR-----LWSAQQGNSV-------RLFTGHRGPVLSLAFSPNGKYLASA 486
Query: 288 SHDETVRLWDVQS 300
D+ ++LWD+ S
Sbjct: 487 GEDQRLKLWDLAS 499
Score = 51.2 bits (121), Expect = 2e-06
Identities = 45/189 (23%), Positives = 75/189 (39%), Gaps = 26/189 (13%)
Query: 23 WELHSGANLLTYRGG-------QAGPRGLALLNGEYLLAAQLGKNYISAWELQRKDQLQQ 75
W+L S N + Y+G P L +G + A+L W R L+
Sbjct: 369 WDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARL-------WSFDRTYPLRI 421
Query: 76 KIMCPGPVTCLTASPNGLYVLAGVAE-SIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSS 134
V C+ PN Y+ G + ++ LW GN + + + H V L F+ +
Sbjct: 422 YAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGK 481
Query: 135 HFISGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSL 194
+ S G+D + +W L S R H IT L F +A++S+
Sbjct: 482 YLASAGEDQRLKLWDLASGTLYKELR---------GHTDNITSLT--FSPDSGLIASASM 530
Query: 195 DQTVKLWEV 203
D +V++W++
Sbjct: 531 DNSVRVWDI 539
Score = 43.1 bits (100), Expect = 5e-04
Identities = 50/223 (22%), Positives = 92/223 (41%), Gaps = 43/223 (19%)
Query: 122 QDVSCLQFTGDSSHFISGGKDCLVLVWSLCSV-LQADPSRIPAPRHVWSHHALPITDL-- 178
Q ++ + + DS +G + + +WSL S L+++P ++ R H A I +
Sbjct: 269 QLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSR---IHLACDILEEED 325
Query: 179 ---------------HCG------FGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDVS 217
HCG F + + + S D +++ W++ G +VL+
Sbjct: 326 DEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL--GSFTNTVLYQGH 383
Query: 218 IMAV-TMDLAEHHM-FCGGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCL 275
V +D++ + + F GS ++ W R +++ GH V C+
Sbjct: 384 AYPVWDLDISPYSLYFASGSHDRTARL----WSFDRTYPL-------RIYAGHLADVDCV 432
Query: 276 SVSTDGSVLLSGSHDETVRLWDVQSKQCIRT-VALKGPVTNAA 317
+ + L +GS D+TVRLW Q +R +GPV + A
Sbjct: 433 KFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLA 475
>gi|148727341 serine/threonine kinase receptor associated protein
[Homo sapiens]
Length = 350
Score = 57.8 bits (138), Expect = 2e-08
Identities = 57/221 (25%), Positives = 101/221 (45%), Gaps = 42/221 (19%)
Query: 105 LWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQADPSRIPAP 164
+W+ +G+ L+ L+ H V + FT DS++ ++GG+D L+ ++ L + +A+P I
Sbjct: 85 VWDAVSGDELMTLA-HKHIVKTVDFTQDSNYLLTGGQDKLLRIYDL-NKPEAEPKEI--- 139
Query: 165 RHVWSHHALPITD-LHCGFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDVSIMAVT- 222
S H I L C + S+ D+TV+LW+ ++ + S+ F++S+ ++
Sbjct: 140 ----SGHTSGIKKALWCSEDKQIL----SADDKTVRLWDHATMTEVKSLNFNMSVSSMEY 191
Query: 223 ------MDLAEHHMFCGGSEGSIFQVDLFTWPGQ-RERSFHPEQD---AG---------- 262
+ + S S+ + F P S HPE++ AG
Sbjct: 192 IPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLVAGGEDFKLYKYD 251
Query: 263 -------KVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLW 296
+ +KGH + C+ S DG + SGS D T+RLW
Sbjct: 252 YNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLW 292
Score = 38.5 bits (88), Expect = 0.012
Identities = 30/111 (27%), Positives = 51/111 (45%), Gaps = 14/111 (12%)
Query: 188 RVATSSLDQTVKLWEVSSGELLLSVLFDVSIMAVTMDLAEHHMFCGGSEGSIFQVDLFTW 247
+ AT++ D T K+W+ SG+ L+++ + V +++ GG + + DL
Sbjct: 73 KAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDL--- 129
Query: 248 PGQRERSFHPEQDAGKVFKGHRNQV-TCLSVSTDGSVLLSGSHDETVRLWD 297
PE + K GH + + L S D +L + D+TVRLWD
Sbjct: 130 -------NKPEAEP-KEISGHTSGIKKALWCSEDKQIL--SADDKTVRLWD 170
Score = 32.0 bits (71), Expect = 1.1
Identities = 14/70 (20%), Positives = 35/70 (50%), Gaps = 1/70 (1%)
Query: 80 PGPVTCLTASPNGLYVLAGVAE-SIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFIS 138
P + + P +++AG + ++ ++ ++G L H+ + C++F+ D + S
Sbjct: 223 PATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYAS 282
Query: 139 GGKDCLVLVW 148
G +D + +W
Sbjct: 283 GSEDGTLRLW 292
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 57.4 bits (137), Expect = 2e-08
Identities = 63/286 (22%), Positives = 103/286 (36%), Gaps = 62/286 (21%)
Query: 74 QQKIMCPGPVTCLTASPNGLYVLAGVAESIHLWEVSTGNLLVILSRHYQDVSCLQFTGDS 133
+ +++C C ++ + V + + +W TG L+ H + V+C FT S
Sbjct: 657 EDEVLC-----CAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSS 711
Query: 134 SHFI--SGGKDCLVLVWSLCSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVAT 191
H + +G DC + +W L R+ H + HC F +A+
Sbjct: 712 HHLLLATGSSDCFLKLWDL---------NQKECRNTMFGHTNSVN--HCRFSPDDKLLAS 760
Query: 192 SSLDQTVKLWEVSSGELLLSV---LFDVSIMAVTMDLAEHHMFCGGS----------EGS 238
S D T+KLW+ +S S+ F +++ D+ C S +
Sbjct: 761 CSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK 820
Query: 239 IFQVDLFT-------WPGQRER----SFHPEQDAGKV--------------------FKG 267
IF D+ T G F P+ V +G
Sbjct: 821 IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRG 880
Query: 268 HRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTVALKGPV 313
H + V + S DGS L+ S D+T+RLW+ + V LK V
Sbjct: 881 HLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEV 926
Score = 45.4 bits (106), Expect = 1e-04
Identities = 48/234 (20%), Positives = 91/234 (38%), Gaps = 39/234 (16%)
Query: 83 VTCLTASPNGLYVLAGVAE-SIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGK 141
V+C SP+ Y+ G +I + E+ + +H + V +QFT D IS
Sbjct: 964 VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSD 1023
Query: 142 DCLVLVWSL----CSVLQADPSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQT 197
D + VW+ C L+ + R + + +R+ + S D T
Sbjct: 1024 DAEIQVWNWQLDKCIFLRGHQETVKDFRLLKN-----------------SRLLSWSFDGT 1066
Query: 198 VKLWEVSSGELLLS-VLFDVSIMA--VTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERS 254
VK+W + +G V ++++ ++ D + I+ DL
Sbjct: 1067 VKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLL-------- 1118
Query: 255 FHPEQDAGKVFKGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRTVA 308
P + +GH V C + S D ++L +G + +R+W+V + + + A
Sbjct: 1119 --PLHE----LRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCA 1166
Score = 43.1 bits (100), Expect = 5e-04
Identities = 55/253 (21%), Positives = 97/253 (38%), Gaps = 46/253 (18%)
Query: 83 VTCLTASPNGLYVLAGVAESIHLWEVSTGNLL-VILSRHYQDVSCLQFTGDSSHFISGGK 141
V C + S +G ++ I L+++ T LL I + H+ + F+ + +
Sbjct: 801 VKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALS 860
Query: 142 DCLVLVWSLCSVLQADPSRIPAPRHV-WSHHALPITDLHCGFGGPLARVATSSLDQTVKL 200
V +W+ S + R H+ W H + F + TSS DQT++L
Sbjct: 861 QYCVELWNTDSRSKVADCR----GHLSWVHGVM--------FSPDGSSFLTSSDDQTIRL 908
Query: 201 WEVS----SGELLLSVLFDV-----SIMAVTMDLAEHHMFCGGSEGSIFQVDLFTW---- 247
WE + ++L DV +M + +D G G Q+D T
Sbjct: 909 WETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTG---QIDYLTEAQVS 965
Query: 248 -----PGQRERSFHPEQDA--------GKVFKG---HRNQVTCLSVSTDGSVLLSGSHDE 291
P + +F E A ++F+ H+ V + + D L+S S D
Sbjct: 966 CCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDA 1025
Query: 292 TVRLWDVQSKQCI 304
+++W+ Q +CI
Sbjct: 1026 EIQVWNWQLDKCI 1038
Score = 36.6 bits (83), Expect = 0.045
Identities = 24/110 (21%), Positives = 45/110 (40%), Gaps = 9/110 (8%)
Query: 98 GVAESIHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQAD 157
G +++ +++ TG L+ + H +V C F+ D + D V +W+
Sbjct: 634 GADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWN-------- 685
Query: 158 PSRIPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKLWEVSSGE 207
S H + H+ + H +AT S D +KLW+++ E
Sbjct: 686 -SMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKE 734
Score = 32.0 bits (71), Expect = 1.1
Identities = 12/41 (29%), Positives = 24/41 (58%)
Query: 266 KGHRNQVTCLSVSTDGSVLLSGSHDETVRLWDVQSKQCIRT 306
K H ++V C + STD + + S D+ V++W+ + + + T
Sbjct: 654 KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHT 694
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,931,785
Number of Sequences: 37866
Number of extensions: 822744
Number of successful extensions: 3693
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 206
Number of HSP's successfully gapped in prelim test: 67
Number of HSP's that attempted gapping in prelim test: 1892
Number of HSP's gapped (non-prelim): 1331
length of query: 432
length of database: 18,247,518
effective HSP length: 105
effective length of query: 327
effective length of database: 14,271,588
effective search space: 4666809276
effective search space used: 4666809276
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.