Search of human proteins with 134304856

Search of human proteins with 134304856

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|134304856 solute carrier family 6, member 7 [Homo sapiens]
         (636 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|134304856 solute carrier family 6, member 7 [Homo sapiens]        1300   0.0  
gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo sap...   623   e-178
gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo sap...   621   e-178
gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo sap...   621   e-178
gi|92859670 solute carrier family 6 (neurotransmitter transporte...   615   e-176
gi|6005715 solute carrier family 6 (amino acid transporter), mem...   551   e-157
gi|21361581 solute carrier family 6 (neurotransmitter transporte...   530   e-150
gi|188528618 solute carrier family 6 (neurotransmitter transport...   527   e-149
gi|171184408 solute carrier family 6 (neurotransmitter transport...   522   e-148
gi|171184406 solute carrier family 6 (neurotransmitter transport...   522   e-148
gi|171184404 solute carrier family 6 (neurotransmitter transport...   522   e-148
gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo sapi...   519   e-147
gi|4557046 solute carrier family 6 member 2 [Homo sapiens]            513   e-145
gi|7657587 solute carrier family 6 (neurotransmitter transporter...   513   e-145
gi|4507041 solute carrier family 6 (neurotransmitter transporter...   509   e-144
gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo sa...   504   e-143
gi|197276623 solute carrier family 6 (neurotransmitter transport...   498   e-141
gi|54607094 solute carrier family 6 (neurotransmitter transporte...   498   e-141
gi|4507043 solute carrier family 6 member 4 [Homo sapiens]            493   e-139
gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo sa...   423   e-118
gi|194018524 solute carrier family 6, member 18 [Homo sapiens]        382   e-106
gi|51468073 solute carrier family 6, member 19 [Homo sapiens]         379   e-105
gi|58219014 solute carrier family 6, member 17 [Homo sapiens]         363   e-100
gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo s...   360   2e-99
gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo s...   342   6e-94
gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo ...   295   7e-80
gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo s...   282   6e-76
gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo s...   174   2e-43
gi|197276625 solute carrier family 6 (neurotransmitter transport...   168   2e-41
gi|55749589 solute carrier family 6, member 16 [Homo sapiens]         157   2e-38

>gi|134304856 solute carrier family 6, member 7 [Homo sapiens]
          Length = 636

 Score = 1300 bits (3363), Expect = 0.0
 Identities = 636/636 (100%), Positives = 636/636 (100%)

Query: 1   MKKLQGAHLRKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNV 60
           MKKLQGAHLRKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNV
Sbjct: 1   MKKLQGAHLRKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNV 60

Query: 61  WRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGA 120
           WRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGA
Sbjct: 61  WRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGA 120

Query: 121 AMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALP 180
           AMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALP
Sbjct: 121 AMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALP 180

Query: 181 LNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSG 240
           LNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSG
Sbjct: 181 LNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSG 240

Query: 241 KVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLG 300
           KVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLG
Sbjct: 241 KVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLG 300

Query: 301 VGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVA 360
           VGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVA
Sbjct: 301 VGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVA 360

Query: 361 KAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLR 420
           KAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLR
Sbjct: 361 KAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLR 420

Query: 421 PKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQ 480
           PKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQ
Sbjct: 421 PKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQ 480

Query: 481 RFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPWAELLGI 540
           RFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPWAELLGI
Sbjct: 481 RFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPWAELLGI 540

Query: 541 LMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQS 600
           LMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQS
Sbjct: 541 LMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQS 600

Query: 601 PKPLMVHMRKYGGITSFENTAIEVDREIAEEEESMM 636
           PKPLMVHMRKYGGITSFENTAIEVDREIAEEEESMM
Sbjct: 601 PKPLMVHMRKYGGITSFENTAIEVDREIAEEEESMM 636


>gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo
           sapiens]
          Length = 652

 Score =  623 bits (1606), Expect = e-178
 Identities = 308/605 (50%), Positives = 421/605 (69%), Gaps = 24/605 (3%)

Query: 12  PVTPDLLMTPSDQGDVDLDV---DFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAY 68
           PV P    +P   G V  +    D    RGNW  +++F+L+ +GY VGLGNVWRFPY  Y
Sbjct: 21  PVAPS---SPEQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCY 77

Query: 69  TNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGL 128
            NGGGAF+ PYF+ML  CGIPLFF+ELS GQF+S G L VW+ISP+FKG G  M+++   
Sbjct: 78  RNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTY 137

Query: 129 VAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELC---LEHRVSKDGN--GALPLNL 183
           + IYYN++I    +Y F+S+T  LPW +C N WNT  C   L+     +G+   ALP NL
Sbjct: 138 IGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNL 197

Query: 184 TCTV-------SPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGV 236
           +  +       SPSEEYW  YVL +  S  IG+ GE+R  L  CL ++W++VFLC+++GV
Sbjct: 198 SHLLNHSLQRTSPSEEYWRLYVLKL--SDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGV 255

Query: 237 KSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIF 296
           KSSGKVVYFTATFPY++L +L VRGVTL GA+ GI +YLTPQ+  +L +KVW +AA QIF
Sbjct: 256 KSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIF 315

Query: 297 YSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPV 356
           YSLG  +GGL+T ASYN FH N YRD+ I+++ N  TS+ AGF IFS+LG+M+  LGV V
Sbjct: 316 YSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDV 375

Query: 357 DQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEF- 415
            +VA  GPGLAFV YP+A+T+LP+SP WS LFFFML+ LGL +QF  LET+VTA+ DE  
Sbjct: 376 SRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVG 435

Query: 416 -PYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVT 474
             + L+ K  V  G + VA +L+G+ LT+  G+YWL+L+D+Y+ASF L+V+    C+A+ 
Sbjct: 436 NEWILQKKTYVTLG-VAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIM 494

Query: 475 RVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPW 534
            +YG + + +DI MMLGF P L+F+ CW F+SPA +  ++V+++++YQP  Y  Y++P W
Sbjct: 495 YIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGW 554

Query: 535 AELLGILMGLLSCLMIPAGMLVAVLREEG-SLWERLQQASRPAMDWGPSLEENRTGMYVA 593
           A  +G LM L S L IP   +  + R +G +L +RL+ A++P+ DWGP+L E+RTG Y  
Sbjct: 555 AVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAP 614

Query: 594 TLAGS 598
           T+A S
Sbjct: 615 TIAPS 619


>gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo
           sapiens]
          Length = 633

 Score =  621 bits (1602), Expect = e-178
 Identities = 301/577 (52%), Positives = 412/577 (71%), Gaps = 18/577 (3%)

Query: 37  RGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELS 96
           RGNW  +++F+L+ +GY VGLGNVWRFPY  Y NGGGAF+ PYF+ML  CGIPLFF+ELS
Sbjct: 27  RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELS 86

Query: 97  LGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEH 156
            GQF+S G L VW+ISP+FKG G  M+++   + IYYN++I    +Y F+S+T  LPW +
Sbjct: 87  FGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAY 146

Query: 157 CGNWWNTELC---LEHRVSKDGN--GALPLNLTCTV-------SPSEEYWSRYVLHIQGS 204
           C N WNT  C   L+     +G+   ALP NL+  +       SPSEEYW  YVL +  S
Sbjct: 147 CNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKL--S 204

Query: 205 QGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTL 264
             IG+ GE+R  L  CL ++W++VFLC+++GVKSSGKVVYFTATFPY++L +L VRGVTL
Sbjct: 205 DDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTL 264

Query: 265 PGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTF 324
            GA+ GI +YLTPQ+  +L +KVW +AA QIFYSLG  +GGL+T ASYN FH N YRD+ 
Sbjct: 265 EGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSV 324

Query: 325 IVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFW 384
           I+++ N  TS+ AGF IFS+LG+M+  LGV V +VA  GPGLAFV YP+A+T+LP+SP W
Sbjct: 325 IISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLW 384

Query: 385 SFLFFFMLLTLGLDSQFAFLETIVTAVTDEF--PYYLRPKKAVFSGLICVAMYLMGLILT 442
           S LFFFML+ LGL +QF  LET+VTA+ DE    + L+ K  V  G + VA +L+G+ LT
Sbjct: 385 SLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLG-VAVAGFLLGIPLT 443

Query: 443 TDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACW 502
           +  G+YWL+L+D+Y+ASF L+V+    C+A+  +YG + + +DI MMLGF P L+F+ CW
Sbjct: 444 SQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICW 503

Query: 503 LFLSPATLLALMVYSIVKYQPSEYGSYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREE 562
            F+SPA +  ++V+++++YQP  Y  Y++P WA  +G LM L S L IP   +  + R +
Sbjct: 504 RFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTD 563

Query: 563 G-SLWERLQQASRPAMDWGPSLEENRTGMYVATLAGS 598
           G +L +RL+ A++P+ DWGP+L E+RTG Y  T+A S
Sbjct: 564 GDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTIAPS 600


>gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo
           sapiens]
          Length = 706

 Score =  621 bits (1602), Expect = e-178
 Identities = 301/577 (52%), Positives = 412/577 (71%), Gaps = 18/577 (3%)

Query: 37  RGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELS 96
           RGNW  +++F+L+ +GY VGLGNVWRFPY  Y NGGGAF+ PYF+ML  CGIPLFF+ELS
Sbjct: 100 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELS 159

Query: 97  LGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEH 156
            GQF+S G L VW+ISP+FKG G  M+++   + IYYN++I    +Y F+S+T  LPW +
Sbjct: 160 FGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAY 219

Query: 157 CGNWWNTELC---LEHRVSKDGN--GALPLNLTCTV-------SPSEEYWSRYVLHIQGS 204
           C N WNT  C   L+     +G+   ALP NL+  +       SPSEEYW  YVL +  S
Sbjct: 220 CNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKL--S 277

Query: 205 QGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTL 264
             IG+ GE+R  L  CL ++W++VFLC+++GVKSSGKVVYFTATFPY++L +L VRGVTL
Sbjct: 278 DDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTL 337

Query: 265 PGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTF 324
            GA+ GI +YLTPQ+  +L +KVW +AA QIFYSLG  +GGL+T ASYN FH N YRD+ 
Sbjct: 338 EGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSV 397

Query: 325 IVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFW 384
           I+++ N  TS+ AGF IFS+LG+M+  LGV V +VA  GPGLAFV YP+A+T+LP+SP W
Sbjct: 398 IISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLW 457

Query: 385 SFLFFFMLLTLGLDSQFAFLETIVTAVTDEF--PYYLRPKKAVFSGLICVAMYLMGLILT 442
           S LFFFML+ LGL +QF  LET+VTA+ DE    + L+ K  V  G + VA +L+G+ LT
Sbjct: 458 SLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLG-VAVAGFLLGIPLT 516

Query: 443 TDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACW 502
           +  G+YWL+L+D+Y+ASF L+V+    C+A+  +YG + + +DI MMLGF P L+F+ CW
Sbjct: 517 SQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICW 576

Query: 503 LFLSPATLLALMVYSIVKYQPSEYGSYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREE 562
            F+SPA +  ++V+++++YQP  Y  Y++P WA  +G LM L S L IP   +  + R +
Sbjct: 577 RFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTD 636

Query: 563 G-SLWERLQQASRPAMDWGPSLEENRTGMYVATLAGS 598
           G +L +RL+ A++P+ DWGP+L E+RTG Y  T+A S
Sbjct: 637 GDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTIAPS 673


>gi|92859670 solute carrier family 6 (neurotransmitter transporter,
           glycine), member 5 [Homo sapiens]
          Length = 797

 Score =  615 bits (1587), Expect = e-176
 Identities = 306/606 (50%), Positives = 408/606 (67%), Gaps = 31/606 (5%)

Query: 13  VTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGG 72
           V P  + T + Q D   D + A  RGNW+ KLDF+LS +GY VGLGNVWRFPY A+ NGG
Sbjct: 169 VLPGSVATVATQEDEQGDENKA--RGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGG 226

Query: 73  GAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIY 132
           GAFL+PY +MLA+ G+P+FFLE+SLGQF+S GP++VWK  P  +G G AML+I  L+AIY
Sbjct: 227 GAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIY 286

Query: 133 YNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLE-------------HRVSKDGNGAL 179
           YN+II Y LFYLFAS  S LPW  C N WNT  C +             H   +  N   
Sbjct: 287 YNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTF 346

Query: 180 PL----NLTCT----------VSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAW 225
            +    N+T            VS SEEY+  +VL I  S GI  PGEIRW L LCL LAW
Sbjct: 347 CMTAYPNVTMVNFTSQANKTFVSGSEEYFKYFVLKI--SAGIEYPGEIRWPLALCLFLAW 404

Query: 226 VIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSS 285
           VIV+  + KG+K+SGKVVYFTATFPY++L++LL+RGVTLPGA  GI +++TP++  L  +
Sbjct: 405 VIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDA 464

Query: 286 KVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVL 345
            VW +AA QIF+SL   +GGL+T +SYN FH N YRDT IVT  N+ TSI AGF IFSV+
Sbjct: 465 TVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVI 524

Query: 346 GYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLE 405
           G+M+ E  V ++ VA  GPG+AFVVYP+A+T LPLSPFW+ +FF MLLTLGLD+ FA +E
Sbjct: 525 GFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIE 584

Query: 406 TIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVV 465
           TIVT+++DEFP YLR  K VF+   C+  ++MG  + T GG+Y   L+D Y+AS+ L+++
Sbjct: 585 TIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVII 644

Query: 466 VITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSE 525
            I   + ++ VYG+QRFC DI MM+GF+P ++++ CW F++P  L  ++ +S  +++P  
Sbjct: 645 AIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMT 704

Query: 526 YGSYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEE 585
           YGSYR+P W+ +LG LM   S + IP   ++ +    G   ERL+    P  DWGP L +
Sbjct: 705 YGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQ 764

Query: 586 NRTGMY 591
           +R   Y
Sbjct: 765 HRGERY 770


>gi|6005715 solute carrier family 6 (amino acid transporter), member
           14 [Homo sapiens]
          Length = 642

 Score =  551 bits (1421), Expect = e-157
 Identities = 279/609 (45%), Positives = 388/609 (63%), Gaps = 45/609 (7%)

Query: 37  RGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELS 96
           RGNW+ K D+LLS IGY VGLGNVWRFPY  Y+NGGGAFL+PY +MLA+ G+PLFFLE S
Sbjct: 36  RGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECS 95

Query: 97  LGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEH 156
           LGQF+SLGP++VW+I PLF+G G  M+LI   V IYYN+IIAY L+Y+FAS  S+LPW++
Sbjct: 96  LGQFASLGPVSVWRILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKN 155

Query: 157 CGNWWNTEL--------CLEHRVSKDGNGALPLN--------LTCTVS---------PSE 191
           C +W +           C    V+K     + +N         TC            PSE
Sbjct: 156 CSSWSDKNCSRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSE 215

Query: 192 EYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPY 251
           +YW++  L  Q S G+   G I W L LCLLLAW+IV   + KG+KSSGKVVYFTA FPY
Sbjct: 216 QYWNKVAL--QRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPY 273

Query: 252 LILLMLLVRGVTLPGAWKGIQFYLTPQ--FHHLLSSKVWIEAALQIFYSLGVGFGGLLTF 309
           ++LL+LLVRG TL GA KGI +Y+  Q  F  L  ++VW +AA QIFYSL V +GGL+  
Sbjct: 274 VVLLILLVRGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAWGGLVAL 333

Query: 310 ASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFV 369
           +SYN F  N + D  +V L N +TS+ AGFAIFS+LG+M+   G  V QV K+G  LAF+
Sbjct: 334 SSYNKFKNNCFSDAIVVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFI 393

Query: 370 VYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGL 429
            YP+A+  LP  PFWS LFFFMLLTLGLDSQFA +ETI T + D FP  ++  +   +  
Sbjct: 394 AYPEALAQLPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFPKVMKKMRVPITLG 453

Query: 430 ICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMM 489
            C+ ++L+GL+  T  G+YW+ L+D + A +G+++  I   + +  +YG  RF  D  MM
Sbjct: 454 CCLVLFLLGLVCVTQAGIYWVHLIDHFCAGWGILIAAILELVGIIWIYGGNRFIEDTEMM 513

Query: 490 LGFKP---GLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPWAELLGILMGLLS 546
           +G K     L++RACW  ++P  L+A+ ++S+V++    YG+  +P W   LG  M +  
Sbjct: 514 IGAKRWIFWLWWRACWFVITPILLIAIFIWSLVQFHRPNYGAIPYPDWGVALGWCMIVFC 573

Query: 547 CLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMY-------------VA 593
            + IP   ++ +++ +G++++RL    RPA +WGP LE++R   Y             + 
Sbjct: 574 IIWIPIMAIIKIIQAKGNIFQRLISCCRPASNWGPYLEQHRGERYKDMVDPKKEADHEIP 633

Query: 594 TLAGSQSPK 602
           T++GS+ P+
Sbjct: 634 TVSGSRKPE 642


>gi|21361581 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 13 [Homo sapiens]
          Length = 602

 Score =  530 bits (1366), Expect = e-150
 Identities = 273/552 (49%), Positives = 363/552 (65%), Gaps = 10/552 (1%)

Query: 32  DFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLF 91
           D    RG+W  K++F+LS  G  +GLGNVWRFPY  Y NGGGAF +PY + L  CGIP+F
Sbjct: 27  DGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVF 86

Query: 92  FLELSLGQFSSLGPLAVW-KISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTS 150
            LE +LGQ++S G +  W KI P+F+G G A  +IV L+ +YY +++A+ LFYLF+S T 
Sbjct: 87  LLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTI 146

Query: 151 DLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEYWSRYVLHIQGSQGIGSP 210
           DLPW  C + WNTE C+E + +   NG+L        SP  E+W R VL I  S GI   
Sbjct: 147 DLPWGGCYHEWNTEHCMEFQKT---NGSLNGTSENATSPVIEFWERRVLKI--SDGIQHL 201

Query: 211 GEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKG 270
           G +RW L LCLLLAWVI + CI KGVKS+GKVVYFTATFPYL+L++LL+RGVTLPGA +G
Sbjct: 202 GALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQG 261

Query: 271 IQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGN 330
           IQFYL P    L   +VW++A  QIF+S  +  G L    SYN +H N YRD   +   N
Sbjct: 262 IQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLN 321

Query: 331 AITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFF 390
           + TS +AGFAIFS+LG+MSQE GVP+ +VA++GPGLAF+ YP+A+ MLP SP W+  FFF
Sbjct: 322 SGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFF 381

Query: 391 MLLTLGLDSQFAFLETIVTAVTDEFPYYLRPK--KAVFSGLICVAMYLMGLILTTDGGMY 448
           M++ LGLDSQF  +E++VTA+ D +P+  R K  + V    + V  +L+GLI+ T+GGMY
Sbjct: 382 MVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMY 441

Query: 449 WLVLLDDYSAS-FGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSP 507
              L D Y+AS   L+ V I   L V  VYG +RF  +I  M+G++P    + CWLFL+P
Sbjct: 442 VFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTP 501

Query: 508 ATLLALMVYSIVKYQPSEYG-SYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLW 566
           A   A  ++S++KY P  Y   Y +P W + LG L+ L S + IPA  L  +   +G   
Sbjct: 502 AVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFR 561

Query: 567 ERLQQASRPAMD 578
           ER++Q   PA D
Sbjct: 562 ERIRQLMCPAED 573


>gi|188528618 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 1 [Homo sapiens]
          Length = 599

 Score =  527 bits (1357), Expect = e-149
 Identities = 251/543 (46%), Positives = 360/543 (66%), Gaps = 11/543 (2%)

Query: 37  RGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELS 96
           R  W G+ DFL+SC+GY +GLGNVWRFPY    NGGGAFL+PYFL L   G+PLF LE S
Sbjct: 44  RDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECS 103

Query: 97  LGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEH 156
           LGQ++S+G L VWK++P+FKG G A  ++   + IYY +II++ ++YL+ S T+ LPW+ 
Sbjct: 104 LGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQ 163

Query: 157 CGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWN 216
           C N WNT+ C  +           +N T   S   E+W R  +H Q + G+  PG+IRW 
Sbjct: 164 CDNPWNTDRCFSNYSM--------VNTTNMTSAVVEFWERN-MH-QMTDGLDKPGQIRWP 213

Query: 217 LCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLT 276
           L + L +AW++V+ CI KGV  +GKVVYF+AT+PY++L++L  RGVTLPGA +GI FY+T
Sbjct: 214 LAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYIT 273

Query: 277 PQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSIL 336
           P F  L  S+VW++AA QIF+S G+G G L+   SYN+FH N+YRD+ IV   N+ TS+ 
Sbjct: 274 PNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMF 333

Query: 337 AGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLG 396
           AGF IFS++G+M+      +  VA +GPGLAF+ YP+A+T LP+SP W+ LFF MLL LG
Sbjct: 334 AGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLG 393

Query: 397 LDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDY 456
           +DSQF  +E  +TA+ DE+P  LR ++ +F   +C+  YL+GL   T GG+Y   L D Y
Sbjct: 394 IDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYY 453

Query: 457 SAS-FGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMV 515
           SAS   L+ +V   C++++  YG+ RF  +I  M+G +P ++++ CW F +P  +  + +
Sbjct: 454 SASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFI 513

Query: 516 YSIVKYQPSEYGSYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRP 575
           +S V+  P   G+Y FP W + +G LM L S ++IP  M    L  +GSL +R+Q   +P
Sbjct: 514 FSAVQMTPLTMGNYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQP 573

Query: 576 AMD 578
           + D
Sbjct: 574 SED 576


>gi|171184408 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  522 bits (1345), Expect = e-148
 Identities = 262/552 (47%), Positives = 360/552 (65%), Gaps = 11/552 (1%)

Query: 30  DVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIP 89
           D D    RG WT K++F+LS  G  +GLGNVWRFPY  Y NGGGAF +PYF+   +CGIP
Sbjct: 29  DEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIP 88

Query: 90  LFFLELSLGQFSSLGPLAVW-KISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASL 148
           +FFLE++LGQ++S G +  W KI PLF+G G A ++I   + +YY +I+A+ LFYLF+S 
Sbjct: 89  VFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSF 148

Query: 149 TSDLPWEHCGNWWNTELCLEHRVSKDGNGALPL-NLTCTVSPSEEYWSRYVLHIQGSQGI 207
           TS+LPW  C N+WNTE C +           P  N T   SP  E+W R VL I  + GI
Sbjct: 149 TSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFT---SPVMEFWERRVLGI--TSGI 203

Query: 208 GSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGA 267
              G +RW L LCLLLAWVI + CI KGVKS+GKVVYFTATFPYL+L++LL+RGVTLPGA
Sbjct: 204 HDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGA 263

Query: 268 WKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVT 327
           ++GI +YL P    L   +VW++A  QIF+S  +  G L    SYN +H N Y+D   + 
Sbjct: 264 YQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALC 323

Query: 328 LGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFL 387
             N+ TS +AGF +FS+LG+MSQE GVP+ +VA++GPGLAF+ +P+A+TM+PLS  WS L
Sbjct: 324 FLNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCL 383

Query: 388 FFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRP--KKAVFSGLICVAMYLMGLILTTDG 445
           FF ML+ LGLDSQF  +E +VTA  D FP  LR   ++ +    I V  YL+GL L T+G
Sbjct: 384 FFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEG 443

Query: 446 GMYWLVLLDDYSAS-FGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLF 504
           GMY   L D Y++S   L+ + +   + ++ VYG  RF  +I  M+G++P    +  WLF
Sbjct: 444 GMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLF 503

Query: 505 LSPATLLALMVYSIVKYQPSEYGS-YRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEG 563
           L+P   LA  ++S+ KY P +Y + Y +PPW   +G  + L S + +P  +++ +L+  G
Sbjct: 504 LTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRG 563

Query: 564 SLWERLQQASRP 575
              +RL+Q   P
Sbjct: 564 PFRKRLRQLITP 575


>gi|171184406 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  522 bits (1345), Expect = e-148
 Identities = 262/552 (47%), Positives = 360/552 (65%), Gaps = 11/552 (1%)

Query: 30  DVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIP 89
           D D    RG WT K++F+LS  G  +GLGNVWRFPY  Y NGGGAF +PYF+   +CGIP
Sbjct: 29  DEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIP 88

Query: 90  LFFLELSLGQFSSLGPLAVW-KISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASL 148
           +FFLE++LGQ++S G +  W KI PLF+G G A ++I   + +YY +I+A+ LFYLF+S 
Sbjct: 89  VFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSF 148

Query: 149 TSDLPWEHCGNWWNTELCLEHRVSKDGNGALPL-NLTCTVSPSEEYWSRYVLHIQGSQGI 207
           TS+LPW  C N+WNTE C +           P  N T   SP  E+W R VL I  + GI
Sbjct: 149 TSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFT---SPVMEFWERRVLGI--TSGI 203

Query: 208 GSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGA 267
              G +RW L LCLLLAWVI + CI KGVKS+GKVVYFTATFPYL+L++LL+RGVTLPGA
Sbjct: 204 HDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGA 263

Query: 268 WKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVT 327
           ++GI +YL P    L   +VW++A  QIF+S  +  G L    SYN +H N Y+D   + 
Sbjct: 264 YQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALC 323

Query: 328 LGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFL 387
             N+ TS +AGF +FS+LG+MSQE GVP+ +VA++GPGLAF+ +P+A+TM+PLS  WS L
Sbjct: 324 FLNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCL 383

Query: 388 FFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRP--KKAVFSGLICVAMYLMGLILTTDG 445
           FF ML+ LGLDSQF  +E +VTA  D FP  LR   ++ +    I V  YL+GL L T+G
Sbjct: 384 FFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEG 443

Query: 446 GMYWLVLLDDYSAS-FGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLF 504
           GMY   L D Y++S   L+ + +   + ++ VYG  RF  +I  M+G++P    +  WLF
Sbjct: 444 GMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLF 503

Query: 505 LSPATLLALMVYSIVKYQPSEYGS-YRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEG 563
           L+P   LA  ++S+ KY P +Y + Y +PPW   +G  + L S + +P  +++ +L+  G
Sbjct: 504 LTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRG 563

Query: 564 SLWERLQQASRP 575
              +RL+Q   P
Sbjct: 564 PFRKRLRQLITP 575


>gi|171184404 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  522 bits (1345), Expect = e-148
 Identities = 262/552 (47%), Positives = 360/552 (65%), Gaps = 11/552 (1%)

Query: 30  DVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIP 89
           D D    RG WT K++F+LS  G  +GLGNVWRFPY  Y NGGGAF +PYF+   +CGIP
Sbjct: 29  DEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIP 88

Query: 90  LFFLELSLGQFSSLGPLAVW-KISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASL 148
           +FFLE++LGQ++S G +  W KI PLF+G G A ++I   + +YY +I+A+ LFYLF+S 
Sbjct: 89  VFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSF 148

Query: 149 TSDLPWEHCGNWWNTELCLEHRVSKDGNGALPL-NLTCTVSPSEEYWSRYVLHIQGSQGI 207
           TS+LPW  C N+WNTE C +           P  N T   SP  E+W R VL I  + GI
Sbjct: 149 TSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFT---SPVMEFWERRVLGI--TSGI 203

Query: 208 GSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGA 267
              G +RW L LCLLLAWVI + CI KGVKS+GKVVYFTATFPYL+L++LL+RGVTLPGA
Sbjct: 204 HDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGA 263

Query: 268 WKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVT 327
           ++GI +YL P    L   +VW++A  QIF+S  +  G L    SYN +H N Y+D   + 
Sbjct: 264 YQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALC 323

Query: 328 LGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFL 387
             N+ TS +AGF +FS+LG+MSQE GVP+ +VA++GPGLAF+ +P+A+TM+PLS  WS L
Sbjct: 324 FLNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCL 383

Query: 388 FFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRP--KKAVFSGLICVAMYLMGLILTTDG 445
           FF ML+ LGLDSQF  +E +VTA  D FP  LR   ++ +    I V  YL+GL L T+G
Sbjct: 384 FFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEG 443

Query: 446 GMYWLVLLDDYSAS-FGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLF 504
           GMY   L D Y++S   L+ + +   + ++ VYG  RF  +I  M+G++P    +  WLF
Sbjct: 444 GMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLF 503

Query: 505 LSPATLLALMVYSIVKYQPSEYGS-YRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEG 563
           L+P   LA  ++S+ KY P +Y + Y +PPW   +G  + L S + +P  +++ +L+  G
Sbjct: 504 LTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRG 563

Query: 564 SLWERLQQASRP 575
              +RL+Q   P
Sbjct: 564 PFRKRLRQLITP 575


>gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo
           sapiens]
          Length = 635

 Score =  519 bits (1336), Expect = e-147
 Identities = 256/553 (46%), Positives = 354/553 (64%), Gaps = 13/553 (2%)

Query: 37  RGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELS 96
           R  WT ++DF++SC+G+ VGLGNVWRFPY  Y NGGG FL+PY L+  + GIP+FFLE+S
Sbjct: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111

Query: 97  LGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEH 156
           LGQF   G + VW I PLFKG G A ++IV     YY M++A+  +YL  S T+ LPW  
Sbjct: 112 LGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWAT 171

Query: 157 CGNWWNTELCLEHRVSKDGNGALPLNLTCTV-----SPSEEYWSRYVLHIQGSQGIGSPG 211
           CG+ WNT  C+E    +D   A   NLTC       SP  E+W   VL + G  G+  PG
Sbjct: 172 CGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSG--GLEVPG 229

Query: 212 EIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGI 271
            + W + LCLL  WV+V+ C+ KGVKS+GK+VYFTATFPY++L++LLVRGV LPGA  GI
Sbjct: 230 ALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGI 289

Query: 272 QFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNA 331
            +YL P +  L S +VWI+A  QIF+S  +G G L    SYN F+ N Y+D  I+ L N+
Sbjct: 290 IYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINS 349

Query: 332 ITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFM 391
            TS  AGF +FS+LG+M+ E GV + +VA++GPGLAF+ YP+A+T++P++P W+ LFFFM
Sbjct: 350 GTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFM 409

Query: 392 LLTLGLDSQFAFLETIVTAVTDEFP--YYLRPKKAVFSGLICVAMYLMGLILTTDGGMYW 449
           LL LGLDSQF  +E  +T + D  P  YY R ++ +   L C   +++ L + TDGGMY 
Sbjct: 410 LLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYV 469

Query: 450 LVLLDDYSAS-FGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPA 508
             L D YSAS   L+      C+ V  VYG  RF  DI  M+G++P  + + CW F +P 
Sbjct: 470 FQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPL 529

Query: 509 TLLALMVYSIVKYQPSEY-GSYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWE 567
             + + ++++V Y+P  Y  +Y +P W E +G    L S L +P  +L  +LR +G++ E
Sbjct: 530 VCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAE 589

Query: 568 RLQQASRPAMDWG 580
           R Q  ++P   WG
Sbjct: 590 RWQHLTQPI--WG 600


>gi|4557046 solute carrier family 6 member 2 [Homo sapiens]
          Length = 617

 Score =  513 bits (1322), Expect = e-145
 Identities = 255/546 (46%), Positives = 354/546 (64%), Gaps = 8/546 (1%)

Query: 34  AAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFL 93
           A  R  W  K+DFLLS +G+ V L NVWRFPY  Y NGGGAFL+PY L L I G+PLF++
Sbjct: 53  AQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYM 112

Query: 94  ELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLP 153
           EL+LGQ++  G   VWKI P FKG G A++LI   V  YYN+IIA+ L+YLF+S T +LP
Sbjct: 113 ELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLP 172

Query: 154 WEHCGNWWNTELCLEHRVSKDGNGALPLNLT----CTVSPSEEYWSRYVLHIQGSQGIGS 209
           W  CG+ WN+  C + ++    NG++  N T       +P+ E++ R VLH+  S GI  
Sbjct: 173 WTDCGHTWNSPNCTDPKLL---NGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHD 229

Query: 210 PGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWK 269
            G  +W L LCL++  ++++  + KGVK+SGKVV+ TAT PY +L +LLV GVTLPGA  
Sbjct: 230 IGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASN 289

Query: 270 GIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLG 329
           GI  YL   F+ L  + VWI+AA QIF+SLG GFG L+ FASYN F  N YRD  + +  
Sbjct: 290 GINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSI 349

Query: 330 NAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFF 389
           N ITS ++GFAIFS+LGYM+ E  V ++ VA  G GL F++YP+A++ L  S FW+ +FF
Sbjct: 350 NCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFF 409

Query: 390 FMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYW 449
            MLL LGLDS    +E ++T + D+F    R +K +F+  +  + +L+ L   T GG+Y 
Sbjct: 410 VMLLALGLDSSMGGMEAVITGLADDFQVLKRHRK-LFTFGVTFSTFLLALFCITKGGIYV 468

Query: 450 LVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPAT 509
           L LLD ++A   ++  V+   + V+  YG+ RF  DI  M+GF+PGLY+R CW F+SPA 
Sbjct: 469 LTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAF 528

Query: 510 LLALMVYSIVKYQPSEYGSYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERL 569
           LL ++V SI+ ++P  Y  Y FPPWA  +G  + L S +++P  ++   L  +GSLWERL
Sbjct: 529 LLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERL 588

Query: 570 QQASRP 575
                P
Sbjct: 589 AYGITP 594


>gi|7657587 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 11 [Homo sapiens]
          Length = 632

 Score =  513 bits (1321), Expect = e-145
 Identities = 258/553 (46%), Positives = 361/553 (65%), Gaps = 9/553 (1%)

Query: 32  DFAAH-RGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPL 90
           D A H RG+W  K++F+LS  G  +GLGNVWRFPY  Y NGGGAFL+PY +    CGIP+
Sbjct: 44  DKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPV 103

Query: 91  FFLELSLGQFSSLGPLAVW-KISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLT 149
           FFLE +LGQF+S G +  W K+ PLF+G G A  +I   + +YY +I+A+ +FYL    T
Sbjct: 104 FFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFT 163

Query: 150 SDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEYWSRYVLHIQGSQGIGS 209
           ++LPW  CG+ WNTE C+E +     N +  ++L    SP  E+W   VL I  S GI  
Sbjct: 164 TELPWATCGHEWNTENCVEFQKLNVSNYS-HVSLQNATSPVMEFWEHRVLAI--SDGIEH 220

Query: 210 PGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWK 269
            G +RW L LCLL AW I + CI KG KS+GKVVY TATFPY++LL+LL+RGVTLPGA +
Sbjct: 221 IGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASE 280

Query: 270 GIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLG 329
           GI+FYL P    L   +VW++A  QIF+S  +  G L    SYN ++ N YRD  ++   
Sbjct: 281 GIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCL 340

Query: 330 NAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFF 389
           N+ TS +AGFAIFSVLG+M+ E GVP+ +VA++GPGLAF+ YP+A+TM+PLSP W+ LFF
Sbjct: 341 NSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFF 400

Query: 390 FMLLTLGLDSQFAFLETIVTAVTDEFPYYLRP--KKAVFSGLICVAMYLMGLILTTDGGM 447
            ML+ LGLDSQF  +E++VTAV D +P   R   ++ +    + V  Y +GL++ T+GGM
Sbjct: 401 MMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGM 460

Query: 448 YWLVLLDDYSAS-FGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLS 506
           Y   L D Y+AS   L+ V I  C+ +  VYG  RF  +I  M+G++P    + CW+ ++
Sbjct: 461 YIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMT 520

Query: 507 PATLLALMVYSIVKYQPSEYGS-YRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSL 565
           P     + ++ ++KY+P +Y + Y +P W   +G LM L S L IP  + + V + EG+L
Sbjct: 521 PGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTL 580

Query: 566 WERLQQASRPAMD 578
            E+LQ+ + P+ D
Sbjct: 581 PEKLQKLTTPSTD 593


>gi|4507041 solute carrier family 6 (neurotransmitter transporter,
           dopamine), member 3 [Homo sapiens]
          Length = 620

 Score =  509 bits (1312), Expect = e-144
 Identities = 253/545 (46%), Positives = 344/545 (63%), Gaps = 1/545 (0%)

Query: 34  AAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFL 93
           A  R  W  K+DFLLS IG+ V L NVWRFPY  Y NGGGAFLVPY L + I G+PLF++
Sbjct: 57  AQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYM 116

Query: 94  ELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLP 153
           EL+LGQF+  G   VWKI P+ KG G  ++LI   V  +YN+IIA+ L YLF+S T++LP
Sbjct: 117 ELALGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELP 176

Query: 154 WEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEI 213
           W HC N WN+  C +         +  LN T   +P+ EY+ R VLH+  S GI   G  
Sbjct: 177 WIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPP 236

Query: 214 RWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQF 273
           RW L  CL+L  V+++  + KGVK+SGKVV+ TAT PY++L  LL+RGVTLPGA  GI+ 
Sbjct: 237 RWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRA 296

Query: 274 YLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAIT 333
           YL+  F+ L  + VWI+AA Q+ +SLGVGFG L+ F+SYN F  N YRD  + T  N++T
Sbjct: 297 YLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLT 356

Query: 334 SILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLL 393
           S  +GF +FS LGYM+Q+  VP+  VAK GPGL F++YP+A+  LPLS  W+ +FF MLL
Sbjct: 357 SFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLL 416

Query: 394 TLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLL 453
           TLG+DS    +E+++T + DEF   L   + +F+  I +A +L+ L   T+GG+Y   LL
Sbjct: 417 TLGIDSAMGGMESVITGLIDEF-QLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLL 475

Query: 454 DDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLAL 513
           D ++A   ++  V+   + V   YG+ +F  DI  M G +P LY+R CW  +SP  LL +
Sbjct: 476 DHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFV 535

Query: 514 MVYSIVKYQPSEYGSYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQAS 573
           +V SIV ++P  YG+Y FP WA  LG ++   S  M+P           GS  E+L  A 
Sbjct: 536 VVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAI 595

Query: 574 RPAMD 578
            P  D
Sbjct: 596 APEKD 600


>gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo
           sapiens]
          Length = 625

 Score =  504 bits (1298), Expect = e-143
 Identities = 252/553 (45%), Positives = 347/553 (62%), Gaps = 23/553 (4%)

Query: 37  RGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELS 96
           R  WT ++DF++SC+G+ VGLGNVWRFPY  Y NGGG FL+PY L+  + GIP+FFLE+S
Sbjct: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111

Query: 97  LGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEH 156
           LGQF   G + VW I PLFKG G A ++IV     YY M++A+  +YL  S T+ LPW  
Sbjct: 112 LGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWAT 171

Query: 157 CGNWWNTELCLEHRVSKDGNGALPLNLTCTV-----SPSEEYWSRYVLHIQGSQGIGSPG 211
           CG+ WNT  C+E    +D   A   NLTC       SP  E+W   VL + G  G+  PG
Sbjct: 172 CGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSG--GLEVPG 229

Query: 212 EIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGI 271
            + W + LCLL  WV+V+ C+ KGVKS+GK+VYFTATFPY++L++LLVRGV LPGA  GI
Sbjct: 230 ALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGI 289

Query: 272 QFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNA 331
            +YL P +  L S +VWI+A  QIF+S  +G G L    SYN F+ N Y           
Sbjct: 290 IYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYNG--------- 340

Query: 332 ITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFM 391
            TS  AGF +FS+LG+M+ E GV + +VA++GPGLAF+ YP+A+T++P++P W+ LFFFM
Sbjct: 341 -TSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFM 399

Query: 392 LLTLGLDSQFAFLETIVTAVTDEFP--YYLRPKKAVFSGLICVAMYLMGLILTTDGGMYW 449
           LL LGLDSQF  +E  +T + D  P  YY R ++ +   L C   +++ L + TDGGMY 
Sbjct: 400 LLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYV 459

Query: 450 LVLLDDYSAS-FGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPA 508
             L D YSAS   L+      C+ V  VYG  RF  DI  M+G++P  + + CW F +P 
Sbjct: 460 FQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPL 519

Query: 509 TLLALMVYSIVKYQPSEY-GSYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWE 567
             + + ++++V Y+P  Y  +Y +P W E +G    L S L +P  +L  +LR +G++ E
Sbjct: 520 VCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAE 579

Query: 568 RLQQASRPAMDWG 580
           R Q  ++P   WG
Sbjct: 580 RWQHLTQPI--WG 590


>gi|197276623 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  498 bits (1283), Expect = e-141
 Identities = 247/544 (45%), Positives = 351/544 (64%), Gaps = 7/544 (1%)

Query: 37  RGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELS 96
           R  W+ K+DF+LS  G  VGLGNVWRFPY  Y NGGGAFL+PYF+ L   G+P+FFLE+ 
Sbjct: 41  REKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEII 100

Query: 97  LGQFSSLGPLAVW-KISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWE 155
           +GQ++S G +  W KI PLF G G A ++IV L+ +YY +I+A+  +YLF S   +LPW 
Sbjct: 101 IGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWA 160

Query: 156 HCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRW 215
           HC + WNT  C+E  + K+ +  + ++ T   SP  E+W R VL +  S GI  PG ++W
Sbjct: 161 HCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSL--SPGIDHPGSLKW 218

Query: 216 NLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYL 275
           +L LCLLL W++ F CI KGV+S+GKVVYFTATFP+ +LL+LLVRG+TLPGA  GI+FYL
Sbjct: 219 DLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYL 278

Query: 276 TPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSI 335
            P    L   +VWI+A  QIF+S  +  G + +  SYN +  N YRD  ++   N+ TS 
Sbjct: 279 YPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSF 338

Query: 336 LAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTL 395
           ++GFAIFS+LG+M+QE GV +  VA++GPGLAF+ YP+A+TM+PL  FWS LFF MLL L
Sbjct: 339 VSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLL 398

Query: 396 GLDSQFAFLETIVTAVTDEFPYYLRP--KKAVFSGLICVAMYLMGLILTTDGGMYWLVLL 453
           GLDSQF  +E  +T++ D +P +LR   ++ +F   +C   YL+GL + T+GGMY   L 
Sbjct: 399 GLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLF 458

Query: 454 DDYSAS-FGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLA 512
           D Y+AS   L+ V    C  +  +YG       I  M+G++PG + +  W  ++P   + 
Sbjct: 459 DYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVG 518

Query: 513 LMVYSIVKYQPSEYG-SYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQ 571
             ++S+VKY P  Y  +Y +P WA  LG  + L S L +P  +++ + + EG    R++ 
Sbjct: 519 CFIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKY 578

Query: 572 ASRP 575
              P
Sbjct: 579 LLTP 582


>gi|54607094 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  498 bits (1283), Expect = e-141
 Identities = 247/544 (45%), Positives = 351/544 (64%), Gaps = 7/544 (1%)

Query: 37  RGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELS 96
           R  W+ K+DF+LS  G  VGLGNVWRFPY  Y NGGGAFL+PYF+ L   G+P+FFLE+ 
Sbjct: 41  REKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEII 100

Query: 97  LGQFSSLGPLAVW-KISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWE 155
           +GQ++S G +  W KI PLF G G A ++IV L+ +YY +I+A+  +YLF S   +LPW 
Sbjct: 101 IGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWA 160

Query: 156 HCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRW 215
           HC + WNT  C+E  + K+ +  + ++ T   SP  E+W R VL +  S GI  PG ++W
Sbjct: 161 HCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSL--SPGIDHPGSLKW 218

Query: 216 NLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYL 275
           +L LCLLL W++ F CI KGV+S+GKVVYFTATFP+ +LL+LLVRG+TLPGA  GI+FYL
Sbjct: 219 DLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYL 278

Query: 276 TPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSI 335
            P    L   +VWI+A  QIF+S  +  G + +  SYN +  N YRD  ++   N+ TS 
Sbjct: 279 YPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSF 338

Query: 336 LAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTL 395
           ++GFAIFS+LG+M+QE GV +  VA++GPGLAF+ YP+A+TM+PL  FWS LFF MLL L
Sbjct: 339 VSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLL 398

Query: 396 GLDSQFAFLETIVTAVTDEFPYYLRP--KKAVFSGLICVAMYLMGLILTTDGGMYWLVLL 453
           GLDSQF  +E  +T++ D +P +LR   ++ +F   +C   YL+GL + T+GGMY   L 
Sbjct: 399 GLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLF 458

Query: 454 DDYSAS-FGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLA 512
           D Y+AS   L+ V    C  +  +YG       I  M+G++PG + +  W  ++P   + 
Sbjct: 459 DYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVG 518

Query: 513 LMVYSIVKYQPSEYG-SYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQ 571
             ++S+VKY P  Y  +Y +P WA  LG  + L S L +P  +++ + + EG    R++ 
Sbjct: 519 CFIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKY 578

Query: 572 ASRP 575
              P
Sbjct: 579 LLTP 582


>gi|4507043 solute carrier family 6 member 4 [Homo sapiens]
          Length = 630

 Score =  493 bits (1269), Expect = e-139
 Identities = 253/569 (44%), Positives = 360/569 (63%), Gaps = 23/569 (4%)

Query: 12  PVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNG 71
           P T   L+    QG+          R  W  K+DFLLS IGY V LGNVWRFPY  Y NG
Sbjct: 64  PATTTTLVAELHQGE----------RETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNG 113

Query: 72  GGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVW-KISPLFKGAGAAMLLIVGLVA 130
           GGAFL+PY +M    GIPLF++EL+LGQ+   G +++W KI P+FKG G A+ +I   +A
Sbjct: 114 GGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIA 173

Query: 131 IYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTV--- 187
            YYN I+A+ L+YL +S T  LPW  C N WNT  C  +  S+D       N+T T+   
Sbjct: 174 SYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNY-FSED-------NITWTLHST 225

Query: 188 SPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTA 247
           SP+EE+++R+VL I  S+G+   G I W L LC++L + +++  I KGVK+SGKVV+ TA
Sbjct: 226 SPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTA 285

Query: 248 TFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLL 307
           TFPY+IL +LLVRG TLPGAW+G+ FYL P +  LL + VWI+AA QIF+SLG GFG LL
Sbjct: 286 TFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLL 345

Query: 308 TFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAK-AGPGL 366
            FASYN F+ N Y+D  + ++ N +TS ++GF IF+VLGYM++     V +VAK AGP L
Sbjct: 346 AFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSL 405

Query: 367 AFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVF 426
            F+ Y +A+  +P S F++ +FF ML+TLGLDS FA LE ++TAV DEFP+    ++  F
Sbjct: 406 LFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERF 465

Query: 427 SGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDI 486
              + +  +   L+  T GG Y + LL++Y+    ++ V +   +AV+  YGI +FCRD+
Sbjct: 466 VLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDV 525

Query: 487 HMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPWAELLGILMGLLS 546
             MLGF PG ++R CW+ +SP  LL ++   ++         Y +P W+ +LG  +G  S
Sbjct: 526 KEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSS 585

Query: 547 CLMIPAGMLVAVLREEGSLWERLQQASRP 575
            + IP  +   ++   G+  ER+ ++  P
Sbjct: 586 FICIPTYIAYRLIITPGTFKERIIKSITP 614


>gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo
           sapiens]
          Length = 520

 Score =  423 bits (1087), Expect = e-118
 Identities = 215/486 (44%), Positives = 302/486 (62%), Gaps = 13/486 (2%)

Query: 104 GPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNT 163
           G + VW I PLFKG G A ++IV     YY M++A+  +YL  S T+ LPW  CG+ WNT
Sbjct: 4   GSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNT 63

Query: 164 ELCLEHRVSKDGNGALPLNLTCTV-----SPSEEYWSRYVLHIQGSQGIGSPGEIRWNLC 218
             C+E    +D   A   NLTC       SP  E+W   VL + G  G+  PG + W + 
Sbjct: 64  PDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSG--GLEVPGALNWEVT 121

Query: 219 LCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQ 278
           LCLL  WV+V+ C+ KGVKS+GK+VYFTATFPY++L++LLVRGV LPGA  GI +YL P 
Sbjct: 122 LCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPD 181

Query: 279 FHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAG 338
           +  L S +VWI+A  QIF+S  +G G L    SYN F+ N Y+D  I+ L N+ TS  AG
Sbjct: 182 WSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAG 241

Query: 339 FAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLD 398
           F +FS+LG+M+ E GV + +VA++GPGLAF+ YP+A+T++P++P W+ LFFFMLL LGLD
Sbjct: 242 FVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLD 301

Query: 399 SQFAFLETIVTAVTDEFP--YYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDY 456
           SQF  +E  +T + D  P  YY R ++ +   L C   +++ L + TDGGMY   L D Y
Sbjct: 302 SQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYY 361

Query: 457 SAS-FGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMV 515
           SAS   L+      C+ V  VYG  RF  DI  M+G++P  + + CW F +P   + + +
Sbjct: 362 SASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFI 421

Query: 516 YSIVKYQPSEY-GSYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASR 574
           +++V Y+P  Y  +Y +P W E +G    L S L +P  +L  +LR +G++ ER Q  ++
Sbjct: 422 FNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQ 481

Query: 575 PAMDWG 580
           P   WG
Sbjct: 482 PI--WG 485


>gi|194018524 solute carrier family 6, member 18 [Homo sapiens]
          Length = 628

 Score =  382 bits (981), Expect = e-106
 Identities = 214/623 (34%), Positives = 322/623 (51%), Gaps = 91/623 (14%)

Query: 32  DFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLF 91
           D    R  W  K  +LLSC G+ VGLGN+WRFPY   T GGGAFL+PY + L   GIP+F
Sbjct: 13  DLGDERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIF 72

Query: 92  FLELSLGQFSSLGPLAVWK-ISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTS 150
            +EL++GQ    G + VW  ISP   G G   + +  L+++YYN I+A+VL+YL  S   
Sbjct: 73  HVELAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQH 132

Query: 151 DLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEY-WSRYVLHIQGSQGIGS 209
            LPW  C    N    +E                C  S +  Y W R  L+I     I  
Sbjct: 133 PLPWSSCPPDLNRTGFVEE---------------CQGSSAVSYFWYRQTLNITAD--IND 175

Query: 210 PGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWK 269
            G I+W L +CL  +W +V++C+++G++++GKV+YFTA FPYL+L + L+RG+TLPGA K
Sbjct: 176 SGSIQWWLLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATK 235

Query: 270 GIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLG 329
           G+ +  TP  H L + +VW++AA QIF+SL + FGG + FASYN+   +  +D  ++ L 
Sbjct: 236 GLIYLFTPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALV 295

Query: 330 NAITSILAGFAIFSVLGY----------------MSQELGVPVDQVAK------------ 361
           N +TS+ A  A+FSVLG+                +  +   P   +++            
Sbjct: 296 NRMTSLYASIAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNA 355

Query: 362 ------------------------AGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGL 397
                                   +GPGLAFVV+ +    +P +P W+ LFF ML TLGL
Sbjct: 356 TWPKRVAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGL 415

Query: 398 DSQFAFLETIVTAVTD--EFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDD 455
            + F  +E ++T + D    P ++ PK+A+ +GL+C+  +L     T   G YWL + D+
Sbjct: 416 STMFGTVEAVITPLLDVGVLPRWV-PKEAL-TGLVCLVCFLSATCFTLQSGNYWLEIFDN 473

Query: 456 YSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMV 515
           ++AS  L+++     + V  VYG++RFC DI  M G +P  Y+R  W  +SP  L   + 
Sbjct: 474 FAASPNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLLTIFVA 533

Query: 516 YSIVKY-QPSEYGSYR-------------FPPWAELLGILMGLLSCLMIPAGMLVAVLRE 561
           Y I+ + +P  Y ++              +P WA    +L+ LL  L +P   L  +L  
Sbjct: 534 YIILLFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLTR 593

Query: 562 EGSLWERLQQASRPAMDWGPSLE 584
               W    + +RP  D  P  +
Sbjct: 594 RRRTWR--DRDARPDTDMRPDTD 614


>gi|51468073 solute carrier family 6, member 19 [Homo sapiens]
          Length = 634

 Score =  379 bits (974), Expect = e-105
 Identities = 202/602 (33%), Positives = 321/602 (53%), Gaps = 88/602 (14%)

Query: 29  LDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGI 88
           ++ + A+ R  W  K  ++L+C+G+CVGLGNVWRFPY   ++GGGAF++P+ ++L + GI
Sbjct: 24  IEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGI 83

Query: 89  PLFFLELSLGQFSSLGPLAVWK-ISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFAS 147
           PL +LE ++GQ    G L VW  I P  KG G A +L   +V +YYN II+++++YLF S
Sbjct: 84  PLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNS 143

Query: 148 LTSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEYWSRYVLHIQGSQGI 207
               LPW  C             ++++  G +  +     SP + +W R  L+I  S  I
Sbjct: 144 FQEPLPWSDCP------------LNENQTGYV--DECARSSPVDYFWYRETLNI--STSI 187

Query: 208 GSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGA 267
              G I+W + LCL  AW ++++C ++G++++GK VY T+T PY++L + L+RG+TL GA
Sbjct: 188 SDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGA 247

Query: 268 WKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVT 327
             GI F  TP    L     W++A  Q+F+S  + FGGL++F+SYN+ H N  +D+ IV+
Sbjct: 248 TNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVS 307

Query: 328 LGNAITSILAGFAIFSVLGY---------------------------MSQELGVPVDQVA 360
           + N  TS+     ++SV+G+                           ++QE  V + Q  
Sbjct: 308 IINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRC 367

Query: 361 KA-------------------------GPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTL 395
            A                         G GLAF+V+ +A+T +PLSP WS LFF ML  L
Sbjct: 368 NASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCL 427

Query: 396 GLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDD 455
           GL S F  +E +V  + D      +  K V +GLIC+  +L+G I T + G YWL LLD 
Sbjct: 428 GLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDS 487

Query: 456 YSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMV 515
           Y+ S  L+++      +V  VYG+ RF +DI  M+G KP ++++  W  +SP  +L + +
Sbjct: 488 YAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFL 547

Query: 516 YSIV-----------------KYQPSEYGSYRFPPWAELLGILMGLLSCLMIPAGMLVAV 558
           +  V                 ++  S+  SY  P W  ++ +++  +  L IP   +  +
Sbjct: 548 FFFVVEVSQELTYSIWDPGYEEFPKSQKISY--PNWVYVVVVIVAGVPSLTIPGYAIYKL 605

Query: 559 LR 560
           +R
Sbjct: 606 IR 607


>gi|58219014 solute carrier family 6, member 17 [Homo sapiens]
          Length = 727

 Score =  363 bits (933), Expect = e-100
 Identities = 234/673 (34%), Positives = 347/673 (51%), Gaps = 107/673 (15%)

Query: 24  QGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLML 83
           Q  V+ ++D A  R  W  KL ++L+ IG+ VGLGN+WRFPY    NGGGA+LVPY ++L
Sbjct: 48  QKAVEEELD-AEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLL 106

Query: 84  AICGIPLFFLELSLGQFSSLGPLAVWK-ISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLF 142
            I GIPLFFLEL++GQ    G + VW  I P   G G +  ++   V +YYN+II + +F
Sbjct: 107 IIIGIPLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIF 166

Query: 143 YLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEY-WSRYVLHI 201
           Y F S    LPW  C             V ++G+ A+ +   C  S +  Y W R  L I
Sbjct: 167 YFFKSFQYPLPWSECP------------VVRNGSVAV-VEAECEKSSATTYFWYREALDI 213

Query: 202 QGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRG 261
             S  I   G + W + LCLL+AW IV + ++KG++SSGKV+YF++ FPY++L   LVRG
Sbjct: 214 --SDSISESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRG 271

Query: 262 VTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYR 321
           + L GA  GI    TP+   +L  +VW EAA Q+F++LG+GFGG++ F+SYN    N + 
Sbjct: 272 LLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHF 331

Query: 322 DTFIVTLGNAITSILAGFAIFS--------------------VLGYM-----SQELGVP- 355
           D  +V+  N  TS+LA   +F+                    +LGY+     S++L  P 
Sbjct: 332 DAALVSFINFFTSVLATLVVFAVLGFKANIMNEKCVVENAEKILGYLNTNVLSRDLIPPH 391

Query: 356 ------------------------------------VDQVAKA--GPGLAFVVYPQAMTM 377
                                                D++ K+  G GLAF+ + +AMT 
Sbjct: 392 VNFSHLTTKDYMEMYNVIMTVKEDQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTH 451

Query: 378 LPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLM 437
            P SPFWS +FF ML+ LGL S    +  I T + D F    +  K +F+   CV  +L+
Sbjct: 452 FPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTF----KVPKEMFTVGCCVFAFLV 507

Query: 438 GLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLY 497
           GL+     G Y++ + DDYSA+  L ++VI   +AV  +YG ++F +++  MLGF+P  +
Sbjct: 508 GLLFVQRSGNYFVTMFDDYSATLPLTLIVILENIAVAWIYGTKKFMQELTEMLGFRPYRF 567

Query: 498 FRACWLFLSPATLLALMVYSIVK--YQPSEYGSY----------RFPPWAELLGILMGLL 545
           +   W F+SP  +  L   SI++    P  Y ++           FP WA  L I + ++
Sbjct: 568 YFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSAWIKEEAAERYLYFPNWAMALLITLIVV 627

Query: 546 SCLMIPAGMLVAVLR-----EEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQS 600
           + L IP   +V VLR      +GS    +       M    +LEEN    ++ +   S++
Sbjct: 628 ATLPIP---VVFVLRHFHLLSDGSNTLSVSYKKGRMMKDISNLEENDETRFILSKVPSEA 684

Query: 601 PKPLMVHMRKYGG 613
           P P+  H R Y G
Sbjct: 685 PSPMPTH-RSYLG 696


>gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo
           sapiens]
          Length = 730

 Score =  360 bits (924), Expect = 2e-99
 Identities = 211/623 (33%), Positives = 320/623 (51%), Gaps = 99/623 (15%)

Query: 14  TPDLLMTPSDQGDVDLDV--DFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNG 71
           T +L++   ++ D D++   +    R  W  KL ++L+ +G+ VGLGNVWRFPY    NG
Sbjct: 36  TSELIVDGQEEKDTDVEEGSEVEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNG 95

Query: 72  GGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWK-ISPLFKGAGAAMLLIVGLVA 130
           GGA+L+PY ++L + GIPLFFLELS+GQ    G + VW  ISP   G G A  ++   VA
Sbjct: 96  GGAYLLPYLILLMVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVA 155

Query: 131 IYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPS 190
           +YYN+II + LFY   S    LPW+ C    N          +              S +
Sbjct: 156 LYYNVIIGWSLFYFSQSFQQPLPWDQCPLVKNASHTFVEPECEQS------------SAT 203

Query: 191 EEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFP 250
             YW R  L+I  S  I   G + W + +CLL AWV+V L ++KG++SSGK++YF++ FP
Sbjct: 204 TYYWYREALNISSS--ISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFP 261

Query: 251 YLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFA 310
           Y++L+  L+R   L G+  GI+   TP+   +L  KVW EAA Q+F++LG+GFGG++ F+
Sbjct: 262 YVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFS 321

Query: 311 SYNTFHQNIYRDT--------FIVTLGNAITSILAGFAI-----------------FSVL 345
           SYN    N + D         F   L   +   + GF                   F  +
Sbjct: 322 SYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKANVINEKCITQNSETIMKFLKM 381

Query: 346 GYMSQELGVP--------------------------------------VDQVAKA--GPG 365
           G +SQ++ +P                                       +++ KA  G G
Sbjct: 382 GNISQDI-IPHHINLSTVTAEDYHLVYDIIQKVKEEEFPALHLNSCKIEEELNKAVQGTG 440

Query: 366 LAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAV 425
           LAF+ + +AMT  P SPFWS +FF ML+ LGL S F  +E IVT + D F    + +K +
Sbjct: 441 LAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTF----KVRKEI 496

Query: 426 FSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRD 485
            + + C+  + +GLI     G Y++ + DDYSA+  L++VVI   +AV  VYGI +F  D
Sbjct: 497 LTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVCFVYGIDKFMED 556

Query: 486 IHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVK--YQPSEYGSY----------RFPP 533
           +  MLGF P  Y+   W ++SP  LL+L++ S+V     P  Y ++           +P 
Sbjct: 557 LKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKASEEFLSYPT 616

Query: 534 WAELLGILMGLLSCLMIPAGMLV 556
           W  ++ + + + + L +P   +V
Sbjct: 617 WGLVVCVSLVVFAILPVPVVFIV 639


>gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo
           sapiens]
          Length = 592

 Score =  342 bits (877), Expect = 6e-94
 Identities = 195/559 (34%), Positives = 289/559 (51%), Gaps = 75/559 (13%)

Query: 40  WTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQ 99
           W   L F+ +CI Y VGLGNVWRFPY     GGG+FLVPY +ML + G+PL +LEL++GQ
Sbjct: 8   WANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQ 67

Query: 100 FSSLGPLAVWK-ISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCG 158
               G +  W+ ISP   G G A +++   +++YYN+I A+  +YLF S    LPW  C 
Sbjct: 68  RMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVC- 126

Query: 159 NWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEY-WSRYVLHIQGSQGIGSPGEIRWNL 217
                          +GN     +  C  + S +Y W R  L+I  S  +   G ++W  
Sbjct: 127 -------------PLNGNHT-GYDEECEKASSTQYFWYRKTLNI--SPSLQENGGVQWEP 170

Query: 218 CLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTP 277
            LCLLLAW++V+LCIL+G +S+GKVVYFTA+ PY +L++ L+RG+TL GA  G+ +  TP
Sbjct: 171 ALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTP 230

Query: 278 QFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILA 337
           +   L + K WI AA QIF+SLG+GFG L+ FASYN    N  +   IV+L N+ TSI A
Sbjct: 231 KIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFA 290

Query: 338 GFAIFSVLGY----------------------------MSQELGVPVDQVAKAGPGLAFV 369
               FS+ G+                             +  L      +A A P     
Sbjct: 291 SIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSE 350

Query: 370 VYPQ--------------------------AMTMLPLSPFWSFLFFFMLLTLGLDSQFAF 403
           ++PQ                          A+  + +S  WS L+FFMLL LG+ S    
Sbjct: 351 MFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGN 410

Query: 404 LETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLM 463
              I+T +TD         K   SGL+C+    +G++ T + G YW  + +DY+A+  L+
Sbjct: 411 TAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLL 470

Query: 464 VVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQP 523
           ++V+   +AV  VYG++RF  D+  M G     Y++  W  +SP  +++L V+ +  Y  
Sbjct: 471 LIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYIL 530

Query: 524 SEYGSYRFPPWAELLGILM 542
           +  G+ ++  W    G L+
Sbjct: 531 T--GTLKYQAWDASQGQLV 547


>gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo
           sapiens]
          Length = 623

 Score =  295 bits (756), Expect = 7e-80
 Identities = 181/550 (32%), Positives = 273/550 (49%), Gaps = 97/550 (17%)

Query: 85  ICGIPLFFLELSLGQFSSLGPLAVWK-ISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFY 143
           + GIPLFFLELS+GQ    G + VW  ISP   G G A  ++   VA+YYN+II + LFY
Sbjct: 2   VIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFY 61

Query: 144 LFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEYWSRYVLHIQG 203
              S    LPW+ C    N          +              S +  YW R  L+I  
Sbjct: 62  FSQSFQQPLPWDQCPLVKNASHTFVEPECEQS------------SATTYYWYREALNISS 109

Query: 204 SQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVT 263
           S  I   G + W + +CLL AWV+V L ++KG++SSGK++YF++ FPY++L+  L+R   
Sbjct: 110 S--ISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFL 167

Query: 264 LPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDT 323
           L G+  GI+   TP+   +L  KVW EAA Q+F++LG+GFGG++ F+SYN    N + D 
Sbjct: 168 LNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDA 227

Query: 324 --------FIVTLGNAITSILAGFAI-----------------FSVLGYMSQELGVP--- 355
                   F   L   +   + GF                   F  +G +SQ++ +P   
Sbjct: 228 VLVSFINFFTSVLATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDI-IPHHI 286

Query: 356 -----------------------------------VDQVAKA--GPGLAFVVYPQAMTML 378
                                               +++ KA  G GLAF+ + +AMT  
Sbjct: 287 NLSTVTAEDYHLVYDIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHF 346

Query: 379 PLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMG 438
           P SPFWS +FF ML+ LGL S F  +E IVT + D F    + +K + + + C+  + +G
Sbjct: 347 PASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTF----KVRKEILTVICCLLAFCIG 402

Query: 439 LILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYF 498
           LI     G Y++ + DDYSA+  L++VVI   +AV  VYGI +F  D+  MLGF P  Y+
Sbjct: 403 LIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYY 462

Query: 499 RACWLFLSPATLLALMVYSIVK--YQPSEYGSY----------RFPPWAELLGILMGLLS 546
              W ++SP  LL+L++ S+V     P  Y ++           +P W  ++ + + + +
Sbjct: 463 YYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVSLVVFA 522

Query: 547 CLMIPAGMLV 556
            L +P   +V
Sbjct: 523 ILPVPVVFIV 532


>gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo
           sapiens]
          Length = 555

 Score =  282 bits (722), Expect = 6e-76
 Identities = 176/559 (31%), Positives = 262/559 (46%), Gaps = 112/559 (20%)

Query: 40  WTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQ 99
           W   L F+ +CI Y VGLGNVWRFPY     GGG+FLVPY +ML + G+PL +LEL++GQ
Sbjct: 8   WANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQ 67

Query: 100 FSSLGPLAVWK-ISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCG 158
               G +  W+ ISP   G G A +++   +++YYN+I A+  +YLF S    LPW  C 
Sbjct: 68  RMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVC- 126

Query: 159 NWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEY-WSRYVLHIQGSQGIGSPGEIRWNL 217
                          +GN     +  C  + S +Y W R  L+I  S  +   G ++W  
Sbjct: 127 -------------PLNGNHT-GYDEECEKASSTQYFWYRKTLNI--SPSLQENGGVQWEP 170

Query: 218 CLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTP 277
            LCLLLAW++V+LCIL+G +S+GK+                                   
Sbjct: 171 ALCLLLAWLVVYLCILRGTESTGKI----------------------------------- 195

Query: 278 QFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILA 337
               L + K WI AA QIF+SLG+GFG L+ FASYN    N  +   IV+L N+ TSI A
Sbjct: 196 --EQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFA 253

Query: 338 GFAIFSVLGY----------------------------MSQELGVPVDQVAKAGPGLAFV 369
               FS+ G+                             +  L      +A A P     
Sbjct: 254 SIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSE 313

Query: 370 VYPQ--------------------------AMTMLPLSPFWSFLFFFMLLTLGLDSQFAF 403
           ++PQ                          A+  + +S  WS L+FFMLL LG+ S    
Sbjct: 314 MFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGN 373

Query: 404 LETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLM 463
              I+T +TD         K   SGL+C+    +G++ T + G YW  + +DY+A+  L+
Sbjct: 374 TAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLL 433

Query: 464 VVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQP 523
           ++V+   +AV  VYG++RF  D+  M G     Y++  W  +SP  +++L V+ +  Y  
Sbjct: 434 LIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYIL 493

Query: 524 SEYGSYRFPPWAELLGILM 542
           +  G+ ++  W    G L+
Sbjct: 494 T--GTLKYQAWDASQGQLV 510


>gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo
           sapiens]
          Length = 289

 Score =  174 bits (442), Expect = 2e-43
 Identities = 97/248 (39%), Positives = 138/248 (55%), Gaps = 20/248 (8%)

Query: 14  TPDLLMTPSDQGDVDLDV--DFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNG 71
           T +L++   ++ D D++   +    R  W  KL ++L+ +G+ VGLGNVWRFPY    NG
Sbjct: 36  TSELIVDGQEEKDTDVEEGSEVEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNG 95

Query: 72  GGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWK-ISPLFKGAGAAMLLIVGLVA 130
           GGA+L+PY ++L + GIPLFFLELS+GQ    G + VW  ISP   G G A  ++   VA
Sbjct: 96  GGAYLLPYLILLMVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVA 155

Query: 131 IYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPS 190
           +YYN+II + LFY   S    LPW+ C    N          +              S +
Sbjct: 156 LYYNVIIGWSLFYFSQSFQQPLPWDQCPLVKNASHTFVEPECEQS------------SAT 203

Query: 191 EEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFP 250
             YW R  L+I  S  I   G + W + +CLL AWV+V L ++KG++SSGKV   +   P
Sbjct: 204 TYYWYREALNI--SSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKV---SMLEP 258

Query: 251 YLILLMLL 258
           +LILL+ +
Sbjct: 259 FLILLITI 266


>gi|197276625 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform b [Homo sapiens]
          Length = 200

 Score =  168 bits (425), Expect = 2e-41
 Identities = 77/159 (48%), Positives = 107/159 (67%), Gaps = 1/159 (0%)

Query: 37  RGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELS 96
           R  W+ K+DF+LS  G  VGLGNVWRFPY  Y NGGGAFL+PYF+ L   G+P+FFLE+ 
Sbjct: 41  REKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEII 100

Query: 97  LGQFSSLGPLAVW-KISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWE 155
           +GQ++S G +  W KI PLF G G A ++IV L+ +YY +I+A+  +YLF S   +LPW 
Sbjct: 101 IGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWA 160

Query: 156 HCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEYW 194
           HC + WNT  C+E  + K+ +  + ++ T   SP  E+W
Sbjct: 161 HCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFW 199


>gi|55749589 solute carrier family 6, member 16 [Homo sapiens]
          Length = 736

 Score =  157 bits (398), Expect = 2e-38
 Identities = 96/340 (28%), Positives = 169/340 (49%), Gaps = 25/340 (7%)

Query: 10  RKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYT 69
           +KP    + MT   + +V L   F      W+ K +++L+ +G+ +    +WRF Y    
Sbjct: 82  QKPTHEKVQMTEKKESEVLLARPF------WSSKTEYILAQVGFSMKPSCLWRFAYLWLN 135

Query: 70  NGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKI-SPLFKGAGAAMLLIVGL 128
           +GG +F   Y  ML + G+PL FLE++ GQ    G + VWKI +P   G G +  ++  +
Sbjct: 136 SGGCSFAAIYIFMLFLVGVPLLFLEMAAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFI 195

Query: 129 VAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCT-V 187
           + +Y+N++ ++++FY+  S    +PWE C             ++ + +G  P    C   
Sbjct: 196 LGLYFNVVNSWIIFYMSQSFQFPVPWEKCP------------LTMNSSGFDP---ECERT 240

Query: 188 SPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTA 247
           +PS  +W  Y   ++ S  I   G   ++L L   L W +V   ++ G+KS+GKV+Y   
Sbjct: 241 TPSIYFW--YQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLV 298

Query: 248 TFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLL 307
             P  I++   +R + L GA  G+Q  +  +   + +  VW  A  Q+  + G+G G + 
Sbjct: 299 LLPCFIIVGFFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVA 358

Query: 308 TFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGY 347
           + ASY     N   D F+V++ N +T ++     F VLG+
Sbjct: 359 SLASYMPQSNNCLSDAFLVSVINLLTLLVFTSFNFCVLGF 398



 Score =  122 bits (305), Expect = 1e-27
 Identities = 73/205 (35%), Positives = 109/205 (53%), Gaps = 13/205 (6%)

Query: 360 AKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYL 419
           A  GP  AF+ + +AM+ LP S FWSF+FF MLL +GL S    ++ I+T + D F ++ 
Sbjct: 473 ASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGIITPLQDTFSFFR 532

Query: 420 RPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGI 479
           +  K +  G + + M++ GL  T   G Y++ LL DY   F ++VVV+   +AV+  YG 
Sbjct: 533 KHTKLLIVG-VFLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIVVVVFETMAVSWAYGA 591

Query: 480 QRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVK--YQPSEYGSY-------- 529
           +RF  D+ ++LG      F   W  L P  LL + V  +V    +P  Y S+        
Sbjct: 592 RRFLADLTILLGHPISPIFGWLWPHLCPVVLLIIFVTMMVHLCMKPITYMSWDSSTSKEV 651

Query: 530 --RFPPWAELLGILMGLLSCLMIPA 552
              +PPWA LL I +  +  L IPA
Sbjct: 652 LRPYPPWALLLMITLFAIVILPIPA 676


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.327    0.143    0.459 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,714,430
Number of Sequences: 37866
Number of extensions: 1124416
Number of successful extensions: 3061
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 2911
Number of HSP's gapped (non-prelim): 52
length of query: 636
length of database: 18,247,518
effective HSP length: 109
effective length of query: 527
effective length of database: 14,120,124
effective search space: 7441305348
effective search space used: 7441305348
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.