Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 134142345
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|134142345 ATP-binding cassette, sub-family C, member 1
isoform 3 [Homo sapiens]
(1475 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 2921 0.0
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 2791 0.0
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 2729 0.0
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 2694 0.0
gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor... 2538 0.0
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 1227 0.0
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 1119 0.0
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 987 0.0
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 836 0.0
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 755 0.0
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 678 0.0
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 678 0.0
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 674 0.0
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 668 0.0
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 619 e-177
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 609 e-174
gi|221316556 ATP-binding cassette, sub-family C, member 3 isofor... 589 e-168
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 546 e-155
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 527 e-149
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 527 e-149
gi|21729876 ATP-binding cassette, sub-family C, member 11 isofor... 470 e-132
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor... 340 6e-93
gi|90421313 cystic fibrosis transmembrane conductance regulator ... 276 1e-73
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 184 5e-46
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 177 7e-44
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 174 7e-43
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 166 1e-40
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ... 162 3e-39
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member... 162 3e-39
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 159 1e-38
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 2921 bits (7573), Expect = 0.0
Identities = 1475/1475 (100%), Positives = 1475/1475 (100%)
Query: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH
Sbjct: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
Query: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA
Sbjct: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
Query: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS
Sbjct: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
Query: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD
Sbjct: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
Query: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL
Sbjct: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
Query: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD
Sbjct: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
Query: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV
Sbjct: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
Query: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN
Sbjct: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
Query: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK
Sbjct: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
Query: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP
Sbjct: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
Query: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT
Sbjct: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
Query: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND 720
LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND
Sbjct: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND 720
Query: 721 SLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKTRILVTHSMSYLPQVD 780
SLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKTRILVTHSMSYLPQVD
Sbjct: 721 SLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKTRILVTHSMSYLPQVD 780
Query: 781 VIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQM 840
VIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQM
Sbjct: 781 VIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQM 840
Query: 841 ENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTG 900
ENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTG
Sbjct: 841 ENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTG 900
Query: 901 QVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRL 960
QVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRL
Sbjct: 901 QVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRL 960
Query: 961 SVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRF 1020
SVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRF
Sbjct: 961 SVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRF 1020
Query: 1021 SKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVAS 1080
SKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVAS
Sbjct: 1021 SKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVAS 1080
Query: 1081 SRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVAN 1140
SRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVAN
Sbjct: 1081 SRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVAN 1140
Query: 1141 RWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMET 1200
RWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMET
Sbjct: 1141 RWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMET 1200
Query: 1201 NIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVT 1260
NIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVT
Sbjct: 1201 NIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVT 1260
Query: 1261 INGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQD 1320
INGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQD
Sbjct: 1261 INGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQD 1320
Query: 1321 PVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQ 1380
PVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQ
Sbjct: 1321 PVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQ 1380
Query: 1381 LVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTR 1440
LVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTR
Sbjct: 1381 LVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTR 1440
Query: 1441 VIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1475
VIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV
Sbjct: 1441 VIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1475
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 2791 bits (7234), Expect = 0.0
Identities = 1427/1478 (96%), Positives = 1436/1478 (97%), Gaps = 9/1478 (0%)
Query: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH
Sbjct: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
Query: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA
Sbjct: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
Query: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS
Sbjct: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
Query: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD
Sbjct: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
Query: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL
Sbjct: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
Query: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD
Sbjct: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
Query: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV
Sbjct: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
Query: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN
Sbjct: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
Query: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK
Sbjct: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
Query: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP
Sbjct: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
Query: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT
Sbjct: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
Query: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND 720
LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG Q+ Q
Sbjct: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNLSGGQK---QRV 717
Query: 721 SLRENILFGCQL---EEPYYRSVIQACALLPDLEILPSGDRTEIGEKTRILVTHSMSYLP 777
SL + + ++P S + A E + G + + KTRILVTHSMSYLP
Sbjct: 718 SLARAVYSNADIYLFDDPL--SAVDAHVGKHIFENV-IGPKGMLKNKTRILVTHSMSYLP 774
Query: 778 QVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEA 837
QVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEA
Sbjct: 775 QVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEA 834
Query: 838 KQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKA 897
KQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKA
Sbjct: 835 KQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKA 894
Query: 898 QTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTK 957
QTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTK
Sbjct: 895 QTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTK 954
Query: 958 VRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLV 1017
VRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLV
Sbjct: 955 VRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLV 1014
Query: 1018 NRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFY 1077
NRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFY
Sbjct: 1015 NRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFY 1074
Query: 1078 VASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSI 1137
VASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSI
Sbjct: 1075 VASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSI 1134
Query: 1138 VANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSE 1197
VANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSE
Sbjct: 1135 VANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSE 1194
Query: 1198 METNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHI 1257
METNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHI
Sbjct: 1195 METNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHI 1254
Query: 1258 NVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITII 1317
NVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITII
Sbjct: 1255 NVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITII 1314
Query: 1318 PQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVG 1377
PQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVG
Sbjct: 1315 PQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVG 1374
Query: 1378 QRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMD 1437
QRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMD
Sbjct: 1375 QRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMD 1434
Query: 1438 YTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1475
YTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV
Sbjct: 1435 YTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1472
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 2729 bits (7074), Expect = 0.0
Identities = 1402/1531 (91%), Positives = 1419/1531 (92%), Gaps = 56/1531 (3%)
Query: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH
Sbjct: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
Query: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA
Sbjct: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
Query: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS
Sbjct: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
Query: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD
Sbjct: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
Query: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL
Sbjct: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
Query: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD
Sbjct: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
Query: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV
Sbjct: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
Query: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN
Sbjct: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
Query: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK
Sbjct: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
Query: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP
Sbjct: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
Query: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT
Sbjct: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
Query: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND 720
LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND
Sbjct: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND 720
Query: 721 SLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEK--------------TR 766
SLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEK R
Sbjct: 721 SLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLAR 780
Query: 767 ILVTHSMSY-----LPQVDVII--------------------VMSGGKISEMGSYQELLA 801
+ +++ Y L VD + ++ +S + ++
Sbjct: 781 AVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIV 840
Query: 802 RDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK--------- 852
G + +Y A + + +E ENG+ GK
Sbjct: 841 MSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGM 900
Query: 853 --------QLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKL 904
QLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKL
Sbjct: 901 LVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKL 960
Query: 905 SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYG 964
SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYG
Sbjct: 961 SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYG 1020
Query: 965 ALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKEL 1024
ALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKEL
Sbjct: 1021 ALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKEL 1080
Query: 1025 DTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQL 1084
DTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQL
Sbjct: 1081 DTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQL 1140
Query: 1085 KRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLA 1144
KRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLA
Sbjct: 1141 KRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLA 1200
Query: 1145 VRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVA 1204
VRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVA
Sbjct: 1201 VRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVA 1260
Query: 1205 VERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGG 1264
VERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGG
Sbjct: 1261 VERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGG 1320
Query: 1265 EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF 1324
EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF
Sbjct: 1321 EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF 1380
Query: 1325 SGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCL 1384
SGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCL
Sbjct: 1381 SGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCL 1440
Query: 1385 ARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVL 1444
ARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVL
Sbjct: 1441 ARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVL 1500
Query: 1445 DKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1475
DKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV
Sbjct: 1501 DKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1531
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 2694 bits (6982), Expect = 0.0
Identities = 1380/1478 (93%), Positives = 1393/1478 (94%), Gaps = 65/1478 (4%)
Query: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH
Sbjct: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
Query: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA
Sbjct: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
Query: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS
Sbjct: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
Query: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD
Sbjct: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
Query: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL
Sbjct: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
Query: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD
Sbjct: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
Query: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV
Sbjct: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
Query: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN
Sbjct: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
Query: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK
Sbjct: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
Query: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP
Sbjct: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
Query: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT
Sbjct: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
Query: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND 720
LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIK +
Sbjct: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRIL----------- 709
Query: 721 SLRENILFGCQLEEPYYRSVIQACALLPDLE---ILPSGDRTEIGEKTRILVTHSMSYLP 777
V + + LP ++ ++ G +E+G +L
Sbjct: 710 -------------------VTHSMSYLPQVDVIIVMSGGKISEMGSYQELL--------- 741
Query: 778 QVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEA 837
+ G++ E L RTYASTEQEQDAEENGVTGVSGPGKEA
Sbjct: 742 -------------ARDGAFAEFL----------RTYASTEQEQDAEENGVTGVSGPGKEA 778
Query: 838 KQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKA 897
KQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKA
Sbjct: 779 KQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKA 838
Query: 898 QTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTK 957
QTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTK
Sbjct: 839 QTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTK 898
Query: 958 VRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLV 1017
VRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLV
Sbjct: 899 VRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLV 958
Query: 1018 NRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFY 1077
NRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFY
Sbjct: 959 NRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFY 1018
Query: 1078 VASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSI 1137
VASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSI
Sbjct: 1019 VASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSI 1078
Query: 1138 VANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSE 1197
VANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSE
Sbjct: 1079 VANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSE 1138
Query: 1198 METNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHI 1257
METNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHI
Sbjct: 1139 METNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHI 1198
Query: 1258 NVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITII 1317
NVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITII
Sbjct: 1199 NVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITII 1258
Query: 1318 PQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVG 1377
PQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVG
Sbjct: 1259 PQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVG 1318
Query: 1378 QRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMD 1437
QRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMD
Sbjct: 1319 QRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMD 1378
Query: 1438 YTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1475
YTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV
Sbjct: 1379 YTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1416
>gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5
[Homo sapiens]
Length = 1466
Score = 2538 bits (6579), Expect = 0.0
Identities = 1302/1432 (90%), Positives = 1319/1432 (92%), Gaps = 56/1432 (3%)
Query: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH
Sbjct: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
Query: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA
Sbjct: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
Query: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS
Sbjct: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
Query: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD
Sbjct: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
Query: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL
Sbjct: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
Query: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD
Sbjct: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
Query: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV
Sbjct: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
Query: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN
Sbjct: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
Query: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK
Sbjct: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
Query: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP
Sbjct: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
Query: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT
Sbjct: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
Query: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND 720
LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND
Sbjct: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND 720
Query: 721 SLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEK--------------TR 766
SLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEK R
Sbjct: 721 SLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLAR 780
Query: 767 ILVTHSMSY-----LPQVDVII--------------------VMSGGKISEMGSYQELLA 801
+ +++ Y L VD + ++ +S + ++
Sbjct: 781 AVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIV 840
Query: 802 RDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK--------- 852
G + +Y A + + +E ENG+ GK
Sbjct: 841 MSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGM 900
Query: 853 --------QLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKL 904
QLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKL
Sbjct: 901 LVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKL 960
Query: 905 SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYG 964
SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYG
Sbjct: 961 SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYG 1020
Query: 965 ALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKEL 1024
ALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKEL
Sbjct: 1021 ALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKEL 1080
Query: 1025 DTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQL 1084
DTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQL
Sbjct: 1081 DTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQL 1140
Query: 1085 KRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLA 1144
KRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLA
Sbjct: 1141 KRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLA 1200
Query: 1145 VRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVA 1204
VRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVA
Sbjct: 1201 VRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVA 1260
Query: 1205 VERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGG 1264
VERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGG
Sbjct: 1261 VERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGG 1320
Query: 1265 EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF 1324
EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF
Sbjct: 1321 EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF 1380
Query: 1325 SGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSV 1376
SGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENL V
Sbjct: 1381 SGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLRV 1432
Score = 95.9 bits (237), Expect = 3e-19
Identities = 96/375 (25%), Positives = 159/375 (42%), Gaps = 27/375 (7%)
Query: 1100 NETLLGVSVIR------AFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNC 1153
NE L G+ V++ AF+++ I Q +LKV + + AY ++ W+ V C
Sbjct: 506 NEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK-KSAYLSAVGTFTWVCTPF-LVALC 563
Query: 1154 IVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSE 1213
FA + + L A +S++ + LN L + S + V+++RL+ +
Sbjct: 564 T--FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLS 621
Query: 1214 TEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRT 1273
E+ P I E P + RN + L I +I G V +VG+
Sbjct: 622 HEELEPDSI-ERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQV 680
Query: 1274 GAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD 1333
G GKSSL L + EG + I G + +PQ + + SLR N+
Sbjct: 681 GCGKSSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRENIL 727
Query: 1334 PFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTK 1393
Q + + ++ L + LP E E G NLS GQ+Q V LARA+
Sbjct: 728 FGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNAD 787
Query: 1394 ILVLDEATAAVDLETDDLIQSTI---RTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQ 1450
I + D+ +AVD I + + ++ T + + H ++ + +IV+ G+I
Sbjct: 788 IYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKIS 847
Query: 1451 EYGAPSDLLQQRGLF 1465
E G+ +LL + G F
Sbjct: 848 EMGSYQELLARDGAF 862
Score = 73.6 bits (179), Expect = 1e-12
Identities = 36/36 (100%), Positives = 36/36 (100%)
Query: 1440 RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1475
RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV
Sbjct: 1431 RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1466
Score = 61.2 bits (147), Expect = 7e-09
Identities = 78/322 (24%), Positives = 128/322 (39%), Gaps = 42/322 (13%)
Query: 506 NEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK-KSAYLSAVGTFTWVCTPF-LVALC 563
NE L G+ V++ AF+++ I Q +LKV + + AY ++ W+ V C
Sbjct: 1156 NETLLGVSVIR------AFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNC 1209
Query: 564 T--FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLS 621
FA + + L A +S++ + LN L + S + V+++RL+ +
Sbjct: 1210 IVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSE 1269
Query: 622 HEELEPDSI-ERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQV 680
E+ P I E P + RN + L I +I G V +VG+
Sbjct: 1270 TEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRT 1329
Query: 681 GCGKSSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRENIL 727
G GKSSL L + EG + I G + +PQ + + SLR N+
Sbjct: 1330 GAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD 1389
Query: 728 FGCQLEEPYYRSVIQACALLPDLEILP---SGDRTEIGEKTRILVTHSMSYLPQVDVIIV 784
Q + + ++ L + LP + E GE R +IV
Sbjct: 1390 PFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLR---------------VIV 1434
Query: 785 MSGGKISEMGSYQELLARDGAF 806
+ G+I E G+ +LL + G F
Sbjct: 1435 LDKGEIQEYGAPSDLLQQRGLF 1456
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 1227 bits (3174), Expect = 0.0
Identities = 685/1545 (44%), Positives = 974/1545 (63%), Gaps = 110/1545 (7%)
Query: 22 WNTS-----NPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTA 76
WN+S D CF+ TVLVW+P +LW P+ L++ + T L K
Sbjct: 11 WNSSFLDSPEADLPLCFEQTVLVWIPLGFLWLLAPWQLLHVYKSRTKRSSTTKLYLAKQV 70
Query: 77 -LGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSS 135
+GFLL I+ +L E S + V +P+L T LL LIQ R+ VQ +
Sbjct: 71 FVGFLL-ILAAIELALVLTEDSGQATVPAVRYTNPSLYLGTWLLV-LLIQYSRQWCVQKN 128
Query: 136 GIMLT-FWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDR 194
L+ FW+++++C ++ I T L+ D +L F++ + ++ L+ S FS+
Sbjct: 129 SWFLSLFWILSILCGTFQFQTLIRTLLQGDNS-NLAYSCLFFISYGFQILILIFSAFSEN 187
Query: 195 SPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVV 254
+ + + P S ASFLS IT+ W +I++GY++PL D+W +++E ++ +V
Sbjct: 188 N--------ESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLV 239
Query: 255 PVLVKNWKKECAKTRK--QPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPS 312
+ K+E K R+ Q + S ++ + ++ +AL+++ +K+ S
Sbjct: 240 SKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKS 299
Query: 313 ----------LFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQ 362
L K L+KTF L SF K ++D+ F PQ+LKLLI F +D W
Sbjct: 300 GTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWI 359
Query: 363 GYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGE 422
GY +LLF A +Q+ L YF +CF G++++TA++ +VY+KAL ++N ARK TVGE
Sbjct: 360 GYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGE 419
Query: 423 IVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAV 482
VNLMSVDAQ+ MD+ +++M+WS+ LQ++L+++ LW LGPSVLAGV VMVL++P+NA+
Sbjct: 420 TVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAI 479
Query: 483 MAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKS 542
++ K+KT QV +MK+KD R+K+MNEIL+GIK+LK +AWE +F+D+V +R++ELK L
Sbjct: 480 LSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAF 539
Query: 543 AYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMV 602
+ L V F + TP LV++ TF+VYV +D NNILDAQ AF S+ LFNILRFPL++LPM+
Sbjct: 540 SQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMM 599
Query: 603 ISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLN 662
ISS++QASVS +RL +L ++L+ +I D ++ A+FTW T+
Sbjct: 600 ISSMLQASVSTERLEKYLGGDDLDTSAIRH----DCNFDKAMQFSEASFTWEHDSEATVR 655
Query: 663 GITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSL 722
+ I G LVAV+G VG GKSSL+SA+L EM+ V GH+ IKG+ AYVPQQ+WIQN ++
Sbjct: 656 DVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTI 715
Query: 723 RENILFGCQLEEPYYRSVIQACAL------LPDLEILPSGDR------------------ 758
++NILFG + E Y+ V++ACAL LP ++ G++
Sbjct: 716 KDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARAT 775
Query: 759 -----------------TEIGE---------------KTRILVTHSMSYLPQVDVIIVMS 786
+G+ KTR+LVTHSM +LPQVD I+V+
Sbjct: 776 YQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLG 835
Query: 787 GGKISEMGSYQELLARDGAFAEFLRTYAS-TEQEQDA-------EENGVTGVSGPGKEAK 838
G I E GSY LLA+ G FA+ L+T+ T E++A EE+ G+ +E
Sbjct: 836 NGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIP 895
Query: 839 QMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEET-----WKLME 893
E+ +T +R LS SS +G + ++ + + + KE+ KL++
Sbjct: 896 --EDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIK 953
Query: 894 ADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDP-IVNGT 952
+ +TG+VK S+Y +Y++AIGLF F I F+ N V+ + SN WLS WT D I N T
Sbjct: 954 KEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNST 1013
Query: 953 Q---EHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFE 1009
+R+ VYGALG++QGI VF + G + AS LH LL++ILR+PM FF+
Sbjct: 1014 DYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFD 1073
Query: 1010 RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLI 1069
TP+G +VNRF+ ++ TVD +P+ ++ ++ +I ++I +ATP+ II+ PLG+I
Sbjct: 1074 TTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGII 1133
Query: 1070 YFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDEN 1129
Y VQ FYV++SRQL+RL+SV+RSP+YSHF+ET+ G+ VIRAFE Q+RF+ +++++D N
Sbjct: 1134 YVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTN 1193
Query: 1130 QKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLN 1189
QK + I +NRWLA+RLE VGN V F+AL VI R +LS VG +S +L +T LN
Sbjct: 1194 QKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLN 1253
Query: 1190 WLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYRED 1249
WLVRM+SE+ETNIVAVER+ EY++ E EAPW + + PP WP G+++F NY +RYR +
Sbjct: 1254 WLVRMTSEIETNIVAVERITEYTKVENEAPW-VTDKRPPPDWPSKGKIQFNNYQVRYRPE 1312
Query: 1250 LDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHD 1309
LD VLR I I EK+G+VGRTGAGKSSLT LFRI E+A G+IIIDG++IA IGLHD
Sbjct: 1313 LDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHD 1372
Query: 1310 LRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAE 1369
LR K+TIIPQDP+LFSGSLRMNLDPF+ YSDEE+W +LELAHLK FV++L L HE E
Sbjct: 1373 LREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTE 1432
Query: 1370 GGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIA 1429
G NLS+GQRQL+CL RALLRK+KILVLDEATAAVDLETD+LIQ+TI+ +F CTV+TIA
Sbjct: 1433 AGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIA 1492
Query: 1430 HRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGL 1474
HRL+TIMD +V+VLD G+I E G+P +LLQ G FY MAK+AG+
Sbjct: 1493 HRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGI 1537
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 1119 bits (2894), Expect = 0.0
Identities = 638/1523 (41%), Positives = 907/1523 (59%), Gaps = 102/1523 (6%)
Query: 22 WNTSNPD------FTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKT 75
WN + P+ + CF T VWVP YLW P Y L++ H RGY++M+PL K K
Sbjct: 14 WNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGRGYLRMSPLFKAKM 73
Query: 76 ALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSS 135
LGF L ++C + + + W+ +G AP FL+ PT+ TM A FLI ER+KGVQSS
Sbjct: 74 VLGFALIVLCTSSVAVALWKIQQGTPEAPEFLIHPTVWLTTMSFAVFLIHTERKKGVQSS 133
Query: 136 GIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRS 195
G++ +WL+ C + + A Q D R ++ Y+ SL++ Q VLSC +D+
Sbjct: 134 GVLFGYWLL---CFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQFVLSCLADQP 190
Query: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
P F E NPCPE+ A+F S+ TFWW++GL+ RGYR+PL DLWSL +E++SE++V
Sbjct: 191 PFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVS 250
Query: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
L K W + + R+ + + K + K E E + + +W P L K
Sbjct: 251 RLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAP-------ETEPFL-RQEGSQWRP-LLK 301
Query: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTAC 375
+++ F FL+ I D+ F+ P++L L ++F+ D K P W+GY VL+F++AC
Sbjct: 302 AIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSAC 361
Query: 376 LQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFM 435
LQTL Q + V MR+++A+ G VYRK L +++ +RK+S VG++VNL+SVD QR
Sbjct: 362 LQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLT 421
Query: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
+ Y+N +W + +++ LW LGPS L +AV + ++P+N ++ K +Q M
Sbjct: 422 ESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQM 481
Query: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
+ KD+R +L + IL K +K + WE AF D+VL IR +EL L+ S L +V ++
Sbjct: 482 RQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQV 541
Query: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
+ FLVAL FAV+ + EN ++A+ AFV+L + NIL LP I S+VQA VS R
Sbjct: 542 STFLVALVVFAVHTLVAEN-AMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDR 600
Query: 616 LRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVA 675
L FL EE++P ++ G + IT+ +ATF W++ PP L+ I ++P+G L+A
Sbjct: 601 LVTFLCLEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLA 660
Query: 676 VVGQVGCGKSSLLSALLAEMDKVE------GHVAIKGSVAYVPQQA-------------- 715
VVG VG GKSSLLSALL E+ KVE G VA A+V +
Sbjct: 661 VVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPP 720
Query: 716 WIQN-----------DSLRENI----------LFGCQ-----LEEPYYRSVIQACALLPD 749
W++ DS E I L G Q L YR A LL D
Sbjct: 721 WLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKA--AVYLLDD 778
Query: 750 -LEILPS-----------GDRTEIGEKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQ 797
L L + G + TRILVTH++ LPQ D IIV++ G I+EMGSYQ
Sbjct: 779 PLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQ 838
Query: 798 ELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK--QLQ 855
ELL R GA L +Q + + G G + PG K SAG+ +L+
Sbjct: 839 ELLQRKGALVCLL------DQARQPGDRG-EGETEPGTSTKDPRG-----TSAGRRPELR 886
Query: 856 RQLSSSSSYSGDISRHHNSTAELQKA---EAKKEETWKLMEADKAQTGQVKLSVYWDYMK 912
R+ S S + +T+E Q + W + D Q G+VK +V+ Y++
Sbjct: 887 RERSIKS-----VPEKDRTTSEAQTEVPLDDPDRAGWPAGK-DSIQYGRVKATVHLAYLR 940
Query: 913 AIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGI 972
A+G + ++FLF+C V++ YWLSLW DDP V G Q +R ++G LG Q I
Sbjct: 941 AVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAI 1000
Query: 973 AVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIP 1032
+F AV +GG ASR L LL ++RSP+SFFERTP G+L+NRFSKE DTVD IP
Sbjct: 1001 GLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIP 1060
Query: 1033 EVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSR 1092
+ ++ + F ++ +V+ +ATP+A + I PL L+Y Q YV SS QL+RLES S
Sbjct: 1061 DKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASY 1120
Query: 1093 SPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGN 1152
S V SH ET G +V+RAF Q F+ Q++ +VDE+Q+ +P +VA+RWLA +E +GN
Sbjct: 1121 SSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGN 1180
Query: 1153 CIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYS 1212
+V AA AV+S+ LSAGLVG SVS +LQVT L W+VR +++E +IV+VER+++Y+
Sbjct: 1181 GLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYA 1240
Query: 1213 ETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGR 1272
T KEAPW++ A WPQ G++EFR++ LRYR +L ++ ++ I+ GEKVGIVGR
Sbjct: 1241 WTPKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGR 1300
Query: 1273 TGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL 1332
TGAGKSSL GL R+ E+AEG I IDG+ IA +GLH LR +I+IIPQDP+LF GSLRMNL
Sbjct: 1301 TGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNL 1360
Query: 1333 DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKT 1392
D ++SDE +W +LE LK V++LP +L ++CA+ GE+LSVGQ+QL+CLARALLRKT
Sbjct: 1361 DLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKT 1420
Query: 1393 KILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEY 1452
+IL+LDEATAAVD T+ +Q+ + + F CTVL IAHRL ++MD RV+V+DKG++ E
Sbjct: 1421 QILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAES 1480
Query: 1453 GAPSDLLQQRGLFYSMAKDAGLV 1475
G+P+ LL Q+GLFY +A+++GLV
Sbjct: 1481 GSPAQLLAQKGLFYRLAQESGLV 1503
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 987 bits (2552), Expect = 0.0
Identities = 566/1342 (42%), Positives = 810/1342 (60%), Gaps = 93/1342 (6%)
Query: 197 LFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPV 256
+F+ + NPCPE+ A+F S+ TFWW++GL+ RGYR+PL DLWSL +E++SE++V
Sbjct: 1 MFTFSTKYTNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSR 60
Query: 257 LVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKV 316
L K W + + R+ + + K + K E E + + +W P L K
Sbjct: 61 LEKEWMRNRSAARRHNKAIAFKRKGGSGMKAP-------ETEPFL-RQEGSQWRP-LLKA 111
Query: 317 LYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACL 376
+++ F FL+ I D+ F+ P++L L ++F+ D K P W+GY VL+F++ACL
Sbjct: 112 IWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACL 171
Query: 377 QTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMD 436
QTL Q + V MR+++A+ G VYRK L +++ +RK+S VG++VNL+SVD QR +
Sbjct: 172 QTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTE 231
Query: 437 LATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMK 496
Y+N +W + +++ LW LGPS L +AV + ++P+N ++ K +Q M+
Sbjct: 232 SVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMR 291
Query: 497 SKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCT 556
KD+R +L + IL K +K + WE AF D+VL IR +EL L+ S L +V ++ +
Sbjct: 292 QKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVS 351
Query: 557 PFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRL 616
FLVAL FAV+ + EN ++A+ AFV+L + NIL LP I S+VQA VS RL
Sbjct: 352 TFLVALVVFAVHTLVAEN-AMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRL 410
Query: 617 RIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAV 676
FL EE++P +++ G + IT+++ATF W++ PP L+ I ++P+G L+AV
Sbjct: 411 VTFLCLEEVDPGAVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAV 470
Query: 677 VGQVGCGKSSLLSALLAEMDKVE------GHVAIKGSVAYVPQQA--------------W 716
VG VG GKSSLLSALL E+ KVE G VA A+V + W
Sbjct: 471 VGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPW 530
Query: 717 IQN-----------DSLRENI----------LFGCQ-----LEEPYYRSVIQACALLPD- 749
++ DS E I L G Q L YR A LL D
Sbjct: 531 LERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKA--AVYLLDDP 588
Query: 750 LEILPS-----------GDRTEIGEKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQE 798
L L + G + TRILVTH++ LPQ D IIV++ G I+EMGSYQE
Sbjct: 589 LAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQE 648
Query: 799 LLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK--QLQR 856
LL R GA L +Q + + G G + PG K SAG+ +L+R
Sbjct: 649 LLQRKGALVCLL------DQARQPGDRG-EGETEPGTSTKDPRG-----TSAGRRPELRR 696
Query: 857 QLSSSSSYSGDISRHHNSTAELQKA---EAKKEETWKLMEADKAQTGQVKLSVYWDYMKA 913
+ S S + +T+E Q + W + D Q G+VK +V+ Y++A
Sbjct: 697 ERSIKS-----VPEKDRTTSEAQTEVPLDDPDRAGWPAGK-DSIQYGRVKATVHLAYLRA 750
Query: 914 IGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIA 973
+G + ++FLF+C V++ YWLSLW DDP V G Q +R ++G LG Q I
Sbjct: 751 VGTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIG 810
Query: 974 VFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPE 1033
+F AV +GG ASR L LL ++RSP+SFFERTP G+L+NRFSKE DTVD IP+
Sbjct: 811 LFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPD 870
Query: 1034 VIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRS 1093
++ + F ++ +V+ +ATP+A + I PL L+Y Q YV SS QL+RLES S S
Sbjct: 871 KLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYS 930
Query: 1094 PVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNC 1153
V SH ET G +V+RAF Q F+ Q++ +VDE+Q+ +P +VA+RWLA +E +GN
Sbjct: 931 SVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNG 990
Query: 1154 IVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSE 1213
+V AA AV+S+ LSAGLVG SVS +LQVT L W+VR +++E +IV+VER+++Y+
Sbjct: 991 LVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAW 1050
Query: 1214 TEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRT 1273
T KEAPW++ A WPQ G++EF+++ LRYR +L ++ ++ I+ GEKVGIVGRT
Sbjct: 1051 TPKEAPWRLPTCAAQPPWPQGGQIEFQDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRT 1110
Query: 1274 GAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD 1333
GAGKSSL GL R+ E+AEG I IDG+ IA +GLH LR +I+IIPQDP+LF GSLRMNLD
Sbjct: 1111 GAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLD 1170
Query: 1334 PFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTK 1393
++SDE +W +LE LK V++LP +L ++CA+ GE+LSVGQ+QL+CLARALLRKT+
Sbjct: 1171 LLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQ 1230
Query: 1394 ILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYG 1453
IL+LDEATAAVD T+ +Q+ + + F CTVL IAHRL ++MD RV+V+DKG++ E G
Sbjct: 1231 ILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESG 1290
Query: 1454 APSDLLQQRGLFYSMAKDAGLV 1475
+P+ LL Q+GLFY +A+++GLV
Sbjct: 1291 SPAQLLAQKGLFYRLAQESGLV 1312
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 836 bits (2160), Expect = 0.0
Identities = 416/757 (54%), Positives = 546/757 (72%), Gaps = 16/757 (2%)
Query: 8 SADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQM 67
S + WD N++ +T NPD T CFQN++L WVPC YLW P Y LYL H RGYI +
Sbjct: 7 SGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIIL 66
Query: 68 TPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLE 127
+ L+K K LG LLW V WADLFYSF G APVF V+P ++G+TMLLAT LIQ E
Sbjct: 67 SHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYE 126
Query: 128 RRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLV 187
R +GVQSSG+++ FW + +VCA+ RSKI+ A E D FR TFY++F+L+L L+
Sbjct: 127 RLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALI 186
Query: 188 LSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKE 247
L+CF ++ P FS DPNP PE+SA FLSR+ FWW T + + GYR PLE DLWSL +E
Sbjct: 187 LACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEE 246
Query: 248 DTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQK 307
D S+ VV L++ W+K+ +T + K A P ++ A+ E E L+ P+
Sbjct: 247 DRSQMVVQQLLEAWRKQEKQTARH--------KASAAPGKN----ASGEDEVLLGARPRP 294
Query: 308 EWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYT 367
PS K L TFG FL+S FK I DL+ F PQ+L +LI+F+++ AP W G+
Sbjct: 295 R-KPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVA 353
Query: 368 VLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLM 427
L+F+ + +Q+L+L Y+H FV+G++ +T ++G +YRKALVITNS +++STVGEIVNLM
Sbjct: 354 GLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLM 413
Query: 428 SVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKT 487
SVDAQRFMDLA ++N++WSAPLQ+ILA+Y LW NLGPSVLAGVA MVL++P+N +A+K
Sbjct: 414 SVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKM 473
Query: 488 KTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSA 547
+ +QV MK KD+RIKLM+EILNGIKVLKLYAWE +F +V IRQ EL++L+ +AYL
Sbjct: 474 RAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHT 533
Query: 548 VGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIV 607
TFTW+C+PFLV L T VYV +D NN+LDA+ AFVS++LFNILR PLN+LP +IS++
Sbjct: 534 TTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLT 593
Query: 608 QASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFS 667
QASVSLKR++ FLS EEL+P S+ER+ + G +IT+ + TFTWA+ PPTL+ +
Sbjct: 594 QASVSLKRIQQFLSQEELDPQSVERKTISPG---YAITIHSGTFTWAQDLPPTLHSLDIQ 650
Query: 668 IPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENIL 727
+P+GALVAVVG VGCGKSSL+SALL EM+K+EG V +KGSVAYVPQQAWIQN +L+EN+L
Sbjct: 651 VPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVL 710
Query: 728 FGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEK 764
FG L Y+ ++ACALL DLE+LP GD+TEIGEK
Sbjct: 711 FGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEK 747
Score = 808 bits (2087), Expect = 0.0
Identities = 416/734 (56%), Positives = 537/734 (73%), Gaps = 17/734 (2%)
Query: 756 GDRTEIGEKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYAS 815
G + KTR+LVTH +S+LPQ D IIV++ G++SEMG Y LL R+G+FA FL YA
Sbjct: 795 GPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAP 854
Query: 816 TEQEQDAEENGVTGVSGPGKEAKQMENGML----------VTDSAGKQLQRQLSSSSS-- 863
E + E++ KEA +E+ + VT KQ RQLS+ SS
Sbjct: 855 DEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDG 914
Query: 864 --YSGDISRHHNSTAE-LQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISF 920
+ R H +E +Q EAK + L + +KA G V+LSV+WDY KA+GL +
Sbjct: 915 EGQGRPVPRRHLGPSEKVQVTEAKADGA--LTQEEKAAIGTVELSVFWDYAKAVGLCTTL 972
Query: 921 LSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMA 980
L++ +A+ +N WLS WT+D + + Q +T +RL VY ALGI QG V +MA
Sbjct: 973 AICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMA 1032
Query: 981 VSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMG 1040
++ GGI A+R LH LLH+ +RSP SFF+ TPSG ++N FSK++ VD ++ VI M +
Sbjct: 1033 MAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLN 1092
Query: 1041 SLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFN 1100
S FN I +VI+ +TP+ ++I PL ++Y VQRFY A+SRQLKRLESVSRSP+YSHF+
Sbjct: 1093 SFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFS 1152
Query: 1101 ETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAAL 1160
ET+ G SVIRA+ F SD KVD NQ++ YP I++NRWL++ +E VGNC+VLFAAL
Sbjct: 1153 ETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAAL 1212
Query: 1161 FAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPW 1220
FAVI R SL+ GLVGLSVSYSLQVT LNW++RM S++E+NIVAVER+KEYS+TE EAPW
Sbjct: 1213 FAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPW 1272
Query: 1221 QIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSL 1280
++ + PP WP G VEFRNY +RYR LD VLR +++ ++GGEKVGIVGRTGAGKSS+
Sbjct: 1273 VVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSM 1332
Query: 1281 TLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSD 1340
TL LFRI E+A+GEI IDG+N+A IGLHDLR ++TIIPQDP+LFSG+LRMNLDPF YS+
Sbjct: 1333 TLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSE 1392
Query: 1341 EEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEA 1400
E++W +LEL+HL FVS+ P LD +C+EGGENLSVGQRQLVCLARALLRK++ILVLDEA
Sbjct: 1393 EDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEA 1452
Query: 1401 TAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQ 1460
TAA+DLETD+LIQ+TIRTQF+ CTVLTIAHRLNTIMDYTRV+VLDKG + E+ +P++L+
Sbjct: 1453 TAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIA 1512
Query: 1461 QRGLFYSMAKDAGL 1474
RG+FY MA+DAGL
Sbjct: 1513 ARGIFYGMARDAGL 1526
Score = 86.7 bits (213), Expect = 2e-16
Identities = 98/422 (23%), Positives = 178/422 (42%), Gaps = 36/422 (8%)
Query: 1052 ILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRA 1111
+L ++IP G + ++ F V +Q+K +S + +E L G+ V++
Sbjct: 452 VLAGVAFMVLLIPLNGAVAVKMRAFQV---KQMKLKDSRIKL-----MSEILNGIKVLKL 503
Query: 1112 FEEQERFIHQSD-LKVDENQ----KAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISR 1166
+ + F+ Q + ++ E Q AY + W+ + I L+ ++ V
Sbjct: 504 YAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPF--LVTLITLWVYVY-VDPN 560
Query: 1167 HSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETA 1226
+ L A +SVS + LN L ++ S + V+++R++++ E+ P ++
Sbjct: 561 NVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKT 620
Query: 1227 PPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFR 1286
+ + + + +DL L +++ + G V +VG G GKSSL L
Sbjct: 621 ISPGYA----ITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLG 676
Query: 1287 INESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTS 1346
E EG++ + G + +PQ + + +L+ N+ + + +
Sbjct: 677 EMEKLEGKVHMKG-------------SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQT 723
Query: 1347 LELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDL 1406
LE L + LP E E G NLS GQRQ V LARA+ I +LD+ +AVD
Sbjct: 724 LEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDS 783
Query: 1407 ETDDLIQSTI---RTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG 1463
I + T + + H ++ + +IVL G++ E G LLQ+ G
Sbjct: 784 HVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNG 843
Query: 1464 LF 1465
F
Sbjct: 844 SF 845
Score = 49.3 bits (116), Expect = 3e-05
Identities = 73/334 (21%), Positives = 132/334 (39%), Gaps = 26/334 (7%)
Query: 421 GEIVNLMSVDAQRFMD-LATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPV 479
G I+N S D + LA I M+ ++ I L ++ + + + + VL V
Sbjct: 1066 GRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLV 1125
Query: 480 NAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYA----WELAFKDKVLAIRQEE 535
A ++ + S+ +E + G V++ Y +E+ KV A ++
Sbjct: 1126 QRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSC 1185
Query: 536 LKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFP 595
+ + +LS F C AL FAV N L + SL + F
Sbjct: 1186 YPYIISNRWLSIGVEFVGNCVVLFAAL--FAVIGRSSLNPGLVGLSVSYSLQV----TFA 1239
Query: 596 LNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIE-RRPVKDGGGTNSITVRNATFTWA 654
LN + ++S + V+++R++ + E P +E RP + + RN + +
Sbjct: 1240 LNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYR 1299
Query: 655 RSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG-------- 706
L ++ + G V +VG+ G GKSS+ L ++ +G + I G
Sbjct: 1300 PGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGL 1359
Query: 707 -----SVAYVPQQAWIQNDSLRENI-LFGCQLEE 734
+ +PQ + + +LR N+ FG EE
Sbjct: 1360 HDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEE 1393
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 755 bits (1950), Expect = 0.0
Identities = 470/1354 (34%), Positives = 731/1354 (53%), Gaps = 155/1354 (11%)
Query: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
P++ E P P A+ SR+ FWW+ L G+++ LE D++S+ ED S+ +
Sbjct: 3 PVYQEV----KPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGE 58
Query: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
L W KE + K PSL +
Sbjct: 59 ELQGFWDKEVLRAENDAQK------------------------------------PSLTR 82
Query: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVN-----DTKAPDWQGYFYTVLL 370
+ K + +L+ F I + P L +I + D+ A + + TVL
Sbjct: 83 AIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLT 142
Query: 371 FVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVD 430
F T L ++ H YF+ +GMR++ A+ +YRKAL ++N A +T G+IVNL+S D
Sbjct: 143 FCTLIL-AILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSND 201
Query: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
+F + +++ +W+ PLQ I LLW+ +G S LAG+AV+++++P+ + +
Sbjct: 202 VNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSL 261
Query: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
+ D RI+ MNE++ GI+++K+YAWE +F + + +R++E+ + +S+ L +
Sbjct: 262 RSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNL 321
Query: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNIL-PMVISSIVQA 609
++ ++ TF YV + +++ A FV++ L+ +R + + P I + +A
Sbjct: 322 ASFFSASKIIVFVTFTTYVLL--GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA 379
Query: 610 SVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWAR-SDPPTLNGITFSI 668
VS++R++ FL +E+ +R G + V++ T W + S+ PTL G++F++
Sbjct: 380 IVSIRRIQTFLLLDEIS----QRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTV 435
Query: 669 PEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILF 728
G L+AVVG VG GKSSLLSA+L E+ G V++ G +AYV QQ W+ + +LR NILF
Sbjct: 436 RPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILF 495
Query: 729 GCQLEEPYYRSVIQACALLPDLEILPS------GDRTE---------------------- 760
G + E+ Y VI+ACAL DL++L GDR
Sbjct: 496 GKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADI 555
Query: 761 --------------------------IGEKTRILVTHSMSYLPQVDVIIVMSGGKISEMG 794
+ EK ILVTH + YL I+++ GK+ + G
Sbjct: 556 YLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKG 615
Query: 795 SYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQL 854
+Y E L F L+ +D EE+ V G + N
Sbjct: 616 TYTEFLKSGIDFGSLLK--------KDNEESEQPPVPG----TPTLRN------------ 651
Query: 855 QRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAI 914
R S SS +S SR L+ + + L E ++++ G+V Y +Y +A
Sbjct: 652 -RTFSESSVWSQQSSRPSLKDGALESQDTENVPV-TLSEENRSE-GKVGFQAYKNYFRAG 708
Query: 915 GLFISFLSIFLFMCNHVSALA---SNYWLSLWTD-----DPIVNGTQEHTKVRLSVYGAL 966
+I F IFL + N + +A ++WLS W + + VNG T+ +L + L
Sbjct: 709 AHWIVF--IFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTE-KLDLNWYL 765
Query: 967 GISQGIAV----FGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRF 1020
GI G+ V FG + ++ + +L +S+ LH + SIL++P+ FF+R P G ++NRF
Sbjct: 766 GIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRF 825
Query: 1021 SKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVAS 1080
SK++ +D ++P F+ +L V+G V + P AI + PLG+I+ F++R+++ +
Sbjct: 826 SKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLET 885
Query: 1081 SRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVAN 1140
SR +KRLES +RSPV+SH + +L G+ IRA++ +ER D D + +A++ + +
Sbjct: 886 SRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTS 945
Query: 1141 RWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMET 1200
RW AVRL+ + V+ A ++I +L AG VGL++SY+L + W VR S+E+E
Sbjct: 946 RWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVEN 1005
Query: 1201 NIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVT 1260
+++VER+ EY++ EKEAPW+ Q+ PP+ WP G + F N Y VL+H+
Sbjct: 1006 MMISVERVIEYTDLEKEAPWEYQKRPPPA-WPHEGVIIFDNVNFMYSPGGPLVLKHLTAL 1064
Query: 1261 INGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQD 1320
I EKVGIVGRTGAGKSSL LFR++E EG+I ID I +IGLHDLR K++IIPQ+
Sbjct: 1065 IKSQEKVGIVGRTGAGKSSLISALFRLSEP-EGKIWIDKILTTEIGLHDLRKKMSIIPQE 1123
Query: 1321 PVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQ 1380
PVLF+G++R NLDPF++++DEE+W +L+ LK+ + LP K+D E AE G N SVGQRQ
Sbjct: 1124 PVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQ 1183
Query: 1381 LVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTR 1440
LVCLARA+LRK +IL++DEATA VD TD+LIQ IR +F CTVLTIAHRLNTI+D +
Sbjct: 1184 LVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDK 1243
Query: 1441 VIVLDKGEIQEYGAPSDLLQQR-GLFYSMAKDAG 1473
++VLD G ++EY P LLQ + LFY M + G
Sbjct: 1244 IMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLG 1277
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 678 bits (1750), Expect = 0.0
Identities = 437/1355 (32%), Positives = 696/1355 (51%), Gaps = 167/1355 (12%)
Query: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 273
+ LS+ T+WW+ LI+ +++P+ DL ++ K + + V V C K
Sbjct: 221 NLLSKATYWWMNTLIISAHKKPI---DLKAIGKLPIAMRAVTNYV------CLK------ 265
Query: 274 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKA 333
DA EE + + P + PS++ +Y+ FG L+S F+
Sbjct: 266 ------------------DAYEEQKKKVADHPNR--TPSIWLAMYRAFGRPILLSSTFRY 305
Query: 334 IHDLMMFSGPQILKLLIKFVNDTKAPD----------------WQGYFYTVLLFVTACLQ 377
+ DL+ F+GP + +++ VN+T+ Y VLLF+ LQ
Sbjct: 306 LADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQ 365
Query: 378 TLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVDAQRFM 435
L +++ +G+ ++ A++ +Y K L ++ S + T+G+I NL++++ + M
Sbjct: 366 RTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLM 425
Query: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
+W+ P+Q+I+ + LL+ LG S L G AV+VL+ P+ +A K Q + +
Sbjct: 426 WFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTL 485
Query: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
R+K NEIL GIK+LKLYAWE F V R +EL LK A +++ F
Sbjct: 486 DYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAA 545
Query: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
P L TF + NN+ A+ AF SL+LF+IL PL +L V+ V+A +S+++
Sbjct: 546 IPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQK 604
Query: 616 LRIFLSHEELEPDSI---ERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGA 672
L FL +E+ DS E + ++ V N F+W S TL+ I IP G
Sbjct: 605 LNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVVTNGYFSWG-SGLATLSNIDIRIPTGQ 663
Query: 673 LVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG-----------------SVAYVPQQA 715
L +VGQVGCGKSSLL A+L EM +EG V SVAY Q+
Sbjct: 664 LTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKP 723
Query: 716 WIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEI---------------LPSGDRTE 760
W+ N ++ ENI FG + Y++V AC+L PD+++ L G R
Sbjct: 724 WLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQR 783
Query: 761 I-----------------------------------------GEKTRILVTHSMSYLPQV 779
I ++T +LVTH + YL
Sbjct: 784 ICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHA 843
Query: 780 DVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQ 839
D II M G + G+ +++ +D E +T + Q+Q+ E++ EA Q
Sbjct: 844 DWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMN-RQDQELEKD---------MEADQ 893
Query: 840 MENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQT 899
L+R+ + YS + E ++ E +++ M
Sbjct: 894 TT------------LERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDN---MSTVMRLR 938
Query: 900 GQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGT----QEH 955
++ W Y+ + G F+ L IF + H +A +YWL+ WT + +N T Q +
Sbjct: 939 TKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTY 998
Query: 956 TKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGN 1015
S+ GI + S+ V G+ A++ LH +LL+ I+ P+ FF+ TP G
Sbjct: 999 YVAGFSILCGAGIFLCLVT---SLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGL 1055
Query: 1016 LVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQR 1075
++NRFS + + +D IP ++ S + A +I ATP+ + + PLG+ ++F+Q+
Sbjct: 1056 ILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQK 1115
Query: 1076 FYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYP 1135
++ +S+ L+ L+ ++ P+ HF+ET G++ IRAF + RF + D N AY
Sbjct: 1116 YFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLF 1175
Query: 1136 SIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMS 1195
ANRWL VR + +G CIVL A++ ++ S ++GLVGL + Y+L +T YLNW+VR
Sbjct: 1176 LSAANRWLEVRTDYLGACIVLTASIASISG--SSNSGLVGLGLLYALTITNYLNWVVRNL 1233
Query: 1196 SEMETNIVAVERLKEYSETEKEA-PWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVL 1254
+++E + AV+++ + E E + + P WPQ G ++ + C+RY +L VL
Sbjct: 1234 ADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVL 1293
Query: 1255 RHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKI 1314
+H+ I G+KVGI GRTG+GKSSL+L FR+ + +G+I+IDGI+I+K+ LH LR ++
Sbjct: 1294 KHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRL 1353
Query: 1315 TIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENL 1374
+II QDP+LFSGS+R NLDP + +D+ +W +LE+A LK+ V +LP LD EGGEN
Sbjct: 1354 SIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENF 1413
Query: 1375 SVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNT 1434
SVGQRQL CLARA +RK+ IL++DEATA++D+ T++++Q + T F D TV+TIAHR+++
Sbjct: 1414 SVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSS 1473
Query: 1435 IMDYTRVIVLDKGEIQEYG-APSDLLQQRGLFYSM 1468
IMD V+V +G + E P+ L + GLF ++
Sbjct: 1474 IMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTL 1508
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 678 bits (1750), Expect = 0.0
Identities = 443/1393 (31%), Positives = 703/1393 (50%), Gaps = 203/1393 (14%)
Query: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 273
+ LS+ T+WW+ LI+ +++P+ DL ++ K + + V V C K
Sbjct: 221 NLLSKATYWWMNTLIISAHKKPI---DLKAIGKLPIAMRAVTNYV------CLK------ 265
Query: 274 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKA 333
DA EE + + P + PS++ +Y+ FG L+S F+
Sbjct: 266 ------------------DAYEEQKKKVADHPNR--TPSIWLAMYRAFGRPILLSSTFRY 305
Query: 334 IHDLMMFSGPQILKLLIKFVNDTKAPD----------------WQGYFYTVLLFVTACLQ 377
+ DL+ F+GP + +++ VN+T+ Y VLLF+ LQ
Sbjct: 306 LADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQ 365
Query: 378 TLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVDAQRFM 435
L +++ +G+ ++ A++ +Y K L ++ S + T+G+I NL++++ + M
Sbjct: 366 RTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLM 425
Query: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
+W+ P+Q+I+ + LL+ LG S L G AV+VL+ P+ +A K Q + +
Sbjct: 426 WFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTL 485
Query: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
R+K NEIL GIK+LKLYAWE F V R +EL LK A +++ F
Sbjct: 486 DYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAA 545
Query: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
P L TF + NN+ A+ AF SL+LF+IL PL +L V+ V+A +S+++
Sbjct: 546 IPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQK 604
Query: 616 LRIFLSHEELEPDS------------------IERRPV--KDGGGTN------------- 642
L FL +E+ DS ++ + + K G +
Sbjct: 605 LNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRP 664
Query: 643 ------SITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMD 696
+I V N F+W S TL+ I IP G L +VGQVGCGKSSLL A+L EM
Sbjct: 665 AETEDIAIKVTNGYFSWG-SGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQ 723
Query: 697 KVEGHVAIKG-----------------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRS 739
+EG V SVAY Q+ W+ N ++ ENI FG + Y++
Sbjct: 724 TLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKA 783
Query: 740 VIQACALLPDLEI---------------LPSGDRTEI----------------------- 761
V AC+L PD+++ L G R I
Sbjct: 784 VTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALD 843
Query: 762 ------------------GEKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARD 803
++T +LVTH + YL D II M G + G+ +++ +D
Sbjct: 844 IHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKD 903
Query: 804 GAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSS 863
E +T + Q+Q+ E++ EA Q L+R+ +
Sbjct: 904 VELYEHWKTLMN-RQDQELEKD---------MEADQTT------------LERKTLRRAM 941
Query: 864 YSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSI 923
YS + E ++ E +++ M ++ W Y+ + G F+ L I
Sbjct: 942 YSREAKAQMEDEDEEEEEEEDEDDN---MSTVMRLRTKMPWKTCWRYLTSGGFFLLILMI 998
Query: 924 FLFMCNHVSALASNYWLSLWTDDPIVNGT----QEHTKVRLSVYGALGISQGIAVFGYSM 979
F + H +A +YWL+ WT + +N T Q + S+ GI + S+
Sbjct: 999 FSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVT---SL 1055
Query: 980 AVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFM 1039
V G+ A++ LH +LL+ I+ P+ FF+ TP G ++NRFS + + +D IP ++
Sbjct: 1056 TVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLT 1115
Query: 1040 GSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHF 1099
S + A +I ATP+ + + PLG+ ++F+Q+++ +S+ L+ L+ ++ P+ HF
Sbjct: 1116 RSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHF 1175
Query: 1100 NETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAA 1159
+ET G++ IRAF + RF + D N AY ANRWL VR + +G CIVL A+
Sbjct: 1176 SETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTAS 1235
Query: 1160 LFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEA- 1218
+ ++ S ++GLVGL + Y+L +T YLNW+VR +++E + AV+++ + E E
Sbjct: 1236 IASISG--SSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENY 1293
Query: 1219 PWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKS 1278
+ + P WPQ G ++ + C+RY +L VL+H+ I G+KVGI GRTG+GKS
Sbjct: 1294 EGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKS 1353
Query: 1279 SLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQY 1338
SL+L FR+ + +G+I+IDGI+I+K+ LH LR +++II QDP+LFSGS+R NLDP +
Sbjct: 1354 SLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKC 1413
Query: 1339 SDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLD 1398
+D+ +W +LE+A LK+ V +LP LD EGGEN SVGQRQL CLARA +RK+ IL++D
Sbjct: 1414 TDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMD 1473
Query: 1399 EATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDL 1458
EATA++D+ T++++Q + T F D TV+TIAHR++TI+ VIV+ +G I EY P L
Sbjct: 1474 EATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESL 1533
Query: 1459 L-QQRGLFYSMAK 1470
L Q+ G+F S +
Sbjct: 1534 LAQENGVFASFVR 1546
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 674 bits (1739), Expect = 0.0
Identities = 447/1412 (31%), Positives = 703/1412 (49%), Gaps = 228/1412 (16%)
Query: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVK---NWKKECAKTRK 270
+ LS+ T+WW+ I +++P+ DL ++ K +P+ ++ N+++ C
Sbjct: 223 NLLSKGTYWWMNAFIKTAHKKPI---DLRAIGK-------LPIAMRALTNYQRLCEAFDA 272
Query: 271 QPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFF 330
Q K + ++ ++++ L FG ++S
Sbjct: 273 QVRKDIQGTQGAR----------------------------AIWQALSHAFGRRLVLSST 304
Query: 331 FKAIHDLMMFSGPQILKLLIKFV---NDTKAPDWQ---------------GYFYTVLLFV 372
F+ + DL+ F+GP + ++ + ND P Q Y VLLF+
Sbjct: 305 FRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFL 364
Query: 373 TACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVD 430
LQ L +++ +G+ ++ A+ +Y K + ++ S + T G+I NL+++D
Sbjct: 365 ALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAID 424
Query: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
+ M +W+ P+Q+I+ + LL+ LG S L G AV++L+ PV +A K
Sbjct: 425 TNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQA 484
Query: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
Q + ++ + R+K NE+L GIK+LKLYAWE F+ +V R++E+ L+ A +++
Sbjct: 485 QRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISI 544
Query: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQAS 610
F P L TF +V+ + AF SL+LF+IL PL +L V+ S V+A
Sbjct: 545 FMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKAL 604
Query: 611 VSLKRLRIFLSHEELEPDSI-----------------------ERRPVK----------- 636
VS+++L FLS E+ + +RP +
Sbjct: 605 VSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQ 664
Query: 637 ------DGGGTNS-ITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLS 689
DG N + + FTW PTL+ IT IP G L +VGQVGCGKSSLL
Sbjct: 665 SLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLL 724
Query: 690 ALLAEMDKVEGHV--------------------------AIKGSVAYVPQQAWIQNDSLR 723
A L EM KV G V +G VAY Q+ W+ N ++
Sbjct: 725 AALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVE 784
Query: 724 ENILFGCQLEEPYYRSVIQACALLPDLEILP---------------SGDRTEIG------ 762
ENI+F + Y+ VI+AC+L PD++ILP G R I
Sbjct: 785 ENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALY 844
Query: 763 -----------------------------------EKTRILVTHSMSYLPQVDVIIVMSG 787
++T +LVTH + YLP D II M
Sbjct: 845 QHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKD 904
Query: 788 GKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVT 847
G I G+ ++ + E +T + Q+Q+ E+ VT ++A + G
Sbjct: 905 GTIQREGTLKDFQRSECQLFEHWKTLMN-RQDQELEKETVTE-----RKATEPPQG---- 954
Query: 848 DSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVY 907
L R +SS D E ++ EA + E + + Q ++
Sbjct: 955 ------LSRAMSSRDGLLQD--------EEEEEEEAAESEEDDNLSSMLHQRAEIPWRAC 1000
Query: 908 WDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIV--------NGTQEHT--- 956
Y+ + G+ + L +F + H+ +A +YWL+ WTD + + +QE T
Sbjct: 1001 AKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQ 1060
Query: 957 ---KVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPS 1013
+ +V +LGI + S+ V G+ ++ LH LL+ I+ +PM FFE TP
Sbjct: 1061 TVYAMVFTVLCSLGI---VLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPL 1117
Query: 1014 GNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFV 1073
G+++NRFS + +T+D IP ++ S + A VI TP+ + + PL ++ +F+
Sbjct: 1118 GSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFI 1177
Query: 1074 QRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAY 1133
Q+++ +SR L++L+ ++ P+ SHF ET+ G++ IRAF + RF + D N A
Sbjct: 1178 QKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIAS 1237
Query: 1134 YPSIVANRWLAVRLECVGNCIVLFAALFAVIS--RHSLSAGLVGLSVSYSLQVTTYLNWL 1191
ANRWL VR+E +G C+VL AA+ ++ + LSAGLVGL ++Y+L V+ YLNW+
Sbjct: 1238 LFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWM 1297
Query: 1192 VRMSSEMETNIVAVERLKEYSETEKEA-PWQIQETAPPSSWPQVGRVEFRNYCLRYREDL 1250
VR ++ME + AV+R+ +TE E+ + + P +WP G+++ +N +RY L
Sbjct: 1298 VRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSL 1357
Query: 1251 DFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDL 1310
VL+H+N I G+K+GI GRTG+GKSS +L FR+ ++ EG IIIDGI+IAK+ LH L
Sbjct: 1358 KPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTL 1417
Query: 1311 RFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEG 1370
R +++II QDPVLFSG++R NLDP + SD +W +LE+A LK V ALP LD EG
Sbjct: 1418 RSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEG 1477
Query: 1371 GENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAH 1430
GEN S GQRQL CLARA +RKT I ++DEATA++D+ T++++Q + T F D TV+TIAH
Sbjct: 1478 GENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAH 1537
Query: 1431 RLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQR 1462
R++TI+ VIVL +G I E+ P LL ++
Sbjct: 1538 RVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
Score = 34.7 bits (78), Expect = 0.70
Identities = 17/54 (31%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 759 TEIGEKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR-DGAFAEFLR 811
T ++T + + H + + D++IV+ G I E ++LL+R D FA F+R
Sbjct: 1525 TAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFVR 1578
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 668 bits (1723), Expect = 0.0
Identities = 439/1391 (31%), Positives = 701/1391 (50%), Gaps = 203/1391 (14%)
Query: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 273
+ LS+ T+WW+ LI+ +++P+ DL ++ K + + V V C K
Sbjct: 221 NLLSKATYWWMNTLIISAHKKPI---DLKAIGKLPIAMRAVTNYV------CLK------ 265
Query: 274 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKA 333
DA EE + + P + PS++ +Y+ FG L+S F+
Sbjct: 266 ------------------DAYEEQKKKVADHPNR--TPSIWLAMYRAFGRPILLSSTFRY 305
Query: 334 IHDLMMFSGPQILKLLIKFVNDTKAPD----------------WQGYFYTVLLFVTACLQ 377
+ DL+ F+GP + +++ VN+T+ Y VLLF+ LQ
Sbjct: 306 LADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQ 365
Query: 378 TLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVDAQRFM 435
L +++ +G+ ++ A++ +Y K L ++ S + T+G+I NL++++ + M
Sbjct: 366 RTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLM 425
Query: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
+W+ P+Q+I+ + LL+ LG S L G AV+VL+ P+ +A K Q + +
Sbjct: 426 WFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTL 485
Query: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
R+K NEIL GIK+LKLYAWE F V R +EL LK A +++ F
Sbjct: 486 DYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAA 545
Query: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
P L TF + NN+ A+ AF SL+LF+IL PL +L V+ V+A +S+++
Sbjct: 546 IPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQK 604
Query: 616 LRIFLSHEELEPDS------------------IERRPV--KDGGGTN------------- 642
L FL +E+ DS ++ + + K G +
Sbjct: 605 LNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRP 664
Query: 643 ------SITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMD 696
+I V N F+W S TL+ I IP G L +VGQVGCGKSSLL A+L EM
Sbjct: 665 AETEDIAIKVTNGYFSWG-SGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQ 723
Query: 697 KVEGHVAIKG-----------------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRS 739
+EG V SVAY Q+ W+ N ++ ENI FG + Y++
Sbjct: 724 TLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKA 783
Query: 740 VIQACALLPDLEI---------------LPSGDRTEI----------------------- 761
V AC+L PD+++ L G R I
Sbjct: 784 VTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALD 843
Query: 762 ------------------GEKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARD 803
++T +LVTH + YL D II M G + G+ +++ +D
Sbjct: 844 IHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKD 903
Query: 804 GAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSS 863
E +T + Q+Q+ E++ EA Q L+R+ +
Sbjct: 904 VELYEHWKTLMN-RQDQELEKD---------MEADQTT------------LERKTLRRAM 941
Query: 864 YSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSI 923
YS + E ++ E +++ M ++ W Y+ + G F+ L I
Sbjct: 942 YSREAKAQMEDEDEEEEEEEDEDDN---MSTVMRLRTKMPWKTCWRYLTSGGFFLLILMI 998
Query: 924 FLFMCNHVSALASNYWLSLWTDDPIVNGT----QEHTKVRLSVYGALGISQGIAVFGYSM 979
F + H +A +YWL+ WT + +N T Q + S+ GI + S+
Sbjct: 999 FSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVT---SL 1055
Query: 980 AVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFM 1039
V G+ A++ LH +LL+ I+ P+ FF+ TP G ++NRFS + + +D IP ++
Sbjct: 1056 TVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLT 1115
Query: 1040 GSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHF 1099
S + A +I ATP+ + + PLG+ ++F+Q+++ +S+ L+ L+ ++ P+ HF
Sbjct: 1116 RSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHF 1175
Query: 1100 NETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAA 1159
+ET G++ IRAF + RF + D N AY ANRWL VR + +G CIVL A+
Sbjct: 1176 SETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTAS 1235
Query: 1160 LFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEA- 1218
+ ++ S ++GLVGL + Y+L +T YLNW+VR +++E + AV+++ + E E
Sbjct: 1236 IASISG--SSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENY 1293
Query: 1219 PWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKS 1278
+ + P WPQ G ++ + C+RY +L VL+H+ I G+KVGI GRTG+GKS
Sbjct: 1294 EGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKS 1353
Query: 1279 SLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQY 1338
SL+L FR+ + +G+I+IDGI+I+K+ LH LR +++II QDP+LFSGS+R NLDP +
Sbjct: 1354 SLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKC 1413
Query: 1339 SDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLD 1398
+D+ +W +LE+A LK+ V +LP LD EGGEN SVGQRQL CLARA +RK+ IL++D
Sbjct: 1414 TDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMD 1473
Query: 1399 EATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYG-APSD 1457
EATA++D+ T++++Q + T F D TV+TIAHR+++IMD V+V +G + E P+
Sbjct: 1474 EATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNL 1533
Query: 1458 LLQQRGLFYSM 1468
L + GLF ++
Sbjct: 1534 LAHKNGLFSTL 1544
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 619 bits (1596), Expect = e-177
Identities = 407/1277 (31%), Positives = 643/1277 (50%), Gaps = 177/1277 (13%)
Query: 306 QKEWNPS--LFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQG 363
Q W L++ LY FG +L K + ++ FSGP +L LL+ F+ + + P G
Sbjct: 221 QAHWQEGARLWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQEPLSHG 280
Query: 364 YFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEI 423
Y + L A L ++ +QY + + ++ + AV+ +Y KAL + S + GE
Sbjct: 281 LLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPSRPPT---GEA 337
Query: 424 VNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVM 483
+NL+ D++R ++ A + W PLQ+ + LYLL+ +G + + G+ + +L+VPVN V+
Sbjct: 338 LNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVI 397
Query: 484 AMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSA 543
A + ++ KD R+KL+ E+L+GI+V+K WE A +V A R EL L+
Sbjct: 398 ATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIK 457
Query: 544 YLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVI 603
YL A + W P ++++ F YV + L A F +LAL +L PLN P VI
Sbjct: 458 YLDAACVYLWAALPVVISIVIFITYVLMGHQ--LTATKVFTALALVRMLILPLNNFPWVI 515
Query: 604 SSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGG--------------TNSITVRNA 649
+ +++A VSL R+++FL P + G + + + A
Sbjct: 516 NGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPSTVLELHGA 575
Query: 650 TFTWARSDPPTLNGITF----SIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIK 705
F+W DP + TF + +G LV +VG+VGCGKSSLL+A+ E+ ++ GHVA++
Sbjct: 576 LFSW---DPVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVR 632
Query: 706 G---SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPS------- 755
G Q+ WIQ ++R+NILFG + Y+ V++ACAL DL ILP+
Sbjct: 633 GLSKGFGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVG 692
Query: 756 --------GDRTEIG-------EK--------------------------------TRIL 768
G R I EK TR+L
Sbjct: 693 EKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLL 752
Query: 769 VTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVT 828
TH YL + D +++M G++ G E+L A + A E Q+++
Sbjct: 753 CTHRTEYLERADAVLLMEAGRLIRAGPPSEILPLVQAVPK-----AWAENGQESDSATAQ 807
Query: 829 GVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEET 888
V P K + +E +++ L + E+KKE
Sbjct: 808 SVQNPEKTKEGLEE----------------------------EQSTSGRLLQEESKKE-- 837
Query: 889 WKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDD-P 947
G V L VY Y KA+G ++ +F + + A+++WLS W
Sbjct: 838 -----------GAVALHVYQAYWKAVGQGLALAILFSLLLMQATRNAADWWLSHWISQLK 886
Query: 948 IVNGTQE-----------------------------------------HTKVRLSVYGAL 966
N +QE + L+VY +
Sbjct: 887 AENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYATI 946
Query: 967 GISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDT 1026
+ ++ + G + A+ LH LLH +L +P++FF TP+G ++NRFS ++
Sbjct: 947 AGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVAC 1006
Query: 1027 VDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKR 1086
D +P ++ + + + ++G V+ P +++PPL ++Y+ VQR Y ASSR+L+R
Sbjct: 1007 ADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELRR 1066
Query: 1087 LESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVR 1146
L S++ SP+YSH +TL G+SV+RA RF ++ ++ NQ+ + + +WL +R
Sbjct: 1067 LGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLDIR 1126
Query: 1147 LECVGNCIVLFAALFAVISRHS--LSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVA 1204
L+ +G +V A A++ + GLVGLS+SY+L +T L+ LV ++ E +V+
Sbjct: 1127 LQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAMLVS 1186
Query: 1205 VERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGG 1264
VERL+EY+ + P Q Q + W G VEF++ L YR L L + + G
Sbjct: 1187 VERLEEYTCDLPQEP-QGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPG 1245
Query: 1265 EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF 1324
EK+GIVGRTG+GKSSL L LFR+ E + G +++DG++ +++ L LR ++ IIPQ+P LF
Sbjct: 1246 EKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLF 1305
Query: 1325 SGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCL 1384
SG++R NLDP + D +W +L+ HL + ++++ LD E EGG +LS+GQRQL+CL
Sbjct: 1306 SGTVRENLDPQGLHKDRALWQALKQCHLSEVITSM-GGLDGELGEGGRSLSLGQRQLLCL 1364
Query: 1385 ARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVL 1444
ARALL KIL +DEATA+VD +TD L+Q TI +F + TVLTIAHRLNTI++ RV+VL
Sbjct: 1365 ARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVL 1424
Query: 1445 DKGEIQEYGAPSDLLQQ 1461
G + E +P+ L Q
Sbjct: 1425 QAGRVVELDSPATLRNQ 1441
>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
Length = 1359
Score = 609 bits (1570), Expect = e-174
Identities = 414/1383 (29%), Positives = 676/1383 (48%), Gaps = 195/1383 (14%)
Query: 207 PCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECA 266
P P A LS TF W+T ++V+GYRQ L L L+ D+S+ W +E A
Sbjct: 43 PNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVA 102
Query: 267 KTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFL 326
+ P+K SL V++K L
Sbjct: 103 RV-----------------------------------GPEKA---SLSHVVWKFQRTRVL 124
Query: 327 MSFFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYF 385
M + +M GP IL +++ T W G + LF T + +
Sbjct: 125 MDIVANILCIIMAAIGPVILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAW 184
Query: 386 HICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIW 445
I + + +R+K A+ V+ +++ +VGE++N++S D+ + A + +
Sbjct: 185 AINYRTAIRLKVALSTLVFEN--LVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPA 242
Query: 446 SAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLM 505
+ P+ ++ + LGP+ L G++V V+ +PV MA ++ + + D R++ M
Sbjct: 243 TIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTM 302
Query: 506 NEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTF 565
NE L I+++K+YAWE +F + + IR+ E K+L+K+ ++ + + + + T
Sbjct: 303 NEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTL 362
Query: 566 AVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEEL 625
+ ++ + L A AF +A+FN+++F + ILP I ++ +A+VSL+R++ L +
Sbjct: 363 SCHILLRRK--LTAPVAFSVIAMFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKS- 419
Query: 626 EPDSIERRPVKDGGGTNSITVRNATFTW-----------------------------ARS 656
P S +P + + NAT TW +
Sbjct: 420 -PPSYITQPEDPD---TVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSER 475
Query: 657 DPPT----------------LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEG 700
PP L+ I+F + +G ++ + G VG GKSSLL+ALL +M +G
Sbjct: 476 SPPAKGATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKG 535
Query: 701 HVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILP------ 754
VA+ G++AYV QQAWI + ++RENILFG + + Y+ ++ C L DL LP
Sbjct: 536 VVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTE 595
Query: 755 ---------SGDRTEIG---------------------------------------EKTR 766
G R I KT
Sbjct: 596 IGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTV 655
Query: 767 ILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENG 826
+LVTH + +L D +I++ G+I E G+++EL+ G +A+ + Q +D E
Sbjct: 656 VLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGL-QFKDPEHLY 714
Query: 827 VTGVSGPGKEA---KQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEA 883
+ KE+ ++ + G++V ++ + + S + S D
Sbjct: 715 NAAMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDT--------------- 759
Query: 884 KKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFI-SFLSIFLFMCNHVSALASNYWLSL 942
K +L++ + Q G V Y Y+KA G ++ S ++FLF+ SA SN+WL L
Sbjct: 760 -KVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGL 818
Query: 943 WTDD-------PIVNGTQEHTKVRLSVYGA---LGISQGIAVFGYSMAVSIGGI------ 986
W D P N T L+ G + VF V+ G +
Sbjct: 819 WLDKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTL 878
Query: 987 LASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVI 1046
+AS LH + IL+SPMSFF+ TP+G L+NRFSK++D +D +P + F+ F V+
Sbjct: 879 MASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVV 938
Query: 1047 GACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGV 1106
+++ P +++ L + +F + R + ++LK++E+VSRSP ++H ++ G+
Sbjct: 939 FILVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGL 998
Query: 1107 SVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISR 1166
+I A+ ++E I L + A RW A+R++ + N + AL +S
Sbjct: 999 GIIHAYGKKESCITYHLLYFN----------CALRWFALRMDVLMNILTFTVALLVTLSF 1048
Query: 1167 HSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQIQET 1225
S+S GLS+SY +Q++ L VR +E + +VE L+EY T E ++
Sbjct: 1049 SSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKVG 1108
Query: 1226 APPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLF 1285
P WP G + FR+Y +RYR++ VL +N+ I G+ VGIVGRTG+GKSSL + LF
Sbjct: 1109 TCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALF 1168
Query: 1286 RINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWT 1345
R+ E A G I ID ++I + L DLR K+T+IPQDPVLF G++R NLDPF ++DE +W
Sbjct: 1169 RLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQ 1228
Query: 1346 SLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVD 1405
LE ++D + LP+KL E E GEN SVG+RQL+C+ARALLR +KI++LDEATA++D
Sbjct: 1229 VLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMD 1288
Query: 1406 LETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLF 1465
+TD L+Q+TI+ F+ CTVLTIAHRLNT+++ V+V++ G++ E+ P L ++
Sbjct: 1289 SKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSA 1348
Query: 1466 YSM 1468
++M
Sbjct: 1349 FAM 1351
>gi|221316556 ATP-binding cassette, sub-family C, member 3 isoform 2
[Homo sapiens]
Length = 572
Score = 589 bits (1518), Expect = e-168
Identities = 292/557 (52%), Positives = 387/557 (69%), Gaps = 13/557 (2%)
Query: 8 SADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQM 67
S + WD N++ +T NPD T CFQN++L WVPC YLW P Y LYL H RGYI +
Sbjct: 7 SGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIIL 66
Query: 68 TPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLE 127
+ L+K K LG LLW V WADLFYSF G APVF V+P ++G+TMLLAT LIQ E
Sbjct: 67 SHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYE 126
Query: 128 RRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLV 187
R +GVQSSG+++ FW + +VCA+ RSKI+ A E D FR TFY++F+L+L L+
Sbjct: 127 RLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALI 186
Query: 188 LSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKE 247
L+CF ++ P FS DPNP PE+SA FLSR+ FWW T + + GYR PLE DLWSL +E
Sbjct: 187 LACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEE 246
Query: 248 DTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQK 307
D S+ VV L++ W+K+ +T + K A P ++ A+ E E L+ P+
Sbjct: 247 DRSQMVVQQLLEAWRKQEKQTARH--------KASAAPGKN----ASGEDEVLLGARPRP 294
Query: 308 EWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYT 367
PS K L TFG FL+S FK I DL+ F PQ+L +LI+F+++ AP W G+
Sbjct: 295 R-KPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVA 353
Query: 368 VLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLM 427
L+F+ + +Q+L+L Y+H FV+G++ +T ++G +YRKALVITNS +++STVGEIVNLM
Sbjct: 354 GLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLM 413
Query: 428 SVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKT 487
SVDAQRFMDLA ++N++WSAPLQ+ILA+Y LW NLGPSVLAGVA MVL++P+N +A+K
Sbjct: 414 SVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKM 473
Query: 488 KTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSA 547
+ +QV MK KD+RIKLM+EILNGIKVLKLYAWE +F +V IRQ EL++L+ +AYL
Sbjct: 474 RAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHT 533
Query: 548 VGTFTWVCTPFLVALCT 564
TFTW+C+PFLV L T
Sbjct: 534 TTTFTWMCSPFLVRLGT 550
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 546 bits (1408), Expect = e-155
Identities = 333/881 (37%), Positives = 484/881 (54%), Gaps = 104/881 (11%)
Query: 660 TLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQN 719
TL+ I I EG LV + G VG GK+SL+SA+L +M +EG +AI G+ AYV QQAWI N
Sbjct: 577 TLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILN 636
Query: 720 DSLRENILFGCQLEEPYYRSVIQACALLPDLEI---------------LPSGDRTEIG-- 762
+LR+NILFG + +E Y SV+ +C L PDL I L G R I
Sbjct: 637 ATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLA 696
Query: 763 -------------------------------------EKTRILVTHSMSYLPQVDVIIVM 785
KT + VTH + YL D +I M
Sbjct: 697 RALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFM 756
Query: 786 SGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGML 845
G I+E G+++EL+ +G +A E E N SG K+++
Sbjct: 757 KEGCITERGTHEELMNLNGDYATIFNNLLLGETPP-VEINSKKETSGSQKKSQ------- 808
Query: 846 VTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLS 905
D K T ++K +A K E +L++ ++ G V S
Sbjct: 809 --DKGPK----------------------TGSVKKEKAVKPEEGQLVQLEEKGQGSVPWS 844
Query: 906 VYWDYMKAIGLFISFLSIF-LFMCNHVSALASNYWLSLWTDDPIVNGTQ---EHTKVRLS 961
VY Y++A G ++FL I LFM N S S +WLS W N T T V S
Sbjct: 845 VYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVSDS 904
Query: 962 VYGALGISQGIAVFGYSMAVSI------------GGILASRCLHVDLLHSILRSPMSFFE 1009
+ + +++ SMAV + G + AS LH +L ILRSPM FF+
Sbjct: 905 MKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFD 964
Query: 1010 RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLI 1069
TP+G ++NRFSK++D VD +P +MF+ ++ V +I P + + PL ++
Sbjct: 965 TTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVIL 1024
Query: 1070 YFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDEN 1129
+ + R+LKRL+++++SP SH ++ G++ I A+ + + F+H+ +D+N
Sbjct: 1025 FSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDN 1084
Query: 1130 QKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLN 1189
Q ++ A RWLAVRL+ + ++ L V+ + GL++SY++Q+T
Sbjct: 1085 QAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQ 1144
Query: 1190 WLVRMSSEMETNIVAVERLKEYSET-EKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYRE 1248
+ VR++SE E +VER+ Y +T EAP +I+ AP WPQ G V F N +RYRE
Sbjct: 1145 FTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRE 1204
Query: 1249 DLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLH 1308
+L VL+ ++ TI EK+GIVGRTG+GKSSL + LFR+ E + G I IDG+ I+ IGL
Sbjct: 1205 NLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLA 1264
Query: 1309 DLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECA 1368
DLR K++IIPQ+PVLFSG++R NLDPF+QY+++++W +LE H+K+ ++ LP KL+ E
Sbjct: 1265 DLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVM 1324
Query: 1369 EGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTI 1428
E G+N SVG+RQL+C+ARALLR KIL+LDEATAA+D ETD LIQ TIR F DCT+LTI
Sbjct: 1325 ENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTI 1384
Query: 1429 AHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL-QQRGLFYSM 1468
AHRL+T++ R++VL +G++ E+ PS LL FY+M
Sbjct: 1385 AHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAM 1425
Score = 146 bits (369), Expect = 1e-34
Identities = 113/450 (25%), Positives = 210/450 (46%), Gaps = 49/450 (10%)
Query: 209 PESSASFLSRITFWWITGLIVRGYRQ-PLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAK 267
P +A S +TF W++ L +++ L D+WSL+K ++S+ L + W++E +
Sbjct: 100 PVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNE 159
Query: 268 TRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLM 327
D A SL +V++ ++
Sbjct: 160 V----------GPDAA----------------------------SLRRVVWIFCRTRLIL 181
Query: 328 SFFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFH 386
S I L FSGP + K L+++ T++ + L +T +++ L +
Sbjct: 182 SIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWA 241
Query: 387 ICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWS 446
+ + +G+R++ A++ ++K L + N KS +GE++N+ S D QR + A +++
Sbjct: 242 LNYRTGVRLRGAILTMAFKKILKLKNIKEKS--LGELINICSNDGQRMFEAAAVGSLLAG 299
Query: 447 APLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMN 506
P+ IL + + LGP+ G AV +L P + T ++ + + D R++ MN
Sbjct: 300 GPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMN 359
Query: 507 EILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFA 566
E+L IK +K+YAW AF V IR+EE ++L+K+ Y ++ + ++ TF+
Sbjct: 360 EVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFS 419
Query: 567 VYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELE 626
V++T+ + L A AF + +FN + F L + P + S+ +ASV++ R + EE+
Sbjct: 420 VHMTLGFD--LTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVH 477
Query: 627 PDSIERRPVKDGGGTNSITVRNATFTWARS 656
I+ +P I ++NAT W S
Sbjct: 478 --MIKNKPASP---HIKIEMKNATLAWDSS 502
Score = 90.1 bits (222), Expect = 1e-17
Identities = 66/215 (30%), Positives = 99/215 (46%), Gaps = 14/215 (6%)
Query: 1250 LDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHD 1309
L L I++ I G+ VGI G G+GK+SL + EG I I G
Sbjct: 574 LQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISG---------- 623
Query: 1310 LRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAE 1369
+ Q + + +LR N+ +Y +E + L L+ ++ LP E E
Sbjct: 624 ---TFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGE 680
Query: 1370 GGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTI 1428
G NLS GQRQ + LARAL I +LD+ +A+D + + S IR + TVL +
Sbjct: 681 RGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFV 740
Query: 1429 AHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG 1463
H+L ++D VI + +G I E G +L+ G
Sbjct: 741 THQLQYLVDCDEVIFMKEGCITERGTHEELMNLNG 775
Score = 50.8 bits (120), Expect = 9e-06
Identities = 83/448 (18%), Positives = 177/448 (39%), Gaps = 56/448 (12%)
Query: 366 YTVLLFVTACLQTLVLHQYFHICFVSG-MRIKTAVIGAVYRKALVITNSARKSSTVGEIV 424
Y ++ + L+L + FV G +R + + ++R+ L ++ G I+
Sbjct: 913 YYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRIL 972
Query: 425 NLMSVDAQRFMDLATYINMIWSAPL---QVILALYLLWLNLG--PSVLAGVAVMVLMVPV 479
N S D + + + A + VIL + + + G P L V +V++ V
Sbjct: 973 NRFSKDMDE-----VDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSV 1027
Query: 480 NAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNGIKVLK-LYAWELAFKDKVLAIRQEEL 536
+++ + +K DN + ++ I + I+ L ++A+ K + R +EL
Sbjct: 1028 LHIVSRVL----IRELKRLDNITQSPFLSHITSSIQGLATIHAYN---KGQEFLHRYQEL 1080
Query: 537 KVLKKSAYLSAVGTFTWVCTPF----LVALCTFAVYVTIDENNILDAQTAFV---SLALF 589
++ + W+ + + T + + + I A ++ L
Sbjct: 1081 LDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLT 1140
Query: 590 NILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELE-PDSIERR-PVKDGGGTNSITVR 647
+ +F + + S S++R+ ++ LE P I+ + P D +T
Sbjct: 1141 GLFQFTVRLA----SETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFE 1196
Query: 648 NATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG- 706
NA + + P L ++F+I + +VG+ G GKSSL AL ++ G + I G
Sbjct: 1197 NAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGV 1256
Query: 707 ------------SVAYVPQQAWIQNDSLRENI---------LFGCQLEEPYYRSVIQACA 745
++ +PQ+ + + ++R N+ LE + + I
Sbjct: 1257 RISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLP 1316
Query: 746 LLPDLEILPSGDRTEIGEKTRILVTHSM 773
L + E++ +GD +GE+ + + ++
Sbjct: 1317 LKLESEVMENGDNFSVGERQLLCIARAL 1344
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 527 bits (1358), Expect = e-149
Identities = 375/1374 (27%), Positives = 642/1374 (46%), Gaps = 194/1374 (14%)
Query: 205 PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264
P P P +A S +T W+T L+++ R L+ + + L+ D S++ V L + W++E
Sbjct: 81 PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140
Query: 265 CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324
++ + V+ L++ Q+ +F L G
Sbjct: 141 VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172
Query: 325 FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384
F ++ I I+ ++++ + G LF++ C+++L
Sbjct: 173 FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223
Query: 385 FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444
+ I + +R + AV + K + + +S GE ++ + D + Y ++
Sbjct: 224 WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281
Query: 445 WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504
+++ + +G + + +L+ P+ M Q + D RI++
Sbjct: 282 LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341
Query: 505 MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564
+E+L IK++K+Y WE F + +R++E K+L+K + ++ + T P +
Sbjct: 342 TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVW 401
Query: 565 FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEE 624
++ ++ L A AF LA N+LR + +P+ + + + ++ R + F E
Sbjct: 402 VLIHTSLKLK--LTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQES 459
Query: 625 LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG--------------------- 663
+ ++D + ++ AT +W ++ P +NG
Sbjct: 460 ---PVFYVQTLQDP--SKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDAL 514
Query: 664 ---------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSV 708
I + +G ++ V G G GKSSLLSA+L EM +EG V ++GS+
Sbjct: 515 GPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSL 574
Query: 709 AYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEI---------------L 753
AYVPQQAWI + ++RENIL G ++ Y V+ C+L DLE+ L
Sbjct: 575 AYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNL 634
Query: 754 PSGDRTEIG---------------------------------------EKTRILVTHSMS 774
G + I KT +LVTH +
Sbjct: 635 SGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQ 694
Query: 775 YLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQDAEENGVTGVS 831
YL II++ GKI E G++ EL+ + G +A+ ++ A+++ QD +
Sbjct: 695 YLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIA----- 749
Query: 832 GPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKL 891
E ++E+ L T S S +G+ H T E
Sbjct: 750 ----EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE-------------- 780
Query: 892 MEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVS-ALASNYWLSLWTDDPIVN 950
++ + G + VY Y++A G ++ IF F+ V + S +WLS W +
Sbjct: 781 ---EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGT 837
Query: 951 GTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL------ASRCLHV 994
+ + ++ G + + ++ V+G + + V GI AS LH
Sbjct: 838 NSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHN 897
Query: 995 DLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILL 1054
L + + R PMSFF+ P G L+N F+ +L+ +D ++P + F+ VI +++ +
Sbjct: 898 KLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSV 957
Query: 1055 ATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEE 1114
+P ++ + +I F + + KRLE+ SRSP++SH +L G+S I + +
Sbjct: 958 LSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGK 1017
Query: 1115 QERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLV 1174
E FI Q D + + RW+A+RLE + N + L ALF S
Sbjct: 1018 TEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFK 1077
Query: 1175 GLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQIQETAPPSSWPQ 1233
++V+ LQ+ + R+ E E AVER+ +Y + EAP ++ T+ P WPQ
Sbjct: 1078 VMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQ 1137
Query: 1234 VGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEG 1293
G + F++Y ++YR++ VL IN+TI G E VGIVGRTG+GKSSL + LFR+ E G
Sbjct: 1138 HGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
Query: 1294 EIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLK 1353
I+IDG++I IGL DLR K+++IPQDPVL SG++R NLDPF +++D+++W +LE L
Sbjct: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLT 1257
Query: 1354 DFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQ 1413
+S P KL + E G N SVG+RQL+C+ARA+LR +KI+++DEATA++D+ETD LIQ
Sbjct: 1258 KAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQ 1317
Query: 1414 STIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYS 1467
TIR F+ CTVL IAHR+ T+++ ++V+ G++ E+ P L ++ G ++
Sbjct: 1318 RTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFA 1371
Score = 90.9 bits (224), Expect = 8e-18
Identities = 65/224 (29%), Positives = 105/224 (46%), Gaps = 18/224 (8%)
Query: 1254 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1313
L IN+ ++ G +G+ G TG+GKSSL + EG + + G
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
Query: 1314 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1373
+ +PQ + SG++R N+ Y L L + LP E E G N
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633
Query: 1374 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTIAHRL 1432
LS GQ+Q + LARA+ +I +LD+ +AVD + + I+ TV+ + H+L
Sbjct: 634 LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693
Query: 1433 NTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG----LFYSMAKDA 1472
+ ++I+L+ G+I E G S+L+Q++G L M K+A
Sbjct: 694 QYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA 737
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 527 bits (1358), Expect = e-149
Identities = 375/1374 (27%), Positives = 642/1374 (46%), Gaps = 194/1374 (14%)
Query: 205 PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264
P P P +A S +T W+T L+++ R L+ + + L+ D S++ V L + W++E
Sbjct: 81 PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140
Query: 265 CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324
++ + V+ L++ Q+ +F L G
Sbjct: 141 VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172
Query: 325 FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384
F ++ I I+ ++++ + G LF++ C+++L
Sbjct: 173 FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223
Query: 385 FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444
+ I + +R + AV + K + + +S GE ++ + D + Y ++
Sbjct: 224 WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281
Query: 445 WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504
+++ + +G + + +L+ P+ M Q + D RI++
Sbjct: 282 LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341
Query: 505 MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564
+E+L IK++K+Y WE F + +R++E K+L+K + ++ + T P +
Sbjct: 342 TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVW 401
Query: 565 FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEE 624
++ ++ L A AF LA N+LR + +P+ + + + ++ R + F E
Sbjct: 402 VLIHTSLKLK--LTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQES 459
Query: 625 LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG--------------------- 663
+ ++D + ++ AT +W ++ P +NG
Sbjct: 460 ---PVFYVQTLQDP--SKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDAL 514
Query: 664 ---------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSV 708
I + +G ++ V G G GKSSLLSA+L EM +EG V ++GS+
Sbjct: 515 GPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSL 574
Query: 709 AYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEI---------------L 753
AYVPQQAWI + ++RENIL G ++ Y V+ C+L DLE+ L
Sbjct: 575 AYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNL 634
Query: 754 PSGDRTEIG---------------------------------------EKTRILVTHSMS 774
G + I KT +LVTH +
Sbjct: 635 SGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQ 694
Query: 775 YLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQDAEENGVTGVS 831
YL II++ GKI E G++ EL+ + G +A+ ++ A+++ QD +
Sbjct: 695 YLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIA----- 749
Query: 832 GPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKL 891
E ++E+ L T S S +G+ H T E
Sbjct: 750 ----EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE-------------- 780
Query: 892 MEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVS-ALASNYWLSLWTDDPIVN 950
++ + G + VY Y++A G ++ IF F+ V + S +WLS W +
Sbjct: 781 ---EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGT 837
Query: 951 GTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL------ASRCLHV 994
+ + ++ G + + ++ V+G + + V GI AS LH
Sbjct: 838 NSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHN 897
Query: 995 DLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILL 1054
L + + R PMSFF+ P G L+N F+ +L+ +D ++P + F+ VI +++ +
Sbjct: 898 KLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSV 957
Query: 1055 ATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEE 1114
+P ++ + +I F + + KRLE+ SRSP++SH +L G+S I + +
Sbjct: 958 LSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGK 1017
Query: 1115 QERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLV 1174
E FI Q D + + RW+A+RLE + N + L ALF S
Sbjct: 1018 TEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFK 1077
Query: 1175 GLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQIQETAPPSSWPQ 1233
++V+ LQ+ + R+ E E AVER+ +Y + EAP ++ T+ P WPQ
Sbjct: 1078 VMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQ 1137
Query: 1234 VGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEG 1293
G + F++Y ++YR++ VL IN+TI G E VGIVGRTG+GKSSL + LFR+ E G
Sbjct: 1138 HGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
Query: 1294 EIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLK 1353
I+IDG++I IGL DLR K+++IPQDPVL SG++R NLDPF +++D+++W +LE L
Sbjct: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLT 1257
Query: 1354 DFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQ 1413
+S P KL + E G N SVG+RQL+C+ARA+LR +KI+++DEATA++D+ETD LIQ
Sbjct: 1258 KAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQ 1317
Query: 1414 STIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYS 1467
TIR F+ CTVL IAHR+ T+++ ++V+ G++ E+ P L ++ G ++
Sbjct: 1318 RTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFA 1371
Score = 90.9 bits (224), Expect = 8e-18
Identities = 65/224 (29%), Positives = 105/224 (46%), Gaps = 18/224 (8%)
Query: 1254 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1313
L IN+ ++ G +G+ G TG+GKSSL + EG + + G
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
Query: 1314 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1373
+ +PQ + SG++R N+ Y L L + LP E E G N
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633
Query: 1374 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTIAHRL 1432
LS GQ+Q + LARA+ +I +LD+ +AVD + + I+ TV+ + H+L
Sbjct: 634 LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693
Query: 1433 NTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG----LFYSMAKDA 1472
+ ++I+L+ G+I E G S+L+Q++G L M K+A
Sbjct: 694 QYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA 737
>gi|21729876 ATP-binding cassette, sub-family C, member 11 isoform b
[Homo sapiens]
Length = 1344
Score = 470 bits (1209), Expect = e-132
Identities = 357/1374 (25%), Positives = 617/1374 (44%), Gaps = 232/1374 (16%)
Query: 205 PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264
P P P +A S +T W+T L+++ R L+ + + L+ D S++ V L + W++E
Sbjct: 81 PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140
Query: 265 CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324
++ + V+ L++ Q+ +F L G
Sbjct: 141 VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172
Query: 325 FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384
F ++ I I+ ++++ + G LF++ C+++L
Sbjct: 173 FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223
Query: 385 FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444
+ I + +R + AV + K + + +S GE ++ + D + Y ++
Sbjct: 224 WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281
Query: 445 WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504
+++ + +G + + +L+ P+ M Q + D RI++
Sbjct: 282 LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341
Query: 505 MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564
+E+L IK++K+Y WE F + +R++E K+L+K + ++ + T P +
Sbjct: 342 TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVW 401
Query: 565 FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEE 624
++ ++ L A AF LA N+LR + +P+ + + + ++ R + F E
Sbjct: 402 VLIHTSLKLK--LTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQES 459
Query: 625 LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG--------------------- 663
+ ++D + ++ AT +W ++ P +NG
Sbjct: 460 ---PVFYVQTLQDP--SKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDAL 514
Query: 664 ---------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSV 708
I + +G ++ V G G GKSSLLSA+L EM +EG V ++GS+
Sbjct: 515 GPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSL 574
Query: 709 AYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEI---------------L 753
AYVPQQAWI + ++RENIL G ++ Y V+ C+L DLE+ L
Sbjct: 575 AYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNL 634
Query: 754 PSGDRTEIG---------------------------------------EKTRILVTHSMS 774
G + I KT +LVTH +
Sbjct: 635 SGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQ 694
Query: 775 YLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQDAEENGVTGVS 831
YL II++ GKI E G++ EL+ + G +A+ ++ A+++ QD +
Sbjct: 695 YLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIA----- 749
Query: 832 GPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKL 891
E ++E+ L T S S +G+ H T E
Sbjct: 750 ----EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE-------------- 780
Query: 892 MEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVS-ALASNYWLSLWTDDPIVN 950
++ + G + VY Y++A G ++ IF F+ V + S +WLS W +
Sbjct: 781 ---EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGT 837
Query: 951 GTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL------ASRCLHV 994
+ + ++ G + + ++ V+G + + V GI AS LH
Sbjct: 838 NSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHN 897
Query: 995 DLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILL 1054
L + + R PMSFF+ P G L+N F+ +L+ +D ++P + F+ VI +++ +
Sbjct: 898 KLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSV 957
Query: 1055 ATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEE 1114
+P ++ + +I F + + KRLE+ SRSP++SH +L G+S I + +
Sbjct: 958 LSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGK 1017
Query: 1115 QERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLV 1174
E FI Q D + + RW+A+RLE + N + L ALF S
Sbjct: 1018 TEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFK 1077
Query: 1175 GLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQIQETAPPSSWPQ 1233
++V+ LQ+ + R+ E E AVER+ +Y + EAP ++ T+ P WPQ
Sbjct: 1078 VMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQ 1137
Query: 1234 VGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEG 1293
G + F++Y ++YR++ VL IN+TI G E VGIVGRTG+GKSSL + LFR+ E G
Sbjct: 1138 HGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
Query: 1294 EIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLK 1353
I+IDG++I IGL DLR K+++IPQDPVL SG++R NLDPF +++D+++W +LE
Sbjct: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALE----- 1252
Query: 1354 DFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQ 1413
R L K I+++DEATA++D+ETD LIQ
Sbjct: 1253 --------------------------------RTFLTKA-IILIDEATASIDMETDTLIQ 1279
Query: 1414 STIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYS 1467
TIR F+ CTVL IAHR+ T+++ ++V+ G++ E+ P L ++ G ++
Sbjct: 1280 RTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFA 1333
Score = 90.9 bits (224), Expect = 8e-18
Identities = 65/224 (29%), Positives = 105/224 (46%), Gaps = 18/224 (8%)
Query: 1254 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1313
L IN+ ++ G +G+ G TG+GKSSL + EG + + G
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
Query: 1314 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1373
+ +PQ + SG++R N+ Y L L + LP E E G N
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633
Query: 1374 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTIAHRL 1432
LS GQ+Q + LARA+ +I +LD+ +AVD + + I+ TV+ + H+L
Sbjct: 634 LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693
Query: 1433 NTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG----LFYSMAKDA 1472
+ ++I+L+ G+I E G S+L+Q++G L M K+A
Sbjct: 694 QYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA 737
Score = 48.1 bits (113), Expect = 6e-05
Identities = 92/474 (19%), Positives = 188/474 (39%), Gaps = 72/474 (15%)
Query: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVIL 453
+ TA+ ++ K S + +G ++N + D ++ L + + +++
Sbjct: 890 KASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVI 949
Query: 454 ALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNG 511
A+ L+ L P +L A+++++ + +M K + K +N R L + ILN
Sbjct: 950 AVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKA----IGVFKRLENYSRSPLFSHILNS 1005
Query: 512 IKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTI 571
++ L + + K + + + L + + L + + W+ A+ + I
Sbjct: 1006 LQGLS--SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWM-----------ALRLEI 1052
Query: 572 DENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIE 631
N + A FV+ F I P + M ++ ++Q + S + E + ++E
Sbjct: 1053 MTNLVTLAVALFVA---FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVE 1109
Query: 632 R-----------RPVKDGGGT--------NSITVRNATFTWARSDPPTLNGITFSIPEGA 672
R P+ G + I ++ + + P L+GI +I
Sbjct: 1110 RILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHE 1169
Query: 673 LVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQN 719
+V +VG+ G GKSSL AL ++ + G + I G ++ +PQ + +
Sbjct: 1170 VVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLS 1229
Query: 720 DSLRENI-----LFGCQLEEPYYRSVIQACALLPDLEILPSGD-----------RTEIGE 763
++R N+ Q+ + R+ + +L D E S D R
Sbjct: 1230 GTIRFNLDPFDRHTDQQIWDALERTFLTKAIILID-EATASIDMETDTLIQRTIREAFQG 1288
Query: 764 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGA-FAEFLRTYAST 816
T +++ H ++ + D I+VM GK+ E + L + G+ FA + T S+
Sbjct: 1289 CTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS 1342
>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
[Homo sapiens]
Length = 859
Score = 340 bits (872), Expect = 6e-93
Identities = 251/904 (27%), Positives = 432/904 (47%), Gaps = 136/904 (15%)
Query: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
P++ E P P A+ SR+ FWW+ L G+++ LE D++S+ ED S+ +
Sbjct: 3 PVYQEV----KPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGE 58
Query: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
L W KE + K PSL +
Sbjct: 59 ELQGFWDKEVLRAENDAQK------------------------------------PSLTR 82
Query: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVN-----DTKAPDWQGYFYTVLL 370
+ K + +L+ F I + P L +I + D+ A + + TVL
Sbjct: 83 AIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLT 142
Query: 371 FVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVD 430
F T L ++ H YF+ +GMR++ A+ +YRKAL ++N A +T G+IVNL+S D
Sbjct: 143 FCTLIL-AILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSND 201
Query: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
+F + +++ +W+ PLQ I LLW+ +G S LAG+AV+++++P+ + +
Sbjct: 202 VNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSL 261
Query: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
+ D RI+ MNE++ GI+++K+YAWE +F + + +R++E+ + +S+ L +
Sbjct: 262 RSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNL 321
Query: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNI-LPMVISSIVQA 609
++ ++ TF YV + +++ A FV++ L+ +R + + P I + +A
Sbjct: 322 ASFFSASKIIVFVTFTTYVLL--GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA 379
Query: 610 SVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWAR-SDPPTLNGITFSI 668
VS++R++ FL +E+ +R G + V++ T W + S+ PTL G++F++
Sbjct: 380 IVSIRRIQTFLLLDEIS----QRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTV 435
Query: 669 PEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILF 728
G L+AVVG VG GKSSLLSA+L E+ G V++ G +AYV QQ W+ + +LR NILF
Sbjct: 436 RPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILF 495
Query: 729 GCQLEEPYYRSVIQACALLPDLEILPSGDRTEI---------GEKTRILVTHSM------ 773
G + E+ Y VI+ACAL DL++L GD T I G+K R+ + ++
Sbjct: 496 GKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADI 555
Query: 774 ----SYLPQVDV------------------IIVMSGGKISEMGSYQELL-------ARDG 804
L VD I ++ ++ + + ++L + G
Sbjct: 556 YLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKG 615
Query: 805 AFAEFLRTYA--STEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSS 862
+ EFL++ + ++D EE+ V G + N S Q Q S S
Sbjct: 616 TYTEFLKSGIDFGSLLKKDNEESEQPPVPG----TPTLRNRTFSESSVWSQ---QSSRPS 668
Query: 863 SYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLS 922
G + + +E + E G+V Y +Y +A +I F
Sbjct: 669 LKDGALESQDTENVPVTLSEENRSE------------GKVGFQAYKNYFRAGAHWIVF-- 714
Query: 923 IFLFMCN---HVSALASNYWLSLWTD-----DPIVNGTQEHTKVRLSVYGALGISQGIAV 974
IFL + N V+ + ++WLS W + + VNG T+ +L + LGI G+ V
Sbjct: 715 IFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTE-KLDLNWYLGIYSGLTV 773
Query: 975 ----FGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVD 1028
FG + ++ + +L +S+ LH + SIL++P+ FF+R P G ++NRFSK++ +D
Sbjct: 774 ATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLD 833
Query: 1029 SMIP 1032
++P
Sbjct: 834 DLLP 837
Score = 83.2 bits (204), Expect = 2e-15
Identities = 106/489 (21%), Positives = 204/489 (41%), Gaps = 32/489 (6%)
Query: 992 LHVDLLHSILRSPMSFFE----RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIG 1047
L V + H I R + +T +G +VN S +++ D + + ++ G L I
Sbjct: 166 LRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPL-QAIA 224
Query: 1048 ACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVS 1107
++ + I+ + + +I +Q + L+ + NE + G+
Sbjct: 225 VTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIR 284
Query: 1108 VIRAFEEQERFIHQ-SDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISR 1166
+I+ + ++ F + ++L+ E K S + LA IV V+
Sbjct: 285 IIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSA-SKIIVFVTFTTYVLLG 343
Query: 1167 HSLSAGLVGLSVSY----SLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQI 1222
++A V ++V+ L VT + + SE IV++ R++ + ++ + Q
Sbjct: 344 SVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA---IVSIRRIQTFLLLDEIS--QR 398
Query: 1223 QETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTL 1282
P V +F + + E L+ ++ T+ GE + +VG GAGKSSL
Sbjct: 399 NRQLPSDGKKMVHVQDFTAFWDKASETP--TLQGLSFTVRPGELLAVVGPVGAGKSSLLS 456
Query: 1283 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEE 1342
+ + G + + G +I + Q P +FSG+LR N+ +Y E
Sbjct: 457 AVLGELAPSHGLVSVHG-------------RIAYVSQQPWVFSGTLRSNILFGKKYEKER 503
Query: 1343 VWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATA 1402
++ LK + L D + G LS GQ+ V LARA+ + I +LD+ +
Sbjct: 504 YEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLS 563
Query: 1403 AVDLETD-DLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1461
AVD E L + I + + + H+L + +++++L G++ + G ++ L+
Sbjct: 564 AVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKS 623
Query: 1462 RGLFYSMAK 1470
F S+ K
Sbjct: 624 GIDFGSLLK 632
>gi|90421313 cystic fibrosis transmembrane conductance regulator [Homo
sapiens]
Length = 1480
Score = 276 bits (706), Expect = 1e-73
Identities = 159/524 (30%), Positives = 287/524 (54%), Gaps = 24/524 (4%)
Query: 963 YGALGISQGIAVFGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRF 1020
Y +G++ + G+ + + L S+ LH +LHS+L++PMS +G ++NRF
Sbjct: 917 YIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRF 976
Query: 1021 SKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVAS 1080
SK++ +D ++P I F+ L VIGA V+ + P + P+ + + ++ +++ +
Sbjct: 977 SKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQT 1036
Query: 1081 SRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVAN 1140
S+QLK+LES RSP+++H +L G+ +RAF Q F ++ + ++ +
Sbjct: 1037 SQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTL 1096
Query: 1141 RWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMET 1200
RW +R+E + I A F I G VG+ ++ ++ + + L W V S ++++
Sbjct: 1097 RWFQMRIEMIF-VIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDS 1155
Query: 1201 NIVAVERLKEYSETEKEAPWQIQETAPPSS-------------------WPQVGRVEFRN 1241
+ +V R+ ++ + E + T P + WP G++ ++
Sbjct: 1156 LMRSVSRVFKFIDMPTEGK-PTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKD 1214
Query: 1242 YCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGIN 1301
+Y E + +L +I+ +I+ G++VG++GRTG+GKS+L R+ + EGEI IDG++
Sbjct: 1215 LTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EGEIQIDGVS 1273
Query: 1302 IAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPD 1361
I L R +IPQ +FSG+ R NLDP+ Q+SD+E+W + L+ + P
Sbjct: 1274 WDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPG 1333
Query: 1362 KLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFE 1421
KLD +GG LS G +QL+CLAR++L K KIL+LDE +A +D T +I+ T++ F
Sbjct: 1334 KLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFA 1393
Query: 1422 DCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLF 1465
DCTV+ HR+ +++ + +V+++ ++++Y + LL +R LF
Sbjct: 1394 DCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLF 1437
Score = 184 bits (468), Expect = 4e-46
Identities = 153/707 (21%), Positives = 281/707 (39%), Gaps = 138/707 (19%)
Query: 209 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKT 268
P AS +S++ F W ++ +GYRQ LE SD++ + D+++ + L + W +E A
Sbjct: 5 PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASK 64
Query: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328
+ NP L L + F F+
Sbjct: 65 K----------------------------------------NPKLINALRRCFFWRFMFY 84
Query: 329 FFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHI 387
F + ++ P +L +++ + D K + + L + ++TL+LH
Sbjct: 85 GIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFG 144
Query: 388 CFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSA 447
GM+++ A+ +Y+K L +++ ++G++V+L+S + +F + + +W A
Sbjct: 145 LHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIA 204
Query: 448 PLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNE 507
PLQV L + L+W L S G+ ++++ A + Y+ R+ + +E
Sbjct: 205 PLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSE 264
Query: 508 ILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAV 567
++ I+ +K Y WE A + + +RQ ELK+ +K+AY+ + + + F V +
Sbjct: 265 MIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLP 324
Query: 568 YVTIDENNILDAQTAFVSLALFNILRFPLNI-LPMVISSIVQASVSLKRLRIFLSHEELE 626
Y I + + F +++ +LR + P + + + ++ +++ FL +E
Sbjct: 325 YALIKG---IILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEY- 380
Query: 627 PDSIERRPVKDGGGTNSITVRNATFTWARS------------------------------ 656
+ ++ T + + N T W
Sbjct: 381 ------KTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFS 434
Query: 657 --DPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQ 714
P L I F I G L+AV G G GK+SLL ++ E++ EG + G +++ Q
Sbjct: 435 LLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQF 494
Query: 715 AWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLE---------------ILPSGDRT 759
+WI +++ENI+FG +E YRSVI+AC L D+ L G R
Sbjct: 495 SWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRA 554
Query: 760 EIG---------------------------------------EKTRILVTHSMSYLPQVD 780
I KTRILVT M +L + D
Sbjct: 555 RISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKAD 614
Query: 781 VIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGV 827
I+++ G G++ EL F+ L S +Q N +
Sbjct: 615 KILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSI 661
Score = 72.4 bits (176), Expect = 3e-12
Identities = 51/207 (24%), Positives = 100/207 (48%), Gaps = 14/207 (6%)
Query: 1253 VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRF 1312
VL+ IN I G+ + + G TGAGK+SL + + E +EG+I G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
Query: 1313 KITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGE 1372
+I+ Q + G+++ N+ Y + + ++ L++ +S +K + EGG
Sbjct: 487 RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGI 546
Query: 1373 NLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETD-DLIQSTIRTQFEDCTVLTIAHR 1431
LS GQR + LARA+ + + +LD +D+ T+ ++ +S + + T + + +
Sbjct: 547 TLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSK 606
Query: 1432 LNTIMDYTRVIVLDKGEIQEYGAPSDL 1458
+ + ++++L +G YG S+L
Sbjct: 607 MEHLKKADKILILHEGSSYFYGTFSEL 633
Score = 47.4 bits (111), Expect = 1e-04
Identities = 32/115 (27%), Positives = 57/115 (49%), Gaps = 16/115 (13%)
Query: 625 LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGK 684
+E +++ + GG +TV++ T + L I+FSI G V ++G+ G GK
Sbjct: 1193 IENSHVKKDDIWPSGG--QMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGK 1250
Query: 685 SSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRENI 726
S+LLSA L ++ EG + I G + +PQ+ +I + + R+N+
Sbjct: 1251 STLLSAFLRLLN-TEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNL 1304
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 184 bits (467), Expect = 5e-46
Identities = 209/936 (22%), Positives = 392/936 (41%), Gaps = 136/936 (14%)
Query: 628 DSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSS 686
DS + K ++ RN F++ +R + L G+ + G VA+VG GCGKS+
Sbjct: 376 DSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKST 435
Query: 687 LLSALLAEMDKVEGHVAIKGS-------------VAYVPQQAWIQNDSLRENILFG---- 729
+ + D EG V++ G + V Q+ + ++ ENI +G
Sbjct: 436 TVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENV 495
Query: 730 ---------------------------------CQLEEPYYRSVIQACALLPDLEILPSG 756
QL + + A AL+ + +IL
Sbjct: 496 TMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD 555
Query: 757 DRTEIGE-----------------KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQEL 799
+ T + +T I++ H +S + DVI G I E G++ EL
Sbjct: 556 EATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDEL 615
Query: 800 LARDGAFAEFLRTYAS---TEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQR 856
+ G + + + + E E A+E+ E +E M DS +++
Sbjct: 616 MKEKGIYFKLVTMQTAGNEVELENAADESK--------SEIDALE--MSSNDSRSSLIRK 665
Query: 857 QLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGL 916
+ + S ST E W++M+ + + W Y +G+
Sbjct: 666 RSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTE---------WPYF-VVGV 715
Query: 917 FISFLSIFLFMCNHVSALASNYWLSLWT--DDPIVNGTQEHTKVRLSVYGALGISQGIAV 974
F + ++ L A+ + + ++T DDP ++++ + ++ ALGI I
Sbjct: 716 FCAIINGGL---QPAFAIIFSKIIGVFTRIDDPETK--RQNSNLFSLLFLALGIISFITF 770
Query: 975 FGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFE--RTPSGNLVNRFSKELDTVDSMIP 1032
F G + ++ L + S+LR +S+F+ + +G L R + + V I
Sbjct: 771 FLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIG 830
Query: 1033 EVIKMFMGSLFNVIGACIVILL----ATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLE 1088
+ + ++ N+ I+ + T + I+P + + V + S + LK +
Sbjct: 831 SRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAG--VVEMKMLSGQALKDKK 888
Query: 1089 SVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQ--SDLKV---DENQKAYYPSIVANRWL 1143
+ S + E + + + ++++F H L+V + +KA+ I +
Sbjct: 889 ELEGSGKIA--TEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQ 946
Query: 1144 AVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSL----QVTTYLNWLVRMSSEME 1199
A+ C A L A LV +V + QV+++ +
Sbjct: 947 AMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAA 1006
Query: 1200 TNIVAVER---LKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLR 1255
I+ +E+ + YS TE P ++ G V F Y D VL+
Sbjct: 1007 HIIMIIEKTPLIDSYS-TEGLMPNTLE-----------GNVTFGEVVFNYPTRPDIPVLQ 1054
Query: 1256 HINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKIT 1315
+++ + G+ + +VG +G GKS++ L R + G++++DG I ++ + LR +
Sbjct: 1055 GLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLG 1114
Query: 1316 IIPQDPVLFSGSLRMNL---DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGE 1372
I+ Q+P+LF S+ N+ D S EE+ + + A++ F+ +LP+K + + G
Sbjct: 1115 IVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGT 1174
Query: 1373 NLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRL 1432
LS GQ+Q + +ARAL+R+ IL+LDEAT+A+D E++ ++Q + E T + IAHRL
Sbjct: 1175 QLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRL 1234
Query: 1433 NTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1468
+TI + ++V G ++E+G LL Q+G+++SM
Sbjct: 1235 STIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1270
Score = 155 bits (392), Expect = 3e-37
Identities = 138/522 (26%), Positives = 249/522 (47%), Gaps = 36/522 (6%)
Query: 967 GISQGIAVFGYSMAVSIGGILASRCLHV---DLLHSILRSPMSFFERTPSGNLVNRFSKE 1023
GI G+ V Y + VS + A R +H H+I+R + +F+ G L R + +
Sbjct: 120 GIGAGVLVAAY-IQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDD 178
Query: 1024 LDTVDSMIPEVIKMFMGSLFNVIGACIVILL----ATPIAAIIIPPLGLIYFFVQRFYVA 1079
+ ++ I + I MF S+ IV T + I P LGL + +
Sbjct: 179 VSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAK--IL 236
Query: 1080 SSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQK-AYYPSIV 1138
SS K L + +++ + E L + + AF Q++ + + + ++E ++ +I
Sbjct: 237 SSFTDKELLAYAKAGAVA--EEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAIT 294
Query: 1139 ANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVG-------LSVSYSLQVTTYLNWL 1191
AN +G +L A +A+ + + L G L+V +S+ + +
Sbjct: 295 AN-------ISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQ 347
Query: 1192 VRMSSEMETNI--VAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRY--R 1247
S E N A E K + P + G +EFRN Y R
Sbjct: 348 ASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNI---KGNLEFRNVHFSYPSR 404
Query: 1248 EDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGL 1307
+++ +L+ +N+ + G+ V +VG +G GKS+ + R+ + EG + +DG +I I +
Sbjct: 405 KEVK-ILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINV 463
Query: 1308 HDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYSDEEVWTSLELAHLKDFVSALPDKLDHE 1366
LR I ++ Q+PVLF+ ++ N+ + +E+ +++ A+ DF+ LP K D
Sbjct: 464 RFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTL 523
Query: 1367 CAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVL 1426
E G LS GQ+Q + +ARAL+R KIL+LDEAT+A+D E++ ++Q + + T +
Sbjct: 524 VGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTI 583
Query: 1427 TIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1468
IAHRL+T+ + + D G I E G +L++++G+++ +
Sbjct: 584 VIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKL 625
Score = 65.1 bits (157), Expect = 5e-10
Identities = 97/481 (20%), Positives = 179/481 (37%), Gaps = 109/481 (22%)
Query: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSV-LAGVAVMVLMVPV 479
G I + ++V Q +L T I + + Q L LL L + P + +AGV M ++
Sbjct: 827 GAIGSRLAVITQNIANLGTGIIISFIYGWQ----LTLLLLAIVPIIAIAGVVEMKML--- 879
Query: 480 NAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELK-V 538
+ A+K K K + K+ E + + + E F+ Q +
Sbjct: 880 -SGQALKDK-------KELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNS 931
Query: 539 LKKSAYLSAVGTFTWVCTPFLVALC-TFAVYVTIDENNILDAQTAFVSLALFNILRFPLN 597
L+K+ +FT F A C F Y+ + + S +F
Sbjct: 932 LRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGA------ 985
Query: 598 ILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTN---------SITVRN 648
M + + + + +I +H + IE+ P+ D T ++T
Sbjct: 986 ---MAVGQVSSFAPDYAKAKISAAHIIM---IIEKTPLIDSYSTEGLMPNTLEGNVTFGE 1039
Query: 649 ATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGS 707
F + R D P L G++ + +G +A+VG GCGKS+++ L D + G V + G
Sbjct: 1040 VVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGK 1099
Query: 708 -------------VAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACA---LLPDLE 751
+ V Q+ + + S+ ENI +G +++A + +E
Sbjct: 1100 EIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIE 1159
Query: 752 ILPSGDRTEIGEK----------------------------------------------- 764
LP+ T++G+K
Sbjct: 1160 SLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD 1219
Query: 765 ------TRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQ 818
T I++ H +S + D+I+V G++ E G++Q+LLA+ G + + A T++
Sbjct: 1220 KAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTKR 1279
Query: 819 E 819
+
Sbjct: 1280 Q 1280
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 177 bits (449), Expect = 7e-44
Identities = 143/488 (29%), Positives = 238/488 (48%), Gaps = 21/488 (4%)
Query: 992 LHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIK--MFMGSLFNVIGAC 1049
L L SILR ++FF++T +G L+NR S + + + E + + G+ +V G
Sbjct: 247 LRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASV-GIS 305
Query: 1050 IVILLATPIAAII---IPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGV 1106
++ ++ +A + +PP+ +I R+ R+L ++ S + E + V
Sbjct: 306 MMFFVSPNLATFVLSVVPPVSIIAVIYGRYL----RKLTKVTQDSLAQATQLAEERIGNV 361
Query: 1107 SVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFA---V 1163
+RAF ++ I + KVD + A GN IVL + L+ +
Sbjct: 362 RTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVL-SVLYKGGLL 420
Query: 1164 ISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQ 1223
+ ++ G + + Y+ V + L SE+ + A RL E E E + P+
Sbjct: 421 MGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEG 480
Query: 1224 ETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTL 1282
S+ G +EF+N Y + + + +++I G +VG +G+GKS++
Sbjct: 481 VILNEKSFQ--GALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLS 538
Query: 1283 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL----DPFSQY 1338
L R+ + A G I +DG +I ++ LR KI + Q+P+LFS S+ N+ D S
Sbjct: 539 LLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSV 598
Query: 1339 SDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLD 1398
+ EE+ E+A+ F+ P + E G LS GQ+Q + +ARALL+ KIL+LD
Sbjct: 599 TAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLD 658
Query: 1399 EATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDL 1458
EAT+A+D E + L+Q + + TVL IAHRL+TI + V VLD+G+I EYG +L
Sbjct: 659 EATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEEL 718
Query: 1459 LQQRGLFY 1466
L + Y
Sbjct: 719 LSKPNGIY 726
Score = 61.2 bits (147), Expect = 7e-09
Identities = 93/493 (18%), Positives = 189/493 (38%), Gaps = 101/493 (20%)
Query: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRF-MDLATYINMIWSAPLQVI 452
R++T++ ++ R+ + + R GE++N +S D + ++ A Q
Sbjct: 246 RLRTSLFSSILRQEVAFFDKTR----TGELINRLSSDTALLGRSVTENLSDGLRAGAQAS 301
Query: 453 LALYLLWL---NLGPSVLAGVA-VMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEI 508
+ + +++ NL VL+ V V ++ V + TK Q S +L E
Sbjct: 302 VGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQ----DSLAQATQLAEER 357
Query: 509 LNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSA--------VGTFTWVCTPFLV 560
+ ++ ++ + E+ +K + +++ +K A+ A G + +
Sbjct: 358 IGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKG 417
Query: 561 ALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFL 620
L + ++T+ E + +V +++ + F S +++ + RL L
Sbjct: 418 GLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSF--------YSELMKGLGAGGRLWELL 469
Query: 621 SHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQ 679
E P + E + + ++ +N F + AR + P + SIP G++ A+VG
Sbjct: 470 EREPKLPFN-EGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGP 528
Query: 680 VGCGKSSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRENI 726
G GKS++LS LL D G +++ G + V Q+ + + S+ ENI
Sbjct: 529 SGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENI 588
Query: 727 LFGCQLEEPYYRSVIQACALLPD----LEILPSGDRTEIGEK------------------ 764
+G IQ A + + + P G T +GEK
Sbjct: 589 AYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARAL 648
Query: 765 -----------------------------------TRILVTHSMSYLPQVDVIIVMSGGK 789
T +++ H +S + +++ V+ GK
Sbjct: 649 LKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGK 708
Query: 790 ISEMGSYQELLAR 802
I+E G ++ELL++
Sbjct: 709 ITEYGKHEELLSK 721
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 174 bits (440), Expect = 7e-43
Identities = 224/958 (23%), Positives = 393/958 (41%), Gaps = 156/958 (16%)
Query: 628 DSIERRPVKDGGGTNS---------ITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVV 677
++I+R+P+ D + I N TF + +R + LN + I G + A+V
Sbjct: 395 ETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALV 454
Query: 678 GQVGCGKSSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRE 724
G G GKS+ L + D EG V + G + V Q+ + + ++ E
Sbjct: 455 GPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAE 514
Query: 725 NILF-------------------------------------GCQLEEPYYRSVIQACALL 747
NI + G Q+ + V A AL+
Sbjct: 515 NIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALI 574
Query: 748 PDLEILPSGDRT------------EIGEK-----TRILVTHSMSYLPQVDVIIVMSGGKI 790
+ +IL T E+ K T I V H +S + D II G
Sbjct: 575 RNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTA 634
Query: 791 SEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSA 850
E G+++ELL R G + F ++ Q E + + A+ G DS
Sbjct: 635 VERGTHEELLERKGVY--FTLVTLQSQGNQALNEEDIKDATEDDMLARTFSRGSY-QDSL 691
Query: 851 GKQLQRQLSSSSSYSGDISR----HHNSTAELQKAEAKKEETWKLME-ADKAQTGQV-KL 904
++++ S SY H ST E E +K++ + E + A ++ K
Sbjct: 692 RASIRQRSKSQLSYLVHEPPLAVVDHKSTYE----EDRKDKDIPVQEEVEPAPVRRILKF 747
Query: 905 SV-YWDYMK--AIGLFIS--FLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVR 959
S W YM ++G ++ ++ F+ + + S I + ++ +++
Sbjct: 748 SAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFS-----------IPDKEEQRSQIN 796
Query: 960 --LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFE--RTPSGN 1015
++ A+G F A + G L ++ L ++L +++F+ R G
Sbjct: 797 GVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGA 856
Query: 1016 LVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIII----PPLGLIYF 1071
L R + + V I M + S NV A I+ + +++I P L L
Sbjct: 857 LTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGA 916
Query: 1072 FVQRFYVA-SSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQ 1130
R +SR + LE V + NE L + + ++ RFI + ++++
Sbjct: 917 TQTRMLTGFASRDKQALEMVGQIT-----NEALSNIRTVAGIGKERRFIEALETELEKPF 971
Query: 1131 KAYYPSIVANRWLAVRLECV----------------GNCIVLFAALFAVISRHSLSAGLV 1174
K + +C+ N + F+ +F VIS LSA +
Sbjct: 972 KTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATAL 1031
Query: 1175 GLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQV 1234
G + SY+ S + I A + + +++ P + TA
Sbjct: 1032 GRAFSYT-------------PSYAKAKISAA---RFFQLLDRQPPISVYNTAGEKWDNFQ 1075
Query: 1235 GRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEG 1293
G+++F + Y D VL ++V+I+ G+ + VG +G GKS+ L R + +G
Sbjct: 1076 GKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQG 1135
Query: 1294 EIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWTSLELA 1350
+++IDG + K+ + LR I I+ Q+PVLF+ S+ N+ D + E V + + A
Sbjct: 1136 KVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQA 1195
Query: 1351 HLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDD 1410
L DFV +LP+K + G LS G++Q + +ARA++R KIL+LDEAT+A+D E++
Sbjct: 1196 QLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEK 1255
Query: 1411 LIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1468
+Q + E T + IAHRL+TI + + V+ +G + E G +L+ Q+G +Y +
Sbjct: 1256 TVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKL 1313
Score = 58.9 bits (141), Expect = 3e-08
Identities = 58/232 (25%), Positives = 92/232 (39%), Gaps = 70/232 (30%)
Query: 651 FTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG--- 706
FT+ +R D LNG++ SI G +A VG GCGKS+ + L D +G V I G
Sbjct: 1085 FTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDS 1144
Query: 707 ----------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQAC--ALLPDLEI-L 753
++ V Q+ + S+ +NI +G +E VI A A L D + L
Sbjct: 1145 KKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSL 1204
Query: 754 PSGDRTEIGE-------------------------------------------------- 763
P T +G
Sbjct: 1205 PEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKA 1264
Query: 764 ---KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRT 812
+T I++ H +S + D+I VM+ G + E G+++EL+A+ GA+ + + T
Sbjct: 1265 REGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTT 1316
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 166 bits (421), Expect = 1e-40
Identities = 198/923 (21%), Positives = 369/923 (39%), Gaps = 113/923 (12%)
Query: 628 DSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSS 686
DS R K ++ + F++ +R++ L G+ + G VA+VG GCGKS+
Sbjct: 378 DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKST 437
Query: 687 LLSALLAEMDKVEGHVAIKGS-------------VAYVPQQAWIQNDSLRENILF----- 728
+ + D EG + I G + V Q+ + + ++ ENI +
Sbjct: 438 TVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNV 497
Query: 729 --------------------------------GCQLEEPYYRSVIQACALLPDLEILPSG 756
G QL + + A AL+ + +IL
Sbjct: 498 TMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD 557
Query: 757 DRTEIGE-----------------KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQEL 799
+ T + +T I++ H +S + DVI G I E GS+ EL
Sbjct: 558 EATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSEL 617
Query: 800 LARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLS 859
+ ++G + + + S Q Q +EE + + A L S K L+
Sbjct: 618 MKKEGVYFKLVNMQTSGSQIQ-SEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQM 676
Query: 860 SSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFIS 919
S + + +A K+++ +K + W Y +G +
Sbjct: 677 CQKSLDVE--------TDGLEANVPPVSFLKVLKLNKTE---------WPYF-VVGTVCA 718
Query: 920 FLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSM 979
+ L S + S D V Q+ + ++ LGI F
Sbjct: 719 IANGGLQPA--FSVIFSEIIAIFGPGDDAVK--QQKCNIFSLIFLFLGIISFFTFFLQGF 774
Query: 980 AVSIGGILASRCLHVDLLHSILRSPMSFFE--RTPSGNLVNRFSKELDTVDSMIPEVIKM 1037
G + +R L ++LR MS+F+ + +G L R + + V + +
Sbjct: 775 TFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLAL 834
Query: 1038 FMGSLFNVIGACIVILL----ATPIAAIIIPPLGLIYFFVQRFYVASS-RQLKRLESVSR 1092
++ N+ I+ + T + ++P + + + ++ R K LE+ +
Sbjct: 835 IAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGK 894
Query: 1093 SPVYSHFN-ETLLGVSVIRAFEEQ--ERFIHQSDLKVDENQKAYYPSIVANRWLAVRLEC 1149
+ N T++ ++ R FE E+ V QKA+ I + A
Sbjct: 895 IATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSV---QKAHIYGITFSISQAFMYFS 951
Query: 1150 VGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLK 1209
C A L +++ H ++ L S + L + + ++ L
Sbjct: 952 YAGCFRFGAYL--IVNGHMRFRDVI-LVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLF 1008
Query: 1210 EYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVG 1268
E + +E P + G + F Y + VL+ +++ + G+ +
Sbjct: 1009 MLFERQPLIDSYSEEGLKPDKFE--GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLA 1066
Query: 1269 IVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSL 1328
+VG +G GKS++ L R + G +++DG K+ + LR ++ I+ Q+P+LF S+
Sbjct: 1067 LVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSI 1126
Query: 1329 RMNL---DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLA 1385
N+ D S +E+ ++ + A++ F+ LP K + + G LS GQ+Q + +A
Sbjct: 1127 AENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIA 1186
Query: 1386 RALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLD 1445
RAL+R+ +IL+LDEAT+A+D E++ ++Q + E T + IAHRL+TI + ++V
Sbjct: 1187 RALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQ 1246
Query: 1446 KGEIQEYGAPSDLLQQRGLFYSM 1468
G ++E+G LL Q+G+++SM
Sbjct: 1247 NGRVKEHGTHQQLLAQKGIYFSM 1269
Score = 69.7 bits (169), Expect = 2e-11
Identities = 61/267 (22%), Positives = 104/267 (38%), Gaps = 80/267 (29%)
Query: 621 SHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQ 679
S E L+PD E +IT F + R++ P L G++ + +G +A+VG
Sbjct: 1021 SEEGLKPDKFE----------GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGS 1070
Query: 680 VGCGKSSLLSALLAEMDKVEGHVAIKGSVA-------------YVPQQAWIQNDSLRENI 726
GCGKS+++ L D + G V + G A V Q+ + + S+ ENI
Sbjct: 1071 SGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENI 1130
Query: 727 LFGCQ---LEEPYYRSVIQACALLPDLEILPSGDRTEIGEK------------------- 764
+G + + S +A + P +E LP T +G+K
Sbjct: 1131 AYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALI 1190
Query: 765 ----------------------------------TRILVTHSMSYLPQVDVIIVMSGGKI 790
T I++ H +S + D+I+V G++
Sbjct: 1191 RQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRV 1250
Query: 791 SEMGSYQELLARDGAFAEFLRTYASTE 817
E G++Q+LLA+ G + + A T+
Sbjct: 1251 KEHGTHQQLLAQKGIYFSMVSVQAGTQ 1277
>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 162 bits (409), Expect = 3e-39
Identities = 131/489 (26%), Positives = 235/489 (48%), Gaps = 28/489 (5%)
Query: 996 LLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLA 1055
L S++ SFF+ +G+L++R + + V ++ + I +F+ + V G +V + +
Sbjct: 265 LFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGV-VVFMFS 323
Query: 1056 TPIAAIIIPPLGL-IYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF-- 1112
++ +G I V Y ++L + + + + ET+ + +R+F
Sbjct: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
Query: 1113 EEQERFIH----QSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHS 1168
EE+E ++ Q K++ + A Y V L + + V +L+ VIS
Sbjct: 384 EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVS---ILYYGGHLVISGQM 440
Query: 1169 LSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPP 1228
S L+ + Y + + + + S + + A E++ E+ + + P + + +
Sbjct: 441 TSGNLIAFII-YEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQ---PTMVHDGSLA 496
Query: 1229 SSWPQVGRVEFRNYCLRYR-EDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRI 1287
+ GRV+F N YR VL++++ +++ G+ +VG +G+GKSS L
Sbjct: 497 PDHLE-GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENF 555
Query: 1288 NESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD------PFSQYSDE 1341
G +++DG I+ L I+++ Q+PVLF+ S+ N+ PF E
Sbjct: 556 YPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPF-----E 610
Query: 1342 EVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT 1401
V + + A+ F+ L D E E G LS GQ+Q V +ARAL+R +L+LDEAT
Sbjct: 611 MVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEAT 670
Query: 1402 AAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1461
+A+D E++ LIQ I + TVL IAHRL+T+ ++VLDKG + + G LL Q
Sbjct: 671 SALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ 730
Query: 1462 RGLFYSMAK 1470
GL+ + +
Sbjct: 731 GGLYAKLVQ 739
Score = 53.5 bits (127), Expect = 1e-06
Identities = 95/503 (18%), Positives = 201/503 (39%), Gaps = 104/503 (20%)
Query: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATY-INMIWSAPLQVI 452
R+ + ++R + S + G++++ ++ D DL + IN+ ++V
Sbjct: 256 RLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVT 315
Query: 453 -LALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMN---EI 508
+ +++ L+ S++ + ++M+ N + K Y+ + ++ + N E
Sbjct: 316 GVVVFMFSLSWQLSLVTFMGFPIIMMVSN----IYGKYYKRLSKEVQNALARASNTAEET 371
Query: 509 LNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVY 568
++ +K ++ +A E + L Q+ K+ +K A +A + W L+ + +Y
Sbjct: 372 ISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA--AAYMYYVWGSGLTLLVVQVSILY 429
Query: 569 VTIDENNILDAQTAFVSLALFNILRFPLN----ILPMVISSIVQASVSLKRLRIFLSHE- 623
+ ++ Q +L F I F L + V S ++Q + +++ F+ +
Sbjct: 430 Y--GGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQP 487
Query: 624 ------ELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT--LNGITFSIPEGALVA 675
L PD +E R + N TFT+ R+ P T L ++FS+ G + A
Sbjct: 488 TMVHDGSLAPDHLEGR----------VDFENVTFTY-RTRPHTQVLQNVSFSLSPGKVTA 536
Query: 676 VVGQVGCGKSSLLSALLAEMDKVEGHVAIKGS-------------VAYVPQQAWIQNDSL 722
+VG G GKSS ++ L G V + G ++ V Q+ + S+
Sbjct: 537 LVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSI 596
Query: 723 RENILF-------------------------------------GCQLEEPYYRSVIQACA 745
+NI + G QL + V A A
Sbjct: 597 TDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARA 656
Query: 746 LLPDLEILPSGDRT-----------------EIGEKTRILVTHSMSYLPQVDVIIVMSGG 788
L+ + +L + T + + T +++ H +S + +I+V+ G
Sbjct: 657 LVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKG 716
Query: 789 KISEMGSYQELLARDGAFAEFLR 811
++ + G++Q+LLA+ G +A+ ++
Sbjct: 717 RVVQQGTHQQLLAQGGLYAKLVQ 739
>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 162 bits (409), Expect = 3e-39
Identities = 131/489 (26%), Positives = 235/489 (48%), Gaps = 28/489 (5%)
Query: 996 LLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLA 1055
L S++ SFF+ +G+L++R + + V ++ + I +F+ + V G +V + +
Sbjct: 265 LFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGV-VVFMFS 323
Query: 1056 TPIAAIIIPPLGL-IYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF-- 1112
++ +G I V Y ++L + + + + ET+ + +R+F
Sbjct: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
Query: 1113 EEQERFIH----QSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHS 1168
EE+E ++ Q K++ + A Y V L + + V +L+ VIS
Sbjct: 384 EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVS---ILYYGGHLVISGQM 440
Query: 1169 LSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPP 1228
S L+ + Y + + + + S + + A E++ E+ + + P + + +
Sbjct: 441 TSGNLIAFII-YEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQ---PTMVHDGSLA 496
Query: 1229 SSWPQVGRVEFRNYCLRYR-EDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRI 1287
+ GRV+F N YR VL++++ +++ G+ +VG +G+GKSS L
Sbjct: 497 PDHLE-GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENF 555
Query: 1288 NESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD------PFSQYSDE 1341
G +++DG I+ L I+++ Q+PVLF+ S+ N+ PF E
Sbjct: 556 YPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPF-----E 610
Query: 1342 EVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT 1401
V + + A+ F+ L D E E G LS GQ+Q V +ARAL+R +L+LDEAT
Sbjct: 611 MVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEAT 670
Query: 1402 AAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1461
+A+D E++ LIQ I + TVL IAHRL+T+ ++VLDKG + + G LL Q
Sbjct: 671 SALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ 730
Query: 1462 RGLFYSMAK 1470
GL+ + +
Sbjct: 731 GGLYAKLVQ 739
Score = 53.5 bits (127), Expect = 1e-06
Identities = 95/503 (18%), Positives = 201/503 (39%), Gaps = 104/503 (20%)
Query: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATY-INMIWSAPLQVI 452
R+ + ++R + S + G++++ ++ D DL + IN+ ++V
Sbjct: 256 RLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVT 315
Query: 453 -LALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMN---EI 508
+ +++ L+ S++ + ++M+ N + K Y+ + ++ + N E
Sbjct: 316 GVVVFMFSLSWQLSLVTFMGFPIIMMVSN----IYGKYYKRLSKEVQNALARASNTAEET 371
Query: 509 LNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVY 568
++ +K ++ +A E + L Q+ K+ +K A +A + W L+ + +Y
Sbjct: 372 ISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA--AAYMYYVWGSGLTLLVVQVSILY 429
Query: 569 VTIDENNILDAQTAFVSLALFNILRFPLN----ILPMVISSIVQASVSLKRLRIFLSHE- 623
+ ++ Q +L F I F L + V S ++Q + +++ F+ +
Sbjct: 430 Y--GGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQP 487
Query: 624 ------ELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT--LNGITFSIPEGALVA 675
L PD +E R + N TFT+ R+ P T L ++FS+ G + A
Sbjct: 488 TMVHDGSLAPDHLEGR----------VDFENVTFTY-RTRPHTQVLQNVSFSLSPGKVTA 536
Query: 676 VVGQVGCGKSSLLSALLAEMDKVEGHVAIKGS-------------VAYVPQQAWIQNDSL 722
+VG G GKSS ++ L G V + G ++ V Q+ + S+
Sbjct: 537 LVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSI 596
Query: 723 RENILF-------------------------------------GCQLEEPYYRSVIQACA 745
+NI + G QL + V A A
Sbjct: 597 TDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARA 656
Query: 746 LLPDLEILPSGDRT-----------------EIGEKTRILVTHSMSYLPQVDVIIVMSGG 788
L+ + +L + T + + T +++ H +S + +I+V+ G
Sbjct: 657 LVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKG 716
Query: 789 KISEMGSYQELLARDGAFAEFLR 811
++ + G++Q+LLA+ G +A+ ++
Sbjct: 717 RVVQQGTHQQLLAQGGLYAKLVQ 739
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 159 bits (403), Expect = 1e-38
Identities = 198/930 (21%), Positives = 369/930 (39%), Gaps = 120/930 (12%)
Query: 628 DSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSS 686
DS R K ++ + F++ +R++ L G+ + G VA+VG GCGKS+
Sbjct: 378 DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKST 437
Query: 687 LLSALLAEMDKVEGHVAIKGS-------------VAYVPQQAWIQNDSLRENILF----- 728
+ + D EG + I G + V Q+ + + ++ ENI +
Sbjct: 438 TVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNV 497
Query: 729 --------------------------------GCQLEEPYYRSVIQACALLPDLEILPSG 756
G QL + + A AL+ + +IL
Sbjct: 498 TMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD 557
Query: 757 DRTEIGE-----------------KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQEL 799
+ T + +T I++ H +S + DVI G I E GS+ EL
Sbjct: 558 EATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSEL 617
Query: 800 LARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLS 859
+ ++G + + + S Q Q +EE + + A L S K L+
Sbjct: 618 MKKEGVYFKLVNMQTSGSQIQ-SEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQM 676
Query: 860 SSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFIS 919
S + + +A K+++ +K + W Y +G +
Sbjct: 677 CQKSLDVE--------TDGLEANVPPVSFLKVLKLNKTE---------WPYF-VVGTVCA 718
Query: 920 FLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSM 979
+ L S + S D V Q+ + ++ LGI F
Sbjct: 719 IANGGLQPA--FSVIFSEIIAIFGPGDDAVK--QQKCNIFSLIFLFLGIISFFTFFLQGF 774
Query: 980 AVSIGGILASRCLHVDLLHSILRSPMSFFE--RTPSGNLVNRFSKELDTVDSMIPEVIKM 1037
G + +R L ++LR MS+F+ + +G L R + + V + +
Sbjct: 775 TFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLAL 834
Query: 1038 FMGSLFNVIGACIVILL----ATPIAAIIIPPLGLIYFFVQRFYVASS-RQLKRLESVSR 1092
++ N+ I+ + T + ++P + + + ++ R K LE+ +
Sbjct: 835 IAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGK 894
Query: 1093 SPVYSHFN-ETLLGVSVIRAFEEQ--ERFIHQSDLKVDENQKAYYPSIVANRWLAVRLEC 1149
+ N T++ ++ R FE E+ V QKA+ I + A
Sbjct: 895 IATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSV---QKAHIYGITFSISQAFMYFS 951
Query: 1150 VGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLK 1209
C A L +++ H ++ L S + L + + ++ L
Sbjct: 952 YAGCFRFGAYL--IVNGHMRFRDVI-LVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLF 1008
Query: 1210 EYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVG 1268
E + +E P + G + F Y + VL+ +++ + G+ +
Sbjct: 1009 MLFERQPLIDSYSEEGLKPDKFE--GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLA 1066
Query: 1269 IVGRTGAGKSSLTLGLFRINESAEGEI-------IIDGINIAKIGLHDLRFKITIIPQDP 1321
+VG +G GKS++ L R + G + ++DG K+ + LR ++ I+ Q+P
Sbjct: 1067 LVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEP 1126
Query: 1322 VLFSGSLRMNL---DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQ 1378
+LF S+ N+ D S +E+ ++ + A++ F+ LP K + + G LS GQ
Sbjct: 1127 ILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQ 1186
Query: 1379 RQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDY 1438
+Q + +ARAL+R+ +IL+LDEAT+A+D E++ ++Q + E T + IAHRL+TI +
Sbjct: 1187 KQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNA 1246
Query: 1439 TRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1468
++V G ++E+G LL Q+G+++SM
Sbjct: 1247 DLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1276
Score = 65.5 bits (158), Expect = 4e-10
Identities = 59/274 (21%), Positives = 104/274 (37%), Gaps = 87/274 (31%)
Query: 621 SHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQ 679
S E L+PD E +IT F + R++ P L G++ + +G +A+VG
Sbjct: 1021 SEEGLKPDKFE----------GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGS 1070
Query: 680 VGCGKSSLLSALLAEMDKVEGHVAI--------------------KGSVAYVPQQAWIQN 719
GCGKS+++ L D + G V + + + V Q+ + +
Sbjct: 1071 SGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFD 1130
Query: 720 DSLRENILFGCQ---LEEPYYRSVIQACALLPDLEILPSGDRTEIGEK------------ 764
S+ ENI +G + + S +A + P +E LP T +G+K
Sbjct: 1131 CSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRI 1190
Query: 765 -----------------------------------------TRILVTHSMSYLPQVDVII 783
T I++ H +S + D+I+
Sbjct: 1191 AIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIV 1250
Query: 784 VMSGGKISEMGSYQELLARDGAFAEFLRTYASTE 817
V G++ E G++Q+LLA+ G + + A T+
Sbjct: 1251 VFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1284
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.136 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,597,887
Number of Sequences: 37866
Number of extensions: 2179254
Number of successful extensions: 6264
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 59
Number of HSP's successfully gapped in prelim test: 23
Number of HSP's that attempted gapping in prelim test: 5760
Number of HSP's gapped (non-prelim): 331
length of query: 1475
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1360
effective length of database: 13,892,928
effective search space: 18894382080
effective search space used: 18894382080
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.