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Search of human proteins with 134142340
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|134142340 ATP-binding cassette, sub-family C, member 1
isoform 2 [Homo sapiens]
(1472 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 2912 0.0
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 2831 0.0
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 2791 0.0
gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor... 2640 0.0
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 2610 0.0
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 1602 0.0
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 1234 0.0
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 1179 0.0
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 1047 0.0
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 736 0.0
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 615 e-175
gi|221316556 ATP-binding cassette, sub-family C, member 3 isofor... 589 e-168
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 573 e-163
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 542 e-153
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 507 e-143
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 505 e-142
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 495 e-139
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 495 e-139
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 480 e-135
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 480 e-135
gi|21729876 ATP-binding cassette, sub-family C, member 11 isofor... 423 e-118
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor... 322 2e-87
gi|90421313 cystic fibrosis transmembrane conductance regulator ... 276 1e-73
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 198 4e-50
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 189 2e-47
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 182 2e-45
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 177 7e-44
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 175 3e-43
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ... 162 3e-39
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member... 162 3e-39
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 2912 bits (7550), Expect = 0.0
Identities = 1472/1472 (100%), Positives = 1472/1472 (100%)
Query: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH
Sbjct: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
Query: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA
Sbjct: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
Query: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS
Sbjct: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
Query: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD
Sbjct: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
Query: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL
Sbjct: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
Query: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD
Sbjct: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
Query: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV
Sbjct: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
Query: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN
Sbjct: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
Query: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK
Sbjct: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
Query: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP
Sbjct: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
Query: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT
Sbjct: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
Query: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNLSGGQKQRVSLA 720
LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNLSGGQKQRVSLA
Sbjct: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNLSGGQKQRVSLA 720
Query: 721 RAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVII 780
RAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVII
Sbjct: 721 RAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVII 780
Query: 781 VMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENG 840
VMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENG
Sbjct: 781 VMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENG 840
Query: 841 MLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVK 900
MLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVK
Sbjct: 841 MLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVK 900
Query: 901 LSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVY 960
LSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVY
Sbjct: 901 LSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVY 960
Query: 961 GALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKE 1020
GALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKE
Sbjct: 961 GALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKE 1020
Query: 1021 LDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQ 1080
LDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQ
Sbjct: 1021 LDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQ 1080
Query: 1081 LKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWL 1140
LKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWL
Sbjct: 1081 LKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWL 1140
Query: 1141 AVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV 1200
AVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV
Sbjct: 1141 AVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV 1200
Query: 1201 AVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTING 1260
AVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTING
Sbjct: 1201 AVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTING 1260
Query: 1261 GEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVL 1320
GEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVL
Sbjct: 1261 GEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVL 1320
Query: 1321 FSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVC 1380
FSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVC
Sbjct: 1321 FSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVC 1380
Query: 1381 LARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIV 1440
LARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIV
Sbjct: 1381 LARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIV 1440
Query: 1441 LDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1472
LDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV
Sbjct: 1441 LDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1472
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 2831 bits (7339), Expect = 0.0
Identities = 1452/1533 (94%), Positives = 1458/1533 (95%), Gaps = 63/1533 (4%)
Query: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH
Sbjct: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
Query: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA
Sbjct: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
Query: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS
Sbjct: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
Query: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD
Sbjct: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
Query: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL
Sbjct: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
Query: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD
Sbjct: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
Query: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV
Sbjct: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
Query: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN
Sbjct: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
Query: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK
Sbjct: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
Query: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP
Sbjct: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
Query: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT
Sbjct: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
Query: 661 LNGITFSIPEGAL----------------------------VAVVGQV------------ 680
LNGITFSIPEGAL VA+ G V
Sbjct: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND 720
Query: 681 --------GCGKS-----SLLSA--------LLAEMDKVEGHVAIKGVNLSGGQKQRVSL 719
GC S++ A +L D+ E + KGVNLSGGQKQRVSL
Sbjct: 721 SLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTE--IGEKGVNLSGGQKQRVSL 778
Query: 720 ARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVI 779
ARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVI
Sbjct: 779 ARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVI 838
Query: 780 IVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMEN 839
IVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMEN
Sbjct: 839 IVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMEN 898
Query: 840 GMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQV 899
GMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQV
Sbjct: 899 GMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQV 958
Query: 900 KLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSV 959
KLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSV
Sbjct: 959 KLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSV 1018
Query: 960 YGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSK 1019
YGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSK
Sbjct: 1019 YGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSK 1078
Query: 1020 ELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSR 1079
ELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSR
Sbjct: 1079 ELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSR 1138
Query: 1080 QLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRW 1139
QLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRW
Sbjct: 1139 QLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRW 1198
Query: 1140 LAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNI 1199
LAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNI
Sbjct: 1199 LAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNI 1258
Query: 1200 VAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTIN 1259
VAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTIN
Sbjct: 1259 VAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTIN 1318
Query: 1260 GGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPV 1319
GGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPV
Sbjct: 1319 GGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPV 1378
Query: 1320 LFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLV 1379
LFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLV
Sbjct: 1379 LFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLV 1438
Query: 1380 CLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVI 1439
CLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVI
Sbjct: 1439 CLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVI 1498
Query: 1440 VLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1472
VLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV
Sbjct: 1499 VLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1531
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 2791 bits (7234), Expect = 0.0
Identities = 1427/1478 (96%), Positives = 1436/1478 (97%), Gaps = 9/1478 (0%)
Query: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH
Sbjct: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
Query: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA
Sbjct: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
Query: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS
Sbjct: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
Query: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD
Sbjct: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
Query: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL
Sbjct: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
Query: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD
Sbjct: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
Query: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV
Sbjct: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
Query: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN
Sbjct: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
Query: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK
Sbjct: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
Query: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP
Sbjct: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
Query: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT
Sbjct: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
Query: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNLSGGQK---QRV 717
LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG Q+ Q
Sbjct: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND 720
Query: 718 SLARAVYSNADIYLFDDPL--SAVDAHVGKHIFENV-IGPKGMLKNKTRILVTHSMSYLP 774
SL + + ++P S + A E + G + + KTRILVTHSMSYLP
Sbjct: 721 SLRENILFGCQL---EEPYYRSVIQACALLPDLEILPSGDRTEIGEKTRILVTHSMSYLP 777
Query: 775 QVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEA 834
QVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEA
Sbjct: 778 QVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEA 837
Query: 835 KQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKA 894
KQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKA
Sbjct: 838 KQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKA 897
Query: 895 QTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTK 954
QTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTK
Sbjct: 898 QTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTK 957
Query: 955 VRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLV 1014
VRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLV
Sbjct: 958 VRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLV 1017
Query: 1015 NRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFY 1074
NRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFY
Sbjct: 1018 NRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFY 1077
Query: 1075 VASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSI 1134
VASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSI
Sbjct: 1078 VASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSI 1137
Query: 1135 VANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSE 1194
VANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSE
Sbjct: 1138 VANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSE 1197
Query: 1195 METNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHI 1254
METNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHI
Sbjct: 1198 METNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHI 1257
Query: 1255 NVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITII 1314
NVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITII
Sbjct: 1258 NVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITII 1317
Query: 1315 PQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVG 1374
PQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVG
Sbjct: 1318 PQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVG 1377
Query: 1375 QRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMD 1434
QRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMD
Sbjct: 1378 QRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMD 1437
Query: 1435 YTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1472
YTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV
Sbjct: 1438 YTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1475
>gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5
[Homo sapiens]
Length = 1466
Score = 2640 bits (6844), Expect = 0.0
Identities = 1352/1434 (94%), Positives = 1358/1434 (94%), Gaps = 63/1434 (4%)
Query: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH
Sbjct: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
Query: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA
Sbjct: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
Query: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS
Sbjct: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
Query: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD
Sbjct: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
Query: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL
Sbjct: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
Query: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD
Sbjct: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
Query: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV
Sbjct: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
Query: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN
Sbjct: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
Query: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK
Sbjct: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
Query: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP
Sbjct: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
Query: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT
Sbjct: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
Query: 661 LNGITFSIPEGAL----------------------------VAVVGQV------------ 680
LNGITFSIPEGAL VA+ G V
Sbjct: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND 720
Query: 681 --------GCGKS-----SLLSA--------LLAEMDKVEGHVAIKGVNLSGGQKQRVSL 719
GC S++ A +L D+ E + KGVNLSGGQKQRVSL
Sbjct: 721 SLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTE--IGEKGVNLSGGQKQRVSL 778
Query: 720 ARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVI 779
ARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVI
Sbjct: 779 ARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVI 838
Query: 780 IVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMEN 839
IVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMEN
Sbjct: 839 IVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMEN 898
Query: 840 GMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQV 899
GMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQV
Sbjct: 899 GMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQV 958
Query: 900 KLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSV 959
KLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSV
Sbjct: 959 KLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSV 1018
Query: 960 YGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSK 1019
YGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSK
Sbjct: 1019 YGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSK 1078
Query: 1020 ELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSR 1079
ELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSR
Sbjct: 1079 ELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSR 1138
Query: 1080 QLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRW 1139
QLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRW
Sbjct: 1139 QLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRW 1198
Query: 1140 LAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNI 1199
LAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNI
Sbjct: 1199 LAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNI 1258
Query: 1200 VAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTIN 1259
VAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTIN
Sbjct: 1259 VAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTIN 1318
Query: 1260 GGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPV 1319
GGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPV
Sbjct: 1319 GGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPV 1378
Query: 1320 LFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSV 1373
LFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENL V
Sbjct: 1379 LFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLRV 1432
Score = 95.9 bits (237), Expect = 3e-19
Identities = 96/375 (25%), Positives = 159/375 (42%), Gaps = 27/375 (7%)
Query: 1097 NETLLGVSVIR------AFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNC 1150
NE L G+ V++ AF+++ I Q +LKV + + AY ++ W+ V C
Sbjct: 506 NEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK-KSAYLSAVGTFTWVCTPF-LVALC 563
Query: 1151 IVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSE 1210
FA + + L A +S++ + LN L + S + V+++RL+ +
Sbjct: 564 T--FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLS 621
Query: 1211 TEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRT 1270
E+ P I E P + RN + L I +I G V +VG+
Sbjct: 622 HEELEPDSI-ERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQV 680
Query: 1271 GAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD 1330
G GKSSL L + EG + I G + +PQ + + SLR N+
Sbjct: 681 GCGKSSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRENIL 727
Query: 1331 PFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTK 1390
Q + + ++ L + LP E E G NLS GQ+Q V LARA+
Sbjct: 728 FGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNAD 787
Query: 1391 ILVLDEATAAVDLETDDLIQSTI---RTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQ 1447
I + D+ +AVD I + + ++ T + + H ++ + +IV+ G+I
Sbjct: 788 IYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKIS 847
Query: 1448 EYGAPSDLLQQRGLF 1462
E G+ +LL + G F
Sbjct: 848 EMGSYQELLARDGAF 862
Score = 73.6 bits (179), Expect = 1e-12
Identities = 36/36 (100%), Positives = 36/36 (100%)
Query: 1437 RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1472
RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV
Sbjct: 1431 RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1466
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 2610 bits (6764), Expect = 0.0
Identities = 1343/1472 (91%), Positives = 1360/1472 (92%), Gaps = 56/1472 (3%)
Query: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH
Sbjct: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
Query: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA
Sbjct: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
Query: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS
Sbjct: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
Query: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD
Sbjct: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
Query: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL
Sbjct: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
Query: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD
Sbjct: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
Query: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV
Sbjct: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
Query: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN
Sbjct: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
Query: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK
Sbjct: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
Query: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP
Sbjct: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
Query: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT
Sbjct: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
Query: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNLSGGQKQRVSLA 720
LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIK
Sbjct: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIK--------------T 706
Query: 721 RAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVII 780
R + +++ Y L VD + ++ +S + ++
Sbjct: 707 RILVTHSMSY-----LPQVDVII--------------------VMSGGKISEMGSYQELL 741
Query: 781 VMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENG 840
G + +Y A + + +E ENG+ GK
Sbjct: 742 ARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK-------- 793
Query: 841 MLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVK 900
QLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVK
Sbjct: 794 ---------QLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVK 844
Query: 901 LSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVY 960
LSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVY
Sbjct: 845 LSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVY 904
Query: 961 GALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKE 1020
GALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKE
Sbjct: 905 GALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKE 964
Query: 1021 LDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQ 1080
LDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQ
Sbjct: 965 LDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQ 1024
Query: 1081 LKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWL 1140
LKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWL
Sbjct: 1025 LKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWL 1084
Query: 1141 AVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV 1200
AVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV
Sbjct: 1085 AVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV 1144
Query: 1201 AVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTING 1260
AVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTING
Sbjct: 1145 AVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTING 1204
Query: 1261 GEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVL 1320
GEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVL
Sbjct: 1205 GEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVL 1264
Query: 1321 FSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVC 1380
FSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVC
Sbjct: 1265 FSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVC 1324
Query: 1381 LARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIV 1440
LARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIV
Sbjct: 1325 LARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIV 1384
Query: 1441 LDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1472
LDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV
Sbjct: 1385 LDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1416
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 1602 bits (4149), Expect = 0.0
Identities = 828/1538 (53%), Positives = 1081/1538 (70%), Gaps = 92/1538 (5%)
Query: 8 SADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQM 67
S + WD N++ +T NPD T CFQN++L WVPC YLW P Y LYL H RGYI +
Sbjct: 7 SGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIIL 66
Query: 68 TPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLE 127
+ L+K K LG LLW V WADLFYSF G APVF V+P ++G+TMLLAT LIQ E
Sbjct: 67 SHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYE 126
Query: 128 RRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLV 187
R +GVQSSG+++ FW + +VCA+ RSKI+ A E D FR TFY++F+L+L L+
Sbjct: 127 RLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALI 186
Query: 188 LSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKE 247
L+CF ++ P FS DPNP PE+SA FLSR+ FWW T + + GYR PLE DLWSL +E
Sbjct: 187 LACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEE 246
Query: 248 DTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQK 307
D S+ VV L++ W+K+ +T + K A P ++ A+ E E L+ P+
Sbjct: 247 DRSQMVVQQLLEAWRKQEKQTARH--------KASAAPGKN----ASGEDEVLLGARPRP 294
Query: 308 EWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYT 367
PS K L TFG FL+S FK I DL+ F PQ+L +LI+F+++ AP W G+
Sbjct: 295 R-KPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVA 353
Query: 368 VLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLM 427
L+F+ + +Q+L+L Y+H FV+G++ +T ++G +YRKALVITNS +++STVGEIVNLM
Sbjct: 354 GLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLM 413
Query: 428 SVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKT 487
SVDAQRFMDLA ++N++WSAPLQ+ILA+Y LW NLGPSVLAGVA MVL++P+N +A+K
Sbjct: 414 SVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKM 473
Query: 488 KTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSA 547
+ +QV MK KD+RIKLM+EILNGIKVLKLYAWE +F +V IRQ EL++L+ +AYL
Sbjct: 474 RAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHT 533
Query: 548 VGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIV 607
TFTW+C+PFLV L T VYV +D NN+LDA+ AFVS++LFNILR PLN+LP +IS++
Sbjct: 534 TTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLT 593
Query: 608 QASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFS 667
QASVSLKR++ FLS EEL+P S+ER+ + G +IT+ + TFTWA+ PPTL+ +
Sbjct: 594 QASVSLKRIQQFLSQEELDPQSVERKTISPG---YAITIHSGTFTWAQDLPPTLHSLDIQ 650
Query: 668 IPEGALVAVVGQVGCGK----SSLLS---------------------------------- 689
+P+GALVAVVG VGCGK S+LL
Sbjct: 651 VPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVL 710
Query: 690 -----------------ALLAEMDKVEG----HVAIKGVNLSGGQKQRVSLARAVYSNAD 728
ALLA+++ + G + KG+NLSGGQ+QRVSLARAVYS+AD
Sbjct: 711 FGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDAD 770
Query: 729 IYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKIS 788
I+L DDPLSAVD+HV KHIF++VIGP+G+L KTR+LVTH +S+LPQ D IIV++ G++S
Sbjct: 771 IFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVS 830
Query: 789 EMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGML------ 842
EMG Y LL R+G+FA FL YA E + E++ KEA +E+ +
Sbjct: 831 EMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLT 890
Query: 843 ----VTDSAGKQLQRQLSSSSS----YSGDISRHHNSTAE-LQKAEAKKEETWKLMEADK 893
VT KQ RQLS+ SS + R H +E +Q EAK + L + +K
Sbjct: 891 DNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGA--LTQEEK 948
Query: 894 AQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHT 953
A G V+LSV+WDY KA+GL + L++ +A+ +N WLS WT+D + + Q +T
Sbjct: 949 AAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNT 1008
Query: 954 KVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNL 1013
+RL VY ALGI QG V +MA++ GGI A+R LH LLH+ +RSP SFF+ TPSG +
Sbjct: 1009 SLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRI 1068
Query: 1014 VNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRF 1073
+N FSK++ VD ++ VI M + S FN I +VI+ +TP+ ++I PL ++Y VQRF
Sbjct: 1069 LNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRF 1128
Query: 1074 YVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPS 1133
Y A+SRQLKRLESVSRSP+YSHF+ET+ G SVIRA+ F SD KVD NQ++ YP
Sbjct: 1129 YAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPY 1188
Query: 1134 IVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSS 1193
I++NRWL++ +E VGNC+VLFAALFAVI R SL+ GLVGLSVSYSLQVT LNW++RM S
Sbjct: 1189 IISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMS 1248
Query: 1194 EMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRH 1253
++E+NIVAVER+KEYS+TE EAPW ++ + PP WP G VEFRNY +RYR LD VLR
Sbjct: 1249 DLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRD 1308
Query: 1254 INVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITI 1313
+++ ++GGEKVGIVGRTGAGKSS+TL LFRI E+A+GEI IDG+N+A IGLHDLR ++TI
Sbjct: 1309 LSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTI 1368
Query: 1314 IPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSV 1373
IPQDP+LFSG+LRMNLDPF YS+E++W +LEL+HL FVS+ P LD +C+EGGENLSV
Sbjct: 1369 IPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSV 1428
Query: 1374 GQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIM 1433
GQRQLVCLARALLRK++ILVLDEATAA+DLETD+LIQ+TIRTQF+ CTVLTIAHRLNTIM
Sbjct: 1429 GQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIM 1488
Query: 1434 DYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGL 1471
DYTRV+VLDKG + E+ +P++L+ RG+FY MA+DAGL
Sbjct: 1489 DYTRVLVLDKGVVAEFDSPANLIAARGIFYGMARDAGL 1526
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 1234 bits (3193), Expect = 0.0
Identities = 693/1545 (44%), Positives = 973/1545 (62%), Gaps = 113/1545 (7%)
Query: 22 WNTS-----NPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTA 76
WN+S D CF+ TVLVW+P +LW P+ L++ + T L K
Sbjct: 11 WNSSFLDSPEADLPLCFEQTVLVWIPLGFLWLLAPWQLLHVYKSRTKRSSTTKLYLAKQV 70
Query: 77 -LGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSS 135
+GFLL I+ +L E S + V +P+L T LL LIQ R+ VQ +
Sbjct: 71 FVGFLL-ILAAIELALVLTEDSGQATVPAVRYTNPSLYLGTWLLV-LLIQYSRQWCVQKN 128
Query: 136 GIMLT-FWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDR 194
L+ FW+++++C ++ I T L+ D +L F++ + ++ L+ S FS+
Sbjct: 129 SWFLSLFWILSILCGTFQFQTLIRTLLQGDNS-NLAYSCLFFISYGFQILILIFSAFSEN 187
Query: 195 SPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVV 254
+ + + P S ASFLS IT+ W +I++GY++PL D+W +++E ++ +V
Sbjct: 188 N--------ESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLV 239
Query: 255 PVLVKNWKKECAKTRK--QPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPS 312
+ K+E K R+ Q + S ++ + ++ +AL+++ +K+ S
Sbjct: 240 SKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKS 299
Query: 313 ----------LFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQ 362
L K L+KTF L SF K ++D+ F PQ+LKLLI F +D W
Sbjct: 300 GTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWI 359
Query: 363 GYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGE 422
GY +LLF A +Q+ L YF +CF G++++TA++ +VY+KAL ++N ARK TVGE
Sbjct: 360 GYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGE 419
Query: 423 IVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAV 482
VNLMSVDAQ+ MD+ +++M+WS+ LQ++L+++ LW LGPSVLAGV VMVL++P+NA+
Sbjct: 420 TVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAI 479
Query: 483 MAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKS 542
++ K+KT QV +MK+KD R+K+MNEIL+GIK+LK +AWE +F+D+V +R++ELK L
Sbjct: 480 LSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAF 539
Query: 543 AYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMV 602
+ L V F + TP LV++ TF+VYV +D NNILDAQ AF S+ LFNILRFPL++LPM+
Sbjct: 540 SQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMM 599
Query: 603 ISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLN 662
ISS++QASVS +RL +L ++L+ +I D ++ A+FTW T+
Sbjct: 600 ISSMLQASVSTERLEKYLGGDDLDTSAIRH----DCNFDKAMQFSEASFTWEHDSEATVR 655
Query: 663 GITFSIPEGALVAVVG---------------------------------------QVGCG 683
+ I G LVAV+G Q G
Sbjct: 656 DVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTI 715
Query: 684 KSSLL----------------SALLAEMDKVEG----HVAIKGVNLSGGQKQRVSLARAV 723
K ++L ALL +++ + G + KG+NLSGGQKQR+SLARA
Sbjct: 716 KDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARAT 775
Query: 724 YSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMS 783
Y N DIYL DDPLSAVDAHVGKHIF V+GP G+LK KTR+LVTHSM +LPQVD I+V+
Sbjct: 776 YQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLG 835
Query: 784 GGKISEMGSYQELLARDGAFAEFLRTYAS-TEQEQDA-------EENGVTGVSGPGKEAK 835
G I E GSY LLA+ G FA+ L+T+ T E++A EE+ G+ +E
Sbjct: 836 NGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIP 895
Query: 836 QMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEET-----WKLME 890
E+ +T +R LS SS +G + ++ + + + KE+ KL++
Sbjct: 896 --EDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIK 953
Query: 891 ADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDP-IVNGT 949
+ +TG+VK S+Y +Y++AIGLF F I F+ N V+ + SN WLS WT D I N T
Sbjct: 954 KEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNST 1013
Query: 950 Q---EHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFE 1006
+R+ VYGALG++QGI VF + G + AS LH LL++ILR+PM FF+
Sbjct: 1014 DYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFD 1073
Query: 1007 RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLI 1066
TP+G +VNRF+ ++ TVD +P+ ++ ++ +I ++I +ATP+ II+ PLG+I
Sbjct: 1074 TTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGII 1133
Query: 1067 YFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDEN 1126
Y VQ FYV++SRQL+RL+SV+RSP+YSHF+ET+ G+ VIRAFE Q+RF+ +++++D N
Sbjct: 1134 YVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTN 1193
Query: 1127 QKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLN 1186
QK + I +NRWLA+RLE VGN V F+AL VI R +LS VG +S +L +T LN
Sbjct: 1194 QKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLN 1253
Query: 1187 WLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYRED 1246
WLVRM+SE+ETNIVAVER+ EY++ E EAPW + + PP WP G+++F NY +RYR +
Sbjct: 1254 WLVRMTSEIETNIVAVERITEYTKVENEAPW-VTDKRPPPDWPSKGKIQFNNYQVRYRPE 1312
Query: 1247 LDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHD 1306
LD VLR I I EK+G+VGRTGAGKSSLT LFRI E+A G+IIIDG++IA IGLHD
Sbjct: 1313 LDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHD 1372
Query: 1307 LRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAE 1366
LR K+TIIPQDP+LFSGSLRMNLDPF+ YSDEE+W +LELAHLK FV++L L HE E
Sbjct: 1373 LREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTE 1432
Query: 1367 GGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIA 1426
G NLS+GQRQL+CL RALLRK+KILVLDEATAAVDLETD+LIQ+TI+ +F CTV+TIA
Sbjct: 1433 AGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIA 1492
Query: 1427 HRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGL 1471
HRL+TIMD +V+VLD G+I E G+P +LLQ G FY MAK+AG+
Sbjct: 1493 HRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGI 1537
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 1179 bits (3049), Expect = 0.0
Identities = 651/1521 (42%), Positives = 927/1521 (60%), Gaps = 101/1521 (6%)
Query: 22 WNTSNPD------FTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKT 75
WN + P+ + CF T VWVP YLW P Y L++ H RGY++M+PL K K
Sbjct: 14 WNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGRGYLRMSPLFKAKM 73
Query: 76 ALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSS 135
LGF L ++C + + + W+ +G AP FL+ PT+ TM A FLI ER+KGVQSS
Sbjct: 74 VLGFALIVLCTSSVAVALWKIQQGTPEAPEFLIHPTVWLTTMSFAVFLIHTERKKGVQSS 133
Query: 136 GIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRS 195
G++ +WL+ C + + A Q D R ++ Y+ SL++ Q VLSC +D+
Sbjct: 134 GVLFGYWLL---CFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQFVLSCLADQP 190
Query: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
P F E NPCPE+ A+F S+ TFWW++GL+ RGYR+PL DLWSL +E++SE++V
Sbjct: 191 PFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVS 250
Query: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
L K W + + R+ + + K + K E E + + +W P L K
Sbjct: 251 RLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAP-------ETEPFL-RQEGSQWRP-LLK 301
Query: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTAC 375
+++ F FL+ I D+ F+ P++L L ++F+ D K P W+GY VL+F++AC
Sbjct: 302 AIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSAC 361
Query: 376 LQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFM 435
LQTL Q + V MR+++A+ G VYRK L +++ +RK+S VG++VNL+SVD QR
Sbjct: 362 LQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLT 421
Query: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
+ Y+N +W + +++ LW LGPS L +AV + ++P+N ++ K +Q M
Sbjct: 422 ESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQM 481
Query: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
+ KD+R +L + IL K +K + WE AF D+VL IR +EL L+ S L +V ++
Sbjct: 482 RQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQV 541
Query: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
+ FLVAL FAV+ + EN ++A+ AFV+L + NIL LP I S+VQA VS R
Sbjct: 542 STFLVALVVFAVHTLVAEN-AMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDR 600
Query: 616 LRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVA 675
L FL EE++P ++ G + IT+ +ATF W++ PP L+ I ++P+G L+A
Sbjct: 601 LVTFLCLEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLA 660
Query: 676 VVGQVGCGK----SSLLS------------------------------------------ 689
VVG VG GK S+LL
Sbjct: 661 VVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPP 720
Query: 690 ---------ALLAEMDKV-EG-HVAI--KGVNLSGGQKQRVSLARAVYSNADIYLFDDPL 736
AL ++D EG H +I +G+NLSGGQKQR+SLARAVY A +YL DDPL
Sbjct: 721 WLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPL 780
Query: 737 SAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQEL 796
+A+DAHVG+H+F VIGP G+L+ TRILVTH++ LPQ D IIV++ G I+EMGSYQEL
Sbjct: 781 AALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQEL 840
Query: 797 LARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK--QLQRQ 854
L R GA L +Q + + G G + PG K SAG+ +L+R+
Sbjct: 841 LQRKGALVCLL------DQARQPGDRG-EGETEPGTSTKDPRG-----TSAGRRPELRRE 888
Query: 855 LSSSSSYSGDISRHHNSTAELQKA---EAKKEETWKLMEADKAQTGQVKLSVYWDYMKAI 911
S S + +T+E Q + W + D Q G+VK +V+ Y++A+
Sbjct: 889 RSIKS-----VPEKDRTTSEAQTEVPLDDPDRAGWPAGK-DSIQYGRVKATVHLAYLRAV 942
Query: 912 GLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAV 971
G + ++FLF+C V++ YWLSLW DDP V G Q +R ++G LG Q I +
Sbjct: 943 GTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGL 1002
Query: 972 FGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEV 1031
F AV +GG ASR L LL ++RSP+SFFERTP G+L+NRFSKE DTVD IP+
Sbjct: 1003 FASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDK 1062
Query: 1032 IKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSP 1091
++ + F ++ +V+ +ATP+A + I PL L+Y Q YV SS QL+RLES S S
Sbjct: 1063 LRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSS 1122
Query: 1092 VYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCI 1151
V SH ET G +V+RAF Q F+ Q++ +VDE+Q+ +P +VA+RWLA +E +GN +
Sbjct: 1123 VCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGL 1182
Query: 1152 VLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET 1211
V AA AV+S+ LSAGLVG SVS +LQVT L W+VR +++E +IV+VER+++Y+ T
Sbjct: 1183 VFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWT 1242
Query: 1212 EKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTG 1271
KEAPW++ A WPQ G++EFR++ LRYR +L ++ ++ I+ GEKVGIVGRTG
Sbjct: 1243 PKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTG 1302
Query: 1272 AGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDP 1331
AGKSSL GL R+ E+AEG I IDG+ IA +GLH LR +I+IIPQDP+LF GSLRMNLD
Sbjct: 1303 AGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDL 1362
Query: 1332 FSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKI 1391
++SDE +W +LE LK V++LP +L ++CA+ GE+LSVGQ+QL+CLARALLRKT+I
Sbjct: 1363 LQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQI 1422
Query: 1392 LVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGA 1451
L+LDEATAAVD T+ +Q+ + + F CTVL IAHRL ++MD RV+V+DKG++ E G+
Sbjct: 1423 LILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGS 1482
Query: 1452 PSDLLQQRGLFYSMAKDAGLV 1472
P+ LL Q+GLFY +A+++GLV
Sbjct: 1483 PAQLLAQKGLFYRLAQESGLV 1503
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 1047 bits (2707), Expect = 0.0
Identities = 579/1340 (43%), Positives = 830/1340 (61%), Gaps = 92/1340 (6%)
Query: 197 LFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPV 256
+F+ + NPCPE+ A+F S+ TFWW++GL+ RGYR+PL DLWSL +E++SE++V
Sbjct: 1 MFTFSTKYTNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSR 60
Query: 257 LVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKV 316
L K W + + R+ + + K + K E E + + +W P L K
Sbjct: 61 LEKEWMRNRSAARRHNKAIAFKRKGGSGMKAP-------ETEPFL-RQEGSQWRP-LLKA 111
Query: 317 LYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACL 376
+++ F FL+ I D+ F+ P++L L ++F+ D K P W+GY VL+F++ACL
Sbjct: 112 IWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACL 171
Query: 377 QTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMD 436
QTL Q + V MR+++A+ G VYRK L +++ +RK+S VG++VNL+SVD QR +
Sbjct: 172 QTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTE 231
Query: 437 LATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMK 496
Y+N +W + +++ LW LGPS L +AV + ++P+N ++ K +Q M+
Sbjct: 232 SVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMR 291
Query: 497 SKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCT 556
KD+R +L + IL K +K + WE AF D+VL IR +EL L+ S L +V ++ +
Sbjct: 292 QKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVS 351
Query: 557 PFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRL 616
FLVAL FAV+ + EN ++A+ AFV+L + NIL LP I S+VQA VS RL
Sbjct: 352 TFLVALVVFAVHTLVAEN-AMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRL 410
Query: 617 RIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAV 676
FL EE++P +++ G + IT+++ATF W++ PP L+ I ++P+G L+AV
Sbjct: 411 VTFLCLEEVDPGAVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAV 470
Query: 677 VGQVGCGK----SSLLS------------------------------------------- 689
VG VG GK S+LL
Sbjct: 471 VGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPW 530
Query: 690 --------ALLAEMDKV-EG-HVAI--KGVNLSGGQKQRVSLARAVYSNADIYLFDDPLS 737
AL ++D EG H +I +G+NLSGGQKQR+SLARAVY A +YL DDPL+
Sbjct: 531 LERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLA 590
Query: 738 AVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELL 797
A+DAHVG+H+F VIGP G+L+ TRILVTH++ LPQ D IIV++ G I+EMGSYQELL
Sbjct: 591 ALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELL 650
Query: 798 ARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK--QLQRQL 855
R GA L +Q + + G G + PG K SAG+ +L+R+
Sbjct: 651 QRKGALVCLL------DQARQPGDRG-EGETEPGTSTKDPRG-----TSAGRRPELRRER 698
Query: 856 SSSSSYSGDISRHHNSTAELQKA---EAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIG 912
S S + +T+E Q + W + D Q G+VK +V+ Y++A+G
Sbjct: 699 SIKS-----VPEKDRTTSEAQTEVPLDDPDRAGWPAGK-DSIQYGRVKATVHLAYLRAVG 752
Query: 913 LFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVF 972
+ ++FLF+C V++ YWLSLW DDP V G Q +R ++G LG Q I +F
Sbjct: 753 TPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLF 812
Query: 973 GYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVI 1032
AV +GG ASR L LL ++RSP+SFFERTP G+L+NRFSKE DTVD IP+ +
Sbjct: 813 ASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKL 872
Query: 1033 KMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPV 1092
+ + F ++ +V+ +ATP+A + I PL L+Y Q YV SS QL+RLES S S V
Sbjct: 873 RSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSV 932
Query: 1093 YSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIV 1152
SH ET G +V+RAF Q F+ Q++ +VDE+Q+ +P +VA+RWLA +E +GN +V
Sbjct: 933 CSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLV 992
Query: 1153 LFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETE 1212
AA AV+S+ LSAGLVG SVS +LQVT L W+VR +++E +IV+VER+++Y+ T
Sbjct: 993 FAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTP 1052
Query: 1213 KEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGA 1272
KEAPW++ A WPQ G++EF+++ LRYR +L ++ ++ I+ GEKVGIVGRTGA
Sbjct: 1053 KEAPWRLPTCAAQPPWPQGGQIEFQDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGA 1112
Query: 1273 GKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPF 1332
GKSSL GL R+ E+AEG I IDG+ IA +GLH LR +I+IIPQDP+LF GSLRMNLD
Sbjct: 1113 GKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLL 1172
Query: 1333 SQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKIL 1392
++SDE +W +LE LK V++LP +L ++CA+ GE+LSVGQ+QL+CLARALLRKT+IL
Sbjct: 1173 QEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQIL 1232
Query: 1393 VLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAP 1452
+LDEATAAVD T+ +Q+ + + F CTVL IAHRL ++MD RV+V+DKG++ E G+P
Sbjct: 1233 ILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSP 1292
Query: 1453 SDLLQQRGLFYSMAKDAGLV 1472
+ LL Q+GLFY +A+++GLV
Sbjct: 1293 AQLLAQKGLFYRLAQESGLV 1312
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 736 bits (1901), Expect = 0.0
Identities = 467/1356 (34%), Positives = 730/1356 (53%), Gaps = 162/1356 (11%)
Query: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
P++ E P P A+ SR+ FWW+ L G+++ LE D++S+ ED S+ +
Sbjct: 3 PVYQEV----KPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGE 58
Query: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
L W KE + K PSL +
Sbjct: 59 ELQGFWDKEVLRAENDAQK------------------------------------PSLTR 82
Query: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVN-----DTKAPDWQGYFYTVLL 370
+ K + +L+ F I + P L +I + D+ A + + TVL
Sbjct: 83 AIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLT 142
Query: 371 FVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVD 430
F T L ++ H YF+ +GMR++ A+ +YRKAL ++N A +T G+IVNL+S D
Sbjct: 143 FCTLIL-AILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSND 201
Query: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
+F + +++ +W+ PLQ I LLW+ +G S LAG+AV+++++P+ + +
Sbjct: 202 VNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSL 261
Query: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
+ D RI+ MNE++ GI+++K+YAWE +F + + +R++E+ + +S+ L +
Sbjct: 262 RSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNL 321
Query: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNIL-PMVISSIVQA 609
++ ++ TF YV + +++ A FV++ L+ +R + + P I + +A
Sbjct: 322 ASFFSASKIIVFVTFTTYVLL--GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA 379
Query: 610 SVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWAR-SDPPTLNGITFSI 668
VS++R++ FL +E+ +R G + V++ T W + S+ PTL G++F++
Sbjct: 380 IVSIRRIQTFLLLDEIS----QRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTV 435
Query: 669 PEGALVA---------------VVGQV------------------------GCGKSSLLS 689
G L+A V+G++ G +S++L
Sbjct: 436 RPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILF 495
Query: 690 ALLAEMDKVE-----------------GHVAI---KGVNLSGGQKQRVSLARAVYSNADI 729
E ++ E G + + +G LSGGQK RV+LARAVY +ADI
Sbjct: 496 GKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADI 555
Query: 730 YLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISE 789
YL DDPLSAVDA V +H+FE I +L K ILVTH + YL I+++ GK+ +
Sbjct: 556 YLLDDPLSAVDAEVSRHLFELCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQ 613
Query: 790 MGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK 849
G+Y E L F L+ +D EE+ V G + N
Sbjct: 614 KGTYTEFLKSGIDFGSLLK--------KDNEESEQPPVPG----TPTLRN---------- 651
Query: 850 QLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMK 909
R S SS +S SR L+ + + L E ++++ G+V Y +Y +
Sbjct: 652 ---RTFSESSVWSQQSSRPSLKDGALESQDTENVPV-TLSEENRSE-GKVGFQAYKNYFR 706
Query: 910 AIGLFISFLSIFLFMCNHVSALA---SNYWLSLWTD-----DPIVNGTQEHTKVRLSVYG 961
A +I F IFL + N + +A ++WLS W + + VNG T+ +L +
Sbjct: 707 AGAHWIVF--IFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTE-KLDLNW 763
Query: 962 ALGISQGIAV----FGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVN 1015
LGI G+ V FG + ++ + +L +S+ LH + SIL++P+ FF+R P G ++N
Sbjct: 764 YLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILN 823
Query: 1016 RFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYV 1075
RFSK++ +D ++P F+ +L V+G V + P AI + PLG+I+ F++R+++
Sbjct: 824 RFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFL 883
Query: 1076 ASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIV 1135
+SR +KRLES +RSPV+SH + +L G+ IRA++ +ER D D + +A++ +
Sbjct: 884 ETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLT 943
Query: 1136 ANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEM 1195
+RW AVRL+ + V+ A ++I +L AG VGL++SY+L + W VR S+E+
Sbjct: 944 TSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEV 1003
Query: 1196 ETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHIN 1255
E +++VER+ EY++ EKEAPW+ Q+ PP+ WP G + F N Y VL+H+
Sbjct: 1004 ENMMISVERVIEYTDLEKEAPWEYQKRPPPA-WPHEGVIIFDNVNFMYSPGGPLVLKHLT 1062
Query: 1256 VTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIP 1315
I EKVGIVGRTGAGKSSL LFR++E EG+I ID I +IGLHDLR K++IIP
Sbjct: 1063 ALIKSQEKVGIVGRTGAGKSSLISALFRLSEP-EGKIWIDKILTTEIGLHDLRKKMSIIP 1121
Query: 1316 QDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQ 1375
Q+PVLF+G++R NLDPF++++DEE+W +L+ LK+ + LP K+D E AE G N SVGQ
Sbjct: 1122 QEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQ 1181
Query: 1376 RQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDY 1435
RQLVCLARA+LRK +IL++DEATA VD TD+LIQ IR +F CTVLTIAHRLNTI+D
Sbjct: 1182 RQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDS 1241
Query: 1436 TRVIVLDKGEIQEYGAPSDLLQQR-GLFYSMAKDAG 1470
+++VLD G ++EY P LLQ + LFY M + G
Sbjct: 1242 DKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLG 1277
Score = 42.7 bits (99), Expect = 0.003
Identities = 29/119 (24%), Positives = 56/119 (47%), Gaps = 4/119 (3%)
Query: 697 KVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKG 756
K++ +A G N S GQ+Q V LARA+ I + D+ + VD + I + + +
Sbjct: 1165 KMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKI---RE 1221
Query: 757 MLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGS-YQELLARDGAFAEFLRTYASTE 814
+ T + + H ++ + D I+V+ G++ E Y L ++ F + ++ E
Sbjct: 1222 KFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLGKAE 1280
>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
Length = 1359
Score = 615 bits (1585), Expect = e-175
Identities = 421/1385 (30%), Positives = 678/1385 (48%), Gaps = 202/1385 (14%)
Query: 207 PCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECA 266
P P A LS TF W+T ++V+GYRQ L L L+ D+S+ W +E A
Sbjct: 43 PNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVA 102
Query: 267 KTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFL 326
+ P+K SL V++K L
Sbjct: 103 RV-----------------------------------GPEKA---SLSHVVWKFQRTRVL 124
Query: 327 MSFFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYF 385
M + +M GP IL +++ T W G + LF T + +
Sbjct: 125 MDIVANILCIIMAAIGPVILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAW 184
Query: 386 HICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIW 445
I + + +R+K A+ V+ +++ +VGE++N++S D+ + A + +
Sbjct: 185 AINYRTAIRLKVALSTLVFEN--LVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPA 242
Query: 446 SAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLM 505
+ P+ ++ + LGP+ L G++V V+ +PV MA ++ + + D R++ M
Sbjct: 243 TIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTM 302
Query: 506 NEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTF 565
NE L I+++K+YAWE +F + + IR+ E K+L+K+ ++ + + + + T
Sbjct: 303 NEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTL 362
Query: 566 AVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEEL 625
+ ++ + L A AF +A+FN+++F + ILP I ++ +A+VSL+R++ L +
Sbjct: 363 SCHILLRRK--LTAPVAFSVIAMFNVMKFSIAILPFSIKAMAEANVSLRRMKKILI--DK 418
Query: 626 EPDSIERRPVKDGGGTNSITVRNATFTW-----------------------------ARS 656
P S +P + + NAT TW +
Sbjct: 419 SPPSYITQPEDP---DTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSER 475
Query: 657 DPP----------------TLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEG 700
PP L+ I+F + +G ++ + G VG GKSSLL+ALL +M +G
Sbjct: 476 SPPAKGATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKG 535
Query: 701 HVAIKG----------------------------------VNLSGGQKQRVSL------- 719
VA+ G V + G QK +L
Sbjct: 536 VVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTE 595
Query: 720 ------------------ARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNK 761
ARAVYS+ +YL DDPLSAVDAHVGKH+FE I K L+ K
Sbjct: 596 IGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECI--KKTLRGK 653
Query: 762 TRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEE 821
T +LVTH + +L D +I++ G+I E G+++EL+ G +A+ + Q +D E
Sbjct: 654 TVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGL-QFKDPEH 712
Query: 822 NGVTGVSGPGKEA---KQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKA 878
+ KE+ ++ + G++V ++ + + S + S D
Sbjct: 713 LYNAAMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVD-------------- 758
Query: 879 EAKKEETWKLMEADKAQTGQVKLSVYWDYMKAI-GLFISFLSIFLFMCNHVSALASNYWL 937
K +L++ + Q G V Y Y+KA G +S ++FLF+ SA SN+WL
Sbjct: 759 --TKVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWL 816
Query: 938 SLWTD-------DPIVNGTQEHTKVRLSVYGA---LGISQGIAVFGYSMAVSIG------ 981
LW D P N T L+ G + VF V+ G
Sbjct: 817 GLWLDKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKT 876
Query: 982 GILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFN 1041
++AS LH + IL+SPMSFF+ TP+G L+NRFSK++D +D +P + F+ F
Sbjct: 877 TLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFM 936
Query: 1042 VIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLL 1101
V+ +++ P +++ L + +F + R + ++LK++E+VSRSP ++H ++
Sbjct: 937 VVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQ 996
Query: 1102 GVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVI 1161
G+ +I A+ ++E I L + A RW A+R++ + N + AL +
Sbjct: 997 GLGIIHAYGKKESCITYHLLYFN----------CALRWFALRMDVLMNILTFTVALLVTL 1046
Query: 1162 SRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQIQ 1220
S S+S GLS+SY +Q++ L VR +E + +VE L+EY T E ++
Sbjct: 1047 SFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLK 1106
Query: 1221 ETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLG 1280
P WP G + FR+Y +RYR++ VL +N+ I G+ VGIVGRTG+GKSSL +
Sbjct: 1107 VGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMA 1166
Query: 1281 LFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEV 1340
LFR+ E A G I ID ++I + L DLR K+T+IPQDPVLF G++R NLDPF ++DE +
Sbjct: 1167 LFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEML 1226
Query: 1341 WTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAA 1400
W LE ++D + LP+KL E E GEN SVG+RQL+C+ARALLR +KI++LDEATA+
Sbjct: 1227 WQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATAS 1286
Query: 1401 VDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG 1460
+D +TD L+Q+TI+ F+ CTVLTIAHRLNT+++ V+V++ G++ E+ P L ++
Sbjct: 1287 MDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPD 1346
Query: 1461 LFYSM 1465
++M
Sbjct: 1347 SAFAM 1351
>gi|221316556 ATP-binding cassette, sub-family C, member 3 isoform 2
[Homo sapiens]
Length = 572
Score = 589 bits (1518), Expect = e-168
Identities = 292/557 (52%), Positives = 387/557 (69%), Gaps = 13/557 (2%)
Query: 8 SADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQM 67
S + WD N++ +T NPD T CFQN++L WVPC YLW P Y LYL H RGYI +
Sbjct: 7 SGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIIL 66
Query: 68 TPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLE 127
+ L+K K LG LLW V WADLFYSF G APVF V+P ++G+TMLLAT LIQ E
Sbjct: 67 SHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYE 126
Query: 128 RRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLV 187
R +GVQSSG+++ FW + +VCA+ RSKI+ A E D FR TFY++F+L+L L+
Sbjct: 127 RLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALI 186
Query: 188 LSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKE 247
L+CF ++ P FS DPNP PE+SA FLSR+ FWW T + + GYR PLE DLWSL +E
Sbjct: 187 LACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEE 246
Query: 248 DTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQK 307
D S+ VV L++ W+K+ +T + K A P ++ A+ E E L+ P+
Sbjct: 247 DRSQMVVQQLLEAWRKQEKQTARH--------KASAAPGKN----ASGEDEVLLGARPRP 294
Query: 308 EWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYT 367
PS K L TFG FL+S FK I DL+ F PQ+L +LI+F+++ AP W G+
Sbjct: 295 R-KPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVA 353
Query: 368 VLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLM 427
L+F+ + +Q+L+L Y+H FV+G++ +T ++G +YRKALVITNS +++STVGEIVNLM
Sbjct: 354 GLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLM 413
Query: 428 SVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKT 487
SVDAQRFMDLA ++N++WSAPLQ+ILA+Y LW NLGPSVLAGVA MVL++P+N +A+K
Sbjct: 414 SVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKM 473
Query: 488 KTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSA 547
+ +QV MK KD+RIKLM+EILNGIKVLKLYAWE +F +V IRQ EL++L+ +AYL
Sbjct: 474 RAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHT 533
Query: 548 VGTFTWVCTPFLVALCT 564
TFTW+C+PFLV L T
Sbjct: 534 TTTFTWMCSPFLVRLGT 550
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 573 bits (1476), Expect = e-163
Identities = 389/1240 (31%), Positives = 638/1240 (51%), Gaps = 106/1240 (8%)
Query: 306 QKEWNPS--LFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQG 363
Q W L++ LY FG +L K + ++ FSGP +L LL+ F+ + + P G
Sbjct: 221 QAHWQEGARLWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQEPLSHG 280
Query: 364 YFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEI 423
Y + L A L ++ +QY + + ++ + AV+ +Y KAL + S + GE
Sbjct: 281 LLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPSRPPT---GEA 337
Query: 424 VNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVM 483
+NL+ D++R ++ A + W PLQ+ + LYLL+ +G + + G+ + +L+VPVN V+
Sbjct: 338 LNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVI 397
Query: 484 AMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSA 543
A + ++ KD R+KL+ E+L+GI+V+K WE A +V A R EL L+
Sbjct: 398 ATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIK 457
Query: 544 YLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVI 603
YL A + W P ++++ F YV + L A F +LAL +L PLN P VI
Sbjct: 458 YLDAACVYLWAALPVVISIVIFITYVLMGHQ--LTATKVFTALALVRMLILPLNNFPWVI 515
Query: 604 SSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGG--------------TNSITVRNA 649
+ +++A VSL R+++FL P + G + + + A
Sbjct: 516 NGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPSTVLELHGA 575
Query: 650 TFTWARSDPPTLNGITF----SIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIK 705
F+W DP + TF + +G LV +VG+VGCGKSSLL+A+ E+ ++ GHVA++
Sbjct: 576 LFSW---DPVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVR 632
Query: 706 GVNLSGG---QKQRVSLARAVYSNA------DIYLFDDPLSAVDAHVGKHIF----ENVI 752
G++ G Q+ + A + N D L+ + L A + I + +
Sbjct: 633 GLSKGFGLATQEPWIQFA-TIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEV 691
Query: 753 GPKGMLKN---KTRILVTHSM---SYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEF 806
G KG+ + + RI + ++ L +D + ++ ++ +L
Sbjct: 692 GEKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRL 751
Query: 807 LRTYASTEQEQ-DA---EENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYS 862
L T+ + E+ DA E G +GP E + + + K S S +
Sbjct: 752 LCTHRTEYLERADAVLLMEAGRLIRAGPPSEI------LPLVQAVPKAWAENGQESDSAT 805
Query: 863 GDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFL 922
++ T E E ++ + +L++ + + G V L VY Y KA+G ++ +F
Sbjct: 806 AQSVQNPEKTKE--GLEEEQSTSGRLLQEESKKEGAVALHVYQAYWKAVGQGLALAILFS 863
Query: 923 FMCNHVSALASNYWLSLWTDD-PIVNGTQE------------------------------ 951
+ + A+++WLS W N +QE
Sbjct: 864 LLLMQATRNAADWWLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVF 923
Query: 952 -----------HTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRS 1000
+ L+VY + + ++ + G + A+ LH LLH +L +
Sbjct: 924 PLPKAAPNGSSDIRFYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMA 983
Query: 1001 PMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIII 1060
P++FF TP+G ++NRFS ++ D +P ++ + + + ++G V+ P +++
Sbjct: 984 PVTFFNATPTGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLL 1043
Query: 1061 PPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSD 1120
PPL ++Y+ VQR Y ASSR+L+RL S++ SP+YSH +TL G+SV+RA RF ++
Sbjct: 1044 PPLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENL 1103
Query: 1121 LKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHS--LSAGLVGLSVSYS 1178
++ NQ+ + + +WL +RL+ +G +V A A++ + GLVGLS+SY+
Sbjct: 1104 RLLELNQRCQFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYA 1163
Query: 1179 LQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRN 1238
L +T L+ LV ++ E +V+VERL+EY+ + P Q Q + W G VEF++
Sbjct: 1164 LSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEP-QGQPLQLGTGWLTQGGVEFQD 1222
Query: 1239 YCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGIN 1298
L YR L L + + GEK+GIVGRTG+GKSSL L LFR+ E + G +++DG++
Sbjct: 1223 VVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVD 1282
Query: 1299 IAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPD 1358
+++ L LR ++ IIPQ+P LFSG++R NLDP + D +W +L+ HL + ++++
Sbjct: 1283 TSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSM-G 1341
Query: 1359 KLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFE 1418
LD E EGG +LS+GQRQL+CLARALL KIL +DEATA+VD +TD L+Q TI +F
Sbjct: 1342 GLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFA 1401
Query: 1419 DCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1458
+ TVLTIAHRLNTI++ RV+VL G + E +P+ L Q
Sbjct: 1402 NKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQ 1441
Score = 51.2 bits (121), Expect = 7e-06
Identities = 36/140 (25%), Positives = 70/140 (50%), Gaps = 5/140 (3%)
Query: 684 KSSLLSALLAEMDKVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHV 743
K LS ++ M ++G + G +LS GQ+Q + LARA+ ++A I D+ ++VD
Sbjct: 1329 KQCHLSEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKT 1388
Query: 744 GKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAF 803
+ + + + NKT + + H ++ + D ++V+ G++ E+ S L R+
Sbjct: 1389 DQLLQQTIC---KRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATL--RNQPH 1443
Query: 804 AEFLRTYASTEQEQDAEENG 823
+ F + S++Q A G
Sbjct: 1444 SLFQQLLQSSQQGVPASLGG 1463
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 542 bits (1396), Expect = e-153
Identities = 318/794 (40%), Positives = 466/794 (58%), Gaps = 54/794 (6%)
Query: 690 ALLAEMDKVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFE 749
A+L D E + +G NLSGGQ+QR+SLARA+YS+ IY+ DDPLSA+DAHVG HIF
Sbjct: 668 AILPSSDLTE--IGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFN 725
Query: 750 NVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRT 809
+ I + LK+KT + VTH + YL D +I M G I+E G+++EL+ +G +A
Sbjct: 726 SAI--RKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNN 783
Query: 810 YASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHH 869
E E N SG K+++ D K
Sbjct: 784 LLLGETPP-VEINSKKETSGSQKKSQ---------DKGPK-------------------- 813
Query: 870 NSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIF-LFMCNHV 928
T ++K +A K E +L++ ++ G V SVY Y++A G ++FL I LFM N
Sbjct: 814 --TGSVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVG 871
Query: 929 SALASNYWLSLWTDDPIVNGTQ---EHTKVRLSVYGALGISQGIAVFGYSMAVSI----- 980
S S +WLS W N T T V S+ + +++ SMAV +
Sbjct: 872 STAFSTWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAI 931
Query: 981 -------GGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIK 1033
G + AS LH +L ILRSPM FF+ TP+G ++NRFSK++D VD +P +
Sbjct: 932 RGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAE 991
Query: 1034 MFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVY 1093
MF+ ++ V +I P + + PL +++ + R+LKRL+++++SP
Sbjct: 992 MFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFL 1051
Query: 1094 SHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVL 1153
SH ++ G++ I A+ + + F+H+ +D+NQ ++ A RWLAVRL+ + ++
Sbjct: 1052 SHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALIT 1111
Query: 1154 FAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-E 1212
L V+ + GL++SY++Q+T + VR++SE E +VER+ Y +T
Sbjct: 1112 TTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLS 1171
Query: 1213 KEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGA 1272
EAP +I+ AP WPQ G V F N +RYRE+L VL+ ++ TI EK+GIVGRTG+
Sbjct: 1172 LEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGS 1231
Query: 1273 GKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPF 1332
GKSSL + LFR+ E + G I IDG+ I+ IGL DLR K++IIPQ+PVLFSG++R NLDPF
Sbjct: 1232 GKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPF 1291
Query: 1333 SQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKIL 1392
+QY+++++W +LE H+K+ ++ LP KL+ E E G+N SVG+RQL+C+ARALLR KIL
Sbjct: 1292 NQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKIL 1351
Query: 1393 VLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAP 1452
+LDEATAA+D ETD LIQ TIR F DCT+LTIAHRL+T++ R++VL +G++ E+ P
Sbjct: 1352 ILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTP 1411
Query: 1453 SDLL-QQRGLFYSM 1465
S LL FY+M
Sbjct: 1412 SVLLSNDSSRFYAM 1425
Score = 146 bits (369), Expect = 1e-34
Identities = 113/450 (25%), Positives = 210/450 (46%), Gaps = 49/450 (10%)
Query: 209 PESSASFLSRITFWWITGLIVRGYRQ-PLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAK 267
P +A S +TF W++ L +++ L D+WSL+K ++S+ L + W++E +
Sbjct: 100 PVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNE 159
Query: 268 TRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLM 327
D A SL +V++ ++
Sbjct: 160 V----------GPDAA----------------------------SLRRVVWIFCRTRLIL 181
Query: 328 SFFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFH 386
S I L FSGP + K L+++ T++ + L +T +++ L +
Sbjct: 182 SIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWA 241
Query: 387 ICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWS 446
+ + +G+R++ A++ ++K L + N KS +GE++N+ S D QR + A +++
Sbjct: 242 LNYRTGVRLRGAILTMAFKKILKLKNIKEKS--LGELINICSNDGQRMFEAAAVGSLLAG 299
Query: 447 APLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMN 506
P+ IL + + LGP+ G AV +L P + T ++ + + D R++ MN
Sbjct: 300 GPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMN 359
Query: 507 EILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFA 566
E+L IK +K+YAW AF V IR+EE ++L+K+ Y ++ + ++ TF+
Sbjct: 360 EVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFS 419
Query: 567 VYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELE 626
V++T+ + L A AF + +FN + F L + P + S+ +ASV++ R + EE+
Sbjct: 420 VHMTLGFD--LTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVH 477
Query: 627 PDSIERRPVKDGGGTNSITVRNATFTWARS 656
I+ +P I ++NAT W S
Sbjct: 478 --MIKNKPASP---HIKIEMKNATLAWDSS 502
Score = 90.1 bits (222), Expect = 1e-17
Identities = 66/215 (30%), Positives = 99/215 (46%), Gaps = 14/215 (6%)
Query: 1247 LDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHD 1306
L L I++ I G+ VGI G G+GK+SL + EG I I G
Sbjct: 574 LQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT--------- 624
Query: 1307 LRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAE 1366
+ Q + + +LR N+ +Y +E + L L+ ++ LP E E
Sbjct: 625 ----FAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGE 680
Query: 1367 GGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTI 1425
G NLS GQRQ + LARAL I +LD+ +A+D + + S IR + TVL +
Sbjct: 681 RGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFV 740
Query: 1426 AHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG 1460
H+L ++D VI + +G I E G +L+ G
Sbjct: 741 THQLQYLVDCDEVIFMKEGCITERGTHEELMNLNG 775
Score = 50.4 bits (119), Expect = 1e-05
Identities = 24/47 (51%), Positives = 32/47 (68%)
Query: 660 TLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG 706
TL+ I I EG LV + G VG GK+SL+SA+L +M +EG +AI G
Sbjct: 577 TLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISG 623
Score = 45.1 bits (105), Expect = 5e-04
Identities = 72/363 (19%), Positives = 146/363 (40%), Gaps = 34/363 (9%)
Query: 366 YTVLLFVTACLQTLVLHQYFHICFVSG-MRIKTAVIGAVYRKALVITNSARKSSTVGEIV 424
Y ++ + L+L + FV G +R + + ++R+ L ++ G I+
Sbjct: 913 YYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRIL 972
Query: 425 NLMSVDAQRFMDLATYINMIWSAPL---QVILALYLLWLNLG--PSVLAGVAVMVLMVPV 479
N S D + + + A + VIL + + + G P L V +V++ V
Sbjct: 973 NRFSKDMDE-----VDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSV 1027
Query: 480 NAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNGIKVLK-LYAWELAFKDKVLAIRQEEL 536
+++ + +K DN + ++ I + I+ L ++A+ K + R +EL
Sbjct: 1028 LHIVSRVL----IRELKRLDNITQSPFLSHITSSIQGLATIHAYN---KGQEFLHRYQEL 1080
Query: 537 KVLKKSAYLSAVGTFTWVCTPF----LVALCTFAVYVTIDENNILDAQTAFV---SLALF 589
++ + W+ + + T + + + I A ++ L
Sbjct: 1081 LDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLT 1140
Query: 590 NILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELE-PDSIERR-PVKDGGGTNSITVR 647
+ +F + + S S++R+ ++ LE P I+ + P D +T
Sbjct: 1141 GLFQFTVRLA----SETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFE 1196
Query: 648 NATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGV 707
NA + + P L ++F+I + +VG+ G GKSSL AL ++ G + I GV
Sbjct: 1197 NAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGV 1256
Query: 708 NLS 710
+S
Sbjct: 1257 RIS 1259
Score = 45.1 bits (105), Expect = 5e-04
Identities = 30/120 (25%), Positives = 59/120 (49%), Gaps = 5/120 (4%)
Query: 697 KVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKG 756
K+E V G N S G++Q + +ARA+ + I + D+ +A+D I E + +
Sbjct: 1318 KLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETI---RE 1374
Query: 757 MLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQE 816
+ T + + H + + D I+V++ G++ E + LL+ D + F +A+ E +
Sbjct: 1375 AFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDS--SRFYAMFAAAENK 1432
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 507 bits (1305), Expect = e-143
Identities = 292/772 (37%), Positives = 449/772 (58%), Gaps = 44/772 (5%)
Query: 705 KGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRI 764
+G+NLSGGQ+QR+S+ARA+Y +A++ DDP SA+D H+ H+ + I +T +
Sbjct: 825 RGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVV 884
Query: 765 LVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGV 824
LVTH + YLP D II M G I G+ ++ + E +T + Q+Q+ E+ V
Sbjct: 885 LVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMN-RQDQELEKETV 943
Query: 825 TGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEE 884
T ++A + G L R +SS D E ++ EA + E
Sbjct: 944 TE-----RKATEPPQG----------LSRAMSSRDGLLQD--------EEEEEEEAAESE 980
Query: 885 TWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDP 944
+ + Q ++ Y+ + G+ + L +F + H+ +A +YWL+ WTD
Sbjct: 981 EDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSA 1040
Query: 945 IV--------NGTQEHT------KVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLH 990
+ + +QE T + +V +LGI + S+ V G+ ++ LH
Sbjct: 1041 LTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGI---VLCLVTSVTVEWTGLKVAKRLH 1097
Query: 991 VDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVIL 1050
LL+ I+ +PM FFE TP G+++NRFS + +T+D IP ++ S + A VI
Sbjct: 1098 RSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVIS 1157
Query: 1051 LATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFE 1110
TP+ + + PL ++ +F+Q+++ +SR L++L+ ++ P+ SHF ET+ G++ IRAF
Sbjct: 1158 YVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFR 1217
Query: 1111 EQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVIS--RHSLSA 1168
+ RF + D N A ANRWL VR+E +G C+VL AA+ ++ + LSA
Sbjct: 1218 YEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSA 1277
Query: 1169 GLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEA-PWQIQETAPPSS 1227
GLVGL ++Y+L V+ YLNW+VR ++ME + AV+R+ +TE E+ + + P +
Sbjct: 1278 GLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKN 1337
Query: 1228 WPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINES 1287
WP G+++ +N +RY L VL+H+N I G+K+GI GRTG+GKSS +L FR+ ++
Sbjct: 1338 WPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDT 1397
Query: 1288 AEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELA 1347
EG IIIDGI+IAK+ LH LR +++II QDPVLFSG++R NLDP + SD +W +LE+A
Sbjct: 1398 FEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIA 1457
Query: 1348 HLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDD 1407
LK V ALP LD EGGEN S GQRQL CLARA +RKT I ++DEATA++D+ T++
Sbjct: 1458 QLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATEN 1517
Query: 1408 LIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQR 1459
++Q + T F D TV+TIAHR++TI+ VIVL +G I E+ P LL ++
Sbjct: 1518 ILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
Score = 211 bits (538), Expect = 3e-54
Identities = 154/553 (27%), Positives = 253/553 (45%), Gaps = 102/553 (18%)
Query: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVK---NWKKECAKTRK 270
+ LS+ T+WW+ I +++P+ DL ++ K +P+ ++ N+++ C
Sbjct: 223 NLLSKGTYWWMNAFIKTAHKKPI---DLRAIGK-------LPIAMRALTNYQRLCEAFDA 272
Query: 271 QPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFF 330
Q K + ++ ++++ L FG ++S
Sbjct: 273 QVRKDIQGTQGAR----------------------------AIWQALSHAFGRRLVLSST 304
Query: 331 FKAIHDLMMFSGPQILKLLIKFV---NDTKAPDWQ---------------GYFYTVLLFV 372
F+ + DL+ F+GP + ++ + ND P Q Y VLLF+
Sbjct: 305 FRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFL 364
Query: 373 TACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVD 430
LQ L +++ +G+ ++ A+ +Y K + ++ S + T G+I NL+++D
Sbjct: 365 ALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAID 424
Query: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
+ M +W+ P+Q+I+ + LL+ LG S L G AV++L+ PV +A K
Sbjct: 425 TNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQA 484
Query: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
Q + ++ + R+K NE+L GIK+LKLYAWE F+ +V R++E+ L+ A +++
Sbjct: 485 QRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISI 544
Query: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQAS 610
F P L TF +V+ + AF SL+LF+IL PL +L V+ S V+A
Sbjct: 545 FMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKAL 604
Query: 611 VSLKRLRIFLSHEELEPDSI-----------------------ERRPVK----------- 636
VS+++L FLS E+ + +RP +
Sbjct: 605 VSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQ 664
Query: 637 ------DGGGTN-SITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLS 689
DG N + + FTW PTL+ IT IP G L +VGQVGCGKSSLL
Sbjct: 665 SLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLL 724
Query: 690 ALLAEMDKVEGHV 702
A L EM KV G V
Sbjct: 725 AALGEMQKVSGAV 737
Score = 74.7 bits (182), Expect = 6e-13
Identities = 60/220 (27%), Positives = 101/220 (45%), Gaps = 16/220 (7%)
Query: 1251 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLH----- 1305
L +I + I G+ IVG+ G GKSSL L + G + + ++IG
Sbjct: 696 LSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPER 755
Query: 1306 ------DLRFK--ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALP 1357
D+R + + Q P L + ++ N+ S ++ + +E L+ + LP
Sbjct: 756 ETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILP 815
Query: 1358 DKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLE-TDDLIQSTIRTQ 1416
+ E G NLS GQRQ + +ARAL + ++ LD+ +A+D+ +D L+Q+ I
Sbjct: 816 HGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILEL 875
Query: 1417 FED--CTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSD 1454
D TV+ + H+L + +I + G IQ G D
Sbjct: 876 LRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKD 915
Score = 54.7 bits (130), Expect = 7e-07
Identities = 77/364 (21%), Positives = 154/364 (42%), Gaps = 39/364 (10%)
Query: 366 YTVL--LFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEI 423
+TVL L + CL T V ++ +G+++ + ++ + ++ +++ +G I
Sbjct: 1067 FTVLCSLGIVLCLVTSVTVEW------TGLKVAKRLHRSLLNRIILAPMRFFETTPLGSI 1120
Query: 424 VNLMSVDAQRF-MDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAV 482
+N S D + + + + + L + AL ++ S + V +V ++P+ V
Sbjct: 1121 LNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVI------SYVTPV-FLVALLPLAIV 1173
Query: 483 MAMKTKTYQVAH--MKSKDNRIKL-----MNEILNGIKVLKLYAWELAFKDKVLAIRQEE 535
K ++VA ++ D+ +L E + G+ ++ + +E F+ K+L
Sbjct: 1174 CYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSN 1233
Query: 536 LKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNI-LDAQTAFVSLALFNILRF 594
S +L+A + V ++ A VT N++ + V L L L
Sbjct: 1234 NIA---SLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMV 1290
Query: 595 PLNILPMVISSIVQASVSL---KRLRIFL-----SHEELEPDSIERRPVKDGGGTNSITV 646
N L ++ ++ + L KR+ L S+E L S+ + D G I +
Sbjct: 1291 S-NYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQG---KIQI 1346
Query: 647 RNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG 706
+N + + S P L + I G + + G+ G GKSS A +D EGH+ I G
Sbjct: 1347 QNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDG 1406
Query: 707 VNLS 710
++++
Sbjct: 1407 IDIA 1410
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 505 bits (1301), Expect = e-142
Identities = 284/774 (36%), Positives = 449/774 (58%), Gaps = 46/774 (5%)
Query: 705 KGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLK----- 759
+G+NLSGGQ+QR+ +ARA+Y N +I DDP SA+D H+ H+ + +G+LK
Sbjct: 808 RGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQ-----EGILKFLQDD 862
Query: 760 NKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDA 819
+T +LVTH + YL D II M G + G+ +++ +D E +T + Q+Q+
Sbjct: 863 KRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMN-RQDQEL 921
Query: 820 EENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAE 879
E++ EA Q L+R+ + YS + E ++ E
Sbjct: 922 EKD---------MEADQTT------------LERKTLRRAMYSREAKAQMEDEDEEEEEE 960
Query: 880 AKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSL 939
+++ M ++ W Y+ + G F+ L IF + H +A +YWL+
Sbjct: 961 EDEDDN---MSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLAT 1017
Query: 940 WTDDPIVNGT----QEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLH 995
WT + +N T Q + S+ GI + S+ V G+ A++ LH +LL+
Sbjct: 1018 WTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVT---SLTVEWMGLTAAKNLHHNLLN 1074
Query: 996 SILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPI 1055
I+ P+ FF+ TP G ++NRFS + + +D IP ++ S + A +I ATP+
Sbjct: 1075 KIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPV 1134
Query: 1056 AAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERF 1115
+ + PLG+ ++F+Q+++ +S+ L+ L+ ++ P+ HF+ET G++ IRAF + RF
Sbjct: 1135 FLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRF 1194
Query: 1116 IHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSV 1175
+ D N AY ANRWL VR + +G CIVL A++ ++ S ++GLVGL +
Sbjct: 1195 KQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISG--SSNSGLVGLGL 1252
Query: 1176 SYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEA-PWQIQETAPPSSWPQVGRV 1234
Y+L +T YLNW+VR +++E + AV+++ + E E + + P WPQ G +
Sbjct: 1253 LYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEI 1312
Query: 1235 EFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIII 1294
+ + C+RY +L VL+H+ I G+KVGI GRTG+GKSSL+L FR+ + +G+I+I
Sbjct: 1313 KIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVI 1372
Query: 1295 DGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVS 1354
DGI+I+K+ LH LR +++II QDP+LFSGS+R NLDP + +D+ +W +LE+A LK+ V
Sbjct: 1373 DGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVK 1432
Query: 1355 ALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIR 1414
+LP LD EGGEN SVGQRQL CLARA +RK+ IL++DEATA++D+ T++++Q +
Sbjct: 1433 SLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVM 1492
Query: 1415 TQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL-QQRGLFYSMAK 1467
T F D TV+TIAHR++TI+ VIV+ +G I EY P LL Q+ G+F S +
Sbjct: 1493 TAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVFASFVR 1546
Score = 222 bits (565), Expect = 2e-57
Identities = 166/556 (29%), Positives = 259/556 (46%), Gaps = 98/556 (17%)
Query: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 273
+ LS+ T+WW+ LI+ +++P+ DL ++ K + + V V C K
Sbjct: 221 NLLSKATYWWMNTLIISAHKKPI---DLKAIGKLPIAMRAVTNYV------CLK------ 265
Query: 274 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKA 333
DA EE + + P + PS++ +Y+ FG L+S F+
Sbjct: 266 ------------------DAYEEQKKKVADHPNR--TPSIWLAMYRAFGRPILLSSTFRY 305
Query: 334 IHDLMMFSGPQILKLLIKFVNDTKAPD----------------WQGYFYTVLLFVTACLQ 377
+ DL+ F+GP + +++ VN+T+ Y VLLF+ LQ
Sbjct: 306 LADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQ 365
Query: 378 TLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVDAQRFM 435
L +++ +G+ ++ A++ +Y K L ++ S + T+G+I NL++++ + M
Sbjct: 366 RTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLM 425
Query: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
+W+ P+Q+I+ + LL+ LG S L G AV+VL+ P+ +A K Q + +
Sbjct: 426 WFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTL 485
Query: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
R+K NEIL GIK+LKLYAWE F V R +EL LK A +++ F
Sbjct: 486 DYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAA 545
Query: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
P L TF + NN+ A+ AF SL+LF+IL PL +L V+ V+A +S+++
Sbjct: 546 IPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQK 604
Query: 616 LRIFL-----------------------SHEELEPDSIER------------------RP 634
L FL H ++P +I R RP
Sbjct: 605 LNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRP 664
Query: 635 VKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAE 694
+ +I V N F+W S TL+ I IP G L +VGQVGCGKSSLL A+L E
Sbjct: 665 AET--EDIAIKVTNGYFSWG-SGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGE 721
Query: 695 MDKVEGHVAIKGVNLS 710
M +EG V VN S
Sbjct: 722 MQTLEGKVHWSNVNES 737
Score = 90.1 bits (222), Expect = 1e-17
Identities = 110/482 (22%), Positives = 205/482 (42%), Gaps = 73/482 (15%)
Query: 1028 IPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLK-RLES 1086
+P I M + L+N++G+ ++ AA+I+ + YF + A L E
Sbjct: 437 MPVQIIMGVILLYNLLGSSALVG-----AAVIVLLAPIQYFIATKLAEAQKSTLDYSTER 491
Query: 1087 VSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLEC 1146
+ ++ NE L G+ +++ + + F V+E + S+ L L
Sbjct: 492 LKKT------NEILKGIKLLKLYAWEHIFCKS----VEETRMKELSSLKTFA-LYTSLSI 540
Query: 1147 VGNCIVLFAALFAVISRHSLSAG--------LVGLSVSYSLQVTTYL-NWLVRMSSEMET 1197
N + AA+ A H+ ++G LS+ + L +L + +VR + +
Sbjct: 541 FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKA-- 598
Query: 1198 NIVAVERLKEY--SETEKEAPWQIQETAPPS--------------SWPQVGRVEFRNY-- 1239
I++V++L E+ S+ + W+ E++ P + Q GR +Y
Sbjct: 599 -IISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQ 657
Query: 1240 ---CLRYREDLDFVLR----------------HINVTINGGEKVGIVGRTGAGKSSLTLG 1280
LR E D ++ +I++ I G+ IVG+ G GKSSL L
Sbjct: 658 STRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLA 717
Query: 1281 LFRINESAEGEIIIDGINIAKIGLHDLR----FKITIIPQDPVLFSGSLRMNLDPFSQYS 1336
+ ++ EG++ +N ++ R + + Q P L + ++ N+ S ++
Sbjct: 718 ILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFN 777
Query: 1337 DEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDE 1396
+ + L+ + LP E E G NLS GQRQ +C+ARAL + T I+ LD+
Sbjct: 778 KQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDD 837
Query: 1397 ATAAVDLE-TDDLIQSTIRTQFED--CTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPS 1453
+A+D+ +D L+Q I +D T++ + H+L + +I + G + G
Sbjct: 838 PFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLK 897
Query: 1454 DL 1455
D+
Sbjct: 898 DI 899
Score = 52.0 bits (123), Expect = 4e-06
Identities = 102/479 (21%), Positives = 185/479 (38%), Gaps = 71/479 (14%)
Query: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328
RK + +YS + AQ ++ + + EE E + + + K+ +KT Y
Sbjct: 934 RKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRT----KMPWKTCWRYLTSG 989
Query: 329 FFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYF-----------YTVLLFVTACLQ 377
FF I LM+FS ++LK + D W + Y V F C
Sbjct: 990 GFFLLI--LMIFS--KLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGA 1045
Query: 378 TLVLHQYFHICFVSGMRIKTAVIGA-------VYRKALVITNSARKSSTVGEIVNLMSVD 430
+ L C V+ + ++ + A + K ++ ++ +G I+N S D
Sbjct: 1046 GIFL------CLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSAD 1099
Query: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLN-LGPSVLAGVAVMVLMVPVNAVMAMKTKT 489
I+ L+ + LL L+ +G A +V ++P+ K
Sbjct: 1100 TN-------IIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKY 1152
Query: 490 YQVAH--MKSKDNRIKL-----MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKS 542
++VA ++ D+ +L +E G+ ++ + E FK ++L EL
Sbjct: 1153 FRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRML-----ELTDTNNI 1207
Query: 543 AYL--SAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
AYL SA + V T +L A + + + + V L L L N L
Sbjct: 1208 AYLFLSAANRWLEVRTDYLGACIVLTASIASISGS---SNSGLVGLGLLYALTIT-NYLN 1263
Query: 601 MVISSIVQASVSL---KRLRIFLSHEE------LEPDSIERRPVKDGGGTNSITVRNATF 651
V+ ++ V + K++ FL+ E ++P + ++G I + +
Sbjct: 1264 WVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEG----EIKIHDLCV 1319
Query: 652 TWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNLS 710
+ + P L + I G V + G+ G GKSSL A +D +G + I G+++S
Sbjct: 1320 RYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDIS 1378
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 495 bits (1274), Expect = e-139
Identities = 280/772 (36%), Positives = 447/772 (57%), Gaps = 46/772 (5%)
Query: 705 KGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLK----- 759
+G+NLSGGQ+QR+ +ARA+Y N +I DDP SA+D H+ H+ + +G+LK
Sbjct: 772 RGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQ-----EGILKFLQDD 826
Query: 760 NKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDA 819
+T +LVTH + YL D II M G + G+ +++ +D E +T + Q+Q+
Sbjct: 827 KRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMN-RQDQEL 885
Query: 820 EENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAE 879
E++ EA Q L+R+ + YS + E ++ E
Sbjct: 886 EKD---------MEADQTT------------LERKTLRRAMYSREAKAQMEDEDEEEEEE 924
Query: 880 AKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSL 939
+++ M ++ W Y+ + G F+ L IF + H +A +YWL+
Sbjct: 925 EDEDDN---MSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLAT 981
Query: 940 WTDDPIVNGT----QEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLH 995
WT + +N T Q + S+ GI + S+ V G+ A++ LH +LL+
Sbjct: 982 WTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVT---SLTVEWMGLTAAKNLHHNLLN 1038
Query: 996 SILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPI 1055
I+ P+ FF+ TP G ++NRFS + + +D IP ++ S + A +I ATP+
Sbjct: 1039 KIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPV 1098
Query: 1056 AAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERF 1115
+ + PLG+ ++F+Q+++ +S+ L+ L+ ++ P+ HF+ET G++ IRAF + RF
Sbjct: 1099 FLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRF 1158
Query: 1116 IHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSV 1175
+ D N AY ANRWL VR + +G CIVL A++ ++ S ++GLVGL +
Sbjct: 1159 KQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISG--SSNSGLVGLGL 1216
Query: 1176 SYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEA-PWQIQETAPPSSWPQVGRV 1234
Y+L +T YLNW+VR +++E + AV+++ + E E + + P WPQ G +
Sbjct: 1217 LYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEI 1276
Query: 1235 EFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIII 1294
+ + C+RY +L VL+H+ I G+KVGI GRTG+GKSSL+L FR+ + +G+I+I
Sbjct: 1277 KIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVI 1336
Query: 1295 DGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVS 1354
DGI+I+K+ LH LR +++II QDP+LFSGS+R NLDP + +D+ +W +LE+A LK+ V
Sbjct: 1337 DGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVK 1396
Query: 1355 ALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIR 1414
+LP LD EGGEN SVGQRQL CLARA +RK+ IL++DEATA++D+ T++++Q +
Sbjct: 1397 SLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVM 1456
Query: 1415 TQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYG-APSDLLQQRGLFYSM 1465
T F D TV+TIAHR+++IMD V+V +G + E P+ L + GLF ++
Sbjct: 1457 TAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTL 1508
Score = 232 bits (592), Expect = 2e-60
Identities = 163/518 (31%), Positives = 256/518 (49%), Gaps = 58/518 (11%)
Query: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 273
+ LS+ T+WW+ LI+ +++P+ DL ++ K + + V V C K
Sbjct: 221 NLLSKATYWWMNTLIISAHKKPI---DLKAIGKLPIAMRAVTNYV------CLK------ 265
Query: 274 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKA 333
DA EE + + P + PS++ +Y+ FG L+S F+
Sbjct: 266 ------------------DAYEEQKKKVADHPNR--TPSIWLAMYRAFGRPILLSSTFRY 305
Query: 334 IHDLMMFSGPQILKLLIKFVNDTKAPD----------------WQGYFYTVLLFVTACLQ 377
+ DL+ F+GP + +++ VN+T+ Y VLLF+ LQ
Sbjct: 306 LADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQ 365
Query: 378 TLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVDAQRFM 435
L +++ +G+ ++ A++ +Y K L ++ S + T+G+I NL++++ + M
Sbjct: 366 RTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLM 425
Query: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
+W+ P+Q+I+ + LL+ LG S L G AV+VL+ P+ +A K Q + +
Sbjct: 426 WFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTL 485
Query: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
R+K NEIL GIK+LKLYAWE F V R +EL LK A +++ F
Sbjct: 486 DYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAA 545
Query: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
P L TF + NN+ A+ AF SL+LF+IL PL +L V+ V+A +S+++
Sbjct: 546 IPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQK 604
Query: 616 LRIFLSHEELEPDSI---ERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGA 672
L FL +E+ DS E + ++ V N F+W S TL+ I IP G
Sbjct: 605 LNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVVTNGYFSWG-SGLATLSNIDIRIPTGQ 663
Query: 673 LVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNLS 710
L +VGQVGCGKSSLL A+L EM +EG V VN S
Sbjct: 664 LTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNES 701
Score = 95.5 bits (236), Expect = 3e-19
Identities = 105/447 (23%), Positives = 198/447 (44%), Gaps = 39/447 (8%)
Query: 1028 IPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLK-RLES 1086
+P I M + L+N++G+ ++ AA+I+ + YF + A L E
Sbjct: 437 MPVQIIMGVILLYNLLGSSALVG-----AAVIVLLAPIQYFIATKLAEAQKSTLDYSTER 491
Query: 1087 VSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLEC 1146
+ ++ NE L G+ +++ + + F V+E + S+ L L
Sbjct: 492 LKKT------NEILKGIKLLKLYAWEHIFCKS----VEETRMKELSSLKTFA-LYTSLSI 540
Query: 1147 VGNCIVLFAALFAVISRHSLSAG--------LVGLSVSYSLQVTTYL-NWLVRMSSEMET 1197
N + AA+ A H+ ++G LS+ + L +L + +VR + +
Sbjct: 541 FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKA-- 598
Query: 1198 NIVAVERLKEY--SETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHIN 1255
I++V++L E+ S+ + W+ E++ P + N + L L +I+
Sbjct: 599 -IISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVVTNGYFSWGSGLA-TLSNID 656
Query: 1256 VTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLR----FKI 1311
+ I G+ IVG+ G GKSSL L + ++ EG++ +N ++ R + +
Sbjct: 657 IRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSV 716
Query: 1312 TIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENL 1371
Q P L + ++ N+ S ++ + + L+ + LP E E G NL
Sbjct: 717 AYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINL 776
Query: 1372 SVGQRQLVCLARALLRKTKILVLDEATAAVDLE-TDDLIQSTIRTQFED--CTVLTIAHR 1428
S GQRQ +C+ARAL + T I+ LD+ +A+D+ +D L+Q I +D T++ + H+
Sbjct: 777 SGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHK 836
Query: 1429 LNTIMDYTRVIVLDKGEIQEYGAPSDL 1455
L + +I + G + G D+
Sbjct: 837 LQYLTHADWIIAMKDGSVLREGTLKDI 863
Score = 52.0 bits (123), Expect = 4e-06
Identities = 102/479 (21%), Positives = 185/479 (38%), Gaps = 71/479 (14%)
Query: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328
RK + +YS + AQ ++ + + EE E + + + K+ +KT Y
Sbjct: 898 RKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRT----KMPWKTCWRYLTSG 953
Query: 329 FFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYF-----------YTVLLFVTACLQ 377
FF I LM+FS ++LK + D W + Y V F C
Sbjct: 954 GFFLLI--LMIFS--KLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGA 1009
Query: 378 TLVLHQYFHICFVSGMRIKTAVIGA-------VYRKALVITNSARKSSTVGEIVNLMSVD 430
+ L C V+ + ++ + A + K ++ ++ +G I+N S D
Sbjct: 1010 GIFL------CLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSAD 1063
Query: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLN-LGPSVLAGVAVMVLMVPVNAVMAMKTKT 489
I+ L+ + LL L+ +G A +V ++P+ K
Sbjct: 1064 TN-------IIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKY 1116
Query: 490 YQVAH--MKSKDNRIKL-----MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKS 542
++VA ++ D+ +L +E G+ ++ + E FK ++L EL
Sbjct: 1117 FRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRML-----ELTDTNNI 1171
Query: 543 AYL--SAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
AYL SA + V T +L A + + + + V L L L N L
Sbjct: 1172 AYLFLSAANRWLEVRTDYLGACIVLTASIASISGS---SNSGLVGLGLLYALTIT-NYLN 1227
Query: 601 MVISSIVQASVSL---KRLRIFLSHEE------LEPDSIERRPVKDGGGTNSITVRNATF 651
V+ ++ V + K++ FL+ E ++P + ++G I + +
Sbjct: 1228 WVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEG----EIKIHDLCV 1283
Query: 652 TWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNLS 710
+ + P L + I G V + G+ G GKSSL A +D +G + I G+++S
Sbjct: 1284 RYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDIS 1342
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 495 bits (1274), Expect = e-139
Identities = 280/772 (36%), Positives = 447/772 (57%), Gaps = 46/772 (5%)
Query: 705 KGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLK----- 759
+G+NLSGGQ+QR+ +ARA+Y N +I DDP SA+D H+ H+ + +G+LK
Sbjct: 808 RGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQ-----EGILKFLQDD 862
Query: 760 NKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDA 819
+T +LVTH + YL D II M G + G+ +++ +D E +T + Q+Q+
Sbjct: 863 KRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMN-RQDQEL 921
Query: 820 EENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAE 879
E++ EA Q L+R+ + YS + E ++ E
Sbjct: 922 EKD---------MEADQTT------------LERKTLRRAMYSREAKAQMEDEDEEEEEE 960
Query: 880 AKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSL 939
+++ M ++ W Y+ + G F+ L IF + H +A +YWL+
Sbjct: 961 EDEDDN---MSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLAT 1017
Query: 940 WTDDPIVNGT----QEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLH 995
WT + +N T Q + S+ GI + S+ V G+ A++ LH +LL+
Sbjct: 1018 WTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVT---SLTVEWMGLTAAKNLHHNLLN 1074
Query: 996 SILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPI 1055
I+ P+ FF+ TP G ++NRFS + + +D IP ++ S + A +I ATP+
Sbjct: 1075 KIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPV 1134
Query: 1056 AAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERF 1115
+ + PLG+ ++F+Q+++ +S+ L+ L+ ++ P+ HF+ET G++ IRAF + RF
Sbjct: 1135 FLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRF 1194
Query: 1116 IHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSV 1175
+ D N AY ANRWL VR + +G CIVL A++ ++ S ++GLVGL +
Sbjct: 1195 KQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISG--SSNSGLVGLGL 1252
Query: 1176 SYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEA-PWQIQETAPPSSWPQVGRV 1234
Y+L +T YLNW+VR +++E + AV+++ + E E + + P WPQ G +
Sbjct: 1253 LYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEI 1312
Query: 1235 EFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIII 1294
+ + C+RY +L VL+H+ I G+KVGI GRTG+GKSSL+L FR+ + +G+I+I
Sbjct: 1313 KIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVI 1372
Query: 1295 DGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVS 1354
DGI+I+K+ LH LR +++II QDP+LFSGS+R NLDP + +D+ +W +LE+A LK+ V
Sbjct: 1373 DGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVK 1432
Query: 1355 ALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIR 1414
+LP LD EGGEN SVGQRQL CLARA +RK+ IL++DEATA++D+ T++++Q +
Sbjct: 1433 SLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVM 1492
Query: 1415 TQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYG-APSDLLQQRGLFYSM 1465
T F D TV+TIAHR+++IMD V+V +G + E P+ L + GLF ++
Sbjct: 1493 TAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTL 1544
Score = 222 bits (565), Expect = 2e-57
Identities = 166/556 (29%), Positives = 259/556 (46%), Gaps = 98/556 (17%)
Query: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 273
+ LS+ T+WW+ LI+ +++P+ DL ++ K + + V V C K
Sbjct: 221 NLLSKATYWWMNTLIISAHKKPI---DLKAIGKLPIAMRAVTNYV------CLK------ 265
Query: 274 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKA 333
DA EE + + P + PS++ +Y+ FG L+S F+
Sbjct: 266 ------------------DAYEEQKKKVADHPNR--TPSIWLAMYRAFGRPILLSSTFRY 305
Query: 334 IHDLMMFSGPQILKLLIKFVNDTKAPD----------------WQGYFYTVLLFVTACLQ 377
+ DL+ F+GP + +++ VN+T+ Y VLLF+ LQ
Sbjct: 306 LADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQ 365
Query: 378 TLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVDAQRFM 435
L +++ +G+ ++ A++ +Y K L ++ S + T+G+I NL++++ + M
Sbjct: 366 RTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLM 425
Query: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
+W+ P+Q+I+ + LL+ LG S L G AV+VL+ P+ +A K Q + +
Sbjct: 426 WFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTL 485
Query: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
R+K NEIL GIK+LKLYAWE F V R +EL LK A +++ F
Sbjct: 486 DYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAA 545
Query: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
P L TF + NN+ A+ AF SL+LF+IL PL +L V+ V+A +S+++
Sbjct: 546 IPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQK 604
Query: 616 LRIFL-----------------------SHEELEPDSIER------------------RP 634
L FL H ++P +I R RP
Sbjct: 605 LNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRP 664
Query: 635 VKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAE 694
+ +I V N F+W S TL+ I IP G L +VGQVGCGKSSLL A+L E
Sbjct: 665 AET--EDIAIKVTNGYFSWG-SGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGE 721
Query: 695 MDKVEGHVAIKGVNLS 710
M +EG V VN S
Sbjct: 722 MQTLEGKVHWSNVNES 737
Score = 90.1 bits (222), Expect = 1e-17
Identities = 110/482 (22%), Positives = 205/482 (42%), Gaps = 73/482 (15%)
Query: 1028 IPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLK-RLES 1086
+P I M + L+N++G+ ++ AA+I+ + YF + A L E
Sbjct: 437 MPVQIIMGVILLYNLLGSSALVG-----AAVIVLLAPIQYFIATKLAEAQKSTLDYSTER 491
Query: 1087 VSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLEC 1146
+ ++ NE L G+ +++ + + F V+E + S+ L L
Sbjct: 492 LKKT------NEILKGIKLLKLYAWEHIFCKS----VEETRMKELSSLKTFA-LYTSLSI 540
Query: 1147 VGNCIVLFAALFAVISRHSLSAG--------LVGLSVSYSLQVTTYL-NWLVRMSSEMET 1197
N + AA+ A H+ ++G LS+ + L +L + +VR + +
Sbjct: 541 FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKA-- 598
Query: 1198 NIVAVERLKEY--SETEKEAPWQIQETAPPS--------------SWPQVGRVEFRNY-- 1239
I++V++L E+ S+ + W+ E++ P + Q GR +Y
Sbjct: 599 -IISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQ 657
Query: 1240 ---CLRYREDLDFVLR----------------HINVTINGGEKVGIVGRTGAGKSSLTLG 1280
LR E D ++ +I++ I G+ IVG+ G GKSSL L
Sbjct: 658 STRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLA 717
Query: 1281 LFRINESAEGEIIIDGINIAKIGLHDLR----FKITIIPQDPVLFSGSLRMNLDPFSQYS 1336
+ ++ EG++ +N ++ R + + Q P L + ++ N+ S ++
Sbjct: 718 ILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFN 777
Query: 1337 DEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDE 1396
+ + L+ + LP E E G NLS GQRQ +C+ARAL + T I+ LD+
Sbjct: 778 KQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDD 837
Query: 1397 ATAAVDLE-TDDLIQSTIRTQFED--CTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPS 1453
+A+D+ +D L+Q I +D T++ + H+L + +I + G + G
Sbjct: 838 PFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLK 897
Query: 1454 DL 1455
D+
Sbjct: 898 DI 899
Score = 52.0 bits (123), Expect = 4e-06
Identities = 102/479 (21%), Positives = 185/479 (38%), Gaps = 71/479 (14%)
Query: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328
RK + +YS + AQ ++ + + EE E + + + K+ +KT Y
Sbjct: 934 RKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRT----KMPWKTCWRYLTSG 989
Query: 329 FFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYF-----------YTVLLFVTACLQ 377
FF I LM+FS ++LK + D W + Y V F C
Sbjct: 990 GFFLLI--LMIFS--KLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGA 1045
Query: 378 TLVLHQYFHICFVSGMRIKTAVIGA-------VYRKALVITNSARKSSTVGEIVNLMSVD 430
+ L C V+ + ++ + A + K ++ ++ +G I+N S D
Sbjct: 1046 GIFL------CLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSAD 1099
Query: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLN-LGPSVLAGVAVMVLMVPVNAVMAMKTKT 489
I+ L+ + LL L+ +G A +V ++P+ K
Sbjct: 1100 TN-------IIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKY 1152
Query: 490 YQVAH--MKSKDNRIKL-----MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKS 542
++VA ++ D+ +L +E G+ ++ + E FK ++L EL
Sbjct: 1153 FRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRML-----ELTDTNNI 1207
Query: 543 AYL--SAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
AYL SA + V T +L A + + + + V L L L N L
Sbjct: 1208 AYLFLSAANRWLEVRTDYLGACIVLTASIASISGS---SNSGLVGLGLLYALTIT-NYLN 1263
Query: 601 MVISSIVQASVSL---KRLRIFLSHEE------LEPDSIERRPVKDGGGTNSITVRNATF 651
V+ ++ V + K++ FL+ E ++P + ++G I + +
Sbjct: 1264 WVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEG----EIKIHDLCV 1319
Query: 652 TWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNLS 710
+ + P L + I G V + G+ G GKSSL A +D +G + I G+++S
Sbjct: 1320 RYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDIS 1378
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 480 bits (1236), Expect = e-135
Identities = 284/781 (36%), Positives = 435/781 (55%), Gaps = 60/781 (7%)
Query: 705 KGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRI 764
+G+NLSGGQKQR+SLARAVYS+ IYL DDPLSAVDAHVGKHIFE I K L+ KT +
Sbjct: 630 RGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI--KKTLRGKTVV 687
Query: 765 LVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQDAEE 821
LVTH + YL II++ GKI E G++ EL+ + G +A+ ++ A+++ QD +
Sbjct: 688 LVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAK 747
Query: 822 NGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAK 881
E ++E+ L T S S +G+ H T E
Sbjct: 748 IA---------EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE------- 780
Query: 882 KEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVS-ALASNYWLSLW 940
++ + G + VY Y++A G ++ IF F+ V + S +WLS W
Sbjct: 781 ----------EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYW 830
Query: 941 TDDPIVNGTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL------ 984
+ + + ++ G + + ++ V+G + + V GI
Sbjct: 831 LEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRK 890
Query: 985 ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIG 1044
AS LH L + + R PMSFF+ P G L+N F+ +L+ +D ++P + F+ VI
Sbjct: 891 ASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIA 950
Query: 1045 ACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVS 1104
+++ + +P ++ + +I F + + KRLE+ SRSP++SH +L G+S
Sbjct: 951 VLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLS 1010
Query: 1105 VIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRH 1164
I + + E FI Q D + + RW+A+RLE + N + L ALF
Sbjct: 1011 SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGIS 1070
Query: 1165 SLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQIQETA 1223
S ++V+ LQ+ + R+ E E AVER+ +Y + EAP ++ T+
Sbjct: 1071 STPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTS 1130
Query: 1224 PPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFR 1283
P WPQ G + F++Y ++YR++ VL IN+TI G E VGIVGRTG+GKSSL + LFR
Sbjct: 1131 CPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFR 1190
Query: 1284 INESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTS 1343
+ E G I+IDG++I IGL DLR K+++IPQDPVL SG++R NLDPF +++D+++W +
Sbjct: 1191 LVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDA 1250
Query: 1344 LELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDL 1403
LE L +S P KL + E G N SVG+RQL+C+ARA+LR +KI+++DEATA++D+
Sbjct: 1251 LERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDM 1310
Query: 1404 ETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFY 1463
ETD LIQ TIR F+ CTVL IAHR+ T+++ ++V+ G++ E+ P L ++ G +
Sbjct: 1311 ETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1370
Query: 1464 S 1464
+
Sbjct: 1371 A 1371
Score = 106 bits (265), Expect = 1e-22
Identities = 110/540 (20%), Positives = 220/540 (40%), Gaps = 86/540 (15%)
Query: 205 PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264
P P P +A S +T W+T L+++ R L+ + + L+ D S++ V L + W++E
Sbjct: 81 PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140
Query: 265 CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324
++ + V+ L++ Q+ +F L G
Sbjct: 141 VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172
Query: 325 FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384
F ++ I I+ ++++ + G LF++ C+++L
Sbjct: 173 FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223
Query: 385 FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444
+ I + +R + AV + K + + +S GE ++ + D + Y ++
Sbjct: 224 WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281
Query: 445 WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504
+++ + +G + + +L+ P+ M Q + D RI++
Sbjct: 282 LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341
Query: 505 MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564
+E+L IK++K+Y WE F + +R++E K+L+K + ++ + T F++
Sbjct: 342 TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITL----FIIPTVA 397
Query: 565 FAVYVTIDEN--NILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSH 622
AV+V I + L A AF LA N+LR + +P+ + + + ++ R + F
Sbjct: 398 TAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQ 457
Query: 623 EELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG------------------- 663
E + ++D + ++ AT +W ++ P +NG
Sbjct: 458 ES---PVFYVQTLQD--PSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRD 512
Query: 664 -----------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG 706
I + +G ++ V G G GKSSLLSA+L EM +EG V ++G
Sbjct: 513 ALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG 572
Score = 90.9 bits (224), Expect = 8e-18
Identities = 65/224 (29%), Positives = 105/224 (46%), Gaps = 18/224 (8%)
Query: 1251 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1310
L IN+ ++ G +G+ G TG+GKSSL + EG + + G
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
Query: 1311 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1370
+ +PQ + SG++R N+ Y L L + LP E E G N
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633
Query: 1371 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTIAHRL 1429
LS GQ+Q + LARA+ +I +LD+ +AVD + + I+ TV+ + H+L
Sbjct: 634 LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693
Query: 1430 NTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG----LFYSMAKDA 1469
+ ++I+L+ G+I E G S+L+Q++G L M K+A
Sbjct: 694 QYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA 737
Score = 48.1 bits (113), Expect = 6e-05
Identities = 34/131 (25%), Positives = 63/131 (48%), Gaps = 4/131 (3%)
Query: 684 KSSLLSALLAEMDKVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHV 743
++ L A+ K+ V G N S G++Q + +ARAV N+ I L D+ +++D
Sbjct: 1253 RTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMET 1312
Query: 744 GKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGA- 802
I + + + T +++ H ++ + D I+VM GK+ E + L + G+
Sbjct: 1313 DTLIQRTI---REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSL 1369
Query: 803 FAEFLRTYAST 813
FA + T S+
Sbjct: 1370 FAALMATATSS 1380
Score = 43.9 bits (102), Expect = 0.001
Identities = 66/337 (19%), Positives = 138/337 (40%), Gaps = 41/337 (12%)
Query: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVIL 453
+ TA+ ++ K S + +G ++N + D ++ L + + +++
Sbjct: 890 KASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVI 949
Query: 454 ALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNG 511
A+ L+ L P +L A+++++ + +M K + K +N R L + ILN
Sbjct: 950 AVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKA----IGVFKRLENYSRSPLFSHILNS 1005
Query: 512 IKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTI 571
++ L + + K + + + L + + L + + W+ A+ + I
Sbjct: 1006 LQGLS--SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWM-----------ALRLEI 1052
Query: 572 DENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIE 631
N + A FV+ F I P + M ++ ++Q + S + E + ++E
Sbjct: 1053 MTNLVTLAVALFVA---FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVE 1109
Query: 632 R-----------RPVKDGGGT--------NSITVRNATFTWARSDPPTLNGITFSIPEGA 672
R P+ G + I ++ + + P L+GI +I
Sbjct: 1110 RILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHE 1169
Query: 673 LVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNL 709
+V +VG+ G GKSSL AL ++ + G + I GV++
Sbjct: 1170 VVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDI 1206
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 480 bits (1236), Expect = e-135
Identities = 284/781 (36%), Positives = 435/781 (55%), Gaps = 60/781 (7%)
Query: 705 KGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRI 764
+G+NLSGGQKQR+SLARAVYS+ IYL DDPLSAVDAHVGKHIFE I K L+ KT +
Sbjct: 630 RGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI--KKTLRGKTVV 687
Query: 765 LVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQDAEE 821
LVTH + YL II++ GKI E G++ EL+ + G +A+ ++ A+++ QD +
Sbjct: 688 LVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAK 747
Query: 822 NGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAK 881
E ++E+ L T S S +G+ H T E
Sbjct: 748 IA---------EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE------- 780
Query: 882 KEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVS-ALASNYWLSLW 940
++ + G + VY Y++A G ++ IF F+ V + S +WLS W
Sbjct: 781 ----------EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYW 830
Query: 941 TDDPIVNGTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL------ 984
+ + + ++ G + + ++ V+G + + V GI
Sbjct: 831 LEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRK 890
Query: 985 ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIG 1044
AS LH L + + R PMSFF+ P G L+N F+ +L+ +D ++P + F+ VI
Sbjct: 891 ASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIA 950
Query: 1045 ACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVS 1104
+++ + +P ++ + +I F + + KRLE+ SRSP++SH +L G+S
Sbjct: 951 VLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLS 1010
Query: 1105 VIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRH 1164
I + + E FI Q D + + RW+A+RLE + N + L ALF
Sbjct: 1011 SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGIS 1070
Query: 1165 SLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQIQETA 1223
S ++V+ LQ+ + R+ E E AVER+ +Y + EAP ++ T+
Sbjct: 1071 STPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTS 1130
Query: 1224 PPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFR 1283
P WPQ G + F++Y ++YR++ VL IN+TI G E VGIVGRTG+GKSSL + LFR
Sbjct: 1131 CPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFR 1190
Query: 1284 INESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTS 1343
+ E G I+IDG++I IGL DLR K+++IPQDPVL SG++R NLDPF +++D+++W +
Sbjct: 1191 LVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDA 1250
Query: 1344 LELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDL 1403
LE L +S P KL + E G N SVG+RQL+C+ARA+LR +KI+++DEATA++D+
Sbjct: 1251 LERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDM 1310
Query: 1404 ETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFY 1463
ETD LIQ TIR F+ CTVL IAHR+ T+++ ++V+ G++ E+ P L ++ G +
Sbjct: 1311 ETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1370
Query: 1464 S 1464
+
Sbjct: 1371 A 1371
Score = 106 bits (265), Expect = 1e-22
Identities = 110/540 (20%), Positives = 220/540 (40%), Gaps = 86/540 (15%)
Query: 205 PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264
P P P +A S +T W+T L+++ R L+ + + L+ D S++ V L + W++E
Sbjct: 81 PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140
Query: 265 CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324
++ + V+ L++ Q+ +F L G
Sbjct: 141 VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172
Query: 325 FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384
F ++ I I+ ++++ + G LF++ C+++L
Sbjct: 173 FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223
Query: 385 FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444
+ I + +R + AV + K + + +S GE ++ + D + Y ++
Sbjct: 224 WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281
Query: 445 WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504
+++ + +G + + +L+ P+ M Q + D RI++
Sbjct: 282 LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341
Query: 505 MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564
+E+L IK++K+Y WE F + +R++E K+L+K + ++ + T F++
Sbjct: 342 TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITL----FIIPTVA 397
Query: 565 FAVYVTIDEN--NILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSH 622
AV+V I + L A AF LA N+LR + +P+ + + + ++ R + F
Sbjct: 398 TAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQ 457
Query: 623 EELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG------------------- 663
E + ++D + ++ AT +W ++ P +NG
Sbjct: 458 ES---PVFYVQTLQD--PSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRD 512
Query: 664 -----------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG 706
I + +G ++ V G G GKSSLLSA+L EM +EG V ++G
Sbjct: 513 ALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG 572
Score = 90.9 bits (224), Expect = 8e-18
Identities = 65/224 (29%), Positives = 105/224 (46%), Gaps = 18/224 (8%)
Query: 1251 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1310
L IN+ ++ G +G+ G TG+GKSSL + EG + + G
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
Query: 1311 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1370
+ +PQ + SG++R N+ Y L L + LP E E G N
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633
Query: 1371 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTIAHRL 1429
LS GQ+Q + LARA+ +I +LD+ +AVD + + I+ TV+ + H+L
Sbjct: 634 LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693
Query: 1430 NTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG----LFYSMAKDA 1469
+ ++I+L+ G+I E G S+L+Q++G L M K+A
Sbjct: 694 QYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA 737
Score = 48.1 bits (113), Expect = 6e-05
Identities = 34/131 (25%), Positives = 63/131 (48%), Gaps = 4/131 (3%)
Query: 684 KSSLLSALLAEMDKVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHV 743
++ L A+ K+ V G N S G++Q + +ARAV N+ I L D+ +++D
Sbjct: 1253 RTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMET 1312
Query: 744 GKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGA- 802
I + + + T +++ H ++ + D I+VM GK+ E + L + G+
Sbjct: 1313 DTLIQRTI---REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSL 1369
Query: 803 FAEFLRTYAST 813
FA + T S+
Sbjct: 1370 FAALMATATSS 1380
Score = 43.9 bits (102), Expect = 0.001
Identities = 66/337 (19%), Positives = 138/337 (40%), Gaps = 41/337 (12%)
Query: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVIL 453
+ TA+ ++ K S + +G ++N + D ++ L + + +++
Sbjct: 890 KASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVI 949
Query: 454 ALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNG 511
A+ L+ L P +L A+++++ + +M K + K +N R L + ILN
Sbjct: 950 AVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKA----IGVFKRLENYSRSPLFSHILNS 1005
Query: 512 IKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTI 571
++ L + + K + + + L + + L + + W+ A+ + I
Sbjct: 1006 LQGLS--SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWM-----------ALRLEI 1052
Query: 572 DENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIE 631
N + A FV+ F I P + M ++ ++Q + S + E + ++E
Sbjct: 1053 MTNLVTLAVALFVA---FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVE 1109
Query: 632 R-----------RPVKDGGGT--------NSITVRNATFTWARSDPPTLNGITFSIPEGA 672
R P+ G + I ++ + + P L+GI +I
Sbjct: 1110 RILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHE 1169
Query: 673 LVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNL 709
+V +VG+ G GKSSL AL ++ + G + I GV++
Sbjct: 1170 VVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDI 1206
>gi|21729876 ATP-binding cassette, sub-family C, member 11 isoform b
[Homo sapiens]
Length = 1344
Score = 423 bits (1087), Expect = e-118
Identities = 266/781 (34%), Positives = 410/781 (52%), Gaps = 98/781 (12%)
Query: 705 KGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRI 764
+G+NLSGGQKQR+SLARAVYS+ IYL DDPLSAVDAHVGKHIFE I K L+ KT +
Sbjct: 630 RGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI--KKTLRGKTVV 687
Query: 765 LVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQDAEE 821
LVTH + YL II++ GKI E G++ EL+ + G +A+ ++ A+++ QD +
Sbjct: 688 LVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAK 747
Query: 822 NGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAK 881
E ++E+ L T S S +G+ H T E
Sbjct: 748 IA---------EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE------- 780
Query: 882 KEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVS-ALASNYWLSLW 940
++ + G + VY Y++A G ++ IF F+ V + S +WLS W
Sbjct: 781 ----------EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYW 830
Query: 941 TDDPIVNGTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL------ 984
+ + + ++ G + + ++ V+G + + V GI
Sbjct: 831 LEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRK 890
Query: 985 ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIG 1044
AS LH L + + R PMSFF+ P G L+N F+ +L+ +D ++P + F+ VI
Sbjct: 891 ASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIA 950
Query: 1045 ACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVS 1104
+++ + +P ++ + +I F + + KRLE+ SRSP++SH +L G+S
Sbjct: 951 VLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLS 1010
Query: 1105 VIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRH 1164
I + + E FI Q D + + RW+A+RLE + N + L ALF
Sbjct: 1011 SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGIS 1070
Query: 1165 SLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQIQETA 1223
S ++V+ LQ+ + R+ E E AVER+ +Y + EAP ++ T+
Sbjct: 1071 STPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTS 1130
Query: 1224 PPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFR 1283
P WPQ G + F++Y ++YR++ VL IN+TI G E VGIVGRTG+GKSSL + LFR
Sbjct: 1131 CPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFR 1190
Query: 1284 INESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTS 1343
+ E G I+IDG++I IGL DLR K+++IPQDPVL SG++R NLDPF +++D+++W +
Sbjct: 1191 LVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDA 1250
Query: 1344 LELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDL 1403
LE R L K I+++DEATA++D+
Sbjct: 1251 LE-------------------------------------RTFLTKA-IILIDEATASIDM 1272
Query: 1404 ETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFY 1463
ETD LIQ TIR F+ CTVL IAHR+ T+++ ++V+ G++ E+ P L ++ G +
Sbjct: 1273 ETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLF 1332
Query: 1464 S 1464
+
Sbjct: 1333 A 1333
Score = 106 bits (265), Expect = 1e-22
Identities = 110/540 (20%), Positives = 220/540 (40%), Gaps = 86/540 (15%)
Query: 205 PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264
P P P +A S +T W+T L+++ R L+ + + L+ D S++ V L + W++E
Sbjct: 81 PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140
Query: 265 CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324
++ + V+ L++ Q+ +F L G
Sbjct: 141 VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172
Query: 325 FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384
F ++ I I+ ++++ + G LF++ C+++L
Sbjct: 173 FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223
Query: 385 FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444
+ I + +R + AV + K + + +S GE ++ + D + Y ++
Sbjct: 224 WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281
Query: 445 WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504
+++ + +G + + +L+ P+ M Q + D RI++
Sbjct: 282 LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341
Query: 505 MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564
+E+L IK++K+Y WE F + +R++E K+L+K + ++ + T F++
Sbjct: 342 TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITL----FIIPTVA 397
Query: 565 FAVYVTIDEN--NILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSH 622
AV+V I + L A AF LA N+LR + +P+ + + + ++ R + F
Sbjct: 398 TAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQ 457
Query: 623 EELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG------------------- 663
E + ++D + ++ AT +W ++ P +NG
Sbjct: 458 ES---PVFYVQTLQD--PSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRD 512
Query: 664 -----------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG 706
I + +G ++ V G G GKSSLLSA+L EM +EG V ++G
Sbjct: 513 ALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG 572
Score = 90.9 bits (224), Expect = 8e-18
Identities = 65/224 (29%), Positives = 105/224 (46%), Gaps = 18/224 (8%)
Query: 1251 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1310
L IN+ ++ G +G+ G TG+GKSSL + EG + + G
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
Query: 1311 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1370
+ +PQ + SG++R N+ Y L L + LP E E G N
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633
Query: 1371 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTIAHRL 1429
LS GQ+Q + LARA+ +I +LD+ +AVD + + I+ TV+ + H+L
Sbjct: 634 LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693
Query: 1430 NTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG----LFYSMAKDA 1469
+ ++I+L+ G+I E G S+L+Q++G L M K+A
Sbjct: 694 QYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA 737
Score = 50.8 bits (120), Expect = 9e-06
Identities = 92/476 (19%), Positives = 186/476 (39%), Gaps = 79/476 (16%)
Query: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVIL 453
+ TA+ ++ K S + +G ++N + D ++ L + + +++
Sbjct: 890 KASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVI 949
Query: 454 ALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNG 511
A+ L+ L P +L A+++++ + +M K + K +N R L + ILN
Sbjct: 950 AVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKA----IGVFKRLENYSRSPLFSHILNS 1005
Query: 512 IKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTI 571
++ L + + K + + + L + + L + + W+ A+ + I
Sbjct: 1006 LQGLS--SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWM-----------ALRLEI 1052
Query: 572 DENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIE 631
N + A FV+ F I P + M ++ ++Q + S + E + ++E
Sbjct: 1053 MTNLVTLAVALFVA---FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVE 1109
Query: 632 R-----------RPVKDGGGT--------NSITVRNATFTWARSDPPTLNGITFSIPEGA 672
R P+ G + I ++ + + P L+GI +I
Sbjct: 1110 RILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHE 1169
Query: 673 LVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVN------------LSGGQKQRVSLA 720
+V +VG+ G GKSSL AL ++ + G + I GV+ LS + V L+
Sbjct: 1170 VVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLS 1229
Query: 721 RAVYSNAD----------------------IYLFDDPLSAVDAHVGKHIFENVIGPKGML 758
+ N D I L D+ +++D I + +
Sbjct: 1230 GTIRFNLDPFDRHTDQQIWDALERTFLTKAIILIDEATASIDMETDTLIQRTI---REAF 1286
Query: 759 KNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGA-FAEFLRTYAST 813
+ T +++ H ++ + D I+VM GK+ E + L + G+ FA + T S+
Sbjct: 1287 QGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSS 1342
>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
[Homo sapiens]
Length = 859
Score = 322 bits (825), Expect = 2e-87
Identities = 247/914 (27%), Positives = 422/914 (46%), Gaps = 159/914 (17%)
Query: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
P++ E P P A+ SR+ FWW+ L G+++ LE D++S+ ED S+ +
Sbjct: 3 PVYQEV----KPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGE 58
Query: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
L W KE + K PSL +
Sbjct: 59 ELQGFWDKEVLRAENDAQK------------------------------------PSLTR 82
Query: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVN-----DTKAPDWQGYFYTVLL 370
+ K + +L+ F I + P L +I + D+ A + + TVL
Sbjct: 83 AIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLT 142
Query: 371 FVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVD 430
F T L ++ H YF+ +GMR++ A+ +YRKAL ++N A +T G+IVNL+S D
Sbjct: 143 FCTLIL-AILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSND 201
Query: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
+F + +++ +W+ PLQ I LLW+ +G S LAG+AV+++++P+ + +
Sbjct: 202 VNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSL 261
Query: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
+ D RI+ MNE++ GI+++K+YAWE +F + + +R++E+ + +S+ L +
Sbjct: 262 RSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNL 321
Query: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNI-LPMVISSIVQA 609
++ ++ TF YV + +++ A FV++ L+ +R + + P I + +A
Sbjct: 322 ASFFSASKIIVFVTFTTYVLL--GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA 379
Query: 610 SVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWAR-SDPPTLNGITFSI 668
VS++R++ FL +E+ +R G + V++ T W + S+ PTL G++F++
Sbjct: 380 IVSIRRIQTFLLLDEIS----QRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTV 435
Query: 669 PEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG-----------------VNLSG 711
G L+AVVG VG GKSSLLSA+L E+ G V++ G N+
Sbjct: 436 RPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILF 495
Query: 712 GQK----QRVSLARAVYSNADIYLFDD--------------------------------- 734
G+K + + +A D+ L +D
Sbjct: 496 GKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADI 555
Query: 735 -----PLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISE 789
PLSAVDA V +H+FE I +L K ILVTH + YL I+++ GK+ +
Sbjct: 556 YLLDDPLSAVDAEVSRHLFELCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQ 613
Query: 790 MGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK 849
G+Y E L F L+ + +++E+ V G + N
Sbjct: 614 KGTYTEFLKSGIDFGSLLK-----KDNEESEQPPVPG-------TPTLRN---------- 651
Query: 850 QLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMK 909
R S SS +S SR L+ + E + + G+V Y +Y +
Sbjct: 652 ---RTFSESSVWSQQSSRPSLKDGALESQDT--ENVPVTLSEENRSEGKVGFQAYKNYFR 706
Query: 910 AIGLFISFLSIFLFMCN---HVSALASNYWLSLWTD-----DPIVNGTQEHTKVRLSVYG 961
A +I F IFL + N V+ + ++WLS W + + VNG T+ +L +
Sbjct: 707 AGAHWIVF--IFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTE-KLDLNW 763
Query: 962 ALGISQGIAV----FGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVN 1015
LGI G+ V FG + ++ + +L +S+ LH + SIL++P+ FF+R P G ++N
Sbjct: 764 YLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILN 823
Query: 1016 RFSKELDTVDSMIP 1029
RFSK++ +D ++P
Sbjct: 824 RFSKDIGHLDDLLP 837
Score = 83.2 bits (204), Expect = 2e-15
Identities = 106/489 (21%), Positives = 204/489 (41%), Gaps = 32/489 (6%)
Query: 989 LHVDLLHSILRSPMSFFE----RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIG 1044
L V + H I R + +T +G +VN S +++ D + + ++ G L I
Sbjct: 166 LRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPL-QAIA 224
Query: 1045 ACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVS 1104
++ + I+ + + +I +Q + L+ + NE + G+
Sbjct: 225 VTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIR 284
Query: 1105 VIRAFEEQERFIHQ-SDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISR 1163
+I+ + ++ F + ++L+ E K S + LA IV V+
Sbjct: 285 IIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSA-SKIIVFVTFTTYVLLG 343
Query: 1164 HSLSAGLVGLSVSY----SLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQI 1219
++A V ++V+ L VT + + SE IV++ R++ + ++ + Q
Sbjct: 344 SVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA---IVSIRRIQTFLLLDEIS--QR 398
Query: 1220 QETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTL 1279
P V +F + + E L+ ++ T+ GE + +VG GAGKSSL
Sbjct: 399 NRQLPSDGKKMVHVQDFTAFWDKASETP--TLQGLSFTVRPGELLAVVGPVGAGKSSLLS 456
Query: 1280 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEE 1339
+ + G + + G +I + Q P +FSG+LR N+ +Y E
Sbjct: 457 AVLGELAPSHGLVSVHG-------------RIAYVSQQPWVFSGTLRSNILFGKKYEKER 503
Query: 1340 VWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATA 1399
++ LK + L D + G LS GQ+ V LARA+ + I +LD+ +
Sbjct: 504 YEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLS 563
Query: 1400 AVDLETD-DLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1458
AVD E L + I + + + H+L + +++++L G++ + G ++ L+
Sbjct: 564 AVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKS 623
Query: 1459 RGLFYSMAK 1467
F S+ K
Sbjct: 624 GIDFGSLLK 632
>gi|90421313 cystic fibrosis transmembrane conductance regulator [Homo
sapiens]
Length = 1480
Score = 276 bits (706), Expect = 1e-73
Identities = 159/524 (30%), Positives = 287/524 (54%), Gaps = 24/524 (4%)
Query: 960 YGALGISQGIAVFGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRF 1017
Y +G++ + G+ + + L S+ LH +LHS+L++PMS +G ++NRF
Sbjct: 917 YIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRF 976
Query: 1018 SKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVAS 1077
SK++ +D ++P I F+ L VIGA V+ + P + P+ + + ++ +++ +
Sbjct: 977 SKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQT 1036
Query: 1078 SRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVAN 1137
S+QLK+LES RSP+++H +L G+ +RAF Q F ++ + ++ +
Sbjct: 1037 SQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTL 1096
Query: 1138 RWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMET 1197
RW +R+E + I A F I G VG+ ++ ++ + + L W V S ++++
Sbjct: 1097 RWFQMRIEMIF-VIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDS 1155
Query: 1198 NIVAVERLKEYSETEKEAPWQIQETAPPSS-------------------WPQVGRVEFRN 1238
+ +V R+ ++ + E + T P + WP G++ ++
Sbjct: 1156 LMRSVSRVFKFIDMPTEGK-PTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKD 1214
Query: 1239 YCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGIN 1298
+Y E + +L +I+ +I+ G++VG++GRTG+GKS+L R+ + EGEI IDG++
Sbjct: 1215 LTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EGEIQIDGVS 1273
Query: 1299 IAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPD 1358
I L R +IPQ +FSG+ R NLDP+ Q+SD+E+W + L+ + P
Sbjct: 1274 WDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPG 1333
Query: 1359 KLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFE 1418
KLD +GG LS G +QL+CLAR++L K KIL+LDE +A +D T +I+ T++ F
Sbjct: 1334 KLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFA 1393
Query: 1419 DCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLF 1462
DCTV+ HR+ +++ + +V+++ ++++Y + LL +R LF
Sbjct: 1394 DCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLF 1437
Score = 150 bits (380), Expect = 7e-36
Identities = 146/709 (20%), Positives = 274/709 (38%), Gaps = 145/709 (20%)
Query: 209 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKT 268
P AS +S++ F W ++ +GYRQ LE SD++ + D+++ + L + W +E A
Sbjct: 5 PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASK 64
Query: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328
+ NP L L + F F+
Sbjct: 65 K----------------------------------------NPKLINALRRCFFWRFMFY 84
Query: 329 FFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHI 387
F + ++ P +L +++ + D K + + L + ++TL+LH
Sbjct: 85 GIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFG 144
Query: 388 CFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSA 447
GM+++ A+ +Y+K L +++ ++G++V+L+S + +F + + +W A
Sbjct: 145 LHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIA 204
Query: 448 PLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNE 507
PLQV L + L+W L S G+ ++++ A + Y+ R+ + +E
Sbjct: 205 PLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSE 264
Query: 508 ILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAV 567
++ I+ +K Y WE A + + +RQ ELK+ +K+AY+ + + + F V +
Sbjct: 265 MIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLP 324
Query: 568 YVTIDENNILDAQTAFVSLALFNILRFPL-NILPMVISSIVQASVSLKRLRIFLSHEELE 626
Y I + + F +++ +LR + P + + + ++ +++ FL +E
Sbjct: 325 YALIKG---IILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEY- 380
Query: 627 PDSIERRPVKDGGGTNSITVRNATFTWARS------------------------------ 656
+ ++ T + + N T W
Sbjct: 381 ------KTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFS 434
Query: 657 --DPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG-------- 706
P L I F I G L+AV G G GK+SLL ++ E++ EG + G
Sbjct: 435 LLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQF 494
Query: 707 -------------VNLSGGQKQRVSLARAVYSNADIYLF--------------------- 732
+S + + S+ +A DI F
Sbjct: 495 SWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRA 554
Query: 733 ----------DDPLSAVDAHVG-------KHIFENVIGPKGMLKNKTRILVTHSMSYLPQ 775
D L +D+ G K IFE+ + ++ NKTRILVT M +L +
Sbjct: 555 RISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCK--LMANKTRILVTSKMEHLKK 612
Query: 776 VDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGV 824
D I+++ G G++ EL F+ L S +Q N +
Sbjct: 613 ADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSI 661
Score = 72.4 bits (176), Expect = 3e-12
Identities = 51/207 (24%), Positives = 100/207 (48%), Gaps = 14/207 (6%)
Query: 1250 VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRF 1309
VL+ IN I G+ + + G TGAGK+SL + + E +EG+I G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
Query: 1310 KITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGE 1369
+I+ Q + G+++ N+ Y + + ++ L++ +S +K + EGG
Sbjct: 487 RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGI 546
Query: 1370 NLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETD-DLIQSTIRTQFEDCTVLTIAHR 1428
LS GQR + LARA+ + + +LD +D+ T+ ++ +S + + T + + +
Sbjct: 547 TLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSK 606
Query: 1429 LNTIMDYTRVIVLDKGEIQEYGAPSDL 1455
+ + ++++L +G YG S+L
Sbjct: 607 MEHLKKADKILILHEGSSYFYGTFSEL 633
Score = 46.2 bits (108), Expect = 2e-04
Identities = 28/84 (33%), Positives = 46/84 (54%), Gaps = 3/84 (3%)
Query: 625 LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGK 684
+E +++ + GG +TV++ T + L I+FSI G V ++G+ G GK
Sbjct: 1193 IENSHVKKDDIWPSGG--QMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGK 1250
Query: 685 SSLLSALLAEMDKVEGHVAIKGVN 708
S+LLSA L ++ EG + I GV+
Sbjct: 1251 STLLSAFLRLLN-TEGEIQIDGVS 1273
Score = 40.8 bits (94), Expect = 0.010
Identities = 31/100 (31%), Positives = 47/100 (47%), Gaps = 3/100 (3%)
Query: 706 GVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRIL 765
G LS G KQ + LAR+V S A I L D+P + +D V I + K + T IL
Sbjct: 1343 GCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIRRTL--KQAFADCTVIL 1399
Query: 766 VTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAE 805
H + + + +V+ K+ + S Q+LL F +
Sbjct: 1400 CEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQ 1439
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 198 bits (503), Expect = 4e-50
Identities = 193/796 (24%), Positives = 358/796 (44%), Gaps = 71/796 (8%)
Query: 697 KVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKG 756
K + V +G LSGGQKQR+++ARA+ N I L D+ SA+D + +
Sbjct: 519 KFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVV---QVALDK 575
Query: 757 MLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYAS---T 813
K +T I++ H +S + DVI G I E G++ EL+ G + + + +
Sbjct: 576 ARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEV 635
Query: 814 EQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTA 873
E E A+E+ E +E M DS ++++ + S ST
Sbjct: 636 ELENAADESK--------SEIDALE--MSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTK 685
Query: 874 ELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALAS 933
E W++M+ + + W Y +G+F + ++ L A+
Sbjct: 686 EALDESIPPVSFWRIMKLNLTE---------WPYF-VVGVFCAIINGGL---QPAFAIIF 732
Query: 934 NYWLSLWT--DDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHV 991
+ + ++T DDP ++++ + ++ ALGI I F G + ++ L
Sbjct: 733 SKIIGVFTRIDDPETK--RQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRY 790
Query: 992 DLLHSILRSPMSFFE--RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVI 1049
+ S+LR +S+F+ + +G L R + + V I + + ++ N+ I+
Sbjct: 791 MVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIIS 850
Query: 1050 LL----ATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSV 1105
+ T + I+P + + V + S + LK + + S + E +
Sbjct: 851 FIYGWQLTLLLLAIVPIIAIAG--VVEMKMLSGQALKDKKELEGSGKIA--TEAIENFRT 906
Query: 1106 IRAFEEQERFIHQ--SDLKV---DENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAV 1160
+ + ++++F H L+V + +KA+ I + A+ C A L A
Sbjct: 907 VVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAH 966
Query: 1161 ISRHSLSAGLVGLSVSYSL----QVTTYLNWLVRMSSEMETNIVAVER---LKEYSETEK 1213
LV +V + QV+++ + I+ +E+ + YS TE
Sbjct: 967 KLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYS-TEG 1025
Query: 1214 EAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGA 1272
P ++ G V F Y D VL+ +++ + G+ + +VG +G
Sbjct: 1026 LMPNTLE-----------GNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGC 1074
Query: 1273 GKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL--- 1329
GKS++ L R + G++++DG I ++ + LR + I+ Q+P+LF S+ N+
Sbjct: 1075 GKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYG 1134
Query: 1330 DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKT 1389
D S EE+ + + A++ F+ +LP+K + + G LS GQ+Q + +ARAL+R+
Sbjct: 1135 DNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQP 1194
Query: 1390 KILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEY 1449
IL+LDEAT+A+D E++ ++Q + E T + IAHRL+TI + ++V G ++E+
Sbjct: 1195 HILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEH 1254
Query: 1450 GAPSDLLQQRGLFYSM 1465
G LL Q+G+++SM
Sbjct: 1255 GTHQQLLAQKGIYFSM 1270
Score = 155 bits (392), Expect = 3e-37
Identities = 138/522 (26%), Positives = 249/522 (47%), Gaps = 36/522 (6%)
Query: 964 GISQGIAVFGYSMAVSIGGILASRCLHV---DLLHSILRSPMSFFERTPSGNLVNRFSKE 1020
GI G+ V Y + VS + A R +H H+I+R + +F+ G L R + +
Sbjct: 120 GIGAGVLVAAY-IQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDD 178
Query: 1021 LDTVDSMIPEVIKMFMGSLFNVIGACIVILL----ATPIAAIIIPPLGLIYFFVQRFYVA 1076
+ ++ I + I MF S+ IV T + I P LGL + +
Sbjct: 179 VSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAK--IL 236
Query: 1077 SSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQK-AYYPSIV 1135
SS K L + +++ + E L + + AF Q++ + + + ++E ++ +I
Sbjct: 237 SSFTDKELLAYAKAGAVA--EEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAIT 294
Query: 1136 ANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVG-------LSVSYSLQVTTYLNWL 1188
AN +G +L A +A+ + + L G L+V +S+ + +
Sbjct: 295 AN-------ISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQ 347
Query: 1189 VRMSSEMETNI--VAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRY--R 1244
S E N A E K + P + G +EFRN Y R
Sbjct: 348 ASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNI---KGNLEFRNVHFSYPSR 404
Query: 1245 EDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGL 1304
+++ +L+ +N+ + G+ V +VG +G GKS+ + R+ + EG + +DG +I I +
Sbjct: 405 KEVK-ILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINV 463
Query: 1305 HDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYSDEEVWTSLELAHLKDFVSALPDKLDHE 1363
LR I ++ Q+PVLF+ ++ N+ + +E+ +++ A+ DF+ LP K D
Sbjct: 464 RFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTL 523
Query: 1364 CAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVL 1423
E G LS GQ+Q + +ARAL+R KIL+LDEAT+A+D E++ ++Q + + T +
Sbjct: 524 VGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTI 583
Query: 1424 TIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1465
IAHRL+T+ + + D G I E G +L++++G+++ +
Sbjct: 584 VIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKL 625
Score = 76.3 bits (186), Expect = 2e-13
Identities = 43/138 (31%), Positives = 76/138 (55%), Gaps = 4/138 (2%)
Query: 680 VGCGKSSLLSALLAEM-DKVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSA 738
V K + + A + + +K V KG LSGGQKQR+++ARA+ I L D+ SA
Sbjct: 1146 VRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSA 1205
Query: 739 VDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLA 798
+D K + E + + + +T I++ H +S + D+I+V G++ E G++Q+LLA
Sbjct: 1206 LDTESEKVVQEALDKAR---EGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLA 1262
Query: 799 RDGAFAEFLRTYASTEQE 816
+ G + + A T+++
Sbjct: 1263 QKGIYFSMVSVQAGTKRQ 1280
Score = 44.3 bits (103), Expect = 9e-04
Identities = 72/326 (22%), Positives = 125/326 (38%), Gaps = 41/326 (12%)
Query: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSV-LAGVAVMVLMVPV 479
G I + ++V Q +L T I + + Q L LL L + P + +AGV M ++
Sbjct: 827 GAIGSRLAVITQNIANLGTGIIISFIYGWQ----LTLLLLAIVPIIAIAGVVEMKML--- 879
Query: 480 NAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELK-V 538
+ A+K K K + K+ E + + + E F+ Q +
Sbjct: 880 -SGQALKDK-------KELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNS 931
Query: 539 LKKSAYLSAVGTFTWVCTPFLVALC-TFAVYVTIDENNILDAQTAFVSLALFNILRFPLN 597
L+K+ +FT F A C F Y+ + + S +F
Sbjct: 932 LRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGA------ 985
Query: 598 ILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTN---------SITVRN 648
M + + + + +I +H + IE+ P+ D T ++T
Sbjct: 986 ---MAVGQVSSFAPDYAKAKISAAHIIM---IIEKTPLIDSYSTEGLMPNTLEGNVTFGE 1039
Query: 649 ATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGV 707
F + R D P L G++ + +G +A+VG GCGKS+++ L D + G V + G
Sbjct: 1040 VVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGK 1099
Query: 708 NLSGGQKQRVSLARAVYSNADIYLFD 733
+ Q + + S I LFD
Sbjct: 1100 EIKRLNVQWLRAHLGIVSQEPI-LFD 1124
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 189 bits (480), Expect = 2e-47
Identities = 202/800 (25%), Positives = 354/800 (44%), Gaps = 82/800 (10%)
Query: 706 GVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRIL 765
G +SGGQKQRV++ARA+ N I L D SA+D + + + + V+ + T I
Sbjct: 556 GGQMSGGQKQRVAIARALIRNPKILLLDMATSALD-NESEAMVQEVLSK--IQHGHTIIS 612
Query: 766 VTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVT 825
V H +S + D II G E G+++ELL R G + F ++ Q E +
Sbjct: 613 VAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVY--FTLVTLQSQGNQALNEEDIK 670
Query: 826 GVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISR----HHNSTAELQKAEAK 881
+ A+ G DS ++++ S SY H ST E E +
Sbjct: 671 DATEDDMLARTFSRGSY-QDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYE----EDR 725
Query: 882 KEETWKLME-ADKAQTGQV-KLSV-YWDYMK--AIGLFIS--FLSIFLFMCNHVSALASN 934
K++ + E + A ++ K S W YM ++G ++ ++ F+ + + S
Sbjct: 726 KDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFS- 784
Query: 935 YWLSLWTDDPIVNGTQEHTKVR--LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVD 992
I + ++ +++ ++ A+G F A + G L ++ L
Sbjct: 785 ----------IPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKF 834
Query: 993 LLHSILRSPMSFFE--RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVIL 1050
++L +++F+ R G L R + + V I M + S NV A I+
Sbjct: 835 GFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAF 894
Query: 1051 LATPIAAIII----PPLGLIYFFVQRFYVA-SSRQLKRLESVSRSPVYSHFNETLLGVSV 1105
+ +++I P L L R +SR + LE V + NE L +
Sbjct: 895 SFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQIT-----NEALSNIRT 949
Query: 1106 IRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECV----------------GN 1149
+ ++ RFI + ++++ K + +C+ N
Sbjct: 950 VAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISN 1009
Query: 1150 CIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYS 1209
+ F+ +F VIS LSA +G + SY+ S + I A + +
Sbjct: 1010 EGLHFSYVFRVISAVVLSATALGRAFSYT-------------PSYAKAKISAA---RFFQ 1053
Query: 1210 ETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVG 1268
+++ P + TA G+++F + Y D VL ++V+I+ G+ + VG
Sbjct: 1054 LLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVG 1113
Query: 1269 RTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMN 1328
+G GKS+ L R + +G+++IDG + K+ + LR I I+ Q+PVLF+ S+ N
Sbjct: 1114 SSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDN 1173
Query: 1329 L---DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARAL 1385
+ D + E V + + A L DFV +LP+K + G LS G++Q + +ARA+
Sbjct: 1174 IKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAI 1233
Query: 1386 LRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGE 1445
+R KIL+LDEAT+A+D E++ +Q + E T + IAHRL+TI + + V+ +G
Sbjct: 1234 VRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGV 1293
Query: 1446 IQEYGAPSDLLQQRGLFYSM 1465
+ E G +L+ Q+G +Y +
Sbjct: 1294 VIEKGTHEELMAQKGAYYKL 1313
Score = 139 bits (350), Expect = 2e-32
Identities = 135/555 (24%), Positives = 255/555 (45%), Gaps = 40/555 (7%)
Query: 936 WLSLWTDDPIVNGTQ------EHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCL 989
W + + + NGT+ E ++ + Y A GI+ + + GY + + I A+R +
Sbjct: 114 WTNSSLNQNMTNGTRCGLLNIESEMIKFASYYA-GIAVAVLITGY-IQICFWVIAAARQI 171
Query: 990 HVD---LLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVI-GA 1045
I+R + +F+ G L RFS +++ ++ I + + +F+ + + I G
Sbjct: 172 QKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGF 231
Query: 1046 CIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLK-RLESVSRSPVYSHFNETLLGVS 1104
+ + +II LI ++ S+ L++ +++ V + +E + +
Sbjct: 232 LLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVA--DEVISSMR 289
Query: 1105 VIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGN-------CIVL--FA 1155
+ AF ++R + + + + + A RW +R V C++ +A
Sbjct: 290 TVAAFGGEKREVERYEKNL----------VFAQRW-GIRKGIVMGFFTGFVWCLIFLCYA 338
Query: 1156 ALFAVISRHSLSAG--LVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEK 1213
F S L G G V L V L S +E ET
Sbjct: 339 LAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETID 398
Query: 1214 EAPWQIQETAPPSSWPQV-GRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTG 1271
P + ++ G +EF N Y + +L +N+ I GE +VG +G
Sbjct: 399 RKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSG 458
Query: 1272 AGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDP 1331
AGKS+ + R + EG + +DG +I + + LR +I I+ Q+PVLFS ++ N+
Sbjct: 459 AGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRY 518
Query: 1332 FSQYSD-EEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTK 1390
+ + E++ + + A+ +F+ LP + D EGG +S GQ+Q V +ARAL+R K
Sbjct: 519 GREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPK 578
Query: 1391 ILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYG 1450
IL+LD AT+A+D E++ ++Q + T++++AHRL+T+ +I + G E G
Sbjct: 579 ILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERG 638
Query: 1451 APSDLLQQRGLFYSM 1465
+LL+++G+++++
Sbjct: 639 THEELLERKGVYFTL 653
Score = 70.9 bits (172), Expect = 9e-12
Identities = 43/145 (29%), Positives = 79/145 (54%), Gaps = 8/145 (5%)
Query: 665 TFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNLSGGQKQRVSLARAVY 724
T IP ++A Q + L +++ +K E +V +G LS G+KQR+++ARA+
Sbjct: 1180 TKEIPMERVIAAAKQ-----AQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIV 1234
Query: 725 SNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSG 784
+ I L D+ SA+D K + + + +T I++ H +S + D+I VM+
Sbjct: 1235 RDPKILLLDEATSALDTESEKTV---QVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQ 1291
Query: 785 GKISEMGSYQELLARDGAFAEFLRT 809
G + E G+++EL+A+ GA+ + + T
Sbjct: 1292 GVVIEKGTHEELMAQKGAYYKLVTT 1316
Score = 42.0 bits (97), Expect = 0.004
Identities = 24/57 (42%), Positives = 32/57 (56%), Gaps = 1/57 (1%)
Query: 651 FTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG 706
FT+ +R D LNG++ SI G +A VG GCGKS+ + L D +G V I G
Sbjct: 1085 FTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDG 1141
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 182 bits (462), Expect = 2e-45
Identities = 182/783 (23%), Positives = 336/783 (42%), Gaps = 48/783 (6%)
Query: 697 KVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKG 756
K + V +G LSGGQKQR+++ARA+ N I L D+ SA+D + + +
Sbjct: 521 KFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAR- 579
Query: 757 MLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQE 816
+ +T I++ H +S + DVI G I E GS+ EL+ ++G + + + S Q
Sbjct: 580 --EGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQI 637
Query: 817 QDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQ 876
Q +EE + + A L S K L+ S + +
Sbjct: 638 Q-SEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVE--------TDGL 688
Query: 877 KAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYW 936
+A K+++ +K + W Y +G + + L S + S
Sbjct: 689 EANVPPVSFLKVLKLNKTE---------WPYF-VVGTVCAIANGGLQPA--FSVIFSEII 736
Query: 937 LSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHS 996
D V Q+ + ++ LGI F G + +R L +
Sbjct: 737 AIFGPGDDAVK--QQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKA 794
Query: 997 ILRSPMSFFE--RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILL--- 1051
+LR MS+F+ + +G L R + + V + + ++ N+ I+ +
Sbjct: 795 MLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGW 854
Query: 1052 -ATPIAAIIIPPLGLIYFFVQRFYVASS-RQLKRLESVSRSPVYSHFN-ETLLGVSVIRA 1108
T + ++P + + + ++ R K LE+ + + N T++ ++ R
Sbjct: 855 QLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERK 914
Query: 1109 FEEQ--ERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSL 1166
FE E+ V QKA+ I + A C A L +++ H
Sbjct: 915 FESMYVEKLYGPYRNSV---QKAHIYGITFSISQAFMYFSYAGCFRFGAYL--IVNGHMR 969
Query: 1167 SAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPS 1226
++ L S + L + + ++ L E + +E P
Sbjct: 970 FRDVI-LVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPD 1028
Query: 1227 SWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRIN 1285
+ G + F Y + VL+ +++ + G+ + +VG +G GKS++ L R
Sbjct: 1029 KFE--GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFY 1086
Query: 1286 ESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWT 1342
+ G +++DG K+ + LR ++ I+ Q+P+LF S+ N+ D S +E+ +
Sbjct: 1087 DPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVS 1146
Query: 1343 SLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVD 1402
+ + A++ F+ LP K + + G LS GQ+Q + +ARAL+R+ +IL+LDEAT+A+D
Sbjct: 1147 AAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALD 1206
Query: 1403 LETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLF 1462
E++ ++Q + E T + IAHRL+TI + ++V G ++E+G LL Q+G++
Sbjct: 1207 TESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIY 1266
Query: 1463 YSM 1465
+SM
Sbjct: 1267 FSM 1269
Score = 137 bits (345), Expect = 8e-32
Identities = 139/547 (25%), Positives = 253/547 (46%), Gaps = 31/547 (5%)
Query: 934 NYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHV-- 991
N+ LSL I+ E R + Y + G+ G+ V Y + VS + A R +
Sbjct: 97 NFSLSLLNPGKIL----EEEMTRYAYYYS-GLGAGVLVAAY-IQVSFWTLAAGRQIRKIR 150
Query: 992 -DLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVIL 1050
H+ILR + +F+ + L R + ++ + I + + MF ++ IV
Sbjct: 151 QKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGF 210
Query: 1051 LA----TPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVI 1106
+ T + I P LGL + A S K L + +++ + E L + +
Sbjct: 211 IRGWKLTLVIMAISPILGLSAAVWAKILSAFSD--KELAAYAKAGAVAE--EALGAIRTV 266
Query: 1107 RAF----EEQERFI-HQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVI 1161
AF +E ER+ H + K +KA +I + +A L + + VI
Sbjct: 267 IAFGGQNKELERYQKHLENAKEIGIKKAISANI--SMGIAFLLIYASYALAFWYGSTLVI 324
Query: 1162 SRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV-AVERLKEYSETEKEAPWQIQ 1220
S+ ++V +S+ + + + N A + + + + +
Sbjct: 325 SKEYTIGN--AMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSE 382
Query: 1221 ETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTL 1279
P S G +EF + Y + +L+ +N+ + G+ V +VG +G GKS+
Sbjct: 383 RGHKPDSIK--GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQ 440
Query: 1280 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYSDE 1338
+ R+ + EG I IDG +I ++ LR I ++ Q+PVLFS ++ N+ + +
Sbjct: 441 LIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMD 500
Query: 1339 EVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT 1398
E+ +++ A+ +F+ LP K D E G LS GQ+Q + +ARAL+R KIL+LDEAT
Sbjct: 501 EIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEAT 560
Query: 1399 AAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1458
+A+D E++ +Q+ + E T + IAHRL+T+ + + + G I E G+ S+L+++
Sbjct: 561 SALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKK 620
Query: 1459 RGLFYSM 1465
G+++ +
Sbjct: 621 EGVYFKL 627
Score = 77.4 bits (189), Expect = 9e-14
Identities = 41/118 (34%), Positives = 67/118 (56%), Gaps = 3/118 (2%)
Query: 697 KVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKG 756
K E V KG LSGGQKQR+++ARA+ I L D+ SA+D K + E + +
Sbjct: 1163 KYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAR- 1221
Query: 757 MLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTE 814
+ +T I++ H +S + D+I+V G++ E G++Q+LLA+ G + + A T+
Sbjct: 1222 --EGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1277
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 177 bits (449), Expect = 7e-44
Identities = 143/488 (29%), Positives = 238/488 (48%), Gaps = 21/488 (4%)
Query: 989 LHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIK--MFMGSLFNVIGAC 1046
L L SILR ++FF++T +G L+NR S + + + E + + G+ +V G
Sbjct: 247 LRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASV-GIS 305
Query: 1047 IVILLATPIAAII---IPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGV 1103
++ ++ +A + +PP+ +I R+ R+L ++ S + E + V
Sbjct: 306 MMFFVSPNLATFVLSVVPPVSIIAVIYGRYL----RKLTKVTQDSLAQATQLAEERIGNV 361
Query: 1104 SVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFA---V 1160
+RAF ++ I + KVD + A GN IVL + L+ +
Sbjct: 362 RTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVL-SVLYKGGLL 420
Query: 1161 ISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQ 1220
+ ++ G + + Y+ V + L SE+ + A RL E E E + P+
Sbjct: 421 MGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEG 480
Query: 1221 ETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTL 1279
S+ G +EF+N Y + + + +++I G +VG +G+GKS++
Sbjct: 481 VILNEKSFQ--GALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLS 538
Query: 1280 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL----DPFSQY 1335
L R+ + A G I +DG +I ++ LR KI + Q+P+LFS S+ N+ D S
Sbjct: 539 LLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSV 598
Query: 1336 SDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLD 1395
+ EE+ E+A+ F+ P + E G LS GQ+Q + +ARALL+ KIL+LD
Sbjct: 599 TAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLD 658
Query: 1396 EATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDL 1455
EAT+A+D E + L+Q + + TVL IAHRL+TI + V VLD+G+I EYG +L
Sbjct: 659 EATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEEL 718
Query: 1456 LQQRGLFY 1463
L + Y
Sbjct: 719 LSKPNGIY 726
Score = 68.9 bits (167), Expect = 3e-11
Identities = 35/98 (35%), Positives = 63/98 (64%), Gaps = 3/98 (3%)
Query: 702 VAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNK 761
V KGV LSGGQKQR+++ARA+ N I L D+ SA+DA +++ + + ++ +
Sbjct: 627 VGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAE-NEYLVQEAL--DRLMDGR 683
Query: 762 TRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR 799
T +++ H +S + +++ V+ GKI+E G ++ELL++
Sbjct: 684 TVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSK 721
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 175 bits (444), Expect = 3e-43
Identities = 182/790 (23%), Positives = 336/790 (42%), Gaps = 55/790 (6%)
Query: 697 KVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKG 756
K + V +G LSGGQKQR+++ARA+ N I L D+ SA+D + + +
Sbjct: 521 KFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAR- 579
Query: 757 MLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQE 816
+ +T I++ H +S + DVI G I E GS+ EL+ ++G + + + S Q
Sbjct: 580 --EGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQI 637
Query: 817 QDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQ 876
Q +EE + + A L S K L+ S + +
Sbjct: 638 Q-SEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVE--------TDGL 688
Query: 877 KAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYW 936
+A K+++ +K + W Y +G + + L S + S
Sbjct: 689 EANVPPVSFLKVLKLNKTE---------WPYF-VVGTVCAIANGGLQPA--FSVIFSEII 736
Query: 937 LSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHS 996
D V Q+ + ++ LGI F G + +R L +
Sbjct: 737 AIFGPGDDAVK--QQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKA 794
Query: 997 ILRSPMSFFE--RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILL--- 1051
+LR MS+F+ + +G L R + + V + + ++ N+ I+ +
Sbjct: 795 MLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGW 854
Query: 1052 -ATPIAAIIIPPLGLIYFFVQRFYVASS-RQLKRLESVSRSPVYSHFN-ETLLGVSVIRA 1108
T + ++P + + + ++ R K LE+ + + N T++ ++ R
Sbjct: 855 QLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERK 914
Query: 1109 FEEQ--ERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSL 1166
FE E+ V QKA+ I + A C A L +++ H
Sbjct: 915 FESMYVEKLYGPYRNSV---QKAHIYGITFSISQAFMYFSYAGCFRFGAYL--IVNGHMR 969
Query: 1167 SAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPS 1226
++ L S + L + + ++ L E + +E P
Sbjct: 970 FRDVI-LVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPD 1028
Query: 1227 SWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRIN 1285
+ G + F Y + VL+ +++ + G+ + +VG +G GKS++ L R
Sbjct: 1029 KFE--GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFY 1086
Query: 1286 ESAEGEI-------IIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQY 1335
+ G + ++DG K+ + LR ++ I+ Q+P+LF S+ N+ D
Sbjct: 1087 DPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVV 1146
Query: 1336 SDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLD 1395
S +E+ ++ + A++ F+ LP K + + G LS GQ+Q + +ARAL+R+ +IL+LD
Sbjct: 1147 SQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLD 1206
Query: 1396 EATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDL 1455
EAT+A+D E++ ++Q + E T + IAHRL+TI + ++V G ++E+G L
Sbjct: 1207 EATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQL 1266
Query: 1456 LQQRGLFYSM 1465
L Q+G+++SM
Sbjct: 1267 LAQKGIYFSM 1276
Score = 137 bits (345), Expect = 8e-32
Identities = 139/547 (25%), Positives = 253/547 (46%), Gaps = 31/547 (5%)
Query: 934 NYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHV-- 991
N+ LSL I+ E R + Y + G+ G+ V Y + VS + A R +
Sbjct: 97 NFSLSLLNPGKIL----EEEMTRYAYYYS-GLGAGVLVAAY-IQVSFWTLAAGRQIRKIR 150
Query: 992 -DLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVIL 1050
H+ILR + +F+ + L R + ++ + I + + MF ++ IV
Sbjct: 151 QKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGF 210
Query: 1051 LA----TPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVI 1106
+ T + I P LGL + A S K L + +++ + E L + +
Sbjct: 211 IRGWKLTLVIMAISPILGLSAAVWAKILSAFSD--KELAAYAKAGAVAE--EALGAIRTV 266
Query: 1107 RAF----EEQERFI-HQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVI 1161
AF +E ER+ H + K +KA +I + +A L + + VI
Sbjct: 267 IAFGGQNKELERYQKHLENAKEIGIKKAISANI--SMGIAFLLIYASYALAFWYGSTLVI 324
Query: 1162 SRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV-AVERLKEYSETEKEAPWQIQ 1220
S+ ++V +S+ + + + N A + + + + +
Sbjct: 325 SKEYTIGN--AMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSE 382
Query: 1221 ETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTL 1279
P S G +EF + Y + +L+ +N+ + G+ V +VG +G GKS+
Sbjct: 383 RGHKPDSIK--GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQ 440
Query: 1280 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYSDE 1338
+ R+ + EG I IDG +I ++ LR I ++ Q+PVLFS ++ N+ + +
Sbjct: 441 LIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMD 500
Query: 1339 EVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT 1398
E+ +++ A+ +F+ LP K D E G LS GQ+Q + +ARAL+R KIL+LDEAT
Sbjct: 501 EIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEAT 560
Query: 1399 AAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1458
+A+D E++ +Q+ + E T + IAHRL+T+ + + + G I E G+ S+L+++
Sbjct: 561 SALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKK 620
Query: 1459 RGLFYSM 1465
G+++ +
Sbjct: 621 EGVYFKL 627
Score = 77.4 bits (189), Expect = 9e-14
Identities = 41/118 (34%), Positives = 67/118 (56%), Gaps = 3/118 (2%)
Query: 697 KVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKG 756
K E V KG LSGGQKQR+++ARA+ I L D+ SA+D K + E + +
Sbjct: 1170 KYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAR- 1228
Query: 757 MLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTE 814
+ +T I++ H +S + D+I+V G++ E G++Q+LLA+ G + + A T+
Sbjct: 1229 --EGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1284
>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 162 bits (409), Expect = 3e-39
Identities = 131/489 (26%), Positives = 235/489 (48%), Gaps = 28/489 (5%)
Query: 993 LLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLA 1052
L S++ SFF+ +G+L++R + + V ++ + I +F+ + V G +V + +
Sbjct: 265 LFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGV-VVFMFS 323
Query: 1053 TPIAAIIIPPLGL-IYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF-- 1109
++ +G I V Y ++L + + + + ET+ + +R+F
Sbjct: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
Query: 1110 EEQERFIH----QSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHS 1165
EE+E ++ Q K++ + A Y V L + + V +L+ VIS
Sbjct: 384 EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVS---ILYYGGHLVISGQM 440
Query: 1166 LSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPP 1225
S L+ + Y + + + + S + + A E++ E+ + + P + + +
Sbjct: 441 TSGNLIAFII-YEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQ---PTMVHDGSLA 496
Query: 1226 SSWPQVGRVEFRNYCLRYR-EDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRI 1284
+ GRV+F N YR VL++++ +++ G+ +VG +G+GKSS L
Sbjct: 497 PDHLE-GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENF 555
Query: 1285 NESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD------PFSQYSDE 1338
G +++DG I+ L I+++ Q+PVLF+ S+ N+ PF E
Sbjct: 556 YPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPF-----E 610
Query: 1339 EVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT 1398
V + + A+ F+ L D E E G LS GQ+Q V +ARAL+R +L+LDEAT
Sbjct: 611 MVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEAT 670
Query: 1399 AAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1458
+A+D E++ LIQ I + TVL IAHRL+T+ ++VLDKG + + G LL Q
Sbjct: 671 SALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ 730
Query: 1459 RGLFYSMAK 1467
GL+ + +
Sbjct: 731 GGLYAKLVQ 739
Score = 74.3 bits (181), Expect = 8e-13
Identities = 36/104 (34%), Positives = 67/104 (64%), Gaps = 3/104 (2%)
Query: 705 KGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRI 764
KG LSGGQKQRV++ARA+ N + + D+ SA+DA +++ + I G L+ T +
Sbjct: 639 KGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAE-SEYLIQQAI--HGNLQKHTVL 695
Query: 765 LVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLR 808
++ H +S + +I+V+ G++ + G++Q+LLA+ G +A+ ++
Sbjct: 696 IIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQ 739
Score = 42.7 bits (99), Expect = 0.003
Identities = 69/335 (20%), Positives = 143/335 (42%), Gaps = 37/335 (11%)
Query: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATY-INMIWSAPLQVI 452
R+ + ++R + S + G++++ ++ D DL + IN+ ++V
Sbjct: 256 RLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVT 315
Query: 453 -LALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMN---EI 508
+ +++ L+ S++ + ++M+ N + K Y+ + ++ + N E
Sbjct: 316 GVVVFMFSLSWQLSLVTFMGFPIIMMVSN----IYGKYYKRLSKEVQNALARASNTAEET 371
Query: 509 LNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVY 568
++ +K ++ +A E + L Q+ K+ +K A +A + W L+ + +Y
Sbjct: 372 ISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA--AAYMYYVWGSGLTLLVVQVSILY 429
Query: 569 VTIDENNILDAQTAFVSLALFNILRFPLN----ILPMVISSIVQASVSLKRLRIFLSHE- 623
+ ++ Q +L F I F L + V S ++Q + +++ F+ +
Sbjct: 430 Y--GGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQP 487
Query: 624 ------ELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT--LNGITFSIPEGALVA 675
L PD +E R + N TFT+ R+ P T L ++FS+ G + A
Sbjct: 488 TMVHDGSLAPDHLEGR----------VDFENVTFTY-RTRPHTQVLQNVSFSLSPGKVTA 536
Query: 676 VVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNLS 710
+VG G GKSS ++ L G V + G +S
Sbjct: 537 LVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPIS 571
>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 162 bits (409), Expect = 3e-39
Identities = 131/489 (26%), Positives = 235/489 (48%), Gaps = 28/489 (5%)
Query: 993 LLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLA 1052
L S++ SFF+ +G+L++R + + V ++ + I +F+ + V G +V + +
Sbjct: 265 LFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGV-VVFMFS 323
Query: 1053 TPIAAIIIPPLGL-IYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF-- 1109
++ +G I V Y ++L + + + + ET+ + +R+F
Sbjct: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
Query: 1110 EEQERFIH----QSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHS 1165
EE+E ++ Q K++ + A Y V L + + V +L+ VIS
Sbjct: 384 EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVS---ILYYGGHLVISGQM 440
Query: 1166 LSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPP 1225
S L+ + Y + + + + S + + A E++ E+ + + P + + +
Sbjct: 441 TSGNLIAFII-YEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQ---PTMVHDGSLA 496
Query: 1226 SSWPQVGRVEFRNYCLRYR-EDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRI 1284
+ GRV+F N YR VL++++ +++ G+ +VG +G+GKSS L
Sbjct: 497 PDHLE-GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENF 555
Query: 1285 NESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD------PFSQYSDE 1338
G +++DG I+ L I+++ Q+PVLF+ S+ N+ PF E
Sbjct: 556 YPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPF-----E 610
Query: 1339 EVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT 1398
V + + A+ F+ L D E E G LS GQ+Q V +ARAL+R +L+LDEAT
Sbjct: 611 MVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEAT 670
Query: 1399 AAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1458
+A+D E++ LIQ I + TVL IAHRL+T+ ++VLDKG + + G LL Q
Sbjct: 671 SALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ 730
Query: 1459 RGLFYSMAK 1467
GL+ + +
Sbjct: 731 GGLYAKLVQ 739
Score = 74.3 bits (181), Expect = 8e-13
Identities = 36/104 (34%), Positives = 67/104 (64%), Gaps = 3/104 (2%)
Query: 705 KGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRI 764
KG LSGGQKQRV++ARA+ N + + D+ SA+DA +++ + I G L+ T +
Sbjct: 639 KGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAE-SEYLIQQAI--HGNLQKHTVL 695
Query: 765 LVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLR 808
++ H +S + +I+V+ G++ + G++Q+LLA+ G +A+ ++
Sbjct: 696 IIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQ 739
Score = 42.7 bits (99), Expect = 0.003
Identities = 69/335 (20%), Positives = 143/335 (42%), Gaps = 37/335 (11%)
Query: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATY-INMIWSAPLQVI 452
R+ + ++R + S + G++++ ++ D DL + IN+ ++V
Sbjct: 256 RLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVT 315
Query: 453 -LALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMN---EI 508
+ +++ L+ S++ + ++M+ N + K Y+ + ++ + N E
Sbjct: 316 GVVVFMFSLSWQLSLVTFMGFPIIMMVSN----IYGKYYKRLSKEVQNALARASNTAEET 371
Query: 509 LNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVY 568
++ +K ++ +A E + L Q+ K+ +K A +A + W L+ + +Y
Sbjct: 372 ISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA--AAYMYYVWGSGLTLLVVQVSILY 429
Query: 569 VTIDENNILDAQTAFVSLALFNILRFPLN----ILPMVISSIVQASVSLKRLRIFLSHE- 623
+ ++ Q +L F I F L + V S ++Q + +++ F+ +
Sbjct: 430 Y--GGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQP 487
Query: 624 ------ELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT--LNGITFSIPEGALVA 675
L PD +E R + N TFT+ R+ P T L ++FS+ G + A
Sbjct: 488 TMVHDGSLAPDHLEGR----------VDFENVTFTY-RTRPHTQVLQNVSFSLSPGKVTA 536
Query: 676 VVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNLS 710
+VG G GKSS ++ L G V + G +S
Sbjct: 537 LVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPIS 571
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.136 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,069,569
Number of Sequences: 37866
Number of extensions: 2146005
Number of successful extensions: 6284
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 72
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 5672
Number of HSP's gapped (non-prelim): 402
length of query: 1472
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1357
effective length of database: 13,892,928
effective search space: 18852703296
effective search space used: 18852703296
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.