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Search of human proteins with 55769546
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55769546 PAK1 interacting protein 1 [Homo sapiens]
(392 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55769546 PAK1 interacting protein 1 [Homo sapiens] 795 0.0
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 80 4e-15
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 80 4e-15
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 74 2e-13
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 74 2e-13
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 73 4e-13
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 73 4e-13
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 73 4e-13
gi|16554629 WD repeat domain 5 [Homo sapiens] 70 3e-12
gi|16554627 WD repeat domain 5 [Homo sapiens] 70 3e-12
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 67 2e-11
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 67 2e-11
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 67 2e-11
gi|26665869 WD repeat domain 51B [Homo sapiens] 67 2e-11
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 67 3e-11
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 66 5e-11
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 66 5e-11
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 66 5e-11
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 66 5e-11
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 66 5e-11
gi|118402582 cell division cycle 20 [Homo sapiens] 65 1e-10
gi|23199987 WD repeat domain 5B [Homo sapiens] 65 1e-10
gi|32189425 WD repeat domain 69 [Homo sapiens] 64 2e-10
gi|66932902 SREBF chaperone protein [Homo sapiens] 63 5e-10
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 62 7e-10
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 62 9e-10
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 61 2e-09
gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)... 61 2e-09
gi|113865883 WD repeat domain 38 [Homo sapiens] 61 2e-09
gi|21071067 TBP-associated factor 5 [Homo sapiens] 59 8e-09
>gi|55769546 PAK1 interacting protein 1 [Homo sapiens]
Length = 392
Score = 795 bits (2054), Expect = 0.0
Identities = 392/392 (100%), Positives = 392/392 (100%)
Query: 1 MELVAGCYEQVLFGFAVHPEPEACGDHEQWTLVADFTHHAHTASLSAVAVNSRFVVTGSK 60
MELVAGCYEQVLFGFAVHPEPEACGDHEQWTLVADFTHHAHTASLSAVAVNSRFVVTGSK
Sbjct: 1 MELVAGCYEQVLFGFAVHPEPEACGDHEQWTLVADFTHHAHTASLSAVAVNSRFVVTGSK 60
Query: 61 DETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGAEDGLICIWDAKKWECLKSIK 120
DETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGAEDGLICIWDAKKWECLKSIK
Sbjct: 61 DETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGAEDGLICIWDAKKWECLKSIK 120
Query: 121 AHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGEQYV 180
AHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGEQYV
Sbjct: 121 AHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGEQYV 180
Query: 181 VIIQNKIDIYQLDTASISGTITNEKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCE 240
VIIQNKIDIYQLDTASISGTITNEKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCE
Sbjct: 181 VIIQNKIDIYQLDTASISGTITNEKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCE 240
Query: 241 FKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWKLKQDKKVPPSLLCEINTNARLTCLG 300
FKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWKLKQDKKVPPSLLCEINTNARLTCLG
Sbjct: 241 FKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWKLKQDKKVPPSLLCEINTNARLTCLG 300
Query: 301 VWLDKVADMKESLPPAAEPSPVSKEQSKIGKKEPGDTVHKEEKRSKPNTKKRGLTGDSKK 360
VWLDKVADMKESLPPAAEPSPVSKEQSKIGKKEPGDTVHKEEKRSKPNTKKRGLTGDSKK
Sbjct: 301 VWLDKVADMKESLPPAAEPSPVSKEQSKIGKKEPGDTVHKEEKRSKPNTKKRGLTGDSKK 360
Query: 361 ATKESGLISTKKRKMVEMLEKKRKKKKIKTMQ 392
ATKESGLISTKKRKMVEMLEKKRKKKKIKTMQ
Sbjct: 361 ATKESGLISTKKRKMVEMLEKKRKKKKIKTMQ 392
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 79.7 bits (195), Expect = 4e-15
Identities = 66/265 (24%), Positives = 115/265 (43%), Gaps = 32/265 (12%)
Query: 39 HAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVH----HSGTITCLKFYGNR 94
H A + + RF+ T S D+ + I++ G LVH HS + C F +
Sbjct: 656 HEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMT----GELVHTYDEHSEQVNCCHFTNSS 711
Query: 95 H---LISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN 151
H L +G+ D + +WD + EC ++ H V P KL S D TL+ W+
Sbjct: 712 HHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
Query: 152 LVEGRSAFIKNIKQ----------NAHIV----EWSPRGEQYVVIIQNKIDIYQLDTASI 197
N+KQ + ++ WS G + +V +NKI ++ + T+ +
Sbjct: 772 ATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGL 831
Query: 198 SGTI--TNEKRISSVKFLSESVLA-VAGDEEVIRFFDCDSLVCLCEFKAHENRVKD-MFS 253
G I + I F ++ LA VA + + ++ DS + + + H + V MFS
Sbjct: 832 LGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFS 891
Query: 254 FEIPEHHVIVSASSDGFIKMWKLKQ 278
P+ +++S D I++W+ K+
Sbjct: 892 ---PDGSSFLTSSDDQTIRLWETKK 913
Score = 48.5 bits (114), Expect = 1e-05
Identities = 45/174 (25%), Positives = 74/174 (42%), Gaps = 19/174 (10%)
Query: 25 GDHEQWTLVA-----DFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALV 79
G + W ++ DF H T ++ ++ + S D+T I+ + L
Sbjct: 1065 GTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELR 1124
Query: 80 HHSGTITCLKFYGNRHLI-SGAEDGLICIWDAKKWECL--------KSIKAHKGQVTFLS 130
H+G + C F + L+ +G ++G I IW+ E L + H G VT L
Sbjct: 1125 GHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLC 1184
Query: 131 IHPSGKLALSVGTDKTLRTWNLVEGRSA--FIKNIKQNAHIVEWSPRGEQYVVI 182
P GK+ +S G ++ WN+V G S+ F N N + SP + YV +
Sbjct: 1185 FSPDGKMLISAG--GYIKWWNVVTGESSQTFYTN-GTNLKKIHVSPDFKTYVTV 1235
Score = 35.8 bits (81), Expect = 0.068
Identities = 32/163 (19%), Positives = 66/163 (40%), Gaps = 10/163 (6%)
Query: 119 IKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGEQ 178
++ H V G+ S G DKTL+ + G ++ + ++
Sbjct: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 670
Query: 179 YVVI--IQNKIDIYQLDTASISGTI-TNEKRISSVKFLSES---VLAVAGDEEVIRFFDC 232
++ + K+ I+ T + T + ++++ F + S +LA + ++ +D
Sbjct: 671 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 730
Query: 233 DSLVCLCEFKAHENRVKD-MFSFEIPEHHVIVSASSDGFIKMW 274
+ C H N V FS P+ ++ S S+DG +K+W
Sbjct: 731 NQKECRNTMFGHTNSVNHCRFS---PDDKLLASCSADGTLKLW 770
Score = 35.0 bits (79), Expect = 0.12
Identities = 41/195 (21%), Positives = 82/195 (42%), Gaps = 24/195 (12%)
Query: 94 RHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN-- 151
+++ G E+G I I + +S HK V + K +S D ++ WN
Sbjct: 974 QYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQ 1033
Query: 152 -----LVEGRSAFIKNIK--QNAHIVEWSPRGEQYV--VIIQNKIDIYQLDTASISGTIT 202
+ G +K+ + +N+ ++ WS G V +I NK + D GT+
Sbjct: 1034 LDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNK----EKDFVCHQGTVL 1089
Query: 203 N-EKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHV 261
+ + + KF S S ++ + + D L+ L E + H V+ +F + + +
Sbjct: 1090 SCDISHDATKFSSTSA------DKTAKIWSFDLLLPLHELRGHNGCVR-CSAFSV-DSTL 1141
Query: 262 IVSASSDGFIKMWKL 276
+ + +G I++W +
Sbjct: 1142 LATGDDNGEIRIWNV 1156
Score = 34.3 bits (77), Expect = 0.20
Identities = 26/115 (22%), Positives = 45/115 (39%), Gaps = 5/115 (4%)
Query: 39 HAHTASLSAVAVNSRFVVTGSKDETIHIYD--MKKKIEHGALVHHSGTITCLKFYGNRHL 96
H T + + +++ S D I +++ + K I L H T+ + N L
Sbjct: 1002 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI---FLRGHQETVKDFRLLKNSRL 1058
Query: 97 ISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN 151
+S + DG + +W+ K H+G V I S DKT + W+
Sbjct: 1059 LSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWS 1113
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 79.7 bits (195), Expect = 4e-15
Identities = 66/265 (24%), Positives = 115/265 (43%), Gaps = 32/265 (12%)
Query: 39 HAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVH----HSGTITCLKFYGNR 94
H A + + RF+ T S D+ + I++ G LVH HS + C F +
Sbjct: 645 HEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMT----GELVHTYDEHSEQVNCCHFTNSS 700
Query: 95 H---LISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN 151
H L +G+ D + +WD + EC ++ H V P KL S D TL+ W+
Sbjct: 701 HHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
Query: 152 LVEGRSAFIKNIKQ----------NAHIV----EWSPRGEQYVVIIQNKIDIYQLDTASI 197
N+KQ + ++ WS G + +V +NKI ++ + T+ +
Sbjct: 761 ATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGL 820
Query: 198 SGTI--TNEKRISSVKFLSESVLA-VAGDEEVIRFFDCDSLVCLCEFKAHENRVKD-MFS 253
G I + I F ++ LA VA + + ++ DS + + + H + V MFS
Sbjct: 821 LGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFS 880
Query: 254 FEIPEHHVIVSASSDGFIKMWKLKQ 278
P+ +++S D I++W+ K+
Sbjct: 881 ---PDGSSFLTSSDDQTIRLWETKK 902
Score = 48.5 bits (114), Expect = 1e-05
Identities = 45/174 (25%), Positives = 74/174 (42%), Gaps = 19/174 (10%)
Query: 25 GDHEQWTLVA-----DFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALV 79
G + W ++ DF H T ++ ++ + S D+T I+ + L
Sbjct: 1054 GTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELR 1113
Query: 80 HHSGTITCLKFYGNRHLI-SGAEDGLICIWDAKKWECL--------KSIKAHKGQVTFLS 130
H+G + C F + L+ +G ++G I IW+ E L + H G VT L
Sbjct: 1114 GHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLC 1173
Query: 131 IHPSGKLALSVGTDKTLRTWNLVEGRSA--FIKNIKQNAHIVEWSPRGEQYVVI 182
P GK+ +S G ++ WN+V G S+ F N N + SP + YV +
Sbjct: 1174 FSPDGKMLISAG--GYIKWWNVVTGESSQTFYTN-GTNLKKIHVSPDFKTYVTV 1224
Score = 35.8 bits (81), Expect = 0.068
Identities = 32/163 (19%), Positives = 66/163 (40%), Gaps = 10/163 (6%)
Query: 119 IKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGEQ 178
++ H V G+ S G DKTL+ + G ++ + ++
Sbjct: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 659
Query: 179 YVVI--IQNKIDIYQLDTASISGTI-TNEKRISSVKFLSES---VLAVAGDEEVIRFFDC 232
++ + K+ I+ T + T + ++++ F + S +LA + ++ +D
Sbjct: 660 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 719
Query: 233 DSLVCLCEFKAHENRVKD-MFSFEIPEHHVIVSASSDGFIKMW 274
+ C H N V FS P+ ++ S S+DG +K+W
Sbjct: 720 NQKECRNTMFGHTNSVNHCRFS---PDDKLLASCSADGTLKLW 759
Score = 35.0 bits (79), Expect = 0.12
Identities = 41/195 (21%), Positives = 82/195 (42%), Gaps = 24/195 (12%)
Query: 94 RHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN-- 151
+++ G E+G I I + +S HK V + K +S D ++ WN
Sbjct: 963 QYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQ 1022
Query: 152 -----LVEGRSAFIKNIK--QNAHIVEWSPRGEQYV--VIIQNKIDIYQLDTASISGTIT 202
+ G +K+ + +N+ ++ WS G V +I NK + D GT+
Sbjct: 1023 LDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNK----EKDFVCHQGTVL 1078
Query: 203 N-EKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHV 261
+ + + KF S S ++ + + D L+ L E + H V+ +F + + +
Sbjct: 1079 SCDISHDATKFSSTSA------DKTAKIWSFDLLLPLHELRGHNGCVR-CSAFSV-DSTL 1130
Query: 262 IVSASSDGFIKMWKL 276
+ + +G I++W +
Sbjct: 1131 LATGDDNGEIRIWNV 1145
Score = 34.3 bits (77), Expect = 0.20
Identities = 26/115 (22%), Positives = 45/115 (39%), Gaps = 5/115 (4%)
Query: 39 HAHTASLSAVAVNSRFVVTGSKDETIHIYD--MKKKIEHGALVHHSGTITCLKFYGNRHL 96
H T + + +++ S D I +++ + K I L H T+ + N L
Sbjct: 991 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI---FLRGHQETVKDFRLLKNSRL 1047
Query: 97 ISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN 151
+S + DG + +W+ K H+G V I S DKT + W+
Sbjct: 1048 LSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWS 1102
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 74.3 bits (181), Expect = 2e-13
Identities = 58/243 (23%), Positives = 114/243 (46%), Gaps = 20/243 (8%)
Query: 55 VVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGAEDGLICIWDAKKWE 114
+V+G +D TI I+D L H+G++ CL+ Y R +I+G+ D + +WD E
Sbjct: 280 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQ-YDERVIITGSSDSTVRVWDVNTGE 338
Query: 115 CLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNI----KQNAHIV 170
L ++ H V L + + + ++ D+++ W++ ++ + + ++V
Sbjct: 339 MLNTLIHHCEAV--LHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV 396
Query: 171 EWSPRGEQYVVII--QNKIDIYQLDTASISGTITNEKR-ISSVKFLSESVLAVAGDEEVI 227
++ ++Y+V I ++ T T+ KR I+ +++ V++ + D I
Sbjct: 397 DFD---DKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSD-NTI 452
Query: 228 RFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWKL--KQDKKVPPS 285
R +D + CL + HE V+ + ++ IVS + DG IK+W L D + P
Sbjct: 453 RLWDIECGACLRVLEGHEELVRCIRF----DNKRIVSGAYDGKIKVWDLVAALDPRAPAG 508
Query: 286 LLC 288
LC
Sbjct: 509 TLC 511
Score = 52.8 bits (125), Expect = 5e-07
Identities = 35/131 (26%), Positives = 60/131 (45%), Gaps = 12/131 (9%)
Query: 37 THHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHL 96
T + H ++ + R VV+GS D TI ++D++ L H + C++F N+ +
Sbjct: 425 TLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF-DNKRI 483
Query: 97 ISGAEDGLICIWD---------AKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTL 147
+SGA DG I +WD CL+++ H G+V L +S D T+
Sbjct: 484 VSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEF--QIVSSSHDDTI 541
Query: 148 RTWNLVEGRSA 158
W+ + +A
Sbjct: 542 LIWDFLNDPAA 552
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 74.3 bits (181), Expect = 2e-13
Identities = 58/243 (23%), Positives = 114/243 (46%), Gaps = 20/243 (8%)
Query: 55 VVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGAEDGLICIWDAKKWE 114
+V+G +D TI I+D L H+G++ CL+ Y R +I+G+ D + +WD E
Sbjct: 316 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQ-YDERVIITGSSDSTVRVWDVNTGE 374
Query: 115 CLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNI----KQNAHIV 170
L ++ H V L + + + ++ D+++ W++ ++ + + ++V
Sbjct: 375 MLNTLIHHCEAV--LHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV 432
Query: 171 EWSPRGEQYVVII--QNKIDIYQLDTASISGTITNEKR-ISSVKFLSESVLAVAGDEEVI 227
++ ++Y+V I ++ T T+ KR I+ +++ V++ + D I
Sbjct: 433 DFD---DKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSD-NTI 488
Query: 228 RFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWKL--KQDKKVPPS 285
R +D + CL + HE V+ + ++ IVS + DG IK+W L D + P
Sbjct: 489 RLWDIECGACLRVLEGHEELVRCIRF----DNKRIVSGAYDGKIKVWDLVAALDPRAPAG 544
Query: 286 LLC 288
LC
Sbjct: 545 TLC 547
Score = 52.8 bits (125), Expect = 5e-07
Identities = 35/131 (26%), Positives = 60/131 (45%), Gaps = 12/131 (9%)
Query: 37 THHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHL 96
T + H ++ + R VV+GS D TI ++D++ L H + C++F N+ +
Sbjct: 461 TLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF-DNKRI 519
Query: 97 ISGAEDGLICIWD---------AKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTL 147
+SGA DG I +WD CL+++ H G+V L +S D T+
Sbjct: 520 VSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEF--QIVSSSHDDTI 577
Query: 148 RTWNLVEGRSA 158
W+ + +A
Sbjct: 578 LIWDFLNDPAA 588
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 73.2 bits (178), Expect = 4e-13
Identities = 50/250 (20%), Positives = 112/250 (44%), Gaps = 30/250 (12%)
Query: 41 HTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVH----HSGTITCLKFYGNRHL 96
HT + + + +++GS D T+ +++ E G +H H+ T+ C+ + R +
Sbjct: 302 HTGGVWSSQMRDNIIISGSTDRTLKVWN----AETGECIHTLYGHTSTVRCMHLHEKR-V 356
Query: 97 ISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTW------ 150
+SG+ D + +WD + +CL + H V + G+ +S D ++ W
Sbjct: 357 VSGSRDATLRVWDIETGQCLHVLMGHVAAVR--CVQYDGRRVVSGAYDFMVKVWDPETET 414
Query: 151 --NLVEGRSAFIKNIK-QNAHIVEWSPRGEQYVVIIQNKIDIYQLDTASISGTITNEKRI 207
+ ++G + + +++ H+V S + I ++ ++T + T+T + +
Sbjct: 415 CLHTLQGHTNRVYSLQFDGIHVVSGS---------LDTSIRVWDVETGNCIHTLTGHQSL 465
Query: 208 SSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHVIVSASS 267
+S L +++L + ++ +D + CL + + + ++ VI S S
Sbjct: 466 TSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITS-SD 524
Query: 268 DGFIKMWKLK 277
DG +K+W LK
Sbjct: 525 DGTVKLWDLK 534
Score = 67.4 bits (163), Expect = 2e-11
Identities = 54/201 (26%), Positives = 96/201 (47%), Gaps = 13/201 (6%)
Query: 80 HHSGTITCLKFYGNRHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLAL 139
H ITCL+F GNR ++SG++D + +W A +CL+++ H G V S + +
Sbjct: 261 HDDHVITCLQFCGNR-IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV--WSSQMRDNIII 317
Query: 140 SVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGEQYVVIIQN--KIDIYQLDTASI 197
S TD+TL+ WN G I + + V E+ VV + ++ ++T
Sbjct: 318 SGSTDRTLKVWNAETGEC--IHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQC 375
Query: 198 SGTITNE-KRISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEI 256
+ + V++ V++ A D +++ +D ++ CL + H NRV +S +
Sbjct: 376 LHVLMGHVAAVRCVQYDGRRVVSGAYD-FMVKVWDPETETCLHTLQGHTNRV---YSLQF 431
Query: 257 PEHHVIVSASSDGFIKMWKLK 277
HV VS S D I++W ++
Sbjct: 432 DGIHV-VSGSLDTSIRVWDVE 451
Score = 43.9 bits (102), Expect = 3e-04
Identities = 30/111 (27%), Positives = 56/111 (50%), Gaps = 10/111 (9%)
Query: 41 HTASLSAVAVNSRFVVTGSKDETIHIYDMKK----KIEHGALVHHSGTITCLKFYGNRHL 96
H + S + + +V+G+ D T+ I+D+K + G H S +TCL+F N +
Sbjct: 462 HQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA-VTCLQFNKN-FV 519
Query: 97 ISGAEDGLICIWDAKKWECLKSI----KAHKGQVTFLSIHPSGKLALSVGT 143
I+ ++DG + +WD K E ++++ G V + + KL +VG+
Sbjct: 520 ITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGS 570
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 73.2 bits (178), Expect = 4e-13
Identities = 50/250 (20%), Positives = 112/250 (44%), Gaps = 30/250 (12%)
Query: 41 HTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVH----HSGTITCLKFYGNRHL 96
HT + + + +++GS D T+ +++ E G +H H+ T+ C+ + R +
Sbjct: 420 HTGGVWSSQMRDNIIISGSTDRTLKVWN----AETGECIHTLYGHTSTVRCMHLHEKR-V 474
Query: 97 ISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTW------ 150
+SG+ D + +WD + +CL + H V + G+ +S D ++ W
Sbjct: 475 VSGSRDATLRVWDIETGQCLHVLMGHVAAVR--CVQYDGRRVVSGAYDFMVKVWDPETET 532
Query: 151 --NLVEGRSAFIKNIK-QNAHIVEWSPRGEQYVVIIQNKIDIYQLDTASISGTITNEKRI 207
+ ++G + + +++ H+V S + I ++ ++T + T+T + +
Sbjct: 533 CLHTLQGHTNRVYSLQFDGIHVVSGS---------LDTSIRVWDVETGNCIHTLTGHQSL 583
Query: 208 SSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHVIVSASS 267
+S L +++L + ++ +D + CL + + + ++ VI S S
Sbjct: 584 TSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITS-SD 642
Query: 268 DGFIKMWKLK 277
DG +K+W LK
Sbjct: 643 DGTVKLWDLK 652
Score = 67.4 bits (163), Expect = 2e-11
Identities = 54/201 (26%), Positives = 96/201 (47%), Gaps = 13/201 (6%)
Query: 80 HHSGTITCLKFYGNRHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLAL 139
H ITCL+F GNR ++SG++D + +W A +CL+++ H G V S + +
Sbjct: 379 HDDHVITCLQFCGNR-IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV--WSSQMRDNIII 435
Query: 140 SVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGEQYVVIIQN--KIDIYQLDTASI 197
S TD+TL+ WN G I + + V E+ VV + ++ ++T
Sbjct: 436 SGSTDRTLKVWNAETGEC--IHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQC 493
Query: 198 SGTITNE-KRISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEI 256
+ + V++ V++ A D +++ +D ++ CL + H NRV +S +
Sbjct: 494 LHVLMGHVAAVRCVQYDGRRVVSGAYD-FMVKVWDPETETCLHTLQGHTNRV---YSLQF 549
Query: 257 PEHHVIVSASSDGFIKMWKLK 277
HV VS S D I++W ++
Sbjct: 550 DGIHV-VSGSLDTSIRVWDVE 569
Score = 43.9 bits (102), Expect = 3e-04
Identities = 30/111 (27%), Positives = 56/111 (50%), Gaps = 10/111 (9%)
Query: 41 HTASLSAVAVNSRFVVTGSKDETIHIYDMKK----KIEHGALVHHSGTITCLKFYGNRHL 96
H + S + + +V+G+ D T+ I+D+K + G H S +TCL+F N +
Sbjct: 580 HQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA-VTCLQFNKN-FV 637
Query: 97 ISGAEDGLICIWDAKKWECLKSI----KAHKGQVTFLSIHPSGKLALSVGT 143
I+ ++DG + +WD K E ++++ G V + + KL +VG+
Sbjct: 638 ITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGS 688
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 73.2 bits (178), Expect = 4e-13
Identities = 50/250 (20%), Positives = 112/250 (44%), Gaps = 30/250 (12%)
Query: 41 HTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVH----HSGTITCLKFYGNRHL 96
HT + + + +++GS D T+ +++ E G +H H+ T+ C+ + R +
Sbjct: 340 HTGGVWSSQMRDNIIISGSTDRTLKVWN----AETGECIHTLYGHTSTVRCMHLHEKR-V 394
Query: 97 ISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTW------ 150
+SG+ D + +WD + +CL + H V + G+ +S D ++ W
Sbjct: 395 VSGSRDATLRVWDIETGQCLHVLMGHVAAVR--CVQYDGRRVVSGAYDFMVKVWDPETET 452
Query: 151 --NLVEGRSAFIKNIK-QNAHIVEWSPRGEQYVVIIQNKIDIYQLDTASISGTITNEKRI 207
+ ++G + + +++ H+V S + I ++ ++T + T+T + +
Sbjct: 453 CLHTLQGHTNRVYSLQFDGIHVVSGS---------LDTSIRVWDVETGNCIHTLTGHQSL 503
Query: 208 SSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHVIVSASS 267
+S L +++L + ++ +D + CL + + + ++ VI S S
Sbjct: 504 TSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITS-SD 562
Query: 268 DGFIKMWKLK 277
DG +K+W LK
Sbjct: 563 DGTVKLWDLK 572
Score = 67.4 bits (163), Expect = 2e-11
Identities = 54/201 (26%), Positives = 96/201 (47%), Gaps = 13/201 (6%)
Query: 80 HHSGTITCLKFYGNRHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLAL 139
H ITCL+F GNR ++SG++D + +W A +CL+++ H G V S + +
Sbjct: 299 HDDHVITCLQFCGNR-IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV--WSSQMRDNIII 355
Query: 140 SVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGEQYVVIIQN--KIDIYQLDTASI 197
S TD+TL+ WN G I + + V E+ VV + ++ ++T
Sbjct: 356 SGSTDRTLKVWNAETGEC--IHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQC 413
Query: 198 SGTITNE-KRISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEI 256
+ + V++ V++ A D +++ +D ++ CL + H NRV +S +
Sbjct: 414 LHVLMGHVAAVRCVQYDGRRVVSGAYD-FMVKVWDPETETCLHTLQGHTNRV---YSLQF 469
Query: 257 PEHHVIVSASSDGFIKMWKLK 277
HV VS S D I++W ++
Sbjct: 470 DGIHV-VSGSLDTSIRVWDVE 489
Score = 43.9 bits (102), Expect = 3e-04
Identities = 30/111 (27%), Positives = 56/111 (50%), Gaps = 10/111 (9%)
Query: 41 HTASLSAVAVNSRFVVTGSKDETIHIYDMKK----KIEHGALVHHSGTITCLKFYGNRHL 96
H + S + + +V+G+ D T+ I+D+K + G H S +TCL+F N +
Sbjct: 500 HQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA-VTCLQFNKN-FV 557
Query: 97 ISGAEDGLICIWDAKKWECLKSI----KAHKGQVTFLSIHPSGKLALSVGT 143
I+ ++DG + +WD K E ++++ G V + + KL +VG+
Sbjct: 558 ITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGS 608
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 70.5 bits (171), Expect = 3e-12
Identities = 62/262 (23%), Positives = 115/262 (43%), Gaps = 14/262 (5%)
Query: 36 FTHHAHTASLSAV--AVNSRFVVTGSKDETIHIYDMKK-KIEHGALVHHSGTITCLKFYG 92
FT HT ++S+V + N ++ + S D+ I I+ K E H G
Sbjct: 39 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98
Query: 93 NRHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNL 152
+ L+S ++D + IWD +CLK++K H V + +P L +S D+++R W++
Sbjct: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158
Query: 153 VEGRSAFIKNIKQNAHIVEWSPRGEQYVVIIQNKID----IYQLDTASISGTITNEKR-- 206
G+ +K + ++ V +I+ + D I+ + T+ ++
Sbjct: 159 KTGKC--LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216
Query: 207 ISSVKFLSESVLAVAGD-EEVIRFFDCDSLVCLCEFKAHENRVKDMF-SFEIPEHHVIVS 264
+S VKF +A + ++ +D CL + H+N +F +F + IVS
Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276
Query: 265 ASSDGFIKMWKLKQDKKVPPSL 286
S D + +W L Q K++ L
Sbjct: 277 GSEDNLVYIWNL-QTKEIVQKL 297
Score = 49.3 bits (116), Expect = 6e-06
Identities = 25/106 (23%), Positives = 50/106 (47%), Gaps = 6/106 (5%)
Query: 51 NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCL----KFYGNRHLISGAEDGLIC 106
N ++++ + D T+ ++D K H C+ G + ++SG+ED L+
Sbjct: 225 NGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVY 284
Query: 107 IWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVG--TDKTLRTW 150
IW+ + E ++ ++ H V + HP+ + S DKT++ W
Sbjct: 285 IWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 70.5 bits (171), Expect = 3e-12
Identities = 62/262 (23%), Positives = 115/262 (43%), Gaps = 14/262 (5%)
Query: 36 FTHHAHTASLSAV--AVNSRFVVTGSKDETIHIYDMKK-KIEHGALVHHSGTITCLKFYG 92
FT HT ++S+V + N ++ + S D+ I I+ K E H G
Sbjct: 39 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98
Query: 93 NRHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNL 152
+ L+S ++D + IWD +CLK++K H V + +P L +S D+++R W++
Sbjct: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158
Query: 153 VEGRSAFIKNIKQNAHIVEWSPRGEQYVVIIQNKID----IYQLDTASISGTITNEKR-- 206
G+ +K + ++ V +I+ + D I+ + T+ ++
Sbjct: 159 KTGKC--LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216
Query: 207 ISSVKFLSESVLAVAGD-EEVIRFFDCDSLVCLCEFKAHENRVKDMF-SFEIPEHHVIVS 264
+S VKF +A + ++ +D CL + H+N +F +F + IVS
Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276
Query: 265 ASSDGFIKMWKLKQDKKVPPSL 286
S D + +W L Q K++ L
Sbjct: 277 GSEDNLVYIWNL-QTKEIVQKL 297
Score = 49.3 bits (116), Expect = 6e-06
Identities = 25/106 (23%), Positives = 50/106 (47%), Gaps = 6/106 (5%)
Query: 51 NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCL----KFYGNRHLISGAEDGLIC 106
N ++++ + D T+ ++D K H C+ G + ++SG+ED L+
Sbjct: 225 NGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVY 284
Query: 107 IWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVG--TDKTLRTW 150
IW+ + E ++ ++ H V + HP+ + S DKT++ W
Sbjct: 285 IWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 67.4 bits (163), Expect = 2e-11
Identities = 35/116 (30%), Positives = 62/116 (53%), Gaps = 3/116 (2%)
Query: 40 AHTASLSAV--AVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFY-GNRHL 96
AHTA++ +V + + VT S D+T+ ++ ++ +L H + C KF R +
Sbjct: 63 AHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLI 122
Query: 97 ISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNL 152
+S ++D + +WD EC+ S H G VT++ HPSG + G D T++ W++
Sbjct: 123 VSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
Score = 65.1 bits (157), Expect = 1e-10
Identities = 38/145 (26%), Positives = 71/145 (48%), Gaps = 2/145 (1%)
Query: 37 THHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHL 96
+ H + + + + R +V+ S D+T+ ++D + + H G +T + F+ +
Sbjct: 104 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC 163
Query: 97 ISGAE-DGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEG 155
I+ A D + +WD + L+ + H V LS HPSG ++ +D TL+ +L+EG
Sbjct: 164 IAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEG 223
Query: 156 RSAFIKNIKQN-AHIVEWSPRGEQY 179
R + + Q A V +S GE +
Sbjct: 224 RLLYTLHGHQGPATTVAFSRTGEYF 248
Score = 52.4 bits (124), Expect = 7e-07
Identities = 27/117 (23%), Positives = 55/117 (47%), Gaps = 1/117 (0%)
Query: 36 FTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGN-R 94
FT H + + + + +GS+D+T+ I+ K E H+ T+ + F + +
Sbjct: 19 FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQ 78
Query: 95 HLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN 151
++ ++D + +W + + L S+ H V P G+L +S DKT++ W+
Sbjct: 79 SFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 135
Score = 51.6 bits (122), Expect = 1e-06
Identities = 52/228 (22%), Positives = 101/228 (44%), Gaps = 13/228 (5%)
Query: 61 DETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLI-SGAEDGLICIWDAKKWECLKSI 119
D + ++ MK + H +TC+ F + HL+ SG+ D + IW
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 120 KAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIV---EWSPRG 176
+AH V + G+ ++ DKT++ W R F+ ++ Q+ + V ++SP G
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDG 119
Query: 177 EQYVVIIQNKIDIYQLDTAS---ISGTITNEKRISSVKF-LSESVLAVAGDEEVIRFFDC 232
V +K + D +S + + ++ V F S + +A AG + ++ +D
Sbjct: 120 RLIVSASDDK-TVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
Query: 233 DSLVCLCEFKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWKLKQDK 280
+ L ++ H V + SF P + +++ASSD +K+ L + +
Sbjct: 179 RTHRLLQHYQLHSAAVNGL-SFH-PSGNYLITASSDSTLKILDLMEGR 224
Score = 41.6 bits (96), Expect = 0.001
Identities = 24/100 (24%), Positives = 47/100 (47%), Gaps = 7/100 (7%)
Query: 55 VVTGSKDETIHIYDMKKKIEHGALVH---HSGTITCLKFY-GNRHLISGAEDGLICIWDA 110
+ D T+ ++D++ H L H HS + L F+ +LI+ + D + I D
Sbjct: 164 IAAAGMDNTVKVWDVRT---HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL 220
Query: 111 KKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTW 150
+ L ++ H+G T ++ +G+ S G+D+ + W
Sbjct: 221 MEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 67.4 bits (163), Expect = 2e-11
Identities = 35/116 (30%), Positives = 63/116 (54%), Gaps = 3/116 (2%)
Query: 40 AHTASLSAV--AVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGN-RHL 96
AHTA++ +V + + VT S D+T+ ++ ++ +L H + C KF + R +
Sbjct: 101 AHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLI 160
Query: 97 ISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNL 152
+S ++D + +WD EC+ S H G VT++ HPSG + G D T++ W++
Sbjct: 161 VSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 216
Score = 65.1 bits (157), Expect = 1e-10
Identities = 38/145 (26%), Positives = 71/145 (48%), Gaps = 2/145 (1%)
Query: 37 THHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHL 96
+ H + + + + R +V+ S D+T+ ++D + + H G +T + F+ +
Sbjct: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC 201
Query: 97 ISGAE-DGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEG 155
I+ A D + +WD + L+ + H V LS HPSG ++ +D TL+ +L+EG
Sbjct: 202 IAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEG 261
Query: 156 RSAFIKNIKQN-AHIVEWSPRGEQY 179
R + + Q A V +S GE +
Sbjct: 262 RLLYTLHGHQGPATTVAFSRTGEYF 286
Score = 62.0 bits (149), Expect = 9e-10
Identities = 59/261 (22%), Positives = 116/261 (44%), Gaps = 13/261 (4%)
Query: 28 EQWTLVADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITC 87
E +L F H + ++N++ + +GS D + ++ MK + H +TC
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 88 LKFYGNRHLI-SGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKT 146
+ F + HL+ SG+ D + IW +AH V + G+ ++ DKT
Sbjct: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
Query: 147 LRTWNLVEGRSAFIKNIKQNAHIV---EWSPRGEQYVVIIQNKIDIYQLDTAS---ISGT 200
++ W R F+ ++ Q+ + V ++SP G V +K + D +S +
Sbjct: 127 VKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDK-TVKLWDKSSRECVHSY 183
Query: 201 ITNEKRISSVKF-LSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEH 259
+ ++ V F S + +A AG + ++ +D + L ++ H V + SF P
Sbjct: 184 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGL-SFH-PSG 241
Query: 260 HVIVSASSDGFIKMWKLKQDK 280
+ +++ASSD +K+ L + +
Sbjct: 242 NYLITASSDSTLKILDLMEGR 262
Score = 41.6 bits (96), Expect = 0.001
Identities = 24/100 (24%), Positives = 47/100 (47%), Gaps = 7/100 (7%)
Query: 55 VVTGSKDETIHIYDMKKKIEHGALVH---HSGTITCLKFY-GNRHLISGAEDGLICIWDA 110
+ D T+ ++D++ H L H HS + L F+ +LI+ + D + I D
Sbjct: 202 IAAAGMDNTVKVWDVRT---HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL 258
Query: 111 KKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTW 150
+ L ++ H+G T ++ +G+ S G+D+ + W
Sbjct: 259 MEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 67.4 bits (163), Expect = 2e-11
Identities = 35/116 (30%), Positives = 63/116 (54%), Gaps = 3/116 (2%)
Query: 40 AHTASLSAV--AVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGN-RHL 96
AHTA++ +V + + VT S D+T+ ++ ++ +L H + C KF + R +
Sbjct: 101 AHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLI 160
Query: 97 ISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNL 152
+S ++D + +WD EC+ S H G VT++ HPSG + G D T++ W++
Sbjct: 161 VSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 216
Score = 65.1 bits (157), Expect = 1e-10
Identities = 38/145 (26%), Positives = 71/145 (48%), Gaps = 2/145 (1%)
Query: 37 THHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHL 96
+ H + + + + R +V+ S D+T+ ++D + + H G +T + F+ +
Sbjct: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC 201
Query: 97 ISGAE-DGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEG 155
I+ A D + +WD + L+ + H V LS HPSG ++ +D TL+ +L+EG
Sbjct: 202 IAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEG 261
Query: 156 RSAFIKNIKQN-AHIVEWSPRGEQY 179
R + + Q A V +S GE +
Sbjct: 262 RLLYTLHGHQGPATTVAFSRTGEYF 286
Score = 62.0 bits (149), Expect = 9e-10
Identities = 59/261 (22%), Positives = 116/261 (44%), Gaps = 13/261 (4%)
Query: 28 EQWTLVADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITC 87
E +L F H + ++N++ + +GS D + ++ MK + H +TC
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 88 LKFYGNRHLI-SGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKT 146
+ F + HL+ SG+ D + IW +AH V + G+ ++ DKT
Sbjct: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
Query: 147 LRTWNLVEGRSAFIKNIKQNAHIV---EWSPRGEQYVVIIQNKIDIYQLDTAS---ISGT 200
++ W R F+ ++ Q+ + V ++SP G V +K + D +S +
Sbjct: 127 VKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDK-TVKLWDKSSRECVHSY 183
Query: 201 ITNEKRISSVKF-LSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEH 259
+ ++ V F S + +A AG + ++ +D + L ++ H V + SF P
Sbjct: 184 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGL-SFH-PSG 241
Query: 260 HVIVSASSDGFIKMWKLKQDK 280
+ +++ASSD +K+ L + +
Sbjct: 242 NYLITASSDSTLKILDLMEGR 262
Score = 41.6 bits (96), Expect = 0.001
Identities = 24/100 (24%), Positives = 47/100 (47%), Gaps = 7/100 (7%)
Query: 55 VVTGSKDETIHIYDMKKKIEHGALVH---HSGTITCLKFY-GNRHLISGAEDGLICIWDA 110
+ D T+ ++D++ H L H HS + L F+ +LI+ + D + I D
Sbjct: 202 IAAAGMDNTVKVWDVRT---HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL 258
Query: 111 KKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTW 150
+ L ++ H+G T ++ +G+ S G+D+ + W
Sbjct: 259 MEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 67.4 bits (163), Expect = 2e-11
Identities = 35/116 (30%), Positives = 65/116 (56%), Gaps = 3/116 (2%)
Query: 40 AHTASLSAV--AVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFY-GNRHL 96
AHTA + +V + + +F+ T S+D++I ++ M ++ +L H+ + C KF R +
Sbjct: 100 AHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLI 159
Query: 97 ISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNL 152
+S +ED I IWD +C+ + G F+ +PSG S G+D+T++ W++
Sbjct: 160 VSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDV 215
Score = 57.8 bits (138), Expect = 2e-08
Identities = 34/119 (28%), Positives = 58/119 (48%), Gaps = 1/119 (0%)
Query: 39 HAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLIS 98
H H + + + R +V+ S+D+TI I+D K G + F + I+
Sbjct: 143 HTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIA 202
Query: 99 GA-EDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGR 156
A D + +WD + + L+ + H G V +S HPSG ++ +D TL+ +L+EGR
Sbjct: 203 SAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGR 261
Score = 51.2 bits (121), Expect = 2e-06
Identities = 46/251 (18%), Positives = 99/251 (39%), Gaps = 47/251 (18%)
Query: 36 FTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGN-R 94
+ H + + + + + S+D T+ ++ K+ + H+ + + F + +
Sbjct: 56 YVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ 115
Query: 95 HLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVE 154
L + +ED I +W + L S+ H V P G+L +S DKT++ W+
Sbjct: 116 FLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTN 175
Query: 155 GRSAFIKNIKQN---AHIVEWSPRGEQYVVIIQNKIDIYQLDTASISGTITNEKRISSVK 211
+ + N + A+ V+++P G
Sbjct: 176 KQC--VNNFSDSVGFANFVDFNPSG----------------------------------- 198
Query: 212 FLSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHVIVSASSDGFI 271
+ +A AG ++ ++ +D L ++ H V + SF P + +++ASSDG +
Sbjct: 199 ----TCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGV-NCISFH-PSGNYLITASSDGTL 252
Query: 272 KMWKLKQDKKV 282
K+ L + + +
Sbjct: 253 KILDLLEGRLI 263
Score = 49.7 bits (117), Expect = 5e-06
Identities = 26/99 (26%), Positives = 52/99 (52%), Gaps = 5/99 (5%)
Query: 55 VVTGSKDETIHIYDMK--KKIEHGALVHHSGTITCLKFY-GNRHLISGAEDGLICIWDAK 111
+ + D+T+ ++D++ K ++H + HSG + C+ F+ +LI+ + DG + I D
Sbjct: 201 IASAGSDQTVKVWDVRVNKLLQHYQV--HSGGVNCISFHPSGNYLITASSDGTLKILDLL 258
Query: 112 KWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTW 150
+ + +++ H G V +S G+L S G D + W
Sbjct: 259 EGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 46.6 bits (109), Expect = 4e-05
Identities = 47/206 (22%), Positives = 87/206 (42%), Gaps = 9/206 (4%)
Query: 81 HSGTITCLKFYGN-RHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLAL 139
H IT L N + L + + D + +W+ K HK VT + P G L
Sbjct: 17 HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLA 76
Query: 140 SVGTDKTLRTWNLVEGRSAFIKNIKQNAHI--VEWSPRGEQYVVIIQNK-IDIYQLDTAS 196
S D+T+R W + + R F + A + V++S G+ ++K I ++ +
Sbjct: 77 SASRDRTVRLW-IPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQR 135
Query: 197 ISGTITNEKR-ISSVKFLSESVLAVA-GDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSF 254
++ + KF + L V+ +++ I+ +D + C+ F + + F
Sbjct: 136 FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNF-SDSVGFANFVDF 194
Query: 255 EIPEHHVIVSASSDGFIKMWKLKQDK 280
P I SA SD +K+W ++ +K
Sbjct: 195 N-PSGTCIASAGSDQTVKVWDVRVNK 219
Score = 38.5 bits (88), Expect = 0.011
Identities = 41/160 (25%), Positives = 68/160 (42%), Gaps = 8/160 (5%)
Query: 120 KAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAF-IKNIKQNAHIVEWSPRGEQ 178
K HK +T L + P+GK + D L WN A+ K V++SP G
Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNL 74
Query: 179 YVVIIQNK-IDIYQLD-TASISGTITNEKRISSVKFLSE-SVLAVAGDEEVIRFFDCDSL 235
+++ + ++ D S + + SV F ++ LA A +++ I+ +
Sbjct: 75 LASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQ 134
Query: 236 VCLCEFKAHENRVK-DMFSFEIPEHHVIVSASSDGFIKMW 274
L H + V+ FS P+ +IVS S D IK+W
Sbjct: 135 RFLYSLYRHTHWVRCAKFS---PDGRLIVSCSEDKTIKIW 171
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 67.0 bits (162), Expect = 3e-11
Identities = 52/251 (20%), Positives = 100/251 (39%), Gaps = 43/251 (17%)
Query: 30 WTLVADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLK 89
W L H ++ +SL + R + TG D ++++ + K +L H+ + ++
Sbjct: 11 WKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVR 70
Query: 90 FYGNRHLI-SGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLR 148
LI +G++ G I +WD + + L+++ HK + L HP G+ S D ++
Sbjct: 71 LNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIK 130
Query: 149 TWNLVEGRSAF-IKNIKQNAHIVEWSPRGEQYVVIIQNKIDIYQLDTASISGTITNEKRI 207
W++ F + Q + +SP G+
Sbjct: 131 LWDIRRKGCVFRYRGHSQAVRCLRFSPDGKW----------------------------- 161
Query: 208 SSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHVIVSASS 267
LA A D+ ++ +D + + EF H V ++ F P +++ S SS
Sbjct: 162 ----------LASAADDHTVKLWDLTAGKMMSEFPGHTGPV-NVVEFH-PNEYLLASGSS 209
Query: 268 DGFIKMWKLKQ 278
D I+ W L++
Sbjct: 210 DRTIRFWDLEK 220
Score = 46.6 bits (109), Expect = 4e-05
Identities = 26/118 (22%), Positives = 59/118 (50%), Gaps = 4/118 (3%)
Query: 36 FTHHAHTASLSAV--AVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGN 93
F + H+ ++ + + + +++ + + D T+ ++D+ H+G + ++F+ N
Sbjct: 141 FRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPN 200
Query: 94 RHLI-SGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTW 150
+L+ SG+ D I WD +K++ + I+ G V + +P G L G +LR +
Sbjct: 201 EYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDG-CCLYSGCQDSLRVY 257
Score = 30.4 bits (67), Expect = 2.9
Identities = 29/118 (24%), Positives = 51/118 (43%), Gaps = 11/118 (9%)
Query: 23 ACGDH--EQWTLVA-----DFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEH 75
A DH + W L A +F H ++ N + +GS D TI +D++K
Sbjct: 165 AADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVV 224
Query: 76 GALVHHSGTITCLKFYGNR-HLISGAEDGL-ICIWDAKKWECLKSIKAHKGQVTFLSI 131
+ G + + F + L SG +D L + W+ ++ C + + G+V L+I
Sbjct: 225 SCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPER--CFDVVLVNWGKVADLAI 280
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 66.2 bits (160), Expect = 5e-11
Identities = 52/216 (24%), Positives = 90/216 (41%), Gaps = 27/216 (12%)
Query: 39 HAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVH----HSGTITCLKFYGNR 94
H A + + RF+ T S D+ + I++ G LVH HS + C F +
Sbjct: 656 HEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMT----GELVHTYDEHSEQVNCCHFTNSS 711
Query: 95 H---LISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN 151
H L +G+ D + +WD + EC ++ H V P KL S D TL+ W+
Sbjct: 712 HHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
Query: 152 LVEGRSAFIKNIKQ----------NAHIV----EWSPRGEQYVVIIQNKIDIYQLDTAS- 196
N+KQ + ++ WS G + +V +NKI ++ D+ S
Sbjct: 772 ATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSK 831
Query: 197 ISGTITNEKRISSVKFLSE-SVLAVAGDEEVIRFFD 231
++ + + V F + S + D++ IR ++
Sbjct: 832 VADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 867
Score = 48.5 bits (114), Expect = 1e-05
Identities = 45/174 (25%), Positives = 74/174 (42%), Gaps = 19/174 (10%)
Query: 25 GDHEQWTLVA-----DFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALV 79
G + W ++ DF H T ++ ++ + S D+T I+ + L
Sbjct: 1022 GTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELR 1081
Query: 80 HHSGTITCLKFYGNRHLI-SGAEDGLICIWDAKKWECL--------KSIKAHKGQVTFLS 130
H+G + C F + L+ +G ++G I IW+ E L + H G VT L
Sbjct: 1082 GHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLC 1141
Query: 131 IHPSGKLALSVGTDKTLRTWNLVEGRSA--FIKNIKQNAHIVEWSPRGEQYVVI 182
P GK+ +S G ++ WN+V G S+ F N N + SP + YV +
Sbjct: 1142 FSPDGKMLISAG--GYIKWWNVVTGESSQTFYTN-GTNLKKIHVSPDFKTYVTV 1192
Score = 35.8 bits (81), Expect = 0.068
Identities = 32/163 (19%), Positives = 66/163 (40%), Gaps = 10/163 (6%)
Query: 119 IKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGEQ 178
++ H V G+ S G DKTL+ + G ++ + ++
Sbjct: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 670
Query: 179 YVVI--IQNKIDIYQLDTASISGTIT-NEKRISSVKFLSES---VLAVAGDEEVIRFFDC 232
++ + K+ I+ T + T + ++++ F + S +LA + ++ +D
Sbjct: 671 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 730
Query: 233 DSLVCLCEFKAHENRVKDM-FSFEIPEHHVIVSASSDGFIKMW 274
+ C H N V FS P+ ++ S S+DG +K+W
Sbjct: 731 NQKECRNTMFGHTNSVNHCRFS---PDDKLLASCSADGTLKLW 770
Score = 35.0 bits (79), Expect = 0.12
Identities = 41/195 (21%), Positives = 82/195 (42%), Gaps = 24/195 (12%)
Query: 94 RHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN-- 151
+++ G E+G I I + +S HK V + K +S D ++ WN
Sbjct: 931 QYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQ 990
Query: 152 -----LVEGRSAFIKNIK--QNAHIVEWSPRGEQYV--VIIQNKIDIYQLDTASISGTIT 202
+ G +K+ + +N+ ++ WS G V +I NK + D GT+
Sbjct: 991 LDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNK----EKDFVCHQGTVL 1046
Query: 203 N-EKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHV 261
+ + + KF S S ++ + + D L+ L E + H V+ +F + + +
Sbjct: 1047 SCDISHDATKFSSTSA------DKTAKIWSFDLLLPLHELRGHNGCVR-CSAFSV-DSTL 1098
Query: 262 IVSASSDGFIKMWKL 276
+ + +G I++W +
Sbjct: 1099 LATGDDNGEIRIWNV 1113
Score = 34.3 bits (77), Expect = 0.20
Identities = 26/115 (22%), Positives = 45/115 (39%), Gaps = 5/115 (4%)
Query: 39 HAHTASLSAVAVNSRFVVTGSKDETIHIYD--MKKKIEHGALVHHSGTITCLKFYGNRHL 96
H T + + +++ S D I +++ + K I L H T+ + N L
Sbjct: 959 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI---FLRGHQETVKDFRLLKNSRL 1015
Query: 97 ISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN 151
+S + DG + +W+ K H+G V I S DKT + W+
Sbjct: 1016 LSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWS 1070
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 66.2 bits (160), Expect = 5e-11
Identities = 52/216 (24%), Positives = 90/216 (41%), Gaps = 27/216 (12%)
Query: 39 HAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVH----HSGTITCLKFYGNR 94
H A + + RF+ T S D+ + I++ G LVH HS + C F +
Sbjct: 645 HEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMT----GELVHTYDEHSEQVNCCHFTNSS 700
Query: 95 H---LISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN 151
H L +G+ D + +WD + EC ++ H V P KL S D TL+ W+
Sbjct: 701 HHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
Query: 152 LVEGRSAFIKNIKQ----------NAHIV----EWSPRGEQYVVIIQNKIDIYQLDTAS- 196
N+KQ + ++ WS G + +V +NKI ++ D+ S
Sbjct: 761 ATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSK 820
Query: 197 ISGTITNEKRISSVKFLSE-SVLAVAGDEEVIRFFD 231
++ + + V F + S + D++ IR ++
Sbjct: 821 VADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 856
Score = 48.5 bits (114), Expect = 1e-05
Identities = 45/174 (25%), Positives = 74/174 (42%), Gaps = 19/174 (10%)
Query: 25 GDHEQWTLVA-----DFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALV 79
G + W ++ DF H T ++ ++ + S D+T I+ + L
Sbjct: 1011 GTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELR 1070
Query: 80 HHSGTITCLKFYGNRHLI-SGAEDGLICIWDAKKWECL--------KSIKAHKGQVTFLS 130
H+G + C F + L+ +G ++G I IW+ E L + H G VT L
Sbjct: 1071 GHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLC 1130
Query: 131 IHPSGKLALSVGTDKTLRTWNLVEGRSA--FIKNIKQNAHIVEWSPRGEQYVVI 182
P GK+ +S G ++ WN+V G S+ F N N + SP + YV +
Sbjct: 1131 FSPDGKMLISAG--GYIKWWNVVTGESSQTFYTN-GTNLKKIHVSPDFKTYVTV 1181
Score = 35.8 bits (81), Expect = 0.068
Identities = 32/163 (19%), Positives = 66/163 (40%), Gaps = 10/163 (6%)
Query: 119 IKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGEQ 178
++ H V G+ S G DKTL+ + G ++ + ++
Sbjct: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 659
Query: 179 YVVI--IQNKIDIYQLDTASISGTIT-NEKRISSVKFLSES---VLAVAGDEEVIRFFDC 232
++ + K+ I+ T + T + ++++ F + S +LA + ++ +D
Sbjct: 660 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 719
Query: 233 DSLVCLCEFKAHENRVKDM-FSFEIPEHHVIVSASSDGFIKMW 274
+ C H N V FS P+ ++ S S+DG +K+W
Sbjct: 720 NQKECRNTMFGHTNSVNHCRFS---PDDKLLASCSADGTLKLW 759
Score = 35.0 bits (79), Expect = 0.12
Identities = 41/195 (21%), Positives = 82/195 (42%), Gaps = 24/195 (12%)
Query: 94 RHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN-- 151
+++ G E+G I I + +S HK V + K +S D ++ WN
Sbjct: 920 QYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQ 979
Query: 152 -----LVEGRSAFIKNIK--QNAHIVEWSPRGEQYV--VIIQNKIDIYQLDTASISGTIT 202
+ G +K+ + +N+ ++ WS G V +I NK + D GT+
Sbjct: 980 LDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNK----EKDFVCHQGTVL 1035
Query: 203 N-EKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHV 261
+ + + KF S S ++ + + D L+ L E + H V+ +F + + +
Sbjct: 1036 SCDISHDATKFSSTSA------DKTAKIWSFDLLLPLHELRGHNGCVR-CSAFSV-DSTL 1087
Query: 262 IVSASSDGFIKMWKL 276
+ + +G I++W +
Sbjct: 1088 LATGDDNGEIRIWNV 1102
Score = 34.3 bits (77), Expect = 0.20
Identities = 26/115 (22%), Positives = 45/115 (39%), Gaps = 5/115 (4%)
Query: 39 HAHTASLSAVAVNSRFVVTGSKDETIHIYD--MKKKIEHGALVHHSGTITCLKFYGNRHL 96
H T + + +++ S D I +++ + K I L H T+ + N L
Sbjct: 948 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI---FLRGHQETVKDFRLLKNSRL 1004
Query: 97 ISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWN 151
+S + DG + +W+ K H+G V I S DKT + W+
Sbjct: 1005 LSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWS 1059
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 66.2 bits (160), Expect = 5e-11
Identities = 63/253 (24%), Positives = 112/253 (44%), Gaps = 52/253 (20%)
Query: 41 HTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGA 100
HT S+ + + R +VTGS D T+ ++D+ L+HH+ + L+F N +++ +
Sbjct: 279 HTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF-SNGLMVTCS 337
Query: 101 EDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFI 160
+D I +WD ++ TD TLR LV R+A
Sbjct: 338 KDRSIAVWD-----------------------------MASATDITLRR-VLVGHRAA-- 365
Query: 161 KNIKQNAHIVEWSPRGEQYVVII--QNKIDIYQLDTASISGTITNEKR-ISSVKFLSESV 217
++V++ ++Y+V I ++ T T+ KR I+ +++ V
Sbjct: 366 ------VNVVDFD---DKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLV 416
Query: 218 LAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWKLK 277
++ + D IR +D + CL + HE V+ + ++ IVS + DG IK+W L+
Sbjct: 417 VSGSSD-NTIRLWDIECGACLRVLEGHEELVRCIRF----DNKRIVSGAYDGKIKVWDLQ 471
Query: 278 Q--DKKVPPSLLC 288
D + P S LC
Sbjct: 472 AALDPRAPASTLC 484
Score = 53.9 bits (128), Expect = 2e-07
Identities = 34/126 (26%), Positives = 59/126 (46%), Gaps = 12/126 (9%)
Query: 37 THHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHL 96
T + H ++ + R VV+GS D TI ++D++ L H + C++F N+ +
Sbjct: 398 TLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF-DNKRI 456
Query: 97 ISGAEDGLICIWDAK---------KWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTL 147
+SGA DG I +WD + CL+++ H G+V L +S D T+
Sbjct: 457 VSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEF--QIISSSHDDTI 514
Query: 148 RTWNLV 153
W+ +
Sbjct: 515 LIWDFL 520
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 66.2 bits (160), Expect = 5e-11
Identities = 63/253 (24%), Positives = 112/253 (44%), Gaps = 52/253 (20%)
Query: 41 HTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGA 100
HT S+ + + R +VTGS D T+ ++D+ L+HH+ + L+F N +++ +
Sbjct: 245 HTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF-SNGLMVTCS 303
Query: 101 EDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFI 160
+D I +WD ++ TD TLR LV R+A
Sbjct: 304 KDRSIAVWD-----------------------------MASATDITLRR-VLVGHRAA-- 331
Query: 161 KNIKQNAHIVEWSPRGEQYVVII--QNKIDIYQLDTASISGTITNEKR-ISSVKFLSESV 217
++V++ ++Y+V I ++ T T+ KR I+ +++ V
Sbjct: 332 ------VNVVDFD---DKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLV 382
Query: 218 LAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWKLK 277
++ + D IR +D + CL + HE V+ + ++ IVS + DG IK+W L+
Sbjct: 383 VSGSSD-NTIRLWDIECGACLRVLEGHEELVRCIRF----DNKRIVSGAYDGKIKVWDLQ 437
Query: 278 Q--DKKVPPSLLC 288
D + P S LC
Sbjct: 438 AALDPRAPASTLC 450
Score = 53.9 bits (128), Expect = 2e-07
Identities = 34/126 (26%), Positives = 59/126 (46%), Gaps = 12/126 (9%)
Query: 37 THHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHL 96
T + H ++ + R VV+GS D TI ++D++ L H + C++F N+ +
Sbjct: 364 TLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF-DNKRI 422
Query: 97 ISGAEDGLICIWDAK---------KWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTL 147
+SGA DG I +WD + CL+++ H G+V L +S D T+
Sbjct: 423 VSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEF--QIISSSHDDTI 480
Query: 148 RTWNLV 153
W+ +
Sbjct: 481 LIWDFL 486
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 66.2 bits (160), Expect = 5e-11
Identities = 63/253 (24%), Positives = 112/253 (44%), Gaps = 52/253 (20%)
Query: 41 HTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGA 100
HT S+ + + R +VTGS D T+ ++D+ L+HH+ + L+F N +++ +
Sbjct: 266 HTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF-SNGLMVTCS 324
Query: 101 EDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFI 160
+D I +WD ++ TD TLR LV R+A
Sbjct: 325 KDRSIAVWD-----------------------------MASATDITLRR-VLVGHRAA-- 352
Query: 161 KNIKQNAHIVEWSPRGEQYVVII--QNKIDIYQLDTASISGTITNEKR-ISSVKFLSESV 217
++V++ ++Y+V I ++ T T+ KR I+ +++ V
Sbjct: 353 ------VNVVDFD---DKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLV 403
Query: 218 LAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWKLK 277
++ + D IR +D + CL + HE V+ + ++ IVS + DG IK+W L+
Sbjct: 404 VSGSSD-NTIRLWDIECGACLRVLEGHEELVRCIRF----DNKRIVSGAYDGKIKVWDLQ 458
Query: 278 Q--DKKVPPSLLC 288
D + P S LC
Sbjct: 459 AALDPRAPASTLC 471
Score = 53.9 bits (128), Expect = 2e-07
Identities = 34/126 (26%), Positives = 59/126 (46%), Gaps = 12/126 (9%)
Query: 37 THHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHL 96
T + H ++ + R VV+GS D TI ++D++ L H + C++F N+ +
Sbjct: 385 TLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF-DNKRI 443
Query: 97 ISGAEDGLICIWDAK---------KWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTL 147
+SGA DG I +WD + CL+++ H G+V L +S D T+
Sbjct: 444 VSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEF--QIISSSHDDTI 501
Query: 148 RTWNLV 153
W+ +
Sbjct: 502 LIWDFL 507
>gi|118402582 cell division cycle 20 [Homo sapiens]
Length = 499
Score = 65.1 bits (157), Expect = 1e-10
Identities = 55/210 (26%), Positives = 101/210 (48%), Gaps = 14/210 (6%)
Query: 40 AHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGA-LVHHSGTITCLKFY-GNRHLI 97
+H+A + +++ NS + +GS+ IH +D++ H A L HS + L++ RHL
Sbjct: 266 SHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLA 325
Query: 98 SGAEDGLICIWDAKK----WECLKSIKAHKGQVTFLSIHP--SGKLALSVGT-DKTLRTW 150
SG D L+ +W + W L++ H+G V ++ P S LA GT D+ +R W
Sbjct: 326 SGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW 385
Query: 151 NLVEGRSAFIKNIKQNAHIVEWSPRGEQYVV---IIQNKIDIYQLDT-ASISGTITNEKR 206
N+ G + + WSP ++ + QN++ I++ T A ++ + R
Sbjct: 386 NVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSR 445
Query: 207 ISSVKFLSE-SVLAVAGDEEVIRFFDCDSL 235
+ S+ + + +A A +E +R + C L
Sbjct: 446 VLSLTMSPDGATVASAAADETLRLWRCFEL 475
Score = 41.6 bits (96), Expect = 0.001
Identities = 38/133 (28%), Positives = 58/133 (43%), Gaps = 11/133 (8%)
Query: 30 WTLVADFTHHAHTASLSAVAV---NSRFVVTG--SKDETIHIYDMKKKIEHGALVHHSGT 84
W + FT H ++ AVA S + TG + D I I+++ A+ HS
Sbjct: 345 WVPLQTFTQHQ--GAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQV 402
Query: 85 ITCLKFYGNRHLISG---AEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSV 141
+ L + LISG A++ L+ IW + +K H +V L++ P G S
Sbjct: 403 CSILWSPHYKELISGHGFAQNQLV-IWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASA 461
Query: 142 GTDKTLRTWNLVE 154
D+TLR W E
Sbjct: 462 AADETLRLWRCFE 474
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 64.7 bits (156), Expect = 1e-10
Identities = 58/257 (22%), Positives = 115/257 (44%), Gaps = 14/257 (5%)
Query: 41 HTASLSAV--AVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNR-HLI 97
HT ++S+V + N ++ + S D I I+ L H+ I+ + + + L+
Sbjct: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLV 99
Query: 98 SGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRS 157
S ++D + +WD + +CLK++K H V + +P L +S D+T++ W + G+
Sbjct: 100 SASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKC 159
Query: 158 AFIKNIKQNAHIVEWSPRGEQYVVIIQNKID----IYQLDTASISGTITNEKR--ISSVK 211
+K + ++ V +I+ D I+ + T+ ++ +S VK
Sbjct: 160 --LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVK 217
Query: 212 FL-SESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMF-SFEIPEHHVIVSASSDG 269
F + + A + ++ +D CL + H+N +F +F + IVS S D
Sbjct: 218 FSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 277
Query: 270 FIKMWKLKQDKKVPPSL 286
+ +W L Q K++ L
Sbjct: 278 LVYIWNL-QTKEIVQKL 293
Score = 50.8 bits (120), Expect = 2e-06
Identities = 26/106 (24%), Positives = 51/106 (48%), Gaps = 6/106 (5%)
Query: 51 NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCL----KFYGNRHLISGAEDGLIC 106
N ++++T + D T+ ++D + H C+ G + ++SG+ED L+
Sbjct: 221 NGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVY 280
Query: 107 IWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVG--TDKTLRTW 150
IW+ + E ++ ++ H V + HP+ L S DKT++ W
Sbjct: 281 IWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 64.3 bits (155), Expect = 2e-10
Identities = 54/263 (20%), Positives = 113/263 (42%), Gaps = 14/263 (5%)
Query: 22 EACGDHEQWTLVADFTHHAHTASLSAVAVNSR--FVVTGSKDETIHIYDMKKKIEHGALV 79
E G + T AH L+ VA+N +TGS D T ++D E L
Sbjct: 72 EKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLE 131
Query: 80 HHSGTITCLKF---YGNRHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGK 136
H + + F YG++ + +G+ D +W + +C + + H ++ LS +P
Sbjct: 132 GHRNVVYAIAFNNPYGDK-IATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQST 190
Query: 137 LALSVGTDKTLRTWNLVEGRSAF-IKNIKQNAHIVEWSPRGEQYVV-IIQNKIDIYQLDT 194
L + D T + W++ G + ++ + ++ G++ + + + ++ DT
Sbjct: 191 LVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADT 250
Query: 195 A-SISGTITNEKRISSVKFLSESVLAVAGD-EEVIRFFDCDSLVCLCEFKAHENRVKD-M 251
++ I + ISS F + L + G ++ + +D + C+ H++ + D
Sbjct: 251 GRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSC 310
Query: 252 FSFEIPEHHVIVSASSDGFIKMW 274
F + +I +AS+DG +++
Sbjct: 311 FDY---TGKLIATASADGTARIF 330
Score = 62.0 bits (149), Expect = 9e-10
Identities = 53/247 (21%), Positives = 110/247 (44%), Gaps = 12/247 (4%)
Query: 37 THHAHTASLSAVAVNSRF---VVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGN 93
T H + A+A N+ + + TGS D+T ++ ++ + H+ I CL F
Sbjct: 129 TLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQ 188
Query: 94 RHLIS-GAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNL 152
L++ G+ D +WD + E + +++ H ++ LS + SG ++ D T+ W+
Sbjct: 189 STLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDA 248
Query: 153 VEGRSAFIKNIKQNAHIVEWSPRGEQYVVI---IQNKIDIYQLDTASISGTIT--NEKRI 207
GR I I A I S + +++ + ++ T+T +++ +
Sbjct: 249 DTGRKVNIL-IGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEIL 307
Query: 208 SSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHVIVSASS 267
S + ++A A + R F + C+ + + HE + + SF P+ + +++ SS
Sbjct: 308 DSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKI-SFN-PQGNHLLTGSS 365
Query: 268 DGFIKMW 274
D ++W
Sbjct: 366 DKTARIW 372
Score = 55.8 bits (133), Expect = 6e-08
Identities = 32/120 (26%), Positives = 61/120 (50%), Gaps = 5/120 (4%)
Query: 41 HTASLSAVAVN--SRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTI--TCLKFYGNRHL 96
H A +S+ + N ++TGS D+T ++D L H I +C + G + +
Sbjct: 260 HCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTG-KLI 318
Query: 97 ISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGR 156
+ + DG I+ A +C+ ++ H+G+++ +S +P G L+ +DKT R W+ G+
Sbjct: 319 ATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQ 378
Score = 54.7 bits (130), Expect = 1e-07
Identities = 33/120 (27%), Positives = 54/120 (45%), Gaps = 3/120 (2%)
Query: 33 VADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKF-- 90
VA T H S + + T S D T I+ + L H G I+ + F
Sbjct: 296 VATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNP 355
Query: 91 YGNRHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTW 150
GN HL++G+ D IWDA+ +CL+ ++ H ++ + + G + ++ D T R W
Sbjct: 356 QGN-HLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
>gi|66932902 SREBF chaperone protein [Homo sapiens]
Length = 1279
Score = 62.8 bits (151), Expect = 5e-10
Identities = 39/128 (30%), Positives = 61/128 (47%), Gaps = 5/128 (3%)
Query: 31 TLVADFTHH---AHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITC 87
T+ TH AH ++A+ + +VTGS+D T+ ++ ++ L HSG IT
Sbjct: 1065 TVACHLTHTVPCAHQKPITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITT 1124
Query: 88 LKFYGNRHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTL 147
+ L SG +DG IC+WD + + AH+G VT L+ S +S G D +
Sbjct: 1125 VYIDQTMVLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTTS--CVISSGLDDLI 1182
Query: 148 RTWNLVEG 155
W+ G
Sbjct: 1183 SIWDRSTG 1190
Score = 30.0 bits (66), Expect = 3.8
Identities = 16/80 (20%), Positives = 37/80 (46%), Gaps = 1/80 (1%)
Query: 40 AHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISG 99
AH ++++ + V++ D+ I I+D I+ ++ G L + L++G
Sbjct: 1158 AHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLGVISDNLLVTG 1217
Query: 100 AEDGLICIWDAKKWECLKSI 119
+ G + WD + L+++
Sbjct: 1218 GQ-GCVSFWDLNYGDLLQTV 1236
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 62.4 bits (150), Expect = 7e-10
Identities = 31/118 (26%), Positives = 57/118 (48%), Gaps = 1/118 (0%)
Query: 39 HAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGN-RHLI 97
HA+ ++ S + +GS D T ++ + H + C+KF+ N +L
Sbjct: 383 HAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLA 442
Query: 98 SGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEG 155
+G+ D + +W A++ ++ H+G V L+ P+GK S G D+ L+ W+L G
Sbjct: 443 TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASG 500
Score = 58.5 bits (140), Expect = 1e-08
Identities = 35/140 (25%), Positives = 61/140 (43%), Gaps = 10/140 (7%)
Query: 23 ACGDHEQWTLVADFT-------HHAHTASLSAVAV--NSRFVVTGSKDETIHIYDMKKKI 73
A G H++ + F + H A + V NS ++ TGS D+T+ ++ ++
Sbjct: 400 ASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGN 459
Query: 74 EHGALVHHSGTITCLKFYGN-RHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIH 132
H G + L F N ++L S ED + +WD K ++ H +T L+
Sbjct: 460 SVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFS 519
Query: 133 PSGKLALSVGTDKTLRTWNL 152
P L S D ++R W++
Sbjct: 520 PDSGLIASASMDNSVRVWDI 539
Score = 43.5 bits (101), Expect = 3e-04
Identities = 37/185 (20%), Positives = 71/185 (38%), Gaps = 44/185 (23%)
Query: 95 HLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVE 154
+ SG+ D +W + L+ H V + HP+ + TDKT+R W+ +
Sbjct: 398 YFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQ 457
Query: 155 GRSAFIKNIKQNAHI-VEWSPRGEQYVVIIQNKIDIYQLDTASISGTITNEKRISSVKFL 213
G S + + + + +SP G+
Sbjct: 458 GNSVRLFTGHRGPVLSLAFSPNGK------------------------------------ 481
Query: 214 SESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDM-FSFEIPEHHVIVSASSDGFIK 272
LA AG+++ ++ +D S E + H + + + FS P+ +I SAS D ++
Sbjct: 482 ---YLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFS---PDSGLIASASMDNSVR 535
Query: 273 MWKLK 277
+W ++
Sbjct: 536 VWDIR 540
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 62.0 bits (149), Expect = 9e-10
Identities = 29/98 (29%), Positives = 57/98 (58%), Gaps = 1/98 (1%)
Query: 54 FVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFY-GNRHLISGAEDGLICIWDAKK 112
F+++GS+D+TI ++D+ + LV H + + F+ G + ++S A+D + +WD K
Sbjct: 310 FLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKN 369
Query: 113 WECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTW 150
C+K++ AH+ VT L H + ++ D+T++ W
Sbjct: 370 KRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
Score = 56.2 bits (134), Expect = 5e-08
Identities = 49/253 (19%), Positives = 105/253 (41%), Gaps = 31/253 (12%)
Query: 55 VVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKF-YGNRHLISGAEDGLICIWDAKKW 113
+V+ S+D TI ++D + L H+ ++ + F + + L S + D I +WD + +
Sbjct: 123 MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGF 182
Query: 114 ECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWS 173
EC++++ H V+ ++I P+G +S DKT++ W + G +K + V
Sbjct: 183 ECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYC--VKTFTGHREWVRMV 240
Query: 174 PRGEQYVVII----QNKIDIYQLDTASISGTITNEKRI---------SSVKFLSESV--- 217
+ +I + ++ + T + + + SS +SE+
Sbjct: 241 RPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSE 300
Query: 218 ----------LAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHVIVSASS 267
L ++ I+ +D + +CL H+N V+ + I+S +
Sbjct: 301 TKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHS--GGKFILSCAD 358
Query: 268 DGFIKMWKLKQDK 280
D +++W K +
Sbjct: 359 DKTLRVWDYKNKR 371
Score = 52.8 bits (125), Expect = 5e-07
Identities = 37/159 (23%), Positives = 59/159 (37%), Gaps = 23/159 (14%)
Query: 33 VADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYG 92
V FT H + + + + S D+T+ ++ + K L H + C+ +
Sbjct: 227 VKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAP 286
Query: 93 NRH---------------------LISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSI 131
L+SG+ D I +WD CL ++ H V +
Sbjct: 287 ESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLF 346
Query: 132 HPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIV 170
H GK LS DKTLR W+ R +K + + H V
Sbjct: 347 HSGGKFILSCADDKTLRVWDYKNKRC--MKTLNAHEHFV 383
Score = 32.3 bits (72), Expect = 0.76
Identities = 14/60 (23%), Positives = 34/60 (56%), Gaps = 1/60 (1%)
Query: 53 RFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNR-HLISGAEDGLICIWDAK 111
+F+++ + D+T+ ++D K K L H +T L F+ ++++G+ D + +W+ +
Sbjct: 351 KFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 61.2 bits (147), Expect = 2e-09
Identities = 57/247 (23%), Positives = 108/247 (43%), Gaps = 30/247 (12%)
Query: 47 AVAVNSRFVVTGSKDETIHIYDMKKKIEH----GALVHHSGTITCLKFYGNRHLISGAED 102
A A + +V G D IY++K + + L H+G ++C +F + +++ + D
Sbjct: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGD 163
Query: 103 GLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEG--RSAFI 160
+WD + + + H G V LS+ P +L +S D + + W++ EG R F
Sbjct: 164 TTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFT 223
Query: 161 KNIKQNAHIVEWSPRGEQYVV--------IIQNKIDIYQLDTASISGTITNEKRISSVKF 212
+ + + + + + P G + + + D +L T S I I+SV F
Sbjct: 224 GH-ESDINAICFFPNGNAFATGSDDATCRLFDLRAD-QELMTYSHDNIICG---ITSVSF 278
Query: 213 LSESVLAVAGDEEVIRFFDCDSLVCLCEFKA-----HENRVKDMFSFEIPEHHVIVSASS 267
L +AG ++ F+C+ L +A H+NRV + + + + + S
Sbjct: 279 SKSGRLLLAGYDD----FNCNVWDALKADRAGVLAGHDNRVSCLGVTD--DGMAVATGSW 332
Query: 268 DGFIKMW 274
D F+K+W
Sbjct: 333 DSFLKIW 339
Score = 38.1 bits (87), Expect = 0.014
Identities = 37/197 (18%), Positives = 81/197 (41%), Gaps = 9/197 (4%)
Query: 93 NRHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNL 152
+R L+S ++DG + IWD+ + +I V + PSG G D +NL
Sbjct: 67 SRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNL 126
Query: 153 V--EGRSAFIKNIKQNAHIVEWSPRGEQYVVIIQN---KIDIYQLDTASISGTITNEK-R 206
EG + + + + + ++ + ++ ++T + T T
Sbjct: 127 KTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGD 186
Query: 207 ISSVKFLSESVLAVAGD-EEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHVIVSA 265
+ S+ ++ L V+G + + +D +C F HE+ + + F P + +
Sbjct: 187 VMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFF--PNGNAFATG 244
Query: 266 SSDGFIKMWKLKQDKKV 282
S D +++ L+ D+++
Sbjct: 245 SDDATCRLFDLRADQEL 261
Score = 36.6 bits (83), Expect = 0.040
Identities = 30/140 (21%), Positives = 62/140 (44%), Gaps = 5/140 (3%)
Query: 23 ACGDHEQWTLVADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHS 82
A D E FT H ++A ++R V+G+ D + ++D+++ + H
Sbjct: 167 ALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHE 226
Query: 83 GTITCLKFYGNRH-LISGAEDGLICIWDAKKWECLKSIKAHKG---QVTFLSIHPSGKLA 138
I + F+ N + +G++D ++D + + L + +H +T +S SG+L
Sbjct: 227 SDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICGITSVSFSKSGRLL 285
Query: 139 LSVGTDKTLRTWNLVEGRSA 158
L+ D W+ ++ A
Sbjct: 286 LAGYDDFNCNVWDALKADRA 305
>gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)
[Homo sapiens]
Length = 906
Score = 61.2 bits (147), Expect = 2e-09
Identities = 34/129 (26%), Positives = 63/129 (48%), Gaps = 6/129 (4%)
Query: 28 EQWTLVADFTHHAHTASLSAVAV--NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTI 85
++W+ F H H + N++F + S D TI ++ + + L H +
Sbjct: 130 KKWSCSQVFEGHTHYVMQIVINPKDNNQFA-SASLDRTIKVWQLGSSSPNFTLEGHEKGV 188
Query: 86 TCLKFYGNR---HLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVG 142
C+ +Y +LISGA+D L+ IWD + C+++++ H V+ S HP + ++
Sbjct: 189 NCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGS 248
Query: 143 TDKTLRTWN 151
D T+R W+
Sbjct: 249 EDGTVRIWH 257
Score = 56.6 bits (135), Expect = 4e-08
Identities = 40/204 (19%), Positives = 95/204 (46%), Gaps = 21/204 (10%)
Query: 85 ITCLKFYGNRH-LISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGT 143
+ KF ++ +++GA+D I +++ E + +AH + +++HP+ L+
Sbjct: 60 VRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSD 119
Query: 144 DKTLRTWN---------LVEGRSAFIKNIKQNAHIVEWSPRGEQYVVIIQNKIDIYQLDT 194
D ++ W+ + EG + ++ I ++ + + I ++QL +
Sbjct: 120 DMLIKLWDWDKKWSCSQVFEGHTHYVMQI-----VINPKDNNQFASASLDRTIKVWQLGS 174
Query: 195 ASISGTIT-NEKRISSVKFLS---ESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKD 250
+S + T+ +EK ++ + + S + L D+ +++ +D + C+ + H V
Sbjct: 175 SSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNV-S 233
Query: 251 MFSFEIPEHHVIVSASSDGFIKMW 274
SF PE +I++ S DG +++W
Sbjct: 234 CASFH-PELPIIITGSEDGTVRIW 256
Score = 37.4 bits (85), Expect = 0.024
Identities = 20/84 (23%), Positives = 42/84 (50%), Gaps = 5/84 (5%)
Query: 35 DFTHHAHTASLSAVAVNSR----FVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKF 90
+FT H ++ + S ++++G+ D + I+D + K L H+ ++C F
Sbjct: 178 NFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASF 237
Query: 91 YGNRHLI-SGAEDGLICIWDAKKW 113
+ +I +G+EDG + IW + +
Sbjct: 238 HPELPIIITGSEDGTVRIWHSSTY 261
Score = 29.6 bits (65), Expect = 4.9
Identities = 18/83 (21%), Positives = 36/83 (43%), Gaps = 1/83 (1%)
Query: 26 DHEQWTLVADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTI 85
D++ T V HA S ++ ++TGS+D T+ I+ L + +
Sbjct: 215 DYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERV 274
Query: 86 TCL-KFYGNRHLISGAEDGLICI 107
C+ G+ ++ G ++G I +
Sbjct: 275 WCVASLRGSNNVALGYDEGSIIV 297
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 60.8 bits (146), Expect = 2e-09
Identities = 52/255 (20%), Positives = 111/255 (43%), Gaps = 15/255 (5%)
Query: 36 FTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRH 95
F H + SA + + + ++TGS+D ++ ++ + L H+G + +F + H
Sbjct: 17 FGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGH 76
Query: 96 LISGAE-DGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVE 154
L + A D + +WD + +CL+ +K H+ V +S P + S G DK + W++
Sbjct: 77 LFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQS 136
Query: 155 GRSAFIKNIKQNAHIVEWSPRGEQYVVIIQNKID--IYQLDTASISGTITNE------KR 206
G+ ++ + + ++ S + D ++ D ++ ++++
Sbjct: 137 GQ--MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSAN 194
Query: 207 ISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDM-FSFEIPEHHVIVSA 265
IS + + + +LA ++ I + + L + K H VK + FS P+ + SA
Sbjct: 195 ISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFS---PDELWLASA 251
Query: 266 SSDGFIKMWKLKQDK 280
+K+W K
Sbjct: 252 GYSRMVKVWDCNTGK 266
Score = 60.5 bits (145), Expect = 3e-09
Identities = 37/127 (29%), Positives = 60/127 (47%), Gaps = 4/127 (3%)
Query: 55 VVTGSKDETIHIYDMKK---KIEHGALVHHSGTITCLKFYGNRHLISGAEDGLICIWDAK 111
+ TGS D T+HI+D++ + H AL HS I+CL + + L SG+ D I IW
Sbjct: 162 LATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPT 221
Query: 112 KWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRS-AFIKNIKQNAHIV 170
L +K H V ++ P S G + ++ W+ G+ +K + AH
Sbjct: 222 TSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTC 281
Query: 171 EWSPRGE 177
++P G+
Sbjct: 282 AFTPDGK 288
Score = 43.5 bits (101), Expect = 3e-04
Identities = 30/113 (26%), Positives = 53/113 (46%), Gaps = 8/113 (7%)
Query: 41 HTASLSAVAVN-SRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYG----NRH 95
H+A++S + + S + +GS D+TIHI+ K L+ G +T +K
Sbjct: 191 HSANISCLCYSASGLLASGSWDKTIHIW---KPTTSSLLIQLKGHVTWVKSIAFSPDELW 247
Query: 96 LISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLR 148
L S ++ +WD +CL+++K + P GK+ +S D+T R
Sbjct: 248 LASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 58.9 bits (141), Expect = 8e-09
Identities = 35/120 (29%), Positives = 53/120 (44%), Gaps = 1/120 (0%)
Query: 36 FTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGN-R 94
F H + + NS +V TGS D T+ ++D+ H G I L F N R
Sbjct: 623 FAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGR 682
Query: 95 HLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVE 154
L +GA DG + +WD + +K H V L G++ S D T+R W+ ++
Sbjct: 683 FLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIK 742
Score = 47.8 bits (112), Expect = 2e-05
Identities = 30/93 (32%), Positives = 41/93 (44%), Gaps = 1/93 (1%)
Query: 59 SKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNR-HLISGAEDGLICIWDAKKWECLK 117
S D I D K E L HSG + F +R +L+S +EDG + +W + + CL
Sbjct: 520 SDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLV 579
Query: 118 SIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTW 150
K H V P G +S G D+ R W
Sbjct: 580 GYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLW 612
Score = 47.8 bits (112), Expect = 2e-05
Identities = 22/103 (21%), Positives = 45/103 (43%), Gaps = 1/103 (0%)
Query: 54 FVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLIS-GAEDGLICIWDAKK 112
+ V+G D ++ H + C +F+ N + ++ G+ D + +WD
Sbjct: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN 658
Query: 113 WECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEG 155
C++ HKG + L+ P+G+ + TD + W++ G
Sbjct: 659 GNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHG 701
Score = 35.8 bits (81), Expect = 0.068
Identities = 54/248 (21%), Positives = 98/248 (39%), Gaps = 38/248 (15%)
Query: 45 LSAVAV--NSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGAED 102
L+AV V +S + G D T+ ++ + K + +K + LI D
Sbjct: 473 LTAVDVTDDSSLIAGGFADSTVRVWSVTPK-----------KLRSVKQASDLSLIDKESD 521
Query: 103 GLI-CIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIK 161
++ I D K LK + H G V S P LS D T+R W+L F
Sbjct: 522 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL----QTFTC 577
Query: 162 NIKQNAH-----IVEWSPRGEQYVVIIQNKI------DIYQLDTASISGTITNEKRISSV 210
+ H ++SP G +V +++ D YQ +G + + ++
Sbjct: 578 LVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQ-PLRIFAGHLAD---VNCT 633
Query: 211 KFLSES-VLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDM-FSFEIPEHHVIVSASSD 268
+F S +A + +R +D + C+ F H+ + + FS P + + ++D
Sbjct: 634 RFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFS---PNGRFLATGATD 690
Query: 269 GFIKMWKL 276
G + +W +
Sbjct: 691 GRVLLWDI 698
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,306,649
Number of Sequences: 37866
Number of extensions: 684613
Number of successful extensions: 5165
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 199
Number of HSP's successfully gapped in prelim test: 181
Number of HSP's that attempted gapping in prelim test: 3175
Number of HSP's gapped (non-prelim): 1517
length of query: 392
length of database: 18,247,518
effective HSP length: 104
effective length of query: 288
effective length of database: 14,309,454
effective search space: 4121122752
effective search space used: 4121122752
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.