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Search of human proteins with 55749589
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55749589 solute carrier family 6, member 16 [Homo sapiens]
(736 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55749589 solute carrier family 6, member 16 [Homo sapiens] 1491 0.0
gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo s... 448 e-126
gi|58219014 solute carrier family 6, member 17 [Homo sapiens] 448 e-126
gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo ... 399 e-111
gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo s... 365 e-100
gi|51468073 solute carrier family 6, member 19 [Homo sapiens] 360 3e-99
gi|194018524 solute carrier family 6, member 18 [Homo sapiens] 327 2e-89
gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo s... 324 2e-88
gi|6005715 solute carrier family 6 (amino acid transporter), mem... 242 8e-64
gi|4557046 solute carrier family 6 member 2 [Homo sapiens] 235 1e-61
gi|92859670 solute carrier family 6 (neurotransmitter transporte... 228 2e-59
gi|4507043 solute carrier family 6 member 4 [Homo sapiens] 226 6e-59
gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo sap... 223 4e-58
gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo sap... 223 4e-58
gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo sap... 223 4e-58
gi|188528618 solute carrier family 6 (neurotransmitter transport... 222 8e-58
gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo sapi... 211 2e-54
gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo s... 202 9e-52
gi|7657587 solute carrier family 6 (neurotransmitter transporter... 199 6e-51
gi|21361581 solute carrier family 6 (neurotransmitter transporte... 188 1e-47
gi|197276623 solute carrier family 6 (neurotransmitter transport... 171 3e-42
gi|54607094 solute carrier family 6 (neurotransmitter transporte... 171 3e-42
gi|171184408 solute carrier family 6 (neurotransmitter transport... 166 5e-41
gi|171184406 solute carrier family 6 (neurotransmitter transport... 166 5e-41
gi|171184404 solute carrier family 6 (neurotransmitter transport... 166 5e-41
gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo sa... 164 2e-40
gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo sa... 164 3e-40
gi|4507041 solute carrier family 6 (neurotransmitter transporter... 163 5e-40
gi|134304856 solute carrier family 6, member 7 [Homo sapiens] 157 3e-38
gi|197276625 solute carrier family 6 (neurotransmitter transport... 105 2e-22
>gi|55749589 solute carrier family 6, member 16 [Homo sapiens]
Length = 736
Score = 1491 bits (3860), Expect = 0.0
Identities = 736/736 (100%), Positives = 736/736 (100%)
Query: 1 MKTEAQPSTSLLANTSWTGTVISDSVPGSQTWEDKGSLTRSATSWTSEAQVSAARVAEAQ 60
MKTEAQPSTSLLANTSWTGTVISDSVPGSQTWEDKGSLTRSATSWTSEAQVSAARVAEAQ
Sbjct: 1 MKTEAQPSTSLLANTSWTGTVISDSVPGSQTWEDKGSLTRSATSWTSEAQVSAARVAEAQ 60
Query: 61 ARTSQPKQISVLEALTASALNQKPTHEKVQMTEKKESEVLLARPFWSSKTEYILAQVGFS 120
ARTSQPKQISVLEALTASALNQKPTHEKVQMTEKKESEVLLARPFWSSKTEYILAQVGFS
Sbjct: 61 ARTSQPKQISVLEALTASALNQKPTHEKVQMTEKKESEVLLARPFWSSKTEYILAQVGFS 120
Query: 121 MKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPLLFLEMAAGQSMRQGGMGVWKIIAP 180
MKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPLLFLEMAAGQSMRQGGMGVWKIIAP
Sbjct: 121 MKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPLLFLEMAAGQSMRQGGMGVWKIIAP 180
Query: 181 WIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPWEKCPLTMNSSGFDPECERT 240
WIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPWEKCPLTMNSSGFDPECERT
Sbjct: 181 WIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPWEKCPLTMNSSGFDPECERT 240
Query: 241 TPSIYFWYQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLL 300
TPSIYFWYQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLL
Sbjct: 241 TPSIYFWYQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLL 300
Query: 301 PCFIIVGFFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASL 360
PCFIIVGFFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASL
Sbjct: 301 PCFIIVGFFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASL 360
Query: 361 ASYMPQSNNCLSDAFLVSVINLLTLLVFTSFNFCVLGFWATVITHRCCERNAEILLKLIN 420
ASYMPQSNNCLSDAFLVSVINLLTLLVFTSFNFCVLGFWATVITHRCCERNAEILLKLIN
Sbjct: 361 ASYMPQSNNCLSDAFLVSVINLLTLLVFTSFNFCVLGFWATVITHRCCERNAEILLKLIN 420
Query: 421 LGKLPPDAKPPVNLLYNPTSIYNAWLSGLPQHIKSMVLREVTECNIETQFLKASEGPKFA 480
LGKLPPDAKPPVNLLYNPTSIYNAWLSGLPQHIKSMVLREVTECNIETQFLKASEGPKFA
Sbjct: 421 LGKLPPDAKPPVNLLYNPTSIYNAWLSGLPQHIKSMVLREVTECNIETQFLKASEGPKFA 480
Query: 481 FLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGIITPLQDTFSFFRKHTKLLIV 540
FLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGIITPLQDTFSFFRKHTKLLIV
Sbjct: 481 FLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGIITPLQDTFSFFRKHTKLLIV 540
Query: 541 GVFLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIVVVVFETMAVSWAYGARRFLADLTI 600
GVFLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIVVVVFETMAVSWAYGARRFLADLTI
Sbjct: 541 GVFLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIVVVVFETMAVSWAYGARRFLADLTI 600
Query: 601 LLGHPISPIFGWLWPHLCPVVLLIIFVTMMVHLCMKPITYMSWDSSTSKEVLRPYPPWAL 660
LLGHPISPIFGWLWPHLCPVVLLIIFVTMMVHLCMKPITYMSWDSSTSKEVLRPYPPWAL
Sbjct: 601 LLGHPISPIFGWLWPHLCPVVLLIIFVTMMVHLCMKPITYMSWDSSTSKEVLRPYPPWAL 660
Query: 661 LLMITLFAIVILPIPAYFVYCRIHRIPFRPKSGDGPMTASTSLPLSHQLTPSKEVQKEEI 720
LLMITLFAIVILPIPAYFVYCRIHRIPFRPKSGDGPMTASTSLPLSHQLTPSKEVQKEEI
Sbjct: 661 LLMITLFAIVILPIPAYFVYCRIHRIPFRPKSGDGPMTASTSLPLSHQLTPSKEVQKEEI 720
Query: 721 LQVDETKYPSTCNVTS 736
LQVDETKYPSTCNVTS
Sbjct: 721 LQVDETKYPSTCNVTS 736
>gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo
sapiens]
Length = 730
Score = 448 bits (1153), Expect = e-126
Identities = 223/594 (37%), Positives = 350/594 (58%), Gaps = 7/594 (1%)
Query: 97 SEVLLARPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPL 156
SEV RP W+SK +YILAQVGFS+ +WRF YL +GG ++ Y+ +L ++G+PL
Sbjct: 55 SEVEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPL 114
Query: 157 LFLEMAAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQ 216
FLE++ GQ +R+G +GVW I+P +GG+G++S +VC+ + LY+NV+ W +FY SQSFQ
Sbjct: 115 FFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQ 174
Query: 217 FPVPWEKCPLTMNSSG--FDPECERTTPSIYFWYQQALKASDRIEDGGSPVYSLVLPFFL 274
P+PW++CPL N+S +PECE+++ + Y+WY++AL S I + G + + +
Sbjct: 175 QPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLA 234
Query: 275 CWCLVGAFMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAKFGLQQLVVAKISDVY 334
W +V MI G++S+GK+IY L P +++ F IR LL G+ G++ + K+ +
Sbjct: 235 AWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIML 294
Query: 335 NMSVWSLAGGQVLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSVINLLTLLVFTSFNFC 394
VW A QV G+G G V + +SY + NNC DA LVS IN T ++ T F
Sbjct: 295 EPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFA 354
Query: 395 VLGFWATVITHRCCERNAEILLKLINLGKLPPDAKPPVNLLYNPTSIYNAWLSGLPQHIK 454
VLGF A VI +C +N+E ++K + +G + D P L T+ + + Q +K
Sbjct: 355 VLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVYDIIQKVK 414
Query: 455 --SMVLREVTECNIETQFLKASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSS 512
+ C IE + KA +G AF++F EAM+ P S FWS +FFLML+ +GL S
Sbjct: 415 EEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGS 474
Query: 513 AIGIMQGIITPLQDTFSFFRKHTKLLIVGVFLLMFVCGLFFTRPSGSYFIRLLSDYWIVF 572
G ++GI+TP+ DT F+ ++L V LL F GL F + SG+YF+ + DY
Sbjct: 475 MFGTIEGIVTPIVDT---FKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATL 531
Query: 573 PIIVVVVFETMAVSWAYGARRFLADLTILLGHPISPIFGWLWPHLCPVVLLIIFVTMMVH 632
P+++VV+ E +AV + YG +F+ DL +LG S + ++W ++ P++LL + + +V+
Sbjct: 532 PLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVN 591
Query: 633 LCMKPITYMSWDSSTSKEVLRPYPPWALLLMITLFAIVILPIPAYFVYCRIHRI 686
+ + P Y +W + E YP W L++ ++L ILP+P F+ R + I
Sbjct: 592 MGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLI 645
>gi|58219014 solute carrier family 6, member 17 [Homo sapiens]
Length = 727
Score = 448 bits (1152), Expect = e-126
Identities = 237/668 (35%), Positives = 368/668 (55%), Gaps = 28/668 (4%)
Query: 70 SVLEALTASALNQKPTHEKVQMTEKKESEVLLARPFWSSKTEYILAQVGFSMKPSCLWRF 129
SVL + QK E++ + RP W+SK +YILAQ+GFS+ +WRF
Sbjct: 36 SVLNVAGEAGGKQKAVEEELDAED---------RPAWNSKLQYILAQIGFSVGLGNIWRF 86
Query: 130 AYLWLNSGGCSFAAIYIFMLFLVGVPLLFLEMAAGQSMRQGGMGVWKIIAPWIGGVGYSS 189
YL +GG ++ Y+ +L ++G+PL FLE+A GQ +R+G +GVW I P +GG+G+SS
Sbjct: 87 PYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSS 146
Query: 190 FMVCFILGLYFNVVNSWIIFYMSQSFQFPVPWEKCPLTMNSS--GFDPECERTTPSIYFW 247
+VC +GLY+NV+ W IFY +SFQ+P+PW +CP+ N S + ECE+++ + YFW
Sbjct: 147 CIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWSECPVVRNGSVAVVEAECEKSSATTYFW 206
Query: 248 YQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLLPCFIIVG 307
Y++AL SD I + G + + L + W +VG ++ G++S+GKV+Y L P ++
Sbjct: 207 YREALDISDSISESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLAC 266
Query: 308 FFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASLASYMPQS 367
F +R LLL GA G+ + K+ + + VW A QV G+G G V + +SY Q
Sbjct: 267 FLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQD 326
Query: 368 NNCLSDAFLVSVINLLTLLVFTSFNFCVLGFWATVITHRCCERNAEILLKLINLGKLPPD 427
NNC DA LVS IN T ++ T F VLGF A ++ +C NAE +L +N L D
Sbjct: 327 NNCHFDAALVSFINFFTSVLATLVVFAVLGFKANIMNEKCVVENAEKILGYLNTNVLSRD 386
Query: 428 AKPP-VNLLYNPT----SIYNAWLSGLPQHIKSMVLREVTECNIETQFLKASEGPKFAFL 482
PP VN + T +YN ++ ++ L C +E + K+ +G AF+
Sbjct: 387 LIPPHVNFSHLTTKDYMEMYNVIMTVKEDQFSALGL---DPCLLEDELDKSVQGTGLAFI 443
Query: 483 SFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGIITPLQDTFSFFRKHTKLLIVGV 542
+F EAM+ P S FWS +FFLML+ +GL S IG M GI TP+ DT F+ ++ VG
Sbjct: 444 AFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDT---FKVPKEMFTVGC 500
Query: 543 FLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIVVVVFETMAVSWAYGARRFLADLTILL 602
+ F+ GL F + SG+YF+ + DY P+ ++V+ E +AV+W YG ++F+ +LT +L
Sbjct: 501 CVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILENIAVAWIYGTKKFMQELTEML 560
Query: 603 GHPISPIFGWLWPHLCPVVLLIIFVTMMVHLCMKPITYMSWDSSTSKEVLRPYPPWALLL 662
G + ++W + P+ + ++ ++ L + P Y +W + E +P WA+ L
Sbjct: 561 GFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSAWIKEEAAERYLYFPNWAMAL 620
Query: 663 MITLFAIVILPIPAYFVYCRIHRIPFRPKSGDGPMTASTSLPLSHQLTPSKEVQKEEILQ 722
+ITL + LPIP FV H + DG T S S + +++ + +
Sbjct: 621 LITLIVVATLPIPVVFVLRHFHLL------SDGSNTLSVSYKKGRMMKDISNLEENDETR 674
Query: 723 VDETKYPS 730
+K PS
Sbjct: 675 FILSKVPS 682
>gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo
sapiens]
Length = 623
Score = 399 bits (1026), Expect = e-111
Identities = 197/540 (36%), Positives = 315/540 (58%), Gaps = 7/540 (1%)
Query: 151 LVGVPLLFLEMAAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFY 210
++G+PL FLE++ GQ +R+G +GVW I+P +GG+G++S +VC+ + LY+NV+ W +FY
Sbjct: 2 VIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFY 61
Query: 211 MSQSFQFPVPWEKCPLTMNSSG--FDPECERTTPSIYFWYQQALKASDRIEDGGSPVYSL 268
SQSFQ P+PW++CPL N+S +PECE+++ + Y+WY++AL S I + G + +
Sbjct: 62 FSQSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKM 121
Query: 269 VLPFFLCWCLVGAFMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAKFGLQQLVVA 328
+ W +V MI G++S+GK+IY L P +++ F IR LL G+ G++ +
Sbjct: 122 TICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTP 181
Query: 329 KISDVYNMSVWSLAGGQVLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSVINLLTLLVF 388
K+ + VW A QV G+G G V + +SY + NNC DA LVS IN T ++
Sbjct: 182 KLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLA 241
Query: 389 TSFNFCVLGFWATVITHRCCERNAEILLKLINLGKLPPDAKPPVNLLYNPTSIYNAWLSG 448
T F VLGF A VI +C +N+E ++K + +G + D P L T+ +
Sbjct: 242 TLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVYD 301
Query: 449 LPQHIK--SMVLREVTECNIETQFLKASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLL 506
+ Q +K + C IE + KA +G AF++F EAM+ P S FWS +FFLML+
Sbjct: 302 IIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLV 361
Query: 507 AMGLSSAIGIMQGIITPLQDTFSFFRKHTKLLIVGVFLLMFVCGLFFTRPSGSYFIRLLS 566
+GL S G ++GI+TP+ DT F+ ++L V LL F GL F + SG+YF+ +
Sbjct: 362 NLGLGSMFGTIEGIVTPIVDT---FKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFD 418
Query: 567 DYWIVFPIIVVVVFETMAVSWAYGARRFLADLTILLGHPISPIFGWLWPHLCPVVLLIIF 626
DY P+++VV+ E +AV + YG +F+ DL +LG S + ++W ++ P++LL +
Sbjct: 419 DYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLL 478
Query: 627 VTMMVHLCMKPITYMSWDSSTSKEVLRPYPPWALLLMITLFAIVILPIPAYFVYCRIHRI 686
+ +V++ + P Y +W + E YP W L++ ++L ILP+P F+ R + I
Sbjct: 479 IASVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLI 538
>gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo
sapiens]
Length = 592
Score = 365 bits (936), Expect = e-100
Identities = 201/600 (33%), Positives = 322/600 (53%), Gaps = 13/600 (2%)
Query: 102 ARPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPLLFLEM 161
ARP W++ +++ A + +++ +WRF YL GG SF YI ML + G+PLL+LE+
Sbjct: 4 ARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLEL 63
Query: 162 AAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPW 221
A GQ MRQG +G W+ I+P++ GVG +S +V F L +Y+NV+N+W +Y+ SFQ P+PW
Sbjct: 64 AVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPW 123
Query: 222 EKCPLTMNSSGFDPECERTTPSIYFWYQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGA 281
CPL N +G+D ECE+ + + YFWY++ L S +++ G + L L W +V
Sbjct: 124 SVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVYL 183
Query: 282 FMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSL 341
++ G +STGKV+Y LP +++ + IR L L GA GL + KI + N W
Sbjct: 184 CILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQLANPKAWIN 243
Query: 342 AGGQVLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSVINLLTLLVFTSFNFCVLGFWAT 401
A Q+ + G+G GS+ + ASY SNNC A +VS+IN T + + F + GF AT
Sbjct: 244 AATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKAT 303
Query: 402 VITHRCCERNAEILLKLINLGKLPPDAKPPVNLLYNPTSIYNAWLSGLPQHIKSMVLREV 461
C ++ + L L N L NL + S P M ++
Sbjct: 304 FNYENCLKK---VSLLLTNTFDLEDGFLTASNL----EQVKGYLASAYPSKYSEM-FPQI 355
Query: 462 TECNIETQFLKASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGII 521
C++E++ A +G AF+ + EA+ + S WS ++F MLL +G+ S +G I+
Sbjct: 356 KNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAIL 415
Query: 522 TPLQDTFSFFRKHTKLLIVG-VFLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIVVVVF 580
TPL D+ K I G V L+ G+ FT +G+Y+ + +DY ++++V+
Sbjct: 416 TPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLV 475
Query: 581 ETMAVSWAYGARRFLADLTILLGHPISPIFGWLWPHLCPVVLLIIFVTMMV-HLCMKPIT 639
ET+AV + YG RRF +DL + G +S + +W + P++++ +FV + ++ +
Sbjct: 476 ETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLK 535
Query: 640 YMSWDSSTSKEVLRPYPPWALLLMITLFAIVILPIPAYFVYCRIHRIPFRPKSGDGPMTA 699
Y +WD+S + V + YP +AL ++ L A + IP + + R R K GD A
Sbjct: 536 YQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQR---RLKRGDADPVA 592
>gi|51468073 solute carrier family 6, member 19 [Homo sapiens]
Length = 634
Score = 360 bits (923), Expect = 3e-99
Identities = 204/621 (32%), Positives = 323/621 (52%), Gaps = 14/621 (2%)
Query: 93 EKKESEVLLARPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLV 152
E E E +RP W +K +Y+L +GF + +WRF YL + GG +F ++ +L L
Sbjct: 22 ETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLE 81
Query: 153 GVPLLFLEMAAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMS 212
G+PLL+LE A GQ +R+G +GVW I P + G+G +S + F++GLY+N + SWI++Y+
Sbjct: 82 GIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLF 141
Query: 213 QSFQFPVPWEKCPLTMNSSGFDPECERTTPSIYFWYQQALKASDRIEDGGSPVYSLVLPF 272
SFQ P+PW CPL N +G+ EC R++P YFWY++ L S I D GS + ++L
Sbjct: 142 NSFQEPLPWSDCPLNENQTGYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCL 201
Query: 273 FLCWCLVGAFMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAKFGLQQLVVAKISD 332
W ++ I G+++TGK +Y+ LP ++ F IR L L+GA G+ L +++
Sbjct: 202 ACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTE 261
Query: 333 VYNMSVWSLAGGQVLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSVINLLTLLVFTSFN 392
+ W AG QV + + G + S +SY NNC D+ +VS+IN T +
Sbjct: 262 LAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVV 321
Query: 393 FCVLGFWATVITHRCCERNAEILLKLINLGKLPPDAKPPVNLLYNPTSIYNAWLSGLPQH 452
+ V+GF AT C N +L LIN LP N + + + P
Sbjct: 322 YSVIGFRATQRYDDCFSTN---ILTLINGFDLPEGNVTQENFV----DMQQRCNASDPAA 374
Query: 453 IKSMVLREVTECNIETQFLKASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSS 512
+V + C+I +A EG AF+ F EA++ +P S WS +FF+ML +GLSS
Sbjct: 375 YAQLVFQ---TCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSS 431
Query: 513 AIGIMQGIITPLQDTFSFFRKHTKLLIVGVFLL-MFVCGLFFTRPSGSYFIRLLSDYWIV 571
G M+G++ PLQD K K ++ G+ L F+ G FT SG Y++ LL Y
Sbjct: 432 MFGNMEGVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGS 491
Query: 572 FPIIVVVVFETMAVSWAYGARRFLADLTILLGHPISPIFGWLWPHLCPVVLLIIFVTMMV 631
P++++ E +V + YG RF D+ ++GH + + W + P+++LIIF+ V
Sbjct: 492 IPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFV 551
Query: 632 HLCMKPITYMSWD---SSTSKEVLRPYPPWALLLMITLFAIVILPIPAYFVYCRIHRIPF 688
+ +TY WD K YP W ++++ + + L IP Y +Y I
Sbjct: 552 VEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQ 611
Query: 689 RPKSGDGPMTASTSLPLSHQL 709
+P G ++ ++ ++ L
Sbjct: 612 KPGDHQGLVSTLSTASMNGDL 632
>gi|194018524 solute carrier family 6, member 18 [Homo sapiens]
Length = 628
Score = 327 bits (838), Expect = 2e-89
Identities = 191/584 (32%), Positives = 304/584 (52%), Gaps = 29/584 (4%)
Query: 103 RPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPLLFLEMA 162
RP W +K +Y+L+ GF++ +WRF YL GG +F Y+ L G+P+ +E+A
Sbjct: 18 RPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVELA 77
Query: 163 AGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPWE 222
GQ +R+G +GVW I+P++ GVG + F++ LY+N + +W+++Y+ SFQ P+PW
Sbjct: 78 IGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPWS 137
Query: 223 KCPLTMNSSGFDPECERTTPSIYFWYQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGAF 282
CP +N +GF EC+ ++ YFWY+Q L + I D GS + L++ W +V
Sbjct: 138 SCPPDLNRTGFVEECQGSSAVSYFWYRQTLNITADINDSGSIQWWLLICLAASWAVVYMC 197
Query: 283 MINGLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSLA 342
+I G+++TGKVIY L P ++ F IR L L GA GL L + + N VW A
Sbjct: 198 VIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNMHILQNPRVWLDA 257
Query: 343 GGQVLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSVINLLTLLVFTSFNFCVLGFWATV 402
Q+ + + G + ASY N+C DA +++++N +T L + F VLGF AT
Sbjct: 258 ATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASIAVFSVLGFKATN 317
Query: 403 ITHRCCERNAEILLKLINLGKLPP-----DAKPPVNLLYNPTSIYNAWLSGLPQHIKSMV 457
C +RN +L LIN P D P V + N T W P+ + +
Sbjct: 318 DYEHCLDRN---ILSLINDFDFPEQSISRDDYPAVLMHLNAT-----W----PKRVAQLP 365
Query: 458 LREVTECNIETQFLKASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIM 517
L+ C +E K++ GP AF+ F E +P + W+ +FF ML +GLS+ G +
Sbjct: 366 LK---ACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTV 422
Query: 518 QGIITPLQDTFSFFRKHTKLLIVG-VFLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIV 576
+ +ITPL D R K + G V L+ F+ FT SG+Y++ + ++ +++
Sbjct: 423 EAVITPLLDVGVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASPNLLM 482
Query: 577 VVVFETMAVSWAYGARRFLADLTILLGHPISPIFGWLWPHLCPVVLLIIFVTMMVHLCMK 636
+ E + V + YG +RF D+ + G SP + W + P +LL IFV ++ L K
Sbjct: 483 LAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSP-LLLTIFVAYIILLFWK 541
Query: 637 PITYMSWDSS-----TSKEVLRPYPPWALLLMITLFAIVILPIP 675
P+ Y +W+ + +E L YP WA + L + +L +P
Sbjct: 542 PLRYKAWNPKYELFPSRQEKL--YPGWARAACVLLSLLPVLWVP 583
>gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo
sapiens]
Length = 555
Score = 324 bits (830), Expect = 2e-88
Identities = 188/600 (31%), Positives = 303/600 (50%), Gaps = 50/600 (8%)
Query: 102 ARPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPLLFLEM 161
ARP W++ +++ A + +++ +WRF YL GG SF YI ML + G+PLL+LE+
Sbjct: 4 ARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLEL 63
Query: 162 AAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPW 221
A GQ MRQG +G W+ I+P++ GVG +S +V F L +Y+NV+N+W +Y+ SFQ P+PW
Sbjct: 64 AVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPW 123
Query: 222 EKCPLTMNSSGFDPECERTTPSIYFWYQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGA 281
CPL N +G+D ECE+ + + YFWY++ L S +++ G + L L W +V
Sbjct: 124 SVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVYL 183
Query: 282 FMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSL 341
++ G +STG KI + N W
Sbjct: 184 CILRGTESTG-------------------------------------KIEQLANPKAWIN 206
Query: 342 AGGQVLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSVINLLTLLVFTSFNFCVLGFWAT 401
A Q+ + G+G GS+ + ASY SNNC A +VS+IN T + + F + GF AT
Sbjct: 207 AATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKAT 266
Query: 402 VITHRCCERNAEILLKLINLGKLPPDAKPPVNLLYNPTSIYNAWLSGLPQHIKSMVLREV 461
C ++ + L L N L NL + S P M ++
Sbjct: 267 FNYENCLKK---VSLLLTNTFDLEDGFLTASNL----EQVKGYLASAYPSKYSEM-FPQI 318
Query: 462 TECNIETQFLKASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGII 521
C++E++ A +G AF+ + EA+ + S WS ++F MLL +G+ S +G I+
Sbjct: 319 KNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAIL 378
Query: 522 TPLQDTFSFFRKHTKLLIVG-VFLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIVVVVF 580
TPL D+ K I G V L+ G+ FT +G+Y+ + +DY ++++V+
Sbjct: 379 TPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLV 438
Query: 581 ETMAVSWAYGARRFLADLTILLGHPISPIFGWLWPHLCPVVLLIIFVTMMV-HLCMKPIT 639
ET+AV + YG RRF +DL + G +S + +W + P++++ +FV + ++ +
Sbjct: 439 ETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLK 498
Query: 640 YMSWDSSTSKEVLRPYPPWALLLMITLFAIVILPIPAYFVYCRIHRIPFRPKSGDGPMTA 699
Y +WD+S + V + YP +AL ++ L A + IP + + R R K GD A
Sbjct: 499 YQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQR---RLKRGDADPVA 555
>gi|6005715 solute carrier family 6 (amino acid transporter), member
14 [Homo sapiens]
Length = 642
Score = 242 bits (618), Expect = 8e-64
Identities = 167/626 (26%), Positives = 274/626 (43%), Gaps = 138/626 (22%)
Query: 106 WSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPLLFLEMAAGQ 165
WS K++Y+L+ +G+++ +WRF YL ++GG +F Y ML L G+PL FLE + GQ
Sbjct: 39 WSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECSLGQ 98
Query: 166 SMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPWEKCP 225
G + VW+I+ P GVG + ++ + +Y+NV+ ++ ++YM SFQ +PW+ C
Sbjct: 99 FASLGPVSVWRIL-PLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNC- 156
Query: 226 LTMNSSGFDPECERT--------------------------------------------T 241
SS D C R+
Sbjct: 157 ----SSWSDKNCSRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSEIYQPGQL 212
Query: 242 PSIYFWYQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLLP 301
PS +W + AL+ S + + G V+ L L L W +VGA + G+KS+GKV+Y L P
Sbjct: 213 PSEQYWNKVALQRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFP 272
Query: 302 CFIIVGFFIRTLLLEGAKFGLQQLVVAK--ISDVYNMSVWSLAGGQVLSNTGIGLGSVAS 359
+++ +R LEGA G+ + A+ + + VW A Q+ + + G + +
Sbjct: 273 YVVLLILLVRGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAWGGLVA 332
Query: 360 LASYMPQSNNCLSDAFLVSVINLLTLLVFTSFN-FCVLGFWATVITHRCCERNAEILLKL 418
L+SY NNC SDA +V + N LT VF F F +LG A
Sbjct: 333 LSSYNKFKNNCFSDAIVVCLTNCLT-SVFAGFAIFSILGHMA------------------ 373
Query: 419 INLGKLPPDAKPPVNLLYNPTSIYNAWLSGLPQHIKSMVLREVTECNIETQFLKASEGPK 478
HI + +V + + F
Sbjct: 374 ---------------------------------HISGKEVSQVVKSGFDLAF-------- 392
Query: 479 FAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGIITPLQDTFSFFRKHTKL- 537
+++ EA++ LP FWS +FF MLL +GL S ++ I T +QD F K ++
Sbjct: 393 ---IAYPEALAQLPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFPKVMKKMRVP 449
Query: 538 LIVGVFLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIVVVVFETMAVSWAYGARRFLAD 597
+ +G L++F+ GL +G Y++ L+ + + I++ + E + + W YG RF+ D
Sbjct: 450 ITLGCCLVLFLLGLVCVTQAGIYWVHLIDHFCAGWGILIAAILELVGIIWIYGGNRFIED 509
Query: 598 LTILLGHPISPIFGWLWPHLC-----PVVLLIIFVTMMVHLCMKPITYMSWDSSTSKEVL 652
+++G WLW C P++L+ IF+ +V +
Sbjct: 510 TEMMIG--AKRWIFWLWWRACWFVITPILLIAIFIWSLVQFHRPNYGAI----------- 556
Query: 653 RPYPPWALLL--MITLFAIVILPIPA 676
PYP W + L + +F I+ +PI A
Sbjct: 557 -PYPDWGVALGWCMIVFCIIWIPIMA 581
>gi|4557046 solute carrier family 6 member 2 [Homo sapiens]
Length = 617
Score = 235 bits (599), Expect = 1e-61
Identities = 173/628 (27%), Positives = 281/628 (44%), Gaps = 104/628 (16%)
Query: 80 LNQKPTHEKVQMTEKKESEVLLA--------RPFWSSKTEYILAQVGFSMKPSCLWRFAY 131
L + T E + + E+ + LLA R W K +++L+ VGF++ + +WRF Y
Sbjct: 25 LRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPY 84
Query: 132 LWLNSGGCSFAAIYIFMLFLVGVPLLFLEMAAGQSMRQGGMGVWKIIAPWIGGVGYSSFM 191
L +GG +F Y L + G+PL ++E+A GQ R+G VWKI P+ GVGY+ +
Sbjct: 85 LCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKI-CPFFKGVGYAVIL 143
Query: 192 VCFILGLYFNVVNSWIIFYMSQSFQFPVPWEKCPLTMNSSGF-DPEC------------- 237
+ +G Y+NV+ +W ++Y+ SF +PW C T NS DP+
Sbjct: 144 IALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYS 203
Query: 238 -ERTTPSIYFWYQQALKA--SDRIEDGGSPVYSLVLPFFLCWCLVGAFMINGLKSTGKVI 294
+ TP+ F+ + L S I D G P + L+L + ++ + G+K++GKV+
Sbjct: 204 KYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVV 263
Query: 295 YVLVLLPCFIIVGFFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSLAGGQVLSNTGIGL 354
++ LP F++ + + L GA G+ + + +VW A Q+ + G G
Sbjct: 264 WITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGF 323
Query: 355 GSVASLASYMPQSNNCLSDAFLVSVINLLTLLVFTSFNFCVLGFWATVITHRCCERNAEI 414
G L+ F S+N C R+A
Sbjct: 324 G----------------------------VLIAFASYNKF----------DNNCYRDA-- 343
Query: 415 LLKLINLGKLPPDAKPPVNLLYNPTSIYNAWLSGLPQHIKSMVLREVTECNIETQFLKAS 474
LL + + +++SG + + NIE A+
Sbjct: 344 -------------------LLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDV---AT 381
Query: 475 EGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGIITPLQDTFSFFRKH 534
EG F+ + EA+S L S FW+ +FF+MLLA+GL S++G M+ +IT L D F ++H
Sbjct: 382 EGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRH 441
Query: 535 TKLLIVGVFLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIVVVVFETMAVSWAYGARRF 594
KL GV F+ LF G Y + LL + I+ V+ E + VSW YG RF
Sbjct: 442 RKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRF 501
Query: 595 LADLTILLGHPISPIFGWLWPHLCPVVLLIIFVTMMVHLCMKPITYMSWDSSTSKEVLRP 654
D+ ++G + W + P LL + V +++ KP+TY +
Sbjct: 502 SNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIIN--FKPLTYDDY----------I 549
Query: 655 YPPWALLL--MITLFAIVILPIPAYFVY 680
+PPWA + I L ++V++PI Y +Y
Sbjct: 550 FPPWANWVGWGIALSSMVLVPI--YVIY 575
>gi|92859670 solute carrier family 6 (neurotransmitter transporter,
glycine), member 5 [Homo sapiens]
Length = 797
Score = 228 bits (580), Expect = 2e-59
Identities = 184/704 (26%), Positives = 302/704 (42%), Gaps = 147/704 (20%)
Query: 35 KGSLTRSATSWTSEAQVSAARVAEAQARTSQPKQISVLEALTASALNQKPTHEKVQMTEK 94
KG+L R+ T +S + V A + SVL A+ Q E
Sbjct: 138 KGTLERNNTPVVGWVNMSQSTVVLATDGIT-----SVLPGSVATVATQ----------ED 182
Query: 95 KESEVLLARPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGV 154
++ + AR WSSK ++IL+ VG+++ +WRF YL +GG +F Y+ ML L G+
Sbjct: 183 EQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGL 242
Query: 155 PLLFLEMAAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQS 214
P+ FLE++ GQ QG + VWK I P + G G + ++ ++ +Y+NV+ + +FY+ S
Sbjct: 243 PIFFLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYTLFYLFAS 301
Query: 215 FQFPVPWEKCPLTMNSSGFDPECERTT---------------------------PSI--- 244
F +PW C N+ PEC+ T P++
Sbjct: 302 FVSVLPWGSCNNPWNT----PECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMV 357
Query: 245 ----------------YFWYQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGAFMINGLK 288
YF Y LK S IE G + L L FL W +V A + G+K
Sbjct: 358 NFTSQANKTFVSGSEEYFKYF-VLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIK 416
Query: 289 STGKVIYVLVLLPCFIIVGFFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSLAGGQVLS 348
++GKV+Y P ++V IR + L GA G+ + K + + +VW A Q+
Sbjct: 417 TSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFF 476
Query: 349 NTGIGLGSVASLASYMPQSNNCLSDAFLVSVINLLTLLVFTSFNFCVLGFWATVITHRCC 408
+ G L+TL + F H C
Sbjct: 477 SLSAAWGG-------------------------LITLSSYNKF-------------HNNC 498
Query: 409 ERNAEILLKLINLGKLPPDAKPPVNLLYNPTSIYNAWLSGLPQHIKSMV--LREVTECNI 466
R+ I V + TSI+ ++ I S++ + + NI
Sbjct: 499 YRDTLI-----------------VTCTNSATSIFAGFV------IFSVIGFMANERKVNI 535
Query: 467 ETQFLKASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGIITPLQD 526
E A +GP AF+ + EA++ LP S FW+ IFFLMLL +GL + ++ I+T + D
Sbjct: 536 ENV---ADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISD 592
Query: 527 TF-SFFRKHTKLLIVGVFLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIVVVVFETMAV 585
F + R H + +G + F+ G G Y +L+ Y + ++++ +FE + +
Sbjct: 593 EFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGI 652
Query: 586 SWAYGARRFLADLTILLGHPISPIFGWLWPHLCPVVLLIIFVTMMVHLCMKPITYMSWDS 645
S+ YG +RF D+ +++G + + W + P +L F+ +P+TY S+
Sbjct: 653 SYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTIL--TFILCFSFYQWEPMTYGSY-- 708
Query: 646 STSKEVLRPYPPWALLLMITLFAIVILPIPAYFVYCRIHRIPFR 689
YP W+++L + A ++ IP FV ++H P R
Sbjct: 709 --------RYPNWSMVLGWLMLACSVIWIPIMFV-IKMHLAPGR 743
>gi|4507043 solute carrier family 6 member 4 [Homo sapiens]
Length = 630
Score = 226 bits (576), Expect = 6e-59
Identities = 154/591 (26%), Positives = 269/591 (45%), Gaps = 87/591 (14%)
Query: 103 RPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPLLFLEMA 162
R W K +++L+ +G+++ +WRF Y+ +GG +F Y M G+PL ++E+A
Sbjct: 79 RETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELA 138
Query: 163 AGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPWE 222
GQ R G + +W+ I P G+GY+ ++ F + Y+N + +W ++Y+ SF +PW
Sbjct: 139 LGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWT 198
Query: 223 KCPLTMNSSG----FDPE-----CERTTPSIYFWYQQALK--ASDRIEDGGSPVYSLVLP 271
C + N+ F + T+P+ F+ + L+ S ++D G + L L
Sbjct: 199 SCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALC 258
Query: 272 FFLCWCLVGAFMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAKFGLQQLVVAKIS 331
L + ++ + G+K++GKV++V P I+ +R L GA G+ +
Sbjct: 259 IMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQ 318
Query: 332 DVYNMSVWSLAGGQVLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSVINLLTLLVFTSF 391
+ VW A Q+ + G G G + + ASY +NNC DA + SV+N +T V
Sbjct: 319 KLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFV 378
Query: 392 NFCVLGFWATVITHRCCERNAEILLKLINLGKLPPDAKPPVNLLYNPTSIYNAWLSGLPQ 451
F VLG+ A + RN ++ ++ DA P +LL+
Sbjct: 379 IFTVLGYMAEM-------RNEDV-------SEVAKDAGP--SLLF--------------- 407
Query: 452 HIKSMVLREVTECNIETQFLKASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLS 511
+++ EA++ +P S F++ IFFLML+ +GL
Sbjct: 408 ------------------------------ITYAEAIANMPASTFFAIIFFLMLITLGLD 437
Query: 512 SAIGIMQGIITPLQDTF-SFFRKHTKLLIVGVFLLMFVCGLFFTRPSGSYFIRLLSDYWI 570
S ++G+IT + D F + K + ++ V + F L G+Y ++LL +Y
Sbjct: 438 STFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYAT 497
Query: 571 VFPIIVVVVFETMAVSWAYGARRFLADLTILLGHPISPIFGWLWPHLCPVVLLIIFVTMM 630
++ V + E +AVSW YG +F D+ +LG SP GW W +C V + +F+ +
Sbjct: 498 GPAVLTVALIEAVAVSWFYGITQFCRDVKEMLG--FSP--GWFW-RICWVAISPLFLLFI 552
Query: 631 V-HLCMKPITYMSWDSSTSKEVLRPYPPWALLLMITLFAIVILPIPAYFVY 680
+ M P + + YP W+++L + + IP Y Y
Sbjct: 553 ICSFLMSPPQLRLFQYN--------YPYWSIILGYCIGTSSFICIPTYIAY 595
>gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo
sapiens]
Length = 633
Score = 223 bits (569), Expect = 4e-58
Identities = 159/622 (25%), Positives = 277/622 (44%), Gaps = 107/622 (17%)
Query: 92 TEKKESEVLLARPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFL 151
+E + + L R W ++ E++L VG+++ +WRF YL +GG +F Y ML
Sbjct: 16 SEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIF 75
Query: 152 VGVPLLFLEMAAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYM 211
G+PL F+E++ GQ QG +GVW+I +P GVGY +V +G+Y+NVV +Y
Sbjct: 76 CGIPLFFMELSFGQFASQGCLGVWRI-SPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYF 134
Query: 212 SQSFQFPVPWEKCPLTMNS-------------SGFDPEC-------------ERTTPSIY 245
S +PW C N+ +G P +RT+PS
Sbjct: 135 FSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEE 194
Query: 246 FWYQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLLPCFII 305
+W LK SD I + G L+ + W +V +I G+KS+GKV+Y P ++
Sbjct: 195 YWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVL 254
Query: 306 VGFFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASLASYMP 365
F+R + LEGA G+ + + + VW A Q+ + G G
Sbjct: 255 TILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGG--------- 305
Query: 366 QSNNCLSDAFLVSVINLLTLLVFTSFNFCVLGFWATVITHRCCERNAEILLKLINLGKLP 425
L+T+ + F H C R++ +++ + N
Sbjct: 306 ----------------LITMASYNKF-------------HNNCYRDS-VIISITNCA--- 332
Query: 426 PDAKPPVNLLYNPTSIYNAWLSGLPQHIKSMVLREVTECNIETQFLKASEGPKFAFLSFV 485
TS+Y ++ I S++ ++ + A GP AF+++
Sbjct: 333 -------------TSVYAGFV------IFSILGFMANHLGVDVSRV-ADHGPGLAFVAYP 372
Query: 486 EAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGIITPLQDTFS---FFRKHTKLLIVGV 542
EA++ LP S WS +FF ML+ +GL + +++ ++T + D +K T + + GV
Sbjct: 373 EALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTL-GV 431
Query: 543 FLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIVVVVFETMAVSWAYGARRFLADLTILL 602
+ F+ G+ T +G Y++ L+ +Y F ++V+ +A+ + YG R + D+ ++L
Sbjct: 432 AVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMML 491
Query: 603 GHPISPIFGWLWPHLCPVVLLIIFVTMMVHLCMKPITYMSWDSSTSKEVLRPYPPWALLL 662
G P F W + P ++ I V ++ +PITY + YP WA+ +
Sbjct: 492 GFPPPLFFQICWRFVSPAIIFFILVFTVIQ--YQPITYNHYQ----------YPGWAVAI 539
Query: 663 --MITLFAIVILPIPAYFVYCR 682
++ L +++ +P+ A F CR
Sbjct: 540 GFLMALSSVLCIPLYAMFRLCR 561
>gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo
sapiens]
Length = 706
Score = 223 bits (569), Expect = 4e-58
Identities = 159/622 (25%), Positives = 277/622 (44%), Gaps = 107/622 (17%)
Query: 92 TEKKESEVLLARPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFL 151
+E + + L R W ++ E++L VG+++ +WRF YL +GG +F Y ML
Sbjct: 89 SEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIF 148
Query: 152 VGVPLLFLEMAAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYM 211
G+PL F+E++ GQ QG +GVW+I +P GVGY +V +G+Y+NVV +Y
Sbjct: 149 CGIPLFFMELSFGQFASQGCLGVWRI-SPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYF 207
Query: 212 SQSFQFPVPWEKCPLTMNS-------------SGFDPEC-------------ERTTPSIY 245
S +PW C N+ +G P +RT+PS
Sbjct: 208 FSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEE 267
Query: 246 FWYQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLLPCFII 305
+W LK SD I + G L+ + W +V +I G+KS+GKV+Y P ++
Sbjct: 268 YWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVL 327
Query: 306 VGFFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASLASYMP 365
F+R + LEGA G+ + + + VW A Q+ + G G
Sbjct: 328 TILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGG--------- 378
Query: 366 QSNNCLSDAFLVSVINLLTLLVFTSFNFCVLGFWATVITHRCCERNAEILLKLINLGKLP 425
L+T+ + F H C R++ +++ + N
Sbjct: 379 ----------------LITMASYNKF-------------HNNCYRDS-VIISITNCA--- 405
Query: 426 PDAKPPVNLLYNPTSIYNAWLSGLPQHIKSMVLREVTECNIETQFLKASEGPKFAFLSFV 485
TS+Y ++ I S++ ++ + A GP AF+++
Sbjct: 406 -------------TSVYAGFV------IFSILGFMANHLGVDVSRV-ADHGPGLAFVAYP 445
Query: 486 EAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGIITPLQDTFS---FFRKHTKLLIVGV 542
EA++ LP S WS +FF ML+ +GL + +++ ++T + D +K T + + GV
Sbjct: 446 EALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTL-GV 504
Query: 543 FLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIVVVVFETMAVSWAYGARRFLADLTILL 602
+ F+ G+ T +G Y++ L+ +Y F ++V+ +A+ + YG R + D+ ++L
Sbjct: 505 AVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMML 564
Query: 603 GHPISPIFGWLWPHLCPVVLLIIFVTMMVHLCMKPITYMSWDSSTSKEVLRPYPPWALLL 662
G P F W + P ++ I V ++ +PITY + YP WA+ +
Sbjct: 565 GFPPPLFFQICWRFVSPAIIFFILVFTVIQ--YQPITYNHYQ----------YPGWAVAI 612
Query: 663 --MITLFAIVILPIPAYFVYCR 682
++ L +++ +P+ A F CR
Sbjct: 613 GFLMALSSVLCIPLYAMFRLCR 634
>gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo
sapiens]
Length = 652
Score = 223 bits (569), Expect = 4e-58
Identities = 159/622 (25%), Positives = 277/622 (44%), Gaps = 107/622 (17%)
Query: 92 TEKKESEVLLARPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFL 151
+E + + L R W ++ E++L VG+++ +WRF YL +GG +F Y ML
Sbjct: 35 SEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIF 94
Query: 152 VGVPLLFLEMAAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYM 211
G+PL F+E++ GQ QG +GVW+I +P GVGY +V +G+Y+NVV +Y
Sbjct: 95 CGIPLFFMELSFGQFASQGCLGVWRI-SPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYF 153
Query: 212 SQSFQFPVPWEKCPLTMNS-------------SGFDPEC-------------ERTTPSIY 245
S +PW C N+ +G P +RT+PS
Sbjct: 154 FSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEE 213
Query: 246 FWYQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLLPCFII 305
+W LK SD I + G L+ + W +V +I G+KS+GKV+Y P ++
Sbjct: 214 YWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVL 273
Query: 306 VGFFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASLASYMP 365
F+R + LEGA G+ + + + VW A Q+ + G G
Sbjct: 274 TILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGG--------- 324
Query: 366 QSNNCLSDAFLVSVINLLTLLVFTSFNFCVLGFWATVITHRCCERNAEILLKLINLGKLP 425
L+T+ + F H C R++ +++ + N
Sbjct: 325 ----------------LITMASYNKF-------------HNNCYRDS-VIISITNCA--- 351
Query: 426 PDAKPPVNLLYNPTSIYNAWLSGLPQHIKSMVLREVTECNIETQFLKASEGPKFAFLSFV 485
TS+Y ++ I S++ ++ + A GP AF+++
Sbjct: 352 -------------TSVYAGFV------IFSILGFMANHLGVDVSRV-ADHGPGLAFVAYP 391
Query: 486 EAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGIITPLQDTFS---FFRKHTKLLIVGV 542
EA++ LP S WS +FF ML+ +GL + +++ ++T + D +K T + + GV
Sbjct: 392 EALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTL-GV 450
Query: 543 FLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIVVVVFETMAVSWAYGARRFLADLTILL 602
+ F+ G+ T +G Y++ L+ +Y F ++V+ +A+ + YG R + D+ ++L
Sbjct: 451 AVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMML 510
Query: 603 GHPISPIFGWLWPHLCPVVLLIIFVTMMVHLCMKPITYMSWDSSTSKEVLRPYPPWALLL 662
G P F W + P ++ I V ++ +PITY + YP WA+ +
Sbjct: 511 GFPPPLFFQICWRFVSPAIIFFILVFTVIQ--YQPITYNHYQ----------YPGWAVAI 558
Query: 663 --MITLFAIVILPIPAYFVYCR 682
++ L +++ +P+ A F CR
Sbjct: 559 GFLMALSSVLCIPLYAMFRLCR 580
>gi|188528618 solute carrier family 6 (neurotransmitter transporter,
GABA), member 1 [Homo sapiens]
Length = 599
Score = 222 bits (566), Expect = 8e-58
Identities = 167/640 (26%), Positives = 278/640 (43%), Gaps = 100/640 (15%)
Query: 52 SAARVAEAQARTSQPKQISVLEALTASALNQKPTHEKVQMTEKKESEVLLARPFWSSKTE 111
+ ++VA+ Q T E A N KP V++ +K++ L R W + +
Sbjct: 4 NGSKVADGQIST---------EVSEAPVANDKPKTLVVKV--QKKAADLPDRDTWKGRFD 52
Query: 112 YILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPLLFLEMAAGQSMRQGG 171
++++ VG+++ +WRF YL +GG +F Y L GVPL LE + GQ GG
Sbjct: 53 FLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGG 112
Query: 172 MGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPWEKCPLTMNSS 231
+GVWK+ AP GVG ++ ++ F L +Y+ V+ SW I+Y+ SF +PW++C N+
Sbjct: 113 LGVWKL-APMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTD 171
Query: 232 ------GFDPECERTTPSIYFWYQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGAFMIN 285
T+ + FW + + +D ++ G + L + + W LV +
Sbjct: 172 RCFSNYSMVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWK 231
Query: 286 GLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSLAGGQ 345
G+ TGKV+Y P +++ F R + L GAK G+ + + + VW A Q
Sbjct: 232 GVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQ 291
Query: 346 VLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSVINLLTLLVFTSFNFCVLGFWATVITH 405
+ + G+GLGS+ +L SY NN D+ +V I N C F VI
Sbjct: 292 IFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCI-----------NSCTSMFAGFVIFS 340
Query: 406 RCCERNAEILLKLINLGKLPPDAKPPVNLLYNPTSIYNAWLSGLPQHIKSMVLREVTECN 465
+ G H+ + +V
Sbjct: 341 ----------------------------------------IVGFMAHVTKRSIADV---- 356
Query: 466 IETQFLKASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGIITPLQ 525
A+ GP AFL++ EA++ LP S W+ +FF MLL +G+ S ++G IT L
Sbjct: 357 -------AASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALV 409
Query: 526 DTF-SFFRKHTKLLIVGVFLLMFVCGLFFTRPSGSYFIRLLSDYWIV--FPIIVVVVFET 582
D + R +L I V ++ ++ GL G Y +L DY+ ++ +V FE
Sbjct: 410 DEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLF-DYYSASGMSLLFLVFFEC 468
Query: 583 MAVSWAYGARRFLADLTILLGHPISPIFGW--LWPHLCPVVLLIIFVTMMVHLCMKPITY 640
+++SW YG RF ++ ++G P W W P+++ +F+ V M P+T
Sbjct: 469 VSISWFYGVNRFYDNIQEMVGS--RPCIWWKLCWSFFTPIIVAGVFIFSAVQ--MTPLTM 524
Query: 641 MSWDSSTSKEVLRPYPPWALLLMITLFAIVILPIPAYFVY 680
++ +P W + + ++ IP Y Y
Sbjct: 525 GNY----------VFPKWGQGVGWLMALSSMVLIPGYMAY 554
>gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo
sapiens]
Length = 635
Score = 211 bits (537), Expect = 2e-54
Identities = 153/565 (27%), Positives = 253/565 (44%), Gaps = 96/565 (16%)
Query: 103 RPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPLLFLEMA 162
R W+ + ++I++ VGF++ +WRF YL +GG F Y+ + + G+P+ FLE++
Sbjct: 52 RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111
Query: 163 AGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPWE 222
GQ M+ G + VW I P G+GY+S ++ F Y+ +V +W +Y+ +SF +PW
Sbjct: 112 LGQFMKAGSINVWNI-CPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170
Query: 223 KCPLTMNSSGFDPEC-----------------------ERTTPSIYFWYQQALKASDRIE 259
C T N+ P+C +R +P I FW + L+ S +E
Sbjct: 171 TCGHTWNT----PDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLE 226
Query: 260 DGGSPVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAK 319
G+ + + L CW LV + G+KSTGK++Y P ++V +R +LL GA
Sbjct: 227 VPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGAL 286
Query: 320 FGLQQLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSV 379
G+ + S + + VW AG Q+ + IGLG+
Sbjct: 287 DGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGA----------------------- 323
Query: 380 INLLTLLVFTSFNFCVLGFWATVITHRCCERNAEILLKLINLGKLPPDAKPPVNLLYNPT 439
L L + FN C ++A I+L LIN G T
Sbjct: 324 --LTALGSYNRFN-------------NNCYKDA-IILALINSG----------------T 351
Query: 440 SIYNAWLSGLPQHIKSMVLREVTECNIETQFLKASEGPKFAFLSFVEAMSFLPPSVFWSF 499
S + ++ + S++ E + + A GP AF+++ A++ +P + W+
Sbjct: 352 SFFAGFV------VFSILGFMAAEQGVHISKV-AESGPGLAFIAYPRAVTLMPVAPLWAA 404
Query: 500 IFFLMLLAMGLSSAIGIMQGIITPLQDTFS---FFRKHTKLLIVGVFLLMFVCGLFFTRP 556
+FF MLL +GL S ++G IT L D +FR ++ + L FV L
Sbjct: 405 LFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTD 464
Query: 557 SGSYFIRLLSDYWIVFPIIVVVVF-ETMAVSWAYGARRFLADLTILLGHPISPIFGWLWP 615
G Y +L Y ++ F E + V+W YGA RF+ D+ ++G+ P W W
Sbjct: 465 GGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWS 524
Query: 616 HLCPVVLLIIFVTMMVHLCMKPITY 640
P+V + IF+ +V+ +P+ Y
Sbjct: 525 FFTPLVCMGIFIFNVVY--YEPLVY 547
>gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo
sapiens]
Length = 289
Score = 202 bits (514), Expect = 9e-52
Identities = 92/216 (42%), Positives = 142/216 (65%), Gaps = 2/216 (0%)
Query: 97 SEVLLARPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPL 156
SEV RP W+SK +YILAQVGFS+ +WRF YL +GG ++ Y+ +L ++G+PL
Sbjct: 55 SEVEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPL 114
Query: 157 LFLEMAAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQ 216
FLE++ GQ +R+G +GVW I+P +GG+G++S +VC+ + LY+NV+ W +FY SQSFQ
Sbjct: 115 FFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQ 174
Query: 217 FPVPWEKCPLTMNSSG--FDPECERTTPSIYFWYQQALKASDRIEDGGSPVYSLVLPFFL 274
P+PW++CPL N+S +PECE+++ + Y+WY++AL S I + G + + +
Sbjct: 175 QPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLA 234
Query: 275 CWCLVGAFMINGLKSTGKVIYVLVLLPCFIIVGFFI 310
W +V MI G++S+GKV + L I + FI
Sbjct: 235 AWVMVCLAMIKGIQSSGKVSMLEPFLILLITISGFI 270
>gi|7657587 solute carrier family 6 (neurotransmitter transporter,
GABA), member 11 [Homo sapiens]
Length = 632
Score = 199 bits (507), Expect = 6e-51
Identities = 147/599 (24%), Positives = 255/599 (42%), Gaps = 92/599 (15%)
Query: 95 KESEVLLARPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGV 154
K + + R W++K E++L+ G + +WRF YL +GG +F Y+ G+
Sbjct: 42 KRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGI 101
Query: 155 PLLFLEMAAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQS 214
P+ FLE A GQ +GG+ W+ + P G+GY++ ++ L +Y+ ++ +W IFY+S
Sbjct: 102 PVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNC 161
Query: 215 FQFPVPWEKC-------------PLTMNSSGFDPECERTTPSIYFWYQQALKASDRIEDG 261
F +PW C L +++ T+P + FW + L SD IE
Sbjct: 162 FTTELPWATCGHEWNTENCVEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHI 221
Query: 262 GSPVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAKFG 321
G+ + L L W + + G KSTGKV+YV P +++ IR + L GA G
Sbjct: 222 GNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEG 281
Query: 322 LQQLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSVIN 381
++ + +S + + VW AG Q+ + I LG + +L SY +NNC D ++ +N
Sbjct: 282 IKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLN 341
Query: 382 LLTLLVFTSFNFCVLGFWATVITHRCCERNAEILLKLINLGKLPPDAKPPVNLLYNPTSI 441
T V F VLGF
Sbjct: 342 SGTSFVAGFAIFSVLGFM------------------------------------------ 359
Query: 442 YNAWLSGLPQHIKSMVLREVTECNIETQFLKASEGPKFAFLSFVEAMSFLPPSVFWSFIF 501
A+ G+P + EV E F+ A+ V M P F+
Sbjct: 360 --AYEQGVP-------IAEVAESGPGLAFI--------AYPKAVTMMPLSPLWATLFFMM 402
Query: 502 FLMLLAMGLSSAIGIMQGIITPLQDTF-SFFRK--HTKLLIVGVFLLMFVCGLFFTRPSG 558
+ L GL S ++ ++T + D + FR+ +LLI+ + ++ + GL G
Sbjct: 403 LIFL---GLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGG 459
Query: 559 SYFIRLLSDYWIV-FPIIVVVVFETMAVSWAYGARRFLADLTILLGHPISPIFGWLWPHL 617
Y +L Y ++ V +FE + + W YG+ RF ++ ++G+ + W W +
Sbjct: 460 MYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIM 519
Query: 618 CPVVLLIIFVTMMVHLCMKPITYMSWDSSTSKEVLRPYPPWALLL--MITLFAIVILPI 674
P + IF+ ++ KP+ Y + + YP W + ++ L +++ +P+
Sbjct: 520 TPGICAGIFIFFLIK--YKPLKYNN---------IYTYPAWGYGIGWLMALSSMLCIPL 567
>gi|21361581 solute carrier family 6 (neurotransmitter transporter,
GABA), member 13 [Homo sapiens]
Length = 602
Score = 188 bits (478), Expect = 1e-47
Identities = 111/334 (33%), Positives = 168/334 (50%), Gaps = 14/334 (4%)
Query: 76 TASALNQKPTHEKVQMTEKKESEVLLARPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLN 135
T S KP + + EKKE + L R W++K E++L+ G + +WRF YL
Sbjct: 8 TTSNGETKPVYP---VMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYK 64
Query: 136 SGGCSFAAIYIFMLFLVGVPLLFLEMAAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFI 195
+GG +F Y+ LF G+P+ LE A GQ QGG+ W+ I P G+GY+S M+ +
Sbjct: 65 NGGGAFFIPYLVFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVIL 124
Query: 196 LGLYFNVVNSWIIFYMSQSFQFPVPWEKCPLTMN----------SSGFDPECER-TTPSI 244
L +Y+ +V +W +FY+ SF +PW C N + + E T+P I
Sbjct: 125 LNVYYIIVLAWALFYLFSSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENATSPVI 184
Query: 245 YFWYQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLLPCFI 304
FW ++ LK SD I+ G+ + L L L W + + G+KSTGKV+Y P +
Sbjct: 185 EFWERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLM 244
Query: 305 IVGFFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASLASYM 364
+V IR + L GA G+Q + ++ +++ VW AG Q+ + I LG + +L SY
Sbjct: 245 LVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYN 304
Query: 365 PQSNNCLSDAFLVSVINLLTLLVFTSFNFCVLGF 398
NNC D + +N T V F +LGF
Sbjct: 305 KYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGF 338
Score = 97.8 bits (242), Expect = 3e-20
Identities = 73/254 (28%), Positives = 122/254 (48%), Gaps = 35/254 (13%)
Query: 473 ASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGIITPLQDTFSF-F 531
A GP AF+++ A+ LP S W+ FF M++ +GL S ++ ++T L D + F
Sbjct: 351 AESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVF 410
Query: 532 RKHTK--LLIVGVFLLMFVCGLFFTRPSGSYFIRLLSDYWIV--FPIIVVVVFETMAVSW 587
RK + +LI+GV ++ F+ GL G Y +L DY+ ++ V +FE++ V+W
Sbjct: 411 RKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLF-DYYAASGMCLLFVAIFESLCVAW 469
Query: 588 AYGARRFLADLTILLGHPISPIFGWLWPHLCPVVLLIIFVTMMVHLCMKPITYMSWDSST 647
YGA+RF ++ ++G+ P+ + W L P V F+ ++ P+TY
Sbjct: 470 VYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIK--YTPLTY------- 520
Query: 648 SKEVLRPYPPWALLLMITLFAIVILPIPAYFVY-----------------CRIHRIPFR- 689
+K+ P+ AL ++ L ++V IPA+ +Y C +P R
Sbjct: 521 NKKYTYPWWGDALGWLLALSSMVC--IPAWSLYRLGTLKGPFRERIRQLMCPAEDLPQRN 578
Query: 690 PKSGDGPMTASTSL 703
P P T TSL
Sbjct: 579 PAGPSAPATPRTSL 592
>gi|197276623 solute carrier family 6 (neurotransmitter transporter,
taurine), member 6 isoform a [Homo sapiens]
Length = 620
Score = 171 bits (432), Expect = 3e-42
Identities = 102/316 (32%), Positives = 154/316 (48%), Gaps = 22/316 (6%)
Query: 103 RPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPLLFLEMA 162
R WSSK +++L+ G + +WRF YL +GG +F Y LF G+P+ FLE+
Sbjct: 41 REKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEII 100
Query: 163 AGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPWE 222
GQ +GG+ W+ I P G+GY+S ++ +L +Y+ V+ +W +Y+ QSFQ +PW
Sbjct: 101 IGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWA 160
Query: 223 KCPLTMNSSGFDPECER------------------TTPSIYFWYQQALKASDRIEDGGSP 264
C N S P C T+P I FW + L S I+ GS
Sbjct: 161 HC----NHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGIDHPGSL 216
Query: 265 VYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAKFGLQQ 324
+ L L L W + + G++STGKV+Y P +++ +R L L GA G++
Sbjct: 217 KWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKF 276
Query: 325 LVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSVINLLT 384
+ I+ + + VW AG Q+ + I LG++ SL SY N D L+ +N T
Sbjct: 277 YLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGT 336
Query: 385 LLVFTSFNFCVLGFWA 400
V F +LGF A
Sbjct: 337 SFVSGFAIFSILGFMA 352
>gi|54607094 solute carrier family 6 (neurotransmitter transporter,
taurine), member 6 isoform a [Homo sapiens]
Length = 620
Score = 171 bits (432), Expect = 3e-42
Identities = 102/316 (32%), Positives = 154/316 (48%), Gaps = 22/316 (6%)
Query: 103 RPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPLLFLEMA 162
R WSSK +++L+ G + +WRF YL +GG +F Y LF G+P+ FLE+
Sbjct: 41 REKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEII 100
Query: 163 AGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPWE 222
GQ +GG+ W+ I P G+GY+S ++ +L +Y+ V+ +W +Y+ QSFQ +PW
Sbjct: 101 IGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWA 160
Query: 223 KCPLTMNSSGFDPECER------------------TTPSIYFWYQQALKASDRIEDGGSP 264
C N S P C T+P I FW + L S I+ GS
Sbjct: 161 HC----NHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGIDHPGSL 216
Query: 265 VYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAKFGLQQ 324
+ L L L W + + G++STGKV+Y P +++ +R L L GA G++
Sbjct: 217 KWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKF 276
Query: 325 LVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSVINLLT 384
+ I+ + + VW AG Q+ + I LG++ SL SY N D L+ +N T
Sbjct: 277 YLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGT 336
Query: 385 LLVFTSFNFCVLGFWA 400
V F +LGF A
Sbjct: 337 SFVSGFAIFSILGFMA 352
>gi|171184408 solute carrier family 6 (neurotransmitter transporter,
betaine/GABA), member 12 [Homo sapiens]
Length = 614
Score = 166 bits (421), Expect = 5e-41
Identities = 98/324 (30%), Positives = 159/324 (49%), Gaps = 12/324 (3%)
Query: 87 EKVQMTEKKESEVLLARPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYI 146
E+ + ++++ + + R W++K E++L+ G + +WRF YL +GG +F Y
Sbjct: 20 EEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYF 79
Query: 147 FMLFLVGVPLLFLEMAAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSW 206
F+ G+P+ FLE+A GQ QG + W+ I P G+G +S ++ L +Y+ ++ +W
Sbjct: 80 IFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAW 139
Query: 207 IIFYMSQSFQFPVPW---------EKCPLTMNSSG---FDPECERTTPSIYFWYQQALKA 254
+FY+ SF +PW E C +N SG P T+P + FW ++ L
Sbjct: 140 ALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGI 199
Query: 255 SDRIEDGGSPVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLL 314
+ I D GS + L L L W + + G+KSTGKV+Y P ++V IR +
Sbjct: 200 TSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVT 259
Query: 315 LEGAKFGLQQLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASLASYMPQSNNCLSDA 374
L GA G+ + + + + VW AG Q+ + I G + +L SY NNC D
Sbjct: 260 LPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDC 319
Query: 375 FLVSVINLLTLLVFTSFNFCVLGF 398
+ +N T V F +LGF
Sbjct: 320 IALCFLNSATSFVAGFVVFSILGF 343
>gi|171184406 solute carrier family 6 (neurotransmitter transporter,
betaine/GABA), member 12 [Homo sapiens]
Length = 614
Score = 166 bits (421), Expect = 5e-41
Identities = 98/324 (30%), Positives = 159/324 (49%), Gaps = 12/324 (3%)
Query: 87 EKVQMTEKKESEVLLARPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYI 146
E+ + ++++ + + R W++K E++L+ G + +WRF YL +GG +F Y
Sbjct: 20 EEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYF 79
Query: 147 FMLFLVGVPLLFLEMAAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSW 206
F+ G+P+ FLE+A GQ QG + W+ I P G+G +S ++ L +Y+ ++ +W
Sbjct: 80 IFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAW 139
Query: 207 IIFYMSQSFQFPVPW---------EKCPLTMNSSG---FDPECERTTPSIYFWYQQALKA 254
+FY+ SF +PW E C +N SG P T+P + FW ++ L
Sbjct: 140 ALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGI 199
Query: 255 SDRIEDGGSPVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLL 314
+ I D GS + L L L W + + G+KSTGKV+Y P ++V IR +
Sbjct: 200 TSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVT 259
Query: 315 LEGAKFGLQQLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASLASYMPQSNNCLSDA 374
L GA G+ + + + + VW AG Q+ + I G + +L SY NNC D
Sbjct: 260 LPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDC 319
Query: 375 FLVSVINLLTLLVFTSFNFCVLGF 398
+ +N T V F +LGF
Sbjct: 320 IALCFLNSATSFVAGFVVFSILGF 343
>gi|171184404 solute carrier family 6 (neurotransmitter transporter,
betaine/GABA), member 12 [Homo sapiens]
Length = 614
Score = 166 bits (421), Expect = 5e-41
Identities = 98/324 (30%), Positives = 159/324 (49%), Gaps = 12/324 (3%)
Query: 87 EKVQMTEKKESEVLLARPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYI 146
E+ + ++++ + + R W++K E++L+ G + +WRF YL +GG +F Y
Sbjct: 20 EEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYF 79
Query: 147 FMLFLVGVPLLFLEMAAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSW 206
F+ G+P+ FLE+A GQ QG + W+ I P G+G +S ++ L +Y+ ++ +W
Sbjct: 80 IFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAW 139
Query: 207 IIFYMSQSFQFPVPW---------EKCPLTMNSSG---FDPECERTTPSIYFWYQQALKA 254
+FY+ SF +PW E C +N SG P T+P + FW ++ L
Sbjct: 140 ALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGI 199
Query: 255 SDRIEDGGSPVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLL 314
+ I D GS + L L L W + + G+KSTGKV+Y P ++V IR +
Sbjct: 200 TSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVT 259
Query: 315 LEGAKFGLQQLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASLASYMPQSNNCLSDA 374
L GA G+ + + + + VW AG Q+ + I G + +L SY NNC D
Sbjct: 260 LPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDC 319
Query: 375 FLVSVINLLTLLVFTSFNFCVLGF 398
+ +N T V F +LGF
Sbjct: 320 IALCFLNSATSFVAGFVVFSILGF 343
>gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo
sapiens]
Length = 625
Score = 164 bits (416), Expect = 2e-40
Identities = 93/309 (30%), Positives = 156/309 (50%), Gaps = 28/309 (9%)
Query: 103 RPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPLLFLEMA 162
R W+ + ++I++ VGF++ +WRF YL +GG F Y+ + + G+P+ FLE++
Sbjct: 52 RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111
Query: 163 AGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPWE 222
GQ M+ G + VW I P G+GY+S ++ F Y+ +V +W +Y+ +SF +PW
Sbjct: 112 LGQFMKAGSINVWNI-CPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170
Query: 223 KCPLTMNSSGFDPEC-----------------------ERTTPSIYFWYQQALKASDRIE 259
C T N+ P+C +R +P I FW + L+ S +E
Sbjct: 171 TCGHTWNT----PDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLE 226
Query: 260 DGGSPVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAK 319
G+ + + L CW LV + G+KSTGK++Y P ++V +R +LL GA
Sbjct: 227 VPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGAL 286
Query: 320 FGLQQLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSV 379
G+ + S + + VW AG Q+ + IGLG++ +L SY +NNC + +
Sbjct: 287 DGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYNGTSFFAG 346
Query: 380 INLLTLLVF 388
+ ++L F
Sbjct: 347 FVVFSILGF 355
Score = 89.0 bits (219), Expect = 1e-17
Identities = 52/172 (30%), Positives = 85/172 (49%), Gaps = 6/172 (3%)
Query: 473 ASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGIITPLQDTFS--- 529
A GP AF+++ A++ +P + W+ +FF MLL +GL S ++G IT L D
Sbjct: 368 AESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASY 427
Query: 530 FFRKHTKLLIVGVFLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIVVVVF-ETMAVSWA 588
+FR ++ + L FV L G Y +L Y ++ F E + V+W
Sbjct: 428 YFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWV 487
Query: 589 YGARRFLADLTILLGHPISPIFGWLWPHLCPVVLLIIFVTMMVHLCMKPITY 640
YGA RF+ D+ ++G+ P W W P+V + IF+ +V+ +P+ Y
Sbjct: 488 YGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVY--YEPLVY 537
>gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo
sapiens]
Length = 520
Score = 164 bits (415), Expect = 3e-40
Identities = 131/501 (26%), Positives = 214/501 (42%), Gaps = 96/501 (19%)
Query: 167 MRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPWEKCPL 226
M+ G + VW I P G+GY+S ++ F Y+ +V +W +Y+ +SF +PW C
Sbjct: 1 MKAGSINVWNI-CPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGH 59
Query: 227 TMNSSGFDPEC-----------------------ERTTPSIYFWYQQALKASDRIEDGGS 263
T N+ P+C +R +P I FW + L+ S +E G+
Sbjct: 60 TWNT----PDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGA 115
Query: 264 PVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAKFGLQ 323
+ + L CW LV + G+KSTGK++Y P ++V +R +LL GA G+
Sbjct: 116 LNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGII 175
Query: 324 QLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSVINLL 383
+ S + + VW AG Q+ + IGLG+ L
Sbjct: 176 YYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGA-------------------------LT 210
Query: 384 TLLVFTSFNFCVLGFWATVITHRCCERNAEILLKLINLGKLPPDAKPPVNLLYNPTSIYN 443
L + FN C ++A I+L LIN G TS +
Sbjct: 211 ALGSYNRFN-------------NNCYKDA-IILALINSG----------------TSFFA 240
Query: 444 AWLSGLPQHIKSMVLREVTECNIETQFLKASEGPKFAFLSFVEAMSFLPPSVFWSFIFFL 503
++ + S++ E + + A GP AF+++ A++ +P + W+ +FF
Sbjct: 241 GFV------VFSILGFMAAEQGVHISKV-AESGPGLAFIAYPRAVTLMPVAPLWAALFFF 293
Query: 504 MLLAMGLSSAIGIMQGIITPLQDTFS---FFRKHTKLLIVGVFLLMFVCGLFFTRPSGSY 560
MLL +GL S ++G IT L D +FR ++ + L FV L G Y
Sbjct: 294 MLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMY 353
Query: 561 FIRLLSDYWIVFPIIVVVVF-ETMAVSWAYGARRFLADLTILLGHPISPIFGWLWPHLCP 619
+L Y ++ F E + V+W YGA RF+ D+ ++G+ P W W P
Sbjct: 354 VFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTP 413
Query: 620 VVLLIIFVTMMVHLCMKPITY 640
+V + IF+ +V+ +P+ Y
Sbjct: 414 LVCMGIFIFNVVY--YEPLVY 432
>gi|4507041 solute carrier family 6 (neurotransmitter transporter,
dopamine), member 3 [Homo sapiens]
Length = 620
Score = 163 bits (413), Expect = 5e-40
Identities = 94/318 (29%), Positives = 159/318 (50%), Gaps = 25/318 (7%)
Query: 103 RPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPLLFLEMA 162
R W K +++L+ +GF++ + +WRF YL +GG +F Y+ + + G+PL ++E+A
Sbjct: 60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELA 119
Query: 163 AGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPWE 222
GQ R+G GVWK I P + GVG++ ++ +G ++NV+ +W + Y+ SF +PW
Sbjct: 120 LGQFNREGAAGVWK-ICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWI 178
Query: 223 KCPLTMNSSGFDPECE------------------RTTPSIYFWYQQA--LKASDRIEDGG 262
C N+S P C TTP+ ++ + L S I+D G
Sbjct: 179 HC----NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLG 234
Query: 263 SPVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAKFGL 322
P + L L L+ + G+K++GKV+++ +P ++ +R + L GA G+
Sbjct: 235 PPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGI 294
Query: 323 QQLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSVINL 382
+ + + SVW A QV + G+G G + + +SY +NNC DA + + IN
Sbjct: 295 RAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINS 354
Query: 383 LTLLVFTSFNFCVLGFWA 400
LT F LG+ A
Sbjct: 355 LTSFSSGFVVFSFLGYMA 372
Score = 102 bits (253), Expect = 2e-21
Identities = 63/213 (29%), Positives = 105/213 (49%), Gaps = 14/213 (6%)
Query: 473 ASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGIITPLQDTFSFFR 532
A +GP F+ + EA++ LP S W+ +FF+MLL +G+ SA+G M+ +IT L D F
Sbjct: 383 AKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLH 442
Query: 533 KHTKLLIVGVFLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIVVVVFETMAVSWAYGAR 592
+H +L + + L F+ LF G Y LL + I+ V+ E + V+W YG
Sbjct: 443 RHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVG 502
Query: 593 RFLADLTILLGHPISPIFGWLWPHLCPVVLLIIFVTMMVHLCMKPITYMSWDSSTSKEVL 652
+F D+ + G S + W + P LL + V +V +P Y ++
Sbjct: 503 QFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIV--TFRPPHYGAY--------- 551
Query: 653 RPYPPWALLL--MITLFAIVILPIPAYFVYCRI 683
+P WA L +I ++ ++PI A + +C +
Sbjct: 552 -IFPDWANALGWVIATSSMAMVPIYAAYKFCSL 583
>gi|134304856 solute carrier family 6, member 7 [Homo sapiens]
Length = 636
Score = 157 bits (398), Expect = 3e-38
Identities = 96/340 (28%), Positives = 169/340 (49%), Gaps = 25/340 (7%)
Query: 82 QKPTHEKVQMTEKKESEVLLARPF------WSSKTEYILAQVGFSMKPSCLWRFAYLWLN 135
+KP + MT + +V L F W+ K +++L+ +G+ + +WRF Y
Sbjct: 10 RKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYT 69
Query: 136 SGGCSFAAIYIFMLFLVGVPLLFLEMAAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFI 195
+GG +F Y ML + G+PL FLE++ GQ G + VWKI +P G G + ++ +
Sbjct: 70 NGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKI-SPLFKGAGAAMLLIVGL 128
Query: 196 LGLYFNVVNSWIIFYMSQSFQFPVPWEKCP------------LTMNSSGFDP---ECERT 240
+ +Y+N++ ++++FY+ S +PWE C ++ + +G P C
Sbjct: 129 VAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCT-V 187
Query: 241 TPSIYFW--YQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLV 298
+PS +W Y ++ S I G ++L L L W +V ++ G+KS+GKV+Y
Sbjct: 188 SPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTA 247
Query: 299 LLPCFIIVGFFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVA 358
P I++ +R + L GA G+Q + + + + VW A Q+ + G+G G +
Sbjct: 248 TFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLL 307
Query: 359 SLASYMPQSNNCLSDAFLVSVINLLTLLVFTSFNFCVLGF 398
+ ASY N D F+V++ N +T ++ F VLG+
Sbjct: 308 TFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGY 347
Score = 122 bits (305), Expect = 2e-27
Identities = 73/205 (35%), Positives = 109/205 (53%), Gaps = 13/205 (6%)
Query: 473 ASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGIITPLQDTFSFFR 532
A GP AF+ + +AM+ LP S FWSF+FF MLL +GL S ++ I+T + D F ++
Sbjct: 360 AKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYL 419
Query: 533 KHTKLLIVG-VFLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIVVVVFETMAVSWAYGA 591
+ K + G + + M++ GL T G Y++ LL DY F ++VVV+ +AV+ YG
Sbjct: 420 RPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGI 479
Query: 592 RRFLADLTILLGHPISPIFGWLWPHLCPVVLLIIFVTMMVHLCMKPITYMSWDSSTSKEV 651
+RF D+ ++LG F W L P LL + V +V +P Y S+
Sbjct: 480 QRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVK--YQPSEYGSY-------- 529
Query: 652 LRPYPPWALLLMITLFAIVILPIPA 676
+PPWA LL I + + L IPA
Sbjct: 530 --RFPPWAELLGILMGLLSCLMIPA 552
>gi|197276625 solute carrier family 6 (neurotransmitter transporter,
taurine), member 6 isoform b [Homo sapiens]
Length = 200
Score = 105 bits (261), Expect = 2e-22
Identities = 51/139 (36%), Positives = 77/139 (55%), Gaps = 4/139 (2%)
Query: 103 RPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPLLFLEMA 162
R WSSK +++L+ G + +WRF YL +GG +F Y LF G+P+ FLE+
Sbjct: 41 REKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEII 100
Query: 163 AGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPWE 222
GQ +GG+ W+ I P G+GY+S ++ +L +Y+ V+ +W +Y+ QSFQ +PW
Sbjct: 101 IGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWA 160
Query: 223 KCPLTMNSSGFDPECERTT 241
C N S P C T
Sbjct: 161 HC----NHSWNTPHCMEDT 175
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.326 0.138 0.441
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,468,692
Number of Sequences: 37866
Number of extensions: 1183830
Number of successful extensions: 4018
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 3874
Number of HSP's gapped (non-prelim): 61
length of query: 736
length of database: 18,247,518
effective HSP length: 110
effective length of query: 626
effective length of database: 14,082,258
effective search space: 8815493508
effective search space used: 8815493508
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.