Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 54607118
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|54607118 leucine-rich repeats and immunoglobulin-like
domains 1 [Homo sapiens]
(1093 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 2212 0.0
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 990 0.0
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 951 0.0
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 903 0.0
gi|109150416 peroxidasin [Homo sapiens] 226 1e-58
gi|126517478 peroxidasin homolog-like [Homo sapiens] 220 7e-57
gi|225579152 insulin-like growth factor binding protein, acid la... 185 2e-46
gi|4826772 insulin-like growth factor binding protein, acid labi... 183 9e-46
gi|188528675 slit homolog 1 [Homo sapiens] 172 2e-42
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 165 2e-40
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 162 2e-39
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 162 2e-39
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 160 6e-39
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 156 9e-38
gi|4759146 slit homolog 2 [Homo sapiens] 155 2e-37
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 148 2e-35
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 147 4e-35
gi|51317373 netrin-G1 ligand [Homo sapiens] 144 6e-34
gi|19743806 roundabout 1 isoform b [Homo sapiens] 142 2e-33
gi|4506569 roundabout 1 isoform a [Homo sapiens] 142 2e-33
gi|198041768 synleurin [Homo sapiens] 142 2e-33
gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 137 4e-32
gi|224994173 roundabout 1 isoform d [Homo sapiens] 137 7e-32
gi|224994171 roundabout 1 isoform c [Homo sapiens] 137 7e-32
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 137 7e-32
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 137 7e-32
gi|118572606 hemicentin 1 [Homo sapiens] 136 9e-32
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 136 9e-32
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 136 1e-31
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 134 5e-31
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 2212 bits (5731), Expect = 0.0
Identities = 1093/1093 (100%), Positives = 1093/1093 (100%)
Query: 1 MARPVRGGLGAPRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLA 60
MARPVRGGLGAPRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLA
Sbjct: 1 MARPVRGGLGAPRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLA 60
Query: 61 ALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSL 120
ALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSL
Sbjct: 61 ALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSL 120
Query: 121 FLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLEL 180
FLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLEL
Sbjct: 121 FLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLEL 180
Query: 181 GAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVL 240
GAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVL
Sbjct: 181 GAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVL 240
Query: 241 KLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHR 300
KLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHR
Sbjct: 241 KLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHR 300
Query: 301 KGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVL 360
KGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVL
Sbjct: 301 KGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVL 360
Query: 361 DLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRS 420
DLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRS
Sbjct: 361 DLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRS 420
Query: 421 VQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIF 480
VQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIF
Sbjct: 421 VQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIF 480
Query: 481 SVPPESFVCDDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNA 540
SVPPESFVCDDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNA
Sbjct: 481 SVPPESFVCDDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNA 540
Query: 541 DMENFVHVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPS 600
DMENFVHVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPS
Sbjct: 541 DMENFVHVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPS 600
Query: 601 FTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFIT 660
FTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFIT
Sbjct: 601 FTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFIT 660
Query: 661 DVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNP 720
DVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNP
Sbjct: 661 DVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNP 720
Query: 721 PPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
PPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV
Sbjct: 721 PPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
Query: 781 LPAAGCRKDGTTVGIFTIAVVSSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETVVPPDVP 840
LPAAGCRKDGTTVGIFTIAVVSSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETVVPPDVP
Sbjct: 781 LPAAGCRKDGTTVGIFTIAVVSSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETVVPPDVP 840
Query: 841 SYLSSQGTLSDRQETVVRTEGGPQANGHIESNGVCPRDASHFPEPDTHSVACRQPKLCAG 900
SYLSSQGTLSDRQETVVRTEGGPQANGHIESNGVCPRDASHFPEPDTHSVACRQPKLCAG
Sbjct: 841 SYLSSQGTLSDRQETVVRTEGGPQANGHIESNGVCPRDASHFPEPDTHSVACRQPKLCAG 900
Query: 901 SAYHKEPWKAMEKAEGTPGPHKMEHGGRVVCSDCNTEVDCYSRGQAFHPQPVSRDSAQPS 960
SAYHKEPWKAMEKAEGTPGPHKMEHGGRVVCSDCNTEVDCYSRGQAFHPQPVSRDSAQPS
Sbjct: 901 SAYHKEPWKAMEKAEGTPGPHKMEHGGRVVCSDCNTEVDCYSRGQAFHPQPVSRDSAQPS 960
Query: 961 APNGPEPGGSDQEHSPHHQCSRTAAGSCPECQGSLYPSNHDRMLTAVKKKPMASLDGKGD 1020
APNGPEPGGSDQEHSPHHQCSRTAAGSCPECQGSLYPSNHDRMLTAVKKKPMASLDGKGD
Sbjct: 961 APNGPEPGGSDQEHSPHHQCSRTAAGSCPECQGSLYPSNHDRMLTAVKKKPMASLDGKGD 1020
Query: 1021 SSWTLARLYHPDSTELQPASSLTSGSPERAEAQYLLVSNGHLPKACDASPESTPLTGQLP 1080
SSWTLARLYHPDSTELQPASSLTSGSPERAEAQYLLVSNGHLPKACDASPESTPLTGQLP
Sbjct: 1021 SSWTLARLYHPDSTELQPASSLTSGSPERAEAQYLLVSNGHLPKACDASPESTPLTGQLP 1080
Query: 1081 GKQRVPLLLAPKS 1093
GKQRVPLLLAPKS
Sbjct: 1081 GKQRVPLLLAPKS 1093
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 990 bits (2560), Expect = 0.0
Identities = 533/1018 (52%), Positives = 685/1018 (67%), Gaps = 38/1018 (3%)
Query: 40 PCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYL 99
PC C C GD LDC + LA LP LPSW L+LS+N+LS I + L +L+EV L
Sbjct: 46 PCPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKL 105
Query: 100 NNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCF 159
NNNEL +P+LG S+++ L L N+I + LK + SLE LDLS NNI+E++ T F
Sbjct: 106 NNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ-TAF 164
Query: 160 PHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLN 219
P +K L L NR+ ++E G FD L+ +LL L+L++NRI+ +P + FKLP+L L+LN
Sbjct: 165 P-ALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELN 223
Query: 220 RNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSL 279
RN+I+ ++GLTFQGL +L+ LK+QRN ++KL DGAFWGLS M +L L++N+L E+ G L
Sbjct: 224 RNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWL 283
Query: 280 YGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLS 339
YGL L +LHLS N+I RI W FCQKL EL L+FN+L+RLD+ S LS L+ L +
Sbjct: 284 YGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIG 343
Query: 340 HNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAK 399
+N +S+IA+ AF+GL SL+ LDL +NEIS TIED +GAFSGLD L +L L GN+I+S+ K
Sbjct: 344 NNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITK 403
Query: 400 RAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRM 459
+AF+GL+ LEHL+L NAI S+Q +AF +MK L++LH+++ S LCDCQLKWLP W+
Sbjct: 404 KAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENN 463
Query: 460 LQAFVTATCAHPESLKGQSIFSVPPESFVCDDFLKPQIITQPETTMAMVGKDIRFTCSAA 519
Q+FV A+CAHP+ LKG+SIF+V P+ FVCDDF KPQI QPET A+ G ++ F CSAA
Sbjct: 464 FQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAA 523
Query: 520 SSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVI 579
SSS SPMTFAWKKDNE+L +A+MEN+ H+ AQ GEVMEYTTIL LR+V F EG+YQCVI
Sbjct: 524 SSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVI 583
Query: 580 TNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDGGTD 639
+NHFGS+YS KA+LTVN+LPSFTKTP D+TIR MARLECAA GHP PQIAWQKDGGTD
Sbjct: 584 SNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTD 643
Query: 640 FPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLVVPL 699
FPAARERRMHVMP+DDVFFI DVKI+D GVYSCTAQNSAGSISANATLTVLETPS + PL
Sbjct: 644 FPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPL 703
Query: 700 EDRVVSVGETVALQCKATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAG 759
DR V+ GET LQC A G+PPP++ W K D PL +TERH NQLL++ + DAG
Sbjct: 704 LDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAG 763
Query: 760 RYTCEMSNTLGTERAHSQLSVLPAAGCRK----------DG-TTVGIFTIAVVSSIVLTS 808
+YTCEMSNTLGTER + +LSV+P C DG TVG+ IAVV +V TS
Sbjct: 764 KYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTS 823
Query: 809 LVWVCIIYQTRKKSEEYSVTNTDETVVPPDVPSYLSSQGTLSDRQETVVRTEGGPQANGH 868
LVWV IIY TR+++E+ S+TNTDET +P D+PSYLSSQGTL+DRQ+ V +E G +
Sbjct: 824 LVWVVIIYHTRRRNEDCSITNTDETNLPADIPSYLSSQGTLADRQDGYVSSESGSH-HQF 882
Query: 869 IESNGVCPRDASHFPEPDTHSVACRQPKLCAGSAYHKEPWKAMEKAEGTPGPHKMEHGGR 928
+ S+G H H + + A + P+ G+ GP ++ G
Sbjct: 883 VTSSGAGFFLPQHDSSGTCHIDNSSEADVEAATDLFLCPFL------GSTGPMYLK--GN 934
Query: 929 VVCSDCNTEVDCYSRGQAFHPQPVSRDSAQPSAPNGPEPGGSDQEHSPHHQCSRTAAGSC 988
V SD + Y G + P+ V D +PS E + CS + SC
Sbjct: 935 VYGSD---PFETYHTGCSPDPRTVLMDHYEPSYIKKKE----------CYPCSHPSEESC 981
Query: 989 PECQGSLYPSNHDRMLTAVKKKPMASLDGKGDSSWTLARLYHPDSTELQPASSLTSGS 1046
++ +H R L + +G G + L + S +PAS +S S
Sbjct: 982 ERSFSNISWPSHVRKLL---NTSYSHNEGPGMKNLCLNKSSLDFSANPEPASVASSNS 1036
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 951 bits (2459), Expect = 0.0
Identities = 515/984 (52%), Positives = 666/984 (67%), Gaps = 38/984 (3%)
Query: 74 NLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGS 133
+LS+N+LS I + L +L+EV LNNNEL +P+LG S+++ L L N+I +
Sbjct: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPE 79
Query: 134 QLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTL 193
LK + SLE LDLS NNI+E++ T FP +K L L NR+ ++E G FD L+ +LL L
Sbjct: 80 HLKEFQSLETLDLSSNNISELQ-TAFP-ALQLKYLYLNSNRVTSMEPGYFDNLANTLLVL 137
Query: 194 RLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDG 253
+L++NRI+ +P + FKLP+L L+LNRN+I+ ++GLTFQGL +L+ LK+QRN ++KL DG
Sbjct: 138 KLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDG 197
Query: 254 AFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELV 313
AFWGLS M +L L++N+L E+ G LYGL L +LHLS N+I RI W FCQKL EL
Sbjct: 198 AFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELD 257
Query: 314 LSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIED 373
L+FN+L+RLD+ S LS L+ L + +N +S+IA+ AF+GL SL+ LDL +NEIS TIED
Sbjct: 258 LTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIED 317
Query: 374 TSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLK 433
+GAFSGLD L +L L GN+I+S+ K+AF+GL+ LEHL+L NAI S+Q +AF +MK L+
Sbjct: 318 MNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQ 377
Query: 434 ELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCDDFL 493
+LH+++ S LCDCQLKWLP W+ Q+FV A+CAHP+ LKG+SIF+V P+ FVCDDF
Sbjct: 378 QLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFP 437
Query: 494 KPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDG 553
KPQI QPET A+ G ++ F CSAASSS SPMTFAWKKDNE+L +A+MEN+ H+ AQ G
Sbjct: 438 KPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGG 497
Query: 554 EVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTT 613
EVMEYTTIL LR+V F EG+YQCVI+NHFGS+YS KA+LTVN+LPSFTKTP D+TIR
Sbjct: 498 EVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAG 557
Query: 614 TMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCT 673
MARLECAA GHP PQIAWQKDGGTDFPAARERRMHVMP+DDVFFI DVKI+D GVYSCT
Sbjct: 558 AMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCT 617
Query: 674 AQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPL 733
AQNSAGSISANATLTVLETPS + PL DR V+ GET LQC A G+PPP++ W K D PL
Sbjct: 618 AQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPL 677
Query: 734 SLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVLPAAGCRK----- 788
+TERH NQLL++ + DAG+YTCEMSNTLGTER + +LSV+P C
Sbjct: 678 VVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTA 737
Query: 789 -----DG-TTVGIFTIAVVSSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETVVPPDVPSY 842
DG TVG+ IAVV +V TSLVWV IIY TR+++E+ S+TNTDET +P D+PSY
Sbjct: 738 PSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIPSY 797
Query: 843 LSSQGTLSDRQETVVRTEGGPQANGHIESNGVCPRDASHFPEPDTHSVACRQPKLCAGSA 902
LSSQGTL+DRQ+ V +E G + + S+G H H + + A +
Sbjct: 798 LSSQGTLADRQDGYVSSESGSH-HQFVTSSGAGFFLPQHDSSGTCHIDNSSEADVEAATD 856
Query: 903 YHKEPWKAMEKAEGTPGPHKMEHGGRVVCSDCNTEVDCYSRGQAFHPQPVSRDSAQPSAP 962
P+ G+ GP ++ G V SD + Y G + P+ V D +PS
Sbjct: 857 LFLCPFL------GSTGPMYLK--GNVYGSD---PFETYHTGCSPDPRTVLMDHYEPSYI 905
Query: 963 NGPEPGGSDQEHSPHHQCSRTAAGSCPECQGSLYPSNHDRMLTAVKKKPMASLDGKGDSS 1022
E + CS + SC ++ +H R L + +G G +
Sbjct: 906 KKKE----------CYPCSHPSEESCERSFSNISWPSHVRKLL---NTSYSHNEGPGMKN 952
Query: 1023 WTLARLYHPDSTELQPASSLTSGS 1046
L + S +PAS +S S
Sbjct: 953 LCLNKSSLDFSANPEPASVASSNS 976
Score = 132 bits (331), Expect = 2e-30
Identities = 156/649 (24%), Positives = 258/649 (39%), Gaps = 110/649 (16%)
Query: 213 LTQLDLNRNRIRLIEGLTFQGL-------------------------------------- 234
+++ DL+ NR+ I+ + L
Sbjct: 16 ISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVE 75
Query: 235 ---------NSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGL-TA 284
SLE L L NNIS+L AF L ++ L+L N + + G L
Sbjct: 76 ILPEHLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANT 133
Query: 285 LHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSIS 344
L L L+ N I+ I K + Q L L L+ N + +D + L +L L++ N ++
Sbjct: 134 LLVLKLNRNRISAIPPKMFKLPQ-LQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVT 192
Query: 345 HIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSG 404
+ +GAF GL ++ +L LDHN ++ E T G GL L +L L N I ++ A+
Sbjct: 193 KLMDGAFWGLSNMEILQLDHNNLT---EITKGWLYGLLMLQELHLSQNAINRISPDAWEF 249
Query: 405 LEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSD--SFLCDCQLKWLP---------- 452
+ L L+L N + + +F+ + L LHI ++ S++ DC + L
Sbjct: 250 CQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN 309
Query: 453 --PWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCDDFLKPQIITQPETTMAMVG- 509
W I M AF L+G I S+ ++F D L+ + M++ G
Sbjct: 310 EISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALE-HLDLSDNAIMSLQGN 368
Query: 510 -----KDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILHL 564
K ++ SS W + + + ++FV+ ++++ +I
Sbjct: 369 AFSQMKKLQQLHLNTSSLLCDCQLKWLP--QWVAENNFQSFVNASCAHPQLLKGRSIF-- 424
Query: 565 RQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTTMARLECAATG 624
V + F K ++TV + I+ + ++ + AA+
Sbjct: 425 ------------AVSPDGFVCDDFPKPQITV-------QPETQSAIKGSNLSFICSAASS 465
Query: 625 HPNPQ-IAWQKDGGTDFPAARERRMH-------VMPDDDVFFITDVKIDDAGVYSCTAQN 676
+P AW+KD A E H VM + + +V+ G Y C N
Sbjct: 466 SDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISN 525
Query: 677 SAG-SISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKG---DRP 732
G S S A LTV PS D + G L+C A G+P P+I W K D P
Sbjct: 526 HFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFP 585
Query: 733 LSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVL 781
+ R H+ P++ + + +V ED G Y+C N+ G+ A++ L+VL
Sbjct: 586 AARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVL 634
Score = 44.7 bits (104), Expect = 5e-04
Identities = 37/115 (32%), Positives = 62/115 (53%), Gaps = 6/115 (5%)
Query: 326 SLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLS 385
SL L +S LSHN +S I + L+SLR + L++NE+ TI + + +++
Sbjct: 9 SLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELE-TIPNLGPVSA---NIT 64
Query: 386 KLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSD 440
L+L GN+I + + LE L+L N I +Q AF ++ LK L+++S+
Sbjct: 65 LLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ-TAFPALQ-LKYLYLNSN 117
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 903 bits (2333), Expect = 0.0
Identities = 500/1003 (49%), Positives = 637/1003 (63%), Gaps = 79/1003 (7%)
Query: 41 CAAACTCAGDSLDCGGRGLAA-----LPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQ 95
C A C+C LDC R L A L G LP T L+ S+N+LS + + + LQ
Sbjct: 43 CPAPCSCRIPLLDCSRRKLPAPSWRALSGLLPPDTAILDFSHNRLSNWNIS--LESQTLQ 100
Query: 96 EVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVR 155
EV +N NELT +P G +S++ L L HN I + L+ Y +LE LDLS N I+E++
Sbjct: 101 EVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIK 160
Query: 156 NTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQ 215
+ FP +K LNL+ NRI TLE G FD LS SLL ++L++NR++ +P + FKLP L
Sbjct: 161 TSSFPR-MQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQF 219
Query: 216 LDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVN 275
L+L RNRI+++EGLTFQGL+SL LK+QRN ISKL DGAF+GL+ M L LE+N+L VN
Sbjct: 220 LELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVN 279
Query: 276 SGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSV 335
G LYGL L QL++S N+I RI W FCQ+L EL LS+N LTRLDE + LS L
Sbjct: 280 KGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLER 339
Query: 336 LRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIK 395
L L N ++HIA+G F+ L +L+ LDL +NEIS IED S AF+GL SL+KL L GN+IK
Sbjct: 340 LNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIK 399
Query: 396 SVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWL 455
S+ K+AF GLE LEHL+L NAI S+Q +AF +LKEL +++ S LCDC LKWL WL
Sbjct: 400 SITKKAFIGLESLEHLDLNNNAIMSIQENAF-SQTHLKELILNTSSLLCDCHLKWLLQWL 458
Query: 456 IGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCDDFLKPQIITQPETTMAMVGKDIRFT 515
+ Q V +CAHPE L GQSI +V + FVCDDFLKPQI T PET +A+ G ++ T
Sbjct: 459 VDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPETIIALRGMNVTLT 518
Query: 516 CSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILHLRQVTFGHEGRY 575
C+A SSS SPM+ W+KD+E+L + D ENFV Q GE +EYT+ILHL V F EG+Y
Sbjct: 519 CTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKY 578
Query: 576 QCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKD 635
QC++TNHFGS YS KA+LTVN +PSF KTP D+TIRT MARLECAA GHP PQI+WQKD
Sbjct: 579 QCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKD 638
Query: 636 GGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAGSISANATLTVLETPSL 695
GGTDFPAARERRMHVMP+DDVFFI +VKI+D G+YSC AQN+AG +SANA+LTVLETPS
Sbjct: 639 GGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAGGLSANASLTVLETPSF 698
Query: 696 VVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVA 755
+ PLED+ V+ GET LQC A G+P PR+ W K D PL +TERH NQLL++ +
Sbjct: 699 IRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGL 758
Query: 756 EDAGRYTCEMSNTLGTERAHSQLSVLPAAGC---------RKDG-TTVGIFTIAVVSSIV 805
EDAG+YTC MSNTLGTER H L+V+ + C DG TTVGI I VV +V
Sbjct: 759 EDAGKYTCIMSNTLGTERGHIYLNVISSPNCDSSQSSIGHEDDGWTTVGIVIIVVVCCVV 818
Query: 806 LTSLVWVCIIYQTRKKSEEYSVTNTDETVVPPDVPSYLSSQGTLSDRQETVVRTEGG--- 862
TSL+WV +IY R+K+E+YS+TNT+E +P D+PSYLSSQGTLS+ QE +E G
Sbjct: 819 GTSLIWVIVIYHMRRKNEDYSITNTEELNLPADIPSYLSSQGTLSEPQEGYSNSEAGSHQ 878
Query: 863 ---PQANGHIESNGVCPRDASHFPEPDTHSVACRQPKLCAGSAYHKEPWKAMEKAEGTPG 919
P ANG+I HK GT G
Sbjct: 879 QLMPPANGYI----------------------------------HK----------GTDG 894
Query: 920 PHKMEHGGRVVCSDCNTEVDCYSRGQAFHPQPVSRD----SAQPSAPNGPEPGGSDQEHS 975
G RV+CSDC + YSR + + P + S+ P + H
Sbjct: 895 ----GTGTRVICSDCYDNANIYSRTREYCPYTYIAEEDVLDQTLSSLMVQMPKETYLVHP 950
Query: 976 PHHQCSRTAAGSCPECQGSLYPSNHDRMLTAVKKKPMASLDGK 1018
P + + + S +P+NH+R+ + KK P + G+
Sbjct: 951 PQDTTALESLIPSANREPSAFPTNHERI--SEKKLPSTQMSGE 991
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 226 bits (575), Expect = 1e-58
Identities = 150/476 (31%), Positives = 235/476 (49%), Gaps = 26/476 (5%)
Query: 312 LVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTI 371
L L FN + + + L +L+ L L++N I I GAF+ L +L+ L L NEI
Sbjct: 67 LDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSID 126
Query: 372 EDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKN 431
AF GL SL +L L N+I+++ +F L LE L L N I + F +++
Sbjct: 127 RQ---AFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLES 183
Query: 432 LKELHISSDSFLCDCQLKWLPPWL--IGRMLQAFVTATCAHPESLKGQSIFSVPPESFVC 489
+K L + S++ CDC++ WL L A A C +P ++G+S+ ++ PE C
Sbjct: 184 MKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEELNC 243
Query: 490 DDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVH 549
+ +P+I ++P+ G + FTC A + P + +NE+ D +
Sbjct: 244 E---RPRITSEPQDADVTSGNTVYFTCRA-EGNPKPEIIWLRNNNELSMKTDSRLNL--- 296
Query: 550 AQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTV---NVLPSFTKTPH 606
DG +M T Q T +G YQC+ N G + + L P+F P
Sbjct: 297 LDDGTLMIQNT-----QET--DQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQ 349
Query: 607 DITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDD 666
+ + LEC+ATGHP P+I+W + T P + R+++ P ++ I +V D
Sbjct: 350 NTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPV--DPRVNITPSGGLY-IQNVVQGD 406
Query: 667 AGVYSCTAQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITW 726
+G Y+C+A N+ S+ A A + V P V +DRVV G+TV QC+A GNPPP I W
Sbjct: 407 SGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAW 466
Query: 727 FKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVLP 782
KG LS+ +R HL + L + V D G+Y C+ N +G+++ + L+V P
Sbjct: 467 TKGGSQLSV-DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQP 521
Score = 164 bits (414), Expect = 6e-40
Identities = 159/596 (26%), Positives = 251/596 (42%), Gaps = 53/596 (8%)
Query: 189 SLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNI 247
S+L LR NRI ++ AF+ L L L LN N+I+ I F+ L +L+ L L +N I
Sbjct: 65 SILDLRF--NRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEI 122
Query: 248 SKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQ 307
+ AF GL+ + L+L +N + ++ S L L +L L NN I + ++ +
Sbjct: 123 QSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLE 182
Query: 308 KLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEI 367
+ L L +N D E L L S N+ + + ++ V + E+
Sbjct: 183 SMKRLRLD-SNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEEL 241
Query: 368 SGTIEDTSGAFSGLDSLSKLTL-FGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAF 426
+ + D S T+ F + + K L L++ ++ ++ D
Sbjct: 242 NCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGT 301
Query: 427 VKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPES 486
+ ++N +E +D + C K + G + VT F P
Sbjct: 302 LMIQNTQE----TDQGIYQCMAKNVA----GEVKTQEVTLR-----------YFGSPA-- 340
Query: 487 FVCDDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFV 546
+P + QP+ T +VG+ + CSA + P +W + + T ++ V
Sbjct: 341 -------RPTFVIQPQNTEVLVGESVTLECSA--TGHPPPRISWTRGDR--TPLPVDPRV 389
Query: 547 HVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPH 606
++ G L+++ V G G Y C TN+ S ++ A + V LP FT TP
Sbjct: 390 NITPSGG--------LYIQNVVQGDSGEYACSATNNIDSVHA-TAFIIVQALPQFTVTPQ 440
Query: 607 DITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDD 666
D + +C A G+P P IAW K GG+ R H++ I+ V + D
Sbjct: 441 DRVVIEGQTVDFQCEAKGNPPPVIAWTK-GGSQLSVDRR---HLVLSSGTLRISGVALHD 496
Query: 667 AGVYSCTAQNSAGSISANATLTVLE--TPSLVVPLEDRVVSVGETVALQCKATGNPPPRI 724
G Y C A N GS A LTV TP D V VG V L C + G P P I
Sbjct: 497 QGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAI 556
Query: 725 TWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
TW K ++ + + H++P+ L + +V DAGRY C NT+G+ LSV
Sbjct: 557 TWNKDGVQVTESGKFHISPEG-FLTINDVGPADAGRYECVARNTIGSASVSMVLSV 611
Score = 88.2 bits (217), Expect = 4e-17
Identities = 65/186 (34%), Positives = 90/186 (48%), Gaps = 5/186 (2%)
Query: 17 CLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNLS 76
CLL L L A P A C + C C ++ C L A+P P T L+L
Sbjct: 12 CLLALVLFCAWGTLAVVAQKPGAGCPSRCLCFRTTVRCMHLLLEAVPAVAPQ-TSILDLR 70
Query: 77 YNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASS--HVVSLFLQHNKIRSVEGSQ 134
+N++ EI P F L NL + LNNN++ +PS GA ++ L+L N+I+S++
Sbjct: 71 FNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPS-GAFEDLENLKYLYLYKNEIQSIDRQA 129
Query: 135 LKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLR 194
K SLE L L N I + F H P ++ L L NRI L G F+ L S+ LR
Sbjct: 130 FKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHL-ESMKRLR 188
Query: 195 LSKNRI 200
L N +
Sbjct: 189 LDSNTL 194
Score = 73.6 bits (179), Expect = 1e-12
Identities = 49/157 (31%), Positives = 72/157 (45%), Gaps = 24/157 (15%)
Query: 211 PRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNS 270
P+ + LDL NRIR I+ F+ L +L L L N I ++ GAF L + L+L N
Sbjct: 62 PQTSILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNE 121
Query: 271 LVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAEL 330
+ ++ + GL +L QL+ L FN + LD +S L
Sbjct: 122 IQSIDRQAFKGLASLEQLY------------------------LHFNQIETLDPDSFQHL 157
Query: 331 SSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEI 367
L L L +N I+H+ G F L S++ L LD N +
Sbjct: 158 PKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTL 194
Score = 67.8 bits (164), Expect = 5e-11
Identities = 49/134 (36%), Positives = 73/134 (54%), Gaps = 2/134 (1%)
Query: 163 PPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRN 221
P L+L NRI ++ GAF L R+L TL L+ N+I ++P AF+ L L L L +N
Sbjct: 62 PQTSILDLRFNRIREIQPGAFRRL-RNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKN 120
Query: 222 RIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYG 281
I+ I+ F+GL SLE L L N I L +F L K+ L L N + + G+
Sbjct: 121 EIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNH 180
Query: 282 LTALHQLHLSNNSI 295
L ++ +L L +N++
Sbjct: 181 LESMKRLRLDSNTL 194
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 220 bits (560), Expect = 7e-57
Identities = 152/489 (31%), Positives = 229/489 (46%), Gaps = 40/489 (8%)
Query: 307 QKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNE 366
Q+ L L FN + + + +L +L+ L L++N I I+ AF+GL +L L L NE
Sbjct: 50 QQTTVLDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNE 109
Query: 367 ISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAF 426
I + T F GL SL L + N+++ + F L LE L L N + + +F
Sbjct: 110 IHALDKQT---FKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSF 166
Query: 427 VKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFV-------TATCAHPESLKGQSI 479
+ +LK L + S++ +CDC L WL G +LQ F ATC +P L G+++
Sbjct: 167 SNLDSLKRLRLDSNALVCDCDLMWL-----GELLQGFAQHGHTQAAATCEYPRRLHGRAV 221
Query: 480 FSVPPESFVCDDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTN 539
SV E F C P+I +P+ G + FTC A + + W +N L
Sbjct: 222 ASVTVEEFNCQS---PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEII--WIHNNHSL-- 274
Query: 540 ADMENFVHVHA-QDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVL 598
D+E+ ++ DG +M +R +G YQC+ N G + A L + L
Sbjct: 275 -DLEDDTRLNVFDDGTLM-------IRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSL 326
Query: 599 P---SFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDD 655
P SF P D + T LEC ATGHP+P I W +D G + +R HV
Sbjct: 327 PAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSR----HVATSSG 382
Query: 656 VFFITDVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCK 715
++ + ++ D G ++C A NS G++ A A + V P V +D+VV V C+
Sbjct: 383 LY-LQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCE 441
Query: 716 ATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAH 775
A GNPPP I W K L + E H + L + D G+Y C+ ++LG ++
Sbjct: 442 ADGNPPPVIVWTKTGGQLPV-EGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVS 500
Query: 776 SQLSVLPAA 784
QL+V P A
Sbjct: 501 VQLTVKPKA 509
Score = 106 bits (265), Expect = 1e-22
Identities = 82/294 (27%), Positives = 117/294 (39%), Gaps = 22/294 (7%)
Query: 494 KPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDG 553
KP + QP+ T ++G C A +T W +DN + +++ HV G
Sbjct: 329 KPSFVIQPQDTEVLIGTSTTLECMATGHPHPLIT--WTRDNGL----ELDGSRHVATSSG 382
Query: 554 EVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTT 613
L+L+ +T GR+ C N G T A + V P FT TP D +
Sbjct: 383 --------LYLQNITQRDHGRFTCHANNSHG-TVQAAANIIVQAPPQFTVTPKDQVVLEE 433
Query: 614 TMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCT 673
C A G+P P I W K GG P + H + I D G Y C
Sbjct: 434 HAVEWLCEADGNPPPVIVWTKTGG-QLPVEGQ---HTVLSSGTLRIDRAAQHDQGQYECQ 489
Query: 674 AQNSAGSISANATLTVLETPSLVVPL--EDRVVSVGETVALQCKATGNPPPRITWFKGDR 731
A +S G + LTV V +D V VG+ + + C A G P P ITW K
Sbjct: 490 AVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGV 549
Query: 732 PLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVLPAAG 785
++ + + H+ D L + + D GRY C N+ G + L+V G
Sbjct: 550 QITESGKFHV-DDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAIQG 602
Score = 71.2 bits (173), Expect = 5e-12
Identities = 47/151 (31%), Positives = 76/151 (50%), Gaps = 6/151 (3%)
Query: 193 LRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTD 252
+ L + I Q+P + T LDL NRIR I G F+ L +L L L N+I K++
Sbjct: 38 MHLMLDHIPQVPQQT------TVLDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISR 91
Query: 253 GAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHEL 312
AF GL + L+L N + ++ + GL +L L++ N + + + + +L L
Sbjct: 92 NAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERL 151
Query: 313 VLSFNNLTRLDEESLAELSSLSVLRLSHNSI 343
L N L+++ S + L SL LRL N++
Sbjct: 152 FLHNNKLSKIPAGSFSNLDSLKRLRLDSNAL 182
Score = 69.7 bits (169), Expect = 1e-11
Identities = 46/165 (27%), Positives = 81/165 (49%), Gaps = 3/165 (1%)
Query: 37 PRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQE 96
P PC + C C ++ C L +P +P T L+L +N++ EI + F+ L NL
Sbjct: 20 PGLPCPSRCLCFKSTVRCMHLMLDHIP-QVPQQTTVLDLRFNRIREIPGSAFKKLKNLNT 78
Query: 97 VYLNNNELTAVP-SLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVR 155
+ LNNN + + + +++ L+L N+I +++ K +SLE L + N + ++
Sbjct: 79 LLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQ 138
Query: 156 NTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRI 200
F ++ L L N++ + G+F L SL LRL N +
Sbjct: 139 PETFGDLLRLERLFLHNNKLSKIPAGSFSNLD-SLKRLRLDSNAL 182
Score = 65.9 bits (159), Expect = 2e-10
Identities = 48/131 (36%), Positives = 68/131 (51%), Gaps = 2/131 (1%)
Query: 143 VLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQ 202
VLDL N I E+ + F + L L N I + AF+GL +LL L L KN I
Sbjct: 54 VLDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLE-NLLYLYLYKNEIHA 112
Query: 203 LPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKM 261
L + FK L L L ++ N++ +++ TF L LE L L N +SK+ G+F L +
Sbjct: 113 LDKQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSL 172
Query: 262 HVLHLEYNSLV 272
L L+ N+LV
Sbjct: 173 KRLRLDSNALV 183
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 185 bits (469), Expect = 2e-46
Identities = 144/452 (31%), Positives = 213/452 (47%), Gaps = 21/452 (4%)
Query: 2 ARPVRGGLGAPRRSPCLLLLWLLL-----LRLEPVTAAAGPRAPCAAACTCAGD------ 50
A P GGL LLL W+ L +P T C AAC C+ D
Sbjct: 39 ASPPAGGLALA----LLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADEL 94
Query: 51 SLDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAV-PS 109
S+ C R L LP +P T++L L N LS + PA F++L +L + L +L ++ P
Sbjct: 95 SVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQ 154
Query: 110 LGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELN 169
++ L L+ N++RS+ +L L LS N ++ + + F + +LN
Sbjct: 155 ALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLN 214
Query: 170 LAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEG 228
L N + L AF GL SL L L+ NR+ L F L L +LDL+RN +R I+
Sbjct: 215 LGWNSLAVLPDAAFRGLG-SLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKA 273
Query: 229 LTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQL 288
F L L+ L L RN I+ + GAF GL + L L +N + + + GL L L
Sbjct: 274 NVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVL 333
Query: 289 HLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAE 348
LS+N+IA + + + L EL L N + +L E S L L VL L HN + +
Sbjct: 334 RLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKA 393
Query: 349 GAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGL 408
GAF GL ++ V++L N + E F GL L L L G+ + + F+GL GL
Sbjct: 394 GAFLGLTNVAVMNLSGNCLRNLPEQ---VFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGL 450
Query: 409 EHLNLGGNAIRSVQFDAFVKMKNLKELHISSD 440
L L N + ++ + + L EL ++S+
Sbjct: 451 RRLFLKDNGLVGIEEQSLWGLAELLELDLTSN 482
Score = 154 bits (390), Expect = 3e-37
Identities = 127/424 (29%), Positives = 198/424 (46%), Gaps = 16/424 (3%)
Query: 73 LNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAV-PSLGAASSHVVSLFLQHNKIRSVE 131
LNL +N L+ + A F L +L+E+ L N L + P+L + + + L L N +R+++
Sbjct: 213 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 272
Query: 132 GSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLL 191
+ L+ L L N I V F ++ L+L+ NR+ L F GL L
Sbjct: 273 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLL-GLR 331
Query: 192 TLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKL 250
LRLS N I L R FK L L +L L NRIR + +F+GL LEVL L N + ++
Sbjct: 332 VLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEV 391
Query: 251 TDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLH 310
GAF GL+ + V++L N L + GL LH LHL + + RI ++ L
Sbjct: 392 KAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLR 451
Query: 311 ELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGT 370
L L N L ++E+SL L+ L L L+ N ++H+ F+GL L L L N ++
Sbjct: 452 RLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLA-- 509
Query: 371 IEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMK 430
E + A L L + N+++++ + L L +L+L N++R+ +
Sbjct: 510 -ELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFT----PQPP 564
Query: 431 NLKELHISSDSFLCDCQLKWL------PPWLIGRMLQAFVTATCAHPESLKGQSIFSVPP 484
L+ L + + + C C LK L P + R +QA P + +I P
Sbjct: 565 GLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASP 624
Query: 485 ESFV 488
V
Sbjct: 625 PEVV 628
Score = 61.2 bits (147), Expect = 5e-09
Identities = 48/154 (31%), Positives = 72/154 (46%), Gaps = 3/154 (1%)
Query: 288 LHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIA 347
L L N+++ + + L L L L L+ ++L L +L L L N + +A
Sbjct: 117 LWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLA 176
Query: 348 EGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEG 407
G F +L L L +N +S +ED G F GL SL L L N + + AF GL
Sbjct: 177 LGTFAHTPALASLGLSNNRLS-RLED--GLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGS 233
Query: 408 LEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDS 441
L L L GN + +Q F + L+EL +S ++
Sbjct: 234 LRELVLAGNRLAYLQPALFSGLAELRELDLSRNA 267
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 183 bits (464), Expect = 9e-46
Identities = 139/436 (31%), Positives = 208/436 (47%), Gaps = 17/436 (3%)
Query: 18 LLLLWLLL-----LRLEPVTAAAGPRAPCAAACTCAGD------SLDCGGRGLAALPGDL 66
LLL W+ L +P T C AAC C+ D S+ C R L LP +
Sbjct: 13 LLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGV 72
Query: 67 PSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAV-PSLGAASSHVVSLFLQHN 125
P T++L L N LS + PA F++L +L + L +L ++ P ++ L L+ N
Sbjct: 73 PGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERN 132
Query: 126 KIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDG 185
++RS+ +L L LS N ++ + + F + +LNL N + L AF G
Sbjct: 133 QLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRG 192
Query: 186 LSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQR 244
L SL L L+ NR+ L F L L +LDL+RN +R I+ F L L+ L L R
Sbjct: 193 LG-SLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDR 251
Query: 245 NNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWS 304
N I+ + GAF GL + L L +N + + + GL L L LS+N+IA + + +
Sbjct: 252 NLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFK 311
Query: 305 FCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDH 364
L EL L N + +L E S L L VL L HN + + GAF GL ++ V++L
Sbjct: 312 DLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSG 371
Query: 365 NEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFD 424
N + E F GL L L L G+ + + F+GL GL L L N + ++
Sbjct: 372 NCLRNLPEQ---VFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQ 428
Query: 425 AFVKMKNLKELHISSD 440
+ + L EL ++S+
Sbjct: 429 SLWGLAELLELDLTSN 444
Score = 154 bits (390), Expect = 3e-37
Identities = 127/424 (29%), Positives = 198/424 (46%), Gaps = 16/424 (3%)
Query: 73 LNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAV-PSLGAASSHVVSLFLQHNKIRSVE 131
LNL +N L+ + A F L +L+E+ L N L + P+L + + + L L N +R+++
Sbjct: 175 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 234
Query: 132 GSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLL 191
+ L+ L L N I V F ++ L+L+ NR+ L F GL L
Sbjct: 235 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLL-GLR 293
Query: 192 TLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKL 250
LRLS N I L R FK L L +L L NRIR + +F+GL LEVL L N + ++
Sbjct: 294 VLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEV 353
Query: 251 TDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLH 310
GAF GL+ + V++L N L + GL LH LHL + + RI ++ L
Sbjct: 354 KAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLR 413
Query: 311 ELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGT 370
L L N L ++E+SL L+ L L L+ N ++H+ F+GL L L L N ++
Sbjct: 414 RLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLA-- 471
Query: 371 IEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMK 430
E + A L L + N+++++ + L L +L+L N++R+ +
Sbjct: 472 -ELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFT----PQPP 526
Query: 431 NLKELHISSDSFLCDCQLKWL------PPWLIGRMLQAFVTATCAHPESLKGQSIFSVPP 484
L+ L + + + C C LK L P + R +QA P + +I P
Sbjct: 527 GLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASP 586
Query: 485 ESFV 488
V
Sbjct: 587 PEVV 590
Score = 61.2 bits (147), Expect = 5e-09
Identities = 48/154 (31%), Positives = 72/154 (46%), Gaps = 3/154 (1%)
Query: 288 LHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIA 347
L L N+++ + + L L L L L+ ++L L +L L L N + +A
Sbjct: 79 LWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLA 138
Query: 348 EGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEG 407
G F +L L L +N +S +ED G F GL SL L L N + + AF GL
Sbjct: 139 LGTFAHTPALASLGLSNNRLS-RLED--GLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGS 195
Query: 408 LEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDS 441
L L L GN + +Q F + L+EL +S ++
Sbjct: 196 LRELVLAGNRLAYLQPALFSGLAELRELDLSRNA 229
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 172 bits (436), Expect = 2e-42
Identities = 149/502 (29%), Positives = 225/502 (44%), Gaps = 35/502 (6%)
Query: 4 PVRGGLGAPRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALP 63
P G P R LLLW RL + C A CTC G ++DC G GL A+P
Sbjct: 5 PGWGSSAGPVRPELWLLLWAAAWRLGA--------SACPALCTCTGTTVDCHGTGLQAIP 56
Query: 64 GDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAAS--SHVVSLF 121
++P T L L+ N ++ I F L L+ + L N++ AV GA + L
Sbjct: 57 KNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAV-ERGAFDDMKELERLR 115
Query: 122 LQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELG 181
L N++ + + +L LDLS N I + F +K L L N+I +E G
Sbjct: 116 LNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEG 175
Query: 182 AFDGLSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVL 240
AF L R L L L+ N IT +PV +F +P+L L+ N + L + L
Sbjct: 176 AFRAL-RGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAW-----LSQW 229
Query: 241 KLQRNNISKLTD----GAFWGLSKMHVLHLEYNSLVEVNSGSLYGLT----ALHQLHLSN 292
QR I T + GL+ V E++ + +G + T + + +
Sbjct: 230 LRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCS 289
Query: 293 NSIARIHRKGW-----SFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIA 347
N I KG + + + E+ L N + + + + L + LS+N I+ IA
Sbjct: 290 NGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIA 349
Query: 348 EGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEG 407
AF+GLRSL L L N+I+ + G F GL +L L L NKI + AF L+
Sbjct: 350 PDAFQGLRSLNSLVLYGNKIT---DLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQN 406
Query: 408 LEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTAT 467
L L+L N I+S+ F ++ ++ LH++ + F+CDC LKWL +L ++ A
Sbjct: 407 LSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIET-SGAR 465
Query: 468 CAHPESLKGQSIFSVPPESFVC 489
CA P L + I + + F C
Sbjct: 466 CASPRRLANKRIGQIKSKKFRC 487
Score = 127 bits (319), Expect = 6e-29
Identities = 138/497 (27%), Positives = 205/497 (41%), Gaps = 92/497 (18%)
Query: 67 PSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNK 126
P+ R LN++ + SE +G E VP+ +S ++ N
Sbjct: 245 PASLRGLNVAEVQKSEFSCSG-------------QGEAGRVPTCTLSSGSCPAMCTCSNG 291
Query: 127 IRSVEGSQLKAYLS-----LEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELG 181
I G L A + + + L LN I + F ++ ++L+ N+I +
Sbjct: 292 IVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPD 351
Query: 182 AFDGLSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVL 240
AF GL RSL +L L N+IT LP F L L L LN N+I I FQ L +L +L
Sbjct: 352 AFQGL-RSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLL 410
Query: 241 KLQRNNISKLTDGAFWGLSKMHVLHLEYNSLV------------EVNSGSLYGLTALHQL 288
L N I L G F L + LHL N + N G
Sbjct: 411 SLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETSGARCASPR 470
Query: 289 HLSNNSIARIHRKGWSFCQKLHELV-----LSFNNLTRLD---------EESLAELSSLS 334
L+N I +I K + K + N+ D E ++ E SSL
Sbjct: 471 RLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLK 530
Query: 335 V-------------LRLSHNSISHI-AEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSG 380
+ LRL++N IS + A G FK L L+ ++L +N++S IED GAF G
Sbjct: 531 LTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVS-EIED--GAFEG 587
Query: 381 LDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKN--------- 431
S+S+L L N+++S+ F GL+GL L L N I + D+F ++N
Sbjct: 588 AASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDN 647
Query: 432 ---------------LKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTAT--CAHPESL 474
L L++ ++ F C+CQL WL WL R + VT C +P+ L
Sbjct: 648 QITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKI---VTGNPRCQNPDFL 704
Query: 475 KGQSIFSVPPESFVCDD 491
+ + V F C++
Sbjct: 705 RQIPLQDVAFPDFRCEE 721
Score = 107 bits (268), Expect = 5e-23
Identities = 91/354 (25%), Positives = 165/354 (46%), Gaps = 35/354 (9%)
Query: 165 IKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRI 223
+K++NL+ N++ +E GAF+G + S+ L L+ N++ + F+ L L L L NRI
Sbjct: 567 LKKINLSNNKVSEIEDGAFEGAA-SVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRI 625
Query: 224 RLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSL-VEVNSGSLYGL 282
I +F GL ++ +L L N I+ ++ GAF L + L+L N L G
Sbjct: 626 SCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGW 685
Query: 283 TALHQLHLSN------NSIARIHRKGWSF----CQKLHEL------------VLSFNNLT 320
++ N + + +I + +F C++ E + +
Sbjct: 686 LRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTVV 745
Query: 321 RLDEESLAEL-----SSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTS 375
R + L L +++ L L N + + G + L+++DL +N+IS ++
Sbjct: 746 RCSNKHLRALPKGIPKNVTELYLDGNQFT-LVPGQLSTFKYLQLVDLSNNKISSL---SN 801
Query: 376 GAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKEL 435
+F+ + L+ L L N ++ + AF GL L L+L GN I ++Q F + +L L
Sbjct: 802 SSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHL 861
Query: 436 HISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFVC 489
I ++ CDC L+WL W+ + + A CA P+ ++G+ + + P + F C
Sbjct: 862 AIGANPLYCDCHLRWLSSWVKTGYKEPGI-ARCAGPQDMEGKLLLTTPAKKFEC 914
Score = 55.8 bits (133), Expect = 2e-07
Identities = 44/162 (27%), Positives = 66/162 (40%), Gaps = 25/162 (15%)
Query: 37 PRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQE 96
PR C C C + C + L ALP +P N+ E
Sbjct: 730 PRPQCPQECACLDTVVRCSNKHLRALPKGIPK------------------------NVTE 765
Query: 97 VYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRN 156
+YL+ N+ T VP + ++ + L +NKI S+ S L L LS N + +
Sbjct: 766 LYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPP 825
Query: 157 TCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKN 198
F ++ L+L GN I TL+ G F ++ SL L + N
Sbjct: 826 LAFQGLRSLRLLSLHGNDISTLQEGIFADVT-SLSHLAIGAN 866
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 165 bits (417), Expect = 2e-40
Identities = 156/520 (30%), Positives = 217/520 (41%), Gaps = 84/520 (16%)
Query: 16 PCLLLLWLLLLRLEPVTAAAGPR-----APCAAACTCAGD----SLDCGGRGLAALPGDL 66
P L LWL A P+ C A C C D S DC GL+A+PGDL
Sbjct: 5 PGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDL 64
Query: 67 PSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNK 126
T L+LS N L+E+ P F L L+E+ L+ N L+ +P
Sbjct: 65 DPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIP------------------ 106
Query: 127 IRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGL 186
G SL++L L N + + P ++ L L N I + +F+GL
Sbjct: 107 -----GQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGL 161
Query: 187 SRSLLTLRLSKNRITQLPVRAF-KLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRN 245
S SL L L N +T++PVRA LP L + L NRI I FQ L SL VL L N
Sbjct: 162 S-SLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNN 220
Query: 246 NISKLTDGAFWGLSKMHVLHLEYNSLVE-----------------------VNSGSLYGL 282
I L +F GL + L L YN L E + + G
Sbjct: 221 RIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGN 280
Query: 283 TALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDE-ESLAELSSLSVLRLSHN 341
L +H +N I + R + + KLH LS N + E L +SL +L L+
Sbjct: 281 PLLQTIHFYDNPIQFVGRSAFQYLPKLH--TLSLNGAMDIQEFPDLKGTTSLEILTLTRA 338
Query: 342 SISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRA 401
I + G + L LRVL+L HN+I + + L ++ L N+I +
Sbjct: 339 GIRLLPSGMCQQLPRLRVLELSHNQI-----EELPSLHRCQKLEEIGLQHNRIWEIGADT 393
Query: 402 FSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQ 461
FS L L+ L+L NAIRS+ +AF + +L +L L D QL LP +G ++
Sbjct: 394 FSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLD------LTDNQLTTLPLAGLGGLMH 447
Query: 462 AFVTATCAHPESLKGQSIFSVPPESFVCDDFLKPQIITQP 501
LKG S ++F D F K +I+ P
Sbjct: 448 L----------KLKGNLALS---QAFSKDSFPKLRILEVP 474
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 162 bits (409), Expect = 2e-39
Identities = 142/493 (28%), Positives = 220/493 (44%), Gaps = 60/493 (12%)
Query: 41 CAAACTCAGDS-LDCGGRGLAALPGDLPSWTR-------------------------SLN 74
C + CTC+ S ++C G + A+P LP W +L
Sbjct: 31 CPSECTCSRASQVECTGARIVAVPTPLP-WNAMSLQILNTHITELNESPFLNISALIALR 89
Query: 75 LSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQ 134
+ N+LS I P F +L +L+ + L NN+L +P + LF
Sbjct: 90 IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLP---------IGLF------------- 127
Query: 135 LKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLR 194
+ SLE L LS N + +++ F +KEL L GN + + GAFD L L L
Sbjct: 128 -QGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLV-GLTKLN 185
Query: 195 LSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDG 253
L KN +T + R F+ L L L L NR+ I TF GL +L+ L LQ+N I L+ G
Sbjct: 186 LGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPG 245
Query: 254 AFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELV 313
F + L+L N + ++ L L++L L NS+ + + L EL
Sbjct: 246 LFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELW 305
Query: 314 LSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIED 373
L N+++ L + + L L VL LS N IS I+ GAF GL LR L L N ++D
Sbjct: 306 LYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTN----ALQD 361
Query: 374 TSG-AFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNL 432
G F L +L ++L N+++ + F+ + GL + L N + ++ F + L
Sbjct: 362 LDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKL 421
Query: 433 KELHISSDSFLCDCQLKWLPPWLIGRM--LQAFVTATCAHPESLKGQSIFSVPPESFVCD 490
EL + + + CD + L WL+ L C P +++GQS+ + V
Sbjct: 422 CELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPS 481
Query: 491 DFLKPQIITQPET 503
+ P++ + PET
Sbjct: 482 VHV-PEVPSYPET 493
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 162 bits (409), Expect = 2e-39
Identities = 142/493 (28%), Positives = 220/493 (44%), Gaps = 60/493 (12%)
Query: 41 CAAACTCAGDS-LDCGGRGLAALPGDLPSWTR-------------------------SLN 74
C + CTC+ S ++C G + A+P LP W +L
Sbjct: 25 CPSECTCSRASQVECTGARIVAVPTPLP-WNAMSLQILNTHITELNESPFLNISALIALR 83
Query: 75 LSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQ 134
+ N+LS I P F +L +L+ + L NN+L +P + LF
Sbjct: 84 IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLP---------IGLF------------- 121
Query: 135 LKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLR 194
+ SLE L LS N + +++ F +KEL L GN + + GAFD L L L
Sbjct: 122 -QGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLV-GLTKLN 179
Query: 195 LSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDG 253
L KN +T + R F+ L L L L NR+ I TF GL +L+ L LQ+N I L+ G
Sbjct: 180 LGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPG 239
Query: 254 AFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELV 313
F + L+L N + ++ L L++L L NS+ + + L EL
Sbjct: 240 LFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELW 299
Query: 314 LSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIED 373
L N+++ L + + L L VL LS N IS I+ GAF GL LR L L N ++D
Sbjct: 300 LYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTN----ALQD 355
Query: 374 TSG-AFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNL 432
G F L +L ++L N+++ + F+ + GL + L N + ++ F + L
Sbjct: 356 LDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKL 415
Query: 433 KELHISSDSFLCDCQLKWLPPWLIGRM--LQAFVTATCAHPESLKGQSIFSVPPESFVCD 490
EL + + + CD + L WL+ L C P +++GQS+ + V
Sbjct: 416 CELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPS 475
Query: 491 DFLKPQIITQPET 503
+ P++ + PET
Sbjct: 476 VHV-PEVPSYPET 487
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 160 bits (405), Expect = 6e-39
Identities = 137/447 (30%), Positives = 212/447 (47%), Gaps = 59/447 (13%)
Query: 20 LLWLLLLRLEPVTAAAGPRAP-CAAACTCAGD-SLDCGGRGLAALPGDLPSWTRSLNLSY 77
LL L L L +G P CAA C+C GD +DC G+GL A+P L ++T++L++S
Sbjct: 7 LLCFLALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISM 66
Query: 78 NKLSEIDPAGFEDLPNLQEVYLNNNELTAV-PSLGAASSHVVSLFLQHNKIRSVEGSQLK 136
N ++++ F++ P L+E+ L N+L+ + P + + L LQ+N++++V ++
Sbjct: 67 NNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIR 126
Query: 137 AYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLS 196
+L+ L L N+IT V F ++ L L N + + + L +L L L+
Sbjct: 127 GLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLP-TLQALTLA 185
Query: 197 KNRITQLPVRAF-KLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNN--------- 246
N+I+ +P AF L L L L+ N+IR + F GL++LE L L NN
Sbjct: 186 LNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIK 245
Query: 247 --------------ISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSN 292
IS + DGAF G + +HL N L V + + + L+ LH L +
Sbjct: 246 ALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRG 305
Query: 293 NSIAR--------IHRKGW------------SFCQK---LHELVLSFNNLTRLDEESLAE 329
S+ + +H + + CQ+ L L LS+NN+ D S
Sbjct: 306 ASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIR--DLPSFNG 363
Query: 330 LSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTL 389
+L + L N I I EG F+GL SLR+LDL N I E S AF+ L ++ L +
Sbjct: 364 CHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIH---EIHSRAFATLGPITNLDV 420
Query: 390 FGNKIKSVAKRAFSGLEGLEHLNLGGN 416
N++ S GL GL L L GN
Sbjct: 421 SFNELTSFPT---EGLNGLNQLKLVGN 444
Score = 120 bits (300), Expect = 9e-27
Identities = 98/304 (32%), Positives = 135/304 (44%), Gaps = 25/304 (8%)
Query: 184 DGLSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKL 242
+GLS L +S N ITQLP AFK P L +L L N + I GL L+VL L
Sbjct: 53 EGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTL 112
Query: 243 QRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKG 302
Q N + + A GLS + L L+ N + V S GL L L L +NS+ +
Sbjct: 113 QNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHP 172
Query: 303 WSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDL 362
S L L L+ N ++ + + + LSSL VL L +N I +++ F GL +L LDL
Sbjct: 173 LSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDL 232
Query: 363 DHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQ 422
++N + + A L SL +L N I + AF G L ++L N + V
Sbjct: 233 NYNNLG----EFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVG 288
Query: 423 FDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTAT-CAHPES--LKGQSI 479
AF + +L L I S M+Q F T H ES L G I
Sbjct: 289 NSAFHNLSDLHSLVIRGAS-----------------MVQQFPNLTGTVHLESLTLTGTKI 331
Query: 480 FSVP 483
S+P
Sbjct: 332 SSIP 335
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 156 bits (395), Expect = 9e-38
Identities = 144/513 (28%), Positives = 216/513 (42%), Gaps = 43/513 (8%)
Query: 16 PCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNL 75
P LLW LL L A P PC C C + C LA +P D+P +T+++
Sbjct: 3 PGAWLLWTSLLLL------ARPAQPCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIF 56
Query: 76 SYNKLSEIDPAGFEDLPNLQEVYLNNNELTAV-PSLGAASSHVVSLFLQHNKIRSVEGSQ 134
+ ++ F PNL +V N +L P + L + + ++ +
Sbjct: 57 VETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNI 116
Query: 135 LKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLR 194
SL L L+ N + + F H ++ L+L GN++ L F L+ L TL
Sbjct: 117 FSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTH-LKTLN 175
Query: 195 LSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGA 254
L++N + QLP F L SL+ LKL N +S L G
Sbjct: 176 LAQNLLAQLPEELF-----------------------HPLTSLQTLKLSNNALSGLPQGV 212
Query: 255 FWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVL 314
F L + L L+ N++ E+ L L +L L N+I + ++ L L L
Sbjct: 213 FGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSL 272
Query: 315 SFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDT 374
+N L L A L L L+HN + +AEG F L +LR L L +N I+
Sbjct: 273 QWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHL---P 329
Query: 375 SGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKE 434
+G F L+ L KL L N + ++ F L LE L+L N + ++ F NL
Sbjct: 330 AGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFN 389
Query: 435 LHISSDSFLCDCQLKWLPPWL---IGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCD- 490
L + + + CDC L +L WL R+L + CA P LKGQ + ++ + VC
Sbjct: 390 LALHGNPWQCDCHLAYLFNWLQQYTDRLLN--IQTYCAGPAYLKGQVVPALNEKQLVCPV 447
Query: 491 --DFLKPQIITQPETTMAMVGKDIRFTCSAASS 521
D L Q +T P+ + A D+ AA S
Sbjct: 448 TRDHLGFQ-VTWPDESKAGGSWDLAVQERAARS 479
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 155 bits (392), Expect = 2e-37
Identities = 144/501 (28%), Positives = 219/501 (43%), Gaps = 64/501 (12%)
Query: 23 LLLLRLEPVTAAAGPRAP--CAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNLSYNKL 80
+L L L V A AP C A C+C+G ++DC G L ++P ++P T L+L+ N +
Sbjct: 8 MLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNI 67
Query: 81 SEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAAS--SHVVSLFLQHNKIRSVEGSQLKAY 138
+ I F L +L+ + L N+++ + GA + L L N ++
Sbjct: 68 TRITKTDFAGLRHLRVLQLMENKISTI-ERGAFQDLKELERLRLNRNHLQLFPELLFLGT 126
Query: 139 LSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKN 198
L LDLS N I + F IK L L N+I +E GAF L R L L L+ N
Sbjct: 127 AKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRAL-RDLEVLTLNNN 185
Query: 199 RITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWG 257
IT+L V +F +P+L L+ N + L + L QR + T
Sbjct: 186 NITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAW-----LSDWLRQRPRVGLYT------ 234
Query: 258 LSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFN 317
M HL +++ EV + + HQ ++ S + +H C N
Sbjct: 235 -QCMGPSHLRGHNVAEVQKREF--VCSGHQSFMA-PSCSVLHCPAACTCS---------N 281
Query: 318 NLTRLDEESLAEL-----SSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIE 372
N+ + L E+ +++ +RL N+I I GAF + LR +DL +N+IS
Sbjct: 282 NIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAP 341
Query: 373 DTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNL 432
D AF GL SL+ L L+GNKI + K F GL L+ L L N I ++ DAF + NL
Sbjct: 342 D---AFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNL 398
Query: 433 ------------------------KELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATC 468
+ +H++ + F+CDC LKWL +L ++ A C
Sbjct: 399 NLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIET-SGARC 457
Query: 469 AHPESLKGQSIFSVPPESFVC 489
P L + I + + F C
Sbjct: 458 TSPRRLANKRIGQIKSKKFRC 478
Score = 138 bits (347), Expect = 3e-32
Identities = 128/463 (27%), Positives = 198/463 (42%), Gaps = 33/463 (7%)
Query: 41 CAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLN 100
C AACTC+ + +DC G+GL +P +LP + L N + I P F L+ + L+
Sbjct: 273 CPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLS 332
Query: 101 NNELTAV-PSLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCF 159
NN+++ + P + SL L NKI + S + SL++L L+ N I +R F
Sbjct: 333 NNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAF 392
Query: 160 PHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLN 219
+ L+L N++ T+ G F L R++ T+ L++N + L L L+
Sbjct: 393 QDLHNLNLLSLYDNKLQTIAKGTFSPL-RAIQTMHLAQNPF----ICDCHLKWLADY-LH 446
Query: 220 RNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSL 279
N I G +L I ++ F +K SG
Sbjct: 447 TNPIET------SGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDC 500
Query: 280 YGLTALHQ--------LHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESL-AEL 330
+ A + + SN + +I Q EL L+ N T L+ + +L
Sbjct: 501 FADLACPEKCRCEGTTVDCSNQKLNKIPE---HIPQYTAELRLNNNEFTVLEATGIFKKL 557
Query: 331 SSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLF 390
L + S+N I+ I EGAF+G + + L N + F GL+SL L L
Sbjct: 558 PQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENV---QHKMFKGLESLKTLMLR 614
Query: 391 GNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKW 450
N+I V +F GL + L+L N I +V AF + +L L++ ++ F C+C L W
Sbjct: 615 SNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAW 674
Query: 451 LPPWLIGRMLQAFVTAT--CAHPESLKGQSIFSVPPESFVCDD 491
L WL + + VT C P LK I V + F CDD
Sbjct: 675 LGEWLRKKRI---VTGNPRCQKPYFLKEIPIQDVAIQDFTCDD 714
Score = 116 bits (290), Expect = 1e-25
Identities = 135/558 (24%), Positives = 229/558 (41%), Gaps = 88/558 (15%)
Query: 41 CAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAG-FEDLPNLQEVYL 99
C C C G ++DC + L +P +P +T L L+ N+ + ++ G F+ LP L+++
Sbjct: 506 CPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINF 565
Query: 100 NNNELTAVPSLGA--ASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNT 157
+NN++T + GA +S V + L N++ +V+ K SL+ L L N IT V N
Sbjct: 566 SNNKITDIEE-GAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGND 624
Query: 158 CFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLD 217
F ++ L+L N+I T+ GAFD L SL TL L N + L L
Sbjct: 625 SFIGLSSVRLLSLYDNQITTVAPGAFDTL-HSLSTLNLLANPFN---CNCY----LAWLG 676
Query: 218 LNRNRIRLIEG-LTFQGLNSLEVLKLQRNNISKLT------DGAFWGLSKMHVLHLEYNS 270
+ R++ G Q L+ + +Q I T D + LS+ ++
Sbjct: 677 EWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTECTCLDT 736
Query: 271 LVEVNSGSLYGLTA-----LHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEE 325
+V ++ L L + +L+L N + K S + L + LS N ++ L +
Sbjct: 737 VVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLV-PKELSNYKHLTLIDLSNNRISTLSNQ 795
Query: 326 SLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLS 385
S + ++ L L LS+N + I F GL+SLR+L L N+IS
Sbjct: 796 SFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDIS----------------- 838
Query: 386 KLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCD 445
V + AF+ L L HL +G N + CD
Sbjct: 839 ----------VVPEGAFNDLSALSHLAIGANPL------------------------YCD 864
Query: 446 CQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCDDFLKPQIITQPETTM 505
C ++WL W+ + + A CA P + + + + P + F C + I+ + +
Sbjct: 865 CNMQWLSDWVKSEYKEPGI-ARCAGPGEMADKLLLTTPSKKFTCQGPVDVNILAKCNPCL 923
Query: 506 AMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILHLR 565
+ K + + +S P+ F D + V +HA ++ HL+
Sbjct: 924 SNPCK------NDGTCNSDPVDFYRCTCPYGFKGQDCD--VPIHACISNPCKHGGTCHLK 975
Query: 566 QVTFGHEGRYQCVITNHF 583
+ G E + C+ + F
Sbjct: 976 E---GEEDGFWCICADGF 990
Score = 55.1 bits (131), Expect = 4e-07
Identities = 38/154 (24%), Positives = 62/154 (40%), Gaps = 24/154 (15%)
Query: 34 AAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPN 93
+ P + C CTC + C +GL LP +P +
Sbjct: 720 SCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPR------------------------D 755
Query: 94 LQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITE 153
+ E+YL+ N+ T VP + H+ + L +N+I ++ L L LS N +
Sbjct: 756 VTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRC 815
Query: 154 VRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLS 187
+ F ++ L+L GN I + GAF+ LS
Sbjct: 816 IPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLS 849
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 148 bits (374), Expect = 2e-35
Identities = 142/483 (29%), Positives = 223/483 (46%), Gaps = 29/483 (6%)
Query: 143 VLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQ 202
+L+LS N I + P ++EL+L+ N I +E GAF L R L LRL N++
Sbjct: 58 LLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPR-LRVLRLRGNQLKL 116
Query: 203 LPVRAF-KLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKM 261
+P F +L LT LDL+ N++ ++ TFQ L+SL L++ N++ ++ AF GL +
Sbjct: 117 IPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLAL 176
Query: 262 HVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTR 321
L LE +L ++ SL L +L L L + +IA + + + L L L +N
Sbjct: 177 EELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGL--LHLEIDNWPL 234
Query: 322 LDEESLAELSSLSVLRLS--HNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFS 379
L+E + L L++ LS H +I+ + A + L L+L HN IS G+F
Sbjct: 235 LEEVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTV---PRGSFR 291
Query: 380 GLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISS 439
L L +L L G + V +AF GL + LNL N + +++ F + L+ L +
Sbjct: 292 DLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDG 351
Query: 440 DSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPP----ESFVCDDFLKP 495
+ CDC+L W+ + A CA P ++G ++ ++P E FVC KP
Sbjct: 352 NPLACDCRLLWIVQRRKTLNFDGRLPA-CATPAEVRGDALRNLPDSVLFEYFVC---RKP 407
Query: 496 QIITQP-ETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGE 554
+I + + A G+D+RF C A + T AW A A
Sbjct: 408 KIRERRLQRVTATAGEDVRFLCRAEGEPAP--TVAWVTPQHRPVTA-------TSAGRAR 458
Query: 555 VMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTT 614
V+ T L ++ G Y CV +N G ++ A LTV P+ +TP + T
Sbjct: 459 VLPGGT-LEIQDARPQDSGTYTCVASN-AGGNDTYFATLTVRPEPAANRTPGEAHNETLA 516
Query: 615 MAR 617
R
Sbjct: 517 ALR 519
Score = 47.4 bits (111), Expect = 8e-05
Identities = 27/78 (34%), Positives = 37/78 (47%), Gaps = 1/78 (1%)
Query: 617 RLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQN 676
R C A G P P +AW A R V+P + I D + D+G Y+C A N
Sbjct: 426 RFLCRAEGEPAPTVAWVTPQHRPVTATSAGRARVLPGGTLE-IQDARPQDSGTYTCVASN 484
Query: 677 SAGSISANATLTVLETPS 694
+ G+ + ATLTV P+
Sbjct: 485 AGGNDTYFATLTVRPEPA 502
Score = 46.6 bits (109), Expect = 1e-04
Identities = 34/126 (26%), Positives = 54/126 (42%), Gaps = 9/126 (7%)
Query: 699 LEDRVVSVGETVALQCKATGNPPPRITWFKGD-RPLSLTE--RHHLTPDNQLLVVQNVVA 755
L+ + GE V C+A G P P + W RP++ T R + P L +Q+
Sbjct: 414 LQRVTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRARVLPGGTL-EIQDARP 472
Query: 756 EDAGRYTCEMSNTLGTERAHSQLSVLPAAGCRKDGTTVGIFTIAVVS-----SIVLTSLV 810
+D+G YTC SN G + + L+V P + T+A + + +L S
Sbjct: 473 QDSGTYTCVASNAGGNDTYFATLTVRPEPAANRTPGEAHNETLAALRAPLDLTTILVSTA 532
Query: 811 WVCIIY 816
CI +
Sbjct: 533 MGCITF 538
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 147 bits (372), Expect = 4e-35
Identities = 131/434 (30%), Positives = 206/434 (47%), Gaps = 22/434 (5%)
Query: 20 LLWLLLLRLEPVTAAAGPRAP-----CAAACTCAGDS-----LDCGGRGLAALPGDLPSW 69
+L L + L+ T + PR+ C C C D +DC GL+ LP +L +
Sbjct: 8 VLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVF 67
Query: 70 TRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVS-LFLQHNKIR 128
T L+LS N +S++ P L L+E+ L N LT +P + + L LQ+N++R
Sbjct: 68 TSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLR 127
Query: 129 SVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSR 188
V L+ SL+ L L N+I+ V +CF ++ L L N + + + AF LS
Sbjct: 128 HVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLS- 186
Query: 189 SLLTLRLSKNRITQLPVRAF-KLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNI 247
+L + L+ N+I +P AF L L L L+ NRI + F GL+SLE L L NN+
Sbjct: 187 ALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNL 246
Query: 248 SKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQ 307
+ A LS + L N++ + + G +L +H +N I + R +
Sbjct: 247 DEFPT-AIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLP 305
Query: 308 KLHELVLSFNNLTRLDE-ESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNE 366
+L L L N +++ E L ++L L L+ IS + + L +L+VLDL +N
Sbjct: 306 ELRTLTL--NGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYN- 362
Query: 367 ISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAF 426
+ED +FS L K+ L N+I + F L L LNL N I + +AF
Sbjct: 363 ---LLEDLP-SFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAF 418
Query: 427 VKMKNLKELHISSD 440
+ +L +L +SS+
Sbjct: 419 STLPSLIKLDLSSN 432
Score = 48.5 bits (114), Expect = 3e-05
Identities = 55/176 (31%), Positives = 79/176 (44%), Gaps = 23/176 (13%)
Query: 319 LTRLD--EESLAEL-SSLSV----LRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTI 371
L R+D + L+EL S+LSV L LS N+IS + LR L L L N ++
Sbjct: 47 LLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYI- 105
Query: 372 EDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKN 431
GAF+GL SL L L N+++ V A L L+ L L N I V F + +
Sbjct: 106 --PKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHS 163
Query: 432 LKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESF 487
L+ L +L D L +P +QAF + + +L I +P +F
Sbjct: 164 LRHL------WLDDNALTEIP-------VQAFRSLSALQAMTLALNKIHHIPDYAF 206
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 144 bits (362), Expect = 6e-34
Identities = 127/448 (28%), Positives = 205/448 (45%), Gaps = 73/448 (16%)
Query: 216 LDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVN 275
L+L+ N+I++I+ +F+ L LE+L+L RN+I + GAF GL+ ++ L L N L +
Sbjct: 81 LNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIP 140
Query: 276 SGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSV 335
+G+ L+ L +L L NN I I +FN + L L EL L
Sbjct: 141 NGAFVYLSKLKELWLRNNPIESIPS-------------YAFNRIPSLRRLDLGELKRL-- 185
Query: 336 LRLSHNSISHIAEGAFKGLRSLRVLD-----------------LDHNEISGTIEDT--SG 376
S+I+EGAF+GL +LR L+ LD ++SG G
Sbjct: 186 --------SYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPG 237
Query: 377 AFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELH 436
+F GL L KL + ++I+ + + AF L+ L +NL N + + D F + +L+ +H
Sbjct: 238 SFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIH 297
Query: 437 ISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAH---PESLKGQSIFSVPPESFVCDDFL 493
+ + + C+C + WL W+ + + TA CA P +LKG+ I + F C
Sbjct: 298 LHHNPWNCNCDILWLSWWI--KDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTC---Y 352
Query: 494 KPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDN-EVLTNADMENFVHVHAQD 552
P I+ P G C A++S +S +W N V+T+ + + V D
Sbjct: 353 APVIVEPPADLNVTEGMAAELKCRASTSLTS---VSWITPNGTVMTHGAYKVRIAV-LSD 408
Query: 553 GEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHD----I 608
G L+ VT G Y C+++N G+T A T+NV + T TP +
Sbjct: 409 G-------TLNFTNVTVQDTGMYTCMVSNSVGNT---TASATLNVTAA-TTTPFSYFSTV 457
Query: 609 TIRTTTMARLECAATGH---PNPQIAWQ 633
T+ T ++ E T + P P + W+
Sbjct: 458 TVETMEPSQDEARTTDNNVGPTPVVDWE 485
Score = 92.0 bits (227), Expect = 3e-18
Identities = 75/230 (32%), Positives = 111/230 (48%), Gaps = 5/230 (2%)
Query: 114 SSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGN 173
S++ L L N+I+ ++ + K LE+L LS N+I + F + L L N
Sbjct: 75 STNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDN 134
Query: 174 RIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAF-KLPRLTQLDLNR-NRIRLIEGLTF 231
R+ T+ GAF LS+ L L L N I +P AF ++P L +LDL R+ I F
Sbjct: 135 RLTTIPNGAFVYLSK-LKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAF 193
Query: 232 QGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLS 291
+GL++L L L N+ ++ + L K+ L L N L + GS GL L +L +
Sbjct: 194 EGLSNLRYLNLAMCNLREIPN--LTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMI 251
Query: 292 NNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHN 341
+ I I R + Q L E+ L+ NNLT L + L L + L HN
Sbjct: 252 QSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHN 301
Score = 48.1 bits (113), Expect = 4e-05
Identities = 41/145 (28%), Positives = 64/145 (44%), Gaps = 11/145 (7%)
Query: 599 PSFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFP-AARERRMHVMPDDDVF 657
P + P D+ + A L+C A+ ++W GT A + R+ V+ D +
Sbjct: 354 PVIVEPPADLNVTEGMAAELKCRASTSLT-SVSWITPNGTVMTHGAYKVRIAVLSDGTLN 412
Query: 658 FITDVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLVVP---LEDRVVSVGETVALQC 714
F T+V + D G+Y+C NS G+ +A+ATL V T + P V E +
Sbjct: 413 F-TNVTVQDTGMYTCMVSNSVGNTTASATLNV--TAATTTPFSYFSTVTVETMEPSQDEA 469
Query: 715 KATGN---PPPRITWFKGDRPLSLT 736
+ T N P P + W + SLT
Sbjct: 470 RTTDNNVGPTPVVDWETTNVTTSLT 494
Score = 35.8 bits (81), Expect = 0.23
Identities = 25/94 (26%), Positives = 44/94 (46%), Gaps = 4/94 (4%)
Query: 693 PSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLSLTERHHL---TPDNQLLV 749
P +V P D V+ G L+C+A+ + ++W + + + + + L
Sbjct: 354 PVIVEPPADLNVTEGMAAELKCRASTSLTS-VSWITPNGTVMTHGAYKVRIAVLSDGTLN 412
Query: 750 VQNVVAEDAGRYTCEMSNTLGTERAHSQLSVLPA 783
NV +D G YTC +SN++G A + L+V A
Sbjct: 413 FTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAA 446
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 142 bits (358), Expect = 2e-33
Identities = 97/296 (32%), Positives = 134/296 (45%), Gaps = 26/296 (8%)
Query: 493 LKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQD 552
L+ P M VG+ C P T +WKKD L + D + +
Sbjct: 129 LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEP-TISWKKDGSPLDDKDER----ITIRG 183
Query: 553 GEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRT 612
G++M I + R+ G+Y CV TN G S A LTV PSF K P ++ +
Sbjct: 184 GKLM----ITYTRK---SDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV 236
Query: 613 TTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSC 672
A +C A G P P + W+KD G + P +R + + DD I V D G Y+C
Sbjct: 237 DDSAEFKCEARGDPVPTVRWRKDDG-ELPKSR----YEIRDDHTLKIRKVTAGDMGSYTC 291
Query: 673 TAQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFK---- 728
A+N G A+ATLTV E P VV D+VV++G TV QC+ATGNP P I W +
Sbjct: 292 VAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQ 351
Query: 729 ----GDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
+P + R ++ L + NV D G Y C+ N G+ + L V
Sbjct: 352 NLLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 406
Score = 120 bits (301), Expect = 7e-27
Identities = 90/295 (30%), Positives = 132/295 (44%), Gaps = 15/295 (5%)
Query: 490 DDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNE-VLTNADMENFVHV 548
+DF P+I+ P + G+ C A + T W K E V T+ D +
Sbjct: 25 EDF-PPRIVEHPSDLIVSKGEPATLNCKAEGRPTP--TIEWYKGGERVETDKDDPRSHRM 81
Query: 549 HAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVL-PSFTKTPHD 607
G + + I+H R+ + EG Y CV N+ G SH A L V +L F + P D
Sbjct: 82 LLPSGSLF-FLRIVHGRK-SRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD 139
Query: 608 ITIRTTTMARLEC-AATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDD 666
+ + A +EC GHP P I+W+KDG ++ + IT + D
Sbjct: 140 VMVAVGEPAVMECQPPRGHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKSD 195
Query: 667 AGVYSCTAQNSAGSISAN-ATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRIT 725
AG Y C N G + A LTVLE PS V + V+V ++ +C+A G+P P +
Sbjct: 196 AGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVR 255
Query: 726 WFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
W K D L + + D+ L ++ V A D G YTC N +G A + L+V
Sbjct: 256 WRKDDG--ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Score = 109 bits (272), Expect = 2e-23
Identities = 84/288 (29%), Positives = 116/288 (40%), Gaps = 27/288 (9%)
Query: 494 KPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDG 553
+P + +P V F C A T W+KD+ L + E
Sbjct: 222 RPSFVKRPSNLAVTVDDSAEFKCEARGDPVP--TVRWRKDDGELPKSRYE---------- 269
Query: 554 EVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTT 613
+ L +R+VT G G Y CV N G + A LTV P F P D +
Sbjct: 270 --IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEA-SATLTVQEPPHFVVKPRDQVVALG 326
Query: 614 TMARLECAATGHPNPQIAWQKDGGTDF-----PAARERRMHVMPDDDVFFITDVKIDDAG 668
+C ATG+P P I W+++G + P R V D+ IT+V+ D G
Sbjct: 327 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITNVQRSDVG 385
Query: 669 VYSCTAQNSAGSISANATLTVLET------PSLVVPLEDRVVSVGETVALQCKATGNPPP 722
Y C N AGSI A L V + P + ++ V+V T L C ATG+P P
Sbjct: 386 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVP 445
Query: 723 RITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLG 770
I W K +S + +N +L ++ D GRYTC S G
Sbjct: 446 TILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG 493
Score = 82.0 bits (201), Expect = 3e-15
Identities = 64/200 (32%), Positives = 94/200 (47%), Gaps = 25/200 (12%)
Query: 599 PSFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDG---GTDFPAARERRMHVMPDDD 655
P + P D+ + A L C A G P P I W K G TD R RM ++P
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGS 87
Query: 656 VFFITDV----KIDDAGVYSCTAQNSAG-SISANATLTVL-------ETPSLVVPLEDRV 703
+FF+ V D GVY C A+N G ++S NA+L V + PS D +
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS------DVM 141
Query: 704 VSVGETVALQCK-ATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYT 762
V+VGE ++C+ G+P P I+W K PL + +T L++ DAG+Y
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITIRGGKLMITYTRKSDAGKYV 200
Query: 763 CEMSNTLGTERAH-SQLSVL 781
C +N +G + ++L+VL
Sbjct: 201 CVGTNMVGERESEVAELTVL 220
Score = 54.3 bits (129), Expect = 6e-07
Identities = 50/203 (24%), Positives = 87/203 (42%), Gaps = 15/203 (7%)
Query: 495 PQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGE 554
P + +P + +G+ + F C A + + P F W+++ + + ++ +
Sbjct: 312 PHFVVKPRDQVVALGRTVTFQCEA-TGNPQPAIF-WRREG---SQNLLFSYQPPQSSSRF 366
Query: 555 VMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVL------PSFTKTPHDI 608
+ T L + V G Y C N GS + KA L V + P + P +
Sbjct: 367 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIIT-KAYLEVTDVIADRPPPVIRQGPVNQ 425
Query: 609 TIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAG 668
T+ L C ATG P P I W+KDG + ++ R+ + ++ V I K+ D G
Sbjct: 426 TVAVDGTFVLSCVATGSPVPTILWRKDGV--LVSTQDSRIKQL-ENGVLQIRYAKLGDTG 482
Query: 669 VYSCTAQNSAGSISANATLTVLE 691
Y+C A +G + +A + V E
Sbjct: 483 RYTCIASTPSGEATWSAYIEVQE 505
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 142 bits (358), Expect = 2e-33
Identities = 97/296 (32%), Positives = 134/296 (45%), Gaps = 26/296 (8%)
Query: 493 LKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQD 552
L+ P M VG+ C P T +WKKD L + D + +
Sbjct: 168 LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEP-TISWKKDGSPLDDKDER----ITIRG 222
Query: 553 GEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRT 612
G++M I + R+ G+Y CV TN G S A LTV PSF K P ++ +
Sbjct: 223 GKLM----ITYTRK---SDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV 275
Query: 613 TTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSC 672
A +C A G P P + W+KD G + P +R + + DD I V D G Y+C
Sbjct: 276 DDSAEFKCEARGDPVPTVRWRKDDG-ELPKSR----YEIRDDHTLKIRKVTAGDMGSYTC 330
Query: 673 TAQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFK---- 728
A+N G A+ATLTV E P VV D+VV++G TV QC+ATGNP P I W +
Sbjct: 331 VAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQ 390
Query: 729 ----GDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
+P + R ++ L + NV D G Y C+ N G+ + L V
Sbjct: 391 NLLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 445
Score = 120 bits (301), Expect = 7e-27
Identities = 90/295 (30%), Positives = 132/295 (44%), Gaps = 15/295 (5%)
Query: 490 DDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNE-VLTNADMENFVHV 548
+DF P+I+ P + G+ C A + T W K E V T+ D +
Sbjct: 64 EDF-PPRIVEHPSDLIVSKGEPATLNCKAEGRPTP--TIEWYKGGERVETDKDDPRSHRM 120
Query: 549 HAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVL-PSFTKTPHD 607
G + + I+H R+ + EG Y CV N+ G SH A L V +L F + P D
Sbjct: 121 LLPSGSLF-FLRIVHGRK-SRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD 178
Query: 608 ITIRTTTMARLEC-AATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDD 666
+ + A +EC GHP P I+W+KDG ++ + IT + D
Sbjct: 179 VMVAVGEPAVMECQPPRGHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKSD 234
Query: 667 AGVYSCTAQNSAGSISAN-ATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRIT 725
AG Y C N G + A LTVLE PS V + V+V ++ +C+A G+P P +
Sbjct: 235 AGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVR 294
Query: 726 WFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
W K D L + + D+ L ++ V A D G YTC N +G A + L+V
Sbjct: 295 WRKDDG--ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 347
Score = 109 bits (272), Expect = 2e-23
Identities = 84/288 (29%), Positives = 116/288 (40%), Gaps = 27/288 (9%)
Query: 494 KPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDG 553
+P + +P V F C A T W+KD+ L + E
Sbjct: 261 RPSFVKRPSNLAVTVDDSAEFKCEARGDPVP--TVRWRKDDGELPKSRYE---------- 308
Query: 554 EVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTT 613
+ L +R+VT G G Y CV N G + A LTV P F P D +
Sbjct: 309 --IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEA-SATLTVQEPPHFVVKPRDQVVALG 365
Query: 614 TMARLECAATGHPNPQIAWQKDGGTDF-----PAARERRMHVMPDDDVFFITDVKIDDAG 668
+C ATG+P P I W+++G + P R V D+ IT+V+ D G
Sbjct: 366 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITNVQRSDVG 424
Query: 669 VYSCTAQNSAGSISANATLTVLET------PSLVVPLEDRVVSVGETVALQCKATGNPPP 722
Y C N AGSI A L V + P + ++ V+V T L C ATG+P P
Sbjct: 425 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVP 484
Query: 723 RITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLG 770
I W K +S + +N +L ++ D GRYTC S G
Sbjct: 485 TILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG 532
Score = 82.0 bits (201), Expect = 3e-15
Identities = 64/200 (32%), Positives = 94/200 (47%), Gaps = 25/200 (12%)
Query: 599 PSFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDG---GTDFPAARERRMHVMPDDD 655
P + P D+ + A L C A G P P I W K G TD R RM ++P
Sbjct: 68 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGS 126
Query: 656 VFFITDV----KIDDAGVYSCTAQNSAG-SISANATLTVL-------ETPSLVVPLEDRV 703
+FF+ V D GVY C A+N G ++S NA+L V + PS D +
Sbjct: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS------DVM 180
Query: 704 VSVGETVALQCK-ATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYT 762
V+VGE ++C+ G+P P I+W K PL + +T L++ DAG+Y
Sbjct: 181 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITIRGGKLMITYTRKSDAGKYV 239
Query: 763 CEMSNTLGTERAH-SQLSVL 781
C +N +G + ++L+VL
Sbjct: 240 CVGTNMVGERESEVAELTVL 259
Score = 54.3 bits (129), Expect = 6e-07
Identities = 50/203 (24%), Positives = 87/203 (42%), Gaps = 15/203 (7%)
Query: 495 PQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGE 554
P + +P + +G+ + F C A + + P F W+++ + + ++ +
Sbjct: 351 PHFVVKPRDQVVALGRTVTFQCEA-TGNPQPAIF-WRREG---SQNLLFSYQPPQSSSRF 405
Query: 555 VMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVL------PSFTKTPHDI 608
+ T L + V G Y C N GS + KA L V + P + P +
Sbjct: 406 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIIT-KAYLEVTDVIADRPPPVIRQGPVNQ 464
Query: 609 TIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAG 668
T+ L C ATG P P I W+KDG + ++ R+ + ++ V I K+ D G
Sbjct: 465 TVAVDGTFVLSCVATGSPVPTILWRKDGV--LVSTQDSRIKQL-ENGVLQIRYAKLGDTG 521
Query: 669 VYSCTAQNSAGSISANATLTVLE 691
Y+C A +G + +A + V E
Sbjct: 522 RYTCIASTPSGEATWSAYIEVQE 544
Score = 48.9 bits (115), Expect = 3e-05
Identities = 38/123 (30%), Positives = 51/123 (41%), Gaps = 11/123 (8%)
Query: 665 DDAGVYSCTAQNSAGSISANATLTVLET--PSLVVPLEDRVVSVGETVALQCKATGNPPP 722
+D G T+ N S+ + E P +V D +VS GE L CKA G P P
Sbjct: 38 NDHGTPIPTSDNDDNSLGYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTP 97
Query: 723 RITWFKGDRPLSLTE---RHH--LTPDNQLLVVQNVVAE----DAGRYTCEMSNTLGTER 773
I W+KG + + R H L P L ++ V D G Y C N LG
Sbjct: 98 TIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV 157
Query: 774 AHS 776
+H+
Sbjct: 158 SHN 160
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 142 bits (357), Expect = 2e-33
Identities = 112/338 (33%), Positives = 163/338 (48%), Gaps = 32/338 (9%)
Query: 168 LNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAF-KLPRLTQLDLNRNRIRLI 226
L L GN I + GL SL+ L L + I + +AF +L L L LN N I+ +
Sbjct: 65 LYLTGNNISYINESELTGL-HSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRL 123
Query: 227 EGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALH 286
+ F+GL +L L LQ N +S + G F L + L+L+ N L + SG+ G+ AL
Sbjct: 124 DPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALR 183
Query: 287 QLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHI 346
L LSNN+I RI G+ + L L L NNLT++ + L SL L LSHN I I
Sbjct: 184 ILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAI 243
Query: 347 AEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLE 406
AFKGL +L L L ++ I D FSG+++L L L N ++++ FS L+
Sbjct: 244 QPFAFKGLANLEYLLLKNSRIRNVTRD---GFSGINNLKHLILSHNDLENLNSDTFSLLK 300
Query: 407 GLEHLNLGGNAIRSVQFDAFVKM-----------KNLKELH--------------ISSDS 441
L +L L N I S+ D F M NL LH +S+
Sbjct: 301 NLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNP 360
Query: 442 FLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSI 479
+ C+C+L L WL + + C +P S++G+++
Sbjct: 361 WECNCKLLGLRDWLASSAIT--LNIYCQNPPSMRGRAL 396
Score = 131 bits (329), Expect = 4e-30
Identities = 106/361 (29%), Positives = 168/361 (46%), Gaps = 39/361 (10%)
Query: 16 PCLLLL-----WLLLLRLEPVTAAAGPRAPCAAACT-CAGDSLDCGGRGLAALPGDLPSW 69
PCL L +LLLL + + C++ C C G ++C GL+++P + P
Sbjct: 9 PCLRLFLVVTCYLLLLLHKEILG-------CSSVCQLCTGRQINCRNLGLSSIPKNFPES 61
Query: 70 TRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAV-PSLGAASSHVVSLFLQHNKIR 128
T L L+ N +S I+ + L +L +YL+N+ + V P H+ LFL +N I+
Sbjct: 62 TVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIK 121
Query: 129 SVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSR 188
++ K L+L L L N ++ V F ++ LNL NR+ L G F G
Sbjct: 122 RLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVG--- 178
Query: 189 SLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNIS 248
++ LR+ LDL+ N I I FQ L +L L L NN++
Sbjct: 179 -MVALRI--------------------LDLSNNNILRISESGFQHLENLACLYLGSNNLT 217
Query: 249 KLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQK 308
K+ AF L + L L +N + + + GL L L L N+ I + R G+S
Sbjct: 218 KVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINN 277
Query: 309 LHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGL-RSLRVLDLDHNEI 367
L L+LS N+L L+ ++ + L +L L+L N I I F+ + SL++L+L N +
Sbjct: 278 LKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNL 337
Query: 368 S 368
+
Sbjct: 338 T 338
>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
Length = 653
Score = 137 bits (346), Expect = 4e-32
Identities = 126/439 (28%), Positives = 192/439 (43%), Gaps = 67/439 (15%)
Query: 216 LDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVN 275
L+L N I++I+ TF+ L+ LEVL+L RN+I ++ GAF GL+ ++ L L N L +
Sbjct: 80 LNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIP 139
Query: 276 SGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSV 335
SG+ L+ L +L L NN I I +FN + L L EL L
Sbjct: 140 SGAFEYLSKLRELWLRNNPIESIPS-------------YAFNRVPSLMRLDLGELKKL-- 184
Query: 336 LRLSHNSISHIAEGAFKGLRSLRVLD-----------------LDHNEISGT--IEDTSG 376
+I+EGAF+GL +L+ L+ L+ E+SG E G
Sbjct: 185 --------EYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPG 236
Query: 377 AFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELH 436
+F GL SL KL + +++ + + AF GL L LNL N + S+ D F ++ L ELH
Sbjct: 237 SFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELH 296
Query: 437 ISSDSFLCDCQLKWLPPWLIGRM-LQAFVTATCAHPESLKGQSIFSVPPESFVCDDFLKP 495
+ + + CDC + WL WL + + C P ++G+ + V SF C P
Sbjct: 297 LHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCS---AP 353
Query: 496 QIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDN-EVLTNADMENFVHVHAQDGE 554
I+ P G+ C SS W N VL++A + V DG
Sbjct: 354 FIMDAPRDLNISEGRMAELKCRTPPMSS----VKWLLPNGTVLSHASRHPRISV-LNDG- 407
Query: 555 VMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPH-----DIT 609
L+ V G Y C++TN G++ A +NV + T + +T
Sbjct: 408 ------TLNFSHVLLSDTGVYTCMVTNVAGNS---NASAYLNVSTAELNTSNYSFFTTVT 458
Query: 610 IRTTTMARLECAATGHPNP 628
+ TT ++ + P P
Sbjct: 459 VETTEISPEDTTRKYKPVP 477
Score = 88.2 bits (217), Expect = 4e-17
Identities = 79/279 (28%), Positives = 131/279 (46%), Gaps = 12/279 (4%)
Query: 21 LWLLLLRLEPVTAAAGPRAPCAAACTCAGD--SLDCGGRGLAALPGDLPSWTRSLNLSYN 78
+W+L + A+AGP+ C + C+C+ + C RGL+ +P +PS TR LNL N
Sbjct: 28 VWILCAAIA-AAASAGPQN-CPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMEN 85
Query: 79 KLSEIDPAGFEDLPNLQEVYLNNNELTAV---PSLGAASSHVVSLFLQHNKIRSVEGSQL 135
+ I F L +L+ + L N + + G AS + + LF N + +
Sbjct: 86 NIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELF--DNWLTVIPSGAF 143
Query: 136 KAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAG-NRIGTLELGAFDGLSRSLLTLR 194
+ L L L N I + + F P + L+L ++ + GAF+GL +L L
Sbjct: 144 EYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLF-NLKYLN 202
Query: 195 LSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGA 254
L I +P L L +L+++ N I +F GL+SL+ L + + +S + A
Sbjct: 203 LGMCNIKDMP-NLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNA 261
Query: 255 FWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNN 293
F GL+ + L+L +N+L + L L +LHL +N
Sbjct: 262 FDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHN 300
Score = 54.7 bits (130), Expect = 5e-07
Identities = 76/302 (25%), Positives = 117/302 (38%), Gaps = 50/302 (16%)
Query: 599 PSFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFP-AARERRMHVMPDDDVF 657
P P D+ I MA L+C P + W GT A+R R+ V+ D +
Sbjct: 353 PFIMDAPRDLNISEGRMAELKCRTP--PMSSVKWLLPNGTVLSHASRHPRISVLNDGTLN 410
Query: 658 FITDVKIDDAGVYSCTAQNSAGSISANATLTV----LETPS----LVVPLEDRVVSVGET 709
F + V + D GVY+C N AG+ +A+A L V L T + V +E +S +T
Sbjct: 411 F-SHVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEISPEDT 469
Query: 710 VALQCKATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTL 769
T P T G +P T L Q V VA A T +M +L
Sbjct: 470 -------TRKYKPVPTTSTGYQPAYTTSTTVLI---QTTRVPKQVAVPATDTTDKMQTSL 519
Query: 770 GTERAHSQLSVLPAAGCRKDGTTVGIFTIAVVSSIVLTSLVWVCIIYQTRKKSEEYSVTN 829
+++ + GC ++ L + + + Y+ RK+ ++ S
Sbjct: 520 DEVMKTTKIII----GC--------------FVAVTLLAAAMLIVFYKLRKRHQQRSTVT 561
Query: 830 TDETV----VPPDVPSYLSSQGTLSDRQETVVRTEGG---PQANGHIESNGVCPRDASHF 882
TV V D+P+ S+ T + + V EG P + HI N P +H+
Sbjct: 562 AARTVEIIQVDEDIPAATSAAATAA---PSGVSGEGAVVLPTIHDHINYNTYKPAHGAHW 618
Query: 883 PE 884
E
Sbjct: 619 TE 620
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 137 bits (344), Expect = 7e-32
Identities = 97/299 (32%), Positives = 134/299 (44%), Gaps = 29/299 (9%)
Query: 493 LKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQD 552
L+ P M VG+ C P T +WKKD L + D + +
Sbjct: 129 LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEP-TISWKKDGSPLDDKDER----ITIRG 183
Query: 553 GEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRT 612
G++M I + R+ G+Y CV TN G S A LTV PSF K P ++ +
Sbjct: 184 GKLM----ITYTRK---SDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV 236
Query: 613 TTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSC 672
A +C A G P P + W+KD G + P +R + + DD I V D G Y+C
Sbjct: 237 DDSAEFKCEARGDPVPTVRWRKDDG-ELPKSR----YEIRDDHTLKIRKVTAGDMGSYTC 291
Query: 673 TAQNSAGSISANATLTV---LETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFK- 728
A+N G A+ATLTV E P VV D+VV++G TV QC+ATGNP P I W +
Sbjct: 292 VAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRRE 351
Query: 729 -------GDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
+P + R ++ L + NV D G Y C+ N G+ + L V
Sbjct: 352 GSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 409
Score = 120 bits (301), Expect = 7e-27
Identities = 90/295 (30%), Positives = 132/295 (44%), Gaps = 15/295 (5%)
Query: 490 DDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNE-VLTNADMENFVHV 548
+DF P+I+ P + G+ C A + T W K E V T+ D +
Sbjct: 25 EDF-PPRIVEHPSDLIVSKGEPATLNCKAEGRPTP--TIEWYKGGERVETDKDDPRSHRM 81
Query: 549 HAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVL-PSFTKTPHD 607
G + + I+H R+ + EG Y CV N+ G SH A L V +L F + P D
Sbjct: 82 LLPSGSLF-FLRIVHGRK-SRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD 139
Query: 608 ITIRTTTMARLEC-AATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDD 666
+ + A +EC GHP P I+W+KDG ++ + IT + D
Sbjct: 140 VMVAVGEPAVMECQPPRGHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKSD 195
Query: 667 AGVYSCTAQNSAGSISAN-ATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRIT 725
AG Y C N G + A LTVLE PS V + V+V ++ +C+A G+P P +
Sbjct: 196 AGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVR 255
Query: 726 WFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
W K D L + + D+ L ++ V A D G YTC N +G A + L+V
Sbjct: 256 WRKDDG--ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Score = 106 bits (264), Expect = 1e-22
Identities = 85/291 (29%), Positives = 117/291 (40%), Gaps = 30/291 (10%)
Query: 494 KPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDG 553
+P + +P V F C A T W+KD+ L + E
Sbjct: 222 RPSFVKRPSNLAVTVDDSAEFKCEARGDPVP--TVRWRKDDGELPKSRYE---------- 269
Query: 554 EVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNV---LPSFTKTPHDITI 610
+ L +R+VT G G Y CV N G + A LTV V P F P D +
Sbjct: 270 --IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEA-SATLTVQVGSEPPHFVVKPRDQVV 326
Query: 611 RTTTMARLECAATGHPNPQIAWQKDGGTDF-----PAARERRMHVMPDDDVFFITDVKID 665
+C ATG+P P I W+++G + P R V D+ IT+V+
Sbjct: 327 ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITNVQRS 385
Query: 666 DAGVYSCTAQNSAGSISANATLTVLET------PSLVVPLEDRVVSVGETVALQCKATGN 719
D G Y C N AGSI A L V + P + ++ V+V T L C ATG+
Sbjct: 386 DVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGS 445
Query: 720 PPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLG 770
P P I W K +S + +N +L ++ D GRYTC S G
Sbjct: 446 PVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG 496
Score = 82.0 bits (201), Expect = 3e-15
Identities = 64/200 (32%), Positives = 94/200 (47%), Gaps = 25/200 (12%)
Query: 599 PSFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDG---GTDFPAARERRMHVMPDDD 655
P + P D+ + A L C A G P P I W K G TD R RM ++P
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGS 87
Query: 656 VFFITDV----KIDDAGVYSCTAQNSAG-SISANATLTVL-------ETPSLVVPLEDRV 703
+FF+ V D GVY C A+N G ++S NA+L V + PS D +
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS------DVM 141
Query: 704 VSVGETVALQCK-ATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYT 762
V+VGE ++C+ G+P P I+W K PL + +T L++ DAG+Y
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITIRGGKLMITYTRKSDAGKYV 200
Query: 763 CEMSNTLGTERAH-SQLSVL 781
C +N +G + ++L+VL
Sbjct: 201 CVGTNMVGERESEVAELTVL 220
Score = 54.3 bits (129), Expect = 6e-07
Identities = 50/203 (24%), Positives = 87/203 (42%), Gaps = 15/203 (7%)
Query: 495 PQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGE 554
P + +P + +G+ + F C A + + P F W+++ + + ++ +
Sbjct: 315 PHFVVKPRDQVVALGRTVTFQCEA-TGNPQPAIF-WRREG---SQNLLFSYQPPQSSSRF 369
Query: 555 VMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVL------PSFTKTPHDI 608
+ T L + V G Y C N GS + KA L V + P + P +
Sbjct: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIIT-KAYLEVTDVIADRPPPVIRQGPVNQ 428
Query: 609 TIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAG 668
T+ L C ATG P P I W+KDG + ++ R+ + ++ V I K+ D G
Sbjct: 429 TVAVDGTFVLSCVATGSPVPTILWRKDGV--LVSTQDSRIKQL-ENGVLQIRYAKLGDTG 485
Query: 669 VYSCTAQNSAGSISANATLTVLE 691
Y+C A +G + +A + V E
Sbjct: 486 RYTCIASTPSGEATWSAYIEVQE 508
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 137 bits (344), Expect = 7e-32
Identities = 97/299 (32%), Positives = 134/299 (44%), Gaps = 29/299 (9%)
Query: 493 LKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQD 552
L+ P M VG+ C P T +WKKD L + D + +
Sbjct: 129 LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEP-TISWKKDGSPLDDKDER----ITIRG 183
Query: 553 GEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRT 612
G++M I + R+ G+Y CV TN G S A LTV PSF K P ++ +
Sbjct: 184 GKLM----ITYTRK---SDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV 236
Query: 613 TTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSC 672
A +C A G P P + W+KD G + P +R + + DD I V D G Y+C
Sbjct: 237 DDSAEFKCEARGDPVPTVRWRKDDG-ELPKSR----YEIRDDHTLKIRKVTAGDMGSYTC 291
Query: 673 TAQNSAGSISANATLTV---LETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFK- 728
A+N G A+ATLTV E P VV D+VV++G TV QC+ATGNP P I W +
Sbjct: 292 VAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRRE 351
Query: 729 -------GDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
+P + R ++ L + NV D G Y C+ N G+ + L V
Sbjct: 352 GSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 409
Score = 120 bits (301), Expect = 7e-27
Identities = 90/295 (30%), Positives = 132/295 (44%), Gaps = 15/295 (5%)
Query: 490 DDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNE-VLTNADMENFVHV 548
+DF P+I+ P + G+ C A + T W K E V T+ D +
Sbjct: 25 EDF-PPRIVEHPSDLIVSKGEPATLNCKAEGRPTP--TIEWYKGGERVETDKDDPRSHRM 81
Query: 549 HAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVL-PSFTKTPHD 607
G + + I+H R+ + EG Y CV N+ G SH A L V +L F + P D
Sbjct: 82 LLPSGSLF-FLRIVHGRK-SRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD 139
Query: 608 ITIRTTTMARLEC-AATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDD 666
+ + A +EC GHP P I+W+KDG ++ + IT + D
Sbjct: 140 VMVAVGEPAVMECQPPRGHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKSD 195
Query: 667 AGVYSCTAQNSAGSISAN-ATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRIT 725
AG Y C N G + A LTVLE PS V + V+V ++ +C+A G+P P +
Sbjct: 196 AGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVR 255
Query: 726 WFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
W K D L + + D+ L ++ V A D G YTC N +G A + L+V
Sbjct: 256 WRKDDG--ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Score = 106 bits (264), Expect = 1e-22
Identities = 85/291 (29%), Positives = 117/291 (40%), Gaps = 30/291 (10%)
Query: 494 KPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDG 553
+P + +P V F C A T W+KD+ L + E
Sbjct: 222 RPSFVKRPSNLAVTVDDSAEFKCEARGDPVP--TVRWRKDDGELPKSRYE---------- 269
Query: 554 EVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNV---LPSFTKTPHDITI 610
+ L +R+VT G G Y CV N G + A LTV V P F P D +
Sbjct: 270 --IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEA-SATLTVQVGSEPPHFVVKPRDQVV 326
Query: 611 RTTTMARLECAATGHPNPQIAWQKDGGTDF-----PAARERRMHVMPDDDVFFITDVKID 665
+C ATG+P P I W+++G + P R V D+ IT+V+
Sbjct: 327 ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITNVQRS 385
Query: 666 DAGVYSCTAQNSAGSISANATLTVLET------PSLVVPLEDRVVSVGETVALQCKATGN 719
D G Y C N AGSI A L V + P + ++ V+V T L C ATG+
Sbjct: 386 DVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGS 445
Query: 720 PPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLG 770
P P I W K +S + +N +L ++ D GRYTC S G
Sbjct: 446 PVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG 496
Score = 82.0 bits (201), Expect = 3e-15
Identities = 64/200 (32%), Positives = 94/200 (47%), Gaps = 25/200 (12%)
Query: 599 PSFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDG---GTDFPAARERRMHVMPDDD 655
P + P D+ + A L C A G P P I W K G TD R RM ++P
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGS 87
Query: 656 VFFITDV----KIDDAGVYSCTAQNSAG-SISANATLTVL-------ETPSLVVPLEDRV 703
+FF+ V D GVY C A+N G ++S NA+L V + PS D +
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS------DVM 141
Query: 704 VSVGETVALQCK-ATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYT 762
V+VGE ++C+ G+P P I+W K PL + +T L++ DAG+Y
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITIRGGKLMITYTRKSDAGKYV 200
Query: 763 CEMSNTLGTERAH-SQLSVL 781
C +N +G + ++L+VL
Sbjct: 201 CVGTNMVGERESEVAELTVL 220
Score = 54.3 bits (129), Expect = 6e-07
Identities = 50/203 (24%), Positives = 87/203 (42%), Gaps = 15/203 (7%)
Query: 495 PQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGE 554
P + +P + +G+ + F C A + + P F W+++ + + ++ +
Sbjct: 315 PHFVVKPRDQVVALGRTVTFQCEA-TGNPQPAIF-WRREG---SQNLLFSYQPPQSSSRF 369
Query: 555 VMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVL------PSFTKTPHDI 608
+ T L + V G Y C N GS + KA L V + P + P +
Sbjct: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIIT-KAYLEVTDVIADRPPPVIRQGPVNQ 428
Query: 609 TIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAG 668
T+ L C ATG P P I W+KDG + ++ R+ + ++ V I K+ D G
Sbjct: 429 TVAVDGTFVLSCVATGSPVPTILWRKDGV--LVSTQDSRIKQL-ENGVLQIRYAKLGDTG 485
Query: 669 VYSCTAQNSAGSISANATLTVLE 691
Y+C A +G + +A + V E
Sbjct: 486 RYTCIASTPSGEATWSAYIEVQE 508
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 137 bits (344), Expect = 7e-32
Identities = 97/299 (32%), Positives = 134/299 (44%), Gaps = 29/299 (9%)
Query: 493 LKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQD 552
L+ P M VG+ C P T +WKKD L + D + +
Sbjct: 129 LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEP-TISWKKDGSPLDDKDER----ITIRG 183
Query: 553 GEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRT 612
G++M I + R+ G+Y CV TN G S A LTV PSF K P ++ +
Sbjct: 184 GKLM----ITYTRK---SDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV 236
Query: 613 TTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSC 672
A +C A G P P + W+KD G + P +R + + DD I V D G Y+C
Sbjct: 237 DDSAEFKCEARGDPVPTVRWRKDDG-ELPKSR----YEIRDDHTLKIRKVTAGDMGSYTC 291
Query: 673 TAQNSAGSISANATLTV---LETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFK- 728
A+N G A+ATLTV E P VV D+VV++G TV QC+ATGNP P I W +
Sbjct: 292 VAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRRE 351
Query: 729 -------GDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
+P + R ++ L + NV D G Y C+ N G+ + L V
Sbjct: 352 GSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 409
Score = 120 bits (301), Expect = 7e-27
Identities = 90/295 (30%), Positives = 132/295 (44%), Gaps = 15/295 (5%)
Query: 490 DDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNE-VLTNADMENFVHV 548
+DF P+I+ P + G+ C A + T W K E V T+ D +
Sbjct: 25 EDF-PPRIVEHPSDLIVSKGEPATLNCKAEGRPTP--TIEWYKGGERVETDKDDPRSHRM 81
Query: 549 HAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVL-PSFTKTPHD 607
G + + I+H R+ + EG Y CV N+ G SH A L V +L F + P D
Sbjct: 82 LLPSGSLF-FLRIVHGRK-SRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD 139
Query: 608 ITIRTTTMARLEC-AATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDD 666
+ + A +EC GHP P I+W+KDG ++ + IT + D
Sbjct: 140 VMVAVGEPAVMECQPPRGHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKSD 195
Query: 667 AGVYSCTAQNSAGSISAN-ATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRIT 725
AG Y C N G + A LTVLE PS V + V+V ++ +C+A G+P P +
Sbjct: 196 AGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVR 255
Query: 726 WFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
W K D L + + D+ L ++ V A D G YTC N +G A + L+V
Sbjct: 256 WRKDDG--ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Score = 106 bits (264), Expect = 1e-22
Identities = 85/291 (29%), Positives = 117/291 (40%), Gaps = 30/291 (10%)
Query: 494 KPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDG 553
+P + +P V F C A T W+KD+ L + E
Sbjct: 222 RPSFVKRPSNLAVTVDDSAEFKCEARGDPVP--TVRWRKDDGELPKSRYE---------- 269
Query: 554 EVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNV---LPSFTKTPHDITI 610
+ L +R+VT G G Y CV N G + A LTV V P F P D +
Sbjct: 270 --IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEA-SATLTVQVGSEPPHFVVKPRDQVV 326
Query: 611 RTTTMARLECAATGHPNPQIAWQKDGGTDF-----PAARERRMHVMPDDDVFFITDVKID 665
+C ATG+P P I W+++G + P R V D+ IT+V+
Sbjct: 327 ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITNVQRS 385
Query: 666 DAGVYSCTAQNSAGSISANATLTVLET------PSLVVPLEDRVVSVGETVALQCKATGN 719
D G Y C N AGSI A L V + P + ++ V+V T L C ATG+
Sbjct: 386 DVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGS 445
Query: 720 PPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLG 770
P P I W K +S + +N +L ++ D GRYTC S G
Sbjct: 446 PVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG 496
Score = 82.0 bits (201), Expect = 3e-15
Identities = 64/200 (32%), Positives = 94/200 (47%), Gaps = 25/200 (12%)
Query: 599 PSFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDG---GTDFPAARERRMHVMPDDD 655
P + P D+ + A L C A G P P I W K G TD R RM ++P
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGS 87
Query: 656 VFFITDV----KIDDAGVYSCTAQNSAG-SISANATLTVL-------ETPSLVVPLEDRV 703
+FF+ V D GVY C A+N G ++S NA+L V + PS D +
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS------DVM 141
Query: 704 VSVGETVALQCK-ATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYT 762
V+VGE ++C+ G+P P I+W K PL + +T L++ DAG+Y
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITIRGGKLMITYTRKSDAGKYV 200
Query: 763 CEMSNTLGTERAH-SQLSVL 781
C +N +G + ++L+VL
Sbjct: 201 CVGTNMVGERESEVAELTVL 220
Score = 54.3 bits (129), Expect = 6e-07
Identities = 50/203 (24%), Positives = 87/203 (42%), Gaps = 15/203 (7%)
Query: 495 PQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGE 554
P + +P + +G+ + F C A + + P F W+++ + + ++ +
Sbjct: 315 PHFVVKPRDQVVALGRTVTFQCEA-TGNPQPAIF-WRREG---SQNLLFSYQPPQSSSRF 369
Query: 555 VMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVL------PSFTKTPHDI 608
+ T L + V G Y C N GS + KA L V + P + P +
Sbjct: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIIT-KAYLEVTDVIADRPPPVIRQGPVNQ 428
Query: 609 TIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAG 668
T+ L C ATG P P I W+KDG + ++ R+ + ++ V I K+ D G
Sbjct: 429 TVAVDGTFVLSCVATGSPVPTILWRKDGV--LVSTQDSRIKQL-ENGVLQIRYAKLGDTG 485
Query: 669 VYSCTAQNSAGSISANATLTVLE 691
Y+C A +G + +A + V E
Sbjct: 486 RYTCIASTPSGEATWSAYIEVQE 508
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 137 bits (344), Expect = 7e-32
Identities = 97/299 (32%), Positives = 134/299 (44%), Gaps = 29/299 (9%)
Query: 493 LKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQD 552
L+ P M VG+ C P T +WKKD L + D + +
Sbjct: 129 LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEP-TISWKKDGSPLDDKDER----ITIRG 183
Query: 553 GEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRT 612
G++M I + R+ G+Y CV TN G S A LTV PSF K P ++ +
Sbjct: 184 GKLM----ITYTRK---SDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV 236
Query: 613 TTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSC 672
A +C A G P P + W+KD G + P +R + + DD I V D G Y+C
Sbjct: 237 DDSAEFKCEARGDPVPTVRWRKDDG-ELPKSR----YEIRDDHTLKIRKVTAGDMGSYTC 291
Query: 673 TAQNSAGSISANATLTV---LETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFK- 728
A+N G A+ATLTV E P VV D+VV++G TV QC+ATGNP P I W +
Sbjct: 292 VAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRRE 351
Query: 729 -------GDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
+P + R ++ L + NV D G Y C+ N G+ + L V
Sbjct: 352 GSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 409
Score = 120 bits (301), Expect = 7e-27
Identities = 90/295 (30%), Positives = 132/295 (44%), Gaps = 15/295 (5%)
Query: 490 DDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNE-VLTNADMENFVHV 548
+DF P+I+ P + G+ C A + T W K E V T+ D +
Sbjct: 25 EDF-PPRIVEHPSDLIVSKGEPATLNCKAEGRPTP--TIEWYKGGERVETDKDDPRSHRM 81
Query: 549 HAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVL-PSFTKTPHD 607
G + + I+H R+ + EG Y CV N+ G SH A L V +L F + P D
Sbjct: 82 LLPSGSLF-FLRIVHGRK-SRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD 139
Query: 608 ITIRTTTMARLEC-AATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDD 666
+ + A +EC GHP P I+W+KDG ++ + IT + D
Sbjct: 140 VMVAVGEPAVMECQPPRGHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKSD 195
Query: 667 AGVYSCTAQNSAGSISAN-ATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRIT 725
AG Y C N G + A LTVLE PS V + V+V ++ +C+A G+P P +
Sbjct: 196 AGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVR 255
Query: 726 WFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
W K D L + + D+ L ++ V A D G YTC N +G A + L+V
Sbjct: 256 WRKDDG--ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Score = 106 bits (264), Expect = 1e-22
Identities = 85/291 (29%), Positives = 117/291 (40%), Gaps = 30/291 (10%)
Query: 494 KPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDG 553
+P + +P V F C A T W+KD+ L + E
Sbjct: 222 RPSFVKRPSNLAVTVDDSAEFKCEARGDPVP--TVRWRKDDGELPKSRYE---------- 269
Query: 554 EVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNV---LPSFTKTPHDITI 610
+ L +R+VT G G Y CV N G + A LTV V P F P D +
Sbjct: 270 --IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEA-SATLTVQVGSEPPHFVVKPRDQVV 326
Query: 611 RTTTMARLECAATGHPNPQIAWQKDGGTDF-----PAARERRMHVMPDDDVFFITDVKID 665
+C ATG+P P I W+++G + P R V D+ IT+V+
Sbjct: 327 ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITNVQRS 385
Query: 666 DAGVYSCTAQNSAGSISANATLTVLET------PSLVVPLEDRVVSVGETVALQCKATGN 719
D G Y C N AGSI A L V + P + ++ V+V T L C ATG+
Sbjct: 386 DVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGS 445
Query: 720 PPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLG 770
P P I W K +S + +N +L ++ D GRYTC S G
Sbjct: 446 PVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG 496
Score = 82.0 bits (201), Expect = 3e-15
Identities = 64/200 (32%), Positives = 94/200 (47%), Gaps = 25/200 (12%)
Query: 599 PSFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDG---GTDFPAARERRMHVMPDDD 655
P + P D+ + A L C A G P P I W K G TD R RM ++P
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGS 87
Query: 656 VFFITDV----KIDDAGVYSCTAQNSAG-SISANATLTVL-------ETPSLVVPLEDRV 703
+FF+ V D GVY C A+N G ++S NA+L V + PS D +
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS------DVM 141
Query: 704 VSVGETVALQCK-ATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYT 762
V+VGE ++C+ G+P P I+W K PL + +T L++ DAG+Y
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITIRGGKLMITYTRKSDAGKYV 200
Query: 763 CEMSNTLGTERAH-SQLSVL 781
C +N +G + ++L+VL
Sbjct: 201 CVGTNMVGERESEVAELTVL 220
Score = 54.3 bits (129), Expect = 6e-07
Identities = 50/203 (24%), Positives = 87/203 (42%), Gaps = 15/203 (7%)
Query: 495 PQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGE 554
P + +P + +G+ + F C A + + P F W+++ + + ++ +
Sbjct: 315 PHFVVKPRDQVVALGRTVTFQCEA-TGNPQPAIF-WRREG---SQNLLFSYQPPQSSSRF 369
Query: 555 VMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVL------PSFTKTPHDI 608
+ T L + V G Y C N GS + KA L V + P + P +
Sbjct: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIIT-KAYLEVTDVIADRPPPVIRQGPVNQ 428
Query: 609 TIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAG 668
T+ L C ATG P P I W+KDG + ++ R+ + ++ V I K+ D G
Sbjct: 429 TVAVDGTFVLSCVATGSPVPTILWRKDGV--LVSTQDSRIKQL-ENGVLQIRYAKLGDTG 485
Query: 669 VYSCTAQNSAGSISANATLTVLE 691
Y+C A +G + +A + V E
Sbjct: 486 RYTCIASTPSGEATWSAYIEVQE 508
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 136 bits (343), Expect = 9e-32
Identities = 96/318 (30%), Positives = 142/318 (44%), Gaps = 27/318 (8%)
Query: 492 FLKPQII---TQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHV 548
+++P I + P + GK I C P T W KD L +
Sbjct: 2287 YIRPTITNSGSHPTEIIVTRGKSISLECEV--QGIPPPTVTWMKDGHPL----------I 2334
Query: 549 HAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFT---KTP 605
A+ E+++ IL L+ + GRY CV N G T K L+V+ PS ++P
Sbjct: 2335 KAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMT-DKKYDLSVHAPPSIIGNHRSP 2393
Query: 606 HDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKID 665
+I++ L C A+G P P I W KDG +P + + ++ + + ++
Sbjct: 2394 ENISVVEKNSVSLTCEASGIPLPSITWFKDG---WPVSLSNSVRILSGGRMLRLMQTTME 2450
Query: 666 DAGVYSCTAQNSAGSISANATLTVLETPSLVVP--LEDRVVSVGETVALQCKATGNPPPR 723
DAG Y+C +N+AG L+VL P +V LED V ++V L C+ TGNP P
Sbjct: 2451 DAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPE 2510
Query: 724 ITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVLPA 783
ITW K +PL E HH+ + L + NV GRYTC S+ G + L+V +
Sbjct: 2511 ITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVS 2570
Query: 784 ---AGCRKDGTTVGIFTI 798
AG DG + I
Sbjct: 2571 PTIAGVGSDGNPEDVTVI 2588
Score = 129 bits (323), Expect = 2e-29
Identities = 86/287 (29%), Positives = 131/287 (45%), Gaps = 18/287 (6%)
Query: 495 PQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGE 554
P +I P G+ TC S+ +T+ + D +V A+
Sbjct: 520 PPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQ-RNDRDVRL-----------AEPAR 567
Query: 555 VMEYTTI-LHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTT 613
+ + L L+ V F G Y C++++ GS+ + LTV P T P + +
Sbjct: 568 IRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAA-SVFLTVQEPPKVTVMPKNQSFTGG 626
Query: 614 TMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCT 673
+ + C+ATG+P P+IAW + + R R M D FI + DAG+Y C
Sbjct: 627 SEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYR----MTSDGTLFIKNAAPKDAGIYGCL 682
Query: 674 AQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPL 733
A NSAG+ N+TL +E P L+V + +V++G+ ++CK +G PPP++ WFKGD L
Sbjct: 683 ASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLEL 742
Query: 734 SLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
+ + P LL +Q DAG YTC N G L V
Sbjct: 743 RPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDV 789
Score = 121 bits (303), Expect = 4e-27
Identities = 74/271 (27%), Positives = 131/271 (48%), Gaps = 16/271 (5%)
Query: 507 MVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILHLRQ 566
+V ++ C AA + +T W KDN +L+ + F++ G++++ +
Sbjct: 1933 LVSNPVQLECKAAGNPVPVIT--WYKDNRLLSGSTSMTFLN----RGQIID------IES 1980
Query: 567 VTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTTMARLECAATGHP 626
G Y+CV N G+T + L V+V PS + + + + + RLEC A G P
Sbjct: 1981 AQISDAGIYKCVAINSAGATELFYS-LQVHVAPSISGSNNMVAVVVNNPVRLECEARGIP 2039
Query: 627 NPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAGSISANAT 686
P + W KDG ++ + V+ + +T +I D G Y+C A N+AG +
Sbjct: 2040 APSLTWLKDGSP--VSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDID 2097
Query: 687 LTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLSLTERHHLTPDNQ 746
L V P+++ ++ V + + V L C++ PPP +TW K PL ++ +
Sbjct: 2098 LRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRS 2157
Query: 747 LLVVQNVVAEDAGRYTCEMSNTLG-TERAHS 776
+L +++ +D GRYTCE +N G TE+ ++
Sbjct: 2158 VLKIEDAQVQDTGRYTCEATNVAGKTEKNYN 2188
Score = 114 bits (285), Expect = 5e-25
Identities = 79/255 (30%), Positives = 117/255 (45%), Gaps = 8/255 (3%)
Query: 552 DGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIR 611
DG + + + + H GRY CV N GS + H L V+ P P ++ +
Sbjct: 3942 DGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRH-VTLHVHEPPVIQPQPSELHVI 4000
Query: 612 TTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYS 671
L C ATG P+P I WQK+G + R V+P + V+ +DAG Y
Sbjct: 4001 LNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHA--VLPSGGLQISRAVR-EDAGTYM 4057
Query: 672 CTAQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDR 731
C AQN AG+ L V P + L++ V++V + + L C+A G PPP ITW K R
Sbjct: 4058 CVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGR 4117
Query: 732 PLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVLPAAGCRKDGT 791
+ + R + L + V DAG YTC +N G+ ++L+V R +
Sbjct: 4118 AIVESIRQRVLSSGSLQIA-FVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIR---S 4173
Query: 792 TVGIFTIAVVSSIVL 806
T G +T+ S +L
Sbjct: 4174 TEGHYTVNENSQAIL 4188
Score = 113 bits (283), Expect = 9e-25
Identities = 76/284 (26%), Positives = 119/284 (41%), Gaps = 17/284 (5%)
Query: 502 ETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTI 561
E + + + TC A + P T AW K+++ + N+D + + ++ +
Sbjct: 3159 EVIVETISNPVTLTCDA--TGIPPPTIAWLKNHKRIENSD--------SLEVRILSGGSK 3208
Query: 562 LHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFT--KTPHDITIRTTTMARLE 619
L + + G Y C+ +N G + L++ V PS + P D+++ L
Sbjct: 3209 LQIARSQHSDSGNYTCIASNMEGKAQKYYF-LSIQVPPSVAGAEIPSDVSVLLGENVELV 3267
Query: 620 CAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAG 679
C A G P P I W KDG + R+ V + I D G Y+C A N AG
Sbjct: 3268 CNANGIPTPLIQWLKDG-KPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAG 3326
Query: 680 SISANATLTVLETPSL---VVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLSLT 736
L V TP++ E + V ++ ++C+ATG PPP+I W K PL L+
Sbjct: 3327 EEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLS 3386
Query: 737 ERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
L Q++ + D YTC SN G + H L V
Sbjct: 3387 SHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQV 3430
Score = 113 bits (282), Expect = 1e-24
Identities = 84/334 (25%), Positives = 143/334 (42%), Gaps = 25/334 (7%)
Query: 457 GRMLQAF-VTATCAHPESLKGQSIFSVPPESFVCDDFLKPQIITQ--PETTMAMVGKDIR 513
G++L+ F T A S K +I + F D + P II P ++ +D+
Sbjct: 1413 GKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVA 1472
Query: 514 FTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILHLRQVTFGHEG 573
C + + W KD + L D + E+++ +LHL+ +G
Sbjct: 1473 LECQVKGTPFPDIH--WFKDGKPLFLGD---------PNVELLDRGQVLHLKNARRNDKG 1521
Query: 574 RYQCVITNHFGSTYSHKARLTVNVLPSFT--KTPHDITIRTTTMARLECAATGHPNPQIA 631
RYQC ++N G + +LT+ + PS DI++ ++ +LEC G P P I
Sbjct: 1522 RYQCTVSNAAGKQ-AKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAIT 1580
Query: 632 WQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAGSISANATLTVLE 691
W KDG P + + I ++ D+ Y+C N AG+ + + V
Sbjct: 1581 WYKDGQ---PIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYV 1637
Query: 692 TP----SLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLSLTERHHLTPDNQL 747
P +L PL +VV + ++ L+CKA GNP P +TW K P+ + + +
Sbjct: 1638 PPMIEGNLATPLNKQVV-IAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKK 1696
Query: 748 LVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVL 781
L + + D G+Y C ++ G + ++ VL
Sbjct: 1697 LEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVL 1730
Score = 110 bits (274), Expect = 9e-24
Identities = 79/285 (27%), Positives = 124/285 (43%), Gaps = 21/285 (7%)
Query: 501 PETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTT 560
PE +V K C SS S +W+KD + L D F+ +G +++
Sbjct: 2879 PEEVTVLVNKSALIEC--LSSGSPAPRNSWQKDGQPLLEDDHHKFL----SNGRILQILN 2932
Query: 561 ILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFT-KTPHDITIRTTTMARLE 619
Q+T GRY CV N GS + L V+V PS ++T+ L
Sbjct: 2933 T----QIT--DIGRYVCVAENTAGSAKKY-FNLNVHVPPSVIGPKSENLTVVVNNFISLT 2985
Query: 620 CAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAG 679
C +G P P ++W K+ + P ++P I K+ D G Y+C A N AG
Sbjct: 2986 CEVSGFPPPDLSWLKN---EQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAG 3042
Query: 680 SISANATLTVLETPSLVVPLEDRV----VSVGETVALQCKATGNPPPRITWFKGDRPLSL 735
+LTV PS+ + + V G +V+L+C++ PPP ITW+K R ++
Sbjct: 3043 ESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITE 3102
Query: 736 TERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
+ + D Q+L ++ D G+Y C N G + + L+V
Sbjct: 3103 STHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNV 3147
Score = 108 bits (271), Expect = 2e-23
Identities = 89/303 (29%), Positives = 137/303 (45%), Gaps = 27/303 (8%)
Query: 491 DFLKPQIITQPETT---MAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVH 547
D L P I + T + MV + C + S P T W KD +++ D
Sbjct: 1728 DVLVPPAIEGGDETSYFIVMVNNLLELDCHV--TGSPPPTIMWLKDGQLIDERD------ 1779
Query: 548 VHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKT--P 605
+++ L + Q + G Y+C+ N G + + +TV+V P+ +
Sbjct: 1780 ----GFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGD-HKKEFEVTVHVPPTIKSSGLS 1834
Query: 606 HDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPA-ARERRMHVMPDDDVFFITDVKI 664
+ ++ +A L+C A G PNP I W KD D P + + + V I +
Sbjct: 1835 ERVVVKYKPVA-LQCIANGIPNPSITWLKD---DQPVNTAQGNLKIQSSGRVLQIAKTLL 1890
Query: 665 DDAGVYSCTAQNSAGSISANATLTVLETPSL--VVPLEDRVVSVGETVALQCKATGNPPP 722
+DAG Y+C A N+AG + L V E PSL + + V V V L+CKA GNP P
Sbjct: 1891 EDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVP 1950
Query: 723 RITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLG-TERAHS-QLSV 780
ITW+K +R LS + Q++ +++ DAG Y C N+ G TE +S Q+ V
Sbjct: 1951 VITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHV 2010
Query: 781 LPA 783
P+
Sbjct: 2011 APS 2013
Score = 106 bits (265), Expect = 1e-22
Identities = 79/321 (24%), Positives = 127/321 (39%), Gaps = 41/321 (12%)
Query: 486 SFVCDDFLKPQIIT-----QPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNA 540
SF + F+ P I PE ++ C A S P T W KD L +
Sbjct: 2562 SFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYP--PATITWFKDGTPLESN 2619
Query: 541 DMENFVHVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPS 600
++ ++ L + + GRY CV TN G H + V + P
Sbjct: 2620 ----------RNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHY-EVKVYIPPI 2668
Query: 601 FTK--------TPHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMP 652
K +P ++ I+ LEC A P+ ++W KDG P + +++
Sbjct: 2669 INKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQ---PLKSDDHVNIAA 2725
Query: 653 DDDVFFITDVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLVVPLE------------ 700
+ I + +I D G Y+C A N AG + + + PS E
Sbjct: 2726 NGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGE 2785
Query: 701 DRVVSVGETVALQCKATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGR 760
+ V + ++L C+ PPP +TW+K PL+ +++ + P ++L + EDAGR
Sbjct: 2786 AKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGR 2845
Query: 761 YTCEMSNTLGTERAHSQLSVL 781
YTC N G + + VL
Sbjct: 2846 YTCVAVNEAGEDSLQYDVRVL 2866
Score = 106 bits (265), Expect = 1e-22
Identities = 94/362 (25%), Positives = 151/362 (41%), Gaps = 53/362 (14%)
Query: 501 PETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTT 560
P+ V + C A + S+ ++ W KD + L + D N A +G ++
Sbjct: 2681 PKEVKIKVNNTLTLECEAYAIPSASLS--WYKDGQPLKSDDHVNI----AANGHTLQ--- 2731
Query: 561 ILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKT--------------PH 606
+++ GRY CV +N G + + V PSF K
Sbjct: 2732 ---IKEAQISDTGRYTCVASNIAGED-ELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAK 2787
Query: 607 DITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDD 666
D+ I L C P P + W KDG P ++ ++P V I K++D
Sbjct: 2788 DVIINNPIS--LYCETNAAPPPTLTWYKDG---HPLTSSDKVLILPGGRVLQIPRAKVED 2842
Query: 667 AGVYSCTAQNSAGSISANATLTVLETPSLV-----VPLEDRVVSVGETVALQCKATGNPP 721
AG Y+C A N AG S + VL P + +P E+ V V ++ ++C ++G+P
Sbjct: 2843 AGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLP-EEVTVLVNKSALIECLSSGSPA 2901
Query: 722 PRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV- 780
PR +W K +PL + H + ++L + N D GRY C NT G+ + + L+V
Sbjct: 2902 PRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVH 2961
Query: 781 LPAA--GCRKDGTTV----GIFTIAVVSSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETV 834
+P + G + + TV I VS L W+ K+E+ NT+ +
Sbjct: 2962 VPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWL--------KNEQPIKLNTNTLI 3013
Query: 835 VP 836
VP
Sbjct: 3014 VP 3015
Score = 106 bits (264), Expect = 1e-22
Identities = 81/288 (28%), Positives = 125/288 (43%), Gaps = 23/288 (7%)
Query: 501 PETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTT 560
P ++G+++ C+A + +P+ W KD + + + + E + V A + Y
Sbjct: 3253 PSDVSVLLGENVELVCNA-NGIPTPL-IQWLKDGKPIASGETER-IRVSANGSTLNIYGA 3309
Query: 561 ILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTT---TMAR 617
+ G+Y CV TN G L V V P+ + T T
Sbjct: 3310 LT-------SDTGKYTCVATNPAGEE-DRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSIN 3361
Query: 618 LECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNS 677
+EC ATG P PQI W K+G P + ++ V I ++ D VY+C A N
Sbjct: 3362 IECRATGTPPPQINWLKNG---LPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNR 3418
Query: 678 AGSISANATLTVLETPSL--VVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLSL 735
AG + + L V P++ + E+ V G + ++ C G P P + W + +PL L
Sbjct: 3419 AGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGL 3478
Query: 736 TERHHLTPDNQLLVVQNVVAE--DAGRYTCEMSNTLGTERAHSQLSVL 781
HLT +V+Q + AE D+G+YTC SN G H L VL
Sbjct: 3479 DA--HLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVL 3524
Score = 105 bits (262), Expect = 2e-22
Identities = 77/287 (26%), Positives = 132/287 (45%), Gaps = 19/287 (6%)
Query: 498 ITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVME 557
+T PE T + + CS S P T ++ ++ L D + E
Sbjct: 433 VTMPEKTPGYYLQPGQIPCSV--DSLLPFTLSFVRNGVTL------------GVDQYLKE 478
Query: 558 YTTI-LHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTTMA 616
++ L + +VT EG Y+C+ + G T + V+ P + P+++T+ A
Sbjct: 479 SASVNLDIAKVTLSDEGFYECIAVSSAG-TGRAQTFFDVSEPPPVIQVPNNVTVTPGERA 537
Query: 617 RLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQN 676
L C + + WQ++ D A R+ + + + + VK +DAG Y C +
Sbjct: 538 VLTCLIISAVDYNLTWQRND-RDVRLAEPARIRTLANLSLE-LKSVKFNDAGEYHCMVSS 595
Query: 677 SAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLSLT 736
GS +A+ LTV E P + V +++ + G V++ C ATG P P+I W D + +
Sbjct: 596 EGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGS 655
Query: 737 ERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVLPA 783
R+ +T D L + +N +DAG Y C SN+ GT++ +S L + A
Sbjct: 656 HRYRMTSDGTLFI-KNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEA 701
Score = 105 bits (262), Expect = 2e-22
Identities = 78/286 (27%), Positives = 116/286 (40%), Gaps = 14/286 (4%)
Query: 495 PQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGE 554
P I P +V C A + W+K+ +L +N + +
Sbjct: 3804 PSIAPGPTNMTVIVNVQTTLACEATGIPKPSIN--WRKNGHLLNVDQNQNSYRLLSSGSL 3861
Query: 555 VMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTT 614
V+ ++ Y+C +TN G LTV V PS P D +
Sbjct: 3862 VIISPSV--------DDTATYECTVTNGAGDD-KRTVDLTVQVPPSIADEPTDFLVTKHA 3912
Query: 615 MARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTA 674
A + C A+G P P I W K+G P R+ I +++ AG Y+C A
Sbjct: 3913 PAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRIL---SSGAIEILATQLNHAGRYTCVA 3969
Query: 675 QNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLS 734
+N+AGS + TL V E P + + V + + L C+ATG P P ITW K ++
Sbjct: 3970 RNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVN 4029
Query: 735 LTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
+ R+H + L + V EDAG Y C N GT +L+V
Sbjct: 4030 TSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNV 4075
Score = 105 bits (262), Expect = 2e-22
Identities = 74/277 (26%), Positives = 117/277 (42%), Gaps = 17/277 (6%)
Query: 498 ITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVME 557
+ P ++ D T S + P W KD + + + + +
Sbjct: 4080 VISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGS------- 4132
Query: 558 YTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTTMAR 617
L + V G G Y C+ N GS+ S +LTV+V P T T+ + A
Sbjct: 4133 ----LQIAFVQPGDAGHYTCMAANVAGSS-STSTKLTVHVPPRIRSTEGHYTVNENSQAI 4187
Query: 618 LECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNS 677
L C A G P P I W+KD + A + + +V ++D+G Y+C A N+
Sbjct: 4188 LPCVADGIPTPAINWKKD---NVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNA 4244
Query: 678 AGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLSLTE 737
AG + +LTV P+ D ++ GE + L CKATG P P++TW + +
Sbjct: 4245 AGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNN--IIPA 4302
Query: 738 RHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERA 774
+ LV++ V ED+G Y C N++G +A
Sbjct: 4303 HFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKA 4339
Score = 104 bits (259), Expect = 5e-22
Identities = 79/281 (28%), Positives = 119/281 (42%), Gaps = 18/281 (6%)
Query: 502 ETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTI 561
E +V + TC A+ + MT W KD L D + GEV+ +T
Sbjct: 3536 EEISVIVNNPLELTCIASGIPAPKMT--WMKDGRPLPQTDQVQTLG----GGEVLRISTA 3589
Query: 562 LHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKT--PHDITIRTTTMARLE 619
QV GRY C+ ++ G + + V+V P+ T P DIT+ LE
Sbjct: 3590 ----QVE--DTGRYTCLASSPAGDD-DKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLE 3642
Query: 620 CAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAG 679
C + P P I W ++G R+ ++ I + + D Y+C A N AG
Sbjct: 3643 CKSDAVPPPVITWLRNGER---LQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAG 3699
Query: 680 SISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLSLTERH 739
+ LTV P++ + V+ + ++ L+C A G P PRITW K L+
Sbjct: 3700 KTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHAR 3759
Query: 740 HLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
+ +N L +Q+ D GRY C +N GT+R L V
Sbjct: 3760 YSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQV 3800
Score = 104 bits (259), Expect = 5e-22
Identities = 77/249 (30%), Positives = 108/249 (43%), Gaps = 19/249 (7%)
Query: 530 WKKDNEVLTNADMENFVHVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSH 589
WKKDN +L N + + + L L V G Y CV N G +H
Sbjct: 4202 WKKDNVLLANLLGKYTAEPYGE----------LILENVVLEDSGFYTCVANNAAGED-TH 4250
Query: 590 KARLTVNVLPSFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMH 649
LTV+VLP+FT+ P D+++ RL C ATG P P++ W + PA
Sbjct: 4251 TVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNI-IPA----HFD 4305
Query: 650 VMPDDDVFFITDVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLVVPLEDRVVS-VGE 708
+ I V +D+G Y CTA+NS G + A + V E P + +G
Sbjct: 4306 SVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGG 4365
Query: 709 TVALQCKATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNT 768
L C+ G+P P I W + + ++ R N L + V EDAG YTC +N
Sbjct: 4366 NAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQL-GNGSLAIYGTVNEDAGDYTCVATNE 4424
Query: 769 LG-TERAHS 776
G ER+ S
Sbjct: 4425 AGVVERSMS 4433
Score = 102 bits (254), Expect = 2e-21
Identities = 74/296 (25%), Positives = 125/296 (42%), Gaps = 23/296 (7%)
Query: 492 FLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQ 551
++ P I+ + + ++ + + C S + P T W KD L +
Sbjct: 2101 YVPPNIMGEEQNVSVLISQAVELLCQ--SDAIPPPTLTWLKDGHPL----------LKKP 2148
Query: 552 DGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGST---YSHKARLTVNVLPSFTKTPHDI 608
+ E ++L + GRY C TN G T Y+ + N+ S T +
Sbjct: 2149 GLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELT--QL 2206
Query: 609 TIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAG 668
T+ + L C ++G P P + W+K G + R + ++ I+ + DA
Sbjct: 2207 TVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGR-VRILSGGRQLQISIAEKSDAA 2265
Query: 669 VYSCTAQNSAGSISANATLTVLETPSLV----VPLEDRVVSVGETVALQCKATGNPPPRI 724
+YSC A N AG+ L V P++ P E +V+ G++++L+C+ G PPP +
Sbjct: 2266 LYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTE-IIVTRGKSISLECEVQGIPPPTV 2324
Query: 725 TWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
TW K PL + + + +L ++N+ D GRY C N G LSV
Sbjct: 2325 TWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSV 2380
Score = 99.4 bits (246), Expect = 2e-20
Identities = 73/277 (26%), Positives = 117/277 (42%), Gaps = 20/277 (7%)
Query: 500 QPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYT 559
+ E M +V I C A + + P W K+ L + H+ ++
Sbjct: 3348 EAEKLMTLVDTSINIECRA--TGTPPPQINWLKNGLPLPLSS-----HIR-----LLAAG 3395
Query: 560 TILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKT--PHDITIRTTTMAR 617
++ + + Y CV +N G H L V P+ + +IT+ +
Sbjct: 3396 QVIRIVRAQVSDVAVYTCVASNRAGVDNKHY-NLQVFAPPNMDNSMGTEEITVLKGSSTS 3454
Query: 618 LECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNS 677
+ C G P P +AW +DG P + + V V + + +D+G Y+C A N
Sbjct: 3455 MACITDGTPAPSMAWLRDGQ---PLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNE 3511
Query: 678 AGSISANATLTVLETPSLVVPLEDRVVS--VGETVALQCKATGNPPPRITWFKGDRPLSL 735
AG +S + L VLE P + E +S V + L C A+G P P++TW K RPL
Sbjct: 3512 AGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQ 3571
Query: 736 TERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTE 772
T++ ++L + ED GRYTC S+ G +
Sbjct: 3572 TDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDD 3608
Score = 98.2 bits (243), Expect = 4e-20
Identities = 75/289 (25%), Positives = 114/289 (39%), Gaps = 18/289 (6%)
Query: 495 PQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGE 554
P I E V ++ + T S + P W ++ E L
Sbjct: 3620 PNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVR---------- 3669
Query: 555 VMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTT 614
++ L + G Y CV +N G T + + LTVNV P+ P + I
Sbjct: 3670 ILSGGRYLQINNADLGDTANYTCVASNIAGKT-TREFILTVNVPPNIKGGPQSLVILLNK 3728
Query: 615 MARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTA 674
LEC A G P P+I W+KDG A + + ++ I + D G Y C A
Sbjct: 3729 STVLECIAEGVPTPRITWRKDGAV---LAGNHARYSILENGFLHIQSAHVTDTGRYLCMA 3785
Query: 675 QNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLS 734
N+AG+ L V PS+ + V V L C+ATG P P I W K L+
Sbjct: 3786 TNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLN 3845
Query: 735 LTER---HHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
+ + + L L+++ V +D Y C ++N G ++ L+V
Sbjct: 3846 VDQNQNSYRLLSSGSLVIISPSV-DDTATYECTVTNGAGDDKRTVDLTV 3893
Score = 97.8 bits (242), Expect = 5e-20
Identities = 84/287 (29%), Positives = 117/287 (40%), Gaps = 19/287 (6%)
Query: 495 PQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGE 554
P I QP ++ I C A + S +T W+K+ N + H G
Sbjct: 3988 PVIQPQPSELHVILNNPILLPCEATGTPSPFIT--WQKEG---INVNTSGRNHAVLPSGG 4042
Query: 555 VMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTT 614
L + + G Y CV N G+ K +L V V P + + I
Sbjct: 4043 -------LQISRAVREDAGTYMCVAQNPAGTALG-KIKLNVQVPPVISPHLKEYVIAVDK 4094
Query: 615 MARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTA 674
L C A G P P I W KDG + R+R + I V+ DAG Y+C A
Sbjct: 4095 PITLSCEADGLPPPDITWHKDGRAIVESIRQRVL----SSGSLQIAFVQPGDAGHYTCMA 4150
Query: 675 QNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLS 734
N AGS S + LTV P + V+ L C A G P P I W K + L+
Sbjct: 4151 ANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLA 4210
Query: 735 -LTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
L ++ P +L +++NVV ED+G YTC +N G + L+V
Sbjct: 4211 NLLGKYTAEPYGEL-ILENVVLEDSGFYTCVANNAAGEDTHTVSLTV 4256
Score = 95.1 bits (235), Expect = 3e-19
Identities = 74/283 (26%), Positives = 110/283 (38%), Gaps = 34/283 (12%)
Query: 512 IRFTCSAASSSSSPMTFAWKKDNEVLT------NADMENFVHVHAQDGEVMEYTTILHLR 565
I T +S + + W K E+++ +A + ++V + GE
Sbjct: 996 IPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGE----------- 1044
Query: 566 QVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSF--------TKTPHDITIRTTTMAR 617
G Y C TN G K +LTV V P P +I++
Sbjct: 1045 -----ESGEYVCTATNTAGYA-KRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVT 1098
Query: 618 LECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNS 677
L C P P I W K+ P + H IT+ + D+G+Y C A N
Sbjct: 1099 LPCEVKSLPPPIITWAKETQLISPFSPR---HTFLPSGSMKITETRTSDSGMYLCVATNI 1155
Query: 678 AGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLSLTE 737
AG+++ L V P + + V VG+ V + C A G P P ITW KG + +
Sbjct: 1156 AGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDG 1215
Query: 738 RHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
HH++ + L + DAG YTC +N GT+ L V
Sbjct: 1216 EHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHV 1258
Score = 94.7 bits (234), Expect = 4e-19
Identities = 73/291 (25%), Positives = 116/291 (39%), Gaps = 21/291 (7%)
Query: 495 PQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGE 554
P I +V +R C A + +T W KD +++ + +
Sbjct: 2012 PSISGSNNMVAVVVNNPVRLECEARGIPAPSLT--WLKDGSPVSS---------FSNGLQ 2060
Query: 555 VMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTT 614
V+ IL L GRY CV N G L V V P+ ++++ +
Sbjct: 2061 VLSGGRILALTSAQISDTGRYTCVAVNAAGEK-QRDIDLRVYVPPNIMGEEQNVSVLISQ 2119
Query: 615 MARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTA 674
L C + P P + W KDG P ++ + + + V I D ++ D G Y+C A
Sbjct: 2120 AVELLCQSDAIPPPTLTWLKDG---HPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEA 2176
Query: 675 QNSAGSISANATLTVLETPSL--VVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRP 732
N AG N + + P++ L V G ++L C+++G PPP + W K P
Sbjct: 2177 TNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSP 2236
Query: 733 LSLTE---RHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
+ LT+ R + + L + DA Y+C SN GT + L V
Sbjct: 2237 V-LTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQV 2286
Score = 92.8 bits (229), Expect = 2e-18
Identities = 65/217 (29%), Positives = 92/217 (42%), Gaps = 15/217 (6%)
Query: 573 GRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHD------ITIRTTTMARLECAATGHP 626
G Y C+ N G + K LTV V PS HD + +R T LEC + P
Sbjct: 3031 GEYTCIAINQAGES-KKKFSLTVYVPPSIKD--HDSESLSVVNVREGTSVSLECESNAVP 3087
Query: 627 NPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAGSISANAT 686
P I W K+G + ++ D + I ++ D G Y C A N AG N
Sbjct: 3088 PPVITWYKNGRM---ITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFH 3144
Query: 687 LTVLETPSLVVPLEDRVV-SVGETVALQCKATGNPPPRITWFKGDRPLSLTE--RHHLTP 743
L V PS+ P + +V ++ V L C ATG PPP I W K + + ++ +
Sbjct: 3145 LNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILS 3204
Query: 744 DNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
L + D+G YTC SN G + + LS+
Sbjct: 3205 GGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSI 3241
Score = 89.7 bits (221), Expect = 1e-17
Identities = 80/298 (26%), Positives = 124/298 (41%), Gaps = 30/298 (10%)
Query: 495 PQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGE 554
P+I P+ VG+ + C+A + +T W K + D E+ HV DG
Sbjct: 1171 PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVIT--WSKGGSTML-VDGEH--HVSNPDGT 1225
Query: 555 VMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTT 614
L + Q T G Y CV TN G+ + +T++V T + TT
Sbjct: 1226 -------LSIDQATPSDAGIYTCVATNIAGTD---ETEITLHVQEPPTVEDLEPPYNTTF 1275
Query: 615 MARLE-------CAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDA 667
R+ C A G P P I W +G RE + ++ D + I V D
Sbjct: 1276 QERVANQRIEFPCPAKGTPKPTIKWLHNGRE--LTGREPGISILEDGTLLVIASVTPYDN 1333
Query: 668 GVYSCTAQNSAGSISANATLTVLETPSLVVPLEDRVVSVG----ETVALQCKATGNPPPR 723
G Y C A N AG+ L V P V+ +++V +V + L C+ G P P
Sbjct: 1334 GEYICVAVNEAGTTERKYNLKVHVPP--VIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPI 1391
Query: 724 ITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVL 781
I W+K + ++ + + ++L + EDAGRY+C+ N GT + + + VL
Sbjct: 1392 IMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVL 1449
Score = 79.7 bits (195), Expect = 1e-14
Identities = 69/292 (23%), Positives = 111/292 (38%), Gaps = 25/292 (8%)
Query: 495 PQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGE 554
P++ P+ G ++ CSA + AW ++ + + DG
Sbjct: 612 PKVTVMPKNQSFTGGSEVSIMCSATGYPKPKI--AWTVNDMFIVGSHRYRMT----SDGT 665
Query: 555 VMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTT 614
L ++ G Y C+ +N G T + L P ++ +
Sbjct: 666 -------LFIKNAAPKDAGIYGCLASNSAG-TDKQNSTLRYIEAPKLMVVQSELLVALGD 717
Query: 615 MARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTA 674
+ +EC +G P PQ+ W K D + + P + I + + DAG Y+C A
Sbjct: 718 ITVMECKTSGIPPPQVKWFKG---DLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVA 774
Query: 675 QNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGD---- 730
N AG + TL V P + D + +G V L C G P P I W + D
Sbjct: 775 INEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPI 834
Query: 731 --RPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
RP S++ L L + N+ A D G Y CE N G ++ + ++V
Sbjct: 835 FSRPFSVSSISQLR--TGALFILNLWASDKGTYICEAENQFGKIQSETTVTV 884
Score = 79.7 bits (195), Expect = 1e-14
Identities = 65/264 (24%), Positives = 110/264 (41%), Gaps = 21/264 (7%)
Query: 509 GKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILHLRQVT 568
G+ +R +C A +T W +N ++ H + +G + L + +V+
Sbjct: 4274 GEQLRLSCKATGIPLPKLT--WTFNNNIIP-------AHFDSVNGH-----SELVIERVS 4319
Query: 569 FGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKT-PHDITIRTTTMARLECAATGHPN 627
G Y C N G + + V P F P + A L C G P
Sbjct: 4320 KEDSGTYVCTAENSVGFVKAI-GFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPT 4378
Query: 628 PQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAGSISANATL 687
P I W + G + R R++ + I +DAG Y+C A N AG + + +L
Sbjct: 4379 PTIQWNRKGVDIEISHRIRQL----GNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSL 4434
Query: 688 TVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLSLTERHHLTPDNQL 747
T+ P + + + V++ G + L C+ATG P P ITW + +S +R ++ +N L
Sbjct: 4435 TLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNSL 4494
Query: 748 LVVQNVVAEDAGRYTCEMSNTLGT 771
+ + ED + C N +G+
Sbjct: 4495 YIA-DAQKEDTSEFECVARNLMGS 4517
Score = 78.6 bits (192), Expect = 3e-14
Identities = 63/279 (22%), Positives = 106/279 (37%), Gaps = 21/279 (7%)
Query: 507 MVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILHLRQ 566
++ I+ C +T W KD + + ++ ++ + LH+ +
Sbjct: 1560 LINSLIKLECETRGLPMPAIT--WYKDGQPIMSSSQALYI----------DKGQYLHIPR 1607
Query: 567 VTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFT---KTPHDITIRTTTMARLECAAT 623
Y C + N G T + V V P TP + + LEC A
Sbjct: 1608 AQVSDSATYTCHVANVAG-TAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAA 1666
Query: 624 GHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAGSISA 683
G+P+P + W KDG P + + I + D G Y C A + AG
Sbjct: 1667 GNPSPILTWLKDG---VPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEI 1723
Query: 684 NATLTVLETPSLVVPLEDR--VVSVGETVALQCKATGNPPPRITWFKGDRPLSLTERHHL 741
+ VL P++ E +V V + L C TG+PPP I W K + + + +
Sbjct: 1724 KYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKI 1783
Query: 742 TPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
+ + LV+ + G Y C +NT G + +++V
Sbjct: 1784 LLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTV 1822
Score = 76.3 bits (186), Expect = 2e-13
Identities = 69/289 (23%), Positives = 108/289 (37%), Gaps = 16/289 (5%)
Query: 495 PQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKK-DNEVLTNADMENFVHVHAQDG 553
P I +P +G ++ C T W++ DN M F +
Sbjct: 793 PVFIQEPADVSMEIGSNVTLPCYVQGYPEP--TIKWRRLDN-------MPIFSRPFSVSS 843
Query: 554 EVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKA-RLTVNVLPSFTKTPHDITIRT 612
T L + + +G Y C N FG S +T V P +P +
Sbjct: 844 ISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIE 903
Query: 613 TTMARLECAA-TGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYS 671
L C G+P P+ W K+ + + D I V++ D G Y+
Sbjct: 904 GQQLTLPCTLLAGNPIPERRWIKNSAM----LLQNPYITVRSDGSLHIERVQLQDGGEYT 959
Query: 672 CTAQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDR 731
C A N AG+ + ++ V P++ + G V L CKA+GNP P + W K
Sbjct: 960 CVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGE 1019
Query: 732 PLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780
+S + + L V + E++G Y C +NT G + QL+V
Sbjct: 1020 LISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTV 1068
Score = 55.8 bits (133), Expect = 2e-07
Identities = 34/117 (29%), Positives = 53/117 (45%), Gaps = 5/117 (4%)
Query: 573 GRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTTMARLECAATGHPNPQIAW 632
G Y CV TN G LT+ P T P + I L C ATG P P I W
Sbjct: 4415 GDYTCVATNEAG-VVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITW 4473
Query: 633 QKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAGSISANATLTV 689
+ G + + + R++V+ ++ ++ I D + +D + C A+N GS+ + V
Sbjct: 4474 SRQGHS---ISWDDRVNVLSNNSLY-IADAQKEDTSEFECVARNLMGSVLVRVPVIV 4526
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 136 bits (343), Expect = 9e-32
Identities = 113/346 (32%), Positives = 164/346 (47%), Gaps = 16/346 (4%)
Query: 142 EVLDLSL--NNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNR 199
+VL SL N IT + F ++ L+L N+I +L F+ LSR L L L N
Sbjct: 60 DVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSR-LEELYLGNNL 118
Query: 200 ITQL-PVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGL 258
+ L P L +L L N N I + +F+GL SL L+L N + L D F L
Sbjct: 119 LQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPL 178
Query: 259 SKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFC--QKLHELVLSF 316
+ LHLE N + + + L L L+LS N + R +F + L L+LS
Sbjct: 179 GNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSA 238
Query: 317 NNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSG 376
NNL L L L +L L N ++H+A AF GL +LR L L+ N +S + +
Sbjct: 239 NNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLS---QLPTA 295
Query: 377 AFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELH 436
L SL L L GN++ ++ F L L L+L NA+ ++ D F L L
Sbjct: 296 LLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLD 355
Query: 437 ISSDSFLCDCQLKWLPPWL-----IGRMLQAFVTATCAHPESLKGQ 477
+ + + CDC+L+ L W+ GR+L FV C HP +L+G+
Sbjct: 356 LDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFV--QCRHPPALRGK 399
Score = 102 bits (254), Expect = 2e-21
Identities = 90/298 (30%), Positives = 131/298 (43%), Gaps = 27/298 (9%)
Query: 71 RSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSV 130
R L+L YN++ + P FE L L+E+YL NN L A+
Sbjct: 86 RRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAP--------------------- 124
Query: 131 EGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSL 190
L L +L + N I+ + F + +L L GN +G L F L +L
Sbjct: 125 --GTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLG-NL 181
Query: 191 LTLRLSKNRITQLPVRAF-KLPRLTQLDLNRNRIR--LIEGLTFQGLNSLEVLKLQRNNI 247
L L L NRI L AF +L +L L+L+ N ++ L TF L SL L L NN+
Sbjct: 182 LYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNL 241
Query: 248 SKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQ 307
L F L ++ +L L N L + + +GL AL +L L N ++++
Sbjct: 242 QHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLH 301
Query: 308 KLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHN 365
L L LS N L+ L + L L L L +N++S ++ F +L LDLD N
Sbjct: 302 SLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGN 359
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 136 bits (342), Expect = 1e-31
Identities = 132/457 (28%), Positives = 211/457 (46%), Gaps = 40/457 (8%)
Query: 143 VLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQ 202
+LDL N I + F P ++EL L N + +E GAF+ L +L TL L NR+
Sbjct: 75 LLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLF-NLRTLGLRSNRLKL 133
Query: 203 LPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKM 261
+P+ F L LT+LD++ N+I ++ FQ L +L+ L++ N++ ++ AF GL+ +
Sbjct: 134 IPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSL 193
Query: 262 HVLHLEYNSLVEVNSGSL---YGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNN 318
L LE +L + + +L +GL L HL+ N+I + +SF + VL ++
Sbjct: 194 EQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAI-----RDYSFKRLYRLKVLEISH 248
Query: 319 LTRLDEESLAELSSLSVLRLS--HNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSG 376
LD + L L++ LS H +++ + A + L LR L+L +N IS TIE +
Sbjct: 249 WPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS-TIEGSM- 306
Query: 377 AFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELH 436
L L ++ L G ++ V AF GL L LN+ GN + +++ F + NL+ L
Sbjct: 307 -LHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLI 365
Query: 437 ISSDSFLCDCQLKWL--PPWLIGRMLQAFVTATCAHPESLKGQSIFSVP----PESFVCD 490
+ S+ CDC+L W+ W + Q TCA PE ++G+ P P F C
Sbjct: 366 LDSNPLACDCRLLWVFRRRWRLNFNRQ---QPTCATPEFVQGKEFKDFPDVLLPNYFTC- 421
Query: 491 DFLKPQIITQPETTMAMV--GKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHV 548
+ I + V G ++F C A P W + L +A + V
Sbjct: 422 ---RRARIRDRKAQQVFVDEGHTVQFVCRA--DGDPPPAILWLSPRKHLVSAKSNGRLTV 476
Query: 549 HAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGS 585
DG L +R G Y C+ N G+
Sbjct: 477 F-PDG-------TLEVRYAQVQDNGTYLCIAANAGGN 505
Score = 40.4 bits (93), Expect = 0.009
Identities = 28/80 (35%), Positives = 36/80 (45%), Gaps = 4/80 (5%)
Query: 704 VSVGETVALQCKATGNPPPRITWFKGDRPL-SLTERHHLT--PDNQLLVVQNVVAEDAGR 760
V G TV C+A G+PPP I W + L S LT PD L V+ +D G
Sbjct: 436 VDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG-TLEVRYAQVQDNGT 494
Query: 761 YTCEMSNTLGTERAHSQLSV 780
Y C +N G + + L V
Sbjct: 495 YLCIAANAGGNDSMPAHLHV 514
Score = 35.8 bits (81), Expect = 0.23
Identities = 23/70 (32%), Positives = 30/70 (42%), Gaps = 1/70 (1%)
Query: 620 CAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAG 679
C A G P P I W A R+ V PD + + ++ D G Y C A N+ G
Sbjct: 446 CRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDGTLE-VRYAQVQDNGTYLCIAANAGG 504
Query: 680 SISANATLTV 689
+ S A L V
Sbjct: 505 NDSMPAHLHV 514
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 134 bits (337), Expect = 5e-31
Identities = 130/469 (27%), Positives = 228/469 (48%), Gaps = 37/469 (7%)
Query: 139 LSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKN 198
+ ++LDLS N + V F P ++E++L+ N I +E GAF+ L +L +LRL N
Sbjct: 57 IETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLF-NLRSLRLKGN 115
Query: 199 RITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWG 257
R+ +P+ F L LT+LD++ N+I ++ FQ L++L+ L++ N++ ++ AF G
Sbjct: 116 RLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSG 175
Query: 258 LSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFN 317
L + L LE +L V + +L L +L LHL + +I + ++F + H L +
Sbjct: 176 LLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNM--PVYAFKRLFHLKHLEID 233
Query: 318 NLTRLDEESLAELSSLSVLRLS--HNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTS 375
LD L L++ LS + ++S + AFK L L L+L +N IS TIE +
Sbjct: 234 YWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPIS-TIE--A 290
Query: 376 GAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKEL 435
G FS L L +L + G +++++ +F GL L LN+ N + +++ + F + L+ L
Sbjct: 291 GMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVL 350
Query: 436 HISSDSFLCDCQLKWL----PPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPES----F 487
I+++ CDC+L W+ P G CA P++++ +S + F
Sbjct: 351 SINNNPLACDCRLLWILQRQPTLQFGGQ-----QPMCAGPDTIRERSFKDFHSTALSFYF 405
Query: 488 VCDDFLKPQIITQP-ETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFV 546
C KP+I + + + G+ ++ CSA +++ + + T ++ V
Sbjct: 406 TCK---KPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATV 462
Query: 547 HVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTV 595
DG L +R G Y C+ +N G+ + A LTV
Sbjct: 463 ---LGDG-------TLEIRFAQDQDSGMYVCIASNAAGND-TFTASLTV 500
Score = 110 bits (275), Expect = 7e-24
Identities = 114/430 (26%), Positives = 192/430 (44%), Gaps = 34/430 (7%)
Query: 22 WLLLLRLEPVTAAAGPRAPCAAACTCAGD--SLDCGGRGLAALPGDLPSWTRSLNLSYNK 79
W L L V G C A C C+ S+ C R L A+P +P T+ L+LS N+
Sbjct: 9 WQPFLGLAVVLIFMGSTIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNR 68
Query: 80 LSEIDPAGFEDLPNLQEVYLNNNELTAV-PSLGAASSHVVSLFLQHNKIRSVEGSQLKAY 138
L ++P F P L+E+ L++N + V P ++ SL L+ N+++ V
Sbjct: 69 LKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGL 128
Query: 139 LSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKN 198
+L LD+S N I + + F +K L + N + + AF GL SL L L K
Sbjct: 129 SNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGL-LSLEQLTLEKC 187
Query: 199 RITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGL 258
+T +P A L SL L L+ NI+ + AF L
Sbjct: 188 NLTAVPTEA-----------------------LSHLRSLISLHLKHLNINNMPVYAFKRL 224
Query: 259 SKMHVLHLEYNSLVE-VNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFN 317
+ L ++Y L++ + + SLYGL L L ++N +++ + + L L LS+N
Sbjct: 225 FHLKHLEIDYWPLLDMMPANSLYGLN-LTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYN 283
Query: 318 NLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGA 377
++ ++ ++L L L + + I +F+GLR LRVL++ N + T+E+
Sbjct: 284 PISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLE-TLEE--NV 340
Query: 378 FSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHI 437
FS +L L++ N + + + L+ L GG D ++ ++ K+ H
Sbjct: 341 FSSPRALEVLSINNNPLACDCRLLWI-LQRQPTLQFGGQQPMCAGPDT-IRERSFKDFHS 398
Query: 438 SSDSFLCDCQ 447
++ SF C+
Sbjct: 399 TALSFYFTCK 408
Score = 42.7 bits (99), Expect = 0.002
Identities = 25/84 (29%), Positives = 41/84 (48%), Gaps = 2/84 (2%)
Query: 699 LEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLSLTERHHLTP--DNQLLVVQNVVAE 756
L+ +V G+TV L+C A G+P P I+W R T+ + + L ++ +
Sbjct: 417 LQHLLVDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQDQ 476
Query: 757 DAGRYTCEMSNTLGTERAHSQLSV 780
D+G Y C SN G + + L+V
Sbjct: 477 DSGMYVCIASNAAGNDTFTASLTV 500
Score = 42.4 bits (98), Expect = 0.002
Identities = 26/75 (34%), Positives = 38/75 (50%), Gaps = 5/75 (6%)
Query: 617 RLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDD--DVFFITDVKIDDAGVYSCTA 674
+LEC+A G P P I+W R V+ D ++ F D D+G+Y C A
Sbjct: 429 QLECSADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQD---QDSGMYVCIA 485
Query: 675 QNSAGSISANATLTV 689
N+AG+ + A+LTV
Sbjct: 486 SNAAGNDTFTASLTV 500
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,401,463
Number of Sequences: 37866
Number of extensions: 2238322
Number of successful extensions: 17031
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 461
Number of HSP's successfully gapped in prelim test: 306
Number of HSP's that attempted gapping in prelim test: 7126
Number of HSP's gapped (non-prelim): 4114
length of query: 1093
length of database: 18,247,518
effective HSP length: 113
effective length of query: 980
effective length of database: 13,968,660
effective search space: 13689286800
effective search space used: 13689286800
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.