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Search of human proteins with 5453894
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo
sapiens]
(1070 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo sa... 2167 0.0
gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo... 1184 0.0
gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypept... 737 0.0
gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypept... 503 e-142
gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptid... 360 4e-99
gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide... 348 2e-95
gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptid... 282 1e-75
gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapi... 171 3e-42
gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1 ... 115 3e-25
gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform ... 115 3e-25
gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo sa... 104 5e-22
gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase... 74 6e-13
gi|13654237 protein kinase, DNA-activated, catalytic polypeptide... 65 4e-10
gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens] 59 3e-08
gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens] 59 3e-08
gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, pa... 59 3e-08
gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens] 58 4e-08
gi|4826730 FK506 binding protein 12-rapamycin associated protein... 56 2e-07
gi|126032350 protein kinase, DNA-activated, catalytic polypeptid... 56 2e-07
gi|113430845 PREDICTED: similar to protein kinase, DNA-activated... 56 2e-07
gi|157266317 ataxia telangiectasia and Rad3 related protein [Hom... 49 2e-05
gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad... 49 2e-05
gi|110611228 utrophin [Homo sapiens] 33 1.1
gi|4502015 A-kinase anchor protein 1 precursor [Homo sapiens] 33 1.4
gi|153792694 baculoviral IAP repeat-containing 6 [Homo sapiens] 33 1.9
gi|5453976 protein kinase C, theta [Homo sapiens] 32 3.2
gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens] 32 4.2
gi|148277111 oncomodulin-like [Homo sapiens] 30 9.3
gi|147906122 oncomodulin [Homo sapiens] 30 9.3
gi|158534055 round spermatid basic protein 1-like [Homo sapiens] 30 9.3
>gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo
sapiens]
Length = 1070
Score = 2167 bits (5615), Expect = 0.0
Identities = 1070/1070 (100%), Positives = 1070/1070 (100%)
Query: 1 MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLW 60
MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLW
Sbjct: 1 MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLW 60
Query: 61 KQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE 120
KQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
Sbjct: 61 KQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE 120
Query: 121 KLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEH 180
KLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEH
Sbjct: 121 KLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEH 180
Query: 181 EPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDE 240
EPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDE
Sbjct: 181 EPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDE 240
Query: 241 VSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAI 300
VSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAI
Sbjct: 241 VSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAI 300
Query: 301 EAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG 360
EAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
Sbjct: 301 EAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG 360
Query: 361 TELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTI 420
TELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTI
Sbjct: 361 TELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTI 420
Query: 421 NPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQ 480
NPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQ
Sbjct: 421 NPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQ 480
Query: 481 TNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKE 540
TNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKE
Sbjct: 481 TNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKE 540
Query: 541 ILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK 600
ILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
Sbjct: 541 ILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK 600
Query: 601 LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL 660
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
Sbjct: 601 LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL 660
Query: 661 LERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK 720
LERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
Sbjct: 661 LERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK 720
Query: 721 TLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMD 780
TLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMD
Sbjct: 721 TLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMD 780
Query: 781 SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG 840
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
Sbjct: 781 SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG 840
Query: 841 CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE 900
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
Sbjct: 841 CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE 900
Query: 901 FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL 960
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
Sbjct: 901 FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL 960
Query: 961 TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD 1020
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
Sbjct: 961 TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD 1020
Query: 1021 IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS 1070
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
Sbjct: 1021 IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS 1070
>gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo
sapiens]
Length = 1044
Score = 1184 bits (3064), Expect = 0.0
Identities = 607/1069 (56%), Positives = 780/1069 (72%), Gaps = 32/1069 (2%)
Query: 7 MPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNY 66
MPP + ++ W + + S+ VDFLLPTG+Y+ V R A +S IKQ+LW +
Sbjct: 1 MPPGVDCPMEFWTKEE----NQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYE 56
Query: 67 PMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGEKL-DSK 125
P+F++L ++Y+F C+NQTA +ELEDE RRLCDV+PFLPVL+LV R D +KL +S+
Sbjct: 57 PLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQ 116
Query: 126 IGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEHEPSI- 184
I +LIGKGLHEFDSL DPEVN+FR KM +F EE L W WL+ ++P + EPS
Sbjct: 117 ISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQ 176
Query: 185 ---PENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDEV 241
P L +L L+V V FE ++ F+FQVS P+ + A++K+ T+ +
Sbjct: 177 TWGPGTL--RLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVE 234
Query: 242 SPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAIE 301
P DY LQV+GR EY++G +PL QFQYI +C+ + PH +V I M +++ +
Sbjct: 235 QPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQ--SNP 292
Query: 302 AAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHGT 361
A + P P+P KK +S +W PF+I L++G+K+N +E +K+ V+AGLFHG
Sbjct: 293 APQVQKPRAKPPPIPAKKPSSVS-LWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGN 351
Query: 362 ELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTIN 421
E+LCKT+ SSEVS ++ +W + LEFDINICDLPRMARLCFA+YAV++K K +STK
Sbjct: 352 EMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTK--- 408
Query: 422 PSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQT 481
+K+ K P+AW N M+FD+K QL+TG+ L+ W S PDE E+LNP GTV++
Sbjct: 409 -------KKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRS 461
Query: 482 NPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKEI 541
NP T++A AL + PE P YYP +KI+E S+ +V+ + L+EI
Sbjct: 462 NPNTDSAAALLICLPEVAPHPVYYPALEKILELGRH---SECVHVTEEEQLQ----LREI 514
Query: 542 LDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKL 601
L+R +L E+E DL+W LR + +E FP++L +LLL KWNK EDVAQ+ LL WP+L
Sbjct: 515 LERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPEL 574
Query: 602 PPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLL 661
P ALELLDF++PD +V +A+ LR+++D+EL QYLLQLVQVLKYE +LDC L++FLL
Sbjct: 575 PVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLL 634
Query: 662 ERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLKT 721
+RAL NR+IG FLFWHLRSE+H+P+V+++FG+ILEAYCRGS HMKVL KQ EAL+KLK
Sbjct: 635 DRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKA 694
Query: 722 LNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMDS 781
LN +KL++ K + + KE MH C++Q AY EALS LQSPL+P +L+E+ VE+C +MDS
Sbjct: 695 LNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDS 754
Query: 782 KMKPLWLVYNNKVFGED-SVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG 840
KMKPLW++Y+N+ G SVG+IFKNGDDLRQDMLTLQM++LMD+LWK+ GLDLRM PYG
Sbjct: 755 KMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYG 814
Query: 841 CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE 900
CL TGDR+GLIEVV S+TIA+IQLN SN+AA AAFNKDALLNWLK N G+ LDRAIEE
Sbjct: 815 CLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEE 874
Query: 901 FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL 960
FTLSCAGYCVA+YVLGIGDRHSDNIM++++GQLFHIDFGH LGNFK+KFGI RERVPFIL
Sbjct: 875 FTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFIL 934
Query: 961 TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD 1020
TYDF+HVIQQGKT N+EKF RFR CE AY ILRRHG LF+ LFALM AGLPEL+ KD
Sbjct: 935 TYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKD 994
Query: 1021 IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYR 1069
IQYLKDSLALGK+EEEALK F+ KF+EALRESW TKVNW+AH V KD R
Sbjct: 995 IQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNR 1043
>gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypeptide
[Homo sapiens]
Length = 1068
Score = 737 bits (1902), Expect = 0.0
Identities = 439/1073 (40%), Positives = 629/1073 (58%), Gaps = 64/1073 (5%)
Query: 30 IPVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVY 89
I V+ LLP G+ + LE REAT+ IK L+K+ YP+ LL D SY+F V Q A
Sbjct: 20 ILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQEAER 79
Query: 90 EELEDETRRLCDVRPFLPVLKLVTRSCDPGEK-LDSKIGVLIGKGLHEFDSLKDPEVNEF 148
EE DETRRLCD+R F P LK++ + EK L+ +IG IG + EFD +KDPEV +F
Sbjct: 80 EEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDMVKDPEVQDF 139
Query: 149 RRKMRKFSEEKILSLVGLSWMDWLKQTYPP--EHEPSIPENLEDKLYGGKLIVAVHF--- 203
RR + +E + S YPP E P +P+++ +KL G++IV +
Sbjct: 140 RRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVS 199
Query: 204 -ENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDE-----VSPYD--YVLQVSGRVE 255
N + ++ +++ + P +V AI+K+ E V Y Y+L+V G E
Sbjct: 200 PNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDE 259
Query: 256 YVFGDHPLIQFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAIEAAINRNSSNLPLPL 315
Y +PL Q++YIR+C+M +P+ +L+ + + + + R S+ P
Sbjct: 260 YFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRRISTATPYMN 319
Query: 316 PPKKTRIISHVWENNNPFQIVLVKGN--KLNTEETVKVHVRAGLFHGTELLCKTIVSSEV 373
T+ + W N+ +I ++ +N + K++VR G++HG E LC + + V
Sbjct: 320 GETSTKSL---WVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRV 376
Query: 374 SGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGK 433
N WNE L +DI I DLPR ARLC ++ +V K +K K +
Sbjct: 377 PCSNPR-WNEWLNYDIYIPDLPRAARLCLSICSV----KGRKGAK--------------E 417
Query: 434 VHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQTNPYTENATALHV 493
H P+AW N +FD+ L +G + L+ W P LE++LNP+G +NP E L +
Sbjct: 418 EHCPLAWGNINLFDYTDTLVSGKMALNLWP-VPHGLEDLLNPIGVTGSNPNKETP-CLEL 475
Query: 494 KFPENKKQPYYYPPFDKIIEKAAEIASSDSANVS-SRGG------------KKFLPVLKE 540
+F + P +IE+ A + S A S S G + LK
Sbjct: 476 EFDWFSSVVKF--PDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKA 533
Query: 541 ILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK 600
I RDPLS++ E E D +W+ R C I P+ LPKLLLS+KWN ++VAQ+ L++ WP
Sbjct: 534 ISTRDPLSEITEQEKDFLWSHRHYCVTI-PEILPKLLLSVKWNSRDEVAQMYCLVKDWPP 592
Query: 601 LPPREALELLDFNYPDQYVREYAVGCLRQ-MSDEELSQYLLQLVQVLKYEPFLDCALSRF 659
+ P +A+ELLD NYPD VR +AV CL + ++D++LSQYL+QLVQVLKYE +LD L RF
Sbjct: 593 IKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRF 652
Query: 660 LLERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKL 719
LL++AL N+RIG F FWHL+SE+H VS +FG++LE+YCR ++K L++QVEA+ KL
Sbjct: 653 LLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKL 712
Query: 720 KTLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYM 779
L ++K + + + +++ + +AL SPLNP L L +E+C+ M
Sbjct: 713 INLTDILKQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIM 772
Query: 780 DSKMKPLWLVYNNKVFGEDSV----GVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLR 835
S +PLWL + N + + +IFKNGDDLRQDMLTLQ++R+M+ +W+ GLDLR
Sbjct: 773 SSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLR 832
Query: 836 MLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLD 895
MLPYGCL+ GD GLIEVV S TI IQ + A FN L WLK+ N G+ D
Sbjct: 833 MLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGG-LKGALQFNSHTLHQWLKDKNKGEIYD 891
Query: 896 RAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRER 955
AI+ FT SCAGYCVA+++LGIGDRH+ NIMVK GQLFHIDFGH L + K KFG KRER
Sbjct: 892 AAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRER 951
Query: 956 VPFILTYDFIHVIQQG--KTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLP 1013
VPF+LT DF+ VI +G + T +F RF++ C AYL +R+H NLFI LF++ML +G+P
Sbjct: 952 VPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMP 1011
Query: 1014 ELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRK 1066
EL S DI Y++ +LAL K+E+EAL+ F ++ ++A WTTK++W+ HT+++
Sbjct: 1012 ELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQ 1064
>gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypeptide
[Homo sapiens]
Length = 1102
Score = 503 bits (1296), Expect = e-142
Identities = 326/910 (35%), Positives = 500/910 (54%), Gaps = 54/910 (5%)
Query: 184 IPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNE---LAIQKRLTIHGKEDE 240
+PE L K+ + + +H + +VSP+ P + + + K+ ++ +
Sbjct: 207 LPEYLWKKIANNCIFIVIHRSTTSQ--TIKVSPDDTPGAILQSFFTKMAKKKSLMDIPES 264
Query: 241 VSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRALPHFIL--VECCKIKKMYEQEMI 298
S D+VL+V GR EY+ G+ P+ FQ++R+C+ N H +L + ++ ++E
Sbjct: 265 QSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWP 324
Query: 299 AIEAAINRNSSNLPLPLPPKKTRIISHV--WENNNPFQIVLVKGNKL-----NTEETVKV 351
++ + L + K + V W+ + F+ V ++G + NT+ TV
Sbjct: 325 LVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFR-VKIRGIDIPVLPRNTDLTV-- 381
Query: 352 HVRAGLFHGTELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKV 411
V A + HG ++LC+ S + + + +WN LEF I I DLP+ A L +Y
Sbjct: 382 FVEANIQHGQQVLCQRRTSPKPFTE-EVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPA 440
Query: 412 KTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWS-SFPDELE 470
+ K++ +PS GKV + +VN ++ D + LR G+ +LH W S E +
Sbjct: 441 LSSKASAE-SPSS----ESKGKVQL-LYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQ 494
Query: 471 EMLNPMG-TVQTNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSR 529
N T TNP EN+ ++ + +N P P + + ++ N
Sbjct: 495 GSFNADKLTSATNPDKENSMSISILL-DNYCHPIALPKHQPTPDPEGDRVRAEMPN---- 549
Query: 530 GGKKFLPVLKEILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVA 589
+ L+ I+ DPL+ L + +L+W R + + P++ PKL S+KW + E VA
Sbjct: 550 ---QLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLK-HPKAYPKLFSSVKWGQQEIVA 605
Query: 590 ---QLQALLQIWPK--LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQ 644
QL A ++W + L ++LLD N+ D+ VR AV L + D+++ YLLQLVQ
Sbjct: 606 KTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQ 665
Query: 645 VLKYEPFLDCALSRFLLERALGNRRIGQFLFWHLRSEV-HIPAVSVQFGVILEAYCRG-S 702
+K+EP+ D AL+RFLL+R L N+RIG FLFW LRSE+ +F VILEAY RG
Sbjct: 666 AVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCG 725
Query: 703 VGHMKVLSKQVEALNKLKTLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQS-- 760
+ ++QV+ + L+ + IK ++ + + + LKQ S L
Sbjct: 726 TAMLHDFTQQVQVIEMLQKVTLDIK--SLSAEKYDVSSQVISQLKQKLENLQNSQLPESF 783
Query: 761 --PLNPCVILSELYVEKCKYMDSKMKPLWLVY---NNKVFGEDSVGVIFKNGDDLRQDML 815
P +P + L +EKCK M SK KPLWL + + +++G+IFK+GDDLRQDML
Sbjct: 784 RVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDML 843
Query: 816 TLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAA 875
LQ+LR+M+ +W+ LDL +LPYGC++TGD+ G+IE+V + TIA IQ S V A
Sbjct: 844 ILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQ--QSTVGNTGA 901
Query: 876 FNKDALLNWLKEYNSGDD-LDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLF 934
F + L +WLKE + ++ A+E F SCAGYCVA++VLGIGDRH+DNIM+ +TG LF
Sbjct: 902 FKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLF 961
Query: 935 HIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILR 994
HIDFGHILGN+KS GI +ERVPF+LT DF+ V+ + F +F+ C AYL LR
Sbjct: 962 HIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALR 1021
Query: 995 RHGNLFITLFALMLTAGLPELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESWT 1054
H NL I LF++ML G+P+LTS +DI+Y++D+L +GK+EE+A K F + + + WT
Sbjct: 1022 HHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWT 1081
Query: 1055 TKVNWMAHTV 1064
+ NW H V
Sbjct: 1082 VQFNWFLHLV 1091
>gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptide
[Homo sapiens]
Length = 1686
Score = 360 bits (924), Expect = 4e-99
Identities = 259/775 (33%), Positives = 399/775 (51%), Gaps = 53/775 (6%)
Query: 304 INRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTE---ETVKVHVRAGLFHG 360
++ NS P + ++ + W Q + + +++ K ++ L H
Sbjct: 658 LHANSGRSPTDCA-QSSKSVKEAWTTTEQLQFTIFAAHGISSNWVSNYEKYYLICSLSHN 716
Query: 361 TELLCKTIVSSEVSGKNDHI----WNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKS 416
+ L K I S +V + W+E + F I I LP + L ++ +L++ S
Sbjct: 717 GKDLFKPIQSKKVGTYKNFFYLIKWDELIIFPIQISQLPLESVLHLTLFGILNQ----SS 772
Query: 417 TKTINPSKYQTIRKA-GKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNP 475
+ + +K + +A GKV P+ FDFK L G +L+ W+S +
Sbjct: 773 GSSPDSNKQRKGPEALGKVSLPL-------FDFKRFLTCGTKLLYLWTS-----SHTNSV 820
Query: 476 MGTVQTNPYTENATALHVKFPENKKQPYYYPP-FDKIIEKAAEIASSDSANVSSRGGKKF 534
GTV Y L V FP Y P D+ I + + + ++ GK
Sbjct: 821 PGTVTKKGYVMERIVLQVDFPSPAFDIIYTTPQVDRSIIQQHNLETLEN----DIKGK-- 874
Query: 535 LPVLKEILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQAL 594
L +IL +D L + + +W R C + P LPK+L S K ++A+ +L
Sbjct: 875 ---LLDILHKDSSLGLSKEDKAFLWEKRYYCFK-HPNCLPKILASAPNWKWVNLAKTYSL 930
Query: 595 LQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDC 654
L WP L P ALELLD + DQ VR AV + +SD+EL+ L Q VQ LKYE +L+
Sbjct: 931 LHQWPALYPLIALELLDSKFADQEVRSLAVTWIEAISDDELTDLLPQFVQALKYEIYLNS 990
Query: 655 ALSRFLLERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVE 714
+L +FLL RALGN +I L+W L+ +H S ++ +L A SVG ++ E
Sbjct: 991 SLVQFLLSRALGNIQIAHNLYWLLKDALHDVQFSTRYEHVLGALL--SVGGKRLR----E 1044
Query: 715 ALNKLKTLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYRE----ALSDLQSPLNPCVILSE 770
L K L L+ A K+ +A G A L++S R + + PL P ++ E
Sbjct: 1045 ELLKQTKLVQLLGGVAEKVRQASG-SARQVVLQRSMERVQSFFQKNKCRLPLKPSLVAKE 1103
Query: 771 LYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEA 830
L ++ C + S PL + N + + V+FK G+DLRQDML LQM+++MD +W +
Sbjct: 1104 LNIKSCSFFSSNAVPLKVTMVNADPMGEEINVMFKVGEDLRQDMLALQMIKIMDKIWLKE 1163
Query: 831 GLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYN- 889
GLDLRM+ + CL+TG G++E+V S+T+ IQ+ +F L WL++YN
Sbjct: 1164 GLDLRMVIFKCLSTGRDRGMVELVPASDTLRKIQV---EYGVTGSFKDKPLAEWLRKYNP 1220
Query: 890 SGDDLDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKF 949
S ++ ++A E F SCAG CVA+YVLGI DRH+DNIM++ TG +FHIDFG LG+ +
Sbjct: 1221 SEEEYEKASENFIYSCAGCCVATYVLGICDRHNDNIMLRSTGHMFHIDFGKFLGHAQMFG 1280
Query: 950 GIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLT 1009
KR+R PF+LT D +VI G+ T +F F C AY ++R+ NLF+ L +LM+
Sbjct: 1281 SFKRDRAPFVLTSDMAYVINGGEK-PTIRFQLFVDLCCQAYNLIRKQTNLFLNLLSLMIP 1339
Query: 1010 AGLPELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTV 1064
+GLPELTS++D++Y++D+L ++ EA F + + +L S TK N+ H +
Sbjct: 1340 SGLPELTSIQDLKYVRDALQPQTTDAEATIFFTRLIESSL-GSIATKFNFFIHNL 1393
>gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide
[Homo sapiens]
Length = 1634
Score = 348 bits (892), Expect = 2e-95
Identities = 235/725 (32%), Positives = 376/725 (51%), Gaps = 51/725 (7%)
Query: 352 HVRAGLFHGTELLCKTIVS--SEVSGKNDH--IWNEPLEFDINICDLPRMARLCFAVYAV 407
++ L HG + LC + + + S H +W++ + F + + LPR LC +YA+
Sbjct: 653 YLSCSLSHGGKELCSPLQTRRAHFSKYLFHLIVWDQQICFPVQVNRLPRETLLCATLYAL 712
Query: 408 LDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPD 467
P K +V + WV T +F+F+ L G +L W + +
Sbjct: 713 ----------PIPPPGSSSEANKQRRVPEALGWVTTPLFNFRQVLTCGRKLLGLWPATQE 762
Query: 468 ELEEMLNPMGTVQT-NPYTENATALHVKFPENKKQ-PYYYPPFDKIIEKAAEIASSDSAN 525
NP N + ++ L + FP + + PP DK + + +
Sbjct: 763 ------NPSARWSAPNFHQPDSVILQIDFPTSAFDIKFTSPPGDKFSPRY------EFGS 810
Query: 526 VSSRGGKKFLPVLKEILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSI---KW 582
+ +K LK+I+ ++ L L + + +W R C SLP +L S +W
Sbjct: 811 LREEDQRK----LKDIMQKESLYWLTDADKKRLWEKRYYCHSEV-SSLPLVLASAPSWEW 865
Query: 583 NKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQL 642
L D+ LL+ W + ++AL LL +PDQ VR AV + +SD EL YL QL
Sbjct: 866 ACLPDI---YVLLKQWTHMNHQDALGLLHATFPDQEVRRMAVQWIGSLSDAELLDYLPQL 922
Query: 643 VQVLKYEPFLDCALSRFLLERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAY-CRG 701
VQ LKYE +LD L RFLL+RA+ + R+ + FW L+ + S+++ +L A C
Sbjct: 923 VQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKDGLKDSQFSIRYQYLLAALLCCC 982
Query: 702 SVGHMKVLSKQVEALNKLKTLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALS-DLQS 760
G + ++Q +N L L ++ A + + T L++ AL+ +
Sbjct: 983 GKGLREEFNRQCWLVNALAKLAQQVREAAPSARQG----ILRTGLEEVKQFFALNGSCRL 1038
Query: 761 PLNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQML 820
PL+P +++ + C Y +S PL L + N +++ VIFK GDDLRQDMLTLQM+
Sbjct: 1039 PLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRVIFKCGDDLRQDMLTLQMI 1098
Query: 821 RLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDA 880
R+M +W + GLD+RM+ + C +TG G++E++ +ET+ IQ+ +F
Sbjct: 1099 RIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHG---VTGSFKDRP 1155
Query: 881 LLNWLKEYNSGDD-LDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFG 939
L +WL+++N G+D ++A+E F SCAG CVA+YVLGI DRH+DNIM+K TG +FHIDFG
Sbjct: 1156 LADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTTGHMFHIDFG 1215
Query: 940 HILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNL 999
LG+ + IKR+R PF+ T D +VI G ++ +F F C AY ++R+H +L
Sbjct: 1216 RFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSS-RFHDFVDLCCQAYNLIRKHTHL 1274
Query: 1000 FITLFALMLTAGLPELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNW 1059
F+ L LML+ G+PEL+ ++D++Y+ D+L +E A F + + +L S TK+N+
Sbjct: 1275 FLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLIESSL-GSVATKLNF 1333
Query: 1060 MAHTV 1064
H +
Sbjct: 1334 FIHNL 1338
>gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptide
[Homo sapiens]
Length = 1445
Score = 282 bits (722), Expect = 1e-75
Identities = 208/703 (29%), Positives = 347/703 (49%), Gaps = 63/703 (8%)
Query: 401 CFAVYAVLDKVKTKKSTKTINPS--KYQTIRKAGKVHYPVAWVNTMVFD----------- 447
C + YA V + T +NP + + + P WV+ + F
Sbjct: 498 CNSFYADFQPVNVPRCTSYLNPGLPSHLSFTVYAAHNIPETWVHRINFPLEIKSLPRESM 557
Query: 448 -----FKGQLRTGDIILHSWSS---FPDE---LEEMLNPMGTVQTNPYTENAT------- 489
F T + L +W+ FP E L ML M T+Q+ P E T
Sbjct: 558 LTVKLFGIACATNNANLLAWTCLPLFPKEKSILGSMLFSM-TLQSEPPVEMITPGVWDVS 616
Query: 490 -----ALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKEILDR 544
L + FP + Y P + E + +R +K P+L
Sbjct: 617 QPSPVTLQIDFPATGWE--YMKPDSEENRSNLEEPLKECIKHIARLSQKQTPLL------ 668
Query: 545 DPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPR 604
L E + +W R C SLP +L S V+++ +L+ W P
Sbjct: 669 -----LSEEKKRYLWFYRFYCNNE-NCSLPLVLGSAPGWDERTVSEMHTILRRWTFSQPL 722
Query: 605 EALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERA 664
EAL LL ++PDQ +R+ AV L + ++EL +YL QLVQ +K+E L+ L + LL R+
Sbjct: 723 EALGLLTSSFPDQEIRKVAVQQLDNLLNDELLEYLPQLVQAVKFEWNLESPLVQLLLHRS 782
Query: 665 LGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEA--YCRGSVGHMKVLSKQVEALNKLKTL 722
L + ++ L+W L++ + + +L A +C G + + SK+ + + L +
Sbjct: 783 LQSIQVAHRLYWLLKNAENEAYFKSWYQKLLAALQFCAGKALNDE-FSKEQKLIKILGDI 841
Query: 723 NSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMDSK 782
+K + + K+ + + + + ++ PLNP + + + + C Y S
Sbjct: 842 GERVKSASDHQRQEVLKKEIG---RLEEFFQDVNTCHLPLNPALCIKGIDHDACSYFTSN 898
Query: 783 MKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCL 842
PL + + N ++ +IFK GDDLRQDML LQ++++MD +W + GLD++M+ Y CL
Sbjct: 899 ALPLKITFINANPMGKNISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCL 958
Query: 843 ATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNS-GDDLDRAIEEF 901
+TG GL+++V + T+A I +S + ++ + W ++N D ++A+ F
Sbjct: 959 STGKDQGLVQMVPDAVTLAKIHRHSGLIGP---LKENTIKKWFSQHNHLKADYEKALRNF 1015
Query: 902 TLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILT 961
SCAG+CV +++LG+ DRH+DNIM+ K+G +FHIDFG LG+ ++ GIKR+R PFI T
Sbjct: 1016 FYSCAGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFT 1075
Query: 962 YDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDI 1021
+ + I +G N + F F + C AY I+R+H L + L +ML AGLPEL+ ++D+
Sbjct: 1076 SEMEYFITEGGK-NPQHFQDFVELCCRAYNIIRKHSQLLLNLLEMMLYAGLPELSGIQDL 1134
Query: 1022 QYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTV 1064
+Y+ ++L ++ EA F +K E+L E + K+N + HT+
Sbjct: 1135 KYVYNNLRPQDTDLEATSHFTKKIKESL-ECFPVKLNNLIHTL 1176
>gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapiens]
Length = 887
Score = 171 bits (433), Expect = 3e-42
Identities = 128/421 (30%), Positives = 209/421 (49%), Gaps = 47/421 (11%)
Query: 652 LDCALSRFLLERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSK 711
L+ L FL+ RA N + +L+W++ E + E Y + L K
Sbjct: 471 LEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLK 530
Query: 712 QVEALNKLKTL--------NSLIKL-NAVKL---NRAKGKEAMHTCLKQSAYREALSDLQ 759
+++ +++L + L+ L AV+ NR K E + L + + LSD++
Sbjct: 531 GDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNE-KMNLSDVE 589
Query: 760 S---PLNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLT 816
PL P V + + E S + P L + + G+ VIFK+GDDLRQD L
Sbjct: 590 LIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGK--YPVIFKHGDDLRQDQLI 647
Query: 817 LQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAF 876
LQ++ LMD L ++ LDL++ PY LAT + G ++ + S A
Sbjct: 648 LQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQ------------SVPVAEVLD 695
Query: 877 NKDALLNWLKEYNSGDDLDRAI-----EEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTG 931
+ ++ N+ ++Y ++ I + + SCAGYCV +Y+LG+GDRH DN+++ KTG
Sbjct: 696 TEGSIQNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTG 755
Query: 932 QLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTG-NTEKFGRFRQCCEDAY 990
+LFHIDFG+ILG R+ P + +G G +E++ FR+ C A+
Sbjct: 756 KLFHIDFGYILG---------RDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAF 806
Query: 991 LILRRHGNLFITLFALMLTAGLPE--LTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEA 1048
L LRR+ NL + LF+LM+ A +P+ L K ++ ++D L S+EEA+ + DE+
Sbjct: 807 LHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDES 866
Query: 1049 L 1049
+
Sbjct: 867 V 867
Score = 79.3 bits (194), Expect = 2e-14
Identities = 47/116 (40%), Positives = 61/116 (52%), Gaps = 1/116 (0%)
Query: 538 LKEILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQI 597
L I+ P QL E DL+W R ++L K L + W+ ++ Q LL
Sbjct: 296 LNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQ-EKALTKFLKCVNWDLPQEAKQALELLGK 354
Query: 598 WPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLD 653
W + ++LELL +Y + VR YAV LRQ DE+L YLLQLVQ LKYE F D
Sbjct: 355 WKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDD 410
>gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1 [Homo
sapiens]
Length = 854
Score = 115 bits (287), Expect = 3e-25
Identities = 123/501 (24%), Positives = 204/501 (40%), Gaps = 67/501 (13%)
Query: 580 IKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQ-YVREYAVGCLRQMSDEELSQY 638
+ W+ ++ A + + W P L YP +Y V LR + + Y
Sbjct: 346 VTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFY 405
Query: 639 LLQLVQVLKYEPFLDCALSRFLLERALGNRRIGQFLFWHLRSEVHIPAVSVQ----FGVI 694
+ Q+VQ L+Y+ + ++L A ++ + W++++ +++ Q G +
Sbjct: 406 IPQIVQALRYDKM--GYVREYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDL 463
Query: 695 LEAYCRGSVGHMKVLSK-----QVEALNKLKTLNSLIKLNAVKLNRAKGKEAMHTCLKQS 749
L+ G + +K + + NK+ ++++IK KG E CL
Sbjct: 464 LDQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIK------PYPKGDERKKACLSAL 517
Query: 750 AYREALSDLQSPLNPCVILSELYVEKCKYMDSKMKPLWLV-YNNKVFGEDSV-------- 800
+ + P NP I+ ++ + M S K +L + K G +
Sbjct: 518 SEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCR 577
Query: 801 --------------------GVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG 840
IFK GDD RQDML LQ++ L +++ GLDL + PY
Sbjct: 578 SDSEDECSTQEADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYR 637
Query: 841 CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE 900
+AT G+IE + T D ++ F + GD+ A ++
Sbjct: 638 VVATAPGCGVIECIPDC-TSRDQLGRQTDFGMYDYFTR----------QYGDESTLAFQQ 686
Query: 901 ----FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERV 956
F S A Y + ++L I DRH+ NIM+ K G + HIDFG + F+S G
Sbjct: 687 ARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFM---FESSPGGNLGWE 743
Query: 957 PFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELT 1016
P I D + +I GK T F F + C YL +R + + ++L LML GLP
Sbjct: 744 PDIKLTDEMVMIMGGKMEAT-PFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFR 802
Query: 1017 SVKDIQYLKDSLALGKSEEEA 1037
+ I+ LK + +E EA
Sbjct: 803 G-QTIKLLKHRFSPNMTEREA 822
>gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform 2
[Homo sapiens]
Length = 2044
Score = 115 bits (287), Expect = 3e-25
Identities = 123/501 (24%), Positives = 204/501 (40%), Gaps = 67/501 (13%)
Query: 580 IKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQ-YVREYAVGCLRQMSDEELSQY 638
+ W+ ++ A + + W P L YP +Y V LR + + Y
Sbjct: 1536 VTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFY 1595
Query: 639 LLQLVQVLKYEPFLDCALSRFLLERALGNRRIGQFLFWHLRSEVHIPAVSVQ----FGVI 694
+ Q+VQ L+Y+ + ++L A ++ + W++++ +++ Q G +
Sbjct: 1596 IPQIVQALRYDKM--GYVREYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDL 1653
Query: 695 LEAYCRGSVGHMKVLSK-----QVEALNKLKTLNSLIKLNAVKLNRAKGKEAMHTCLKQS 749
L+ G + +K + + NK+ ++++IK KG E CL
Sbjct: 1654 LDQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIK------PYPKGDERKKACLSAL 1707
Query: 750 AYREALSDLQSPLNPCVILSELYVEKCKYMDSKMKPLWLV-YNNKVFGEDSV-------- 800
+ + P NP I+ ++ + M S K +L + K G +
Sbjct: 1708 SEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCR 1767
Query: 801 --------------------GVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG 840
IFK GDD RQDML LQ++ L +++ GLDL + PY
Sbjct: 1768 SDSEDECSTQEADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYR 1827
Query: 841 CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE 900
+AT G+IE + T D ++ F + GD+ A ++
Sbjct: 1828 VVATAPGCGVIECIPDC-TSRDQLGRQTDFGMYDYFTR----------QYGDESTLAFQQ 1876
Query: 901 ----FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERV 956
F S A Y + ++L I DRH+ NIM+ K G + HIDFG + F+S G
Sbjct: 1877 ARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFM---FESSPGGNLGWE 1933
Query: 957 PFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELT 1016
P I D + +I GK T F F + C YL +R + + ++L LML GLP
Sbjct: 1934 PDIKLTDEMVMIMGGKMEAT-PFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFR 1992
Query: 1017 SVKDIQYLKDSLALGKSEEEA 1037
+ I+ LK + +E EA
Sbjct: 1993 G-QTIKLLKHRFSPNMTEREA 2012
>gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo
sapiens]
Length = 828
Score = 104 bits (259), Expect = 5e-22
Identities = 79/262 (30%), Positives = 130/262 (49%), Gaps = 20/262 (7%)
Query: 800 VGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSET 859
+ VI K GDDLRQ++L Q+L+ + +W++ + L + PY L SG+IE V + +
Sbjct: 571 LSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVS 630
Query: 860 IADIQLNSSNVAAAAAFNKDALLNW-LKEYNS--GDDLDRAIEEFTLSCAGYCVASYVLG 916
I ++ S +LL++ L+E+ S + A F SCAGYC+ Y+L
Sbjct: 631 IHQVKKQSQL----------SLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQ 680
Query: 917 IGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNT 976
+ DRH+ NI++ G + HIDFG IL + G E F LT +F+ V+ G G
Sbjct: 681 VKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGF--ETSAFKLTTEFVDVM-GGLDG-- 735
Query: 977 EKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAG-LPELTSVKDIQYLKDSLALGKSEE 1035
+ F ++ + R+H + + + +M LP I+ LK+ + +EE
Sbjct: 736 DMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEE 795
Query: 1036 EALKQFKQKFDEALRESWTTKV 1057
+ +Q D ++R S TTK+
Sbjct: 796 QLQLLVEQMVDGSMR-SITTKL 816
>gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase
type 3 alpha [Homo sapiens]
Length = 286
Score = 74.3 bits (181), Expect = 6e-13
Identities = 50/141 (35%), Positives = 71/141 (50%), Gaps = 15/141 (10%)
Query: 803 IFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIAD 862
IFK GDD RQDML LQ++ L +++ GLDL + PY +AT G+IE + T D
Sbjct: 54 IFKLGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDC-TSRD 112
Query: 863 IQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE----FTLSCAGYCVASYVLGIG 918
++ F + GD+ A ++ F S A Y + ++L I
Sbjct: 113 QLGRQTDFGMYDYFTR----------QYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIK 162
Query: 919 DRHSDNIMVKKTGQLFHIDFG 939
DRH+ NIM+ K G + HIDFG
Sbjct: 163 DRHNGNIMLDKKGHIIHIDFG 183
>gi|13654237 protein kinase, DNA-activated, catalytic polypeptide
isoform 1 [Homo sapiens]
Length = 4128
Score = 64.7 bits (156), Expect = 4e-10
Identities = 61/222 (27%), Positives = 96/222 (43%), Gaps = 57/222 (25%)
Query: 803 IFKNGDDLRQDMLTLQMLRLMD-LLWKEAGLDLRMLP---YGCLATGDRSGLIEVVSTSE 858
+ K G+DLRQD Q+ ++M+ +L +++ R L Y + R GLIE + +
Sbjct: 3751 LVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTV 3810
Query: 859 TIADIQLNSSNVAAAAAFNKDALL------NWLKEYNSGDD------------------- 893
T+ D+ LN+ + AA+ D +WL + + D
Sbjct: 3811 TLKDLLLNTMSQEEKAAYLSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTS 3870
Query: 894 ------------LDRAI--------------EEFTLSCAGYCVASYVLGIGDRHSDNIMV 927
L RA F S A C++ ++LGIGDRH +N MV
Sbjct: 3871 FRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMV 3930
Query: 928 -KKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVI 968
+TG + IDFGH G+ ++F E +PF LT FI+++
Sbjct: 3931 AMETGGVIGIDFGHAFGS-ATQFLPVPELMPFRLTRQFINLM 3971
>gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens]
Length = 1708
Score = 58.5 bits (140), Expect = 3e-08
Identities = 61/246 (24%), Positives = 103/246 (41%), Gaps = 47/246 (19%)
Query: 803 IFKNGDDLRQDMLTLQMLRLMDLLWKE----AGLDLRMLPYGCLATGDRSGLIEVVSTSE 858
+ K DDLRQD + Q+ ++ + L + L + Y + RSG++E + +
Sbjct: 1367 LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTV 1426
Query: 859 TIADIQLNSSNVA---------AAAAFNKDALLNWLKEYNSGDD---------------- 893
I + +N+ + A +A K + K + +
Sbjct: 1427 PIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYF 1486
Query: 894 -----LDRAIE-----EFTLSCAGYCVASYVLGIGDRHSDNIMV-KKTGQLFHIDFGHIL 942
LD AI +T S A + Y+LG+GDRH NI++ +++ +L HID G +
Sbjct: 1487 CMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG--V 1544
Query: 943 GNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFIT 1002
+ K E VPF LT D + + G T G FR+CCE ++R +T
Sbjct: 1545 AFEQGKILPTPETVPFRLTRDIVDGM-----GITGVEGVFRRCCEKTMEVMRNSQETLLT 1599
Query: 1003 LFALML 1008
+ ++L
Sbjct: 1600 IVEVLL 1605
>gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens]
Length = 3056
Score = 58.5 bits (140), Expect = 3e-08
Identities = 61/246 (24%), Positives = 103/246 (41%), Gaps = 47/246 (19%)
Query: 803 IFKNGDDLRQDMLTLQMLRLMDLLWKE----AGLDLRMLPYGCLATGDRSGLIEVVSTSE 858
+ K DDLRQD + Q+ ++ + L + L + Y + RSG++E + +
Sbjct: 2715 LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTV 2774
Query: 859 TIADIQLNSSNVA---------AAAAFNKDALLNWLKEYNSGDD---------------- 893
I + +N+ + A +A K + K + +
Sbjct: 2775 PIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYF 2834
Query: 894 -----LDRAIE-----EFTLSCAGYCVASYVLGIGDRHSDNIMV-KKTGQLFHIDFGHIL 942
LD AI +T S A + Y+LG+GDRH NI++ +++ +L HID G +
Sbjct: 2835 CMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG--V 2892
Query: 943 GNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFIT 1002
+ K E VPF LT D + + G T G FR+CCE ++R +T
Sbjct: 2893 AFEQGKILPTPETVPFRLTRDIVDGM-----GITGVEGVFRRCCEKTMEVMRNSQETLLT 2947
Query: 1003 LFALML 1008
+ ++L
Sbjct: 2948 IVEVLL 2953
>gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, partial
[Homo sapiens]
Length = 2934
Score = 58.5 bits (140), Expect = 3e-08
Identities = 61/246 (24%), Positives = 103/246 (41%), Gaps = 47/246 (19%)
Query: 803 IFKNGDDLRQDMLTLQMLRLMDLLWKE----AGLDLRMLPYGCLATGDRSGLIEVVSTSE 858
+ K DDLRQD + Q+ ++ + L + L + Y + RSG++E + +
Sbjct: 2593 LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTV 2652
Query: 859 TIADIQLNSSNVA---------AAAAFNKDALLNWLKEYNSGDD---------------- 893
I + +N+ + A +A K + K + +
Sbjct: 2653 PIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYF 2712
Query: 894 -----LDRAIE-----EFTLSCAGYCVASYVLGIGDRHSDNIMV-KKTGQLFHIDFGHIL 942
LD AI +T S A + Y+LG+GDRH NI++ +++ +L HID G +
Sbjct: 2713 CMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG--V 2770
Query: 943 GNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFIT 1002
+ K E VPF LT D + + G T G FR+CCE ++R +T
Sbjct: 2771 AFEQGKILPTPETVPFRLTRDIVDGM-----GITGVEGVFRRCCEKTMEVMRNSQETLLT 2825
Query: 1003 LFALML 1008
+ ++L
Sbjct: 2826 IVEVLL 2831
>gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens]
Length = 3661
Score = 58.2 bits (139), Expect = 4e-08
Identities = 48/175 (27%), Positives = 79/175 (45%), Gaps = 15/175 (8%)
Query: 892 DDLDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMV-KKTGQLFHIDFGHILGNFKSKFG 950
D+ R + + S A + Y++G+GDRH DN+++ TG++ HID+ K K
Sbjct: 2308 DEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFE--KGKSL 2365
Query: 951 IKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTA 1010
E+VPF +T + + G T G FR CE I+RR +TL +
Sbjct: 2366 RVPEKVPFRMTQNI-----ETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYD 2420
Query: 1011 GLPELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESWTT------KVNW 1059
L + T+ + + G + E+ KQ K++ + + S + KVNW
Sbjct: 2421 PLVDWTAGGEAGFAGAVYGGGGQQAES-KQSKREMEREITRSLFSSRVAEIKVNW 2474
>gi|4826730 FK506 binding protein 12-rapamycin associated protein 1
[Homo sapiens]
Length = 2549
Score = 56.2 bits (134), Expect = 2e-07
Identities = 69/276 (25%), Positives = 117/276 (42%), Gaps = 54/276 (19%)
Query: 763 NPCVILSELYVEKCKYMDSKMKP--LWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQML 820
N +I + + + SK +P L L+ +N G + V + K +DLRQD +Q+
Sbjct: 2147 NQPIIRIQSIAPSLQVITSKQRPRKLTLMGSN---GHEFV-FLLKGHEDLRQDERVMQLF 2202
Query: 821 RLMDLLWKEAGLDLR----MLPYGCLATGDRSGLIEVVSTSETI----------ADIQLN 866
L++ L LR + Y + SGLI V +T+ I LN
Sbjct: 2203 GLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLN 2262
Query: 867 SSN---VAAAAAFNKDALLNWLKEYN------SGDDLDRAI--------------EEFTL 903
+ + A ++ L+ ++ + +GDDL + + +T
Sbjct: 2263 IEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTR 2322
Query: 904 SCAGYCVASYVLGIGDRHSDNIMVKK-TGQLFHIDFGHI--LGNFKSKFGIKRERVPFIL 960
S A + Y+LG+GDRH N+M+ + +G++ HIDFG + + KF E++PF L
Sbjct: 2323 SLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKF---PEKIPFRL 2379
Query: 961 TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRH 996
T + ++ T G +R C +LR H
Sbjct: 2380 TRMLTNAMEV-----TGLDGNYRITCHTVMEVLREH 2410
>gi|126032350 protein kinase, DNA-activated, catalytic polypeptide
isoform 2 [Homo sapiens]
Length = 4097
Score = 56.2 bits (134), Expect = 2e-07
Identities = 55/197 (27%), Positives = 86/197 (43%), Gaps = 38/197 (19%)
Query: 803 IFKNGDDLRQDMLTLQMLRLM------DLLWKEAGLDLRMLPYGCLATGD---------- 846
+ K G+DLRQD Q+ ++M D + L LR + + D
Sbjct: 3751 LVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSSDPRAPPCEYKD 3810
Query: 847 ----RSGLIEV---------VSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDD 893
SG +V + +ET+ + S V A D L ++ +
Sbjct: 3811 WLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPA------DLLKRAFVRMSTSPE 3864
Query: 894 LDRAIEE-FTLSCAGYCVASYVLGIGDRHSDNIMV-KKTGQLFHIDFGHILGNFKSKFGI 951
A+ F S A C++ ++LGIGDRH +N MV +TG + IDFGH G+ ++F
Sbjct: 3865 AFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGS-ATQFLP 3923
Query: 952 KRERVPFILTYDFIHVI 968
E +PF LT FI+++
Sbjct: 3924 VPELMPFRLTRQFINLM 3940
>gi|113430845 PREDICTED: similar to protein kinase, DNA-activated,
catalytic polypeptide [Homo sapiens]
Length = 4096
Score = 56.2 bits (134), Expect = 2e-07
Identities = 55/197 (27%), Positives = 86/197 (43%), Gaps = 38/197 (19%)
Query: 803 IFKNGDDLRQDMLTLQMLRLM------DLLWKEAGLDLRMLPYGCLATGD---------- 846
+ K G+DLRQD Q+ ++M D + L LR + + D
Sbjct: 3750 LVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSSDPRAPPCEYKD 3809
Query: 847 ----RSGLIEV---------VSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDD 893
SG +V + +ET+ + S V A D L ++ +
Sbjct: 3810 WLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPA------DLLKRAFVRMSTSPE 3863
Query: 894 LDRAIEE-FTLSCAGYCVASYVLGIGDRHSDNIMV-KKTGQLFHIDFGHILGNFKSKFGI 951
A+ F S A C++ ++LGIGDRH +N MV +TG + IDFGH G+ ++F
Sbjct: 3864 AFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGS-ATQFLP 3922
Query: 952 KRERVPFILTYDFIHVI 968
E +PF LT FI+++
Sbjct: 3923 VPELMPFRLTRQFINLM 3939
>gi|157266317 ataxia telangiectasia and Rad3 related protein [Homo
sapiens]
Length = 2644
Score = 49.3 bits (116), Expect = 2e-05
Identities = 57/225 (25%), Positives = 92/225 (40%), Gaps = 42/225 (18%)
Query: 805 KNGDDLRQDMLTLQMLRLMD-LLWKEAGL---DLRMLPYGCLATGDRSGLIEVVSTSETI 860
K DDLR+D ++ L++ L K+A +L + Y + D G+IE V+ + +
Sbjct: 2327 KPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGL 2386
Query: 861 ADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEEFTL----------------- 903
I K+ L + + + + EF L
Sbjct: 2387 RPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPD 2446
Query: 904 ------SCAGYC-------VASYVLGIGDRHSDNIMVKK-TGQLFHIDFGHILGNFKSKF 949
S + YC + Y+LG+GDRH +NI+ TG+ H+DF + L N F
Sbjct: 2447 PTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDF-NCLFNKGETF 2505
Query: 950 GIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILR 994
+ E VPF LT++ ++ G G G FR+ CE ++R
Sbjct: 2506 EVP-EIVPFRLTHNMVN--GMGPMGTE---GLFRRACEVTMRLMR 2544
>gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad3
related protein, partial [Homo sapiens]
Length = 386
Score = 49.3 bits (116), Expect = 2e-05
Identities = 57/225 (25%), Positives = 92/225 (40%), Gaps = 42/225 (18%)
Query: 805 KNGDDLRQDMLTLQMLRLMD-LLWKEAGL---DLRMLPYGCLATGDRSGLIEVVSTSETI 860
K DDLR+D ++ L++ L K+A +L + Y + D G+IE V+ + +
Sbjct: 69 KPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGL 128
Query: 861 ADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEEFTL----------------- 903
I K+ L + + + + EF L
Sbjct: 129 RPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPD 188
Query: 904 ------SCAGYC-------VASYVLGIGDRHSDNIMVKK-TGQLFHIDFGHILGNFKSKF 949
S + YC + Y+LG+GDRH +NI+ TG+ H+DF + L N F
Sbjct: 189 PTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDF-NCLFNKGETF 247
Query: 950 GIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILR 994
+ E VPF LT++ ++ G G G FR+ CE ++R
Sbjct: 248 EVP-EIVPFRLTHNMVN--GMGPMGTE---GLFRRACEVTMRLMR 286
>gi|110611228 utrophin [Homo sapiens]
Length = 3433
Score = 33.5 bits (75), Expect = 1.1
Identities = 44/190 (23%), Positives = 77/190 (40%), Gaps = 22/190 (11%)
Query: 152 MRKFSEEKILSLVGLSWMDWLKQTYPPEHEPSIPENLEDKLYGGKLIVAVHFENCQDVFS 211
+++ + EKIL + W++QT P + ++ N G AV + D+FS
Sbjct: 147 LQQTNSEKIL-------LSWVRQTTRPYSQVNVL-NFTTSWTDGLAFNAVLHRHKPDLFS 198
Query: 212 FQVSPNMNPIKVNELAIQKRLTIHGKEDEVSPYDYVLQVSGR---VEYVFGDHPLIQFQY 268
+ M+PI+ E A K T G E + P D +Q+ + + Y+ ++ Q
Sbjct: 199 WDKVVKMSPIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQV 258
Query: 269 IRNCVMN-RALPHFILVECCKIKKMYEQEMIAIEAAINRNSSNLPLPLPPKKTRIISHVW 327
+ + LP K KK E+E I I++ P P ++ V
Sbjct: 259 TIDAIREVETLPR-------KYKKECEEEAINIQSTAPEEEHESPRAETPS---TVTEVD 308
Query: 328 ENNNPFQIVL 337
+ + +QI L
Sbjct: 309 MDLDSYQIAL 318
>gi|4502015 A-kinase anchor protein 1 precursor [Homo sapiens]
Length = 903
Score = 33.1 bits (74), Expect = 1.4
Identities = 15/54 (27%), Positives = 28/54 (51%), Gaps = 4/54 (7%)
Query: 35 LLPTGIYIQLEVPREATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAV 88
+LP GI +++ V + + L+ Q H +P F+ L +D M+ C +Q +
Sbjct: 703 MLPDGITVEVIVVNQVNAGH----LFVQQHTHPTFHALRSLDQQMYLCYSQPGI 752
>gi|153792694 baculoviral IAP repeat-containing 6 [Homo sapiens]
Length = 4857
Score = 32.7 bits (73), Expect = 1.9
Identities = 18/57 (31%), Positives = 33/57 (57%), Gaps = 5/57 (8%)
Query: 711 KQVEALNKLKTLNSLIKLNAVKLNRAKGKEAMHTCLKQSA-----YREALSDLQSPL 762
+ + A+N+++ LN+L KLN+ NR KG+ + + A E+ +D+Q+PL
Sbjct: 755 ESLSAINQVEALNNLNKLNSALCNRRKGELESNLAVVNGANISVIQHESPADVQTPL 811
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 32.0 bits (71), Expect = 3.2
Identities = 27/83 (32%), Positives = 42/83 (50%), Gaps = 17/83 (20%)
Query: 882 LNWLKEYNSGDDLDRAIE---EFTLSCAGYCVASYVLGIGDRHS----------DNIMVK 928
L ++ EY +G DL I+ +F LS A + A +LG+ HS DNI++
Sbjct: 454 LFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLD 513
Query: 929 KTGQLFHIDFG----HILGNFKS 947
K G + DFG ++LG+ K+
Sbjct: 514 KDGHIKIADFGMCKENMLGDAKT 536
>gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens]
Length = 790
Score = 31.6 bits (70), Expect = 4.2
Identities = 17/63 (26%), Positives = 31/63 (49%), Gaps = 3/63 (4%)
Query: 104 PFLPVLKLVTRSCDPGEKLDSKIGVLIGKGLHEFDSLKDPEVNE---FRRKMRKFSEEKI 160
P P+ ++ D GE + + + G+GL FD + D E E +K+ F ++K+
Sbjct: 283 PGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKV 342
Query: 161 LSL 163
+L
Sbjct: 343 YTL 345
>gi|148277111 oncomodulin-like [Homo sapiens]
Length = 109
Score = 30.4 bits (67), Expect = 9.3
Identities = 18/45 (40%), Positives = 27/45 (60%), Gaps = 2/45 (4%)
Query: 1009 TAGLPELTS--VKDIQYLKDSLALGKSEEEALKQFKQKFDEALRE 1051
T+GL ++++ VKD+ D+ G +EE LK F QKF+ RE
Sbjct: 33 TSGLSKMSASQVKDVFRFIDNDQSGYLDEEELKFFLQKFESGARE 77
>gi|147906122 oncomodulin [Homo sapiens]
Length = 109
Score = 30.4 bits (67), Expect = 9.3
Identities = 18/45 (40%), Positives = 27/45 (60%), Gaps = 2/45 (4%)
Query: 1009 TAGLPELTS--VKDIQYLKDSLALGKSEEEALKQFKQKFDEALRE 1051
T+GL ++++ VKD+ D+ G +EE LK F QKF+ RE
Sbjct: 33 TSGLSKMSANQVKDVFRFIDNDQSGYLDEEELKFFLQKFESGARE 77
>gi|158534055 round spermatid basic protein 1-like [Homo sapiens]
Length = 846
Score = 30.4 bits (67), Expect = 9.3
Identities = 15/40 (37%), Positives = 22/40 (55%), Gaps = 5/40 (12%)
Query: 622 YAVGCLRQMS-----DEELSQYLLQLVQVLKYEPFLDCAL 656
Y G +RQ+S DEE+ Y + + +L+ PFL C L
Sbjct: 458 YRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTL 497
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,343,973
Number of Sequences: 37866
Number of extensions: 1791317
Number of successful extensions: 3928
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 3806
Number of HSP's gapped (non-prelim): 64
length of query: 1070
length of database: 18,247,518
effective HSP length: 113
effective length of query: 957
effective length of database: 13,968,660
effective search space: 13368007620
effective search space used: 13368007620
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.