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Search of human proteins with 13376842
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13376842 tankyrase, TRF1-interacting ankyrin-related
ADP-ribose polymerase 2 [Homo sapiens]
(1166 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 2357 0.0
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 1958 0.0
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 324 3e-88
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 308 3e-83
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 308 3e-83
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 308 3e-83
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 303 8e-82
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 303 8e-82
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 303 8e-82
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 303 8e-82
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 303 8e-82
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 248 2e-65
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 236 7e-62
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 211 2e-54
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 206 1e-52
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 201 4e-51
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 166 1e-40
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 164 6e-40
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 159 1e-38
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 159 1e-38
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 142 1e-33
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 142 1e-33
gi|34304381 inversin isoform a [Homo sapiens] 139 2e-32
gi|34304379 inversin isoform b [Homo sapiens] 139 2e-32
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 137 5e-32
gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform... 136 1e-31
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 130 6e-30
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 130 7e-30
gi|116534990 ankyrin-like protein 1 [Homo sapiens] 129 2e-29
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 127 5e-29
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 2357 bits (6108), Expect = 0.0
Identities = 1166/1166 (100%), Positives = 1166/1166 (100%)
Query: 1 MSGRRCAGGGAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKST 60
MSGRRCAGGGAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKST
Sbjct: 1 MSGRRCAGGGAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKST 60
Query: 61 PLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNAR 120
PLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNAR
Sbjct: 61 PLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNAR 120
Query: 121 DNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDE 180
DNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDE
Sbjct: 121 DNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDE 180
Query: 181 LLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAK 240
LLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAK
Sbjct: 181 LLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAK 240
Query: 241 DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG 300
DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG
Sbjct: 241 DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG 300
Query: 301 ADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKH 360
ADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKH
Sbjct: 301 ADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKH 360
Query: 361 PQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVV 420
PQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVV
Sbjct: 361 PQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVV 420
Query: 421 KHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQL 480
KHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQL
Sbjct: 421 KHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQL 480
Query: 481 LQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVS 540
LQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVS
Sbjct: 481 LQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVS 540
Query: 541 VVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAA 600
VVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAA
Sbjct: 541 VVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAA 600
Query: 601 AKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLAR 660
AKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLAR
Sbjct: 601 AKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLAR 660
Query: 661 VKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAA 720
VKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAA
Sbjct: 661 VKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAA 720
Query: 721 SYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQT 780
SYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQT
Sbjct: 721 SYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQT 780
Query: 781 PLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASS 840
PLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASS
Sbjct: 781 PLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASS 840
Query: 841 LDNLSGSFSELSSVVSSSGTEGASSLEKKEVPGVDFSITQFVRNLGLEHLMDIFEREQIT 900
LDNLSGSFSELSSVVSSSGTEGASSLEKKEVPGVDFSITQFVRNLGLEHLMDIFEREQIT
Sbjct: 841 LDNLSGSFSELSSVVSSSGTEGASSLEKKEVPGVDFSITQFVRNLGLEHLMDIFEREQIT 900
Query: 901 LDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQGLNPYLTLNTSGSGTILIDLSP 960
LDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQGLNPYLTLNTSGSGTILIDLSP
Sbjct: 901 LDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQGLNPYLTLNTSGSGTILIDLSP 960
Query: 961 DDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEEN 1020
DDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEEN
Sbjct: 961 DDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEEN 1020
Query: 1021 HNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTG 1080
HNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTG
Sbjct: 1021 HNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTG 1080
Query: 1081 CPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYV 1140
CPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYV
Sbjct: 1081 CPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYV 1140
Query: 1141 IYRGEQAYPEYLITYQIMRPEGMVDG 1166
IYRGEQAYPEYLITYQIMRPEGMVDG
Sbjct: 1141 IYRGEQAYPEYLITYQIMRPEGMVDG 1166
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 1958 bits (5072), Expect = 0.0
Identities = 950/1156 (82%), Positives = 1049/1156 (90%), Gaps = 9/1156 (0%)
Query: 8 GGGAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAG 67
G GAA AV A REL EACRNGDV RVKRLV VN++D AGRKS+PLHFAAG
Sbjct: 166 GPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAG 225
Query: 68 FGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTP 127
FGRKDVVE+LLQ GANV ARDDGGLIPLHNACSFGHAEVV+LLL GADPNARDNWNYTP
Sbjct: 226 FGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTP 285
Query: 128 LHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARS 187
LHEAAIKGKIDVCIVLLQHGA+P IRNTDG++ALDLADPSAKAVLTGEYKKDELLE+ARS
Sbjct: 286 LHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARS 345
Query: 188 GNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVP 247
GNEEK+MALLTPLNVNCHASDGRKSTPLHLAAGYNRV+IVQLLLQHGADVHAKDKG LVP
Sbjct: 346 GNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVP 405
Query: 248 LHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLN 307
LHNACSYGHYEVTELL+KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLS+GADPTL+N
Sbjct: 406 LHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVN 465
Query: 308 CHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETA 367
CH KSA+D+APTP+L+ERL YEFKGHSLLQAAREAD+ ++KK L+LE++NFK PQ+HETA
Sbjct: 466 CHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETA 525
Query: 368 LHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVN 427
LHCA AS +PKRKQ+ ELLLRKGAN+NEK K+F+TPLHVA+E+AHNDV+EV+ KH AK+N
Sbjct: 526 LHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMN 585
Query: 428 ALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISL 487
ALD LGQT+LHRAA GHLQTCRLLLSYG DP+IISLQGFTA QMGNE VQQ+L E +
Sbjct: 586 ALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPI 645
Query: 488 GNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQ 547
S+ D +LLEA+KAGD+ETVK+LC+ Q+VNCRD+EGR STPLHFAAGYNRVSVVEYLL
Sbjct: 646 RTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLH 705
Query: 548 HGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEI 607
HGADVHAKDKGGLVPLHNACSYGHYEVAELLV+HGA VNVADLWKFTPLHEAAAKGKYEI
Sbjct: 706 HGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEI 765
Query: 608 CKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSP 667
CKLLL+HGADPTKKNRDGNTPLDLVK+GDTDIQDLLRGDAALLDAAKKGCLARV+KL +P
Sbjct: 766 CKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTP 825
Query: 668 DNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDV 727
+N+NCRDTQGR+STPLHLAAGYNNLEVAEYLL+HGADVNAQDKGGLIPLHNAASYGHVD+
Sbjct: 826 ENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDI 885
Query: 728 AALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSA 787
AALLIKYN CVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPT+KNQEGQTPLDL +A
Sbjct: 886 AALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 945
Query: 788 DDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGS 847
DD+ ALL AMPP ALP+C+KPQ + +L S S+PS LSAASS+DNL+G
Sbjct: 946 DDIRALLIDAMPPEALPTCFKPQAT-------VVSASLISPASTPSCLSAASSIDNLTGP 998
Query: 848 FSELSSVVSSSGTEGASSLEKK--EVPGVDFSITQFVRNLGLEHLMDIFEREQITLDVLV 905
+EL+ +S+ +GA+ E+K EV G+D +I+QF+++LGLEHL DIFE EQITLDVL
Sbjct: 999 LAELAVGGASNAGDGAAGTERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLA 1058
Query: 906 EMGHKELKEIGINAYGHRHKLIKGVERLISGQQGLNPYLTLNTSGSGTILIDLSPDDKEF 965
+MGH+ELKEIGINAYGHRHKLIKGVERL+ GQQG NPYLT + GTIL+DL+P+DKE+
Sbjct: 1059 DMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEY 1118
Query: 966 QSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHAN 1025
QSVEEEMQST+REHRDGG+AGGIFNRYN+++IQKV NKKL ER+ HR+KEVSEENHNH N
Sbjct: 1119 QSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHN 1178
Query: 1026 ERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHK 1085
ERMLFHGSPF+NAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCP HK
Sbjct: 1179 ERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHK 1238
Query: 1086 DRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGE 1145
DRSCYICHRQ+LFCRVTLGKSFLQFS MKMAH+PPGHHSV GRPSVNGLA AEYVIYRGE
Sbjct: 1239 DRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGE 1298
Query: 1146 QAYPEYLITYQIMRPE 1161
QAYPEYLITYQIM+PE
Sbjct: 1299 QAYPEYLITYQIMKPE 1314
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 324 bits (830), Expect = 3e-88
Identities = 254/760 (33%), Positives = 360/760 (47%), Gaps = 72/760 (9%)
Query: 62 LHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARD 121
LH A+ G +VV LLQ ANV A G LH A G AEVV +L+ +GA+ NA+
Sbjct: 78 LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS 137
Query: 122 NWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA-----DPSAKAVLTGEY 176
+TPL+ AA + ++V LL +GA ++ DG T L +A D +L +
Sbjct: 138 QNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDT 197
Query: 177 K---KDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQH 233
K + L A ++ K ALL + N TPLH+AA Y + + LLL
Sbjct: 198 KGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNR 257
Query: 234 GADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVC 293
A V + D+ PLH A G+ + +LL+ GA ++A TPLH A +V
Sbjct: 258 AAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVV 317
Query: 294 SLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSL 353
+LL A P L N G S L A + D HL+
Sbjct: 318 EMLLDRAA-PILSKTKN---------------------GLSPLHMATQGD------HLNC 349
Query: 354 EMVNFKH-------PQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHV 406
+ +H + TALH AA + K + ++LL K AN N K TPLH+
Sbjct: 350 VQLLLQHNVPVDDVTNDYLTALHVAAHCGHYK---VAKVLLDKKANPNAKALNGFTPLHI 406
Query: 407 ASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQG 466
A +K V+E+++KH A + A+ G T +H AA+ GH+ L+ +G PN +++G
Sbjct: 407 ACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG 466
Query: 467 FTALQMGN-----ENVQQLLQEGISLGNSEADRQ--LLEAAKAGDVETVKKLCTV-QSVN 518
TAL M E V+ L+Q+G + D Q L +A+ G + V++L S N
Sbjct: 467 ETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPN 526
Query: 519 CRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELL 578
G TPLH +A V +LL HGA + K G PLH A YG EVA LL
Sbjct: 527 AATTSGY--TPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLL 584
Query: 579 VKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV-KDGDT 637
++ A + A TPLH AA ++ LLL GA P ++G TPL + K
Sbjct: 585 LQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQM 644
Query: 638 DIQDLL------------RGDAALLDAAKKGCLARVKKLSSPD-NVNCRDTQGRHSTPLH 684
DI L +G A++ AA++G + V L + NVN + G TPLH
Sbjct: 645 DIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGL--TPLH 702
Query: 685 LAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKW 744
LAA + + VAE L+ GA V+AQ K G PLH YG++ + L++++A VNA K
Sbjct: 703 LAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKN 762
Query: 745 AFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDL 784
+TPLH+AAQ+G T + +LL + A P G T L +
Sbjct: 763 GYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGI 802
Score = 268 bits (685), Expect = 2e-71
Identities = 220/716 (30%), Positives = 334/716 (46%), Gaps = 79/716 (11%)
Query: 98 ACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDG 157
A GH E +++G D N + LH A+ +G ++V LLQ A G
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 158 RTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLH 216
TAL +A + +G E + L+T NVN + +G TPL+
Sbjct: 108 NTALHIA--------------------SLAGQAEVVKVLVTNGANVNAQSQNG--FTPLY 145
Query: 217 LAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLW 276
+AA N +++V+ LL +GA + PL A GH +V LL+++ +
Sbjct: 146 MAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN----DTKGKV 201
Query: 277 QFTPLHEAASKNRVEVCSLLLSY----------GADPTLLNCHNKSAIDLAPTPQLKERL 326
+ LH AA K+ + +LLL G P + H + I++A T L
Sbjct: 202 RLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGN-INVA-TLLLNRAA 259
Query: 327 AYEFKGHS----LLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQI 382
A +F + L A++ + +K L + T LHC A S + +Q+
Sbjct: 260 AVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGH---EQV 316
Query: 383 CELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAY 442
E+LL + A I KTK L+PLH+A++ H + V+++++H V+ + N T+LH AA+
Sbjct: 317 VEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAH 376
Query: 443 CGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN-----VQQLLQEGISLG--NSEADRQ 495
CGH + ++LL +PN +L GFT L + + ++ LL+ G S+
Sbjct: 377 CGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTP 436
Query: 496 LLEAAKAGDVETVKKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA 554
+ AA G V V +L S N ++ G T LH AA + VV YL+Q GA V A
Sbjct: 437 IHVAAFMGHVNIVSQLMHHGASPNTTNVRGE--TALHMAARSGQAEVVRYLVQDGAQVEA 494
Query: 555 KDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQH 614
K K PLH + G ++ + L++ GA N A +TPLH +A +G ++ LL H
Sbjct: 495 KAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDH 554
Query: 615 GADPTKKNRDGNTPLDLV-KDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCR 673
GA + + G TPL + K G ++ +LL +A DAA K L
Sbjct: 555 GASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGL--------------- 599
Query: 674 DTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIK 733
TPLH+AA Y+N +VA LL GA +A K G PLH AA +D+A L++
Sbjct: 600 -------TPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLE 652
Query: 734 YNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADD 789
Y A NA + +H AAQ+G + +LLL A+ L N+ G TPL L + +D
Sbjct: 653 YGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQED 708
Score = 251 bits (640), Expect = 4e-66
Identities = 206/636 (32%), Positives = 303/636 (47%), Gaps = 49/636 (7%)
Query: 182 LESARSGNEEKMMALL-TPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAK 240
L +AR+G+ EK + + +++N +G + LHLA+ V++V LLQ A+V A
Sbjct: 46 LRAARAGHLEKALDYIKNGVDINICNQNGLNA--LHLASKEGHVEVVSELLQREANVDAA 103
Query: 241 DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG 300
K LH A G EV ++LV +GA VNA FTPL+ AA +N +EV LL G
Sbjct: 104 TKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNG 163
Query: 301 ADPTLLNCHNKSAIDLA----PTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMV 356
A +L + + +A + L + KG L A A K +L +
Sbjct: 164 ASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQ 223
Query: 357 NFKHPQTHE----TALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAH 412
N + T LH AA + + LLL + A ++ + +TPLHVAS++ +
Sbjct: 224 NDNNADVESKSGFTPLHIAA---HYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGN 280
Query: 413 NDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQM 472
++V++++ AK++A G T LH A GH Q +LL + G + L M
Sbjct: 281 ANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHM 340
Query: 473 GNEN-----VQQLLQEGISLGNSEAD--RQLLEAAKAGDVETVKKLCTVQS-VNCRDIEG 524
+ VQ LLQ + + + D L AA G + K L ++ N + + G
Sbjct: 341 ATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNG 400
Query: 525 RQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAV 584
TPLH A NR+ V+E LL+HGA + A + GL P+H A GH + L+ HGA
Sbjct: 401 --FTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGAS 458
Query: 585 VNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDL-VKDGDTDI-QDL 642
N ++ T LH AA G+ E+ + L+Q GA K +D TPL + + G DI Q L
Sbjct: 459 PNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQL 518
Query: 643 LRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHG 702
L+ A SP N T G TPLHL+A + +VA +LL HG
Sbjct: 519 LQQGA------------------SP---NAATTSGY--TPLHLSAREGHEDVAAFLLDHG 555
Query: 703 ADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCA 762
A ++ K G PLH AA YG ++VA LL++ +A +A K TPLH AA ++
Sbjct: 556 ASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVAL 615
Query: 763 LLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAM 798
LLL GA P + G TPL + + + + T +
Sbjct: 616 LLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLL 651
Score = 239 bits (610), Expect = 1e-62
Identities = 184/614 (29%), Positives = 276/614 (44%), Gaps = 38/614 (6%)
Query: 53 DTAGRKSTP-LHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLL 111
DT G+ P LH AA LLQN N G PLH A +G+ V LLL
Sbjct: 196 DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLL 255
Query: 112 RHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPS---- 167
A + + TPLH A+ +G ++ +LL GA+ + DG T L S
Sbjct: 256 NRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQ 315
Query: 168 --------AKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAA 219
A +L+ L A G+ + LL NV T LH+AA
Sbjct: 316 VVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAA 375
Query: 220 GYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFT 279
K+ ++LL A+ +AK PLH AC +V ELL+KHGA + A+ T
Sbjct: 376 HCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLT 435
Query: 280 PLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAA 339
P+H AA V + S L+ +GA P N ++A+ +A E + Y + + ++A
Sbjct: 436 PIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAK 495
Query: 340 READVTRIKKHLSLEMVNFKHPQTHE------------TALHCAAASPYPKRKQICELLL 387
+ D T + L + + T LH +A + + + LL
Sbjct: 496 AKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGH---EDVAAFLL 552
Query: 388 RKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQ 447
GA+++ TK+ TPLHVA++ +V ++++ A +A G T LH AA+ + +
Sbjct: 553 DHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQK 612
Query: 448 TCRLLLSYGCDPNIISLQGFTALQMGNENVQQ-----LLQEGISLG--NSEADRQLLEAA 500
LLL G P+ + G+T L + + Q LL+ G + + AA
Sbjct: 613 VALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAA 672
Query: 501 KAGDVETVKKLCTVQS-VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGG 559
+ G V+ V L + VN + G TPLH AA +RV+V E L+ GA V A+ K G
Sbjct: 673 QEGHVDMVSLLLGRNANVNLSNKSGL--TPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMG 730
Query: 560 LVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPT 619
PLH C YG+ ++ L++H A VN +TPLH+AA +G I +LLQ+ A P
Sbjct: 731 YTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPN 790
Query: 620 KKNRDGNTPLDLVK 633
+ +GNT L + +
Sbjct: 791 ELTVNGNTALGIAR 804
Score = 205 bits (522), Expect = 2e-52
Identities = 144/446 (32%), Positives = 219/446 (49%), Gaps = 40/446 (8%)
Query: 39 RVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNA 98
+V +++ +K N A TPLH A R V+E LL++GA++QA + GL P+H A
Sbjct: 381 KVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVA 440
Query: 99 CSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGR 158
GH +V+ L+ HGA PN + T LH AA G+ +V L+Q GA+ + D +
Sbjct: 441 AFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQ 500
Query: 159 TALDLADPSAKAVLTGEYKKD-------------ELLESARSGNEEKMMALLTPLNVNCH 205
T L ++ KA + + + L SAR G+E+ + A L +
Sbjct: 501 TPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHED-VAAFLLDHGASLS 559
Query: 206 ASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK 265
+ + TPLH+AA Y ++++ LLLQ A A K L PLH A Y + +V LL+
Sbjct: 560 ITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLD 619
Query: 266 HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKER 325
GA +A +TPLH AA KN++++ + LL YGAD + +++ L
Sbjct: 620 QGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHL--------- 670
Query: 326 LAYEFKGHSLLQAAREADVTRIKKHLSLEM-VNFKHPQTHETALHCAAASPYPKRKQICE 384
AA+E V + L VN + ++ T LH AA R + E
Sbjct: 671 ------------AAQEGHVDMVSLLLGRNANVNLSN-KSGLTPLHLAAQE---DRVNVAE 714
Query: 385 LLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCG 444
+L+ +GA+++ +TK TPLHV + +V +++H AKVNA G T LH+AA G
Sbjct: 715 VLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQG 774
Query: 445 HLQTCRLLLSYGCDPNIISLQGFTAL 470
H +LL PN +++ G TAL
Sbjct: 775 HTHIINVLLQNNASPNELTVNGNTAL 800
Score = 123 bits (308), Expect = 1e-27
Identities = 83/255 (32%), Positives = 118/255 (46%), Gaps = 12/255 (4%)
Query: 54 TAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRH 113
T + TPLH AA +G+ +V LLQ A+ A GL PLH A + + +V LLL
Sbjct: 561 TTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ 620
Query: 114 GADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAK---- 169
GA P+A YTPLH AA K ++D+ LL++GA+ G ++ LA
Sbjct: 621 GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMV 680
Query: 170 AVLTGEY------KKDELLESARSGNEEKMMALLTPLNVNCHASDGRKS--TPLHLAAGY 221
++L G K L + E+++ +N H K TPLH+ Y
Sbjct: 681 SLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHY 740
Query: 222 NRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPL 281
+KIV LLQH A V+AK K PLH A GH + +L+++ A N + + T L
Sbjct: 741 GNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTAL 800
Query: 282 HEAASKNRVEVCSLL 296
A + V L
Sbjct: 801 GIARRLGYISVVDTL 815
Score = 92.8 bits (229), Expect = 2e-18
Identities = 55/135 (40%), Positives = 76/135 (56%), Gaps = 3/135 (2%)
Query: 31 ACRNGDVERVKRLVTPE-KVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDD 89
A + G V+ V L+ VN + +G TPLH AA R +V E L+ GA+V A+
Sbjct: 671 AAQEGHVDMVSLLLGRNANVNLSNKSGL--TPLHLAAQEDRVNVAEVLVNQGAHVDAQTK 728
Query: 90 GGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAE 149
G PLH C +G+ ++VN LL+H A NA+ YTPLH+AA +G + VLLQ+ A
Sbjct: 729 MGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNAS 788
Query: 150 PTIRNTDGRTALDLA 164
P +G TAL +A
Sbjct: 789 PNELTVNGNTALGIA 803
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 308 bits (788), Expect = 3e-83
Identities = 265/817 (32%), Positives = 372/817 (45%), Gaps = 121/817 (14%)
Query: 31 ACRNGDVERV-KRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDD 89
A R G++++V + L +N+ + G + LH AA G +V+ LL G++V +
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNA--LHLAAKEGHVGLVQELLGRGSSVDSATK 74
Query: 90 GGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAE 149
G LH A G AEVV +L++ GA+ NA+ +TPL+ AA + IDV LL++GA
Sbjct: 75 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 134
Query: 150 PTIRNTDGRTALDLA----DPSAKAVLTGEYKKDEL----LESARSGNEEKMMALLTPLN 201
+ DG T L +A A A+L K ++ L A ++ K ALL
Sbjct: 135 QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ-- 192
Query: 202 VNCHASDGRKS-----------TPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHN 250
N H +D + TPLH+AA Y V + LLL GA V + + PLH
Sbjct: 193 -NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHV 251
Query: 251 ACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHN 310
A G+ + +LL+ G ++A TPLH AA +V LLL GA P L N
Sbjct: 252 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-PLLARTKN 310
Query: 311 KSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQT-----HE 365
G S L A + D KHL + K P +
Sbjct: 311 ---------------------GLSPLHMAAQGDHVECVKHL----LQHKAPVDDVTLDYL 345
Query: 366 TALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAK 425
TALH AA + + + +LLL K AN N + TPLH+A +K V+E++VK+ A
Sbjct: 346 TALHVAAHCGHYR---VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 402
Query: 426 VNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGN-----ENVQQL 480
+ A+ G T +H AA+ GHL LLL G P++ +++G TAL M E V+ L
Sbjct: 403 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 462
Query: 481 LQEGISLGNSEADRQ--LLEAAKAGDVETVKKL---------CTVQSVNCRDIEGRQS-- 527
L+ G + + Q L A++ G E V+ L T I R+
Sbjct: 463 LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQV 522
Query: 528 ---------------------TPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNA 566
TPLH AA Y + V + LLQ A + K GL PLH A
Sbjct: 523 DVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 582
Query: 567 CSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGN 626
Y + +VA LL++ GA + +TPLH AA K + +I LL +GA+ + G
Sbjct: 583 AHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV 642
Query: 627 TPLDLV-KDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHL 685
TPL L ++G TD+ LL A + + K L T LHL
Sbjct: 643 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL----------------------TSLHL 680
Query: 686 AAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWA 745
AA + + VA+ L +HGAD +A K G PL A YG+V + L+K A VNA K
Sbjct: 681 AAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNG 740
Query: 746 FTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPL 782
+TPLH+AAQ+G T + +LL HGA P G T L
Sbjct: 741 YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 777
Score = 261 bits (666), Expect = 4e-69
Identities = 215/665 (32%), Positives = 324/665 (48%), Gaps = 58/665 (8%)
Query: 182 LESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAK 240
L +AR+GN +K++ L +++N +G + LHLAA V +VQ LL G+ V +
Sbjct: 15 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNA--LHLAAKEGHVGLVQELLGRGSSVDSA 72
Query: 241 DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG 300
K LH A G EV ++LVK GA +NA FTPL+ AA +N ++V LL G
Sbjct: 73 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 132
Query: 301 ADPT-------------LLNCHNKSAIDLA----------PTPQLKERLAYEFKGHSLLQ 337
A+ + L HN++ L P + R LLQ
Sbjct: 133 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 192
Query: 338 AAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKT 397
ADV S MVN + ++ T LH AA + + LLL +GA ++
Sbjct: 193 NDHNADVQ------SKMMVN-RTTESGFTPLHIAA---HYGNVNVATLLLNRGAAVDFTA 242
Query: 398 KEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGC 457
+ +TPLHVAS++ + ++V++++ +++A G T LH AA GH Q LLL G
Sbjct: 243 RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA 302
Query: 458 DPNIISLQGFTALQMGNEN-----VQQLLQEGISLGNSEAD--RQLLEAAKAGDVETVKK 510
+ G + L M + V+ LLQ + + D L AA G K
Sbjct: 303 PLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKL 362
Query: 511 LCTVQS-VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSY 569
L ++ N R + G TPLH A NR+ V+E L+++GA + A + GL P+H A
Sbjct: 363 LLDKRANPNARALNG--FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 420
Query: 570 GHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPL 629
GH + LL+++GA +V ++ T LH AA G+ E+ + LL++GA + R+ TPL
Sbjct: 421 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPL 480
Query: 630 DLVKD-GDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCR----DTQGRHS---- 680
+ G T+I LL A DAA + + V+ + HS
Sbjct: 481 HIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK 540
Query: 681 ---TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNAC 737
TPLH+AA Y +L+VA+ LLQ A ++ K GL PLH AA Y + VA LL++ A
Sbjct: 541 KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS 600
Query: 738 VNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAA 797
+AT K +TPLH AA+K + Q+ + LL +GA+ + ++G TPL L S + + ++T
Sbjct: 601 PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 660
Query: 798 MPPSA 802
+ A
Sbjct: 661 LDKGA 665
Score = 248 bits (634), Expect = 2e-65
Identities = 226/743 (30%), Positives = 331/743 (44%), Gaps = 125/743 (16%)
Query: 98 ACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDG 157
A G+ + V L+ G D N + LH AA +G + + LL G+ G
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 158 RTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHL 217
TAL +A + +A E K + E A N+N + +G TPL++
Sbjct: 77 NTALHIASLAGQA----EVVKVLVKEGA---------------NINAQSQNG--FTPLYM 115
Query: 218 AAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK------------ 265
AA N + +V+ LL++GA+ + PL A GH + +L++
Sbjct: 116 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPAL 175
Query: 266 -------------------HGA------CVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG 300
H A VN FTPLH AA V V +LLL+ G
Sbjct: 176 HIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRG 235
Query: 301 ADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKH 360
A A+D G + L A + T + K L L+
Sbjct: 236 A-----------AVDFTAR-----------NGITPLHVASKRGNTNMVK-LLLDRGGQID 272
Query: 361 PQTHE--TALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEV 418
+T + T LHCAA S + Q+ ELLL +GA + +TK L+PLH+A++ H + V+
Sbjct: 273 AKTRDGLTPLHCAARSGHD---QVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 329
Query: 419 VVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQ 478
+++H+A V+ + T+LH AA+CGH + +LLL +PN +L GFT L +
Sbjct: 330 LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHI------ 383
Query: 479 QLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNR 538
A K ++ V +L + + I TP+H AA
Sbjct: 384 --------------------ACKKNRIK-VMELLVKYGASIQAITESGLTPIHVAAFMGH 422
Query: 539 VSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHE 598
+++V LLQ+GA + G LH A G EV L+++GA+V+ + TPLH
Sbjct: 423 LNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHI 482
Query: 599 AAAKGKYEICKLLLQHGADPTKKNRDGNTPLDL-VKDGDTDIQD-LLRGDAALLDAAKKG 656
A+ GK EI +LLLQH A P +G TPL + ++G D+ LL AA A KKG
Sbjct: 483 ASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKG 542
Query: 657 C--LARVKKLSSPDNVN-------CRDTQGRHS-TPLHLAAGYNNLEVAEYLLQHGADVN 706
L K S D D+ G++ TPLH+AA Y+N +VA LL+ GA +
Sbjct: 543 FTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH 602
Query: 707 AQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLA 766
A K G PLH AA + +A+ L+ Y A N K TPLH A+Q+G T + LLL
Sbjct: 603 ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 662
Query: 767 HGADPTLKNQEGQTPLDLVSADD 789
GA+ + + G T L L + +D
Sbjct: 663 KGANIHMSTKSGLTSLHLAAQED 685
Score = 229 bits (585), Expect = 9e-60
Identities = 184/597 (30%), Positives = 278/597 (46%), Gaps = 52/597 (8%)
Query: 60 TPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNA 119
TPLH AA +G +V LL GA V G+ PLH A G+ +V LLL G +A
Sbjct: 214 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 273
Query: 120 RDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKK- 178
+ TPLH AA G V +LL+ GA R +G + L +A G++ +
Sbjct: 274 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA-------AQGDHVEC 326
Query: 179 -DELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADV 237
LL+ ++ + L T LH+AA ++ +LLL A+
Sbjct: 327 VKHLLQHKAPVDDVTLDYL----------------TALHVAAHCGHYRVTKLLLDKRANP 370
Query: 238 HAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLL 297
+A+ PLH AC +V ELLVK+GA + A+ TP+H AA + + LLL
Sbjct: 371 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLL 430
Query: 298 SYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQA-AREADV-----TRIKKH- 350
GA P + N ++A+ +A E + + +L+ A ARE +R+ K
Sbjct: 431 QNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTE 490
Query: 351 -LSLEMVNFKHPQTHET----ALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLH 405
+ L + + HP T LH +A + + +LL GA + TK+ TPLH
Sbjct: 491 IVQLLLQHMAHPDAATTNGYTPLHISAREG---QVDVASVLLEAGAAHSLATKKGFTPLH 547
Query: 406 VASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQ 465
VA++ DV +++++ A ++ G T LH AA+ + + LLL G P+ +
Sbjct: 548 VAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN 607
Query: 466 GFTALQMGNENVQQLLQEGISLGNSEADRQLLE---------AAKAGDVETVKKLCTVQS 516
G+T L + + Q +Q +L N A+ ++ A++ G + V L +
Sbjct: 608 GYTPLHIAAKKNQ--MQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD-KG 664
Query: 517 VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAE 576
N T LH AA ++V+V + L +HGAD A K G PL AC YG+ ++
Sbjct: 665 ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVN 724
Query: 577 LLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVK 633
L+K GA VN +TPLH+AA +G I +LLQHGA P +GNT L + K
Sbjct: 725 FLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 781
Score = 181 bits (458), Expect = 5e-45
Identities = 141/480 (29%), Positives = 224/480 (46%), Gaps = 32/480 (6%)
Query: 39 RVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNA 98
RV +L+ ++ N A TPLH A R V+E L++ GA++QA + GL P+H A
Sbjct: 358 RVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 417
Query: 99 CSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGR 158
GH +V LLL++GA P+ + T LH AA G+++V LL++GA R + +
Sbjct: 418 AFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQ 477
Query: 159 TALDLADPSAK---------------AVLTGEYKKDELLESARSGNEEKMMALLTPLNVN 203
T L +A K A T Y + SAR G + LL +
Sbjct: 478 TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHI--SAREGQVDVASVLLEAGAAH 535
Query: 204 CHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELL 263
A+ + TPLH+AA Y + + +LLLQ A + K L PLH A Y + +V LL
Sbjct: 536 SLATK-KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 594
Query: 264 VKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLK 323
++ GA +A +TPLH AA KN++++ S LL+YGA+ ++ + + LA
Sbjct: 595 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 654
Query: 324 ERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCA----------AA 373
+ + + + + ++ +T + + VN T A A A
Sbjct: 655 DMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVA 714
Query: 374 SPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLG 433
Y K + LL++GAN+N KTK TPLH A+++ H ++ V+++H AK NA G
Sbjct: 715 CHYGNVKMV-NFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANG 773
Query: 434 QTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEAD 493
T+L A G++ L ++ T + NV + + E + + + E D
Sbjct: 774 NTALAIAKRLGYISVVDTLKVV---TEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGD 830
Score = 150 bits (378), Expect = 9e-36
Identities = 99/287 (34%), Positives = 140/287 (48%), Gaps = 22/287 (7%)
Query: 31 ACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDG 90
+ R G V+ L+ +S T + TPLH AA +G DV + LLQ A +
Sbjct: 516 SAREGQVDVASVLLEAGAAHSLATK-KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN 574
Query: 91 GLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEP 150
GL PLH A + + +V LLL GA P+A YTPLH AA K ++ + LL +GAE
Sbjct: 575 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 634
Query: 151 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGR 210
I G T L LA ++ G+ + M+ LL N H S
Sbjct: 635 NIVTKQGVTPLHLA--------------------SQEGHTD-MVTLLLDKGANIHMSTKS 673
Query: 211 KSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACV 270
T LHLAA ++V + +L +HGAD A K PL AC YG+ ++ L+K GA V
Sbjct: 674 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 733
Query: 271 NAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLA 317
NA +TPLH+AA + + ++LL +GA P + +A+ +A
Sbjct: 734 NAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 780
Score = 130 bits (328), Expect = 6e-30
Identities = 128/440 (29%), Positives = 178/440 (40%), Gaps = 90/440 (20%)
Query: 436 SLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN-----VQQLLQEGISLGNS 490
S RAA G+L L G D N + G AL + + VQ+LL G S+ ++
Sbjct: 13 SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 72
Query: 491 --EADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQH 548
+ + L A+ AG E VK L + N TPL+ AA N + VV+YLL++
Sbjct: 73 TKKGNTALHIASLAGQAEVVKVL-VKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 131
Query: 549 GADVHAKDKGGLVPLHNACSYGHYEVAELLVK---------------------------- 580
GA+ + G PL A GH + +L++
Sbjct: 132 GANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLL 191
Query: 581 ---HGA------VVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDL 631
H A +VN FTPLH AA G + LLL GA R+G TPL +
Sbjct: 192 QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHV 251
Query: 632 V-KDGDTDIQDLLRGDAALLD------------AAKKG--------------CLARVKKL 664
K G+T++ LL +D AA+ G LAR K
Sbjct: 252 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 311
Query: 665 SSP-------DNVNCRDTQGRHSTP-----------LHLAAGYNNLEVAEYLLQHGADVN 706
SP D+V C +H P LH+AA + V + LL A+ N
Sbjct: 312 LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPN 371
Query: 707 AQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLA 766
A+ G PLH A + V LL+KY A + A + TP+H AA G + LLL
Sbjct: 372 ARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQ 431
Query: 767 HGADPTLKNQEGQTPLDLVS 786
+GA P + N G+T L + +
Sbjct: 432 NGASPDVTNIRGETALHMAA 451
Score = 95.5 bits (236), Expect = 3e-19
Identities = 75/257 (29%), Positives = 104/257 (40%), Gaps = 54/257 (21%)
Query: 16 AAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVE 75
AAA++ + D ++V L+ + + TA TPLH AA + +
Sbjct: 566 AAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAS 625
Query: 76 YLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKG 135
LL GA G+ PLH A GH ++V LLL GA+ + T LH AA +
Sbjct: 626 TLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 685
Query: 136 KIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMA 195
K++V +L +HGA+ D T L
Sbjct: 686 KVNVADILTKHGAD-----QDAHTKLG--------------------------------- 707
Query: 196 LLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYG 255
TPL V CH Y VK+V LL+ GA+V+AK K PLH A G
Sbjct: 708 -YTPLIVACH---------------YGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQG 751
Query: 256 HYEVTELLVKHGACVNA 272
H + +L++HGA NA
Sbjct: 752 HTHIINVLLQHGAKPNA 768
Score = 66.2 bits (160), Expect = 2e-10
Identities = 48/139 (34%), Positives = 62/139 (44%), Gaps = 15/139 (10%)
Query: 60 TPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNA 119
TPL A +G +V +LL+ GANV A+ G PLH A GH ++N+LL+HGA PNA
Sbjct: 709 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 768
Query: 120 RDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNT------------DGRTALDLADPS 167
T L A G I V L E T T LD++D
Sbjct: 769 TTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEE 828
Query: 168 AKAVLT---GEYKKDELLE 183
+T GEY + E L+
Sbjct: 829 GDDTMTGDGGEYLRPEDLK 847
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 308 bits (788), Expect = 3e-83
Identities = 265/817 (32%), Positives = 372/817 (45%), Gaps = 121/817 (14%)
Query: 31 ACRNGDVERV-KRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDD 89
A R G++++V + L +N+ + G + LH AA G +V+ LL G++V +
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNA--LHLAAKEGHVGLVQELLGRGSSVDSATK 95
Query: 90 GGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAE 149
G LH A G AEVV +L++ GA+ NA+ +TPL+ AA + IDV LL++GA
Sbjct: 96 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155
Query: 150 PTIRNTDGRTALDLA----DPSAKAVLTGEYKKDEL----LESARSGNEEKMMALLTPLN 201
+ DG T L +A A A+L K ++ L A ++ K ALL
Sbjct: 156 QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ-- 213
Query: 202 VNCHASDGRKS-----------TPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHN 250
N H +D + TPLH+AA Y V + LLL GA V + + PLH
Sbjct: 214 -NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHV 272
Query: 251 ACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHN 310
A G+ + +LL+ G ++A TPLH AA +V LLL GA P L N
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-PLLARTKN 331
Query: 311 KSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQT-----HE 365
G S L A + D KHL + K P +
Sbjct: 332 ---------------------GLSPLHMAAQGDHVECVKHL----LQHKAPVDDVTLDYL 366
Query: 366 TALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAK 425
TALH AA + + + +LLL K AN N + TPLH+A +K V+E++VK+ A
Sbjct: 367 TALHVAAHCGHYR---VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 423
Query: 426 VNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGN-----ENVQQL 480
+ A+ G T +H AA+ GHL LLL G P++ +++G TAL M E V+ L
Sbjct: 424 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
Query: 481 LQEGISLGNSEADRQ--LLEAAKAGDVETVKKL---------CTVQSVNCRDIEGRQS-- 527
L+ G + + Q L A++ G E V+ L T I R+
Sbjct: 484 LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQV 543
Query: 528 ---------------------TPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNA 566
TPLH AA Y + V + LLQ A + K GL PLH A
Sbjct: 544 DVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 603
Query: 567 CSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGN 626
Y + +VA LL++ GA + +TPLH AA K + +I LL +GA+ + G
Sbjct: 604 AHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV 663
Query: 627 TPLDLV-KDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHL 685
TPL L ++G TD+ LL A + + K L T LHL
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL----------------------TSLHL 701
Query: 686 AAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWA 745
AA + + VA+ L +HGAD +A K G PL A YG+V + L+K A VNA K
Sbjct: 702 AAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNG 761
Query: 746 FTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPL 782
+TPLH+AAQ+G T + +LL HGA P G T L
Sbjct: 762 YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 798
Score = 261 bits (666), Expect = 4e-69
Identities = 215/665 (32%), Positives = 324/665 (48%), Gaps = 58/665 (8%)
Query: 182 LESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAK 240
L +AR+GN +K++ L +++N +G + LHLAA V +VQ LL G+ V +
Sbjct: 36 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNA--LHLAAKEGHVGLVQELLGRGSSVDSA 93
Query: 241 DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG 300
K LH A G EV ++LVK GA +NA FTPL+ AA +N ++V LL G
Sbjct: 94 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153
Query: 301 ADPT-------------LLNCHNKSAIDLA----------PTPQLKERLAYEFKGHSLLQ 337
A+ + L HN++ L P + R LLQ
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213
Query: 338 AAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKT 397
ADV S MVN + ++ T LH AA + + LLL +GA ++
Sbjct: 214 NDHNADVQ------SKMMVN-RTTESGFTPLHIAA---HYGNVNVATLLLNRGAAVDFTA 263
Query: 398 KEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGC 457
+ +TPLHVAS++ + ++V++++ +++A G T LH AA GH Q LLL G
Sbjct: 264 RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA 323
Query: 458 DPNIISLQGFTALQMGNEN-----VQQLLQEGISLGNSEAD--RQLLEAAKAGDVETVKK 510
+ G + L M + V+ LLQ + + D L AA G K
Sbjct: 324 PLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKL 383
Query: 511 LCTVQS-VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSY 569
L ++ N R + G TPLH A NR+ V+E L+++GA + A + GL P+H A
Sbjct: 384 LLDKRANPNARALNG--FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 441
Query: 570 GHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPL 629
GH + LL+++GA +V ++ T LH AA G+ E+ + LL++GA + R+ TPL
Sbjct: 442 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPL 501
Query: 630 DLVKD-GDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCR----DTQGRHS---- 680
+ G T+I LL A DAA + + V+ + HS
Sbjct: 502 HIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK 561
Query: 681 ---TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNAC 737
TPLH+AA Y +L+VA+ LLQ A ++ K GL PLH AA Y + VA LL++ A
Sbjct: 562 KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS 621
Query: 738 VNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAA 797
+AT K +TPLH AA+K + Q+ + LL +GA+ + ++G TPL L S + + ++T
Sbjct: 622 PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Query: 798 MPPSA 802
+ A
Sbjct: 682 LDKGA 686
Score = 248 bits (634), Expect = 2e-65
Identities = 226/743 (30%), Positives = 331/743 (44%), Gaps = 125/743 (16%)
Query: 98 ACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDG 157
A G+ + V L+ G D N + LH AA +G + + LL G+ G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 158 RTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHL 217
TAL +A + +A E K + E A N+N + +G TPL++
Sbjct: 98 NTALHIASLAGQA----EVVKVLVKEGA---------------NINAQSQNG--FTPLYM 136
Query: 218 AAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK------------ 265
AA N + +V+ LL++GA+ + PL A GH + +L++
Sbjct: 137 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPAL 196
Query: 266 -------------------HGA------CVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG 300
H A VN FTPLH AA V V +LLL+ G
Sbjct: 197 HIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRG 256
Query: 301 ADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKH 360
A A+D G + L A + T + K L L+
Sbjct: 257 A-----------AVDFTAR-----------NGITPLHVASKRGNTNMVK-LLLDRGGQID 293
Query: 361 PQTHE--TALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEV 418
+T + T LHCAA S + Q+ ELLL +GA + +TK L+PLH+A++ H + V+
Sbjct: 294 AKTRDGLTPLHCAARSGHD---QVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 350
Query: 419 VVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQ 478
+++H+A V+ + T+LH AA+CGH + +LLL +PN +L GFT L +
Sbjct: 351 LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHI------ 404
Query: 479 QLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNR 538
A K ++ V +L + + I TP+H AA
Sbjct: 405 --------------------ACKKNRIK-VMELLVKYGASIQAITESGLTPIHVAAFMGH 443
Query: 539 VSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHE 598
+++V LLQ+GA + G LH A G EV L+++GA+V+ + TPLH
Sbjct: 444 LNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHI 503
Query: 599 AAAKGKYEICKLLLQHGADPTKKNRDGNTPLDL-VKDGDTDIQD-LLRGDAALLDAAKKG 656
A+ GK EI +LLLQH A P +G TPL + ++G D+ LL AA A KKG
Sbjct: 504 ASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKG 563
Query: 657 C--LARVKKLSSPDNVN-------CRDTQGRHS-TPLHLAAGYNNLEVAEYLLQHGADVN 706
L K S D D+ G++ TPLH+AA Y+N +VA LL+ GA +
Sbjct: 564 FTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH 623
Query: 707 AQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLA 766
A K G PLH AA + +A+ L+ Y A N K TPLH A+Q+G T + LLL
Sbjct: 624 ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 683
Query: 767 HGADPTLKNQEGQTPLDLVSADD 789
GA+ + + G T L L + +D
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQED 706
Score = 229 bits (585), Expect = 9e-60
Identities = 184/597 (30%), Positives = 278/597 (46%), Gaps = 52/597 (8%)
Query: 60 TPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNA 119
TPLH AA +G +V LL GA V G+ PLH A G+ +V LLL G +A
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 120 RDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKK- 178
+ TPLH AA G V +LL+ GA R +G + L +A G++ +
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA-------AQGDHVEC 347
Query: 179 -DELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADV 237
LL+ ++ + L T LH+AA ++ +LLL A+
Sbjct: 348 VKHLLQHKAPVDDVTLDYL----------------TALHVAAHCGHYRVTKLLLDKRANP 391
Query: 238 HAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLL 297
+A+ PLH AC +V ELLVK+GA + A+ TP+H AA + + LLL
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLL 451
Query: 298 SYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQA-AREADV-----TRIKKH- 350
GA P + N ++A+ +A E + + +L+ A ARE +R+ K
Sbjct: 452 QNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTE 511
Query: 351 -LSLEMVNFKHPQTHET----ALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLH 405
+ L + + HP T LH +A + + +LL GA + TK+ TPLH
Sbjct: 512 IVQLLLQHMAHPDAATTNGYTPLHISAREG---QVDVASVLLEAGAAHSLATKKGFTPLH 568
Query: 406 VASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQ 465
VA++ DV +++++ A ++ G T LH AA+ + + LLL G P+ +
Sbjct: 569 VAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN 628
Query: 466 GFTALQMGNENVQQLLQEGISLGNSEADRQLLE---------AAKAGDVETVKKLCTVQS 516
G+T L + + Q +Q +L N A+ ++ A++ G + V L +
Sbjct: 629 GYTPLHIAAKKNQ--MQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD-KG 685
Query: 517 VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAE 576
N T LH AA ++V+V + L +HGAD A K G PL AC YG+ ++
Sbjct: 686 ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVN 745
Query: 577 LLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVK 633
L+K GA VN +TPLH+AA +G I +LLQHGA P +GNT L + K
Sbjct: 746 FLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802
Score = 181 bits (458), Expect = 5e-45
Identities = 141/480 (29%), Positives = 224/480 (46%), Gaps = 32/480 (6%)
Query: 39 RVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNA 98
RV +L+ ++ N A TPLH A R V+E L++ GA++QA + GL P+H A
Sbjct: 379 RVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 438
Query: 99 CSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGR 158
GH +V LLL++GA P+ + T LH AA G+++V LL++GA R + +
Sbjct: 439 AFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQ 498
Query: 159 TALDLADPSAK---------------AVLTGEYKKDELLESARSGNEEKMMALLTPLNVN 203
T L +A K A T Y + SAR G + LL +
Sbjct: 499 TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHI--SAREGQVDVASVLLEAGAAH 556
Query: 204 CHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELL 263
A+ + TPLH+AA Y + + +LLLQ A + K L PLH A Y + +V LL
Sbjct: 557 SLATK-KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615
Query: 264 VKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLK 323
++ GA +A +TPLH AA KN++++ S LL+YGA+ ++ + + LA
Sbjct: 616 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 675
Query: 324 ERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCA----------AA 373
+ + + + + ++ +T + + VN T A A A
Sbjct: 676 DMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVA 735
Query: 374 SPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLG 433
Y K + LL++GAN+N KTK TPLH A+++ H ++ V+++H AK NA G
Sbjct: 736 CHYGNVKMV-NFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANG 794
Query: 434 QTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEAD 493
T+L A G++ L ++ T + NV + + E + + + E D
Sbjct: 795 NTALAIAKRLGYISVVDTLKVV---TEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGD 851
Score = 150 bits (378), Expect = 9e-36
Identities = 99/287 (34%), Positives = 140/287 (48%), Gaps = 22/287 (7%)
Query: 31 ACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDG 90
+ R G V+ L+ +S T + TPLH AA +G DV + LLQ A +
Sbjct: 537 SAREGQVDVASVLLEAGAAHSLATK-KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN 595
Query: 91 GLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEP 150
GL PLH A + + +V LLL GA P+A YTPLH AA K ++ + LL +GAE
Sbjct: 596 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 655
Query: 151 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGR 210
I G T L LA ++ G+ + M+ LL N H S
Sbjct: 656 NIVTKQGVTPLHLA--------------------SQEGHTD-MVTLLLDKGANIHMSTKS 694
Query: 211 KSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACV 270
T LHLAA ++V + +L +HGAD A K PL AC YG+ ++ L+K GA V
Sbjct: 695 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 754
Query: 271 NAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLA 317
NA +TPLH+AA + + ++LL +GA P + +A+ +A
Sbjct: 755 NAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 801
Score = 130 bits (328), Expect = 6e-30
Identities = 128/440 (29%), Positives = 178/440 (40%), Gaps = 90/440 (20%)
Query: 436 SLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN-----VQQLLQEGISLGNS 490
S RAA G+L L G D N + G AL + + VQ+LL G S+ ++
Sbjct: 34 SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93
Query: 491 --EADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQH 548
+ + L A+ AG E VK L + N TPL+ AA N + VV+YLL++
Sbjct: 94 TKKGNTALHIASLAGQAEVVKVL-VKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 152
Query: 549 GADVHAKDKGGLVPLHNACSYGHYEVAELLVK---------------------------- 580
GA+ + G PL A GH + +L++
Sbjct: 153 GANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLL 212
Query: 581 ---HGA------VVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDL 631
H A +VN FTPLH AA G + LLL GA R+G TPL +
Sbjct: 213 QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHV 272
Query: 632 V-KDGDTDIQDLLRGDAALLD------------AAKKG--------------CLARVKKL 664
K G+T++ LL +D AA+ G LAR K
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 332
Query: 665 SSP-------DNVNCRDTQGRHSTP-----------LHLAAGYNNLEVAEYLLQHGADVN 706
SP D+V C +H P LH+AA + V + LL A+ N
Sbjct: 333 LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPN 392
Query: 707 AQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLA 766
A+ G PLH A + V LL+KY A + A + TP+H AA G + LLL
Sbjct: 393 ARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQ 452
Query: 767 HGADPTLKNQEGQTPLDLVS 786
+GA P + N G+T L + +
Sbjct: 453 NGASPDVTNIRGETALHMAA 472
Score = 95.5 bits (236), Expect = 3e-19
Identities = 75/257 (29%), Positives = 104/257 (40%), Gaps = 54/257 (21%)
Query: 16 AAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVE 75
AAA++ + D ++V L+ + + TA TPLH AA + +
Sbjct: 587 AAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAS 646
Query: 76 YLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKG 135
LL GA G+ PLH A GH ++V LLL GA+ + T LH AA +
Sbjct: 647 TLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 706
Query: 136 KIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMA 195
K++V +L +HGA+ D T L
Sbjct: 707 KVNVADILTKHGAD-----QDAHTKLG--------------------------------- 728
Query: 196 LLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYG 255
TPL V CH Y VK+V LL+ GA+V+AK K PLH A G
Sbjct: 729 -YTPLIVACH---------------YGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQG 772
Query: 256 HYEVTELLVKHGACVNA 272
H + +L++HGA NA
Sbjct: 773 HTHIINVLLQHGAKPNA 789
Score = 66.2 bits (160), Expect = 2e-10
Identities = 48/139 (34%), Positives = 62/139 (44%), Gaps = 15/139 (10%)
Query: 60 TPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNA 119
TPL A +G +V +LL+ GANV A+ G PLH A GH ++N+LL+HGA PNA
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789
Query: 120 RDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNT------------DGRTALDLADPS 167
T L A G I V L E T T LD++D
Sbjct: 790 TTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEE 849
Query: 168 AKAVLT---GEYKKDELLE 183
+T GEY + E L+
Sbjct: 850 GDDTMTGDGGEYLRPEDLK 868
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 308 bits (788), Expect = 3e-83
Identities = 265/817 (32%), Positives = 372/817 (45%), Gaps = 121/817 (14%)
Query: 31 ACRNGDVERV-KRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDD 89
A R G++++V + L +N+ + G + LH AA G +V+ LL G++V +
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNA--LHLAAKEGHVGLVQELLGRGSSVDSATK 95
Query: 90 GGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAE 149
G LH A G AEVV +L++ GA+ NA+ +TPL+ AA + IDV LL++GA
Sbjct: 96 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155
Query: 150 PTIRNTDGRTALDLA----DPSAKAVLTGEYKKDEL----LESARSGNEEKMMALLTPLN 201
+ DG T L +A A A+L K ++ L A ++ K ALL
Sbjct: 156 QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ-- 213
Query: 202 VNCHASDGRKS-----------TPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHN 250
N H +D + TPLH+AA Y V + LLL GA V + + PLH
Sbjct: 214 -NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHV 272
Query: 251 ACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHN 310
A G+ + +LL+ G ++A TPLH AA +V LLL GA P L N
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-PLLARTKN 331
Query: 311 KSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQT-----HE 365
G S L A + D KHL + K P +
Sbjct: 332 ---------------------GLSPLHMAAQGDHVECVKHL----LQHKAPVDDVTLDYL 366
Query: 366 TALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAK 425
TALH AA + + + +LLL K AN N + TPLH+A +K V+E++VK+ A
Sbjct: 367 TALHVAAHCGHYR---VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 423
Query: 426 VNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGN-----ENVQQL 480
+ A+ G T +H AA+ GHL LLL G P++ +++G TAL M E V+ L
Sbjct: 424 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
Query: 481 LQEGISLGNSEADRQ--LLEAAKAGDVETVKKL---------CTVQSVNCRDIEGRQS-- 527
L+ G + + Q L A++ G E V+ L T I R+
Sbjct: 484 LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQV 543
Query: 528 ---------------------TPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNA 566
TPLH AA Y + V + LLQ A + K GL PLH A
Sbjct: 544 DVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 603
Query: 567 CSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGN 626
Y + +VA LL++ GA + +TPLH AA K + +I LL +GA+ + G
Sbjct: 604 AHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV 663
Query: 627 TPLDLV-KDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHL 685
TPL L ++G TD+ LL A + + K L T LHL
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL----------------------TSLHL 701
Query: 686 AAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWA 745
AA + + VA+ L +HGAD +A K G PL A YG+V + L+K A VNA K
Sbjct: 702 AAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNG 761
Query: 746 FTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPL 782
+TPLH+AAQ+G T + +LL HGA P G T L
Sbjct: 762 YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 798
Score = 261 bits (666), Expect = 4e-69
Identities = 215/665 (32%), Positives = 324/665 (48%), Gaps = 58/665 (8%)
Query: 182 LESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAK 240
L +AR+GN +K++ L +++N +G + LHLAA V +VQ LL G+ V +
Sbjct: 36 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNA--LHLAAKEGHVGLVQELLGRGSSVDSA 93
Query: 241 DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG 300
K LH A G EV ++LVK GA +NA FTPL+ AA +N ++V LL G
Sbjct: 94 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153
Query: 301 ADPT-------------LLNCHNKSAIDLA----------PTPQLKERLAYEFKGHSLLQ 337
A+ + L HN++ L P + R LLQ
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213
Query: 338 AAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKT 397
ADV S MVN + ++ T LH AA + + LLL +GA ++
Sbjct: 214 NDHNADVQ------SKMMVN-RTTESGFTPLHIAA---HYGNVNVATLLLNRGAAVDFTA 263
Query: 398 KEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGC 457
+ +TPLHVAS++ + ++V++++ +++A G T LH AA GH Q LLL G
Sbjct: 264 RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA 323
Query: 458 DPNIISLQGFTALQMGNEN-----VQQLLQEGISLGNSEAD--RQLLEAAKAGDVETVKK 510
+ G + L M + V+ LLQ + + D L AA G K
Sbjct: 324 PLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKL 383
Query: 511 LCTVQS-VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSY 569
L ++ N R + G TPLH A NR+ V+E L+++GA + A + GL P+H A
Sbjct: 384 LLDKRANPNARALNG--FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 441
Query: 570 GHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPL 629
GH + LL+++GA +V ++ T LH AA G+ E+ + LL++GA + R+ TPL
Sbjct: 442 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPL 501
Query: 630 DLVKD-GDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCR----DTQGRHS---- 680
+ G T+I LL A DAA + + V+ + HS
Sbjct: 502 HIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK 561
Query: 681 ---TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNAC 737
TPLH+AA Y +L+VA+ LLQ A ++ K GL PLH AA Y + VA LL++ A
Sbjct: 562 KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS 621
Query: 738 VNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAA 797
+AT K +TPLH AA+K + Q+ + LL +GA+ + ++G TPL L S + + ++T
Sbjct: 622 PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Query: 798 MPPSA 802
+ A
Sbjct: 682 LDKGA 686
Score = 248 bits (634), Expect = 2e-65
Identities = 226/743 (30%), Positives = 331/743 (44%), Gaps = 125/743 (16%)
Query: 98 ACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDG 157
A G+ + V L+ G D N + LH AA +G + + LL G+ G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 158 RTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHL 217
TAL +A + +A E K + E A N+N + +G TPL++
Sbjct: 98 NTALHIASLAGQA----EVVKVLVKEGA---------------NINAQSQNG--FTPLYM 136
Query: 218 AAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK------------ 265
AA N + +V+ LL++GA+ + PL A GH + +L++
Sbjct: 137 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPAL 196
Query: 266 -------------------HGA------CVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG 300
H A VN FTPLH AA V V +LLL+ G
Sbjct: 197 HIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRG 256
Query: 301 ADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKH 360
A A+D G + L A + T + K L L+
Sbjct: 257 A-----------AVDFTAR-----------NGITPLHVASKRGNTNMVK-LLLDRGGQID 293
Query: 361 PQTHE--TALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEV 418
+T + T LHCAA S + Q+ ELLL +GA + +TK L+PLH+A++ H + V+
Sbjct: 294 AKTRDGLTPLHCAARSGHD---QVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 350
Query: 419 VVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQ 478
+++H+A V+ + T+LH AA+CGH + +LLL +PN +L GFT L +
Sbjct: 351 LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHI------ 404
Query: 479 QLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNR 538
A K ++ V +L + + I TP+H AA
Sbjct: 405 --------------------ACKKNRIK-VMELLVKYGASIQAITESGLTPIHVAAFMGH 443
Query: 539 VSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHE 598
+++V LLQ+GA + G LH A G EV L+++GA+V+ + TPLH
Sbjct: 444 LNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHI 503
Query: 599 AAAKGKYEICKLLLQHGADPTKKNRDGNTPLDL-VKDGDTDIQD-LLRGDAALLDAAKKG 656
A+ GK EI +LLLQH A P +G TPL + ++G D+ LL AA A KKG
Sbjct: 504 ASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKG 563
Query: 657 C--LARVKKLSSPDNVN-------CRDTQGRHS-TPLHLAAGYNNLEVAEYLLQHGADVN 706
L K S D D+ G++ TPLH+AA Y+N +VA LL+ GA +
Sbjct: 564 FTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH 623
Query: 707 AQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLA 766
A K G PLH AA + +A+ L+ Y A N K TPLH A+Q+G T + LLL
Sbjct: 624 ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 683
Query: 767 HGADPTLKNQEGQTPLDLVSADD 789
GA+ + + G T L L + +D
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQED 706
Score = 229 bits (585), Expect = 9e-60
Identities = 184/597 (30%), Positives = 278/597 (46%), Gaps = 52/597 (8%)
Query: 60 TPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNA 119
TPLH AA +G +V LL GA V G+ PLH A G+ +V LLL G +A
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 120 RDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKK- 178
+ TPLH AA G V +LL+ GA R +G + L +A G++ +
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA-------AQGDHVEC 347
Query: 179 -DELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADV 237
LL+ ++ + L T LH+AA ++ +LLL A+
Sbjct: 348 VKHLLQHKAPVDDVTLDYL----------------TALHVAAHCGHYRVTKLLLDKRANP 391
Query: 238 HAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLL 297
+A+ PLH AC +V ELLVK+GA + A+ TP+H AA + + LLL
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLL 451
Query: 298 SYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQA-AREADV-----TRIKKH- 350
GA P + N ++A+ +A E + + +L+ A ARE +R+ K
Sbjct: 452 QNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTE 511
Query: 351 -LSLEMVNFKHPQTHET----ALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLH 405
+ L + + HP T LH +A + + +LL GA + TK+ TPLH
Sbjct: 512 IVQLLLQHMAHPDAATTNGYTPLHISAREG---QVDVASVLLEAGAAHSLATKKGFTPLH 568
Query: 406 VASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQ 465
VA++ DV +++++ A ++ G T LH AA+ + + LLL G P+ +
Sbjct: 569 VAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN 628
Query: 466 GFTALQMGNENVQQLLQEGISLGNSEADRQLLE---------AAKAGDVETVKKLCTVQS 516
G+T L + + Q +Q +L N A+ ++ A++ G + V L +
Sbjct: 629 GYTPLHIAAKKNQ--MQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD-KG 685
Query: 517 VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAE 576
N T LH AA ++V+V + L +HGAD A K G PL AC YG+ ++
Sbjct: 686 ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVN 745
Query: 577 LLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVK 633
L+K GA VN +TPLH+AA +G I +LLQHGA P +GNT L + K
Sbjct: 746 FLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802
Score = 181 bits (458), Expect = 5e-45
Identities = 141/480 (29%), Positives = 224/480 (46%), Gaps = 32/480 (6%)
Query: 39 RVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNA 98
RV +L+ ++ N A TPLH A R V+E L++ GA++QA + GL P+H A
Sbjct: 379 RVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 438
Query: 99 CSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGR 158
GH +V LLL++GA P+ + T LH AA G+++V LL++GA R + +
Sbjct: 439 AFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQ 498
Query: 159 TALDLADPSAK---------------AVLTGEYKKDELLESARSGNEEKMMALLTPLNVN 203
T L +A K A T Y + SAR G + LL +
Sbjct: 499 TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHI--SAREGQVDVASVLLEAGAAH 556
Query: 204 CHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELL 263
A+ + TPLH+AA Y + + +LLLQ A + K L PLH A Y + +V LL
Sbjct: 557 SLATK-KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615
Query: 264 VKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLK 323
++ GA +A +TPLH AA KN++++ S LL+YGA+ ++ + + LA
Sbjct: 616 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 675
Query: 324 ERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCA----------AA 373
+ + + + + ++ +T + + VN T A A A
Sbjct: 676 DMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVA 735
Query: 374 SPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLG 433
Y K + LL++GAN+N KTK TPLH A+++ H ++ V+++H AK NA G
Sbjct: 736 CHYGNVKMV-NFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANG 794
Query: 434 QTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEAD 493
T+L A G++ L ++ T + NV + + E + + + E D
Sbjct: 795 NTALAIAKRLGYISVVDTLKVV---TEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGD 851
Score = 150 bits (378), Expect = 9e-36
Identities = 99/287 (34%), Positives = 140/287 (48%), Gaps = 22/287 (7%)
Query: 31 ACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDG 90
+ R G V+ L+ +S T + TPLH AA +G DV + LLQ A +
Sbjct: 537 SAREGQVDVASVLLEAGAAHSLATK-KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN 595
Query: 91 GLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEP 150
GL PLH A + + +V LLL GA P+A YTPLH AA K ++ + LL +GAE
Sbjct: 596 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 655
Query: 151 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGR 210
I G T L LA ++ G+ + M+ LL N H S
Sbjct: 656 NIVTKQGVTPLHLA--------------------SQEGHTD-MVTLLLDKGANIHMSTKS 694
Query: 211 KSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACV 270
T LHLAA ++V + +L +HGAD A K PL AC YG+ ++ L+K GA V
Sbjct: 695 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 754
Query: 271 NAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLA 317
NA +TPLH+AA + + ++LL +GA P + +A+ +A
Sbjct: 755 NAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 801
Score = 130 bits (328), Expect = 6e-30
Identities = 128/440 (29%), Positives = 178/440 (40%), Gaps = 90/440 (20%)
Query: 436 SLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN-----VQQLLQEGISLGNS 490
S RAA G+L L G D N + G AL + + VQ+LL G S+ ++
Sbjct: 34 SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93
Query: 491 --EADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQH 548
+ + L A+ AG E VK L + N TPL+ AA N + VV+YLL++
Sbjct: 94 TKKGNTALHIASLAGQAEVVKVL-VKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 152
Query: 549 GADVHAKDKGGLVPLHNACSYGHYEVAELLVK---------------------------- 580
GA+ + G PL A GH + +L++
Sbjct: 153 GANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLL 212
Query: 581 ---HGA------VVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDL 631
H A +VN FTPLH AA G + LLL GA R+G TPL +
Sbjct: 213 QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHV 272
Query: 632 V-KDGDTDIQDLLRGDAALLD------------AAKKG--------------CLARVKKL 664
K G+T++ LL +D AA+ G LAR K
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 332
Query: 665 SSP-------DNVNCRDTQGRHSTP-----------LHLAAGYNNLEVAEYLLQHGADVN 706
SP D+V C +H P LH+AA + V + LL A+ N
Sbjct: 333 LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPN 392
Query: 707 AQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLA 766
A+ G PLH A + V LL+KY A + A + TP+H AA G + LLL
Sbjct: 393 ARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQ 452
Query: 767 HGADPTLKNQEGQTPLDLVS 786
+GA P + N G+T L + +
Sbjct: 453 NGASPDVTNIRGETALHMAA 472
Score = 95.5 bits (236), Expect = 3e-19
Identities = 75/257 (29%), Positives = 104/257 (40%), Gaps = 54/257 (21%)
Query: 16 AAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVE 75
AAA++ + D ++V L+ + + TA TPLH AA + +
Sbjct: 587 AAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAS 646
Query: 76 YLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKG 135
LL GA G+ PLH A GH ++V LLL GA+ + T LH AA +
Sbjct: 647 TLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 706
Query: 136 KIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMA 195
K++V +L +HGA+ D T L
Sbjct: 707 KVNVADILTKHGAD-----QDAHTKLG--------------------------------- 728
Query: 196 LLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYG 255
TPL V CH Y VK+V LL+ GA+V+AK K PLH A G
Sbjct: 729 -YTPLIVACH---------------YGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQG 772
Query: 256 HYEVTELLVKHGACVNA 272
H + +L++HGA NA
Sbjct: 773 HTHIINVLLQHGAKPNA 789
Score = 66.2 bits (160), Expect = 2e-10
Identities = 48/139 (34%), Positives = 62/139 (44%), Gaps = 15/139 (10%)
Query: 60 TPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNA 119
TPL A +G +V +LL+ GANV A+ G PLH A GH ++N+LL+HGA PNA
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789
Query: 120 RDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNT------------DGRTALDLADPS 167
T L A G I V L E T T LD++D
Sbjct: 790 TTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEE 849
Query: 168 AKAVLT---GEYKKDELLE 183
+T GEY + E L+
Sbjct: 850 GDDTMTGDGGEYLRPEDLK 868
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 303 bits (775), Expect = 8e-82
Identities = 253/808 (31%), Positives = 373/808 (46%), Gaps = 65/808 (8%)
Query: 24 AARELFEACRNGDVER-VKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGA 82
AA A R+G++++ + L +N+ + G LH A+ G +V LL
Sbjct: 45 AATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELLHKEI 102
Query: 83 NVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIV 142
++ G LH A G EVV L+ +GA+ NA+ +TPL+ AA + ++V
Sbjct: 103 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 162
Query: 143 LLQHGAEPTIRNTDGRTALDLA------DPSAKAVLTGEYKKDEL--LESARSGNEEKMM 194
LL++GA + DG T L +A + A + G K L L A ++ +
Sbjct: 163 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 222
Query: 195 ALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSY 254
A+L + N TPLH+AA Y + + QLLL GA V+ + + PLH A
Sbjct: 223 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 282
Query: 255 GHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAI 314
G+ + LL+ GA + + TPLH AA V + +LL +GA + S I
Sbjct: 283 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 342
Query: 315 DLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAAS 374
+A + + LLQ E D ++L+ H T LH AA
Sbjct: 343 HMAAQGDHLDCV------RLLLQYDAEID------DITLD---------HLTPLHVAA-- 379
Query: 375 PYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQ 434
+ ++ ++LL KGA N + TPLH+A +K H V+E+++K A ++A+ G
Sbjct: 380 -HCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 438
Query: 435 TSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMG-----NENVQQLLQEGISLGN 489
T LH A++ GHL + LL G PN+ +++ T L M E + LLQ +
Sbjct: 439 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 498
Query: 490 SEADRQ--LLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQ 547
D Q L AA+ G V KL + N TPLH AA V V LL+
Sbjct: 499 KAKDDQTPLHCAARIGHTNMV-KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE 557
Query: 548 HGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEI 607
A K G PLH A YG VAELL++ A N A TPLH A +I
Sbjct: 558 KEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDI 617
Query: 608 CKLLLQHGADPTKKNRDGNTPL-------------DLVKDGDTDIQDLLRGDAALLDAAK 654
KLLL G P +G TPL L++ G + + ++G L AA+
Sbjct: 618 VKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQ 677
Query: 655 KGCLARVK-KLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGL 713
+G V LS N N + G TPLHL A ++ VA+ L++HG V+A + G
Sbjct: 678 EGHAEMVALLLSKQANGNLGNKSG--LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 735
Query: 714 IPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTL 773
PLH A+ YG++ + L+++ A VNA K ++PLH+AAQ+G T + LLL +GA P
Sbjct: 736 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 795
Query: 774 KNQEGQTPLDL------VSADDVSALLT 795
+ +G TPL + +S DV ++T
Sbjct: 796 VSSDGTTPLAIAKRLGYISVTDVLKVVT 823
Score = 297 bits (761), Expect = 3e-80
Identities = 252/804 (31%), Positives = 353/804 (43%), Gaps = 89/804 (11%)
Query: 31 ACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDG 90
A + G V+ V L+ E + T + +T LH AA G+ +VV L+ GANV A+
Sbjct: 85 ASKEGHVKMVVELLHKEII-LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 143
Query: 91 GLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEP 150
G PL+ A H EVV LL +GA+ N +TPL A +G +V L+ +G
Sbjct: 144 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG--- 200
Query: 151 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGR 210
T G+ L L A ++ + A+L + N
Sbjct: 201 ----TKGKVRLPA------------------LHIAARNDDTRTAAVLLQNDPNPDVLSKT 238
Query: 211 KSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACV 270
TPLH+AA Y + + QLLL GA V+ + + PLH A G+ + LL+ GA +
Sbjct: 239 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 298
Query: 271 NAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEF 330
+ TPLH AA V + +LL +GA + S I +A + +
Sbjct: 299 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL-- 356
Query: 331 KGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKG 390
LLQ E D ++L+ H T LH AA + + + ++LL KG
Sbjct: 357 ----LLQYDAEID------DITLD---------HLTPLHVAAHCGHHR---VAKVLLDKG 394
Query: 391 ANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCR 450
A N + TPLH+A +K H V+E+++K A ++A+ G T LH A++ GHL +
Sbjct: 395 AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVK 454
Query: 451 LLLSYGCDPNIISLQGFTALQMG-----NENVQQLLQEGISLGNSEADRQ--LLEAAKAG 503
LL G PN+ +++ T L M E + LLQ + D Q L AA+ G
Sbjct: 455 NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 514
Query: 504 DVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPL 563
VK L + N TPLH AA V V LL+ A K G PL
Sbjct: 515 HTNMVKLLLE-NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 573
Query: 564 HNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNR 623
H A YG VAELL++ A N A TPLH A +I KLLL G P
Sbjct: 574 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 633
Query: 624 DGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSS-PDNVNCRDTQGRHSTP 682
+G TPL + AAK+ + + L + N QG TP
Sbjct: 634 NGYTPLHI--------------------AAKQNQVEVARSLLQYGGSANAESVQG--VTP 671
Query: 683 LHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATD 742
LHLAA + E+ LL A+ N +K GL PLH A GHV VA +LIK+ V+AT
Sbjct: 672 LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATT 731
Query: 743 KWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSA 802
+ +TPLH A+ G +L LL H AD K + G +PL + + ++T + A
Sbjct: 732 RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGA 791
Query: 803 LPSCYKPQVLNGVRSPGATADALS 826
P N V S G T A++
Sbjct: 792 SP--------NEVSSDGTTPLAIA 807
Score = 144 bits (363), Expect = 5e-34
Identities = 129/469 (27%), Positives = 194/469 (41%), Gaps = 59/469 (12%)
Query: 371 AAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALD 430
A A K K+ R + +K + T A+ + D +++ +N +
Sbjct: 16 AQALQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCN 75
Query: 431 NLGQTSLHRAAYCGHL---------------------------------QTCRLLLSYGC 457
G LH A+ GH+ + R L++YG
Sbjct: 76 QNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGA 135
Query: 458 DPNIISLQGFTALQMGN-----ENVQQLLQEGI--SLGNSEADRQLLEAAKAGDVETVKK 510
+ N S +GFT L M E V+ LL+ G ++ + L A + G V
Sbjct: 136 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 195
Query: 511 LCTVQSVNCRDIEGRQSTP-LHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSY 569
L + +G+ P LH AA + LLQ+ + K G PLH A Y
Sbjct: 196 LINYGT------KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHY 249
Query: 570 GHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPL 629
+ VA+LL+ GA VN TPLH A+ +G + +LLL GA K +D TPL
Sbjct: 250 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 309
Query: 630 D-LVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNC-----------RDTQG 677
++G I ++L A + A K L+ + + D+++C D
Sbjct: 310 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL 369
Query: 678 RHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNAC 737
H TPLH+AA + VA+ LL GA N++ G PLH A HV V LL+K A
Sbjct: 370 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 429
Query: 738 VNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVS 786
++A + TPLH A+ G + LL GA P + N + +TPL + +
Sbjct: 430 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 478
Score = 128 bits (321), Expect = 4e-29
Identities = 97/312 (31%), Positives = 147/312 (47%), Gaps = 17/312 (5%)
Query: 490 SEADRQLLEAAKAGDVET----VKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYL 545
++A L AA++G+++ ++ + + N + G LH A+ V +V L
Sbjct: 43 ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG-----LHLASKEGHVKMVVEL 97
Query: 546 LQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKY 605
L + K G LH A G EV LV +GA VN FTPL+ AA +
Sbjct: 98 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 157
Query: 606 EICKLLLQHGADPTKKNRDGNTPLDL-VKDGDTDIQDLL-----RGDAAL--LDAAKKGC 657
E+ K LL++GA+ DG TPL + ++ G ++ L +G L L A +
Sbjct: 158 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARND 217
Query: 658 LARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLH 717
R + ++ N TPLH+AA Y NL VA+ LL GA VN + G+ PLH
Sbjct: 218 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 277
Query: 718 NAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQE 777
A+ G+V + LL+ A + K TPLH AA+ G ++ +LL HGA K +
Sbjct: 278 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 337
Query: 778 GQTPLDLVSADD 789
G +P+ + + D
Sbjct: 338 GLSPIHMAAQGD 349
Score = 90.5 bits (223), Expect = 8e-18
Identities = 57/152 (37%), Positives = 84/152 (55%), Gaps = 6/152 (3%)
Query: 15 SAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKS--TPLHFAAGFGRKD 72
SA AE+V+ L A + G E V L++ + + G KS TPLH A G
Sbjct: 660 SANAESVQ-GVTPLHLAAQEGHAEMVALLLSKQ---ANGNLGNKSGLTPLHLVAQEGHVP 715
Query: 73 VVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAA 132
V + L+++G V A G PLH A +G+ ++V LL+H AD NA+ Y+PLH+AA
Sbjct: 716 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 775
Query: 133 IKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA 164
+G D+ +LL++GA P ++DG T L +A
Sbjct: 776 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 807
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 303 bits (775), Expect = 8e-82
Identities = 253/808 (31%), Positives = 373/808 (46%), Gaps = 65/808 (8%)
Query: 24 AARELFEACRNGDVER-VKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGA 82
AA A R+G++++ + L +N+ + G LH A+ G +V LL
Sbjct: 12 AATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELLHKEI 69
Query: 83 NVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIV 142
++ G LH A G EVV L+ +GA+ NA+ +TPL+ AA + ++V
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129
Query: 143 LLQHGAEPTIRNTDGRTALDLA------DPSAKAVLTGEYKKDEL--LESARSGNEEKMM 194
LL++GA + DG T L +A + A + G K L L A ++ +
Sbjct: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 189
Query: 195 ALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSY 254
A+L + N TPLH+AA Y + + QLLL GA V+ + + PLH A
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
Query: 255 GHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAI 314
G+ + LL+ GA + + TPLH AA V + +LL +GA + S I
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309
Query: 315 DLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAAS 374
+A + + LLQ E D ++L+ H T LH AA
Sbjct: 310 HMAAQGDHLDCV------RLLLQYDAEID------DITLD---------HLTPLHVAA-- 346
Query: 375 PYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQ 434
+ ++ ++LL KGA N + TPLH+A +K H V+E+++K A ++A+ G
Sbjct: 347 -HCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 405
Query: 435 TSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMG-----NENVQQLLQEGISLGN 489
T LH A++ GHL + LL G PN+ +++ T L M E + LLQ +
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465
Query: 490 SEADRQ--LLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQ 547
D Q L AA+ G V KL + N TPLH AA V V LL+
Sbjct: 466 KAKDDQTPLHCAARIGHTNMV-KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE 524
Query: 548 HGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEI 607
A K G PLH A YG VAELL++ A N A TPLH A +I
Sbjct: 525 KEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDI 584
Query: 608 CKLLLQHGADPTKKNRDGNTPL-------------DLVKDGDTDIQDLLRGDAALLDAAK 654
KLLL G P +G TPL L++ G + + ++G L AA+
Sbjct: 585 VKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQ 644
Query: 655 KGCLARVK-KLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGL 713
+G V LS N N + G TPLHL A ++ VA+ L++HG V+A + G
Sbjct: 645 EGHAEMVALLLSKQANGNLGNKSG--LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 702
Query: 714 IPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTL 773
PLH A+ YG++ + L+++ A VNA K ++PLH+AAQ+G T + LLL +GA P
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762
Query: 774 KNQEGQTPLDL------VSADDVSALLT 795
+ +G TPL + +S DV ++T
Sbjct: 763 VSSDGTTPLAIAKRLGYISVTDVLKVVT 790
Score = 297 bits (761), Expect = 3e-80
Identities = 252/804 (31%), Positives = 353/804 (43%), Gaps = 89/804 (11%)
Query: 31 ACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDG 90
A + G V+ V L+ E + T + +T LH AA G+ +VV L+ GANV A+
Sbjct: 52 ASKEGHVKMVVELLHKEII-LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 110
Query: 91 GLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEP 150
G PL+ A H EVV LL +GA+ N +TPL A +G +V L+ +G
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG--- 167
Query: 151 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGR 210
T G+ L L A ++ + A+L + N
Sbjct: 168 ----TKGKVRLPA------------------LHIAARNDDTRTAAVLLQNDPNPDVLSKT 205
Query: 211 KSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACV 270
TPLH+AA Y + + QLLL GA V+ + + PLH A G+ + LL+ GA +
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 271 NAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEF 330
+ TPLH AA V + +LL +GA + S I +A + +
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL-- 323
Query: 331 KGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKG 390
LLQ E D ++L+ H T LH AA + + + ++LL KG
Sbjct: 324 ----LLQYDAEID------DITLD---------HLTPLHVAAHCGHHR---VAKVLLDKG 361
Query: 391 ANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCR 450
A N + TPLH+A +K H V+E+++K A ++A+ G T LH A++ GHL +
Sbjct: 362 AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVK 421
Query: 451 LLLSYGCDPNIISLQGFTALQMG-----NENVQQLLQEGISLGNSEADRQ--LLEAAKAG 503
LL G PN+ +++ T L M E + LLQ + D Q L AA+ G
Sbjct: 422 NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481
Query: 504 DVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPL 563
VK L + N TPLH AA V V LL+ A K G PL
Sbjct: 482 HTNMVKLLLE-NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
Query: 564 HNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNR 623
H A YG VAELL++ A N A TPLH A +I KLLL G P
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600
Query: 624 DGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSS-PDNVNCRDTQGRHSTP 682
+G TPL + AAK+ + + L + N QG TP
Sbjct: 601 NGYTPLHI--------------------AAKQNQVEVARSLLQYGGSANAESVQG--VTP 638
Query: 683 LHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATD 742
LHLAA + E+ LL A+ N +K GL PLH A GHV VA +LIK+ V+AT
Sbjct: 639 LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATT 698
Query: 743 KWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSA 802
+ +TPLH A+ G +L LL H AD K + G +PL + + ++T + A
Sbjct: 699 RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGA 758
Query: 803 LPSCYKPQVLNGVRSPGATADALS 826
P N V S G T A++
Sbjct: 759 SP--------NEVSSDGTTPLAIA 774
Score = 129 bits (325), Expect = 1e-29
Identities = 101/318 (31%), Positives = 150/318 (47%), Gaps = 19/318 (5%)
Query: 486 SLGNSEADR--QLLEAAKAGDVET----VKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRV 539
S+G EAD L AA++G+++ ++ + + N + G LH A+ V
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG-----LHLASKEGHV 58
Query: 540 SVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEA 599
+V LL + K G LH A G EV LV +GA VN FTPL+ A
Sbjct: 59 KMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 118
Query: 600 AAKGKYEICKLLLQHGADPTKKNRDGNTPLDL-VKDGDTDIQDLL-----RGDAAL--LD 651
A + E+ K LL++GA+ DG TPL + ++ G ++ L +G L L
Sbjct: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH 178
Query: 652 AAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKG 711
A + R + ++ N TPLH+AA Y NL VA+ LL GA VN +
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
Query: 712 GLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP 771
G+ PLH A+ G+V + LL+ A + K TPLH AA+ G ++ +LL HGA
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Query: 772 TLKNQEGQTPLDLVSADD 789
K + G +P+ + + D
Sbjct: 299 QAKTKNGLSPIHMAAQGD 316
Score = 90.5 bits (223), Expect = 8e-18
Identities = 57/152 (37%), Positives = 84/152 (55%), Gaps = 6/152 (3%)
Query: 15 SAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKS--TPLHFAAGFGRKD 72
SA AE+V+ L A + G E V L++ + + G KS TPLH A G
Sbjct: 627 SANAESVQ-GVTPLHLAAQEGHAEMVALLLSKQ---ANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 73 VVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAA 132
V + L+++G V A G PLH A +G+ ++V LL+H AD NA+ Y+PLH+AA
Sbjct: 683 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742
Query: 133 IKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA 164
+G D+ +LL++GA P ++DG T L +A
Sbjct: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 303 bits (775), Expect = 8e-82
Identities = 253/808 (31%), Positives = 373/808 (46%), Gaps = 65/808 (8%)
Query: 24 AARELFEACRNGDVER-VKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGA 82
AA A R+G++++ + L +N+ + G LH A+ G +V LL
Sbjct: 12 AATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELLHKEI 69
Query: 83 NVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIV 142
++ G LH A G EVV L+ +GA+ NA+ +TPL+ AA + ++V
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129
Query: 143 LLQHGAEPTIRNTDGRTALDLA------DPSAKAVLTGEYKKDEL--LESARSGNEEKMM 194
LL++GA + DG T L +A + A + G K L L A ++ +
Sbjct: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 189
Query: 195 ALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSY 254
A+L + N TPLH+AA Y + + QLLL GA V+ + + PLH A
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
Query: 255 GHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAI 314
G+ + LL+ GA + + TPLH AA V + +LL +GA + S I
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309
Query: 315 DLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAAS 374
+A + + LLQ E D ++L+ H T LH AA
Sbjct: 310 HMAAQGDHLDCV------RLLLQYDAEID------DITLD---------HLTPLHVAA-- 346
Query: 375 PYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQ 434
+ ++ ++LL KGA N + TPLH+A +K H V+E+++K A ++A+ G
Sbjct: 347 -HCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 405
Query: 435 TSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMG-----NENVQQLLQEGISLGN 489
T LH A++ GHL + LL G PN+ +++ T L M E + LLQ +
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465
Query: 490 SEADRQ--LLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQ 547
D Q L AA+ G V KL + N TPLH AA V V LL+
Sbjct: 466 KAKDDQTPLHCAARIGHTNMV-KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE 524
Query: 548 HGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEI 607
A K G PLH A YG VAELL++ A N A TPLH A +I
Sbjct: 525 KEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDI 584
Query: 608 CKLLLQHGADPTKKNRDGNTPL-------------DLVKDGDTDIQDLLRGDAALLDAAK 654
KLLL G P +G TPL L++ G + + ++G L AA+
Sbjct: 585 VKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQ 644
Query: 655 KGCLARVK-KLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGL 713
+G V LS N N + G TPLHL A ++ VA+ L++HG V+A + G
Sbjct: 645 EGHAEMVALLLSKQANGNLGNKSG--LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 702
Query: 714 IPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTL 773
PLH A+ YG++ + L+++ A VNA K ++PLH+AAQ+G T + LLL +GA P
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762
Query: 774 KNQEGQTPLDL------VSADDVSALLT 795
+ +G TPL + +S DV ++T
Sbjct: 763 VSSDGTTPLAIAKRLGYISVTDVLKVVT 790
Score = 297 bits (761), Expect = 3e-80
Identities = 252/804 (31%), Positives = 353/804 (43%), Gaps = 89/804 (11%)
Query: 31 ACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDG 90
A + G V+ V L+ E + T + +T LH AA G+ +VV L+ GANV A+
Sbjct: 52 ASKEGHVKMVVELLHKEII-LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 110
Query: 91 GLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEP 150
G PL+ A H EVV LL +GA+ N +TPL A +G +V L+ +G
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG--- 167
Query: 151 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGR 210
T G+ L L A ++ + A+L + N
Sbjct: 168 ----TKGKVRLPA------------------LHIAARNDDTRTAAVLLQNDPNPDVLSKT 205
Query: 211 KSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACV 270
TPLH+AA Y + + QLLL GA V+ + + PLH A G+ + LL+ GA +
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 271 NAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEF 330
+ TPLH AA V + +LL +GA + S I +A + +
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL-- 323
Query: 331 KGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKG 390
LLQ E D ++L+ H T LH AA + + + ++LL KG
Sbjct: 324 ----LLQYDAEID------DITLD---------HLTPLHVAAHCGHHR---VAKVLLDKG 361
Query: 391 ANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCR 450
A N + TPLH+A +K H V+E+++K A ++A+ G T LH A++ GHL +
Sbjct: 362 AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVK 421
Query: 451 LLLSYGCDPNIISLQGFTALQMG-----NENVQQLLQEGISLGNSEADRQ--LLEAAKAG 503
LL G PN+ +++ T L M E + LLQ + D Q L AA+ G
Sbjct: 422 NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481
Query: 504 DVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPL 563
VK L + N TPLH AA V V LL+ A K G PL
Sbjct: 482 HTNMVKLLLE-NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
Query: 564 HNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNR 623
H A YG VAELL++ A N A TPLH A +I KLLL G P
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600
Query: 624 DGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSS-PDNVNCRDTQGRHSTP 682
+G TPL + AAK+ + + L + N QG TP
Sbjct: 601 NGYTPLHI--------------------AAKQNQVEVARSLLQYGGSANAESVQG--VTP 638
Query: 683 LHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATD 742
LHLAA + E+ LL A+ N +K GL PLH A GHV VA +LIK+ V+AT
Sbjct: 639 LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATT 698
Query: 743 KWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSA 802
+ +TPLH A+ G +L LL H AD K + G +PL + + ++T + A
Sbjct: 699 RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGA 758
Query: 803 LPSCYKPQVLNGVRSPGATADALS 826
P N V S G T A++
Sbjct: 759 SP--------NEVSSDGTTPLAIA 774
Score = 129 bits (325), Expect = 1e-29
Identities = 101/318 (31%), Positives = 150/318 (47%), Gaps = 19/318 (5%)
Query: 486 SLGNSEADR--QLLEAAKAGDVET----VKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRV 539
S+G EAD L AA++G+++ ++ + + N + G LH A+ V
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG-----LHLASKEGHV 58
Query: 540 SVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEA 599
+V LL + K G LH A G EV LV +GA VN FTPL+ A
Sbjct: 59 KMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 118
Query: 600 AAKGKYEICKLLLQHGADPTKKNRDGNTPLDL-VKDGDTDIQDLL-----RGDAAL--LD 651
A + E+ K LL++GA+ DG TPL + ++ G ++ L +G L L
Sbjct: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH 178
Query: 652 AAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKG 711
A + R + ++ N TPLH+AA Y NL VA+ LL GA VN +
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
Query: 712 GLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP 771
G+ PLH A+ G+V + LL+ A + K TPLH AA+ G ++ +LL HGA
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Query: 772 TLKNQEGQTPLDLVSADD 789
K + G +P+ + + D
Sbjct: 299 QAKTKNGLSPIHMAAQGD 316
Score = 90.5 bits (223), Expect = 8e-18
Identities = 57/152 (37%), Positives = 84/152 (55%), Gaps = 6/152 (3%)
Query: 15 SAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKS--TPLHFAAGFGRKD 72
SA AE+V+ L A + G E V L++ + + G KS TPLH A G
Sbjct: 627 SANAESVQ-GVTPLHLAAQEGHAEMVALLLSKQ---ANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 73 VVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAA 132
V + L+++G V A G PLH A +G+ ++V LL+H AD NA+ Y+PLH+AA
Sbjct: 683 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742
Query: 133 IKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA 164
+G D+ +LL++GA P ++DG T L +A
Sbjct: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 303 bits (775), Expect = 8e-82
Identities = 253/808 (31%), Positives = 373/808 (46%), Gaps = 65/808 (8%)
Query: 24 AARELFEACRNGDVER-VKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGA 82
AA A R+G++++ + L +N+ + G LH A+ G +V LL
Sbjct: 12 AATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELLHKEI 69
Query: 83 NVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIV 142
++ G LH A G EVV L+ +GA+ NA+ +TPL+ AA + ++V
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129
Query: 143 LLQHGAEPTIRNTDGRTALDLA------DPSAKAVLTGEYKKDEL--LESARSGNEEKMM 194
LL++GA + DG T L +A + A + G K L L A ++ +
Sbjct: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 189
Query: 195 ALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSY 254
A+L + N TPLH+AA Y + + QLLL GA V+ + + PLH A
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
Query: 255 GHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAI 314
G+ + LL+ GA + + TPLH AA V + +LL +GA + S I
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309
Query: 315 DLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAAS 374
+A + + LLQ E D ++L+ H T LH AA
Sbjct: 310 HMAAQGDHLDCV------RLLLQYDAEID------DITLD---------HLTPLHVAA-- 346
Query: 375 PYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQ 434
+ ++ ++LL KGA N + TPLH+A +K H V+E+++K A ++A+ G
Sbjct: 347 -HCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 405
Query: 435 TSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMG-----NENVQQLLQEGISLGN 489
T LH A++ GHL + LL G PN+ +++ T L M E + LLQ +
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465
Query: 490 SEADRQ--LLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQ 547
D Q L AA+ G V KL + N TPLH AA V V LL+
Sbjct: 466 KAKDDQTPLHCAARIGHTNMV-KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE 524
Query: 548 HGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEI 607
A K G PLH A YG VAELL++ A N A TPLH A +I
Sbjct: 525 KEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDI 584
Query: 608 CKLLLQHGADPTKKNRDGNTPL-------------DLVKDGDTDIQDLLRGDAALLDAAK 654
KLLL G P +G TPL L++ G + + ++G L AA+
Sbjct: 585 VKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQ 644
Query: 655 KGCLARVK-KLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGL 713
+G V LS N N + G TPLHL A ++ VA+ L++HG V+A + G
Sbjct: 645 EGHAEMVALLLSKQANGNLGNKSG--LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 702
Query: 714 IPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTL 773
PLH A+ YG++ + L+++ A VNA K ++PLH+AAQ+G T + LLL +GA P
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762
Query: 774 KNQEGQTPLDL------VSADDVSALLT 795
+ +G TPL + +S DV ++T
Sbjct: 763 VSSDGTTPLAIAKRLGYISVTDVLKVVT 790
Score = 297 bits (761), Expect = 3e-80
Identities = 252/804 (31%), Positives = 353/804 (43%), Gaps = 89/804 (11%)
Query: 31 ACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDG 90
A + G V+ V L+ E + T + +T LH AA G+ +VV L+ GANV A+
Sbjct: 52 ASKEGHVKMVVELLHKEII-LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 110
Query: 91 GLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEP 150
G PL+ A H EVV LL +GA+ N +TPL A +G +V L+ +G
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG--- 167
Query: 151 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGR 210
T G+ L L A ++ + A+L + N
Sbjct: 168 ----TKGKVRLPA------------------LHIAARNDDTRTAAVLLQNDPNPDVLSKT 205
Query: 211 KSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACV 270
TPLH+AA Y + + QLLL GA V+ + + PLH A G+ + LL+ GA +
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 271 NAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEF 330
+ TPLH AA V + +LL +GA + S I +A + +
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL-- 323
Query: 331 KGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKG 390
LLQ E D ++L+ H T LH AA + + + ++LL KG
Sbjct: 324 ----LLQYDAEID------DITLD---------HLTPLHVAAHCGHHR---VAKVLLDKG 361
Query: 391 ANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCR 450
A N + TPLH+A +K H V+E+++K A ++A+ G T LH A++ GHL +
Sbjct: 362 AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVK 421
Query: 451 LLLSYGCDPNIISLQGFTALQMG-----NENVQQLLQEGISLGNSEADRQ--LLEAAKAG 503
LL G PN+ +++ T L M E + LLQ + D Q L AA+ G
Sbjct: 422 NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481
Query: 504 DVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPL 563
VK L + N TPLH AA V V LL+ A K G PL
Sbjct: 482 HTNMVKLLLE-NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
Query: 564 HNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNR 623
H A YG VAELL++ A N A TPLH A +I KLLL G P
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600
Query: 624 DGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSS-PDNVNCRDTQGRHSTP 682
+G TPL + AAK+ + + L + N QG TP
Sbjct: 601 NGYTPLHI--------------------AAKQNQVEVARSLLQYGGSANAESVQG--VTP 638
Query: 683 LHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATD 742
LHLAA + E+ LL A+ N +K GL PLH A GHV VA +LIK+ V+AT
Sbjct: 639 LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATT 698
Query: 743 KWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSA 802
+ +TPLH A+ G +L LL H AD K + G +PL + + ++T + A
Sbjct: 699 RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGA 758
Query: 803 LPSCYKPQVLNGVRSPGATADALS 826
P N V S G T A++
Sbjct: 759 SP--------NEVSSDGTTPLAIA 774
Score = 129 bits (325), Expect = 1e-29
Identities = 101/318 (31%), Positives = 150/318 (47%), Gaps = 19/318 (5%)
Query: 486 SLGNSEADR--QLLEAAKAGDVET----VKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRV 539
S+G EAD L AA++G+++ ++ + + N + G LH A+ V
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG-----LHLASKEGHV 58
Query: 540 SVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEA 599
+V LL + K G LH A G EV LV +GA VN FTPL+ A
Sbjct: 59 KMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 118
Query: 600 AAKGKYEICKLLLQHGADPTKKNRDGNTPLDL-VKDGDTDIQDLL-----RGDAAL--LD 651
A + E+ K LL++GA+ DG TPL + ++ G ++ L +G L L
Sbjct: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH 178
Query: 652 AAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKG 711
A + R + ++ N TPLH+AA Y NL VA+ LL GA VN +
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
Query: 712 GLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP 771
G+ PLH A+ G+V + LL+ A + K TPLH AA+ G ++ +LL HGA
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Query: 772 TLKNQEGQTPLDLVSADD 789
K + G +P+ + + D
Sbjct: 299 QAKTKNGLSPIHMAAQGD 316
Score = 90.5 bits (223), Expect = 8e-18
Identities = 57/152 (37%), Positives = 84/152 (55%), Gaps = 6/152 (3%)
Query: 15 SAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKS--TPLHFAAGFGRKD 72
SA AE+V+ L A + G E V L++ + + G KS TPLH A G
Sbjct: 627 SANAESVQ-GVTPLHLAAQEGHAEMVALLLSKQ---ANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 73 VVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAA 132
V + L+++G V A G PLH A +G+ ++V LL+H AD NA+ Y+PLH+AA
Sbjct: 683 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742
Query: 133 IKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA 164
+G D+ +LL++GA P ++DG T L +A
Sbjct: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 303 bits (775), Expect = 8e-82
Identities = 253/808 (31%), Positives = 373/808 (46%), Gaps = 65/808 (8%)
Query: 24 AARELFEACRNGDVER-VKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGA 82
AA A R+G++++ + L +N+ + G LH A+ G +V LL
Sbjct: 12 AATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELLHKEI 69
Query: 83 NVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIV 142
++ G LH A G EVV L+ +GA+ NA+ +TPL+ AA + ++V
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129
Query: 143 LLQHGAEPTIRNTDGRTALDLA------DPSAKAVLTGEYKKDEL--LESARSGNEEKMM 194
LL++GA + DG T L +A + A + G K L L A ++ +
Sbjct: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 189
Query: 195 ALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSY 254
A+L + N TPLH+AA Y + + QLLL GA V+ + + PLH A
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
Query: 255 GHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAI 314
G+ + LL+ GA + + TPLH AA V + +LL +GA + S I
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309
Query: 315 DLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAAS 374
+A + + LLQ E D ++L+ H T LH AA
Sbjct: 310 HMAAQGDHLDCV------RLLLQYDAEID------DITLD---------HLTPLHVAA-- 346
Query: 375 PYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQ 434
+ ++ ++LL KGA N + TPLH+A +K H V+E+++K A ++A+ G
Sbjct: 347 -HCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 405
Query: 435 TSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMG-----NENVQQLLQEGISLGN 489
T LH A++ GHL + LL G PN+ +++ T L M E + LLQ +
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465
Query: 490 SEADRQ--LLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQ 547
D Q L AA+ G V KL + N TPLH AA V V LL+
Sbjct: 466 KAKDDQTPLHCAARIGHTNMV-KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE 524
Query: 548 HGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEI 607
A K G PLH A YG VAELL++ A N A TPLH A +I
Sbjct: 525 KEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDI 584
Query: 608 CKLLLQHGADPTKKNRDGNTPL-------------DLVKDGDTDIQDLLRGDAALLDAAK 654
KLLL G P +G TPL L++ G + + ++G L AA+
Sbjct: 585 VKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQ 644
Query: 655 KGCLARVK-KLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGL 713
+G V LS N N + G TPLHL A ++ VA+ L++HG V+A + G
Sbjct: 645 EGHAEMVALLLSKQANGNLGNKSG--LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 702
Query: 714 IPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTL 773
PLH A+ YG++ + L+++ A VNA K ++PLH+AAQ+G T + LLL +GA P
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762
Query: 774 KNQEGQTPLDL------VSADDVSALLT 795
+ +G TPL + +S DV ++T
Sbjct: 763 VSSDGTTPLAIAKRLGYISVTDVLKVVT 790
Score = 297 bits (761), Expect = 3e-80
Identities = 252/804 (31%), Positives = 353/804 (43%), Gaps = 89/804 (11%)
Query: 31 ACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDG 90
A + G V+ V L+ E + T + +T LH AA G+ +VV L+ GANV A+
Sbjct: 52 ASKEGHVKMVVELLHKEII-LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK 110
Query: 91 GLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEP 150
G PL+ A H EVV LL +GA+ N +TPL A +G +V L+ +G
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG--- 167
Query: 151 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGR 210
T G+ L L A ++ + A+L + N
Sbjct: 168 ----TKGKVRLPA------------------LHIAARNDDTRTAAVLLQNDPNPDVLSKT 205
Query: 211 KSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACV 270
TPLH+AA Y + + QLLL GA V+ + + PLH A G+ + LL+ GA +
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 271 NAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEF 330
+ TPLH AA V + +LL +GA + S I +A + +
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL-- 323
Query: 331 KGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKG 390
LLQ E D ++L+ H T LH AA + + + ++LL KG
Sbjct: 324 ----LLQYDAEID------DITLD---------HLTPLHVAAHCGHHR---VAKVLLDKG 361
Query: 391 ANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCR 450
A N + TPLH+A +K H V+E+++K A ++A+ G T LH A++ GHL +
Sbjct: 362 AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVK 421
Query: 451 LLLSYGCDPNIISLQGFTALQMG-----NENVQQLLQEGISLGNSEADRQ--LLEAAKAG 503
LL G PN+ +++ T L M E + LLQ + D Q L AA+ G
Sbjct: 422 NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481
Query: 504 DVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPL 563
VK L + N TPLH AA V V LL+ A K G PL
Sbjct: 482 HTNMVKLLLE-NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
Query: 564 HNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNR 623
H A YG VAELL++ A N A TPLH A +I KLLL G P
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600
Query: 624 DGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSS-PDNVNCRDTQGRHSTP 682
+G TPL + AAK+ + + L + N QG TP
Sbjct: 601 NGYTPLHI--------------------AAKQNQVEVARSLLQYGGSANAESVQG--VTP 638
Query: 683 LHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATD 742
LHLAA + E+ LL A+ N +K GL PLH A GHV VA +LIK+ V+AT
Sbjct: 639 LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATT 698
Query: 743 KWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSA 802
+ +TPLH A+ G +L LL H AD K + G +PL + + ++T + A
Sbjct: 699 RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGA 758
Query: 803 LPSCYKPQVLNGVRSPGATADALS 826
P N V S G T A++
Sbjct: 759 SP--------NEVSSDGTTPLAIA 774
Score = 129 bits (325), Expect = 1e-29
Identities = 101/318 (31%), Positives = 150/318 (47%), Gaps = 19/318 (5%)
Query: 486 SLGNSEADR--QLLEAAKAGDVET----VKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRV 539
S+G EAD L AA++G+++ ++ + + N + G LH A+ V
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG-----LHLASKEGHV 58
Query: 540 SVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEA 599
+V LL + K G LH A G EV LV +GA VN FTPL+ A
Sbjct: 59 KMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 118
Query: 600 AAKGKYEICKLLLQHGADPTKKNRDGNTPLDL-VKDGDTDIQDLL-----RGDAAL--LD 651
A + E+ K LL++GA+ DG TPL + ++ G ++ L +G L L
Sbjct: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH 178
Query: 652 AAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKG 711
A + R + ++ N TPLH+AA Y NL VA+ LL GA VN +
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
Query: 712 GLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP 771
G+ PLH A+ G+V + LL+ A + K TPLH AA+ G ++ +LL HGA
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Query: 772 TLKNQEGQTPLDLVSADD 789
K + G +P+ + + D
Sbjct: 299 QAKTKNGLSPIHMAAQGD 316
Score = 90.5 bits (223), Expect = 8e-18
Identities = 57/152 (37%), Positives = 84/152 (55%), Gaps = 6/152 (3%)
Query: 15 SAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKS--TPLHFAAGFGRKD 72
SA AE+V+ L A + G E V L++ + + G KS TPLH A G
Sbjct: 627 SANAESVQ-GVTPLHLAAQEGHAEMVALLLSKQ---ANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 73 VVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAA 132
V + L+++G V A G PLH A +G+ ++V LL+H AD NA+ Y+PLH+AA
Sbjct: 683 VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742
Query: 133 IKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA 164
+G D+ +LL++GA P ++DG T L +A
Sbjct: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 248 bits (633), Expect = 2e-65
Identities = 242/807 (29%), Positives = 348/807 (43%), Gaps = 97/807 (12%)
Query: 28 LFEACRNGDVERVKRLV-TPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQA 86
L +A NGD + V+ L+ E VN +D K TPLH AA G +++E L+ +GA V A
Sbjct: 12 LVQAIFNGDPDEVRALIFKKEDVNFQDN--EKRTPLHAAAYLGDAEIIELLILSGARVNA 69
Query: 87 RDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARD-NWNYTPLHEAAIKGKIDVCIVLLQ 145
+D L PLH A + E V +LL+H AD NARD NW TPLH AA + L+
Sbjct: 70 KDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQ-TPLHIAAANKAVKCAEALVP 128
Query: 146 HGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCH 205
+ + + GRTAL +A SG+ E M+ LL N +
Sbjct: 129 LLSNVNVSDRAGRTALH--------------------HAAFSGHGE-MVKLLLSRGANIN 167
Query: 206 ASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK 265
A D + +H AA +++V+LL+ HGA+V KDK PLH A S G V + L+
Sbjct: 168 AFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLD 227
Query: 266 HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKER 325
G +N + + TPLH A + V + L+ GA ++N N+ TP
Sbjct: 228 LGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGA---IVNQKNEKGF----TPLHFAA 280
Query: 326 LAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICEL 385
+ L ADV +++ + K P H TALH R +
Sbjct: 281 ASTHGALCLELLVGNGADV-------NMKSKDGKTP-LHMTALH--------GRFSRSQT 324
Query: 386 LLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGH 445
+++ GA I+ + K TPLH+A+ H ++ ++ A G LH AA G
Sbjct: 325 IIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGF 384
Query: 446 LQTCRLLLSYGCDPNIISLQGFTALQM----GN-ENVQQLLQEGISLGNSEA-DRQLLEA 499
CR LLS G D + G T L GN E + LL G + R L
Sbjct: 385 SDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHY 444
Query: 500 AKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNR-VSVVEYLLQHGADVHAKDKG 558
A A + D++ R TPLH+AA + +EYLL++ A+ +DK
Sbjct: 445 AAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQ 504
Query: 559 GLVPLHNACSYGHYEVAELLVKHGAV-----VNVADLWK-------FTPLHEAAAKGKYE 606
G +H + +YGH +L+ + + D+ +PLH AA G ++
Sbjct: 505 GYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQ 564
Query: 607 ICKLLLQHGADPTKKNRDGNTPLDLVK-DGDTDIQDLLRGDAALLDAAKKGCLARVKKLS 665
++L+Q D +N G TPLDL G + D+L A + K L R
Sbjct: 565 ALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI-LVKDYILKR----- 618
Query: 666 SPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNA---QDKGGLIPLHNAASY 722
TP+H AA + E L+ + NA QD G PL +
Sbjct: 619 ---------------TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLN 663
Query: 723 GHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPL 782
GH D L+ A V+A DKW T LH A G + LL HGA L++ G+TP+
Sbjct: 664 GHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPI 723
Query: 783 DLVSA----DDVSALLTAAMPPSALPS 805
L +A + ALL +A A P+
Sbjct: 724 HLSAACGHIGVLGALLQSAASMDANPA 750
Score = 228 bits (582), Expect = 2e-59
Identities = 257/913 (28%), Positives = 371/913 (40%), Gaps = 127/913 (13%)
Query: 49 VNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVN 108
VN D AGR T LH AA G ++V+ LL GAN+ A D +H A GH EVV
Sbjct: 133 VNVSDRAGR--TALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 190
Query: 109 LLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSA 168
LL+ HGA+ +D +YTPLH AA G I V LL G + N G T L +A +
Sbjct: 191 LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 250
Query: 169 KAVLTGEY--------KKDE-----LLESARSGNEEKMMALLTP--LNVNCHASDGRKST 213
+ V+ E +K+E L +A S + + LL +VN + DG+ T
Sbjct: 251 QDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGK--T 308
Query: 214 PLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAM 273
PLH+ A + R Q ++Q GA + +DK PLH A YGH + L+ GA
Sbjct: 309 PLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKR 368
Query: 274 DLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAY----- 328
+ PLH AA + C LLS G D + ++ + A E L
Sbjct: 369 GIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTG 428
Query: 329 -------EFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQ 381
+F L AA + + + + T LH AA S +
Sbjct: 429 ADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGK-- 486
Query: 382 ICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTS----- 436
E LLR AN + K+ +H ++ H ++++ A LD L +TS
Sbjct: 487 CLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLI----ASETPLDVLMETSGTDML 542
Query: 437 -----------LHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGN-----ENVQQL 480
LH AAY GH Q +L+ D ++ + G T L + E V L
Sbjct: 543 SDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL 602
Query: 481 LQEGISLGNSE---ADRQLLEAAKAGDVETVKKLC-TVQSVNCRDIE-GRQSTPLHFAAG 535
+ +G S+ + + AA G E ++ L + N DI+ G TPL +
Sbjct: 603 INQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVL 662
Query: 536 YNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTP 595
V LL GA+V AKDK G LH GH E + L++HGA + D TP
Sbjct: 663 NGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTP 722
Query: 596 LHEAAAKGKYEICKLLLQHGA----DPTKKNRDGNTPLDLV--KDGDTDIQDLLRGDA-- 647
+H +AA G + LLQ A +P + G T L +T ++ LL +
Sbjct: 723 IHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQ 782
Query: 648 -------ALLDAA----KKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAE 696
+ L A +G + VN D++GR TPLH AA +++E +
Sbjct: 783 KTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGR--TPLHAAAFTDHVECLQ 840
Query: 697 YLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIK-----------------YNAC-- 737
LL H A VN+ D G PL AA G + +L+ + AC
Sbjct: 841 LLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSK 900
Query: 738 ------------------VNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQ 779
+NAT+ TPLH AA+ G T + LL GA ++ G
Sbjct: 901 GHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGY 960
Query: 780 TPLDLVSAD----DVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALS--SGPSSPS 833
TP + + D AL+ A M P + S N + T+ +S + P +
Sbjct: 961 TPALACAPNKDVADCLALILATMMPVSSSSPLSSLTFNAINRYTNTSKTVSFEALPIMRN 1020
Query: 834 SLSAASSLDNLSG 846
S+ S +N+ G
Sbjct: 1021 EPSSYCSFNNIGG 1033
Score = 196 bits (498), Expect = 1e-49
Identities = 159/466 (34%), Positives = 228/466 (48%), Gaps = 39/466 (8%)
Query: 334 SLLQAAREADVTRIKKHL-SLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGAN 392
SL+QA D ++ + E VNF+ + T LH AA Y +I ELL+ GA
Sbjct: 11 SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKR-TPLHAAA---YLGDAEIIELLILSGAR 66
Query: 393 INEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLL 452
+N K ++LTPLH A + V+V++KH A VNA D QT LH AA ++ L
Sbjct: 67 VNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126
Query: 453 LSYGCDPNIISLQGFTALQMG-----NENVQQLLQEGISLGN-SEADRQLLE-AAKAGDV 505
+ + N+ G TAL E V+ LL G ++ + DR+ + AA G +
Sbjct: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHI 186
Query: 506 ETVKKLCTVQS-VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLH 564
E VK L + + V C+D + TPLH AA +SVV+YLL G D++ + G PLH
Sbjct: 187 EVVKLLVSHGAEVTCKD--KKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLH 244
Query: 565 NACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEIC-KLLLQHGADPTKKNR 623
AC G V L+ GA+VN + FTPLH AAA +C +LL+ +GAD K++
Sbjct: 245 VACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSK 304
Query: 624 DGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKL-SSPDNVNCRDTQGRHSTP 682
DG TPL + A G +R + + S ++C D G +TP
Sbjct: 305 DGKTPLHMT--------------------ALHGRFSRSQTIIQSGAVIDCEDKNG--NTP 342
Query: 683 LHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATD 742
LH+AA Y + + L+ GAD + G+ PLH AA G D L+ ++ D
Sbjct: 343 LHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPD 402
Query: 743 KWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSAD 788
+ T LH AA G + LLL GAD K++ G++PL +A+
Sbjct: 403 DFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAAN 448
Score = 128 bits (322), Expect = 3e-29
Identities = 115/364 (31%), Positives = 164/364 (45%), Gaps = 49/364 (13%)
Query: 496 LLEAAKAGDVETVKKLC-TVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA 554
L++A GD + V+ L + VN +D E R TPLH AA ++E L+ GA V+A
Sbjct: 12 LVQAIFNGDPDEVRALIFKKEDVNFQDNEKR--TPLHAAAYLGDAEIIELLILSGARVNA 69
Query: 555 KDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQH 614
KD L PLH A + E ++L+KH A VN D TPLH AAA + + L+
Sbjct: 70 KDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPL 129
Query: 615 GADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPD-NVNCR 673
++ +R G T AL AA G VK L S N+N
Sbjct: 130 LSNVNVSDRAGRT--------------------ALHHAAFSGHGEMVKLLLSRGANINAF 169
Query: 674 DTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIK 733
D + R + +H AA ++EV + L+ HGA+V +DK PLH AAS G + V L+
Sbjct: 170 DKKDRRA--IHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLD 227
Query: 734 YNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSAL 793
+N + + TPLH A G+ + L+ GA KN++G TPL +A AL
Sbjct: 228 LGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGAL 287
Query: 794 LTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSS 853
C + V N GA + S +P ++A L G FS +
Sbjct: 288 ------------CLELLVGN-----GADVNMKSKDGKTPLHMTA------LHGRFSRSQT 324
Query: 854 VVSS 857
++ S
Sbjct: 325 IIQS 328
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 236 bits (603), Expect = 7e-62
Identities = 218/781 (27%), Positives = 349/781 (44%), Gaps = 81/781 (10%)
Query: 47 EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEV 106
E VN+ D+ K TPLH AA G +++E L+ +GA V A+D+ L PLH A + E
Sbjct: 7 EDVNTLDS--EKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEA 64
Query: 107 VNLLLRHGADPNARD-NWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLAD 165
V +L++H AD NARD NW TPLH AA + V++ + + + GRTAL
Sbjct: 65 VQVLIKHSADVNARDKNWQ-TPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH--- 120
Query: 166 PSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVK 225
+A +G+ E M+ LL N +A D + LH AA +
Sbjct: 121 -----------------HAALNGHVE-MVNLLLAKGANINAFDKKDRRALHWAAYMGHLD 162
Query: 226 IVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAA 285
+V LL+ HGA+V KDK PLH A S G V + L+ G ++ ++++ T LH A
Sbjct: 163 VVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIAC 222
Query: 286 SKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVT 345
+ V + L+ YGA+ N + + + A L E ++ ++
Sbjct: 223 YNGQDAVVNELIDYGANVNQPNNNGFTPLHFA-AASTHGALCLELLVNNGADVNIQSKDG 281
Query: 346 RIKKHLSLEMVNFKHPQT--------------HETALHCAAASPYPKRKQICELLLRKGA 391
+ H++ F QT T LH AA + + + L GA
Sbjct: 282 KSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGH---ELLINTLRTSGA 338
Query: 392 NINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRL 451
+ + + PLH+A+ AH+D ++ +++ D G+T LH AA G+++ +L
Sbjct: 339 DTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKL 398
Query: 452 LLSYGCDPNIISLQGFTALQMGNEN-----VQQLLQEGISLGNSEA-DRQLLEAAKAGDV 505
L S G D + G T L N ++ L+ G ++ ++ R L A A D+
Sbjct: 399 LQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDM 458
Query: 506 ETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHN 565
+ K + N ++E + A +E+LLQ+ A+ +DK G +H
Sbjct: 459 DRNKTILGNAHDNSEELERARELKEKEA-----TLCLEFLLQNDANPSIRDKEGYNSIHY 513
Query: 566 ACSYGHYEVAELLVKH---GAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKN 622
A +YGH + ELL++ G + + K +PLH AA G ++ ++LLQ D ++
Sbjct: 514 AAAYGHRQCLELLLERTNSGFEESDSGATK-SPLHLAAYNGHHQALEVLLQSLVDLDIRD 572
Query: 623 RDGNTPLDLVK-DGDTDIQDLLRGDAALL---DAAKKG-------------CLARVKKLS 665
G T LDL G T+ + L A + D K CL + +++
Sbjct: 573 EKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIA 632
Query: 666 -SPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGH 724
+P+ V+ +D +G+ TPL LA Y +++ LL+ A+V+ D G LH GH
Sbjct: 633 DNPEAVDVKDAKGQ--TPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGH 690
Query: 725 VDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHG---ADPTLKNQEGQTP 781
+ +L++ + D TPLH AA +G + LL D K+ +G TP
Sbjct: 691 EECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTP 750
Query: 782 L 782
L
Sbjct: 751 L 751
Score = 233 bits (593), Expect = 1e-60
Identities = 222/739 (30%), Positives = 326/739 (44%), Gaps = 96/739 (12%)
Query: 77 LLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGK 136
L+ +V D PLH A G AE++ LL+ GA NA+DN TPLH A
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
Query: 137 IDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMAL 196
+ VL++H A+ R+ + +T L +A + KAV E +
Sbjct: 62 EEAVQVLIKHSADVNARDKNWQTPLHVAAAN-KAVKCAE--------------------V 100
Query: 197 LTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGH 256
+ PL + + SD T LH AA V++V LLL GA+++A DK D LH A GH
Sbjct: 101 IIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGH 160
Query: 257 YEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDL 316
+V LL+ HGA V D +TPLH AAS ++ V LL+ G + +N + +A+
Sbjct: 161 LDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTAL-- 218
Query: 317 APTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHE-TALHCAAASP 375
H ++A V + + N P + T LH AAAS
Sbjct: 219 ----------------HIACYNGQDAVVNELIDY----GANVNQPNNNGFTPLHFAAAST 258
Query: 376 YPKRKQIC-ELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQ 434
+ +C ELL+ GA++N ++K+ +PLH+ + + ++++ +++ +D G
Sbjct: 259 H---GALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGN 315
Query: 435 TSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADR 494
T LH AA GH L + G D + L + N +S+ R
Sbjct: 316 TPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALN-----------AHSDCCR 364
Query: 495 QLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA 554
+LL + +++T K GR T LH AA V ++ L GAD H
Sbjct: 365 KLL--SSGFEIDTPDKF------------GR--TCLHAAAAGGNVECIKLLQSSGADFHK 408
Query: 555 KDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQH 614
KDK G PLH A + H+ E LV GA VN D W T LH AAA + K +L +
Sbjct: 409 KDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAA-SDMDRNKTILGN 467
Query: 615 GADPTK--------KNRDGNTPLD--LVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKL 664
D ++ K ++ L+ L D + I+D G ++ AA G ++ L
Sbjct: 468 AHDNSEELERARELKEKEATLCLEFLLQNDANPSIRD-KEGYNSIHYAAAYGHRQCLELL 526
Query: 665 SSPDNVNCRDT-QGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYG 723
N ++ G +PLHLAA + + E LLQ D++ +D+ G L AA G
Sbjct: 527 LERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKG 586
Query: 724 HVDVAALLIKYNACVNATDK-WAFTPLHEAAQKGRTQLCALLLAHGADP---TLKNQEGQ 779
H + LI A + D TPLH + G T LLL +P +K+ +GQ
Sbjct: 587 HTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQ 646
Query: 780 TPLDLVSA----DDVSALL 794
TPL L A D VS LL
Sbjct: 647 TPLMLAVAYGHIDAVSLLL 665
Score = 223 bits (567), Expect = 1e-57
Identities = 235/828 (28%), Positives = 340/828 (41%), Gaps = 121/828 (14%)
Query: 49 VNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVN 108
VN D GR T LH AA G ++V LL GAN+ A D LH A GH +VV
Sbjct: 108 VNVSDRGGR--TALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVA 165
Query: 109 LLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSA 168
LL+ HGA+ +D YTPLH AA G+I+V LL G E N G TAL +A +
Sbjct: 166 LLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNG 225
Query: 169 KAVLTGEYKKDELLESARSGNEEKMMALLTPLN---------------------VNCHAS 207
+ + +EL++ + N+ TPL+ VN +
Sbjct: 226 QDAVV-----NELIDYGANVNQPNNNGF-TPLHFAAASTHGALCLELLVNNGADVNIQSK 279
Query: 208 DGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHG 267
DG+ +PLH+ A + R Q L+Q+G ++ DK PLH A YGH + L G
Sbjct: 280 DGK--SPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSG 337
Query: 268 ACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLA 327
A + PLH AA + C LLS G + + ++ + A E +
Sbjct: 338 ADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECI- 396
Query: 328 YEFKGHSLLQAA-----READVTRIKKHLSLEMVNFKHPQT--------------HETAL 368
LLQ++ ++ R H + +F +T TAL
Sbjct: 397 ------KLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTAL 450
Query: 369 HCAAASPYPKRKQIC-------------------------ELLLRKGANINEKTKEFLTP 403
H AAAS + K I E LL+ AN + + KE
Sbjct: 451 HYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNS 510
Query: 404 LHVASEKAHNDVVEVVVKHEAKVNALDNLGQTS--LHRAAYCGHLQTCRLLLSYGCDPNI 461
+H A+ H +E++++ + G T LH AAY GH Q +LL D +I
Sbjct: 511 IHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDI 570
Query: 462 ISLQGFTALQMG-----NENVQQLLQEGISL---GNSEADRQLLEAAKAGDVETVKKLCT 513
+G TAL + E V+ L+ G S+ N L + G ++ L
Sbjct: 571 RDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLE 630
Query: 514 V----QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSY 569
+ ++V+ +D +G+ TPL A Y + V LL+ A+V D G LH
Sbjct: 631 IADNPEAVDVKDAKGQ--TPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMT 688
Query: 570 GHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGA---DPTKKNRDGN 626
GH E ++L++ + D TPLH AAA+G LLQ D K+ G
Sbjct: 689 GHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGY 748
Query: 627 TPLDLV--KDGDTDIQDLLRGDA--------------ALLDAAKKGCLARVKKLSSPDNV 670
TPL + I+ LL A+++ C + + V
Sbjct: 749 TPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIIND-HGNCASLLLGAIDSSIV 807
Query: 671 NCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAAL 730
+CRD +GR TPL AA +++E + LL+H A VNA D G L AA G +
Sbjct: 808 SCRDDKGR--TPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDI 865
Query: 731 LIKY-NACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQE 777
L+ A + DK TPLH A KG + L+L D +L N++
Sbjct: 866 LVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEK 913
Score = 191 bits (484), Expect = 5e-48
Identities = 178/614 (28%), Positives = 271/614 (44%), Gaps = 46/614 (7%)
Query: 208 DGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHG 267
D K TPLH+AA +I++LL+ GA V+AKD L PLH A + E ++L+KH
Sbjct: 13 DSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHS 72
Query: 268 ACVNAMDL-WQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERL 326
A VNA D WQ TPLH AA+ V+ ++ I L + + +R
Sbjct: 73 ADVNARDKNWQ-TPLHVAAANKAVKCAEVI-----------------IPLLSSVNVSDRG 114
Query: 327 AYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELL 386
H+ L E + K ++ + K + ALH AA Y + LL
Sbjct: 115 GRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRR----ALHWAA---YMGHLDVVALL 167
Query: 387 LRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHL 446
+ GA + K K+ TPLH A+ +VV+ ++ +++ ++ G T+LH A Y G
Sbjct: 168 INHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQD 227
Query: 447 QTCRLLLSYGCDPNIISLQGFTALQMGNEN------VQQLLQEGISLGNSEADRQLLEAA 500
L+ YG + N + GFT L + ++ L+ G + D +
Sbjct: 228 AVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHM 287
Query: 501 KAGDVETVKKLCTVQS---VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDK 557
A + +Q+ ++C D +G +TPLH AA Y ++ L GAD
Sbjct: 288 TAVHGRFTRSQTLIQNGGEIDCVDKDG--NTPLHVAARYGHELLINTLRTSGADTAKCGI 345
Query: 558 GGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGAD 617
+ PLH A H + L+ G ++ D + T LH AAA G E KLL GAD
Sbjct: 346 HSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGAD 405
Query: 618 PTKKNRDGNTPLDLVKDGDTD--IQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDT 675
KK++ G TPL I+ L+ A + + G A +S + N
Sbjct: 406 FHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTIL 465
Query: 676 QGRH--STPLHLAAGYNNLEVA---EYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAAL 730
H S L A E E+LLQ+ A+ + +DK G +H AA+YGH L
Sbjct: 466 GNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLEL 525
Query: 731 LI-KYNACVNATDKWAF-TPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSAD 788
L+ + N+ +D A +PLH AA G Q +LL D +++++G+T LDL +
Sbjct: 526 LLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFK 585
Query: 789 DVSALLTAAMPPSA 802
+ + A + P A
Sbjct: 586 GHTECVEALINPGA 599
Score = 183 bits (465), Expect = 7e-46
Identities = 173/589 (29%), Positives = 250/589 (42%), Gaps = 103/589 (17%)
Query: 229 LLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKN 288
+L+ DV+ D PLH A G E+ ELL+ GA VNA D TPLH A +
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 289 RVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIK 348
E +L+ + AD + + ++ + +A + +A + A+V I
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVA----------------AANKAVKCAEV--II 102
Query: 349 KHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVAS 408
LS V+ + TALH AA + + ++ LLL KGANIN K+ LH A+
Sbjct: 103 PLLSSVNVS---DRGGRTALHHAALNGH---VEMVNLLLAKGANINAFDKKDRRALHWAA 156
Query: 409 EKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFT 468
H DVV +++ H A+V D G T LH AA G + + LL+ G + + I++ G T
Sbjct: 157 YMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNT 216
Query: 469 ALQMGNENVQQ-LLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQS 527
AL + N Q ++ E I G N
Sbjct: 217 ALHIACYNGQDAVVNELIDYG----------------------------ANVNQPNNNGF 248
Query: 528 TPLHFAAGYNRVSV-VEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVN 586
TPLHFAA ++ +E L+ +GADV+ + K G PLH +G + ++ L+++G ++
Sbjct: 249 TPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEID 308
Query: 587 VADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGD 646
D TPLH AA G + L GAD K PL L
Sbjct: 309 CVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHL--------------- 353
Query: 647 AALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVN 706
A L+A C K LSS ++ D GR T LH AA N+E + L GAD +
Sbjct: 354 -AALNAHSDCCR---KLLSSGFEIDTPDKFGR--TCLHAAAAGGNVECIKLLQSSGADFH 407
Query: 707 AQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAA------------- 753
+DK G PLH AA+ H L+ A VN TD W T LH AA
Sbjct: 408 KKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGN 467
Query: 754 ---------------QKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSA 787
+K T LL + A+P+++++EG + +A
Sbjct: 468 AHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAA 516
Score = 143 bits (361), Expect = 8e-34
Identities = 183/677 (27%), Positives = 272/677 (40%), Gaps = 134/677 (19%)
Query: 49 VNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVN 108
VN + G+ +PLH A GR + L+QNG + D G PLH A +GH ++N
Sbjct: 274 VNIQSKDGK--SPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLIN 331
Query: 109 LLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSA 168
L GAD + PLH AA+ D C LL G E + GRT L A
Sbjct: 332 TLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAG- 390
Query: 169 KAVLTGEYKKDELLESARSGNEEKMMALLTPLN---VNCH---------------ASDGR 210
G + +LL+S+ + +K TPL+ NCH +D
Sbjct: 391 -----GNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDW 445
Query: 211 KSTPLHLAAG--YNRVKIV--------------------------QLLLQHGADVHAKDK 242
T LH AA +R K + + LLQ+ A+ +DK
Sbjct: 446 GRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDK 505
Query: 243 GDLVPLHNACSYGHYEVTELLVK--HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG 300
+H A +YGH + ELL++ + + +PLH AA + +LL
Sbjct: 506 EGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSL 565
Query: 301 ADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKH 360
D + + ++A+DLA FKGH+ E I S+ + K
Sbjct: 566 VDLDIRDEKGRTALDLAA-----------FKGHT------ECVEALINPGASIFV---KD 605
Query: 361 PQTHETALHCAAASPYPKRKQICELLLRKGAN----INEKTKEFLTPLHVASEKAHNDVV 416
T T LH + + + +C LL + A+ ++ K + TPL +A H D V
Sbjct: 606 NVTKRTPLHASVINGHT----LCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAV 661
Query: 417 EVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLL----------SYGCDP------- 459
++++ EA V+ +D LG T+LHR GH + ++LL S G P
Sbjct: 662 SLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAAR 721
Query: 460 -------NIISL------------QGFTALQM----GNENVQQLLQEGIS----LGNSEA 492
++ + QG+T L GNEN ++L E +GN
Sbjct: 722 GHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFT 781
Query: 493 DRQLLEAAKAGDVETVKKLCTVQS--VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGA 550
G+ ++ L + S V+CRD +GR TPL AA + V ++ LL+H A
Sbjct: 782 PLHCAIINDHGNCASLL-LGAIDSSIVSCRDDKGR--TPLRAAAFADHVECLQLLLRHSA 838
Query: 551 DVHAKDKGGLVPLHNACSYGHYEVAELLVKHG-AVVNVADLWKFTPLHEAAAKGKYEICK 609
V+A D G L A G ++LV A + V D TPLH A +KG +
Sbjct: 839 PVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCAL 898
Query: 610 LLLQHGADPTKKNRDGN 626
L+L D + N N
Sbjct: 899 LILDKIQDESLINEKNN 915
Score = 128 bits (322), Expect = 3e-29
Identities = 158/583 (27%), Positives = 243/583 (41%), Gaps = 90/583 (15%)
Query: 41 KRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACS 100
K L + ++++ D GR T LH AA G + ++ L +GA+ +D G PLH A +
Sbjct: 365 KLLSSGFEIDTPDKFGR--TCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAA 422
Query: 101 FGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKG------------------------- 135
H + L+ GA+ N D+W T LH AA
Sbjct: 423 NCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELK 482
Query: 136 --KIDVCI-VLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEK 192
+ +C+ LLQ+ A P+IR+ +G ++ A A + LLE SG EE
Sbjct: 483 EKEATLCLEFLLQNDANPSIRDKEGYNSIHYA-----AAYGHRQCLELLLERTNSGFEE- 536
Query: 193 MMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNAC 252
+ G +PLHLAA + +++LLQ D+ +D+ L A
Sbjct: 537 -------------SDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAA 583
Query: 253 SYGHYEVTELLVKHGACVNAMD-LWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNK 311
GH E E L+ GA + D + + TPLH + LLL +P ++ +
Sbjct: 584 FKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDA 643
Query: 312 SAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCA 371
TP L +AY GH +A ++K +++ V+ TALH
Sbjct: 644 KG----QTP-LMLAVAY---GHI------DAVSLLLEKEANVDTVDILGC----TALHRG 685
Query: 372 AASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAH----NDVVEVVVKHEAKVN 427
+ + ++ ++LL + +I K TPLH A+ + H ++++++ + E
Sbjct: 686 IMTGH---EECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEE-DCC 741
Query: 428 ALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMG----NENVQQLLQE 483
DN G T LH A Y G+ +LL C I FT L + N LL
Sbjct: 742 FKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIG-NPFTPLHCAIINDHGNCASLLLG 800
Query: 484 GI-----SLGNSEADRQLLEAAKAGDVETVKKLCTVQS-VNCRDIEGRQSTPLHFAAGYN 537
I S + + L AA A VE ++ L + VN D G+ T L AA
Sbjct: 801 AIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGK--TALMMAAENG 858
Query: 538 RVSVVEYLLQHG-ADVHAKDKGGLVPLHNACSYGHYEVAELLV 579
+ V+ L+ AD+ KDK PLH ACS GH + A L++
Sbjct: 859 QAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLIL 901
Score = 109 bits (272), Expect = 2e-23
Identities = 91/311 (29%), Positives = 132/311 (42%), Gaps = 69/311 (22%)
Query: 545 LLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGK 604
L+ DV+ D PLH A G E+ ELL+ GA VN D TPLH A A
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
Query: 605 YEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKL 664
E ++L++H AD
Sbjct: 62 EEAVQVLIKHSAD----------------------------------------------- 74
Query: 665 SSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGH 724
VN RD + TPLH+AA ++ AE ++ + VN D+GG LH+AA GH
Sbjct: 75 -----VNARDKNWQ--TPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGH 127
Query: 725 VDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDL 784
V++ LL+ A +NA DK LH AA G + ALL+ HGA+ T K+++G TPL
Sbjct: 128 VEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHA 187
Query: 785 VSADD----VSALLTAAMPPSALP---------SCYKPQ--VLNGVRSPGATADALSSGP 829
+++ V LL + + +CY Q V+N + GA + ++
Sbjct: 188 AASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNG 247
Query: 830 SSPSSLSAASS 840
+P +AAS+
Sbjct: 248 FTPLHFAAAST 258
Score = 87.4 bits (215), Expect = 7e-17
Identities = 85/286 (29%), Positives = 120/286 (41%), Gaps = 23/286 (8%)
Query: 46 PEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAE 105
PE V+ +D G+ TPL A +G D V LL+ ANV D G LH GH E
Sbjct: 635 PEAVDVKDAKGQ--TPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEE 692
Query: 106 VVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPT---IRNTDGRTALD 162
V +LL +D+ TPLH AA +G LLQ ++ G T L
Sbjct: 693 CVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLH 752
Query: 163 LA----DPSAKAVLTGEYKKDELLESARS----------GN-EEKMMALLTPLNVNCHAS 207
A + + VL + + + + + GN ++ + V+C
Sbjct: 753 WACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDD 812
Query: 208 DGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHG 267
GR TPL AA + V+ +QLLL+H A V+A D L A G ++LV
Sbjct: 813 KGR--TPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA 870
Query: 268 -ACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKS 312
A + D TPLH A SK + L+L D +L+N N +
Sbjct: 871 QADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKNNA 916
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 211 bits (538), Expect = 2e-54
Identities = 247/866 (28%), Positives = 352/866 (40%), Gaps = 143/866 (16%)
Query: 28 LFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQA 86
L +A + DVE V+ L++ E +N D R TPLH AA G +++ LL +GANV A
Sbjct: 12 LVQAIFSRDVEEVRSLLSQKENINVLDQERR--TPLHAAAYVGDVPILQLLLMSGANVNA 69
Query: 87 RDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 146
+D L PLH A + + +V+ LLL H AD NARD TPLH AA + C L
Sbjct: 70 KDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAA-ANRATKCAEAL-- 126
Query: 147 GAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHA 206
P + ++L++AD S ++ L + SG+ E + LL + +
Sbjct: 127 --APLL------SSLNVADRSGRSALH---------HAVHSGHLETVNLLLNK-GASLNV 168
Query: 207 SDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKH 266
D ++ PLH AA +++++LL+ GAD+ KD+ LH A + G EV + L++
Sbjct: 169 CDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRM 228
Query: 267 GACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERL 326
GA ++ + + T LH A + V L++ GA+ N + + +A L
Sbjct: 229 GAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAV-STNGAL 287
Query: 327 AYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELL 386
E L ADV K ++ LH AA R QI L
Sbjct: 288 CLE------LLVNNGADVNYQSKE-------------GKSPLHMAAIHGRFTRSQI---L 325
Query: 387 LRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHL 446
++ G+ I+ K TPLHVA+ H ++ ++ + A LH A G
Sbjct: 326 IQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFS 385
Query: 447 QTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVE 506
CR LLS G +I+S + NE+V L G
Sbjct: 386 DCCRKLLSSGQLYSIVS-------SLSNEHV---LSAGF--------------------- 414
Query: 507 TVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNA 566
+N D GR T LH AA V + LL GAD+ +DK G PLH A
Sbjct: 415 ---------DINTPDNLGR--TCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYA 463
Query: 567 CSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYE-------------------- 606
+ G Y+ A LV GA VN AD +PLH AAA Y
Sbjct: 464 AANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKE 523
Query: 607 --------ICKLLLQHGADPTKKNRDGNTP----------------LDLVKDGDTDIQDL 642
+ LL +GADP+ ++R G T L++ + D++
Sbjct: 524 SRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVEST 583
Query: 643 LRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHG 702
+ L A C A + N++ RD +GR T L LA + E E L HG
Sbjct: 584 IPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGR--TALFLATERGSTECVEVLTAHG 641
Query: 703 ADVNAQD-KGGLIPLHNAASYGHVDVAALLIKYNACVNAT---DKWAFTPLHEAAQKGRT 758
A ++ K PLH AA+ GH D LLI + T D + TPL A G
Sbjct: 642 ASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHV 701
Query: 759 QLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVRSP 818
LLL G+ + G+T L + L A + A C + G R+P
Sbjct: 702 DCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLC---RDFKG-RTP 757
Query: 819 GATADALSSGPSSPSSLSAASSLDNL 844
A A + L AA S D L
Sbjct: 758 IHLASACGHTAVLRTLLQAALSTDPL 783
Score = 196 bits (497), Expect = 1e-49
Identities = 248/904 (27%), Positives = 370/904 (40%), Gaps = 118/904 (13%)
Query: 28 LFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQA 86
L A +G +E VK L+ +++ + G +T LH A G+ V L+ GANV
Sbjct: 210 LHTAAASGQIEVVKYLLRMGAEIDEPNAFG--NTALHIACYLGQDAVAIELVNAGANVNQ 267
Query: 87 RDDGGLIPLHNAC-SFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 145
+D G PLH A S A + LL+ +GAD N + +PLH AAI G+ +L+Q
Sbjct: 268 PNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQ 327
Query: 146 HGAEPTIRNTDGRTALDLAD---------------------------PSAKAVLTGEYKK 178
+G+E + G T L +A P AVL G
Sbjct: 328 NGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGF--S 385
Query: 179 DELLESARSGNEEKMMALLTPLNV-----NCHASDGRKSTPLHLAAGYNRVKIVQLLLQH 233
D + SG +++ L+ +V + + D T LH AA V+ + LLL
Sbjct: 386 DCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSS 445
Query: 234 GADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVC 293
GAD+ +DK PLH A + G Y+ LV GA VN D +PLH AA+ +
Sbjct: 446 GADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRA 505
Query: 294 S--LLLSYGA--DPTLLNCHNKSA-------IDLAPTPQLKERLAYEFKGHSLLQAAREA 342
S+ A D L K A +D P L++R Y ++ R+
Sbjct: 506 EPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQN 565
Query: 343 DVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKR-KQICELLLRKGANINEKTKEFL 401
+ +S + + LH AA + + + K + E L+ N++ + +
Sbjct: 566 --LELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLV----NLDVRDHKGR 619
Query: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQ-TSLHRAAYCGHLQTCRLLLSYGCDPN 460
T L +A+E+ + VEV+ H A + + T LH AA GH + LL+ G +
Sbjct: 620 TALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERAD 679
Query: 461 IISLQ---GFTALQMGNEN-----VQQLLQEGISLGNSEADRQ--LLEAAKAGDVETVKK 510
I + G T L + N V LL++G + ++ + L A G + +
Sbjct: 680 ITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAA 739
Query: 511 LCTVQS-VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKG----GLVPLHN 565
L + V CRD +GR TP+H A+ +V+ LLQ D G G P+H
Sbjct: 740 LLDHDAFVLCRDFKGR--TPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHW 797
Query: 566 ACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRD- 624
A GH + ELL++H + + FTPLH A + ++LL +RD
Sbjct: 798 ASYTGHEDCLELLLEHSPF-SYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDA 856
Query: 625 -GNTPLDLVKDGD--TDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHST 681
G TPL D + ++ LL+ A VN D GR T
Sbjct: 857 KGRTPLHAAAFADNVSGLRMLLQHQA---------------------EVNATDHTGR--T 893
Query: 682 PLHLAAGYNNLEVAEYLLQHG-ADVNAQDKGGLIPLHNAASYGHVDVAALLIKYN---AC 737
L AA E+LL G AD+ D+ LH A S GH A +++
Sbjct: 894 ALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGL 953
Query: 738 VNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSAD----DVSAL 793
+NAT+ PLH AA+ G + LL+HGA ++EG TP + + D AL
Sbjct: 954 INATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLAL 1013
Query: 794 LTAAM---PPSALPSCYKPQVLNGVRSPGAT----ADALSSGPSSPSSLSAASSLDNLSG 846
+ + M PP S + +L A AL G S P S ++ L G
Sbjct: 1014 ILSTMKPFPPKDAVSPFSFSLLKNCSIAAAKTVGGCGALPHGASCPYSQERPGAI-GLDG 1072
Query: 847 SFSE 850
+SE
Sbjct: 1073 CYSE 1076
Score = 185 bits (470), Expect = 2e-46
Identities = 179/606 (29%), Positives = 264/606 (43%), Gaps = 89/606 (14%)
Query: 214 PLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAM 273
PL A V+ V+ LL +++ D+ PLH A G + +LL+ GA VNA
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
Query: 274 DLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGH 333
D TPLH AA+ +V LLL++ AD +N +K L TP
Sbjct: 71 DTLWLTPLHRAAASRNEKVLGLLLAHSAD---VNARDK----LWQTP------------- 110
Query: 334 SLLQAAREADVTRIKKHLS--LEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGA 391
L A T+ + L+ L +N ++ +ALH A S + + LLL KGA
Sbjct: 111 --LHVAAANRATKCAEALAPLLSSLNVA-DRSGRSALHHAVHSGH---LETVNLLLNKGA 164
Query: 392 NINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRL 451
++N K+ PLH A+ H +V++++V A + D G LH AA G ++ +
Sbjct: 165 SLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKY 224
Query: 452 LLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKL 511
LL G + + + G TAL + LG D +E AG
Sbjct: 225 LLRMGAEIDEPNAFGNTALHI-----------ACYLGQ---DAVAIELVNAG-------- 262
Query: 512 CTVQSVNCRDIEGRQSTPLHFAA-GYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYG 570
N + TPLH AA N +E L+ +GADV+ + K G PLH A +G
Sbjct: 263 -----ANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHG 317
Query: 571 HYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLD 630
+ +++L+++G+ ++ AD + TPLH AA G + L+ +GAD ++ PL
Sbjct: 318 RFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLH 377
Query: 631 L-VKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGY 689
L V G +D L L L+ LS+ ++N D GR T LH AA
Sbjct: 378 LAVLFGFSDCCRKLLSSGQLYSIVSS--LSNEHVLSAGFDINTPDNLGR--TCLHAAASG 433
Query: 690 NNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPL 749
N+E LL GAD+ +DK G PLH AA+ G A L+ A VN D +PL
Sbjct: 434 GNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPL 493
Query: 750 HEAA----------------------------QKGRTQLCALLLAHGADPTLKNQEGQTP 781
H AA +K LL +GADP+L++++G T
Sbjct: 494 HYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTA 553
Query: 782 LDLVSA 787
+ +A
Sbjct: 554 VHYAAA 559
Score = 106 bits (264), Expect = 1e-22
Identities = 86/279 (30%), Positives = 128/279 (45%), Gaps = 16/279 (5%)
Query: 529 PLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVA 588
PL A V V LL +++ D+ PLH A G + +LL+ GA VN
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
Query: 589 DLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDL-VKDGDTDIQDLL---- 643
D TPLH AAA ++ LLL H AD +++ TPL + + T + L
Sbjct: 71 DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130
Query: 644 --------RGDAALLDAAKKGCLARVK-KLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEV 694
G +AL A G L V L+ ++N D + R PLH AA +LEV
Sbjct: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQ--PLHWAAFLGHLEV 188
Query: 695 AEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQ 754
+ L+ GAD+ +D+ G LH AA+ G ++V L++ A ++ + + T LH A
Sbjct: 189 LKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACY 248
Query: 755 KGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSAL 793
G+ + L+ GA+ N +G TPL + + AL
Sbjct: 249 LGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGAL 287
Score = 67.0 bits (162), Expect = 1e-10
Identities = 42/118 (35%), Positives = 58/118 (49%)
Query: 682 PLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNAT 741
PL A ++E LL ++N D+ PLH AA G V + LL+ A VNA
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
Query: 742 DKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMP 799
D TPLH AA ++ LLLAH AD +++ QTPL + +A+ + A P
Sbjct: 71 DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAP 128
Score = 35.8 bits (81), Expect = 0.24
Identities = 27/88 (30%), Positives = 37/88 (42%)
Query: 715 PLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLK 774
PL A V+ L+ +N D+ TPLH AA G + LLL GA+ K
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
Query: 775 NQEGQTPLDLVSADDVSALLTAAMPPSA 802
+ TPL +A +L + SA
Sbjct: 71 DTLWLTPLHRAAASRNEKVLGLLLAHSA 98
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 206 bits (523), Expect = 1e-52
Identities = 226/802 (28%), Positives = 343/802 (42%), Gaps = 112/802 (13%)
Query: 14 ASAAAEAVEPAARELFEACRNGDVERVKR-LVTPEKVNSRDTAGRKSTPLHFAAGFGRKD 72
A + A A + R L EAC GDV V++ L+ VN G L +AG+ +
Sbjct: 224 AESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGY--YE 281
Query: 73 VVEYLLQNGANVQARD-DGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEA 131
+ + LL ANV+ R G + PL A + GH ++V LLL H AD NA+ + T L A
Sbjct: 282 LAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYA 341
Query: 132 AIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEE 191
G +DV VLL+ GA N +G T L+E+ +G+ E
Sbjct: 342 CAGGYVDVVKVLLESGASIEDHNENGHT--------------------PLMEAGSAGHVE 381
Query: 192 KMMALL-TPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHN 250
LL +N H+++ ++S L LA +++V+ LL+ GAD K L
Sbjct: 382 VARLLLENGAGINTHSNEFKESA-LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALME 440
Query: 251 ACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHN 310
AC GH EV LL+ GA VN +PL AA VE+ +LL+ GA +N
Sbjct: 441 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVN--- 497
Query: 311 KSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSL-EMVNFKHPQTHETALH 369
D TP L++AARE + L +N + +T ETAL
Sbjct: 498 ----DEGYTP--------------LMEAAREGHEEMVALLLGQGANINAQTEETQETALT 539
Query: 370 CAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNAL 429
A + ++ + L++ GA+I TPL A+++ H ++V+ ++ A V+A
Sbjct: 540 LACCGGF---LEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHAT 593
Query: 430 DNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGN 489
G T+L A GH +LL G D S G T
Sbjct: 594 TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRT--------------------- 632
Query: 490 SEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHG 549
L++AA+AG V TV+ L + + R T L A ++VVE LL HG
Sbjct: 633 -----PLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHG 687
Query: 550 ADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVA---DLWKFT-PLHEAAAKGKY 605
AD + K G L A GH V L+ + + A D+ + T P H+ +
Sbjct: 688 ADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRV 747
Query: 606 EICKL-LLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDA-ALLDAAKKGCLARVKK 663
+ L ++ +P K + T L + + G A A+ + A + +
Sbjct: 748 PVQALPMVVPPQEPDKPPANVATTLPIRNKA-------VSGRASAMSNTPTHSIAASISQ 800
Query: 664 LSSPD-----------------NVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVN 706
+P +++ + T+ H T L LA + E+ + LL+ GA +
Sbjct: 801 PQTPTPSPIISPSAMLPIYPAIDIDAQ-TESNHDTALTLACAGGHEELVQTLLERGASIE 859
Query: 707 AQDKGGLIPLHNAASYGHVDVAALLIKYNACVNA-TDKWAFTPLHEAAQKGRTQLCALLL 765
+DK G PL AA+ GHV V +L+ A + A +++ TPL A GR ++ LLL
Sbjct: 860 HRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLL 919
Query: 766 AHGADPTLKNQEGQTPLDLVSA 787
A GA+ +N TPL L ++
Sbjct: 920 ARGANKEHRNVSDYTPLSLAAS 941
Score = 172 bits (436), Expect = 2e-42
Identities = 213/781 (27%), Positives = 323/781 (41%), Gaps = 137/781 (17%)
Query: 28 LFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQAR 87
L EAC +G VE V RL+ A +PL AA G ++ L++ GA+++
Sbjct: 438 LMEACMDGHVE-VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEV 496
Query: 88 DDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNY---------------------- 125
+D G PL A GH E+V LLL GA+ NA+
Sbjct: 497 NDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKA 556
Query: 126 ---------TPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTAL---------DLADPS 167
TPL EAA +G +++ LL GA G TAL D+AD
Sbjct: 557 GADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVL 616
Query: 168 AKAVLTGEYKKD----ELLESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLHLAAGYN 222
+A E++ + L+++AR+G+ + L++ NVN + T L LA
Sbjct: 617 LQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVN-RTTANNDHTVLSLACAGG 675
Query: 223 RVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAM---DLWQFT 279
+ +V+LLL HGAD + K L A GH V L+ + + + D+ Q T
Sbjct: 676 HLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLT 735
Query: 280 P-LHEAASKNRVEVCSL-LLSYGADP--------TLLNCHNK------SAIDLAPTPQLK 323
P H+ RV V +L ++ +P T L NK SA+ PT +
Sbjct: 736 PPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIA 795
Query: 324 ERLAYEFKGHSLLQAAREADVTRIKKHLSLEM---VNFKHPQTHETALHCAAASPYPKRK 380
++ Q + + L + ++ + H+TAL A A + +
Sbjct: 796 ASISQP-------QTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGH---E 845
Query: 381 QICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNAL-DNLGQTSLHR 439
++ + LL +GA+I + K+ TPL +A+ H VVE+++ + A + A + T L
Sbjct: 846 ELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSL 905
Query: 440 AAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEA 499
A G + LLL+ G + ++ +T L + A
Sbjct: 906 ACSGGRQEVVELLLARGANKEHRNVSDYTPLSL--------------------------A 939
Query: 500 AKAGDVETVKKLCTVQS-VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAK-DK 557
A G V +K L + +N R +PL AA + V+ LL G+D++A+ +
Sbjct: 940 ASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIET 999
Query: 558 GGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGAD 617
L AC G EV LL+ A V TPL EAA+ G E+ ++LL GAD
Sbjct: 1000 NRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGAD 1059
Query: 618 ----PTKKNRDGNTPLDLVKD-GDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNC 672
P +RD T L + D G +LL G A +D K
Sbjct: 1060 VNAPPVPSSRD--TALTIAADKGHYKFCELLIGRGAHIDVRNK----------------- 1100
Query: 673 RDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLI 732
+ +TPL LAA +L+V + L+Q GADV+A D + PL A GHV V L+
Sbjct: 1101 -----KGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1155
Query: 733 K 733
K
Sbjct: 1156 K 1156
Score = 167 bits (423), Expect = 5e-41
Identities = 223/836 (26%), Positives = 338/836 (40%), Gaps = 159/836 (19%)
Query: 98 ACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDG 157
+C+ A +R + NA + N + L EA +G ++ LL G +G
Sbjct: 209 SCALDEAAAALTRMRAESTANAGQSDNRS-LAEACSEGDVNAVRKLLIEGRSVNEHTEEG 267
Query: 158 RTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKS--TPL 215
+ L LA + G Y+ ++L + + E++ G K TPL
Sbjct: 268 ESLLCLACSA------GYYELAQVLLAMHANVEDR----------------GIKGDITPL 305
Query: 216 HLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDL 275
AA VKIV+LLL H ADV+A+ L AC+ G+ +V ++L++ GA + +
Sbjct: 306 MAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNE 365
Query: 276 WQFTPLHEAASKNRVEVCSLLLSYGAD-PTLLNCHNKSAIDLAPTPQLKERLAYEFKGHS 334
TPL EA S VEV LLL GA T N +SA+ LA +KGH
Sbjct: 366 NGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLAC-----------YKGH- 413
Query: 335 LLQAAREADVTRIKKHLSLEMVNF----KHPQTHET-ALHCAAASP-YPKRKQICELLLR 388
LEMV F Q H+T +H A ++ LLL
Sbjct: 414 ------------------LEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 455
Query: 389 KGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQT 448
GA +N F +PL +A+ H ++ ++++ A + +++ G T L AA GH +
Sbjct: 456 SGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEM 515
Query: 449 CRLLLSYGCDPNIISLQ-GFTALQMG-----NENVQQLLQEG--ISLGNSEADRQLLEAA 500
LLL G + N + + TAL + E L++ G I LG S L+EAA
Sbjct: 516 VALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAA 572
Query: 501 KAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGL 560
+ G +E VK L N T L +A V + LLQ GAD+ + +GG
Sbjct: 573 QEGHLELVKYLLAA-GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGR 631
Query: 561 VPLHNACSYGHYEVAELLVKHGAVVNVADLWK-FTPLHEAAAKGKYEICKLLLQHGADPT 619
PL A GH + L+ GA VN T L A A G + +LLL HGADPT
Sbjct: 632 TPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPT 691
Query: 620 KKNRDGNTPL-DLVKDGDTDI--------------------------QDLLRGDAALLDA 652
+ +DG+T L + K G T + DL R + A
Sbjct: 692 HRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQA 751
Query: 653 AKKGCLARVKKLSSPDN----------VNCRDTQGRHS----TPLH-LAAGYNNLEV--- 694
L V PD + + GR S TP H +AA + +
Sbjct: 752 -----LPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTP 806
Query: 695 -------AEYLLQHGADVNAQDKGGL-IPLHNAASYGHVDVAALLIKYNACVNATDKWAF 746
A + D++AQ + L A + GH ++ L++ A + DK F
Sbjct: 807 SPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGF 866
Query: 747 TPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQ-TPLDLVSADDVSALLTAAMPPSALPS 805
TPL AA G + +LL +GAD +++ + TPL L +
Sbjct: 867 TPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGG---------------- 910
Query: 806 CYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSSGTE 861
+ +V+ + + GA + + +P SL+A SG + + ++ ++G E
Sbjct: 911 --RQEVVELLLARGANKEHRNVSDYTPLSLAA-------SGGYVNIIKILLNAGAE 957
Score = 162 bits (410), Expect = 2e-39
Identities = 200/749 (26%), Positives = 312/749 (41%), Gaps = 117/749 (15%)
Query: 301 ADPTLLNCHNKS---AIDLAPTPQLKERL-----AYEFKGHSLLQAAREADVTRIKKHLS 352
ADP +L S A+D A + R A + SL +A E DV ++K L
Sbjct: 196 ADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLI 255
Query: 353 LEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEK-TKEFLTPLHVASEKA 411
+H + E+ L A ++ Y ++ ++LL AN+ ++ K +TPL A+
Sbjct: 256 EGRSVNEHTEEGESLLCLACSAGY---YELAQVLLAMHANVEDRGIKGDITPLMAAANGG 312
Query: 412 HNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQ 471
H +V++++ H+A VNA + G T+L A G++ ++LL G +++
Sbjct: 313 HVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGA-----------SIE 361
Query: 472 MGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLH 531
NEN L E S G+ E R LLE +N E ++S L
Sbjct: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAG--------------INTHSNEFKESA-LT 406
Query: 532 FAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV-ADL 590
A + +V +LL+ GAD K L AC GH EVA LL+ GA VN+ AD
Sbjct: 407 LACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 466
Query: 591 WKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPL-DLVKDGDTDIQDLLRGDAA- 648
++ +PL AA G E+ LL++ GA + N +G TPL + ++G ++ LL G A
Sbjct: 467 FE-SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGAN 525
Query: 649 ------------------------------------------LLDAAKKGCLARVKKLSS 666
L++AA++G L VK L +
Sbjct: 526 INAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLA 585
Query: 667 PDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVD 726
N T T L A + +VA+ LLQ GAD+ + +GG PL AA GHV
Sbjct: 586 A-GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVC 644
Query: 727 VAALLIKYNACVNATD-KWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPL-DL 784
LI A VN T T L A G + LLLAHGADPT + ++G T L +
Sbjct: 645 TVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEA 704
Query: 785 VSADDVSAL---------LTAAMPPSALPSCYKPQVLNGVRSPGATADALSS--GPSSPS 833
S + L +A PP LN R+P AL P P
Sbjct: 705 AKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLN--RAPRVPVQALPMVVPPQEPD 762
Query: 834 S--LSAASSLDNLSGSFSELSSVVSSSGTEG-ASSLEKKEVPGVDFSITQFVRNLGLEHL 890
+ A++L + + S +S +S++ T A+S+ + + P I+ L +
Sbjct: 763 KPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAM-LPIYPA 821
Query: 891 MDIFEREQITLDVLVEM----GHKELKEIGINAYGHRHKLIKGVERLISGQQGLNPYLTL 946
+DI + + D + + GH+EL + L +G ++G P +
Sbjct: 822 IDIDAQTESNHDTALTLACAGGHEELVQT---------LLERGASIEHRDKKGFTPLILA 872
Query: 947 NTSGSGTILIDLSPDDKEFQSVEEEMQST 975
T+G ++ L + + ++ E + T
Sbjct: 873 ATAGHVGVVEILLDNGADIEAQSERTKDT 901
Score = 118 bits (295), Expect = 4e-26
Identities = 99/296 (33%), Positives = 136/296 (45%), Gaps = 21/296 (7%)
Query: 523 EGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHG 582
E T L A +V+ LL+ GA + +DK G PL A + GH V E+L+ +G
Sbjct: 829 ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 888
Query: 583 AVVNV-ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGD--TDI 639
A + ++ K TPL A + G+ E+ +LLL GA+ +N TPL L G I
Sbjct: 889 ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 948
Query: 640 QDLLR-------------GDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLA 686
+ LL G + L+ AA G A VK L + + +T L LA
Sbjct: 949 KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLA 1008
Query: 687 AGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNA--TDKW 744
EV LL A+V + K GL PL AAS G+ +V +L+ A VNA
Sbjct: 1009 CFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1068
Query: 745 AFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSAD---DVSALLTAA 797
T L AA KG + C LL+ GA ++N++G TPL L + DV LL A
Sbjct: 1069 RDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQA 1124
Score = 108 bits (271), Expect = 2e-23
Identities = 130/437 (29%), Positives = 182/437 (41%), Gaps = 65/437 (14%)
Query: 31 ACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDD 89
AC G E V+ L+ + RD G TPL AA G VVE LL NGA+++A+ +
Sbjct: 839 ACAGGHEELVQTLLERGASIEHRDKKG--FTPLILAATAGHVGVVEILLDNGADIEAQSE 896
Query: 90 GGL-IPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGA 148
PL ACS G EVV LLL GA+ R+ +YTPL AA G +++ +LL GA
Sbjct: 897 RTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGA 956
Query: 149 EPTIRN-------------TDGRTA-----LDL-ADPSAK-----------AVLTGEYKK 178
E R +G TA LD+ +D +A+ A G +
Sbjct: 957 EINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEV 1016
Query: 179 DELLESARSGNEEKMMALLTPL--------------------NVNCHASDGRKSTPLHLA 218
LL ++ E + LTPL +VN + T L +A
Sbjct: 1017 VSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIA 1076
Query: 219 AGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQF 278
A K +LL+ GA + ++K PL A + GH +V +LLV+ GA V+A D +
Sbjct: 1077 ADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKI 1136
Query: 279 TPLHEAASKNRVEVCSLLL-SYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQ 337
TPL A K V+V L+ P+ C A K L E S++Q
Sbjct: 1137 TPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCME----SIVQ 1192
Query: 338 AAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQ----ICELLLRKGANI 393
A++ K+ S+ + + E + A A+ KRK+ E RK I
Sbjct: 1193 -AKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEI 1251
Query: 394 NEKTKEFLTPLHVASEK 410
K KE L A EK
Sbjct: 1252 EAKNKENF-ELQAAQEK 1267
Score = 104 bits (259), Expect = 6e-22
Identities = 101/315 (32%), Positives = 145/315 (46%), Gaps = 29/315 (9%)
Query: 475 ENVQQLLQEGISLGNSEAD--RQLLEAAKAGDVETVKKLCTVQSVNCRDIEGR----QST 528
E VQ LL+ G S+ + + L+ AA AG V V+ L N DIE + + T
Sbjct: 846 ELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD----NGADIEAQSERTKDT 901
Query: 529 PLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVA 588
PL A R VVE LL GA+ ++ PL A S G+ + ++L+ GA +N
Sbjct: 902 PLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSR 961
Query: 589 DLWKF--TPLHEAAAKGKYEICKLLLQHGADPTKK-NRDGNTPLDLVK-DGDTDIQDLL- 643
K +PL AA G KLLL G+D + + NT L L G T++ LL
Sbjct: 962 TGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLL 1021
Query: 644 -----------RGDAALLDAAKKGCLARVKK--LSSPDNVNCRDTQGRHSTPLHLAAGYN 690
G L++AA G A V + L +VN T L +AA
Sbjct: 1022 DRKANVEHRAKTGLTPLMEAASGG-YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1080
Query: 691 NLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLH 750
+ + E L+ GA ++ ++K G PL AA+ GH+DV LL++ A V+A D TPL
Sbjct: 1081 HYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLM 1140
Query: 751 EAAQKGRTQLCALLL 765
A +KG ++ L+
Sbjct: 1141 AAFRKGHVKVVRYLV 1155
Score = 98.2 bits (243), Expect = 4e-20
Identities = 96/315 (30%), Positives = 138/315 (43%), Gaps = 16/315 (5%)
Query: 483 EGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVV 542
+G + + E R+L + E L +++ + + + L A V+ V
Sbjct: 191 DGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAV 250
Query: 543 EYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAE-LLVKHGAVVNVADLWKFTPLHEAAA 601
LL G V+ + G L ACS G+YE+A+ LL H V + TPL AA
Sbjct: 251 RKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAAN 310
Query: 602 KGKYEICKLLLQHGADPTKKNRDGNTPL---------DLVK---DGDTDIQD-LLRGDAA 648
G +I KLLL H AD ++ GNT L D+VK + I+D G
Sbjct: 311 GGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTP 370
Query: 649 LLDAAKKGCLARVK-KLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNA 707
L++A G + + L + +N + + S L LA +LE+ +LL+ GAD
Sbjct: 371 LMEAGSAGHVEVARLLLENGAGINTHSNEFKESA-LTLACYKGHLEMVRFLLEAGADQEH 429
Query: 708 QDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAH 767
+ L A GHV+VA LL+ A VN +PL AA G +L ALL+
Sbjct: 430 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 489
Query: 768 GADPTLKNQEGQTPL 782
GA N EG TPL
Sbjct: 490 GASLEEVNDEGYTPL 504
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 201 bits (510), Expect = 4e-51
Identities = 237/854 (27%), Positives = 353/854 (41%), Gaps = 111/854 (12%)
Query: 70 RKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLH 129
R+D + LL NGA+V D G L NA G +VVNLL+ GAD D +TPL
Sbjct: 524 REDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLT 583
Query: 130 EAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGN 189
AA +G V L+ GA + DG TAL A A G+
Sbjct: 584 LAARQGHTKVVNCLIGCGANINHTDQDGWTALRSA--------------------AWGGH 623
Query: 190 EEKMMALL-TPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPL 248
E + ALL + V+C +D R T L AA IV LLQHGA+V+ D L
Sbjct: 624 TEVVSALLYAGVKVDCADADSR--TALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTAL 681
Query: 249 HNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEA-----ASKNRVEVCSLLLSYGADP 303
A GH E+ E L+ HGA VN D+ T L A ASK V SLL+ GA+
Sbjct: 682 IAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAE- 740
Query: 304 TLLNCHNKSAIDLAPTPQLKERLAYEFKGH-----SLLQAAREADVTRIKKHLSLEMVNF 358
+D + L ++GH LL+ + D T
Sbjct: 741 ----------VDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHT------------- 777
Query: 359 KHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEV 418
T L AA+ + + LL GA ++ E T L +AS + + +VV
Sbjct: 778 --DNNGRTPLLAAASMGH---ASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRT 832
Query: 419 VVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQG----FTALQMGN 474
++ N D+ G T LH AA+ GH C L+ G N I G A Q G+
Sbjct: 833 LLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGH 892
Query: 475 ENVQQLLQE---GISLGNSEADRQLLEAAKAGDVETVKKLCT-VQSVNCRDIEGRQSTPL 530
+ Q+L E I + L AA G + V+ L + VNC+D +GR + L
Sbjct: 893 YDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPT--L 950
Query: 531 HFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADL 590
+ A N++++ EY L++GA+V A D G LH +C GH E+ ++L+ + A VN AD
Sbjct: 951 YILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADN 1010
Query: 591 WKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDL-VKDGDTDIQDLLR----- 644
K + L AA +G ++ +LL++HGA G T L + ++G D+ +L
Sbjct: 1011 EKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGAD 1070
Query: 645 -------GDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEY 697
G A+ AAK G +K L + G +P+H + +
Sbjct: 1071 PNHADQFGRTAMRVAAKNGHSQIIKLL---EKYGASSLNGCSPSPVH--------TMEQK 1119
Query: 698 LLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKY-NACVNATDKWAFTPLHEAAQKG 756
LQ ++++ + I +++ S G D+ L N +A + +P +
Sbjct: 1120 PLQ---SLSSKVQSLTIKSNSSGSTGGGDMQPSLRGLPNGPTHAFSSPSESP-DSTVDRQ 1175
Query: 757 RTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSAL-LTAAMPPSALPSCYKPQVLNGV 815
++ L L + +L+ V D L T + +LP Q +
Sbjct: 1176 KSSLSNNSLKSSKNSSLRTTSSTATAQTVPIDSFHNLSFTEQIQQHSLPRSRSRQ---SI 1232
Query: 816 RSPGATADALSSGPSSPSS----LSAASSLDNLSGSFSELSSVVSSSGTEG--ASSLEKK 869
SP +T +L +SPSS SL + S S + SG+ G A
Sbjct: 1233 VSPSSTTQSLGQSHNSPSSEFEWSQVKPSLKSTKASKGGKSENSAKSGSAGKKAKQSNSS 1292
Query: 870 EVPGVDFSITQFVR 883
+ +++ +TQF R
Sbjct: 1293 QPKVLEYEMTQFDR 1306
Score = 199 bits (505), Expect = 2e-50
Identities = 207/734 (28%), Positives = 317/734 (43%), Gaps = 79/734 (10%)
Query: 161 LDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAG 220
L+ A+ + + G +D L S E++++ LL + ++ D R S + A
Sbjct: 466 LETAELALWMIWNGTPVRDSL--STLIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQAL- 522
Query: 221 YNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTP 280
R ++ LL +GA V+ D L NA G +V LLV GA + D TP
Sbjct: 523 -EREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTP 581
Query: 281 LHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAR 340
L AA + +V + L+ GA+ + +A+ A E ++ +LL A
Sbjct: 582 LTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVS------ALLYAGV 635
Query: 341 EADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEF 400
+ D TAL AA + + I LL+ GA +N+ E
Sbjct: 636 KVDCADADSR---------------TALRAAA---WGGHEDIVLNLLQHGAEVNKADNEG 677
Query: 401 LTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYC-----GHLQTCRLLLSY 455
T L A+ H ++VE ++ H A+VN D G+T+L AA C GH LL+
Sbjct: 678 RTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDR 737
Query: 456 GCDPNIISLQGFTALQM----GNENVQQLLQEG---ISLGNSEADRQLLEAAKAGDVETV 508
G + + G T L + G+ +V LL EG + ++ LL AA G V
Sbjct: 738 GAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVV 797
Query: 509 KKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNAC 567
L +V+ D EGR T L A+ V VV LL G D + +D G PLH A
Sbjct: 798 NTLLFWGAAVDSIDSEGR--TVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAA 855
Query: 568 SYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNT 627
GH + E L++ GA N D P A+ +G Y+ ++LL++ ++ ++ DG
Sbjct: 856 FEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRN 915
Query: 628 PLDLVK-DGDTDIQDLLRGDAALLDAAKKG------CLARVKKLSSPD-------NVNCR 673
L + +G DI +LL A ++ LA +L+ + NV
Sbjct: 916 ALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEAS 975
Query: 674 DTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIK 733
D +GR T LH++ ++E+ + L+ + ADVNA D L +AA GHV V LLI+
Sbjct: 976 DAEGR--TALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIE 1033
Query: 734 YNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSAL 793
+ A V+ T T L AAQ+G + +LL HGADP +Q G+T + + + + S +
Sbjct: 1034 HGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQI 1093
Query: 794 LTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSS 853
+ L Y LNG SP SP L +LS L+
Sbjct: 1094 I-------KLLEKYGASSLNGC-SP------------SPVHTMEQKPLQSLSSKVQSLTI 1133
Query: 854 VVSSSGTEGASSLE 867
+SSG+ G ++
Sbjct: 1134 KSNSSGSTGGGDMQ 1147
Score = 196 bits (499), Expect = 8e-50
Identities = 182/623 (29%), Positives = 274/623 (43%), Gaps = 81/623 (13%)
Query: 28 LFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQA 86
L A +G ++ V LV+ + D G TPL AA G VV L+ GAN+
Sbjct: 549 LANAAYSGSLDVVNLLVSRGADLEIEDAHGH--TPLTLAARQGHTKVVNCLIGCGANINH 606
Query: 87 RDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 146
D G L +A GH EVV+ LL G + D + T L AA G D+ + LLQH
Sbjct: 607 TDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQH 666
Query: 147 GAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLT-PLNVNCH 205
GAE + +GRTA L+ +A G+ E + LL VN
Sbjct: 667 GAEVNKADNEGRTA--------------------LIAAAYMGHREIVEHLLDHGAEVNHE 706
Query: 206 ASDGRKS---TPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTEL 262
DGR + L + A +V LL+ GA+V DK + PL A GH +V +L
Sbjct: 707 DVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDL 766
Query: 263 LVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQL 322
L++ GA V+ D TPL AAS V + LL +GA ++ ++ + +
Sbjct: 767 LLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSI------ 820
Query: 323 KERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQI 382
A+ + +V ++ L + T LH AA + + I
Sbjct: 821 ---------------ASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAA---FEGHRLI 862
Query: 383 CELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAY 442
CE L+ +GA NE + P +AS++ H D V++++++++ ++ G+ +L AA
Sbjct: 863 CEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAAL 922
Query: 443 CGHLQTCRLLLSYGCDPNIISLQGFTALQ-MGNENVQQLLQEGISLGNSEADRQLLEAAK 501
GH LL S+G D N G L + EN QL L N
Sbjct: 923 EGHRDIVELLFSHGADVNCKDADGRPTLYILALEN--QLTMAEYFLENG----------- 969
Query: 502 AGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLV 561
+V D EGR T LH + + +V+ L+ + ADV+A D
Sbjct: 970 -------------ANVEASDAEGR--TALHVSCWQGHMEMVQVLIAYHADVNAADNEKRS 1014
Query: 562 PLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKK 621
L +A GH +V +LL++HGAVV+ T L AA +G ++ ++LL+HGADP
Sbjct: 1015 ALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHA 1074
Query: 622 NRDGNTPLDL-VKDGDTDIQDLL 643
++ G T + + K+G + I LL
Sbjct: 1075 DQFGRTAMRVAAKNGHSQIIKLL 1097
Score = 85.1 bits (209), Expect = 4e-16
Identities = 68/239 (28%), Positives = 105/239 (43%), Gaps = 58/239 (24%)
Query: 49 VNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVN 108
VN +D GR + L+ A + + EY L+NGANV+A D G LH +C GH E+V
Sbjct: 939 VNCKDADGRPT--LYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQ 996
Query: 109 LLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSA 168
+L+ + AD NA DN + L AA +G + V +L++HGA G TAL +A
Sbjct: 997 VLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIA---- 1052
Query: 169 KAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQ 228
A +G + +VQ
Sbjct: 1053 -------------------------------------AQEG-------------HIDVVQ 1062
Query: 229 LLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASK 287
+LL+HGAD + D+ + A GH ++ +LL K+GA ++++ +P+H K
Sbjct: 1063 VLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA--SSLNGCSPSPVHTMEQK 1119
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 166 bits (420), Expect = 1e-40
Identities = 130/400 (32%), Positives = 188/400 (47%), Gaps = 48/400 (12%)
Query: 385 LLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCG 444
LLL +++ +T TPL +A++ D+ +++ H A N +D G LH AA G
Sbjct: 380 LLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNG 439
Query: 445 HLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGD 504
T RLLL +G + +G+T L + +N N E +LL + +A
Sbjct: 440 DDGTARLLLDHGACVDAQEREGWTPLHLAAQN------------NFENVARLLVSRQADP 487
Query: 505 VETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLH 564
N + EG+ TPLH AA + VS+V+ L GA++ A+ + PLH
Sbjct: 488 -------------NLHEAEGK--TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLH 532
Query: 565 NACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRD 624
A G + L+K GAV + D + PLH AAA+GKY ICK+LL++GA
Sbjct: 533 LAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQ 592
Query: 625 GNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLH 684
G TPL L AA KG L + L + + N + TPLH
Sbjct: 593 GWTPLHL--------------------AAYKGHL-EIIHLLAESHANMGALGAVNWTPLH 631
Query: 685 LAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKW 744
LAA + V LLQ GAD NA ++ G PLH A L++++A V+A +K
Sbjct: 632 LAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKV 691
Query: 745 AFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDL 784
+TP H AA KG T + +L+ GA +++ TPL L
Sbjct: 692 GWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQL 731
Score = 147 bits (371), Expect = 6e-35
Identities = 129/466 (27%), Positives = 202/466 (43%), Gaps = 51/466 (10%)
Query: 19 EAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTA----GRKSTPLHFAAGFGRKDVV 74
E E ++EL ++ ++R +L + + RD K TPLHF G + V
Sbjct: 319 EVNEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQV 378
Query: 75 EYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIK 134
LL + +V + G PL A ++ LLL HGAD N D + PLH AA
Sbjct: 379 RLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQN 438
Query: 135 GKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMM 194
G +LL HGA + +G T L L A N E +
Sbjct: 439 GDDGTARLLLDHGACVDAQEREGWTPLHL---------------------AAQNNFENVA 477
Query: 195 ALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSY 254
LL + + + TPLH+AA + V +V+LL GA++ A+ + PLH A
Sbjct: 478 RLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVER 537
Query: 255 GHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAI 314
G + L+K GA +A+D + PLH AA++ + +C +LL YGA L + +
Sbjct: 538 GKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPL 597
Query: 315 DLAPTPQLKERLAYEFKGH-SLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAA 373
LA +KGH ++ E+ +L VN+ T LH AA
Sbjct: 598 HLA-----------AYKGHLEIIHLLAESHANM----GALGAVNW-------TPLHLAAR 635
Query: 374 SPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLG 433
+ + LL+ GA+ N + TPLH+A +++ V +++H A V+A + +G
Sbjct: 636 H---GEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVG 692
Query: 434 QTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQ 479
T H AA G+ ++L+ G ++ T LQ+ + +Q
Sbjct: 693 WTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQ 738
Score = 142 bits (359), Expect = 1e-33
Identities = 141/484 (29%), Positives = 206/484 (42%), Gaps = 75/484 (15%)
Query: 158 RTALDLAD-----PSAKAVLTGEYKKDELLESARSGNEEKMMALLT-PLNVNCHASDGRK 211
+ AL L+D P + + E K L G+ E++ LL ++V+C + G
Sbjct: 338 KRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGY- 396
Query: 212 STPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVN 271
TPL +AA + + LLL HGAD + D+ PLH A G LL+ HGACV+
Sbjct: 397 -TPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVD 455
Query: 272 AMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFK 331
A + +TPLH AA N V LL+S
Sbjct: 456 AQEREGWTPLHLAAQNNFENVARLLVS--------------------------------- 482
Query: 332 GHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGA 391
R+AD H +T LH AA Y + +LL +GA
Sbjct: 483 --------RQADPNL-------------HEAEGKTPLHVAA---YFGHVSLVKLLTSQGA 518
Query: 392 NINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRL 451
++ + + TPLH+A E+ ++ ++K A +ALD G LH AA G C++
Sbjct: 519 ELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKM 578
Query: 452 LLSYGCDPNIISLQGFTALQM----GNENVQQLLQEG-ISLGNSEADR--QLLEAAKAGD 504
LL YG + + QG+T L + G+ + LL E ++G A L AA+ G+
Sbjct: 579 LLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGE 638
Query: 505 VETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLH 564
V L + E TPLH A + V LL+H A+VHA++K G P H
Sbjct: 639 EAVVSALLQC-GADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAH 697
Query: 565 NACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRD 624
A G+ + ++LV+ GA ++V D TPL A K I L G +P+
Sbjct: 698 LAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLG 755
Query: 625 GNTP 628
G+ P
Sbjct: 756 GSKP 759
Score = 130 bits (327), Expect = 7e-30
Identities = 101/306 (33%), Positives = 139/306 (45%), Gaps = 30/306 (9%)
Query: 503 GDVETVKKLCTVQ-SVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLV 561
G VE V+ L + V+C+ G TPL AA + + LL HGAD + D+ G
Sbjct: 373 GSVEQVRLLLAHEVDVDCQTASGY--TPLLIAAQDQQPDLCALLLAHGADANRVDEDGWA 430
Query: 562 PLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKK 621
PLH A G A LL+ HGA V+ + +TPLH AA + +LL+ ADP
Sbjct: 431 PLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLH 490
Query: 622 NRDGNTPLDLVKD-GDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHS 680
+G TPL + G + LL A LDA ++ N R
Sbjct: 491 EAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQR---------------NLR------- 528
Query: 681 TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNA 740
TPLHLA + ++LL+ GA +A D+ G PLH AA+ G + +L++Y A +
Sbjct: 529 TPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLEL 588
Query: 741 TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADD----VSALLTA 796
+TPLH AA KG ++ LL A+ TPL L + VSALL
Sbjct: 589 PTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQC 648
Query: 797 AMPPSA 802
P+A
Sbjct: 649 GADPNA 654
Score = 129 bits (323), Expect = 2e-29
Identities = 94/302 (31%), Positives = 142/302 (47%), Gaps = 25/302 (8%)
Query: 489 NSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIE----GRQSTPLHFAAGYNRVSVVEY 544
N + ++L+++ ++ +L +++ RD E + TPLHF V V
Sbjct: 321 NEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRL 380
Query: 545 LLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGK 604
LL H DV + G PL A ++ LL+ HGA N D + PLH AA G
Sbjct: 381 LLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGD 440
Query: 605 YEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKL 664
+LLL HGA + R+G TPL L Q+ A LL V +
Sbjct: 441 DGTARLLLDHGACVDAQEREGWTPLHLAA------QNNFENVARLL----------VSRQ 484
Query: 665 SSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGH 724
+ P N + +G+ TPLH+AA + ++ + + L GA+++AQ + PLH A G
Sbjct: 485 ADP---NLHEAEGK--TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
Query: 725 VDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDL 784
V L+K A +A D+ + PLH AA +G+ +C +LL +GA L +G TPL L
Sbjct: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
Query: 785 VS 786
+
Sbjct: 600 AA 601
Score = 119 bits (298), Expect = 2e-26
Identities = 90/286 (31%), Positives = 126/286 (44%), Gaps = 21/286 (7%)
Query: 16 AAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVE 75
A +A E + E V RL+ + + TPLH AA FG +V+
Sbjct: 452 ACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVK 511
Query: 76 YLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKG 135
L GA + A+ PLH A G + LL+ GA P+A D Y PLH AA +G
Sbjct: 512 LLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARG 571
Query: 136 KIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMA 195
K +C +LL++GA + G T L LA A G+ E ++
Sbjct: 572 KYLICKMLLRYGASLELPTHQGWTPLHLA--------------------AYKGHLE-IIH 610
Query: 196 LLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYG 255
LL + N A TPLHLAA + +V LLQ GAD +A ++ PLH A
Sbjct: 611 LLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRS 670
Query: 256 HYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGA 301
+ L++H A V+A + +TP H AA K + +L+ GA
Sbjct: 671 TFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGA 716
Score = 107 bits (267), Expect = 7e-23
Identities = 79/229 (34%), Positives = 103/229 (44%), Gaps = 23/229 (10%)
Query: 560 LVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPT 619
+ PLH + G E LL+ H V+ +TPL AA + ++C LLL HGAD
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
Query: 620 KKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRH 679
+ + DG PL D G A LL D+ C D Q R
Sbjct: 423 RVDEDGWAPLHFAAQNGDD------GTARLL----------------LDHGACVDAQERE 460
Query: 680 S-TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACV 738
TPLHLAA N VA L+ AD N + G PLH AA +GHV + LL A +
Sbjct: 461 GWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAEL 520
Query: 739 NATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSA 787
+A + TPLH A ++G+ + LL GA P +Q G PL +A
Sbjct: 521 DAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAA 569
Score = 78.2 bits (191), Expect = 4e-14
Identities = 53/166 (31%), Positives = 77/166 (46%), Gaps = 4/166 (2%)
Query: 649 LLDAAKKGCLARVKKLSSPDNVNCRDTQ----GRHSTPLHLAAGYNNLEVAEYLLQHGAD 704
L+D+ L R +LS N+ RD + TPLH ++E LL H D
Sbjct: 328 LMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVD 387
Query: 705 VNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALL 764
V+ Q G PL AA D+ ALL+ + A N D+ + PLH AAQ G LL
Sbjct: 388 VDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLL 447
Query: 765 LAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPSCYKPQ 810
L HGA + +EG TPL L + ++ + + A P+ ++ +
Sbjct: 448 LDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAE 493
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 164 bits (414), Expect = 6e-40
Identities = 169/572 (29%), Positives = 245/572 (42%), Gaps = 80/572 (13%)
Query: 14 ASAAAEAVEPAARELFEACRNGDVERVKR-LVTPEKVNSRDTAGRKSTPLHFAAGFGRKD 72
A + A A + R L EAC GDV V++ L+ VN G L +AG+ +
Sbjct: 224 AESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGY--YE 281
Query: 73 VVEYLLQNGANVQARD-DGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEA 131
+ + LL ANV+ R G + PL A + GH ++V LLL H AD NA+ + T L A
Sbjct: 282 LAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYA 341
Query: 132 AIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEE 191
G +DV VLL+ GA N +G T L+E+ +G+ E
Sbjct: 342 CAGGYVDVVKVLLESGASIEDHNENGHT--------------------PLMEAGSAGHVE 381
Query: 192 KMMALL-TPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHN 250
LL +N H+++ ++S L LA +++V+ LL+ GAD K L
Sbjct: 382 VARLLLENGAGINTHSNEFKESA-LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALME 440
Query: 251 ACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHN 310
AC GH EV LL+ GA VN +PL AA VE+ +LL+ GA +N
Sbjct: 441 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVN--- 497
Query: 311 KSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSL-EMVNFKHPQTHETALH 369
D TP L++AARE + L +N + +T ETAL
Sbjct: 498 ----DEGYTP--------------LMEAAREGHEEMVALLLGQGANINAQTEETQETALT 539
Query: 370 CAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNAL 429
A + ++ + L++ GA+I TPL A+++ H ++V+ ++ A V+A
Sbjct: 540 LACCGGF---LEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHAT 593
Query: 430 DNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGN 489
G T+L A GH +LL G D S G T
Sbjct: 594 TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRT--------------------- 632
Query: 490 SEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHG 549
L++AA+AG V TV+ L + + R T L A ++VVE LL HG
Sbjct: 633 -----PLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHG 687
Query: 550 ADVHAKDKGGLVPLHNACSYGHYEVAELLVKH 581
AD + K G L A GH V L+ +
Sbjct: 688 ADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
Score = 162 bits (409), Expect = 2e-39
Identities = 185/700 (26%), Positives = 291/700 (41%), Gaps = 121/700 (17%)
Query: 301 ADPTLLNCHNKS---AIDLAPTPQLKERL-----AYEFKGHSLLQAAREADVTRIKKHLS 352
ADP +L S A+D A + R A + SL +A E DV ++K L
Sbjct: 196 ADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLI 255
Query: 353 LEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEK-TKEFLTPLHVASEKA 411
+H + E+ L A ++ Y ++ ++LL AN+ ++ K +TPL A+
Sbjct: 256 EGRSVNEHTEEGESLLCLACSAGY---YELAQVLLAMHANVEDRGIKGDITPLMAAANGG 312
Query: 412 HNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQ 471
H +V++++ H+A VNA + G T+L A G++ ++LL G +++
Sbjct: 313 HVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGA-----------SIE 361
Query: 472 MGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLH 531
NEN L E S G+ E R LLE +N E ++S L
Sbjct: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAG--------------INTHSNEFKESA-LT 406
Query: 532 FAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV-ADL 590
A + +V +LL+ GAD K L AC GH EVA LL+ GA VN+ AD
Sbjct: 407 LACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 466
Query: 591 WKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPL-DLVKDGDTDIQDLLRGDAA- 648
++ +PL AA G E+ LL++ GA + N +G TPL + ++G ++ LL G A
Sbjct: 467 FE-SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGAN 525
Query: 649 ------------------------------------------LLDAAKKGCLARVKKLSS 666
L++AA++G L VK L +
Sbjct: 526 INAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLA 585
Query: 667 PDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVD 726
N T T L A + +VA+ LLQ GAD+ + +GG PL AA GHV
Sbjct: 586 A-GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVC 644
Query: 727 VAALLIKYNACVNATD-KWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQT----- 780
LI A VN T T L A G + LLLAHGADPT + ++G T
Sbjct: 645 TVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEA 704
Query: 781 ---------------PLDLVSA--DDVSALLTAA--------MPPSALPSCYKPQVLNGV 815
P +L+SA DV+ L + +P ALP PQ +
Sbjct: 705 AKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPD-- 762
Query: 816 RSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSSGTEGASSLEKKEVPGVD 875
+ P A L P + S S +L + ++ +++ E + ++ ++
Sbjct: 763 KPPANVATTL---PIRNKAASKQKSSSHLPANSQDVQGYITNQSPESIVEEAQGKLTELE 819
Query: 876 FSITQFVRNLGLEHLMDIFEREQITLDVLVEMGHKELKEI 915
I + + +++ +Q+T + + E+ ++I
Sbjct: 820 QRIKEAIEKNAQLQSLELAHADQLTKEKIEELNKTREEQI 859
Score = 156 bits (394), Expect = 1e-37
Identities = 168/561 (29%), Positives = 244/561 (43%), Gaps = 76/561 (13%)
Query: 98 ACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDG 157
+C+ A +R + NA + N + L EA +G ++ LL G +G
Sbjct: 209 SCALDEAAAALTRMRAESTANAGQSDNRS-LAEACSEGDVNAVRKLLIEGRSVNEHTEEG 267
Query: 158 RTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKS--TPL 215
+ L LA + G Y+ ++L + + E++ G K TPL
Sbjct: 268 ESLLCLACSA------GYYELAQVLLAMHANVEDR----------------GIKGDITPL 305
Query: 216 HLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDL 275
AA VKIV+LLL H ADV+A+ L AC+ G+ +V ++L++ GA + +
Sbjct: 306 MAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNE 365
Query: 276 WQFTPLHEAASKNRVEVCSLLLSYGAD-PTLLNCHNKSAIDLAPTPQLKERLAYEFKGHS 334
TPL EA S VEV LLL GA T N +SA+ LA +KGH
Sbjct: 366 NGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLAC-----------YKGH- 413
Query: 335 LLQAAREADVTRIKKHLSLEMVNF----KHPQTHET-ALHCAAASP-YPKRKQICELLLR 388
LEMV F Q H+T +H A ++ LLL
Sbjct: 414 ------------------LEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 455
Query: 389 KGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQT 448
GA +N F +PL +A+ H ++ ++++ A + +++ G T L AA GH +
Sbjct: 456 SGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEM 515
Query: 449 CRLLLSYGCDPNIISLQ-GFTALQMG-----NENVQQLLQEG--ISLGNSEADRQLLEAA 500
LLL G + N + + TAL + E L++ G I LG S L+EAA
Sbjct: 516 VALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAA 572
Query: 501 KAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGL 560
+ G +E VK L N T L +A V + LLQ GAD+ + +GG
Sbjct: 573 QEGHLELVKYLLAA-GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGR 631
Query: 561 VPLHNACSYGHYEVAELLVKHGAVVNVADLWK-FTPLHEAAAKGKYEICKLLLQHGADPT 619
PL A GH + L+ GA VN T L A A G + +LLL HGADPT
Sbjct: 632 TPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPT 691
Query: 620 KKNRDGNTPL-DLVKDGDTDI 639
+ +DG+T L + K G T +
Sbjct: 692 HRLKDGSTMLIEAAKGGHTSV 712
Score = 143 bits (360), Expect = 1e-33
Identities = 245/950 (25%), Positives = 369/950 (38%), Gaps = 192/950 (20%)
Query: 28 LFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQAR 87
L EAC +G VE V RL+ A +PL AA G ++ L++ GA+++
Sbjct: 438 LMEACMDGHVE-VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEV 496
Query: 88 DDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNY---------------------- 125
+D G PL A GH E+V LLL GA+ NA+
Sbjct: 497 NDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKA 556
Query: 126 ---------TPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTAL---------DLADPS 167
TPL EAA +G +++ LL GA G TAL D+AD
Sbjct: 557 GADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVL 616
Query: 168 AKAVLTGEYKKD----ELLESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLHLAAGYN 222
+A E++ + L+++AR+G+ + L++ NVN + T L LA
Sbjct: 617 LQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVN-RTTANNDHTVLSLACAGG 675
Query: 223 RVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHG---ACVNAMDLWQFT 279
+ +V+LLL HGAD + K L A GH V L+ + D+ Q T
Sbjct: 676 HLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLT 735
Query: 280 -PLHEAASKNRVEVCSL-LLSYGADP--------TLLNCHNKSA---------------I 314
P H+ RV V +L ++ +P T L NK+A +
Sbjct: 736 PPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAASKQKSSSHLPANSQDV 795
Query: 315 DLAPTPQLKERLAYEFKGH--SLLQAAREADVTRIKKHLSLEMVNFKHPQ--THE--TAL 368
T Q E + E +G L Q +EA I+K+ L+ + H T E L
Sbjct: 796 QGYITNQSPESIVEEAQGKLTELEQRIKEA----IEKNAQLQSLELAHADQLTKEKIEEL 851
Query: 369 HCAAASPYPKRKQICELLLRKGANINEKTKE----------------------------F 400
+ K+++I E L + + KT++
Sbjct: 852 NKTREEQIQKKQKILEELQKVERELQLKTQQQLKKQYLEVKAQRIQLQQQQQQSCQHLGL 911
Query: 401 LTPLHVASEKAHND------VVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLS 454
LTP+ V + + D V V++K E + A +G + A L L
Sbjct: 912 LTPVGVGEQLSEGDYARLQQVDPVLLKDEPQQTAA-QMGFAPIQPLAMPQALPLAAGPLP 970
Query: 455 YGCDPNIISLQGFTALQMGNENVQQLLQEGISLG-NSEADRQLLEAAKAGDVETVKKLCT 513
G N+ LQG + +G + Q G+ G +E + L+ A+ A + L
Sbjct: 971 PGSIANLTELQG---VIVGQPVLGQAQLAGLGQGILTETQQGLMVASPAQTLNDT--LDD 1025
Query: 514 VQSVNCRDIEGRQSTPLH-FAAGYNR---------VSVVEYL-LQHGADVHAKDKGGL-V 561
+ + +TP H AA ++ +S L + D+ A+ +
Sbjct: 1026 IMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDT 1085
Query: 562 PLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGAD-PTK 620
L AC+ GH E+ + L++ GA + D FTPL AA G + ++LL +GAD +
Sbjct: 1086 ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 1145
Query: 621 KNRDGNTPLDLV-KDGDTDIQDLL--RG---------DAALLDAAKKGCLARVKK--LSS 666
R +TPL L G ++ +LL RG D L A G + K L++
Sbjct: 1146 SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1205
Query: 667 PDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQ------------------ 708
+N R +PL LAA + + LL G+D+NAQ
Sbjct: 1206 GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1265
Query: 709 ----------------DKGGLIPLHNAASYGHVDVAALLIKYNACVNA--TDKWAFTPLH 750
K GL PL AAS G+ +V +L+ A VNA T L
Sbjct: 1266 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1325
Query: 751 EAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSAD---DVSALLTAA 797
AA KG + C LL+ GA ++N++G TPL L + DV LL A
Sbjct: 1326 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQA 1375
Score = 142 bits (358), Expect = 2e-33
Identities = 170/580 (29%), Positives = 244/580 (42%), Gaps = 91/580 (15%)
Query: 182 LESARSGNEEKMMALLTPLNVNCHASDGRKST-PLHLAAGYNRVKIVQLLLQHGADV--H 238
L S+ S ++ A LT + A+ G+ L A V V+ LL G V H
Sbjct: 204 LTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEH 263
Query: 239 AKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDL-WQFTPLHEAASKNRVEVCSLLL 297
++ L+ L ACS G+YE+ ++L+ A V + TPL AA+ V++ LLL
Sbjct: 264 TEEGESLLCL--ACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLL 321
Query: 298 SYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVN 357
A +ADV
Sbjct: 322 -----------------------------------------AHKADVNA----------- 329
Query: 358 FKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVE 417
T TAL A A Y + ++LL GA+I + + TPL A H +V
Sbjct: 330 --QSSTGNTALTYACAGGYV---DVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVAR 384
Query: 418 VVVKHEAKVNALDN-LGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQM---- 472
+++++ A +N N +++L A Y GHL+ R LL G D + + TAL
Sbjct: 385 LLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMD 444
Query: 473 GNENVQQLLQEGISLGNSEADR---QLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTP 529
G+ V +LL + + N AD L AA G VE + L + + ++ TP
Sbjct: 445 GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE-LAALLIERGASLEEVNDEGYTP 503
Query: 530 LHFAAGYNRVSVVEYLLQHGADVHAK-DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVA 588
L AA +V LL GA+++A+ ++ L AC G EVA+ L+K GA +
Sbjct: 504 LMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADI--- 560
Query: 589 DLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV-KDGDTDIQDLLR--- 644
+L TPL EAA +G E+ K LL GA+ G+T L ++G TD+ D+L
Sbjct: 561 ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAG 620
Query: 645 ---------GDAALLDAAKKGCLARVKKLSSPD-NVNCRDTQGRHSTPLHLAAGYNNLEV 694
G L+ AA+ G + V+ L S NVN R T T L LA +L V
Sbjct: 621 ADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVN-RTTANNDHTVLSLACAGGHLAV 679
Query: 695 AEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKY 734
E LL HGAD + K G L AA GH V L+ Y
Sbjct: 680 VELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
Score = 118 bits (296), Expect = 3e-26
Identities = 107/350 (30%), Positives = 161/350 (46%), Gaps = 38/350 (10%)
Query: 364 HETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHE 423
H+TAL A A + +++ + LL +GA+I + K+ TPL +A+ H VVE+++ +
Sbjct: 1083 HDTALTLACAGGH---EELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 1139
Query: 424 AKVNA-LDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN-----V 477
A + A + T L A G + LLL+ G + ++ +T L + +
Sbjct: 1140 ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 1199
Query: 478 QQLLQEGISLGNSEADR----QLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFA 533
+ LL G + + + L+ AA G VK L + S IE ++T L A
Sbjct: 1200 KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLA 1259
Query: 534 AGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADL--W 591
R VV LL A+V + K GL PL A S G+ EV +L+ GA VN +
Sbjct: 1260 CFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1319
Query: 592 KFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKD-GDTDIQDLLRGDAALL 650
+ T L AA KG Y+ C+LL+ GA +N+ GNTPL L + G D+ LL A +
Sbjct: 1320 RDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADV 1379
Query: 651 DAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQ 700
DAA DN R TPL A +++V YL++
Sbjct: 1380 DAA--------------DN--------RKITPLMAAFRKGHVKVVRYLVK 1407
Score = 109 bits (273), Expect = 1e-23
Identities = 103/374 (27%), Positives = 158/374 (42%), Gaps = 67/374 (17%)
Query: 251 ACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHN 310
AC+ GH E+ + L++ GA + D FTPL AA+ V V +LL GAD
Sbjct: 1090 ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGAD-------- 1141
Query: 311 KSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHC 370
+ + +T +T L
Sbjct: 1142 ---------------------------------------------IEAQSERTKDTPLSL 1156
Query: 371 AAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNAL- 429
A + R+++ ELLL +GAN + TPL +A+ + +++++++ A++N+
Sbjct: 1157 ACSGG---RQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 1213
Query: 430 -DNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI-ISLQGFTALQM----GNENVQQLLQE 483
LG + L AA GH +LLL G D N I TAL + G V LL +
Sbjct: 1214 GSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLD 1273
Query: 484 GISLGNSEADR---QLLEAAKAGDVETVKKLCTVQS-VNCRDIEGRQSTPLHFAAGYNRV 539
+ A L+EAA G E + L + VN + + T L AA
Sbjct: 1274 RKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHY 1333
Query: 540 SVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEA 599
E L+ GA + ++K G PL A + GH +V +LLV+ GA V+ AD K TPL A
Sbjct: 1334 KFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAA 1393
Query: 600 AAKGKYEICKLLLQ 613
KG ++ + L++
Sbjct: 1394 FRKGHVKVVRYLVK 1407
Score = 108 bits (271), Expect = 2e-23
Identities = 130/437 (29%), Positives = 182/437 (41%), Gaps = 65/437 (14%)
Query: 31 ACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDD 89
AC G E V+ L+ + RD G TPL AA G VVE LL NGA+++A+ +
Sbjct: 1090 ACAGGHEELVQTLLERGASIEHRDKKG--FTPLILAATAGHVGVVEILLDNGADIEAQSE 1147
Query: 90 GGL-IPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGA 148
PL ACS G EVV LLL GA+ R+ +YTPL AA G +++ +LL GA
Sbjct: 1148 RTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGA 1207
Query: 149 EPTIRN-------------TDGRTA-----LDL-ADPSAK-----------AVLTGEYKK 178
E R +G TA LD+ +D +A+ A G +
Sbjct: 1208 EINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEV 1267
Query: 179 DELLESARSGNEEKMMALLTPL--------------------NVNCHASDGRKSTPLHLA 218
LL ++ E + LTPL +VN + T L +A
Sbjct: 1268 VSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIA 1327
Query: 219 AGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQF 278
A K +LL+ GA + ++K PL A + GH +V +LLV+ GA V+A D +
Sbjct: 1328 ADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKI 1387
Query: 279 TPLHEAASKNRVEVCSLLL-SYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQ 337
TPL A K V+V L+ P+ C A K L E S++Q
Sbjct: 1388 TPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCME----SIVQ 1443
Query: 338 AAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQ----ICELLLRKGANI 393
A++ K+ S+ + + E + A A+ KRK+ E RK I
Sbjct: 1444 -AKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEI 1502
Query: 394 NEKTKEFLTPLHVASEK 410
K KE L A EK
Sbjct: 1503 EAKNKENF-ELQAAQEK 1518
Score = 108 bits (269), Expect = 4e-23
Identities = 131/462 (28%), Positives = 191/462 (41%), Gaps = 74/462 (16%)
Query: 54 TAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRH 113
T T L A G +++V+ LL+ GA+++ RD G PL A + GH VV +LL +
Sbjct: 1079 TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 1138
Query: 114 GADPNAR-DNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVL 172
GAD A+ + TPL A G+ +V +LL GA RN T L L
Sbjct: 1139 GADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSL--------- 1189
Query: 173 TGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRK--STPLHLAAGYNRVKIVQLL 230
A SG ++ +L ++ G K +PL LAA V+LL
Sbjct: 1190 ------------AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLL 1237
Query: 231 LQHGADVHAK-DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNR 289
L G+D++A+ + L AC G EV LL+ A V TPL EAAS
Sbjct: 1238 LDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGY 1297
Query: 290 VEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKE---RLAYEFKGH-----SLLQAARE 341
EV +LL GAD ++ P P ++ +A + KGH L+
Sbjct: 1298 AEVGRVLLDKGAD-----------VNAPPVPSSRDTALTIAAD-KGHYKFCELLIGRGAH 1345
Query: 342 ADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFL 401
DV K + T L AA + + +LL++ GA+++ +
Sbjct: 1346 IDVRNKKGN---------------TPLWLAANGGH---LDVVQLLVQAGADVDAADNRKI 1387
Query: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGH--LQTCRLLLSYGCDP 459
TPL A K H VV +VK +VN + + + A L+ C L C
Sbjct: 1388 TPLMAAFRKGHVKVVRYLVK---EVNQFPSDSECMRYIATITDKEMLKKCHL-----CME 1439
Query: 460 NIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAK 501
+I+ + A + N+N LL+E E R+L AAK
Sbjct: 1440 SIVQAKDRQAAE-ANKNASILLEELDLEKLREESRRLALAAK 1480
Score = 104 bits (259), Expect = 6e-22
Identities = 101/315 (32%), Positives = 145/315 (46%), Gaps = 29/315 (9%)
Query: 475 ENVQQLLQEGISLGNSEAD--RQLLEAAKAGDVETVKKLCTVQSVNCRDIEGR----QST 528
E VQ LL+ G S+ + + L+ AA AG V V+ L N DIE + + T
Sbjct: 1097 ELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD----NGADIEAQSERTKDT 1152
Query: 529 PLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVA 588
PL A R VVE LL GA+ ++ PL A S G+ + ++L+ GA +N
Sbjct: 1153 PLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSR 1212
Query: 589 DLWKF--TPLHEAAAKGKYEICKLLLQHGADPTKK-NRDGNTPLDLVK-DGDTDIQDLL- 643
K +PL AA G KLLL G+D + + NT L L G T++ LL
Sbjct: 1213 TGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLL 1272
Query: 644 -----------RGDAALLDAAKKGCLARVKK--LSSPDNVNCRDTQGRHSTPLHLAAGYN 690
G L++AA G A V + L +VN T L +AA
Sbjct: 1273 DRKANVEHRAKTGLTPLMEAASGG-YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1331
Query: 691 NLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLH 750
+ + E L+ GA ++ ++K G PL AA+ GH+DV LL++ A V+A D TPL
Sbjct: 1332 HYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLM 1391
Query: 751 EAAQKGRTQLCALLL 765
A +KG ++ L+
Sbjct: 1392 AAFRKGHVKVVRYLV 1406
Score = 98.2 bits (243), Expect = 4e-20
Identities = 96/315 (30%), Positives = 138/315 (43%), Gaps = 16/315 (5%)
Query: 483 EGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVV 542
+G + + E R+L + E L +++ + + + L A V+ V
Sbjct: 191 DGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAV 250
Query: 543 EYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAE-LLVKHGAVVNVADLWKFTPLHEAAA 601
LL G V+ + G L ACS G+YE+A+ LL H V + TPL AA
Sbjct: 251 RKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAAN 310
Query: 602 KGKYEICKLLLQHGADPTKKNRDGNTPL---------DLVK---DGDTDIQD-LLRGDAA 648
G +I KLLL H AD ++ GNT L D+VK + I+D G
Sbjct: 311 GGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTP 370
Query: 649 LLDAAKKGCLARVK-KLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNA 707
L++A G + + L + +N + + S L LA +LE+ +LL+ GAD
Sbjct: 371 LMEAGSAGHVEVARLLLENGAGINTHSNEFKESA-LTLACYKGHLEMVRFLLEAGADQEH 429
Query: 708 QDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAH 767
+ L A GHV+VA LL+ A VN +PL AA G +L ALL+
Sbjct: 430 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 489
Query: 768 GADPTLKNQEGQTPL 782
GA N EG TPL
Sbjct: 490 GASLEEVNDEGYTPL 504
Score = 80.5 bits (197), Expect = 9e-15
Identities = 70/211 (33%), Positives = 92/211 (43%), Gaps = 31/211 (14%)
Query: 28 LFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQAR 87
L A NG VK L+ + ++T L A GR +VV LL ANV+ R
Sbjct: 1222 LMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHR 1281
Query: 88 DDGGLIPLHNACSFGHAEVVNLLLRHGAD------PNARDNWNYTPLHEAAIKGKIDVCI 141
GL PL A S G+AEV +LL GAD P++RD T L AA KG C
Sbjct: 1282 AKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD----TALTIAADKGHYKFCE 1337
Query: 142 VLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLN 201
+L+ GA +RN G T L L A +G ++ LL
Sbjct: 1338 LLIGRGAHIDVRNKKGNTPLWL---------------------AANGGHLDVVQLLVQAG 1376
Query: 202 VNCHASDGRKSTPLHLAAGYNRVKIVQLLLQ 232
+ A+D RK TPL A VK+V+ L++
Sbjct: 1377 ADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 159 bits (403), Expect = 1e-38
Identities = 164/560 (29%), Positives = 242/560 (43%), Gaps = 80/560 (14%)
Query: 26 RELFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANV 84
R L EAC +GDV V++L+ VN G L +AG+ ++ + LL ANV
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGY--YELAQVLLAMHANV 264
Query: 85 QAR-DDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVL 143
+ R + G + PL A S G+ ++V LLL H AD N++ T L A G +D+ VL
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 144 LQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLT-PLNV 202
L GA N +G T L+E+A +G+ E LL +
Sbjct: 325 LNEGANIEDHNENGHT--------------------PLMEAASAGHVEVARVLLDHGAGI 364
Query: 203 NCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTEL 262
N H+++ ++S L LA + +V+ LL+ GAD K L AC GH EV L
Sbjct: 365 NTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 423
Query: 263 LVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQL 322
L+ GA VN +PL AA VE+ +LL+ GA+ +N D TP
Sbjct: 424 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN-------DEGYTP-- 474
Query: 323 KERLAYEFKGHSLLQAAREADVTRIKKHLSL-EMVNFKHPQTHETALHCAAASPYPKRKQ 381
L++AARE + L+ +N + +T ETAL A + +
Sbjct: 475 ------------LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGF---SE 519
Query: 382 ICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAA 441
+ + L++ GA+I TPL AS++ H ++V+ ++ A V+A G T+L A
Sbjct: 520 VADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 576
Query: 442 YCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAK 501
GH +LL G D S G T L++AA+
Sbjct: 577 ENGHTDVADVLLQAGADLEHESEGGRT--------------------------PLMKAAR 610
Query: 502 AGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLV 561
AG + TV+ L + + R T + A ++VVE LL HGAD + K G
Sbjct: 611 AGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGST 670
Query: 562 PLHNACSYGHYEVAELLVKH 581
L A GH V L+ +
Sbjct: 671 MLIEAAKGGHTNVVSYLLDY 690
Score = 154 bits (389), Expect = 5e-37
Identities = 145/496 (29%), Positives = 221/496 (44%), Gaps = 78/496 (15%)
Query: 334 SLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANI 393
SL +A + DV ++K L +H + E+ L A ++ Y ++ ++LL AN+
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGY---YELAQVLLAMHANV 264
Query: 394 NEK-TKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLL 452
++ K +TPL AS + D+V++++ H+A VN+ G T+L A G + ++L
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 453 LSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLC 512
L+ G + ++ NEN L E S G+ E R LL+
Sbjct: 325 LNEGAN-----------IEDHNENGHTPLMEAASAGHVEVARVLLDHGAG---------- 363
Query: 513 TVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHY 572
+N E ++S L A + +V +LL+ GAD K L AC GH
Sbjct: 364 ----INTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 418
Query: 573 EVAELLVKHGAVVNV-ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPL-D 630
EVA LL+ GA VN+ AD ++ +PL AA G E+ LL++ GA+ + N +G TPL +
Sbjct: 419 EVARLLLDSGAQVNMPADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLME 477
Query: 631 LVKDGDTDIQDLLRGDAA------------------------------------------ 648
++G ++ LL A
Sbjct: 478 AAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCST 537
Query: 649 -LLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNA 707
L++A+++G L VK L + N T T L A + +VA+ LLQ GAD+
Sbjct: 538 PLMEASQEGHLELVKYLLA-SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
Query: 708 QDKGGLIPLHNAASYGHVDVAALLIKYNACVN-ATDKWAFTPLHEAAQKGRTQLCALLLA 766
+ +GG PL AA GH+ LI A VN AT T + A G + LLLA
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656
Query: 767 HGADPTLKNQEGQTPL 782
HGADPT + ++G T L
Sbjct: 657 HGADPTHRLKDGSTML 672
Score = 146 bits (369), Expect = 1e-34
Identities = 170/580 (29%), Positives = 241/580 (41%), Gaps = 90/580 (15%)
Query: 181 LLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADV--H 238
L S +E AL N H + + L A V V+ LL G V H
Sbjct: 175 LTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEH 234
Query: 239 AKDKGDLVPLHNACSYGHYEVTE-LLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLL 297
++ L+ L ACS G+YE+ + LL H + + TPL A+S +++ LLL
Sbjct: 235 TEEGESLLCL--ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL 292
Query: 298 SYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVN 357
+ +ADV
Sbjct: 293 LH-----------------------------------------DADVN------------ 299
Query: 358 FKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVE 417
T TAL A A + I ++LL +GANI + + TPL A+ H +V
Sbjct: 300 -SQSATGNTALTYACAGGFV---DIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 355
Query: 418 VVVKHEAKVNALDN-LGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQM---- 472
V++ H A +N N +++L A Y GHL R LL G D + + TAL
Sbjct: 356 VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 415
Query: 473 GNENVQQLLQEGISLGNSEADR---QLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTP 529
G+ V +LL + + N AD L AA G VE + L + N ++ TP
Sbjct: 416 GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE-LAALLIERGANLEEVNDEGYTP 474
Query: 530 LHFAAGYNRVSVVEYLLQHGADVHAK-DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVA 588
L AA +V LL GA+++A+ ++ L AC G EVA+ L+K GA +
Sbjct: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI--- 531
Query: 589 DLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV-KDGDTDIQDLLR--- 644
+L TPL EA+ +G E+ K LL GA+ G+T L ++G TD+ D+L
Sbjct: 532 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
Query: 645 ---------GDAALLDAAKKGCLARVKKLSSPD-NVNCRDTQGRHSTPLHLAAGYNNLEV 694
G L+ AA+ G L V+ L S NVN R T T + LA +L V
Sbjct: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVN-RATANNDHTVVSLACAGGHLAV 650
Query: 695 AEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKY 734
E LL HGAD + K G L AA GH +V + L+ Y
Sbjct: 651 VELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 120 bits (301), Expect = 8e-27
Identities = 106/302 (35%), Positives = 147/302 (48%), Gaps = 19/302 (6%)
Query: 494 RQLLEAAKAGDVETVKKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADV 552
R L EA GDV V+KL +SVN EG L +AGY ++ V LL A+V
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV--LLAMHANV 264
Query: 553 HAK-DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLL 611
+ +KG + PL A S G+ ++ +LL+ H A VN T L A A G +I K+L
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 612 LQHGADPTKKNRDGNTPL-DLVKDGDTDIQDLLRG-------------DAALLDAAKKGC 657
L GA+ N +G+TPL + G ++ +L ++AL A KG
Sbjct: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 384
Query: 658 LARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLH 717
L V+ L T H T L A ++EVA LL GA VN PL
Sbjct: 385 LDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443
Query: 718 NAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQE 777
AA GHV++AALLI+ A + + +TPL EAA++G ++ ALLLA GA+ + +E
Sbjct: 444 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503
Query: 778 GQ 779
Q
Sbjct: 504 TQ 505
Score = 119 bits (297), Expect = 2e-26
Identities = 118/404 (29%), Positives = 166/404 (41%), Gaps = 80/404 (19%)
Query: 54 TAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRH 113
T T L A G +++V L+ A ++ RD G PL A + GH VV +LL
Sbjct: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110
Query: 114 GADPNAR-DNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVL 172
G D A+ + TPL A G+ +V +LL GA RN T L L
Sbjct: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSL--------- 1161
Query: 173 TGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRK--STPLHLAAGYNRVKIVQLL 230
A SG ++ +L ++ G K +PL LAA V V+LL
Sbjct: 1162 ------------AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLL 1209
Query: 231 LQHGADVHAK-DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNR 289
L G+D++A+ + L AC G EV LL+ A V TPL EAAS
Sbjct: 1210 LDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGY 1269
Query: 290 VEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKK 349
EV +LL GAD ++ P P
Sbjct: 1270 AEVGRVLLDKGAD-----------VNAPPVP----------------------------- 1289
Query: 350 HLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASE 409
+ +TAL AA + K CELL+ +GA+I+ + K+ TPL +AS
Sbjct: 1290 ------------SSRDTALTIAADKGHYK---FCELLIHRGAHIDVRNKKGNTPLWLASN 1334
Query: 410 KAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLL 453
H DVV+++V+ A V+A DN T L A GH++ + L+
Sbjct: 1335 GGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
Score = 113 bits (283), Expect = 9e-25
Identities = 105/364 (28%), Positives = 169/364 (46%), Gaps = 35/364 (9%)
Query: 166 PSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVK 225
PS E D L A +G E+++++L + D + TPL LAA V
Sbjct: 1043 PSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVG 1102
Query: 226 IVQLLLQHGADVHAK-DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEA 284
+V++LL G D+ A+ ++ PL ACS G EV +LL+ GA ++ +TPL A
Sbjct: 1103 VVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162
Query: 285 ASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADV 344
AS V + +LL+ GA+ +N S + ++P L+ AA V
Sbjct: 1163 ASGGYVNIIKILLNAGAE---INSRTGSKLGISP----------------LMLAAMNGHV 1203
Query: 345 TRIKKHLSL-EMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTP 403
+K L + +N + TAL A + R ++ LLL + AN+ + K LTP
Sbjct: 1204 PAVKLLLDMGSDINAQIETNRNTALTLAC---FQGRAEVVSLLLDRKANVEHRAKTGLTP 1260
Query: 404 LHVASEKAHNDVVEVVVKHEAKVNA--LDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
L A+ + +V V++ A VNA + + T+L AA GH + C LL+ G ++
Sbjct: 1261 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV 1320
Query: 462 ISLQGFTALQMGNEN-----VQQLLQEG--ISLGNSEADRQLLEAAKAGDVETVKKLCTV 514
+ +G T L + + VQ L+Q G + ++ L+ A + G V+ V+ L V
Sbjct: 1321 RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYL--V 1378
Query: 515 QSVN 518
+ VN
Sbjct: 1379 KEVN 1382
Score = 111 bits (277), Expect = 5e-24
Identities = 116/404 (28%), Positives = 169/404 (41%), Gaps = 60/404 (14%)
Query: 31 ACRNGDVERVKRLVTPE-KVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDD 89
AC G E V L+ + K+ RD G TPL AA G VVE LL G +++A+ +
Sbjct: 1062 ACAGGHEELVSVLIARDAKIEHRDKKG--FTPLILAATAGHVGVVEILLDKGGDIEAQSE 1119
Query: 90 GGL-IPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGA 148
PL ACS G EVV+LLL GA+ R+ +YTPL AA G +++ +LL GA
Sbjct: 1120 RTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGA 1179
Query: 149 E-----------------------PTIR-------------NTDGRTALDLA-------- 164
E P ++ T+ TAL LA
Sbjct: 1180 EINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEV 1239
Query: 165 -----DPSAKAVLTGEYKKDELLESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLHLA 218
D A + L+E+A G E LL +VN + T L +A
Sbjct: 1240 VSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIA 1299
Query: 219 AGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQF 278
A K +LL+ GA + ++K PL A + GH++V +LLV+ GA V+A D +
Sbjct: 1300 ADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKI 1359
Query: 279 TPLHEAASKNRVEVCSLLL-SYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQ 337
TPL A K V+V L+ P+ + C A T KE L + +
Sbjct: 1360 TPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIA-----TITDKELLKKCHQCVETIV 1414
Query: 338 AAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQ 381
A++ K+ S+ + ++ E + A A+ KRK+
Sbjct: 1415 KAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKE 1458
Score = 110 bits (275), Expect = 8e-24
Identities = 107/315 (33%), Positives = 142/315 (45%), Gaps = 27/315 (8%)
Query: 490 SEADRQLLEAAKAGDVETVKKLCTVQS-VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQH 548
S D L A G E V L + + RD +G TPL AA V VVE LL
Sbjct: 1053 SNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKG--FTPLILAATAGHVGVVEILLDK 1110
Query: 549 GADVHAK-DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEI 607
G D+ A+ ++ PL ACS G EV +LL+ GA ++ +TPL AA+ G I
Sbjct: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI 1170
Query: 608 CKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSP 667
K+LL GA+ +R G+ G + L+ AA G + VK L
Sbjct: 1171 IKILLNAGAEIN--SRTGSK----------------LGISPLMLAAMNGHVPAVKLLLDM 1212
Query: 668 DNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDV 727
+ + +T L LA EV LL A+V + K GL PL AAS G+ +V
Sbjct: 1213 GSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1272
Query: 728 AALLIKYNACVNA--TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLV 785
+L+ A VNA T L AA KG + C LL+ GA ++N++G TPL L
Sbjct: 1273 GRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLA 1332
Query: 786 SAD---DVSALLTAA 797
S DV LL A
Sbjct: 1333 SNGGHFDVVQLLVQA 1347
Score = 108 bits (270), Expect = 3e-23
Identities = 111/410 (27%), Positives = 176/410 (42%), Gaps = 62/410 (15%)
Query: 431 NLGQT---SLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQM----GNENVQQLL-- 481
N GQ SL A G + R LL G N + +G + L + G + Q+L
Sbjct: 200 NAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLA 259
Query: 482 -QEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVS 540
+ ++ D L AA +G + KL + + +T L +A V
Sbjct: 260 MHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVD 319
Query: 541 VVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV-ADLWKFTPLHEA 599
+V+ LL GA++ ++ G PL A S GH EVA +L+ HGA +N ++ +K + L A
Sbjct: 320 IVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLA 379
Query: 600 AAKGKYEICKLLLQHGADPTKKNRDGNTPL-DLVKDGDTDIQDLL--------------- 643
KG ++ + LL+ GAD K + +T L + DG ++ LL
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
Query: 644 ------------------------------RGDAALLDAAKKGCLARVK-KLSSPDNVNC 672
G L++AA++G V L+ N+N
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
Query: 673 RDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLI 732
+ T+ T L LA EVA++L++ GAD+ + G PL A+ GH+++ L+
Sbjct: 500 Q-TEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLL 555
Query: 733 KYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPL 782
A V+AT T L A + G T + +LL GAD +++ G+TPL
Sbjct: 556 ASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL 605
Score = 108 bits (269), Expect = 4e-23
Identities = 104/389 (26%), Positives = 162/389 (41%), Gaps = 68/389 (17%)
Query: 236 DVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSL 295
D H + D L AC+ GH E+ +L+ A + D FTPL AA+ V V +
Sbjct: 1048 DAHTESNHDTA-LTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
Query: 296 LLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEM 355
LL G D
Sbjct: 1107 LLDKGGD----------------------------------------------------- 1113
Query: 356 VNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDV 415
+ + +T +T L A + R+++ +LLL +GAN + TPL +A+ + ++
Sbjct: 1114 IEAQSERTKDTPLSLACSGG---RQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI 1170
Query: 416 VEVVVKHEAKVNAL--DNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI-ISLQGFTALQM 472
+++++ A++N+ LG + L AA GH+ +LLL G D N I TAL +
Sbjct: 1171 IKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTL 1230
Query: 473 ----GNENVQQLLQEGISLGNSEADR---QLLEAAKAGDVETVKKLCTVQS-VNCRDIEG 524
G V LL + + A L+EAA G E + L + VN +
Sbjct: 1231 ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPS 1290
Query: 525 RQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAV 584
+ T L AA E L+ GA + ++K G PL A + GH++V +LLV+ GA
Sbjct: 1291 SRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGAD 1350
Query: 585 VNVADLWKFTPLHEAAAKGKYEICKLLLQ 613
V+ AD K TPL A KG ++ + L++
Sbjct: 1351 VDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 107 bits (268), Expect = 5e-23
Identities = 99/369 (26%), Positives = 155/369 (42%), Gaps = 52/369 (14%)
Query: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
T L +A H ++V V++ +AK+ D G T L AA GH+ +LL G D
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD--- 1113
Query: 462 ISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRD 521
I + L A +G + V L + N
Sbjct: 1114 -----------------------IEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEH 1150
Query: 522 IEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAK--DKGGLVPLHNACSYGHYEVAELLV 579
TPL AA V++++ LL GA+++++ K G+ PL A GH +LL+
Sbjct: 1151 RNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL 1210
Query: 580 KHGAVVNVA-DLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTD 638
G+ +N + + T L A +G+ E+ LLL A+ + + G TPL
Sbjct: 1211 DMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPL--------- 1261
Query: 639 IQDLLRGDAALLDAAKKGCLARVKK--LSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAE 696
++AA G A V + L +VN T L +AA + + E
Sbjct: 1262 -----------MEAASGG-YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCE 1309
Query: 697 YLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKG 756
L+ GA ++ ++K G PL A++ GH DV LL++ A V+A D TPL A +KG
Sbjct: 1310 LLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369
Query: 757 RTQLCALLL 765
++ L+
Sbjct: 1370 HVKVVQYLV 1378
Score = 103 bits (256), Expect = 1e-21
Identities = 106/378 (28%), Positives = 160/378 (42%), Gaps = 61/378 (16%)
Query: 364 HETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHE 423
H+TAL A A + +++ +L+ + A I + K+ TPL +A+ H VVE+++
Sbjct: 1055 HDTALTLACAGGH---EELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
Query: 424 AKVNAL-DNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQ 482
+ A + T L A G + LLL+ G + ++ +T L +
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSL---------- 1161
Query: 483 EGISLGNSEADRQLLEAAKAGDVETVKKLCTVQS-VNCRDIEGRQSTPLHFAAGYNRVSV 541
AA G V +K L + +N R +PL AA V
Sbjct: 1162 ----------------AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPA 1205
Query: 542 VEYLLQHGADVHAK-DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAA 600
V+ LL G+D++A+ + L AC G EV LL+ A V TPL EAA
Sbjct: 1206 VKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAA 1265
Query: 601 AKGKYEICKLLLQHGAD----PTKKNRDGNTPLDLVKD-GDTDIQDLLRGDAALLDAAKK 655
+ G E+ ++LL GAD P +RD T L + D G +LL A +D K
Sbjct: 1266 SGGYAEVGRVLLDKGADVNAPPVPSSRD--TALTIAADKGHYKFCELLIHRGAHIDVRNK 1323
Query: 656 GCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIP 715
+ +TPL LA+ + +V + L+Q GADV+A D + P
Sbjct: 1324 ----------------------KGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITP 1361
Query: 716 LHNAASYGHVDVAALLIK 733
L +A GHV V L+K
Sbjct: 1362 LMSAFRKGHVKVVQYLVK 1379
Score = 84.3 bits (207), Expect = 6e-16
Identities = 72/211 (34%), Positives = 93/211 (44%), Gaps = 31/211 (14%)
Query: 28 LFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQAR 87
L A NG V VK L+ + ++T L A GR +VV LL ANV+ R
Sbjct: 1194 LMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHR 1253
Query: 88 DDGGLIPLHNACSFGHAEVVNLLLRHGAD------PNARDNWNYTPLHEAAIKGKIDVCI 141
GL PL A S G+AEV +LL GAD P++RD T L AA KG C
Sbjct: 1254 AKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD----TALTIAADKGHYKFCE 1309
Query: 142 VLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLN 201
+L+ GA +RN G T L LA +G ++ LL
Sbjct: 1310 LLIHRGAHIDVRNKKGNTPLWLAS---------------------NGGHFDVVQLLVQAG 1348
Query: 202 VNCHASDGRKSTPLHLAAGYNRVKIVQLLLQ 232
+ A+D RK TPL A VK+VQ L++
Sbjct: 1349 ADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 159 bits (403), Expect = 1e-38
Identities = 164/560 (29%), Positives = 242/560 (43%), Gaps = 80/560 (14%)
Query: 26 RELFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANV 84
R L EAC +GDV V++L+ VN G L +AG+ ++ + LL ANV
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGY--YELAQVLLAMHANV 264
Query: 85 QAR-DDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVL 143
+ R + G + PL A S G+ ++V LLL H AD N++ T L A G +D+ VL
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 144 LQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLT-PLNV 202
L GA N +G T L+E+A +G+ E LL +
Sbjct: 325 LNEGANIEDHNENGHT--------------------PLMEAASAGHVEVARVLLDHGAGI 364
Query: 203 NCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTEL 262
N H+++ ++S L LA + +V+ LL+ GAD K L AC GH EV L
Sbjct: 365 NTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 423
Query: 263 LVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQL 322
L+ GA VN +PL AA VE+ +LL+ GA+ +N D TP
Sbjct: 424 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN-------DEGYTP-- 474
Query: 323 KERLAYEFKGHSLLQAAREADVTRIKKHLSL-EMVNFKHPQTHETALHCAAASPYPKRKQ 381
L++AARE + L+ +N + +T ETAL A + +
Sbjct: 475 ------------LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGF---SE 519
Query: 382 ICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAA 441
+ + L++ GA+I TPL AS++ H ++V+ ++ A V+A G T+L A
Sbjct: 520 VADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 576
Query: 442 YCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAK 501
GH +LL G D S G T L++AA+
Sbjct: 577 ENGHTDVADVLLQAGADLEHESEGGRT--------------------------PLMKAAR 610
Query: 502 AGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLV 561
AG + TV+ L + + R T + A ++VVE LL HGAD + K G
Sbjct: 611 AGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGST 670
Query: 562 PLHNACSYGHYEVAELLVKH 581
L A GH V L+ +
Sbjct: 671 MLIEAAKGGHTNVVSYLLDY 690
Score = 154 bits (389), Expect = 5e-37
Identities = 145/496 (29%), Positives = 221/496 (44%), Gaps = 78/496 (15%)
Query: 334 SLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANI 393
SL +A + DV ++K L +H + E+ L A ++ Y ++ ++LL AN+
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGY---YELAQVLLAMHANV 264
Query: 394 NEK-TKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLL 452
++ K +TPL AS + D+V++++ H+A VN+ G T+L A G + ++L
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 453 LSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLC 512
L+ G + ++ NEN L E S G+ E R LL+
Sbjct: 325 LNEGAN-----------IEDHNENGHTPLMEAASAGHVEVARVLLDHGAG---------- 363
Query: 513 TVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHY 572
+N E ++S L A + +V +LL+ GAD K L AC GH
Sbjct: 364 ----INTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 418
Query: 573 EVAELLVKHGAVVNV-ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPL-D 630
EVA LL+ GA VN+ AD ++ +PL AA G E+ LL++ GA+ + N +G TPL +
Sbjct: 419 EVARLLLDSGAQVNMPADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLME 477
Query: 631 LVKDGDTDIQDLLRGDAA------------------------------------------ 648
++G ++ LL A
Sbjct: 478 AAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCST 537
Query: 649 -LLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNA 707
L++A+++G L VK L + N T T L A + +VA+ LLQ GAD+
Sbjct: 538 PLMEASQEGHLELVKYLLA-SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
Query: 708 QDKGGLIPLHNAASYGHVDVAALLIKYNACVN-ATDKWAFTPLHEAAQKGRTQLCALLLA 766
+ +GG PL AA GH+ LI A VN AT T + A G + LLLA
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656
Query: 767 HGADPTLKNQEGQTPL 782
HGADPT + ++G T L
Sbjct: 657 HGADPTHRLKDGSTML 672
Score = 146 bits (369), Expect = 1e-34
Identities = 170/580 (29%), Positives = 241/580 (41%), Gaps = 90/580 (15%)
Query: 181 LLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADV--H 238
L S +E AL N H + + L A V V+ LL G V H
Sbjct: 175 LTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEH 234
Query: 239 AKDKGDLVPLHNACSYGHYEVTE-LLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLL 297
++ L+ L ACS G+YE+ + LL H + + TPL A+S +++ LLL
Sbjct: 235 TEEGESLLCL--ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL 292
Query: 298 SYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVN 357
+ +ADV
Sbjct: 293 LH-----------------------------------------DADVN------------ 299
Query: 358 FKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVE 417
T TAL A A + I ++LL +GANI + + TPL A+ H +V
Sbjct: 300 -SQSATGNTALTYACAGGFV---DIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 355
Query: 418 VVVKHEAKVNALDN-LGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQM---- 472
V++ H A +N N +++L A Y GHL R LL G D + + TAL
Sbjct: 356 VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 415
Query: 473 GNENVQQLLQEGISLGNSEADR---QLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTP 529
G+ V +LL + + N AD L AA G VE + L + N ++ TP
Sbjct: 416 GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE-LAALLIERGANLEEVNDEGYTP 474
Query: 530 LHFAAGYNRVSVVEYLLQHGADVHAK-DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVA 588
L AA +V LL GA+++A+ ++ L AC G EVA+ L+K GA +
Sbjct: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI--- 531
Query: 589 DLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV-KDGDTDIQDLLR--- 644
+L TPL EA+ +G E+ K LL GA+ G+T L ++G TD+ D+L
Sbjct: 532 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
Query: 645 ---------GDAALLDAAKKGCLARVKKLSSPD-NVNCRDTQGRHSTPLHLAAGYNNLEV 694
G L+ AA+ G L V+ L S NVN R T T + LA +L V
Sbjct: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVN-RATANNDHTVVSLACAGGHLAV 650
Query: 695 AEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKY 734
E LL HGAD + K G L AA GH +V + L+ Y
Sbjct: 651 VELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 120 bits (301), Expect = 8e-27
Identities = 106/302 (35%), Positives = 147/302 (48%), Gaps = 19/302 (6%)
Query: 494 RQLLEAAKAGDVETVKKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADV 552
R L EA GDV V+KL +SVN EG L +AGY ++ V LL A+V
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV--LLAMHANV 264
Query: 553 HAK-DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLL 611
+ +KG + PL A S G+ ++ +LL+ H A VN T L A A G +I K+L
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 612 LQHGADPTKKNRDGNTPL-DLVKDGDTDIQDLLRG-------------DAALLDAAKKGC 657
L GA+ N +G+TPL + G ++ +L ++AL A KG
Sbjct: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 384
Query: 658 LARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLH 717
L V+ L T H T L A ++EVA LL GA VN PL
Sbjct: 385 LDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443
Query: 718 NAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQE 777
AA GHV++AALLI+ A + + +TPL EAA++G ++ ALLLA GA+ + +E
Sbjct: 444 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503
Query: 778 GQ 779
Q
Sbjct: 504 TQ 505
Score = 119 bits (297), Expect = 2e-26
Identities = 118/404 (29%), Positives = 166/404 (41%), Gaps = 80/404 (19%)
Query: 54 TAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRH 113
T T L A G +++V L+ A ++ RD G PL A + GH VV +LL
Sbjct: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110
Query: 114 GADPNAR-DNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVL 172
G D A+ + TPL A G+ +V +LL GA RN T L L
Sbjct: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSL--------- 1161
Query: 173 TGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRK--STPLHLAAGYNRVKIVQLL 230
A SG ++ +L ++ G K +PL LAA V V+LL
Sbjct: 1162 ------------AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLL 1209
Query: 231 LQHGADVHAK-DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNR 289
L G+D++A+ + L AC G EV LL+ A V TPL EAAS
Sbjct: 1210 LDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGY 1269
Query: 290 VEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKK 349
EV +LL GAD ++ P P
Sbjct: 1270 AEVGRVLLDKGAD-----------VNAPPVP----------------------------- 1289
Query: 350 HLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASE 409
+ +TAL AA + K CELL+ +GA+I+ + K+ TPL +AS
Sbjct: 1290 ------------SSRDTALTIAADKGHYK---FCELLIHRGAHIDVRNKKGNTPLWLASN 1334
Query: 410 KAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLL 453
H DVV+++V+ A V+A DN T L A GH++ + L+
Sbjct: 1335 GGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
Score = 113 bits (283), Expect = 9e-25
Identities = 105/364 (28%), Positives = 169/364 (46%), Gaps = 35/364 (9%)
Query: 166 PSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVK 225
PS E D L A +G E+++++L + D + TPL LAA V
Sbjct: 1043 PSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVG 1102
Query: 226 IVQLLLQHGADVHAK-DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEA 284
+V++LL G D+ A+ ++ PL ACS G EV +LL+ GA ++ +TPL A
Sbjct: 1103 VVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162
Query: 285 ASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADV 344
AS V + +LL+ GA+ +N S + ++P L+ AA V
Sbjct: 1163 ASGGYVNIIKILLNAGAE---INSRTGSKLGISP----------------LMLAAMNGHV 1203
Query: 345 TRIKKHLSL-EMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTP 403
+K L + +N + TAL A + R ++ LLL + AN+ + K LTP
Sbjct: 1204 PAVKLLLDMGSDINAQIETNRNTALTLAC---FQGRAEVVSLLLDRKANVEHRAKTGLTP 1260
Query: 404 LHVASEKAHNDVVEVVVKHEAKVNA--LDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
L A+ + +V V++ A VNA + + T+L AA GH + C LL+ G ++
Sbjct: 1261 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV 1320
Query: 462 ISLQGFTALQMGNEN-----VQQLLQEG--ISLGNSEADRQLLEAAKAGDVETVKKLCTV 514
+ +G T L + + VQ L+Q G + ++ L+ A + G V+ V+ L V
Sbjct: 1321 RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYL--V 1378
Query: 515 QSVN 518
+ VN
Sbjct: 1379 KEVN 1382
Score = 111 bits (277), Expect = 5e-24
Identities = 116/404 (28%), Positives = 169/404 (41%), Gaps = 60/404 (14%)
Query: 31 ACRNGDVERVKRLVTPE-KVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDD 89
AC G E V L+ + K+ RD G TPL AA G VVE LL G +++A+ +
Sbjct: 1062 ACAGGHEELVSVLIARDAKIEHRDKKG--FTPLILAATAGHVGVVEILLDKGGDIEAQSE 1119
Query: 90 GGL-IPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGA 148
PL ACS G EVV+LLL GA+ R+ +YTPL AA G +++ +LL GA
Sbjct: 1120 RTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGA 1179
Query: 149 E-----------------------PTIR-------------NTDGRTALDLA-------- 164
E P ++ T+ TAL LA
Sbjct: 1180 EINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEV 1239
Query: 165 -----DPSAKAVLTGEYKKDELLESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLHLA 218
D A + L+E+A G E LL +VN + T L +A
Sbjct: 1240 VSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIA 1299
Query: 219 AGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQF 278
A K +LL+ GA + ++K PL A + GH++V +LLV+ GA V+A D +
Sbjct: 1300 ADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKI 1359
Query: 279 TPLHEAASKNRVEVCSLLL-SYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQ 337
TPL A K V+V L+ P+ + C A T KE L + +
Sbjct: 1360 TPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIA-----TITDKELLKKCHQCVETIV 1414
Query: 338 AAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQ 381
A++ K+ S+ + ++ E + A A+ KRK+
Sbjct: 1415 KAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKE 1458
Score = 110 bits (275), Expect = 8e-24
Identities = 107/315 (33%), Positives = 142/315 (45%), Gaps = 27/315 (8%)
Query: 490 SEADRQLLEAAKAGDVETVKKLCTVQS-VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQH 548
S D L A G E V L + + RD +G TPL AA V VVE LL
Sbjct: 1053 SNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKG--FTPLILAATAGHVGVVEILLDK 1110
Query: 549 GADVHAK-DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEI 607
G D+ A+ ++ PL ACS G EV +LL+ GA ++ +TPL AA+ G I
Sbjct: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI 1170
Query: 608 CKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSP 667
K+LL GA+ +R G+ G + L+ AA G + VK L
Sbjct: 1171 IKILLNAGAEIN--SRTGSK----------------LGISPLMLAAMNGHVPAVKLLLDM 1212
Query: 668 DNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDV 727
+ + +T L LA EV LL A+V + K GL PL AAS G+ +V
Sbjct: 1213 GSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1272
Query: 728 AALLIKYNACVNA--TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLV 785
+L+ A VNA T L AA KG + C LL+ GA ++N++G TPL L
Sbjct: 1273 GRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLA 1332
Query: 786 SAD---DVSALLTAA 797
S DV LL A
Sbjct: 1333 SNGGHFDVVQLLVQA 1347
Score = 108 bits (270), Expect = 3e-23
Identities = 111/410 (27%), Positives = 176/410 (42%), Gaps = 62/410 (15%)
Query: 431 NLGQT---SLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQM----GNENVQQLL-- 481
N GQ SL A G + R LL G N + +G + L + G + Q+L
Sbjct: 200 NAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLA 259
Query: 482 -QEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVS 540
+ ++ D L AA +G + KL + + +T L +A V
Sbjct: 260 MHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVD 319
Query: 541 VVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV-ADLWKFTPLHEA 599
+V+ LL GA++ ++ G PL A S GH EVA +L+ HGA +N ++ +K + L A
Sbjct: 320 IVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLA 379
Query: 600 AAKGKYEICKLLLQHGADPTKKNRDGNTPL-DLVKDGDTDIQDLL--------------- 643
KG ++ + LL+ GAD K + +T L + DG ++ LL
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
Query: 644 ------------------------------RGDAALLDAAKKGCLARVK-KLSSPDNVNC 672
G L++AA++G V L+ N+N
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
Query: 673 RDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLI 732
+ T+ T L LA EVA++L++ GAD+ + G PL A+ GH+++ L+
Sbjct: 500 Q-TEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLL 555
Query: 733 KYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPL 782
A V+AT T L A + G T + +LL GAD +++ G+TPL
Sbjct: 556 ASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL 605
Score = 108 bits (269), Expect = 4e-23
Identities = 104/389 (26%), Positives = 162/389 (41%), Gaps = 68/389 (17%)
Query: 236 DVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSL 295
D H + D L AC+ GH E+ +L+ A + D FTPL AA+ V V +
Sbjct: 1048 DAHTESNHDTA-LTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
Query: 296 LLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEM 355
LL G D
Sbjct: 1107 LLDKGGD----------------------------------------------------- 1113
Query: 356 VNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDV 415
+ + +T +T L A + R+++ +LLL +GAN + TPL +A+ + ++
Sbjct: 1114 IEAQSERTKDTPLSLACSGG---RQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI 1170
Query: 416 VEVVVKHEAKVNAL--DNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI-ISLQGFTALQM 472
+++++ A++N+ LG + L AA GH+ +LLL G D N I TAL +
Sbjct: 1171 IKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTL 1230
Query: 473 ----GNENVQQLLQEGISLGNSEADR---QLLEAAKAGDVETVKKLCTVQS-VNCRDIEG 524
G V LL + + A L+EAA G E + L + VN +
Sbjct: 1231 ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPS 1290
Query: 525 RQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAV 584
+ T L AA E L+ GA + ++K G PL A + GH++V +LLV+ GA
Sbjct: 1291 SRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGAD 1350
Query: 585 VNVADLWKFTPLHEAAAKGKYEICKLLLQ 613
V+ AD K TPL A KG ++ + L++
Sbjct: 1351 VDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 107 bits (268), Expect = 5e-23
Identities = 99/369 (26%), Positives = 155/369 (42%), Gaps = 52/369 (14%)
Query: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
T L +A H ++V V++ +AK+ D G T L AA GH+ +LL G D
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD--- 1113
Query: 462 ISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRD 521
I + L A +G + V L + N
Sbjct: 1114 -----------------------IEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEH 1150
Query: 522 IEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAK--DKGGLVPLHNACSYGHYEVAELLV 579
TPL AA V++++ LL GA+++++ K G+ PL A GH +LL+
Sbjct: 1151 RNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL 1210
Query: 580 KHGAVVNVA-DLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTD 638
G+ +N + + T L A +G+ E+ LLL A+ + + G TPL
Sbjct: 1211 DMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPL--------- 1261
Query: 639 IQDLLRGDAALLDAAKKGCLARVKK--LSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAE 696
++AA G A V + L +VN T L +AA + + E
Sbjct: 1262 -----------MEAASGG-YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCE 1309
Query: 697 YLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKG 756
L+ GA ++ ++K G PL A++ GH DV LL++ A V+A D TPL A +KG
Sbjct: 1310 LLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369
Query: 757 RTQLCALLL 765
++ L+
Sbjct: 1370 HVKVVQYLV 1378
Score = 103 bits (256), Expect = 1e-21
Identities = 106/378 (28%), Positives = 160/378 (42%), Gaps = 61/378 (16%)
Query: 364 HETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHE 423
H+TAL A A + +++ +L+ + A I + K+ TPL +A+ H VVE+++
Sbjct: 1055 HDTALTLACAGGH---EELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
Query: 424 AKVNAL-DNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQ 482
+ A + T L A G + LLL+ G + ++ +T L +
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSL---------- 1161
Query: 483 EGISLGNSEADRQLLEAAKAGDVETVKKLCTVQS-VNCRDIEGRQSTPLHFAAGYNRVSV 541
AA G V +K L + +N R +PL AA V
Sbjct: 1162 ----------------AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPA 1205
Query: 542 VEYLLQHGADVHAK-DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAA 600
V+ LL G+D++A+ + L AC G EV LL+ A V TPL EAA
Sbjct: 1206 VKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAA 1265
Query: 601 AKGKYEICKLLLQHGAD----PTKKNRDGNTPLDLVKD-GDTDIQDLLRGDAALLDAAKK 655
+ G E+ ++LL GAD P +RD T L + D G +LL A +D K
Sbjct: 1266 SGGYAEVGRVLLDKGADVNAPPVPSSRD--TALTIAADKGHYKFCELLIHRGAHIDVRNK 1323
Query: 656 GCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIP 715
+ +TPL LA+ + +V + L+Q GADV+A D + P
Sbjct: 1324 ----------------------KGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITP 1361
Query: 716 LHNAASYGHVDVAALLIK 733
L +A GHV V L+K
Sbjct: 1362 LMSAFRKGHVKVVQYLVK 1379
Score = 84.3 bits (207), Expect = 6e-16
Identities = 72/211 (34%), Positives = 93/211 (44%), Gaps = 31/211 (14%)
Query: 28 LFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQAR 87
L A NG V VK L+ + ++T L A GR +VV LL ANV+ R
Sbjct: 1194 LMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHR 1253
Query: 88 DDGGLIPLHNACSFGHAEVVNLLLRHGAD------PNARDNWNYTPLHEAAIKGKIDVCI 141
GL PL A S G+AEV +LL GAD P++RD T L AA KG C
Sbjct: 1254 AKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD----TALTIAADKGHYKFCE 1309
Query: 142 VLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLN 201
+L+ GA +RN G T L LA +G ++ LL
Sbjct: 1310 LLIHRGAHIDVRNKKGNTPLWLAS---------------------NGGHFDVVQLLVQAG 1348
Query: 202 VNCHASDGRKSTPLHLAAGYNRVKIVQLLLQ 232
+ A+D RK TPL A VK+VQ L++
Sbjct: 1349 ADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 142 bits (359), Expect = 1e-33
Identities = 129/440 (29%), Positives = 205/440 (46%), Gaps = 57/440 (12%)
Query: 334 SLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANI 393
SL +A + DV ++K L +H + E+ L A ++ Y ++ ++LL AN+
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGY---YELAQVLLAMHANV 264
Query: 394 NEK-TKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLL 452
++ K +TPL AS + D+V++++ H+A VN+ G T+L A G + ++L
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 453 LSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLC 512
L+ G + ++ NEN L E S G+ E R LL+
Sbjct: 325 LNEGAN-----------IEDHNENGHTPLMEAASAGHVEVARVLLDHGAG---------- 363
Query: 513 TVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHY 572
+N E ++S L A + +V +LL+ GAD K L AC GH
Sbjct: 364 ----INTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 418
Query: 573 EVAELLVKHGAVVNV-ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPL-D 630
EVA LL+ GA VN+ AD ++ +PL AA G E+ LL++ GA+ + N +G TPL +
Sbjct: 419 EVARLLLDSGAQVNMPADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLME 477
Query: 631 LVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYN 690
++G ++ LL A N+N + T+ T L LA
Sbjct: 478 AAREGHEEMVALLLAQGA--------------------NINAQ-TEETQETALTLACCGG 516
Query: 691 NLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLH 750
EVA++L++ GAD+ + G PL A+ GH+++ L+ A V+AT T L
Sbjct: 517 FSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 573
Query: 751 EAAQKGRTQLCALLLAHGAD 770
A + G T + +LL GAD
Sbjct: 574 YACENGHTDVADVLLQAGAD 593
Score = 139 bits (351), Expect = 1e-32
Identities = 133/437 (30%), Positives = 198/437 (45%), Gaps = 54/437 (12%)
Query: 26 RELFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANV 84
R L EAC +GDV V++L+ VN G L +AG+ ++ + LL ANV
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGY--YELAQVLLAMHANV 264
Query: 85 QAR-DDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVL 143
+ R + G + PL A S G+ ++V LLL H AD N++ T L A G +D+ VL
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 144 LQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLT-PLNV 202
L GA N +G T L+E+A +G+ E LL +
Sbjct: 325 LNEGANIEDHNENGHT--------------------PLMEAASAGHVEVARVLLDHGAGI 364
Query: 203 NCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTEL 262
N H+++ ++S L LA + +V+ LL+ GAD K L AC GH EV L
Sbjct: 365 NTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 423
Query: 263 LVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQL 322
L+ GA VN +PL AA VE+ +LL+ GA+ +N D TP
Sbjct: 424 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN-------DEGYTP-- 474
Query: 323 KERLAYEFKGHSLLQAAREADVTRIKKHLSL-EMVNFKHPQTHETALHCAAASPYPKRKQ 381
L++AARE + L+ +N + +T ETAL A + +
Sbjct: 475 ------------LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGF---SE 519
Query: 382 ICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAA 441
+ + L++ GA+I TPL AS++ H ++V+ ++ A V+A G T+L A
Sbjct: 520 VADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 576
Query: 442 YCGHLQTCRLLLSYGCD 458
GH +LL G D
Sbjct: 577 ENGHTDVADVLLQAGAD 593
Score = 120 bits (301), Expect = 8e-27
Identities = 106/302 (35%), Positives = 147/302 (48%), Gaps = 19/302 (6%)
Query: 494 RQLLEAAKAGDVETVKKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADV 552
R L EA GDV V+KL +SVN EG L +AGY ++ V LL A+V
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV--LLAMHANV 264
Query: 553 HAK-DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLL 611
+ +KG + PL A S G+ ++ +LL+ H A VN T L A A G +I K+L
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 612 LQHGADPTKKNRDGNTPL-DLVKDGDTDIQDLLRG-------------DAALLDAAKKGC 657
L GA+ N +G+TPL + G ++ +L ++AL A KG
Sbjct: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 384
Query: 658 LARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLH 717
L V+ L T H T L A ++EVA LL GA VN PL
Sbjct: 385 LDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443
Query: 718 NAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQE 777
AA GHV++AALLI+ A + + +TPL EAA++G ++ ALLLA GA+ + +E
Sbjct: 444 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503
Query: 778 GQ 779
Q
Sbjct: 504 TQ 505
Score = 119 bits (298), Expect = 2e-26
Identities = 126/455 (27%), Positives = 199/455 (43%), Gaps = 49/455 (10%)
Query: 174 GEYKKDELLESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQ 232
G+ L E+ G+ + LL +VN H +G L +AGY ++ Q+LL
Sbjct: 202 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGY--YELAQVLLA 259
Query: 233 HGADVHAK-DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVE 291
A+V + +KGD+ PL A S G+ ++ +LL+ H A VN+ T L A + V+
Sbjct: 260 MHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVD 319
Query: 292 VCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHL 351
+ +LL+ GA+ + HN++ GH+ L A A + + L
Sbjct: 320 IVKVLLNEGAN---IEDHNEN-------------------GHTPLMEAASAGHVEVARVL 357
Query: 352 SLEM--VNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASE 409
+N + E+AL A Y + LL GA+ KT E T L A
Sbjct: 358 LDHGAGINTHSNEFKESALTLAC---YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 414
Query: 410 KAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTA 469
H +V +++ A+VN + ++ L AA GH++ LL+ G + ++ +G+T
Sbjct: 415 DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 474
Query: 470 LQMG-----NENVQQLLQEGISLG--NSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDI 522
L E V LL +G ++ E L A G V DI
Sbjct: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DI 531
Query: 523 EGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHG 582
E STPL A+ + +V+YLL GA+VHA G L AC GH +VA++L++ G
Sbjct: 532 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
Query: 583 AVVNVADLWKFTPLHEAAAKGKYEI------CKLL 611
A ++ + K + E K+++ CKLL
Sbjct: 592 ADLDKQEDMK--TILEGIDPAKHQVRVAFDACKLL 624
Score = 106 bits (264), Expect = 1e-22
Identities = 109/376 (28%), Positives = 162/376 (43%), Gaps = 27/376 (7%)
Query: 431 NLGQT---SLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQM----GNENVQQLL-- 481
N GQ SL A G + R LL G N + +G + L + G + Q+L
Sbjct: 200 NAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLA 259
Query: 482 -QEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVS 540
+ ++ D L AA +G + KL + + +T L +A V
Sbjct: 260 MHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVD 319
Query: 541 VVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV-ADLWKFTPLHEA 599
+V+ LL GA++ ++ G PL A S GH EVA +L+ HGA +N ++ +K + L A
Sbjct: 320 IVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLA 379
Query: 600 AAKGKYEICKLLLQHGADPTKKNRDGNTPL-DLVKDGDTDIQDLLRGDAAL--------- 649
KG ++ + LL+ GAD K + +T L + DG ++ LL A
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
Query: 650 --LDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNA 707
L A G + L N + TPL AA + E+ LL GA++NA
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
Query: 708 Q-DKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLA 766
Q ++ L A G +VA LIK A + + TPL EA+Q+G +L LLA
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLA 556
Query: 767 HGADPTLKNQEGQTPL 782
GA+ G T L
Sbjct: 557 SGANVHATTATGDTAL 572
Score = 70.9 bits (172), Expect = 7e-12
Identities = 64/215 (29%), Positives = 95/215 (44%), Gaps = 26/215 (12%)
Query: 28 LFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQAR 87
L EAC +G VE V RL+ A +PL AA G ++ L++ GAN++
Sbjct: 409 LMEACMDGHVE-VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEV 467
Query: 88 DDGGLIPLHNACSFGHAEVVNLLLRHGADPNAR-DNWNYTPLHEAAIKGKIDVCIVLLQH 146
+D G PL A GH E+V LLL GA+ NA+ + T L A G +V L++
Sbjct: 468 NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA 527
Query: 147 GAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHA 206
GA+ L + P L+E+++ G+ E + LL N HA
Sbjct: 528 GAD---------IELGCSTP--------------LMEASQEGHLELVKYLLAS-GANVHA 563
Query: 207 SDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKD 241
+ T L A + +LLQ GAD+ ++
Sbjct: 564 TTATGDTALTYACENGHTDVADVLLQAGADLDKQE 598
Score = 49.3 bits (116), Expect = 2e-05
Identities = 27/64 (42%), Positives = 40/64 (62%)
Query: 59 STPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPN 118
STPL A+ G ++V+YLL +GANV A G L AC GH +V ++LL+ GAD +
Sbjct: 536 STPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
Query: 119 ARDN 122
+++
Sbjct: 596 KQED 599
Score = 37.7 bits (86), Expect = 0.064
Identities = 28/88 (31%), Positives = 40/88 (45%), Gaps = 5/88 (5%)
Query: 6 CAGGGAACAS----AAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTP 61
C GG + A A A+ + L EA + G +E VK L+ N T T
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLA-SGANVHATTATGDTA 571
Query: 62 LHFAAGFGRKDVVEYLLQNGANVQARDD 89
L +A G DV + LLQ GA++ ++D
Sbjct: 572 LTYACENGHTDVADVLLQAGADLDKQED 599
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 142 bits (359), Expect = 1e-33
Identities = 129/440 (29%), Positives = 205/440 (46%), Gaps = 57/440 (12%)
Query: 334 SLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANI 393
SL +A + DV ++K L +H + E+ L A ++ Y ++ ++LL AN+
Sbjct: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGY---YELAQVLLAMHANV 253
Query: 394 NEK-TKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLL 452
++ K +TPL AS + D+V++++ H+A VN+ G T+L A G + ++L
Sbjct: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
Query: 453 LSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLC 512
L+ G + ++ NEN L E S G+ E R LL+
Sbjct: 314 LNEGAN-----------IEDHNENGHTPLMEAASAGHVEVARVLLDHGAG---------- 352
Query: 513 TVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHY 572
+N E ++S L A + +V +LL+ GAD K L AC GH
Sbjct: 353 ----INTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 407
Query: 573 EVAELLVKHGAVVNV-ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPL-D 630
EVA LL+ GA VN+ AD ++ +PL AA G E+ LL++ GA+ + N +G TPL +
Sbjct: 408 EVARLLLDSGAQVNMPADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLME 466
Query: 631 LVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYN 690
++G ++ LL A N+N + T+ T L LA
Sbjct: 467 AAREGHEEMVALLLAQGA--------------------NINAQ-TEETQETALTLACCGG 505
Query: 691 NLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLH 750
EVA++L++ GAD+ + G PL A+ GH+++ L+ A V+AT T L
Sbjct: 506 FSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 562
Query: 751 EAAQKGRTQLCALLLAHGAD 770
A + G T + +LL GAD
Sbjct: 563 YACENGHTDVADVLLQAGAD 582
Score = 139 bits (351), Expect = 1e-32
Identities = 133/437 (30%), Positives = 198/437 (45%), Gaps = 54/437 (12%)
Query: 26 RELFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANV 84
R L EAC +GDV V++L+ VN G L +AG+ ++ + LL ANV
Sbjct: 196 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGY--YELAQVLLAMHANV 253
Query: 85 QAR-DDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVL 143
+ R + G + PL A S G+ ++V LLL H AD N++ T L A G +D+ VL
Sbjct: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
Query: 144 LQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLT-PLNV 202
L GA N +G T L+E+A +G+ E LL +
Sbjct: 314 LNEGANIEDHNENGHT--------------------PLMEAASAGHVEVARVLLDHGAGI 353
Query: 203 NCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTEL 262
N H+++ ++S L LA + +V+ LL+ GAD K L AC GH EV L
Sbjct: 354 NTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 412
Query: 263 LVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQL 322
L+ GA VN +PL AA VE+ +LL+ GA+ +N D TP
Sbjct: 413 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN-------DEGYTP-- 463
Query: 323 KERLAYEFKGHSLLQAAREADVTRIKKHLSL-EMVNFKHPQTHETALHCAAASPYPKRKQ 381
L++AARE + L+ +N + +T ETAL A + +
Sbjct: 464 ------------LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGF---SE 508
Query: 382 ICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAA 441
+ + L++ GA+I TPL AS++ H ++V+ ++ A V+A G T+L A
Sbjct: 509 VADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 565
Query: 442 YCGHLQTCRLLLSYGCD 458
GH +LL G D
Sbjct: 566 ENGHTDVADVLLQAGAD 582
Score = 120 bits (301), Expect = 8e-27
Identities = 106/302 (35%), Positives = 147/302 (48%), Gaps = 19/302 (6%)
Query: 494 RQLLEAAKAGDVETVKKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADV 552
R L EA GDV V+KL +SVN EG L +AGY ++ V LL A+V
Sbjct: 196 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV--LLAMHANV 253
Query: 553 HAK-DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLL 611
+ +KG + PL A S G+ ++ +LL+ H A VN T L A A G +I K+L
Sbjct: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
Query: 612 LQHGADPTKKNRDGNTPL-DLVKDGDTDIQDLLRG-------------DAALLDAAKKGC 657
L GA+ N +G+TPL + G ++ +L ++AL A KG
Sbjct: 314 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 373
Query: 658 LARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLH 717
L V+ L T H T L A ++EVA LL GA VN PL
Sbjct: 374 LDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 432
Query: 718 NAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQE 777
AA GHV++AALLI+ A + + +TPL EAA++G ++ ALLLA GA+ + +E
Sbjct: 433 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492
Query: 778 GQ 779
Q
Sbjct: 493 TQ 494
Score = 119 bits (298), Expect = 2e-26
Identities = 126/455 (27%), Positives = 199/455 (43%), Gaps = 49/455 (10%)
Query: 174 GEYKKDELLESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQ 232
G+ L E+ G+ + LL +VN H +G L +AGY ++ Q+LL
Sbjct: 191 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGY--YELAQVLLA 248
Query: 233 HGADVHAK-DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVE 291
A+V + +KGD+ PL A S G+ ++ +LL+ H A VN+ T L A + V+
Sbjct: 249 MHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVD 308
Query: 292 VCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHL 351
+ +LL+ GA+ + HN++ GH+ L A A + + L
Sbjct: 309 IVKVLLNEGAN---IEDHNEN-------------------GHTPLMEAASAGHVEVARVL 346
Query: 352 SLEM--VNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASE 409
+N + E+AL A Y + LL GA+ KT E T L A
Sbjct: 347 LDHGAGINTHSNEFKESALTLAC---YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 403
Query: 410 KAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTA 469
H +V +++ A+VN + ++ L AA GH++ LL+ G + ++ +G+T
Sbjct: 404 DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 463
Query: 470 LQMG-----NENVQQLLQEGISLG--NSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDI 522
L E V LL +G ++ E L A G V DI
Sbjct: 464 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DI 520
Query: 523 EGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHG 582
E STPL A+ + +V+YLL GA+VHA G L AC GH +VA++L++ G
Sbjct: 521 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 580
Query: 583 AVVNVADLWKFTPLHEAAAKGKYEI------CKLL 611
A ++ + K + E K+++ CKLL
Sbjct: 581 ADLDKQEDMK--TILEGIDPAKHQVRVAFDACKLL 613
Score = 106 bits (264), Expect = 1e-22
Identities = 109/376 (28%), Positives = 162/376 (43%), Gaps = 27/376 (7%)
Query: 431 NLGQT---SLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQM----GNENVQQLL-- 481
N GQ SL A G + R LL G N + +G + L + G + Q+L
Sbjct: 189 NAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLA 248
Query: 482 -QEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVS 540
+ ++ D L AA +G + KL + + +T L +A V
Sbjct: 249 MHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVD 308
Query: 541 VVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV-ADLWKFTPLHEA 599
+V+ LL GA++ ++ G PL A S GH EVA +L+ HGA +N ++ +K + L A
Sbjct: 309 IVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLA 368
Query: 600 AAKGKYEICKLLLQHGADPTKKNRDGNTPL-DLVKDGDTDIQDLLRGDAAL--------- 649
KG ++ + LL+ GAD K + +T L + DG ++ LL A
Sbjct: 369 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 428
Query: 650 --LDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNA 707
L A G + L N + TPL AA + E+ LL GA++NA
Sbjct: 429 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 488
Query: 708 Q-DKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLA 766
Q ++ L A G +VA LIK A + + TPL EA+Q+G +L LLA
Sbjct: 489 QTEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLA 545
Query: 767 HGADPTLKNQEGQTPL 782
GA+ G T L
Sbjct: 546 SGANVHATTATGDTAL 561
Score = 70.9 bits (172), Expect = 7e-12
Identities = 64/215 (29%), Positives = 95/215 (44%), Gaps = 26/215 (12%)
Query: 28 LFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQAR 87
L EAC +G VE V RL+ A +PL AA G ++ L++ GAN++
Sbjct: 398 LMEACMDGHVE-VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEV 456
Query: 88 DDGGLIPLHNACSFGHAEVVNLLLRHGADPNAR-DNWNYTPLHEAAIKGKIDVCIVLLQH 146
+D G PL A GH E+V LLL GA+ NA+ + T L A G +V L++
Sbjct: 457 NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA 516
Query: 147 GAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHA 206
GA+ L + P L+E+++ G+ E + LL N HA
Sbjct: 517 GAD---------IELGCSTP--------------LMEASQEGHLELVKYLLAS-GANVHA 552
Query: 207 SDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKD 241
+ T L A + +LLQ GAD+ ++
Sbjct: 553 TTATGDTALTYACENGHTDVADVLLQAGADLDKQE 587
Score = 49.3 bits (116), Expect = 2e-05
Identities = 27/64 (42%), Positives = 40/64 (62%)
Query: 59 STPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPN 118
STPL A+ G ++V+YLL +GANV A G L AC GH +V ++LL+ GAD +
Sbjct: 525 STPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
Query: 119 ARDN 122
+++
Sbjct: 585 KQED 588
Score = 37.7 bits (86), Expect = 0.064
Identities = 28/88 (31%), Positives = 40/88 (45%), Gaps = 5/88 (5%)
Query: 6 CAGGGAACAS----AAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTP 61
C GG + A A A+ + L EA + G +E VK L+ N T T
Sbjct: 502 CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLA-SGANVHATTATGDTA 560
Query: 62 LHFAAGFGRKDVVEYLLQNGANVQARDD 89
L +A G DV + LLQ GA++ ++D
Sbjct: 561 LTYACENGHTDVADVLLQAGADLDKQED 588
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 139 bits (349), Expect = 2e-32
Identities = 153/567 (26%), Positives = 238/567 (41%), Gaps = 52/567 (9%)
Query: 167 SAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKI 226
S + G ++ +A +G++ + L+ + D TPL +R+
Sbjct: 4 SENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDC 63
Query: 227 VQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAAS 286
LL+ GADV+ D LH A G+Y +LL+ A DL + TPLH
Sbjct: 64 ADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTR 123
Query: 287 KNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTR 346
+ +LLL + A P ++ +K+ L Y H L ++++
Sbjct: 124 HRSPKCLALLLKFMA-PGEVDTQDKNK-----QTALHWSAYYNNPEHVKLLIKHDSNI-- 175
Query: 347 IKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGAN---INEKTKEFLTP 403
+ V K P LH AA P +L +N + E TP
Sbjct: 176 -----GIPDVEGKIP------LHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTP 224
Query: 404 LHVASEKAHNDVVEVVVKHEA-KVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNII 462
LH A + VV+V+ +E+ + + DNL +T LH AA GH Q LLL I
Sbjct: 225 LHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIP 284
Query: 463 S-LQGFTALQMGN-----ENVQQLLQEGISLGNSEADRQ--LLEAAKAGDVETVKKLCTV 514
S QG T L E V+ L+ +S+ + + + AA G + ++ + ++
Sbjct: 285 SDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSL 344
Query: 515 QS---VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGH 571
+S +N D G T LH AA VS V+ LL++ A V A D PL AC GH
Sbjct: 345 KSDIDINMADKYG--GTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGH 402
Query: 572 YEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLD- 630
+V + L+K GA V++ D + LH AA G ++C++L+++ +P ++ G TPL
Sbjct: 403 KDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQC 462
Query: 631 -------------LVKDGDTDIQDLLRGDAALLDAAKKGCLARVK-KLSSPDNVNCRDTQ 676
+ + D +IQD G AL + G L +K L N +
Sbjct: 463 AAYGGYINCMAVLMENNADPNIQD-KEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENN 521
Query: 677 GRHSTPLHLAAGYNNLEVAEYLLQHGA 703
TPL A EV +++L+HGA
Sbjct: 522 EERYTPLDYALLGERHEVIQFMLEHGA 548
Score = 134 bits (338), Expect = 4e-31
Identities = 128/454 (28%), Positives = 203/454 (44%), Gaps = 53/454 (11%)
Query: 359 KHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEV 418
K + TALH AA + +LLL + AN +K E +TPLH+ + + +
Sbjct: 76 KTDHSQRTALHLAAQKG---NYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLAL 132
Query: 419 VVKHEA--KVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN 476
++K A +V+ D QT+LH +AY + + +LL+ + + I ++G L +
Sbjct: 133 LLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANH 192
Query: 477 VQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGY 536
+ R +L+AA T +N +D EGR TPLHFA
Sbjct: 193 KDPSAVHTV--------RCILDAAP-----------TESLLNWQDYEGR--TPLHFAVAD 231
Query: 537 NRVSVVEYLLQH-GADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV-ADLWKFT 594
V+VV+ L + ++ + D PLH A GH ++ LL++ + +D T
Sbjct: 232 GNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGAT 291
Query: 595 PLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAK 654
PLH AA E K+ L+H + VKD D+D++ G + + AA
Sbjct: 292 PLHYAAQSNFAETVKVFLKHPS---------------VKD-DSDLE----GRTSFMWAAG 331
Query: 655 KGC---LARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKG 711
KG L + L S ++N D G T LH AA ++ + LL++ A V+A D
Sbjct: 332 KGSDDVLRTMLSLKSDIDINMADKYG--GTALHAAALSGHVSTVKLLLENNAQVDATDVM 389
Query: 712 GLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP 771
PL A GH DV LIK A V+ D+ + LH AA G +C +L+ + +P
Sbjct: 390 KHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINP 449
Query: 772 TLKNQEGQTPLDLVSADDVSALLTAAMPPSALPS 805
+++ G+TPL + + M +A P+
Sbjct: 450 NVQDYAGRTPLQCAAYGGYINCMAVLMENNADPN 483
Score = 123 bits (308), Expect = 1e-27
Identities = 145/566 (25%), Positives = 233/566 (41%), Gaps = 72/566 (12%)
Query: 25 ARELFEACRNGDVERVKRLVTPEKV--NSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGA 82
A ++ A NGD ++RL+ + D GR TPL + R D + LL+ GA
Sbjct: 15 ASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGR--TPLMYCVLADRLDCADALLKAGA 72
Query: 83 NVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIV 142
+V D LH A G+ + LLL A+ +D TPLH + + C+
Sbjct: 73 DVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLH-LTTRHRSPKCLA 131
Query: 143 LLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNV 202
LL P V T + K L + N + + LL +
Sbjct: 132 LLLKFMAP------------------GEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDS 173
Query: 203 NCHASDGRKSTPLHLAAGY---NRVKIVQLLLQHGAD---VHAKDKGDLVPLHNACSYGH 256
N D PLH AA + + V V+ +L ++ +D PLH A + G+
Sbjct: 174 NIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGN 233
Query: 257 YEVTELLVKHGAC-VNAMDLWQFTPLHEAASKNRVEVCSLLL-----------SYGADPT 304
V ++L + +C + + D TPLH AA ++ LLL S GA P
Sbjct: 234 VTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATP- 292
Query: 305 LLNCHNKSAIDLAPT-------PQLKERLAYEFKGHSLLQAAREAD-----VTRIKKHLS 352
H + + A T P +K+ E + + A + +D + +K +
Sbjct: 293 ---LHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDID 349
Query: 353 LEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAH 412
+ M + + TALH AA S + +LLL A ++ TPL A E H
Sbjct: 350 INMAD----KYGGTALHAAALSGH---VSTVKLLLENNAQVDATDVMKHTPLFRACEMGH 402
Query: 413 NDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQM 472
DV++ ++K A+V+ +D G + LH AA G+ C++L+ +PN+ G T LQ
Sbjct: 403 KDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQC 462
Query: 473 ----GNENVQQLLQEG---ISLGNSEADRQLLEAAKAGDVETVKKLCTVQSV-NCRDIEG 524
G N +L E ++ + E L + G ++ +K L + N +
Sbjct: 463 AAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNE 522
Query: 525 RQSTPLHFAAGYNRVSVVEYLLQHGA 550
+ TPL +A R V++++L+HGA
Sbjct: 523 ERYTPLDYALLGERHEVIQFMLEHGA 548
Score = 110 bits (276), Expect = 6e-24
Identities = 114/410 (27%), Positives = 181/410 (44%), Gaps = 59/410 (14%)
Query: 45 TPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQ-NGANVQARDDGGLIPLHNACSFGH 103
T +N +D GR TPLHFA G VV+ L N+ + D+ PLH A GH
Sbjct: 210 TESLLNWQDYEGR--TPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGH 267
Query: 104 AEVVNLLL-RHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALD 162
A++V+LLL R+ + D+ TPLH AA + V L+H + + +GRT+
Sbjct: 268 AQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFM 327
Query: 163 LADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYN 222
A D++L + M++L + +++N +D T LH AA
Sbjct: 328 WAAGKGS---------DDVLRT--------MLSLKSDIDINM--ADKYGGTALHAAALSG 368
Query: 223 RVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLH 282
V V+LLL++ A V A D PL AC GH +V + L+K GA V+ +D + LH
Sbjct: 369 HVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLH 428
Query: 283 EAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREA 342
AA +VC +L+ +P + ++ G + LQ A
Sbjct: 429 WAALGGNADVCQILIENKINPNV----------------------QDYAGRTPLQCAAYG 466
Query: 343 DVTRIKKHLSLEMVNFKHPQTHE----TALHCAAASPYPKRKQICELLLRKGA--NINEK 396
+++ M N P + TALH + + Y +LLL A N E
Sbjct: 467 GYINC---MAVLMENNADPNIQDKEGRTALHWSCNNGY---LDAIKLLLDFAAFPNQMEN 520
Query: 397 TKEFLTPLHVASEKAHNDVVEVVVKHEA-KVNALDNLGQTSLHRAAYCGH 445
+E TPL A ++V++ +++H A + A+ ++ + +A Y G+
Sbjct: 521 NEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKI-QAVYKGY 569
Score = 58.2 bits (139), Expect = 5e-08
Identities = 43/137 (31%), Positives = 67/137 (48%), Gaps = 6/137 (4%)
Query: 16 AAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNS--RDTAGRKSTPLHFAAGFGRKDV 73
A + V+ L G V +++ K+N +D AGR TPL AA G +
Sbjct: 414 ARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGR--TPLQCAAYGGYINC 471
Query: 74 VEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDN--WNYTPLHEA 131
+ L++N A+ +D G LH +C+ G+ + + LLL A PN +N YTPL A
Sbjct: 472 MAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYA 531
Query: 132 AIKGKIDVCIVLLQHGA 148
+ + +V +L+HGA
Sbjct: 532 LLGERHEVIQFMLEHGA 548
Score = 47.0 bits (110), Expect = 1e-04
Identities = 36/96 (37%), Positives = 45/96 (46%), Gaps = 3/96 (3%)
Query: 708 QDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAH 767
+D+ G PL +D A L+K A VN TD T LH AAQKG + LLL
Sbjct: 44 EDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTR 103
Query: 768 GADPTLKNQEGQTPLDLVS---ADDVSALLTAAMPP 800
A+ K+ E TPL L + + ALL M P
Sbjct: 104 RANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAP 139
Score = 42.4 bits (98), Expect = 0.003
Identities = 32/97 (32%), Positives = 42/97 (43%)
Query: 681 TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNA 740
TPL + L+ A+ LL+ GADVN D LH AA G+ LL+ A
Sbjct: 50 TPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQ 109
Query: 741 TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQE 777
D TPLH + + ALLL A + Q+
Sbjct: 110 KDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQD 146
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 139 bits (349), Expect = 2e-32
Identities = 153/567 (26%), Positives = 238/567 (41%), Gaps = 52/567 (9%)
Query: 167 SAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKI 226
S + G ++ +A +G++ + L+ + D TPL +R+
Sbjct: 4 SENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDC 63
Query: 227 VQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAAS 286
LL+ GADV+ D LH A G+Y +LL+ A DL + TPLH
Sbjct: 64 ADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTR 123
Query: 287 KNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTR 346
+ +LLL + A P ++ +K+ L Y H L ++++
Sbjct: 124 HRSPKCLALLLKFMA-PGEVDTQDKNK-----QTALHWSAYYNNPEHVKLLIKHDSNI-- 175
Query: 347 IKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGAN---INEKTKEFLTP 403
+ V K P LH AA P +L +N + E TP
Sbjct: 176 -----GIPDVEGKIP------LHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTP 224
Query: 404 LHVASEKAHNDVVEVVVKHEA-KVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNII 462
LH A + VV+V+ +E+ + + DNL +T LH AA GH Q LLL I
Sbjct: 225 LHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIP 284
Query: 463 S-LQGFTALQMGN-----ENVQQLLQEGISLGNSEADRQ--LLEAAKAGDVETVKKLCTV 514
S QG T L E V+ L+ +S+ + + + AA G + ++ + ++
Sbjct: 285 SDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSL 344
Query: 515 QS---VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGH 571
+S +N D G T LH AA VS V+ LL++ A V A D PL AC GH
Sbjct: 345 KSDIDINMADKYG--GTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGH 402
Query: 572 YEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLD- 630
+V + L+K GA V++ D + LH AA G ++C++L+++ +P ++ G TPL
Sbjct: 403 KDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQC 462
Query: 631 -------------LVKDGDTDIQDLLRGDAALLDAAKKGCLARVK-KLSSPDNVNCRDTQ 676
+ + D +IQD G AL + G L +K L N +
Sbjct: 463 AAYGGYINCMAVLMENNADPNIQD-KEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENN 521
Query: 677 GRHSTPLHLAAGYNNLEVAEYLLQHGA 703
TPL A EV +++L+HGA
Sbjct: 522 EERYTPLDYALLGERHEVIQFMLEHGA 548
Score = 134 bits (338), Expect = 4e-31
Identities = 128/454 (28%), Positives = 203/454 (44%), Gaps = 53/454 (11%)
Query: 359 KHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEV 418
K + TALH AA + +LLL + AN +K E +TPLH+ + + +
Sbjct: 76 KTDHSQRTALHLAAQKG---NYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLAL 132
Query: 419 VVKHEA--KVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN 476
++K A +V+ D QT+LH +AY + + +LL+ + + I ++G L +
Sbjct: 133 LLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANH 192
Query: 477 VQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGY 536
+ R +L+AA T +N +D EGR TPLHFA
Sbjct: 193 KDPSAVHTV--------RCILDAAP-----------TESLLNWQDYEGR--TPLHFAVAD 231
Query: 537 NRVSVVEYLLQH-GADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV-ADLWKFT 594
V+VV+ L + ++ + D PLH A GH ++ LL++ + +D T
Sbjct: 232 GNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGAT 291
Query: 595 PLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAK 654
PLH AA E K+ L+H + VKD D+D++ G + + AA
Sbjct: 292 PLHYAAQSNFAETVKVFLKHPS---------------VKD-DSDLE----GRTSFMWAAG 331
Query: 655 KGC---LARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKG 711
KG L + L S ++N D G T LH AA ++ + LL++ A V+A D
Sbjct: 332 KGSDDVLRTMLSLKSDIDINMADKYG--GTALHAAALSGHVSTVKLLLENNAQVDATDVM 389
Query: 712 GLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP 771
PL A GH DV LIK A V+ D+ + LH AA G +C +L+ + +P
Sbjct: 390 KHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINP 449
Query: 772 TLKNQEGQTPLDLVSADDVSALLTAAMPPSALPS 805
+++ G+TPL + + M +A P+
Sbjct: 450 NVQDYAGRTPLQCAAYGGYINCMAVLMENNADPN 483
Score = 123 bits (308), Expect = 1e-27
Identities = 145/566 (25%), Positives = 233/566 (41%), Gaps = 72/566 (12%)
Query: 25 ARELFEACRNGDVERVKRLVTPEKV--NSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGA 82
A ++ A NGD ++RL+ + D GR TPL + R D + LL+ GA
Sbjct: 15 ASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGR--TPLMYCVLADRLDCADALLKAGA 72
Query: 83 NVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIV 142
+V D LH A G+ + LLL A+ +D TPLH + + C+
Sbjct: 73 DVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLH-LTTRHRSPKCLA 131
Query: 143 LLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNV 202
LL P V T + K L + N + + LL +
Sbjct: 132 LLLKFMAP------------------GEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDS 173
Query: 203 NCHASDGRKSTPLHLAAGY---NRVKIVQLLLQHGAD---VHAKDKGDLVPLHNACSYGH 256
N D PLH AA + + V V+ +L ++ +D PLH A + G+
Sbjct: 174 NIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGN 233
Query: 257 YEVTELLVKHGAC-VNAMDLWQFTPLHEAASKNRVEVCSLLL-----------SYGADPT 304
V ++L + +C + + D TPLH AA ++ LLL S GA P
Sbjct: 234 VTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATP- 292
Query: 305 LLNCHNKSAIDLAPT-------PQLKERLAYEFKGHSLLQAAREAD-----VTRIKKHLS 352
H + + A T P +K+ E + + A + +D + +K +
Sbjct: 293 ---LHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDID 349
Query: 353 LEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAH 412
+ M + + TALH AA S + +LLL A ++ TPL A E H
Sbjct: 350 INMAD----KYGGTALHAAALSGH---VSTVKLLLENNAQVDATDVMKHTPLFRACEMGH 402
Query: 413 NDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQM 472
DV++ ++K A+V+ +D G + LH AA G+ C++L+ +PN+ G T LQ
Sbjct: 403 KDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQC 462
Query: 473 ----GNENVQQLLQEG---ISLGNSEADRQLLEAAKAGDVETVKKLCTVQSV-NCRDIEG 524
G N +L E ++ + E L + G ++ +K L + N +
Sbjct: 463 AAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNE 522
Query: 525 RQSTPLHFAAGYNRVSVVEYLLQHGA 550
+ TPL +A R V++++L+HGA
Sbjct: 523 ERYTPLDYALLGERHEVIQFMLEHGA 548
Score = 110 bits (276), Expect = 6e-24
Identities = 114/410 (27%), Positives = 181/410 (44%), Gaps = 59/410 (14%)
Query: 45 TPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQ-NGANVQARDDGGLIPLHNACSFGH 103
T +N +D GR TPLHFA G VV+ L N+ + D+ PLH A GH
Sbjct: 210 TESLLNWQDYEGR--TPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGH 267
Query: 104 AEVVNLLL-RHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALD 162
A++V+LLL R+ + D+ TPLH AA + V L+H + + +GRT+
Sbjct: 268 AQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFM 327
Query: 163 LADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYN 222
A D++L + M++L + +++N +D T LH AA
Sbjct: 328 WAAGKGS---------DDVLRT--------MLSLKSDIDINM--ADKYGGTALHAAALSG 368
Query: 223 RVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLH 282
V V+LLL++ A V A D PL AC GH +V + L+K GA V+ +D + LH
Sbjct: 369 HVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLH 428
Query: 283 EAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREA 342
AA +VC +L+ +P + ++ G + LQ A
Sbjct: 429 WAALGGNADVCQILIENKINPNV----------------------QDYAGRTPLQCAAYG 466
Query: 343 DVTRIKKHLSLEMVNFKHPQTHE----TALHCAAASPYPKRKQICELLLRKGA--NINEK 396
+++ M N P + TALH + + Y +LLL A N E
Sbjct: 467 GYINC---MAVLMENNADPNIQDKEGRTALHWSCNNGY---LDAIKLLLDFAAFPNQMEN 520
Query: 397 TKEFLTPLHVASEKAHNDVVEVVVKHEA-KVNALDNLGQTSLHRAAYCGH 445
+E TPL A ++V++ +++H A + A+ ++ + +A Y G+
Sbjct: 521 NEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKI-QAVYKGY 569
Score = 58.2 bits (139), Expect = 5e-08
Identities = 43/137 (31%), Positives = 67/137 (48%), Gaps = 6/137 (4%)
Query: 16 AAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNS--RDTAGRKSTPLHFAAGFGRKDV 73
A + V+ L G V +++ K+N +D AGR TPL AA G +
Sbjct: 414 ARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGR--TPLQCAAYGGYINC 471
Query: 74 VEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDN--WNYTPLHEA 131
+ L++N A+ +D G LH +C+ G+ + + LLL A PN +N YTPL A
Sbjct: 472 MAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYA 531
Query: 132 AIKGKIDVCIVLLQHGA 148
+ + +V +L+HGA
Sbjct: 532 LLGERHEVIQFMLEHGA 548
Score = 47.0 bits (110), Expect = 1e-04
Identities = 36/96 (37%), Positives = 45/96 (46%), Gaps = 3/96 (3%)
Query: 708 QDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAH 767
+D+ G PL +D A L+K A VN TD T LH AAQKG + LLL
Sbjct: 44 EDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTR 103
Query: 768 GADPTLKNQEGQTPLDLVS---ADDVSALLTAAMPP 800
A+ K+ E TPL L + + ALL M P
Sbjct: 104 RANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAP 139
Score = 42.4 bits (98), Expect = 0.003
Identities = 32/97 (32%), Positives = 42/97 (43%)
Query: 681 TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNA 740
TPL + L+ A+ LL+ GADVN D LH AA G+ LL+ A
Sbjct: 50 TPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQ 109
Query: 741 TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQE 777
D TPLH + + ALLL A + Q+
Sbjct: 110 KDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQD 146
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 137 bits (346), Expect = 5e-32
Identities = 114/366 (31%), Positives = 172/366 (46%), Gaps = 34/366 (9%)
Query: 381 QICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRA 440
++ LLL GAN++ ++ LTPL A+ + +V ++ K AKV+ LD GQ +L A
Sbjct: 899 EMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHA 958
Query: 441 AYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAA 500
A GHL+ + L+ CD + Q + + +QQ L S+G +E LL+
Sbjct: 959 ALRGHLEVVKFLIQ--CDWTMAGQQ--QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLP 1014
Query: 501 KAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGL 560
+ + E + +N D + T L AAG ++ V LL+ GA V ++ G
Sbjct: 1015 EKDEEEVERA-----QINSFDSLWGE-TALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGA 1068
Query: 561 VPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTK 620
VPL + GH+++ +LL+ HGA VN+AD TPL AA++G LL GA
Sbjct: 1069 VPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIAL 1128
Query: 621 KNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHS 680
+++G T AL A KG L+ V+ L DN D ++
Sbjct: 1129 MDKEGLT--------------------ALSWACLKGHLSVVRSL--VDNGAATDHADKNG 1166
Query: 681 -TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVN 739
TPL LAA Y + EV ++L+ HGA + D G+ PL A + V L+K A +
Sbjct: 1167 RTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIG 1226
Query: 740 ATDKWA 745
WA
Sbjct: 1227 PA-TWA 1231
Score = 110 bits (276), Expect = 6e-24
Identities = 124/427 (29%), Positives = 175/427 (40%), Gaps = 75/427 (17%)
Query: 376 YPKRKQICELLLRKGANINEKTKEFLTP--LHVASEKAHNDVVEVVVKHEAKVNALDNLG 433
Y ++ LL+ GANIN +T+ L V S + ++V ++++ A V+A G
Sbjct: 859 YTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESG 918
Query: 434 QTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEAD 493
T L AA G+L LL + + G AL V L+ G+ E
Sbjct: 919 LTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL------VHAALR-----GHLEVV 967
Query: 494 RQLLEA--AKAGDVETV-KKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGA 550
+ L++ AG + V KK +Q L AA +V YLL
Sbjct: 968 KFLIQCDWTMAGQQQGVFKKSHAIQQA------------LIAAASMGYTEIVSYLL---- 1011
Query: 551 DVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKL 610
D+ KD E V+ + + LW T L AA +GK E+C+L
Sbjct: 1012 DLPEKD-------------------EEEVERAQINSFDSLWGETALTAAAGRGKLEVCRL 1052
Query: 611 LLQHGADPTKKNRDGNTPL-DLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDN 669
LL+ GA + NR G PL V+ G I DLL L+ +
Sbjct: 1053 LLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLL--------------------LTHGAD 1092
Query: 670 VNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAA 729
VN D QGR TPL +AA +L ++LL GA + DK GL L A GH+ V
Sbjct: 1093 VNMADKQGR--TPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVR 1150
Query: 730 LLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLD-LVSAD 788
L+ A + DK TPL AA G ++ L+ HGA + G PLD V
Sbjct: 1151 SLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCR 1210
Query: 789 DVSALLT 795
+ S ++T
Sbjct: 1211 NTSVVVT 1217
Score = 103 bits (258), Expect = 7e-22
Identities = 114/428 (26%), Positives = 173/428 (40%), Gaps = 60/428 (14%)
Query: 194 MALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACS 253
+ +L N+N + L + + ++V LLL+ GA+V A + L PL A +
Sbjct: 868 LLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAA 927
Query: 254 YGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHN--- 310
G+ + LL K A V+ +D L AA + +EV L+ D T+
Sbjct: 928 AGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQ--CDWTMAGQQQGVF 985
Query: 311 ------KSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTH 364
+ A+ A + E ++Y L E D +++ +N
Sbjct: 986 KKSHAIQQALIAAASMGYTEIVSY-------LLDLPEKDEEEVER----AQINSFDSLWG 1034
Query: 365 ETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEA 424
ETAL AA + ++C LLL +GA + + + PL + H +V++++ H A
Sbjct: 1035 ETALTAAAGR---GKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGA 1091
Query: 425 KVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEG 484
VN D G+T L AA GHL T LL+ G ++ +G TAL
Sbjct: 1092 DVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSW-----------A 1140
Query: 485 ISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEY 544
G+ R L++ A D D GR TPL AA Y VV++
Sbjct: 1141 CLKGHLSVVRSLVDNGAATD--------------HADKNGR--TPLDLAAFYGDAEVVQF 1184
Query: 545 LLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGK 604
L+ HGA + D G+ PL A + V L+K GA K P A A K
Sbjct: 1185 LVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGA--------KIGPATWAMATSK 1236
Query: 605 YEICKLLL 612
+I +LL
Sbjct: 1237 PDIMIILL 1244
Score = 94.0 bits (232), Expect = 8e-19
Identities = 102/422 (24%), Positives = 161/422 (38%), Gaps = 89/422 (21%)
Query: 49 VNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVN 108
+N R + L + G ++V LL+ GANV A + GL PL A + G+ +V
Sbjct: 876 INYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVV 935
Query: 109 LLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSA 168
LL + A + D L AA++G ++V L+Q D +
Sbjct: 936 LLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQ------------------CDWTM 977
Query: 169 KAVLTGEYKKDELLE----SARSGNEEKMMALLTPLNVNCHASDGRKS----------TP 214
G +KK ++ +A S ++++ L L R T
Sbjct: 978 AGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETA 1037
Query: 215 LHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMD 274
L AAG ++++ +LLL+ GA V ++ VPL + GH+++ +LL+ HGA VN D
Sbjct: 1038 LTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMAD 1097
Query: 275 LWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHS 334
TPL AAS+ + LL+ GA L++ +A+ A
Sbjct: 1098 KQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWA----------------- 1140
Query: 335 LLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANIN 394
+K HLS + L+ GA +
Sbjct: 1141 -----------CLKGHLS-----------------------------VVRSLVDNGAATD 1160
Query: 395 EKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLS 454
K TPL +A+ +VV+ +V H A + +D G L RA C + LL
Sbjct: 1161 HADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLK 1220
Query: 455 YG 456
G
Sbjct: 1221 KG 1222
Score = 94.0 bits (232), Expect = 8e-19
Identities = 81/263 (30%), Positives = 118/263 (44%), Gaps = 34/263 (12%)
Query: 36 DVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPL 95
D E V+R ++NS D+ + T L AAG G+ +V LL+ GA V + G +PL
Sbjct: 1017 DEEEVERA----QINSFDSLWGE-TALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPL 1071
Query: 96 HNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNT 155
+ GH ++V+LLL HGAD N D TPL AA +G + LL GA + +
Sbjct: 1072 FSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDK 1131
Query: 156 DGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPL 215
+G TAL A G+ + +L+ HA D TPL
Sbjct: 1132 EGLTALSWA--------------------CLKGHLSVVRSLVDNGAATDHA-DKNGRTPL 1170
Query: 216 HLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDL 275
LAA Y ++VQ L+ HGA + D + PL A + V L+K GA +
Sbjct: 1171 DLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIG---- 1226
Query: 276 WQFTPLHEAASKNRVEVCSLLLS 298
P A + ++ ++ +LLS
Sbjct: 1227 ----PATWAMATSKPDIMIILLS 1245
Score = 80.1 bits (196), Expect = 1e-14
Identities = 80/271 (29%), Positives = 118/271 (43%), Gaps = 40/271 (14%)
Query: 48 KVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHN-------ACS 100
KV+ D G+ + L AA G +VV++L+Q + + G H A S
Sbjct: 943 KVDHLDKNGQCA--LVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAAS 1000
Query: 101 FGHAEVVNLLLR---------HGADPNARDN-WNYTPLHEAAIKGKIDVCIVLLQHGAEP 150
G+ E+V+ LL A N+ D+ W T L AA +GK++VC +LL+ GA
Sbjct: 1001 MGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAA- 1059
Query: 151 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGR 210
+A P+ + + L + R G+ + + LLT + + +D +
Sbjct: 1060 ------------VAQPNRRGAVP-------LFSTVRQGHWQIVDLLLTH-GADVNMADKQ 1099
Query: 211 KSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACV 270
TPL +AA + V LL GA + DK L L AC GH V LV +GA
Sbjct: 1100 GRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAAT 1159
Query: 271 NAMDLWQFTPLHEAASKNRVEVCSLLLSYGA 301
+ D TPL AA EV L+ +GA
Sbjct: 1160 DHADKNGRTPLDLAAFYGDAEVVQFLVDHGA 1190
>gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform 1
[Homo sapiens]
Length = 1170
Score = 136 bits (342), Expect = 1e-31
Identities = 194/795 (24%), Positives = 300/795 (37%), Gaps = 117/795 (14%)
Query: 46 PEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAE 105
P K+N D G L A + + L+ + A+V D G LH G
Sbjct: 246 PGKLNEADHNG--DLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLF 303
Query: 106 VVNLLLRHGADPNARD-NWNYTPLHEAAI----KGKIDVCI-------VLLQHGAEPTIR 153
L+++GA NA TPLH A+ K DV LLQ GA P ++
Sbjct: 304 AATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQ 363
Query: 154 NTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGR--- 210
++ GRT L ++ + + + + + L+ +E L ++ +
Sbjct: 364 DSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPF 423
Query: 211 KSTPLHLAAGYNRVKIVQLLLQHGADVHAKDK--GDLVPLHNACSYGHYEVTELLVKHGA 268
+ P+ ++ L+Q G+ A D G+ + L A G+ L +GA
Sbjct: 424 EDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCL-LQRAAGAGNEAAALFLATNGA 482
Query: 269 CVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAY 328
VN + W TPLH A + + LL GA+P L Q +E L
Sbjct: 483 HVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNL---------------QTEEALPL 527
Query: 329 EFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLR 388
+ SL A HL +T LH A A +P + ++L
Sbjct: 528 PKEAASLTSLADSV-------HL-------------QTPLHMAIAYNHP---DVVSVILE 564
Query: 389 KGANINEKTKEFL-------------TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQT 435
+ AN T T L +A + + ++ A +N + GQT
Sbjct: 565 QKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQT 624
Query: 436 SLHRAAYCGHLQTCRLLLSYGCDPNIISLQ-GFTALQMGNENVQQLLQEGISLGNS---- 490
LH A ++ LL + D N+ Q G TALQ+ N L+ + I +
Sbjct: 625 LLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSV 684
Query: 491 --EADRQLLEAAKAGDVETVKKLCTVQSVNCR----DIEGRQSTPLHFAAGYNRVSVVEY 544
E L A A ++E + + G T LH A N +
Sbjct: 685 PDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACF 744
Query: 545 LLQHGADVHA------------KDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWK 592
L++ G DV++ + + G PLH A S+G E + L++ GA VN D
Sbjct: 745 LIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEG 804
Query: 593 FTPLHEAAAKGKYEICKLLLQH-GADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLD 651
TP+H A + I +LL+ H ++R G TP A+
Sbjct: 805 RTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPF----------------ACAMTF 848
Query: 652 AAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNA--QD 709
K A +K+ S D +GR+ LH+A +++E +L+ A+VN+ QD
Sbjct: 849 KNNKSAEAILKRESGA--AEQVDNKGRNF--LHVAVQNSDIESVLFLISVHANVNSRVQD 904
Query: 710 KGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGA 769
L PLH A G + L+ A VN K T LH AAQ+ +C++LL +G
Sbjct: 905 ASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGV 964
Query: 770 DPTLKNQEGQTPLDL 784
D ++ G L L
Sbjct: 965 DFAAVDENGNNALHL 979
Score = 129 bits (324), Expect = 2e-29
Identities = 193/799 (24%), Positives = 291/799 (36%), Gaps = 152/799 (19%)
Query: 62 LHFAAGFGRKDVVEYLLQNGANVQARDDGGL-IPLHNACSFGH-----------AEVVNL 109
LH G +L++NGA V A G PLH + A++
Sbjct: 293 LHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEA 352
Query: 110 LLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ-HGAEPTIRNTDGRTALDLADPSA 168
LL+ GA+PN +D+ TPLH + + G V LLQ + +++ +G TAL LA
Sbjct: 353 LLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHI 412
Query: 169 KAVLTGEYK--KDELLESARSGNEEKMMALLTPLNVNCHASD-GRKSTPLHLAAGYNRVK 225
+D + + S +E A L + A D + L AAG
Sbjct: 413 TVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEA 472
Query: 226 IVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVN-------------- 271
L +GA V+ ++K PLH AC +G +T L++ GA N
Sbjct: 473 AALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAA 532
Query: 272 -----AMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKER- 325
A + TPLH A + N +V S++L A+ H + + + P LK+
Sbjct: 533 SLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANAL----HATNNLQIIPDFSLKDSR 588
Query: 326 ---------------LAYEFKG----------------HSLLQAAREADVTRIKKHLSLE 354
+A + G H +Q + +H +
Sbjct: 589 DQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQA-- 646
Query: 355 MVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHND 414
+N Q ETAL A + P + + + +GA+++ ++ PL +A D
Sbjct: 647 DINVSRTQDGETALQLAIRNQLPL---VVDAICTRGADMSVPDEKGNPPLWLALANNLED 703
Query: 415 VVEVVVKHEAKVNALD----NLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTAL 470
+ +V+H QT LHRA + T L+ GCD N G
Sbjct: 704 IASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPG---- 759
Query: 471 QMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPL 530
N E + E A+ G TPL
Sbjct: 760 -----------------ANGEGE----EEARDGQ-----------------------TPL 775
Query: 531 HFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAV-VNVAD 589
H AA + V+ LL+ GA+V+A+D G P+H A S H + +LLV H + +NV D
Sbjct: 776 HLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRD 835
Query: 590 LWKFTPLHEAAAKGKYEICKLLL--QHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDA 647
TP A + + +L + GA N+ N V++ D + L
Sbjct: 836 RQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFL---- 891
Query: 648 ALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNA 707
+S NVN R TPLHLA + + LL GA VN
Sbjct: 892 ----------------ISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNE 935
Query: 708 QDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAH 767
K LH AA + ++L++ A D+ LH A GR +LL
Sbjct: 936 LTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTE 995
Query: 768 -GADPTLKNQEGQTPLDLV 785
D N GQ+PL ++
Sbjct: 996 CTVDAEAFNLRGQSPLHIL 1014
Score = 125 bits (314), Expect = 2e-28
Identities = 203/831 (24%), Positives = 319/831 (38%), Gaps = 121/831 (14%)
Query: 28 LFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRK-----------DVVEY 76
L + + GD+ L+ + T G + TPLH A + K + E
Sbjct: 293 LHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEA 352
Query: 77 LLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLR-HGADPNARDNWNYTPLHEAAIKG 135
LLQ GAN +D G PLH + G+ V + LL+ D +D+ T L A
Sbjct: 353 LLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHI 412
Query: 136 KIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDE--------LLESARS 187
+ + P + T+ D +A+ + G + L +A +
Sbjct: 413 TVSSDQSVNPFEDVPVVNG----TSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGA 468
Query: 188 GNEEKMMALLTPLNVNCHASDGRK--STPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDL 245
GNE + L T H + K TPLH A + + LLQ GA+ + + + L
Sbjct: 469 GNEAAALFLATN---GAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEAL 525
Query: 246 -------------------VPLHNACSYGHYEVTELLVKHGA-CVNAMDLWQFTPLHEAA 285
PLH A +Y H +V ++++ A ++A + Q P
Sbjct: 526 PLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLK 585
Query: 286 SKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVT 345
V L L G H +A L + + ++ G +LL A + +
Sbjct: 586 DSRDQTVLGLALWTG-------MHTIAAQLLGSGAAINDTMS---DGQTLLHMAIQRQDS 635
Query: 346 RIKKHLSLEM--VNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTP 403
+ L +N Q ETAL A + P + + + +GA+++ ++ P
Sbjct: 636 KSALFLLEHQADINVSRTQDGETALQLAIRNQLP---LVVDAICTRGADMSVPDEKGNPP 692
Query: 404 LHVASEKAHNDVVEVVVKHEAKVNAL----DNLGQTSLHRAAYCGHLQTCRLLLSYGCDP 459
L +A D+ +V+H QT LHRA + T L+ GCD
Sbjct: 693 LWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDV 752
Query: 460 NIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTV-QSVN 518
N G A G E + + L AA G ETV+ L +VN
Sbjct: 753 NSPRQPG--ANGEGEEEAR------------DGQTPLHLAASWGLEETVQCLLEFGANVN 798
Query: 519 CRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVH--AKDKGGLVPLHNACSYGHYEVAE 576
+D EGR TP+H A +++ L+ H D+H +D+ GL P A ++ + + AE
Sbjct: 799 AQDAEGR--TPIHVAISSQHGVIIQLLVSH-PDIHLNVRDRQGLTPFACAMTFKNNKSAE 855
Query: 577 LLVKH--GAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGN--TPLDLV 632
++K GA V + + LH A E L+ A+ + +D + TPL L
Sbjct: 856 AILKRESGAAEQVDNKGR-NFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLA 914
Query: 633 KDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNL 692
++I ++R LL AK L + T LHLAA +
Sbjct: 915 VQAGSEI--IVRN--LLLAGAKVNELTK-----------------HRQTALHLAAQQDLP 953
Query: 693 EVAEYLLQHGADVNAQDKGGLIPLHNAASYGHV-DVAALLIKYNACVNATDKWAFTPLHE 751
+ LL++G D A D+ G LH A +G + ++ LL + A + +PLH
Sbjct: 954 TICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHI 1013
Query: 752 AAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSA 802
Q G+ A+ D L+ G PLD AD + LL A M +A
Sbjct: 1014 LGQYGKENAAAIF-----DLFLECMPGY-PLDKPDADGSTVLLLAYMKGNA 1058
Score = 96.7 bits (239), Expect = 1e-19
Identities = 133/516 (25%), Positives = 210/516 (40%), Gaps = 69/516 (13%)
Query: 27 ELFEACRNGDVERVKRLVTPEKVNSRDTAGRK---STPLHFAAGFGRKDVVEYLLQNGAN 83
EL + N +++ + L P++ S + TPLH A + DVV +L+ AN
Sbjct: 509 ELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKAN 568
Query: 84 -VQARDDGGLIP------------LHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHE 130
+ A ++ +IP L A G + LL GA N + T LH
Sbjct: 569 ALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHM 628
Query: 131 AAIKGKIDVCIVLLQHGAEPTIRNT-DGRTALDLADPSAKAVLTGEY--KKDELLESARS 187
A + + LL+H A+ + T DG TAL LA + ++ + ++
Sbjct: 629 AIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEK 688
Query: 188 GNEEKMMALL--------TPLNVNCHAS------DGRKSTPLHLAAGYNRVKIVQLLLQH 233
GN +AL T + C A+ G T LH A N L++
Sbjct: 689 GNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRS 748
Query: 234 GADVH------AKDKGD------LVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPL 281
G DV+ A +G+ PLH A S+G E + L++ GA VNA D TP+
Sbjct: 749 GCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPI 808
Query: 282 HEAASKNRVEVCSLLLSY-----------GADP--TLLNCHNKSAIDLAPTPQLKERLAY 328
H A S + LL+S+ G P + N + + +
Sbjct: 809 HVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQV 868
Query: 329 EFKGHSLLQAA-READVTRIKKHLSLEM-VNFKHPQTHE-TALHCAAASPYPKRKQICEL 385
+ KG + L A + +D+ + +S+ VN + + T LH A + + I
Sbjct: 869 DNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAG---SEIIVRN 925
Query: 386 LLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGH 445
LL GA +NE TK T LH+A+++ + V++++ A+D G +LH A G
Sbjct: 926 LLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGR 985
Query: 446 LQTCRLLLS-YGCDPNIISLQGFTAL----QMGNEN 476
L R+LL+ D +L+G + L Q G EN
Sbjct: 986 LNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKEN 1021
Score = 74.3 bits (181), Expect = 6e-13
Identities = 111/464 (23%), Positives = 178/464 (38%), Gaps = 46/464 (9%)
Query: 380 KQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLG--QTSL 437
+ I L+ A+++ K + LH ++ ++K+ A VNA LG +T L
Sbjct: 269 ESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAA-TLGAQETPL 327
Query: 438 HRAAYCGH-----------LQTCRLLLSYGCDPNIISLQGFTALQM----GNENV-QQLL 481
H A Q LL G +PN+ +G T L + GNE V QLL
Sbjct: 328 HLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLL 387
Query: 482 QEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSV 541
Q + D +L + + + + TV S + + + P+ ++ S
Sbjct: 388 Q------CKQLDLELKDHEGSTALWLAVQHITVSSD--QSVNPFEDVPVVNGTSFDENSF 439
Query: 542 VEYLLQHGADVHAKDKG-GLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAA 600
L+Q G+ A D G L A G+ A L +GA VN + W TPLH A
Sbjct: 440 AARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTAC 499
Query: 601 AKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAA------- 653
G + LLQ GA+P + + PL T + D + L A
Sbjct: 500 RHGLANLTAELLQQGANPNLQTEEA-LPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDV 558
Query: 654 -------KKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVN 706
K L L + + +D+ R T L LA +A LL GA +N
Sbjct: 559 VSVILEQKANALHATNNLQIIPDFSLKDS--RDQTVLGLALWTGMHTIAAQLLGSGAAIN 616
Query: 707 AQDKGGLIPLHNAASYGHVDVAALLIKYNACVNAT-DKWAFTPLHEAAQKGRTQLCALLL 765
G LH A A L+++ A +N + + T L A + + +
Sbjct: 617 DTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAIC 676
Query: 766 AHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPSCYKP 809
GAD ++ +++G PL L A+++ + + + +C+ P
Sbjct: 677 TRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGP 720
Score = 64.3 bits (155), Expect = 6e-10
Identities = 86/315 (27%), Positives = 120/315 (38%), Gaps = 64/315 (20%)
Query: 522 IEGRQSTPLHFAAGYNRVSVVE-YLLQHGADVHAK----DKGGLVPLHNACSYGHYEVAE 576
I+ + PLH A R VV YL++ + + K D G + L A S +A
Sbjct: 214 IKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIAT 273
Query: 577 LLVKH---------------------------------GAVVNVADLW-KFTPLHEAAAK 602
LV H GA VN A L + TPLH A
Sbjct: 274 TLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALY 333
Query: 603 GK-----------YEICKLLLQHGADPTKKNRDGNTPL--DLVKDGDTDIQDLLRG---D 646
+I + LLQ GA+P ++ G TPL ++ + LL+ D
Sbjct: 334 SSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLD 393
Query: 647 AALLDAAKKGCL---ARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGA 703
L D L + +SS +VN + P+ ++ A L+Q G+
Sbjct: 394 LELKDHEGSTALWLAVQHITVSSDQSVNPFE-----DVPVVNGTSFDENSFAARLIQRGS 448
Query: 704 DVNAQDKG-GLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCA 762
+A D G L AA G+ A L A VN +KW TPLH A + G L A
Sbjct: 449 HTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTA 508
Query: 763 LLLAHGADPTLKNQE 777
LL GA+P L+ +E
Sbjct: 509 ELLQQGANPNLQTEE 523
Score = 55.8 bits (133), Expect = 2e-07
Identities = 46/132 (34%), Positives = 61/132 (46%), Gaps = 2/132 (1%)
Query: 15 SAAAEAVEPAARE-LFEACRNGDVERVKRLVTPE-KVNSRDTAGRKSTPLHFAAGFGRKD 72
S AAE V+ R L A +N D+E V L++ VNSR K TPLH A G +
Sbjct: 862 SGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEI 921
Query: 73 VVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAA 132
+V LL GA V LH A + ++LL +G D A D LH A
Sbjct: 922 IVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAV 981
Query: 133 IKGKIDVCIVLL 144
+ G+++ VLL
Sbjct: 982 MHGRLNNIRVLL 993
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 130 bits (328), Expect = 6e-30
Identities = 133/434 (30%), Positives = 187/434 (43%), Gaps = 74/434 (17%)
Query: 294 SLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSL 353
SL LS+ +P S DL T K++L + A D +++ K L
Sbjct: 386 SLSLSFEREP--------STSDLGTTDVQKKKL---------VDAIVSGDTSKLMKILQP 428
Query: 354 EMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHN 413
+ V+ + + LH A + +++ + LL AN N + TPLH+A E+
Sbjct: 429 QDVDLAL-DSGASLLHLAVEAG---QEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVR 484
Query: 414 DVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFT----A 469
VVE+++ + VNA D T+LH AA G + RLLL N + +G T A
Sbjct: 485 GVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVA 544
Query: 470 LQMGNENVQQ-LLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQST 528
Q G EN+ + LL+ G+ + D L
Sbjct: 545 CQHGQENIVRILLRRGVDVSLQGKDAWL-------------------------------- 572
Query: 529 PLHFAAGYNRVSVVEYLL-QHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV 587
PLH+AA + +V+ L Q G V+A+ G PLH A GHY VA +L+ + VNV
Sbjct: 573 PLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNV 632
Query: 588 ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV-KDGDTDIQDLL--- 643
L TPLH AA G +LLL GA DG T L L ++G LL
Sbjct: 633 CSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEE 692
Query: 644 ------RG---DAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEV 694
RG AL AA G V++L S D ++ D QG + LHLAA + +
Sbjct: 693 KADVLARGPLNQTALHLAAAHGHSEVVEELVSADVIDLFDEQGLSA--LHLAAQGRHAQT 750
Query: 695 AEYLLQHGADVNAQ 708
E LL+HGA +N Q
Sbjct: 751 VETLLRHGAHINLQ 764
Score = 126 bits (317), Expect = 1e-28
Identities = 117/367 (31%), Positives = 168/367 (45%), Gaps = 39/367 (10%)
Query: 428 ALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN-----VQQLLQ 482
ALD+ G + LH A G + + LL +PN+ + +G T L M E V+ LL
Sbjct: 434 ALDS-GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLA 492
Query: 483 EGISLGNSEADR--QLLEAAKAGDVETVKKLCTVQ-SVNCRDIEGRQSTPLHFAAGYNRV 539
IS+ + D+ L AA+ GD + + L SVN D EGR TP+H A + +
Sbjct: 493 RKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGR--TPMHVACQHGQE 550
Query: 540 SVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKH-GAVVNVADLWKFTPLHE 598
++V LL+ G DV + K +PLH A GH + +LL K G VN L TPLH
Sbjct: 551 NIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHL 610
Query: 599 AAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKD-GDTDIQDLLRGDAALLDAAKKGC 657
AA +G Y + ++L+ +D + TPL + + G T LL A
Sbjct: 611 AAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGA--------- 661
Query: 658 LARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLH 717
K+ + D T LHLAA +L + L++ ADV A+ LH
Sbjct: 662 ---GKEAMTSDGY----------TALHLAARNGHLATVKLLVEEKADVLARGPLNQTALH 708
Query: 718 NAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGAD---PTLK 774
AA++GH +V L+ + ++ D+ + LH AAQ Q LL HGA +LK
Sbjct: 709 LAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLK 767
Query: 775 NQEGQTP 781
Q G P
Sbjct: 768 FQGGHGP 774
Score = 124 bits (311), Expect = 5e-28
Identities = 126/442 (28%), Positives = 194/442 (43%), Gaps = 64/442 (14%)
Query: 165 DPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRV 224
+PS + T + +K +L+++ SG+ K+M +L P +V+ G ++ LHLA +
Sbjct: 394 EPSTSDLGTTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSG--ASLLHLAVEAGQE 451
Query: 225 KIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEA 284
+ + LL + A+ + ++ PLH A V ELL+ VNA D Q+T LH A
Sbjct: 452 ECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFA 511
Query: 285 ASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADV 344
A LLL A ++ ++ + +A + + + R DV
Sbjct: 512 AQNGDESSTRLLLEKNASVNEVDFEGRTPMHVA--------CQHGQENIVRILLRRGVDV 563
Query: 345 TRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRK-GANINEKTKEFLTP 403
+ K L LH AA + I +LL ++ G ++N +T + TP
Sbjct: 564 SLQGKDAWLP-------------LHYAA---WQGHLPIVKLLAKQPGVSVNAQTLDGRTP 607
Query: 404 LHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIIS 463
LH+A+++ H V +++ + VN L QT LH AA GH T RLLL G ++
Sbjct: 608 LHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMT 667
Query: 464 LQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIE 523
G+TAL + AA+ G + TVK L ++ D+
Sbjct: 668 SDGYTALHL--------------------------AARNGHLATVKLLVEEKA----DVL 697
Query: 524 GR---QSTPLHFAAGYNRVSVVEYLLQHGADV-HAKDKGGLVPLHNACSYGHYEVAELLV 579
R T LH AA + VVE L+ ADV D+ GL LH A H + E L+
Sbjct: 698 ARGPLNQTALHLAAAHGHSEVVEELVS--ADVIDLFDEQGLSALHLAAQGRHAQTVETLL 755
Query: 580 KHGAVVNVADLWKFTPLHEAAA 601
+HGA +N+ L KF H AA
Sbjct: 756 RHGAHINLQSL-KFQGGHGPAA 776
Score = 114 bits (284), Expect = 7e-25
Identities = 97/291 (33%), Positives = 125/291 (42%), Gaps = 25/291 (8%)
Query: 499 AAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKG 558
A +AG E K L + + N R STPLH A VVE LL V+AKD+
Sbjct: 445 AVEAGQEECAKWLL-LNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDED 503
Query: 559 GLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADP 618
LH A G LL++ A VN D TP+H A G+ I ++LL+ G D
Sbjct: 504 QWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDV 563
Query: 619 TKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPD--NVNCRDTQ 676
+ + +D PL AA +G L VK L+ +VN +
Sbjct: 564 SLQGKDAWLPLHY--------------------AAWQGHLPIVKLLAKQPGVSVNAQTLD 603
Query: 677 GRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNA 736
GR TPLHLAA + VA L+ +DVN PLH AA GH A LL+ A
Sbjct: 604 GR--TPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGA 661
Query: 737 CVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSA 787
A +T LH AA+ G LL+ AD + QT L L +A
Sbjct: 662 GKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAA 712
Score = 108 bits (269), Expect = 4e-23
Identities = 109/382 (28%), Positives = 156/382 (40%), Gaps = 48/382 (12%)
Query: 20 AVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQ 79
A++ A L A G E K L+ N + R STPLH A + VVE LL
Sbjct: 434 ALDSGASLLHLAVEAGQEECAKWLLL-NNANPNLSNRRGSTPLHMAVERRVRGVVELLLA 492
Query: 80 NGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDV 139
+V A+D+ LH A G LLL A N D TP+H A G+ ++
Sbjct: 493 RKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENI 552
Query: 140 CIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTP 199
+LL+ G + +++ D L A + K++A
Sbjct: 553 VRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIV------------------KLLAKQPG 594
Query: 200 LNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEV 259
++VN DGR TPLHLAA ++ ++L+ +DV+ PLH A GH
Sbjct: 595 VSVNAQTLDGR--TPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTST 652
Query: 260 TELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPT 319
LL+ GA AM +T LH AA + LL+ AD N++A+ LA
Sbjct: 653 ARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAA 712
Query: 320 PQLKERLAYEFKGHS-LLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPK 378
GHS +++ ADV + L +ALH AA +
Sbjct: 713 -----------HGHSEVVEELVSADVIDLFDEQGL------------SALHLAAQG---R 746
Query: 379 RKQICELLLRKGANINEKTKEF 400
Q E LLR GA+IN ++ +F
Sbjct: 747 HAQTVETLLRHGAHINLQSLKF 768
Score = 72.8 bits (177), Expect = 2e-12
Identities = 53/164 (32%), Positives = 73/164 (44%), Gaps = 10/164 (6%)
Query: 629 LDLVKDGDT----------DIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGR 678
+D + GDT D+ L A+LL A + K +N N + R
Sbjct: 411 VDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRR 470
Query: 679 HSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACV 738
STPLH+A V E LL VNA+D+ LH AA G LL++ NA V
Sbjct: 471 GSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASV 530
Query: 739 NATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPL 782
N D TP+H A Q G+ + +LL G D +L+ ++ PL
Sbjct: 531 NEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPL 574
>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
Length = 1050
Score = 130 bits (327), Expect = 7e-30
Identities = 124/454 (27%), Positives = 187/454 (41%), Gaps = 62/454 (13%)
Query: 191 EKMMA--LLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPL 248
EK+++ L P V + D R TPLH+AA + ++ LL+ GA V+A D PL
Sbjct: 441 EKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPL 500
Query: 249 HNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNC 308
H AC G+ VT LL+ + A D TPLH A + + L+ Y + L+
Sbjct: 501 HLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDI 560
Query: 309 HNKSAIDLAPTP-QLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETA 367
N+ TP + R Y+ +LLQ ++ K ET
Sbjct: 561 GNEKG----DTPLHIAARWGYQGVIETLLQNGASTEIQNRLK---------------ETP 601
Query: 368 LHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLH--------VASEKAHNDVVEVV 419
L CA S +I ++ + + K P+ ++ E + + +
Sbjct: 602 LKCALNS------KILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMS 655
Query: 420 VKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQ 479
+ D L RA G L+ R LL + E +
Sbjct: 656 ASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEW------------------TEEDLE 697
Query: 480 LLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQS----VNCRDIEGRQSTPLHFAAG 535
++ +S + E L + K + K+L V + VN +G S+PLH AA
Sbjct: 698 DAEDTVSAADPEFCHPLCQCPKCAPAQ--KRLAKVPASGLGVNVTSQDG--SSPLHVAAL 753
Query: 536 YNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTP 595
+ R ++ LL+HGA+ A++ VPLH AC GH++V + L+ A N DL TP
Sbjct: 754 HGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTP 813
Query: 596 LHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPL 629
L A + G +E+ LLLQHGA N GNT L
Sbjct: 814 LIYACSGGHHELVALLLQHGASINASNNKGNTAL 847
Score = 107 bits (267), Expect = 7e-23
Identities = 112/415 (26%), Positives = 162/415 (39%), Gaps = 66/415 (15%)
Query: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
TPLHVA+ +++++V A VNA D G T LH A G+ LLL Y +
Sbjct: 465 TPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEV 524
Query: 462 ISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRD 521
G T L + A G + VK L +CR
Sbjct: 525 QDNNGNTPLHL--------------------------ACTYGHEDCVKALVYYDVESCRL 558
Query: 522 IEGRQS--TPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELL- 578
G + TPLH AA + V+E LLQ+GA +++ PL A + V E
Sbjct: 559 DIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYH 618
Query: 579 ------VKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKN-RDGNTPLDL 631
K + + + ++ + + + TKK+ R+ L
Sbjct: 619 LSFERRQKSSEAPVQSPQRSVDSISQESSTSSFS--SMSASSRQEETKKDYREVEKLLRA 676
Query: 632 VKDGDTDI---------QDLLRGDAALLDAAKKGC---------------LARVKKLSSP 667
V DGD ++ +DL + + A + C LA+V
Sbjct: 677 VADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLG 736
Query: 668 DNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDV 727
NV +D S+PLH+AA + ++ LL+HGA+ A++ +PLH A GH V
Sbjct: 737 VNVTSQDG----SSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQV 792
Query: 728 AALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPL 782
L+ NA N D TPL A G +L ALLL HGA N +G T L
Sbjct: 793 VKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTAL 847
Score = 99.4 bits (246), Expect = 2e-20
Identities = 121/464 (26%), Positives = 183/464 (39%), Gaps = 45/464 (9%)
Query: 358 FKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVE 417
F T LH AA + + +LL+ KGA +N TPLH+A +K + V
Sbjct: 457 FSRDDRGHTPLHVAAVCG---QASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTL 513
Query: 418 VVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSY---GCDPNIISLQGFTALQM-- 472
+++ ++A DN G T LH A GH + L+ Y C +I + +G T L +
Sbjct: 514 LLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAA 573
Query: 473 --GNENV-QQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQST- 528
G + V + LLQ G S +E +L E + + K+ +V E RQ +
Sbjct: 574 RWGYQGVIETLLQNGAS---TEIQNRLKETPLKCALNS--KILSVMEAYHLSFERRQKSS 628
Query: 529 ------PLHFAAGYNRVSVVEYLLQHGADVHA----KDKGGLVPLHNACSYGHYEVAELL 578
P ++ S A KD + L A + G E+ L
Sbjct: 629 EAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYL 688
Query: 579 VKHGAVVNVADLWKFTPLHEA---AAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDG 635
++ W L +A + E C L Q + R P +
Sbjct: 689 LE----------WTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVN 738
Query: 636 DTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVA 695
T QD G + L AA G A + L N + PLHLA + +V
Sbjct: 739 VTS-QD---GSSPLHVAALHG-RADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVV 793
Query: 696 EYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQK 755
+ LL A N +D G PL A S GH ++ ALL+++ A +NA++ T LHEA +
Sbjct: 794 KCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIE 853
Query: 756 GRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMP 799
+ LLL HGA + N+ +T +D + L +P
Sbjct: 854 KHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVP 897
Score = 98.6 bits (244), Expect = 3e-20
Identities = 131/551 (23%), Positives = 198/551 (35%), Gaps = 118/551 (21%)
Query: 42 RLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSF 101
RL P V R TPLH AA G+ +++ L+ GA V A D G PLH AC
Sbjct: 447 RLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQK 506
Query: 102 GHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTAL 161
G+ V LLL + A +DN TPLH A G D L+ + E L
Sbjct: 507 GYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVE--------SCRL 558
Query: 162 DLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGY 221
D+ G K D TPL H+AA +
Sbjct: 559 DI----------GNEKGD------------------TPL---------------HIAARW 575
Query: 222 NRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPL 281
+++ LLQ+GA +++ PL A + ++ M+ + +
Sbjct: 576 GYQGVIETLLQNGASTEIQNRLKETPLKCAL-------------NSKILSVMEAYHLS-F 621
Query: 282 HEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAARE 341
+ V S S D S ++ + + +E + LL+A +
Sbjct: 622 ERRQKSSEAPVQSPQRS--VDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVAD 679
Query: 342 ADVTRIKKHL---------SLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGAN 392
D+ ++ L + + V+ P+ C +P KR + G
Sbjct: 680 GDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKR---LAKVPASGLG 736
Query: 393 INEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLL 452
+N +++ +PLHVA+ D++ +++KH A A + LH A GH Q + L
Sbjct: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796
Query: 453 LSYGCDPNIISLQGFTALQMG-----NENVQQLLQEGISLGNSEADRQLLEAAKAGDVET 507
L PN L G T L +E V LLQ G S+ S
Sbjct: 797 LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINAS----------------- 839
Query: 508 VKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNAC 567
+ +T LH A V VVE LL HGA V +K + C
Sbjct: 840 ---------------NNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVD--C 882
Query: 568 SYGHYEVAELL 578
+ + ++ ELL
Sbjct: 883 AEQNSKIMELL 893
Score = 93.2 bits (230), Expect = 1e-18
Identities = 91/353 (25%), Positives = 150/353 (42%), Gaps = 71/353 (20%)
Query: 31 ACRNGDVERVKRLVTPEKVNSRDTAGRKS--TPLHFAAGFGRKDVVEYLLQNGANVQARD 88
AC G + VK LV + + R G + TPLH AA +G + V+E LLQNGA+ + ++
Sbjct: 536 ACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQN 595
Query: 89 DGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLH-----------EAAIKG-- 135
PL A + +++++++ + R + P+ E++
Sbjct: 596 RLKETPLKCALN---SKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFS 652
Query: 136 ----------------KIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKD 179
+++ + + G +R T DL D
Sbjct: 653 SMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCH 712
Query: 180 ELLESARSGNEEKMMALL--TPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADV 237
L + + +K +A + + L VN + DG S+PLH+AA + R ++ LLL+HGA+
Sbjct: 713 PLCQCPKCAPAQKRLAKVPASGLGVNVTSQDG--SSPLHVAALHGRADLIPLLLKHGANA 770
Query: 238 HAKDKGDLVPLHNACSYGHYEVTE---------------------------------LLV 264
A++ VPLH AC GH++V + LL+
Sbjct: 771 GARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLL 830
Query: 265 KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLA 317
+HGA +NA + T LHEA + V V LLL +GA +LN ++A+D A
Sbjct: 831 QHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCA 883
Score = 84.3 bits (207), Expect = 6e-16
Identities = 83/321 (25%), Positives = 123/321 (38%), Gaps = 37/321 (11%)
Query: 517 VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAE 576
VN D G +TPLH A SV LL + A +D G PLH AC+YGH + +
Sbjct: 489 VNATDYHG--ATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVK 546
Query: 577 LLVKHGAV---VNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV- 632
LV + +++ + TPLH AA G + + LLQ+GA +NR TPL
Sbjct: 547 ALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCAL 606
Query: 633 -------------------KDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCR 673
K + +Q R ++ + + + S +
Sbjct: 607 NSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETK-- 664
Query: 674 DTQGRHSTPLHLAAGYNNLEVAEYLLQHGAD--------VNAQDKGGLIPLHNAASYGHV 725
R L A +LE+ YLL+ + V+A D PL
Sbjct: 665 -KDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPA 723
Query: 726 DVAALLIKYNAC-VNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDL 784
+ + VN T + +PLH AA GR L LLL HGA+ +N + PL L
Sbjct: 724 QKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHL 783
Query: 785 VSADDVSALLTAAMPPSALPS 805
++ + +A P+
Sbjct: 784 ACQQGHFQVVKCLLDSNAKPN 804
Score = 81.6 bits (200), Expect = 4e-15
Identities = 61/194 (31%), Positives = 92/194 (47%), Gaps = 25/194 (12%)
Query: 81 GANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVC 140
G NV ++D G PLH A G A+++ LLL+HGA+ AR+ PLH A +G V
Sbjct: 736 GVNVTSQD--GSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVV 793
Query: 141 IVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPL 200
LL A+P ++ G T L A SG +++ALL
Sbjct: 794 KCLLDSNAKPNKKDLSGNTPLIY---------------------ACSGGHHELVALLLQH 832
Query: 201 NVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVT 260
+ +AS+ + +T LH A V +V+LLL HGA V +K + C+ + ++
Sbjct: 833 GASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVD--CAEQNSKIM 890
Query: 261 ELLVKHGACVNAMD 274
ELL +CV ++D
Sbjct: 891 ELLQVVPSCVASLD 904
Score = 76.6 bits (187), Expect = 1e-13
Identities = 81/265 (30%), Positives = 110/265 (41%), Gaps = 38/265 (14%)
Query: 454 SYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCT 513
S G + Q + L + L + I+ GN + +LL + + D +TV+K+C
Sbjct: 374 SEGFGDRLFLKQRMSLLSQMTSSPTDCLFKHIASGNQKEVERLL-SQEDHDKDTVQKMCH 432
Query: 514 VQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYE 573
C D E S L N SVV ++D G PLH A G
Sbjct: 433 PLCF-CDDCEKLVSGRL------NDPSVVTPF--------SRDDRGHTPLHVAAVCGQAS 477
Query: 574 VAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVK 633
+ +LLV GA+VN D TPLH A KG + LLL + A ++ +GNTPL L
Sbjct: 478 LIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHL-- 535
Query: 634 DGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQG--RHSTPLHLAAGYNN 691
A G VK L D +CR G + TPLH+AA +
Sbjct: 536 ------------------ACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGY 577
Query: 692 LEVAEYLLQHGADVNAQDKGGLIPL 716
V E LLQ+GA Q++ PL
Sbjct: 578 QGVIETLLQNGASTEIQNRLKETPL 602
Score = 73.9 bits (180), Expect = 8e-13
Identities = 71/251 (28%), Positives = 111/251 (44%), Gaps = 45/251 (17%)
Query: 618 PTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDA-AKKGCLARVKKLSSPDNVNCRDTQ 676
P ++ G+TPL + + G A+L+D KG + VN D
Sbjct: 456 PFSRDDRGHTPLHVAA---------VCGQASLIDLLVSKGAM-----------VNATDYH 495
Query: 677 GRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYN- 735
G +TPLHLA V LL + A QD G PLH A +YGH D L+ Y+
Sbjct: 496 G--ATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDV 553
Query: 736 -AC-VNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSAL 793
+C ++ ++ TPLH AA+ G + LL +GA ++N+ +TPL + ++
Sbjct: 554 ESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSV 613
Query: 794 LTA-------AMPPSALPSCYKPQVLNGVRSPGATADALS--SGPSSPSSLSAASSLDNL 844
+ A S P V+SP + D++S S SS SS+SA+S +
Sbjct: 614 MEAYHLSFERRQKSSEAP----------VQSPQRSVDSISQESSTSSFSSMSASSRQEET 663
Query: 845 SGSFSELSSVV 855
+ E+ ++
Sbjct: 664 KKDYREVEKLL 674
Score = 73.2 bits (178), Expect = 1e-12
Identities = 106/445 (23%), Positives = 178/445 (40%), Gaps = 66/445 (14%)
Query: 25 ARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQ---NG 81
A L AC+ G + V L+ K ++ +TPLH A +G +D V+ L+
Sbjct: 497 ATPLHLACQKG-YQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVES 555
Query: 82 ANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKI---- 137
+ ++ G PLH A +G+ V+ LL++GA ++ TPL + A+ KI
Sbjct: 556 CRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPL-KCALNSKILSVM 614
Query: 138 ---DVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTG--------EYKKD-----EL 181
+ Q +E +++ R+ ++ S+ + + E KKD +L
Sbjct: 615 EAYHLSFERRQKSSEAPVQSPQ-RSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKL 673
Query: 182 LESARSGNEEKMMAL-------LTPLNVNCHASDGRKSTPL----HLAAGYNRVKIVQLL 230
L + G+ E + L L A+D PL A R+ V
Sbjct: 674 LRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVP-- 731
Query: 231 LQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRV 290
G V+ + PLH A +G ++ LL+KHGA A + Q PLH A +
Sbjct: 732 -ASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHF 790
Query: 291 EVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKH 350
+V LL A P + + + A + E +A LLQ + + K +
Sbjct: 791 QVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVAL------LLQHGASINASNNKGN 844
Query: 351 LSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEK 410
TALH A K + ELLL GA++ K T + A +
Sbjct: 845 ---------------TALHEAVIE---KHVFVVELLLLHGASVQVLNKRQRTAVDCAEQ- 885
Query: 411 AHNDVVEVVVKHEAKVNALDNLGQT 435
++ ++E++ + V +LD++ +T
Sbjct: 886 -NSKIMELLQVVPSCVASLDDVAET 909
Score = 57.4 bits (137), Expect = 8e-08
Identities = 44/125 (35%), Positives = 62/125 (49%), Gaps = 4/125 (3%)
Query: 14 ASAAAEAVEPAARELFEACRNGDVERVKRLVTPE-KVNSRDTAGRKSTPLHFAAGFGRKD 72
A+A A + A L AC+ G + VK L+ K N +D +G +TPL +A G +
Sbjct: 768 ANAGARNADQAV-PLHLACQQGHFQVVKCLLDSNAKPNKKDLSG--NTPLIYACSGGHHE 824
Query: 73 VVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAA 132
+V LLQ+GA++ A ++ G LH A H VV LLL HGA + T + A
Sbjct: 825 LVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAE 884
Query: 133 IKGKI 137
KI
Sbjct: 885 QNSKI 889
>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
Length = 1119
Score = 129 bits (323), Expect = 2e-29
Identities = 135/528 (25%), Positives = 234/528 (44%), Gaps = 57/528 (10%)
Query: 62 LHFAAGFGRKDVVEYLLQNGAN--VQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNA 119
LH+AA G+ +++E + ++ + + DD G PLH A E V LL GA+PN
Sbjct: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
Query: 120 RDNWNYTPLHEAAIKGKIDVCIVLLQHGA-EPTIRNTDGRTALDLA-------------D 165
R+ PLH A +V VLL+H + + +G TA+ +A
Sbjct: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
Query: 166 PSAKAVLTGEYKKDELLESARSGNEEKMMALLT-------PLNVNCHASDGRKSTPLHLA 218
AK + ++ + ++A SG++E M +L ++ + + K+TPLHLA
Sbjct: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
Query: 219 AGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGA----CVNAMD 274
++++++ L +GA + +KG +H A + G E+ +L++ + VN D
Sbjct: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
Query: 275 LWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHS 334
T LH A+ + E+ L+S GAD ++ +S + LA T + +
Sbjct: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILA-TASASWNIV-----NL 360
Query: 335 LLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANIN 394
LL + D IK + NF H + + + +QI EL++
Sbjct: 361 LLSKGAQVD---IKDNFGR---NFLHLTVQQPYGLKNLRPEFMQMQQIKELVM------- 407
Query: 395 EKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLS 454
++ + TPLH A + V ++ +++ ++ LH AA G + TC+ LL
Sbjct: 408 DEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQ 467
Query: 455 YGCDPNIIS---LQGFTALQMGNEN-----VQQLLQEG-ISLGNSEADRQLLEAAKAGDV 505
D +++ L G T L + +N VQ LL++G + L + L A+ G
Sbjct: 468 DISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYT 527
Query: 506 ETVKKLCTVQSVNCRD-IEGRQSTPLHFAAGYNRVSVVEYLLQHGADV 552
+T+K + ++ C D ++ +T LHFAA V LL H AD+
Sbjct: 528 QTMKVILDT-NLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI 574
Score = 129 bits (323), Expect = 2e-29
Identities = 130/505 (25%), Positives = 209/505 (41%), Gaps = 78/505 (15%)
Query: 346 RIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLH 405
+I + SLE+++ + T LHCA + + + LL +GAN N + + PLH
Sbjct: 81 KITRDSSLEVLH-EMDDYGNTPLHCAVEK---NQIESVKFLLSRGANPNLRNFNMMAPLH 136
Query: 406 VASEKAHNDVVEVVVKHEA-KVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISL 464
+A + +N+V++V+++H VN G T++ A + + ++LL G P +
Sbjct: 137 IAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNK 196
Query: 465 QGF-----TALQMGNENVQQLLQEG----------ISLGNSEADRQLLEAAKAGDVETVK 509
G A E ++ +L+ G I+ N+ L A + GD+E +K
Sbjct: 197 WGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIK 256
Query: 510 KLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGAD----VHAKDKGGLVPLHN 565
+C +E + T +HFAA +V+ ++ + V+ D LH
Sbjct: 257 -MCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHR 315
Query: 566 ACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDG 625
A + H+E+A+ L+ GA +N D +PL A A + I LLL GA K+ G
Sbjct: 316 ASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFG 375
Query: 626 NTPLDL-------VKDGDTDIQDLLRGDAALLDAAKKGC--LARVKKLSSPDNVN----- 671
L L +K+ + + + ++D GC L + P +VN
Sbjct: 376 RNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGF 435
Query: 672 ---CRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGAD---VNAQDKGGLIPLHNAASYGHV 725
+PLH AA Y + + LLQ +D +N D G+ PLH AA GH
Sbjct: 436 NVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHD 495
Query: 726 DVAALLIKYNA---------------------------------CVNATDKWAFTPLHEA 752
V LL+K A C + D+ T LH A
Sbjct: 496 KVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFA 555
Query: 753 AQKGRTQLCALLLAHGADPTLKNQE 777
A++G + ALLL+H AD L Q+
Sbjct: 556 AREGHAKAVALLLSHNADIVLNKQQ 580
Score = 119 bits (299), Expect = 1e-26
Identities = 141/537 (26%), Positives = 215/537 (40%), Gaps = 61/537 (11%)
Query: 205 HASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLV 264
H D +TPLH A N+++ V+ LL GA+ + ++ + PLH A + EV ++L+
Sbjct: 92 HEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLL 151
Query: 265 KHGAC-VNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLK 323
+H VN T + A + N E +LL GA P N I A K
Sbjct: 152 EHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSK 211
Query: 324 ERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQIC 383
E + +L+ E +R L + +N T LH A + + ++C
Sbjct: 212 ECM------EIILRFGEEHGYSR---QLHINFMN----NGKATPLHLAVQNGDLEMIKMC 258
Query: 384 ELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAK----VNALDNLGQTSLHR 439
L GA I+ K T +H A+ + ++V++++ + VN D +T LHR
Sbjct: 259 ---LDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHR 315
Query: 440 AAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN-----VQQLLQEGISLG-NSEAD 493
A+ H + L+S G D N I +G + L + + V LL +G +
Sbjct: 316 ASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFG 375
Query: 494 RQLLEAA---KAGDVETVKKLCTVQSVN--CRDIEGRQSTPLHFAAGYNRVSVVEYLLQH 548
R L G + +Q + D + TPLH+A V LL
Sbjct: 376 RNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGF 435
Query: 549 GADVHAKDKGGLVPLHNACSYGHYEVAELL---VKHGAVVNVADLWKFTPLHEAAAKGKY 605
+H+K K PLH A SYG + L + ++N DL TPLH AA G
Sbjct: 436 NVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHD 495
Query: 606 EICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLS 665
++ +LLL+ GA + +G T L A G + K+
Sbjct: 496 KVVQLLLKKGA-LFLSDHNGWT---------------------ALHHASMGGYTQTMKVI 533
Query: 666 SPDNVNCRDTQGRH-STPLHLAAGYNNLEVAEYLLQHGADV--NAQDKGGL-IPLHN 718
N+ C D +T LH AA + + LL H AD+ N Q L + LHN
Sbjct: 534 LDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHN 590
Score = 102 bits (254), Expect = 2e-21
Identities = 101/358 (28%), Positives = 150/358 (41%), Gaps = 61/358 (17%)
Query: 25 ARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGAN- 83
A L A +NGD+E +K + GR T +HFAA G ++V+ ++ + +
Sbjct: 240 ATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGR-CTAIHFAATQGATEIVKLMISSYSGS 298
Query: 84 ---VQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVC 140
V D LH A F H E+ + L+ GAD N D+ +PL A ++
Sbjct: 299 VDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIV 358
Query: 141 IVLLQHGAEPTIRNTDGRTALDLA--DPSAKAVLTGEYKKDELLE--------------- 183
+LL GA+ I++ GR L L P L E+ + + ++
Sbjct: 359 NLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLH 418
Query: 184 -SARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDK 242
+ R G + LL NV+ H+ K +PLH AA Y R+ Q LLQ +D ++
Sbjct: 419 YACRQGGPGSVNNLLG-FNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNE 477
Query: 243 GDL---VPLHNACSYGHYEVTELLVKHGA------------------------------- 268
GDL PLH A GH +V +LL+K GA
Sbjct: 478 GDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTN 537
Query: 269 --CVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKE 324
C + +D T LH AA + + +LLLS+ AD +LN S + LA + KE
Sbjct: 538 LKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNAD-IVLNKQQASFLHLALHNKRKE 594
Score = 91.3 bits (225), Expect = 5e-18
Identities = 76/286 (26%), Positives = 127/286 (44%), Gaps = 29/286 (10%)
Query: 530 LHFAAGYNRVSVVEYLLQHGA--DVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV 587
LH+AA ++ ++E + + + +H D G PLH A E + L+ GA N+
Sbjct: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
Query: 588 ADLWKFTPLHEAAAKGKYEICKLLLQHGA-DPTKKNRDGNTPLDL--VKDGDTDIQDLLR 644
+ PLH A E+ K+LL+H D + +GNT + + + +Q LL+
Sbjct: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
Query: 645 GDAALLDAAKKGCLARVKKLSSPDNVNCRD-------------------TQGRHSTPLHL 685
A + K GC + + + + C + +TPLHL
Sbjct: 187 KGAKPCKSNKWGCFP-IHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHL 245
Query: 686 AAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNA----CVNAT 741
A +LE+ + L +GA ++ +KG +H AA+ G ++ L+I + VN T
Sbjct: 246 AVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTT 305
Query: 742 DKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSA 787
D T LH A+ +L L++ GAD + EG++PL L +A
Sbjct: 306 DGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATA 351
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 127 bits (320), Expect = 5e-29
Identities = 109/301 (36%), Positives = 136/301 (45%), Gaps = 14/301 (4%)
Query: 28 LFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQA 86
L +A G V +L+ V RD AGR TPLH A G +V LLQ GA V A
Sbjct: 45 LLQAVWRGPAGLVTQLLRQGASVEERDHAGR--TPLHLAVLRGHAPLVRLLLQRGAPVGA 102
Query: 87 RDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 146
D G LH A GH+ V LLL+ GA AR TPLH AA G + LL+
Sbjct: 103 VDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEA 162
Query: 147 -GAEPTIRNTD---GRTALDLADPSAK-AVLT-----GEYKKDELLESARSGNEEKMMAL 196
G P + G TA A + AVL G LL +A +G + L
Sbjct: 163 PGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFL 222
Query: 197 LTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGH 256
L A DG +T L LAA R + +++LL HGAD +D+ LH A + GH
Sbjct: 223 LAR-GARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGH 281
Query: 257 YEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDL 316
+LLV GA V+A D TPLH A+ + VEV LL GA K+ + L
Sbjct: 282 LLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHL 341
Query: 317 A 317
A
Sbjct: 342 A 342
Score = 125 bits (315), Expect = 2e-28
Identities = 112/326 (34%), Positives = 143/326 (43%), Gaps = 49/326 (15%)
Query: 496 LLEAAKAGDVETVKKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA 554
LL+A G V +L SV RD GR TPLH A +V LLQ GA V A
Sbjct: 45 LLQAVWRGPAGLVTQLLRQGASVEERDHAGR--TPLHLAVLRGHAPLVRLLLQRGAPVGA 102
Query: 555 KDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQH 614
D+ G LH A +GH VAELL++ GA TPLH AAA G + LL+
Sbjct: 103 VDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEA 162
Query: 615 -----GADPTKKNRDGNTPLDLVKDGDTDIQDLLRG-----DAALLDAAKKG-------C 657
A + R G + +LL D ALL AA G
Sbjct: 163 PGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFL 222
Query: 658 LARVKKLSSPDNVNC---------------------------RDTQGRHSTPLHLAAGYN 690
LAR ++ + D RD GR + LH AA
Sbjct: 223 LARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSA--LHRAAARG 280
Query: 691 NLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLH 750
+L + L+ GA+V+A+D GL PLH+A+ GHV+VA L+ A V+AT TPLH
Sbjct: 281 HLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLH 340
Query: 751 EAAQKGRTQLCALLLAHGADPTLKNQ 776
AA++G LLL+ GA PTL+ Q
Sbjct: 341 LAAERGHGPTVGLLLSRGASPTLRTQ 366
Score = 125 bits (315), Expect = 2e-28
Identities = 114/361 (31%), Positives = 162/361 (44%), Gaps = 53/361 (14%)
Query: 386 LLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGH 445
LLR+GA++ E+ TPLH+A + H +V ++++ A V A+D G+T+LH AA+ GH
Sbjct: 60 LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
Query: 446 LQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDV 505
+ LLL G S G T L +LG++ +LLEA G
Sbjct: 120 SRVAELLLQRGASAAARSGTGLTPLHWA-----------AALGHTLLAARLLEAPGPGPA 168
Query: 506 ETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHN 565
+ + R T H+AA R++V+E L GA + G L+
Sbjct: 169 AAEAE------------DARGWTAAHWAAAGGRLAVLELLAAGGAGLD----GALLV--- 209
Query: 566 ACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDG 625
A + G L+ GA V+ D T L AAA G+ + ++LL HGADP ++R G
Sbjct: 210 AAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHG 269
Query: 626 NTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPD-NVNCRDTQGRHSTPLH 684
+ AL AA +G L V+ L + V+ RDT G TPLH
Sbjct: 270 RS--------------------ALHRAAARGHLLAVQLLVTQGAEVDARDTLGL--TPLH 307
Query: 685 LAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKW 744
A+ ++EVA LL GA V+A PLH AA GH LL+ A +W
Sbjct: 308 HASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQW 367
Query: 745 A 745
A
Sbjct: 368 A 368
Score = 95.9 bits (237), Expect = 2e-19
Identities = 117/395 (29%), Positives = 170/395 (43%), Gaps = 45/395 (11%)
Query: 117 PNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEY 176
P+ W + L +A +G + LL+ GA R+ GRT L LA VL G
Sbjct: 36 PSVVQGWGH--LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLA------VLRGH- 86
Query: 177 KKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGAD 236
++ LL A D T LH AA + ++ +LLLQ GA
Sbjct: 87 --------------APLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGAS 132
Query: 237 VHAKDKGDLVPLHNACSYGHYEVTELLVKHG----ACVNAMDLWQFTPLHEAASKNRVEV 292
A+ L PLH A + GH + L++ A A D +T H AA+ R+ V
Sbjct: 133 AAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAV 192
Query: 293 CSLLLSYGA--DPTLL---NCHNKSAID--LAPTPQLKERLAYEFKGHSLLQA-AREADV 344
LL + GA D LL +A+ LA ++ R L A R D+
Sbjct: 193 LELLAAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDI 252
Query: 345 TRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPL 404
+ H + + +H ++ ALH AAA + Q LL+ +GA ++ + LTPL
Sbjct: 253 EVLLGHGADPGIRDRHGRS---ALHRAAARGHLLAVQ---LLVTQGAEVDARDTLGLTPL 306
Query: 405 HVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISL 464
H AS + H +V ++ A+V+A L +T LH AA GH T LLLS G P +
Sbjct: 307 HHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPT-LRT 365
Query: 465 QGFTALQMGNENVQQLLQEGISLGNSEADRQLLEA 499
Q QM ++ Q L E LG E + + +E+
Sbjct: 366 QWAEVAQMPEGDLPQALPE---LGGGEKECEGIES 397
Score = 73.2 bits (178), Expect = 1e-12
Identities = 57/137 (41%), Positives = 67/137 (48%), Gaps = 8/137 (5%)
Query: 52 RDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLL 111
RD GR + LH AA G V+ L+ GA V ARD GL PLH+A GH EV LL
Sbjct: 265 RDRHGRSA--LHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLL 322
Query: 112 RHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTAL----DLADPS 167
GA +A TPLH AA +G +LL GA PT+R A DL P
Sbjct: 323 DRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGDL--PQ 380
Query: 168 AKAVLTGEYKKDELLES 184
A L G K+ E +ES
Sbjct: 381 ALPELGGGEKECEGIES 397
Score = 64.3 bits (155), Expect = 6e-10
Identities = 36/90 (40%), Positives = 48/90 (53%)
Query: 698 LLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGR 757
LL+ GA V +D G PLH A GH + LL++ A V A D+ T LHEAA G
Sbjct: 60 LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
Query: 758 TQLCALLLAHGADPTLKNQEGQTPLDLVSA 787
+++ LLL GA ++ G TPL +A
Sbjct: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAA 149
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,524,887
Number of Sequences: 37866
Number of extensions: 2068230
Number of successful extensions: 19053
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 383
Number of HSP's successfully gapped in prelim test: 98
Number of HSP's that attempted gapping in prelim test: 5818
Number of HSP's gapped (non-prelim): 4860
length of query: 1166
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1053
effective length of database: 13,968,660
effective search space: 14708998980
effective search space used: 14708998980
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.