Search of human proteins with 51468073

Search of human proteins with 51468073

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|51468073 solute carrier family 6, member 19 [Homo sapiens]
         (634 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|51468073 solute carrier family 6, member 19 [Homo sapiens]        1297   0.0  
gi|194018524 solute carrier family 6, member 18 [Homo sapiens]        695   0.0  
gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo s...   597   e-170
gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo s...   527   e-149
gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo s...   516   e-146
gi|58219014 solute carrier family 6, member 17 [Homo sapiens]         512   e-145
gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo ...   441   e-123
gi|92859670 solute carrier family 6 (neurotransmitter transporte...   401   e-111
gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo sap...   393   e-109
gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo sap...   393   e-109
gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo sap...   392   e-109
gi|188528618 solute carrier family 6 (neurotransmitter transport...   382   e-106
gi|134304856 solute carrier family 6, member 7 [Homo sapiens]         379   e-105
gi|171184408 solute carrier family 6 (neurotransmitter transport...   377   e-104
gi|171184406 solute carrier family 6 (neurotransmitter transport...   377   e-104
gi|171184404 solute carrier family 6 (neurotransmitter transport...   377   e-104
gi|197276623 solute carrier family 6 (neurotransmitter transport...   366   e-101
gi|54607094 solute carrier family 6 (neurotransmitter transporte...   366   e-101
gi|4507043 solute carrier family 6 member 4 [Homo sapiens]            366   e-101
gi|21361581 solute carrier family 6 (neurotransmitter transporte...   366   e-101
gi|7657587 solute carrier family 6 (neurotransmitter transporter...   362   e-100
gi|4507041 solute carrier family 6 (neurotransmitter transporter...   360   2e-99
gi|55749589 solute carrier family 6, member 16 [Homo sapiens]         360   3e-99
gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo sapi...   358   1e-98
gi|6005715 solute carrier family 6 (amino acid transporter), mem...   355   9e-98
gi|4557046 solute carrier family 6 member 2 [Homo sapiens]            354   1e-97
gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo sa...   278   1e-74
gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo sa...   267   3e-71
gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo s...   243   5e-64
gi|197276625 solute carrier family 6 (neurotransmitter transport...   136   5e-32

>gi|51468073 solute carrier family 6, member 19 [Homo sapiens]
          Length = 634

 Score = 1297 bits (3357), Expect = 0.0
 Identities = 634/634 (100%), Positives = 634/634 (100%)

Query: 1   MVRLVLPNPGLDARIPSLAELETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPY 60
           MVRLVLPNPGLDARIPSLAELETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPY
Sbjct: 1   MVRLVLPNPGLDARIPSLAELETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPY 60

Query: 61  LCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASML 120
           LCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASML
Sbjct: 61  LCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASML 120

Query: 121 TSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDCPLNENQTGYVDECARSSPVDYFWYRET 180
           TSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDCPLNENQTGYVDECARSSPVDYFWYRET
Sbjct: 121 TSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDCPLNENQTGYVDECARSSPVDYFWYRET 180

Query: 181 LNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIR 240
           LNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIR
Sbjct: 181 LNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIR 240

Query: 241 GLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCE 300
           GLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCE
Sbjct: 241 GLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCE 300

Query: 301 KDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENF 360
           KDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENF
Sbjct: 301 KDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENF 360

Query: 361 VDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLF 420
           VDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLF
Sbjct: 361 VDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLF 420

Query: 421 FIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQY 480
           FIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQY
Sbjct: 421 FIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQY 480

Query: 481 WLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPL 540
           WLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPL
Sbjct: 481 WLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPL 540

Query: 541 LMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGY 600
           LMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGY
Sbjct: 541 LMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGY 600

Query: 601 AIYKLIRNHCQKPGDHQGLVSTLSTASMNGDLKY 634
           AIYKLIRNHCQKPGDHQGLVSTLSTASMNGDLKY
Sbjct: 601 AIYKLIRNHCQKPGDHQGLVSTLSTASMNGDLKY 634


>gi|194018524 solute carrier family 6, member 18 [Homo sapiens]
          Length = 628

 Score =  695 bits (1794), Expect = 0.0
 Identities = 317/575 (55%), Positives = 429/575 (74%), Gaps = 1/575 (0%)

Query: 32  RPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFA 91
           RPKWDNKAQY+L+C GF VGLGN+WRFPYLCQ++GGGAF+IP++I LV EGIP+ ++E A
Sbjct: 18  RPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVELA 77

Query: 92  IGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWS 151
           IGQRLR+GS+GVW++I P L G+GL  +  SF++ LYYNTI++W++WYL NSFQ PLPWS
Sbjct: 78  IGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPWS 137

Query: 152 DCPLNENQTGYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYMC 211
            CP + N+TG+V+EC  SS V YFWYR+TLNI+  I+DSGSIQWW+L+CLA +W+V+YMC
Sbjct: 138 SCPPDLNRTGFVEECQGSSAVSYFWYRQTLNITADINDSGSIQWWLLICLAASWAVVYMC 197

Query: 212 TIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDA 271
            IRGIETTGK +Y T+  PY+VLTIFLIRGLTL GAT G+++LFTPN+  L  P  WLDA
Sbjct: 198 VIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNMHILQNPRVWLDA 257

Query: 272 GAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQ 331
             Q+FFS SLAFGG I+F+SYNS  N+C+KD+V+++++N  TS+Y +I V+SV+GF+AT 
Sbjct: 258 ATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASIAVFSVLGFKATN 317

Query: 332 RYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSE 391
            Y+ C   NIL+LIN FD PE +++++++  +    NA+ P   AQL  + C +  FL +
Sbjct: 318 DYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQLPLKACLLEDFLDK 377

Query: 392 AVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVIPP 451
           +  G GLAF+VFTE    MP +P+W++LFF MLF LGLS+MFG +E V+ PL D+ V+P 
Sbjct: 378 SASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTVEAVITPLLDVGVLPR 437

Query: 452 KWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGV 511
             PKE LTGL+CL  FL    FTL SG YWL + D++A S  LL++AF E+  VVYVYG+
Sbjct: 438 WVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASPNLLMLAFLEVVGVVYVYGM 497

Query: 512 DRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFP 571
            RF  DI +M G +P+ +W++TWRVVSPLL L IF+ + ++   + L Y  W+P YE FP
Sbjct: 498 KRFCDDIAWMTGRRPSPYWRLTWRVVSPLL-LTIFVAYIILLFWKPLRYKAWNPKYELFP 556

Query: 572 KSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKLI 606
             Q+  YP W     V+++ +P L +P  A+ +L+
Sbjct: 557 SRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLL 591


>gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo
           sapiens]
          Length = 592

 Score =  597 bits (1538), Expect = e-170
 Identities = 269/585 (45%), Positives = 395/585 (67%), Gaps = 6/585 (1%)

Query: 31  SRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEF 90
           +RP W N  Q++  C+ + VGLGNVWRFPYLCQ +GGG+F++P++I+L++EG+PLLYLE 
Sbjct: 4   ARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLEL 63

Query: 91  AIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPW 150
           A+GQR+R+GS+G W +I P L G+G+AS++ SF + +YYN I +W  WYLF+SFQ+PLPW
Sbjct: 64  AVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPW 123

Query: 151 SDCPLNENQTGYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYM 210
           S CPLN N TGY +EC ++S   YFWYR+TLNIS S+ ++G +QW   LCL  AW V+Y+
Sbjct: 124 SVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVYL 183

Query: 211 CTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLD 270
           C +RG E+TGK VY T++LPY VL I+LIRGLTL GATNG++++FTP + +LA P  W++
Sbjct: 184 CILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQLANPKAWIN 243

Query: 271 AGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRAT 330
           A  Q+FFS  L FG LI+F+SYN   NNC+K ++IVS+IN FTS++ +IV +S+ GF+AT
Sbjct: 244 AATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKAT 303

Query: 331 QRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLV--FQTCDINAF 388
             Y++C     L L N FDL +G +T  N   ++    ++ P+ Y+++    + C + + 
Sbjct: 304 FNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSLESE 363

Query: 389 LSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRV 448
           L  AV+GTGLAFIV+TEAI  M +S LWSVL+F ML  LG+ SM GN   ++ PL D ++
Sbjct: 364 LDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDSKI 423

Query: 449 IPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYV 508
           I    PKE ++GL+CL    IG +FT+ +G YW  + + YA ++ LL+I   E  +V YV
Sbjct: 424 ISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYV 483

Query: 509 YGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEV-SQELTYSIWDPGY 567
           YG+ RF  D++ M G   + +W+V W  VSPLL++ +F+F+    + +  L Y  WD   
Sbjct: 484 YGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWDASQ 543

Query: 568 EEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQK 612
            +        YP +   V+ ++    ++ IP  A+   ++   ++
Sbjct: 544 GQLVTK---DYPAYALAVIGLLVASSTMCIPLAALGTFVQRRLKR 585


>gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo
           sapiens]
          Length = 555

 Score =  527 bits (1357), Expect = e-149
 Identities = 246/585 (42%), Positives = 364/585 (62%), Gaps = 43/585 (7%)

Query: 31  SRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEF 90
           +RP W N  Q++  C+ + VGLGNVWRFPYLCQ +GGG+F++P++I+L++EG+PLLYLE 
Sbjct: 4   ARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLEL 63

Query: 91  AIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPW 150
           A+GQR+R+GS+G W +I P L G+G+AS++ SF + +YYN I +W  WYLF+SFQ+PLPW
Sbjct: 64  AVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPW 123

Query: 151 SDCPLNENQTGYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYM 210
           S CPLN N TGY +EC ++S   YFWYR+TLNIS S+ ++G +QW   LCL  AW V+Y+
Sbjct: 124 SVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVYL 183

Query: 211 CTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLD 270
           C +RG E+TGK                                     + +LA P  W++
Sbjct: 184 CILRGTESTGK-------------------------------------IEQLANPKAWIN 206

Query: 271 AGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRAT 330
           A  Q+FFS  L FG LI+F+SYN   NNC+K ++IVS+IN FTS++ +IV +S+ GF+AT
Sbjct: 207 AATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKAT 266

Query: 331 QRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVFQ--TCDINAF 388
             Y++C     L L N FDL +G +T  N   ++    ++ P+ Y+++  Q   C + + 
Sbjct: 267 FNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSLESE 326

Query: 389 LSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRV 448
           L  AV+GTGLAFIV+TEAI  M +S LWSVL+F ML  LG+ SM GN   ++ PL D ++
Sbjct: 327 LDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDSKI 386

Query: 449 IPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYV 508
           I    PKE ++GL+CL    IG +FT+ +G YW  + + YA ++ LL+I   E  +V YV
Sbjct: 387 ISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYV 446

Query: 509 YGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEV-SQELTYSIWDPGY 567
           YG+ RF  D++ M G   + +W+V W  VSPLL++ +F+F+    + +  L Y  WD   
Sbjct: 447 YGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWDASQ 506

Query: 568 EEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQK 612
            +        YP +   V+ ++    ++ IP  A+   ++   ++
Sbjct: 507 GQLVTK---DYPAYALAVIGLLVASSTMCIPLAALGTFVQRRLKR 548


>gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo
           sapiens]
          Length = 730

 Score =  516 bits (1329), Expect = e-146
 Identities = 262/593 (44%), Positives = 370/593 (62%), Gaps = 35/593 (5%)

Query: 27  EEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLL 86
           E    RP W++K QY+L  +GF VGLGNVWRFPYLCQ +GGGA+++P+LILL++ GIPL 
Sbjct: 56  EVEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLF 115

Query: 87  YLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQE 146
           +LE ++GQR+RRGS+GVW+ I P L G+G AS +  + V LYYN II W ++Y   SFQ+
Sbjct: 116 FLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQ 175

Query: 147 PLPWSDCPL--NENQTGYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACA 204
           PLPW  CPL  N + T    EC +SS   Y+WYRE LNIS+SIS+SG + W M +CL  A
Sbjct: 176 PLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAA 235

Query: 205 WSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQ 264
           W ++ +  I+GI+++GK +Y +S  PYVVL  FLIR   L G+ +GI  +FTP +  + +
Sbjct: 236 WVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLE 295

Query: 265 PDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSV 324
           P  W +A  QVFF+  L FGG+I+FSSYN   NNC  D+V+VS IN FTSV   +VV++V
Sbjct: 296 PKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAV 355

Query: 325 IGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENF-----------------VDMQQRC 367
           +GF+A    + C + N  T++    L  GN++Q+                    D+ Q+ 
Sbjct: 356 LGFKANVINEKCITQNSETIMK--FLKMGNISQDIIPHHINLSTVTAEDYHLVYDIIQKV 413

Query: 368 NASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCL 427
              +   +  L   +C I   L++AV+GTGLAFI FTEA+T  P SP WSV+FF+ML  L
Sbjct: 414 KEEE---FPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNL 470

Query: 428 GLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDS 487
           GL SMFG +EG+V P+ D      K  KE+LT + CL  F IG IF   SG Y++++ D 
Sbjct: 471 GLGSMFGTIEGIVTPIVDTF----KVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDD 526

Query: 488 YAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFL 547
           Y+ ++PLLI+   E  +V +VYG+D+F +D++ M+G  P+ ++   W+ +SPL++L + +
Sbjct: 527 YSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLI 586

Query: 548 FFFVVEVSQELTYSIW--DPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIP 598
              V        Y+ W  D   EEF     +SYP W  VV V +     L +P
Sbjct: 587 ASVVNMGLSPPGYNAWIEDKASEEF-----LSYPTWGLVVCVSLVVFAILPVP 634


>gi|58219014 solute carrier family 6, member 17 [Homo sapiens]
          Length = 727

 Score =  512 bits (1319), Expect = e-145
 Identities = 258/615 (41%), Positives = 376/615 (61%), Gaps = 31/615 (5%)

Query: 25  EQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIP 84
           E+ +A  RP W++K QY+L  +GF VGLGN+WRFPYLCQ +GGGA+++P+L+LL++ GIP
Sbjct: 53  EELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIP 112

Query: 85  LLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSF 144
           L +LE A+GQR+RRGS+GVW  I P L G+G +S +    VGLYYN II W ++Y F SF
Sbjct: 113 LFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSF 172

Query: 145 QEPLPWSDCPLNENQTGYV--DECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLA 202
           Q PLPWS+CP+  N +  V   EC +SS   YFWYRE L+IS SIS+SG + W M LCL 
Sbjct: 173 QYPLPWSECPVVRNGSVAVVEAECEKSSATTYFWYREALDISDSISESGGLNWKMTLCLL 232

Query: 203 CAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTEL 262
            AWS++ M  ++GI+++GK +Y +S  PYVVL  FL+RGL L+GA +GI+ +FTP + ++
Sbjct: 233 VAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKM 292

Query: 263 AQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVY 322
             P  W +A  QVFF+  L FGG+I+FSSYN   NNC  D+ +VS IN FTSV   +VV+
Sbjct: 293 LDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVF 352

Query: 323 SVIGFRATQRYDDCFSTN---ILTLINGFDLPE---------GNVTQENFVDMQQRCNAS 370
           +V+GF+A    + C   N   IL  +N   L            ++T +++++M       
Sbjct: 353 AVLGFKANIMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTV 412

Query: 371 DPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLS 430
               ++ L    C +   L ++V+GTGLAFI FTEA+T  P SP WSV+FF+ML  LGL 
Sbjct: 413 KEDQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLG 472

Query: 431 SMFGNMEGVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAG 490
           SM G M G+  P+ D      K PKE+ T   C+  FL+G +F   SG Y++++ D Y+ 
Sbjct: 473 SMIGTMAGITTPIIDTF----KVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSA 528

Query: 491 SIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFF 550
           ++PL +I   E  +V ++YG  +F +++  M+G +P  F+   W+ VSPL M        
Sbjct: 529 TLPLTLIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMA------- 581

Query: 551 VVEVSQELTYSIWDPGYEEFPKSQK----ISYPNWVYVVVVIVAGVPSLTIPGYAIYKLI 606
           V+  +  +   +  PGY  + K +     + +PNW   +++ +  V +L IP   ++ L 
Sbjct: 582 VLTTASIIQLGVTPPGYSAWIKEEAAERYLYFPNWAMALLITLIVVATLPIP--VVFVLR 639

Query: 607 RNHCQKPGDHQGLVS 621
             H    G +   VS
Sbjct: 640 HFHLLSDGSNTLSVS 654


>gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo
           sapiens]
          Length = 623

 Score =  441 bits (1134), Expect = e-123
 Identities = 229/538 (42%), Positives = 326/538 (60%), Gaps = 35/538 (6%)

Query: 82  GIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLF 141
           GIPL +LE ++GQR+RRGS+GVW+ I P L G+G AS +  + V LYYN II W ++Y  
Sbjct: 4   GIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFS 63

Query: 142 NSFQEPLPWSDCPL--NENQTGYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLL 199
            SFQ+PLPW  CPL  N + T    EC +SS   Y+WYRE LNIS+SIS+SG + W M +
Sbjct: 64  QSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTI 123

Query: 200 CLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNV 259
           CL  AW ++ +  I+GI+++GK +Y +S  PYVVL  FLIR   L G+ +GI  +FTP +
Sbjct: 124 CLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKL 183

Query: 260 TELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAI 319
             + +P  W +A  QVFF+  L FGG+I+FSSYN   NNC  D+V+VS IN FTSV   +
Sbjct: 184 EIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATL 243

Query: 320 VVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENF-----------------VD 362
           VV++V+GF+A    + C + N  T++    L  GN++Q+                    D
Sbjct: 244 VVFAVLGFKANVINEKCITQNSETIMK--FLKMGNISQDIIPHHINLSTVTAEDYHLVYD 301

Query: 363 MQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFI 422
           + Q+    +   +  L   +C I   L++AV+GTGLAFI FTEA+T  P SP WSV+FF+
Sbjct: 302 IIQKVKEEE---FPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFL 358

Query: 423 MLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWL 482
           ML  LGL SMFG +EG+V P+ D      K  KE+LT + CL  F IG IF   SG Y++
Sbjct: 359 MLVNLGLGSMFGTIEGIVTPIVDTF----KVRKEILTVICCLLAFCIGLIFVQRSGNYFV 414

Query: 483 SLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLM 542
           ++ D Y+ ++PLLI+   E  +V +VYG+D+F +D++ M+G  P+ ++   W+ +SPL++
Sbjct: 415 TMFDDYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLML 474

Query: 543 LIIFLFFFVVEVSQELTYSIW--DPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIP 598
           L + +   V        Y+ W  D   EEF     +SYP W  VV V +     L +P
Sbjct: 475 LSLLIASVVNMGLSPPGYNAWIEDKASEEF-----LSYPTWGLVVCVSLVVFAILPVP 527


>gi|92859670 solute carrier family 6 (neurotransmitter transporter,
           glycine), member 5 [Homo sapiens]
          Length = 797

 Score =  401 bits (1030), Expect = e-111
 Identities = 235/649 (36%), Positives = 336/649 (51%), Gaps = 117/649 (18%)

Query: 4   LVLPNPGLDARIP-SLAELETIEQE---EASSRPKWDNKAQYMLTCLGFCVGLGNVWRFP 59
           +VL   G+ + +P S+A + T E E   E  +R  W +K  ++L+ +G+ VGLGNVWRFP
Sbjct: 159 VVLATDGITSVLPGSVATVATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFP 218

Query: 60  YLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASM 119
           YL   +GGGAF+IP+L++L L G+P+ +LE ++GQ   +G + VW +I PAL+G G+A +
Sbjct: 219 YLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAI-PALQGCGIAML 277

Query: 120 LTSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDC--PLNE-------------------- 157
           + S ++ +YYN II + ++YLF SF   LPW  C  P N                     
Sbjct: 278 IISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHP 337

Query: 158 --------------------NQTGYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWM 197
                               N T   ++   S   +YF Y   L IS  I   G I+W +
Sbjct: 338 KIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSGSEEYFKYF-VLKISAGIEYPGEIRWPL 396

Query: 198 LLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTP 257
            LCL  AW ++Y    +GI+T+GK VY T+T PYVVL I LIRG+TL GA  GI +  TP
Sbjct: 397 ALCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITP 456

Query: 258 NVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYV 317
              +L     W DA  Q+FFS S A+GGLI+ SSYN  HNNC +D++IV+  N  TS++ 
Sbjct: 457 KWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFA 516

Query: 318 AIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQ 377
             V++SVIGF A +R                      V  EN  D               
Sbjct: 517 GFVIFSVIGFMANER---------------------KVNIENVAD--------------- 540

Query: 378 LVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNME 437
                           +G G+AF+V+ EA+T++PLSP W+++FF+ML  LGL +MF  +E
Sbjct: 541 ----------------QGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIE 584

Query: 438 GVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLII 497
            +V  + D      +  K V T   C+  F++GF      G Y   L+D+YA S  L+II
Sbjct: 585 TIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVII 644

Query: 498 AFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQE 557
           A  E+  + YVYG+ RF +DIE MIG +PNIFW+V W  V+P ++  I  F F       
Sbjct: 645 AIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQ----- 699

Query: 558 LTYSIWDP-GYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKL 605
                W+P  Y  +       YPNW  V+  ++     + IP   + K+
Sbjct: 700 -----WEPMTYGSY------RYPNWSMVLGWLMLACSVIWIPIMFVIKM 737


>gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo
           sapiens]
          Length = 633

 Score =  393 bits (1009), Expect = e-109
 Identities = 223/634 (35%), Positives = 338/634 (53%), Gaps = 107/634 (16%)

Query: 11  LDARIPSLAELETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAF 70
           L+  +PS    E  ++++   R  W N+ +++LT +G+ VGLGNVWRFPYLC  +GGGAF
Sbjct: 10  LNGAVPS----EATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAF 65

Query: 71  MIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYN 130
           M P+ I+L+  GIPL ++E + GQ   +G LGVW  I P  KG+G   M+ S  +G+YYN
Sbjct: 66  MFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYN 124

Query: 131 TIISWIMWYLFNSFQEPLPWSDC--PLNENQTGYVDECA--------------------- 167
            +I    +Y F+S    LPW+ C  P N +    V + +                     
Sbjct: 125 VVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNH 184

Query: 168 ---RSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVY 224
              R+SP + +W    L +S  I + G ++  +L CL  +W V+++C IRG++++GK VY
Sbjct: 185 SLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVY 244

Query: 225 ITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFG 284
            T+T PYVVLTI  +RG+TL+GA +GI++  TP   ++ +   W DA +Q+F+S   A+G
Sbjct: 245 FTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWG 304

Query: 285 GLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTL 344
           GLI+ +SYN  HNNC +DSVI+SI N  TSVY   V++S++G          F  N L  
Sbjct: 305 GLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILG----------FMANHL-- 352

Query: 345 INGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFT 404
             G D+                                         A  G GLAF+ + 
Sbjct: 353 --GVDVSR--------------------------------------VADHGPGLAFVAYP 372

Query: 405 EAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKW---PKEVLTGL 461
           EA+T +P+SPLWS+LFF ML  LGL + F  +E +V  + D   +  +W    K  +T  
Sbjct: 373 EALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVD--EVGNEWILQKKTYVTLG 430

Query: 462 ICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFM 521
           + +  FL+G   T  +G YWL L+D+YA S  L++I+     +++Y+YG   + +DI+ M
Sbjct: 431 VAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMM 490

Query: 522 IGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNW 581
           +G  P +F+Q+ WR VSP   +I F+  F V   Q +TY+ +              YP W
Sbjct: 491 LGFPPPLFFQICWRFVSP--AIIFFILVFTVIQYQPITYNHY-------------QYPGW 535

Query: 582 VYVVVVIVAGVPSLTIPGYAIYKLIRNHCQKPGD 615
              +  ++A    L IP YA+++L    C+  GD
Sbjct: 536 AVAIGFLMALSSVLCIPLYAMFRL----CRTDGD 565


>gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo
           sapiens]
          Length = 652

 Score =  393 bits (1009), Expect = e-109
 Identities = 223/637 (35%), Positives = 339/637 (53%), Gaps = 107/637 (16%)

Query: 8   NPGLDARIPSLAELETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGG 67
           +P  +  +PS    E  ++++   R  W N+ +++LT +G+ VGLGNVWRFPYLC  +GG
Sbjct: 26  SPEQNGAVPS----EATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGG 81

Query: 68  GAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGL 127
           GAFM P+ I+L+  GIPL ++E + GQ   +G LGVW  I P  KG+G   M+ S  +G+
Sbjct: 82  GAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGI 140

Query: 128 YYNTIISWIMWYLFNSFQEPLPWSDC--PLNENQTGYVDECA------------------ 167
           YYN +I    +Y F+S    LPW+ C  P N +    V + +                  
Sbjct: 141 YYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHL 200

Query: 168 ------RSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGK 221
                 R+SP + +W    L +S  I + G ++  +L CL  +W V+++C IRG++++GK
Sbjct: 201 LNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGK 260

Query: 222 AVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSL 281
            VY T+T PYVVLTI  +RG+TL+GA +GI++  TP   ++ +   W DA +Q+F+S   
Sbjct: 261 VVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGC 320

Query: 282 AFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNI 341
           A+GGLI+ +SYN  HNNC +DSVI+SI N  TSVY   V++S++G          F  N 
Sbjct: 321 AWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILG----------FMANH 370

Query: 342 LTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFI 401
           L    G D+                                         A  G GLAF+
Sbjct: 371 L----GVDVSR--------------------------------------VADHGPGLAFV 388

Query: 402 VFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKW---PKEVL 458
            + EA+T +P+SPLWS+LFF ML  LGL + F  +E +V  + D   +  +W    K  +
Sbjct: 389 AYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVD--EVGNEWILQKKTYV 446

Query: 459 TGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDI 518
           T  + +  FL+G   T  +G YWL L+D+YA S  L++I+     +++Y+YG   + +DI
Sbjct: 447 TLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDI 506

Query: 519 EFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISY 578
           + M+G  P +F+Q+ WR VSP   +I F+  F V   Q +TY+ +              Y
Sbjct: 507 QMMLGFPPPLFFQICWRFVSP--AIIFFILVFTVIQYQPITYNHY-------------QY 551

Query: 579 PNWVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQKPGD 615
           P W   +  ++A    L IP YA+++L    C+  GD
Sbjct: 552 PGWAVAIGFLMALSSVLCIPLYAMFRL----CRTDGD 584


>gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo
           sapiens]
          Length = 706

 Score =  392 bits (1006), Expect = e-109
 Identities = 220/623 (35%), Positives = 333/623 (53%), Gaps = 103/623 (16%)

Query: 22  ETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLE 81
           E  ++++   R  W N+ +++LT +G+ VGLGNVWRFPYLC  +GGGAFM P+ I+L+  
Sbjct: 90  EATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFC 149

Query: 82  GIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLF 141
           GIPL ++E + GQ   +G LGVW  I P  KG+G   M+ S  +G+YYN +I    +Y F
Sbjct: 150 GIPLFFMELSFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFF 208

Query: 142 NSFQEPLPWSDC--PLNENQTGYVDECA------------------------RSSPVDYF 175
           +S    LPW+ C  P N +    V + +                        R+SP + +
Sbjct: 209 SSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEY 268

Query: 176 WYRETLNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLT 235
           W    L +S  I + G ++  +L CL  +W V+++C IRG++++GK VY T+T PYVVLT
Sbjct: 269 WRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLT 328

Query: 236 IFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSV 295
           I  +RG+TL+GA +GI++  TP   ++ +   W DA +Q+F+S   A+GGLI+ +SYN  
Sbjct: 329 ILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKF 388

Query: 296 HNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNV 355
           HNNC +DSVI+SI N  TSVY   V++S++G          F  N L    G D+     
Sbjct: 389 HNNCYRDSVIISITNCATSVYAGFVIFSILG----------FMANHL----GVDVSR--- 431

Query: 356 TQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPL 415
                                               A  G GLAF+ + EA+T +P+SPL
Sbjct: 432 -----------------------------------VADHGPGLAFVAYPEALTLLPISPL 456

Query: 416 WSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKW---PKEVLTGLICLGTFLIGFI 472
           WS+LFF ML  LGL + F  +E +V  + D   +  +W    K  +T  + +  FL+G  
Sbjct: 457 WSLLFFFMLILLGLGTQFCLLETLVTAIVD--EVGNEWILQKKTYVTLGVAVAGFLLGIP 514

Query: 473 FTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQV 532
            T  +G YWL L+D+YA S  L++I+     +++Y+YG   + +DI+ M+G  P +F+Q+
Sbjct: 515 LTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQI 574

Query: 533 TWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGV 592
            WR VSP   +I F+  F V   Q +TY+ +              YP W   +  ++A  
Sbjct: 575 CWRFVSP--AIIFFILVFTVIQYQPITYNHY-------------QYPGWAVAIGFLMALS 619

Query: 593 PSLTIPGYAIYKLIRNHCQKPGD 615
             L IP YA+++L    C+  GD
Sbjct: 620 SVLCIPLYAMFRL----CRTDGD 638


>gi|188528618 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 1 [Homo sapiens]
          Length = 599

 Score =  382 bits (981), Expect = e-106
 Identities = 203/582 (34%), Positives = 310/582 (53%), Gaps = 75/582 (12%)

Query: 32  RPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFA 91
           R  W  +  ++++C+G+ +GLGNVWRFPYLC  +GGGAF+IP+ + L+  G+PL  LE +
Sbjct: 44  RDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECS 103

Query: 92  IGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWS 151
           +GQ    G LGVW  + P  KG+GLA+ + SF + +YY  IISW ++YL+NSF   LPW 
Sbjct: 104 LGQYTSIGGLGVWK-LAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWK 162

Query: 152 DC--PLNENQT----GYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAW 205
            C  P N ++       V+    +S V  FW R    ++  +   G I+W + + LA AW
Sbjct: 163 QCDNPWNTDRCFSNYSMVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAW 222

Query: 206 SVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQP 265
            ++Y C  +G+  TGK VY ++T PY++L I   RG+TL GA  GI+F  TPN  +L+  
Sbjct: 223 ILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDS 282

Query: 266 DTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVI 325
           + WLDA  Q+FFS+ L  G LI+  SYNS HNN  +DS+IV  IN  TS++   V++S++
Sbjct: 283 EVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIV 342

Query: 326 GFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVFQTCDI 385
           GF A                        +VT+ +  D+                      
Sbjct: 343 GFMA------------------------HVTKRSIADV---------------------- 356

Query: 386 NAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQD 445
                 A  G GLAF+ + EA+T++P+SPLW++LFF ML  LG+ S F  +EG +  L D
Sbjct: 357 ------AASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVD 410

Query: 446 LRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGS-IPLLIIAFCEMFS 504
                 +  +E+    +C+ ++LIG       G Y   L D Y+ S + LL + F E  S
Sbjct: 411 EYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVS 470

Query: 505 VVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWD 564
           + + YGV+RF  +I+ M+G +P I+W++ W   +P+++  +F+F  V      +   +  
Sbjct: 471 ISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYV-- 528

Query: 565 PGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKLI 606
                        +P W   V  ++A    + IPGY  Y  +
Sbjct: 529 -------------FPKWGQGVGWLMALSSMVLIPGYMAYMFL 557


>gi|134304856 solute carrier family 6, member 7 [Homo sapiens]
          Length = 636

 Score =  379 bits (974), Expect = e-105
 Identities = 202/602 (33%), Positives = 321/602 (53%), Gaps = 88/602 (14%)

Query: 24  IEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGI 83
           ++ + A+ R  W  K  ++L+C+G+CVGLGNVWRFPY   ++GGGAF++P+ ++L + GI
Sbjct: 29  LDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGI 88

Query: 84  PLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNS 143
           PL +LE ++GQ    G L VW  I P  KG G A +L   +V +YYN II+++++YLF S
Sbjct: 89  PLFFLELSLGQFSSLGPLAVWK-ISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFAS 147

Query: 144 FQEPLPWSDCP------------LNENQTGYV--DECARSSPVDYFWYRETLNI--STSI 187
               LPW  C             ++++  G +  +     SP + +W R  L+I  S  I
Sbjct: 148 LTSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEYWSRYVLHIQGSQGI 207

Query: 188 SDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGA 247
              G I+W + LCL  AW ++++C ++G++++GK VY T+T PY++L + L+RG+TL GA
Sbjct: 208 GSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGA 267

Query: 248 TNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVS 307
             GI F  TP    L     W++A  Q+F+S  + FGGL++F+SYN+ H N  +D+ IV+
Sbjct: 268 WKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVT 327

Query: 308 IINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRC 367
           + N  TS+     ++SV+G+                           ++QE  V + Q  
Sbjct: 328 LGNAITSILAGFAIFSVLGY---------------------------MSQELGVPVDQVA 360

Query: 368 NASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCL 427
            A                         G GLAF+V+ +A+T +PLSP WS LFF ML  L
Sbjct: 361 KA-------------------------GPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTL 395

Query: 428 GLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDS 487
           GL S F  +E +V  + D      +  K V +GLIC+  +L+G I T + G YWL LLD 
Sbjct: 396 GLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDD 455

Query: 488 YAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFL 547
           Y+ S  L+++      +V  VYG+ RF +DI  M+G KP ++++  W  +SP  +L + +
Sbjct: 456 YSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMV 515

Query: 548 FFFVVEVSQELTYSIWDPGYEEFPKSQKISY--PNWVYVVVVIVAGVPSLTIPGYAIYKL 605
           +  V                 ++  S+  SY  P W  ++ +++  +  L IP   +  +
Sbjct: 516 YSIV-----------------KYQPSEYGSYRFPPWAELLGILMGLLSCLMIPAGMLVAV 558

Query: 606 IR 607
           +R
Sbjct: 559 LR 560


>gi|171184408 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  377 bits (968), Expect = e-104
 Identities = 214/603 (35%), Positives = 313/603 (51%), Gaps = 81/603 (13%)

Query: 20  ELETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLV 79
           +L+  ++++   R +W NK +++L+  G  +GLGNVWRFPYLC  +GGGAF IP+ I   
Sbjct: 24  KLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFF 83

Query: 80  LEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWY 139
           + GIP+ +LE A+GQ   +GS+  W  I P  +G+GLAS++    + +YY  I++W ++Y
Sbjct: 84  VCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFY 143

Query: 140 LFNSFQEPLPWSDCP-----------LNENQTGYVDECAR-SSPVDYFWYRETLNISTSI 187
           LF+SF   LPW+ C            LN +  G V      +SPV  FW R  L I++ I
Sbjct: 144 LFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGI 203

Query: 188 SDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGA 247
            D GS++W + LCL  AW + Y C  +G+++TGK VY T+T PY++L I LIRG+TL GA
Sbjct: 204 HDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGA 263

Query: 248 TNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVS 307
             GI++   P++  L  P  W+DAG Q+FFSF++  G L +  SYN  HNNC KD + + 
Sbjct: 264 YQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALC 323

Query: 308 IINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRC 367
            +N  TS     VV+S++GF                           ++QE  V + +  
Sbjct: 324 FLNSATSFVAGFVVFSILGF---------------------------MSQEQGVPISE-- 354

Query: 368 NASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCL 427
                                   A  G GLAFI F +A+T MPLS LWS LFFIML  L
Sbjct: 355 -----------------------VAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFL 391

Query: 428 GLSSMFGNMEGVVVPLQDL--RVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLL 485
           GL S F  +E +V    D+  R +     +E+L   I +  +LIG       G Y   L 
Sbjct: 392 GLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLF 451

Query: 486 DSYAGS-IPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLI 544
           D YA S I LL ++  E+  + +VYG DRF  +IE MIG++P    +++W  ++P L L 
Sbjct: 452 DYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLA 511

Query: 545 IFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYK 604
            FLF                  Y     +    YP W Y +   +A    + +P + +  
Sbjct: 512 TFLFSL--------------SKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVIT 557

Query: 605 LIR 607
           L++
Sbjct: 558 LLK 560


>gi|171184406 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  377 bits (968), Expect = e-104
 Identities = 214/603 (35%), Positives = 313/603 (51%), Gaps = 81/603 (13%)

Query: 20  ELETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLV 79
           +L+  ++++   R +W NK +++L+  G  +GLGNVWRFPYLC  +GGGAF IP+ I   
Sbjct: 24  KLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFF 83

Query: 80  LEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWY 139
           + GIP+ +LE A+GQ   +GS+  W  I P  +G+GLAS++    + +YY  I++W ++Y
Sbjct: 84  VCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFY 143

Query: 140 LFNSFQEPLPWSDCP-----------LNENQTGYVDECAR-SSPVDYFWYRETLNISTSI 187
           LF+SF   LPW+ C            LN +  G V      +SPV  FW R  L I++ I
Sbjct: 144 LFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGI 203

Query: 188 SDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGA 247
            D GS++W + LCL  AW + Y C  +G+++TGK VY T+T PY++L I LIRG+TL GA
Sbjct: 204 HDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGA 263

Query: 248 TNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVS 307
             GI++   P++  L  P  W+DAG Q+FFSF++  G L +  SYN  HNNC KD + + 
Sbjct: 264 YQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALC 323

Query: 308 IINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRC 367
            +N  TS     VV+S++GF                           ++QE  V + +  
Sbjct: 324 FLNSATSFVAGFVVFSILGF---------------------------MSQEQGVPISE-- 354

Query: 368 NASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCL 427
                                   A  G GLAFI F +A+T MPLS LWS LFFIML  L
Sbjct: 355 -----------------------VAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFL 391

Query: 428 GLSSMFGNMEGVVVPLQDL--RVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLL 485
           GL S F  +E +V    D+  R +     +E+L   I +  +LIG       G Y   L 
Sbjct: 392 GLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLF 451

Query: 486 DSYAGS-IPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLI 544
           D YA S I LL ++  E+  + +VYG DRF  +IE MIG++P    +++W  ++P L L 
Sbjct: 452 DYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLA 511

Query: 545 IFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYK 604
            FLF                  Y     +    YP W Y +   +A    + +P + +  
Sbjct: 512 TFLFSL--------------SKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVIT 557

Query: 605 LIR 607
           L++
Sbjct: 558 LLK 560


>gi|171184404 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  377 bits (968), Expect = e-104
 Identities = 214/603 (35%), Positives = 313/603 (51%), Gaps = 81/603 (13%)

Query: 20  ELETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLV 79
           +L+  ++++   R +W NK +++L+  G  +GLGNVWRFPYLC  +GGGAF IP+ I   
Sbjct: 24  KLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFF 83

Query: 80  LEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWY 139
           + GIP+ +LE A+GQ   +GS+  W  I P  +G+GLAS++    + +YY  I++W ++Y
Sbjct: 84  VCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFY 143

Query: 140 LFNSFQEPLPWSDCP-----------LNENQTGYVDECAR-SSPVDYFWYRETLNISTSI 187
           LF+SF   LPW+ C            LN +  G V      +SPV  FW R  L I++ I
Sbjct: 144 LFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGI 203

Query: 188 SDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGA 247
            D GS++W + LCL  AW + Y C  +G+++TGK VY T+T PY++L I LIRG+TL GA
Sbjct: 204 HDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGA 263

Query: 248 TNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVS 307
             GI++   P++  L  P  W+DAG Q+FFSF++  G L +  SYN  HNNC KD + + 
Sbjct: 264 YQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALC 323

Query: 308 IINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRC 367
            +N  TS     VV+S++GF                           ++QE  V + +  
Sbjct: 324 FLNSATSFVAGFVVFSILGF---------------------------MSQEQGVPISE-- 354

Query: 368 NASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCL 427
                                   A  G GLAFI F +A+T MPLS LWS LFFIML  L
Sbjct: 355 -----------------------VAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFL 391

Query: 428 GLSSMFGNMEGVVVPLQDL--RVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLL 485
           GL S F  +E +V    D+  R +     +E+L   I +  +LIG       G Y   L 
Sbjct: 392 GLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLF 451

Query: 486 DSYAGS-IPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLI 544
           D YA S I LL ++  E+  + +VYG DRF  +IE MIG++P    +++W  ++P L L 
Sbjct: 452 DYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLA 511

Query: 545 IFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYK 604
            FLF                  Y     +    YP W Y +   +A    + +P + +  
Sbjct: 512 TFLFSL--------------SKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVIT 557

Query: 605 LIR 607
           L++
Sbjct: 558 LLK 560


>gi|197276623 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  366 bits (940), Expect = e-101
 Identities = 210/613 (34%), Positives = 309/613 (50%), Gaps = 91/613 (14%)

Query: 23  TIEQEEASSRP----KWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILL 78
           T  ++EA  +P    KW +K  ++L+  G  VGLGNVWRFPYLC  +GGGAF+IP+ I L
Sbjct: 28  TRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFL 87

Query: 79  VLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMW 138
              G+P+ +LE  IGQ    G +  W  I P   G+G AS++   ++ +YY  I++W  +
Sbjct: 88  FGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATY 147

Query: 139 YLFNSFQEPLPWSDCPLNENQTGYVDECAR--------------SSPVDYFWYRETLNIS 184
           YLF SFQ+ LPW+ C  + N    +++  R              +SPV  FW R  L++S
Sbjct: 148 YLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLS 207

Query: 185 TSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTL 244
             I   GS++W + LCL   W V + C  +G+ +TGK VY T+T P+ +L + L+RGLTL
Sbjct: 208 PGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTL 267

Query: 245 KGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSV 304
            GA  GI F   P++T L  P  W+DAG Q+FFS+++  G + S  SYN    N  +D +
Sbjct: 268 PGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCM 327

Query: 305 IVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQ 364
           ++  +N  TS      ++S++GF A                           QE  VD+ 
Sbjct: 328 LLGCLNSGTSFVSGFAIFSILGFMA---------------------------QEQGVDI- 359

Query: 365 QRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIML 424
                              D+      A  G GLAFI + +A+T MPL   WS+LFFIML
Sbjct: 360 ------------------ADV------AESGPGLAFIAYPKAVTMMPLPTFWSILFFIML 395

Query: 425 FCLGLSSMFGNMEGVVVPLQDL--RVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWL 482
             LGL S F  +EG +  L DL    +   + +E+    +C  ++L+G       G Y  
Sbjct: 396 LLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVF 455

Query: 483 SLLDSYAGS-IPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLL 541
            L D YA S + LL +AF E F + ++YG D     IE MIG++P  + + +W V++P+L
Sbjct: 456 QLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVL 515

Query: 542 MLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYA 601
            +  F+F  V  V   LTY            ++   YPNW   +   +A    L +P   
Sbjct: 516 CVGCFIFSLVKYV--PLTY------------NKTYVYPNWAIGLGWSLALSSMLCVPLVI 561

Query: 602 IYKLIRNHCQKPG 614
           + +L    CQ  G
Sbjct: 562 VIRL----CQTEG 570


>gi|54607094 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  366 bits (940), Expect = e-101
 Identities = 210/613 (34%), Positives = 309/613 (50%), Gaps = 91/613 (14%)

Query: 23  TIEQEEASSRP----KWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILL 78
           T  ++EA  +P    KW +K  ++L+  G  VGLGNVWRFPYLC  +GGGAF+IP+ I L
Sbjct: 28  TRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFL 87

Query: 79  VLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMW 138
              G+P+ +LE  IGQ    G +  W  I P   G+G AS++   ++ +YY  I++W  +
Sbjct: 88  FGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATY 147

Query: 139 YLFNSFQEPLPWSDCPLNENQTGYVDECAR--------------SSPVDYFWYRETLNIS 184
           YLF SFQ+ LPW+ C  + N    +++  R              +SPV  FW R  L++S
Sbjct: 148 YLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLS 207

Query: 185 TSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTL 244
             I   GS++W + LCL   W V + C  +G+ +TGK VY T+T P+ +L + L+RGLTL
Sbjct: 208 PGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTL 267

Query: 245 KGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSV 304
            GA  GI F   P++T L  P  W+DAG Q+FFS+++  G + S  SYN    N  +D +
Sbjct: 268 PGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCM 327

Query: 305 IVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQ 364
           ++  +N  TS      ++S++GF A                           QE  VD+ 
Sbjct: 328 LLGCLNSGTSFVSGFAIFSILGFMA---------------------------QEQGVDI- 359

Query: 365 QRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIML 424
                              D+      A  G GLAFI + +A+T MPL   WS+LFFIML
Sbjct: 360 ------------------ADV------AESGPGLAFIAYPKAVTMMPLPTFWSILFFIML 395

Query: 425 FCLGLSSMFGNMEGVVVPLQDL--RVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWL 482
             LGL S F  +EG +  L DL    +   + +E+    +C  ++L+G       G Y  
Sbjct: 396 LLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVF 455

Query: 483 SLLDSYAGS-IPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLL 541
            L D YA S + LL +AF E F + ++YG D     IE MIG++P  + + +W V++P+L
Sbjct: 456 QLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVL 515

Query: 542 MLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYA 601
            +  F+F  V  V   LTY            ++   YPNW   +   +A    L +P   
Sbjct: 516 CVGCFIFSLVKYV--PLTY------------NKTYVYPNWAIGLGWSLALSSMLCVPLVI 561

Query: 602 IYKLIRNHCQKPG 614
           + +L    CQ  G
Sbjct: 562 VIRL----CQTEG 570


>gi|4507043 solute carrier family 6 member 4 [Homo sapiens]
          Length = 630

 Score =  366 bits (939), Expect = e-101
 Identities = 204/619 (32%), Positives = 313/619 (50%), Gaps = 92/619 (14%)

Query: 7   PNPGLDARIPSLAELETIEQE-EASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSH 65
           P  G D R    A   T+  E     R  W  K  ++L+ +G+ V LGNVWRFPY+C  +
Sbjct: 53  PGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQN 112

Query: 66  GGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMV 125
           GGGAF++P+ I+ +  GIPL Y+E A+GQ  R G + +W  I P  KG+G A  + +F +
Sbjct: 113 GGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYI 172

Query: 126 GLYYNTIISWIMWYLFNSFQEPLPWSDCPLNENQ---TGYVDE------CARSSPVDYFW 176
             YYNTI++W ++YL +SF + LPW+ C  + N    T Y  E         +SP + F+
Sbjct: 173 ASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFY 232

Query: 177 YRETLNI--STSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVL 234
            R  L I  S  + D G I W + LC+   ++V+Y    +G++T+GK V++T+T PY++L
Sbjct: 233 TRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIIL 292

Query: 235 TIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNS 294
           ++ L+RG TL GA  G++F   PN  +L +   W+DA AQ+FFS    FG L++F+SYN 
Sbjct: 293 SVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNK 352

Query: 295 VHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGN 354
            +NNC +D+++ S++N  TS     V+++V+G+ A  R +D                   
Sbjct: 353 FNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNED------------------- 393

Query: 355 VTQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTG--LAFIVFTEAITKMPL 412
                                             +SE  +  G  L FI + EAI  MP 
Sbjct: 394 ----------------------------------VSEVAKDAGPSLLFITYAEAIANMPA 419

Query: 413 SPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKE----VLTGLICLGTFL 468
           S  ++++FF+ML  LGL S F  +EGV+  + D    P  W K     VL  +I   T  
Sbjct: 420 STFFAIIFFLMLITLGLDSTFAGLEGVITAVLD--EFPHVWAKRRERFVLAVVI---TCF 474

Query: 469 IGFIFTLN-SGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPN 527
            G + TL   G Y + LL+ YA    +L +A  E  +V + YG+ +F +D++ M+G  P 
Sbjct: 475 FGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPG 534

Query: 528 IFWQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVV 587
            FW++ W  +SPL +L I   F +      L                + +YP W  ++  
Sbjct: 535 WFWRICWVAISPLFLLFIICSFLMSPPQLRLF---------------QYNYPYWSIILGY 579

Query: 588 IVAGVPSLTIPGYAIYKLI 606
            +     + IP Y  Y+LI
Sbjct: 580 CIGTSSFICIPTYIAYRLI 598


>gi|21361581 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 13 [Homo sapiens]
          Length = 602

 Score =  366 bits (939), Expect = e-101
 Identities = 207/605 (34%), Positives = 306/605 (50%), Gaps = 82/605 (13%)

Query: 16  PSLAELETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFL 75
           P    +E  E++    R  W+NK +++L+  G  +GLGNVWRFPYLC  +GGGAF IP+L
Sbjct: 16  PVYPVMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYL 75

Query: 76  ILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISW 135
           + L   GIP+  LE A+GQ   +G +  W  I P  +G+G AS +   ++ +YY  +++W
Sbjct: 76  VFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAW 135

Query: 136 IMWYLFNSFQEPLPWSDCPLNENQTGYVDECARS------------SPVDYFWYRETLNI 183
            ++YLF+SF   LPW  C  +E  T +  E  ++            SPV  FW R  L I
Sbjct: 136 ALFYLFSSFTIDLPWGGC-YHEWNTEHCMEFQKTNGSLNGTSENATSPVIEFWERRVLKI 194

Query: 184 STSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLT 243
           S  I   G+++W + LCL  AW + Y C  +G+++TGK VY T+T PY++L + LIRG+T
Sbjct: 195 SDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVT 254

Query: 244 LKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDS 303
           L GA  GI F   PN+T L  P  W+DAG Q+FFSF++  G L +  SYN  HNNC +D 
Sbjct: 255 LPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDC 314

Query: 304 VIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDM 363
           + +  +N  TS      ++S++GF                           ++QE  V +
Sbjct: 315 IALCFLNSGTSFVAGFAIFSILGF---------------------------MSQEQGVPI 347

Query: 364 QQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIM 423
            +                          A  G GLAFI +  A+  +P SPLW+  FF M
Sbjct: 348 SE-------------------------VAESGPGLAFIAYPRAVVMLPFSPLWACCFFFM 382

Query: 424 LFCLGLSSMFGNMEGVVVPLQDL--RVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYW 481
           +  LGL S F  +E +V  L D+   V   K  +EVL   + + +FL+G I     G Y 
Sbjct: 383 VVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYV 442

Query: 482 LSLLDSYAGS-IPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPL 540
             L D YA S + LL +A  E   V +VYG  RF  +IE MIG++P    +  W  ++P 
Sbjct: 443 FQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPA 502

Query: 541 LMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGY 600
           +    FLF  +               Y     ++K +YP W   +  ++A    + IP +
Sbjct: 503 VCTATFLFSLI--------------KYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAW 548

Query: 601 AIYKL 605
           ++Y+L
Sbjct: 549 SLYRL 553


>gi|7657587 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 11 [Homo sapiens]
          Length = 632

 Score =  362 bits (930), Expect = e-100
 Identities = 201/617 (32%), Positives = 316/617 (51%), Gaps = 82/617 (13%)

Query: 32  RPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFA 91
           R  W+NK +++L+  G  +GLGNVWRFPYLC  +GGGAF+IP+++  +  GIP+ +LE A
Sbjct: 50  RGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETA 109

Query: 92  IGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWS 151
           +GQ    G +  W  + P  +G+G A+ +    + +YY  I++W ++YL N F   LPW+
Sbjct: 110 LGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWA 169

Query: 152 DC-------------PLNENQTGYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWML 198
            C              LN +   +V     +SPV  FW    L IS  I   G+++W + 
Sbjct: 170 TCGHEWNTENCVEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELA 229

Query: 199 LCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPN 258
           LCL  AW++ Y C  +G ++TGK VY+T+T PY++L I LIRG+TL GA+ GI F   P+
Sbjct: 230 LCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPD 289

Query: 259 VTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVA 318
           ++ L+ P  W+DAG Q+FFS+++  G L +  SYN+ +NNC +D +++  +N  TS    
Sbjct: 290 LSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAG 349

Query: 319 IVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQL 378
             ++SV+GF A ++                 +P   V +                     
Sbjct: 350 FAIFSVLGFMAYEQ----------------GVPIAEVAE--------------------- 372

Query: 379 VFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEG 438
                           G GLAFI + +A+T MPLSPLW+ LFF+ML  LGL S F  +E 
Sbjct: 373 ---------------SGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVES 417

Query: 439 VVVPLQDL--RVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGS-IPLL 495
           +V  + D+  +V    + +E+L   + + ++ +G +     G Y   L DSYA S + LL
Sbjct: 418 LVTAVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLL 477

Query: 496 IIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVS 555
            +A  E   + +VYG +RF  +IE MIG++P    +  W +++P +   IF+FF +    
Sbjct: 478 FVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLI---- 533

Query: 556 QELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQKPGD 615
                      Y+    +   +YP W Y +  ++A    L IP +    + +     P  
Sbjct: 534 ----------KYKPLKYNNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEK 583

Query: 616 HQGLVSTLSTASMNGDL 632
            Q L +  +   M G L
Sbjct: 584 LQKLTTPSTDLKMRGKL 600


>gi|4507041 solute carrier family 6 (neurotransmitter transporter,
           dopamine), member 3 [Homo sapiens]
          Length = 620

 Score =  360 bits (925), Expect = 2e-99
 Identities = 212/603 (35%), Positives = 308/603 (51%), Gaps = 89/603 (14%)

Query: 28  EASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLY 87
           EA  R  W  K  ++L+ +GF V L NVWRFPYLC  +GGGAF++P+L+ +V+ G+PL Y
Sbjct: 56  EAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFY 115

Query: 88  LEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEP 147
           +E A+GQ  R G+ GVW  I P LKG+G   +L S  VG +YN II+W + YLF+SF   
Sbjct: 116 MELALGQFNREGAAGVWK-ICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTE 174

Query: 148 LPWSDCPLNENQTGYVD--------------ECARSSPVDYFWYRETLNISTS--ISDSG 191
           LPW  C  + N     D              +   ++P   ++ R  L++  S  I D G
Sbjct: 175 LPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLG 234

Query: 192 SIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGI 251
             +W +  CL     +LY    +G++T+GK V+IT+T+PYVVLT  L+RG+TL GA +GI
Sbjct: 235 PPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGI 294

Query: 252 VFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIING 311
               + +   L +   W+DA  QV FS  + FG LI+FSSYN   NNC +D+++ + IN 
Sbjct: 295 RAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINS 354

Query: 312 FTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASD 371
            TS     VV+S +G+ A +                  +P G+V                
Sbjct: 355 LTSFSSGFVVFSFLGYMAQKH----------------SVPIGDV---------------- 382

Query: 372 PAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSS 431
                               A +G GL FI++ EAI  +PLS  W+V+FFIML  LG+ S
Sbjct: 383 --------------------AKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDS 422

Query: 432 MFGNMEGVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGS 491
             G ME V+  L D   +  +  +E+ T  I L TFL+      N G Y  +LLD +A  
Sbjct: 423 AMGGMESVITGLIDEFQLLHR-HRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAG 481

Query: 492 IPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFV 551
             +L     E   V + YGV +F+ DI+ M G +P+++W++ W++VSP  +L      FV
Sbjct: 482 TSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLL------FV 535

Query: 552 VEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQ 611
           V VS     +   P Y  +       +P+W   +  ++A      +P YA YK     C 
Sbjct: 536 VVVS---IVTFRPPHYGAY------IFPDWANALGWVIATSSMAMVPIYAAYKF----CS 582

Query: 612 KPG 614
            PG
Sbjct: 583 LPG 585


>gi|55749589 solute carrier family 6, member 16 [Homo sapiens]
          Length = 736

 Score =  360 bits (923), Expect = 3e-99
 Identities = 204/621 (32%), Positives = 323/621 (52%), Gaps = 14/621 (2%)

Query: 22  ETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLE 81
           E  E E   +RP W +K +Y+L  +GF +    +WRF YL  + GG +F   ++ +L L 
Sbjct: 93  EKKESEVLLARPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLV 152

Query: 82  GIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLF 141
           G+PLL+LE A GQ +R+G +GVW  I P + G+G +S +  F++GLY+N + SWI++Y+ 
Sbjct: 153 GVPLLFLEMAAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMS 212

Query: 142 NSFQEPLPWSDCPLNENQTGYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCL 201
            SFQ P+PW  CPL  N +G+  EC R++P  YFWY++ L  S  I D GS  + ++L  
Sbjct: 213 QSFQFPVPWEKCPLTMNSSGFDPECERTTPSIYFWYQQALKASDRIEDGGSPVYSLVLPF 272

Query: 202 ACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTE 261
              W ++    I G+++TGK +Y+   LP  ++  F IR L L+GA  G+  L    +++
Sbjct: 273 FLCWCLVGAFMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAKFGLQQLVVAKISD 332

Query: 262 LAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVV 321
           +     W  AG QV  +  +  G + S +SY    NNC  D+ +VS+IN  T +      
Sbjct: 333 VYNMSVWSLAGGQVLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSVINLLTLLVFTSFN 392

Query: 322 YSVIGFRATQRYDDCFSTN---ILTLINGFDLPEGNVTQENFV----DMQQRCNASDPAA 374
           + V+GF AT     C   N   +L LIN   LP       N +     +     +  P  
Sbjct: 393 FCVLGFWATVITHRCCERNAEILLKLINLGKLPPDAKPPVNLLYNPTSIYNAWLSGLPQH 452

Query: 375 YAQLVFQ---TCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSS 431
              +V +    C+I     +A EG   AF+ F EA++ +P S  WS +FF+ML  +GLSS
Sbjct: 453 IKSMVLREVTECNIETQFLKASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSS 512

Query: 432 MFGNMEGVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGS 491
             G M+G++ PLQD      K  K ++ G+  L  F+ G  FT  SG Y++ LL  Y   
Sbjct: 513 AIGIMQGIITPLQDTFSFFRKHTKLLIVGVFLL-MFVCGLFFTRPSGSYFIRLLSDYWIV 571

Query: 492 IPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFV 551
            P++++   E  +V + YG  RF  D+  ++GH  +  +   W  + P+++LIIF+   V
Sbjct: 572 FPIIVVVVFETMAVSWAYGARRFLADLTILLGHPISPIFGWLWPHLCPVVLLIIFVTMMV 631

Query: 552 VEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQ 611
               + +TY  WD       K     YP W  ++++ +  +  L IP Y +Y  I     
Sbjct: 632 HLCMKPITYMSWD---SSTSKEVLRPYPPWALLLMITLFAIVILPIPAYFVYCRIHRIPF 688

Query: 612 KPGDHQGLVSTLSTASMNGDL 632
           +P    G ++  ++  ++  L
Sbjct: 689 RPKSGDGPMTASTSLPLSHQL 709


>gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo
           sapiens]
          Length = 635

 Score =  358 bits (918), Expect = 1e-98
 Identities = 193/542 (35%), Positives = 287/542 (52%), Gaps = 81/542 (14%)

Query: 32  RPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFA 91
           R  W  +  ++++C+GF VGLGNVWRFPYLC  +GGG F+IP++++ ++ GIP+ +LE +
Sbjct: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111

Query: 92  IGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWS 151
           +GQ ++ GS+ VW+ I P  KGLG ASM+  F    YY  +++W  +YL  SF   LPW+
Sbjct: 112 LGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170

Query: 152 DCPLNENQTGYVD-----ECA--------------RSSPVDYFWYRETLNISTSISDSGS 192
            C    N    V+     +CA              R SPV  FW  + L +S  +   G+
Sbjct: 171 TCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGA 230

Query: 193 IQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIV 252
           + W + LCL   W ++Y C  +G+++TGK VY T+T PYVVL + L+RG+ L GA +GI+
Sbjct: 231 LNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGII 290

Query: 253 FLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGF 312
           +   P+ ++L  P  W+DAG Q+FFS+++  G L +  SYN  +NNC KD++I+++IN  
Sbjct: 291 YYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSG 350

Query: 313 TSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDP 372
           TS +   VV                                                   
Sbjct: 351 TSFFAGFVV--------------------------------------------------- 359

Query: 373 AAYAQLVFQTCDINAFLSEAVE-GTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSS 431
             ++ L F   +    +S+  E G GLAFI +  A+T MP++PLW+ LFF ML  LGL S
Sbjct: 360 --FSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDS 417

Query: 432 MFGNMEGVVVPLQDLRVIPP----KWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDS 487
            F  +EG +  L DL  +P     ++ +E+   L C   F+I      + G Y   L D 
Sbjct: 418 QFVGVEGFITGLLDL--LPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDY 475

Query: 488 YAGS-IPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIF 546
           Y+ S   LL  AF E   V +VYG DRF  DI  MIG++P  + +  W   +PL+ + IF
Sbjct: 476 YSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIF 535

Query: 547 LF 548
           +F
Sbjct: 536 IF 537


>gi|6005715 solute carrier family 6 (amino acid transporter), member
           14 [Homo sapiens]
          Length = 642

 Score =  355 bits (910), Expect = 9e-98
 Identities = 211/647 (32%), Positives = 323/647 (49%), Gaps = 115/647 (17%)

Query: 25  EQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIP 84
           E +E   R  W  K+ Y+L+ +G+ VGLGNVWRFPYL  S+GGGAF+IP+ I+L L G+P
Sbjct: 29  ENDENQDRGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLP 88

Query: 85  LLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSF 144
           L +LE ++GQ    G + VW  I P  +G+G+  +L S  V +YYN II++ ++Y+F SF
Sbjct: 89  LFFLECSLGQFASLGPVSVWR-ILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASF 147

Query: 145 QEPLPWSDCPL----NENQTGYVDECARSS------------------------------ 170
           Q  LPW +C      N +++  V  C  S+                              
Sbjct: 148 QSELPWKNCSSWSDKNCSRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSEIY 207

Query: 171 -----PVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYI 225
                P + +W +  L  S+ ++++G I W++ LCL  AW ++     +GI+++GK VY 
Sbjct: 208 QPGQLPSEQYWNKVALQRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYF 267

Query: 226 TSTLPYVVLTIFLIRGLTLKGATNGIVFLF--TPNVTELAQPDTWLDAGAQVFFSFSLAF 283
           T+  PYVVL I L+RG TL+GA+ GI +      N T+L + + W DA  Q+F+S S+A+
Sbjct: 268 TALFPYVVLLILLVRGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAW 327

Query: 284 GGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILT 343
           GGL++ SSYN   NNC  D+++V + N  TSV+    ++S++G  A     +        
Sbjct: 328 GGLVALSSYNKFKNNCFSDAIVVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQ----V 383

Query: 344 LINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVF 403
           + +GFDL                                                AFI +
Sbjct: 384 VKSGFDL------------------------------------------------AFIAY 395

Query: 404 TEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTGLIC 463
            EA+ ++P  P WS+LFF ML  LGL S F ++E +   +QDL     K  +  +T   C
Sbjct: 396 PEALAQLPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFPKVMKKMRVPITLGCC 455

Query: 464 LGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIG 523
           L  FL+G +    +G YW+ L+D +     +LI A  E+  ++++YG +RF +D E MIG
Sbjct: 456 LVLFLLGLVCVTQAGIYWVHLIDHFCAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIG 515

Query: 524 HKPNIF---WQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPN 580
            K  IF   W+  W V++P+L++ IF++  V             P Y   P      YP+
Sbjct: 516 AKRWIFWLWWRACWFVITPILLIAIFIWSLV---------QFHRPNYGAIP------YPD 560

Query: 581 WVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQKPGDHQGLVSTLSTAS 627
           W   +   +     + IP  AI K+I+    K    Q L+S    AS
Sbjct: 561 WGVALGWCMIVFCIIWIPIMAIIKIIQ---AKGNIFQRLISCCRPAS 604


>gi|4557046 solute carrier family 6 member 2 [Homo sapiens]
          Length = 617

 Score =  354 bits (909), Expect = 1e-97
 Identities = 211/601 (35%), Positives = 305/601 (50%), Gaps = 96/601 (15%)

Query: 28  EASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLY 87
           +A  R  W  K  ++L+ +GF V L NVWRFPYLC  +GGGAF+IP+ + L++ G+PL Y
Sbjct: 52  DAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFY 111

Query: 88  LEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEP 147
           +E A+GQ  R G+  VW  I P  KG+G A +L +  VG YYN II+W ++YLF+SF   
Sbjct: 112 MELALGQYNREGAATVWK-ICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLN 170

Query: 148 LPWSDCPLNENQTGYVDECA---------------RSSPVDYFWYRETLNI--STSISDS 190
           LPW+DC    N     D                  + +P   F+ R  L++  S+ I D 
Sbjct: 171 LPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDI 230

Query: 191 GSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNG 250
           G  QW +LLCL     VLY    +G++T+GK V+IT+TLPY VL + L+ G+TL GA+NG
Sbjct: 231 GLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNG 290

Query: 251 IVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIIN 310
           I      +   L +   W+DA  Q+FFS    FG LI+F+SYN   NNC +D+++ S IN
Sbjct: 291 INAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSIN 350

Query: 311 GFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNAS 370
             TS      ++S++G+ A                                  + + N  
Sbjct: 351 CITSFVSGFAIFSILGYMA---------------------------------HEHKVNIE 377

Query: 371 DPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLS 430
           D                    A EG GL FI++ EAI+ +  S  W+V+FF+ML  LGL 
Sbjct: 378 D-------------------VATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLD 418

Query: 431 SMFGNMEGVVVPL-QDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYA 489
           S  G ME V+  L  D +V+  K  +++ T  +   TFL+        G Y L+LLD++A
Sbjct: 419 SSMGGMEAVITGLADDFQVL--KRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFA 476

Query: 490 GSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFF 549
               +L     E   V + YGVDRF+ DI+ M+G +P ++W++ W+ VSP  +L      
Sbjct: 477 AGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLL------ 530

Query: 550 FVVEVS----QELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKL 605
           FVV VS    + LTY  +              +P W   V   +A    + +P Y IYK 
Sbjct: 531 FVVVVSIINFKPLTYDDY-------------IFPPWANWVGWGIALSSMVLVPIYVIYKF 577

Query: 606 I 606
           +
Sbjct: 578 L 578


>gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo
           sapiens]
          Length = 520

 Score =  278 bits (711), Expect = 1e-74
 Identities = 162/478 (33%), Positives = 238/478 (49%), Gaps = 81/478 (16%)

Query: 96  LRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDCPL 155
           ++ GS+ VW+ I P  KGLG ASM+  F    YY  +++W  +YL  SF   LPW+ C  
Sbjct: 1   MKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGH 59

Query: 156 NENQTGYVD-----ECA--------------RSSPVDYFWYRETLNISTSISDSGSIQWW 196
             N    V+     +CA              R SPV  FW  + L +S  +   G++ W 
Sbjct: 60  TWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWE 119

Query: 197 MLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFT 256
           + LCL   W ++Y C  +G+++TGK VY T+T PYVVL + L+RG+ L GA +GI++   
Sbjct: 120 VTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLK 179

Query: 257 PNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVY 316
           P+ ++L  P  W+DAG Q+FFS+++  G L +  SYN  +NNC KD++I+++IN  TS +
Sbjct: 180 PDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFF 239

Query: 317 VAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYA 376
              VV                                                     ++
Sbjct: 240 AGFVV-----------------------------------------------------FS 246

Query: 377 QLVFQTCDINAFLSEAVE-GTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGN 435
            L F   +    +S+  E G GLAFI +  A+T MP++PLW+ LFF ML  LGL S F  
Sbjct: 247 ILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVG 306

Query: 436 MEGVVVPLQDLRVIPP----KWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGS 491
           +EG +  L DL  +P     ++ +E+   L C   F+I      + G Y   L D Y+ S
Sbjct: 307 VEGFITGLLDL--LPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSAS 364

Query: 492 -IPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLF 548
              LL  AF E   V +VYG DRF  DI  MIG++P  + +  W   +PL+ + IF+F
Sbjct: 365 GTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIF 422


>gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo
           sapiens]
          Length = 625

 Score =  267 bits (682), Expect = 3e-71
 Identities = 126/320 (39%), Positives = 191/320 (59%), Gaps = 30/320 (9%)

Query: 32  RPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFA 91
           R  W  +  ++++C+GF VGLGNVWRFPYLC  +GGG F+IP++++ ++ GIP+ +LE +
Sbjct: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111

Query: 92  IGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWS 151
           +GQ ++ GS+ VW+ I P  KGLG ASM+  F    YY  +++W  +YL  SF   LPW+
Sbjct: 112 LGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170

Query: 152 DCPLNENQTGYVD-----ECA--------------RSSPVDYFWYRETLNISTSISDSGS 192
            C    N    V+     +CA              R SPV  FW  + L +S  +   G+
Sbjct: 171 TCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGA 230

Query: 193 IQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIV 252
           + W + LCL   W ++Y C  +G+++TGK VY T+T PYVVL + L+RG+ L GA +GI+
Sbjct: 231 LNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGII 290

Query: 253 FLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGF 312
           +   P+ ++L  P  W+DAG Q+FFS+++  G L +  SYN  +NNC          NG 
Sbjct: 291 YYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNC---------YNG- 340

Query: 313 TSVYVAIVVYSVIGFRATQR 332
           TS +   VV+S++GF A ++
Sbjct: 341 TSFFAGFVVFSILGFMAAEQ 360



 Score =  112 bits (281), Expect = 8e-25
 Identities = 68/180 (37%), Positives = 97/180 (53%), Gaps = 8/180 (4%)

Query: 375 YAQLVFQTCDINAFLSEAVE-GTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMF 433
           ++ L F   +    +S+  E G GLAFI +  A+T MP++PLW+ LFF ML  LGL S F
Sbjct: 350 FSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQF 409

Query: 434 GNMEGVVVPLQDLRVIPP----KWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYA 489
             +EG +  L DL  +P     ++ +E+   L C   F+I      + G Y   L D Y+
Sbjct: 410 VGVEGFITGLLDL--LPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYS 467

Query: 490 GS-IPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLF 548
            S   LL  AF E   V +VYG DRF  DI  MIG++P  + +  W   +PL+ + IF+F
Sbjct: 468 ASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIF 527


>gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo
           sapiens]
          Length = 289

 Score =  243 bits (619), Expect = 5e-64
 Identities = 112/236 (47%), Positives = 158/236 (66%), Gaps = 5/236 (2%)

Query: 27  EEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLL 86
           E    RP W++K QY+L  +GF VGLGNVWRFPYLCQ +GGGA+++P+LILL++ GIPL 
Sbjct: 56  EVEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLF 115

Query: 87  YLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQE 146
           +LE ++GQR+RRGS+GVW+ I P L G+G AS +  + V LYYN II W ++Y   SFQ+
Sbjct: 116 FLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQ 175

Query: 147 PLPWSDCPL--NENQTGYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACA 204
           PLPW  CPL  N + T    EC +SS   Y+WYRE LNIS+SIS+SG + W M +CL  A
Sbjct: 176 PLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAA 235

Query: 205 WSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVT 260
           W ++ +  I+GI+++GK   ++   P+++L I +   + L  +        T N +
Sbjct: 236 WVMVCLAMIKGIQSSGK---VSMLEPFLILLITISGFIPLSNSVTDFCGQITHNTS 288


>gi|197276625 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform b [Homo sapiens]
          Length = 200

 Score =  136 bits (343), Expect = 5e-32
 Identities = 67/178 (37%), Positives = 103/178 (57%), Gaps = 10/178 (5%)

Query: 23  TIEQEEASSRP----KWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILL 78
           T  ++EA  +P    KW +K  ++L+  G  VGLGNVWRFPYLC  +GGGAF+IP+ I L
Sbjct: 28  TRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFL 87

Query: 79  VLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMW 138
              G+P+ +LE  IGQ    G +  W  I P   G+G AS++   ++ +YY  I++W  +
Sbjct: 88  FGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATY 147

Query: 139 YLFNSFQEPLPWSDCPLNENQTGYVDECARSSPVDYFWYRETLNISTSISDSGSIQWW 196
           YLF SFQ+ LPW+ C  + N    +++  R +   +      + IS++   S  I++W
Sbjct: 148 YLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVW------ITISSTNFTSPVIEFW 199


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.326    0.141    0.452 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,610,347
Number of Sequences: 37866
Number of extensions: 1016423
Number of successful extensions: 2998
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 2850
Number of HSP's gapped (non-prelim): 59
length of query: 634
length of database: 18,247,518
effective HSP length: 108
effective length of query: 526
effective length of database: 14,157,990
effective search space: 7447102740
effective search space used: 7447102740
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.