BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|50843827 activating molecule in beclin-1-regulated autophagy [Homo sapiens] (1208 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|50843827 activating molecule in beclin-1-regulated autophagy ... 2432 0.0 gi|23199987 WD repeat domain 5B [Homo sapiens] 65 4e-10 gi|16554629 WD repeat domain 5 [Homo sapiens] 63 2e-09 gi|16554627 WD repeat domain 5 [Homo sapiens] 63 2e-09 gi|216548382 WD repeat domain 47 isoform 3 [Homo sapiens] 57 8e-08 gi|216548378 WD repeat domain 47 isoform 1 [Homo sapiens] 57 8e-08 gi|216548347 WD repeat domain 47 isoform 2 [Homo sapiens] 57 8e-08 gi|113865883 WD repeat domain 38 [Homo sapiens] 54 9e-07 gi|32189425 WD repeat domain 69 [Homo sapiens] 54 1e-06 gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 52 3e-06 gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ... 52 4e-06 gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 52 4e-06 gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 51 6e-06 gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 49 3e-05 gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 49 3e-05 gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 49 3e-05 gi|21071067 TBP-associated factor 5 [Homo sapiens] 49 4e-05 gi|13376840 WD repeat domain 61 [Homo sapiens] 49 4e-05 gi|148536855 coatomer protein complex, subunit alpha isoform 1 [... 48 5e-05 gi|148536853 coatomer protein complex, subunit alpha isoform 2 [... 48 5e-05 gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 48 6e-05 gi|48762926 PWP2 periodic tryptophan protein homolog [Homo sapiens] 48 6e-05 gi|4557467 excision repair cross-complementing rodent repair def... 47 1e-04 gi|34915994 transducin-like enhancer protein 4 [Homo sapiens] 47 1e-04 gi|19913369 transducin beta-like 3 [Homo sapiens] 47 1e-04 gi|5174447 guanine nucleotide binding protein (G protein), beta ... 46 2e-04 gi|169403944 WD repeat domain 26 isoform b [Homo sapiens] 46 2e-04 gi|55743153 WD repeat domain 26 isoform a [Homo sapiens] 46 2e-04 gi|21541824 transducin-like enhancer protein 1 [Homo sapiens] 45 3e-04 gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 45 3e-04 >gi|50843827 activating molecule in beclin-1-regulated autophagy [Homo sapiens] Length = 1208 Score = 2432 bits (6303), Expect = 0.0 Identities = 1208/1208 (100%), Positives = 1208/1208 (100%) Query: 1 MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLA 60 MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLA Sbjct: 1 MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLA 60 Query: 61 FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV 120 FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV Sbjct: 61 FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV 120 Query: 121 RIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEM 180 RIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEM Sbjct: 121 RIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEM 180 Query: 181 ERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLL 240 ERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLL Sbjct: 181 ERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLL 240 Query: 241 HNFLHMLSSRSSGIQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGP 300 HNFLHMLSSRSSGIQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGP Sbjct: 241 HNFLHMLSSRSSGIQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGP 300 Query: 301 TRRSLGGPLSSHPSRYHREIAPGLTGSEWTRTVLSLNSRSEAESMPPPRTSASSVSLLSV 360 TRRSLGGPLSSHPSRYHREIAPGLTGSEWTRTVLSLNSRSEAESMPPPRTSASSVSLLSV Sbjct: 301 TRRSLGGPLSSHPSRYHREIAPGLTGSEWTRTVLSLNSRSEAESMPPPRTSASSVSLLSV 360 Query: 361 LRQQEGGSQASVYTSATEGRGFPASGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEY 420 LRQQEGGSQASVYTSATEGRGFPASGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEY Sbjct: 361 LRQQEGGSQASVYTSATEGRGFPASGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEY 420 Query: 421 DRLQELDQSLSGEAPQTQQAQEMLNNNIESERPGPSHQPTPHSSENNSNLSRGHLNRCRA 480 DRLQELDQSLSGEAPQTQQAQEMLNNNIESERPGPSHQPTPHSSENNSNLSRGHLNRCRA Sbjct: 421 DRLQELDQSLSGEAPQTQQAQEMLNNNIESERPGPSHQPTPHSSENNSNLSRGHLNRCRA 480 Query: 481 CHNLLTFNNDTLRWERTTPNYSSGEASSSWQVPSSFESVPSSGSQLPPLERTEGQTPSSS 540 CHNLLTFNNDTLRWERTTPNYSSGEASSSWQVPSSFESVPSSGSQLPPLERTEGQTPSSS Sbjct: 481 CHNLLTFNNDTLRWERTTPNYSSGEASSSWQVPSSFESVPSSGSQLPPLERTEGQTPSSS 540 Query: 541 RLELSSSASPQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLR 600 RLELSSSASPQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLR Sbjct: 541 RLELSSSASPQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLR 600 Query: 601 RRLLESSLISLSRYDGAGSREHPIYPDPARLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQ 660 RRLLESSLISLSRYDGAGSREHPIYPDPARLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQ Sbjct: 601 RRLLESSLISLSRYDGAGSREHPIYPDPARLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQ 660 Query: 661 NRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFL 720 NRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFL Sbjct: 661 NRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFL 720 Query: 721 LPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTKF 780 LPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTKF Sbjct: 721 LPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTKF 780 Query: 781 DLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRGFPDEGILAVYSLAPHN 840 DLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRGFPDEGILAVYSLAPHN Sbjct: 781 DLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRGFPDEGILAVYSLAPHN 840 Query: 841 LGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFRLQQAHGGETS 900 LGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFRLQQAHGGETS Sbjct: 841 LGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFRLQQAHGGETS 900 Query: 901 MRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNKGDLVICRPEALNSGVEYYWD 960 MRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNKGDLVICRPEALNSGVEYYWD Sbjct: 901 MRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNKGDLVICRPEALNSGVEYYWD 960 Query: 961 QLNETVFTVHSNSRSSERPGTSRATWRTDRDMGLMNAIGLQPRNPATSVTSQGTQTLALQ 1020 QLNETVFTVHSNSRSSERPGTSRATWRTDRDMGLMNAIGLQPRNPATSVTSQGTQTLALQ Sbjct: 961 QLNETVFTVHSNSRSSERPGTSRATWRTDRDMGLMNAIGLQPRNPATSVTSQGTQTLALQ 1020 Query: 1021 LQNAETQTEREVPEPGTAASGPGEGEGSEYGASGEDALSRIQRLMAEGGMTAVVQREQST 1080 LQNAETQTEREVPEPGTAASGPGEGEGSEYGASGEDALSRIQRLMAEGGMTAVVQREQST Sbjct: 1021 LQNAETQTEREVPEPGTAASGPGEGEGSEYGASGEDALSRIQRLMAEGGMTAVVQREQST 1080 Query: 1081 TMASMGGFGNNIIVSHRIHRSSQTGTEPGAAHTSSPQPSTSRGLLPEAGQLAERGLSPRT 1140 TMASMGGFGNNIIVSHRIHRSSQTGTEPGAAHTSSPQPSTSRGLLPEAGQLAERGLSPRT Sbjct: 1081 TMASMGGFGNNIIVSHRIHRSSQTGTEPGAAHTSSPQPSTSRGLLPEAGQLAERGLSPRT 1140 Query: 1141 ASWDQPGTPGREPTQPTLPSSSPVPIPVSLPSAEGPTLHCELTNNNHLLDGGSSRGDAAG 1200 ASWDQPGTPGREPTQPTLPSSSPVPIPVSLPSAEGPTLHCELTNNNHLLDGGSSRGDAAG Sbjct: 1141 ASWDQPGTPGREPTQPTLPSSSPVPIPVSLPSAEGPTLHCELTNNNHLLDGGSSRGDAAG 1200 Query: 1201 PRGEPRNR 1208 PRGEPRNR Sbjct: 1201 PRGEPRNR 1208 >gi|23199987 WD repeat domain 5B [Homo sapiens] Length = 330 Score = 65.1 bits (157), Expect = 4e-10 Identities = 47/140 (33%), Positives = 67/140 (47%), Gaps = 7/140 (5%) Query: 34 EDKTR--WMKWEGKRVE-LPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHS 90 +DKT W GK ++ L F F+P L+ S + + I EVKTGKC+ + Sbjct: 103 DDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKT 162 Query: 91 LIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGS--ESWFTDSNNAIASLAFHPT 148 L H V F+ + LI SG DG RIWD G ++ D N ++ + F P Sbjct: 163 LSAHSDPVSAVHFNCS-GSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPN 221 Query: 149 AQLLLIATA-NEIHFWDWSR 167 + +L AT N + WD+SR Sbjct: 222 GKYILTATLDNTLKLWDYSR 241 Score = 59.7 bits (143), Expect = 2e-08 Identities = 40/147 (27%), Positives = 79/147 (53%), Gaps = 8/147 (5%) Query: 59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDG 118 +A+S D + L S + + + +V++GKC+ +L GH +C F+P S LI SG D Sbjct: 89 VAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPP-SNLIISGSFDE 147 Query: 119 EVRIWDLHGGS-ESWFTDSNNAIASLAFHPTAQLLLIATANEI-HFWDWSRREPFAVVKT 176 V+IW++ G + ++ ++++ F+ + L++ + + + WD + + +KT Sbjct: 148 TVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQ---CLKT 204 Query: 177 ASEMER--VRLVRFDPLGHYLLTAIVN 201 + + V V+F P G Y+LTA ++ Sbjct: 205 LVDDDNPPVSFVKFSPNGKYILTATLD 231 Score = 43.1 bits (100), Expect = 0.002 Identities = 27/108 (25%), Positives = 53/108 (49%), Gaps = 4/108 (3%) Query: 51 DSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISG- 109 D+P +F+ FSP+ + + +++ + + + G+C+ + GH+ +C+ + +++G Sbjct: 209 DNPPVSFV-KFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGG 267 Query: 110 -LIASGCLDGEVRIWDLHGGS-ESWFTDSNNAIASLAFHPTAQLLLIA 155 I SG D V IW+L + + S A HPT L+ A Sbjct: 268 KWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASA 315 >gi|16554629 WD repeat domain 5 [Homo sapiens] Length = 334 Score = 62.8 bits (151), Expect = 2e-09 Identities = 43/147 (29%), Positives = 76/147 (51%), Gaps = 8/147 (5%) Query: 59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDG 118 +A+S D LL S + + I +V +GKC+ +L GH +C F+P S LI SG D Sbjct: 93 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ-SNLIVSGSFDE 151 Query: 119 EVRIWDLHGGS-ESWFTDSNNAIASLAFHPTAQLLLIATANEI-HFWDWSRREPFAVVKT 176 VRIWD+ G ++ ++++ F+ L++ ++ + + WD + + +KT Sbjct: 152 SVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ---CLKT 208 Query: 177 ASEMER--VRLVRFDPLGHYLLTAIVN 201 + + V V+F P G Y+L A ++ Sbjct: 209 LIDDDNPPVSFVKFSPNGKYILAATLD 235 Score = 62.4 bits (150), Expect = 3e-09 Identities = 46/146 (31%), Positives = 68/146 (46%), Gaps = 7/146 (4%) Query: 28 LLQELVEDKTR--WMKWEGKRVE-LPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKT 84 LL +DKT W GK ++ L F F+P L+ S + ++ I +VKT Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160 Query: 85 GKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGS--ESWFTDSNNAIAS 142 GKC+ +L H V F+ LI S DG RIWD G ++ D N ++ Sbjct: 161 GKCLKTLPAHSDPVSAVHFNRD-GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSF 219 Query: 143 LAFHPTAQLLLIATA-NEIHFWDWSR 167 + F P + +L AT N + WD+S+ Sbjct: 220 VKFSPNGKYILAATLDNTLKLWDYSK 245 Score = 43.5 bits (101), Expect = 0.001 Identities = 27/108 (25%), Positives = 53/108 (49%), Gaps = 4/108 (3%) Query: 51 DSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISG- 109 D+P +F+ FSP+ + + +++ + + + GKC+ + GH+ +C+ + +++G Sbjct: 213 DNPPVSFV-KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG 271 Query: 110 -LIASGCLDGEVRIWDLHGGS-ESWFTDSNNAIASLAFHPTAQLLLIA 155 I SG D V IW+L + + S A HPT ++ A Sbjct: 272 KWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASA 319 >gi|16554627 WD repeat domain 5 [Homo sapiens] Length = 334 Score = 62.8 bits (151), Expect = 2e-09 Identities = 43/147 (29%), Positives = 76/147 (51%), Gaps = 8/147 (5%) Query: 59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDG 118 +A+S D LL S + + I +V +GKC+ +L GH +C F+P S LI SG D Sbjct: 93 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ-SNLIVSGSFDE 151 Query: 119 EVRIWDLHGGS-ESWFTDSNNAIASLAFHPTAQLLLIATANEI-HFWDWSRREPFAVVKT 176 VRIWD+ G ++ ++++ F+ L++ ++ + + WD + + +KT Sbjct: 152 SVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ---CLKT 208 Query: 177 ASEMER--VRLVRFDPLGHYLLTAIVN 201 + + V V+F P G Y+L A ++ Sbjct: 209 LIDDDNPPVSFVKFSPNGKYILAATLD 235 Score = 62.4 bits (150), Expect = 3e-09 Identities = 46/146 (31%), Positives = 68/146 (46%), Gaps = 7/146 (4%) Query: 28 LLQELVEDKTR--WMKWEGKRVE-LPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKT 84 LL +DKT W GK ++ L F F+P L+ S + ++ I +VKT Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160 Query: 85 GKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGS--ESWFTDSNNAIAS 142 GKC+ +L H V F+ LI S DG RIWD G ++ D N ++ Sbjct: 161 GKCLKTLPAHSDPVSAVHFNRD-GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSF 219 Query: 143 LAFHPTAQLLLIATA-NEIHFWDWSR 167 + F P + +L AT N + WD+S+ Sbjct: 220 VKFSPNGKYILAATLDNTLKLWDYSK 245 Score = 43.5 bits (101), Expect = 0.001 Identities = 27/108 (25%), Positives = 53/108 (49%), Gaps = 4/108 (3%) Query: 51 DSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISG- 109 D+P +F+ FSP+ + + +++ + + + GKC+ + GH+ +C+ + +++G Sbjct: 213 DNPPVSFV-KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG 271 Query: 110 -LIASGCLDGEVRIWDLHGGS-ESWFTDSNNAIASLAFHPTAQLLLIA 155 I SG D V IW+L + + S A HPT ++ A Sbjct: 272 KWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASA 319 >gi|216548382 WD repeat domain 47 isoform 3 [Homo sapiens] Length = 919 Score = 57.4 bits (137), Expect = 8e-08 Identities = 50/150 (33%), Positives = 71/150 (47%), Gaps = 14/150 (9%) Query: 76 NIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGS-----E 130 NIY T+ + G+ +H+L GH T + + +IASG D VR WDL S Sbjct: 736 NIYTTDCQRGQGLHALSGH--TGHILALYTWSGWMIASGSQDKTVRFWDLRVPSCVRVVG 793 Query: 131 SWFTDSNNAIASLAFHPTAQLLLIATANE-IHFWDWSRREPFAVVKTASEMERVRLVRFD 189 + F + +A+AS+A P+ +LL AT E + R V VR VRF Sbjct: 794 TTFHGTGSAVASVAVDPSGRLL--ATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFS 851 Query: 190 PLGHYLLTAI----VNPSNQQGDDEPEIPI 215 P HYLLT + ++ QGD ++PI Sbjct: 852 PGAHYLLTGSYDMKIKVTDLQGDLTKQLPI 881 >gi|216548378 WD repeat domain 47 isoform 1 [Homo sapiens] Length = 927 Score = 57.4 bits (137), Expect = 8e-08 Identities = 50/150 (33%), Positives = 71/150 (47%), Gaps = 14/150 (9%) Query: 76 NIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGS-----E 130 NIY T+ + G+ +H+L GH T + + +IASG D VR WDL S Sbjct: 744 NIYTTDCQRGQGLHALSGH--TGHILALYTWSGWMIASGSQDKTVRFWDLRVPSCVRVVG 801 Query: 131 SWFTDSNNAIASLAFHPTAQLLLIATANE-IHFWDWSRREPFAVVKTASEMERVRLVRFD 189 + F + +A+AS+A P+ +LL AT E + R V VR VRF Sbjct: 802 TTFHGTGSAVASVAVDPSGRLL--ATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFS 859 Query: 190 PLGHYLLTAI----VNPSNQQGDDEPEIPI 215 P HYLLT + ++ QGD ++PI Sbjct: 860 PGAHYLLTGSYDMKIKVTDLQGDLTKQLPI 889 >gi|216548347 WD repeat domain 47 isoform 2 [Homo sapiens] Length = 920 Score = 57.4 bits (137), Expect = 8e-08 Identities = 50/150 (33%), Positives = 71/150 (47%), Gaps = 14/150 (9%) Query: 76 NIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGS-----E 130 NIY T+ + G+ +H+L GH T + + +IASG D VR WDL S Sbjct: 737 NIYTTDCQRGQGLHALSGH--TGHILALYTWSGWMIASGSQDKTVRFWDLRVPSCVRVVG 794 Query: 131 SWFTDSNNAIASLAFHPTAQLLLIATANE-IHFWDWSRREPFAVVKTASEMERVRLVRFD 189 + F + +A+AS+A P+ +LL AT E + R V VR VRF Sbjct: 795 TTFHGTGSAVASVAVDPSGRLL--ATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFS 852 Query: 190 PLGHYLLTAI----VNPSNQQGDDEPEIPI 215 P HYLLT + ++ QGD ++PI Sbjct: 853 PGAHYLLTGSYDMKIKVTDLQGDLTKQLPI 882 >gi|113865883 WD repeat domain 38 [Homo sapiens] Length = 314 Score = 53.9 bits (128), Expect = 9e-07 Identities = 35/106 (33%), Positives = 51/106 (48%), Gaps = 3/106 (2%) Query: 61 FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV 120 FSPD L AS + + + +V KC+ L GH+R+ V+F P S +ASG D V Sbjct: 71 FSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPD-SRQLASGGWDKRV 129 Query: 121 RIWDLHGGSE-SWFTDSNNAIASLAFHPTAQLLLIAT-ANEIHFWD 164 +WD+ G ++I S F PT L + + +H WD Sbjct: 130 MLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWD 175 Score = 48.9 bits (115), Expect = 3e-05 Identities = 33/114 (28%), Positives = 54/114 (47%), Gaps = 5/114 (4%) Query: 54 RSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIAS 113 RS ++FSPD LAS + + + +V++G+ + L+GHR + F PT++ +A+ Sbjct: 106 RSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVN-CLAT 164 Query: 114 GCLDGEVRIWDLH----GGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFW 163 G D V IWDL S + I+ L + + L + IH W Sbjct: 165 GSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIW 218 Score = 33.1 bits (74), Expect = 1.6 Identities = 19/59 (32%), Positives = 28/59 (47%), Gaps = 1/59 (1%) Query: 59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLD 117 +AFSPD LAS + + + + TGKC+ +L G F P ++ SG D Sbjct: 239 IAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPD-GKILVSGAAD 296 >gi|32189425 WD repeat domain 69 [Homo sapiens] Length = 415 Score = 53.5 bits (127), Expect = 1e-06 Identities = 34/130 (26%), Positives = 67/130 (51%), Gaps = 5/130 (3%) Query: 39 WMKWEGKRVELPDSPRST-FLLAFS-PDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRR 96 W G+ + + R+ + +AF+ P +A+ + + V+TGKC H+ GH Sbjct: 119 WDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTA 178 Query: 97 TPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNA-IASLAFHPTAQLLLIA 155 C++F+P S L+A+G +D ++WD+ G E + ++A I SL+F+ + ++ Sbjct: 179 EIVCLSFNPQ-STLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITG 237 Query: 156 TANE-IHFWD 164 + + + WD Sbjct: 238 SFDHTVVVWD 247 Score = 43.9 bits (102), Expect = 0.001 Identities = 34/141 (24%), Positives = 67/141 (47%), Gaps = 5/141 (3%) Query: 59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDG 118 L+F+ + + +H + + + TG+ V+ LIGH +F+ S LI +G +D Sbjct: 225 LSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS-LILTGSMDK 283 Query: 119 EVRIWD-LHGGSESWFTDSNNAIASLAFHPTAQLLLIATAN-EIHFWDWSRREPFAVVKT 176 ++WD +G + T ++ I F T +L+ A+A+ + + R+ + K Sbjct: 284 TCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRK--CIAKL 341 Query: 177 ASEMERVRLVRFDPLGHYLLT 197 + + F+P G++LLT Sbjct: 342 EGHEGEISKISFNPQGNHLLT 362 >gi|83779014 katanin p80 subunit B 1 [Homo sapiens] Length = 655 Score = 52.4 bits (124), Expect = 3e-06 Identities = 44/137 (32%), Positives = 61/137 (44%), Gaps = 7/137 (5%) Query: 59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDG 118 L F P +AS + NI + +++ CV GH + C+ F P +AS D Sbjct: 111 LDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPD-GKWLASAADDH 169 Query: 119 EVRIWDLHGGS-ESWFTDSNNAIASLAFHPTAQLLLIATANE-IHFWDWSRREPFAVVK- 175 V++WDL G S F + + FHP LL +++ I FWD E F VV Sbjct: 170 TVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD---LEKFQVVSC 226 Query: 176 TASEMERVRLVRFDPLG 192 E VR V F+P G Sbjct: 227 IEGEPGPVRSVLFNPDG 243 Score = 51.2 bits (121), Expect = 6e-06 Identities = 35/117 (29%), Positives = 49/117 (41%), Gaps = 2/117 (1%) Query: 59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDG 118 L FSPD LAS +H + + ++ GK + GH V FHP L+ASG D Sbjct: 153 LRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPN-EYLLASGSSDR 211 Query: 119 EVRIWDLHGGS-ESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVV 174 +R WDL S + S+ F+P L + + + W F VV Sbjct: 212 TIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVV 268 Score = 42.0 bits (97), Expect = 0.004 Identities = 32/139 (23%), Positives = 65/139 (46%), Gaps = 7/139 (5%) Query: 62 SPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVR 121 +P+ ++A + + +I + +++ K + +L+GH+ + FHP +ASG D ++ Sbjct: 73 TPEELIVAGSQ-SGSIRVWDLEAAKILRTLMGHKANICSLDFHP-YGEFVASGSQDTNIK 130 Query: 122 IWDL-HGGSESWFTDSNNAIASLAFHPTAQLLLIATANE-IHFWDWSRREPFAVVKTASE 179 +WD+ G + + A+ L F P + L A + + WD + + + + Sbjct: 131 LWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMS--EFPGH 188 Query: 180 MERVRLVRFDPLGHYLLTA 198 V +V F P YLL + Sbjct: 189 TGPVNVVEFHP-NEYLLAS 206 >gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo sapiens] Length = 421 Score = 51.6 bits (122), Expect = 4e-06 Identities = 42/140 (30%), Positives = 61/140 (43%), Gaps = 3/140 (2%) Query: 61 FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV 120 F D+ LLA+ N I I +V TGK + +L+ H +TF P S ++ S D + Sbjct: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195 Query: 121 RIWDL--HGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTAS 178 R+WDL G N + S AF P + +L A++ F W+ + + K Sbjct: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFL-WNMDKYTMIRKLEG 254 Query: 179 EMERVRLVRFDPLGHYLLTA 198 V F P G L TA Sbjct: 255 HHHDVVACDFSPDGALLATA 274 Score = 38.9 bits (89), Expect = 0.030 Identities = 21/69 (30%), Positives = 31/69 (44%), Gaps = 1/69 (1%) Query: 60 AFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGE 119 AFSPD ++L S + +++ + + L GH F P L+A+ D Sbjct: 221 AFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPD-GALLATASYDTR 279 Query: 120 VRIWDLHGG 128 V IWD H G Sbjct: 280 VYIWDPHNG 288 >gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] Length = 589 Score = 51.6 bits (122), Expect = 4e-06 Identities = 35/94 (37%), Positives = 47/94 (50%), Gaps = 4/94 (4%) Query: 35 DKT--RWMKWEGKRVELPDSPRSTFL-LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSL 91 DKT W +G V L R L LAFSP+ LAS + + + ++ +G L Sbjct: 447 DKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL 506 Query: 92 IGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDL 125 GH +TF P SGLIAS +D VR+WD+ Sbjct: 507 RGHTDNITSLTFSPD-SGLIASASMDNSVRVWDI 539 Score = 40.4 bits (93), Expect = 0.010 Identities = 28/106 (26%), Positives = 45/106 (42%), Gaps = 3/106 (2%) Query: 61 FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV 120 F P+ LA+ + + + + G V GHR + F P +AS D + Sbjct: 434 FHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPN-GKYLASAGEDQRL 492 Query: 121 RIWDLHGGS-ESWFTDSNNAIASLAFHPTAQLLLIATA-NEIHFWD 164 ++WDL G+ + I SL F P + L+ A+ N + WD Sbjct: 493 KLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538 >gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] Length = 631 Score = 51.2 bits (121), Expect = 6e-06 Identities = 34/137 (24%), Positives = 61/137 (44%), Gaps = 5/137 (3%) Query: 61 FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV 120 F P LA++ + + + ++ G C+ + GH R W T+H + +AS LD Sbjct: 402 FHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWH-SCGNFVASSSLDKTS 460 Query: 121 RIWDLHG-GSESWFTDSNNAIASLAFHPTAQLLLIATANE-IHFWDWSRREPFAVVKTAS 178 +IWD++ +++ S+ F P + LL ++A++ + WD R Sbjct: 461 KIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWD--ARTGICEQSLYG 518 Query: 179 EMERVRLVRFDPLGHYL 195 M + FDP GH + Sbjct: 519 HMHSINDAIFDPRGHMI 535 Score = 31.2 bits (69), Expect = 6.2 Identities = 29/116 (25%), Positives = 46/116 (39%), Gaps = 15/116 (12%) Query: 59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDG 118 + F P L ++ + + I + +TG C SL GH + F P +IAS G Sbjct: 484 IEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPR-GHMIASCDACG 542 Query: 119 EVRIWDLH-------------GGSESWFTDSNNAIASLAFHPTAQLLLIATANEIH 161 ++WD G+E F S +A + + LL + + EIH Sbjct: 543 VTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDL-KSGEIH 597 >gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] Length = 369 Score = 48.9 bits (115), Expect = 3e-05 Identities = 30/100 (30%), Positives = 54/100 (54%), Gaps = 4/100 (4%) Query: 61 FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV 120 FSPD L+ S + + + + + +CVHS H V FHP+ + + A+G +D V Sbjct: 115 FSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAG-MDNTV 173 Query: 121 RIWDL--HGGSESWFTDSNNAIASLAFHPTAQLLLIATAN 158 ++WD+ H + + S A+ L+FHP+ L+ A+++ Sbjct: 174 KVWDVRTHRLLQHYQLHS-AAVNGLSFHPSGNYLITASSD 212 Score = 37.4 bits (85), Expect = 0.087 Identities = 31/124 (25%), Positives = 57/124 (45%), Gaps = 5/124 (4%) Query: 77 IYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDS 136 + + +K + GH+ CV F P+ L+ASG D VRIW + ES + Sbjct: 5 LMVWHMKPQSRAYRFTGHKDAVTCVNFSPS-GHLLASGSRDKTVRIWVPNVKGESTVFRA 63 Query: 137 NNA-IASLAFHPTAQLLLIATANE-IHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHY 194 + A + S+ F Q + A+ ++ + W R++ + + + VR +F P G Sbjct: 64 HTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQK--FLFSLSQHINWVRCAKFSPDGRL 121 Query: 195 LLTA 198 +++A Sbjct: 122 IVSA 125 Score = 30.8 bits (68), Expect = 8.1 Identities = 18/65 (27%), Positives = 31/65 (47%), Gaps = 1/65 (1%) Query: 59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDG 118 L+F P L + + + I ++ G+ +++L GH+ V F T ASG D Sbjct: 197 LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRT-GEYFASGGSDE 255 Query: 119 EVRIW 123 +V +W Sbjct: 256 QVMVW 260 >gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] Length = 359 Score = 48.9 bits (115), Expect = 3e-05 Identities = 30/100 (30%), Positives = 54/100 (54%), Gaps = 4/100 (4%) Query: 61 FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV 120 FSPD L+ S + + + + + +CVHS H V FHP+ + + A+G +D V Sbjct: 153 FSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAG-MDNTV 211 Query: 121 RIWDL--HGGSESWFTDSNNAIASLAFHPTAQLLLIATAN 158 ++WD+ H + + S A+ L+FHP+ L+ A+++ Sbjct: 212 KVWDVRTHRLLQHYQLHS-AAVNGLSFHPSGNYLITASSD 250 Score = 41.6 bits (96), Expect = 0.005 Identities = 36/140 (25%), Positives = 65/140 (46%), Gaps = 5/140 (3%) Query: 61 FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV 120 FS + LAS ++ + + +K + GH+ CV F P+ L+ASG D V Sbjct: 27 FSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS-GHLLASGSRDKTV 85 Query: 121 RIWDLHGGSESWFTDSNNA-IASLAFHPTAQLLLIATANE-IHFWDWSRREPFAVVKTAS 178 RIW + ES ++ A + S+ F Q + A+ ++ + W R++ + + Sbjct: 86 RIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQK--FLFSLSQ 143 Query: 179 EMERVRLVRFDPLGHYLLTA 198 + VR +F P G +++A Sbjct: 144 HINWVRCAKFSPDGRLIVSA 163 Score = 30.8 bits (68), Expect = 8.1 Identities = 18/65 (27%), Positives = 31/65 (47%), Gaps = 1/65 (1%) Query: 59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDG 118 L+F P L + + + I ++ G+ +++L GH+ V F T ASG D Sbjct: 235 LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRT-GEYFASGGSDE 293 Query: 119 EVRIW 123 +V +W Sbjct: 294 QVMVW 298 >gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] Length = 407 Score = 48.9 bits (115), Expect = 3e-05 Identities = 30/100 (30%), Positives = 54/100 (54%), Gaps = 4/100 (4%) Query: 61 FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV 120 FSPD L+ S + + + + + +CVHS H V FHP+ + + A+G +D V Sbjct: 153 FSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAG-MDNTV 211 Query: 121 RIWDL--HGGSESWFTDSNNAIASLAFHPTAQLLLIATAN 158 ++WD+ H + + S A+ L+FHP+ L+ A+++ Sbjct: 212 KVWDVRTHRLLQHYQLHS-AAVNGLSFHPSGNYLITASSD 250 Score = 41.6 bits (96), Expect = 0.005 Identities = 36/140 (25%), Positives = 65/140 (46%), Gaps = 5/140 (3%) Query: 61 FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV 120 FS + LAS ++ + + +K + GH+ CV F P+ L+ASG D V Sbjct: 27 FSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS-GHLLASGSRDKTV 85 Query: 121 RIWDLHGGSESWFTDSNNA-IASLAFHPTAQLLLIATANE-IHFWDWSRREPFAVVKTAS 178 RIW + ES ++ A + S+ F Q + A+ ++ + W R++ + + Sbjct: 86 RIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQK--FLFSLSQ 143 Query: 179 EMERVRLVRFDPLGHYLLTA 198 + VR +F P G +++A Sbjct: 144 HINWVRCAKFSPDGRLIVSA 163 Score = 30.8 bits (68), Expect = 8.1 Identities = 18/65 (27%), Positives = 31/65 (47%), Gaps = 1/65 (1%) Query: 59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDG 118 L+F P L + + + I ++ G+ +++L GH+ V F T ASG D Sbjct: 235 LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRT-GEYFASGGSDE 293 Query: 119 EVRIW 123 +V +W Sbjct: 294 QVMVW 298 >gi|21071067 TBP-associated factor 5 [Homo sapiens] Length = 800 Score = 48.5 bits (114), Expect = 4e-05 Identities = 28/106 (26%), Positives = 47/106 (44%), Gaps = 3/106 (2%) Query: 61 FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV 120 F P+ +A+ + + + +V G CV GH+ +TF P +A+G DG V Sbjct: 635 FHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPN-GRFLATGATDGRV 693 Query: 121 RIWDL-HGGSESWFTDSNNAIASLAFHPTAQLLLIATA-NEIHFWD 164 +WD+ HG + + SL F ++L + N + WD Sbjct: 694 LLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739 Score = 45.4 bits (106), Expect = 3e-04 Identities = 38/149 (25%), Positives = 52/149 (34%), Gaps = 45/149 (30%) Query: 60 AFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPW-------------------- 99 +FSPDR L S+ + + + ++T C+ GH W Sbjct: 550 SFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVA 609 Query: 100 ----------------------CVTFHPTISGLIASGCLDGEVRIWD-LHGGSESWFTDS 136 C FHP S +A+G D VR+WD L+G FT Sbjct: 610 RLWATDHYQPLRIFAGHLADVNCTRFHPN-SNYVATGSADRTVRLWDVLNGNCVRIFTGH 668 Query: 137 NNAIASLAFHPTAQLLLI-ATANEIHFWD 164 I SL F P + L AT + WD Sbjct: 669 KGPIHSLTFSPNGRFLATGATDGRVLLWD 697 Score = 39.7 bits (91), Expect = 0.018 Identities = 29/99 (29%), Positives = 44/99 (44%), Gaps = 2/99 (2%) Query: 59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDG 118 L FSP+ LA+ + + + ++ G V L GH T + F ++ASG +D Sbjct: 675 LTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRD-GEILASGSMDN 733 Query: 119 EVRIWDLHGGSESWFTDS-NNAIASLAFHPTAQLLLIAT 156 VR+WD E TD A + +Q LL+ T Sbjct: 734 TVRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLGT 772 >gi|13376840 WD repeat domain 61 [Homo sapiens] Length = 305 Score = 48.5 bits (114), Expect = 4e-05 Identities = 37/130 (28%), Positives = 65/130 (50%), Gaps = 5/130 (3%) Query: 43 EGKRVELPDSPRSTFLL--AFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWC 100 E + E R F+L A+SPD LAS ++ I I ++ TGK +H+L GH Sbjct: 136 ESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRS 195 Query: 101 VTFHPTISGLIASGCLDGEVRIWDL-HGGSESWFTDSNNAIASLAFHPTAQLLLIATANE 159 +TF P S L+ + DG ++I+D+ H + + + ++AF P + +++++ Sbjct: 196 LTFSPD-SQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDK 254 Query: 160 -IHFWDWSRR 168 + WD R Sbjct: 255 SVKVWDVGTR 264 Score = 48.1 bits (113), Expect = 5e-05 Identities = 40/121 (33%), Positives = 63/121 (52%), Gaps = 5/121 (4%) Query: 39 WMKWEGKRVELPDS-PRSTFLLAFSPDRTLLAS-THVNHNIYITEVKTGKCVHSLIGHRR 96 W GK+++ D+ P + LAFSPD LA+ THV + I V++GK +SL + Sbjct: 91 WDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVG-KVNIFGVESGKKEYSLDTRGK 149 Query: 97 TPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSN-NAIASLAFHPTAQLLLIA 155 + + P +ASG +DG + I+D+ G + + I SL F P +QLL+ A Sbjct: 150 FILSIAYSPD-GKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTA 208 Query: 156 T 156 + Sbjct: 209 S 209 Score = 40.8 bits (94), Expect = 0.008 Identities = 33/146 (22%), Positives = 69/146 (47%), Gaps = 9/146 (6%) Query: 12 ILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRT----L 67 + WG + + + ++ ++D + KW +R++L S L S D + + Sbjct: 22 VAWGTNKKENS---ETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPI 78 Query: 68 LASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHG 127 AS+ ++ +I + +++ GK + S+ W + F P S +A+G G+V I+ + Sbjct: 79 AASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPD-SQYLATGTHVGKVNIFGVES 137 Query: 128 GSESWFTDSNNA-IASLAFHPTAQLL 152 G + + D+ I S+A+ P + L Sbjct: 138 GKKEYSLDTRGKFILSIAYSPDGKYL 163 Score = 38.9 bits (89), Expect = 0.030 Identities = 20/66 (30%), Positives = 36/66 (54%), Gaps = 1/66 (1%) Query: 59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDG 118 +AF PD T S+ + ++ + +V T CVH+ H+ W V ++ S +++ G D Sbjct: 238 VAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGD-DQ 296 Query: 119 EVRIWD 124 E+ I+D Sbjct: 297 EIHIYD 302 >gi|148536855 coatomer protein complex, subunit alpha isoform 1 [Homo sapiens] Length = 1233 Score = 48.1 bits (113), Expect = 5e-05 Identities = 31/85 (36%), Positives = 47/85 (55%), Gaps = 7/85 (8%) Query: 89 HSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDS----NNAIASLA 144 H L GH R FHPT+ LI SG D +V+IW ++ S++W D+ N ++ Sbjct: 199 HVLEGHDRGVNWAAFHPTMP-LIVSGADDRQVKIWRMN-ESKAWEVDTCRGHYNNVSCAV 256 Query: 145 FHPTAQLLLIATANE-IHFWDWSRR 168 FHP +L+L + ++ I WD S+R Sbjct: 257 FHPRQELILSNSEDKSIRVWDMSKR 281 Score = 42.7 bits (99), Expect = 0.002 Identities = 26/77 (33%), Positives = 36/77 (46%), Gaps = 4/77 (5%) Query: 51 DSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGL 110 D R+TF F + + S + I + ++ CV L GH C FHPT L Sbjct: 94 DYIRTTF---FHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPT-EDL 149 Query: 111 IASGCLDGEVRIWDLHG 127 + S LD VR+WD+ G Sbjct: 150 VVSASLDQTVRVWDISG 166 Score = 36.6 bits (83), Expect = 0.15 Identities = 26/108 (24%), Positives = 48/108 (44%), Gaps = 3/108 (2%) Query: 61 FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV 120 F + L S ++ I + K +C+ +L+GH FH ++ S D + Sbjct: 59 FHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWIL-SASDDQTI 117 Query: 121 RIWDLHGGS-ESWFTDSNNAIASLAFHPTAQLLLIATANE-IHFWDWS 166 R+W+ + T N+ + FHPT L++ A+ ++ + WD S Sbjct: 118 RVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDIS 165 >gi|148536853 coatomer protein complex, subunit alpha isoform 2 [Homo sapiens] Length = 1224 Score = 48.1 bits (113), Expect = 5e-05 Identities = 31/85 (36%), Positives = 47/85 (55%), Gaps = 7/85 (8%) Query: 89 HSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDS----NNAIASLA 144 H L GH R FHPT+ LI SG D +V+IW ++ S++W D+ N ++ Sbjct: 199 HVLEGHDRGVNWAAFHPTMP-LIVSGADDRQVKIWRMN-ESKAWEVDTCRGHYNNVSCAV 256 Query: 145 FHPTAQLLLIATANE-IHFWDWSRR 168 FHP +L+L + ++ I WD S+R Sbjct: 257 FHPRQELILSNSEDKSIRVWDMSKR 281 Score = 42.7 bits (99), Expect = 0.002 Identities = 26/77 (33%), Positives = 36/77 (46%), Gaps = 4/77 (5%) Query: 51 DSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGL 110 D R+TF F + + S + I + ++ CV L GH C FHPT L Sbjct: 94 DYIRTTF---FHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPT-EDL 149 Query: 111 IASGCLDGEVRIWDLHG 127 + S LD VR+WD+ G Sbjct: 150 VVSASLDQTVRVWDISG 166 Score = 36.6 bits (83), Expect = 0.15 Identities = 26/108 (24%), Positives = 48/108 (44%), Gaps = 3/108 (2%) Query: 61 FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV 120 F + L S ++ I + K +C+ +L+GH FH ++ S D + Sbjct: 59 FHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWIL-SASDDQTI 117 Query: 121 RIWDLHGGS-ESWFTDSNNAIASLAFHPTAQLLLIATANE-IHFWDWS 166 R+W+ + T N+ + FHPT L++ A+ ++ + WD S Sbjct: 118 RVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDIS 165 >gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo sapiens] Length = 514 Score = 47.8 bits (112), Expect = 6e-05 Identities = 31/116 (26%), Positives = 52/116 (44%), Gaps = 10/116 (8%) Query: 59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISG--------L 110 + + P LLAS + + I +K CVH L H + + + + PT G + Sbjct: 355 IKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLM 414 Query: 111 IASGCLDGEVRIWDLHGG-SESWFTDSNNAIASLAFHPTAQLLLIATANE-IHFWD 164 +AS D VR+WD+ G T + S+AF P + L + ++ +H W+ Sbjct: 415 LASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWN 470 >gi|48762926 PWP2 periodic tryptophan protein homolog [Homo sapiens] Length = 919 Score = 47.8 bits (112), Expect = 6e-05 Identities = 36/121 (29%), Positives = 58/121 (47%), Gaps = 12/121 (9%) Query: 52 SPRSTFLLAFSPDRT---LLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTIS 108 SPR T + D + + A + I++ ++TG+ + L GH + F+P + Sbjct: 455 SPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNP-MK 513 Query: 109 GLIASGCLDGEVRIWDLHGGSESWFTDSNNAIAS----LAFHPTAQLLLIATAN-EIHFW 163 ++AS D VR+WD+ +SW T A+ S + F P L +AT N +I FW Sbjct: 514 SVLASASWDKTVRLWDMF---DSWRTKETLALTSDALAVTFRPDGAELAVATLNSQITFW 570 Query: 164 D 164 D Sbjct: 571 D 571 Score = 31.6 bits (70), Expect = 4.8 Identities = 20/72 (27%), Positives = 33/72 (45%), Gaps = 1/72 (1%) Query: 55 STFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASG 114 S LA+SPD + + + + + +G C + H VTF T ++ + Sbjct: 375 SMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTAT-GYVVVTS 433 Query: 115 CLDGEVRIWDLH 126 +DG VR +DLH Sbjct: 434 SMDGTVRAFDLH 445 >gi|4557467 excision repair cross-complementing rodent repair deficiency, complementation group 8 isoform 1 [Homo sapiens] Length = 396 Score = 47.0 bits (110), Expect = 1e-04 Identities = 29/111 (26%), Positives = 49/111 (44%), Gaps = 18/111 (16%) Query: 77 IYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDL----------- 125 + + ++K+G C H L GHR+ V++ P ++A+ D V++WD+ Sbjct: 168 VQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLD 227 Query: 126 -HGGSESWFTDS-----NNAIASLAFHPTA-QLLLIATANEIHFWDWSRRE 169 H G +S +S N + L F LL + T N + W+ S E Sbjct: 228 QHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE 278 >gi|34915994 transducin-like enhancer protein 4 [Homo sapiens] Length = 773 Score = 47.0 bits (110), Expect = 1e-04 Identities = 33/113 (29%), Positives = 48/113 (42%), Gaps = 1/113 (0%) Query: 46 RVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHP 105 + EL S + + LA SPD + S + NI + ++ V GH C+ Sbjct: 570 KAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISN 629 Query: 106 TISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATAN 158 + L G LD VR WDL G + D + I SL + PT + L + N Sbjct: 630 DGTKLWTGG-LDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMEN 681 >gi|19913369 transducin beta-like 3 [Homo sapiens] Length = 808 Score = 47.0 bits (110), Expect = 1e-04 Identities = 32/101 (31%), Positives = 52/101 (51%), Gaps = 5/101 (4%) Query: 101 VTFHPTISGLIASGCLDGEVRIWDL--HGGSESWFTDSNNAIASLAFHP-TAQLLLIATA 157 + F PT S L+A+G DG VR+WD+ H G+ F S + +AFHP +LLL ++A Sbjct: 115 MAFDPT-STLLATGGCDGAVRVWDIVRHYGTHH-FRGSPGVVHLVAFHPDPTRLLLFSSA 172 Query: 158 NEIHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTA 198 + WS ++ + + V + F GH +L++ Sbjct: 173 TDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSS 213 Score = 41.6 bits (96), Expect = 0.005 Identities = 39/151 (25%), Positives = 62/151 (41%), Gaps = 11/151 (7%) Query: 59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIA-SGCLD 117 +AF P TLLA+ + + + ++ H G V FHP + L+ S D Sbjct: 115 MAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATD 174 Query: 118 GEVRIWDLHGGS-ESWFTDSNNAIASLAFHPTAQLLLIATANEI-HFWDWSRREPFAVVK 175 +R+W L S + T +A+ SLAF +L + ++I WD + V Sbjct: 175 AAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVP 234 Query: 176 TASEMERVRLVRFDPL--------GHYLLTA 198 +E L+ +P+ G Y LTA Sbjct: 235 VFESVEAAVLLPEEPVSQLGVKSPGLYFLTA 265 Score = 39.7 bits (91), Expect = 0.018 Identities = 45/189 (23%), Positives = 77/189 (40%), Gaps = 13/189 (6%) Query: 59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDG 118 +A +P+ LLA+ + + + + + GHRR WCV F P + ++A+ DG Sbjct: 485 VAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSP-MDQVLATASADG 543 Query: 119 EVRIWDLHGGS-ESWFTDSNNAIASLAF-HPTAQLLLIATANEIHFWDWSRREPFAVVKT 176 +++W L S F + ++ +AF QLL + + W E V Sbjct: 544 TIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNE--CVRTL 601 Query: 177 ASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRR 236 + ++V + L + LT D + D TE ++A + Q VR+ Sbjct: 602 DAHEDKVWGLHCSRLDDHALTG-------ASDSRVILWKDVTEAEQAEEQARQEEQVVRQ 654 Query: 237 TPLLHNFLH 245 L N LH Sbjct: 655 QE-LDNLLH 662 >gi|5174447 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 [Homo sapiens] Length = 317 Score = 45.8 bits (107), Expect = 2e-04 Identities = 33/106 (31%), Positives = 48/106 (45%), Gaps = 3/106 (2%) Query: 61 FSPDRT--LLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDG 118 FSP+ + ++ S + + + + K + IGH VT P S L ASG DG Sbjct: 156 FSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGS-LCASGGKDG 214 Query: 119 EVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWD 164 + +WDL+ G + D + I +L F P L AT I WD Sbjct: 215 QAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWD 260 >gi|169403944 WD repeat domain 26 isoform b [Homo sapiens] Length = 498 Score = 45.8 bits (107), Expect = 2e-04 Identities = 22/56 (39%), Positives = 33/56 (58%) Query: 68 LASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIW 123 +AS +H +YI ++ + L GH RT CV+++P I ++AS DG VRIW Sbjct: 423 IASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 478 >gi|55743153 WD repeat domain 26 isoform a [Homo sapiens] Length = 514 Score = 45.8 bits (107), Expect = 2e-04 Identities = 22/56 (39%), Positives = 33/56 (58%) Query: 68 LASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIW 123 +AS +H +YI ++ + L GH RT CV+++P I ++AS DG VRIW Sbjct: 439 IASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 494 >gi|21541824 transducin-like enhancer protein 1 [Homo sapiens] Length = 770 Score = 45.4 bits (106), Expect = 3e-04 Identities = 32/109 (29%), Positives = 47/109 (43%), Gaps = 1/109 (0%) Query: 46 RVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHP 105 + EL S + + LA SPD + S + NI + ++ V GH C+ Sbjct: 567 KAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISN 626 Query: 106 TISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLI 154 + L G LD VR WDL G + D + I SL + PT + L + Sbjct: 627 DGTKLWTGG-LDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAV 674 >gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] Length = 526 Score = 45.4 bits (106), Expect = 3e-04 Identities = 29/116 (25%), Positives = 52/116 (44%), Gaps = 10/116 (8%) Query: 59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCV--------TFHPTISGL 110 + + P LLAS + + I +K C+H L H + + + T +P + + Sbjct: 367 IKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIM 426 Query: 111 IASGCLDGEVRIWDLHGG-SESWFTDSNNAIASLAFHPTAQLLLIATANE-IHFWD 164 +AS D VR+WD+ G T + S+AF P + L + ++ +H W+ Sbjct: 427 LASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWN 482 Score = 38.9 bits (89), Expect = 0.030 Identities = 19/63 (30%), Positives = 32/63 (50%), Gaps = 1/63 (1%) Query: 67 LLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLH 126 +LAS + + + +++ G C H+L H+ + V F P +ASG D V IW+ Sbjct: 426 MLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPD-GKYLASGSFDKCVHIWNTQ 484 Query: 127 GGS 129 G+ Sbjct: 485 SGN 487 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.313 0.129 0.380 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 51,157,804 Number of Sequences: 37866 Number of extensions: 2604829 Number of successful extensions: 11629 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 87 Number of HSP's successfully gapped in prelim test: 360 Number of HSP's that attempted gapping in prelim test: 10329 Number of HSP's gapped (non-prelim): 1561 length of query: 1208 length of database: 18,247,518 effective HSP length: 114 effective length of query: 1094 effective length of database: 13,930,794 effective search space: 15240288636 effective search space used: 15240288636 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.9 bits) S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.