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Search of human proteins with 50345279
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50345279 claudin 18 isoform 2 [Homo sapiens]
(261 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50345279 claudin 18 isoform 2 [Homo sapiens] 527 e-150
gi|7705961 claudin 18 isoform 1 [Homo sapiens] 491 e-139
gi|183979973 claudin 19 isoform a [Homo sapiens] 149 2e-36
gi|183979975 claudin 19 isoform b [Homo sapiens] 147 9e-36
gi|153792186 claudin 7 [Homo sapiens] 141 5e-34
gi|10863887 claudin 1 [Homo sapiens] 137 9e-33
gi|33598916 claudin 10 isoform a [Homo sapiens] 134 1e-31
gi|5921465 claudin 10 isoform b [Homo sapiens] 133 1e-31
gi|225703142 claudin 14 [Homo sapiens] 125 5e-29
gi|21536294 claudin 14 [Homo sapiens] 125 5e-29
gi|225703138 claudin 14 [Homo sapiens] 125 5e-29
gi|6912314 claudin 14 [Homo sapiens] 125 5e-29
gi|225703140 claudin 14 [Homo sapiens] 125 5e-29
gi|153792768 claudin 6 [Homo sapiens] 122 2e-28
gi|4502875 claudin 3 [Homo sapiens] 122 4e-28
gi|4502877 claudin 4 [Homo sapiens] 120 2e-27
gi|7656981 claudin 15 [Homo sapiens] 117 8e-27
gi|195947374 claudin 5 [Homo sapiens] 115 3e-26
gi|195947372 claudin 5 [Homo sapiens] 115 3e-26
gi|231569235 claudin 10 isoform a_i1 [Homo sapiens] 114 9e-26
gi|40788011 claudin 8 [Homo sapiens] 114 1e-25
gi|169166402 PREDICTED: claudin-24-like [Homo sapiens] 112 2e-25
gi|6912316 claudin 17 [Homo sapiens] 112 2e-25
gi|169167239 PREDICTED: claudin-24-like [Homo sapiens] 111 7e-25
gi|169166931 PREDICTED: claudin-24-like [Homo sapiens] 111 7e-25
gi|11141861 claudin 9 [Homo sapiens] 110 1e-24
gi|47716519 claudin 20 [Homo sapiens] 106 2e-23
gi|162417973 claudin 22 [Homo sapiens] 105 4e-23
gi|9966781 claudin 2 [Homo sapiens] 104 7e-23
gi|10938016 claudin 11 [Homo sapiens] 95 5e-20
>gi|50345279 claudin 18 isoform 2 [Homo sapiens]
Length = 261
Score = 527 bits (1357), Expect = e-150
Identities = 261/261 (100%), Positives = 261/261 (100%)
Query: 1 MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGF 60
MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGF
Sbjct: 1 MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGF 60
Query: 61 TECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLT 120
TECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLT
Sbjct: 61 TECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLT 120
Query: 121 SGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWV 180
SGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWV
Sbjct: 121 SGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWV 180
Query: 181 AGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKI 240
AGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKI
Sbjct: 181 AGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKI 240
Query: 241 YDGGARTEDEVQSYPSKHDYV 261
YDGGARTEDEVQSYPSKHDYV
Sbjct: 241 YDGGARTEDEVQSYPSKHDYV 261
>gi|7705961 claudin 18 isoform 1 [Homo sapiens]
Length = 261
Score = 491 bits (1264), Expect = e-139
Identities = 240/261 (91%), Positives = 252/261 (96%)
Query: 1 MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGF 60
M+ T CQ + F++S++G+AG IAAT MD WSTQDLY+NPVT+VF Y+GLWRSCVR+SSGF
Sbjct: 1 MSTTTCQVVAFLLSILGLAGCIAATGMDMWSTQDLYDNPVTSVFQYEGLWRSCVRQSSGF 60
Query: 61 TECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLT 120
TECR YFT+LGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLT
Sbjct: 61 TECRPYFTILGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLT 120
Query: 121 SGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWV 180
SGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWV
Sbjct: 121 SGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWV 180
Query: 181 AGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKI 240
AGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKI
Sbjct: 181 AGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKI 240
Query: 241 YDGGARTEDEVQSYPSKHDYV 261
YDGGARTEDEVQSYPSKHDYV
Sbjct: 241 YDGGARTEDEVQSYPSKHDYV 261
>gi|183979973 claudin 19 isoform a [Homo sapiens]
Length = 224
Score = 149 bits (377), Expect = 2e-36
Identities = 78/223 (34%), Positives = 121/223 (54%), Gaps = 14/223 (6%)
Query: 1 MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPV-TAVFNYQGLWRSCVRESSG 59
MA + Q LG+ ++L G GIIA+T + QW + + TAV Y+GLW SC +S+G
Sbjct: 1 MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60
Query: 60 FTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTL 119
+C+ Y +LL L +Q+ RALM+V ++LG + +++S+ +KC R+G AK + +
Sbjct: 61 QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120
Query: 120 TSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGW 179
G +FI++GLC + VS +A ++ F+ + V RY FG ALFVGW
Sbjct: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPST-----------PVNARYEFGPALFVGW 169
Query: 180 VAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKP 222
+ GL ++GG +C C PE N Y + A +P
Sbjct: 170 ASAGLAVLGGSFLCCTCP--EPERPNSSPQPYRPGPSAAAREP 210
>gi|183979975 claudin 19 isoform b [Homo sapiens]
Length = 211
Score = 147 bits (371), Expect = 9e-36
Identities = 77/220 (35%), Positives = 119/220 (54%), Gaps = 14/220 (6%)
Query: 1 MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPV-TAVFNYQGLWRSCVRESSG 59
MA + Q LG+ ++L G GIIA+T + QW + + TAV Y+GLW SC +S+G
Sbjct: 1 MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60
Query: 60 FTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTL 119
+C+ Y +LL L +Q+ RALM+V ++LG + +++S+ +KC R+G AK + +
Sbjct: 61 QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120
Query: 120 TSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGW 179
G +FI++GLC + VS +A ++ F+ + V RY FG ALFVGW
Sbjct: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPST-----------PVNARYEFGPALFVGW 169
Query: 180 VAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVA 219
+ GL ++GG +C C PE N Y + A
Sbjct: 170 ASAGLAVLGGSFLCCTCP--EPERPNSSPQPYRPGPSAAA 207
>gi|153792186 claudin 7 [Homo sapiens]
Length = 211
Score = 141 bits (356), Expect = 5e-34
Identities = 77/221 (34%), Positives = 120/221 (54%), Gaps = 12/221 (5%)
Query: 1 MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLY-NNPVTAVFNYQGLWRSCVRESSG 59
MA + Q LGF ++L+G G++A T + QW +N +TA Y+GLW CV +S+G
Sbjct: 1 MANSGLQLLGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTG 60
Query: 60 FTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTL 119
C+ Y ++L L A LQA RALM+V +VLG + + V+ +KC R G + KA + +
Sbjct: 61 MMSCKMYDSVLALSAALQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAM 120
Query: 120 TSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGW 179
GI+FIV+GL A+ S + + +VT+F+ ++ T +Y FG A+F+GW
Sbjct: 121 GGGIIFIVAGLAALVACSWYGHQIVTDFY----------NPLIPT-NIKYEFGPAIFIGW 169
Query: 180 VAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAY 220
L ++GG ++ +C G + SY S S Y
Sbjct: 170 AGSALVILGGALLSCSCPGNESKAGYRVPRSYPKSNSSKEY 210
>gi|10863887 claudin 1 [Homo sapiens]
Length = 211
Score = 137 bits (345), Expect = 9e-33
Identities = 71/197 (36%), Positives = 110/197 (55%), Gaps = 12/197 (6%)
Query: 1 MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLY-NNPVTAVFNYQGLWRSCVRESSG 59
MA Q LGF+++ +G G I +T + QW +N VTA Y+GLW SCV +S+G
Sbjct: 1 MANAGLQLLGFILAFLGWIGAIVSTALPQWRIYSYAGDNIVTAQAMYEGLWMSCVSQSTG 60
Query: 60 FTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTL 119
+C+ + +LL L + LQA RALM+VGI+LG I + V+ +KC++ ++ K M +
Sbjct: 61 QIQCKVFDSLLNLSSTLQATRALMVVGILLGVIAIFVATVGMKCMKCLEDDEVQKMRMAV 120
Query: 120 TSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGW 179
G +F+++GL + + + N +V F+ + V RY FG ALF GW
Sbjct: 121 IGGAIFLLAGLAILVATAWYGNRIVQEFY-----------DPMTPVNARYEFGQALFTGW 169
Query: 180 VAGGLTLIGGVMMCIAC 196
A L L+GG ++C +C
Sbjct: 170 AAASLCLLGGALLCCSC 186
>gi|33598916 claudin 10 isoform a [Homo sapiens]
Length = 226
Score = 134 bits (336), Expect = 1e-31
Identities = 80/241 (33%), Positives = 121/241 (50%), Gaps = 37/241 (15%)
Query: 17 GIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECRGYFTLLGLPAML 76
G ++AAT ++W ++ +TA + YQGLW +C + G CR +FT+ + +
Sbjct: 15 GFGALVAATTSNEWKVTTRASSVITATWVYQGLWMNCAGNALGSFHCRPHFTIFKVAGYI 74
Query: 77 QAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGV 136
QA R LMI + LG G + ++F +KC ++G D AKA + +GI+FI+SGLC++ G
Sbjct: 75 QACRGLMIAAVSLGFFGSIFALFGMKCTKVGG-SDKAKAKIACLAGIVFILSGLCSMTGC 133
Query: 137 SVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIAC 196
S++AN + T F+ V+ +Y GAALF+GW L +IGGV+ C +
Sbjct: 134 SLYANKITTEFFDPL------------FVEQKYELGAALFIGWAGASLCIIGGVIFCFSI 181
Query: 197 RGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPS 256
N K Y +G A++ S TK Y GG ED + PS
Sbjct: 182 ------SDNNKTPRYTYNG-----------ATSVMSSRTK----YHGG---EDFKTTNPS 217
Query: 257 K 257
K
Sbjct: 218 K 218
>gi|5921465 claudin 10 isoform b [Homo sapiens]
Length = 228
Score = 133 bits (335), Expect = 1e-31
Identities = 82/257 (31%), Positives = 128/257 (49%), Gaps = 37/257 (14%)
Query: 1 MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGF 60
MA TA + + F+VS+ G + + D W + +T + LW++CV +S+G
Sbjct: 1 MASTASEIIAFMVSISGWVLVSSTLPTDYWKVSTIDGTVITTATYWANLWKACVTDSTGV 60
Query: 61 TECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLT 120
+ C+ + ++L L +QA R LMI + LG G + ++F +KC ++G D AKA +
Sbjct: 61 SNCKDFPSMLALDGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGG-SDKAKAKIACL 119
Query: 121 SGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWV 180
+GI+FI+SGLC++ G S++AN + T F+ V+ +Y GAALF+GW
Sbjct: 120 AGIVFILSGLCSMTGCSLYANKITTEFFDPL------------FVEQKYELGAALFIGWA 167
Query: 181 AGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKI 240
L +IGGV+ C + N K Y +G A++ S TK
Sbjct: 168 GASLCIIGGVIFCFSI------SDNNKTPRYTYNG-----------ATSVMSSRTK---- 206
Query: 241 YDGGARTEDEVQSYPSK 257
Y GG ED + PSK
Sbjct: 207 YHGG---EDFKTTNPSK 220
>gi|225703142 claudin 14 [Homo sapiens]
Length = 239
Score = 125 bits (313), Expect = 5e-29
Identities = 71/202 (35%), Positives = 113/202 (55%), Gaps = 13/202 (6%)
Query: 1 MAVTACQGLGFVVSLIGIAGIIAATCMDQWS-TQDLYNNPVTAVFNYQGLWRSCVRESSG 59
MA TA Q LGF++S +G+ G + T + W T + N +TAV +GLW CV S+G
Sbjct: 1 MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTG 60
Query: 60 FTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTL 119
+C+ Y +LL LP LQA RALM++ +L I ++ +KC R + AK +
Sbjct: 61 IYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRC-AKGTPAKTTFAI 119
Query: 120 TSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGW 179
G +FI++GL + VS N +V NF+ + +GM ++ G AL++G+
Sbjct: 120 LGGTLFILAGLLCMVAVSWTTNDVVQNFY--NPLLPSGM---------KFEIGQALYLGF 168
Query: 180 VAGGLTLIGGVMMCIACRGLAP 201
++ L+LIGG ++C++C+ AP
Sbjct: 169 ISSSLSLIGGTLLCLSCQDEAP 190
>gi|21536294 claudin 14 [Homo sapiens]
Length = 239
Score = 125 bits (313), Expect = 5e-29
Identities = 71/202 (35%), Positives = 113/202 (55%), Gaps = 13/202 (6%)
Query: 1 MAVTACQGLGFVVSLIGIAGIIAATCMDQWS-TQDLYNNPVTAVFNYQGLWRSCVRESSG 59
MA TA Q LGF++S +G+ G + T + W T + N +TAV +GLW CV S+G
Sbjct: 1 MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTG 60
Query: 60 FTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTL 119
+C+ Y +LL LP LQA RALM++ +L I ++ +KC R + AK +
Sbjct: 61 IYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRC-AKGTPAKTTFAI 119
Query: 120 TSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGW 179
G +FI++GL + VS N +V NF+ + +GM ++ G AL++G+
Sbjct: 120 LGGTLFILAGLLCMVAVSWTTNDVVQNFY--NPLLPSGM---------KFEIGQALYLGF 168
Query: 180 VAGGLTLIGGVMMCIACRGLAP 201
++ L+LIGG ++C++C+ AP
Sbjct: 169 ISSSLSLIGGTLLCLSCQDEAP 190
>gi|225703138 claudin 14 [Homo sapiens]
Length = 239
Score = 125 bits (313), Expect = 5e-29
Identities = 71/202 (35%), Positives = 113/202 (55%), Gaps = 13/202 (6%)
Query: 1 MAVTACQGLGFVVSLIGIAGIIAATCMDQWS-TQDLYNNPVTAVFNYQGLWRSCVRESSG 59
MA TA Q LGF++S +G+ G + T + W T + N +TAV +GLW CV S+G
Sbjct: 1 MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTG 60
Query: 60 FTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTL 119
+C+ Y +LL LP LQA RALM++ +L I ++ +KC R + AK +
Sbjct: 61 IYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRC-AKGTPAKTTFAI 119
Query: 120 TSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGW 179
G +FI++GL + VS N +V NF+ + +GM ++ G AL++G+
Sbjct: 120 LGGTLFILAGLLCMVAVSWTTNDVVQNFY--NPLLPSGM---------KFEIGQALYLGF 168
Query: 180 VAGGLTLIGGVMMCIACRGLAP 201
++ L+LIGG ++C++C+ AP
Sbjct: 169 ISSSLSLIGGTLLCLSCQDEAP 190
>gi|6912314 claudin 14 [Homo sapiens]
Length = 239
Score = 125 bits (313), Expect = 5e-29
Identities = 71/202 (35%), Positives = 113/202 (55%), Gaps = 13/202 (6%)
Query: 1 MAVTACQGLGFVVSLIGIAGIIAATCMDQWS-TQDLYNNPVTAVFNYQGLWRSCVRESSG 59
MA TA Q LGF++S +G+ G + T + W T + N +TAV +GLW CV S+G
Sbjct: 1 MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTG 60
Query: 60 FTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTL 119
+C+ Y +LL LP LQA RALM++ +L I ++ +KC R + AK +
Sbjct: 61 IYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRC-AKGTPAKTTFAI 119
Query: 120 TSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGW 179
G +FI++GL + VS N +V NF+ + +GM ++ G AL++G+
Sbjct: 120 LGGTLFILAGLLCMVAVSWTTNDVVQNFY--NPLLPSGM---------KFEIGQALYLGF 168
Query: 180 VAGGLTLIGGVMMCIACRGLAP 201
++ L+LIGG ++C++C+ AP
Sbjct: 169 ISSSLSLIGGTLLCLSCQDEAP 190
>gi|225703140 claudin 14 [Homo sapiens]
Length = 239
Score = 125 bits (313), Expect = 5e-29
Identities = 71/202 (35%), Positives = 113/202 (55%), Gaps = 13/202 (6%)
Query: 1 MAVTACQGLGFVVSLIGIAGIIAATCMDQWS-TQDLYNNPVTAVFNYQGLWRSCVRESSG 59
MA TA Q LGF++S +G+ G + T + W T + N +TAV +GLW CV S+G
Sbjct: 1 MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTG 60
Query: 60 FTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTL 119
+C+ Y +LL LP LQA RALM++ +L I ++ +KC R + AK +
Sbjct: 61 IYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRC-AKGTPAKTTFAI 119
Query: 120 TSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGW 179
G +FI++GL + VS N +V NF+ + +GM ++ G AL++G+
Sbjct: 120 LGGTLFILAGLLCMVAVSWTTNDVVQNFY--NPLLPSGM---------KFEIGQALYLGF 168
Query: 180 VAGGLTLIGGVMMCIACRGLAP 201
++ L+LIGG ++C++C+ AP
Sbjct: 169 ISSSLSLIGGTLLCLSCQDEAP 190
>gi|153792768 claudin 6 [Homo sapiens]
Length = 220
Score = 122 bits (307), Expect = 2e-28
Identities = 73/226 (32%), Positives = 120/226 (53%), Gaps = 13/226 (5%)
Query: 1 MAVTACQGLGFVVSLIGIAGIIAATCMDQWS-TQDLYNNPVTAVFNYQGLWRSCVRESSG 59
MA Q LG V++L+G + + + W T + N+ V A ++GLW SCV +S+G
Sbjct: 1 MASAGMQILGVVLTLLGWVNGLVSCALPMWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTG 60
Query: 60 FTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTL 119
+C+ Y +LL LP LQA RAL ++ +++ GLLV + KC +DS KA + L
Sbjct: 61 QMQCKVYDSLLALPQDLQAARALCVIALLVALFGLLVYLAGAKCTTCVEEKDS-KARLVL 119
Query: 120 TSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGW 179
TSGI+F++SG+ + V A+ ++ +F+ +V Q R GA+L++GW
Sbjct: 120 TSGIVFVISGVLTLIPVCWTAHAIIRDFY----------NPLVAEAQKR-ELGASLYLGW 168
Query: 180 VAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGF 225
A GL L+GG ++C C + ++ Y S +++ P +
Sbjct: 169 AASGLLLLGGGLLCCTCPSGGSQGPSHYMARYSTSAPAISRGPSEY 214
>gi|4502875 claudin 3 [Homo sapiens]
Length = 220
Score = 122 bits (305), Expect = 4e-28
Identities = 76/229 (33%), Positives = 122/229 (53%), Gaps = 20/229 (8%)
Query: 10 GFVVSLIGIAGIIAATCMDQWSTQDLY-NNPVTAVFNYQGLWRSCVRESSGFTECRGYFT 68
G ++++G G I + W +N +T+ ++GLW +CV +S+G +C+ Y +
Sbjct: 9 GTALAVLGWLGTIVCCALPMWRVSAFIGSNIITSQNIWEGLWMNCVVQSTGQMQCKVYDS 68
Query: 69 LLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVS 128
LL LP LQA RAL++V I+L A GLLV++ +C +D+AKA +T+ +G++F+++
Sbjct: 69 LLALPQDLQAARALIVVAILLAAFGLLVALVGAQCTNC-VQDDTAKAKITIVAGVLFLLA 127
Query: 129 GLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIG 188
L + VS AN ++ +F+ +V Q R GA L+VGW A L L+G
Sbjct: 128 ALLTLVPVSWSANTIIRDFY----------NPVVPEAQKR-EMGAGLYVGWAAAALQLLG 176
Query: 189 GVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKN 237
G ++C +C P E Y A S A + G AS G G + K+
Sbjct: 177 GALLCCSC---PPREKKYTATKVVYS----APRSTGPGASLGTGYDRKD 218
>gi|4502877 claudin 4 [Homo sapiens]
Length = 209
Score = 120 bits (300), Expect = 2e-27
Identities = 73/221 (33%), Positives = 123/221 (55%), Gaps = 15/221 (6%)
Query: 1 MAVTACQGLGFVVSLIGIAGIIAATCMDQWS-TQDLYNNPVTAVFNYQGLWRSCVRESSG 59
MA Q +G ++++G ++ + W T + +N VT+ ++GLW +CV +S+G
Sbjct: 1 MASMGLQVMGIALAVLGWLAVMLCCALPMWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTG 60
Query: 60 FTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTL 119
+C+ Y +LL LP LQA RAL+I+ I++ A+G+L+S+ KC ++SAKA +
Sbjct: 61 QMQCKVYDSLLALPQDLQAARALVIISIIVAALGVLLSVVGGKCTNC-LEDESAKAKTMI 119
Query: 120 TSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGW 179
+G++F+++GL I VS A+ ++ +F+ +V + Q R GA+L+VGW
Sbjct: 120 VAGVVFLLAGLMVIVPVSWTAHNIIQDFY----------NPLVASGQKR-EMGASLYVGW 168
Query: 180 VAGGLTLIGGVMMCIAC--RGLAPEETNYKAVSYHASGHSV 218
A GL L+GG ++C C R P Y A A+ + V
Sbjct: 169 AASGLLLLGGGLLCCNCPPRTDKPYSAKYSAARSAAASNYV 209
>gi|7656981 claudin 15 [Homo sapiens]
Length = 228
Score = 117 bits (294), Expect = 8e-27
Identities = 61/192 (31%), Positives = 104/192 (54%), Gaps = 12/192 (6%)
Query: 5 ACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECR 64
A + GF ++ +G+ + W ++ N +T ++ LW SC +S G C
Sbjct: 4 AVETFGFFMATVGLLMLGVTLPNSYWRVSTVHGNVITTNTIFENLWFSCATDSLGVYNCW 63
Query: 65 GYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIM 124
+ ++L L +QA RALMI I+LG +GLL+ I L+C IG +E S KA + T+G +
Sbjct: 64 EFPSMLALSGYIQACRALMITAILLGFLGLLLGIAGLRCTNIGGLELSRKAKLAATAGAL 123
Query: 125 FIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGL 184
I++G+C + +S +A + +F+ +Y G T+Y G AL++GW A +
Sbjct: 124 HILAGICGMVAISWYAFNITRDFF---DPLYPG---------TKYELGPALYLGWSASLI 171
Query: 185 TLIGGVMMCIAC 196
+++GG+ +C AC
Sbjct: 172 SILGGLCLCSAC 183
>gi|195947374 claudin 5 [Homo sapiens]
Length = 303
Score = 115 bits (289), Expect = 3e-26
Identities = 65/194 (33%), Positives = 106/194 (54%), Gaps = 13/194 (6%)
Query: 1 MAVTACQGLGFVVSLIGIAGIIAATCMDQWS-TQDLYNNPVTAVFNYQGLWRSCVRESSG 59
M A + LG V+ L+G G+I A + W T L +N VTA ++GLW SCV +S+G
Sbjct: 86 MGSAALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTG 145
Query: 60 FTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTL 119
+C+ Y ++L L +QA RAL + ++L + L V++ +C + AKA + L
Sbjct: 146 HMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVA-PGPAKARVAL 204
Query: 120 TSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGW 179
T G++++ GL A+ + FAN++V F+ + V +Y GAAL++GW
Sbjct: 205 TGGVLYLFCGLLALVPLCWFANIVVREFYDPSV-----------PVSQKYELGAALYIGW 253
Query: 180 VAGGLTLIGGVMMC 193
A L ++GG ++C
Sbjct: 254 AATALLMVGGCLLC 267
>gi|195947372 claudin 5 [Homo sapiens]
Length = 303
Score = 115 bits (289), Expect = 3e-26
Identities = 65/194 (33%), Positives = 106/194 (54%), Gaps = 13/194 (6%)
Query: 1 MAVTACQGLGFVVSLIGIAGIIAATCMDQWS-TQDLYNNPVTAVFNYQGLWRSCVRESSG 59
M A + LG V+ L+G G+I A + W T L +N VTA ++GLW SCV +S+G
Sbjct: 86 MGSAALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTG 145
Query: 60 FTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTL 119
+C+ Y ++L L +QA RAL + ++L + L V++ +C + AKA + L
Sbjct: 146 HMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVA-PGPAKARVAL 204
Query: 120 TSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGW 179
T G++++ GL A+ + FAN++V F+ + V +Y GAAL++GW
Sbjct: 205 TGGVLYLFCGLLALVPLCWFANIVVREFYDPSV-----------PVSQKYELGAALYIGW 253
Query: 180 VAGGLTLIGGVMMC 193
A L ++GG ++C
Sbjct: 254 AATALLMVGGCLLC 267
>gi|231569235 claudin 10 isoform a_i1 [Homo sapiens]
Length = 207
Score = 114 bits (285), Expect = 9e-26
Identities = 77/241 (31%), Positives = 114/241 (47%), Gaps = 56/241 (23%)
Query: 17 GIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECRGYFTLLGLPAML 76
G ++AAT ++W ++ +TA + YQGLW +C GY +
Sbjct: 15 GFGALVAATTSNEWKVTTRASSVITATWVYQGLWMNCA----------GY---------I 55
Query: 77 QAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGV 136
QA R LMI + LG G + ++F +KC ++G D AKA + +GI+FI+SGLC++ G
Sbjct: 56 QACRGLMIAAVSLGFFGSIFALFGMKCTKVGG-SDKAKAKIACLAGIVFILSGLCSMTGC 114
Query: 137 SVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIAC 196
S++AN + T F+ V+ +Y GAALF+GW L +IGGV+ C +
Sbjct: 115 SLYANKITTEFFDPL------------FVEQKYELGAALFIGWAGASLCIIGGVIFCFSI 162
Query: 197 RGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPS 256
N K Y +G A++ S TK Y GG ED + PS
Sbjct: 163 ------SDNNKTPRYTYNG-----------ATSVMSSRTK----YHGG---EDFKTTNPS 198
Query: 257 K 257
K
Sbjct: 199 K 199
>gi|40788011 claudin 8 [Homo sapiens]
Length = 225
Score = 114 bits (284), Expect = 1e-25
Identities = 60/194 (30%), Positives = 101/194 (52%), Gaps = 12/194 (6%)
Query: 1 MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNY-QGLWRSCVRESSG 59
MA A + G + +G+ G +A T M QW N + N+ +GLW +CVR+++
Sbjct: 1 MATHALEIAGLFLGGVGMVGTVAVTVMPQWRVSAFIENNIVVFENFWEGLWMNCVRQANI 60
Query: 60 FTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTL 119
+C+ Y +LL L LQA R LM V+ + +++I +KC R + KA++ L
Sbjct: 61 RMQCKIYDSLLALSPDLQAARGLMCAASVMSFLAFMMAILGMKCTRCTGDNEKVKAHILL 120
Query: 120 TSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGW 179
T+GI+FI++G+ + VS AN ++ +F+ S N V + G AL++GW
Sbjct: 121 TAGIIFIITGMVVLIPVSWVANAIIRDFYNSIVN-----------VAQKRELGEALYLGW 169
Query: 180 VAGGLTLIGGVMMC 193
+ ++GG + C
Sbjct: 170 TTALVLIVGGALFC 183
>gi|169166402 PREDICTED: claudin-24-like [Homo sapiens]
Length = 220
Score = 112 bits (281), Expect = 2e-25
Identities = 73/209 (34%), Positives = 106/209 (50%), Gaps = 15/209 (7%)
Query: 4 TACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNY-QGLWRSCVRESSGFTE 62
TA Q +G ++SL+G I T + W +L N + N+ GLW++CV + +
Sbjct: 7 TAMQSVGLLLSLLGWILSIITTYLPHWKNLNLDLNEME---NWTMGLWQTCVIQEEVGMQ 63
Query: 63 CRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSG 122
C+ + + L LPA L+ R LM + LG +GLLVS F L C+RIG + K + + G
Sbjct: 64 CKDFDSFLALPAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGG 123
Query: 123 IMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAG 182
I+ SG+ A+ VS A+ V FW V R+ FG ALF+GW AG
Sbjct: 124 ILSWASGITALVPVSWVAHKTVQEFWDEN----------VPDFVPRWEFGEALFLGWFAG 173
Query: 183 GLTLIGGVMM-CIACRGLAPEETNYKAVS 210
L+GG ++ C AC AP + AV+
Sbjct: 174 LSLLLGGCLLNCAACSSHAPLALGHYAVA 202
>gi|6912316 claudin 17 [Homo sapiens]
Length = 224
Score = 112 bits (281), Expect = 2e-25
Identities = 62/198 (31%), Positives = 105/198 (53%), Gaps = 14/198 (7%)
Query: 1 MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFN--YQGLWRSCVRESS 58
MA Q G V+ +G+ G +A T + QW + + VF ++GLW +C+R++
Sbjct: 1 MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNII-VFERLWEGLWMNCIRQAR 59
Query: 59 GFTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMT 118
+C+ Y +LL LP L+ RALM V + L I LL+ I +K ++ + AKA +
Sbjct: 60 VRLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLL 119
Query: 119 LTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVG 178
TSG++FI++G+ + VS AN+++ +F+ + + + GAALF+G
Sbjct: 120 GTSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIH-----------IGQKRELGAALFLG 168
Query: 179 WVAGGLTLIGGVMMCIAC 196
W + + IGG ++C C
Sbjct: 169 WASAAVLFIGGGLLCGFC 186
>gi|169167239 PREDICTED: claudin-24-like [Homo sapiens]
Length = 220
Score = 111 bits (277), Expect = 7e-25
Identities = 72/209 (34%), Positives = 105/209 (50%), Gaps = 15/209 (7%)
Query: 4 TACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNY-QGLWRSCVRESSGFTE 62
TA Q +G ++S +G I T + W +L N + N+ GLW++CV + +
Sbjct: 7 TAMQSVGLLLSFLGWILSIITTYLPHWKNLNLDLNEME---NWTMGLWQTCVIQEEVGMQ 63
Query: 63 CRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSG 122
C+ + + L LPA L+ R LM + LG +GLLVS F L C+RIG + K + + G
Sbjct: 64 CKDFDSFLALPAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGG 123
Query: 123 IMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAG 182
I+ SG+ A+ VS A+ V FW V R+ FG ALF+GW AG
Sbjct: 124 ILSWASGITALVPVSWVAHKTVQEFWDEN----------VPDFVPRWEFGEALFLGWFAG 173
Query: 183 GLTLIGGVMM-CIACRGLAPEETNYKAVS 210
L+GG ++ C AC AP + AV+
Sbjct: 174 LSLLLGGCLLNCAACSSHAPLALGHYAVA 202
>gi|169166931 PREDICTED: claudin-24-like [Homo sapiens]
Length = 220
Score = 111 bits (277), Expect = 7e-25
Identities = 72/209 (34%), Positives = 105/209 (50%), Gaps = 15/209 (7%)
Query: 4 TACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNY-QGLWRSCVRESSGFTE 62
TA Q +G ++S +G I T + W +L N + N+ GLW++CV + +
Sbjct: 7 TAMQSVGLLLSFLGWILSIITTYLPHWKNLNLDLNEME---NWTMGLWQTCVIQEEVGMQ 63
Query: 63 CRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSG 122
C+ + + L LPA L+ R LM + LG +GLLVS F L C+RIG + K + + G
Sbjct: 64 CKDFDSFLALPAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGG 123
Query: 123 IMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAG 182
I+ SG+ A+ VS A+ V FW V R+ FG ALF+GW AG
Sbjct: 124 ILSWASGITALVPVSWVAHKTVQEFWDEN----------VPDFVPRWEFGEALFLGWFAG 173
Query: 183 GLTLIGGVMM-CIACRGLAPEETNYKAVS 210
L+GG ++ C AC AP + AV+
Sbjct: 174 LSLLLGGCLLNCAACSSHAPLALGHYAVA 202
>gi|11141861 claudin 9 [Homo sapiens]
Length = 217
Score = 110 bits (275), Expect = 1e-24
Identities = 60/197 (30%), Positives = 109/197 (55%), Gaps = 13/197 (6%)
Query: 1 MAVTACQGLGFVVSLIGIAGIIAATCMDQWS-TQDLYNNPVTAVFNYQGLWRSCVRESSG 59
MA T + LG ++++G G + + + W T + N+ V A ++GLW SCV +S+G
Sbjct: 1 MASTGLELLGMTLAVLGWLGTLVSCALPLWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTG 60
Query: 60 FTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTL 119
+C+ Y +LL LP LQA RAL ++ ++L +GLLV+I +C ++ AKA + L
Sbjct: 61 QMQCKVYDSLLALPQDLQAARALCVIALLLALLGLLVAITGAQCTTCVE-DEGAKARIVL 119
Query: 120 TSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGW 179
T+G++ +++G+ + V A+ ++ +F+ + + GA+L++GW
Sbjct: 120 TAGVILLLAGILVLIPVCWTAHAIIQDFY-----------NPLVAEALKRELGASLYLGW 168
Query: 180 VAGGLTLIGGVMMCIAC 196
A L ++GG ++C C
Sbjct: 169 AAAALLMLGGGLLCCTC 185
>gi|47716519 claudin 20 [Homo sapiens]
Length = 219
Score = 106 bits (265), Expect = 2e-23
Identities = 56/203 (27%), Positives = 102/203 (50%), Gaps = 13/203 (6%)
Query: 1 MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQ-DLYNNPVTAVFNYQGLWRSCVRESSG 59
MA Q L F+++L G++G++ AT + W D+ +N +TA+ GLW C S+G
Sbjct: 1 MASAGLQLLAFILALSGVSGVLTATLLPNWKVNVDVDSNIITAIVQLHGLWMDCTWYSTG 60
Query: 60 FTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTL 119
C ++L LP +QA RA M++ VL A+G+ S +KC R+G + K++ +
Sbjct: 61 MFSCALKHSILSLPIHVQAARATMVLACVLSALGICTSTVGMKCTRLGG-DRETKSHASF 119
Query: 120 TSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGW 179
G+ F+ +G+ ++ + ++ NF T ++ G A+++G+
Sbjct: 120 AGGVCFMSAGISSLISTVWYTKEIIANFLDLTV-----------PESNKHEPGGAIYIGF 168
Query: 180 VAGGLTLIGGVMMCIACRGLAPE 202
++ L I G++ C +C PE
Sbjct: 169 ISAMLLFISGMIFCTSCIKRNPE 191
>gi|162417973 claudin 22 [Homo sapiens]
Length = 220
Score = 105 bits (262), Expect = 4e-23
Identities = 71/215 (33%), Positives = 103/215 (47%), Gaps = 15/215 (6%)
Query: 4 TACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNY-QGLWRSCVRESSGFTE 62
T Q G +SL+G + W +L N + N+ GLW++CV + +
Sbjct: 7 TVAQLAGVSLSLLGWVLSCLTNYLPHWKNLNLDLNEME---NWTMGLWQTCVIQEEVGMQ 63
Query: 63 CRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSG 122
C+ + + L LPA L+ R LM + LG +GLLVS F L C+RIG + K + + G
Sbjct: 64 CKDFDSFLALPAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGG 123
Query: 123 IMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAG 182
I+ SG+ A+ VS A+ V FW V R+ FG ALF+GW AG
Sbjct: 124 ILSWASGVTALVPVSWVAHKTVQEFWDEN----------VPDFVPRWEFGEALFLGWFAG 173
Query: 183 GLTLIGGVMM-CIACRGLAPEETNYKAVSYHASGH 216
L+GG ++ C AC AP + + AV+ H
Sbjct: 174 LSLLLGGCLLHCAACSSHAPLASGHYAVAQTQDHH 208
>gi|9966781 claudin 2 [Homo sapiens]
Length = 230
Score = 104 bits (260), Expect = 7e-23
Identities = 59/224 (26%), Positives = 108/224 (48%), Gaps = 13/224 (5%)
Query: 1 MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYN-NPVTAVFNYQGLWRSCVRESSG 59
MA Q +G+++ L+G+ G + A + W T + VTAV +GLW C S+G
Sbjct: 1 MASLGLQLVGYILGLLGLLGTLVAMLLPSWKTSSYVGASIVTAVGFSKGLWMECATHSTG 60
Query: 60 FTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTL 119
T+C Y TLLGLPA +QA +A+M+ + ++ ++S+ ++C + E AK + +
Sbjct: 61 ITQCDIYSTLLGLPADIQAAQAMMVTSSAISSLACIISVVGMRC-TVFCQESRAKDRVAV 119
Query: 120 TSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGW 179
G+ FI+ GL V+ + ++ +F+ + ++ G AL++G
Sbjct: 120 AGGVFFILGGLLGFIPVAWNLHGILRDFY-----------SPLVPDSMKFEIGEALYLGI 168
Query: 180 VAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPG 223
++ +LI G+++C +C Y A + +PG
Sbjct: 169 ISSLFSLIAGIILCFSCSSQRNRSNYYDAYQAQPLATRSSPRPG 212
>gi|10938016 claudin 11 [Homo sapiens]
Length = 207
Score = 95.1 bits (235), Expect = 5e-20
Identities = 68/221 (30%), Positives = 97/221 (43%), Gaps = 28/221 (12%)
Query: 1 MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNY---QGLWRSCVRES 57
M T Q +GFV S +G G+I T + W Y P + +GLW CV +
Sbjct: 1 MVATCLQVVGFVTSFVGWIGVIVTTSTNDWVVTCGYTIPTCRKLDELGSKGLWADCVM-A 59
Query: 58 SGFTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANM 117
+G C+ +L LP +QA RALMI VLG +L+ + L CIR+G AK
Sbjct: 60 TGLYHCKPLVDILILPGYVQACRALMIAASVLGLPAILLLLTVLPCIRMGQEPGVAKYRR 119
Query: 118 TLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFV 177
+G++ I+ LCA LV W T +FG +L+
Sbjct: 120 AQLAGVLLILLALCA----------LVATIWFPVC---------AHRETTIVSFGYSLYA 160
Query: 178 GWVAGGLTLIGG-VMMCIACRGLAPEETNYKAVSYHASGHS 217
GW+ L L+GG V++C A A E + Y+ +G S
Sbjct: 161 GWIGAVLCLVGGCVILCCAGDAQAFGENRF----YYTAGSS 197
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.136 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,958,444
Number of Sequences: 37866
Number of extensions: 352566
Number of successful extensions: 1203
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 29
Number of HSP's that attempted gapping in prelim test: 1089
Number of HSP's gapped (non-prelim): 69
length of query: 261
length of database: 18,247,518
effective HSP length: 100
effective length of query: 161
effective length of database: 14,460,918
effective search space: 2328207798
effective search space used: 2328207798
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.