Search of human proteins with 5032099

Search of human proteins with 5032099

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5032099 smoothened [Homo sapiens]
         (787 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5032099 smoothened [Homo sapiens]                                 1631   0.0  
gi|4503825 frizzled 1 [Homo sapiens]                                  193   6e-49
gi|27894385 frizzled 5 precursor [Homo sapiens]                       183   6e-46
gi|4503833 frizzled 7 [Homo sapiens]                                  182   1e-45
gi|4503827 frizzled 2 [Homo sapiens]                                  174   3e-43
gi|22547161 frizzled 4 [Homo sapiens]                                 172   1e-42
gi|8393378 frizzled 3 [Homo sapiens]                                  167   3e-41
gi|6005762 frizzled 10 [Homo sapiens]                                 163   5e-40
gi|34734079 frizzled 6 [Homo sapiens]                                 163   7e-40
gi|13994190 frizzled 8 [Homo sapiens]                                 159   9e-39
gi|4503835 frizzled 9 [Homo sapiens]                                  154   4e-37
gi|56117838 secreted frizzled-related protein 1 [Homo sapiens]         49   2e-05
gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens]      48   3e-05
gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens]                48   4e-05
gi|188528609 secreted frizzled-related protein 5 [Homo sapiens]        44   4e-04
gi|170784838 secreted frizzled-related  protein 4 [Homo sapiens]       43   0.001
gi|38455388 frizzled-related protein [Homo sapiens]                    41   0.005
gi|13899255 membrane frizzled-related protein [Homo sapiens]           41   0.005
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa...    41   0.005
gi|29244926 corin [Homo sapiens]                                       40   0.008
gi|166706868 synaptopodin 2-like isoform a [Homo sapiens]              40   0.011
gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]         39   0.019
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    39   0.024
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    38   0.032
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    38   0.032
gi|145386517 phostensin [Homo sapiens]                                 38   0.032
gi|199559805 phostensin [Homo sapiens]                                 38   0.032
gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens]             38   0.042
gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapi...    38   0.042
gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sap...    38   0.042

>gi|5032099 smoothened [Homo sapiens]
          Length = 787

 Score = 1631 bits (4223), Expect = 0.0
 Identities = 787/787 (100%), Positives = 787/787 (100%)

Query: 1   MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPP 60
           MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPP
Sbjct: 1   MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPP 60

Query: 61  LSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWA 120
           LSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWA
Sbjct: 61  LSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWA 120

Query: 121 VIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTN 180
           VIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTN
Sbjct: 121 VIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTN 180

Query: 181 EVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAV 240
           EVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAV
Sbjct: 181 EVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAV 240

Query: 241 TGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT 300
           TGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT
Sbjct: 241 TGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT 300

Query: 301 MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF 360
           MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF
Sbjct: 301 MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF 360

Query: 361 HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI 420
           HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI
Sbjct: 361 HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI 420

Query: 421 RGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEW 480
           RGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEW
Sbjct: 421 RGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEW 480

Query: 481 ERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKA 540
           ERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKA
Sbjct: 481 ERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKA 540

Query: 541 TLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPV 600
           TLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPV
Sbjct: 541 TLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPV 600

Query: 601 AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAE 660
           AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAE
Sbjct: 601 AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAE 660

Query: 661 ISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWG 720
           ISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWG
Sbjct: 661 ISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWG 720

Query: 721 AGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTEL 780
           AGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTEL
Sbjct: 721 AGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTEL 780

Query: 781 MDADSDF 787
           MDADSDF
Sbjct: 781 MDADSDF 787


>gi|4503825 frizzled 1 [Homo sapiens]
          Length = 647

 Score =  193 bits (490), Expect = 6e-49
 Identities = 168/629 (26%), Positives = 266/629 (42%), Gaps = 101/629 (16%)

Query: 5   RPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPPLSHC 64
           RP   P      LLLLL L +          A G GP    G  ++      PPPP    
Sbjct: 43  RPPVDPRRLARQLLLLLWLLEAPLLLGVRAQAAGQGPGQGPGPGQQP-----PPPPQQQQ 97

Query: 65  ---------GRAAP----CEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSG 111
                    G + P    C+P+   +C            LL     +QE+A  ++  +  
Sbjct: 98  SGQQYNGERGISVPDHGYCQPISIPLCTDIAYNQTIMPNLLG--HTNQEDAGLEVHQFYP 155

Query: 112 LRNAPRCWAVIQPLLCAVYMPKCENDRVELPS-RTLCQATRGPCAIVERERG--WPDFLR 168
           L    +C A ++  LC++Y P C      LP  R+LC+  R  C  +  + G  WPD L+
Sbjct: 156 LVKV-QCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLK 214

Query: 169 C-----------------------TPDRFPEGCTNEVQNIKFNSSG-------------- 191
           C                       TP   PE  T+  Q+      G              
Sbjct: 215 CEKFPVHGAGELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKF 274

Query: 192 QCEVPLVRTDNPKSWYEDVEGCGIQCQNP------LFTEAEHQDMHSYIAAFGAVTGLCT 245
            C   L         +   + CG  C+         F   E +   ++I  +  +    T
Sbjct: 275 SCPRALKVPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCAST 334

Query: 246 LFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCR----ADGTM 301
           LFT+ T++ D R  + YP   + +++ C+   ++ ++A F+   R  +VC      DG  
Sbjct: 335 LFTVLTYLVDMRRFS-YPERPIIFLSGCYTAVAVAYIAGFLLEDR--VVCNDKFAEDGAR 391

Query: 302 RLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTY--QPLSGKTSY 359
            + + T  E   C I+F+++Y+  MA  +W+V+L+  W   F A G  +  + +   + Y
Sbjct: 392 TVAQGTKKE--GCTILFMMLYFFSMASSIWWVILSLTW---FLAAGMKWGHEAIEANSQY 446

Query: 360 FHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFL 419
           FHL  W++P + T+ ILA+ QVDGD +SG+CFVG  N     GFVLAP+ + L +G  FL
Sbjct: 447 FHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFL 506

Query: 420 IRGVMTLFSIKS--NHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQ 477
           + G ++LF I++   H G  +E    K+ + M+R+G+F  L      I  +C+FY+   +
Sbjct: 507 LAGFVSLFRIRTIMKHDGTKTE----KLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFR 562

Query: 478 AEWERSF-----RDYVLCQANVTI--GLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGI 530
            +WERS+     + Y +   ++    G P   P+        P   V  I        GI
Sbjct: 563 DQWERSWVAQSCKSYAIPCPHLQAGGGAPPHPPM-------SPDFTVFMIKYLMTLIVGI 615

Query: 531 AMSTWVWTKATLLIWRRTWCRLTGQSDDE 559
               W+W+  TL  WR+ + RLT     E
Sbjct: 616 TSGFWIWSGKTLNSWRKFYTRLTNSKQGE 644


>gi|27894385 frizzled 5 precursor [Homo sapiens]
          Length = 585

 Score =  183 bits (464), Expect = 6e-46
 Identities = 151/552 (27%), Positives = 251/552 (45%), Gaps = 84/552 (15%)

Query: 66  RAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPL 125
           +A  C+ +   +C G  + Y  T      + D+Q+EA  ++  +  L    +C   ++  
Sbjct: 29  KAPVCQEITVPMCRG--IGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEI-QCSPDLRFF 85

Query: 126 LCAVYMPKCEND--RVELPSRTLCQATRGPCAIVERERG--WPDFLRCTPDRFPE-GCTN 180
           LC++Y P C  D  +   P R++C+  +  C+ + R+ G  WP+ + C  DR P  G   
Sbjct: 86  LCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSC--DRLPVLGRDA 143

Query: 181 EVQNIKFN--------------------------SSGQCE-------------VPLVRTD 201
           EV  + +N                          S G+C              VP+++  
Sbjct: 144 EVLCMDYNRSEATTAPPRPFPAKPTLPGPPGAPASGGECPAGGPFVCKCREPFVPILKES 203

Query: 202 NP---KSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRN 258
           +P   K     V  C + C  P F+  E      +I  +  +  + T  T+ATF+ D   
Sbjct: 204 HPLYNKVRTGQVPNCAVPCYQPSFSADERTFATFWIGLWSVLCFISTSTTVATFLIDMER 263

Query: 259 SNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRLGEPTSNETLSCVIIF 318
             RYP   + +++AC+   S+G+L + + G    + C  +    +   T+   L C I+F
Sbjct: 264 F-RYPERPIIFLSACYLCVSLGFLVRLVVG-HASVACSREHN-HIHYETTGPAL-CTIVF 319

Query: 319 VIVYYALMAGVVWFVVLTYAWHTSFKALGTTY--QPLSGKTSYFHLLTWSLPFVLTVAIL 376
           ++VY+  MA  +W+V+L+  W   F A G  +  + ++G   YFHL  W +P V ++  L
Sbjct: 320 LLVYFFGMASSIWWVILSLTW---FLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITAL 376

Query: 377 AVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKS--NHP 434
           A++ VDGD V+GIC+VG +N     GFVL P+ L L+VG  FL+ G ++LF I+S     
Sbjct: 377 ALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQG 436

Query: 435 GLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANV 494
           G  ++    K+ + M+R+GIF  L      I  +C+ Y+   +  WE +    + C    
Sbjct: 437 GTKTD----KLEKLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEAA----LTCACP- 487

Query: 495 TIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTG 554
             G  T QP      + +P   V  +  F     GI    W+W+  T+  WR    R T 
Sbjct: 488 --GHDTGQP------RAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWR----RFTS 535

Query: 555 QSDDEPKRIKKS 566
           +    P+R  KS
Sbjct: 536 RCCCRPRRGHKS 547


>gi|4503833 frizzled 7 [Homo sapiens]
          Length = 574

 Score =  182 bits (461), Expect = 1e-45
 Identities = 142/498 (28%), Positives = 224/498 (44%), Gaps = 74/498 (14%)

Query: 117 RCWAVIQPLLCAVYMPKCEN-DRVELPSRTLCQATRGPCAIVERERG--WPDFLRCTPDR 173
           +C   ++  LC++Y P C   D+   P R+LC+  R  C  +  + G  WP+ LRC  + 
Sbjct: 93  QCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRC--EN 150

Query: 174 FPEGCTNEV---QNIKFNSSGQCEVPLVRTDNP----------KSWYEDVEG-------- 212
           FP     E+   QN    S G    P      P               D  G        
Sbjct: 151 FPVHGAGEICVGQNTSDGSGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGRPAFPFSC 210

Query: 213 -------------------CGIQCQ----NPL--FTEAEHQDMHSYIAAFGAVTGLCTLF 247
                              CG  C+    N L  F E E +    ++  +  +    TLF
Sbjct: 211 PRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLF 270

Query: 248 TLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRA--DGTMRLGE 305
           T+ T++ D R  + YP   + +++ C+F+ ++  +A F+   R   V R   DG   + +
Sbjct: 271 TVLTYLVDMRRFS-YPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSDDGYRTVAQ 329

Query: 306 PTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTY--QPLSGKTSYFHLL 363
            T  E   C I+F+++Y+  MA  +W+V+L+  W   F A G  +  + +   + YFHL 
Sbjct: 330 GTKKE--GCTILFMVLYFFGMASSIWWVILSLTW---FLAAGMKWGHEAIEANSQYFHLA 384

Query: 364 TWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGV 423
            W++P V T+ ILA+ QVDGD +SG+C+VG  +     GFVLAP+ + L +G  FL+ G 
Sbjct: 385 AWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGF 444

Query: 424 MTLFSIKS--NHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWE 481
           ++LF I++   H G  +E    K+ + M+R+G+F  L      I  +C+FY+   +  WE
Sbjct: 445 VSLFRIRTIMKHDGTKTE----KLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWE 500

Query: 482 RSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKAT 541
           R++    L Q   +  +P     P       P   V  I        GI    W+W+  T
Sbjct: 501 RTW----LLQTCKSYAVPCP---PGHFPPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKT 553

Query: 542 LLIWRRTWCRLTGQSDDE 559
           L  WRR + RL+  S  E
Sbjct: 554 LQSWRRFYHRLSHSSKGE 571


>gi|4503827 frizzled 2 [Homo sapiens]
          Length = 565

 Score =  174 bits (441), Expect = 3e-43
 Identities = 130/502 (25%), Positives = 222/502 (44%), Gaps = 81/502 (16%)

Query: 117 RCWAVIQPLLCAVYMPKCEN-DRVELPSRTLCQATRGPCAIVERERG--WPDFLRCTPDR 173
           +C   ++  LC++Y P C   ++   P R++C+  R  C  +  + G  WP+ LRC  + 
Sbjct: 83  QCSPELRFFLCSMYAPVCTVLEQAIPPCRSICERARQGCEALMNKFGFQWPERLRC--EH 140

Query: 174 FPEGCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEG--------------------- 212
           FP     ++  +  N S      L+ T  P        G                     
Sbjct: 141 FPRHGAEQIC-VGQNHSEDGAPALLTTAPPPGLQPGAGGTPGGPGGGGAPPRYATLEHPF 199

Query: 213 ---------------------CGIQCQ------NPLFTEAEHQDMHSYIAAFGAVTGLCT 245
                                C   C+      +  F++ E +    +I  +  +    T
Sbjct: 200 HCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMFFSQEETRFARLWILTWSVLCCAST 259

Query: 246 LFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRA----DGTM 301
            FT+ T++ D +   RYP   + +++ C+ + S+ ++A F+   +  +VC      DG  
Sbjct: 260 FFTVTTYLVDMQRF-RYPERPIIFLSGCYTMVSVAYIAGFV--LQERVVCNERFSEDGYR 316

Query: 302 RLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTY--QPLSGKTSY 359
            + + T  E   C I+F+++Y+  MA  +W+V+L+  W   F A G  +  + +   + Y
Sbjct: 317 TVVQGTKKE--GCTILFMMLYFFSMASSIWWVILSLTW---FLAAGMKWGHEAIEANSQY 371

Query: 360 FHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFL 419
           FHL  W++P V T+ ILA+ Q+DGD +SG+CFVG  +     GFVLAP+ + L +G  FL
Sbjct: 372 FHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPLFVYLFIGTSFL 431

Query: 420 IRGVMTLFSIKS--NHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQ 477
           + G ++LF I++   H G  +E    K+   M+R+G+F  L      I  +C+FY+   +
Sbjct: 432 LAGFVSLFRIRTIMKHDGTKTE----KLERLMVRIGVFSVLYTVPATIVIACYFYEQAFR 487

Query: 478 AEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVW 537
             WERS+    + Q   ++ +P          +  P   V  I        GI    W+W
Sbjct: 488 EHWERSW----VSQHCKSLAIPCPAHYTP---RMSPDFTVYMIKYLMTLIVGITSGFWIW 540

Query: 538 TKATLLIWRRTWCRLTGQSDDE 559
           +  TL  WR+ + RLT     E
Sbjct: 541 SGKTLHSWRKFYTRLTNSRHGE 562


>gi|22547161 frizzled 4 [Homo sapiens]
          Length = 537

 Score =  172 bits (435), Expect = 1e-42
 Identities = 133/523 (25%), Positives = 240/523 (45%), Gaps = 71/523 (13%)

Query: 70  CEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAV 129
           C+P+R ++C    L Y  T        + Q +A  +L  ++ L     C + +Q  LC+V
Sbjct: 45  CDPIRISMCQN--LGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYG-CSSQLQFFLCSV 101

Query: 130 YMPKCENDRVELPSRT---LCQATRGPCAIVERERG--WPDFLRCTPDRFPEGCTNEVQN 184
           Y+P C  +++ +P      +C + +  C  V +E G  WP+ L C+  +FP    N+  +
Sbjct: 102 YVPMC-TEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCS--KFPP--QNDHNH 156

Query: 185 IKFNSSGQCEVPL--------------VRTDNPKS-WYEDVEGCGIQC--QNPLFTEAEH 227
           +     G  EVPL              V T++ +  W +    C ++C     L++ +  
Sbjct: 157 MCMEGPGDEEVPLPHKTPIQPGEECHSVGTNSDQYIWVKRSLNCVLKCGYDAGLYSRSAK 216

Query: 228 QDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMD 287
           +    ++A + ++  + T FT+ TF+ D    + YP   + +++ C+ + SI ++ +   
Sbjct: 217 EFTDIWMAVWASLCFISTAFTVLTFLIDSSRFS-YPERPIIFLSMCYNIYSIAYIVRLTV 275

Query: 288 GARREIVC---RADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFK 344
           G R  I C    A   + + E   N    C IIF+++Y+  MA  +W+V+LT  W  +  
Sbjct: 276 G-RERISCDFEEAAEPVLIQEGLKNT--GCAIIFLLMYFFGMASSIWWVILTLTWFLA-A 331

Query: 345 ALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFV 404
            L   ++ +   +SYFH+  W++P V T+ IL +  VD D ++G+C+VG +N     GFV
Sbjct: 332 GLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFV 391

Query: 405 LAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVL 464
           +AP+   L++G  F+  G++ LF I+SN           K+   M+++G+F  L      
Sbjct: 392 VAPLFTYLVIGTLFIAAGLVALFKIRSNLQ--KDGTKTDKLERLMVKIGVFSVLYTVPAT 449

Query: 465 ITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFA 524
              +C+FY+  N A +  S  D                           ++ VE + +F 
Sbjct: 450 CVIACYFYEISNWALFRYSADD--------------------------SNMAVEMLKIFM 483

Query: 525 MFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKRIKKSK 567
               GI    W+W+  TL  W++   RL         ++K+ K
Sbjct: 484 SLLVGITSGMWIWSAKTLHTWQKCSNRLVNSG-----KVKREK 521


>gi|8393378 frizzled 3 [Homo sapiens]
          Length = 666

 Score =  167 bits (423), Expect = 3e-41
 Identities = 134/504 (26%), Positives = 222/504 (44%), Gaps = 52/504 (10%)

Query: 70  CEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAV 129
           CEP+   +C    LPY  T      +   Q+ A   +  +  + N   C    +P LCA+
Sbjct: 28  CEPITLRMCQD--LPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLD-CSRDFRPFLCAL 84

Query: 130 YMPKC-ENDRVELPSRTLCQATRGPCAIVERERG--WPDFLRCTPDRFPEGCTNEVQNIK 186
           Y P C E  RV LP R LCQ     C+ +    G  WP+ + C+  RFP+      + + 
Sbjct: 85  YAPICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECS--RFPDCDEPYPRLVD 142

Query: 187 FNSSGQCE--VPLVRTDNPKSW--------------YEDVEGCGIQCQNPLFTEAEHQDM 230
            N +G+     P+    +   W              +  V  C   C N  F   E    
Sbjct: 143 LNLAGEPTEGAPVAVQRDYGFWCPRELKIDPDLGYSFLHVRDCSPPCPNMYFRREELSFA 202

Query: 231 HSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGAR 290
             +I     +    TLFT  TF+ D     RYP   + +   C+ + S+ +   F+   R
Sbjct: 203 RYFIGLISIICLSATLFTFLTFLIDVTRF-RYPERPIIFYAVCYMMVSLIFFIGFLLEDR 261

Query: 291 REIVCRADGTMRLGEPT---SNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALG 347
             + C A    +    T    +   +C ++F+I+Y+  MAG VW+V+LT  W  +     
Sbjct: 262 --VACNASIPAQYKASTVTQGSHNKACTMLFMILYFFTMAGSVWWVILTITWFLAAVPKW 319

Query: 348 TTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAP 407
            + + +  K   FH   W +P  LT+ +LA+ +++GD++SG+CFVG  +      FVLAP
Sbjct: 320 GS-EAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAP 378

Query: 408 IGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITF 467
           + L ++VG   L+ G+++L  ++   P  L ++   K+ + M+R+G+F  L    +L+  
Sbjct: 379 LCLYVVVGVSLLLAGIISLNRVRIEIP--LEKENQDKLVKFMIRIGVFSILYLVPLLVVI 436

Query: 468 SCHFYDFFNQAEWERSF-----RDY-VLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKIN 521
            C+FY+   +  WE ++     R+Y + C   VT               +RP L++  + 
Sbjct: 437 GCYFYEQAYRGIWETTWIQERCREYHIPCPYQVT-------------QMSRPDLILFLMK 483

Query: 522 LFAMFGTGIAMSTWVWTKATLLIW 545
                  GI    WV +K T   W
Sbjct: 484 YLMALIVGIPSVFWVGSKKTCFEW 507


>gi|6005762 frizzled 10 [Homo sapiens]
          Length = 581

 Score =  163 bits (413), Expect = 5e-40
 Identities = 139/544 (25%), Positives = 234/544 (43%), Gaps = 61/544 (11%)

Query: 70  CEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAV 129
           C+P+   +C    + Y  T        ++Q EA  +L  ++ L     C   ++  LC++
Sbjct: 34  CQPIEIPMCKD--IGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYG-CHGHLRFFLCSL 90

Query: 130 YMPKCENDRVELP---SRTLCQATRGPCAIVERERG--WPDFLRCT-------PDRFPEG 177
           Y P C  ++V  P    R +C+  R  C+ +  +    WPD L C        P+     
Sbjct: 91  YAPMC-TEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPNYLCME 149

Query: 178 CTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQ----CQNP------------- 220
             N   +     SG    PL R   P S  E     G      C NP             
Sbjct: 150 APNNGSDEPTRGSGLFP-PLFRPQRPHSAQEHPLKDGGPGRGGCDNPGKFHHVEKSASCA 208

Query: 221 ---------LFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVN 271
                     ++  + +    ++A +  +    + FT+ TF+ D     RYP   + +++
Sbjct: 209 PLCTPGVDVYWSREDKRFAVVWLAIWAVLCFFSSAFTVLTFLIDPARF-RYPERPIIFLS 267

Query: 272 ACFFVGSIGWLAQFMDGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVW 331
            C+ V S+G+L +   GA   I C  D           E+  C ++F+++YY  MA  +W
Sbjct: 268 MCYCVYSVGYLIRLFAGAE-SIACDRDSGQLYVIQEGLESTGCTLVFLVLYYFGMASSLW 326

Query: 332 FVVLTYAWHTSFKALGTTY--QPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGI 389
           +VVLT  W   F A G  +  + +   +SYFHL  W++P V T+ IL + +V GD ++G+
Sbjct: 327 WVVLTLTW---FLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGV 383

Query: 390 CFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETM 449
           C+VG  +     GFVL P+   L++G  F++ G + LF I+         +   K+ + M
Sbjct: 384 CYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVALFHIR--RVMKTGGENTDKLEKLM 441

Query: 450 LRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEI 509
           +R+G+F  L         +C+FY+  N   W+     +     N T  L       DC +
Sbjct: 442 VRIGLFSVLYTVPATCVIACYFYERLNMDYWKILAAQHKCKMNNQTKTL-------DCLM 494

Query: 510 -KNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWC-RLTGQSDDEPKRIKKSK 567
             + P++ +  + +F +   GI    W+WT  TL  W++    RL  +S  +P  +  S 
Sbjct: 495 AASIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQVCSRRLKKKSRRKPASVITSG 554

Query: 568 MIAK 571
            I K
Sbjct: 555 GIYK 558


>gi|34734079 frizzled 6 [Homo sapiens]
          Length = 706

 Score =  163 bits (412), Expect = 7e-40
 Identities = 125/453 (27%), Positives = 203/453 (44%), Gaps = 43/453 (9%)

Query: 118 CWAVIQPLLCAVYMPKC-ENDRVELPSRTLCQATRGPCAIVERERG--WPDFLRC----- 169
           C   I+  LC  ++P C E   V  P R LC+     C  +    G  WP+ L C     
Sbjct: 69  CSPNIETFLCKAFVPTCIEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQY 128

Query: 170 -------TPDRFPE--GCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNP 220
                  T D   E  G   + + ++ +    C   L  +      +  ++ C   C N 
Sbjct: 129 CDETVPVTFDPHTEFLGPQKKTEQVQRDIGFWCPRHLKTSGGQGYKFLGIDQCAPPCPNM 188

Query: 221 LFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIG 280
            F   E +   S+I          TLFT  TF+ D R   RYP   + Y + C+ + S+ 
Sbjct: 189 YFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRF-RYPERPIIYYSVCYSIVSLM 247

Query: 281 WLAQFMDGARREIVC-RADGTMRLGEPT--SNETLSCVIIFVIVYYALMAGVVWFVVLTY 337
           +   F+ G      C +AD  + LG+     ++  +C ++F+++Y+  MAG VW+V+LT 
Sbjct: 248 YFIGFLLGD--STACNKADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWWVILTI 305

Query: 338 AWHTSFKALGTTY--QPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYK 395
            W   F A G  +  + +  K  +FH + W  P  LTV +LA+ +V+GD++SG+CFVG  
Sbjct: 306 TW---FLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLY 362

Query: 396 NYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKS--NHPGLLSEKAASKINETMLRLG 453
           +      FVL P+ L + VG   L+ G+++L  ++    H G   E    K+ + M+R+G
Sbjct: 363 DLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQE----KLKKFMIRIG 418

Query: 454 IFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIP-DCEIKNR 512
           +F  L    ++    C+ Y+  N+  WE ++      Q ++        P P   + K R
Sbjct: 419 VFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHI--------PCPYQAKAKAR 470

Query: 513 PSLLVEKINLFAMFGTGIAMSTWVWTKATLLIW 545
           P L +  I        GI+   WV +K T   W
Sbjct: 471 PELALFMIKYLMTLIVGISAVFWVGSKKTCTEW 503


>gi|13994190 frizzled 8 [Homo sapiens]
          Length = 694

 Score =  159 bits (402), Expect = 9e-39
 Identities = 112/401 (27%), Positives = 182/401 (45%), Gaps = 65/401 (16%)

Query: 192 QCEVPLVRTDNPKS-WYEDVE-----GCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCT 245
           QC  P+V   + +   Y  V+      C + C NP F++ E      +I  +  +  + T
Sbjct: 233 QCRAPMVSVSSERHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVLCFVST 292

Query: 246 LFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCR--------- 296
             T++TF+ D     +YP   + +++AC+   S+G+L + + G   ++ C          
Sbjct: 293 FATVSTFLIDMERF-KYPERPIIFLSACYLFVSVGYLVRLVAG-HEKVACSGGAPGAGGA 350

Query: 297 ----------------ADGTMRLGE-------------PTSNETLSCVIIFVIVYYALMA 327
                           A G    GE              T+   L C ++F++VY+  MA
Sbjct: 351 GGAGGAAAGAGAAGAGAGGPGGRGEYEELGAVEQHVRYETTGPAL-CTVVFLLVYFFGMA 409

Query: 328 GVVWFVVLTYAWHTSFKALGTTY--QPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDS 385
             +W+V+L+  W   F A G  +  + ++G + YFHL  W +P V ++A+LA++ VDGD 
Sbjct: 410 SSIWWVILSLTW---FLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDP 466

Query: 386 VSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKI 445
           V+GIC+VG ++     GFVLAP+ + L +G  FL+ G ++LF I+S            K+
Sbjct: 467 VAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQDGPTKTHKL 526

Query: 446 NETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIP 505
            + M+RLG+F  L      +  +C FY+  N+  WE +      C       L   QP  
Sbjct: 527 EKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATHN----CPC-----LRDLQP-- 575

Query: 506 DCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWR 546
             +   RP   V  +  F     GI    WVW+  TL  WR
Sbjct: 576 --DQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWR 614



 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 33/111 (29%), Positives = 56/111 (50%), Gaps = 9/111 (8%)

Query: 70  CEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAV 129
           C+ +   +C G  + Y  T      + D+Q+EA  ++  +  L    +C   ++  LC++
Sbjct: 35  CQEITVPLCKG--IGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEI-QCSPDLKFFLCSM 91

Query: 130 YMPKCENDRVEL--PSRTLCQATRGPCAIVERERG--WPDFLRCTPDRFPE 176
           Y P C  D  +   P R++C+  +  CA + R+ G  WPD +RC  DR PE
Sbjct: 92  YTPICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRC--DRLPE 140


>gi|4503835 frizzled 9 [Homo sapiens]
          Length = 591

 Score =  154 bits (388), Expect = 4e-37
 Identities = 132/525 (25%), Positives = 221/525 (42%), Gaps = 67/525 (12%)

Query: 67  AAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLL 126
           AAPC+ +   +C G  + Y  T         SQ EA  +L  ++ L     C + ++  L
Sbjct: 36  AAPCQAVEIPMCRG--IGYNLTRMPNLLGHTSQGEAAAELAEFAPLVQYG-CHSHLRFFL 92

Query: 127 CAVYMPKCENDRVELP---SRTLCQATRGPCAIVERER--GWPDFLRCT----------- 170
           C++Y P C  D+V  P    R +C+  R  CA +  +   GWPD L C            
Sbjct: 93  CSLYAPMC-TDQVSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCARLPTRNDPHAL 151

Query: 171 ----PDRFPEGCTNEVQNIKF------------------NSSGQCEVPLVRTDNPKSWYE 208
               P+    G     + +                      SG CE P         + E
Sbjct: 152 CMEAPENATAGPAEPHKGLGMLPVAPRPARPPGDLGPGAGGSGTCENP-----EKFQYVE 206

Query: 209 DVEGCGIQCQN--PLFTEAEHQDMHS-YIAAFGAVTGLCTLFTLATFVADWRNSNRYPAV 265
               C  +C     +F     +D    ++A + A+    T FT+ TF+ +  +  +YP  
Sbjct: 207 KSRSCAPRCGPGVEVFWSRRDKDFALVWMAVWSALCFFSTAFTVLTFLLE-PHRFQYPER 265

Query: 266 ILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYAL 325
            + +++ C+ V S+ +L + + GA+  + C  +           E   C ++F+++YY  
Sbjct: 266 PIIFLSMCYNVYSLAFLIRAVAGAQ-SVACDQEAGALYVIQEGLENTGCTLVFLLLYYFG 324

Query: 326 MAGVVWFVVLTYAWHTSFKALGTTY--QPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDG 383
           MA  +W+VVLT  W   F A G  +  + +    SYFH+  W LP + T+ IL + +V G
Sbjct: 325 MASSLWWVVLTLTW---FLAAGKKWGHEAIEAHGSYFHMAAWGLPALKTIVILTLRKVAG 381

Query: 384 DSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKS--NHPGLLSEKA 441
           D ++G+C+V   +     GFVL P+   L++G  FL+ G + LF I+      G  +E  
Sbjct: 382 DELTGLCYVASTDAAALTGFVLVPLSGYLVLGSSFLLTGFVALFHIRKIMKTGGTNTE-- 439

Query: 442 ASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTK 501
             K+ + M+++G+F  L          C+ Y+  N   W     +   C A    G    
Sbjct: 440 --KLEKLMVKIGVFSILYTVPATCVIVCYVYERLNMDFWRLRATEQP-CAAAAGPGGRRD 496

Query: 502 QPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWR 546
             +P   +   P++ V  + +F     GI    WVW+  T   W+
Sbjct: 497 CSLPGGSV---PTVAVFMLKIFMSLVVGITSGVWVWSSKTFQTWQ 538


>gi|56117838 secreted frizzled-related protein 1 [Homo sapiens]
          Length = 314

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 31/85 (36%), Positives = 43/85 (50%), Gaps = 6/85 (7%)

Query: 95  DSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPC 154
           + ++  E   +   W  L N   C A  Q  LC+++ P C  DR   P R LC+A R  C
Sbjct: 83  EHETMAEVKQQASSWVPLLNK-NCHAGTQVFLCSLFAPVCL-DRPIYPCRWLCEAVRDSC 140

Query: 155 AIVERERG--WPDFLRCTPDRFPEG 177
             V +  G  WP+ L+C  D+FPEG
Sbjct: 141 EPVMQFFGFYWPEMLKC--DKFPEG 163


>gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens]
          Length = 641

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 37/126 (29%), Positives = 54/126 (42%), Gaps = 6/126 (4%)

Query: 67  AAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNA--PRCWAVIQP 124
           AA C  L+   C  +   +     LL   S    EA  + +L S L      +C   ++ 
Sbjct: 29  AATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRL 88

Query: 125 LLCAVYMPKCENDRVELPSRTLCQATRGPC--AIVERERGWPDFLRCTP--DRFPEGCTN 180
           L CAV  P+CE   V  P R +C+  R  C  A    +  WP FL C     R  EGC +
Sbjct: 89  LGCAVLAPRCEGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYD 148

Query: 181 EVQNIK 186
            ++ ++
Sbjct: 149 PLEKLR 154


>gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens]
          Length = 652

 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 39/138 (28%), Positives = 57/138 (41%), Gaps = 11/138 (7%)

Query: 60  PLSHCGR-----AAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRN 114
           P   C R     +A C  L+   C  +   +     LL   S    EA  + +L S L  
Sbjct: 28  PAGECHRPPAADSATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQ 87

Query: 115 A--PRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPC--AIVERERGWPDFLRCT 170
               +C   ++ L CAV  P+CE   V  P R +C+  R  C  A    +  WP FL C 
Sbjct: 88  LLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCH 147

Query: 171 P--DRFPEGCTNEVQNIK 186
               R  EGC + ++ ++
Sbjct: 148 RYFTREDEGCYDPLEKLR 165


>gi|188528609 secreted frizzled-related protein 5 [Homo sapiens]
          Length = 317

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 25/63 (39%), Positives = 34/63 (53%), Gaps = 5/63 (7%)

Query: 115 APRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERG--WPDFLRCTPD 172
           A RC +  Q  LC+++ P C  DR   P R+LC+A R  CA +    G  WP+ L C   
Sbjct: 97  AKRCHSDTQVFLCSLFAPVCL-DRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHC--H 153

Query: 173 RFP 175
           +FP
Sbjct: 154 KFP 156


>gi|170784838 secreted frizzled-related  protein 4 [Homo sapiens]
          Length = 346

 Score = 42.7 bits (99), Expect = 0.001
 Identities = 32/110 (29%), Positives = 52/110 (47%), Gaps = 10/110 (9%)

Query: 66  RAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPL 125
           R APCE +R  +C    +P+  T         +QE A   +  +  L +   C AV++  
Sbjct: 20  RGAPCEAVRIPMCRH--MPWNITRMPNHLHHSTQENAILAIEQYEELVDV-NCSAVLRFF 76

Query: 126 LCAVYMPKCE----NDRVELPSRTLCQATRGPCAIVER--ERGWPDFLRC 169
           LCA+Y P C     +D ++ P +++CQ  R  C  + +     WP+ L C
Sbjct: 77  LCAMYAPICTLEFLHDPIK-PCKSVCQRARDDCEPLMKMYNHSWPESLAC 125


>gi|38455388 frizzled-related protein [Homo sapiens]
          Length = 325

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 31/109 (28%), Positives = 47/109 (43%), Gaps = 8/109 (7%)

Query: 66  RAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPL 125
           RAA CEP+R  +C    LP+  T         +Q  A   +  + GL     C   +   
Sbjct: 31  RAAACEPVRIPLC--KSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGT-HCSPDLLFF 87

Query: 126 LCAVYMPKCEND---RVELPSRTLCQATRGPC--AIVERERGWPDFLRC 169
           LCA+Y P C  D       P +++C+  R  C   +++    WP+ L C
Sbjct: 88  LCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLAC 136


>gi|13899255 membrane frizzled-related protein [Homo sapiens]
          Length = 579

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 37/126 (29%), Positives = 53/126 (42%), Gaps = 12/126 (9%)

Query: 57  PPPPLSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAP 116
           PPP L+       CEP++  +CLG      A   +  G   +QEE    L  +  L + P
Sbjct: 460 PPPELA-------CEPVQVEMCLGLSYNTTAFPNIWVG-MITQEEVVEVLSGYKSLTSLP 511

Query: 117 RCWAVIQPLLCAVYMPKCEN-DRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFP 175
            C+   + LLC + +P+C     V  P R++CQ     C       G P    C  +R P
Sbjct: 512 -CYQHFRRLLCGLLVPRCTPLGSVLPPCRSVCQEAEHQCQSGLALLGTPWPFNC--NRLP 568

Query: 176 EGCTNE 181
           E    E
Sbjct: 569 EAADLE 574


>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
           sapiens]
          Length = 2715

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 34/108 (31%), Positives = 42/108 (38%), Gaps = 32/108 (29%)

Query: 658 EAEISPELQKRLGRKKKRRKRKKEVCPLA-------PPPELHPPAPAPSTIPRLPQLPRQ 710
           E +   E + + G +K+ R   +E+ P A       PPP L PPAP+P      P LP  
Sbjct: 366 EEKKEEEEKDKEGEEKEERAVAEEMMPAAEKEEAKLPPPPLTPPAPSPP-----PPLPPP 420

Query: 711 KCLVAAGAWGAGDSCRQGAWTLVSNPFCPEPSPP-QDPFLPSAPAPVA 757
                               T    P CP P PP   P LPS P P A
Sbjct: 421 S-------------------TSPPPPLCPPPPPPVSPPPLPSPPPPPA 449



 Score = 36.2 bits (82), Expect = 0.12
 Identities = 34/123 (27%), Positives = 47/123 (38%), Gaps = 20/123 (16%)

Query: 640 TPVATPVPPEEQANLWLVEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPS 699
           TP +TPVP  E+    L E         R                L PPP   PP PAPS
Sbjct: 588 TPPSTPVPLPEKRRSILREPTFRWTSLTR---------------ELPPPPPAPPPPPAPS 632

Query: 700 TIPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVS-----NPFCPEPSPPQDPFLPSAPA 754
             P      R+  L+ A  +   ++  +   ++++      P  PEP PP     P+ P 
Sbjct: 633 PPPAPATSSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGAPEAPEPEPPPADDSPAEPE 692

Query: 755 PVA 757
           P A
Sbjct: 693 PRA 695



 Score = 33.1 bits (74), Expect = 1.0
 Identities = 44/167 (26%), Positives = 58/167 (34%), Gaps = 23/167 (13%)

Query: 619 AQHVTKMVARRGAILPQDISVTP-VATPVPPEEQAN--------LWLVEAEISPELQKRL 669
           +Q   +  AR G       + TP  AT  PPE+           L  +   I P +  R 
Sbjct: 477 SQRAEREAARAGPEGTSPPTPTPSTATGGPPEDSPTVAPKSTTFLKNIRQFIMPVVSARS 536

Query: 670 GRKKKRRKR----------KKEVCP-LAPPPELHPPAPA-PSTIPRLPQLPRQKCLVAAG 717
            R  K  +R          K EV P L PP    PP P  P+ +P  P+ P         
Sbjct: 537 SRVIKTPRRFMDEDPPKPPKVEVSPVLRPPITTSPPVPQEPAPVPSPPRAPTPPSTPVPL 596

Query: 718 AWGAGDSCRQGA--WTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGR 762
                   R+    WT ++    P P  P  P  PS P   A +  R
Sbjct: 597 PEKRRSILREPTFRWTSLTRELPPPPPAPPPPPAPSPPPAPATSSRR 643



 Score = 30.0 bits (66), Expect = 8.7
 Identities = 16/38 (42%), Positives = 20/38 (52%), Gaps = 1/38 (2%)

Query: 665 LQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIP 702
           L+ + GR  + R RK +  PL PPP L   AP P   P
Sbjct: 141 LRSQRGRAPRGRGRKHKTTPL-PPPRLADVAPTPPKTP 177


>gi|29244926 corin [Homo sapiens]
          Length = 1042

 Score = 40.0 bits (92), Expect = 0.008
 Identities = 36/122 (29%), Positives = 53/122 (43%), Gaps = 11/122 (9%)

Query: 58  PPPLSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPR 117
           P   SH   +A C  + ++ C   +LPY AT T L     + E    K + +    +   
Sbjct: 128 PGDQSHRNTSA-CMNITHSQC--QMLPYHATLTPLLSVVRNMEME--KFLKFFTYLHRLS 182

Query: 118 CWAVIQPLLCAVYMPKCENDRVE----LPSRTLCQATRGPCAIVER--ERGWPDFLRCTP 171
           C+  I    C +  P+C  D  +    LP R+ C+A +  C  V       WPDFLRC+ 
Sbjct: 183 CYQHIMLFGCTLAFPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQ 242

Query: 172 DR 173
            R
Sbjct: 243 FR 244


>gi|166706868 synaptopodin 2-like isoform a [Homo sapiens]
          Length = 977

 Score = 39.7 bits (91), Expect = 0.011
 Identities = 44/184 (23%), Positives = 74/184 (40%), Gaps = 17/184 (9%)

Query: 579 LLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDIS 638
           L+   G +L  ++  ++ +GPV         PS       +          GA +PQ + 
Sbjct: 72  LIDASGNQLVLTVQRLADEGPV-------QSPSPHELQVLSPLSPLSPEPPGAPVPQPLQ 124

Query: 639 VTPVATPVPPEEQANLWLVEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELH----PP 694
             P +   PP+ +A     +++      +   R+ +RR   +   P APP E++    P 
Sbjct: 125 --PGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPA 182

Query: 695 APAPSTIPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNPFCP-EPSPPQDPFLPSAP 753
            PAP TIP  P     +  V++ +W  G + +      +  P  P  P P   P +   P
Sbjct: 183 EPAP-TIPGPPSQGDSR--VSSPSWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVP 239

Query: 754 APVA 757
            PVA
Sbjct: 240 HPVA 243


>gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]
          Length = 1682

 Score = 38.9 bits (89), Expect = 0.019
 Identities = 42/146 (28%), Positives = 54/146 (36%), Gaps = 10/146 (6%)

Query: 620 QHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAEISPELQKRLGRKKKRRKRK 679
           +H     A+RG    +  +  PV  PVPP   +     E  +SP  ++R G   ++    
Sbjct: 183 EHKRNYGAKRGGPPVKRAAEPPVVQPVPPAALSGP-SGEEGLSPGGKRRRGCNSEQTGLP 241

Query: 680 KEVCPLAPPPELHPPAPAPSTIPRLPQLPRQK--CLVAAGAWGAGDSCRQGAWTLVSNPF 737
             + PL PPP   PP P P   P LP L       L   G W    +    AW       
Sbjct: 242 PGL-PLPPPPLPPPPPPPPPPPPPLPGLATSPPFQLTKPGLW---STLHGDAWGPERKGS 297

Query: 738 CPEPSPPQDPFLPSA---PAPVAWAH 760
            P     Q   LP     PAP   AH
Sbjct: 298 APPERQEQRHSLPHPYPYPAPAYTAH 323


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 38.5 bits (88), Expect = 0.024
 Identities = 38/127 (29%), Positives = 50/127 (39%), Gaps = 11/127 (8%)

Query: 634 PQDISVTPVATPVPPEEQANLWLVEAEISPELQKR--LGRKKKRRKRKKEVCPLAPPPEL 691
           P     +P+ TP PPE  +++     +  P L      G             P APP   
Sbjct: 568 PLQAPPSPLTTP-PPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLA 626

Query: 692 HPPAPAPSTIPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNPFCPEPSPP-QDPFLP 750
            PP  AP + P  P L       +  A  +  +    A  L+  PF P PSPP Q PF P
Sbjct: 627 LPPLQAPPSPPASPPL-------SPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSP 679

Query: 751 SAPAPVA 757
            A  PV+
Sbjct: 680 PASPPVS 686



 Score = 30.0 bits (66), Expect = 8.7
 Identities = 30/99 (30%), Positives = 36/99 (36%), Gaps = 25/99 (25%)

Query: 684 PLAPPPELHPPAPAPSTIPRLPQL-------PRQKCLVAAGAWGAGDS------------ 724
           P APPP   PP   P + P  P +       PR   L+AA       S            
Sbjct: 724 PQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAK 783

Query: 725 -CRQGAWTLVSNPFCPEPSPP-----QDPFLPSAPAPVA 757
              Q    L + P    PSPP     Q PF PSA  P++
Sbjct: 784 PPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMS 822


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 38.1 bits (87), Expect = 0.032
 Identities = 29/75 (38%), Positives = 35/75 (46%), Gaps = 2/75 (2%)

Query: 684 PLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNPFCPEPSP 743
           PLA PP   PPA A   +   P  P    L +  A  +  +    A  L+  PF P PSP
Sbjct: 388 PLATPPPQAPPALALPPLQAPPSPPASPPL-SPLATPSPQAPNALAVHLLQAPFSPPPSP 446

Query: 744 P-QDPFLPSAPAPVA 757
           P Q PF P A  PV+
Sbjct: 447 PVQAPFSPPASPPVS 461



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 39/143 (27%), Positives = 55/143 (38%), Gaps = 20/143 (13%)

Query: 634 PQDISVTPVATPVPPEEQA-NLWLVEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELH 692
           P    ++P+ATP P    A  + L++A  SP     + +          V P A PP   
Sbjct: 412 PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPV-QAPFSPPASPPVSPSATPPSQA 470

Query: 693 PPAPA----------PSTIPRLPQL---PRQKCLVAAGAWGAGDSCRQGAWTLVSNPFCP 739
           PP+ A          P++ P  P     P+    +AA          Q    L + P   
Sbjct: 471 PPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQA 530

Query: 740 EPSPP-----QDPFLPSAPAPVA 757
            PSPP     Q PF PSA  P++
Sbjct: 531 LPSPPASFPGQAPFSPSASLPMS 553


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 38.1 bits (87), Expect = 0.032
 Identities = 29/75 (38%), Positives = 35/75 (46%), Gaps = 2/75 (2%)

Query: 684 PLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNPFCPEPSP 743
           PLA PP   PPA A   +   P  P    L +  A  +  +    A  L+  PF P PSP
Sbjct: 349 PLATPPPQAPPALALPPLQAPPSPPASPPL-SPLATPSPQAPNALAVHLLQAPFSPPPSP 407

Query: 744 P-QDPFLPSAPAPVA 757
           P Q PF P A  PV+
Sbjct: 408 PVQAPFSPPASPPVS 422



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 39/143 (27%), Positives = 55/143 (38%), Gaps = 20/143 (13%)

Query: 634 PQDISVTPVATPVPPEEQA-NLWLVEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELH 692
           P    ++P+ATP P    A  + L++A  SP     + +          V P A PP   
Sbjct: 373 PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPV-QAPFSPPASPPVSPSATPPSQA 431

Query: 693 PPAPA----------PSTIPRLPQL---PRQKCLVAAGAWGAGDSCRQGAWTLVSNPFCP 739
           PP+ A          P++ P  P     P+    +AA          Q    L + P   
Sbjct: 432 PPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQA 491

Query: 740 EPSPP-----QDPFLPSAPAPVA 757
            PSPP     Q PF PSA  P++
Sbjct: 492 LPSPPASFPGQAPFSPSASLPMS 514


>gi|145386517 phostensin [Homo sapiens]
          Length = 613

 Score = 38.1 bits (87), Expect = 0.032
 Identities = 30/84 (35%), Positives = 39/84 (46%), Gaps = 6/84 (7%)

Query: 676 RKRKKEVCPLAPPPE--LHPPAPAPSTIPRLPQLPRQKCLVAAGAWGAG-DSCRQGAWTL 732
           R++++E   L PPP   L PP PAP T P+ P  P    L      G G  + R+   T 
Sbjct: 414 RQQEEEAVELQPPPPAPLSPPPPAP-TAPQPPGDPLMSRLFYGVKAGPGVGAPRRSGHTF 472

Query: 733 VSNPFCPEPSPPQDPFLPSAPAPV 756
             NP      PP  P  P++PA V
Sbjct: 473 TVNP--RRSVPPATPATPTSPATV 494


>gi|199559805 phostensin [Homo sapiens]
          Length = 613

 Score = 38.1 bits (87), Expect = 0.032
 Identities = 30/84 (35%), Positives = 39/84 (46%), Gaps = 6/84 (7%)

Query: 676 RKRKKEVCPLAPPPE--LHPPAPAPSTIPRLPQLPRQKCLVAAGAWGAG-DSCRQGAWTL 732
           R++++E   L PPP   L PP PAP T P+ P  P    L      G G  + R+   T 
Sbjct: 414 RQQEEEAVELQPPPPAPLSPPPPAP-TAPQPPGDPLMSRLFYGVKAGPGVGAPRRSGHTF 472

Query: 733 VSNPFCPEPSPPQDPFLPSAPAPV 756
             NP      PP  P  P++PA V
Sbjct: 473 TVNP--RRSVPPATPATPTSPATV 494


>gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens]
          Length = 502

 Score = 37.7 bits (86), Expect = 0.042
 Identities = 37/110 (33%), Positives = 42/110 (38%), Gaps = 11/110 (10%)

Query: 684 PLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWGAG-------DSCRQGAWTLVSNP 736
           P+ PPP   PP P+    P  P LP    LV AG    G       D  RQG   L   P
Sbjct: 392 PMPPPPPPPPPPPSSGNGPAPPPLP--PALVPAGGLAPGGGRGALLDQIRQGI-QLNKTP 448

Query: 737 FCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTELMDADSD 786
             PE S  Q P   S     A  H  ++    IHS     D +  D D D
Sbjct: 449 GAPESSALQPPPQSSEGLVGALMHVMQKRSRAIHSSDEGED-QAGDEDED 497


>gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapiens]
          Length = 1955

 Score = 37.7 bits (86), Expect = 0.042
 Identities = 23/71 (32%), Positives = 27/71 (38%), Gaps = 23/71 (32%)

Query: 683  CPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNPFCPEPS 742
            CPL PPP + PP+P P+  P  P        +                      FCP PS
Sbjct: 1745 CPLPPPPPISPPSPPPAPAPLAPPPDISPFSL----------------------FCPPPS 1782

Query: 743  PPQDPFLPSAP 753
            PP  P LP  P
Sbjct: 1783 PPSIP-LPLPP 1792



 Score = 36.2 bits (82), Expect = 0.12
 Identities = 27/79 (34%), Positives = 34/79 (43%), Gaps = 14/79 (17%)

Query: 684  PLAPPPELHP-----PAPAPSTIPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNPFC 738
            PLAPPP++ P     P P+P +IP LP  P     ++            G  T    P  
Sbjct: 1764 PLAPPPDISPFSLFCPPPSPPSIP-LPLPPPTFFPLSVST--------SGPPTPPLLPPF 1814

Query: 739  PEPSPPQDPFLPSAPAPVA 757
            P P PP  P +P  P P A
Sbjct: 1815 PTPLPPPPPSIPCPPPPSA 1833


>gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sapiens]
          Length = 1932

 Score = 37.7 bits (86), Expect = 0.042
 Identities = 23/71 (32%), Positives = 27/71 (38%), Gaps = 23/71 (32%)

Query: 683  CPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNPFCPEPS 742
            CPL PPP + PP+P P+  P  P        +                      FCP PS
Sbjct: 1722 CPLPPPPPISPPSPPPAPAPLAPPPDISPFSL----------------------FCPPPS 1759

Query: 743  PPQDPFLPSAP 753
            PP  P LP  P
Sbjct: 1760 PPSIP-LPLPP 1769



 Score = 36.2 bits (82), Expect = 0.12
 Identities = 27/79 (34%), Positives = 34/79 (43%), Gaps = 14/79 (17%)

Query: 684  PLAPPPELHP-----PAPAPSTIPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNPFC 738
            PLAPPP++ P     P P+P +IP LP  P     ++            G  T    P  
Sbjct: 1741 PLAPPPDISPFSLFCPPPSPPSIP-LPLPPPTFFPLSVST--------SGPPTPPLLPPF 1791

Query: 739  PEPSPPQDPFLPSAPAPVA 757
            P P PP  P +P  P P A
Sbjct: 1792 PTPLPPPPPSIPCPPPPSA 1810


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.444 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,439,832
Number of Sequences: 37866
Number of extensions: 1907070
Number of successful extensions: 13308
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 60
Number of HSP's successfully gapped in prelim test: 256
Number of HSP's that attempted gapping in prelim test: 11887
Number of HSP's gapped (non-prelim): 1408
length of query: 787
length of database: 18,247,518
effective HSP length: 110
effective length of query: 677
effective length of database: 14,082,258
effective search space: 9533688666
effective search space used: 9533688666
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.