Guide to the Human Genome
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Name: SMO Sequence: fasta or formatted (787aa) NCBI GI: 5032099
Description:

smoothened

Referenced in:

Hedgehog and Related Pathways
Wnt Signals

Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             9.4         74           3
 C cysteine            3.3         26           1
 D aspartate           3.7         29           2
 E glutamate           4.7         37           2
 F phenylalanine       4.7         37           2
 G glycine             7.8         61           2
 H histidine           1.9         15           1
 I isoleucine          4.2         33           2
 K lysine              3.7         29           3
 L leucine            10.3         81           7
 M methionine          1.9         15           1
 N asparagine          3.2         25           1
 P proline             8.3         65           4
 Q glutamine           3.3         26           1
 R arginine            6.2         49           2
 S serine              6.6         52           2
 T threonine           5.5         43           2
 V valine              6.7         53           2
 W tryptophan          2.4         19           1
 Y tyrosine            2.3         18           2
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   smoothened 
FZD1                  0.105   frizzled 1 
FZD5                  0.098   frizzled 5 precursor 
FZD7                  0.098   frizzled 7 
FZD2                  0.093   frizzled 2 
FZD4                  0.092   frizzled 4 
FZD3                  0.088   frizzled 3 
FZD10                 0.086   frizzled 10 
FZD6                  0.086   frizzled 6 
FZD8                  0.083   frizzled 8 
FZD9                  0.080   frizzled 9 
SFRP1                 0.015   secreted frizzled-related protein 1 
CPZ                   0.014   carboxypeptidase Z isoform 2 precursor 
CPZ                   0.014   carboxypeptidase Z isoform 1 
SFRP5                 0.012   secreted frizzled-related protein 5 
SFRP4                 0.011   secreted frizzled-related  protein 4 
FRZB                  0.010   frizzled-related protein 
MFRP                  0.010   membrane frizzled-related protein 
MLL4                  0.010   myeloid/lymphoid or mixed-lineage leukemia 4 
CORIN                 0.009   corin 
SYNPO2L               0.009   synaptopodin 2-like isoform a 
KDM6B                 0.009   lysine (K)-specific demethylase 6B 
FLJ22184              0.009   PREDICTED: hypothetical protein FLJ22184 
FLJ22184              0.008   PREDICTED: hypothetical protein FLJ22184 
FLJ22184              0.008   PREDICTED: hypothetical protein LOC80164 
KIAA1949              0.008   phostensin 
KIAA1949              0.008   phostensin 
WAS                   0.008   Wiskott-Aldrich syndrome protein 
PCDH15                0.008   protocadherin 15 isoform CD1-4 precursor 
PCDH15                0.008   protocadherin 15 isoform CD1-10 precursor 
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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