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Search of human proteins with 50263044
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
(620 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 1254 0.0
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 752 0.0
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 625 e-179
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 469 e-132
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] 167 3e-41
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens] 167 3e-41
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens] 164 3e-40
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens] 164 3e-40
gi|51317373 netrin-G1 ligand [Homo sapiens] 164 3e-40
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens] 164 3e-40
gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens] 157 4e-38
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 155 8e-38
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 153 4e-37
gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 152 9e-37
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 152 1e-36
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 152 1e-36
gi|4759146 slit homolog 2 [Homo sapiens] 150 3e-36
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 149 6e-36
gi|11321571 slit homolog 3 [Homo sapiens] 149 1e-35
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 145 1e-34
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 145 1e-34
gi|188528675 slit homolog 1 [Homo sapiens] 142 7e-34
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 136 7e-32
gi|12007646 nyctalopin precursor [Homo sapiens] 131 2e-30
gi|198041768 synleurin [Homo sapiens] 130 4e-30
gi|31542244 leucine rich repeat and fibronectin type III domain ... 130 5e-30
gi|225579152 insulin-like growth factor binding protein, acid la... 129 6e-30
gi|4826772 insulin-like growth factor binding protein, acid labi... 129 6e-30
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 127 2e-29
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 126 5e-29
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 1254 bits (3246), Expect = 0.0
Identities = 620/620 (100%), Positives = 620/620 (100%)
Query: 1 MQVSKRMLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRK 60
MQVSKRMLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRK
Sbjct: 1 MQVSKRMLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRK 60
Query: 61 RFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFN 120
RFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFN
Sbjct: 61 RFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFN 120
Query: 121 LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV 180
LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV
Sbjct: 121 LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV 180
Query: 181 YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYR 240
YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYR
Sbjct: 181 YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYR 240
Query: 241 LKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS 300
LKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS
Sbjct: 241 LKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS 300
Query: 301 TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN 360
TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN
Sbjct: 301 TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN 360
Query: 361 LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFT 420
LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFT
Sbjct: 361 LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFT 420
Query: 421 CRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG 480
CRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG
Sbjct: 421 CRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG 480
Query: 481 TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGE 540
TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGE
Sbjct: 481 TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGE 540
Query: 541 ANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPR 600
ANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPR
Sbjct: 541 ANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPR 600
Query: 601 KSDAGISSADAPRKFNMKMI 620
KSDAGISSADAPRKFNMKMI
Sbjct: 601 KSDAGISSADAPRKFNMKMI 620
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 752 bits (1942), Expect = 0.0
Identities = 365/603 (60%), Positives = 468/603 (77%), Gaps = 4/603 (0%)
Query: 20 LACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLG 79
++CWQP L L + + GS GCP RCECSAQ+++V CHR+R +A+PEGIP ET++LDL
Sbjct: 6 ISCWQPFLGLAVVLIFMGSTIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLS 65
Query: 80 KNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVF 139
KNR+K++N +EF S+P LEE++L++NI++ VEPGAFNNLFNLR+L L+ NRLKL+PLGVF
Sbjct: 66 KNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVF 125
Query: 140 TGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLE 199
TGLSNLTKLDISENKIVILLDYMFQDL+NLKSLEVGDNDLVYISHRAFSGL SLEQLTLE
Sbjct: 126 TGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLE 185
Query: 200 KCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNC 259
KCNLT++PTEALSHL LI L L+HLNIN + Y+FKRL+ LK LEI +WP LD M N
Sbjct: 186 KCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANS 245
Query: 260 LYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLV 319
LYGLNLTSLS+T+ NL+ VP+LA +HLVYL LNLSYNPISTIE M +L+RLQE+ +V
Sbjct: 246 LYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIV 305
Query: 320 GGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLW 379
G QL +EP++F+GL +LRVLNVS N L TLEE+VF S LE L +++NPLACDCRLLW
Sbjct: 306 GAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLW 365
Query: 380 VFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVDEG 439
+ +R+ L F QQP CA P+ ++ + FKDF L YFTC++ +IR++K Q + VDEG
Sbjct: 366 ILQRQPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEG 425
Query: 440 HTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIA 499
TVQ C ADGDP P I W++PR+ ++ KSNGR TV DGTLE+R+AQ QD+G Y+CIA
Sbjct: 426 QTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIA 485
Query: 500 ANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKTLII 559
+NA GND+ A L V+ ++ D N+T ++++ + +N T A F D+KT+++
Sbjct: 486 SNAAGNDTFTASLTVKGFASDRFLYANRTPMYMTDS-NDTISNGTNANT-FSLDLKTILV 543
Query: 560 ATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPRKSDAGISSAD--APRKFNM 617
+T MG +FLGVVLFC +LLF+WSRGKG K++I++EYVPRK++ + + PR+FNM
Sbjct: 544 STAMGCFTFLGVVLFCFLLLFVWSRGKGKHKNSIDLEYVPRKNNGAVVEGEVAGPRRFNM 603
Query: 618 KMI 620
KMI
Sbjct: 604 KMI 606
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 625 bits (1612), Expect = e-179
Identities = 326/605 (53%), Positives = 420/605 (69%), Gaps = 17/605 (2%)
Query: 20 LACWQPILLL--VLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLD 77
+ CW +L L +L A GCP RCEC+ Q RAV C R+R AVP+GIP ETRLL+
Sbjct: 1 MTCWLCVLSLPLLLLPAAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLE 60
Query: 78 LGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLG 137
L +NRI+ LN + A+ P LEEL+L+EN ++ VEPGAF NL LR L LR N+LKLIP G
Sbjct: 61 LSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPG 120
Query: 138 VFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLT 197
VFT L NLT LD+SENK+VILLDY FQDL++L+ LEVGDNDLV++S RAF+GL +LE+LT
Sbjct: 121 VFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELT 180
Query: 198 LEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTP 257
LE+CNLT++ E+L HL L LRLRHL I ++ D +F+RL L LEI +WP L+ +
Sbjct: 181 LERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAA 240
Query: 258 NCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQ 317
L GLNLTSLS+TH N+TAVP A+RH +L LNLS+NPIST+ +L+RL+E+
Sbjct: 241 GSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELH 300
Query: 318 LVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRL 377
L G LAVVEP AF GL +R+LN+S N L+TLEES FHSV LETL +D NPLACDCRL
Sbjct: 301 LAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRL 360
Query: 378 LWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVD 437
LW+ +RR LNF+ + P CATP V+G ++ PD +L YF CR+ +IR+R+ Q+V
Sbjct: 361 LWIVQRRKTLNFDGRLPACATPAEVRGDALRNLPDSVLFEYFVCRKPKIRERRLQRVTAT 420
Query: 438 EGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLC 497
G V+F+CRA+G+P P + W++P+ V+A S GR V P GTLE++ A+ QD+GTY C
Sbjct: 421 AGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRARVLPGGTLEIQDARPQDSGTYTC 480
Query: 498 IAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKTL 557
+A+NAGGND+ A L VR N+T PGE N T A + P D+ T+
Sbjct: 481 VASNAGGNDTYFATLTVRP-----EPAANRT-------PGEAH-NETLAALRAPLDLTTI 527
Query: 558 IIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPRKSD--AGISSADAPRKF 615
+++T MG I+FLGVVLFC VLLF+WSRG+G K+N +EY RK D A + RKF
Sbjct: 528 LVSTAMGCITFLGVVLFCFVLLFVWSRGRGQHKNNFSVEYSFRKVDGPAAAAGQGGARKF 587
Query: 616 NMKMI 620
NMKMI
Sbjct: 588 NMKMI 592
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 469 bits (1206), Expect = e-132
Identities = 258/583 (44%), Positives = 355/583 (60%), Gaps = 21/583 (3%)
Query: 23 WQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNR 82
W P+L L+L + GS CP C+C++Q +AVLC ++ AVP G+P +T LLDL NR
Sbjct: 14 WPPLLFLLL--LPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNR 71
Query: 83 IKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGL 142
+ L Q + L+EL+L+ N +S +EPGAF+ L +L TL L+ NRL+++ GVF+GL
Sbjct: 72 LWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGL 131
Query: 143 SNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCN 202
S LT LD+ N+IV+ LD F +L +L+ LEVGDN LV+++ AF+GL L LTLE+CN
Sbjct: 132 SALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCN 191
Query: 203 LTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYG 262
L+++P AL+ L L+ LRLR L+I + + + L +LK LEI WP L+ + P L G
Sbjct: 192 LSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVG 251
Query: 263 LNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQ 322
LNL+SL+IT CNL++VP+ A+ HL +LR L+LS NPIS I L L+RLQE++L G
Sbjct: 252 LNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGAC 311
Query: 323 LAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFR 382
L + +AF GL +L+V+ N L TLEE+ F S L TL L NPL CDCRLLW+ R
Sbjct: 312 LTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLR 371
Query: 383 RRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVDEGHTV 442
R L+F P CA P VQGK K+F D+L P +FTC+ A IR + V +EG
Sbjct: 372 LRRHLDFGMSPPACAGPHHVQGKSLKEFSDILPPGHFTCKPALIRKSGPRWVIAEEGGHA 431
Query: 443 QFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANA 502
F C DGDP P + W+ P H GR+ V DGTLE+R Q++D G Y+C+ +N
Sbjct: 432 VFSCSGDGDPAPTVSWMRP--HGAWLGRAGRVRVLEDGTLEIRSVQLRDRGAYVCVVSNV 489
Query: 503 GGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPF--DIKTLIIA 560
GNDS+ L V P PN T + + N T +P PF D + + +
Sbjct: 490 AGNDSLRTWLEVIQVEP-----PNGTLS---------DPNITVPGIPGPFFLDSRGVAMV 535
Query: 561 TTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYV-PRKS 602
+GF+ FL V C L+ LWS+GKG KH++ ++V PR S
Sbjct: 536 LAVGFLPFLTSVTLCFGLIALWSKGKGRVKHHMTFDFVAPRPS 578
>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 167 bits (422), Expect = 3e-41
Identities = 148/540 (27%), Positives = 235/540 (43%), Gaps = 77/540 (14%)
Query: 12 VRSMPSPLLACWQPILLLVLGSVLSGSATG----CPPRCECSAQD-----------RAVL 56
+R + +PLL W V G+ + CPP+C C + V
Sbjct: 1 MRLLVAPLLLAW------VAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVD 54
Query: 57 CHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFN 116
C+ AVP +P T+ L L N I ++Q E +L EL+L++N S F+
Sbjct: 55 CNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFH 114
Query: 117 NLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGD 176
L L L + EN++ L D+ F L +L+ L +
Sbjct: 115 ------------------------ALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNH 150
Query: 177 NDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFK 236
N L I+ RAFSGL++L +L L L +I + L L +L + ++AI D +F+
Sbjct: 151 NQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFR 210
Query: 237 RLYRLKVLEISHWPYLDTMTPNCLYGL-NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLS 295
L L+ L ++ L ++ L GL +L SLS L VP A+ + L+FL+L+
Sbjct: 211 PLANLRSLVLAGMN-LREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLN 269
Query: 296 YNPISTIE----GSMLH----------ELLRLQEIQLVG------------GQLAVVEPY 329
NP+ + +MLH EL+ + + LV +L+ + P
Sbjct: 270 KNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPR 329
Query: 330 AFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNF 389
AF L + L ++ N L+ L + S+ NL+ + L NP+ CDC + W R+ F
Sbjct: 330 AFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVRF 389
Query: 390 NRQQPT-CATPEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVDEGHTVQFVCRA 448
Q T CA P +Q ++ P + ++ C + V G ++ CRA
Sbjct: 390 IEPQSTLCAEPPDLQRLPVREVPFREMTDH--CLPLISPRSFPPSLQVASGESMVLHCRA 447
Query: 449 DGDPPPAILWLSPR-KHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDS 507
+P P I W++P L A + R V+P+GTLE+R ++ G Y C+A N G D+
Sbjct: 448 LAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYTCVAQNLVGADT 507
>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 167 bits (422), Expect = 3e-41
Identities = 148/540 (27%), Positives = 235/540 (43%), Gaps = 77/540 (14%)
Query: 12 VRSMPSPLLACWQPILLLVLGSVLSGSATG----CPPRCECSAQD-----------RAVL 56
+R + +PLL W V G+ + CPP+C C + V
Sbjct: 1 MRLLVAPLLLAW------VAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVD 54
Query: 57 CHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFN 116
C+ AVP +P T+ L L N I ++Q E +L EL+L++N S F+
Sbjct: 55 CNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFH 114
Query: 117 NLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGD 176
L L L + EN++ L D+ F L +L+ L +
Sbjct: 115 ------------------------ALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNH 150
Query: 177 NDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFK 236
N L I+ RAFSGL++L +L L L +I + L L +L + ++AI D +F+
Sbjct: 151 NQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFR 210
Query: 237 RLYRLKVLEISHWPYLDTMTPNCLYGL-NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLS 295
L L+ L ++ L ++ L GL +L SLS L VP A+ + L+FL+L+
Sbjct: 211 PLANLRSLVLAGMN-LREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLN 269
Query: 296 YNPISTIE----GSMLH----------ELLRLQEIQLVG------------GQLAVVEPY 329
NP+ + +MLH EL+ + + LV +L+ + P
Sbjct: 270 KNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPR 329
Query: 330 AFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNF 389
AF L + L ++ N L+ L + S+ NL+ + L NP+ CDC + W R+ F
Sbjct: 330 AFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVRF 389
Query: 390 NRQQPT-CATPEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVDEGHTVQFVCRA 448
Q T CA P +Q ++ P + ++ C + V G ++ CRA
Sbjct: 390 IEPQSTLCAEPPDLQRLPVREVPFREMTDH--CLPLISPRSFPPSLQVASGESMVLHCRA 447
Query: 449 DGDPPPAILWLSPR-KHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDS 507
+P P I W++P L A + R V+P+GTLE+R ++ G Y C+A N G D+
Sbjct: 448 LAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYTCVAQNLVGADT 507
>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 164 bits (414), Expect = 3e-40
Identities = 126/436 (28%), Positives = 191/436 (43%), Gaps = 60/436 (13%)
Query: 78 LGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLG 137
L +N++ L + + +L+EL +N N++S + PGAF L NL L L SNRL++I
Sbjct: 123 LEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSK 182
Query: 138 VFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLT 197
F L NL L I EN I+ + D F+ L NL+SL + +L I A GL +LE ++
Sbjct: 183 WFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESIS 242
Query: 198 LEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTP 257
L +P AL + L L L IN IR F + LK L I++ P
Sbjct: 243 FYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMP------- 295
Query: 258 NCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQ 317
L ++ LAV +L LR + + NP
Sbjct: 296 ----------------ELISIDSLAVDNLPDLRKIEATNNP------------------- 320
Query: 318 LVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRL 377
+L+ + P AF L L L ++ N L+ L S+ NL+ + + SNP+ CDC +
Sbjct: 321 ----RLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVI 376
Query: 378 LWVFRRRWRLNFNRQQPT-CATPEFVQGK-----EFKDFPDVLLPNYFTCRRARIRDRKA 431
W+ + + F C P QG+ F+D ++ LP +
Sbjct: 377 RWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLP-------LIAPESFP 429
Query: 432 QQVFVDEGHTVQFVCRADGDPPPAILWLSPR-KHLVSAKSNGRLTVFPDGTLEVRYAQVQ 490
+ V+ G V F CRA +P P I W++P + L+ + V +GTL++ +
Sbjct: 430 SNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPK 489
Query: 491 DNGTYLCIAANAGGND 506
+ G Y CIA N G D
Sbjct: 490 EGGLYTCIATNLVGAD 505
Score = 60.8 bits (146), Expect = 3e-09
Identities = 34/111 (30%), Positives = 62/111 (55%)
Query: 261 YGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVG 320
+ +NLT L ++ NL++V + V+ + L + L N ++ + L EL LQE+ +
Sbjct: 90 FPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINH 149
Query: 321 GQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPL 371
L+ + P AF GL+ L L+++ N+L + F ++ NLE L++ NP+
Sbjct: 150 NLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPI 200
Score = 37.0 bits (84), Expect = 0.054
Identities = 18/66 (27%), Positives = 34/66 (51%)
Query: 67 EGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGL 126
+ +P ++ R+ ++ + F P LE L LN N +SA+ G +L NL+ + +
Sbjct: 306 DNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISI 365
Query: 127 RSNRLK 132
SN ++
Sbjct: 366 HSNPIR 371
>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 164 bits (414), Expect = 3e-40
Identities = 126/436 (28%), Positives = 191/436 (43%), Gaps = 60/436 (13%)
Query: 78 LGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLG 137
L +N++ L + + +L+EL +N N++S + PGAF L NL L L SNRL++I
Sbjct: 123 LEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSK 182
Query: 138 VFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLT 197
F L NL L I EN I+ + D F+ L NL+SL + +L I A GL +LE ++
Sbjct: 183 WFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESIS 242
Query: 198 LEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTP 257
L +P AL + L L L IN IR F + LK L I++ P
Sbjct: 243 FYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMP------- 295
Query: 258 NCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQ 317
L ++ LAV +L LR + + NP
Sbjct: 296 ----------------ELISIDSLAVDNLPDLRKIEATNNP------------------- 320
Query: 318 LVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRL 377
+L+ + P AF L L L ++ N L+ L S+ NL+ + + SNP+ CDC +
Sbjct: 321 ----RLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVI 376
Query: 378 LWVFRRRWRLNFNRQQPT-CATPEFVQGK-----EFKDFPDVLLPNYFTCRRARIRDRKA 431
W+ + + F C P QG+ F+D ++ LP +
Sbjct: 377 RWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLP-------LIAPESFP 429
Query: 432 QQVFVDEGHTVQFVCRADGDPPPAILWLSPR-KHLVSAKSNGRLTVFPDGTLEVRYAQVQ 490
+ V+ G V F CRA +P P I W++P + L+ + V +GTL++ +
Sbjct: 430 SNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPK 489
Query: 491 DNGTYLCIAANAGGND 506
+ G Y CIA N G D
Sbjct: 490 EGGLYTCIATNLVGAD 505
Score = 60.8 bits (146), Expect = 3e-09
Identities = 34/111 (30%), Positives = 62/111 (55%)
Query: 261 YGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVG 320
+ +NLT L ++ NL++V + V+ + L + L N ++ + L EL LQE+ +
Sbjct: 90 FPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINH 149
Query: 321 GQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPL 371
L+ + P AF GL+ L L+++ N+L + F ++ NLE L++ NP+
Sbjct: 150 NLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPI 200
Score = 37.0 bits (84), Expect = 0.054
Identities = 18/66 (27%), Positives = 34/66 (51%)
Query: 67 EGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGL 126
+ +P ++ R+ ++ + F P LE L LN N +SA+ G +L NL+ + +
Sbjct: 306 DNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISI 365
Query: 127 RSNRLK 132
SN ++
Sbjct: 366 HSNPIR 371
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 164 bits (414), Expect = 3e-40
Identities = 138/451 (30%), Positives = 221/451 (49%), Gaps = 25/451 (5%)
Query: 122 RTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVY 181
+ + +R N L+ +P G+ T N L++ EN+I I+ F+ L +L+ L++ N +
Sbjct: 59 KVICVRKN-LREVPDGIST---NTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRT 114
Query: 182 ISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRL 241
I AF+GL +L L L LT+IP A +L L L LR+ I +I Y+F R+ L
Sbjct: 115 IEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSL 174
Query: 242 KVLEISHWPYLDTMTPNCLYGL-NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS 300
+ L++ L ++ GL NL L++ CNL +P L L+ L L+LS N +S
Sbjct: 175 RRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTP--LIKLDELDLSGNHLS 232
Query: 301 TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN 360
I L+ LQ++ ++ Q+ V+E AF L L +N++ N LT L +F + +
Sbjct: 233 AIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHH 292
Query: 361 LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPT-----CATPEFVQGKEFKDFPDVLL 415
LE + L NP C+C +LW+ W + T C TP ++G+ + L
Sbjct: 293 LERIHLHHNPWNCNCDILWL---SWWIKDMAPSNTACCARCNTPPNLKGRYIGE----LD 345
Query: 416 PNYFTCRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVS-AKSNGRL 474
NYFTC I + A + V EG + CRA ++ W++P +++ R+
Sbjct: 346 QNYFTCYAPVIVEPPA-DLNVTEGMAAELKCRA-STSLTSVSWITPNGTVMTHGAYKVRI 403
Query: 475 TVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISN 534
V DGTL VQD G Y C+ +N+ GN + A L+V + + P T +
Sbjct: 404 AVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNVTA-ATTTPFSYFSTVTVETM 462
Query: 535 QPGEGEANSTRATV-PFP-FDIKTLIIATTM 563
+P + EA +T V P P D +T + T++
Sbjct: 463 EPSQDEARTTDNNVGPTPVVDWETTNVTTSL 493
Score = 156 bits (395), Expect = 5e-38
Identities = 108/288 (37%), Positives = 156/288 (54%), Gaps = 7/288 (2%)
Query: 13 RSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTE 72
R++ PLL + LLV+ ++ A CP C CS Q V+C RK VP+GI T
Sbjct: 20 RALFDPLLVVLLALQLLVVAGLVR--AQTCPSVCSCSNQFSKVICVRKNLREVPDGISTN 77
Query: 73 TRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLK 132
TRLL+L +N+I+ + + F HLE L+L+ N + +E GAFN L NL TL L NRL
Sbjct: 78 TRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLT 137
Query: 133 LIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGD-NDLVYISHRAFSGLN 191
IP G F LS L +L + N I + Y F + +L+ L++G+ L YIS AF GL+
Sbjct: 138 TIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLS 197
Query: 192 SLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPY 251
+L L L CNL IP L+ L L L L +++AIR SF+ L L+ L +
Sbjct: 198 NLRYLNLAMCNLREIPN--LTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQ-SQ 254
Query: 252 LDTMTPNCLYGL-NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNP 298
+ + N L +L +++ H NLT +P+ L +L ++L +NP
Sbjct: 255 IQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNP 302
>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 164 bits (414), Expect = 3e-40
Identities = 126/436 (28%), Positives = 191/436 (43%), Gaps = 60/436 (13%)
Query: 78 LGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLG 137
L +N++ L + + +L+EL +N N++S + PGAF L NL L L SNRL++I
Sbjct: 123 LEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSK 182
Query: 138 VFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLT 197
F L NL L I EN I+ + D F+ L NL+SL + +L I A GL +LE ++
Sbjct: 183 WFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESIS 242
Query: 198 LEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTP 257
L +P AL + L L L IN IR F + LK L I++ P
Sbjct: 243 FYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMP------- 295
Query: 258 NCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQ 317
L ++ LAV +L LR + + NP
Sbjct: 296 ----------------ELISIDSLAVDNLPDLRKIEATNNP------------------- 320
Query: 318 LVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRL 377
+L+ + P AF L L L ++ N L+ L S+ NL+ + + SNP+ CDC +
Sbjct: 321 ----RLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVI 376
Query: 378 LWVFRRRWRLNFNRQQPT-CATPEFVQGK-----EFKDFPDVLLPNYFTCRRARIRDRKA 431
W+ + + F C P QG+ F+D ++ LP +
Sbjct: 377 RWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLP-------LIAPESFP 429
Query: 432 QQVFVDEGHTVQFVCRADGDPPPAILWLSPR-KHLVSAKSNGRLTVFPDGTLEVRYAQVQ 490
+ V+ G V F CRA +P P I W++P + L+ + V +GTL++ +
Sbjct: 430 SNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPK 489
Query: 491 DNGTYLCIAANAGGND 506
+ G Y CIA N G D
Sbjct: 490 EGGLYTCIATNLVGAD 505
Score = 60.8 bits (146), Expect = 3e-09
Identities = 34/111 (30%), Positives = 62/111 (55%)
Query: 261 YGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVG 320
+ +NLT L ++ NL++V + V+ + L + L N ++ + L EL LQE+ +
Sbjct: 90 FPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINH 149
Query: 321 GQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPL 371
L+ + P AF GL+ L L+++ N+L + F ++ NLE L++ NP+
Sbjct: 150 NLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPI 200
Score = 37.0 bits (84), Expect = 0.054
Identities = 18/66 (27%), Positives = 34/66 (51%)
Query: 67 EGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGL 126
+ +P ++ R+ ++ + F P LE L LN N +SA+ G +L NL+ + +
Sbjct: 306 DNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISI 365
Query: 127 RSNRLK 132
SN ++
Sbjct: 366 HSNPIR 371
>gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]
Length = 716
Score = 157 bits (396), Expect = 4e-38
Identities = 130/535 (24%), Positives = 225/535 (42%), Gaps = 64/535 (11%)
Query: 19 LLACWQPILLLVLGSVLSGSATG--CPPRCECSAQD-----------RAVLCHRKRFVAV 65
++A Q +L L++ S+ S CP C C + V C+ R +
Sbjct: 7 VIAACQLVLGLLMTSLTESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRI 66
Query: 66 PEGIPTETRLL-----------------------DLGKNRIKTLNQDEFASFPHLEELEL 102
P + ++T++L D +N + + A+ L L L
Sbjct: 67 PSNLSSDTQVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHL 126
Query: 103 NENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYM 162
EN ++ + +L NL+ L + N++ I F GL NL +L ++ NK+ ++
Sbjct: 127 EENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRW 186
Query: 163 FQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRL 222
F NL+ L +G+N ++ I F L +L L L LT IP AL L L L
Sbjct: 187 FDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSF 246
Query: 223 RHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHC-NLTAVPYL 281
+ + + +++ LK L+++ P + L L L I + L +V
Sbjct: 247 YDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRY 306
Query: 282 AVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLN 341
A+ +L L L + NP +L+ + AFR + L L
Sbjct: 307 ALDNLPELTKLEATNNP-----------------------KLSYIHRLAFRSVPALESLM 343
Query: 342 VSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQ-QPTCATPE 400
++ N L + + S+ NL + + SNPL CDC + W+ + + F CA P
Sbjct: 344 LNNNALNAIYQKTVESLPNLREISIHSNPLRCDCVIHWINSNKTNIRFMEPLSMFCAMPP 403
Query: 401 FVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLS 460
+G + K+ ++ + C D ++ VD G TV CRA +P P I W++
Sbjct: 404 EYKGHQVKEV--LIQDSSEQCLPMISHDSFPNRLNVDIGTTVFLDCRAMAEPEPEIYWVT 461
Query: 461 PRKHLVSAKS-NGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHV 514
P + ++ ++ + + + +GTLE+ Q++D+G Y C+A N G D+ A + V
Sbjct: 462 PIGNKITVETLSDKYKLSSEGTLEISNIQIEDSGRYTCVAQNVQGADTRVATIKV 516
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 155 bits (393), Expect = 8e-38
Identities = 122/383 (31%), Positives = 187/383 (48%), Gaps = 18/383 (4%)
Query: 144 NLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNL 203
N L++ EN I ++ F+ L +L+ L++ N + I AF+GL SL L L L
Sbjct: 87 NTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRL 146
Query: 204 TSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGL 263
T++PT+A +L L L LR+ I +I Y+F R+ L+ L++ L+ ++ GL
Sbjct: 147 TTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGL 206
Query: 264 -NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQ 322
NL L++ CNL +P L LV L L LS N + I L L+++ L+ Q
Sbjct: 207 VNLRYLNLGMCNLKDIPNLTA--LVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQ 264
Query: 323 LAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFR 382
+A +E AF L L LN+S N L +L +F + LE + L+ NP C+C +LW+
Sbjct: 265 VATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWL-- 322
Query: 383 RRWRLNFNRQQPT-----CATPEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVD 437
W L T C P ++G+ + L ++FTC A + + V
Sbjct: 323 -SWWLKETVPSNTTCCARCHAPAGLKGRYIGE----LDQSHFTC-YAPVIVEPPTDLNVT 376
Query: 438 EGHTVQFVCRADGDPPPAILWLSPRKHLVSAKS-NGRLTVFPDGTLEVRYAQVQDNGTYL 496
EG + CR G ++ WL+P L++ S R++V DGTL VQD G Y
Sbjct: 377 EGMAAELKCRT-GTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYT 435
Query: 497 CIAANAGGNDSMPAHLHVRSYSP 519
C+ N+ GN + A L+V + P
Sbjct: 436 CMVTNSAGNTTASATLNVSAVDP 458
Score = 147 bits (371), Expect = 3e-35
Identities = 100/265 (37%), Positives = 142/265 (53%), Gaps = 5/265 (1%)
Query: 36 SGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFP 95
S AT CP C CS Q V+C R+ VP IP TR L+L +N I+ + D F
Sbjct: 51 SPPATSCPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLR 110
Query: 96 HLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKI 155
HLE L+L++N+V +E GAFN L +L TL L NRL +P F LS L +L + N I
Sbjct: 111 HLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPI 170
Query: 156 VILLDYMFQDLYNLKSLEVGD-NDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHL 214
+ Y F + +L+ L++G+ L YIS AF GL +L L L CNL IP L+ L
Sbjct: 171 ESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPN--LTAL 228
Query: 215 HGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGL-NLTSLSITHC 273
L L L ++ IR SF+ L L+ L + H + T+ N L +L L+++H
Sbjct: 229 VRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMH-AQVATIERNAFDDLKSLEELNLSHN 287
Query: 274 NLTAVPYLAVRHLVYLRFLNLSYNP 298
NL ++P+ L L ++L++NP
Sbjct: 288 NLMSLPHDLFTPLHRLERVHLNHNP 312
Score = 46.6 bits (109), Expect = 7e-05
Identities = 29/85 (34%), Positives = 40/85 (47%)
Query: 287 VYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQ 346
V R+LNL N I I L L+ +QL + +E AF GL L L + N+
Sbjct: 86 VNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNR 145
Query: 347 LTTLEESVFHSVGNLETLILDSNPL 371
LTT+ F + L L L +NP+
Sbjct: 146 LTTVPTQAFEYLSKLRELWLRNNPI 170
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 153 bits (387), Expect = 4e-37
Identities = 127/437 (29%), Positives = 195/437 (44%), Gaps = 66/437 (15%)
Query: 23 WQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPT----------- 71
W +LLL + A CP C+C Q+ V C + VP IP
Sbjct: 9 WTSLLLL------ARPAQPCPMGCDCFVQE--VFCSDEELATVPLDIPPYTKNIIFVETS 60
Query: 72 ----ETRLLDLGKNRIKTL---------NQDEFASFPHLEELE----------------- 101
ETR N K + D F P LE+LE
Sbjct: 61 FTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNL 120
Query: 102 -------LNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENK 154
LN N++ A+ G F +L L +L L+ N+L+ +P +F L++L L++++N
Sbjct: 121 TSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNL 180
Query: 155 IVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHL 214
+ L + +F L +L++L++ +N L + F L SL++L L+ N++ +P + S L
Sbjct: 181 LAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQL 240
Query: 215 HGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLN--LTSLSITH 272
L L L+ I + F L L L + W L + P L+ L LS+TH
Sbjct: 241 FCLERLWLQRNAITHLPLSIFASLGNLTFLSLQ-WNMLRVL-PAGLFAHTPCLVGLSLTH 298
Query: 273 CNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFR 332
L V HL LR L LSYN I+ + + +L L ++ L L + P F+
Sbjct: 299 NQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQ 358
Query: 333 GLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQ 392
L+ L +L++S NQLTTL E +F + NL L L NP CDC L ++F W + +
Sbjct: 359 NLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLF--NWLQQYTDR 416
Query: 393 ----QPTCATPEFVQGK 405
Q CA P +++G+
Sbjct: 417 LLNIQTYCAGPAYLKGQ 433
>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
Length = 653
Score = 152 bits (384), Expect = 9e-37
Identities = 119/390 (30%), Positives = 188/390 (48%), Gaps = 20/390 (5%)
Query: 131 LKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGL 190
L +P G+ SN L++ EN I ++ F+ L++L+ L++G N + I AF+GL
Sbjct: 66 LSEVPQGI---PSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGL 122
Query: 191 NSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWP 250
SL L L LT IP+ A +L L L LR+ I +I Y+F R+ L L++
Sbjct: 123 ASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELK 182
Query: 251 YLDTMTPNCLYGL-NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHE 309
L+ ++ GL NL L++ CN+ +P L LV L L +S N I H
Sbjct: 183 KLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTP--LVGLEELEMSGNHFPEIRPGSFHG 240
Query: 310 LLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSN 369
L L+++ ++ Q++++E AF GL L LN++ N L++L +F + L L L N
Sbjct: 241 LSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHN 300
Query: 370 PLACDCRLLWVFRRRWRLNFNRQQPTCA----TPEFVQGKEFKDFPDVLLPNYFTCRRAR 425
P CDC +LW+ W + TC P ++G+ + F C
Sbjct: 301 PWNCDCDILWL--AWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQA----SFQCSAPF 354
Query: 426 IRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVS-AKSNGRLTVFPDGTLEV 484
I D + + + EG + CR P ++ WL P ++S A + R++V DGTL
Sbjct: 355 IMD-APRDLNISEGRMAELKCRT--PPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNF 411
Query: 485 RYAQVQDNGTYLCIAANAGGNDSMPAHLHV 514
+ + D G Y C+ N GN + A+L+V
Sbjct: 412 SHVLLSDTGVYTCMVTNVAGNSNASAYLNV 441
Score = 149 bits (376), Expect = 7e-36
Identities = 101/275 (36%), Positives = 144/275 (52%), Gaps = 5/275 (1%)
Query: 26 ILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKT 85
IL + + S CP C CS Q V+C R+ VP+GIP+ TR L+L +N I+
Sbjct: 30 ILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQM 89
Query: 86 LNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNL 145
+ D F HLE L+L N + +E GAFN L +L TL L N L +IP G F LS L
Sbjct: 90 IQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKL 149
Query: 146 TKLDISENKIVILLDYMFQDLYNLKSLEVGD-NDLVYISHRAFSGLNSLEQLTLEKCNLT 204
+L + N I + Y F + +L L++G+ L YIS AF GL +L+ L L CN+
Sbjct: 150 RELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIK 209
Query: 205 SIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGL- 263
+P L+ L GL L + + IR SF L LK L + + + + N GL
Sbjct: 210 DMPN--LTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMN-SQVSLIERNAFDGLA 266
Query: 264 NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNP 298
+L L++ H NL+++P+ L YL L+L +NP
Sbjct: 267 SLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNP 301
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 152 bits (383), Expect = 1e-36
Identities = 116/373 (31%), Positives = 178/373 (47%), Gaps = 30/373 (8%)
Query: 27 LLLVLGSVLSGSAT---GCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRI 83
LLL++G G+ GCP C CS + V C R VAVP +P L + I
Sbjct: 13 LLLLVGCQAWGAGLAYHGCPSECTCSRASQ-VECTGARIVAVPTPLPWNAMSLQILNTHI 71
Query: 84 KTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLS 143
LN+ F + L L + +N +S + PGAF NL +LR L L +N+L+++P+G+F GL
Sbjct: 72 TELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLD 131
Query: 144 NLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNL 203
+L L +S N+++ + F NLK L++ N L YI AF L L +L L K +L
Sbjct: 132 SLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSL 191
Query: 204 TSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLY-G 262
T I HL L VLRL + I +F L L+ L + + ++P +
Sbjct: 192 THISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQ-NQIGLLSPGLFHNN 250
Query: 263 LNLTSLSITHCNLTAVPYLAVRHLVY------------------------LRFLNLSYNP 298
NL L +++ +++ +P L LR L L N
Sbjct: 251 HNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNH 310
Query: 299 ISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSV 358
IS++ ++ L +LQ + L Q++ + P AF GL LR L++ N L L+ +VF +
Sbjct: 311 ISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRML 370
Query: 359 GNLETLILDSNPL 371
NL+ + L +N L
Sbjct: 371 ANLQNISLQNNRL 383
Score = 75.1 bits (183), Expect = 2e-13
Identities = 49/154 (31%), Positives = 79/154 (51%), Gaps = 1/154 (0%)
Query: 69 IPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRS 128
+P RL G N +K L+ F P+L EL L +N +S++ F+NL L+ L L
Sbjct: 274 LPQLNRLTLFG-NSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSR 332
Query: 129 NRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFS 188
N++ I G F GL+ L +L + N + L +F+ L NL+++ + +N L + F+
Sbjct: 333 NQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFA 392
Query: 189 GLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRL 222
+N L + L+ L ++P HL L LRL
Sbjct: 393 NVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRL 426
Score = 71.2 bits (173), Expect = 3e-12
Identities = 52/163 (31%), Positives = 84/163 (51%), Gaps = 8/163 (4%)
Query: 76 LDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIP 135
L L +N+I L+ F + +L+ L L+ N +S + P F L L L L N LK +
Sbjct: 232 LALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELS 291
Query: 136 LGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQ 195
LG+F + NL +L + +N I L D +F +L L+ L + N + +IS AF+GL L +
Sbjct: 292 LGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRE 351
Query: 196 LTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRL 238
L+L T AL L G + L +L ++++ ++L
Sbjct: 352 LSLH--------TNALQDLDGNVFRMLANLQNISLQNNRLRQL 386
Score = 68.6 bits (166), Expect = 2e-11
Identities = 61/229 (26%), Positives = 98/229 (42%), Gaps = 21/229 (9%)
Query: 76 LDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIP 135
L L N I L F P L L L N + + G F + NLR L L N + +P
Sbjct: 256 LYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLP 315
Query: 136 LGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQ 195
VF+ L L L +S N+I + F L L+ L + N L + F L +L+
Sbjct: 316 DNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQN 375
Query: 196 LTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRL-------------- 241
++L+ L +P ++++GL+ ++L++ + + F L +L
Sbjct: 376 ISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDS 435
Query: 242 KVLEISHW-----PYLDTMT-PNCLYGLNLTSLSITHCNL-TAVPYLAV 283
+L + +W P L T T P C N+ S+ N+ AVP + V
Sbjct: 436 DILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHV 484
Score = 67.8 bits (164), Expect = 3e-11
Identities = 56/206 (27%), Positives = 95/206 (46%)
Query: 167 YNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLN 226
+N SL++ + + ++ F +++L L +EK L+ I A +L L L L +
Sbjct: 59 WNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNK 118
Query: 227 INAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHL 286
+ + F+ L L+ L +S L + NL L + +L +P A HL
Sbjct: 119 LQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHL 178
Query: 287 VYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQ 346
V L LNL N ++ I + L LQ ++L +L + F GL L+ L + NQ
Sbjct: 179 VGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQ 238
Query: 347 LTTLEESVFHSVGNLETLILDSNPLA 372
+ L +FH+ NL+ L L +N ++
Sbjct: 239 IGLLSPGLFHNNHNLQRLYLSNNHIS 264
Score = 53.1 bits (126), Expect = 7e-07
Identities = 29/106 (27%), Positives = 55/106 (51%)
Query: 72 ETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRL 131
+ ++L L +N+I ++ F L EL L+ N + ++ F L NL+ + L++NRL
Sbjct: 324 QLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRL 383
Query: 132 KLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDN 177
+ +P +F ++ L + + N++ L +F L L L + DN
Sbjct: 384 RQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 429
Score = 46.6 bits (109), Expect = 7e-05
Identities = 25/83 (30%), Positives = 45/83 (54%)
Query: 71 TETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNR 130
TE R L L N ++ L+ + F +L+ + L N + + F N+ L + L++N+
Sbjct: 347 TELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQ 406
Query: 131 LKLIPLGVFTGLSNLTKLDISEN 153
L+ +PLG+F L L +L + +N
Sbjct: 407 LENLPLGIFDHLGKLCELRLYDN 429
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 152 bits (383), Expect = 1e-36
Identities = 116/373 (31%), Positives = 178/373 (47%), Gaps = 30/373 (8%)
Query: 27 LLLVLGSVLSGSAT---GCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRI 83
LLL++G G+ GCP C CS + V C R VAVP +P L + I
Sbjct: 7 LLLLVGCQAWGAGLAYHGCPSECTCSRASQ-VECTGARIVAVPTPLPWNAMSLQILNTHI 65
Query: 84 KTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLS 143
LN+ F + L L + +N +S + PGAF NL +LR L L +N+L+++P+G+F GL
Sbjct: 66 TELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLD 125
Query: 144 NLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNL 203
+L L +S N+++ + F NLK L++ N L YI AF L L +L L K +L
Sbjct: 126 SLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSL 185
Query: 204 TSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLY-G 262
T I HL L VLRL + I +F L L+ L + + ++P +
Sbjct: 186 THISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQ-NQIGLLSPGLFHNN 244
Query: 263 LNLTSLSITHCNLTAVPYLAVRHLVY------------------------LRFLNLSYNP 298
NL L +++ +++ +P L LR L L N
Sbjct: 245 HNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNH 304
Query: 299 ISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSV 358
IS++ ++ L +LQ + L Q++ + P AF GL LR L++ N L L+ +VF +
Sbjct: 305 ISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRML 364
Query: 359 GNLETLILDSNPL 371
NL+ + L +N L
Sbjct: 365 ANLQNISLQNNRL 377
Score = 75.1 bits (183), Expect = 2e-13
Identities = 49/154 (31%), Positives = 79/154 (51%), Gaps = 1/154 (0%)
Query: 69 IPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRS 128
+P RL G N +K L+ F P+L EL L +N +S++ F+NL L+ L L
Sbjct: 268 LPQLNRLTLFG-NSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSR 326
Query: 129 NRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFS 188
N++ I G F GL+ L +L + N + L +F+ L NL+++ + +N L + F+
Sbjct: 327 NQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFA 386
Query: 189 GLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRL 222
+N L + L+ L ++P HL L LRL
Sbjct: 387 NVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRL 420
Score = 71.2 bits (173), Expect = 3e-12
Identities = 52/163 (31%), Positives = 84/163 (51%), Gaps = 8/163 (4%)
Query: 76 LDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIP 135
L L +N+I L+ F + +L+ L L+ N +S + P F L L L L N LK +
Sbjct: 226 LALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELS 285
Query: 136 LGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQ 195
LG+F + NL +L + +N I L D +F +L L+ L + N + +IS AF+GL L +
Sbjct: 286 LGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRE 345
Query: 196 LTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRL 238
L+L T AL L G + L +L ++++ ++L
Sbjct: 346 LSLH--------TNALQDLDGNVFRMLANLQNISLQNNRLRQL 380
Score = 68.6 bits (166), Expect = 2e-11
Identities = 61/229 (26%), Positives = 98/229 (42%), Gaps = 21/229 (9%)
Query: 76 LDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIP 135
L L N I L F P L L L N + + G F + NLR L L N + +P
Sbjct: 250 LYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLP 309
Query: 136 LGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQ 195
VF+ L L L +S N+I + F L L+ L + N L + F L +L+
Sbjct: 310 DNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQN 369
Query: 196 LTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRL-------------- 241
++L+ L +P ++++GL+ ++L++ + + F L +L
Sbjct: 370 ISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDS 429
Query: 242 KVLEISHW-----PYLDTMT-PNCLYGLNLTSLSITHCNL-TAVPYLAV 283
+L + +W P L T T P C N+ S+ N+ AVP + V
Sbjct: 430 DILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHV 478
Score = 67.8 bits (164), Expect = 3e-11
Identities = 56/206 (27%), Positives = 95/206 (46%)
Query: 167 YNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLN 226
+N SL++ + + ++ F +++L L +EK L+ I A +L L L L +
Sbjct: 53 WNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNK 112
Query: 227 INAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHL 286
+ + F+ L L+ L +S L + NL L + +L +P A HL
Sbjct: 113 LQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHL 172
Query: 287 VYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQ 346
V L LNL N ++ I + L LQ ++L +L + F GL L+ L + NQ
Sbjct: 173 VGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQ 232
Query: 347 LTTLEESVFHSVGNLETLILDSNPLA 372
+ L +FH+ NL+ L L +N ++
Sbjct: 233 IGLLSPGLFHNNHNLQRLYLSNNHIS 258
Score = 53.1 bits (126), Expect = 7e-07
Identities = 29/106 (27%), Positives = 55/106 (51%)
Query: 72 ETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRL 131
+ ++L L +N+I ++ F L EL L+ N + ++ F L NL+ + L++NRL
Sbjct: 318 QLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRL 377
Query: 132 KLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDN 177
+ +P +F ++ L + + N++ L +F L L L + DN
Sbjct: 378 RQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 423
Score = 46.6 bits (109), Expect = 7e-05
Identities = 25/83 (30%), Positives = 45/83 (54%)
Query: 71 TETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNR 130
TE R L L N ++ L+ + F +L+ + L N + + F N+ L + L++N+
Sbjct: 341 TELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQ 400
Query: 131 LKLIPLGVFTGLSNLTKLDISEN 153
L+ +PLG+F L L +L + +N
Sbjct: 401 LENLPLGIFDHLGKLCELRLYDN 423
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 150 bits (379), Expect = 3e-36
Identities = 114/388 (29%), Positives = 175/388 (45%), Gaps = 44/388 (11%)
Query: 23 WQPILL---LVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLG 79
WQ + L LVL + + CP +C CS V CH +VP IP T LDL
Sbjct: 6 WQMLSLSLGLVLAILNKVAPQACPAQCSCSGS--TVDCHGLALRSVPRNIPRNTERLDLN 63
Query: 80 KNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVF 139
N I + + +FA HL L+L EN +S +E GAF +L L L L N L+L P +F
Sbjct: 64 GNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLF 123
Query: 140 TGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLE 199
G + L +LD+SEN+I + F+ ++K+L++ N + I AF L LE LTL
Sbjct: 124 LGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLN 183
Query: 200 KCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNC 259
N+T + + +H+ L RL N+ ++ + + + Y M P+
Sbjct: 184 NNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVG--LYTQCMGPSH 241
Query: 260 LYGLNLT------------------SLSITHC----------------NLTAVPYLAVRH 285
L G N+ S S+ HC LT +P
Sbjct: 242 LRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPET 301
Query: 286 LVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGN 345
+ +R L N I I +L+ I L Q++ + P AF+GL L L + GN
Sbjct: 302 ITEIR---LEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGN 358
Query: 346 QLTTLEESVFHSVGNLETLILDSNPLAC 373
++T L +S+F + +L+ L+L++N + C
Sbjct: 359 KITELPKSLFEGLFSLQLLLLNANKINC 386
Score = 116 bits (291), Expect = 5e-26
Identities = 120/455 (26%), Positives = 194/455 (42%), Gaps = 78/455 (17%)
Query: 36 SGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFP 95
S S CP C CS + V C K +P +P + L +N IK + F+ +
Sbjct: 267 SCSVLHCPAACTCS--NNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYK 324
Query: 96 HLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKI 155
L ++L+ N +S + P AF L +L +L L N++ +P +F GL +L L ++ NKI
Sbjct: 325 KLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKI 384
Query: 156 VILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEK------CNLTSI--- 206
L FQDL+NL L + DN L I+ FS L +++ + L + C+L +
Sbjct: 385 NCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADY 444
Query: 207 ----PTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYG 262
P E S RL + I I+ F+ + + Y ++ +C
Sbjct: 445 LHTNPIET-SGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDCFAD 503
Query: 263 LNL--------TSLSITHCNLTAVP-----YLA-----------------VRHLVYLRFL 292
L T++ ++ L +P Y A + L LR +
Sbjct: 504 LACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKI 563
Query: 293 NLSYNPISTIE------GSMLHELL----RLQEIQ--------------LVGGQLAVVEP 328
N S N I+ IE S ++E+L RL+ +Q L ++ V
Sbjct: 564 NFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGN 623
Query: 329 YAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLN 388
+F GL+ +R+L++ NQ+TT+ F ++ +L TL L +NP C+C L W+ +
Sbjct: 624 DSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRKKR 683
Query: 389 FNRQQPTCATPEFVQGKEFKDFP--DVLLPNYFTC 421
P C P F+ K+ P DV + + FTC
Sbjct: 684 IVTGNPRCQKPYFL-----KEIPIQDVAIQD-FTC 712
Score = 113 bits (282), Expect = 6e-25
Identities = 103/385 (26%), Positives = 166/385 (43%), Gaps = 45/385 (11%)
Query: 33 SVLSGSA---TGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQD 89
S LSG CP +C C + V C ++ +PE IP T L L N L
Sbjct: 494 SKLSGDCFADLACPEKCRC--EGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEAT 551
Query: 90 E-FASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKL 148
F P L ++ + N ++ +E GAF + + L SNRL+ + +F GL +L L
Sbjct: 552 GIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTL 611
Query: 149 DISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPT 208
+ N+I + + F L +++ L + DN + ++ AF L+SL L NL + P
Sbjct: 612 MLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTL-----NLLANPF 666
Query: 209 EALSHLHGLIV-LRLRHL---NINAIRDYSFKRLYRLKVL----------------EISH 248
+L L LR + + N + Y K + V +S
Sbjct: 667 NCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSR 726
Query: 249 WPY----LDTMTPNCLYGL---------NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLS 295
P LDT+ GL ++T L + T VP + + +L ++LS
Sbjct: 727 CPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPK-ELSNYKHLTLIDLS 785
Query: 296 YNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVF 355
N IST+ + +L + L +L + P F GL LR+L++ GN ++ + E F
Sbjct: 786 NNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAF 845
Query: 356 HSVGNLETLILDSNPLACDCRLLWV 380
+ + L L + +NPL CDC + W+
Sbjct: 846 NDLSALSHLAIGANPLYCDCNMQWL 870
Score = 68.6 bits (166), Expect = 2e-11
Identities = 66/219 (30%), Positives = 94/219 (42%), Gaps = 40/219 (18%)
Query: 194 EQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISH----- 248
E+L L N+T I + L L VL+L I+ I +F+ L L+ L ++
Sbjct: 58 ERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQL 117
Query: 249 WPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLH 308
+P L + LY L+L+ I A+P A R V ++ L L YN IS IE
Sbjct: 118 FPELLFLGTAKLYRLDLSENQIQ-----AIPRKAFRGAVDIKNLQLDYNQISCIEDG--- 169
Query: 309 ELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDS 368
AFR L L VL ++ N +T L + F+ + L T L S
Sbjct: 170 ---------------------AFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHS 208
Query: 369 NPLACDCRLLWV---FRRRWRLNFNRQQPTCATPEFVQG 404
N L CDC L W+ R+R R+ Q C P ++G
Sbjct: 209 NNLYCDCHLAWLSDWLRQRPRVGLYTQ---CMGPSHLRG 244
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 149 bits (377), Expect = 6e-36
Identities = 114/360 (31%), Positives = 180/360 (50%), Gaps = 12/360 (3%)
Query: 15 MPSPL-LACWQPILLLVLGSVLSGSATGCPPRCE--CSAQ-DRAVLCHRKRFVAVPEGIP 70
MP PL L C+ + L +LGS +G + PP C CS DR V C K AVPEG+
Sbjct: 1 MPGPLGLLCF--LALGLLGS--AGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLS 56
Query: 71 TETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNR 130
T+ LD+ N I L +D F +FP LEEL+L N +S + P A + L L+ L L++N+
Sbjct: 57 AFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQ 116
Query: 131 LKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGL 190
LK +P GLS L L + N I + + F+ L L+ L + DN L + S L
Sbjct: 117 LKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNL 176
Query: 191 NSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWP 250
+L+ LTL ++SIP A ++L L+VL L + I ++ + F L L+ L++++
Sbjct: 177 PTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNN 236
Query: 251 YLDTMTPNCLYGL-NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHE 309
+ P + L +L L +++ +P A LR ++L NP+S + S H
Sbjct: 237 LGE--FPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHN 294
Query: 310 LLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSN 369
L L + + G + P G +L L ++G +++++ ++ L TL L N
Sbjct: 295 LSDLHSLVIRGASMVQQFP-NLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYN 353
Score = 70.5 bits (171), Expect = 4e-12
Identities = 56/185 (30%), Positives = 96/185 (51%), Gaps = 3/185 (1%)
Query: 189 GLNSLEQ-LTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEIS 247
GL++ Q L + N+T +P +A + L L+L +++ I + L LKVL +
Sbjct: 54 GLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQ 113
Query: 248 HWPYLDTMTPNCLYGLN-LTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSM 306
+ L T+ + GL+ L SL + ++T+VP + LV LR L L N ++ +
Sbjct: 114 N-NQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHP 172
Query: 307 LHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLIL 366
L L LQ + L +++ + +AF L+ L VL++ N++ +L + F + NLETL L
Sbjct: 173 LSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDL 232
Query: 367 DSNPL 371
+ N L
Sbjct: 233 NYNNL 237
Score = 57.0 bits (136), Expect = 5e-08
Identities = 39/122 (31%), Positives = 61/122 (50%), Gaps = 2/122 (1%)
Query: 96 HLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKI 155
HLE L L +S++ LRTL L N ++ +P F G L ++ + N+I
Sbjct: 320 HLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQI 377
Query: 156 VILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLH 215
+ + FQ L +L+ L++ N + I RAF+ L + L + LTS PTE L+ L+
Sbjct: 378 YQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLN 437
Query: 216 GL 217
L
Sbjct: 438 QL 439
Score = 43.5 bits (101), Expect = 6e-04
Identities = 34/118 (28%), Positives = 55/118 (46%), Gaps = 10/118 (8%)
Query: 85 TLNQDEFASFPH--------LEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPL 136
TL + +S P+ L L+L+ N + + +FN L + L+ N++ I
Sbjct: 325 TLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLP--SFNGCHALEEISLQRNQIYQIKE 382
Query: 137 GVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLE 194
G F GL +L LD+S N I + F L + +L+V N+L +GLN L+
Sbjct: 383 GTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLK 440
Score = 34.3 bits (77), Expect = 0.35
Identities = 25/99 (25%), Positives = 43/99 (43%), Gaps = 4/99 (4%)
Query: 76 LDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIP 135
+ L +N+I + + F L L+L+ N++ + AF L + L + N L P
Sbjct: 370 ISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFP 429
Query: 136 LGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEV 174
GL+ L + + K + +D NL+SL V
Sbjct: 430 TEGLNGLNQLKLVGNFKLKEALAA----KDFVNLRSLSV 464
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 149 bits (375), Expect = 1e-35
Identities = 117/385 (30%), Positives = 186/385 (48%), Gaps = 47/385 (12%)
Query: 27 LLLVLGSVLSGS-ATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKT 85
L L L SVLSG A CP +C CSA +V CH AVP GIP LDL +N I
Sbjct: 18 LALALASVLSGPPAVACPTKCTCSAA--SVDCHGLGLRAVPRGIPRNAERLDLDRNNITR 75
Query: 86 LNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNL 145
+ + +FA +L L L +N VS +E GAF +L L L L N+L+++P +F L
Sbjct: 76 ITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKL 135
Query: 146 TKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTS 205
T+LD+SEN+I + F+ + ++K+L++ +N + I AF L LE LTL N++
Sbjct: 136 TRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISR 195
Query: 206 IPTEALSHLHGLIVLRL--RHL----NINAIRDYSFKR--------------LYRLKVLE 245
I + +H+ + LRL HL ++ + D+ +R L V +
Sbjct: 196 ILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVAD 255
Query: 246 ISHWPYL----DTMTPNCLYGLNLTSLS----------ITHC---NLTAVPYLAVRHLVY 288
+ Y+ + P+C N S+S I C L +P +V
Sbjct: 256 VQKKEYVCPAPHSEPPSC----NANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVE 311
Query: 289 LRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLT 348
+R L N I I + +L+ I + Q++ + P AF+GL L L + GN++T
Sbjct: 312 IR---LEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKIT 368
Query: 349 TLEESVFHSVGNLETLILDSNPLAC 373
+ + +F + +L+ L+L++N + C
Sbjct: 369 EIAKGLFDGLVSLQLLLLNANKINC 393
Score = 120 bits (302), Expect = 3e-27
Identities = 118/451 (26%), Positives = 187/451 (41%), Gaps = 78/451 (17%)
Query: 36 SGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFP 95
+ ++ CP C CS + V C K + +P +P + L +N IK + F +
Sbjct: 274 NANSISCPSPCTCS--NNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYK 331
Query: 96 HLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKI 155
L+ +++++N +S + P AF L +L +L L N++ I G+F GL +L L ++ NKI
Sbjct: 332 KLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKI 391
Query: 156 VILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLH 215
L FQDL NL L + DN L IS F+ L S++ L +L P HL
Sbjct: 392 NCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTL-----HLAQNPFVCDCHLK 446
Query: 216 GLI-VLRLRHLNINAIRDYSFKRLYRLKVLEI--------SHWPYLDTMTPNCLYGL--- 263
L L+ + + R S +RL ++ +I Y + C L
Sbjct: 447 WLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRSRFSSECFMDLVCP 506
Query: 264 -----NLTSLSITHCNLTAVP-----YLA-----------------VRHLVYLRFLNLSY 296
T + ++ L +P Y+ + L LR +NLS
Sbjct: 507 EKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSN 566
Query: 297 NPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYL------------------- 337
N I + +QE+ L G QL V FRGL+ L
Sbjct: 567 NKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFA 626
Query: 338 -----RVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQ 392
R+L++ N++TT+ F ++ +L T+ L SNP C+C L W+ + +
Sbjct: 627 GLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSG 686
Query: 393 QPTCATPEFVQGKEFKDFP--DVLLPNYFTC 421
P C P F+ K+ P DV + + FTC
Sbjct: 687 NPRCQKPFFL-----KEIPIQDVAIQD-FTC 711
Score = 115 bits (289), Expect = 9e-26
Identities = 107/377 (28%), Positives = 167/377 (44%), Gaps = 51/377 (13%)
Query: 42 CPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDE-FASFPHLEEL 100
CP +C C + V C ++ V +P +P L L N + L F P+L ++
Sbjct: 505 CPEKCRC--EGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKI 562
Query: 101 ELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLD 160
L+ N + V GAF+ +++ L L N+L+ + VF GLS L L + N I + +
Sbjct: 563 NLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSN 622
Query: 161 YMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIV- 219
F L +++ L + DN + I+ AF+ L SL + NL S P HL L
Sbjct: 623 DTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTI-----NLLSNPFNCNCHLAWLGKW 677
Query: 220 LRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLD-----------TMTPNC--------- 259
LR R + R ++ + LK + I D ++P C
Sbjct: 678 LRKRRIVSGNPR---CQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMET 734
Query: 260 --------LYGL------NLTSLSITHCNLTAVP--YLAVRHLVYLRFLNLSYNPISTIE 303
L L ++T L + +LTAVP A+RHL ++LS N IS +
Sbjct: 735 VVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLT---LIDLSNNSISMLT 791
Query: 304 GSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLET 363
+ L + L +L + +AF GL LRVL + GN ++++ E F+ + +L
Sbjct: 792 NYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSH 851
Query: 364 LILDSNPLACDCRLLWV 380
L L +NPL CDC L W+
Sbjct: 852 LALGTNPLHCDCSLRWL 868
Score = 64.7 bits (156), Expect = 2e-10
Identities = 67/298 (22%), Positives = 118/298 (39%), Gaps = 48/298 (16%)
Query: 194 EQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLD 253
E+L L++ N+T I + L L VL L ++ I +F+ L +L+ L
Sbjct: 64 ERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLR-------- 115
Query: 254 TMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRL 313
LN L + +P L + L L+LS N I I + +
Sbjct: 116 ---------LNKNKLQV-------LPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDV 159
Query: 314 QEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLAC 373
+ +QL ++ +E AFR L L +L ++ N ++ + + F+ + + TL L SN L C
Sbjct: 160 KNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYC 219
Query: 374 DCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQ 433
DC L W+ + Q C P ++G + D + ++
Sbjct: 220 DCHLAWLSDWLRQRRTVGQFTLCMAPVHLRG-------------------FNVADVQKKE 260
Query: 434 VFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTV---FPDGTLEVRYAQ 488
H+ C A+ P+ S ++V + G + + P+G +E+R Q
Sbjct: 261 YVCPAPHSEPPSCNANSISCPSPCTCS--NNIVDCRGKGLMEIPANLPEGIVEIRLEQ 316
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 145 bits (366), Expect = 1e-34
Identities = 141/466 (30%), Positives = 225/466 (48%), Gaps = 43/466 (9%)
Query: 76 LDLGKNRIKTLNQDEFASFP--HLEELELNENIVSAVEPGAFNNLFN-LRTLGLRSNRLK 132
LDL N I L +FP L+ L LN N V+++EPG F+NL N L L L NR+
Sbjct: 150 LDLSSNNISELQ----TAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRIS 205
Query: 133 LIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNS 192
IP +F L L L+++ NKI + FQ L LKSL++ N + + AF GL++
Sbjct: 206 AIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSN 264
Query: 193 LEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYS---FKRLYRLKVLEISHW 249
+E L L+ NLT I L+GL++L+ HL+ NAI S ++ +L L+++ +
Sbjct: 265 MEILQLDHNNLTEITK---GWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLT-F 320
Query: 250 PYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLA---VRHLVYLRFLNLSYNPIS-TIE-- 303
+L + + GL+L L+ H V Y+A R L L+ L+L N IS TIE
Sbjct: 321 NHLSRLDDSSFLGLSL--LNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDM 378
Query: 304 GSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLET 363
L +L+ + L G ++ + AF GL+ L L++S N + +L+ + F + L+
Sbjct: 379 NGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQ 438
Query: 364 LILDSNPLACDCRLLWVFRRRWRLNFNRQ---QPTCATPEFVQGKE-FKDFPDVLLPNYF 419
L L+++ L CDC+L W+ +W N Q +CA P+ ++G+ F PD + + F
Sbjct: 439 LHLNTSSLLCDCQLKWL--PQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDF 496
Query: 420 TCRRARIRDRKAQQVFVDEGHTVQFVCRA--DGDPPPAILWLSPRKHLVSAKSNGRLTVF 477
+ ++ + +G + F+C A D P W + L A+ +
Sbjct: 497 PKPQITVQPETQSAI---KGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLR 553
Query: 478 PDG--------TLEVRYAQVQDNGTYLCIAAN-AGGNDSMPAHLHV 514
G L +R + G Y C+ +N G + S+ A L V
Sbjct: 554 AQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTV 599
Score = 73.6 bits (179), Expect = 5e-13
Identities = 118/514 (22%), Positives = 190/514 (36%), Gaps = 77/514 (14%)
Query: 58 HRKRFVAVPEGIPTETRL--LDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAF 115
+R R A+P + +L L+L +N+IK ++ F L+ L++ N V+ + GAF
Sbjct: 200 NRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAF 259
Query: 116 NNLFNLRTLGLRSNRLKLIPLGVFTGL------------------------SNLTKLDIS 151
L N+ L L N L I G GL L++LD++
Sbjct: 260 WGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLT 319
Query: 152 ENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEAL 211
N + L D F L L +L +G+N + YI+ AF GL+SL+ L L+ ++ +
Sbjct: 320 FNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMN 379
Query: 212 SHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLS-- 269
GL LR L N IR + K L LE +LD ++ N + L + S
Sbjct: 380 GAFSGLDKLRRLILQGNRIRSITKKAFTGLDALE-----HLD-LSDNAIMSLQGNAFSQM 433
Query: 270 --ITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVE 327
+ +L L L +L N S + S H L L G + V
Sbjct: 434 KKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQL------LKGRSIFAVS 487
Query: 328 PYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRL 387
P F V + T++ ++ + S + D + + +++ L
Sbjct: 488 PDGF-------VCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNEL 540
Query: 388 NFNRQQPTCATPEFVQGKEFKDFPDVL----------------LPNYF----------TC 421
+ + A QG E ++ +L + N+F T
Sbjct: 541 LHDAEMENYAHLR-AQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTV 599
Query: 422 RRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFP-DG 480
+ + + G + C A G P P I W A R+ V P D
Sbjct: 600 NMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDD 659
Query: 481 TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHV 514
+ +++D G Y C A N+ G+ S A L V
Sbjct: 660 VFFIVDVKIEDIGVYSCTAQNSAGSISANATLTV 693
Score = 32.3 bits (72), Expect = 1.3
Identities = 24/81 (29%), Positives = 32/81 (39%), Gaps = 6/81 (7%)
Query: 436 VDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDGT--LEVRYAQVQDNG 493
V +G T C A G PPP + W LV + + F G L + + V D G
Sbjct: 708 VTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERH----FFAAGNQLLIIVDSDVSDAG 763
Query: 494 TYLCIAANAGGNDSMPAHLHV 514
Y C +N G + L V
Sbjct: 764 KYTCEMSNTLGTERGNVRLSV 784
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 145 bits (366), Expect = 1e-34
Identities = 141/466 (30%), Positives = 225/466 (48%), Gaps = 43/466 (9%)
Query: 76 LDLGKNRIKTLNQDEFASFP--HLEELELNENIVSAVEPGAFNNLFN-LRTLGLRSNRLK 132
LDL N I L +FP L+ L LN N V+++EPG F+NL N L L L NR+
Sbjct: 90 LDLSSNNISELQ----TAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRIS 145
Query: 133 LIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNS 192
IP +F L L L+++ NKI + FQ L LKSL++ N + + AF GL++
Sbjct: 146 AIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSN 204
Query: 193 LEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYS---FKRLYRLKVLEISHW 249
+E L L+ NLT I L+GL++L+ HL+ NAI S ++ +L L+++ +
Sbjct: 205 MEILQLDHNNLTEITK---GWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLT-F 260
Query: 250 PYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLA---VRHLVYLRFLNLSYNPIS-TIE-- 303
+L + + GL+L L+ H V Y+A R L L+ L+L N IS TIE
Sbjct: 261 NHLSRLDDSSFLGLSL--LNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDM 318
Query: 304 GSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLET 363
L +L+ + L G ++ + AF GL+ L L++S N + +L+ + F + L+
Sbjct: 319 NGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQ 378
Query: 364 LILDSNPLACDCRLLWVFRRRWRLNFNRQ---QPTCATPEFVQGKE-FKDFPDVLLPNYF 419
L L+++ L CDC+L W+ +W N Q +CA P+ ++G+ F PD + + F
Sbjct: 379 LHLNTSSLLCDCQLKWL--PQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDF 436
Query: 420 TCRRARIRDRKAQQVFVDEGHTVQFVCRA--DGDPPPAILWLSPRKHLVSAKSNGRLTVF 477
+ ++ + +G + F+C A D P W + L A+ +
Sbjct: 437 PKPQITVQPETQSAI---KGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLR 493
Query: 478 PDG--------TLEVRYAQVQDNGTYLCIAAN-AGGNDSMPAHLHV 514
G L +R + G Y C+ +N G + S+ A L V
Sbjct: 494 AQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTV 539
Score = 86.7 bits (213), Expect = 6e-17
Identities = 77/302 (25%), Positives = 149/302 (49%), Gaps = 29/302 (9%)
Query: 96 HLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIP-LGVFTGLSNLTKLDISENK 154
H+ +L+ N +S ++ + ++L +LR + L +N L+ IP LG + +N+T L ++ N+
Sbjct: 15 HISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS--ANITLLSLAGNR 72
Query: 155 IVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHL 214
IV +L ++ +L++L++ N++ + AF L L+ L L +TS+ +L
Sbjct: 73 IVEILPEHLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFDNL 130
Query: 215 -HGLIVLRLRHLNINAIRDYSFK-------RLYRLKVLEISHWPY--------------- 251
+ L+VL+L I+AI FK L R K+ + +
Sbjct: 131 ANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNG 190
Query: 252 LDTMTPNCLYGL-NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHEL 310
+ + +GL N+ L + H NLT + + L+ L+ L+LS N I+ I
Sbjct: 191 VTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFC 250
Query: 311 LRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNP 370
+L E+ L L+ ++ +F GL+ L L++ N+++ + + F + +L+TL L +N
Sbjct: 251 QKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNE 310
Query: 371 LA 372
++
Sbjct: 311 IS 312
Score = 73.6 bits (179), Expect = 5e-13
Identities = 118/514 (22%), Positives = 190/514 (36%), Gaps = 77/514 (14%)
Query: 58 HRKRFVAVPEGIPTETRL--LDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAF 115
+R R A+P + +L L+L +N+IK ++ F L+ L++ N V+ + GAF
Sbjct: 140 NRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAF 199
Query: 116 NNLFNLRTLGLRSNRLKLIPLGVFTGL------------------------SNLTKLDIS 151
L N+ L L N L I G GL L++LD++
Sbjct: 200 WGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLT 259
Query: 152 ENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEAL 211
N + L D F L L +L +G+N + YI+ AF GL+SL+ L L+ ++ +
Sbjct: 260 FNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMN 319
Query: 212 SHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLS-- 269
GL LR L N IR + K L LE +LD ++ N + L + S
Sbjct: 320 GAFSGLDKLRRLILQGNRIRSITKKAFTGLDALE-----HLD-LSDNAIMSLQGNAFSQM 373
Query: 270 --ITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVE 327
+ +L L L +L N S + S H L L G + V
Sbjct: 374 KKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQL------LKGRSIFAVS 427
Query: 328 PYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRL 387
P F V + T++ ++ + S + D + + +++ L
Sbjct: 428 PDGF-------VCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNEL 480
Query: 388 NFNRQQPTCATPEFVQGKEFKDFPDVL----------------LPNYF----------TC 421
+ + A QG E ++ +L + N+F T
Sbjct: 481 LHDAEMENYAHLR-AQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTV 539
Query: 422 RRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFP-DG 480
+ + + G + C A G P P I W A R+ V P D
Sbjct: 540 NMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDD 599
Query: 481 TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHV 514
+ +++D G Y C A N+ G+ S A L V
Sbjct: 600 VFFIVDVKIEDIGVYSCTAQNSAGSISANATLTV 633
Score = 32.3 bits (72), Expect = 1.3
Identities = 24/81 (29%), Positives = 32/81 (39%), Gaps = 6/81 (7%)
Query: 436 VDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDGT--LEVRYAQVQDNG 493
V +G T C A G PPP + W LV + + F G L + + V D G
Sbjct: 648 VTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERH----FFAAGNQLLIIVDSDVSDAG 703
Query: 494 TYLCIAANAGGNDSMPAHLHV 514
Y C +N G + L V
Sbjct: 704 KYTCEMSNTLGTERGNVRLSV 724
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 142 bits (359), Expect = 7e-34
Identities = 111/385 (28%), Positives = 174/385 (45%), Gaps = 48/385 (12%)
Query: 28 LLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLN 87
LL+ + A+ CP C C+ V CH A+P+ IP T L+L N I ++
Sbjct: 20 LLLWAAAWRLGASACPALCTCTGT--TVDCHGTGLQAIPKNIPRNTERLELNGNNITRIH 77
Query: 88 QDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTK 147
+++FA L L+L EN + AVE GAF+++ L L L N+L ++P +F L++
Sbjct: 78 KNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSR 137
Query: 148 LDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIP 207
LD+SEN I + F+ +LK+L++ N + I AF L LE LTL N+T+IP
Sbjct: 138 LDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIP 197
Query: 208 TEALSHLHGLIVLRL--RHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNL 265
+ +H+ L RL HL + + + L + + + + P L GLN+
Sbjct: 198 VSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGL----FTQCSGPASLRGLNV 253
Query: 266 T---------------------SLSITHC----------------NLTAVPYLAVRHLVY 288
+LS C LTA+P +
Sbjct: 254 AEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTE 313
Query: 289 LRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLT 348
+R L N I +I +L+ I L Q+A + P AF+GL L L + GN++T
Sbjct: 314 IR---LELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKIT 370
Query: 349 TLEESVFHSVGNLETLILDSNPLAC 373
L VF + L+ L+L++N + C
Sbjct: 371 DLPRGVFGGLYTLQLLLLNANKINC 395
Score = 125 bits (314), Expect = 1e-28
Identities = 121/445 (27%), Positives = 192/445 (43%), Gaps = 76/445 (17%)
Query: 38 SATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHL 97
S+ CP C CS + V C K A+P +P + L N IK++ F+ + L
Sbjct: 278 SSGSCPAMCTCS--NGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKL 335
Query: 98 EELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVI 157
++L+ N ++ + P AF L +L +L L N++ +P GVF GL L L ++ NKI
Sbjct: 336 RRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINC 395
Query: 158 LLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEK------CNLTSI----- 206
+ FQDL NL L + DN + ++ F+ L +++ L L + CNL +
Sbjct: 396 IRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLR 455
Query: 207 --PTEALSHLHGLIVLRLRHLNINAIRDYSF----KRLYRLKVLE---ISHWPYLDTMTP 257
P E S RL + I I+ F K Y + E ++ D + P
Sbjct: 456 TNPIET-SGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCP 514
Query: 258 N-CLYGLNL---TSLSIT-------------HCNLTAVPYLAV----RHLVYLRFLNLSY 296
+ C N+ +SL +T N + L + L +L+ +NLS
Sbjct: 515 HKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSN 574
Query: 297 NPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLR------------------ 338
N +S IE + E+ L QL + FRGL+ LR
Sbjct: 575 NKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFT 634
Query: 339 ------VLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWV---FRRRWRLNF 389
+L++ NQ+TT+ F ++ +L TL L +NP C+C+L W+ R+R +
Sbjct: 635 GLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTG 694
Query: 390 NRQQPTCATPEFVQGKEFKD--FPD 412
N P C P+F++ +D FPD
Sbjct: 695 N---PRCQNPDFLRQIPLQDVAFPD 716
Score = 101 bits (252), Expect = 2e-21
Identities = 106/405 (26%), Positives = 169/405 (41%), Gaps = 56/405 (13%)
Query: 42 CPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDE-FASFPHLEEL 100
CP +C C A V C + +PE IP T L L N I L F HL+++
Sbjct: 513 CPHKCRCEAN--VVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKI 570
Query: 101 ELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLD 160
L+ N VS +E GAF ++ L L +N+L+ I G+F GL L L + N+I + +
Sbjct: 571 NLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHN 630
Query: 161 YMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTL----EKCNLTSIPTEALSHLHG 216
F L N++ L + DN + +S AF L SL L L CN L+ L G
Sbjct: 631 DSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNC------QLAWLGG 684
Query: 217 LIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTM-------TPNCLYGLNL--TS 267
+ R ++ F R L+ + + + P C T
Sbjct: 685 WLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTV 744
Query: 268 LSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVE 327
+ ++ +L A+P +++ L L N + + G L LQ + L +++ +
Sbjct: 745 VRCSNKHLRALPKGIPKNVTE---LYLDGNQFTLVPG-QLSTFKYLQLVDLSNNKISSLS 800
Query: 328 PYAFRGLNYLRVLNVSGNQL------------------------TTLEESVFHSVGNLET 363
+F ++ L L +S N L +TL+E +F V +L
Sbjct: 801 NSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSH 860
Query: 364 LILDSNPLACDCRLLWVFRRRWRLNFNRQQP---TCATPEFVQGK 405
L + +NPL CDC L W+ W + ++P CA P+ ++GK
Sbjct: 861 LAIGANPLYCDCHLRWL--SSW-VKTGYKEPGIARCAGPQDMEGK 902
Score = 78.2 bits (191), Expect = 2e-14
Identities = 52/148 (35%), Positives = 77/148 (52%), Gaps = 5/148 (3%)
Query: 41 GCPPR--C--ECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPH 96
GC PR C EC+ D V C K A+P+GIP L L N+ TL + ++F +
Sbjct: 727 GCLPRPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQF-TLVPGQLSTFKY 785
Query: 97 LEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIV 156
L+ ++L+ N +S++ +F N+ L TL L N L+ IP F GL +L L + N I
Sbjct: 786 LQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDIS 845
Query: 157 ILLDYMFQDLYNLKSLEVGDNDLVYISH 184
L + +F D+ +L L +G N L H
Sbjct: 846 TLQEGIFADVTSLSHLAIGANPLYCDCH 873
Score = 69.7 bits (169), Expect = 8e-12
Identities = 58/192 (30%), Positives = 87/192 (45%), Gaps = 14/192 (7%)
Query: 220 LRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLN-LTSLSITHCNLTAV 278
L L NI I F L +L+VL++ + + + L L + L +
Sbjct: 66 LELNGNNITRIHKNDFAGLKQLRVLQLME-NQIGAVERGAFDDMKELERLRLNRNQLHML 124
Query: 279 PYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLR 338
P L ++ L L+LS N I I L+ +QL Q++ +E AFR L L
Sbjct: 125 PELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLE 184
Query: 339 VLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPT--- 395
VL ++ N +TT+ S F+ + L T L SN L CDC L W+ +W RQ+PT
Sbjct: 185 VLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWL--SQWL----RQRPTIGL 238
Query: 396 ---CATPEFVQG 404
C+ P ++G
Sbjct: 239 FTQCSGPASLRG 250
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 136 bits (342), Expect = 7e-32
Identities = 132/457 (28%), Positives = 211/457 (46%), Gaps = 40/457 (8%)
Query: 75 LLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLF-NLRTLGLRSNRLKL 133
+LDL N I + F P ++EL L N + +E GAF+ L +L TL L NR+
Sbjct: 143 VLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQ 202
Query: 134 IPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSL 193
+P+ F L LT+LD++ N+I ++ FQ L +L+ L++ N++ ++ AF GL+ +
Sbjct: 203 LPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKM 261
Query: 194 EQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAI-----RDYSFKRLYRLKVLEISH 248
L LE +L + + +L +GL L HL+ N+I + +SF + VL ++
Sbjct: 262 HVLHLEYNSLVEVNSGSL---YGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNN 318
Query: 249 WPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS-TIEGSM- 306
LD + L L++ LS H +++ + A + L LR L+L +N IS TIE +
Sbjct: 319 LTRLDEESLAELSSLSVLRLS--HNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSG 376
Query: 307 -LHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLI 365
L L ++ L G ++ V AF GL L LN+ GN + +++ F + NL+ L
Sbjct: 377 AFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELH 436
Query: 366 LDSNPLACDCRLLWVFRRRWRLNFNRQ---QPTCATPEFVQGKEFKDFPDVLLPNYFTC- 421
+ S+ CDC+L W+ W + Q TCA PE ++G+ P P F C
Sbjct: 437 ISSDSFLCDCQLKWL--PPWLIGRMLQAFVTATCAHPESLKGQSIFSVP----PESFVCD 490
Query: 422 ---RRARIRDRKAQQVFVDEGHTVQFVCRA--DGDPPPAILWLSPRKHLVSAKSNGRLTV 476
+ I + V G ++F C A P W + L +A + V
Sbjct: 491 DFLKPQIITQPETTMAMV--GKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHV 548
Query: 477 F-PDG-------TLEVRYAQVQDNGTYLCIAANAGGN 505
DG L +R G Y C+ N G+
Sbjct: 549 HAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGS 585
Score = 40.4 bits (93), Expect = 0.005
Identities = 28/80 (35%), Positives = 36/80 (45%), Gaps = 4/80 (5%)
Query: 436 VDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG-TLEVRYAQVQDNGT 494
V G TV C+A G+PPP I W + L S LT PD L V+ +D G
Sbjct: 704 VSVGETVALQCKATGNPPPRITWFKGDRPL-SLTERHHLT--PDNQLLVVQNVVAEDAGR 760
Query: 495 YLCIAANAGGNDSMPAHLHV 514
Y C +N G + + L V
Sbjct: 761 YTCEMSNTLGTERAHSQLSV 780
Score = 35.8 bits (81), Expect = 0.12
Identities = 23/70 (32%), Positives = 30/70 (42%), Gaps = 1/70 (1%)
Query: 446 CRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDGTLE-VRYAQVQDNGTYLCIAANAGG 504
C A G P P I W A R+ V PD + + ++ D G Y C A N+ G
Sbjct: 620 CAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAG 679
Query: 505 NDSMPAHLHV 514
+ S A L V
Sbjct: 680 SISANATLTV 689
>gi|12007646 nyctalopin precursor [Homo sapiens]
Length = 481
Score = 131 bits (329), Expect = 2e-30
Identities = 120/392 (30%), Positives = 168/392 (42%), Gaps = 40/392 (10%)
Query: 26 ILLLVLGSVLSG---------SATGCPPRCECSAQDR--AVLCHRKRFVAVPEGIPTETR 74
+L+L+L +V+ G A CP C CS +R +V C R + VP +P E
Sbjct: 6 MLVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAV 65
Query: 75 LLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSN-RLKL 133
+DL +N ++ L + F + P L L L N +S + PGAF L L L L N L+
Sbjct: 66 SIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRY 125
Query: 134 IPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSL 193
+ F LS L +LD++ ++ + + + +L L+ L DN + R L L
Sbjct: 126 LHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDN----LFRRVPGALRGL 181
Query: 194 EQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLD 253
LT I A S L GL LR L N +R VLE
Sbjct: 182 ANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLE-------- 233
Query: 254 TMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRL 313
+ L NL L +P A R L LR LNL N + + + +L L
Sbjct: 234 ----HLLLNDNL---------LAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAEL 280
Query: 314 QEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLAC 373
+ + L +A VE AF+ L+ L L+++GN+LT L F L L L NP C
Sbjct: 281 ELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCC 340
Query: 374 DCRLLWVFRRRWRLNFNR-QQPTCATPEFVQG 404
DCRL W+ R W R CA+P V G
Sbjct: 341 DCRLEWL--RDWMEGSGRVTDVPCASPGSVAG 370
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 130 bits (327), Expect = 4e-30
Identities = 107/398 (26%), Positives = 174/398 (43%), Gaps = 59/398 (14%)
Query: 26 ILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKT 85
+LLL+ +L GC C+ R + C ++P+ P T L L N I
Sbjct: 21 LLLLLHKEIL-----GCSSVCQLCT-GRQINCRNLGLSSIPKNFPESTVFLYLTGNNISY 74
Query: 86 LNQDE------------------------FASFPHLEELELNENIVSAVEPGAFNNLFNL 121
+N+ E F HL L LN N + ++PG F L NL
Sbjct: 75 INESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNL 134
Query: 122 RTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVY 181
R L L+ N++ +P GVF L ++ L++ N++ +L F + L+ L++ +N+++
Sbjct: 135 RNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILR 194
Query: 182 ISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRL 241
IS F L +L L L NLT +P+ A L L L L H I AI+ ++FK L L
Sbjct: 195 ISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANL 254
Query: 242 KVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIST 301
+ L + + + +T + G+N ++HL+ LS+N +
Sbjct: 255 EYLLLKN-SRIRNVTRDGFSGIN-----------------NLKHLI------LSHNDLEN 290
Query: 302 IEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLN-YLRVLNVSGNQLTTLEESVFHSVGN 360
+ L L ++L ++ ++ F + L++LN+S N LT L V + +
Sbjct: 291 LNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSS 350
Query: 361 LETLILDSNPLACDCRLL----WVFRRRWRLNFNRQQP 394
L L +SNP C+C+LL W+ LN Q P
Sbjct: 351 LIHLQANSNPWECNCKLLGLRDWLASSAITLNIYCQNP 388
>gi|31542244 leucine rich repeat and fibronectin type III domain
containing 5 [Homo sapiens]
Length = 719
Score = 130 bits (326), Expect = 5e-30
Identities = 127/505 (25%), Positives = 195/505 (38%), Gaps = 126/505 (24%)
Query: 42 CPPRCECS--AQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEE 99
CP RC C + + A LC +K + VP I T E
Sbjct: 20 CPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRT------------------------VE 55
Query: 100 LELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILL 159
L L +N V+ ++ F N+ ++L L +S N I +
Sbjct: 56 LRLADNFVTNIKRKDFANM------------------------TSLVDLTLSRNTISFIT 91
Query: 160 DYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIV 219
+ F DL NL++L + N L I++ FSGL++L L L LT I + A + L
Sbjct: 92 PHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEE 151
Query: 220 LRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVP 279
L L + N LE W ++ M ++L +LS+ H + +P
Sbjct: 152 LDLSYNN-----------------LETIPWDAVEKM-------VSLHTLSLDHNMIDNIP 187
Query: 280 YLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRV 339
HL + L+++ N + + L + R Q + G ++ P F
Sbjct: 188 KGTFSHLHKMTRLDVTSNKLQKLPPDPLFQ--RAQVLATSG----IISPSTF-------- 233
Query: 340 LNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATP 399
L NPL C+C LLW+ RL+ TCA+P
Sbjct: 234 -----------------------ALSFGGNPLHCNCELLWL----RRLSREDDLETCASP 266
Query: 400 EFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWL 459
+ G+ F P+ F C I R ++ V EG C+A GDP PAI W+
Sbjct: 267 PLLTGRYFWSIPE----EEFLCEPPLI-TRHTHEMRVLEGQRATLRCKARGDPEPAIHWI 321
Query: 460 SPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSP 519
SP L+S + R V+ +GTL++ V+D G + CIA+N G + LH+
Sbjct: 322 SPEGKLISNAT--RSLVYDNGTLDILITTVKDTGAFTCIASNPAGEATQIVDLHIIKL-- 377
Query: 520 DWPHQPNKTFAFISNQPGEGEANST 544
PH N T PG + +++
Sbjct: 378 --PHLLNSTNHIHEPDPGSSDISTS 400
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 129 bits (325), Expect = 6e-30
Identities = 112/366 (30%), Positives = 165/366 (45%), Gaps = 32/366 (8%)
Query: 37 GSATG--CPPRCECSAQDRA----VLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDE 90
G A G CP C CS D A V C + +P+G+P T+ L L N + ++
Sbjct: 72 GEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAA 131
Query: 91 FASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDI 150
F + L L L + ++EP A L NL L L N+L+ + LG F L L +
Sbjct: 132 FQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGL 191
Query: 151 SENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEA 210
S N++ L D +F+ L +L L +G N L + AF GL SL +L L L +
Sbjct: 192 SNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPAL 251
Query: 211 LSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLN-LTSLS 269
S L L L L + AI+ F +L RL+ L + + + P GL L L
Sbjct: 252 FSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDR-NLIAAVAPGAFLGLKALRWLD 310
Query: 270 ITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQL----------- 318
++H + + L+ LR L LS+N I+++ +L L+E+QL
Sbjct: 311 LSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAER 370
Query: 319 ----VG---------GQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLI 365
+G QL V+ AF GL + V+N+SGN L L E VF +G L +L
Sbjct: 371 SFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLH 430
Query: 366 LDSNPL 371
L+ + L
Sbjct: 431 LEGSCL 436
Score = 119 bits (297), Expect = 1e-26
Identities = 103/357 (28%), Positives = 157/357 (43%), Gaps = 37/357 (10%)
Query: 72 ETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRL 131
E R LDL +N ++ + + F P L++L L+ N+++AV PGAF L LR L L NR+
Sbjct: 257 ELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRV 316
Query: 132 KLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLN 191
+ F GL L L +S N I L F+DL+ L+ L++G N + ++ R+F GL
Sbjct: 317 AGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLG 376
Query: 192 SLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPY 251
LE LTL+ L + A L + V+ L + + + F+ L +L L +
Sbjct: 377 QLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHL-EGSC 435
Query: 252 LDTMTPNCLYGLN-------------------------LTSLSITHCNLTAVPYLAVRHL 286
L + P+ GL+ L L +T LT +P+ + L
Sbjct: 436 LGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGL 495
Query: 287 VYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQ 346
L +L LS N ++ + L L R + + +L + L LR L++ N
Sbjct: 496 GKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNS 555
Query: 347 LTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQ 403
L T LE L L+ NP C C L + +F Q P+ A P FVQ
Sbjct: 556 LRTFTP----QPPGLERLWLEGNPWDCGCPL------KALRDFALQNPS-AVPRFVQ 601
Score = 117 bits (293), Expect = 3e-26
Identities = 95/322 (29%), Positives = 146/322 (45%), Gaps = 26/322 (8%)
Query: 76 LDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIP 135
L L NR+ L F L +L L N ++ + AF L +LR L L NRL +
Sbjct: 189 LGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQ 248
Query: 136 LGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQ 195
+F+GL+ L +LD+S N + + +F L L+ L + N + ++ AF GL +L
Sbjct: 249 PALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRW 308
Query: 196 LTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTM 255
L L + + + L GL VLRL H I ++R +FK L+ L+ L++ H + +
Sbjct: 309 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGH-NRIRQL 367
Query: 256 TPNCLYGL-NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQ 314
GL L L++ H L V A L + +NLS N + + + L +L
Sbjct: 368 AERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLH 427
Query: 315 EIQLVGGQLAVVEPYAFRGLNYLR------------------------VLNVSGNQLTTL 350
+ L G L + P+ F GL+ LR L+++ NQLT L
Sbjct: 428 SLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHL 487
Query: 351 EESVFHSVGNLETLILDSNPLA 372
+F +G LE L+L N LA
Sbjct: 488 PHRLFQGLGKLEYLLLSRNRLA 509
Score = 63.9 bits (154), Expect = 4e-10
Identities = 59/203 (29%), Positives = 94/203 (46%), Gaps = 24/203 (11%)
Query: 170 KSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINA 229
++L + N+L + AF L+SL L L+ L S+ +AL L L L HL N
Sbjct: 115 QALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHL---HLERNQ 171
Query: 230 IRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYL 289
+R L + +H P L SL +++ L+ + L L
Sbjct: 172 LRS--------LALGTFAHTPAL-------------ASLGLSNNRLSRLEDGLFEGLGSL 210
Query: 290 RFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTT 349
LNL +N ++ + + L L+E+ L G +LA ++P F GL LR L++S N L
Sbjct: 211 WDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRA 270
Query: 350 LEESVFHSVGNLETLILDSNPLA 372
++ +VF + L+ L LD N +A
Sbjct: 271 IKANVFVQLPRLQKLYLDRNLIA 293
Score = 63.5 bits (153), Expect = 5e-10
Identities = 50/187 (26%), Positives = 77/187 (41%), Gaps = 25/187 (13%)
Query: 71 TETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNR 130
T +++L N ++ L + F L L L + + + P F L LR L L+ N
Sbjct: 400 TNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNG 459
Query: 131 LKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGL 190
L I GL+ L +LD++ N+ L ++ HR F GL
Sbjct: 460 LVGIEEQSLWGLAELLELDLTSNQ------------------------LTHLPHRLFQGL 495
Query: 191 NSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWP 250
LE L L + L +P +AL L L + H + A+ + L RL+ L + +
Sbjct: 496 GKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRN-N 554
Query: 251 YLDTMTP 257
L T TP
Sbjct: 555 SLRTFTP 561
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 129 bits (325), Expect = 6e-30
Identities = 112/366 (30%), Positives = 165/366 (45%), Gaps = 32/366 (8%)
Query: 37 GSATG--CPPRCECSAQDRA----VLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDE 90
G A G CP C CS D A V C + +P+G+P T+ L L N + ++
Sbjct: 34 GEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAA 93
Query: 91 FASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDI 150
F + L L L + ++EP A L NL L L N+L+ + LG F L L +
Sbjct: 94 FQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGL 153
Query: 151 SENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEA 210
S N++ L D +F+ L +L L +G N L + AF GL SL +L L L +
Sbjct: 154 SNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPAL 213
Query: 211 LSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLN-LTSLS 269
S L L L L + AI+ F +L RL+ L + + + P GL L L
Sbjct: 214 FSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDR-NLIAAVAPGAFLGLKALRWLD 272
Query: 270 ITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQL----------- 318
++H + + L+ LR L LS+N I+++ +L L+E+QL
Sbjct: 273 LSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAER 332
Query: 319 ----VG---------GQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLI 365
+G QL V+ AF GL + V+N+SGN L L E VF +G L +L
Sbjct: 333 SFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLH 392
Query: 366 LDSNPL 371
L+ + L
Sbjct: 393 LEGSCL 398
Score = 119 bits (297), Expect = 1e-26
Identities = 103/357 (28%), Positives = 157/357 (43%), Gaps = 37/357 (10%)
Query: 72 ETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRL 131
E R LDL +N ++ + + F P L++L L+ N+++AV PGAF L LR L L NR+
Sbjct: 219 ELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRV 278
Query: 132 KLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLN 191
+ F GL L L +S N I L F+DL+ L+ L++G N + ++ R+F GL
Sbjct: 279 AGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLG 338
Query: 192 SLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPY 251
LE LTL+ L + A L + V+ L + + + F+ L +L L +
Sbjct: 339 QLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHL-EGSC 397
Query: 252 LDTMTPNCLYGLN-------------------------LTSLSITHCNLTAVPYLAVRHL 286
L + P+ GL+ L L +T LT +P+ + L
Sbjct: 398 LGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGL 457
Query: 287 VYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQ 346
L +L LS N ++ + L L R + + +L + L LR L++ N
Sbjct: 458 GKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNS 517
Query: 347 LTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQ 403
L T LE L L+ NP C C L + +F Q P+ A P FVQ
Sbjct: 518 LRTFTP----QPPGLERLWLEGNPWDCGCPL------KALRDFALQNPS-AVPRFVQ 563
Score = 117 bits (293), Expect = 3e-26
Identities = 95/322 (29%), Positives = 146/322 (45%), Gaps = 26/322 (8%)
Query: 76 LDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIP 135
L L NR+ L F L +L L N ++ + AF L +LR L L NRL +
Sbjct: 151 LGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQ 210
Query: 136 LGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQ 195
+F+GL+ L +LD+S N + + +F L L+ L + N + ++ AF GL +L
Sbjct: 211 PALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRW 270
Query: 196 LTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTM 255
L L + + + L GL VLRL H I ++R +FK L+ L+ L++ H + +
Sbjct: 271 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGH-NRIRQL 329
Query: 256 TPNCLYGL-NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQ 314
GL L L++ H L V A L + +NLS N + + + L +L
Sbjct: 330 AERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLH 389
Query: 315 EIQLVGGQLAVVEPYAFRGLNYLR------------------------VLNVSGNQLTTL 350
+ L G L + P+ F GL+ LR L+++ NQLT L
Sbjct: 390 SLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHL 449
Query: 351 EESVFHSVGNLETLILDSNPLA 372
+F +G LE L+L N LA
Sbjct: 450 PHRLFQGLGKLEYLLLSRNRLA 471
Score = 63.9 bits (154), Expect = 4e-10
Identities = 59/203 (29%), Positives = 94/203 (46%), Gaps = 24/203 (11%)
Query: 170 KSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINA 229
++L + N+L + AF L+SL L L+ L S+ +AL L L L HL N
Sbjct: 77 QALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHL---HLERNQ 133
Query: 230 IRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYL 289
+R L + +H P L SL +++ L+ + L L
Sbjct: 134 LRS--------LALGTFAHTPAL-------------ASLGLSNNRLSRLEDGLFEGLGSL 172
Query: 290 RFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTT 349
LNL +N ++ + + L L+E+ L G +LA ++P F GL LR L++S N L
Sbjct: 173 WDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRA 232
Query: 350 LEESVFHSVGNLETLILDSNPLA 372
++ +VF + L+ L LD N +A
Sbjct: 233 IKANVFVQLPRLQKLYLDRNLIA 255
Score = 63.5 bits (153), Expect = 5e-10
Identities = 50/187 (26%), Positives = 77/187 (41%), Gaps = 25/187 (13%)
Query: 71 TETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNR 130
T +++L N ++ L + F L L L + + + P F L LR L L+ N
Sbjct: 362 TNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNG 421
Query: 131 LKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGL 190
L I GL+ L +LD++ N+ L ++ HR F GL
Sbjct: 422 LVGIEEQSLWGLAELLELDLTSNQ------------------------LTHLPHRLFQGL 457
Query: 191 NSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWP 250
LE L L + L +P +AL L L + H + A+ + L RL+ L + +
Sbjct: 458 GKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRN-N 516
Query: 251 YLDTMTP 257
L T TP
Sbjct: 517 SLRTFTP 523
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 127 bits (320), Expect = 2e-29
Identities = 105/349 (30%), Positives = 166/349 (47%), Gaps = 6/349 (1%)
Query: 26 ILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTE-TRLLDLGKNRIK 84
+L VLG +L CPP C+C +D A G+PT T +L G R
Sbjct: 6 LLCAVLG-LLRAQPFPCPPACKCVFRDAAQCSGGDVARISALGLPTNLTHILLFGMGR-G 63
Query: 85 TLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSN 144
L F+ L+ L ++++ +SAV PG F++L L+TL L N++ +P + +
Sbjct: 64 VLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVL 123
Query: 145 LTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLT 204
L +L + N + + MFQ L NL+ L + N L ++ F+ L +L+ L L NLT
Sbjct: 124 LEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLT 183
Query: 205 SIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGL- 263
+P L L L L + ++ L L L+ H ++ ++ P L
Sbjct: 184 HLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQF-HRNHIRSIAPGAFDRLP 242
Query: 264 NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQL 323
NL+SL+++ +L +P H L L L NP++ + G + E+ LQE+ L QL
Sbjct: 243 NLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQL 302
Query: 324 AVVEPYAFRGLNYLRVLNVS-GNQLTTLEESVFHSVGNLETLILDSNPL 371
+ AFR L+ LR L V+ +L+ L + F +G L+ L L SN L
Sbjct: 303 RTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGL 351
Score = 113 bits (283), Expect = 5e-25
Identities = 97/349 (27%), Positives = 162/349 (46%), Gaps = 9/349 (2%)
Query: 59 RKRFVAVPEGIPTETRLLD---LGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAF 115
R + +P + + LL+ L N ++ ++Q+ F +L+EL LN+N + + F
Sbjct: 107 RNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLF 166
Query: 116 NNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVG 175
NL NL+ L L N L +P G+ + L +L + N++V L + L L L+
Sbjct: 167 TNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFH 226
Query: 176 DNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSF 235
N + I+ AF L +L LTL + +L +P+ H H L +L L + + F
Sbjct: 227 RNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLF 286
Query: 236 KRLYRLKVLEISHWPYLDTMTPNCLYGLN-LTSLSIT-HCNLTAVPYLAVRHLVYLRFLN 293
+ L+ L ++ L T+ L+ L L +T L+A+P A + L L+ L
Sbjct: 287 GEMGGLQELWLNR-TQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLA 345
Query: 294 LSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEES 353
L N ++ + +L L +L+++ L +L + FR L+ L + + NQL TL
Sbjct: 346 LHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGD 405
Query: 354 VFHSVGNLETLILDSNPLACDCRL---LWVFRRRWRLNFNRQQPTCATP 399
VF ++ L ++L N CDC L L R+ L + P CA P
Sbjct: 406 VFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAGP 454
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 126 bits (317), Expect = 5e-29
Identities = 96/334 (28%), Positives = 155/334 (46%), Gaps = 5/334 (1%)
Query: 41 GCPPRCECSAQDRAVL---CHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHL 97
GCP C C R +L C +P + T LDL N I L + S L
Sbjct: 33 GCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFL 92
Query: 98 EELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVI 157
EEL L N ++ + GAF L++L+ L L++N+L+ +P L +L L + N I
Sbjct: 93 EELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISY 152
Query: 158 LLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGL 217
+ F L++L+ L + DN L I +AF L++L+ +TL + IP A +L L
Sbjct: 153 VPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSL 212
Query: 218 IVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTA 277
+VL L + I+++ F L+ L+ L++ ++ LD NL L N+ +
Sbjct: 213 VVLHLHNNRIHSLGKKCFDGLHSLETLDL-NYNNLDEFPTAIRTLSNLKELGFHSNNIRS 271
Query: 278 VPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYL 337
+P A L ++ NPI + S L L+ + L G + E G L
Sbjct: 272 IPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTL-NGASQITEFPDLTGTANL 330
Query: 338 RVLNVSGNQLTTLEESVFHSVGNLETLILDSNPL 371
L ++G Q+++L ++V + + NL+ L L N L
Sbjct: 331 ESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLL 364
Score = 59.7 bits (143), Expect = 8e-09
Identities = 58/176 (32%), Positives = 85/176 (48%), Gaps = 17/176 (9%)
Query: 82 RIKTLN-QDEFASFP------HLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLI 134
R TLN + FP +LE L L +S++ N L NL+ L L N L+ +
Sbjct: 308 RTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDL 367
Query: 135 PLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLE 194
P F+ L K+D+ N+I + FQ L +L+SL + N + I AFS L SL
Sbjct: 368 PS--FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLI 425
Query: 195 QLTLEKCNLTSIPTEALSHLHGLIVLRL--RHLNINAIRDYSFKRLYRLKVLEISH 248
+L L L+S P ++ LHGL L+L H + I +F LKV+E+ +
Sbjct: 426 KLDLSSNLLSSFP---ITGLHGLTHLKLTGNHALQSLISSENFP---ELKVIEMPY 475
Score = 50.1 bits (118), Expect = 6e-06
Identities = 29/86 (33%), Positives = 49/86 (56%)
Query: 287 VYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQ 346
V+ +L+LS N IS + + L L L+E++L G L + AF GL L+VL + NQ
Sbjct: 66 VFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQ 125
Query: 347 LTTLEESVFHSVGNLETLILDSNPLA 372
L + ++ +L++L LD+N ++
Sbjct: 126 LRHVPTEALQNLRSLQSLRLDANHIS 151
Score = 43.1 bits (100), Expect = 8e-04
Identities = 28/78 (35%), Positives = 38/78 (48%), Gaps = 3/78 (3%)
Query: 76 LDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIP 135
+DL N I + D F L L L N ++ + P AF+ L +L L L SN L P
Sbjct: 379 IDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFP 438
Query: 136 LGVFTGLSNLTKLDISEN 153
+ TGL LT L ++ N
Sbjct: 439 I---TGLHGLTHLKLTGN 453
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.139 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,700,208
Number of Sequences: 37866
Number of extensions: 1069462
Number of successful extensions: 6768
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 309
Number of HSP's successfully gapped in prelim test: 199
Number of HSP's that attempted gapping in prelim test: 2585
Number of HSP's gapped (non-prelim): 2367
length of query: 620
length of database: 18,247,518
effective HSP length: 108
effective length of query: 512
effective length of database: 14,157,990
effective search space: 7248890880
effective search space used: 7248890880
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.