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Search of human proteins with 4885105
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4885105 chromatin assembly factor 1 subunit B [Homo sapiens]
(559 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4885105 chromatin assembly factor 1 subunit B [Homo sapiens] 1136 0.0
gi|21536485 HIR histone cell cycle regulation defective homolog ... 148 1e-35
gi|16554629 WD repeat domain 5 [Homo sapiens] 87 5e-17
gi|16554627 WD repeat domain 5 [Homo sapiens] 87 5e-17
gi|4757988 WD repeat domain 39 [Homo sapiens] 84 3e-16
gi|23199987 WD repeat domain 5B [Homo sapiens] 79 1e-14
gi|62234438 Notchless gene homolog isoform b [Homo sapiens] 75 2e-13
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 75 2e-13
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 74 4e-13
gi|8923881 WD SOCS-box protein 2 [Homo sapiens] 70 4e-12
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 70 7e-12
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 70 7e-12
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 70 7e-12
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 69 9e-12
gi|32189425 WD repeat domain 69 [Homo sapiens] 69 9e-12
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 69 9e-12
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 69 9e-12
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 69 9e-12
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 69 9e-12
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 69 9e-12
gi|21071067 TBP-associated factor 5 [Homo sapiens] 69 1e-11
gi|19913367 transducin beta-like 1Y [Homo sapiens] 69 1e-11
gi|19913365 transducin beta-like 1Y [Homo sapiens] 69 1e-11
gi|15150805 transducin beta-like 1Y [Homo sapiens] 69 1e-11
gi|26665869 WD repeat domain 51B [Homo sapiens] 68 3e-11
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 67 3e-11
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 67 4e-11
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 67 6e-11
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [... 65 1e-10
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 65 1e-10
>gi|4885105 chromatin assembly factor 1 subunit B [Homo sapiens]
Length = 559
Score = 1136 bits (2939), Expect = 0.0
Identities = 559/559 (100%), Positives = 559/559 (100%)
Query: 1 MKVITCEIAWHNKEPVYSLDFQHGTAGRIHRLASAGVDTNVRIWKVEKGPDGKAIVEFLS 60
MKVITCEIAWHNKEPVYSLDFQHGTAGRIHRLASAGVDTNVRIWKVEKGPDGKAIVEFLS
Sbjct: 1 MKVITCEIAWHNKEPVYSLDFQHGTAGRIHRLASAGVDTNVRIWKVEKGPDGKAIVEFLS 60
Query: 61 NLARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWT 120
NLARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWT
Sbjct: 61 NLARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWT 120
Query: 121 VVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWD 180
VVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWD
Sbjct: 121 VVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWD 180
Query: 181 PLGQYVATLSCDRVLRVYSIQKKRVAFNVSKMLSGIGAEGEARSYRMFHDDSMKSFFRRL 240
PLGQYVATLSCDRVLRVYSIQKKRVAFNVSKMLSGIGAEGEARSYRMFHDDSMKSFFRRL
Sbjct: 181 PLGQYVATLSCDRVLRVYSIQKKRVAFNVSKMLSGIGAEGEARSYRMFHDDSMKSFFRRL 240
Query: 241 SFTPDGSLLLTPAGCVESGENVMNTTYVFSRKNLKRPIAHLPCPGKATLAVRCCPVYFEL 300
SFTPDGSLLLTPAGCVESGENVMNTTYVFSRKNLKRPIAHLPCPGKATLAVRCCPVYFEL
Sbjct: 241 SFTPDGSLLLTPAGCVESGENVMNTTYVFSRKNLKRPIAHLPCPGKATLAVRCCPVYFEL 300
Query: 301 RPVVETGVELMSLPYRLVFAVASEDSVLLYDTQQSFPFGYVSNIHYHTLSDISWSSDGAF 360
RPVVETGVELMSLPYRLVFAVASEDSVLLYDTQQSFPFGYVSNIHYHTLSDISWSSDGAF
Sbjct: 301 RPVVETGVELMSLPYRLVFAVASEDSVLLYDTQQSFPFGYVSNIHYHTLSDISWSSDGAF 360
Query: 361 LAISSTDGYCSFVTFEKDELGIPLKEKPVLNMRTPDTAKKTKSQTHRGSSPGPRPVEGTP 420
LAISSTDGYCSFVTFEKDELGIPLKEKPVLNMRTPDTAKKTKSQTHRGSSPGPRPVEGTP
Sbjct: 361 LAISSTDGYCSFVTFEKDELGIPLKEKPVLNMRTPDTAKKTKSQTHRGSSPGPRPVEGTP 420
Query: 421 ASRTQDPSSPGTTPPQARQAPAPTVIRDPPSITPAVKSPLPGPSEEKTLQPSSQNTKAHP 480
ASRTQDPSSPGTTPPQARQAPAPTVIRDPPSITPAVKSPLPGPSEEKTLQPSSQNTKAHP
Sbjct: 421 ASRTQDPSSPGTTPPQARQAPAPTVIRDPPSITPAVKSPLPGPSEEKTLQPSSQNTKAHP 480
Query: 481 SRRVTLNTLQAWSKTTPRRINLTPLKTDTPPSSVPTSVISTPSTEEIQSETPGDAQGSPP 540
SRRVTLNTLQAWSKTTPRRINLTPLKTDTPPSSVPTSVISTPSTEEIQSETPGDAQGSPP
Sbjct: 481 SRRVTLNTLQAWSKTTPRRINLTPLKTDTPPSSVPTSVISTPSTEEIQSETPGDAQGSPP 540
Query: 541 ELKRPRLDENKGGTESLDP 559
ELKRPRLDENKGGTESLDP
Sbjct: 541 ELKRPRLDENKGGTESLDP 559
>gi|21536485 HIR histone cell cycle regulation defective homolog A
[Homo sapiens]
Length = 1017
Score = 148 bits (373), Expect = 1e-35
Identities = 113/394 (28%), Positives = 182/394 (46%), Gaps = 32/394 (8%)
Query: 1 MKVITCEIAWHNKEPVYSLDFQHGTAGRIHRLASAGVDTN-VRIWKV-----EKGPDGKA 54
MK++ HN +P++S+D G G D+ V IW + E +
Sbjct: 1 MKLLKPTWVNHNGKPIFSVDIHPD--GTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDEN 58
Query: 55 IVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQL 114
I + L + H VN VR+S +G LASGGDD +I++WK P + A
Sbjct: 59 IPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLA-- 116
Query: 115 NKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKI-SIFNEHKSY 173
N E W V LR H DV D+ W+ +AS SVDNT +IW+ K +I + H
Sbjct: 117 NVEQWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGL 176
Query: 174 VQGVTWDPLGQYVATLSCDRVLRVYSIQKKRVAFNVSKMLSGIGAEGEARSYRMFHDDSM 233
V+G+TWDP+G+Y+A+ + DR L+V+ ++ +++K G
Sbjct: 177 VKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGG--------------- 221
Query: 234 KSFFRRLSFTPDGSLLLTPAGCVESGENVMNTTYVFSRKNLKRPIAHLPCPGKATLAVRC 293
+ RLS++PDG L++ SG T + R+ K + + KA V+
Sbjct: 222 TTHVLRLSWSPDGHYLVSAHAMNNSGP----TAQIIEREGWKTNMDFVG-HRKAVTVVKF 276
Query: 294 CPVYFELRPVVETGVELMSLPYRLVFAVASEDSVLLYDTQQSFPFGYVSNIHYHTLSDIS 353
P F+ + + + S PY + + S+ ++ T P + + ++ DIS
Sbjct: 277 NPKIFKKKQKNGSSAK-PSCPYCCCAVGSKDRSLSVWLTCLKRPLVVIHELFDKSIMDIS 335
Query: 354 WSSDGAFLAISSTDGYCSFVTFEKDELGIPLKEK 387
W+ +G + + S DG +F+ F +DELG PL E+
Sbjct: 336 WTLNGLGILVCSMDGSVAFLDFSQDELGDPLSEE 369
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 86.7 bits (213), Expect = 5e-17
Identities = 48/140 (34%), Positives = 70/140 (50%), Gaps = 21/140 (15%)
Query: 62 LARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTV 121
LA HTKAV+ V+FSP GE LAS D +I +W D K
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK---------------------F 79
Query: 122 VKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDP 181
KT+ GH + D+ W++D NL+ SAS D T IWDVS G+ + H +YV ++P
Sbjct: 80 EKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP 139
Query: 182 LGQYVATLSCDRVLRVYSIQ 201
+ + S D +R++ ++
Sbjct: 140 QSNLIVSGSFDESVRIWDVK 159
Score = 65.5 bits (158), Expect = 1e-10
Identities = 44/172 (25%), Positives = 73/172 (42%), Gaps = 29/172 (16%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
L SA D ++IW V G + L L H+ V F+P ++ SG D +
Sbjct: 102 LVSASDDKTLKIWDVSSG-------KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154
Query: 92 LWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDN 151
+W V K +KTL H + V + + DG+L+ S+S D
Sbjct: 155 IWDVKTGK---------------------CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDG 193
Query: 152 TAIIWDVSKGQKI-SIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQK 202
IWD + GQ + ++ ++ V V + P G+Y+ + D L+++ K
Sbjct: 194 LCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245
Score = 61.2 bits (147), Expect = 2e-09
Identities = 41/167 (24%), Positives = 69/167 (41%), Gaps = 28/167 (16%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
LAS+ D ++IW G +F ++ H ++ V +S +L S DD +
Sbjct: 60 LASSSADKLIKIWGAYDG-------KFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLK 112
Query: 92 LWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDN 151
+W V+ K +KTL+GH V+ + NL+ S S D
Sbjct: 113 IWDVSSGK---------------------CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 151
Query: 152 TAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVY 198
+ IWDV G+ + H V V ++ G + + S D + R++
Sbjct: 152 SVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Score = 45.1 bits (105), Expect = 2e-04
Identities = 22/85 (25%), Positives = 41/85 (48%)
Query: 116 KENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQ 175
K N+ + TL GH + V + ++ +G +AS+S D IW G+ + HK +
Sbjct: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGIS 91
Query: 176 GVTWDPLGQYVATLSCDRVLRVYSI 200
V W + + S D+ L+++ +
Sbjct: 92 DVAWSSDSNLLVSASDDKTLKIWDV 116
Score = 45.1 bits (105), Expect = 2e-04
Identities = 42/194 (21%), Positives = 71/194 (36%), Gaps = 34/194 (17%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
+ S D +VRIW V+ G + L L H+ V+ V F+ G ++ S D +
Sbjct: 144 IVSGSFDESVRIWDVKTG-------KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 196
Query: 92 LWKV-----------NDNKEPEQIAFQDEDEAQL-----------NKENWTVVKTLRGHL 129
+W +DN + F + L + +KT GH
Sbjct: 197 IWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK 256
Query: 130 EDVYDICW---ATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYV 186
+ Y I T G + S S DN IW++ + + H V P +
Sbjct: 257 NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENII 316
Query: 187 AT--LSCDRVLRVY 198
A+ L D+ ++++
Sbjct: 317 ASAALENDKTIKLW 330
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 86.7 bits (213), Expect = 5e-17
Identities = 48/140 (34%), Positives = 70/140 (50%), Gaps = 21/140 (15%)
Query: 62 LARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTV 121
LA HTKAV+ V+FSP GE LAS D +I +W D K
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK---------------------F 79
Query: 122 VKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDP 181
KT+ GH + D+ W++D NL+ SAS D T IWDVS G+ + H +YV ++P
Sbjct: 80 EKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP 139
Query: 182 LGQYVATLSCDRVLRVYSIQ 201
+ + S D +R++ ++
Sbjct: 140 QSNLIVSGSFDESVRIWDVK 159
Score = 65.5 bits (158), Expect = 1e-10
Identities = 44/172 (25%), Positives = 73/172 (42%), Gaps = 29/172 (16%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
L SA D ++IW V G + L L H+ V F+P ++ SG D +
Sbjct: 102 LVSASDDKTLKIWDVSSG-------KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154
Query: 92 LWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDN 151
+W V K +KTL H + V + + DG+L+ S+S D
Sbjct: 155 IWDVKTGK---------------------CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDG 193
Query: 152 TAIIWDVSKGQKI-SIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQK 202
IWD + GQ + ++ ++ V V + P G+Y+ + D L+++ K
Sbjct: 194 LCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245
Score = 61.2 bits (147), Expect = 2e-09
Identities = 41/167 (24%), Positives = 69/167 (41%), Gaps = 28/167 (16%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
LAS+ D ++IW G +F ++ H ++ V +S +L S DD +
Sbjct: 60 LASSSADKLIKIWGAYDG-------KFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLK 112
Query: 92 LWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDN 151
+W V+ K +KTL+GH V+ + NL+ S S D
Sbjct: 113 IWDVSSGK---------------------CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 151
Query: 152 TAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVY 198
+ IWDV G+ + H V V ++ G + + S D + R++
Sbjct: 152 SVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Score = 45.1 bits (105), Expect = 2e-04
Identities = 22/85 (25%), Positives = 41/85 (48%)
Query: 116 KENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQ 175
K N+ + TL GH + V + ++ +G +AS+S D IW G+ + HK +
Sbjct: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGIS 91
Query: 176 GVTWDPLGQYVATLSCDRVLRVYSI 200
V W + + S D+ L+++ +
Sbjct: 92 DVAWSSDSNLLVSASDDKTLKIWDV 116
Score = 45.1 bits (105), Expect = 2e-04
Identities = 42/194 (21%), Positives = 71/194 (36%), Gaps = 34/194 (17%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
+ S D +VRIW V+ G + L L H+ V+ V F+ G ++ S D +
Sbjct: 144 IVSGSFDESVRIWDVKTG-------KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 196
Query: 92 LWKV-----------NDNKEPEQIAFQDEDEAQL-----------NKENWTVVKTLRGHL 129
+W +DN + F + L + +KT GH
Sbjct: 197 IWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK 256
Query: 130 EDVYDICW---ATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYV 186
+ Y I T G + S S DN IW++ + + H V P +
Sbjct: 257 NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENII 316
Query: 187 AT--LSCDRVLRVY 198
A+ L D+ ++++
Sbjct: 317 ASAALENDKTIKLW 330
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 84.0 bits (206), Expect = 3e-16
Identities = 56/170 (32%), Positives = 79/170 (46%), Gaps = 26/170 (15%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
LAS G D +RIW E D LS H + V V +SP G LAS DA
Sbjct: 31 LASCGGDRRIRIWGTEG--DSWICKSVLSE--GHQRTVRKVAWSPCGNYLASASFDATTC 86
Query: 92 LWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDN 151
+WK N QD+ E V TL GH +V + WA GNL+A+ S D
Sbjct: 87 IWKKN----------QDDFEC---------VTTLEGHENEVKSVAWAPSGNLLATCSRDK 127
Query: 152 TAIIWDVSKGQK---ISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVY 198
+ +W+V + + +S+ N H V+ V W P + +A+ S D +++Y
Sbjct: 128 SVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLY 177
Score = 57.0 bits (136), Expect = 4e-08
Identities = 36/133 (27%), Positives = 60/133 (45%), Gaps = 22/133 (16%)
Query: 74 FSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTL-RGHLEDV 132
++P G +LAS G D I +W ++W L GH V
Sbjct: 24 WNPAGTLLASCGGDRRIRIWGTEG-------------------DSWICKSVLSEGHQRTV 64
Query: 133 YDICWATDGNLMASASVDNTAIIWDVSKG--QKISIFNEHKSYVQGVTWDPLGQYVATLS 190
+ W+ GN +ASAS D T IW ++ + ++ H++ V+ V W P G +AT S
Sbjct: 65 RKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCS 124
Query: 191 CDRVLRVYSIQKK 203
D+ + V+ + ++
Sbjct: 125 RDKSVWVWEVDEE 137
Score = 55.8 bits (133), Expect = 1e-07
Identities = 53/209 (25%), Positives = 82/209 (39%), Gaps = 47/209 (22%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
LASA D IWK K D E ++ L H V V ++P+G +LA+ D +
Sbjct: 76 LASASFDATTCIWK--KNQDD---FECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVW 130
Query: 92 LWKVNDNKEPEQIAF-----QD------------------EDEAQLNKE---NWTVVKTL 125
+W+V++ E E ++ QD +D +L +E +W TL
Sbjct: 131 VWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATL 190
Query: 126 RGHLEDVYDICWATDGNLMASASVDNTAIIW----------------DVSKGQKISIFNE 169
GH V+ + + G +AS S D T IW D S ++
Sbjct: 191 EGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGF 250
Query: 170 HKSYVQGVTWDPLGQYVATLSCDRVLRVY 198
H + + W L +AT D +RV+
Sbjct: 251 HSRTIYDIAWCQLTGALATACGDDAIRVF 279
Score = 35.0 bits (79), Expect = 0.18
Identities = 43/167 (25%), Positives = 67/167 (40%), Gaps = 34/167 (20%)
Query: 4 ITCEIAWHNKEPVYSLDFQHGTAGRIHRLASAGVDTNVRIWKV-----EKG-------PD 51
+ C ++ V+SL F RLAS D VRIW+ E+G P
Sbjct: 185 VCCATLEGHESTVWSLAFDPSG----QRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPS 240
Query: 52 GKAIVEFLSNLARHTKAV-NVVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDED 110
K I LS H++ + ++ TG + + GDDA I +++ + N +P+Q F
Sbjct: 241 WKCICT-LSGF--HSRTIYDIAWCQLTGALATACGDDA-IRVFQEDPNSDPQQPTFS--- 293
Query: 111 EAQLNKENWTVVKTLRGHLEDVYDICW-ATDGNLMASASVDNTAIIW 156
+ H +DV + W + L+AS S D W
Sbjct: 294 ---------LTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFW 331
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 79.0 bits (193), Expect = 1e-14
Identities = 58/215 (26%), Positives = 93/215 (43%), Gaps = 49/215 (22%)
Query: 62 LARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTV 121
L HT+AV+ V+FSP GE LAS D +I++W D K
Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYE-------------------- 76
Query: 122 VKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDP 181
KTL GH ++ D+ W++D + + SAS D T +WDV G+ + H +YV ++P
Sbjct: 77 -KTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNP 135
Query: 182 LGQYVATLSCDRVLRVYSIQKKR--------------VAFNVSKMLSGIG---------- 217
+ + S D ++++ ++ + V FN S L G
Sbjct: 136 PSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
Query: 218 -AEGEARSYRMFHDDSMKSFFRRLSFTPDGSLLLT 251
A G+ + D+ SF + F+P+G +LT
Sbjct: 196 AASGQCLKTLVDDDNPPVSF---VKFSPNGKYILT 227
Score = 67.0 bits (162), Expect = 4e-11
Identities = 44/175 (25%), Positives = 75/175 (42%), Gaps = 29/175 (16%)
Query: 31 RLASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVI 90
RL SA D +++W V G + L L H+ V F+P ++ SG D +
Sbjct: 97 RLVSASDDKTLKLWDVRSG-------KCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETV 149
Query: 91 LLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVD 150
+W+V K +KTL H + V + + G+L+ S S D
Sbjct: 150 KIWEVKTGK---------------------CLKTLSAHSDPVSAVHFNCSGSLIVSGSYD 188
Query: 151 NTAIIWDVSKGQKI-SIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQKKR 204
IWD + GQ + ++ ++ V V + P G+Y+ T + D L+++ + R
Sbjct: 189 GLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGR 243
Score = 54.3 bits (129), Expect = 3e-07
Identities = 37/177 (20%), Positives = 79/177 (44%), Gaps = 30/177 (16%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
+ S D V+IW+V+ G + L L+ H+ V+ V F+ +G ++ SG D +
Sbjct: 140 IISGSFDETVKIWEVKTG-------KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCR 192
Query: 92 LWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDN 151
+W + + + D K ++ +G + +A++DN
Sbjct: 193 IWDAASGQCLKTLVDDDNPPVSFVK--------------------FSPNGKYILTATLDN 232
Query: 152 TAIIWDVSKGQKISIFNEHKS--YVQGVTWDPL-GQYVATLSCDRVLRVYSIQKKRV 205
T +WD S+G+ + + HK+ Y + G+++ + S D ++ ++++Q K +
Sbjct: 233 TLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI 289
Score = 43.9 bits (102), Expect = 4e-04
Identities = 22/84 (26%), Positives = 40/84 (47%)
Query: 118 NWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGV 177
N+ + TL GH E V + ++ +G +AS+S D IIW G+ H + V
Sbjct: 30 NYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDV 89
Query: 178 TWDPLGQYVATLSCDRVLRVYSIQ 201
W + + S D+ L+++ ++
Sbjct: 90 AWSSDSSRLVSASDDKTLKLWDVR 113
Score = 32.0 bits (71), Expect = 1.5
Identities = 26/125 (20%), Positives = 54/125 (43%), Gaps = 27/125 (21%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTG-EILASGGDDAVI 90
+ +A +D +++W +G + + + + ++ K FS TG + + SG +D ++
Sbjct: 225 ILTATLDNTLKLWDYSRG---RCLKTYTGH--KNEKYCIFANFSVTGGKWIVSGSEDNLV 279
Query: 91 LLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVD 150
+W N + +V+ L+GH + V NL+ASA+++
Sbjct: 280 YIW---------------------NLQTKEIVQKLQGHTDVVISAACHPTENLIASAALE 318
Query: 151 NTAII 155
N I
Sbjct: 319 NDKTI 323
>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
Length = 193
Score = 75.1 bits (183), Expect = 2e-13
Identities = 55/169 (32%), Positives = 78/169 (46%), Gaps = 29/169 (17%)
Query: 31 RLASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVI 90
RL S D + +W + D K L+ + H +N V FSP I+AS D I
Sbjct: 51 RLVSGSDDFTLFLWSPAE--DKKP----LTRMTGHQALINQVLFSPDSRIVASASFDKSI 104
Query: 91 LLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVD 150
LW D + + +A +LRGH+ VY I W+ D L+ S S D
Sbjct: 105 KLW---DGRTGKYLA------------------SLRGHVAAVYQIAWSADSRLLVSGSSD 143
Query: 151 NTAIIWDVSKGQKISI-FNEHKSYVQGVTWDPLGQYVATLSCDRVLRVY 198
+T +WDV K QK+++ H V V W P GQ VA+ D+ LR++
Sbjct: 144 STLKVWDV-KAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 191
Score = 53.1 bits (126), Expect = 6e-07
Identities = 29/131 (22%), Positives = 60/131 (45%), Gaps = 20/131 (15%)
Query: 79 EILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWA 138
E L SG DD + LW ++K+P + + GH + + ++
Sbjct: 50 ERLVSGSDDFTLFLWSPAEDKKP--------------------LTRMTGHQALINQVLFS 89
Query: 139 TDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVY 198
D ++ASAS D + +WD G+ ++ H + V + W + + + S D L+V+
Sbjct: 90 PDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVW 149
Query: 199 SIQKKRVAFNV 209
++ +++A ++
Sbjct: 150 DVKAQKLAMDL 160
Score = 35.0 bits (79), Expect = 0.18
Identities = 18/63 (28%), Positives = 31/63 (49%), Gaps = 7/63 (11%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
L S D+ +++W V+ + +L H V V +SP G+ +ASGG D +
Sbjct: 137 LVSGSSDSTLKVWDVKAQ-------KLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLR 189
Query: 92 LWK 94
+W+
Sbjct: 190 IWR 192
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 75.1 bits (183), Expect = 2e-13
Identities = 55/169 (32%), Positives = 78/169 (46%), Gaps = 29/169 (17%)
Query: 31 RLASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVI 90
RL S D + +W + D K L+ + H +N V FSP I+AS D I
Sbjct: 343 RLVSGSDDFTLFLWSPAE--DKKP----LTRMTGHQALINQVLFSPDSRIVASASFDKSI 396
Query: 91 LLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVD 150
LW D + + +A +LRGH+ VY I W+ D L+ S S D
Sbjct: 397 KLW---DGRTGKYLA------------------SLRGHVAAVYQIAWSADSRLLVSGSSD 435
Query: 151 NTAIIWDVSKGQKISI-FNEHKSYVQGVTWDPLGQYVATLSCDRVLRVY 198
+T +WDV K QK+++ H V V W P GQ VA+ D+ LR++
Sbjct: 436 STLKVWDV-KAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 71.6 bits (174), Expect = 2e-12
Identities = 44/152 (28%), Positives = 72/152 (47%), Gaps = 27/152 (17%)
Query: 53 KAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEA 112
+A+ S+L H++AV V FSPTG+ LASG D + W ++
Sbjct: 101 RAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTE-------------- 146
Query: 113 QLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKIS-IFNEHK 171
T T +GH V I W+ DG +AS + ++WD S G+++ H
Sbjct: 147 -------TPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHS 199
Query: 172 SYVQGVTWDPLG-----QYVATLSCDRVLRVY 198
++ G++W+PL +YVA+ S D +R++
Sbjct: 200 KWITGLSWEPLHANPECRYVASSSKDGSVRIW 231
Score = 53.1 bits (126), Expect = 6e-07
Identities = 29/131 (22%), Positives = 60/131 (45%), Gaps = 20/131 (15%)
Query: 79 EILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWA 138
E L SG DD + LW ++K+P + + GH + + ++
Sbjct: 342 ERLVSGSDDFTLFLWSPAEDKKP--------------------LTRMTGHQALINQVLFS 381
Query: 139 TDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVY 198
D ++ASAS D + +WD G+ ++ H + V + W + + + S D L+V+
Sbjct: 382 PDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVW 441
Query: 199 SIQKKRVAFNV 209
++ +++A ++
Sbjct: 442 DVKAQKLAMDL 452
Score = 35.0 bits (79), Expect = 0.18
Identities = 18/63 (28%), Positives = 31/63 (49%), Gaps = 7/63 (11%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
L S D+ +++W V+ + +L H V V +SP G+ +ASGG D +
Sbjct: 429 LVSGSSDSTLKVWDVKAQ-------KLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLR 481
Query: 92 LWK 94
+W+
Sbjct: 482 IWR 484
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 73.9 bits (180), Expect = 4e-13
Identities = 44/146 (30%), Positives = 71/146 (48%), Gaps = 30/146 (20%)
Query: 65 HTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKT 124
HT VN +++ PTG +LAS DD + +W + + V
Sbjct: 348 HTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDN---------------------CVHD 386
Query: 125 LRGHLEDVYDICWATDG--------NLM-ASASVDNTAIIWDVSKGQKISIFNEHKSYVQ 175
L+ H +++Y I W+ G NLM ASAS D+T +WDV +G I +H+ V
Sbjct: 387 LQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVY 446
Query: 176 GVTWDPLGQYVATLSCDRVLRVYSIQ 201
V + P G+Y+A+ S D+ + +++ Q
Sbjct: 447 SVAFSPDGRYLASGSFDKCVHIWNTQ 472
Score = 60.5 bits (145), Expect = 4e-09
Identities = 43/200 (21%), Positives = 76/200 (38%), Gaps = 37/200 (18%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
LA+ D RIW DG S L +H + ++++ G + S G D +
Sbjct: 240 LATGSYDGFARIWT----KDGN----LASTLGQHKGPIFALKWNKKGNFILSAGVDKTTI 291
Query: 92 LWKVNDNKEPEQIAFQDEDEAQLNKENWTV--------------------VKTLRGHLED 131
+W + + +Q F ++ ++ +KT +GH +
Sbjct: 292 IWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNE 351
Query: 132 VYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQ------- 184
V I W GNL+AS S D T IW + + + H + + W P G
Sbjct: 352 VNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNA 411
Query: 185 --YVATLSCDRVLRVYSIQK 202
+A+ S D +R++ + +
Sbjct: 412 NLMLASASFDSTVRLWDVDR 431
Score = 58.5 bits (140), Expect = 2e-08
Identities = 52/228 (22%), Positives = 82/228 (35%), Gaps = 80/228 (35%)
Query: 50 PDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDN----------- 98
P KA+V L H V + ++P ++LASG D+ +W +++N
Sbjct: 158 PPNKAVV-----LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLR 212
Query: 99 ---KEPEQIAFQDEDEAQL--NKEN--------------WT----VVKTLRGHLEDVYDI 135
+E Q ++D L N E WT + TL H ++ +
Sbjct: 213 HCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFAL 272
Query: 136 CWATDGNLMASASVDNTAIIWDVSKGQ--------------------------------- 162
W GN + SA VD T IIWD G+
Sbjct: 273 KWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIH 332
Query: 163 --------KISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQK 202
I F H + V + WDP G +A+ S D L+++S+++
Sbjct: 333 VCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQ 380
>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
Length = 404
Score = 70.5 bits (171), Expect = 4e-12
Identities = 50/207 (24%), Positives = 94/207 (45%), Gaps = 42/207 (20%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGE-ILASGGDDAVI 90
LA+ D ++IW+V+ G L NL+ H V + F+P+G IL S D +
Sbjct: 126 LATGLNDGQIKIWEVQTGL-------LLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTL 178
Query: 91 LLWKVNDNKEPEQI----------------------AFQDEDEAQLNKENWTVVKTLRGH 128
+W +N + + Q+ A ++ + ++T+++ L GH
Sbjct: 179 RIWDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGH 238
Query: 129 LEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNE------------HKSYVQG 176
V ++ D L+ +AS D I+WD G+++ + H S ++
Sbjct: 239 QSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRS 298
Query: 177 VTWDPLGQYVATLSCDRVLRVYSIQKK 203
V + P G Y+AT++ DR+LR+++++ K
Sbjct: 299 VCFSPEGLYLATVADDRLLRIWALELK 325
Score = 31.6 bits (70), Expect = 2.0
Identities = 28/132 (21%), Positives = 56/132 (42%), Gaps = 23/132 (17%)
Query: 143 LMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYV-ATLSCDRVLRVYSIQ 201
++A+ D IW+V G + + H+ V+ +++ P G + + S D+ LR++ +
Sbjct: 125 VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLN 184
Query: 202 KK-----------------RVAFNVSKMLSGIGAEG----EARSYRMFHD-DSMKSFFRR 239
K ++ + S + S G + RSY + + +S
Sbjct: 185 KHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVS 244
Query: 240 LSFTPDGSLLLT 251
F+PD +LL+T
Sbjct: 245 CDFSPDSALLVT 256
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 69.7 bits (169), Expect = 7e-12
Identities = 42/176 (23%), Positives = 78/176 (44%), Gaps = 28/176 (15%)
Query: 34 SAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLW 93
+A D V++W + +FL +L++H V +FSP G ++ S DD + LW
Sbjct: 82 TASDDKTVKVWATHRQ-------KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 134
Query: 94 KVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTA 153
+K + V + H V + + G +A+A +DNT
Sbjct: 135 ---------------------DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTV 173
Query: 154 IIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQKKRVAFNV 209
+WDV + + + H + V G+++ P G Y+ T S D L++ + + R+ + +
Sbjct: 174 KVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL 229
Score = 56.2 bits (134), Expect = 8e-08
Identities = 52/236 (22%), Positives = 94/236 (39%), Gaps = 49/236 (20%)
Query: 37 VDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKVN 96
+D+ + +W ++ P +A H AV V FSP+G +LASG D + +W N
Sbjct: 1 MDSCLMVWHMK--PQSRAY-----RFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPN 53
Query: 97 DNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIW 156
E R H V + + +DG +AS D T +W
Sbjct: 54 VKGEST---------------------VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 92
Query: 157 DVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQKKRVAFN-------- 208
+ + + ++H ++V+ + P G+ + + S D+ ++++ + +
Sbjct: 93 ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFV 152
Query: 209 --VSKMLSG--IGAEG--------EARSYRMF-HDDSMKSFFRRLSFTPDGSLLLT 251
V SG I A G + R++R+ H + LSF P G+ L+T
Sbjct: 153 TYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLIT 208
Score = 37.7 bits (86), Expect = 0.028
Identities = 22/65 (33%), Positives = 31/65 (47%), Gaps = 7/65 (10%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
L +A D+ ++I + +G L L H V FS TGE ASGG D ++
Sbjct: 206 LITASSDSTLKILDLMEG-------RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVM 258
Query: 92 LWKVN 96
+WK N
Sbjct: 259 VWKSN 263
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 69.7 bits (169), Expect = 7e-12
Identities = 42/176 (23%), Positives = 78/176 (44%), Gaps = 28/176 (15%)
Query: 34 SAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLW 93
+A D V++W + +FL +L++H V +FSP G ++ S DD + LW
Sbjct: 120 TASDDKTVKVWATHRQ-------KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
Query: 94 KVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTA 153
+K + V + H V + + G +A+A +DNT
Sbjct: 173 ---------------------DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTV 211
Query: 154 IIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQKKRVAFNV 209
+WDV + + + H + V G+++ P G Y+ T S D L++ + + R+ + +
Sbjct: 212 KVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL 267
Score = 62.8 bits (151), Expect = 8e-10
Identities = 59/261 (22%), Positives = 106/261 (40%), Gaps = 53/261 (20%)
Query: 12 NKEPVYSLDFQHGTAGRIHRLASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNV 71
+++ V +DF T +LAS +D+ + +W ++ P +A H AV
Sbjct: 18 HRDAVTCVDFSINTK----QLASGSMDSCLMVWHMK--PQSRAY-----RFTGHKDAVTC 66
Query: 72 VRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLED 131
V FSP+G +LASG D + +W N E R H
Sbjct: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGEST---------------------VFRAHTAT 105
Query: 132 VYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSC 191
V + + +DG +AS D T +W + + + ++H ++V+ + P G+ + + S
Sbjct: 106 VRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASD 165
Query: 192 DRVLRVYSIQKKRVAFN----------VSKMLSG--IGAEG--------EARSYRMF-HD 230
D+ ++++ + + V SG I A G + R++R+ H
Sbjct: 166 DKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY 225
Query: 231 DSMKSFFRRLSFTPDGSLLLT 251
+ LSF P G+ L+T
Sbjct: 226 QLHSAAVNGLSFHPSGNYLIT 246
Score = 40.4 bits (93), Expect = 0.004
Identities = 20/82 (24%), Positives = 44/82 (53%)
Query: 117 ENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQG 176
E+ ++ + +GH + V + ++ + +AS S+D+ ++W + + F HK V
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 177 VTWDPLGQYVATLSCDRVLRVY 198
V + P G +A+ S D+ +R++
Sbjct: 67 VNFSPSGHLLASGSRDKTVRIW 88
Score = 37.7 bits (86), Expect = 0.028
Identities = 22/65 (33%), Positives = 31/65 (47%), Gaps = 7/65 (10%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
L +A D+ ++I + +G L L H V FS TGE ASGG D ++
Sbjct: 244 LITASSDSTLKILDLMEG-------RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVM 296
Query: 92 LWKVN 96
+WK N
Sbjct: 297 VWKSN 301
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 69.7 bits (169), Expect = 7e-12
Identities = 42/176 (23%), Positives = 78/176 (44%), Gaps = 28/176 (15%)
Query: 34 SAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLW 93
+A D V++W + +FL +L++H V +FSP G ++ S DD + LW
Sbjct: 120 TASDDKTVKVWATHRQ-------KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
Query: 94 KVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTA 153
+K + V + H V + + G +A+A +DNT
Sbjct: 173 ---------------------DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTV 211
Query: 154 IIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQKKRVAFNV 209
+WDV + + + H + V G+++ P G Y+ T S D L++ + + R+ + +
Sbjct: 212 KVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL 267
Score = 62.8 bits (151), Expect = 8e-10
Identities = 59/261 (22%), Positives = 106/261 (40%), Gaps = 53/261 (20%)
Query: 12 NKEPVYSLDFQHGTAGRIHRLASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNV 71
+++ V +DF T +LAS +D+ + +W ++ P +A H AV
Sbjct: 18 HRDAVTCVDFSINTK----QLASGSMDSCLMVWHMK--PQSRAY-----RFTGHKDAVTC 66
Query: 72 VRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLED 131
V FSP+G +LASG D + +W N E R H
Sbjct: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGEST---------------------VFRAHTAT 105
Query: 132 VYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSC 191
V + + +DG +AS D T +W + + + ++H ++V+ + P G+ + + S
Sbjct: 106 VRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASD 165
Query: 192 DRVLRVYSIQKKRVAFN----------VSKMLSG--IGAEG--------EARSYRMF-HD 230
D+ ++++ + + V SG I A G + R++R+ H
Sbjct: 166 DKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY 225
Query: 231 DSMKSFFRRLSFTPDGSLLLT 251
+ LSF P G+ L+T
Sbjct: 226 QLHSAAVNGLSFHPSGNYLIT 246
Score = 40.4 bits (93), Expect = 0.004
Identities = 20/82 (24%), Positives = 44/82 (53%)
Query: 117 ENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQG 176
E+ ++ + +GH + V + ++ + +AS S+D+ ++W + + F HK V
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 177 VTWDPLGQYVATLSCDRVLRVY 198
V + P G +A+ S D+ +R++
Sbjct: 67 VNFSPSGHLLASGSRDKTVRIW 88
Score = 37.7 bits (86), Expect = 0.028
Identities = 22/65 (33%), Positives = 31/65 (47%), Gaps = 7/65 (10%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
L +A D+ ++I + +G L L H V FS TGE ASGG D ++
Sbjct: 244 LITASSDSTLKILDLMEG-------RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVM 296
Query: 92 LWKVN 96
+WK N
Sbjct: 297 VWKSN 301
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 69.3 bits (168), Expect = 9e-12
Identities = 44/172 (25%), Positives = 77/172 (44%), Gaps = 28/172 (16%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
+ SA D +++W E G +F L HT +V + F +G++LAS D I
Sbjct: 123 MVSASEDATIKVWDYETG-------DFERTLKGHTDSVQDISFDHSGKLLASCSADMTIK 175
Query: 92 LWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDN 151
LW + + ++T+ GH +V + +G+ + SAS D
Sbjct: 176 LWDF---------------------QGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDK 214
Query: 152 TAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQKK 203
T +W+V G + F H+ +V+ V + G +A+ S D+ +RV+ + K
Sbjct: 215 TIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATK 266
Score = 60.5 bits (145), Expect = 4e-09
Identities = 37/140 (26%), Positives = 60/140 (42%), Gaps = 21/140 (15%)
Query: 62 LARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTV 121
L+ H V V F P ++ S +DA I +W + E
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVW---------------------DYETGDF 142
Query: 122 VKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDP 181
+TL+GH + V DI + G L+AS S D T +WD + I + H V V P
Sbjct: 143 ERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMP 202
Query: 182 LGQYVATLSCDRVLRVYSIQ 201
G ++ + S D+ ++++ +Q
Sbjct: 203 NGDHIVSASRDKTIKMWEVQ 222
Score = 57.4 bits (137), Expect = 3e-08
Identities = 48/183 (26%), Positives = 84/183 (45%), Gaps = 28/183 (15%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
+ SA D +++W+V+ G + H + V +VR + G ++AS +D +
Sbjct: 207 IVSASRDKTIKMWEVQTG-------YCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVR 259
Query: 92 LWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYD-ICWATD---------G 141
+W V E +A+L +E+ VV+ + E Y I AT G
Sbjct: 260 VWVVATK----------ECKAEL-REHEHVVECISWAPESSYSSISEATGSETKKSGKPG 308
Query: 142 NLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQ 201
+ S S D T +WDVS G + H ++V+GV + G+++ + + D+ LRV+ +
Sbjct: 309 PFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYK 368
Query: 202 KKR 204
KR
Sbjct: 369 NKR 371
Score = 46.6 bits (109), Expect = 6e-05
Identities = 41/187 (21%), Positives = 66/187 (35%), Gaps = 48/187 (25%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPT-------------- 77
+AS D VR+W V A E + L H V + ++P
Sbjct: 249 IASCSNDQTVRVWVV-------ATKECKAELREHEHVVECISWAPESSYSSISEATGSET 301
Query: 78 ------GEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLED 131
G L SG D I +W V+ + TL GH
Sbjct: 302 KKSGKPGPFLLSGSRDKTIKMWDVSTGM---------------------CLMTLVGHDNW 340
Query: 132 VYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSC 191
V + + + G + S + D T +WD + + N H+ +V + + YV T S
Sbjct: 341 VRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSV 400
Query: 192 DRVLRVY 198
D+ ++V+
Sbjct: 401 DQTVKVW 407
Score = 32.7 bits (73), Expect = 0.90
Identities = 28/126 (22%), Positives = 44/126 (34%), Gaps = 28/126 (22%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
L S D +++W V G L L H V V F G+ + S DD +
Sbjct: 311 LLSGSRDKTIKMWDVSTGM-------CLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLR 363
Query: 92 LWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDN 151
+W + +N +KTL H V + + + + SVD
Sbjct: 364 VW---------------------DYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQ 402
Query: 152 TAIIWD 157
T +W+
Sbjct: 403 TVKVWE 408
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 69.3 bits (168), Expect = 9e-12
Identities = 52/261 (19%), Positives = 108/261 (41%), Gaps = 52/261 (19%)
Query: 12 NKEPVYSLDFQHGTAGRIHRLASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNV 71
++ VY++ F + +I A+ D ++W VE G + HT +
Sbjct: 133 HRNVVYAIAFNNPYGDKI---ATGSFDKTCKLWSVETG-------KCYHTFRGHTAEIVC 182
Query: 72 VRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLED 131
+ F+P ++A+G D LW + + +E V TLRGH +
Sbjct: 183 LSFNPQSTLVATGSMDTTAKLWDIQNGEE---------------------VYTLRGHSAE 221
Query: 132 VYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSC 191
+ + + T G+ + + S D+T ++WD G+K++I H + + +++ + T S
Sbjct: 222 IISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSM 281
Query: 192 DRVLRVYSIQKKRVAFNVS---------------KMLSGIGAEGEARSYR------MFHD 230
D+ +++ + ++ K+++ A+G AR + +
Sbjct: 282 DKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKL 341
Query: 231 DSMKSFFRRLSFTPDGSLLLT 251
+ + ++SF P G+ LLT
Sbjct: 342 EGHEGEISKISFNPQGNHLLT 362
Score = 65.5 bits (158), Expect = 1e-10
Identities = 42/191 (21%), Positives = 87/191 (45%), Gaps = 28/191 (14%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
+A+ +DT ++W ++ G E + L H+ + + F+ +G+ + +G D ++
Sbjct: 192 VATGSMDTTAKLWDIQNG-------EEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVV 244
Query: 92 LWKVNDNK----------EPEQIAFQ-----------DEDEAQLNKENWTVVKTLRGHLE 130
+W + + E +F D+ + N V TL GH +
Sbjct: 245 VWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDD 304
Query: 131 DVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLS 190
++ D C+ G L+A+AS D TA I+ + + I+ H+ + ++++P G ++ T S
Sbjct: 305 EILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGS 364
Query: 191 CDRVLRVYSIQ 201
D+ R++ Q
Sbjct: 365 SDKTARIWDAQ 375
Score = 48.1 bits (113), Expect = 2e-05
Identities = 29/139 (20%), Positives = 66/139 (47%), Gaps = 3/139 (2%)
Query: 66 TKAVNVVRFSPTGEI--LASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVK 123
TK+++++ P+ ++ L A LL + I E Q + + + K
Sbjct: 27 TKSIDLLDLGPSTDVSALVEEIQKAEPLLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFK 86
Query: 124 TLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTW-DPL 182
L+ H+ + ++ G+ + S D T +WD + G++++ H++ V + + +P
Sbjct: 87 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPY 146
Query: 183 GQYVATLSCDRVLRVYSIQ 201
G +AT S D+ +++S++
Sbjct: 147 GDKIATGSFDKTCKLWSVE 165
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 69.3 bits (168), Expect = 9e-12
Identities = 45/178 (25%), Positives = 80/178 (44%), Gaps = 28/178 (15%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
LAS D +V++W ++ E ++++ HT V V + P+G L + D
Sbjct: 296 LASCAADGSVKLWSLDSD-------EPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWR 348
Query: 92 LWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDN 151
LW D + E+I Q+ GH VYDI + DG+L + +D
Sbjct: 349 LW---DLEAQEEILHQE------------------GHSMGVYDIAFHQDGSLAGTGGLDA 387
Query: 152 TAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQKKRVAFNV 209
+WD+ G+ I H + G+ + P G ++AT S D +V+ ++++R + +
Sbjct: 388 FGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTI 445
Score = 48.5 bits (114), Expect = 2e-05
Identities = 39/166 (23%), Positives = 64/166 (38%), Gaps = 29/166 (17%)
Query: 34 SAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLW 93
+ G+D R+W + G + FL H K + + FSP G +A+G D +W
Sbjct: 382 TGGLDAFGRVWDLRTG----RCIMFLEG---HLKEIYGINFSPNGYHIATGSGDNTCKVW 434
Query: 94 KVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWAT-DGNLMASASVDNT 152
+ + V T+ H V + + GN + + + DNT
Sbjct: 435 DLRQRR---------------------CVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNT 473
Query: 153 AIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVY 198
A IW + H+ V G+ GQ +AT S DR +++
Sbjct: 474 AKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 47.4 bits (111), Expect = 4e-05
Identities = 46/218 (21%), Positives = 86/218 (39%), Gaps = 52/218 (23%)
Query: 67 KAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLR 126
+ ++ FSP ++LA+ + LW V D ++ TLR
Sbjct: 232 RPISYCHFSPNSKMLATACWSGLCKLWSVPD---------------------CNLLHTLR 270
Query: 127 GHLEDVYDICWATDGNL--------MASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVT 178
GH +V I + + +AS + D + +W + + ++ H V V
Sbjct: 271 GHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVM 330
Query: 179 WDPLGQYVATLSCDRVLRVYSIQKKR--------------VAFNVSKMLSGIG---AEGE 221
W P G+++ T DR R++ ++ + +AF+ L+G G A G
Sbjct: 331 WHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGR 390
Query: 222 ARSYR-----MFHDDSMKSFFRRLSFTPDGSLLLTPAG 254
R MF + +K + ++F+P+G + T +G
Sbjct: 391 VWDLRTGRCIMFLEGHLKEIY-GINFSPNGYHIATGSG 427
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 69.3 bits (168), Expect = 9e-12
Identities = 47/196 (23%), Positives = 88/196 (44%), Gaps = 42/196 (21%)
Query: 15 PVYSLDFQHGTAGRIHRLASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRF 74
P +D+Q+ T AS D + + ++ G D + HT VN +++
Sbjct: 322 PALDVDWQNNTT-----FASCSTDMCIHVCRL--GCDRP-----VKTFQGHTNEVNAIKW 369
Query: 75 SPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYD 134
P+G +LAS DD + +W + +++ D L+ H +++Y
Sbjct: 370 DPSGMLLASCSDDMTLKIWSMK-----QEVCIHD----------------LQAHNKEIYT 408
Query: 135 ICWATDGN---------LMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQY 185
I W+ G ++ASAS D+T +WD+ +G +H+ V V + P G+Y
Sbjct: 409 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKY 468
Query: 186 VATLSCDRVLRVYSIQ 201
+A+ S D+ + +++ Q
Sbjct: 469 LASGSFDKCVHIWNTQ 484
Score = 58.5 bits (140), Expect = 2e-08
Identities = 47/220 (21%), Positives = 78/220 (35%), Gaps = 70/220 (31%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARH-------TKAVNVVRFSPTGEILASG 84
LAS D+ RIW + + +G + L + R K V + ++ G +LA+G
Sbjct: 196 LASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATG 255
Query: 85 GDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLM 144
D +W + N + TL H ++ + W GN +
Sbjct: 256 SYDGFARIWTEDGN----------------------LASTLGQHKGPIFALKWNRKGNYI 293
Query: 145 ASASVDNTAIIWDVSKGQK----------------------------------------- 163
SA VD T IIWD G+
Sbjct: 294 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRP 353
Query: 164 ISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQKK 203
+ F H + V + WDP G +A+ S D L+++S++++
Sbjct: 354 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE 393
Score = 40.8 bits (94), Expect = 0.003
Identities = 33/119 (27%), Positives = 54/119 (45%), Gaps = 21/119 (17%)
Query: 95 VNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAI 154
VN++ +P +I + E ++ TV LRGH +V+ W +L+AS S D+TA
Sbjct: 154 VNNHAKPMEI----DGEVEIPSSKATV---LRGHESEVFICAWNPVSDLLASGSGDSTAR 206
Query: 155 IWDV---SKGQKISIFNEH-----------KSYVQGVTWDPLGQYVATLSCDRVLRVYS 199
IW++ S G + H V + W+ G +AT S D R+++
Sbjct: 207 IWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWT 265
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 69.3 bits (168), Expect = 9e-12
Identities = 47/196 (23%), Positives = 88/196 (44%), Gaps = 42/196 (21%)
Query: 15 PVYSLDFQHGTAGRIHRLASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRF 74
P +D+Q+ T AS D + + ++ G D + HT VN +++
Sbjct: 322 PALDVDWQNNTT-----FASCSTDMCIHVCRL--GCDRP-----VKTFQGHTNEVNAIKW 369
Query: 75 SPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYD 134
P+G +LAS DD + +W + +++ D L+ H +++Y
Sbjct: 370 DPSGMLLASCSDDMTLKIWSMK-----QEVCIHD----------------LQAHNKEIYT 408
Query: 135 ICWATDGN---------LMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQY 185
I W+ G ++ASAS D+T +WD+ +G +H+ V V + P G+Y
Sbjct: 409 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKY 468
Query: 186 VATLSCDRVLRVYSIQ 201
+A+ S D+ + +++ Q
Sbjct: 469 LASGSFDKCVHIWNTQ 484
Score = 58.5 bits (140), Expect = 2e-08
Identities = 47/220 (21%), Positives = 78/220 (35%), Gaps = 70/220 (31%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARH-------TKAVNVVRFSPTGEILASG 84
LAS D+ RIW + + +G + L + R K V + ++ G +LA+G
Sbjct: 196 LASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATG 255
Query: 85 GDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLM 144
D +W + N + TL H ++ + W GN +
Sbjct: 256 SYDGFARIWTEDGN----------------------LASTLGQHKGPIFALKWNRKGNYI 293
Query: 145 ASASVDNTAIIWDVSKGQK----------------------------------------- 163
SA VD T IIWD G+
Sbjct: 294 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRP 353
Query: 164 ISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQKK 203
+ F H + V + WDP G +A+ S D L+++S++++
Sbjct: 354 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE 393
Score = 40.8 bits (94), Expect = 0.003
Identities = 33/119 (27%), Positives = 54/119 (45%), Gaps = 21/119 (17%)
Query: 95 VNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAI 154
VN++ +P +I + E ++ TV LRGH +V+ W +L+AS S D+TA
Sbjct: 154 VNNHAKPMEI----DGEVEIPSSKATV---LRGHESEVFICAWNPVSDLLASGSGDSTAR 206
Query: 155 IWDV---SKGQKISIFNEH-----------KSYVQGVTWDPLGQYVATLSCDRVLRVYS 199
IW++ S G + H V + W+ G +AT S D R+++
Sbjct: 207 IWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWT 265
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 69.3 bits (168), Expect = 9e-12
Identities = 47/196 (23%), Positives = 88/196 (44%), Gaps = 42/196 (21%)
Query: 15 PVYSLDFQHGTAGRIHRLASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRF 74
P +D+Q+ T AS D + + ++ G D + HT VN +++
Sbjct: 373 PALDVDWQNNTT-----FASCSTDMCIHVCRL--GCDRP-----VKTFQGHTNEVNAIKW 420
Query: 75 SPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYD 134
P+G +LAS DD + +W + +++ D L+ H +++Y
Sbjct: 421 DPSGMLLASCSDDMTLKIWSMK-----QEVCIHD----------------LQAHNKEIYT 459
Query: 135 ICWATDGN---------LMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQY 185
I W+ G ++ASAS D+T +WD+ +G +H+ V V + P G+Y
Sbjct: 460 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKY 519
Query: 186 VATLSCDRVLRVYSIQ 201
+A+ S D+ + +++ Q
Sbjct: 520 LASGSFDKCVHIWNTQ 535
Score = 58.5 bits (140), Expect = 2e-08
Identities = 47/220 (21%), Positives = 78/220 (35%), Gaps = 70/220 (31%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARH-------TKAVNVVRFSPTGEILASG 84
LAS D+ RIW + + +G + L + R K V + ++ G +LA+G
Sbjct: 247 LASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATG 306
Query: 85 GDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLM 144
D +W + N + TL H ++ + W GN +
Sbjct: 307 SYDGFARIWTEDGN----------------------LASTLGQHKGPIFALKWNRKGNYI 344
Query: 145 ASASVDNTAIIWDVSKGQK----------------------------------------- 163
SA VD T IIWD G+
Sbjct: 345 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRP 404
Query: 164 ISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQKK 203
+ F H + V + WDP G +A+ S D L+++S++++
Sbjct: 405 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE 444
Score = 40.8 bits (94), Expect = 0.003
Identities = 33/119 (27%), Positives = 54/119 (45%), Gaps = 21/119 (17%)
Query: 95 VNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAI 154
VN++ +P +I + E ++ TV LRGH +V+ W +L+AS S D+TA
Sbjct: 205 VNNHAKPMEI----DGEVEIPSSKATV---LRGHESEVFICAWNPVSDLLASGSGDSTAR 257
Query: 155 IWDV---SKGQKISIFNEH-----------KSYVQGVTWDPLGQYVATLSCDRVLRVYS 199
IW++ S G + H V + W+ G +AT S D R+++
Sbjct: 258 IWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWT 316
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 69.3 bits (168), Expect = 9e-12
Identities = 47/196 (23%), Positives = 88/196 (44%), Gaps = 42/196 (21%)
Query: 15 PVYSLDFQHGTAGRIHRLASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRF 74
P +D+Q+ T AS D + + ++ G D + HT VN +++
Sbjct: 373 PALDVDWQNNTT-----FASCSTDMCIHVCRL--GCDRP-----VKTFQGHTNEVNAIKW 420
Query: 75 SPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYD 134
P+G +LAS DD + +W + +++ D L+ H +++Y
Sbjct: 421 DPSGMLLASCSDDMTLKIWSMK-----QEVCIHD----------------LQAHNKEIYT 459
Query: 135 ICWATDGN---------LMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQY 185
I W+ G ++ASAS D+T +WD+ +G +H+ V V + P G+Y
Sbjct: 460 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKY 519
Query: 186 VATLSCDRVLRVYSIQ 201
+A+ S D+ + +++ Q
Sbjct: 520 LASGSFDKCVHIWNTQ 535
Score = 58.5 bits (140), Expect = 2e-08
Identities = 47/220 (21%), Positives = 78/220 (35%), Gaps = 70/220 (31%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARH-------TKAVNVVRFSPTGEILASG 84
LAS D+ RIW + + +G + L + R K V + ++ G +LA+G
Sbjct: 247 LASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATG 306
Query: 85 GDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLM 144
D +W + N + TL H ++ + W GN +
Sbjct: 307 SYDGFARIWTEDGN----------------------LASTLGQHKGPIFALKWNRKGNYI 344
Query: 145 ASASVDNTAIIWDVSKGQK----------------------------------------- 163
SA VD T IIWD G+
Sbjct: 345 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRP 404
Query: 164 ISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQKK 203
+ F H + V + WDP G +A+ S D L+++S++++
Sbjct: 405 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE 444
Score = 40.8 bits (94), Expect = 0.003
Identities = 33/119 (27%), Positives = 54/119 (45%), Gaps = 21/119 (17%)
Query: 95 VNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAI 154
VN++ +P +I + E ++ TV LRGH +V+ W +L+AS S D+TA
Sbjct: 205 VNNHAKPMEI----DGEVEIPSSKATV---LRGHESEVFICAWNPVSDLLASGSGDSTAR 257
Query: 155 IWDV---SKGQKISIFNEH-----------KSYVQGVTWDPLGQYVATLSCDRVLRVYS 199
IW++ S G + H V + W+ G +AT S D R+++
Sbjct: 258 IWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWT 316
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 68.6 bits (166), Expect = 1e-11
Identities = 55/190 (28%), Positives = 80/190 (42%), Gaps = 33/190 (17%)
Query: 7 EIAWHNKEPVYSLDFQHGTAGRIHRLASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHT 66
+I + + PVY F + L S+ D VR+W ++ L H
Sbjct: 537 KILYGHSGPVYGASFSPDR----NYLLSSSEDGTVRLWSLQT-------FTCLVGYKGHN 585
Query: 67 KAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLR 126
V +FSP G SGG D V LW D+ +P +I
Sbjct: 586 YPVWDTQFSPYGYYFVSGGHDRVARLW-ATDHYQPLRI--------------------FA 624
Query: 127 GHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYV 186
GHL DV + + N +A+ S D T +WDV G + IF HK + +T+ P G+++
Sbjct: 625 GHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFL 684
Query: 187 ATLSCD-RVL 195
AT + D RVL
Sbjct: 685 ATGATDGRVL 694
Score = 57.0 bits (136), Expect = 4e-08
Identities = 45/205 (21%), Positives = 80/205 (39%), Gaps = 37/205 (18%)
Query: 1 MKVITCEIAW--HNKEPVYSLDFQ-HGTAGRIHRLASAGVDTNVRIWKVEKGPDGKAIVE 57
++ TC + + HN PV+ F +G + S G D R+W + +
Sbjct: 572 LQTFTCLVGYKGHNY-PVWDTQFSPYG-----YYFVSGGHDRVARLWATDH-------YQ 618
Query: 58 FLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKE 117
L A H VN RF P +A+G D + LW V
Sbjct: 619 PLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVL--------------------- 657
Query: 118 NWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGV 177
N V+ GH ++ + ++ +G +A+ + D ++WD+ G + H V +
Sbjct: 658 NGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSL 717
Query: 178 TWDPLGQYVATLSCDRVLRVYSIQK 202
+ G+ +A+ S D +R++ K
Sbjct: 718 RFSRDGEILASGSMDNTVRLWDAIK 742
Score = 50.1 bits (118), Expect = 5e-06
Identities = 40/155 (25%), Positives = 61/155 (39%), Gaps = 22/155 (14%)
Query: 46 VEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIA 105
+E+ D K E L L H+ V FSP L S +D + LW +
Sbjct: 524 LERIMDEKTASE-LKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL---------- 572
Query: 106 FQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKIS 165
+ +T + +GH V+D ++ G S D A +W Q +
Sbjct: 573 -----------QTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLR 621
Query: 166 IFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSI 200
IF H + V + P YVAT S DR +R++ +
Sbjct: 622 IFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDV 656
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 68.6 bits (166), Expect = 1e-11
Identities = 39/146 (26%), Positives = 69/146 (47%), Gaps = 30/146 (20%)
Query: 65 HTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKT 124
HT VN +++ P+G +LAS DD + +W + + V
Sbjct: 358 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQD---------------------ACVHD 396
Query: 125 LRGHLEDVYDICWATDGN---------LMASASVDNTAIIWDVSKGQKISIFNEHKSYVQ 175
L+ H +++Y I W+ G ++ASAS D+T +WDV +G +H+ V
Sbjct: 397 LQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVY 456
Query: 176 GVTWDPLGQYVATLSCDRVLRVYSIQ 201
V + P G+Y+A+ S D+ + +++ Q
Sbjct: 457 SVAFSPDGKYLASGSFDKYVHIWNTQ 482
Score = 59.7 bits (143), Expect = 7e-09
Identities = 56/263 (21%), Positives = 96/263 (36%), Gaps = 60/263 (22%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
LA D RIW E G S L +H + ++++ G + S G D +
Sbjct: 250 LAMGSYDGFARIW-TENG-------NLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTI 301
Query: 92 LWKVNDNKEPEQIAFQDEDEAQLNKENWTV--------------------VKTLRGHLED 131
+W + + +Q F ++ +N VKT +GH +
Sbjct: 302 IWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNE 361
Query: 132 VYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQ------- 184
V I W G L+AS S D T IW + + + H + + W P G
Sbjct: 362 VNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNS 421
Query: 185 --YVATLSCDRVLRVYSIQKKRVAFNVSKMLSGIGAEGEARSYRMFHDDSMKSFFRRLSF 242
+A+ S D +R++ ++ +G M H + + S ++F
Sbjct: 422 SIMLASASFDSTVRLWDVE-----------------QGVCTHTLMKHQEPVYS----VAF 460
Query: 243 TPDGSLLLTPAGCVESGENVMNT 265
+PDG L +G + ++ NT
Sbjct: 461 SPDGKYL--ASGSFDKYVHIWNT 481
Score = 59.3 bits (142), Expect = 9e-09
Identities = 79/343 (23%), Positives = 132/343 (38%), Gaps = 58/343 (16%)
Query: 50 PDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKE--PEQIAFQ 107
P KA V L H V + ++P ++LASG D+ +W +N+N Q+ +
Sbjct: 168 PPNKATV-----LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLR 222
Query: 108 DEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIF 167
+E V + + DV + W +DG L+A S D A IW G S
Sbjct: 223 -----HCIREGGHDVPSNK----DVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTL 272
Query: 168 NEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQ----KKRVAFNVSKML---------- 213
+HK + + W+ G YV + D+ ++ K++ F+ + L
Sbjct: 273 GQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTF 332
Query: 214 SGIGAEGEARSYRMFHDDSMKSF------FRRLSFTPDGSLLLTPAGCVESGENVMNTTY 267
+ + R+ D +K+F + + P G LL A C + T
Sbjct: 333 ASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLL---ASCSDD-----MTLK 384
Query: 268 VFSRKNLKRPIAHLPCPGKATLAVRCCPVYFELRPVVETGVELMSLPYRLVFAVASEDS- 326
++S K + L K ++ P TG + ++ A AS DS
Sbjct: 385 IWSMKQ-DACVHDLQAHSKEIYTIKWSP----------TGPATSNPNSSIMLASASFDST 433
Query: 327 VLLYDTQQSFPFGYVSNIHYHTLSDISWSSDGAFLAISSTDGY 369
V L+D +Q + H + +++S DG +LA S D Y
Sbjct: 434 VRLWDVEQGV-CTHTLMKHQEPVYSVAFSPDGKYLASGSFDKY 475
Score = 58.9 bits (141), Expect = 1e-08
Identities = 48/219 (21%), Positives = 76/219 (34%), Gaps = 70/219 (31%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARH-------TKAVNVVRFSPTGEILASG 84
LAS D+ RIW + + +G + L + R K V + ++ G +LA G
Sbjct: 194 LASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMG 253
Query: 85 GDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLM 144
D +W N N + TL H ++ + W GN +
Sbjct: 254 SYDGFARIWTENGN----------------------LASTLGQHKGPIFALKWNKKGNYV 291
Query: 145 ASASVDNTAIIWDVSKGQ-----------------------------------------K 163
SA VD T IIWD G+
Sbjct: 292 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHP 351
Query: 164 ISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQK 202
+ F H + V + WDP G +A+ S D L+++S+++
Sbjct: 352 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ 390
Score = 53.5 bits (127), Expect = 5e-07
Identities = 41/170 (24%), Positives = 67/170 (39%), Gaps = 38/170 (22%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGE---------ILA 82
LAS D ++IW +++ + +L H+K + +++SPTG +LA
Sbjct: 374 LASCSDDMTLKIWSMKQDA-------CVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLA 426
Query: 83 SGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGN 142
S D+ + LW V E TL H E VY + ++ DG
Sbjct: 427 SASFDSTVRLWDV---------------------EQGVCTHTLMKHQEPVYSVAFSPDGK 465
Query: 143 LMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCD 192
+AS S D IW+ G + + + + V W+ G V + D
Sbjct: 466 YLASGSFDKYVHIWNTQSGSLVHSY-QGTGGIFEVCWNARGDKVGASASD 514
Score = 37.0 bits (84), Expect = 0.048
Identities = 30/120 (25%), Positives = 54/120 (45%), Gaps = 21/120 (17%)
Query: 94 KVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTA 153
++N++ +P +I + + ++ TV LRGH +V+ W +L+AS S D+TA
Sbjct: 151 EINNHSKPMEI----DGDVEIPPNKATV---LRGHESEVFICAWNPVSDLLASGSGDSTA 203
Query: 154 IIWDV---SKGQKISIFNEH-----------KSYVQGVTWDPLGQYVATLSCDRVLRVYS 199
IW++ S G + H V + W+ G +A S D R+++
Sbjct: 204 RIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWT 263
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 68.6 bits (166), Expect = 1e-11
Identities = 39/146 (26%), Positives = 69/146 (47%), Gaps = 30/146 (20%)
Query: 65 HTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKT 124
HT VN +++ P+G +LAS DD + +W + + V
Sbjct: 358 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQD---------------------ACVHD 396
Query: 125 LRGHLEDVYDICWATDGN---------LMASASVDNTAIIWDVSKGQKISIFNEHKSYVQ 175
L+ H +++Y I W+ G ++ASAS D+T +WDV +G +H+ V
Sbjct: 397 LQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVY 456
Query: 176 GVTWDPLGQYVATLSCDRVLRVYSIQ 201
V + P G+Y+A+ S D+ + +++ Q
Sbjct: 457 SVAFSPDGKYLASGSFDKYVHIWNTQ 482
Score = 59.7 bits (143), Expect = 7e-09
Identities = 56/263 (21%), Positives = 96/263 (36%), Gaps = 60/263 (22%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
LA D RIW E G S L +H + ++++ G + S G D +
Sbjct: 250 LAMGSYDGFARIW-TENG-------NLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTI 301
Query: 92 LWKVNDNKEPEQIAFQDEDEAQLNKENWTV--------------------VKTLRGHLED 131
+W + + +Q F ++ +N VKT +GH +
Sbjct: 302 IWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNE 361
Query: 132 VYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQ------- 184
V I W G L+AS S D T IW + + + H + + W P G
Sbjct: 362 VNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNS 421
Query: 185 --YVATLSCDRVLRVYSIQKKRVAFNVSKMLSGIGAEGEARSYRMFHDDSMKSFFRRLSF 242
+A+ S D +R++ ++ +G M H + + S ++F
Sbjct: 422 SIMLASASFDSTVRLWDVE-----------------QGVCTHTLMKHQEPVYS----VAF 460
Query: 243 TPDGSLLLTPAGCVESGENVMNT 265
+PDG L +G + ++ NT
Sbjct: 461 SPDGKYL--ASGSFDKYVHIWNT 481
Score = 59.3 bits (142), Expect = 9e-09
Identities = 79/343 (23%), Positives = 132/343 (38%), Gaps = 58/343 (16%)
Query: 50 PDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKE--PEQIAFQ 107
P KA V L H V + ++P ++LASG D+ +W +N+N Q+ +
Sbjct: 168 PPNKATV-----LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLR 222
Query: 108 DEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIF 167
+E V + + DV + W +DG L+A S D A IW G S
Sbjct: 223 -----HCIREGGHDVPSNK----DVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTL 272
Query: 168 NEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQ----KKRVAFNVSKML---------- 213
+HK + + W+ G YV + D+ ++ K++ F+ + L
Sbjct: 273 GQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTF 332
Query: 214 SGIGAEGEARSYRMFHDDSMKSF------FRRLSFTPDGSLLLTPAGCVESGENVMNTTY 267
+ + R+ D +K+F + + P G LL A C + T
Sbjct: 333 ASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLL---ASCSDD-----MTLK 384
Query: 268 VFSRKNLKRPIAHLPCPGKATLAVRCCPVYFELRPVVETGVELMSLPYRLVFAVASEDS- 326
++S K + L K ++ P TG + ++ A AS DS
Sbjct: 385 IWSMKQ-DACVHDLQAHSKEIYTIKWSP----------TGPATSNPNSSIMLASASFDST 433
Query: 327 VLLYDTQQSFPFGYVSNIHYHTLSDISWSSDGAFLAISSTDGY 369
V L+D +Q + H + +++S DG +LA S D Y
Sbjct: 434 VRLWDVEQGV-CTHTLMKHQEPVYSVAFSPDGKYLASGSFDKY 475
Score = 58.9 bits (141), Expect = 1e-08
Identities = 48/219 (21%), Positives = 76/219 (34%), Gaps = 70/219 (31%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARH-------TKAVNVVRFSPTGEILASG 84
LAS D+ RIW + + +G + L + R K V + ++ G +LA G
Sbjct: 194 LASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMG 253
Query: 85 GDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLM 144
D +W N N + TL H ++ + W GN +
Sbjct: 254 SYDGFARIWTENGN----------------------LASTLGQHKGPIFALKWNKKGNYV 291
Query: 145 ASASVDNTAIIWDVSKGQ-----------------------------------------K 163
SA VD T IIWD G+
Sbjct: 292 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHP 351
Query: 164 ISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQK 202
+ F H + V + WDP G +A+ S D L+++S+++
Sbjct: 352 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ 390
Score = 53.5 bits (127), Expect = 5e-07
Identities = 41/170 (24%), Positives = 67/170 (39%), Gaps = 38/170 (22%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGE---------ILA 82
LAS D ++IW +++ + +L H+K + +++SPTG +LA
Sbjct: 374 LASCSDDMTLKIWSMKQDA-------CVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLA 426
Query: 83 SGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGN 142
S D+ + LW V E TL H E VY + ++ DG
Sbjct: 427 SASFDSTVRLWDV---------------------EQGVCTHTLMKHQEPVYSVAFSPDGK 465
Query: 143 LMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCD 192
+AS S D IW+ G + + + + V W+ G V + D
Sbjct: 466 YLASGSFDKYVHIWNTQSGSLVHSY-QGTGGIFEVCWNARGDKVGASASD 514
Score = 37.0 bits (84), Expect = 0.048
Identities = 30/120 (25%), Positives = 54/120 (45%), Gaps = 21/120 (17%)
Query: 94 KVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTA 153
++N++ +P +I + + ++ TV LRGH +V+ W +L+AS S D+TA
Sbjct: 151 EINNHSKPMEI----DGDVEIPPNKATV---LRGHESEVFICAWNPVSDLLASGSGDSTA 203
Query: 154 IIWDV---SKGQKISIFNEH-----------KSYVQGVTWDPLGQYVATLSCDRVLRVYS 199
IW++ S G + H V + W+ G +A S D R+++
Sbjct: 204 RIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWT 263
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 68.6 bits (166), Expect = 1e-11
Identities = 39/146 (26%), Positives = 69/146 (47%), Gaps = 30/146 (20%)
Query: 65 HTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKT 124
HT VN +++ P+G +LAS DD + +W + + V
Sbjct: 358 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQD---------------------ACVHD 396
Query: 125 LRGHLEDVYDICWATDGN---------LMASASVDNTAIIWDVSKGQKISIFNEHKSYVQ 175
L+ H +++Y I W+ G ++ASAS D+T +WDV +G +H+ V
Sbjct: 397 LQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVY 456
Query: 176 GVTWDPLGQYVATLSCDRVLRVYSIQ 201
V + P G+Y+A+ S D+ + +++ Q
Sbjct: 457 SVAFSPDGKYLASGSFDKYVHIWNTQ 482
Score = 59.7 bits (143), Expect = 7e-09
Identities = 56/263 (21%), Positives = 96/263 (36%), Gaps = 60/263 (22%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
LA D RIW E G S L +H + ++++ G + S G D +
Sbjct: 250 LAMGSYDGFARIW-TENG-------NLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTI 301
Query: 92 LWKVNDNKEPEQIAFQDEDEAQLNKENWTV--------------------VKTLRGHLED 131
+W + + +Q F ++ +N VKT +GH +
Sbjct: 302 IWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNE 361
Query: 132 VYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQ------- 184
V I W G L+AS S D T IW + + + H + + W P G
Sbjct: 362 VNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNS 421
Query: 185 --YVATLSCDRVLRVYSIQKKRVAFNVSKMLSGIGAEGEARSYRMFHDDSMKSFFRRLSF 242
+A+ S D +R++ ++ +G M H + + S ++F
Sbjct: 422 SIMLASASFDSTVRLWDVE-----------------QGVCTHTLMKHQEPVYS----VAF 460
Query: 243 TPDGSLLLTPAGCVESGENVMNT 265
+PDG L +G + ++ NT
Sbjct: 461 SPDGKYL--ASGSFDKYVHIWNT 481
Score = 59.3 bits (142), Expect = 9e-09
Identities = 79/343 (23%), Positives = 132/343 (38%), Gaps = 58/343 (16%)
Query: 50 PDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKE--PEQIAFQ 107
P KA V L H V + ++P ++LASG D+ +W +N+N Q+ +
Sbjct: 168 PPNKATV-----LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLR 222
Query: 108 DEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIF 167
+E V + + DV + W +DG L+A S D A IW G S
Sbjct: 223 -----HCIREGGHDVPSNK----DVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTL 272
Query: 168 NEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQ----KKRVAFNVSKML---------- 213
+HK + + W+ G YV + D+ ++ K++ F+ + L
Sbjct: 273 GQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTF 332
Query: 214 SGIGAEGEARSYRMFHDDSMKSF------FRRLSFTPDGSLLLTPAGCVESGENVMNTTY 267
+ + R+ D +K+F + + P G LL A C + T
Sbjct: 333 ASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLL---ASCSDD-----MTLK 384
Query: 268 VFSRKNLKRPIAHLPCPGKATLAVRCCPVYFELRPVVETGVELMSLPYRLVFAVASEDS- 326
++S K + L K ++ P TG + ++ A AS DS
Sbjct: 385 IWSMKQ-DACVHDLQAHSKEIYTIKWSP----------TGPATSNPNSSIMLASASFDST 433
Query: 327 VLLYDTQQSFPFGYVSNIHYHTLSDISWSSDGAFLAISSTDGY 369
V L+D +Q + H + +++S DG +LA S D Y
Sbjct: 434 VRLWDVEQGV-CTHTLMKHQEPVYSVAFSPDGKYLASGSFDKY 475
Score = 58.9 bits (141), Expect = 1e-08
Identities = 48/219 (21%), Positives = 76/219 (34%), Gaps = 70/219 (31%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARH-------TKAVNVVRFSPTGEILASG 84
LAS D+ RIW + + +G + L + R K V + ++ G +LA G
Sbjct: 194 LASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMG 253
Query: 85 GDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLM 144
D +W N N + TL H ++ + W GN +
Sbjct: 254 SYDGFARIWTENGN----------------------LASTLGQHKGPIFALKWNKKGNYV 291
Query: 145 ASASVDNTAIIWDVSKGQ-----------------------------------------K 163
SA VD T IIWD G+
Sbjct: 292 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHP 351
Query: 164 ISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQK 202
+ F H + V + WDP G +A+ S D L+++S+++
Sbjct: 352 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ 390
Score = 53.5 bits (127), Expect = 5e-07
Identities = 41/170 (24%), Positives = 67/170 (39%), Gaps = 38/170 (22%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGE---------ILA 82
LAS D ++IW +++ + +L H+K + +++SPTG +LA
Sbjct: 374 LASCSDDMTLKIWSMKQDA-------CVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLA 426
Query: 83 SGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGN 142
S D+ + LW V E TL H E VY + ++ DG
Sbjct: 427 SASFDSTVRLWDV---------------------EQGVCTHTLMKHQEPVYSVAFSPDGK 465
Query: 143 LMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCD 192
+AS S D IW+ G + + + + V W+ G V + D
Sbjct: 466 YLASGSFDKYVHIWNTQSGSLVHSY-QGTGGIFEVCWNARGDKVGASASD 514
Score = 37.0 bits (84), Expect = 0.048
Identities = 30/120 (25%), Positives = 54/120 (45%), Gaps = 21/120 (17%)
Query: 94 KVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTA 153
++N++ +P +I + + ++ TV LRGH +V+ W +L+AS S D+TA
Sbjct: 151 EINNHSKPMEI----DGDVEIPPNKATV---LRGHESEVFICAWNPVSDLLASGSGDSTA 203
Query: 154 IIWDV---SKGQKISIFNEH-----------KSYVQGVTWDPLGQYVATLSCDRVLRVYS 199
IW++ S G + H V + W+ G +A S D R+++
Sbjct: 204 RIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWT 263
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 67.8 bits (164), Expect = 3e-11
Identities = 51/187 (27%), Positives = 86/187 (45%), Gaps = 42/187 (22%)
Query: 65 HTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKT 124
H A+ + SP G+ LA+ D ++LW N +P A++
Sbjct: 17 HKAAITSLDLSPNGKQLATASWDTFLMLW----NFKPHARAYR----------------- 55
Query: 125 LRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQ 184
GH + V + ++ GNL+ASAS D T +W K K S F H + V+ V + GQ
Sbjct: 56 YVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ 115
Query: 185 YVATLSCDRVLRVYSIQKKRVAFNVSKMLSGIGAEGEARSYRMFHDDSMKSFFRRLSFTP 244
++AT S D+ ++V+S+ ++R +++ YR H + R F+P
Sbjct: 116 FLATASEDKSIKVWSMYRQRFLYSL---------------YRHTH------WVRCAKFSP 154
Query: 245 DGSLLLT 251
DG L+++
Sbjct: 155 DGRLIVS 161
Score = 65.5 bits (158), Expect = 1e-10
Identities = 46/195 (23%), Positives = 82/195 (42%), Gaps = 32/195 (16%)
Query: 15 PVYSLDFQHGTAGRIHRLASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRF 74
PV S+DF G+ LA+A D ++++W + + FL +L RHT V +F
Sbjct: 104 PVRSVDFS--ADGQF--LATASEDKSIKVWSMYRQ-------RFLYSLYRHTHWVRCAKF 152
Query: 75 SPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYD 134
SP G ++ S +D I +W + + V +
Sbjct: 153 SPDGRLIVSCSEDKTIKIWDTTNKQ---------------------CVNNFSDSVGFANF 191
Query: 135 ICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRV 194
+ + G +ASA D T +WDV + + + H V +++ P G Y+ T S D
Sbjct: 192 VDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251
Query: 195 LRVYSIQKKRVAFNV 209
L++ + + R+ + +
Sbjct: 252 LKILDLLEGRLIYTL 266
Score = 63.2 bits (152), Expect = 6e-10
Identities = 58/241 (24%), Positives = 97/241 (40%), Gaps = 55/241 (22%)
Query: 12 NKEPVYSLDFQ-HGTAGRIHRLASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVN 70
+K+ V S+ F HG LASA D VR+W +K GK S HT V
Sbjct: 59 HKDVVTSVQFSPHGNL-----LASASRDRTVRLWIPDKR--GK-----FSEFKAHTAPVR 106
Query: 71 VVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLE 130
V FS G+ LA+ +D I +W + + + +L H
Sbjct: 107 SVDFSADGQFLATASEDKSIKVWSMYRQR---------------------FLYSLYRHTH 145
Query: 131 DVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLS 190
V ++ DG L+ S S D T IWD + Q ++ F++ + V ++P G +A+
Sbjct: 146 WVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAG 205
Query: 191 CDRVLRVYSIQKKRVAFNVSKMLSGIGAEGEARSYRMFHDDSMKSFFRRLSFTPDGSLLL 250
D+ ++V+ ++ ++ + G+ +SF P G+ L+
Sbjct: 206 SDQTVKVWDVRVNKLLQHYQVHSGGVNC---------------------ISFHPSGNYLI 244
Query: 251 T 251
T
Sbjct: 245 T 245
Score = 47.8 bits (112), Expect = 3e-05
Identities = 28/125 (22%), Positives = 52/125 (41%), Gaps = 28/125 (22%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
+ASAG D V++W V + + L + H+ VN + F P+G L + D +
Sbjct: 201 IASAGSDQTVKVWDVR-------VNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLK 253
Query: 92 LWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDN 151
+ + + + ++ TL+GH V+ + ++ G L AS D
Sbjct: 254 ILDLLEGR---------------------LIYTLQGHTGPVFTVSFSKGGELFASGGADT 292
Query: 152 TAIIW 156
++W
Sbjct: 293 QVLLW 297
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 67.4 bits (163), Expect = 3e-11
Identities = 46/143 (32%), Positives = 67/143 (46%), Gaps = 21/143 (14%)
Query: 62 LARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTV 121
L+ H V +F P G LAS G D +ILLW V + D D
Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNV----------YGDCDN---------- 101
Query: 122 VKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDP 181
TL+GH V ++ + TDG+++ SAS D T +WD G+++ H S+V
Sbjct: 102 YATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPAR 161
Query: 182 LG-QYVATLSCDRVLRVYSIQKK 203
G Q V T S D ++++ I+KK
Sbjct: 162 RGPQLVCTGSDDGTVKLWDIRKK 184
Score = 62.8 bits (151), Expect = 8e-10
Identities = 47/180 (26%), Positives = 81/180 (45%), Gaps = 37/180 (20%)
Query: 38 DTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKVND 97
D V++W + K KA ++ N T V V F+ T + + SGG D I +W +
Sbjct: 173 DGTVKLWDIRK----KAAIQTFQN----TYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQ 224
Query: 98 NKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWD 157
NK + T+RGH + V + +++G+ + S ++DNT +WD
Sbjct: 225 NK---------------------LTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWD 263
Query: 158 V----SKGQKISIF--NEH--KSYVQGVTWDPLGQYVATLSCDRVLRVYSIQKKRVAFNV 209
V K + + IF N H + + +W P G +A S DR + V+ +R+ + +
Sbjct: 264 VRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKL 323
Score = 44.7 bits (104), Expect = 2e-04
Identities = 33/175 (18%), Positives = 69/175 (39%), Gaps = 28/175 (16%)
Query: 31 RLASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVI 90
++ S G+D ++++W + + + + H +V + S G L S D +
Sbjct: 207 QIISGGIDNDIKVWDLRQN-------KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTV 259
Query: 91 LLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHL----EDVYDICWATDGNLMAS 146
+W V E+ VK +G++ +++ W+ DG+ +A+
Sbjct: 260 RVWDVRPFAPKERC-----------------VKIFQGNVHNFEKNLLRCSWSPDGSKIAA 302
Query: 147 ASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQ 201
S D +WD + + + H + V + P + + S D+ L + IQ
Sbjct: 303 GSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
Score = 30.8 bits (68), Expect = 3.4
Identities = 18/78 (23%), Positives = 36/78 (46%), Gaps = 1/78 (1%)
Query: 122 VKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDV-SKGQKISIFNEHKSYVQGVTWD 180
+ L GH +VY + +G+ +ASA D ++W+V + H V + ++
Sbjct: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYN 118
Query: 181 PLGQYVATLSCDRVLRVY 198
G + + S D+ + V+
Sbjct: 119 TDGSMLFSASTDKTVAVW 136
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 67.0 bits (162), Expect = 4e-11
Identities = 63/254 (24%), Positives = 103/254 (40%), Gaps = 53/254 (20%)
Query: 26 AGRIHRLASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGG 85
+GR+ LA+ G D V +W + K + +L HT V VR + E++ +G
Sbjct: 32 SGRL--LATGGDDCRVNLWSINKP-------NCIMSLTGHTSPVESVRLNTPEELIVAGS 82
Query: 86 DDAVILLWKVNDNKEPEQIA----------------FQDEDEAQLNKENWTV-----VKT 124
I +W + K + F N + W + V
Sbjct: 83 QSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFR 142
Query: 125 LRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQ 184
RGH + V + ++ DG +ASA+ D+T +WD++ G+ +S F H V V + P
Sbjct: 143 YRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEY 202
Query: 185 YVATLSCDRVLRVYSIQKKRVAFNVSKMLSGIGAEGEARSYRMFHDDSMKSFFRRLSFTP 244
+A+ S DR +R + ++K +V + G G RS + F P
Sbjct: 203 LLASGSSDRTIRFWDLEKFQVVSCIE------GEPGPVRS---------------VLFNP 241
Query: 245 DGSLLLTPAGCVES 258
DG L +GC +S
Sbjct: 242 DGCCLY--SGCQDS 253
Score = 54.7 bits (130), Expect = 2e-07
Identities = 45/196 (22%), Positives = 81/196 (41%), Gaps = 43/196 (21%)
Query: 59 LSNLARHTKAVN-VVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKE 117
L + H V+ +V +G +LA+GGDD + LW + NK
Sbjct: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSI-------------------NKP 53
Query: 118 NWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGV 177
N + +L GH V + T L+ + S + +WD+ + + HK+ + +
Sbjct: 54 N--CIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSL 111
Query: 178 TWDPLGQYVATLSCDRVLRVYSIQKKRVAFNVSKMLSGIGAEGEARSYRMFHDDSMKSFF 237
+ P G++VA+ S D ++++ I++K F G +++ R
Sbjct: 112 DFHPYGEFVASGSQDTNIKLWDIRRKGCVFRY---------RGHSQAVRC---------- 152
Query: 238 RRLSFTPDGSLLLTPA 253
L F+PDG L + A
Sbjct: 153 --LRFSPDGKWLASAA 166
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 66.6 bits (161), Expect = 6e-11
Identities = 33/93 (35%), Positives = 48/93 (51%)
Query: 123 KTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPL 182
+TLRGHL +Y + W TD L+ SAS D IIWD K+ S+V + P
Sbjct: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 183 GQYVATLSCDRVLRVYSIQKKRVAFNVSKMLSG 215
G YVA D + +Y+++ + VS+ L+G
Sbjct: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAG 141
Score = 57.8 bits (138), Expect = 3e-08
Identities = 48/198 (24%), Positives = 84/198 (42%), Gaps = 27/198 (13%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
+A G+D I+ + K +G V LA HT ++ RF +I+ S GD
Sbjct: 112 VACGGLDNICSIYNL-KTREGNVRVS--RELAGHTGYLSCCRFLDDNQIVTSSGD-TTCA 167
Query: 92 LWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDN 151
LW + ++ T GH DV + A D L S + D
Sbjct: 168 LWDIETGQQ---------------------TTTFTGHTGDVMSLSLAPDTRLFVSGACDA 206
Query: 152 TAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQ--KKRVAFNV 209
+A +WDV +G F H+S + + + P G AT S D R++ ++ ++ + ++
Sbjct: 207 SAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSH 266
Query: 210 SKMLSGIGAEGEARSYRM 227
++ GI + ++S R+
Sbjct: 267 DNIICGITSVSFSKSGRL 284
Score = 43.1 bits (100), Expect = 7e-04
Identities = 37/168 (22%), Positives = 65/168 (38%), Gaps = 30/168 (17%)
Query: 34 SAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLW 93
S D + ++W V +G + H +N + F P G A+G DDA L+
Sbjct: 201 SGACDASAKLWDVREGMCRQTFTG-------HESDINAICFFPNGNAFATGSDDATCRLF 253
Query: 94 KVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTA 153
D + +++ D + + + ++ G L+ + D
Sbjct: 254 ---DLRADQELMTYSHDNI----------------ICGITSVSFSKSGRLLLAGYDDFNC 294
Query: 154 IIWDVSKGQKISIFNEHKSYVQ--GVTWDPLGQYVATLSCDRVLRVYS 199
+WD K + + H + V GVT D G VAT S D L++++
Sbjct: 295 NVWDALKADRAGVLAGHDNRVSCLGVTDD--GMAVATGSWDSFLKIWN 340
>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
[Homo sapiens]
Length = 340
Score = 65.5 bits (158), Expect = 1e-10
Identities = 33/93 (35%), Positives = 47/93 (50%)
Query: 123 KTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPL 182
+TLRGHL +Y + W TD L+ SAS D IIWD K+ S+V + P
Sbjct: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 183 GQYVATLSCDRVLRVYSIQKKRVAFNVSKMLSG 215
G +VA D + +YS++ + VS+ L G
Sbjct: 109 GNFVACGGLDNICSIYSLKTREGNVRVSRELPG 141
Score = 48.9 bits (115), Expect = 1e-05
Identities = 46/198 (23%), Positives = 79/198 (39%), Gaps = 27/198 (13%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
+A G+D I+ + K +G V L HT ++ RF +I+ S GD
Sbjct: 112 VACGGLDNICSIYSL-KTREGNVRVS--RELPGHTGYLSCCRFLDDNQIITSSGD-TTCA 167
Query: 92 LWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDN 151
LW + ++ A GH DV + A DG S + D
Sbjct: 168 LWDIETGQQTVGFA---------------------GHSGDVMSLSLAPDGRTFVSGACDA 206
Query: 152 TAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQ--KKRVAFNV 209
+ +WDV F H+S + V + P G T S D R++ ++ ++ + ++
Sbjct: 207 SIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSH 266
Query: 210 SKMLSGIGAEGEARSYRM 227
++ GI + +RS R+
Sbjct: 267 DNIICGITSVAFSRSGRL 284
Score = 46.2 bits (108), Expect = 8e-05
Identities = 40/168 (23%), Positives = 66/168 (39%), Gaps = 30/168 (17%)
Query: 34 SAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLW 93
S D ++++W V D F+ H +N V F P G +G DDA L+
Sbjct: 201 SGACDASIKLWDVR---DSMCRQTFIG----HESDINAVAFFPNGYAFTTGSDDATCRLF 253
Query: 94 KVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTA 153
D + +++ D + + + ++ G L+ + D
Sbjct: 254 ---DLRADQELLMYSHDNI----------------ICGITSVAFSRSGRLLLAGYDDFNC 294
Query: 154 IIWDVSKGQKISIFNEHKSYVQ--GVTWDPLGQYVATLSCDRVLRVYS 199
IWD KG + + H + V GVT D G VAT S D L++++
Sbjct: 295 NIWDAMKGDRAGVLAGHDNRVSCLGVTDD--GMAVATGSWDSFLKIWN 340
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 65.5 bits (158), Expect = 1e-10
Identities = 44/147 (29%), Positives = 66/147 (44%), Gaps = 22/147 (14%)
Query: 59 LSNLAR-HTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKE 117
L N+ R H V+ V P +IL S G+D LWKV L
Sbjct: 344 LKNIFRLHELPVSCVSMQPHKDILVSCGEDR---LWKV------------------LGLP 382
Query: 118 NWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGV 177
V+ T GH + + D C+ G+ +A++S D T +WD+ KG I F H V
Sbjct: 383 KCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSC 442
Query: 178 TWDPLGQYVATLSCDRVLRVYSIQKKR 204
TW G +VA+ S D+ +++ + +R
Sbjct: 443 TWHSCGNFVASSSLDKTSKIWDVNSER 469
Score = 57.0 bits (136), Expect = 4e-08
Identities = 42/167 (25%), Positives = 67/167 (40%), Gaps = 28/167 (16%)
Query: 32 LASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVIL 91
L S G D R+WKV P ++ HT ++ F P+G+ LA+ D +
Sbjct: 367 LVSCGED---RLWKVLGLPKCNVLLTGFG----HTDWLSDCCFHPSGDKLATSSGDTTVK 419
Query: 92 LWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDN 151
LW + + T GH V+ W + GN +AS+S+D
Sbjct: 420 LWDLCKGD---------------------CILTFEGHSRAVWSCTWHSCGNFVASSSLDK 458
Query: 152 TAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVY 198
T+ IWDV+ + H V + + P + T S D+ L ++
Sbjct: 459 TSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIW 505
Score = 50.1 bits (118), Expect = 5e-06
Identities = 39/172 (22%), Positives = 66/172 (38%), Gaps = 28/172 (16%)
Query: 31 RLASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVI 90
+LA++ DT V++W + KG + + H++AV + G +AS D
Sbjct: 408 KLATSSGDTTVKLWDLCKG-------DCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTS 460
Query: 91 LLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVD 150
+W VN + TL GH + V I + N + ++S D
Sbjct: 461 KIWDVNSER---------------------CRCTLYGHTDSVNSIEFFPFSNTLLTSSAD 499
Query: 151 NTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQK 202
T IWD G H + +DP G +A+ V +++ +K
Sbjct: 500 KTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRK 551
Score = 30.4 bits (67), Expect = 4.5
Identities = 14/35 (40%), Positives = 17/35 (48%)
Query: 59 LSNLARHTKAVNVVRFSPTGEILASGGDDAVILLW 93
+ L H + V FS GEIL SGG D + W
Sbjct: 596 IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,961,519
Number of Sequences: 37866
Number of extensions: 1377105
Number of successful extensions: 12400
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 328
Number of HSP's successfully gapped in prelim test: 879
Number of HSP's that attempted gapping in prelim test: 7175
Number of HSP's gapped (non-prelim): 4391
length of query: 559
length of database: 18,247,518
effective HSP length: 107
effective length of query: 452
effective length of database: 14,195,856
effective search space: 6416526912
effective search space used: 6416526912
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.