Guide to the Human Genome
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Search of human proteins with 4885065

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4885065 amyloid precursor-like protein 1 isoform 2 precursor
[Homo sapiens]
         (650 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4885065 amyloid precursor-like protein 1 isoform 2 precursor ...  1320   0.0  
gi|67782338 amyloid precursor-like protein 1 isoform 1 precursor...  1316   0.0  
gi|214010183 amyloid beta (A4) precursor-like protein 2 isoform ...   473   e-133
gi|41406057 amyloid beta A4 protein isoform c precursor [Homo sa...   442   e-124
gi|209915570 amyloid beta A4 protein isoform e precursor [Homo s...   392   e-109
gi|41406055 amyloid beta A4 protein isoform b precursor [Homo sa...   356   4e-98
gi|214010185 amyloid beta (A4) precursor-like protein 2 isoform ...   302   6e-82
gi|4502147 amyloid beta (A4) precursor-like protein 2 isoform 1 ...   302   6e-82
gi|214010181 amyloid beta (A4) precursor-like protein 2 isoform ...   302   7e-82
gi|4502167 amyloid beta A4 protein isoform a precursor [Homo sap...   254   2e-67
gi|209915573 amyloid beta A4 protein isoform f precursor [Homo s...   254   2e-67
gi|91208420 bassoon protein [Homo sapiens]                             45   3e-04
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        42   0.001
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        42   0.001
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         42   0.001
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         42   0.001
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         42   0.001
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         42   0.001
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         42   0.001
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         42   0.001
gi|22035602 mitogen-activated protein kinase kinase kinase kinas...    42   0.002
gi|138175817 zinc finger protein 236 [Homo sapiens]                    41   0.003
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa...    41   0.004
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap...    41   0.004
gi|209862789 microtubule associated monoxygenase, calponin and L...    40   0.005
gi|32484977 angiomotin like 2 [Homo sapiens]                           40   0.005
gi|33356148 formin-like 1 [Homo sapiens]                               40   0.007
gi|115648142 centrosomal protein 164kDa [Homo sapiens]                 40   0.009
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa...    39   0.011
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa...    39   0.011

>gi|4885065 amyloid precursor-like protein 1 isoform 2 precursor
           [Homo sapiens]
          Length = 650

 Score = 1320 bits (3417), Expect = 0.0
 Identities = 650/650 (100%), Positives = 650/650 (100%)

Query: 1   MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC 60
           MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC
Sbjct: 1   MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC 60

Query: 61  GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC 120
           GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC
Sbjct: 61  GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC 120

Query: 121 GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA 180
           GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA
Sbjct: 121 GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA 180

Query: 181 CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA 240
           CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA
Sbjct: 181 CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA 240

Query: 241 EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM 300
           EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM
Sbjct: 241 EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM 300

Query: 301 PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT 360
           PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT
Sbjct: 301 PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT 360

Query: 361 LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE 420
           LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE
Sbjct: 361 LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE 420

Query: 421 QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ 480
           QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ
Sbjct: 421 QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ 480

Query: 481 IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKM 540
           IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKM
Sbjct: 481 IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKM 540

Query: 541 NPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSM 600
           NPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSM
Sbjct: 541 NPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSM 600

Query: 601 LLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP 650
           LLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP
Sbjct: 601 LLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP 650


>gi|67782338 amyloid precursor-like protein 1 isoform 1 precursor
           [Homo sapiens]
          Length = 651

 Score = 1316 bits (3405), Expect = 0.0
 Identities = 650/651 (99%), Positives = 650/651 (99%), Gaps = 1/651 (0%)

Query: 1   MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC 60
           MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC
Sbjct: 1   MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC 60

Query: 61  GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC 120
           GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC
Sbjct: 61  GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC 120

Query: 121 GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA 180
           GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA
Sbjct: 121 GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA 180

Query: 181 CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA 240
           CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA
Sbjct: 181 CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA 240

Query: 241 EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM 300
           EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM
Sbjct: 241 EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM 300

Query: 301 PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT 360
           PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT
Sbjct: 301 PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT 360

Query: 361 LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE 420
           LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE
Sbjct: 361 LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE 420

Query: 421 QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ 480
           QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ
Sbjct: 421 QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ 480

Query: 481 IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKD-DTPMTLPKGSTEQDAASPEKEK 539
           IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKD DTPMTLPKGSTEQDAASPEKEK
Sbjct: 481 IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEK 540

Query: 540 MNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLS 599
           MNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLS
Sbjct: 541 MNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLS 600

Query: 600 MLLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP 650
           MLLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP
Sbjct: 601 MLLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP 651


>gi|214010183 amyloid beta (A4) precursor-like protein 2 isoform 3
           [Homo sapiens]
          Length = 695

 Score =  473 bits (1216), Expect = e-133
 Identities = 279/690 (40%), Positives = 389/690 (56%), Gaps = 77/690 (11%)

Query: 24  LPLLLLLLRAQPAIGSLAG------GSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPD 77
           L LLLL+    PA+ +LAG       + G   A    Q+A  CG+L +H +++TG+WEPD
Sbjct: 15  LLLLLLVGLTAPAL-ALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPD 73

Query: 78  PQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVP 137
           P  ++ C    + VL+YC++MYPELQI  V +A Q + ++ WC   +   C      V P
Sbjct: 74  PTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKK-QCKSRF--VTP 130

Query: 138 FRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPC 197
           F+CL GEFVS+ LLVPE C+F H+ERM+ CE+    H   +EAC +QG+ L+  GMLLPC
Sbjct: 131 FKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPC 190

Query: 198 GSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEE-----ESFPQP 252
           G D+F G EYVCCP           +G  S          E  EDEEE+       FP  
Sbjct: 191 GVDQFHGTEYVCCPQT-------KIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTE 243

Query: 253 VD--------------------------DYFVEPPQAEE--EEETVPPPSSHTLAVVG-- 282
            D                          DY+ +  + ++  EE    P S  T++     
Sbjct: 244 ADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEIT 303

Query: 283 ---KVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQS 339
              KV PTP PT+ VD+YF    + +EH  F +AK  LE R   +++ V +EW  A+ Q+
Sbjct: 304 HDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQA 363

Query: 340 KNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAAL 399
           KNLPKA+RQ L +HFQ++++ LE++ + E+Q+LVETH  RV A++ND+RR ALE +LAAL
Sbjct: 364 KNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAAL 423

Query: 400 QADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEER 459
           Q+DPP+  R+L ALRRY+RAE K++ HT+RHYQHV AVDPEKA QM+ QV THL VIEER
Sbjct: 424 QSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEER 483

Query: 460 VNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSEL-----EAPAPGGSSEDKGGLQPPD 514
            NQSL LL + P++AQE++ +I ELL  +     +      E P     S ++    PP 
Sbjct: 484 RNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPF 543

Query: 515 SKDDTPMTLPK----GSTEQDAA----------SPEKEKMNPLEQYERKVNASVPRGFPF 560
                   LP+    G  EQD            S  K   N +      V   +      
Sbjct: 544 HPFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERV 603

Query: 561 HSSEIQRDELAP--AGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVE 618
              E +R+ + P      +S  A+ GLL++     ++IV+S+++L RK+ YG ISHG+VE
Sbjct: 604 GGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVML-RKRQYGTISHGIVE 662

Query: 619 VDPMLTLEEQQLRELQRHGYENPTYRFLEE 648
           VDPMLT EE+ L ++Q HGYENPTY++LE+
Sbjct: 663 VDPMLTPEERHLNKMQNHGYENPTYKYLEQ 692


>gi|41406057 amyloid beta A4 protein isoform c precursor [Homo
           sapiens]
          Length = 695

 Score =  442 bits (1136), Expect = e-124
 Identities = 269/699 (38%), Positives = 381/699 (54%), Gaps = 80/699 (11%)

Query: 23  LLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSR 82
           +LP L LLL A     +L   + G A      Q+A  CGRL +H +++ G+W+ DP  ++
Sbjct: 1   MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60

Query: 83  RCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLP 142
            C+   + +L+YC+++YPELQI  V +A Q + ++ WC   R     HPH  V+P+RCL 
Sbjct: 61  TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHF-VIPYRCLV 119

Query: 143 GEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRF 202
           GEFVS+ALLVP+ C+FLHQERMD CE+    H  A+E CS +   LH  GMLLPCG D+F
Sbjct: 120 GEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKF 179

Query: 203 RGVEYVCCPPPGTPD--PSGTAVGDPSTRSW-------PPGSR---VEGAEDEEEEESFP 250
           RGVE+VCCP     D   S  A  D S   W         GS    VE AE+EE  E   
Sbjct: 180 RGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEE 239

Query: 251 QPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPT-----------------DG 293
           +  DD   +    E EEE   P    T       T T   T                 D 
Sbjct: 240 EEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDA 299

Query: 294 VDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEH 353
           VD Y   PG+ +EH  F +AK  LE +   ++++VMREW  A+ Q+KNLPKAD++A+ +H
Sbjct: 300 VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH 359

Query: 354 FQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLAL 413
           FQ  +++LE++ + ERQ+LVETH  RV A++ND+RR ALE ++ ALQA PP+   V   L
Sbjct: 360 FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML 419

Query: 414 RRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHL 473
           ++Y+RAEQK+++HTL+H++HV  VDP+KA Q+R QV THL+VI ER+NQSL LL   P +
Sbjct: 420 KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV 479

Query: 474 AQELRPQIQELLHSEH----------------------LGPSELEA-------PAPGGSS 504
           A+E++ ++ ELL  E                       L PS  E        P  G  S
Sbjct: 480 AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS 539

Query: 505 EDKGGLQPPDS--KDDTPM-------------TLPKGSTEQDAASPEKEKMNPLEQYERK 549
            D   LQP  S   D  P                 +G T +  +     K   + + +  
Sbjct: 540 LD--DLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMD 597

Query: 550 VNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPY 609
                  G+  H    Q+        G ++ A+ GL++ G    ++IV+++++L +KK Y
Sbjct: 598 AEFRHDSGYEVHH---QKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVML-KKKQY 653

Query: 610 GAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEE 648
            +I HGVVEVD  +T EE+ L ++Q++GYENPTY+F E+
Sbjct: 654 TSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQ 692


>gi|209915570 amyloid beta A4 protein isoform e precursor [Homo
           sapiens]
          Length = 639

 Score =  392 bits (1007), Expect = e-109
 Identities = 244/625 (39%), Positives = 339/625 (54%), Gaps = 80/625 (12%)

Query: 97  QMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGC 156
           ++YPELQI  V +A Q + ++ WC   R     HPH  V+P+RCL GEFVS+ALLVP+ C
Sbjct: 19  EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHF-VIPYRCLVGEFVSDALLVPDKC 77

Query: 157 RFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTP 216
           +FLHQERMD CE+    H  A+E CS +   LH  GMLLPCG D+FRGVE+VCCP     
Sbjct: 78  KFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEES 137

Query: 217 D--PSGTAVGDPSTRSW-------PPGSR---VEGAEDEEEEESFPQPVDDYFVEPPQAE 264
           D   S  A  D S   W         GS    VE AE+EE  E   +  DD   +    E
Sbjct: 138 DNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDE 197

Query: 265 EEEETVPPPSSHTLAVVGKVTPTPRPT-----------------DGVDIYFGMPGEISEH 307
            EEE   P    T       T T   T                 D VD Y   PG+ +EH
Sbjct: 198 VEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEH 257

Query: 308 EGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSG 367
             F +AK  LE +   ++++VMREW  A+ Q+KNLPKAD++A+ +HFQ  +++LE++ + 
Sbjct: 258 AHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAAN 317

Query: 368 ERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHT 427
           ERQ+LVETH  RV A++ND+RR ALE ++ ALQA PP+   V   L++Y+RAEQK+++HT
Sbjct: 318 ERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHT 377

Query: 428 LRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHS 487
           L+H++HV  VDP+KA Q+R QV THL+VI ER+NQSL LL   P +A+E++ ++ ELL  
Sbjct: 378 LKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQK 437

Query: 488 EH----------------------LGPSELEA-------PAPGGSSEDKGGLQPPDS--K 516
           E                       L PS  E        P  G  S D   LQP  S   
Sbjct: 438 EQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLD--DLQPWHSFGA 495

Query: 517 DDTPM-------------TLPKGSTEQDAASPEKEKMNPLEQYERKVNASVPRGFPFHSS 563
           D  P                 +G T +  +     K   + + +         G+  H  
Sbjct: 496 DSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHH- 554

Query: 564 EIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPML 623
             Q+        G ++ A+ GL++ G    ++IV+++++L +KK Y +I HGVVEVD  +
Sbjct: 555 --QKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVML-KKKQYTSIHHGVVEVDAAV 611

Query: 624 TLEEQQLRELQRHGYENPTYRFLEE 648
           T EE+ L ++Q++GYENPTY+F E+
Sbjct: 612 TPEERHLSKMQQNGYENPTYKFFEQ 636


>gi|41406055 amyloid beta A4 protein isoform b precursor [Homo
           sapiens]
          Length = 751

 Score =  356 bits (913), Expect = 4e-98
 Identities = 253/759 (33%), Positives = 361/759 (47%), Gaps = 144/759 (18%)

Query: 23  LLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSR 82
           +LP L LLL A     +L   + G A      Q+A  CGRL +H +++ G+W+ DP  ++
Sbjct: 1   MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60

Query: 83  RCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLP 142
            C+   + +L+YC+++YPELQI  V +A Q + ++ WC   R     HPH  V+P+RCL 
Sbjct: 61  TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHF-VIPYRCLV 119

Query: 143 GEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRF 202
           GEFVS+ALLVP+ C+FLHQERMD CE+    H  A+E CS +   LH  GMLLPCG D+F
Sbjct: 120 GEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKF 179

Query: 203 RGVEYVCCPPPGTPD--PSGTAVGDPSTRSW-------PPGSR---VEGAEDEEEEESFP 250
           RGVE+VCCP     D   S  A  D S   W         GS    VE AE+EE  E   
Sbjct: 180 RGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEE 239

Query: 251 QPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVD--------------- 295
           +  DD   +    E EEE   P    T       T T   T+ V+               
Sbjct: 240 EEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGP 299

Query: 296 -------IYFGMPGEISEHE---------GFLRAKMDLEERRMRQINEVMREWAMA---- 335
                   YF    +++E +         G  R   D EE  M      +   A +    
Sbjct: 300 CRAMISRWYF----DVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDA 355

Query: 336 ----------DNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ--------------- 370
                     +N+  +  KA  +   +H + + Q + E    ERQ               
Sbjct: 356 VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH 415

Query: 371 -----------------RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLAL 413
                            +LVETH  RV A++ND+RR ALE ++ ALQA PP+   V   L
Sbjct: 416 FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML 475

Query: 414 RRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHL 473
           ++Y+RAEQK+++HTL+H++HV  VDP+KA Q+R QV THL+VI ER+NQSL LL   P +
Sbjct: 476 KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV 535

Query: 474 AQELRPQIQELLHSEH----------------------LGPSELEA-------PAPGGSS 504
           A+E++ ++ ELL  E                       L PS  E        P  G  S
Sbjct: 536 AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS 595

Query: 505 EDKGGLQPPDS--KDDTPM-------------TLPKGSTEQDAASPEKEKMNPLEQYERK 549
            D   LQP  S   D  P                 +G T +  +     K   + + +  
Sbjct: 596 LD--DLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMD 653

Query: 550 VNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPY 609
                  G+  H    Q+        G ++ A+ GL++ G    ++IV+++++L +KK Y
Sbjct: 654 AEFRHDSGYEVHH---QKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVML-KKKQY 709

Query: 610 GAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEE 648
            +I HGVVEVD  +T EE+ L ++Q++GYENPTY+F E+
Sbjct: 710 TSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQ 748


>gi|214010185 amyloid beta (A4) precursor-like protein 2 isoform 4
           [Homo sapiens]
          Length = 522

 Score =  302 bits (774), Expect = 6e-82
 Identities = 171/386 (44%), Positives = 239/386 (61%), Gaps = 22/386 (5%)

Query: 284 VTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLP 343
           V PTP PT+ VD+YF    + +EH  F +AK  LE R   +++ V +EW  A+ Q+KNLP
Sbjct: 135 VPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLP 194

Query: 344 KADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADP 403
           KA+RQ L +HFQ++++ LE++ + E+Q+LVETH  RV A++ND+RR ALE +LAALQ+DP
Sbjct: 195 KAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDP 254

Query: 404 PQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQS 463
           P+  R+L ALRRY+RAE K++ HT+RHYQHV AVDPEKA QM+ QV THL VIEER NQS
Sbjct: 255 PRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQS 314

Query: 464 LGLLDQNPHLAQELRPQIQELLHSEHLGPSEL-----EAPAPGGSSEDKGGLQPPDSKDD 518
           L LL + P++AQE++ +I ELL  +     +      E P     S ++    PP     
Sbjct: 315 LSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFH 374

Query: 519 TPMTLPK----GSTEQDAA----------SPEKEKMNPLEQYERKVNASVPRGFPFHSSE 564
               LP+    G  EQD            S  K   N +      V   +         E
Sbjct: 375 PFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLE 434

Query: 565 IQRDELAP--AGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPM 622
            +R+ + P      +S  A+ GLL++     ++IV+S+++L RK+ YG ISHG+VEVDPM
Sbjct: 435 EERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVML-RKRQYGTISHGIVEVDPM 493

Query: 623 LTLEEQQLRELQRHGYENPTYRFLEE 648
           LT EE+ L ++Q HGYENPTY++LE+
Sbjct: 494 LTPEERHLNKMQNHGYENPTYKYLEQ 519



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 48/124 (38%), Positives = 70/124 (56%), Gaps = 10/124 (8%)

Query: 24  LPLLLLLLRAQPAIGSLAG------GSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPD 77
           L LLLL+    PA+ +LAG       + G   A    Q+A  CG+L +H +++TG+WEPD
Sbjct: 15  LLLLLLVGLTAPAL-ALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPD 73

Query: 78  PQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVP 137
           P  ++ C    + VL+YC++MYPELQI  V +A Q + ++ WC   R          V P
Sbjct: 74  PTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWC---RRDKKQCKSRFVTP 130

Query: 138 FRCL 141
           F+CL
Sbjct: 131 FKCL 134


>gi|4502147 amyloid beta (A4) precursor-like protein 2 isoform 1
           [Homo sapiens]
          Length = 763

 Score =  302 bits (774), Expect = 6e-82
 Identities = 172/398 (43%), Positives = 243/398 (61%), Gaps = 34/398 (8%)

Query: 284 VTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLP 343
           + PTP PT+ VD+YF    + +EH  F +AK  LE R   +++ V +EW  A+ Q+KNLP
Sbjct: 364 IPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLP 423

Query: 344 KADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADP 403
           KA+RQ L +HFQ++++ LE++ + E+Q+LVETH  RV A++ND+RR ALE +LAALQ+DP
Sbjct: 424 KAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDP 483

Query: 404 PQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQS 463
           P+  R+L ALRRY+RAE K++ HT+RHYQHV AVDPEKA QM+ QV THL VIEER NQS
Sbjct: 484 PRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQS 543

Query: 464 LGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGG------SSEDKGGLQP----- 512
           L LL + P++AQE++ +I ELL  +     +  A           SSE+   + P     
Sbjct: 544 LSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFH 603

Query: 513 -----PDSKDDT-----PMTLPKGSTEQDAA----------SPEKEKMNPLEQYERKVNA 552
                P+++D       PM    G  EQD            S  K   N +      V  
Sbjct: 604 PFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKE 663

Query: 553 SVPRGFPFHSSEIQRDELAP--AGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYG 610
            +         E +R+ + P      +S  A+ GLL++     ++IV+S+++L RK+ YG
Sbjct: 664 MIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVML-RKRQYG 722

Query: 611 AISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEE 648
            ISHG+VEVDPMLT EE+ L ++Q HGYENPTY++LE+
Sbjct: 723 TISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQ 760



 Score =  188 bits (478), Expect = 1e-47
 Identities = 104/257 (40%), Positives = 143/257 (55%), Gaps = 23/257 (8%)

Query: 24  LPLLLLLLRAQPAIGSLAG------GSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPD 77
           L LLLL+    PA+ +LAG       + G   A    Q+A  CG+L +H +++TG+WEPD
Sbjct: 15  LLLLLLVGLTAPAL-ALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPD 73

Query: 78  PQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVP 137
           P  ++ C    + VL+YC++MYPELQI  V +A Q + ++ WC   +   C      V P
Sbjct: 74  PTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKK-QCKSRF--VTP 130

Query: 138 FRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPC 197
           F+CL GEFVS+ LLVPE C+F H+ERM+ CE+    H   +EAC +QG+ L+  GMLLPC
Sbjct: 131 FKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPC 190

Query: 198 GSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEE-----ESFPQP 252
           G D+F G EYVCC       P    +G  S          E  EDEEE+       FP  
Sbjct: 191 GVDQFHGTEYVCC-------PQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTE 243

Query: 253 VD-DYFVEPPQAEEEEE 268
            D + F E    E++E+
Sbjct: 244 ADLEDFTEAAVDEDDED 260


>gi|214010181 amyloid beta (A4) precursor-like protein 2 isoform 2
           [Homo sapiens]
          Length = 751

 Score =  302 bits (773), Expect = 7e-82
 Identities = 170/386 (44%), Positives = 239/386 (61%), Gaps = 22/386 (5%)

Query: 284 VTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLP 343
           + PTP PT+ VD+YF    + +EH  F +AK  LE R   +++ V +EW  A+ Q+KNLP
Sbjct: 364 IPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLP 423

Query: 344 KADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADP 403
           KA+RQ L +HFQ++++ LE++ + E+Q+LVETH  RV A++ND+RR ALE +LAALQ+DP
Sbjct: 424 KAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDP 483

Query: 404 PQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQS 463
           P+  R+L ALRRY+RAE K++ HT+RHYQHV AVDPEKA QM+ QV THL VIEER NQS
Sbjct: 484 PRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQS 543

Query: 464 LGLLDQNPHLAQELRPQIQELLHSEHLGPSEL-----EAPAPGGSSEDKGGLQPPDSKDD 518
           L LL + P++AQE++ +I ELL  +     +      E P     S ++    PP     
Sbjct: 544 LSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFH 603

Query: 519 TPMTLPK----GSTEQDAA----------SPEKEKMNPLEQYERKVNASVPRGFPFHSSE 564
               LP+    G  EQD            S  K   N +      V   +         E
Sbjct: 604 PFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLE 663

Query: 565 IQRDELAP--AGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPM 622
            +R+ + P      +S  A+ GLL++     ++IV+S+++L RK+ YG ISHG+VEVDPM
Sbjct: 664 EERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVML-RKRQYGTISHGIVEVDPM 722

Query: 623 LTLEEQQLRELQRHGYENPTYRFLEE 648
           LT EE+ L ++Q HGYENPTY++LE+
Sbjct: 723 LTPEERHLNKMQNHGYENPTYKYLEQ 748



 Score =  188 bits (478), Expect = 1e-47
 Identities = 104/257 (40%), Positives = 143/257 (55%), Gaps = 23/257 (8%)

Query: 24  LPLLLLLLRAQPAIGSLAG------GSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPD 77
           L LLLL+    PA+ +LAG       + G   A    Q+A  CG+L +H +++TG+WEPD
Sbjct: 15  LLLLLLVGLTAPAL-ALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPD 73

Query: 78  PQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVP 137
           P  ++ C    + VL+YC++MYPELQI  V +A Q + ++ WC   +   C      V P
Sbjct: 74  PTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKK-QCKSRF--VTP 130

Query: 138 FRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPC 197
           F+CL GEFVS+ LLVPE C+F H+ERM+ CE+    H   +EAC +QG+ L+  GMLLPC
Sbjct: 131 FKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPC 190

Query: 198 GSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEE-----ESFPQP 252
           G D+F G EYVCC       P    +G  S          E  EDEEE+       FP  
Sbjct: 191 GVDQFHGTEYVCC-------PQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTE 243

Query: 253 VD-DYFVEPPQAEEEEE 268
            D + F E    E++E+
Sbjct: 244 ADLEDFTEAAVDEDDED 260


>gi|4502167 amyloid beta A4 protein isoform a precursor [Homo
           sapiens]
          Length = 770

 Score =  254 bits (648), Expect = 2e-67
 Identities = 153/401 (38%), Positives = 229/401 (57%), Gaps = 50/401 (12%)

Query: 292 DGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALN 351
           D VD Y   PG+ +EH  F +AK  LE +   ++++VMREW  A+ Q+KNLPKAD++A+ 
Sbjct: 373 DAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVI 432

Query: 352 EHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLL 411
           +HFQ  +++LE++ + ERQ+LVETH  RV A++ND+RR ALE ++ ALQA PP+   V  
Sbjct: 433 QHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFN 492

Query: 412 ALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNP 471
            L++Y+RAEQK+++HTL+H++HV  VDP+KA Q+R QV THL+VI ER+NQSL LL   P
Sbjct: 493 MLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVP 552

Query: 472 HLAQELRPQIQELLHSEH----------------------LGPSELEA-------PAPGG 502
            +A+E++ ++ ELL  E                       L PS  E        P  G 
Sbjct: 553 AVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGE 612

Query: 503 SSEDKGGLQPPDS--KDDTPM-------------TLPKGSTEQDAASPEKEKMNPLEQYE 547
            S D   LQP  S   D  P                 +G T +  +     K   + + +
Sbjct: 613 FSLD--DLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVK 670

Query: 548 RKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKK 607
                    G+  H    Q+        G ++ A+ GL++ G    ++IV+++++L +KK
Sbjct: 671 MDAEFRHDSGYEVHH---QKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVML-KKK 726

Query: 608 PYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEE 648
            Y +I HGVVEVD  +T EE+ L ++Q++GYENPTY+F E+
Sbjct: 727 QYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQ 767



 Score =  210 bits (535), Expect = 3e-54
 Identities = 157/488 (32%), Positives = 232/488 (47%), Gaps = 53/488 (10%)

Query: 23  LLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSR 82
           +LP L LLL A     +L   + G A      Q+A  CGRL +H +++ G+W+ DP  ++
Sbjct: 1   MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60

Query: 83  RCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLP 142
            C+   + +L+YC+++YPELQI  V +A Q + ++ WC   R     HPH  V+P+RCL 
Sbjct: 61  TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHF-VIPYRCLV 119

Query: 143 GEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRF 202
           GEFVS+ALLVP+ C+FLHQERMD CE+    H  A+E CS +   LH  GMLLPCG D+F
Sbjct: 120 GEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKF 179

Query: 203 RGVEYVCCPPPGTPD--PSGTAVGDPSTRSW-------PPGSR---VEGAEDEEEEESFP 250
           RGVE+VCCP     D   S  A  D S   W         GS    VE AE+EE  E   
Sbjct: 180 RGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEE 239

Query: 251 QPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGF 310
           +  DD   +    E EEE   P    T       T T   T+ V+             G 
Sbjct: 240 EEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGP 299

Query: 311 LRAKM-----DLEERRM----------RQINEVMREWAMADNQSKNLPKADRQALNEHFQ 355
            RA +     D+ E +            + N    E+ MA   S         A++   Q
Sbjct: 300 CRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGS---------AMS---Q 347

Query: 356 SILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQ-----ADPPQAERVL 410
           S+L+T +E ++ +  +L  T A+   A+         E   A  Q      +    ER+ 
Sbjct: 348 SLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMS 407

Query: 411 LALRRYLRAEQK-------EQRHTLRHYQH-VAAVDPEKAQQMRFQVHTHLQVIEERVNQ 462
             +R +  AE++       +++  ++H+Q  V +++ E A + +  V TH+  +E  +N 
Sbjct: 408 QVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLND 467

Query: 463 SLGLLDQN 470
              L  +N
Sbjct: 468 RRRLALEN 475


>gi|209915573 amyloid beta A4 protein isoform f precursor [Homo
           sapiens]
          Length = 714

 Score =  254 bits (648), Expect = 2e-67
 Identities = 153/401 (38%), Positives = 229/401 (57%), Gaps = 50/401 (12%)

Query: 292 DGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALN 351
           D VD Y   PG+ +EH  F +AK  LE +   ++++VMREW  A+ Q+KNLPKAD++A+ 
Sbjct: 317 DAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVI 376

Query: 352 EHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLL 411
           +HFQ  +++LE++ + ERQ+LVETH  RV A++ND+RR ALE ++ ALQA PP+   V  
Sbjct: 377 QHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFN 436

Query: 412 ALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNP 471
            L++Y+RAEQK+++HTL+H++HV  VDP+KA Q+R QV THL+VI ER+NQSL LL   P
Sbjct: 437 MLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVP 496

Query: 472 HLAQELRPQIQELLHSEH----------------------LGPSELEA-------PAPGG 502
            +A+E++ ++ ELL  E                       L PS  E        P  G 
Sbjct: 497 AVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGE 556

Query: 503 SSEDKGGLQPPDS--KDDTPM-------------TLPKGSTEQDAASPEKEKMNPLEQYE 547
            S D   LQP  S   D  P                 +G T +  +     K   + + +
Sbjct: 557 FSLD--DLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVK 614

Query: 548 RKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKK 607
                    G+  H    Q+        G ++ A+ GL++ G    ++IV+++++L +KK
Sbjct: 615 MDAEFRHDSGYEVHH---QKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVML-KKK 670

Query: 608 PYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEE 648
            Y +I HGVVEVD  +T EE+ L ++Q++GYENPTY+F E+
Sbjct: 671 QYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQ 711



 Score =  160 bits (406), Expect = 3e-39
 Identities = 132/414 (31%), Positives = 190/414 (45%), Gaps = 53/414 (12%)

Query: 97  QMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGC 156
           ++YPELQI  V +A Q + ++ WC   R     HPH  V+P+RCL GEFVS+ALLVP+ C
Sbjct: 19  EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHF-VIPYRCLVGEFVSDALLVPDKC 77

Query: 157 RFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTP 216
           +FLHQERMD CE+    H  A+E CS +   LH  GMLLPCG D+FRGVE+VCCP     
Sbjct: 78  KFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEES 137

Query: 217 D--PSGTAVGDPSTRSW-------PPGSR---VEGAEDEEEEESFPQPVDDYFVEPPQAE 264
           D   S  A  D S   W         GS    VE AE+EE  E   +  DD   +    E
Sbjct: 138 DNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDE 197

Query: 265 EEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKM-----DLEE 319
            EEE   P    T       T T   T+ V+             G  RA +     D+ E
Sbjct: 198 VEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTE 257

Query: 320 RRM----------RQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGER 369
            +            + N    E+ MA   S         A++   QS+L+T +E ++ + 
Sbjct: 258 GKCAPFFYGGCGGNRNNFDTEEYCMAVCGS---------AMS---QSLLKTTQEPLARDP 305

Query: 370 QRLVETHATRVIALINDQRRAALEGFLAALQ-----ADPPQAERVLLALRRYLRAEQK-- 422
            +L  T A+   A+         E   A  Q      +    ER+   +R +  AE++  
Sbjct: 306 VKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAK 365

Query: 423 -----EQRHTLRHYQH-VAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQN 470
                +++  ++H+Q  V +++ E A + +  V TH+  +E  +N    L  +N
Sbjct: 366 NLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALEN 419


>gi|91208420 bassoon protein [Homo sapiens]
          Length = 3926

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 43/172 (25%), Positives = 70/172 (40%), Gaps = 19/172 (11%)

Query: 444 QMRFQVHTHLQVIEE------RVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEA 497
           Q  F  + HL  ++E      ++ ++LG+      +    R + Q+ LHS  L P+   A
Sbjct: 200 QCGFNPNPHLTQVKEWLCLNCQMQRALGM-----DMTTAPRSKSQQQLHSPALSPAHSPA 254

Query: 498 PAPGGSSEDK-----GGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKVNA 552
             P G  + +     GG QP   + +T          Q AA PE  +++P      K + 
Sbjct: 255 KQPLGKPDQERSRGPGGPQPGSRQAETARATSVPGPAQAAAPPEVGRVSPQPPQPTKPST 314

Query: 553 SVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLL--IMGAGGGSLIVLSMLL 602
           + PR  P   +  +     PAG G + +   GL   + G G   L   S L+
Sbjct: 315 AEPRP-PAGEAPAKSATAVPAGLGATEQTQEGLTGKLFGLGASLLTQASTLM 365



 Score = 32.0 bits (71), Expect = 1.8
 Identities = 34/141 (24%), Positives = 57/141 (40%), Gaps = 11/141 (7%)

Query: 362  EEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQ 421
            EE    ERQR  +    ++     ++ R  LE        +  + ERV L   R     +
Sbjct: 2357 EEASQEERQRKQQEQLLQL-----ERERVELEKLRQLRLQEELERERVELQRHR-----E 2406

Query: 422  KEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQI 481
            +EQ    R  Q +  +     QQ + +      +  E++ Q    L+Q   L Q+L+ Q+
Sbjct: 2407 EEQLLVQRELQELQTIKHHVLQQQQEERQAQFALQREQLAQQRLQLEQIQQLQQQLQQQL 2466

Query: 482  QELLHSEHLG-PSELEAPAPG 501
            +E    +    P+  EAP  G
Sbjct: 2467 EEQKQRQKAPFPAACEAPGRG 2487



 Score = 30.4 bits (67), Expect = 5.3
 Identities = 35/114 (30%), Positives = 47/114 (41%), Gaps = 13/114 (11%)

Query: 5    SPAARGLSRRPGQP-------PLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVA 57
            +P A G SR P  P       PLP   P  +      PA   LAG  P A  APG    +
Sbjct: 2290 APGAGGPSR-PEMPVGAAREEPLPTTTPAAIKEAAGAPAPAPLAGQKPPADAAPGGG--S 2346

Query: 58   GLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQRV-LEYCRQ--MYPELQIARVE 108
            G   R    ++  +       Q+ +    + +RV LE  RQ  +  EL+  RVE
Sbjct: 2347 GALSRPGFEKEEASQEERQRKQQEQLLQLERERVELEKLRQLRLQEELERERVE 2400


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 58/242 (23%), Positives = 104/242 (42%), Gaps = 25/242 (10%)

Query: 312  RAKMDLEERRMRQ-INEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ 370
            R + D +  R+R+ I E+ RE      ++K L     Q  +E  Q++ Q   EQ+  E Q
Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLL-----QLKSEEMQTVQQ---EQLLQETQ 2489

Query: 371  RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRH 430
             L ++  +   +L+  +R      F+   +A   Q  +  +A  + LR EQ+ Q+  +  
Sbjct: 2490 ALQQSFLSEKDSLLQRER------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543

Query: 431  YQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHL 490
             +       E+A++ + +    ++  +E + Q    L+Q     +EL  +  + L  E L
Sbjct: 2544 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLR-EQL 2598

Query: 491  GPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKV 550
               E +  A    SE+    Q   +K     TLP G    D  + E E  +  +   RKV
Sbjct: 2599 QLLEEQHRAALAHSEEVTASQVAATK-----TLPNGRDALDGPAAEAEPEHSFDGLRRKV 2653

Query: 551  NA 552
            +A
Sbjct: 2654 SA 2655



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 47/194 (24%), Positives = 74/194 (38%), Gaps = 17/194 (8%)

Query: 306  EHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEE-- 363
            E E   R   +  ER  RQ+ +  +    A+ +  +  KA+ +A  E  Q  LQ LEE  
Sbjct: 1484 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELR 1542

Query: 364  -QVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQK 422
             Q     +RL +    R       Q + ALE    + +A+        L  +R   AE+ 
Sbjct: 1543 LQAEEAERRLRQAEVERA-----RQVQVALETAQRSAEAE--------LQSKRASFAEKT 1589

Query: 423  EQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQ 482
             Q       +HVA     +  + R Q     +   E   + L       + A  LR Q +
Sbjct: 1590 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1649

Query: 483  ELLHSEHLGPSELE 496
            E+   + L  +E E
Sbjct: 1650 EVAQQKSLAQAEAE 1663



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 41/160 (25%), Positives = 70/160 (43%), Gaps = 17/160 (10%)

Query: 312  RAKMDLEERRMRQINEVMR--EWAMADNQSKNLPKADRQALNEHFQSILQTLEEQV-SGE 368
            +A+ + +E + R   EV+R  E A+   Q K   + + Q L +  ++ +Q    Q  + E
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1444

Query: 369  RQRLVETHATRVIAL---INDQRRAALEGFLAAL-------QADPPQAERVLLALRRYLR 418
            R RL      RV+ L     +++R   EG L AL       +A   QA+     LRR ++
Sbjct: 1445 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1504

Query: 419  AEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEE 458
             E + +R            + E A++ +      LQ +EE
Sbjct: 1505 DESQRKRQAEVELASRVKAEAEAAREKQ----RALQALEE 1540



 Score = 33.5 bits (75), Expect = 0.63
 Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 25/204 (12%)

Query: 311  LRAKMDLEERRMRQI--NEVMREWAMADNQSKNLPKADRQA----LNEHFQSILQTLEEQ 364
            L+AK++ E RR+R+    E  R+  +A   ++   +A+ +A    + +  Q + QTL+++
Sbjct: 2014 LKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2072

Query: 365  VSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRA----- 419
             S   Q   E  A R  A   ++ R   E   A  +    +AER+  +     +A     
Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2132

Query: 420  -------EQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPH 472
                   ++ EQ    R     AA+  ++A     + H      ++   Q+L    Q   
Sbjct: 2133 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH------KKFAEQTLRQKAQVEQ 2186

Query: 473  LAQELRPQIQELLHSEHLGPSELE 496
                LR Q++E  H ++L   EL+
Sbjct: 2187 ELTTLRLQLEETDHQKNLLDEELQ 2210


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 58/242 (23%), Positives = 104/242 (42%), Gaps = 25/242 (10%)

Query: 312  RAKMDLEERRMRQ-INEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ 370
            R + D +  R+R+ I E+ RE      ++K L     Q  +E  Q++ Q   EQ+  E Q
Sbjct: 2442 RQQSDHDAERLREAIAELEREKEKLQQEAKLL-----QLKSEEMQTVQQ---EQLLQETQ 2493

Query: 371  RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRH 430
             L ++  +   +L+  +R      F+   +A   Q  +  +A  + LR EQ+ Q+  +  
Sbjct: 2494 ALQQSFLSEKDSLLQRER------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2547

Query: 431  YQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHL 490
             +       E+A++ + +    ++  +E + Q    L+Q     +EL  +  + L  E L
Sbjct: 2548 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLR-EQL 2602

Query: 491  GPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKV 550
               E +  A    SE+    Q   +K     TLP G    D  + E E  +  +   RKV
Sbjct: 2603 QLLEEQHRAALAHSEEVTASQVAATK-----TLPNGRDALDGPAAEAEPEHSFDGLRRKV 2657

Query: 551  NA 552
            +A
Sbjct: 2658 SA 2659



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 47/194 (24%), Positives = 74/194 (38%), Gaps = 17/194 (8%)

Query: 306  EHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEE-- 363
            E E   R   +  ER  RQ+ +  +    A+ +  +  KA+ +A  E  Q  LQ LEE  
Sbjct: 1488 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELR 1546

Query: 364  -QVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQK 422
             Q     +RL +    R       Q + ALE    + +A+        L  +R   AE+ 
Sbjct: 1547 LQAEEAERRLRQAEVERA-----RQVQVALETAQRSAEAE--------LQSKRASFAEKT 1593

Query: 423  EQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQ 482
             Q       +HVA     +  + R Q     +   E   + L       + A  LR Q +
Sbjct: 1594 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1653

Query: 483  ELLHSEHLGPSELE 496
            E+   + L  +E E
Sbjct: 1654 EVAQQKSLAQAEAE 1667



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 41/160 (25%), Positives = 70/160 (43%), Gaps = 17/160 (10%)

Query: 312  RAKMDLEERRMRQINEVMR--EWAMADNQSKNLPKADRQALNEHFQSILQTLEEQV-SGE 368
            +A+ + +E + R   EV+R  E A+   Q K   + + Q L +  ++ +Q    Q  + E
Sbjct: 1389 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1448

Query: 369  RQRLVETHATRVIAL---INDQRRAALEGFLAAL-------QADPPQAERVLLALRRYLR 418
            R RL      RV+ L     +++R   EG L AL       +A   QA+     LRR ++
Sbjct: 1449 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1508

Query: 419  AEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEE 458
             E + +R            + E A++ +      LQ +EE
Sbjct: 1509 DESQRKRQAEVELASRVKAEAEAAREKQ----RALQALEE 1544



 Score = 33.5 bits (75), Expect = 0.63
 Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 25/204 (12%)

Query: 311  LRAKMDLEERRMRQI--NEVMREWAMADNQSKNLPKADRQA----LNEHFQSILQTLEEQ 364
            L+AK++ E RR+R+    E  R+  +A   ++   +A+ +A    + +  Q + QTL+++
Sbjct: 2018 LKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2076

Query: 365  VSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRA----- 419
             S   Q   E  A R  A   ++ R   E   A  +    +AER+  +     +A     
Sbjct: 2077 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2136

Query: 420  -------EQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPH 472
                   ++ EQ    R     AA+  ++A     + H      ++   Q+L    Q   
Sbjct: 2137 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH------KKFAEQTLRQKAQVEQ 2190

Query: 473  LAQELRPQIQELLHSEHLGPSELE 496
                LR Q++E  H ++L   EL+
Sbjct: 2191 ELTTLRLQLEETDHQKNLLDEELQ 2214


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 58/242 (23%), Positives = 104/242 (42%), Gaps = 25/242 (10%)

Query: 312  RAKMDLEERRMRQ-INEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ 370
            R + D +  R+R+ I E+ RE      ++K L     Q  +E  Q++ Q   EQ+  E Q
Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLL-----QLKSEEMQTVQQ---EQLLQETQ 2489

Query: 371  RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRH 430
             L ++  +   +L+  +R      F+   +A   Q  +  +A  + LR EQ+ Q+  +  
Sbjct: 2490 ALQQSFLSEKDSLLQRER------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543

Query: 431  YQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHL 490
             +       E+A++ + +    ++  +E + Q    L+Q     +EL  +  + L  E L
Sbjct: 2544 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLR-EQL 2598

Query: 491  GPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKV 550
               E +  A    SE+    Q   +K     TLP G    D  + E E  +  +   RKV
Sbjct: 2599 QLLEEQHRAALAHSEEVTASQVAATK-----TLPNGRDALDGPAAEAEPEHSFDGLRRKV 2653

Query: 551  NA 552
            +A
Sbjct: 2654 SA 2655



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 47/194 (24%), Positives = 74/194 (38%), Gaps = 17/194 (8%)

Query: 306  EHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEE-- 363
            E E   R   +  ER  RQ+ +  +    A+ +  +  KA+ +A  E  Q  LQ LEE  
Sbjct: 1484 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELR 1542

Query: 364  -QVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQK 422
             Q     +RL +    R       Q + ALE    + +A+        L  +R   AE+ 
Sbjct: 1543 LQAEEAERRLRQAEVERA-----RQVQVALETAQRSAEAE--------LQSKRASFAEKT 1589

Query: 423  EQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQ 482
             Q       +HVA     +  + R Q     +   E   + L       + A  LR Q +
Sbjct: 1590 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1649

Query: 483  ELLHSEHLGPSELE 496
            E+   + L  +E E
Sbjct: 1650 EVAQQKSLAQAEAE 1663



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 41/160 (25%), Positives = 70/160 (43%), Gaps = 17/160 (10%)

Query: 312  RAKMDLEERRMRQINEVMR--EWAMADNQSKNLPKADRQALNEHFQSILQTLEEQV-SGE 368
            +A+ + +E + R   EV+R  E A+   Q K   + + Q L +  ++ +Q    Q  + E
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1444

Query: 369  RQRLVETHATRVIAL---INDQRRAALEGFLAAL-------QADPPQAERVLLALRRYLR 418
            R RL      RV+ L     +++R   EG L AL       +A   QA+     LRR ++
Sbjct: 1445 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1504

Query: 419  AEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEE 458
             E + +R            + E A++ +      LQ +EE
Sbjct: 1505 DESQRKRQAEVELASRVKAEAEAAREKQ----RALQALEE 1540



 Score = 33.5 bits (75), Expect = 0.63
 Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 25/204 (12%)

Query: 311  LRAKMDLEERRMRQI--NEVMREWAMADNQSKNLPKADRQA----LNEHFQSILQTLEEQ 364
            L+AK++ E RR+R+    E  R+  +A   ++   +A+ +A    + +  Q + QTL+++
Sbjct: 2014 LKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2072

Query: 365  VSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRA----- 419
             S   Q   E  A R  A   ++ R   E   A  +    +AER+  +     +A     
Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2132

Query: 420  -------EQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPH 472
                   ++ EQ    R     AA+  ++A     + H      ++   Q+L    Q   
Sbjct: 2133 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH------KKFAEQTLRQKAQVEQ 2186

Query: 473  LAQELRPQIQELLHSEHLGPSELE 496
                LR Q++E  H ++L   EL+
Sbjct: 2187 ELTTLRLQLEETDHQKNLLDEELQ 2210


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 58/242 (23%), Positives = 104/242 (42%), Gaps = 25/242 (10%)

Query: 312  RAKMDLEERRMRQ-INEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ 370
            R + D +  R+R+ I E+ RE      ++K L     Q  +E  Q++ Q   EQ+  E Q
Sbjct: 2406 RQQSDHDAERLREAIAELEREKEKLQQEAKLL-----QLKSEEMQTVQQ---EQLLQETQ 2457

Query: 371  RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRH 430
             L ++  +   +L+  +R      F+   +A   Q  +  +A  + LR EQ+ Q+  +  
Sbjct: 2458 ALQQSFLSEKDSLLQRER------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2511

Query: 431  YQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHL 490
             +       E+A++ + +    ++  +E + Q    L+Q     +EL  +  + L  E L
Sbjct: 2512 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLR-EQL 2566

Query: 491  GPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKV 550
               E +  A    SE+    Q   +K     TLP G    D  + E E  +  +   RKV
Sbjct: 2567 QLLEEQHRAALAHSEEVTASQVAATK-----TLPNGRDALDGPAAEAEPEHSFDGLRRKV 2621

Query: 551  NA 552
            +A
Sbjct: 2622 SA 2623



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 47/194 (24%), Positives = 74/194 (38%), Gaps = 17/194 (8%)

Query: 306  EHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEE-- 363
            E E   R   +  ER  RQ+ +  +    A+ +  +  KA+ +A  E  Q  LQ LEE  
Sbjct: 1452 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELR 1510

Query: 364  -QVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQK 422
             Q     +RL +    R       Q + ALE    + +A+        L  +R   AE+ 
Sbjct: 1511 LQAEEAERRLRQAEVERA-----RQVQVALETAQRSAEAE--------LQSKRASFAEKT 1557

Query: 423  EQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQ 482
             Q       +HVA     +  + R Q     +   E   + L       + A  LR Q +
Sbjct: 1558 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1617

Query: 483  ELLHSEHLGPSELE 496
            E+   + L  +E E
Sbjct: 1618 EVAQQKSLAQAEAE 1631



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 41/160 (25%), Positives = 70/160 (43%), Gaps = 17/160 (10%)

Query: 312  RAKMDLEERRMRQINEVMR--EWAMADNQSKNLPKADRQALNEHFQSILQTLEEQV-SGE 368
            +A+ + +E + R   EV+R  E A+   Q K   + + Q L +  ++ +Q    Q  + E
Sbjct: 1353 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1412

Query: 369  RQRLVETHATRVIAL---INDQRRAALEGFLAAL-------QADPPQAERVLLALRRYLR 418
            R RL      RV+ L     +++R   EG L AL       +A   QA+     LRR ++
Sbjct: 1413 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1472

Query: 419  AEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEE 458
             E + +R            + E A++ +      LQ +EE
Sbjct: 1473 DESQRKRQAEVELASRVKAEAEAAREKQ----RALQALEE 1508



 Score = 33.5 bits (75), Expect = 0.63
 Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 25/204 (12%)

Query: 311  LRAKMDLEERRMRQI--NEVMREWAMADNQSKNLPKADRQA----LNEHFQSILQTLEEQ 364
            L+AK++ E RR+R+    E  R+  +A   ++   +A+ +A    + +  Q + QTL+++
Sbjct: 1982 LKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2040

Query: 365  VSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRA----- 419
             S   Q   E  A R  A   ++ R   E   A  +    +AER+  +     +A     
Sbjct: 2041 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2100

Query: 420  -------EQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPH 472
                   ++ EQ    R     AA+  ++A     + H      ++   Q+L    Q   
Sbjct: 2101 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH------KKFAEQTLRQKAQVEQ 2154

Query: 473  LAQELRPQIQELLHSEHLGPSELE 496
                LR Q++E  H ++L   EL+
Sbjct: 2155 ELTTLRLQLEETDHQKNLLDEELQ 2178


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 58/242 (23%), Positives = 104/242 (42%), Gaps = 25/242 (10%)

Query: 312  RAKMDLEERRMRQ-INEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ 370
            R + D +  R+R+ I E+ RE      ++K L     Q  +E  Q++ Q   EQ+  E Q
Sbjct: 2575 RQQSDHDAERLREAIAELEREKEKLQQEAKLL-----QLKSEEMQTVQQ---EQLLQETQ 2626

Query: 371  RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRH 430
             L ++  +   +L+  +R      F+   +A   Q  +  +A  + LR EQ+ Q+  +  
Sbjct: 2627 ALQQSFLSEKDSLLQRER------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2680

Query: 431  YQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHL 490
             +       E+A++ + +    ++  +E + Q    L+Q     +EL  +  + L  E L
Sbjct: 2681 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLR-EQL 2735

Query: 491  GPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKV 550
               E +  A    SE+    Q   +K     TLP G    D  + E E  +  +   RKV
Sbjct: 2736 QLLEEQHRAALAHSEEVTASQVAATK-----TLPNGRDALDGPAAEAEPEHSFDGLRRKV 2790

Query: 551  NA 552
            +A
Sbjct: 2791 SA 2792



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 47/194 (24%), Positives = 74/194 (38%), Gaps = 17/194 (8%)

Query: 306  EHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEE-- 363
            E E   R   +  ER  RQ+ +  +    A+ +  +  KA+ +A  E  Q  LQ LEE  
Sbjct: 1621 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELR 1679

Query: 364  -QVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQK 422
             Q     +RL +    R       Q + ALE    + +A+        L  +R   AE+ 
Sbjct: 1680 LQAEEAERRLRQAEVERA-----RQVQVALETAQRSAEAE--------LQSKRASFAEKT 1726

Query: 423  EQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQ 482
             Q       +HVA     +  + R Q     +   E   + L       + A  LR Q +
Sbjct: 1727 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1786

Query: 483  ELLHSEHLGPSELE 496
            E+   + L  +E E
Sbjct: 1787 EVAQQKSLAQAEAE 1800



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 41/160 (25%), Positives = 70/160 (43%), Gaps = 17/160 (10%)

Query: 312  RAKMDLEERRMRQINEVMR--EWAMADNQSKNLPKADRQALNEHFQSILQTLEEQV-SGE 368
            +A+ + +E + R   EV+R  E A+   Q K   + + Q L +  ++ +Q    Q  + E
Sbjct: 1522 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1581

Query: 369  RQRLVETHATRVIAL---INDQRRAALEGFLAAL-------QADPPQAERVLLALRRYLR 418
            R RL      RV+ L     +++R   EG L AL       +A   QA+     LRR ++
Sbjct: 1582 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1641

Query: 419  AEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEE 458
             E + +R            + E A++ +      LQ +EE
Sbjct: 1642 DESQRKRQAEVELASRVKAEAEAAREKQ----RALQALEE 1677



 Score = 33.5 bits (75), Expect = 0.63
 Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 25/204 (12%)

Query: 311  LRAKMDLEERRMRQI--NEVMREWAMADNQSKNLPKADRQA----LNEHFQSILQTLEEQ 364
            L+AK++ E RR+R+    E  R+  +A   ++   +A+ +A    + +  Q + QTL+++
Sbjct: 2151 LKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2209

Query: 365  VSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRA----- 419
             S   Q   E  A R  A   ++ R   E   A  +    +AER+  +     +A     
Sbjct: 2210 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2269

Query: 420  -------EQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPH 472
                   ++ EQ    R     AA+  ++A     + H      ++   Q+L    Q   
Sbjct: 2270 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH------KKFAEQTLRQKAQVEQ 2323

Query: 473  LAQELRPQIQELLHSEHLGPSELE 496
                LR Q++E  H ++L   EL+
Sbjct: 2324 ELTTLRLQLEETDHQKNLLDEELQ 2347


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 58/242 (23%), Positives = 104/242 (42%), Gaps = 25/242 (10%)

Query: 312  RAKMDLEERRMRQ-INEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ 370
            R + D +  R+R+ I E+ RE      ++K L     Q  +E  Q++ Q   EQ+  E Q
Sbjct: 2416 RQQSDHDAERLREAIAELEREKEKLQQEAKLL-----QLKSEEMQTVQQ---EQLLQETQ 2467

Query: 371  RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRH 430
             L ++  +   +L+  +R      F+   +A   Q  +  +A  + LR EQ+ Q+  +  
Sbjct: 2468 ALQQSFLSEKDSLLQRER------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2521

Query: 431  YQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHL 490
             +       E+A++ + +    ++  +E + Q    L+Q     +EL  +  + L  E L
Sbjct: 2522 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLR-EQL 2576

Query: 491  GPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKV 550
               E +  A    SE+    Q   +K     TLP G    D  + E E  +  +   RKV
Sbjct: 2577 QLLEEQHRAALAHSEEVTASQVAATK-----TLPNGRDALDGPAAEAEPEHSFDGLRRKV 2631

Query: 551  NA 552
            +A
Sbjct: 2632 SA 2633



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 47/194 (24%), Positives = 74/194 (38%), Gaps = 17/194 (8%)

Query: 306  EHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEE-- 363
            E E   R   +  ER  RQ+ +  +    A+ +  +  KA+ +A  E  Q  LQ LEE  
Sbjct: 1462 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELR 1520

Query: 364  -QVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQK 422
             Q     +RL +    R       Q + ALE    + +A+        L  +R   AE+ 
Sbjct: 1521 LQAEEAERRLRQAEVERA-----RQVQVALETAQRSAEAE--------LQSKRASFAEKT 1567

Query: 423  EQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQ 482
             Q       +HVA     +  + R Q     +   E   + L       + A  LR Q +
Sbjct: 1568 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1627

Query: 483  ELLHSEHLGPSELE 496
            E+   + L  +E E
Sbjct: 1628 EVAQQKSLAQAEAE 1641



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 41/160 (25%), Positives = 70/160 (43%), Gaps = 17/160 (10%)

Query: 312  RAKMDLEERRMRQINEVMR--EWAMADNQSKNLPKADRQALNEHFQSILQTLEEQV-SGE 368
            +A+ + +E + R   EV+R  E A+   Q K   + + Q L +  ++ +Q    Q  + E
Sbjct: 1363 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1422

Query: 369  RQRLVETHATRVIAL---INDQRRAALEGFLAAL-------QADPPQAERVLLALRRYLR 418
            R RL      RV+ L     +++R   EG L AL       +A   QA+     LRR ++
Sbjct: 1423 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1482

Query: 419  AEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEE 458
             E + +R            + E A++ +      LQ +EE
Sbjct: 1483 DESQRKRQAEVELASRVKAEAEAAREKQ----RALQALEE 1518



 Score = 33.5 bits (75), Expect = 0.63
 Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 25/204 (12%)

Query: 311  LRAKMDLEERRMRQI--NEVMREWAMADNQSKNLPKADRQA----LNEHFQSILQTLEEQ 364
            L+AK++ E RR+R+    E  R+  +A   ++   +A+ +A    + +  Q + QTL+++
Sbjct: 1992 LKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2050

Query: 365  VSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRA----- 419
             S   Q   E  A R  A   ++ R   E   A  +    +AER+  +     +A     
Sbjct: 2051 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2110

Query: 420  -------EQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPH 472
                   ++ EQ    R     AA+  ++A     + H      ++   Q+L    Q   
Sbjct: 2111 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH------KKFAEQTLRQKAQVEQ 2164

Query: 473  LAQELRPQIQELLHSEHLGPSELE 496
                LR Q++E  H ++L   EL+
Sbjct: 2165 ELTTLRLQLEETDHQKNLLDEELQ 2188


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 58/242 (23%), Positives = 104/242 (42%), Gaps = 25/242 (10%)

Query: 312  RAKMDLEERRMRQ-INEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ 370
            R + D +  R+R+ I E+ RE      ++K L     Q  +E  Q++ Q   EQ+  E Q
Sbjct: 2424 RQQSDHDAERLREAIAELEREKEKLQQEAKLL-----QLKSEEMQTVQQ---EQLLQETQ 2475

Query: 371  RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRH 430
             L ++  +   +L+  +R      F+   +A   Q  +  +A  + LR EQ+ Q+  +  
Sbjct: 2476 ALQQSFLSEKDSLLQRER------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2529

Query: 431  YQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHL 490
             +       E+A++ + +    ++  +E + Q    L+Q     +EL  +  + L  E L
Sbjct: 2530 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLR-EQL 2584

Query: 491  GPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKV 550
               E +  A    SE+    Q   +K     TLP G    D  + E E  +  +   RKV
Sbjct: 2585 QLLEEQHRAALAHSEEVTASQVAATK-----TLPNGRDALDGPAAEAEPEHSFDGLRRKV 2639

Query: 551  NA 552
            +A
Sbjct: 2640 SA 2641



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 47/194 (24%), Positives = 74/194 (38%), Gaps = 17/194 (8%)

Query: 306  EHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEE-- 363
            E E   R   +  ER  RQ+ +  +    A+ +  +  KA+ +A  E  Q  LQ LEE  
Sbjct: 1470 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELR 1528

Query: 364  -QVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQK 422
             Q     +RL +    R       Q + ALE    + +A+        L  +R   AE+ 
Sbjct: 1529 LQAEEAERRLRQAEVERA-----RQVQVALETAQRSAEAE--------LQSKRASFAEKT 1575

Query: 423  EQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQ 482
             Q       +HVA     +  + R Q     +   E   + L       + A  LR Q +
Sbjct: 1576 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1635

Query: 483  ELLHSEHLGPSELE 496
            E+   + L  +E E
Sbjct: 1636 EVAQQKSLAQAEAE 1649



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 41/160 (25%), Positives = 70/160 (43%), Gaps = 17/160 (10%)

Query: 312  RAKMDLEERRMRQINEVMR--EWAMADNQSKNLPKADRQALNEHFQSILQTLEEQV-SGE 368
            +A+ + +E + R   EV+R  E A+   Q K   + + Q L +  ++ +Q    Q  + E
Sbjct: 1371 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1430

Query: 369  RQRLVETHATRVIAL---INDQRRAALEGFLAAL-------QADPPQAERVLLALRRYLR 418
            R RL      RV+ L     +++R   EG L AL       +A   QA+     LRR ++
Sbjct: 1431 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1490

Query: 419  AEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEE 458
             E + +R            + E A++ +      LQ +EE
Sbjct: 1491 DESQRKRQAEVELASRVKAEAEAAREKQ----RALQALEE 1526



 Score = 33.5 bits (75), Expect = 0.63
 Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 25/204 (12%)

Query: 311  LRAKMDLEERRMRQI--NEVMREWAMADNQSKNLPKADRQA----LNEHFQSILQTLEEQ 364
            L+AK++ E RR+R+    E  R+  +A   ++   +A+ +A    + +  Q + QTL+++
Sbjct: 2000 LKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2058

Query: 365  VSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRA----- 419
             S   Q   E  A R  A   ++ R   E   A  +    +AER+  +     +A     
Sbjct: 2059 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2118

Query: 420  -------EQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPH 472
                   ++ EQ    R     AA+  ++A     + H      ++   Q+L    Q   
Sbjct: 2119 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH------KKFAEQTLRQKAQVEQ 2172

Query: 473  LAQELRPQIQELLHSEHLGPSELE 496
                LR Q++E  H ++L   EL+
Sbjct: 2173 ELTTLRLQLEETDHQKNLLDEELQ 2196


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 58/242 (23%), Positives = 104/242 (42%), Gaps = 25/242 (10%)

Query: 312  RAKMDLEERRMRQ-INEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ 370
            R + D +  R+R+ I E+ RE      ++K L     Q  +E  Q++ Q   EQ+  E Q
Sbjct: 2465 RQQSDHDAERLREAIAELEREKEKLQQEAKLL-----QLKSEEMQTVQQ---EQLLQETQ 2516

Query: 371  RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRH 430
             L ++  +   +L+  +R      F+   +A   Q  +  +A  + LR EQ+ Q+  +  
Sbjct: 2517 ALQQSFLSEKDSLLQRER------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2570

Query: 431  YQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHL 490
             +       E+A++ + +    ++  +E + Q    L+Q     +EL  +  + L  E L
Sbjct: 2571 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLR-EQL 2625

Query: 491  GPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKV 550
               E +  A    SE+    Q   +K     TLP G    D  + E E  +  +   RKV
Sbjct: 2626 QLLEEQHRAALAHSEEVTASQVAATK-----TLPNGRDALDGPAAEAEPEHSFDGLRRKV 2680

Query: 551  NA 552
            +A
Sbjct: 2681 SA 2682



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 47/194 (24%), Positives = 74/194 (38%), Gaps = 17/194 (8%)

Query: 306  EHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEE-- 363
            E E   R   +  ER  RQ+ +  +    A+ +  +  KA+ +A  E  Q  LQ LEE  
Sbjct: 1511 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELR 1569

Query: 364  -QVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQK 422
             Q     +RL +    R       Q + ALE    + +A+        L  +R   AE+ 
Sbjct: 1570 LQAEEAERRLRQAEVERA-----RQVQVALETAQRSAEAE--------LQSKRASFAEKT 1616

Query: 423  EQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQ 482
             Q       +HVA     +  + R Q     +   E   + L       + A  LR Q +
Sbjct: 1617 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1676

Query: 483  ELLHSEHLGPSELE 496
            E+   + L  +E E
Sbjct: 1677 EVAQQKSLAQAEAE 1690



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 41/160 (25%), Positives = 70/160 (43%), Gaps = 17/160 (10%)

Query: 312  RAKMDLEERRMRQINEVMR--EWAMADNQSKNLPKADRQALNEHFQSILQTLEEQV-SGE 368
            +A+ + +E + R   EV+R  E A+   Q K   + + Q L +  ++ +Q    Q  + E
Sbjct: 1412 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1471

Query: 369  RQRLVETHATRVIAL---INDQRRAALEGFLAAL-------QADPPQAERVLLALRRYLR 418
            R RL      RV+ L     +++R   EG L AL       +A   QA+     LRR ++
Sbjct: 1472 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1531

Query: 419  AEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEE 458
             E + +R            + E A++ +      LQ +EE
Sbjct: 1532 DESQRKRQAEVELASRVKAEAEAAREKQ----RALQALEE 1567



 Score = 33.5 bits (75), Expect = 0.63
 Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 25/204 (12%)

Query: 311  LRAKMDLEERRMRQI--NEVMREWAMADNQSKNLPKADRQA----LNEHFQSILQTLEEQ 364
            L+AK++ E RR+R+    E  R+  +A   ++   +A+ +A    + +  Q + QTL+++
Sbjct: 2041 LKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2099

Query: 365  VSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRA----- 419
             S   Q   E  A R  A   ++ R   E   A  +    +AER+  +     +A     
Sbjct: 2100 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2159

Query: 420  -------EQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPH 472
                   ++ EQ    R     AA+  ++A     + H      ++   Q+L    Q   
Sbjct: 2160 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH------KKFAEQTLRQKAQVEQ 2213

Query: 473  LAQELRPQIQELLHSEHLGPSELE 496
                LR Q++E  H ++L   EL+
Sbjct: 2214 ELTTLRLQLEETDHQKNLLDEELQ 2237


>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 1 [Homo sapiens]
          Length = 1166

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 73/327 (22%), Positives = 125/327 (38%), Gaps = 77/327 (23%)

Query: 254 DDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRA 313
           D+   E   +EEEEE VP       ++V                  +PGE +    FLR 
Sbjct: 317 DETEYEYSGSEEEEEEVPEQEGEPSSIVN-----------------VPGESTLRRDFLRL 359

Query: 314 KMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLV 373
           + + +ER     +E +R                +Q L E      +  + Q+  ERQ+ +
Sbjct: 360 QQENKER-----SEALRR---------------QQLLQEQQLREQEEYKRQLLAERQKRI 399

Query: 374 ETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRY----LRAEQKEQRHTLR 429
           E    +   L   QRR       A  Q +  Q  R     RR      R +++E+R    
Sbjct: 400 EQQKEQRRRLEEQQRRER----EARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAE 455

Query: 430 HYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEH 489
             +     + E  ++   +   HL+V+++++ Q   +L     L    RP  Q   HS+ 
Sbjct: 456 EEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAML-----LHDHRRPHPQ---HSQQ 507

Query: 490 LGPSELEAPAPG-GSSEDKGGLQPPD----------------SKDDTPMTLPKGSTEQDA 532
             P + E   P   + E K   +P D                S+ D+P+   +GS +Q++
Sbjct: 508 PPPPQQERSKPSFHAPEPKAHYEPADRAREVPVRTTSRSPVLSRRDSPL---QGSGQQNS 564

Query: 533 ASPEKEKMNPLEQ---YERKVNASVPR 556
            + ++   + +E    +ER V   VPR
Sbjct: 565 QAGQRNSTSSIEPRLLWER-VEKLVPR 590


>gi|138175817 zinc finger protein 236 [Homo sapiens]
          Length = 1845

 Score = 41.2 bits (95), Expect = 0.003
 Identities = 40/165 (24%), Positives = 74/165 (44%), Gaps = 23/165 (13%)

Query: 411 LALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQV-IE-ERVNQSLGLLD 468
           L  +++++  + E    L+ +Q  A++D     Q   Q  T +QV IE + + Q+  ++ 
Sbjct: 754 LNCKKHMKTHRYELAQQLQQHQQAASIDDSTVDQQSMQASTQMQVEIESDELPQTAEVVA 813

Query: 469 QNPHLAQELRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGST 528
            NP    +L P  Q ++ +E  G  +  A  P  + ED G + P D     P+   +G  
Sbjct: 814 ANPEAMLDLEP--QHVVGTEEAGLGQQLADQPLEADED-GFVAPQD-----PL---RGHV 862

Query: 529 EQ-DAASPEKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAP 572
           +Q +  SP ++   P         A +P+GF    +  Q+ +  P
Sbjct: 863 DQFEEQSPAQQSFEP---------AGLPQGFTVTDTYHQQPQFPP 898


>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
           sapiens]
          Length = 1352

 Score = 40.8 bits (94), Expect = 0.004
 Identities = 56/219 (25%), Positives = 92/219 (42%), Gaps = 17/219 (7%)

Query: 300 MPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQ 359
           +PGE +    FLR ++  +ER     +E +R   +   Q +N  +  RQ L E  + I  
Sbjct: 344 LPGESTLRRDFLRLQLANKER-----SEALRRQQLEQQQREN-EEHKRQLLAERQKRI-- 395

Query: 360 TLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPP--QAERVLLALRRYL 417
             EEQ   E++R +E    R   L   Q R     +   ++ +    +AE     +RR L
Sbjct: 396 --EEQ--KEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQL 451

Query: 418 RAEQKEQRHTLRHYQHVAAVDPE-KAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQE 476
             EQ++     +   H  A+  E K +Q+  Q     + ++ ++ Q    L    H  QE
Sbjct: 452 EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQ--RQAERLQRQLKQERDYLVSLQHQRQE 509

Query: 477 LRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDS 515
            RP  ++ L+    G S  E PA     E++  L    S
Sbjct: 510 QRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSS 548


>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
           sapiens]
          Length = 1360

 Score = 40.8 bits (94), Expect = 0.004
 Identities = 56/219 (25%), Positives = 92/219 (42%), Gaps = 17/219 (7%)

Query: 300 MPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQ 359
           +PGE +    FLR ++  +ER     +E +R   +   Q +N  +  RQ L E  + I  
Sbjct: 344 LPGESTLRRDFLRLQLANKER-----SEALRRQQLEQQQREN-EEHKRQLLAERQKRI-- 395

Query: 360 TLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPP--QAERVLLALRRYL 417
             EEQ   E++R +E    R   L   Q R     +   ++ +    +AE     +RR L
Sbjct: 396 --EEQ--KEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQL 451

Query: 418 RAEQKEQRHTLRHYQHVAAVDPE-KAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQE 476
             EQ++     +   H  A+  E K +Q+  Q     + ++ ++ Q    L    H  QE
Sbjct: 452 EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQ--RQAERLQRQLKQERDYLVSLQHQRQE 509

Query: 477 LRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDS 515
            RP  ++ L+    G S  E PA     E++  L    S
Sbjct: 510 QRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSS 548


>gi|209862789 microtubule associated monoxygenase, calponin and LIM
            domain containing 3 isoform 1 [Homo sapiens]
          Length = 2002

 Score = 40.4 bits (93), Expect = 0.005
 Identities = 38/137 (27%), Positives = 52/137 (37%), Gaps = 11/137 (8%)

Query: 175  QEAQEACSSQGLILHGSGM-LLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPP 233
            +E +E  SS GL LHGS   +   GS  F   +     PP +P P      +P+T     
Sbjct: 1417 EERRELSSSSGLGLHGSSSNMKTLGSQSFNTSDSAMLTPPSSPPPPPPPGEEPAT----- 1471

Query: 234  GSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDG 293
              R +  E E      P P+   ++ PP+    E   PP      + V  V   P   D 
Sbjct: 1472 -LRRKLREAEPNASVVPPPLPATWMRPPR----EPAQPPREEVRKSFVESVEEIPFADDV 1526

Query: 294  VDIYFGMPGEISEHEGF 310
             D Y     + S  E F
Sbjct: 1527 EDTYDDKTEDSSLQEKF 1543


>gi|32484977 angiomotin like 2 [Homo sapiens]
          Length = 780

 Score = 40.4 bits (93), Expect = 0.005
 Identities = 53/205 (25%), Positives = 83/205 (40%), Gaps = 42/205 (20%)

Query: 308 EGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHF--QSILQTLEEQV 365
           E  +R KMD E RR++  N  +RE   + N+       + QA ++    + + Q+ E+Q 
Sbjct: 373 EKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQ- 431

Query: 366 SGERQRLVETHATRVIALINDQRRAA--LEGFLAALQADPPQAERVLLALRRYLRAEQKE 423
             + Q  +E     +   I DQRR A  LE  L   Q    +AE  L   + Y+   ++ 
Sbjct: 432 --QEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERL 489

Query: 424 QRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQE 483
           Q+  L   Q       EK +Q+  ++ T L+                    QEL+     
Sbjct: 490 QQ-ALGQLQAAC----EKREQLELRLRTRLE--------------------QELKA---- 520

Query: 484 LLHSEHLGPSELEAPAPGGSSEDKG 508
                 L   + +A APGGSS   G
Sbjct: 521 ------LRAQQRQAGAPGGSSGSGG 539


>gi|33356148 formin-like 1 [Homo sapiens]
          Length = 1100

 Score = 40.0 bits (92), Expect = 0.007
 Identities = 69/300 (23%), Positives = 114/300 (38%), Gaps = 44/300 (14%)

Query: 211 PPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETV 270
           PPP  P P     G PS +  PP +  +        E  P P     + PP         
Sbjct: 542 PPPPPPLP-----GLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPP------ 590

Query: 271 PPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFL----RAKMDLEER-RMRQI 325
           PPP   T   V    P P P  G     G P  +   +  L    +AK  ++ + RM  +
Sbjct: 591 PPPPPGTDGPVPPPPPPPPPPPG-----GPPDALGRRDSELGPGVKAKKPIQTKFRMPLL 645

Query: 326 NEVMREWAMAD-------NQSKNLPKADRQALNEHFQ----------SILQTLEEQVSGE 368
           N V  + +          N  K L + D     E F+          S L++   Q +  
Sbjct: 646 NWVALKPSQITGTVFTELNDEKVLQELDMSDFEEQFKTKSQGPSLDLSALKSKAAQKAPS 705

Query: 369 RQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERV--LLALRRYLRAEQKEQRH 426
           +  L+E +  + +A+   +     E    A++A   QA  +  L  L R+L  E   +R 
Sbjct: 706 KATLIEANRAKNLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEY--ERS 763

Query: 427 TLRHYQHVAAVDPEKAQQMRFQV-HTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELL 485
            +  ++       E +++ RF +  + +  + ER+  +L  L   P  AQ L PQ+  ++
Sbjct: 764 LITRFEREQRPMEELSEEDRFMLCFSRIPRLPERMT-TLTFLGNFPDTAQLLMPQLNAII 822


>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
          Length = 1460

 Score = 39.7 bits (91), Expect = 0.009
 Identities = 50/203 (24%), Positives = 87/203 (42%), Gaps = 30/203 (14%)

Query: 311 LRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGER- 369
           L+  ++ EE RMR+       W  A  QS    +AD   +    ++ LQ L E++  ++ 
Sbjct: 651 LQKAIEEEEARMREEESQRLSWLRAQVQSST--QADEDQIRAEQEASLQKLREELESQQK 708

Query: 370 --QRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHT 427
             +  +E    +++  + ++  A+ +   AAL A     E+ L  LR  L  E+KE   T
Sbjct: 709 AERASLEQKNRQMLEQLKEEIEASEKSEQAALNA---AKEKALQQLREQLEGERKEAVAT 765

Query: 428 L-----------------RHYQHVAAVD---PEKAQQMRFQVHTHLQVIEERVNQ-SLGL 466
           L                 +H + V+++     E  Q+   Q+   L  +E RV+Q S  +
Sbjct: 766 LEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHV 825

Query: 467 LDQNPHLAQELRPQIQELLHSEH 489
                 L+  LR + QE +  EH
Sbjct: 826 AGYEHELSSLLREKRQE-VEGEH 847



 Score = 38.9 bits (89), Expect = 0.015
 Identities = 39/161 (24%), Positives = 66/161 (40%), Gaps = 12/161 (7%)

Query: 264 EEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMR 323
           EEEE  +    S  L+ +     +    D   I       + +    L ++   E   + 
Sbjct: 656 EEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLE 715

Query: 324 QINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIAL 383
           Q N  M E    + ++    K+++ ALN   +  LQ L EQ+ GER+  V T        
Sbjct: 716 QKNRQMLEQLKEEIEASE--KSEQAALNAAKEKALQQLREQLEGERKEAVAT-------- 765

Query: 384 INDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQ 424
           +  +  A LE   ++L+A     E V    ++   A+QKE+
Sbjct: 766 LEKEHSAELERLCSSLEA--KHREVVSSLQKKIQEAQQKEE 804



 Score = 29.6 bits (65), Expect = 9.1
 Identities = 38/158 (24%), Positives = 64/158 (40%), Gaps = 23/158 (14%)

Query: 352 EH-FQSILQTLEEQVSGERQR----LVETHATRVIALINDQ-------RRAALEGFLAAL 399
           EH   S+L+   ++V GE +R    + E H  +V+A   +Q       +RA L G L   
Sbjct: 829 EHELSSLLREKRQEVEGEHERRLDKMKEEHQ-QVMAKAREQYEAEERKQRAELLGHLTG- 886

Query: 400 QADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEER 459
                + ER+  A  R L   ++EQ   L   +        K Q +   + T  + ++ R
Sbjct: 887 -----ELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKAR 941

Query: 460 VNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEA 497
               L LL+     A+  + Q+ ++     L   E  A
Sbjct: 942 ----LALLEVQEETARREKQQLLDVQRQVALKSEEATA 975


>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
           sapiens]
          Length = 1297

 Score = 39.3 bits (90), Expect = 0.011
 Identities = 53/203 (26%), Positives = 87/203 (42%), Gaps = 17/203 (8%)

Query: 300 MPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQ 359
           +PGE +    FLR ++  +ER     +E +R   +   Q +N  +  RQ L E  + I  
Sbjct: 344 LPGESTLRRDFLRLQLANKER-----SEALRRQQLEQQQREN-EEHKRQLLAERQKRI-- 395

Query: 360 TLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPP--QAERVLLALRRYL 417
             EEQ   E++R +E    R   L   Q R     +   ++ +    +AE     +RR L
Sbjct: 396 --EEQ--KEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQL 451

Query: 418 RAEQKEQRHTLRHYQHVAAVDPE-KAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQE 476
             EQ++     +   H  A+  E K +Q+  Q     + ++ ++ Q    L    H  QE
Sbjct: 452 EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQ--RQAERLQRQLKQERDYLVSLQHQRQE 509

Query: 477 LRPQIQELLHSEHLGPSELEAPA 499
            RP  ++ L+    G S  E PA
Sbjct: 510 QRPVEKKPLYHYKEGMSPSEKPA 532


>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
           sapiens]
          Length = 1305

 Score = 39.3 bits (90), Expect = 0.011
 Identities = 53/203 (26%), Positives = 87/203 (42%), Gaps = 17/203 (8%)

Query: 300 MPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQ 359
           +PGE +    FLR ++  +ER     +E +R   +   Q +N  +  RQ L E  + I  
Sbjct: 344 LPGESTLRRDFLRLQLANKER-----SEALRRQQLEQQQREN-EEHKRQLLAERQKRI-- 395

Query: 360 TLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPP--QAERVLLALRRYL 417
             EEQ   E++R +E    R   L   Q R     +   ++ +    +AE     +RR L
Sbjct: 396 --EEQ--KEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQL 451

Query: 418 RAEQKEQRHTLRHYQHVAAVDPE-KAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQE 476
             EQ++     +   H  A+  E K +Q+  Q     + ++ ++ Q    L    H  QE
Sbjct: 452 EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQ--RQAERLQRQLKQERDYLVSLQHQRQE 509

Query: 477 LRPQIQELLHSEHLGPSELEAPA 499
            RP  ++ L+    G S  E PA
Sbjct: 510 QRPVEKKPLYHYKEGMSPSEKPA 532


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.134    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,620,708
Number of Sequences: 37866
Number of extensions: 1852271
Number of successful extensions: 11596
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 64
Number of HSP's successfully gapped in prelim test: 315
Number of HSP's that attempted gapping in prelim test: 10476
Number of HSP's gapped (non-prelim): 1210
length of query: 650
length of database: 18,247,518
effective HSP length: 109
effective length of query: 541
effective length of database: 14,120,124
effective search space: 7638987084
effective search space used: 7638987084
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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