Search of human proteins with 4826786

Search of human proteins with 4826786

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4826786 Shaw-related voltage-gated potassium channel protein
1 isoform B [Homo sapiens]
         (511 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4826786 Shaw-related voltage-gated potassium channel protein ...  1059   0.0  
gi|163792201 Shaw-related voltage-gated potassium channel protei...  1040   0.0  
gi|24497460 Shaw-related voltage-gated potassium channel protein...   760   0.0  
gi|24497464 Shaw-related voltage-gated potassium channel protein...   752   0.0  
gi|88758576 Shaw-related voltage-gated potassium channel protein...   751   0.0  
gi|24497462 Shaw-related voltage-gated potassium channel protein...   751   0.0  
gi|21217561 Shaw-related voltage-gated potassium channel protein...   743   0.0  
gi|21217563 Shaw-related voltage-gated potassium channel protein...   743   0.0  
gi|24497458 Shaw-related voltage-gated potassium channel protein...   743   0.0  
gi|27436974 potassium voltage-gated channel, Shab-related subfam...   303   3e-82
gi|4826784 potassium voltage-gated channel, Shab-related subfami...   296   3e-80
gi|119395748 potassium voltage-gated channel subfamily A member ...   275   5e-74
gi|9789987 potassium voltage-gated channel, Shal-related subfami...   273   2e-73
gi|4504817 potassium voltage-gated channel, shaker-related subfa...   273   4e-73
gi|27436981 potassium voltage-gated channel, Shal-related subfam...   267   2e-71
gi|88758565 potassium voltage-gated channel, shaker-related subf...   265   6e-71
gi|25952092 potassium voltage-gated channel, shaker-related subf...   263   2e-70
gi|5031819 potassium voltage-gated channel, shaker-related subfa...   263   4e-70
gi|4826782 potassium voltage-gated channel, shaker-related subfa...   261   1e-69
gi|4504821 potassium voltage-gated channel, shaker-related subfa...   259   4e-69
gi|27436984 potassium voltage-gated channel, Shal-related subfam...   259   5e-69
gi|27436986 potassium voltage-gated channel, Shal-related subfam...   259   5e-69
gi|25952087 potassium voltage-gated channel, shaker-related subf...   257   2e-68
gi|25952108 potassium voltage-gated channel delayed-rectifier pr...   245   6e-65
gi|20070166 potassium voltage-gated channel, subfamily F, member...   245   6e-65
gi|13492973 potassium voltage-gated channel delayed-rectifier pr...   237   2e-62
gi|27436988 potassium voltage-gated channel, subfamily G, member...   233   2e-61
gi|6912444 potassium voltage-gated channel, subfamily G, member ...   225   6e-59
gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]    224   1e-58
gi|45383011 potassium voltage-gated channel, delayed-rectifier, ...   224   1e-58

>gi|4826786 Shaw-related voltage-gated potassium channel protein 1
           isoform B [Homo sapiens]
          Length = 511

 Score = 1059 bits (2738), Expect = 0.0
 Identities = 511/511 (100%), Positives = 511/511 (100%)

Query: 1   MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRH 60
           MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRH
Sbjct: 1   MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRH 60

Query: 61  PGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALD 120
           PGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALD
Sbjct: 61  PGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALD 120

Query: 121 SFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALF 180
           SFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALF
Sbjct: 121 SFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALF 180

Query: 181 EDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAE 240
           EDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAE
Sbjct: 181 EDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAE 240

Query: 241 TEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSS 300
           TEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSS
Sbjct: 241 TEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSS 300

Query: 301 KAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA 360
           KAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA
Sbjct: 301 KAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA 360

Query: 361 TMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALC 420
           TMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALC
Sbjct: 361 TMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALC 420

Query: 421 ALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPH 480
           ALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPH
Sbjct: 421 ALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPH 480

Query: 481 HSTQSDTCPLAQEEILEINRAGRKPLRGMSI 511
           HSTQSDTCPLAQEEILEINRAGRKPLRGMSI
Sbjct: 481 HSTQSDTCPLAQEEILEINRAGRKPLRGMSI 511


>gi|163792201 Shaw-related voltage-gated potassium channel protein 1
           isoform A [Homo sapiens]
          Length = 585

 Score = 1040 bits (2690), Expect = 0.0
 Identities = 502/504 (99%), Positives = 502/504 (99%)

Query: 1   MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRH 60
           MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRH
Sbjct: 1   MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRH 60

Query: 61  PGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALD 120
           PGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALD
Sbjct: 61  PGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALD 120

Query: 121 SFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALF 180
           SFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALF
Sbjct: 121 SFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALF 180

Query: 181 EDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAE 240
           EDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAE
Sbjct: 181 EDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAE 240

Query: 241 TEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSS 300
           TEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSS
Sbjct: 241 TEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSS 300

Query: 301 KAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA 360
           KAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA
Sbjct: 301 KAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA 360

Query: 361 TMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALC 420
           TMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALC
Sbjct: 361 TMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALC 420

Query: 421 ALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPH 480
           ALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPH
Sbjct: 421 ALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPH 480

Query: 481 HSTQSDTCPLAQEEILEINRAGRK 504
           HSTQSDTCPLAQEEILEINRA  K
Sbjct: 481 HSTQSDTCPLAQEEILEINRADSK 504


>gi|24497460 Shaw-related voltage-gated potassium channel protein 3
           [Homo sapiens]
          Length = 757

 Score =  760 bits (1962), Expect = 0.0
 Identities = 404/593 (68%), Positives = 433/593 (73%), Gaps = 100/593 (16%)

Query: 2   GQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHP 61
           G G +S +IVINVGG RH+TYRSTLRTLPGTRLA L EP+A + FDYDP ADEFFFDRHP
Sbjct: 82  GGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGADEFFFDRHP 141

Query: 62  GVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDS 121
           GVFA++LNYYRTGKLHCPADVCGPL+EEEL FWGIDETDVE CCWMTYRQHRDAEEALDS
Sbjct: 142 GVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDS 201

Query: 122 F------GGAPLDNSA--------DDADADGPGDSGDGEDELEMTKRLALSDSPDGR--- 164
           F      G A   N+A        D+A A G G  G G +     KRL   D+  G    
Sbjct: 202 FEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGE----LKRLCFQDAGGGAGGP 257

Query: 165 PGG-------FWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNP 217
           PGG       +WRRWQPR+WALFEDPYSSR ARYVAFASLFFIL+SITTFCLETHE F  
Sbjct: 258 PGGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIH 317

Query: 218 IVNKTEI----------ENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVIFC 267
           I NKT            EN+ N        E ETE FLTY+EGVCVVWFTFEFLMR+ FC
Sbjct: 318 ISNKTVTQASPIPGAPPENITNV-------EVETEPFLTYVEGVCVVWFTFEFLMRITFC 370

Query: 268 PNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRH 327
           P+KVEF+K+SLNIID VAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRH
Sbjct: 371 PDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRH 430

Query: 328 FVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNI 387
           FVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGA P+D   S HT+FKNI
Sbjct: 431 FVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNI 490

Query: 388 PIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAM 447
           PIGFWWAVVTMTTLGYGDMYP+TWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAM
Sbjct: 491 PIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAM 550

Query: 448 AKQKLPKKKKKHIPRPPQLGSPNYCK-----SVVNSPHHST------------------- 483
           AKQKLPKKK KHIPRPPQ GSPNYCK          PHH +                   
Sbjct: 551 AKQKLPKKKNKHIPRPPQPGSPNYCKPDPPPPPPPHPHHGSGGISPPPPITPPSMGVTVA 610

Query: 484 -------------------------------QSDTCPLAQEEILEINRAGRKP 505
                                            + CPLAQEE++EINRA  +P
Sbjct: 611 GAYPAGPHTHPGLLRGGAGGLGIMGLPPLPAPGEPCPLAQEEVIEINRADPRP 663


>gi|24497464 Shaw-related voltage-gated potassium channel protein 4
           isoform b [Homo sapiens]
          Length = 582

 Score =  752 bits (1942), Expect = 0.0
 Identities = 384/518 (74%), Positives = 421/518 (81%), Gaps = 23/518 (4%)

Query: 1   MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRAD------- 53
           M +G+ SE+I+INVGGTRH+TYRSTLRTLPGTRLAWLA+PD     + D           
Sbjct: 29  MAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSG 88

Query: 54  ----EFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTY 109
               EFFFDRHPGVFA++LNYYRTGKLHCPADVCGPL+EEEL FWGIDETDVEPCCWMTY
Sbjct: 89  GGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTY 148

Query: 110 RQHRDAEEALDSFGGAPLDNSADDADADGPGDSGD-GEDELEMT-KRLALSDSPDGRPGG 167
           RQHRDAEEALD F        + D    G G S + G+DE E+  +RL   +   G   G
Sbjct: 149 RQHRDAEEALDIF-------ESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAG 201

Query: 168 FW--RRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIE 225
               R WQPR+WALFEDPYSSR AR VAFASLFFILVSITTFCLETHE FN   N TEI 
Sbjct: 202 SGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEIL 261

Query: 226 NVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVA 285
            V N T V + RE ETE  LTYIEGVCV+WFT EFL+R++ CP+ ++F+KN LNIIDFVA
Sbjct: 262 RVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVA 321

Query: 286 ILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEF 345
           ILPFYLEVGLSGLSSKAA+DVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEF
Sbjct: 322 ILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEF 381

Query: 346 LLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGD 405
           LLLIIFLALGVLIFATMIYYAERIGA+P+DP  ++HT FKNIPIGFWWAVVTMTTLGYGD
Sbjct: 382 LLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGD 441

Query: 406 MYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQ 465
           MYP+TWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKK+KKH+PRP Q
Sbjct: 442 MYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQ 501

Query: 466 LGSPNYCKSVVNSPHHSTQSDTCPLAQEE-ILEINRAG 502
           L SP YCKS   SP  ST SDT P A+EE ++E  RAG
Sbjct: 502 LESPMYCKSEETSPRDSTCSDTSPPAREEGMIERKRAG 539


>gi|88758576 Shaw-related voltage-gated potassium channel protein 4
           isoform c [Homo sapiens]
          Length = 626

 Score =  751 bits (1939), Expect = 0.0
 Identities = 384/520 (73%), Positives = 421/520 (80%), Gaps = 23/520 (4%)

Query: 1   MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRAD------- 53
           M +G+ SE+I+INVGGTRH+TYRSTLRTLPGTRLAWLA+PD     + D           
Sbjct: 29  MAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSG 88

Query: 54  ----EFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTY 109
               EFFFDRHPGVFA++LNYYRTGKLHCPADVCGPL+EEEL FWGIDETDVEPCCWMTY
Sbjct: 89  GGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTY 148

Query: 110 RQHRDAEEALDSFGGAPLDNSADDADADGPGDSGD-GEDELEMT-KRLALSDSPDGRPGG 167
           RQHRDAEEALD F        + D    G G S + G+DE E+  +RL   +   G   G
Sbjct: 149 RQHRDAEEALDIF-------ESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAG 201

Query: 168 FW--RRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIE 225
               R WQPR+WALFEDPYSSR AR VAFASLFFILVSITTFCLETHE FN   N TEI 
Sbjct: 202 SGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEIL 261

Query: 226 NVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVA 285
            V N T V + RE ETE  LTYIEGVCV+WFT EFL+R++ CP+ ++F+KN LNIIDFVA
Sbjct: 262 RVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVA 321

Query: 286 ILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEF 345
           ILPFYLEVGLSGLSSKAA+DVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEF
Sbjct: 322 ILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEF 381

Query: 346 LLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGD 405
           LLLIIFLALGVLIFATMIYYAERIGA+P+DP  ++HT FKNIPIGFWWAVVTMTTLGYGD
Sbjct: 382 LLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGD 441

Query: 406 MYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQ 465
           MYP+TWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKK+KKH+PRP Q
Sbjct: 442 MYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQ 501

Query: 466 LGSPNYCKSVVNSPHHSTQSDTCPLAQEE-ILEINRAGRK 504
           L SP YCKS   SP  ST SDT P A+EE ++E  RA  K
Sbjct: 502 LESPMYCKSEETSPRDSTCSDTSPPAREEGMIERKRADSK 541


>gi|24497462 Shaw-related voltage-gated potassium channel protein 4
           isoform a [Homo sapiens]
          Length = 635

 Score =  751 bits (1939), Expect = 0.0
 Identities = 384/520 (73%), Positives = 421/520 (80%), Gaps = 23/520 (4%)

Query: 1   MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRAD------- 53
           M +G+ SE+I+INVGGTRH+TYRSTLRTLPGTRLAWLA+PD     + D           
Sbjct: 29  MAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSG 88

Query: 54  ----EFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTY 109
               EFFFDRHPGVFA++LNYYRTGKLHCPADVCGPL+EEEL FWGIDETDVEPCCWMTY
Sbjct: 89  GGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTY 148

Query: 110 RQHRDAEEALDSFGGAPLDNSADDADADGPGDSGD-GEDELEMT-KRLALSDSPDGRPGG 167
           RQHRDAEEALD F        + D    G G S + G+DE E+  +RL   +   G   G
Sbjct: 149 RQHRDAEEALDIF-------ESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAG 201

Query: 168 FW--RRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIE 225
               R WQPR+WALFEDPYSSR AR VAFASLFFILVSITTFCLETHE FN   N TEI 
Sbjct: 202 SGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEIL 261

Query: 226 NVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVA 285
            V N T V + RE ETE  LTYIEGVCV+WFT EFL+R++ CP+ ++F+KN LNIIDFVA
Sbjct: 262 RVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVA 321

Query: 286 ILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEF 345
           ILPFYLEVGLSGLSSKAA+DVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEF
Sbjct: 322 ILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEF 381

Query: 346 LLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGD 405
           LLLIIFLALGVLIFATMIYYAERIGA+P+DP  ++HT FKNIPIGFWWAVVTMTTLGYGD
Sbjct: 382 LLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGD 441

Query: 406 MYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQ 465
           MYP+TWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKK+KKH+PRP Q
Sbjct: 442 MYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQ 501

Query: 466 LGSPNYCKSVVNSPHHSTQSDTCPLAQEE-ILEINRAGRK 504
           L SP YCKS   SP  ST SDT P A+EE ++E  RA  K
Sbjct: 502 LESPMYCKSEETSPRDSTCSDTSPPAREEGMIERKRADSK 541


>gi|21217561 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2a [Homo sapiens]
          Length = 613

 Score =  743 bits (1918), Expect = 0.0
 Identities = 389/553 (70%), Positives = 424/553 (76%), Gaps = 67/553 (12%)

Query: 1   MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSH--------------- 45
           MG+ + +ER+++NVGGTRH+TYRSTL+TLPGTRLA LA  +                   
Sbjct: 1   MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60

Query: 46  FDYDPRAD--------------------------------EFFFDRHPGVFAHILNYYRT 73
               PRA                                 EFFFDRHPGVFA++LNYYRT
Sbjct: 61  LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120

Query: 74  GKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADD 133
           GKLHCPADVCGPL+EEELAFWGIDETDVEPCCWMTYRQHRDAEEALD F         + 
Sbjct: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIF---------ET 171

Query: 134 ADADGPGDSGDGEDELEMTKRLALSDS-----PDGRPGGFWRRWQPRIWALFEDPYSSRY 188
            D  G GD GD ED     KRL + D+     PDG+ G  WRR QPR+WALFEDPYSSR 
Sbjct: 172 PDLIG-GDPGDDEDLA--AKRLGIEDAAGLGGPDGKSGR-WRRLQPRMWALFEDPYSSRA 227

Query: 189 ARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYI 248
           AR++AFASLFFILVSITTFCLETHE FN + NKTE   V NGT V    E ET+  LTY+
Sbjct: 228 ARFIAFASLFFILVSITTFCLETHEAFNIVKNKTE--PVINGTSVVLQYEIETDPALTYV 285

Query: 249 EGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG 308
           EGVCVVWFTFEFL+R++F PNK+EFIKN LNIIDFVAILPFYLEVGLSGLSSKAAKDVLG
Sbjct: 286 EGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG 345

Query: 309 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER 368
           FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER
Sbjct: 346 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER 405

Query: 369 IGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI 428
           +GAQPNDPSASEHT FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI
Sbjct: 406 VGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI 465

Query: 429 AMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTC 488
           AMPVPVIVNNFGMYYSLAMAKQKLP+K+KKHIP  PQ  SP +CK+ +N   +STQSDTC
Sbjct: 466 AMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTC 525

Query: 489 PLAQEEILEINRA 501
                 +LE NR+
Sbjct: 526 LGKDNRLLEHNRS 538


>gi|21217563 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2b [Homo sapiens]
          Length = 638

 Score =  743 bits (1918), Expect = 0.0
 Identities = 389/553 (70%), Positives = 424/553 (76%), Gaps = 67/553 (12%)

Query: 1   MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSH--------------- 45
           MG+ + +ER+++NVGGTRH+TYRSTL+TLPGTRLA LA  +                   
Sbjct: 1   MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60

Query: 46  FDYDPRAD--------------------------------EFFFDRHPGVFAHILNYYRT 73
               PRA                                 EFFFDRHPGVFA++LNYYRT
Sbjct: 61  LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120

Query: 74  GKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADD 133
           GKLHCPADVCGPL+EEELAFWGIDETDVEPCCWMTYRQHRDAEEALD F         + 
Sbjct: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIF---------ET 171

Query: 134 ADADGPGDSGDGEDELEMTKRLALSDS-----PDGRPGGFWRRWQPRIWALFEDPYSSRY 188
            D  G GD GD ED     KRL + D+     PDG+ G  WRR QPR+WALFEDPYSSR 
Sbjct: 172 PDLIG-GDPGDDEDLA--AKRLGIEDAAGLGGPDGKSGR-WRRLQPRMWALFEDPYSSRA 227

Query: 189 ARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYI 248
           AR++AFASLFFILVSITTFCLETHE FN + NKTE   V NGT V    E ET+  LTY+
Sbjct: 228 ARFIAFASLFFILVSITTFCLETHEAFNIVKNKTE--PVINGTSVVLQYEIETDPALTYV 285

Query: 249 EGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG 308
           EGVCVVWFTFEFL+R++F PNK+EFIKN LNIIDFVAILPFYLEVGLSGLSSKAAKDVLG
Sbjct: 286 EGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG 345

Query: 309 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER 368
           FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER
Sbjct: 346 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER 405

Query: 369 IGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI 428
           +GAQPNDPSASEHT FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI
Sbjct: 406 VGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI 465

Query: 429 AMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTC 488
           AMPVPVIVNNFGMYYSLAMAKQKLP+K+KKHIP  PQ  SP +CK+ +N   +STQSDTC
Sbjct: 466 AMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTC 525

Query: 489 PLAQEEILEINRA 501
                 +LE NR+
Sbjct: 526 LGKDNRLLEHNRS 538


>gi|24497458 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2c [Homo sapiens]
          Length = 558

 Score =  743 bits (1918), Expect = 0.0
 Identities = 389/553 (70%), Positives = 424/553 (76%), Gaps = 67/553 (12%)

Query: 1   MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSH--------------- 45
           MG+ + +ER+++NVGGTRH+TYRSTL+TLPGTRLA LA  +                   
Sbjct: 1   MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPP 60

Query: 46  FDYDPRAD--------------------------------EFFFDRHPGVFAHILNYYRT 73
               PRA                                 EFFFDRHPGVFA++LNYYRT
Sbjct: 61  LSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT 120

Query: 74  GKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADD 133
           GKLHCPADVCGPL+EEELAFWGIDETDVEPCCWMTYRQHRDAEEALD F         + 
Sbjct: 121 GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIF---------ET 171

Query: 134 ADADGPGDSGDGEDELEMTKRLALSDS-----PDGRPGGFWRRWQPRIWALFEDPYSSRY 188
            D  G GD GD ED     KRL + D+     PDG+ G  WRR QPR+WALFEDPYSSR 
Sbjct: 172 PDLIG-GDPGDDEDLA--AKRLGIEDAAGLGGPDGKSGR-WRRLQPRMWALFEDPYSSRA 227

Query: 189 ARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYI 248
           AR++AFASLFFILVSITTFCLETHE FN + NKTE   V NGT V    E ET+  LTY+
Sbjct: 228 ARFIAFASLFFILVSITTFCLETHEAFNIVKNKTE--PVINGTSVVLQYEIETDPALTYV 285

Query: 249 EGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG 308
           EGVCVVWFTFEFL+R++F PNK+EFIKN LNIIDFVAILPFYLEVGLSGLSSKAAKDVLG
Sbjct: 286 EGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG 345

Query: 309 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER 368
           FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER
Sbjct: 346 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAER 405

Query: 369 IGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI 428
           +GAQPNDPSASEHT FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI
Sbjct: 406 VGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI 465

Query: 429 AMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTC 488
           AMPVPVIVNNFGMYYSLAMAKQKLP+K+KKHIP  PQ  SP +CK+ +N   +STQSDTC
Sbjct: 466 AMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTC 525

Query: 489 PLAQEEILEINRA 501
                 +LE NR+
Sbjct: 526 LGKDNRLLEHNRS 538


>gi|27436974 potassium voltage-gated channel, Shab-related
           subfamily, member 2 [Homo sapiens]
          Length = 911

 Score =  303 bits (775), Expect = 3e-82
 Identities = 174/466 (37%), Positives = 250/466 (53%), Gaps = 76/466 (16%)

Query: 7   SERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHF-----DYDPRADEFFFDRHP 61
           S R+ INVGG  H+    TL  LP TRL  L + + H        DY+   +E+FFDRHP
Sbjct: 34  SRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHP 93

Query: 62  GVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDA------ 115
           G F  ILN+YRTGKLH   ++C   + +EL +WGIDE  +E CC   Y Q ++       
Sbjct: 94  GAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELR 153

Query: 116 --EEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQ 173
              E +    G   DN+                              PD R         
Sbjct: 154 REAETMREREGEEFDNTC----------------------------CPDKRK-------- 177

Query: 174 PRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQV 233
            ++W L E P SS  A+ +A  S+ FI++S     L T           E++      Q+
Sbjct: 178 -KLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNT---------LPELQETDEFGQL 227

Query: 234 RYYREAETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEV 293
              R+      L ++E VC+ WFT E+L+R +  PNK +F K  LN+ID +AILP+Y+ +
Sbjct: 228 NDNRQ------LAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTI 281

Query: 294 GL--SGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIF 351
            L  S  S    ++V   +++ R +RILRI KL RH  GL+ LG TLR S NE  LLI+F
Sbjct: 282 FLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILF 341

Query: 352 LALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTW 411
           LA+G++IF++++++AE+           + T F +IP  FWWA +TMTT+GYGD+YP+T 
Sbjct: 342 LAMGIMIFSSLVFFAEK---------DEDATKFTSIPASFWWATITMTTVGYGDIYPKTL 392

Query: 412 SGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKK 457
            G +VG LC +AGVL IA+P+P+IVNNF  +Y     ++K  K+++
Sbjct: 393 LGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRRE 438


>gi|4826784 potassium voltage-gated channel, Shab-related subfamily,
           member 1 [Homo sapiens]
          Length = 858

 Score =  296 bits (758), Expect = 3e-80
 Identities = 170/458 (37%), Positives = 249/458 (54%), Gaps = 60/458 (13%)

Query: 7   SERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHF-----DYDPRADEFFFDRHP 61
           S R+ +NVGG  H+    TL  LP TRL  L + + H        DY    +E+FFDRHP
Sbjct: 30  SRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYFFDRHP 89

Query: 62  GVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDS 121
           G F  ILN+YRTG+LH   ++C   + +EL +WGIDE  +E CC   Y Q ++       
Sbjct: 90  GAFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNE--- 146

Query: 122 FGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFE 181
                L   A+    +  G+  D     E  K+L                     W L E
Sbjct: 147 ----ELKREAETL-REREGEEFDNTCCAEKRKKL---------------------WDLLE 180

Query: 182 DPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAET 241
            P SS  A+ +A  S+ FI++S     L T           E++++        + ++  
Sbjct: 181 KPNSSVAAKILAIISIMFIVLSTIALSLNT---------LPELQSLDE------FGQSTD 225

Query: 242 EAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGL--SGLS 299
              L ++E VC+ WFT E+L+R +  P K +F K  LN ID +AILP+Y+ + L  S  S
Sbjct: 226 NPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKS 285

Query: 300 SKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIF 359
               ++V   +++ R +RILRI KL RH  GL+ LG TLR S NE  LLI+FLA+G++IF
Sbjct: 286 VLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIF 345

Query: 360 ATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGAL 419
           ++++++AE+           + T FK+IP  FWWA +TMTT+GYGD+YP+T  G +VG L
Sbjct: 346 SSLVFFAEK---------DEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGL 396

Query: 420 CALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKK 457
           C +AGVL IA+P+P+IVNNF  +Y     ++K  K+++
Sbjct: 397 CCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRRE 434


>gi|119395748 potassium voltage-gated channel subfamily A member 1
           [Homo sapiens]
          Length = 495

 Score =  275 bits (704), Expect = 5e-74
 Identities = 167/442 (37%), Positives = 238/442 (53%), Gaps = 69/442 (15%)

Query: 8   ERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHI 67
           ER+VIN+ G R +T   TL   P T L     P     + +DP  +E+FFDR+   F  I
Sbjct: 37  ERVVINISGLRFETQLKTLAQFPNTLLG---NPKKRMRY-FDPLRNEYFFDRNRPSFDAI 92

Query: 68  LNYYRTG-KLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAP 126
           L YY++G +L  P +V   ++ EE+ F+ +                   EEA++ F    
Sbjct: 93  LYYYQSGGRLRRPVNVPLDMFSEEIKFYEL------------------GEEAMEKFRE-- 132

Query: 127 LDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSS 186
                         D G  ++E                     + +Q ++W LFE P SS
Sbjct: 133 --------------DEGFIKEEERPLPE---------------KEYQRQVWLLFEYPESS 163

Query: 187 RYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLT 246
             AR +A  S+  IL+SI  FCLET        + T   +  + T V Y     T+ F  
Sbjct: 164 GPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFI 223

Query: 247 YIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLS-----GLSSK 301
            +E +C++WF+FE ++R   CP+K +F KN +N ID VAI+P+++ +G       G    
Sbjct: 224 -VETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKG 282

Query: 302 AAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFAT 361
                L  LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI FL +GV++F++
Sbjct: 283 EQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSS 342

Query: 362 MIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCA 421
            +Y+AE   A+         +HF +IP  FWWAVV+MTT+GYGDMYP T  G +VG+LCA
Sbjct: 343 AVYFAEAEEAE---------SHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCA 393

Query: 422 LAGVLTIAMPVPVIVNNFGMYY 443
           +AGVLTIA+PVPVIV+NF  +Y
Sbjct: 394 IAGVLTIALPVPVIVSNFNYFY 415


>gi|9789987 potassium voltage-gated channel, Shal-related subfamily,
           member 2 [Homo sapiens]
          Length = 630

 Score =  273 bits (699), Expect = 2e-73
 Identities = 174/499 (34%), Positives = 261/499 (52%), Gaps = 76/499 (15%)

Query: 10  IVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILN 69
           IV+NV GTR QT++ TL   P T L       +   F Y P   ++FFDR P +F HILN
Sbjct: 43  IVLNVSGTRFQTWQDTLERYPDTLLG-----SSERDFFYHPETQQYFFDRDPDIFRHILN 97

Query: 70  YYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDN 129
           +YRTGKLH P   C   Y+EELAF+G+    +  CC+  Y+  R  E A         + 
Sbjct: 98  FYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRR-RENA---------ER 147

Query: 130 SADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYA 189
             DDAD D  G+S        MT R                    R+W  FE+P++S  A
Sbjct: 148 LQDDADTDTAGESALPT----MTAR-------------------QRVWRAFENPHTSTMA 184

Query: 190 RYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYRE---AETEAFLT 246
               + + FFI VS+    +ET               V  G+   + +E    E  A   
Sbjct: 185 LVFYYVTGFFIAVSVIANVVET---------------VPCGSSPGHIKELPCGERYAVAF 229

Query: 247 Y-IEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKD 305
           + ++  CV+ FT E+L+R+   P++  F+++ ++IID VAILP+Y+     GL     +D
Sbjct: 230 FCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYI-----GLVMTDNED 284

Query: 306 VLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYY 365
           V G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++IFAT+++Y
Sbjct: 285 VSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFY 344

Query: 366 AERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGV 425
           AE+          S  + F +IP  FW+ +VTMTTLGYGDM P+T +G + G++C+L+GV
Sbjct: 345 AEK---------GSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGV 395

Query: 426 LTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIP--RPPQLGSPNYCKSVVNSPHHST 483
           L IA+PVPVIV+NF   Y       K   +KK  +   R  + GS N   + + S  +  
Sbjct: 396 LVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAKSGSAN---AYMQSKRNGL 452

Query: 484 QSDTCPLAQEEILEINRAG 502
            S+    +++E   ++++G
Sbjct: 453 LSNQLQSSEDEQAFVSKSG 471


>gi|4504817 potassium voltage-gated channel, shaker-related
           subfamily, member 4 [Homo sapiens]
          Length = 653

 Score =  273 bits (697), Expect = 4e-73
 Identities = 176/462 (38%), Positives = 252/462 (54%), Gaps = 90/462 (19%)

Query: 5   DESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVF 64
           D  ER+VINV G R +T   TL   P T L    +P+  + + +DP  +E+FFDR+   F
Sbjct: 173 DCCERVVINVSGLRFETQMKTLAQFPETLLG---DPEKRTQY-FDPLRNEYFFDRNRPSF 228

Query: 65  AHILNYYRTG-KLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFG 123
             IL YY++G +L  P +V   ++ EE+ F+ +                   EEAL  F 
Sbjct: 229 DAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQL------------------GEEALLKF- 269

Query: 124 GAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDP 183
                        +  G   + ED        AL ++           ++ +IW LFE P
Sbjct: 270 ------------REDEGFVREEEDR-------ALPEN----------EFKKQIWLLFEYP 300

Query: 184 YSSRYARYVAFASLFFILVSITTFCLETHERFNP---------------IVNKTEIENVR 228
            SS  AR +A  S+  IL+SI  FCLET   F                 ++N T   ++ 
Sbjct: 301 ESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLE 360

Query: 229 NGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILP 288
           N     +      + F   +E VC+VWF+FEF++R   CP++  F KN +NIID V+ILP
Sbjct: 361 NSGHTIF-----NDPFFI-VETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILP 414

Query: 289 FYLEVGLS-----GLSSKAAKDVLGF--LRVVRFVRILRIFKLTRHFVGLRVLGHTLRAS 341
           +++ +G       G  +   +  + F  LR++R VR+ RIFKL+RH  GL++LGHTLRAS
Sbjct: 415 YFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRAS 474

Query: 342 TNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTL 401
             E  LLI FL +GV++F++ +Y+AE      ++P+    THF++IP  FWWAVVTMTT+
Sbjct: 475 MRELGLLIFFLFIGVILFSSAVYFAEA-----DEPT----THFQSIPDAFWWAVVTMTTV 525

Query: 402 GYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 443
           GYGDM P T  G +VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 526 GYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 567


>gi|27436981 potassium voltage-gated channel, Shal-related
           subfamily, member 1 [Homo sapiens]
          Length = 647

 Score =  267 bits (682), Expect = 2e-71
 Identities = 163/460 (35%), Positives = 246/460 (53%), Gaps = 62/460 (13%)

Query: 3   QGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPG 62
           +GDE   +V+NV G R +T+++TL   P T L       +   F YD  + E+FFDR P 
Sbjct: 37  RGDEV--LVVNVSGRRFETWKNTLDRYPDTLLG-----SSEKEFFYDADSGEYFFDRDPD 89

Query: 63  VFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSF 122
           +F H+LN+YRTG+LHCP   C   ++EELAF+G+    V  CC   YR  R  E A    
Sbjct: 90  MFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRD-RKKENA---- 144

Query: 123 GGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFED 182
                +  A+D +A+  GD                       P G   R   R+W  FE+
Sbjct: 145 -----ERLAEDEEAEQAGDG-------------------PALPAGSSLR--QRLWRAFEN 178

Query: 183 PYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETE 242
           P++S  A    + + FFI VS+    +ET              + R  ++ +   E   +
Sbjct: 179 PHTSTAALVFYYVTGFFIAVSVIANVVETIPCRG---------SARRSSREQPCGERFPQ 229

Query: 243 AFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKA 302
           AF   ++  CV+ FT E+L+R+   P++  F+++ +++ID VAILP+Y+     GL    
Sbjct: 230 AFFC-MDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYI-----GLLVPK 283

Query: 303 AKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATM 362
             DV G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++IFAT+
Sbjct: 284 NDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATV 343

Query: 363 IYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCAL 422
           ++YAE+          +  T+F +IP  FW+ +VTMTTLGYGDM P T +G + G++C+L
Sbjct: 344 MFYAEK---------GTNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSL 394

Query: 423 AGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPR 462
           +GVL IA+PVPVIV+NF   Y       K   ++K  + R
Sbjct: 395 SGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQQKVRLAR 434


>gi|88758565 potassium voltage-gated channel, shaker-related
           subfamily, member 3 [Homo sapiens]
          Length = 575

 Score =  265 bits (678), Expect = 6e-71
 Identities = 167/448 (37%), Positives = 239/448 (53%), Gaps = 76/448 (16%)

Query: 8   ERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHI 67
           ER+VIN+ G R +T   TL   P T L    +P     + +DP  +E+FFDR+   F  I
Sbjct: 104 ERVVINISGLRFETQLKTLCQFPETLLG---DPKRRMRY-FDPLRNEYFFDRNRPSFDAI 159

Query: 68  LNYYRTG-KLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAP 126
           L YY++G ++  P +V   ++ EE+ F+ +                   EEA++ F    
Sbjct: 160 LYYYQSGGRIRRPVNVPIDIFSEEIRFYQL------------------GEEAMEKFRE-- 199

Query: 127 LDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSS 186
                         D G   +E     R               R +Q ++W LFE P SS
Sbjct: 200 --------------DEGFLREEERPLPR---------------RDFQRQVWLLFEYPESS 230

Query: 187 RYARYVAFASLFFILVSITTFCLETHERFNP------IVNKTEIENVRNGTQVRYYREAE 240
             AR +A  S+  IL+SI  FCLET   F          ++   E   N T       + 
Sbjct: 231 GPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASS 290

Query: 241 TEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLS---- 296
                  +E +C++WF+FE L+R   CP+K  F +N +N+ID VAI+P+++ +G      
Sbjct: 291 FSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAER 350

Query: 297 -GLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALG 355
            G   +A    L  LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI FL +G
Sbjct: 351 QGNGQQAMS--LAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIG 408

Query: 356 VLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGML 415
           V++F++ +Y+AE      +DP++     F +IP  FWWAVVTMTT+GYGDM+P T  G +
Sbjct: 409 VILFSSAVYFAEA-----DDPTSG----FSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKI 459

Query: 416 VGALCALAGVLTIAMPVPVIVNNFGMYY 443
           VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 460 VGSLCAIAGVLTIALPVPVIVSNFNYFY 487


>gi|25952092 potassium voltage-gated channel, shaker-related
           subfamily, member 7 [Homo sapiens]
          Length = 456

 Score =  263 bits (673), Expect = 2e-70
 Identities = 175/454 (38%), Positives = 239/454 (52%), Gaps = 83/454 (18%)

Query: 8   ERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHI 67
           ER+V+NV G R +T   TL   P T L    +P     F YD    E+FFDRH   F  +
Sbjct: 13  ERLVLNVAGLRFETRARTLGRFPDTLLG---DPARRGRF-YDDARREYFFDRHRPSFDAV 68

Query: 68  LNYYRTG-KLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAP 126
           L YY++G +L  PA V   ++ EE+AF+G+                          G A 
Sbjct: 69  LYYYQSGGRLRRPAHVPLDVFLEEVAFYGL--------------------------GAAA 102

Query: 127 LDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSS 186
           L    +D     P                   + P  R     R +  ++W LFE P SS
Sbjct: 103 LARLREDEGCPVP------------------PERPLPR-----RAFARQLWLLFEFPESS 139

Query: 187 RYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVR---------NGTQV---R 234
           + AR +A  S+  ILVSI  FCLET   F    + T +             NG+      
Sbjct: 140 QAARVLAVVSVLVILVSIVVFCLETLPDFRDDRDGTGLAAAAAAGPFPAPLNGSSQMPGN 199

Query: 235 YYREAETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVG 294
             R    + F   +E +C+ WF+FE L+R++ CP+K  F KN +N+IDFVAILP+++ +G
Sbjct: 200 PPRLPFNDPFFV-VETLCICWFSFELLVRLLVCPSKAIFFKNVMNLIDFVAILPYFVALG 258

Query: 295 LS-----GLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLI 349
                  G+  +A    L  LRV+R VR+ RIFKL+RH  GL++LG TLRAS  E  LLI
Sbjct: 259 TELARQRGVGQQAMS--LAILRVIRLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLI 316

Query: 350 IFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQ 409
            FL +GV++F++ +Y+AE              +HF +IP  FWWAVVTMTT+GYGDM P 
Sbjct: 317 FFLFIGVVLFSSAVYFAEVDRVD---------SHFTSIPESFWWAVVTMTTVGYGDMAPV 367

Query: 410 TWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 443
           T  G +VG+LCA+AGVLTI++PVPVIV+NF  +Y
Sbjct: 368 TVGGKIVGSLCAIAGVLTISLPVPVIVSNFSYFY 401


>gi|5031819 potassium voltage-gated channel, shaker-related
           subfamily, member 10 [Homo sapiens]
          Length = 511

 Score =  263 bits (671), Expect = 4e-70
 Identities = 169/464 (36%), Positives = 251/464 (54%), Gaps = 80/464 (17%)

Query: 7   SERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAH 66
           ++R++IN+ G R +T   TL   P T L    + +    F +D   +E+FFDR+   F  
Sbjct: 85  NQRVIINIAGLRFETQLRTLSQFPETLLG---DREKRMQF-FDSMRNEYFFDRNRPSFDG 140

Query: 67  ILNYYRTG-KLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGA 125
           IL YY++G K+  PA+V   ++ +E++F+ +                    EA+D F   
Sbjct: 141 ILYYYQSGGKIRRPANVPIDIFADEISFYEL------------------GSEAMDQFR-- 180

Query: 126 PLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYS 185
                               EDE  +     L  + D            + W LFE P S
Sbjct: 181 --------------------EDEGFIKDPETLLPTND---------IHRQFWLLFEYPES 211

Query: 186 SRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVR----NGTQVRYYREAET 241
           S  AR VA  S+  +++SIT FCLET   F       E++ VR    N ++    +   T
Sbjct: 212 SSAARAVAVVSVLVVVISITIFCLETLPEFR---EDRELKVVRDPNLNMSKTVLSQTMFT 268

Query: 242 EAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYL----EVGLSG 297
           + F   +E  C+VWFTFE ++R + CP+K +F +N +NIID ++I+P++     E+    
Sbjct: 269 DPFFM-VESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQET 327

Query: 298 LSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVL 357
             S      L  LR++R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI FL +GV+
Sbjct: 328 EPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVI 387

Query: 358 IFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVG 417
           +F++ +Y+AE      ++P +    HF +IP GFWWAVVTMTT+GYGDM P T  G +VG
Sbjct: 388 LFSSAVYFAE-----VDEPES----HFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVG 438

Query: 418 ALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIP 461
            LCA+AGVLTIA+PVPVIV+NF  +Y      ++   ++K++IP
Sbjct: 439 TLCAIAGVLTIALPVPVIVSNFNYFY-----HRETENEEKQNIP 477


>gi|4826782 potassium voltage-gated channel, shaker-related
           subfamily, member 2 [Homo sapiens]
          Length = 499

 Score =  261 bits (666), Expect = 1e-69
 Identities = 163/449 (36%), Positives = 241/449 (53%), Gaps = 77/449 (17%)

Query: 8   ERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHI 67
           ER+VIN+ G R +T   TL   P T L    +P     + +DP  +E+FFDR+   F  I
Sbjct: 33  ERVVINISGLRFETQLKTLAQFPETLLG---DPKKRMRY-FDPLRNEYFFDRNRPSFDAI 88

Query: 68  LNYYRTG-KLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAP 126
           L YY++G +L  P +V   ++ EE+ F+ +                   EEA++ F    
Sbjct: 89  LYYYQSGGRLRRPVNVPLDIFSEEIRFYEL------------------GEEAMEMFRE-- 128

Query: 127 LDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSS 186
                         D G  ++E                       +Q ++W LFE P SS
Sbjct: 129 --------------DEGYIKEEERPLPE---------------NEFQRQVWLLFEYPESS 159

Query: 187 RYARYVAFASLFFILVSITTFCLETHERF---NPIVNKTEIE-NVRNGTQVRYYREAETE 242
             AR +A  S+  IL+SI +FCLET   F   N  ++ + +  +  + + + Y +     
Sbjct: 160 GPARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFT 219

Query: 243 AFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKA 302
                +E +C++WF+FEFL+R   CP+K  F  N +NIID VAI+P+++ +G     ++ 
Sbjct: 220 DPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTE--LAEK 277

Query: 303 AKDV--------LGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLAL 354
            +D         L  LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI FL +
Sbjct: 278 PEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFI 337

Query: 355 GVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGM 414
           GV++F++ +Y+AE         +    + F +IP  FWWAVV+MTT+GYGDM P T  G 
Sbjct: 338 GVILFSSAVYFAE---------ADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGK 388

Query: 415 LVGALCALAGVLTIAMPVPVIVNNFGMYY 443
           +VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 389 IVGSLCAIAGVLTIALPVPVIVSNFNYFY 417


>gi|4504821 potassium voltage-gated channel, shaker-related
           subfamily, member 6 [Homo sapiens]
          Length = 529

 Score =  259 bits (662), Expect = 4e-69
 Identities = 175/487 (35%), Positives = 249/487 (51%), Gaps = 111/487 (22%)

Query: 7   SERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAH 66
           SER+VIN+ G R +T   TL   P T L    +P     F +DP  +E+FFDR+   F  
Sbjct: 40  SERLVINISGLRFETQLRTLSLFPDTLLG---DPGRRVRF-FDPLRNEYFFDRNRPSFDA 95

Query: 67  ILNYYRTG-KLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGA 125
           IL YY++G +L  P +V   ++ EE+ F+ +                   +EAL +F   
Sbjct: 96  ILYYYQSGGRLRRPVNVPLDIFLEEIRFYQL------------------GDEALAAF--- 134

Query: 126 PLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYS 185
                    + +G    G GEDE  +  +                 +Q ++W LFE P S
Sbjct: 135 --------REDEGCLPEG-GEDEKPLPSQ----------------PFQRQVWLLFEYPES 169

Query: 186 SRYARYVAFASLFFILVSITTFCLETHERF--------NPIVNKTEIENVRNGTQVRYYR 237
           S  AR +A  S+  IL+SI  FCLET  +F        N  V++  +  V  G+Q     
Sbjct: 170 SGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSR--VSPVSRGSQEEEED 227

Query: 238 EAETEAF----------------------------LTYIEGVCVVWFTFEFLMRVIFCPN 269
           E ++  F                               +E +C+VWFTFE L+R   CP+
Sbjct: 228 EDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPS 287

Query: 270 KVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLG-------------FLRVVRFV 316
           K  F +N +NIID VAI P+++ +G   +  +  +   G              LRV+R V
Sbjct: 288 KPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLV 347

Query: 317 RILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDP 376
           R+ RIFKL+RH  GL++LG TL+AS  E  LLI FL +GV++F++ +Y+AE         
Sbjct: 348 RVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAE--------- 398

Query: 377 SASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIV 436
           +  + + F +IP  FWWAVVTMTT+GYGDMYP T  G +VG+LCA+AGVLTIA+PVPVIV
Sbjct: 399 ADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIV 458

Query: 437 NNFGMYY 443
           +NF  +Y
Sbjct: 459 SNFNYFY 465


>gi|27436984 potassium voltage-gated channel, Shal-related
           subfamily, member 3 isoform 1 [Homo sapiens]
          Length = 655

 Score =  259 bits (661), Expect = 5e-69
 Identities = 160/459 (34%), Positives = 240/459 (52%), Gaps = 69/459 (15%)

Query: 6   ESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFA 65
           + E IV+NV G R QT+R+TL   P T L           F ++    E+FFDR P VF 
Sbjct: 38  QDELIVLNVSGRRFQTWRTTLERYPDTLLG-----STEKEFFFNEDTKEYFFDRDPEVFR 92

Query: 66  HILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTY--RQHRDAEEALDSFG 123
            +LN+YRTGKLH P   C   Y++ELAF+GI    +  CC+  Y  R+  +AE  +D   
Sbjct: 93  CVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMD--- 149

Query: 124 GAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDP 183
               DN +++     P  S                             ++  +W  FE+P
Sbjct: 150 ----DNDSENNQESMPSLS-----------------------------FRQTMWRAFENP 176

Query: 184 YSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEA 243
           ++S  A    + + FFI VS+ T  +ET                  G++     E  + A
Sbjct: 177 HTSTLALVFYYVTGFFIAVSVITNVVETVPC-----------GTVPGSKELPCGERYSVA 225

Query: 244 FLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAA 303
           F   ++  CV+ FT E+L+R+   P++  FI++ ++IID VAI+P+Y+     GL     
Sbjct: 226 FFC-LDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYI-----GLVMTNN 279

Query: 304 KDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMI 363
           +DV G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++IFAT++
Sbjct: 280 EDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVM 339

Query: 364 YYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALA 423
           +YAE+          S  + F +IP  FW+ +VTMTTLGYGDM P+T +G + G++C+L+
Sbjct: 340 FYAEK---------GSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLS 390

Query: 424 GVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPR 462
           GVL IA+PVPVIV+NF   Y       K   +KK  + R
Sbjct: 391 GVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLAR 429


>gi|27436986 potassium voltage-gated channel, Shal-related
           subfamily, member 3 isoform 2 [Homo sapiens]
          Length = 636

 Score =  259 bits (661), Expect = 5e-69
 Identities = 160/459 (34%), Positives = 240/459 (52%), Gaps = 69/459 (15%)

Query: 6   ESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFA 65
           + E IV+NV G R QT+R+TL   P T L           F ++    E+FFDR P VF 
Sbjct: 38  QDELIVLNVSGRRFQTWRTTLERYPDTLLG-----STEKEFFFNEDTKEYFFDRDPEVFR 92

Query: 66  HILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTY--RQHRDAEEALDSFG 123
            +LN+YRTGKLH P   C   Y++ELAF+GI    +  CC+  Y  R+  +AE  +D   
Sbjct: 93  CVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMD--- 149

Query: 124 GAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDP 183
               DN +++     P  S                             ++  +W  FE+P
Sbjct: 150 ----DNDSENNQESMPSLS-----------------------------FRQTMWRAFENP 176

Query: 184 YSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEA 243
           ++S  A    + + FFI VS+ T  +ET                  G++     E  + A
Sbjct: 177 HTSTLALVFYYVTGFFIAVSVITNVVETVPC-----------GTVPGSKELPCGERYSVA 225

Query: 244 FLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAA 303
           F   ++  CV+ FT E+L+R+   P++  FI++ ++IID VAI+P+Y+     GL     
Sbjct: 226 FFC-LDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYI-----GLVMTNN 279

Query: 304 KDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMI 363
           +DV G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++IFAT++
Sbjct: 280 EDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVM 339

Query: 364 YYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALA 423
           +YAE+          S  + F +IP  FW+ +VTMTTLGYGDM P+T +G + G++C+L+
Sbjct: 340 FYAEK---------GSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLS 390

Query: 424 GVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPR 462
           GVL IA+PVPVIV+NF   Y       K   +KK  + R
Sbjct: 391 GVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLAR 429


>gi|25952087 potassium voltage-gated channel, shaker-related
           subfamily, member 5 [Homo sapiens]
          Length = 613

 Score =  257 bits (657), Expect = 2e-68
 Identities = 172/472 (36%), Positives = 244/472 (51%), Gaps = 104/472 (22%)

Query: 8   ERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHI 67
           +R+ IN+ G R +T   TL   P T L    +P     + +DP  +E+FFDR+   F  I
Sbjct: 120 QRVHINISGLRFETQLGTLAQFPNTLLG---DPAKRLRY-FDPLRNEYFFDRNRPSFDGI 175

Query: 68  LNYYRTG-KLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAP 126
           L YY++G +L  P +V   ++ +E+ F+ +                   +EA++ F    
Sbjct: 176 LYYYQSGGRLRRPVNVSLDVFADEIRFYQL------------------GDEAMERFRE-- 215

Query: 127 LDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSS 186
                         D G  ++E +   R                 +Q ++W +FE P SS
Sbjct: 216 --------------DEGFIKEEEKPLPR---------------NEFQRQVWLIFEYPESS 246

Query: 187 RYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVR---------------NGT 231
             AR +A  S+  IL+SI TFCLET   F     + E E +R               NG+
Sbjct: 247 GSARAIAIVSVLVILISIITFCLETLPEF-----RDERELLRHPPAPHQPPAPAPGANGS 301

Query: 232 QVRYYREAETEAFLT---------YIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIID 282
            V       T A L           +E  CV+WFTFE L+R   CP+K  F +N +NIID
Sbjct: 302 GVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIID 361

Query: 283 FVAILPFYLEVGLS-----------GLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGL 331
            VAI P+++ +G             G + + A   L  LRV+R VR+ RIFKL+RH  GL
Sbjct: 362 VVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMS-LAILRVIRLVRVFRIFKLSRHSKGL 420

Query: 332 RVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGF 391
           ++LG TL+AS  E  LLI FL +GV++F++ +Y+AE         + ++ THF +IP  F
Sbjct: 421 QILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAE---------ADNQGTHFSSIPDAF 471

Query: 392 WWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 443
           WWAVVTMTT+GYGDM P T  G +VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 472 WWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 523


>gi|25952108 potassium voltage-gated channel delayed-rectifier
           protein S3 [Homo sapiens]
          Length = 491

 Score =  245 bits (626), Expect = 6e-65
 Identities = 147/449 (32%), Positives = 230/449 (51%), Gaps = 55/449 (12%)

Query: 4   GDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHF-----DYDPRADEFFFD 58
           G + E + +NVGG +    +STL   P TRL  L    +         DY     E++FD
Sbjct: 11  GQDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFD 70

Query: 59  RHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEA 118
           R+P +F ++LN+Y TGKLH   ++C   + +E+ +WGI+E  ++ CC   Y++ ++    
Sbjct: 71  RNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNRYQERKEENHE 130

Query: 119 LDSFGGAPLDNSADDADADGP-GDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIW 177
            D       D  + D   D    +S   E ELE    L               + + +IW
Sbjct: 131 KD------WDQKSHDVSTDSSFEESSLFEKELEKFDTLRFG------------QLRKKIW 172

Query: 178 ALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYR 237
              E+P     A+ +A +SL  +L SI   C+ +   F     + +              
Sbjct: 173 IRMENPAYCLSAKLIAISSLSVVLASIVAMCVHSMSEFQNEDGEVD-------------- 218

Query: 238 EAETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFY--LEVGL 295
               +  L  +E  C+ WFT E  +R+   P + +F KN LNIIDFV+I+PFY  L V  
Sbjct: 219 ----DPVLEGVEIACIAWFTGELAVRLAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDT 274

Query: 296 SGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALG 355
               S+  +++   ++++R +RI RI KL RH VGLR LG TLR S +E  LL++FL++G
Sbjct: 275 KEEESEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVG 334

Query: 356 VLIFATMIYYAERIGAQPNDPSASEHTH-FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGM 414
           + IF+ +IY  E+           +HT    +IPI +WWA ++MTT+GYGD +P T +G 
Sbjct: 335 ISIFSVLIYSVEK----------DDHTSSLTSIPICWWWATISMTTVGYGDTHPVTLAGK 384

Query: 415 LVGALCALAGVLTIAMPVPVIVNNFGMYY 443
           L+ + C + G+L +A+P+ +I N F  YY
Sbjct: 385 LIASTCIICGILVVALPITIIFNKFSKYY 413


>gi|20070166 potassium voltage-gated channel, subfamily F, member 1
           [Homo sapiens]
          Length = 494

 Score =  245 bits (626), Expect = 6e-65
 Identities = 156/459 (33%), Positives = 226/459 (49%), Gaps = 67/459 (14%)

Query: 10  IVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHF-------DYDPRADEFFFDRHPG 62
           IV+NVGG R   Y   L   P TRLA L    A  +        DYDP   EF+FDR P 
Sbjct: 25  IVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDDYDPGKREFYFDRDPD 84

Query: 63  VFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSF 122
            F  ++  Y  G++H    +C   ++ E+ FW +D   ++ CC     + R+  E     
Sbjct: 85  AFKCVIEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREELE----- 139

Query: 123 GGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFED 182
                                    E+    +L L D       G WRR Q  +W   E 
Sbjct: 140 -------------------------EIARRVQLILDDLGVDAAEGRWRRCQKCVWKFLEK 174

Query: 183 PYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETE 242
           P SS  AR VA  S   ILVS    C+ T       V   E   V + T           
Sbjct: 175 PESSCPARVVAVLSFLLILVSSVVMCMGTIPELQ--VLDAEGNRVEHPT----------- 221

Query: 243 AFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKA 302
             L  +E  C+ WFT E+L+R+   PNK+ F  + +NI+D +AILPFY+ + L+ L ++ 
Sbjct: 222 --LENVETACIGWFTLEYLLRLFSSPNKLHFALSFMNIVDVLAILPFYVSLTLTHLGARM 279

Query: 303 AK--DVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA 360
            +  +V   ++ +R +RI RIFKL RH  GL+ L + L+ S  E  LL+++LA+G+ +F+
Sbjct: 280 MELTNVQQAVQALRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFS 339

Query: 361 TMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALC 420
            + Y  E+         +   T FK+IP  FWWA++TMTT+GYGD+YP+T  G L  A+ 
Sbjct: 340 ALGYTMEQ---------SHPETLFKSIPQSFWWAIITMTTVGYGDIYPKTTLGKLNAAIS 390

Query: 421 ALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKH 459
            L GV+ IA+P+  I+NNF  YY+    KQ++ +   KH
Sbjct: 391 FLCGVIAIALPIHPIINNFVRYYN----KQRVLETAAKH 425


>gi|13492973 potassium voltage-gated channel delayed-rectifier
           protein S1 [Homo sapiens]
          Length = 526

 Score =  237 bits (604), Expect = 2e-62
 Identities = 146/445 (32%), Positives = 217/445 (48%), Gaps = 39/445 (8%)

Query: 8   ERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHF-----DYDPRADEFFFDRHPG 62
           E + +NVGG R Q     L   PGTRL  L    +         DYD  A EF+FDRHPG
Sbjct: 50  EALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPG 109

Query: 63  VFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSF 122
            F  +L++YRTG LH   ++C   + +E  +WG+ E  +  CC   Y + R  +      
Sbjct: 110 FFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQP----- 164

Query: 123 GGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFED 182
                   A D D+D P       DE+   +R  L+     R G    R + R+W   E+
Sbjct: 165 -------HAWDEDSDTPSSVDPCPDEISDVQR-ELARYGAARCG----RLRRRLWLTMEN 212

Query: 183 PYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETE 242
           P  S  ++  +  S+  +L SI   C+ +   +        +  V  G      R+   +
Sbjct: 213 PGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRD---D 269

Query: 243 AFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLE----VGLSGL 298
             L  +E  C+ WF+FE   R++  P+   F  + LN+ID V++LPFYL     V L   
Sbjct: 270 PVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQ 329

Query: 299 SSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLI 358
             K    +   ++V R +RI R+ KL RH  GLR LG TL+ S  E  +L+++LA+GV +
Sbjct: 330 GGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSV 389

Query: 359 FATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGA 418
           F+ + Y AE+           E   F  IP  +WW  V+MTT+GYGD+ P T +G L  +
Sbjct: 390 FSGVAYTAEK----------EEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAAS 439

Query: 419 LCALAGVLTIAMPVPVIVNNFGMYY 443
            C L G+L +A+P+ +I N F  +Y
Sbjct: 440 GCILGGILVVALPITIIFNKFSHFY 464


>gi|27436988 potassium voltage-gated channel, subfamily G, member 1
           [Homo sapiens]
          Length = 513

 Score =  233 bits (595), Expect = 2e-61
 Identities = 152/457 (33%), Positives = 228/457 (49%), Gaps = 67/457 (14%)

Query: 5   DESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFD--------YDPRADEFF 56
           D   RI+INVGG ++    +TL   P TRL  L    A ++FD        YD   +EFF
Sbjct: 60  DRRRRIIINVGGIKYSLPWTTLDEFPLTRLGQLK---ACTNFDDILNVCDDYDVTCNEFF 116

Query: 57  FDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAE 116
           FDR+PG F  IL + R GKL    ++C   ++EEL +WGI E  ++ CC   Y Q     
Sbjct: 117 FDRNPGAFGTILTFLRAGKLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQ----- 171

Query: 117 EALDSFGGAPLDNSADDA-DADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPR 175
             ++ F         DDA D++G    G  E E              GR G   RR +  
Sbjct: 172 -KIEEFAEMVEREEEDDALDSEGRDSEGPAEGE--------------GRLGRCMRRLRDM 216

Query: 176 IWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRY 235
           +    E P+S    +  A  S+ F+ V+     + T            + ++R   +  +
Sbjct: 217 V----ERPHSGLPGKVFACLSVLFVTVTAVNLSVST------------LPSLREEEEQGH 260

Query: 236 YREAETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGL 295
             +     F+  +E VCV WF+ EFL+R+I  P+K  F+++ L +ID VAILP+Y+ + +
Sbjct: 261 CSQMCHNVFI--VESVCVGWFSLEFLLRLIQAPSKFAFLRSPLTLIDLVAILPYYITLLV 318

Query: 296 SGLSSKAAKDVLG---------FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFL 346
            G ++   K   G          LRV+R +RIL + +L RH +GL+ LG T R  T EF 
Sbjct: 319 DGAAAGRRKPGAGNSYLDKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTREFG 378

Query: 347 LLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDM 406
           LL++FL + + +FA ++Y  E           ++   F +IP  +WWAV+TMTT+GYGDM
Sbjct: 379 LLLLFLCVAIALFAPLLYVIEN--------EMADSPEFTSIPACYWWAVITMTTVGYGDM 430

Query: 407 YPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 443
            P++  G +V     L+G+L +A PV  I + F   Y
Sbjct: 431 VPRSTPGQVVALSSILSGILLMAFPVTSIFHTFSRSY 467


>gi|6912444 potassium voltage-gated channel, subfamily G, member 2
           [Homo sapiens]
          Length = 466

 Score =  225 bits (574), Expect = 6e-59
 Identities = 151/460 (32%), Positives = 225/460 (48%), Gaps = 60/460 (13%)

Query: 2   GQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHF-----DYDPRADEFF 56
           G G  +  ++INVGG R +   + L   P  RL  L     H        DYD   DEFF
Sbjct: 11  GGGTRARHVIINVGGCRVRLAWAALARCPLARLERLRACRGHDDLLRVCDDYDVSRDEFF 70

Query: 57  FDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAE 116
           FDR P  F  I+   R GKL      C   + +ELA+WGIDE  +E CC    R  R  E
Sbjct: 71  FDRSPCAFRAIVALLRAGKLRLLRGPCALAFRDELAYWGIDEARLERCCLRRLR--RREE 128

Query: 117 EALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRI 176
           EA ++  G P +  A  + A   G                        P G  +R + R+
Sbjct: 129 EAAEARAG-PTERGAQGSPARALG------------------------PRGRLQRGRRRL 163

Query: 177 WALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYY 236
             + ++P+S    +  A  S+ F+ V+    CL T         + E E      + R  
Sbjct: 164 RDVVDNPHSGLAGKLFACVSVSFVAVTAVGLCLSTMPDI-----RAEEERGECSPKCRS- 217

Query: 237 REAETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLS 296
                   L  +E VCV WF+FEFL+R +   +K  F++  LNIID +A+LPFY+ + L 
Sbjct: 218 --------LFVLETVCVAWFSFEFLLRSLQAESKCAFLRAPLNIIDILALLPFYVSLLLG 269

Query: 297 GLSSKAAKDVLG----FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFL 352
             +      +L      LR++R +R+L + +L RH +GLR LG T+R    EF LL++FL
Sbjct: 270 LAAGPGGTKLLERAGLVLRLLRALRVLYVMRLARHSLGLRSLGLTMRRCAREFGLLLLFL 329

Query: 353 ALGVLIFATMIYYAER-IGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTW 411
            + + +FA +++ AER +GA+ +         F ++P  +WWAV++MTT+GYGDM P++ 
Sbjct: 330 CVAMALFAPLVHLAERELGARRD---------FSSVPASYWWAVISMTTVGYGDMVPRSL 380

Query: 412 SGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQK 451
            G +V     L+G+L +A PV  I + F   YS    +Q+
Sbjct: 381 PGQVVALSSILSGILLMAFPVTSIFHTFSRSYSELKEQQQ 420


>gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]
          Length = 500

 Score =  224 bits (571), Expect = 1e-58
 Identities = 141/465 (30%), Positives = 232/465 (49%), Gaps = 77/465 (16%)

Query: 12  INVGGTRHQTYRSTLRTLPGTRLAWLA-------EPDAHSHF--------DYDPRADEFF 56
           +NVGG+R    +  L   P TRL  LA        P A +          D +P  +E+F
Sbjct: 43  VNVGGSRFVLSQQALSCFPHTRLGKLAVVVASYRRPGALAAVPSPLELCDDANPVDNEYF 102

Query: 57  FDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAE 116
           FDR    F ++L+YYRTG+LH    +C   + +E+ +WGIDE  ++ CC   Y + ++  
Sbjct: 103 FDRSSQAFRYVLHYYRTGRLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKELS 162

Query: 117 EALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRI 176
           E LD                    D+ D E + E  +  +    P  R          ++
Sbjct: 163 ETLDF-----------------KKDTEDQESQHESEQDFSQGPCPTVR---------QKL 196

Query: 177 WALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYY 236
           W + E P SS  AR     S+ F++VSI    L + E     ++  +++           
Sbjct: 197 WNILEKPGSSTAARIFGVISIIFVVVSIINMALMSAE-----LSWLDLQ----------- 240

Query: 237 REAETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLS 296
                   L  +E VC+ WFT EF++R +   ++  F++   NIID +AILPFY+ + + 
Sbjct: 241 -------LLEILEYVCISWFTGEFVLRFLCVRDRCRFLRKVPNIIDLLAILPFYITLLVE 293

Query: 297 GLS----SKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFL 352
            LS    ++  ++V   ++V+R +R LR+ KL RH  GLR LG T+     E  LL++FL
Sbjct: 294 SLSGSQTTQELENVGRIVQVLRLLRALRMLKLGRHSTGLRSLGMTITQCYEEVGLLLLFL 353

Query: 353 ALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWS 412
           ++G+ IF+T+ Y+AE+         +   T F ++P  +WWA  +MTT+GYGD+ P T +
Sbjct: 354 SVGISIFSTVEYFAEQ---------SIPDTTFTSVPCAWWWATTSMTTVGYGDIRPDTTT 404

Query: 413 GMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKK 457
           G +V  +C L+G+L +A+P+ +I + F   Y     K+   ++++
Sbjct: 405 GKIVAFMCILSGILVLALPIAIINDRFSACYFTLKLKEAAVRQRE 449


>gi|45383011 potassium voltage-gated channel, delayed-rectifier,
           subfamily S, member 2 [Homo sapiens]
          Length = 477

 Score =  224 bits (571), Expect = 1e-58
 Identities = 144/446 (32%), Positives = 224/446 (50%), Gaps = 51/446 (11%)

Query: 6   ESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHF-----DYDPRADEFFFDRH 60
           E   I INVGG + +    TL   P TRL  L    +         DYD    EF+FDR+
Sbjct: 15  EDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRN 74

Query: 61  PGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALD 120
           P +F ++L++Y TGKLH  A++C   + +E+ +WGI+E  ++ CC  +Y   +   E   
Sbjct: 75  PELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQ-- 132

Query: 121 SFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALF 180
                  +   + +D +    S D     E+      +   DG+P G +RR   ++W   
Sbjct: 133 -------EKWDEQSDQESTTSSFD-----EILAFYNDASKFDGQPLGNFRR---QLWLAL 177

Query: 181 EDPYSSRYARYVAFASLFFILVSITTFCLETHERFN-PIVNKTEIENVRNGTQVRYYREA 239
           ++P  S  +R  +  S+  ++ SI T CL +   F  P       E+ R           
Sbjct: 178 DNPGYSVLSRVFSILSILVVMGSIITMCLNSLPDFQIPDSQGNPGEDPR----------- 226

Query: 240 ETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFY--LEVGLSG 297
                   +E   + WFTFE + R    P+ ++F KN+LN+ID ++I+PFY  L V L  
Sbjct: 227 -----FEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVV 281

Query: 298 LSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVL 357
            S+    ++    +V+R +RI RI KL RH  GLR LG TL+ S  E  LL+++L++G+ 
Sbjct: 282 ESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGIS 341

Query: 358 IFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVG 417
           IF+ + Y  E+           E+     IP  +WWA V+MTT+GYGD+ P T +G L  
Sbjct: 342 IFSVVAYTIEK----------EENEGLATIPACWWWATVSMTTVGYGDVVPGTTAGKLTA 391

Query: 418 ALCALAGVLTIAMPVPVIVNNFGMYY 443
           + C LAG+L + +P+ +I N F  +Y
Sbjct: 392 SACILAGILVVVLPITLIFNKFSHFY 417


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.140    0.445 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,780,220
Number of Sequences: 37866
Number of extensions: 1003988
Number of successful extensions: 3136
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 156
Number of HSP's successfully gapped in prelim test: 54
Number of HSP's that attempted gapping in prelim test: 2423
Number of HSP's gapped (non-prelim): 532
length of query: 511
length of database: 18,247,518
effective HSP length: 107
effective length of query: 404
effective length of database: 14,195,856
effective search space: 5735125824
effective search space used: 5735125824
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.