Search of human proteins with 4826782

Search of human proteins with 4826782

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4826782 potassium voltage-gated channel, shaker-related
subfamily, member 2 [Homo sapiens]
         (499 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4826782 potassium voltage-gated channel, shaker-related subfa...  1000   0.0  
gi|119395748 potassium voltage-gated channel subfamily A member ...   776   0.0  
gi|88758565 potassium voltage-gated channel, shaker-related subf...   712   0.0  
gi|4504817 potassium voltage-gated channel, shaker-related subfa...   652   0.0  
gi|4504821 potassium voltage-gated channel, shaker-related subfa...   623   e-178
gi|25952087 potassium voltage-gated channel, shaker-related subf...   622   e-178
gi|5031819 potassium voltage-gated channel, shaker-related subfa...   580   e-165
gi|25952092 potassium voltage-gated channel, shaker-related subf...   561   e-160
gi|4826784 potassium voltage-gated channel, Shab-related subfami...   278   1e-74
gi|27436981 potassium voltage-gated channel, Shal-related subfam...   275   7e-74
gi|27436974 potassium voltage-gated channel, Shab-related subfam...   272   6e-73
gi|27436984 potassium voltage-gated channel, Shal-related subfam...   266   4e-71
gi|27436986 potassium voltage-gated channel, Shal-related subfam...   266   4e-71
gi|163792201 Shaw-related voltage-gated potassium channel protei...   265   7e-71
gi|9789987 potassium voltage-gated channel, Shal-related subfami...   264   1e-70
gi|4826786 Shaw-related voltage-gated potassium channel protein ...   261   1e-69
gi|88758576 Shaw-related voltage-gated potassium channel protein...   258   9e-69
gi|24497462 Shaw-related voltage-gated potassium channel protein...   258   9e-69
gi|24497464 Shaw-related voltage-gated potassium channel protein...   258   9e-69
gi|21217561 Shaw-related voltage-gated potassium channel protein...   246   3e-65
gi|21217563 Shaw-related voltage-gated potassium channel protein...   246   3e-65
gi|24497458 Shaw-related voltage-gated potassium channel protein...   246   3e-65
gi|45383011 potassium voltage-gated channel, delayed-rectifier, ...   233   3e-61
gi|20070166 potassium voltage-gated channel, subfamily F, member...   230   2e-60
gi|13492973 potassium voltage-gated channel delayed-rectifier pr...   229   3e-60
gi|24497460 Shaw-related voltage-gated potassium channel protein...   229   6e-60
gi|25952108 potassium voltage-gated channel delayed-rectifier pr...   222   7e-58
gi|27436988 potassium voltage-gated channel, subfamily G, member...   218   1e-56
gi|27436996 potassium voltage-gated channel, subfamily G, member...   213   2e-55
gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]    211   1e-54

>gi|4826782 potassium voltage-gated channel, shaker-related
           subfamily, member 2 [Homo sapiens]
          Length = 499

 Score = 1000 bits (2586), Expect = 0.0
 Identities = 499/499 (100%), Positives = 499/499 (100%)

Query: 1   MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLG 60
           MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLG
Sbjct: 1   MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLG 60

Query: 61  DPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE 120
           DPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE
Sbjct: 61  DPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE 120

Query: 121 EAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSF 180
           EAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSF
Sbjct: 121 EAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSF 180

Query: 181 CLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVR 240
           CLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVR
Sbjct: 181 CLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVR 240

Query: 241 FFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVR 300
           FFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVR
Sbjct: 241 FFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVR 300

Query: 301 VFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPS 360
           VFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPS
Sbjct: 301 VFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPS 360

Query: 361 IPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE 420
           IPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE
Sbjct: 361 IPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE 420

Query: 421 TEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTA 480
           TEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTA
Sbjct: 421 TEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTA 480

Query: 481 NCTLANTNYVNITKMLTDV 499
           NCTLANTNYVNITKMLTDV
Sbjct: 481 NCTLANTNYVNITKMLTDV 499


>gi|119395748 potassium voltage-gated channel subfamily A member 1
           [Homo sapiens]
          Length = 495

 Score =  776 bits (2005), Expect = 0.0
 Identities = 404/503 (80%), Positives = 440/503 (87%), Gaps = 12/503 (2%)

Query: 1   MTVATGDPADEAAALPGHPQD-TYDPEADH---ECCERVVINISGLRFETQLKTLAQFPE 56
           MTV +G+  DEA+A PGHPQD +Y  +ADH   ECCERVVINISGLRFETQLKTLAQFP 
Sbjct: 1   MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPN 60

Query: 57  TLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFY 116
           TLLG+PKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLD+FSEEI+FY
Sbjct: 61  TLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFY 120

Query: 117 ELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILIS 176
           ELGEEAME FREDEG+IKEEERPLPE E+QRQVWLLFEYPESSGPAR+IAIVSVMVILIS
Sbjct: 121 ELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILIS 180

Query: 177 IVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFE 236
           IV FCLETLP  +D+ +D  G   T H   N+T+ Y  S  FTDPFFIVETLCIIWFSFE
Sbjct: 181 IVIFCLETLPELKDD-KDFTG---TVHRIDNTTVIY-NSNIFTDPFFIVETLCIIWFSFE 235

Query: 237 FLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVI 296
            +VRFFACPSK  FF NIMN IDIVAIIPYFITLGTE+AE+ E  Q+G+QA SLAILRVI
Sbjct: 236 LVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQ-EGNQKGEQATSLAILRVI 294

Query: 297 RLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERES 356
           RLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEA+E ES
Sbjct: 295 RLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAES 354

Query: 357 QFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYF 416
            F SIPDAFWWAVVSMTTVGYGDM P TIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYF
Sbjct: 355 HFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYF 414

Query: 417 YHRETEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREEN 476
           YHRETEGEEQAQ L V+S P + S  DL + RS+ST+SKS+YMEI+E +NNS   +R+ N
Sbjct: 415 YHRETEGEEQAQLLHVSS-PNLASDSDLSR-RSSSTMSKSEYMEIEEDMNNSIAHYRQVN 472

Query: 477 LKTANCTLANTNYVNITKMLTDV 499
           ++TANCT AN N VN +K+LTDV
Sbjct: 473 IRTANCTTANQNCVNKSKLLTDV 495


>gi|88758565 potassium voltage-gated channel, shaker-related
           subfamily, member 3 [Homo sapiens]
          Length = 575

 Score =  712 bits (1837), Expect = 0.0
 Identities = 384/514 (74%), Positives = 422/514 (82%), Gaps = 21/514 (4%)

Query: 3   VATGDPADEAAALPGHPQDTYDP-------EADHECC-ERVVINISGLRFETQLKTLAQF 54
           VA G  A       G   D Y+P         + +CC ERVVINISGLRFETQLKTL QF
Sbjct: 66  VADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQF 125

Query: 55  PETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIR 114
           PETLLGDPK+RMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGR+RRPVNVP+DIFSEEIR
Sbjct: 126 PETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIR 185

Query: 115 FYELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVIL 174
           FY+LGEEAME FREDEG+++EEERPLP  +FQRQVWLLFEYPESSGPAR IAIVSV+VIL
Sbjct: 186 FYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVIL 245

Query: 175 ISIVSFCLETLPIFRDENE-DMHGSGVTFHTYSNSTIGYQQ-STSFTDPFFIVETLCIIW 232
           ISIV FCLETLP FRDE +     S  +F    NST G +  ++SF+DPFF+VETLCIIW
Sbjct: 246 ISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIW 305

Query: 233 FSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAI 292
           FSFE LVRFFACPSKA F  NIMN+IDIVAIIPYFITLGTELAE+  +   GQQAMSLAI
Sbjct: 306 FSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGN---GQQAMSLAI 362

Query: 293 LRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAD 352
           LRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAD
Sbjct: 363 LRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAD 422

Query: 353 ERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSN 412
           +  S F SIPDAFWWAVV+MTTVGYGDM P TIGGKIVGSLCAIAGVLTIALPVPVIVSN
Sbjct: 423 DPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSN 482

Query: 413 FNYFYHRETEGEEQAQYLQVTSCPKIPSS-PDLKKSRSASTISKSDYMEIQE-GVNNS-- 468
           FNYFYHRETEGEEQ+QY+ V SC  + SS  +L+K+RS ST+SKS+YM I+E G+N+S  
Sbjct: 483 FNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAF 542

Query: 469 -NEDFREENLKTANCTLAN--TNYVNITKMLTDV 499
               F+  N  TA CT  N   + VNI K+ TDV
Sbjct: 543 PQTPFKTGN-STATCTTNNNPNSCVNIKKIFTDV 575


>gi|4504817 potassium voltage-gated channel, shaker-related
           subfamily, member 4 [Homo sapiens]
          Length = 653

 Score =  652 bits (1683), Expect = 0.0
 Identities = 342/477 (71%), Positives = 388/477 (81%), Gaps = 16/477 (3%)

Query: 7   DPADEAAALPGHPQDT----YDPEADHECCERVVINISGLRFETQLKTLAQFPETLLGDP 62
           D  DE +     PQD     Y      +CCERVVIN+SGLRFETQ+KTLAQFPETLLGDP
Sbjct: 146 DHGDECSYTDLLPQDEGGGGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPETLLGDP 205

Query: 63  KKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEA 122
           +KR +YFDPLRNEYFFDRNRPSFDAILYYYQSGGRL+RPVNVP DIF+EE++FY+LGEEA
Sbjct: 206 EKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEA 265

Query: 123 MEMFREDEGYIKEEE-RPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFC 181
           +  FREDEG+++EEE R LPENEF++Q+WLLFEYPESS PAR IAIVSV+VILISIV FC
Sbjct: 266 LLKFREDEGFVREEEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFC 325

Query: 182 LETLPIFRDENE-----DMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFE 236
           LETLP FRD+ +        G G   +  S   +     T F DPFFIVET+CI+WFSFE
Sbjct: 326 LETLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFE 385

Query: 237 FLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQ-QGQQAMSLAILRV 295
           F+VR FACPS+A FF NIMNIIDIV+I+PYFITLGT+LA++      Q QQAMS AILR+
Sbjct: 386 FVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRI 445

Query: 296 IRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERE 355
           IRLVRVFRIFKLSRHSKGLQILG TL+ASMRELGLLIFFLFIGVILFSSAVYFAEADE  
Sbjct: 446 IRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPT 505

Query: 356 SQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNY 415
           + F SIPDAFWWAVV+MTTVGYGDM P T+GGKIVGSLCAIAGVLTIALPVPVIVSNFNY
Sbjct: 506 THFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNY 565

Query: 416 FYHRETEGEEQAQYLQ-VTSCPKIPSSPDLKKSRSASTIS---KSDYMEIQEGVNNS 468
           FYHRETE EEQ Q  Q   SCP +PS+  LKK RS+++ S   KS+Y+E++EGV  S
Sbjct: 566 FYHRETENEEQTQLTQNAVSCPYLPSNL-LKKFRSSTSSSLGDKSEYLEMEEGVKES 621


>gi|4504821 potassium voltage-gated channel, shaker-related
           subfamily, member 6 [Homo sapiens]
          Length = 529

 Score =  623 bits (1606), Expect = e-178
 Identities = 347/528 (65%), Positives = 390/528 (73%), Gaps = 63/528 (11%)

Query: 17  GHPQDTYD-PEADHE--CC--ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDP 71
           G  QD  D PEA     CC  ER+VINISGLRFETQL+TL+ FP+TLLGDP +R+R+FDP
Sbjct: 20  GEQQDAGDFPEAGGGGGCCSSERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDP 79

Query: 72  LRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEG 131
           LRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIF EEIRFY+LG+EA+  FREDEG
Sbjct: 80  LRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGDEALAAFREDEG 139

Query: 132 YIKE---EERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIF 188
            + E   +E+PLP   FQRQVWLLFEYPESSGPAR IAIVSV+VILISIV FCLETLP F
Sbjct: 140 CLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQF 199

Query: 189 R---------------------DENEDMHGSGVTFH---------TYSNSTIGYQQSTSF 218
           R                      E E+      TFH         T  +S++     + F
Sbjct: 200 RVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFF 259

Query: 219 TDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKP 278
           TDPFF+VETLCI+WF+FE LVRF ACPSK  FF NIMNIID+VAI PYFITLGTEL ++ 
Sbjct: 260 TDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQ 319

Query: 279 ED-------AQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLL 331
           E         Q GQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILG+TL+ASMRELGLL
Sbjct: 320 EQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLL 379

Query: 332 IFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVG 391
           IFFLFIGVILFSSAVYFAEAD+ +S FPSIPDAFWWAVV+MTTVGYGDM P T+GGKIVG
Sbjct: 380 IFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVG 439

Query: 392 SLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQVTSCPKIPSSPDLKKSRSAS 451
           SLCAIAGVLTIALPVPVIVSNFNYFYHRETE EEQ QY  VT C +   +PDL+ + +  
Sbjct: 440 SLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTHVT-CGQ--PAPDLRATDNG- 495

Query: 452 TISKSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV 499
            + K D+ E       +N + R   L T +   A        +MLT+V
Sbjct: 496 -LGKPDFPE-------ANRERRPSYLPTPHRAYAE------KRMLTEV 529


>gi|25952087 potassium voltage-gated channel, shaker-related
           subfamily, member 5 [Homo sapiens]
          Length = 613

 Score =  622 bits (1605), Expect = e-178
 Identities = 321/415 (77%), Positives = 348/415 (83%), Gaps = 21/415 (5%)

Query: 33  ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY 92
           +RV INISGLRFETQL TLAQFP TLLGDP KR+RYFDPLRNEYFFDRNRPSFD ILYYY
Sbjct: 120 QRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYY 179

Query: 93  QSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLL 152
           QSGGRLRRPVNV LD+F++EIRFY+LG+EAME FREDEG+IKEEE+PLP NEFQRQVWL+
Sbjct: 180 QSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLI 239

Query: 153 FEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENE----------------DMH 196
           FEYPESSG AR IAIVSV+VILISI++FCLETLP FRDE E                  +
Sbjct: 240 FEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGAN 299

Query: 197 GSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMN 256
           GSGV     S  T+      +  DPFFIVET C+IWF+FE LVRFFACPSKAGF  NIMN
Sbjct: 300 GSGV-MAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMN 358

Query: 257 IIDIVAIIPYFITLGTELAEKPE----DAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSK 312
           IID+VAI PYFITLGTELAE+        Q GQQAMSLAILRVIRLVRVFRIFKLSRHSK
Sbjct: 359 IIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSK 418

Query: 313 GLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSM 372
           GLQILG+TL+ASMRELGLLIFFLFIGVILFSSAVYFAEAD + + F SIPDAFWWAVV+M
Sbjct: 419 GLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTM 478

Query: 373 TTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQA 427
           TTVGYGDM P T+GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRET+ EE A
Sbjct: 479 TTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPA 533


>gi|5031819 potassium voltage-gated channel, shaker-related
           subfamily, member 10 [Homo sapiens]
          Length = 511

 Score =  580 bits (1495), Expect = e-165
 Identities = 295/414 (71%), Positives = 337/414 (81%), Gaps = 8/414 (1%)

Query: 15  LPGHPQDTYDPEAD--HECCERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPL 72
           LPG   D   PE    +E  +RV+INI+GLRFETQL+TL+QFPETLLGD +KRM++FD +
Sbjct: 66  LPGDYADPPGPEPVVLNEGNQRVIINIAGLRFETQLRTLSQFPETLLGDREKRMQFFDSM 125

Query: 73  RNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGY 132
           RNEYFFDRNRPSFD ILYYYQSGG++RRP NVP+DIF++EI FYELG EAM+ FREDEG+
Sbjct: 126 RNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDIFADEISFYELGSEAMDQFREDEGF 185

Query: 133 IKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDEN 192
           IK+ E  LP N+  RQ WLLFEYPESS  AR +A+VSV+V++ISI  FCLETLP FR++ 
Sbjct: 186 IKDPETLLPTNDIHRQFWLLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPEFREDR 245

Query: 193 EDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFT 252
           E      V      N +      T FTDPFF+VE+ CI+WF+FE ++RF  CPSK  FF 
Sbjct: 246 E----LKVVRDPNLNMSKTVLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFFR 301

Query: 253 NIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSK 312
           NIMNIIDI++IIPYF TL TEL ++ E +   QQ MSLAILR+IRLVRVFRIFKLSRHSK
Sbjct: 302 NIMNIIDIISIIPYFATLITELVQETEPS--AQQNMSLAILRIIRLVRVFRIFKLSRHSK 359

Query: 313 GLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSM 372
           GLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE DE ES F SIPD FWWAVV+M
Sbjct: 360 GLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTM 419

Query: 373 TTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQ 426
           TTVGYGDM PTT GGKIVG+LCAIAGVLTIALPVPVIVSNFNYFYHRETE EE+
Sbjct: 420 TTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEK 473


>gi|25952092 potassium voltage-gated channel, shaker-related
           subfamily, member 7 [Homo sapiens]
          Length = 456

 Score =  561 bits (1446), Expect = e-160
 Identities = 282/416 (67%), Positives = 327/416 (78%), Gaps = 16/416 (3%)

Query: 31  CCERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILY 90
           CCER+V+N++GLRFET+ +TL +FP+TLLGDP +R R++D  R EYFFDR+RPSFDA+LY
Sbjct: 11  CCERLVLNVAGLRFETRARTLGRFPDTLLGDPARRGRFYDDARREYFFDRHRPSFDAVLY 70

Query: 91  YYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPLPENEFQRQVW 150
           YYQSGGRLRRP +VPLD+F EE+ FY LG  A+   REDEG     ERPLP   F RQ+W
Sbjct: 71  YYQSGGRLRRPAHVPLDVFLEEVAFYGLGAAALARLREDEGCPVPPERPLPRRAFARQLW 130

Query: 151 LLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGVTFHTY----- 205
           LLFE+PESS  AR++A+VSV+VIL+SIV FCLETLP FRD+ +   G+G+          
Sbjct: 131 LLFEFPESSQAARVLAVVSVLVILVSIVVFCLETLPDFRDDRD---GTGLAAAAAAGPFP 187

Query: 206 -----SNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDI 260
                S+   G      F DPFF+VETLCI WFSFE LVR   CPSKA FF N+MN+ID 
Sbjct: 188 APLNGSSQMPGNPPRLPFNDPFFVVETLCICWFSFELLVRLLVCPSKAIFFKNVMNLIDF 247

Query: 261 VAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQT 320
           VAI+PYF+ LGTELA +      GQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQT
Sbjct: 248 VAILPYFVALGTELARQ---RGVGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQT 304

Query: 321 LKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDM 380
           L+ASMRELGLLIFFLFIGV+LFSSAVYFAE D  +S F SIP++FWWAVV+MTTVGYGDM
Sbjct: 305 LRASMRELGLLIFFLFIGVVLFSSAVYFAEVDRVDSHFTSIPESFWWAVVTMTTVGYGDM 364

Query: 381 VPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQVTSCP 436
            P T+GGKIVGSLCAIAGVLTI+LPVPVIVSNF+YFYHRETEGEE   +  V   P
Sbjct: 365 APVTVGGKIVGSLCAIAGVLTISLPVPVIVSNFSYFYHRETEGEEAGMFSHVDMQP 420


>gi|4826784 potassium voltage-gated channel, Shab-related subfamily,
           member 1 [Homo sapiens]
          Length = 858

 Score =  278 bits (710), Expect = 1e-74
 Identities = 178/500 (35%), Positives = 271/500 (54%), Gaps = 58/500 (11%)

Query: 13  AALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPL 72
           ++LP  P +    +A   C  RV +N+ GL  E   +TL + P T LG  +    +   L
Sbjct: 14  SSLPPEPMEIVRSKA---CSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLL 70

Query: 73  R---------NEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEI---------- 113
                     NEYFFDR+  +F +IL +Y++G RL     +    FS+E+          
Sbjct: 71  EVCDDYSLDDNEYFFDRHPGAFTSILNFYRTG-RLHMMEEMCALSFSQELDYWGIDEIYL 129

Query: 114 ------RFYELGEEAMEMFREDEGYIKEEERPLPEN----EFQRQVWLLFEYPESSGPAR 163
                 R+++  E+  E  + +   ++E E    +N    E ++++W L E P SS  A+
Sbjct: 130 ESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLEKPNSSVAAK 189

Query: 164 IIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFF 223
           I+AI+S+M I++S ++  L TLP  +  +E                  + QST       
Sbjct: 190 ILAIISIMFIVLSTIALSLNTLPELQSLDE------------------FGQSTD-NPQLA 230

Query: 224 IVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQ 283
            VE +CI WF+ E+L+RF + P K  FF   +N ID++AI+PY++T+   L E  +   Q
Sbjct: 231 HVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIF--LTESNKSVLQ 288

Query: 284 GQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFS 343
            Q      ++++ R++R+ RI KL+RHS GLQ LG TL+ S  ELGLLI FL +G+++FS
Sbjct: 289 FQNVRR--VVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFS 346

Query: 344 SAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIA 403
           S V+FAE DE +++F SIP +FWWA ++MTTVGYGD+ P T+ GKIVG LC IAGVL IA
Sbjct: 347 SLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIA 406

Query: 404 LPVPVIVSNFNYFYHRETEGEEQAQYLQVTSCPKIPSS--PDLKKSRSASTISKSDYMEI 461
           LP+P+IV+NF+ FY  +   E+  +  +     K   S      K   A +I   D +  
Sbjct: 407 LPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVE 466

Query: 462 QEGVNNSNEDFREENLKTAN 481
           + G N   +D  ++N  + N
Sbjct: 467 KNGENMGKKDKVQDNHLSPN 486


>gi|27436981 potassium voltage-gated channel, Shal-related
           subfamily, member 1 [Homo sapiens]
          Length = 647

 Score =  275 bits (703), Expect = 7e-74
 Identities = 160/415 (38%), Positives = 242/415 (58%), Gaps = 51/415 (12%)

Query: 33  ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY 92
           E +V+N+SG RFET   TL ++P+TLLG  +K   ++D    EYFFDR+   F  +L +Y
Sbjct: 40  EVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEF-FYDADSGEYFFDRDPDMFRHVLNFY 98

Query: 93  QSGGRLRRPVNVPLDIFSEEIRFYEL-----GEEAMEMFREDEGYIKEEERPLPENE--- 144
           ++G RL  P    +  F EE+ FY L     G+  +E +R+ +   KE    L E+E   
Sbjct: 99  RTG-RLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRK---KENAERLAEDEEAE 154

Query: 145 -------------FQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDE 191
                         ++++W  FE P +S  A +   V+   I +S+++  +ET+P     
Sbjct: 155 QAGDGPALPAGSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIPC---- 210

Query: 192 NEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFF 251
                GS         S+        F   FF ++T C++ F+ E+L+R FA PS+  F 
Sbjct: 211 ----RGSA------RRSSREQPCGERFPQAFFCMDTACVLIFTGEYLLRLFAAPSRCRFL 260

Query: 252 TNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHS 311
            ++M++ID+VAI+PY+I L   L  K +D               +R+ RVFRIFK SRHS
Sbjct: 261 RSVMSLIDVVAILPYYIGL---LVPKNDDVS--------GAFVTLRVFRVFRIFKFSRHS 309

Query: 312 KGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVS 371
           +GL+ILG TLK+   ELG L+F L + +I+F++ +++AE    ++ F SIP AFW+ +V+
Sbjct: 310 QGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIPAAFWYTIVT 369

Query: 372 MTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQ 426
           MTT+GYGDMVP+TI GKI GS+C+++GVL IALPVPVIVSNF+  YH+    +++
Sbjct: 370 MTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKR 424


>gi|27436974 potassium voltage-gated channel, Shab-related
           subfamily, member 2 [Homo sapiens]
          Length = 911

 Score =  272 bits (695), Expect = 6e-73
 Identities = 164/438 (37%), Positives = 250/438 (57%), Gaps = 54/438 (12%)

Query: 19  PQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLR----- 73
           P +  D      C  RV IN+ GL  E   +TL + P T LG  +    +   L      
Sbjct: 21  PPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDY 80

Query: 74  ----NEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEI---------------- 113
               NEYFFDR+  +F +IL +Y++G +L     +    F +E+                
Sbjct: 81  NLNENEYFFDRHPGAFTSILNFYRTG-KLHMMEEMCALSFGQELDYWGIDEIYLESCCQA 139

Query: 114 RFYELGEEAMEMFREDEGYIKEEERPLPEN----EFQRQVWLLFEYPESSGPARIIAIVS 169
           R+++  E+  E  R +   ++E E    +N    + ++++W L E P SS  A+I+AIVS
Sbjct: 140 RYHQKKEQMNEELRREAETMREREGEEFDNTCCPDKRKKLWDLLEKPNSSVAAKILAIVS 199

Query: 170 VMVILISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLC 229
           ++ I++S ++  L TLP  ++ +E             N  + +            VE +C
Sbjct: 200 ILFIVLSTIALSLNTLPELQETDE-------FGQLNDNRQLAH------------VEAVC 240

Query: 230 IIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMS 289
           I WF+ E+L+RF + P+K  FF   +N+ID++AI+PY++T+   L E  +   Q Q    
Sbjct: 241 IAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIF--LTESNKSVLQFQNVRR 298

Query: 290 LAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFA 349
             ++++ R++R+ RI KL+RHS GLQ LG TL+ S  ELGLLI FL +G+++FSS V+FA
Sbjct: 299 --VVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFA 356

Query: 350 EADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVI 409
           E DE  ++F SIP +FWWA ++MTTVGYGD+ P T+ GKIVG LC IAGVL IALP+P+I
Sbjct: 357 EKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPII 416

Query: 410 VSNFNYFYHRETEGEEQA 427
           V+NF+ FY +E + +E+A
Sbjct: 417 VNNFSEFY-KEQKRQEKA 433


>gi|27436984 potassium voltage-gated channel, Shal-related
           subfamily, member 3 isoform 1 [Homo sapiens]
          Length = 655

 Score =  266 bits (679), Expect = 4e-71
 Identities = 151/409 (36%), Positives = 240/409 (58%), Gaps = 44/409 (10%)

Query: 33  ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY 92
           E +V+N+SG RF+T   TL ++P+TLLG  +K   +F+    EYFFDR+   F  +L +Y
Sbjct: 40  ELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEF-FFNEDTKEYFFDRDPEVFRCVLNFY 98

Query: 93  QSGGRLRRPVNVPLDIFSEEIRFYE-----LGEEAMEMFRE----------DEGYIKEEE 137
           ++ G+L  P    +  + +E+ FY      +G+   E +++          D+   +  +
Sbjct: 99  RT-GKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQ 157

Query: 138 RPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHG 197
             +P   F++ +W  FE P +S  A +   V+   I +S+++  +ET+P           
Sbjct: 158 ESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPC---------- 207

Query: 198 SGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNI 257
              T         G + S +    FF ++T C++ F+ E+L+R FA PS+  F  ++M+I
Sbjct: 208 --GTVPGSKELPCGERYSVA----FFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSI 261

Query: 258 IDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQIL 317
           ID+VAI+PY+I L               + +S A +  +R+ RVFRIFK SRHS+GL+IL
Sbjct: 262 IDVVAIMPYYIGL----------VMTNNEDVSGAFV-TLRVFRVFRIFKFSRHSQGLRIL 310

Query: 318 GQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGY 377
           G TLK+   ELG L+F L + +I+F++ +++AE     S+F SIP +FW+ +V+MTT+GY
Sbjct: 311 GYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGY 370

Query: 378 GDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQ 426
           GDMVP TI GKI GS+C+++GVL IALPVPVIVSNF+  YH+    +++
Sbjct: 371 GDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKR 419


>gi|27436986 potassium voltage-gated channel, Shal-related
           subfamily, member 3 isoform 2 [Homo sapiens]
          Length = 636

 Score =  266 bits (679), Expect = 4e-71
 Identities = 151/409 (36%), Positives = 240/409 (58%), Gaps = 44/409 (10%)

Query: 33  ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY 92
           E +V+N+SG RF+T   TL ++P+TLLG  +K   +F+    EYFFDR+   F  +L +Y
Sbjct: 40  ELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEF-FFNEDTKEYFFDRDPEVFRCVLNFY 98

Query: 93  QSGGRLRRPVNVPLDIFSEEIRFYE-----LGEEAMEMFRE----------DEGYIKEEE 137
           ++ G+L  P    +  + +E+ FY      +G+   E +++          D+   +  +
Sbjct: 99  RT-GKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQ 157

Query: 138 RPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHG 197
             +P   F++ +W  FE P +S  A +   V+   I +S+++  +ET+P           
Sbjct: 158 ESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPC---------- 207

Query: 198 SGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNI 257
              T         G + S +    FF ++T C++ F+ E+L+R FA PS+  F  ++M+I
Sbjct: 208 --GTVPGSKELPCGERYSVA----FFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSI 261

Query: 258 IDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQIL 317
           ID+VAI+PY+I L               + +S A +  +R+ RVFRIFK SRHS+GL+IL
Sbjct: 262 IDVVAIMPYYIGL----------VMTNNEDVSGAFV-TLRVFRVFRIFKFSRHSQGLRIL 310

Query: 318 GQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGY 377
           G TLK+   ELG L+F L + +I+F++ +++AE     S+F SIP +FW+ +V+MTT+GY
Sbjct: 311 GYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGY 370

Query: 378 GDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQ 426
           GDMVP TI GKI GS+C+++GVL IALPVPVIVSNF+  YH+    +++
Sbjct: 371 GDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKR 419


>gi|163792201 Shaw-related voltage-gated potassium channel protein 1
           isoform A [Homo sapiens]
          Length = 585

 Score =  265 bits (677), Expect = 7e-71
 Identities = 183/534 (34%), Positives = 276/534 (51%), Gaps = 83/534 (15%)

Query: 33  ERVVINISGLRFETQLKTLAQFPETLLG---DPKKRMRY-FDPLRNEYFFDRNRPSFDAI 88
           ER+VIN+ G R +T   TL   P T L    +P     + +DP  +E+FFDR+   F  I
Sbjct: 8   ERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHI 67

Query: 89  LYYYQSGGRLRRPVNVPLDIFSEEIRFYEL------------------GEEAMEMFRE-- 128
           L YY++G +L  P +V   ++ EE+ F+ +                   EEA++ F    
Sbjct: 68  LNYYRTG-KLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAP 126

Query: 129 --------------DEGYIKEEERPLPE---------------NEFQRQVWLLFEYPESS 159
                         D G  ++E                       +Q ++W LFE P SS
Sbjct: 127 LDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSS 186

Query: 160 GPARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFT 219
             AR +A  S+  IL+SI +FCLET   F   N  ++ + +  +  + + + Y +     
Sbjct: 187 RYARYVAFASLFFILVSITTFCLETHERF---NPIVNKTEIE-NVRNGTQVRYYREAETE 242

Query: 220 DPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTE--LAEK 277
                +E +C++WF+FEFL+R   CP+K  F  N +NIID VAI+P+++ +G     ++ 
Sbjct: 243 AFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKA 302

Query: 278 PEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFI 337
            +D         L  LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI FL +
Sbjct: 303 AKDV--------LGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLAL 354

Query: 338 GVILFSSAVYFAE---------ADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGK 388
           GV++F++ +Y+AE         +    + F +IP  FWWAVV+MTT+GYGDM P T  G 
Sbjct: 355 GVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGM 414

Query: 389 IVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQVTSCPKIP--SSPDLKK 446
           +VG+LCA+AGVLTIA+PVPVIV+NF  +Y      +++    +    P+ P   SP+  K
Sbjct: 415 LVGALCALAGVLTIAMPVPVIVNNFGMYYSL-AMAKQKLPKKKKKHIPRPPQLGSPNYCK 473

Query: 447 S--RSASTISKSDYMEI-QEGVNNSNEDFREENLKTANCTLANTNYVNITKMLT 497
           S   S    ++SD   + QE +   N    + N + A   LAN +  +I + LT
Sbjct: 474 SVVNSPHHSTQSDTCPLAQEEILEINRADSKLNGEVAKAALANEDCPHIDQALT 527


>gi|9789987 potassium voltage-gated channel, Shal-related subfamily,
           member 2 [Homo sapiens]
          Length = 630

 Score =  264 bits (675), Expect = 1e-70
 Identities = 162/477 (33%), Positives = 269/477 (56%), Gaps = 50/477 (10%)

Query: 35  VVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQS 94
           +V+N+SG RF+T   TL ++P+TLLG   +R  ++ P   +YFFDR+   F  IL +Y++
Sbjct: 43  IVLNVSGTRFQTWQDTLERYPDTLLGS-SERDFFYHPETQQYFFDRDPDIFRHILNFYRT 101

Query: 95  GGRLRRPVNVPLDIFSEEIRFYEL---------GEEAMEMFREDEGYIKEE-------ER 138
            G+L  P +  +  + EE+ F+ L          EE  +  RE+   ++++       E 
Sbjct: 102 -GKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDTAGES 160

Query: 139 PLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGS 198
            LP    +++VW  FE P +S  A +   V+   I +S+++  +ET+P            
Sbjct: 161 ALPTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVP-----------C 209

Query: 199 GVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNII 258
           G +         G + + +    FF ++T C++ F+ E+L+R  A PS+  F  ++M+II
Sbjct: 210 GSSPGHIKELPCGERYAVA----FFCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSII 265

Query: 259 DIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILG 318
           D+VAI+PY+I L               + +S A +  +R+ RVFRIFK SRHS+GL+ILG
Sbjct: 266 DVVAILPYYIGL----------VMTDNEDVSGAFV-TLRVFRVFRIFKFSRHSQGLRILG 314

Query: 319 QTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYG 378
            TLK+   ELG L+F L + +I+F++ +++AE     S+F SIP AFW+ +V+MTT+GYG
Sbjct: 315 YTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTIVTMTTLGYG 374

Query: 379 DMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHR-----ETEGEEQAQYLQVT 433
           DMVP TI GKI GS+C+++GVL IALPVPVIVSNF+  YH+     +   +++A+  ++ 
Sbjct: 375 DMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIR 434

Query: 434 SCPKIPSSPDLKKSRSASTISKSDYMEIQEG-VNNSNEDFREENLKTANCTLANTNY 489
           +     ++  ++  R+    ++    E ++  V+ S   F  ++    +C    TN+
Sbjct: 435 AAKSGSANAYMQSKRNGLLSNQLQSSEDEQAFVSKSGSSFETQHHHLLHCLEKTTNH 491


>gi|4826786 Shaw-related voltage-gated potassium channel protein 1
           isoform B [Homo sapiens]
          Length = 511

 Score =  261 bits (666), Expect = 1e-69
 Identities = 163/449 (36%), Positives = 241/449 (53%), Gaps = 77/449 (17%)

Query: 33  ERVVINISGLRFETQLKTLAQFPETLLG---DPKKRMRY-FDPLRNEYFFDRNRPSFDAI 88
           ER+VIN+ G R +T   TL   P T L    +P     + +DP  +E+FFDR+   F  I
Sbjct: 8   ERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHI 67

Query: 89  LYYYQSGGRLRRPVNVPLDIFSEEIRFYEL------------------GEEAMEMFRE-- 128
           L YY++G +L  P +V   ++ EE+ F+ +                   EEA++ F    
Sbjct: 68  LNYYRTG-KLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAP 126

Query: 129 --------------DEGYIKEEERPLPE---------------NEFQRQVWLLFEYPESS 159
                         D G  ++E                       +Q ++W LFE P SS
Sbjct: 127 LDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSS 186

Query: 160 GPARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFT 219
             AR +A  S+  IL+SI +FCLET   F   N  ++ + +  +  + + + Y +     
Sbjct: 187 RYARYVAFASLFFILVSITTFCLETHERF---NPIVNKTEIE-NVRNGTQVRYYREAETE 242

Query: 220 DPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTE--LAEK 277
                +E +C++WF+FEFL+R   CP+K  F  N +NIID VAI+P+++ +G     ++ 
Sbjct: 243 AFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKA 302

Query: 278 PEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFI 337
            +D         L  LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E  LLI FL +
Sbjct: 303 AKDV--------LGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLAL 354

Query: 338 GVILFSSAVYFAE---------ADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGK 388
           GV++F++ +Y+AE         +    + F +IP  FWWAVV+MTT+GYGDM P T  G 
Sbjct: 355 GVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGM 414

Query: 389 IVGSLCAIAGVLTIALPVPVIVSNFNYFY 417
           +VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 415 LVGALCALAGVLTIAMPVPVIVNNFGMYY 443


>gi|88758576 Shaw-related voltage-gated potassium channel protein 4
           isoform c [Homo sapiens]
          Length = 626

 Score =  258 bits (659), Expect = 9e-69
 Identities = 169/467 (36%), Positives = 245/467 (52%), Gaps = 93/467 (19%)

Query: 27  ADHECCERVVINISGLRFETQLKTLAQFPETLLG---DPKKRMRYFDPLRN--------- 74
           A  E  E+++IN+ G R ET   TL   P T L    DP    R   P  +         
Sbjct: 30  AKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGR---PETDGGGVGSSGS 86

Query: 75  ------EYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYEL---------- 118
                 E+FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ +          
Sbjct: 87  SGGGGCEFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELTFWGIDETDVEPCCW 145

Query: 119 --------GEEAMEMFREDEG---------YIKEEERPLPENE----------------- 144
                    EEA+++F   +G            ++ER L                     
Sbjct: 146 MTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGC 205

Query: 145 --FQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIF---RDENEDMHGSG 199
             +Q ++W LFE P SS  AR++A  S+  IL+SI +FCLET   F   R+  E +    
Sbjct: 206 RGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGN 265

Query: 200 VTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIID 259
           +T       ++ +++          +E +C++WF+ EFLVR   CP    F  N++NIID
Sbjct: 266 IT-------SVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIID 318

Query: 260 IVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQ 319
            VAI+P+++ +G  L+     A +      L  LRV+R VR+ RIFKL+RH  GL++LG 
Sbjct: 319 FVAILPFYLEVG--LSGLSSKAARDV----LGFLRVVRFVRILRIFKLTRHFVGLRVLGH 372

Query: 320 TLKASMRELGLLIFFLFIGVILFSSAVYFAE------ADER---ESQFPSIPDAFWWAVV 370
           TL+AS  E  LLI FL +GV++F++ +Y+AE      +D R    + F +IP  FWWAVV
Sbjct: 373 TLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVV 432

Query: 371 SMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 417
           +MTT+GYGDM P T  G +VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 433 TMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 479


>gi|24497462 Shaw-related voltage-gated potassium channel protein 4
           isoform a [Homo sapiens]
          Length = 635

 Score =  258 bits (659), Expect = 9e-69
 Identities = 169/467 (36%), Positives = 245/467 (52%), Gaps = 93/467 (19%)

Query: 27  ADHECCERVVINISGLRFETQLKTLAQFPETLLG---DPKKRMRYFDPLRN--------- 74
           A  E  E+++IN+ G R ET   TL   P T L    DP    R   P  +         
Sbjct: 30  AKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGR---PETDGGGVGSSGS 86

Query: 75  ------EYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYEL---------- 118
                 E+FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ +          
Sbjct: 87  SGGGGCEFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELTFWGIDETDVEPCCW 145

Query: 119 --------GEEAMEMFREDEG---------YIKEEERPLPENE----------------- 144
                    EEA+++F   +G            ++ER L                     
Sbjct: 146 MTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGC 205

Query: 145 --FQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIF---RDENEDMHGSG 199
             +Q ++W LFE P SS  AR++A  S+  IL+SI +FCLET   F   R+  E +    
Sbjct: 206 RGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGN 265

Query: 200 VTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIID 259
           +T       ++ +++          +E +C++WF+ EFLVR   CP    F  N++NIID
Sbjct: 266 IT-------SVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIID 318

Query: 260 IVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQ 319
            VAI+P+++ +G  L+     A +      L  LRV+R VR+ RIFKL+RH  GL++LG 
Sbjct: 319 FVAILPFYLEVG--LSGLSSKAARDV----LGFLRVVRFVRILRIFKLTRHFVGLRVLGH 372

Query: 320 TLKASMRELGLLIFFLFIGVILFSSAVYFAE------ADER---ESQFPSIPDAFWWAVV 370
           TL+AS  E  LLI FL +GV++F++ +Y+AE      +D R    + F +IP  FWWAVV
Sbjct: 373 TLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVV 432

Query: 371 SMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 417
           +MTT+GYGDM P T  G +VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 433 TMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 479


>gi|24497464 Shaw-related voltage-gated potassium channel protein 4
           isoform b [Homo sapiens]
          Length = 582

 Score =  258 bits (659), Expect = 9e-69
 Identities = 169/467 (36%), Positives = 245/467 (52%), Gaps = 93/467 (19%)

Query: 27  ADHECCERVVINISGLRFETQLKTLAQFPETLLG---DPKKRMRYFDPLRN--------- 74
           A  E  E+++IN+ G R ET   TL   P T L    DP    R   P  +         
Sbjct: 30  AKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGR---PETDGGGVGSSGS 86

Query: 75  ------EYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYEL---------- 118
                 E+FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ +          
Sbjct: 87  SGGGGCEFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELTFWGIDETDVEPCCW 145

Query: 119 --------GEEAMEMFREDEG---------YIKEEERPLPENE----------------- 144
                    EEA+++F   +G            ++ER L                     
Sbjct: 146 MTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGC 205

Query: 145 --FQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIF---RDENEDMHGSG 199
             +Q ++W LFE P SS  AR++A  S+  IL+SI +FCLET   F   R+  E +    
Sbjct: 206 RGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGN 265

Query: 200 VTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIID 259
           +T       ++ +++          +E +C++WF+ EFLVR   CP    F  N++NIID
Sbjct: 266 IT-------SVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIID 318

Query: 260 IVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQ 319
            VAI+P+++ +G  L+     A +      L  LRV+R VR+ RIFKL+RH  GL++LG 
Sbjct: 319 FVAILPFYLEVG--LSGLSSKAARDV----LGFLRVVRFVRILRIFKLTRHFVGLRVLGH 372

Query: 320 TLKASMRELGLLIFFLFIGVILFSSAVYFAE------ADER---ESQFPSIPDAFWWAVV 370
           TL+AS  E  LLI FL +GV++F++ +Y+AE      +D R    + F +IP  FWWAVV
Sbjct: 373 TLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVV 432

Query: 371 SMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 417
           +MTT+GYGDM P T  G +VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 433 TMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 479


>gi|21217561 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2a [Homo sapiens]
          Length = 613

 Score =  246 bits (628), Expect = 3e-65
 Identities = 157/399 (39%), Positives = 223/399 (55%), Gaps = 75/399 (18%)

Query: 75  EYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYEL---------------- 118
           E+FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ +                
Sbjct: 101 EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159

Query: 119 --GEEAMEMFR----------EDEGYIK-----EEERPL--PENE------FQRQVWLLF 153
              EEA+++F           +DE         E+   L  P+ +       Q ++W LF
Sbjct: 160 RDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALF 219

Query: 154 EYPESSGPARIIAIVSVMVILISIVSFCLETLPIF---RDENEDMHGSGVTFHTYSNSTI 210
           E P SS  AR IA  S+  IL+SI +FCLET   F   +++ E +           N T 
Sbjct: 220 EDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPV----------INGTS 269

Query: 211 GYQQSTSFTDPFFI-VETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFIT 269
              Q    TDP    VE +C++WF+FEFLVR    P+K  F  N++NIID VAI+P+++ 
Sbjct: 270 VVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLE 329

Query: 270 LGTE--LAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRE 327
           +G     ++  +D         L  LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E
Sbjct: 330 VGLSGLSSKAAKDV--------LGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNE 381

Query: 328 LGLLIFFLFIGVILFSSAVYFAE---------ADERESQFPSIPDAFWWAVVSMTTVGYG 378
             LLI FL +GV++F++ +Y+AE         +    +QF +IP  FWWAVV+MTT+GYG
Sbjct: 382 FLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYG 441

Query: 379 DMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 417
           DM P T  G +VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 442 DMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480


>gi|21217563 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2b [Homo sapiens]
          Length = 638

 Score =  246 bits (628), Expect = 3e-65
 Identities = 157/399 (39%), Positives = 223/399 (55%), Gaps = 75/399 (18%)

Query: 75  EYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYEL---------------- 118
           E+FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ +                
Sbjct: 101 EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159

Query: 119 --GEEAMEMFR----------EDEGYIK-----EEERPL--PENE------FQRQVWLLF 153
              EEA+++F           +DE         E+   L  P+ +       Q ++W LF
Sbjct: 160 RDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALF 219

Query: 154 EYPESSGPARIIAIVSVMVILISIVSFCLETLPIF---RDENEDMHGSGVTFHTYSNSTI 210
           E P SS  AR IA  S+  IL+SI +FCLET   F   +++ E +           N T 
Sbjct: 220 EDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPV----------INGTS 269

Query: 211 GYQQSTSFTDPFFI-VETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFIT 269
              Q    TDP    VE +C++WF+FEFLVR    P+K  F  N++NIID VAI+P+++ 
Sbjct: 270 VVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLE 329

Query: 270 LGTE--LAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRE 327
           +G     ++  +D         L  LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E
Sbjct: 330 VGLSGLSSKAAKDV--------LGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNE 381

Query: 328 LGLLIFFLFIGVILFSSAVYFAE---------ADERESQFPSIPDAFWWAVVSMTTVGYG 378
             LLI FL +GV++F++ +Y+AE         +    +QF +IP  FWWAVV+MTT+GYG
Sbjct: 382 FLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYG 441

Query: 379 DMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 417
           DM P T  G +VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 442 DMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480


>gi|24497458 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2c [Homo sapiens]
          Length = 558

 Score =  246 bits (628), Expect = 3e-65
 Identities = 157/399 (39%), Positives = 223/399 (55%), Gaps = 75/399 (18%)

Query: 75  EYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYEL---------------- 118
           E+FFDR+   F  +L YY++G +L  P +V   +F EE+ F+ +                
Sbjct: 101 EFFFDRHPGVFAYVLNYYRTG-KLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 159

Query: 119 --GEEAMEMFR----------EDEGYIK-----EEERPL--PENE------FQRQVWLLF 153
              EEA+++F           +DE         E+   L  P+ +       Q ++W LF
Sbjct: 160 RDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALF 219

Query: 154 EYPESSGPARIIAIVSVMVILISIVSFCLETLPIF---RDENEDMHGSGVTFHTYSNSTI 210
           E P SS  AR IA  S+  IL+SI +FCLET   F   +++ E +           N T 
Sbjct: 220 EDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPV----------INGTS 269

Query: 211 GYQQSTSFTDPFFI-VETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFIT 269
              Q    TDP    VE +C++WF+FEFLVR    P+K  F  N++NIID VAI+P+++ 
Sbjct: 270 VVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLE 329

Query: 270 LGTE--LAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRE 327
           +G     ++  +D         L  LRV+R VR+ RIFKL+RH  GL++LG TL+AS  E
Sbjct: 330 VGLSGLSSKAAKDV--------LGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNE 381

Query: 328 LGLLIFFLFIGVILFSSAVYFAE---------ADERESQFPSIPDAFWWAVVSMTTVGYG 378
             LLI FL +GV++F++ +Y+AE         +    +QF +IP  FWWAVV+MTT+GYG
Sbjct: 382 FLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYG 441

Query: 379 DMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 417
           DM P T  G +VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 442 DMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480


>gi|45383011 potassium voltage-gated channel, delayed-rectifier,
           subfamily S, member 2 [Homo sapiens]
          Length = 477

 Score =  233 bits (594), Expect = 3e-61
 Identities = 145/432 (33%), Positives = 228/432 (52%), Gaps = 72/432 (16%)

Query: 37  INISGLRFETQLKTLAQFPETLLGDPK---------KRMRYFDPLRNEYFFDRNRPSFDA 87
           IN+ G +   +  TL +FPET LG            +    +D ++ E++FDRN   F  
Sbjct: 21  INVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPY 80

Query: 88  ILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE-----------EAMEMFREDEGYIKEE 136
           +L++Y +G +L     + +  FS+EI ++ + E              ++  E E + ++ 
Sbjct: 81  VLHFYHTG-KLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQS 139

Query: 137 ERPL---------------------PENEFQRQVWLLFEYPESSGPARIIAIVSVMVILI 175
           ++                       P   F+RQ+WL  + P  S  +R+ +I+S++V++ 
Sbjct: 140 DQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVVMG 199

Query: 176 SIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFF-IVETLCIIWFS 234
           SI++ CL +LP F+                    I   Q     DP F IVE   I WF+
Sbjct: 200 SIITMCLNSLPDFQ--------------------IPDSQGNPGEDPRFEIVEHFGIAWFT 239

Query: 235 FEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEK--PEDAQQGQQAMSLAI 292
           FE + RF   P    FF N +N+ID+++I+P++ITL   L  +  P  A  G+ A     
Sbjct: 240 FELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTPTLANLGRVA----- 294

Query: 293 LRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAD 352
            +V+RL+R+FRI KL+RHS GL+ LG TLK S +E+GLL+ +L +G+ +FS   Y  E +
Sbjct: 295 -QVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKE 353

Query: 353 ERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSN 412
           E E    +IP  +WWA VSMTTVGYGD+VP T  GK+  S C +AG+L + LP+ +I + 
Sbjct: 354 ENEG-LATIPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNK 412

Query: 413 FNYFYHRETEGE 424
           F++FY R+ + E
Sbjct: 413 FSHFYRRQKQLE 424


>gi|20070166 potassium voltage-gated channel, subfamily F, member 1
           [Homo sapiens]
          Length = 494

 Score =  230 bits (587), Expect = 2e-60
 Identities = 142/434 (32%), Positives = 234/434 (53%), Gaps = 58/434 (13%)

Query: 35  VVINISGLRFETQLKTLAQFPETLLGDPKKRMRY-----------FDPLRNEYFFDRNRP 83
           +V+N+ G+R       L+Q+PET L +    +             +DP + E++FDR+  
Sbjct: 25  IVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDDYDPGKREFYFDRDPD 84

Query: 84  SFDAILYYYQSGGRLRRPVNVPL------DIFSEEIRFY---------ELGEEAMEMFRE 128
           +F  ++  Y  G    +    P+      D +  +++F          E  EE  E+ R 
Sbjct: 85  AFKCVIEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREELEEIARR 144

Query: 129 DEGYIKEEERPLPENEF---QRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETL 185
            +  + +      E  +   Q+ VW   E PESS PAR++A++S ++IL+S V  C+ T+
Sbjct: 145 VQLILDDLGVDAAEGRWRRCQKCVWKFLEKPESSCPARVVAVLSFLLILVSSVVMCMGTI 204

Query: 186 PIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACP 245
           P    +  D  G+ V   T  N                 VET CI WF+ E+L+R F+ P
Sbjct: 205 PEL--QVLDAEGNRVEHPTLEN-----------------VETACIGWFTLEYLLRLFSSP 245

Query: 246 SKAGFFTNIMNIIDIVAIIPYFITLG-TELAEKPEDAQQGQQAMSLAILRVIRLVRVFRI 304
           +K  F  + MNI+D++AI+P++++L  T L  +  +    QQA+     + +R++R+ RI
Sbjct: 246 NKLHFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQAV-----QALRIMRIARI 300

Query: 305 FKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDA 364
           FKL+RHS GLQ L   LK S +ELGLL+ +L +G+ +FS+  Y  E    E+ F SIP +
Sbjct: 301 FKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSALGYTMEQSHPETLFKSIPQS 360

Query: 365 FWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHR----E 420
           FWWA+++MTTVGYGD+ P T  GK+  ++  + GV+ IALP+  I++NF  +Y++    E
Sbjct: 361 FWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNFVRYYNKQRVLE 420

Query: 421 TEGEEQAQYLQVTS 434
           T  + + + +++ S
Sbjct: 421 TAAKHELELMELNS 434


>gi|13492973 potassium voltage-gated channel delayed-rectifier
           protein S1 [Homo sapiens]
          Length = 526

 Score =  229 bits (585), Expect = 3e-60
 Identities = 150/479 (31%), Positives = 244/479 (50%), Gaps = 62/479 (12%)

Query: 33  ERVVINISGLRFETQLKTLAQFPETLLG---------DPKKRMRYFDPLRNEYFFDRNRP 83
           E + +N+ G+R +   + LA+FP T LG           ++    +D    E++FDR+  
Sbjct: 50  EALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPG 109

Query: 84  SFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMF--------REDEGYIKE 135
            F ++L++Y++G  L     + +  F +E  ++ LGE A+           R  + +  +
Sbjct: 110 FFLSLLHFYRTG-HLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWD 168

Query: 136 EERPLPEN------------------------EFQRQVWLLFEYPESSGPARIIAIVSVM 171
           E+   P +                          +R++WL  E P  S P+++ + VS+ 
Sbjct: 169 EDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSIS 228

Query: 172 VILISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFI-VETLCI 230
           V+L SI + C+ +LP ++        + V       S  G +      DP    +E  CI
Sbjct: 229 VVLASIAAMCIHSLPEYQAREA---AAAVAAVAAGRSPEGVRD-----DPVLRRLEYFCI 280

Query: 231 IWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSL 290
            WFSFE   R    PS   FF + +N+IDIV+++P+++TL   LA      Q G++   L
Sbjct: 281 AWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTL---LAGVALGDQGGKEFGHL 337

Query: 291 A-ILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFA 349
             +++V RL+R+FR+ KL+RHS GL+ LG TLK S RE+G+L+ +L +GV +FS   Y A
Sbjct: 338 GKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTA 397

Query: 350 EADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVI 409
           E +E +  F +IP  +WW  VSMTTVGYGD+VP T+ GK+  S C + G+L +ALP+ +I
Sbjct: 398 EKEE-DVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITII 456

Query: 410 VSNFNYFYHRE------TEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQ 462
            + F++FY R+             ++  + S     S   L+ SR  S   +S  +E Q
Sbjct: 457 FNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSIDGVSEASLETSRETSQEGQSADLESQ 515


>gi|24497460 Shaw-related voltage-gated potassium channel protein 3
           [Homo sapiens]
          Length = 757

 Score =  229 bits (583), Expect = 6e-60
 Identities = 132/289 (45%), Positives = 180/289 (62%), Gaps = 30/289 (10%)

Query: 145 FQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGVTFHT 204
           +Q +VW LFE P SS  AR +A  S+  ILISI +FCLET   F      +H S  T   
Sbjct: 272 WQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGF------IHISNKTVTQ 325

Query: 205 YSNSTIGYQQSTSF----TDPFFI-VETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIID 259
            S       ++ +     T+PF   VE +C++WF+FEFL+R   CP K  F  + +NIID
Sbjct: 326 ASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIID 385

Query: 260 IVAIIPYFITLGTE--LAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQIL 317
            VAI+P+++ +G     ++  +D         L  LRV+R VR+ RIFKL+RH  GL++L
Sbjct: 386 CVAILPFYLEVGLSGLSSKAAKDV--------LGFLRVVRFVRILRIFKLTRHFVGLRVL 437

Query: 318 GQTLKASMRELGLLIFFLFIGVILFSSAVYFAE---AD------ERESQFPSIPDAFWWA 368
           G TL+AS  E  LLI FL +GV++F++ +Y+AE   AD         + F +IP  FWWA
Sbjct: 438 GHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWA 497

Query: 369 VVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 417
           VV+MTT+GYGDM P T  G +VG+LCA+AGVLTIA+PVPVIV+NF  +Y
Sbjct: 498 VVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 546



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 35/95 (36%), Positives = 56/95 (58%), Gaps = 5/95 (5%)

Query: 34  RVVINISGLRFETQLKTLAQFPETLLG---DPKKRMRY-FDPLRNEYFFDRNRPSFDAIL 89
           ++VIN+ G+R ET   TL   P T L    +P+   R+ +DP  +E+FFDR+   F  +L
Sbjct: 89  KIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGADEFFFDRHPGVFAYVL 148

Query: 90  YYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAME 124
            YY++G +L  P +V   +F EE+ F+ + E  +E
Sbjct: 149 NYYRTG-KLHCPADVCGPLFEEELGFWGIDETDVE 182


>gi|25952108 potassium voltage-gated channel delayed-rectifier
           protein S3 [Homo sapiens]
          Length = 491

 Score =  222 bits (565), Expect = 7e-58
 Identities = 138/432 (31%), Positives = 222/432 (51%), Gaps = 70/432 (16%)

Query: 33  ERVVINISGLRFETQLKTLAQFPETLLG------DPKKRMRYFDPLR---NEYFFDRNRP 83
           E V +N+ G +      TL +FP T LG        +  +   D       EY+FDRN  
Sbjct: 15  ELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPS 74

Query: 84  SFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMF-------REDEGYIKE- 135
            F  +L +Y +G +L     + +  F +EI ++ + E  ++         R++E + K+ 
Sbjct: 75  LFRYVLNFYYTG-KLHVMEELCVFSFCQEIEYWGINELFIDSCCSNRYQERKEENHEKDW 133

Query: 136 -------------EERPLPENEFQR-----------QVWLLFEYPESSGPARIIAIVSVM 171
                        EE  L E E ++           ++W+  E P     A++IAI S+ 
Sbjct: 134 DQKSHDVSTDSSFEESSLFEKELEKFDTLRFGQLRKKIWIRMENPAYCLSAKLIAISSLS 193

Query: 172 VILISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFI-VETLCI 230
           V+L SIV+ C+ ++  F++E+ ++                        DP    VE  CI
Sbjct: 194 VVLASIVAMCVHSMSEFQNEDGEVD-----------------------DPVLEGVEIACI 230

Query: 231 IWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSL 290
            WF+ E  VR  A P +  F+ N +NIID V+IIP++ TL  +  E+  +  +       
Sbjct: 231 AWFTGELAVRLAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEESEDIENMGK--- 287

Query: 291 AILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE 350
            +++++RL+R+FRI KL+RHS GL+ LG TL+ S  E+GLL+ FL +G+ +FS  +Y  E
Sbjct: 288 -VVQILRLMRIFRILKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSVLIYSVE 346

Query: 351 ADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIV 410
            D+  S   SIP  +WWA +SMTTVGYGD  P T+ GK++ S C I G+L +ALP+ +I 
Sbjct: 347 KDDHTSSLTSIPICWWWATISMTTVGYGDTHPVTLAGKLIASTCIICGILVVALPITIIF 406

Query: 411 SNFNYFYHRETE 422
           + F+ +Y ++ +
Sbjct: 407 NKFSKYYQKQKD 418


>gi|27436988 potassium voltage-gated channel, subfamily G, member 1
           [Homo sapiens]
          Length = 513

 Score =  218 bits (555), Expect = 1e-56
 Identities = 140/436 (32%), Positives = 224/436 (51%), Gaps = 60/436 (13%)

Query: 34  RVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLR---------NEYFFDRNRPS 84
           R++IN+ G+++     TL +FP T LG  K    + D L          NE+FFDRN  +
Sbjct: 64  RIIINVGGIKYSLPWTTLDEFPLTRLGQLKACTNFDDILNVCDDYDVTCNEFFFDRNPGA 123

Query: 85  FDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAME-----------------MFR 127
           F  IL + ++G +LR    +    F EE+ ++ + E+ ++                 + R
Sbjct: 124 FGTILTFLRAG-KLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMVER 182

Query: 128 EDEGYIKEEERPLPENEFQ---------RQVWLLFEYPESSGPARIIAIVSVMVILISIV 178
           E+E    + E    E   +         R++  + E P S  P ++ A +SV+ + ++ V
Sbjct: 183 EEEDDALDSEGRDSEGPAEGEGRLGRCMRRLRDMVERPHSGLPGKVFACLSVLFVTVTAV 242

Query: 179 SFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFL 238
           +  + TLP  R+E E  H S +  +                   FIVE++C+ WFS EFL
Sbjct: 243 NLSVSTLPSLREEEEQGHCSQMCHNV------------------FIVESVCVGWFSLEFL 284

Query: 239 VRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELA----EKPEDAQQGQQAMSLAILR 294
           +R    PSK  F  + + +ID+VAI+PY+ITL  + A     KP         + L +LR
Sbjct: 285 LRLIQAPSKFAFLRSPLTLIDLVAILPYYITLLVDGAAAGRRKPGAGNSYLDKVGL-VLR 343

Query: 295 VIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADER 354
           V+R +R+  + +L+RHS GLQ LG T +   RE GLL+ FL + + LF+  +Y  E +  
Sbjct: 344 VLRALRILYVMRLARHSLGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIENEMA 403

Query: 355 ES-QFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNF 413
           +S +F SIP  +WWAV++MTTVGYGDMVP +  G++V     ++G+L +A PV  I   F
Sbjct: 404 DSPEFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFHTF 463

Query: 414 NYFYHRETEGEEQAQY 429
           +  Y    + +E+  +
Sbjct: 464 SRSYLELKQEQERVMF 479


>gi|27436996 potassium voltage-gated channel, subfamily G, member 4
           [Homo sapiens]
          Length = 519

 Score =  213 bits (543), Expect = 2e-55
 Identities = 137/434 (31%), Positives = 218/434 (50%), Gaps = 58/434 (13%)

Query: 33  ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRY---------FDPLRNEYFFDRNRP 83
           + ++IN+ G R+     TL +FP + L   +    Y         +D    E+FFDR+  
Sbjct: 59  KEILINVGGRRYLLPWSTLDRFPLSRLSKLRLCRSYEEIVQLCDDYDEDSQEFFFDRSPS 118

Query: 84  SFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAME------------------- 124
           +F  I+ +  +G  +       L  F EE+ ++ + E  +E                   
Sbjct: 119 AFGVIVSFLAAGKLVLLQEMCALS-FQEELAYWGIEEAHLERCCLRKLLRKLEELEELAK 177

Query: 125 MFREDE-GYIKEEERPLPENE----FQRQVWLLFEYPESSGPARIIAIVSVMVILISIVS 179
           + RED     +E  RP   +        ++  + E P+S  P ++ A +S++ +  + VS
Sbjct: 178 LHREDVLRQQRETRRPASHSSRWGLCMNRLREMVENPQSGLPGKVFACLSILFVATTAVS 237

Query: 180 FCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLV 239
            C+ T+P  R E +    S   ++                   FIVET+C+ WFS EF +
Sbjct: 238 LCVSTMPDLRAEEDQGECSRKCYY------------------IFIVETICVAWFSLEFCL 279

Query: 240 RFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLA----ILRV 295
           RF     K  FF   +NIIDI+AI PY+++L     E PED ++   +  L     +LRV
Sbjct: 280 RFVQAQDKCQFFQGPLNIIDILAISPYYVSLAVS-EEPPEDGERPSGSSYLEKVGLVLRV 338

Query: 296 IRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADE-R 354
           +R +R+  + +L+RHS GLQ LG T++   RE GLL+ FL + + LFS  VY AE +  R
Sbjct: 339 LRALRILYVMRLARHSLGLQTLGLTVRRCTREFGLLLLFLAVAITLFSPLVYVAEKESGR 398

Query: 355 ESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFN 414
             +F SIP ++WWA++SMTTVGYGDMVP ++ G++V     ++G+L +A P   I   F+
Sbjct: 399 VLEFTSIPASYWWAIISMTTVGYGDMVPRSVPGQMVALSSILSGILIMAFPATSIFHTFS 458

Query: 415 YFYHRETEGEEQAQ 428
           + Y    + +EQ Q
Sbjct: 459 HSYLELKKEQEQLQ 472


>gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]
          Length = 500

 Score =  211 bits (537), Expect = 1e-54
 Identities = 133/424 (31%), Positives = 218/424 (51%), Gaps = 74/424 (17%)

Query: 37  INISGLRFETQLKTLAQFPETLLG-------------------DPKKRMRYFDPLRNEYF 77
           +N+ G RF    + L+ FP T LG                    P +     +P+ NEYF
Sbjct: 43  VNVGGSRFVLSQQALSCFPHTRLGKLAVVVASYRRPGALAAVPSPLELCDDANPVDNEYF 102

Query: 78  FDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEE- 136
           FDR+  +F  +L+YY++G RL     +    F +EI+++ + E +++    D  + ++E 
Sbjct: 103 FDRSSQAFRYVLHYYRTG-RLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKEL 161

Query: 137 ------ERPLPENEFQRQ----------------VWLLFEYPESSGPARIIAIVSVMVIL 174
                 ++   + E Q +                +W + E P SS  ARI  ++S++ ++
Sbjct: 162 SETLDFKKDTEDQESQHESEQDFSQGPCPTVRQKLWNILEKPGSSTAARIFGVISIIFVV 221

Query: 175 ISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFS 234
           +SI++  L +  +                    S +  Q          I+E +CI WF+
Sbjct: 222 VSIINMALMSAEL--------------------SWLDLQLLE-------ILEYVCISWFT 254

Query: 235 FEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLA-IL 293
            EF++RF     +  F   + NIID++AI+P++ITL   L E    +Q  Q+  ++  I+
Sbjct: 255 GEFVLRFLCVRDRCRFLRKVPNIIDLLAILPFYITL---LVESLSGSQTTQELENVGRIV 311

Query: 294 RVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADE 353
           +V+RL+R  R+ KL RHS GL+ LG T+     E+GLL+ FL +G+ +FS+  YFAE   
Sbjct: 312 QVLRLLRALRMLKLGRHSTGLRSLGMTITQCYEEVGLLLLFLSVGISIFSTVEYFAEQSI 371

Query: 354 RESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNF 413
            ++ F S+P A+WWA  SMTTVGYGD+ P T  GKIV  +C ++G+L +ALP+ +I   F
Sbjct: 372 PDTTFTSVPCAWWWATTSMTTVGYGDIRPDTTTGKIVAFMCILSGILVLALPIAIINDRF 431

Query: 414 NYFY 417
           +  Y
Sbjct: 432 SACY 435


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.410 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,304,269
Number of Sequences: 37866
Number of extensions: 806043
Number of successful extensions: 2584
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 155
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 2036
Number of HSP's gapped (non-prelim): 369
length of query: 499
length of database: 18,247,518
effective HSP length: 106
effective length of query: 393
effective length of database: 14,233,722
effective search space: 5593852746
effective search space used: 5593852746
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.