Guide to the Human Genome
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Search of human proteins with 4826702

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo
sapiens]
         (840 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens]  1705   0.0  
gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo sapi...  1684   0.0  
gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo sapi...   855   0.0  
gi|13435364 desmocollin 2 isoform Dsc2a preproprotein [Homo sapi...   834   0.0  
gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo sap...   822   0.0  
gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo sap...   808   0.0  
gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens]           429   e-120
gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens]           388   e-107
gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens]            380   e-105
gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens]           334   2e-91
gi|4502719 cadherin 13 preproprotein [Homo sapiens]                   307   3e-83
gi|197313787 desmoglein 4 isoform 1 [Homo sapiens]                    303   6e-82
gi|29789445 desmoglein 4 isoform 2 [Homo sapiens]                     303   6e-82
gi|116534898 desmoglein 2 preproprotein [Homo sapiens]                298   1e-80
gi|4826669 cadherin 15 preproprotein [Homo sapiens]                   297   3e-80
gi|29570800 cadherin-like 26 isoform a [Homo sapiens]                 293   5e-79
gi|119964718 desmoglein 3 preproprotein [Homo sapiens]                281   1e-75
gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens]           275   1e-73
gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens]           275   1e-73
gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens]           270   3e-72
gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens]          259   9e-69
gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens]          252   1e-66
gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens]          246   8e-65
gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens]          245   1e-64
gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens]           245   1e-64
gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens]            231   2e-60
gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens]           227   4e-59
gi|32880203 cadherin-like 24 isoform 2 [Homo sapiens]                 218   1e-56
gi|16753221 cadherin 22 precursor [Homo sapiens]                      218   2e-56
gi|119703744 desmoglein 1 preproprotein [Homo sapiens]                218   2e-56

>gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens]
          Length = 840

 Score = 1705 bits (4415), Expect = 0.0
 Identities = 840/840 (100%), Positives = 840/840 (100%)

Query: 1   MALASAAPGSIFCKQLLFSLLVLTLLCDACQKVYLRVPSHLQAETLVGKVNLEECLKSAS 60
           MALASAAPGSIFCKQLLFSLLVLTLLCDACQKVYLRVPSHLQAETLVGKVNLEECLKSAS
Sbjct: 1   MALASAAPGSIFCKQLLFSLLVLTLLCDACQKVYLRVPSHLQAETLVGKVNLEECLKSAS 60

Query: 61  LIRSSDPAFRILEDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEIKVVLSARENKSPK 120
           LIRSSDPAFRILEDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEIKVVLSARENKSPK
Sbjct: 61  LIRSSDPAFRILEDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEIKVVLSARENKSPK 120

Query: 121 KRHTKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKE 180
           KRHTKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKE
Sbjct: 121 KRHTKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKE 180

Query: 181 PFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAP 240
           PFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAP
Sbjct: 181 PFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAP 240

Query: 241 YFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDT 300
           YFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDT
Sbjct: 241 YFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDT 300

Query: 301 GVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYV 360
           GVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYV
Sbjct: 301 GVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYV 360

Query: 361 TEVEENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVK 420
           TEVEENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVK
Sbjct: 361 TEVEENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVK 420

Query: 421 PLNYEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQS 480
           PLNYEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQS
Sbjct: 421 PLNYEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQS 480

Query: 481 QDGFPAGQELLGYKALDPEISSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFV 540
           QDGFPAGQELLGYKALDPEISSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFV
Sbjct: 481 QDGFPAGQELLGYKALDPEISSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFV 540

Query: 541 KNNQYNISVVAVDAVGRSCTGTLVVHLDDYNDHAPQIDKEVTICQNNEDFAVLKPVDPDG 600
           KNNQYNISVVAVDAVGRSCTGTLVVHLDDYNDHAPQIDKEVTICQNNEDFAVLKPVDPDG
Sbjct: 541 KNNQYNISVVAVDAVGRSCTGTLVVHLDDYNDHAPQIDKEVTICQNNEDFAVLKPVDPDG 600

Query: 601 PENGPPFQFFLDNSASKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKDRHGLVATHML 660
           PENGPPFQFFLDNSASKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKDRHGLVATHML
Sbjct: 601 PENGPPFQFFLDNSASKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKDRHGLVATHML 660

Query: 661 TVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCILFTCFCVTAKRTV 720
           TVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCILFTCFCVTAKRTV
Sbjct: 661 TVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCILFTCFCVTAKRTV 720

Query: 721 KKCFPEDIAQQNLIVSNTEGPGEEVTEANIRLPMQTSNICDTSMSVGTVGGQGIKTQQSF 780
           KKCFPEDIAQQNLIVSNTEGPGEEVTEANIRLPMQTSNICDTSMSVGTVGGQGIKTQQSF
Sbjct: 721 KKCFPEDIAQQNLIVSNTEGPGEEVTEANIRLPMQTSNICDTSMSVGTVGGQGIKTQQSF 780

Query: 781 EMVKGGYTLDSNKGGGHQTLESVKGVGQGDTGRYAYTDWQSFTQPRLGEESIRGHTLIKN 840
           EMVKGGYTLDSNKGGGHQTLESVKGVGQGDTGRYAYTDWQSFTQPRLGEESIRGHTLIKN
Sbjct: 781 EMVKGGYTLDSNKGGGHQTLESVKGVGQGDTGRYAYTDWQSFTQPRLGEESIRGHTLIKN 840


>gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo
           sapiens]
          Length = 894

 Score = 1684 bits (4360), Expect = 0.0
 Identities = 829/830 (99%), Positives = 830/830 (100%)

Query: 1   MALASAAPGSIFCKQLLFSLLVLTLLCDACQKVYLRVPSHLQAETLVGKVNLEECLKSAS 60
           MALASAAPGSIFCKQLLFSLLVLTLLCDACQKVYLRVPSHLQAETLVGKVNLEECLKSAS
Sbjct: 1   MALASAAPGSIFCKQLLFSLLVLTLLCDACQKVYLRVPSHLQAETLVGKVNLEECLKSAS 60

Query: 61  LIRSSDPAFRILEDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEIKVVLSARENKSPK 120
           LIRSSDPAFRILEDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEIKVVLSARENKSPK
Sbjct: 61  LIRSSDPAFRILEDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEIKVVLSARENKSPK 120

Query: 121 KRHTKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKE 180
           KRHTKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKE
Sbjct: 121 KRHTKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKE 180

Query: 181 PFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAP 240
           PFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAP
Sbjct: 181 PFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAP 240

Query: 241 YFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDT 300
           YFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDT
Sbjct: 241 YFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDT 300

Query: 301 GVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYV 360
           GVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYV
Sbjct: 301 GVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYV 360

Query: 361 TEVEENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVK 420
           TEVEENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVK
Sbjct: 361 TEVEENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVK 420

Query: 421 PLNYEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQS 480
           PLNYEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQS
Sbjct: 421 PLNYEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQS 480

Query: 481 QDGFPAGQELLGYKALDPEISSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFV 540
           QDGFPAGQELLGYKALDPEISSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFV
Sbjct: 481 QDGFPAGQELLGYKALDPEISSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFV 540

Query: 541 KNNQYNISVVAVDAVGRSCTGTLVVHLDDYNDHAPQIDKEVTICQNNEDFAVLKPVDPDG 600
           KNNQYNISVVAVDAVGRSCTGTLVVHLDDYNDHAPQIDKEVTICQNNEDFAVLKPVDPDG
Sbjct: 541 KNNQYNISVVAVDAVGRSCTGTLVVHLDDYNDHAPQIDKEVTICQNNEDFAVLKPVDPDG 600

Query: 601 PENGPPFQFFLDNSASKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKDRHGLVATHML 660
           PENGPPFQFFLDNSASKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKDRHGLVATHML
Sbjct: 601 PENGPPFQFFLDNSASKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKDRHGLVATHML 660

Query: 661 TVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCILFTCFCVTAKRTV 720
           TVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCILFTCFCVTAKRTV
Sbjct: 661 TVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCILFTCFCVTAKRTV 720

Query: 721 KKCFPEDIAQQNLIVSNTEGPGEEVTEANIRLPMQTSNICDTSMSVGTVGGQGIKTQQSF 780
           KKCFPEDIAQQNLIVSNTEGPGEEVTEANIRLPMQTSNICDTSMSVGTVGGQGIKTQQSF
Sbjct: 721 KKCFPEDIAQQNLIVSNTEGPGEEVTEANIRLPMQTSNICDTSMSVGTVGGQGIKTQQSF 780

Query: 781 EMVKGGYTLDSNKGGGHQTLESVKGVGQGDTGRYAYTDWQSFTQPRLGEE 830
           EMVKGGYTLDSNKGGGHQTLESVKGVGQGDTGRYAYTDWQSFTQPRLGE+
Sbjct: 781 EMVKGGYTLDSNKGGGHQTLESVKGVGQGDTGRYAYTDWQSFTQPRLGEK 830


>gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo
           sapiens]
          Length = 847

 Score =  855 bits (2209), Expect = 0.0
 Identities = 450/850 (52%), Positives = 590/850 (69%), Gaps = 17/850 (2%)

Query: 2   ALASAAPGSIFCKQLLFSLLVLTLLCDACQKVYLRVPSHLQAETLVGKVNLEECLKSASL 61
           A  S +     C+ LL +L +L    DAC+ V L VPS L AE LVG+VNL+EC  +A+L
Sbjct: 4   ARPSGSWNGALCRLLLLTLAILIFASDACKNVTLHVPSKLDAEKLVGRVNLKECFTAANL 63

Query: 62  IRSSDPAFRILEDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEIKVVLSARENKSPKK 121
           I SSDP F+ILEDGS+YTT+ ++LSSE++SF+I LS+ + +E+++I V L   + K  KK
Sbjct: 64  IHSSDPDFQILEDGSVYTTNTILLSSEKRSFTILLSNTENQEKKKIFVFLE-HQTKVLKK 122

Query: 122 RHTKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEP 181
           RHTK+  L+R+KRRWAPIP S++ENSLGPFP  +QQ+QSD AQNYTI+YSI GPGVD+EP
Sbjct: 123 RHTKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEP 182

Query: 182 FNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPY 241
            NLFY+E+DTG+++CTR +DRE+YE F +  +ATT DGY PE PLPLIIKIED+NDN P 
Sbjct: 183 RNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPI 242

Query: 242 FEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDTG 301
           F      FT+ ENCR GT+VG+V ATD DEPDT+HTRLKY I+ Q+P  P  FS+HP TG
Sbjct: 243 FTEETYTFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTG 302

Query: 302 VITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVT 361
           VITTT+  LDRE  D YQL ++V+DM GQ FGL  T T  I+++D ND+ P+FT TSYVT
Sbjct: 303 VITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVT 362

Query: 362 EVEENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKP 421
            VEEN +DVEILR+ V+D+DL NT + +A Y IL+GNENGNF I TD  TNEGVLCVVKP
Sbjct: 363 SVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKP 422

Query: 422 LNYEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQ 481
           LNYE  +Q+ILQ+GV+NEA FS+ AS ++  M T TVTV + D DEGPEC+PP++ ++ +
Sbjct: 423 LNYEEKQQMILQIGVVNEAPFSREASPRS-AMSTATVTVNVEDQDEGPECNPPIQTVRMK 481

Query: 482 DGFPAGQELLGYKALDPEISSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFVK 541
           +    G    GYKA DPE  S  G+RY+KL D   W  I+++TG ++  + LDRE++ +K
Sbjct: 482 ENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIK 541

Query: 542 NNQYNISVVAVDAVGRSCTGTLVVHLDDYNDHAPQIDKE-VTICQNNEDFAVLKPVDPDG 600
           N  YNI+V+A D  GR+CTGTL + L D ND++P I K+ V IC+     A +  VDPD 
Sbjct: 542 NGIYNITVLASDQGGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVAVDPDE 601

Query: 601 PENGPPFQFFLDNSAS---KNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKDRHGLVAT 657
           P +GPPF F L++S S   + W ++  +   A L  + +  +  Y VPI ++DR G+ + 
Sbjct: 602 PIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSSV 661

Query: 658 HMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCILFTCFC-VTA 716
             L V +CDC T ++C  +    R     V LG+WAILA++LG  LL CILFT  C  + 
Sbjct: 662 TSLDVTLCDCITENDCTHR-VDPRIGGGGVQLGKWAILAILLGIALLFCILFTLVCGASG 720

Query: 717 KRTVKKCFPEDIAQQNLIVSNTEGPGEE-VTEANIRLPMQTSNICDTSMSVGTVGGQGIK 775
                K  P+D+AQQNLIVSNTE PG++ V  AN      T  +  ++  V    G GIK
Sbjct: 721 TSKQPKVIPDDLAQQNLIVSNTEAPGDDKVYSAN---GFTTQTVGASAQGVCGTVGSGIK 777

Query: 776 T--QQSFEMVKGGY-TLDSNKGGG-HQTLESVK-GVGQGDTGRYAYTDWQSFTQPRLGEE 830
              Q++ EMVKGG+ T +S +G G H TL+S + G  + D  RY Y++W SFTQPRLGEE
Sbjct: 778 NGGQETIEMVKGGHQTSESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEE 837

Query: 831 SIRGHTLIKN 840
           SIRGHTLIKN
Sbjct: 838 SIRGHTLIKN 847


>gi|13435364 desmocollin 2 isoform Dsc2a preproprotein [Homo
           sapiens]
          Length = 901

 Score =  834 bits (2154), Expect = 0.0
 Identities = 439/840 (52%), Positives = 580/840 (69%), Gaps = 17/840 (2%)

Query: 2   ALASAAPGSIFCKQLLFSLLVLTLLCDACQKVYLRVPSHLQAETLVGKVNLEECLKSASL 61
           A  S +     C+ LL +L +L    DAC+ V L VPS L AE LVG+VNL+EC  +A+L
Sbjct: 4   ARPSGSWNGALCRLLLLTLAILIFASDACKNVTLHVPSKLDAEKLVGRVNLKECFTAANL 63

Query: 62  IRSSDPAFRILEDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEIKVVLSARENKSPKK 121
           I SSDP F+ILEDGS+YTT+ ++LSSE++SF+I LS+ + +E+++I V L   + K  KK
Sbjct: 64  IHSSDPDFQILEDGSVYTTNTILLSSEKRSFTILLSNTENQEKKKIFVFLE-HQTKVLKK 122

Query: 122 RHTKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEP 181
           RHTK+  L+R+KRRWAPIP S++ENSLGPFP  +QQ+QSD AQNYTI+YSI GPGVD+EP
Sbjct: 123 RHTKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEP 182

Query: 182 FNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPY 241
            NLFY+E+DTG+++CTR +DRE+YE F +  +ATT DGY PE PLPLIIKIED+NDN P 
Sbjct: 183 RNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPI 242

Query: 242 FEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDTG 301
           F      FT+ ENCR GT+VG+V ATD DEPDT+HTRLKY I+ Q+P  P  FS+HP TG
Sbjct: 243 FTEETYTFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTG 302

Query: 302 VITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVT 361
           VITTT+  LDRE  D YQL ++V+DM GQ FGL  T T  I+++D ND+ P+FT TSYVT
Sbjct: 303 VITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVT 362

Query: 362 EVEENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKP 421
            VEEN +DVEILR+ V+D+DL NT + +A Y IL+GNENGNF I TD  TNEGVLCVVKP
Sbjct: 363 SVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKP 422

Query: 422 LNYEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQ 481
           LNYE  +Q+ILQ+GV+NEA FS+ AS ++  M T TVTV + D DEGPEC+PP++ ++ +
Sbjct: 423 LNYEEKQQMILQIGVVNEAPFSREASPRS-AMSTATVTVNVEDQDEGPECNPPIQTVRMK 481

Query: 482 DGFPAGQELLGYKALDPEISSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFVK 541
           +    G    GYKA DPE  S  G+RY+KL D   W  I+++TG ++  + LDRE++ +K
Sbjct: 482 ENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIK 541

Query: 542 NNQYNISVVAVDAVGRSCTGTLVVHLDDYNDHAPQIDKE-VTICQNNEDFAVLKPVDPDG 600
           N  YNI+V+A D  GR+CTGTL + L D ND++P I K+ V IC+     A +  VDPD 
Sbjct: 542 NGIYNITVLASDQGGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVAVDPDE 601

Query: 601 PENGPPFQFFLDNSAS---KNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKDRHGLVAT 657
           P +GPPF F L++S S   + W ++  +   A L  + +  +  Y VPI ++DR G+ + 
Sbjct: 602 PIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSSV 661

Query: 658 HMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCILFTCFC-VTA 716
             L V +CDC T ++C  +    R     V LG+WAILA++LG  LL CILFT  C  + 
Sbjct: 662 TSLDVTLCDCITENDCTHR-VDPRIGGGGVQLGKWAILAILLGIALLFCILFTLVCGASG 720

Query: 717 KRTVKKCFPEDIAQQNLIVSNTEGPGEE-VTEANIRLPMQTSNICDTSMSVGTVGGQGIK 775
                K  P+D+AQQNLIVSNTE PG++ V  AN      T  +  ++  V    G GIK
Sbjct: 721 TSKQPKVIPDDLAQQNLIVSNTEAPGDDKVYSAN---GFTTQTVGASAQGVCGTVGSGIK 777

Query: 776 T--QQSFEMVKGGY-TLDSNKGGG-HQTLESVK-GVGQGDTGRYAYTDWQSFTQPRLGEE 830
              Q++ EMVKGG+ T +S +G G H TL+S + G  + D  RY Y++W SFTQPRLGE+
Sbjct: 778 NGGQETIEMVKGGHQTSESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEK 837


>gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo
           sapiens]
          Length = 839

 Score =  822 bits (2123), Expect = 0.0
 Identities = 428/834 (51%), Positives = 576/834 (69%), Gaps = 20/834 (2%)

Query: 13  CKQLLFSLLVLTLLCDACQKVYLRVPSHLQAETLVGKVNLEECLKSASLIRSSDPAFRIL 72
           C  LL +L++ +   +AC+KV L VPS L+A+ ++G+VNLEEC +SA LIRSSDP FR+L
Sbjct: 15  CLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRSSDPDFRVL 74

Query: 73  EDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEIKVVLSARENKSPKKRHTKDTALKRS 132
            DGS+YT   + LS +++SF+I+LSD +++ Q+E+ V+L   + K  K RHT++T L+R+
Sbjct: 75  NDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLE-HQKKVSKTRHTRETVLRRA 133

Query: 133 KRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFNLFYIEKDTG 192
           KRRWAPIP S+ ENSLGPFP  +QQ++SDAAQNYT+FYSISG GVDKEP NLFYIE+DTG
Sbjct: 134 KRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTG 193

Query: 193 DIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFEHRVTIFTVP 252
           ++FCTR +DRE+Y+ F L  YA+TADGY+ + PLPL I++ED+NDN P F   +  F V 
Sbjct: 194 NLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEVL 253

Query: 253 ENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDTGVITTTTPFLDR 312
           E+ R GT+VG V ATD DEPDT+HTRLKY ILQQ P  P  FS+HP TGVITT + +LDR
Sbjct: 254 ESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDR 313

Query: 313 EKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEENRIDVEI 372
           E  D Y LIM+V+DM GQ FGL  T T  I++ D NDN P+F + +Y   VEEN  +VEI
Sbjct: 314 EVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEI 373

Query: 373 LRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYEVNRQVIL 432
           LR+ ++D+DL NT + +  + IL+GNENG+F ISTD  TNEGVL VVKPLNYE NRQV L
Sbjct: 374 LRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENRQVNL 433

Query: 433 QVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPAGQELLG 492
           ++GV NEA F++     T  +    VTV + D DEGPEC P  + ++ ++    G ++ G
Sbjct: 434 EIGVNNEAPFARDIPRVT-ALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKING 492

Query: 493 YKALDPEISSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNNQYNISVVAV 552
           YKA DPE  +G GLRY+KL D   W  I++ +G + T K+LDRE +  KN  YNI+V+A+
Sbjct: 493 YKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNITVLAI 552

Query: 553 DAVGRSCTGTLVVHLDDYNDHAPQIDKE-VTICQNNEDFAVLKPVDPDGPENGPPFQFFL 611
           D   RSCTGTL V+++D ND+ P+I +E V IC+    +  +  VDPD P +G PF F L
Sbjct: 553 DKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGAPFYFSL 612

Query: 612 DNSA---SKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKDRHGLVATHMLTVRVCDCS 668
            N++   S+ W++ + +   A L  ++N  +  Y++PI +KDR G  AT +L V +C+C+
Sbjct: 613 PNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECT 672

Query: 669 TPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCILFTCFCVTAKRTVKKCFPEDI 728
            P++CR   +ST      VILG+WAILA++LG  LL  +L T  C     T  K FPED+
Sbjct: 673 HPTQCRATSRST-----GVILGKWAILAILLGIALLFSVLLTLVCGVFGATKGKRFPEDL 727

Query: 729 AQQNLIVSNTEGPGEE-VTEANIRLPMQTSNICDTSMSVGTVGGQGIKT--QQSFEMVKG 785
           AQQNLI+SNTE PG++ V  AN  +   T+N   +S       G G+K   Q++ EM+KG
Sbjct: 728 AQQNLIISNTEAPGDDRVCSANGFMTQTTNN---SSQGFCGTMGSGMKNGGQETIEMMKG 784

Query: 786 G-YTLDSNKGGG-HQTLESVK-GVGQGDTGRYAYTDWQSFTQPRLGEESIRGHT 836
           G  TL+S +G G H TL+S + G  + D  RY Y++W SFTQPRLGEESIRGHT
Sbjct: 785 GNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEESIRGHT 838


>gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo
           sapiens]
          Length = 896

 Score =  808 bits (2087), Expect = 0.0
 Identities = 421/828 (50%), Positives = 570/828 (68%), Gaps = 20/828 (2%)

Query: 13  CKQLLFSLLVLTLLCDACQKVYLRVPSHLQAETLVGKVNLEECLKSASLIRSSDPAFRIL 72
           C  LL +L++ +   +AC+KV L VPS L+A+ ++G+VNLEEC +SA LIRSSDP FR+L
Sbjct: 15  CLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRSSDPDFRVL 74

Query: 73  EDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEIKVVLSARENKSPKKRHTKDTALKRS 132
            DGS+YT   + LS +++SF+I+LSD +++ Q+E+ V+L   + K  K RHT++T L+R+
Sbjct: 75  NDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLE-HQKKVSKTRHTRETVLRRA 133

Query: 133 KRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFNLFYIEKDTG 192
           KRRWAPIP S+ ENSLGPFP  +QQ++SDAAQNYT+FYSISG GVDKEP NLFYIE+DTG
Sbjct: 134 KRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTG 193

Query: 193 DIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFEHRVTIFTVP 252
           ++FCTR +DRE+Y+ F L  YA+TADGY+ + PLPL I++ED+NDN P F   +  F V 
Sbjct: 194 NLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEVL 253

Query: 253 ENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDTGVITTTTPFLDR 312
           E+ R GT+VG V ATD DEPDT+HTRLKY ILQQ P  P  FS+HP TGVITT + +LDR
Sbjct: 254 ESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDR 313

Query: 313 EKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEENRIDVEI 372
           E  D Y LIM+V+DM GQ FGL  T T  I++ D NDN P+F + +Y   VEEN  +VEI
Sbjct: 314 EVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEI 373

Query: 373 LRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYEVNRQVIL 432
           LR+ ++D+DL NT + +  + IL+GNENG+F ISTD  TNEGVL VVKPLNYE NRQV L
Sbjct: 374 LRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENRQVNL 433

Query: 433 QVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPAGQELLG 492
           ++GV NEA F++     T  +    VTV + D DEGPEC P  + ++ ++    G ++ G
Sbjct: 434 EIGVNNEAPFARDIPRVT-ALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKING 492

Query: 493 YKALDPEISSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNNQYNISVVAV 552
           YKA DPE  +G GLRY+KL D   W  I++ +G + T K+LDRE +  KN  YNI+V+A+
Sbjct: 493 YKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNITVLAI 552

Query: 553 DAVGRSCTGTLVVHLDDYNDHAPQIDKE-VTICQNNEDFAVLKPVDPDGPENGPPFQFFL 611
           D   RSCTGTL V+++D ND+ P+I +E V IC+    +  +  VDPD P +G PF F L
Sbjct: 553 DKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGAPFYFSL 612

Query: 612 DNSA---SKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKDRHGLVATHMLTVRVCDCS 668
            N++   S+ W++ + +   A L  ++N  +  Y++PI +KDR G  AT +L V +C+C+
Sbjct: 613 PNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECT 672

Query: 669 TPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCILFTCFCVTAKRTVKKCFPEDI 728
            P++CR   +ST      VILG+WAILA++LG  LL  +L T  C     T  K FPED+
Sbjct: 673 HPTQCRATSRST-----GVILGKWAILAILLGIALLFSVLLTLVCGVFGATKGKRFPEDL 727

Query: 729 AQQNLIVSNTEGPGEE-VTEANIRLPMQTSNICDTSMSVGTVGGQGIKT--QQSFEMVKG 785
           AQQNLI+SNTE PG++ V  AN  +   T+N   +S       G G+K   Q++ EM+KG
Sbjct: 728 AQQNLIISNTEAPGDDRVCSANGFMTQTTNN---SSQGFCGTMGSGMKNGGQETIEMMKG 784

Query: 786 G-YTLDSNKGGG-HQTLESVK-GVGQGDTGRYAYTDWQSFTQPRLGEE 830
           G  TL+S +G G H TL+S + G  + D  RY Y++W SFTQPRLGE+
Sbjct: 785 GNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEK 832


>gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens]
          Length = 906

 Score =  429 bits (1103), Expect = e-120
 Identities = 267/717 (37%), Positives = 392/717 (54%), Gaps = 44/717 (6%)

Query: 64  SSDPA-FRILEDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEIKVVLSARENKS---- 118
           SS+PA F++ EDG +Y      LSSE   F I+  D + +E+ ++ V LS +   +    
Sbjct: 73  SSEPADFKVDEDGMVYAVRSFPLSSEHAKFLIYAQDKETQEKWQVAVKLSLKPTLTEESV 132

Query: 119 -----------PKKRHTKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYT 167
                      P++       L+R KR W   P +L ENS GPFPQ + +I+SD  +N +
Sbjct: 133 KESAEVEEIVFPRQFSKHSGHLQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLS 192

Query: 168 IFYSISGPGVDKEPFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLP 227
           + YS++GPG D+ P  +F I   +G +  T+ +DRE+  +F L  +A   +G   E P+ 
Sbjct: 193 LRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDREQIARFHLRAHAVDINGNQVENPID 252

Query: 228 LIIKIEDDNDNAPYFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQI 287
           ++I + D NDN P F H+V   TVPE  + GT V  VTA D D+P+ L+  L+Y+I+ Q 
Sbjct: 253 IVINVIDMNDNRPEFLHQVWNGTVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRIVSQA 312

Query: 288 PD--HPKHFSIHPDTGVITTTTPFLDREKCDTYQLIMEVRDMGGQP-FGLFNTGTITISL 344
           P    P  F+I+ +TG I T    LDREK   Y LI++  DM G P +GL NT T  I++
Sbjct: 313 PSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITV 372

Query: 345 EDENDNPPSFTETSYVTEVEENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFI 404
            D NDNPP FT  ++  EV ENR+D+ +  + V D+D P+TP   AVY+I  G+  G F 
Sbjct: 373 TDVNDNPPEFTAMTFYGEVPENRVDIIVANLTVTDKDQPHTPAWNAVYRISGGDPTGRFA 432

Query: 405 ISTDPNTNEGVLCVVKPLNYEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIID 464
           I TDPN+N+G++ VVKP+++E NR  +L V   N+   +K    Q P   T TV+V +ID
Sbjct: 433 IQTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGI--QHPPQSTATVSVTVID 490

Query: 465 SDEGPECHPPVKVIQSQDGFPAGQELLGYKALDPEISSGEGLRYQKLGDEDNWFEINQHT 524
            +E P   P  K+I+ ++G  AG  L  + A DP+    + +RY KL D  NW +I+   
Sbjct: 491 VNENPYFAPNPKIIRQEEGLHAGTMLTTFTAQDPDRYMQQNIRYTKLSDPANWLKIDPVN 550

Query: 525 GDLRTLKVLDRESKFVKNNQYNISVVAVD--AVGRSCTGTLVVHLDDYNDHAPQI-DKEV 581
           G + T+ VLDRES  VKNN YN + +A D      S TGTL ++L D ND+APQ+  +E 
Sbjct: 551 GQITTIAVLDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEA 610

Query: 582 TICQNNEDFAV-LKPVDPDGPENGPPFQFFLDNS---ASKNWNIEEKDGKTAILRQR-QN 636
             C+  +  ++ +  +D D   N  PF F L  S     +NW I   +G  A L  + + 
Sbjct: 611 ETCETPDPNSINITALDYDIDPNAGPFAFDLPLSPVTIKRNWTITRLNGDFAQLNLKIKF 670

Query: 637 LDYNYYSVPIQIKDRHGLVATH--MLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAI 694
           L+   Y VPI I D      ++  +L V+VC C +  +C   D+          LG  AI
Sbjct: 671 LEAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIV-----GAGLGTGAI 725

Query: 695 LAMVLGSVLLLCILFTCFCVTAKRTVKK-------CFPEDIAQQNLIVSNTEGPGEE 744
           +A++L  +++L IL   F V  KR  K+         PED  + N++  + EG GEE
Sbjct: 726 IAILL-CIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEE 781


>gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens]
          Length = 916

 Score =  388 bits (996), Expect = e-107
 Identities = 257/752 (34%), Positives = 394/752 (52%), Gaps = 57/752 (7%)

Query: 41  LQAETLVGKVNLEECLKS-ASLIRSSDPAFRILEDGSIYTTHDLILSSERKSFSIFLSDG 99
           L+ E L+ +V    C+ +  +   ++   F++  DG+++ T +L + SE+ +F++   D 
Sbjct: 49  LEGEKLL-QVKFSSCVGTKGTQYETNSMDFKVGADGTVFATRELQVPSEQVAFTVTAWDS 107

Query: 100 QRREQQEIKVVLSARENKSPKKRHT----------------KDT-----------ALKRS 132
           Q  E+ +  V L   +  SP   H                 KDT            L+R 
Sbjct: 108 QTAEKWDAVVRLLVAQTSSPHSGHKPQKGKKVVALDPSPPPKDTLLPWPQHQNANGLRRR 167

Query: 133 KRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFNLFYIEKDTG 192
           KR W   P ++ ENS GPFPQ + +I+SD   +  I YSI+G G D+ P  +F I+  +G
Sbjct: 168 KRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFSIDSMSG 227

Query: 193 DIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFEHRVTIFTVP 252
            ++ TR +DRE++  + L  +A   +G   E P+ L I + D NDN P F ++V   +V 
Sbjct: 228 RMYVTRPMDREEHASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVD 287

Query: 253 ENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKH--FSIHPDTGVITTTTPFL 310
           E  + GT V  VTA D D+  T +  ++Y+I+ Q P  P    F+I+ +TG I T    L
Sbjct: 288 EGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAGL 347

Query: 311 DREKCDTYQLIMEVRDM-GGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEENRID 369
           DREK   Y +I++  DM G   +GL NT T  I++ D NDNPP FT +++  EV ENR++
Sbjct: 348 DREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAGEVPENRVE 407

Query: 370 VEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYEVNRQ 429
             +  + V D+D P++P+  AVY+I+ G+ +G+F + TDP TNEG++ VVK ++YE+NR 
Sbjct: 408 TVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYELNRA 467

Query: 430 VILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPAGQE 489
            +L V V N+A    A+  Q     T  VT+ I+D +E P      K+I+ ++G P G  
Sbjct: 468 FMLTVMVSNQAPL--ASGIQMSFQSTAGVTISIMDINEAPYFPSNHKLIRLEEGVPPGTV 525

Query: 490 LLGYKALDPEISSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNNQYNISV 549
           L  + A+DP+    + +RY KL D  +W  IN   G + T  VLDRES + KNN Y  + 
Sbjct: 526 LTTFSAVDPDRFMQQAVRYSKLSDPASWLHINATNGQITTAAVLDRESLYTKNNVYEATF 585

Query: 550 VAVD--AVGRSCTGTLVVHLDDYNDHAPQ-IDKEVTICQN-NEDFAVLKPVDPDGPENGP 605
           +A D      S TGTL ++L D ND+AP+ + KE  IC+  N +   +   D D   N  
Sbjct: 586 LAADNGIPPASGTGTLQIYLIDINDNAPELLPKEAQICEKPNLNAINITAADADVDPNIG 645

Query: 606 PFQF---FLDNSASKNWNIEEKDGKTAILRQR-QNLDYNYYSVPIQIKDRHG--LVATHM 659
           P+ F   F+  +  KNW I   +G  A L  R   L+   Y VPI + D     L  T +
Sbjct: 646 PYVFELPFVPAAVRKNWTITRLNGDYAQLSLRILYLEAGMYDVPIIVTDSGNPPLSNTSI 705

Query: 660 LTVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCILFTCFCVTAKRT 719
           + V+VC C    +C     +T        LG  AI+A+++  +L+L  +   F +  KR 
Sbjct: 706 IKVKVCPCDDNGDC-----TTIGAVAAAGLGTGAIVAILI-CILILLTMVLLFVMWMKRR 759

Query: 720 VKK-------CFPEDIAQQNLIVSNTEGPGEE 744
            K+         PED  + N++  + EG GEE
Sbjct: 760 EKERHTKQLLIDPEDDVRDNILKYDEEGGGEE 791


>gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens]
          Length = 882

 Score =  380 bits (976), Expect = e-105
 Identities = 261/777 (33%), Positives = 389/777 (50%), Gaps = 56/777 (7%)

Query: 8   PGSIFCKQLLFSLLVLTLLC----------DACQKVYLRVPSHLQAETLVGKVNLEECL- 56
           P S     LL  L V + LC          DA    +     HL+   ++G+VN E+C  
Sbjct: 3   PWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTG 62

Query: 57  KSASLIRSSDPAFRILEDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEIKVVLSAREN 116
           +  +   S D  F++  DG I     L   + +  F ++  D   R+    KV L+   +
Sbjct: 63  RQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFST-KVTLNTVGH 121

Query: 117 KSPKKRHTKDTA---------------LKRSKRRWAPIPASLMENSLGPFPQHVQQIQSD 161
                 H    +               L+R KR W   P S  EN  GPFP+++ QI+S+
Sbjct: 122 HHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSN 181

Query: 162 AAQNYTIFYSISGPGVDKEPFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYA 221
             +   +FYSI+G G D  P  +F IE++TG +  T  +DRE+   + L+ +A +++G A
Sbjct: 182 KDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNA 241

Query: 222 PEYPLPLIIKIEDDNDNAPYFEHRVTIFTVPENCRSGTSVGKVTATDLDEP-DTLHTRLK 280
            E P+ ++I + D NDN P F   V   +V E    GTSV +VTATD D+  +T +  + 
Sbjct: 242 VEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIA 301

Query: 281 YKILQQIPDHP--KHFSIHPDTGVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTG 338
           Y IL Q P+ P    F+I+ +TGVI+  T  LDRE   TY L+++  D+ G+  GL  T 
Sbjct: 302 YTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGE--GLSTTA 359

Query: 339 TITISLEDENDNPPSFTETSYVTEVEENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGN 398
           T  I++ D NDNPP F  T+Y  +V EN  +V I  +KV D D PNTP  +AVY IL  +
Sbjct: 360 TAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTDADAPNTPAWEAVYTIL-ND 418

Query: 399 ENGNFIISTDPNTNEGVLCVVKPLNYEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTV 458
           + G F+++T+P  N+G+L   K L++E  +Q IL V V N   F  +      T  T TV
Sbjct: 419 DGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSL-----TTSTATV 473

Query: 459 TVKIIDSDEGPECHPPVKVIQSQDGFPAGQELLGYKALDPEISSGEGLRYQKLGDEDNWF 518
           TV ++D +E P   PP K ++  + F  GQE+  Y A +P+    + + Y+   D  NW 
Sbjct: 474 TVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWL 533

Query: 519 EINQHTGDLRTLKVLDRES-KFVKNNQYNISVVAVD--AVGRSCTGTLVVHLDDYNDHAP 575
           EIN  TG + T   LDRE  + VKN+ Y   ++A D  +   + TGTL++ L D ND+AP
Sbjct: 534 EINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAP 593

Query: 576 QID-KEVTICQNNEDFAVLKPVDPDGPENGPPFQFFLDNSASKNWNIEEKD--GKTAILR 632
             + + +  C+ N    V+  +D D P N  PF   L + AS NW I+  D   ++ IL+
Sbjct: 594 IPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILK 653

Query: 633 QRQNLDYNYYSVPIQIKDRHGLVATHMLTVRVCDC-STPSECRMKDKSTRDVRPNVILGR 691
            +  L+   Y + +++ D         L V VCDC      CR        ++   ILG 
Sbjct: 654 PKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILG- 712

Query: 692 WAILAMVLGSVLLLCILFTCFCVTAKR--TVKKCF--PEDIAQQNLIVSNTEGPGEE 744
                 +LG +L L IL     +  +R   VK+    PED  + N+   + EG GEE
Sbjct: 713 ------ILGGILALLILILLLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEE 763


>gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens]
          Length = 829

 Score =  334 bits (856), Expect = 2e-91
 Identities = 220/652 (33%), Positives = 331/652 (50%), Gaps = 40/652 (6%)

Query: 115 ENKSPKKRHTKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISG 174
           + ++P K       L+R KR W   P S+ EN  GPFPQ + Q++S+  ++  IFYSI+G
Sbjct: 88  KERNPLKIFPSKRILRRHKRDWVVAPISVPENGKGPFPQRLNQLKSNKDRDTKIFYSITG 147

Query: 175 PGVDKEPFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIED 234
           PG D  P  +F +EK+TG +   + +DRE+  ++ L+G+A + +G + E P+ + I + D
Sbjct: 148 PGADSPPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTD 207

Query: 235 DNDNAPYFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTR---LKYKILQQIPDHP 291
            ND+ P F       +V E    GTSV +VTAT  DE D ++T    + Y I  Q P  P
Sbjct: 208 QNDHKPKFTQDTFRGSVLEGVLPGTSVMQVTAT--DEDDAIYTYNGVVAYSIHSQEPKDP 265

Query: 292 KH--FSIHPDTGVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDEND 349
               F+IH  TG I+  +  LDREK   Y L ++  DM G   G   T    + + D ND
Sbjct: 266 HDLMFTIHRSTGTISVISSGLDREKVPEYTLTIQATDMDGD--GSTTTAVAVVEILDAND 323

Query: 350 NPPSFTETSYVTEVEENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDP 409
           N P F    Y   V EN +  E+ R+ V D D PN+P  +A Y I+ G++  +F I+T P
Sbjct: 324 NAPMFDPQKYEAHVPENAVGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHP 383

Query: 410 NTNEGVLCVVKPLNYEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGP 469
            +N+G+L   K L++E   Q  L V V NEA F      + PT  T T+ V + D +E P
Sbjct: 384 ESNQGILTTRKGLDFEAKNQHTLYVEVTNEAPF----VLKLPT-STATIVVHVEDVNEAP 438

Query: 470 ECHPPVKVIQSQDGFPAGQELLGYKALDPEISSGEGLRYQKLGDEDNWFEINQHTGDLRT 529
              PP KV++ Q+G P G+ +  Y A DP+    + + Y+ L D   W  ++  +G +  
Sbjct: 439 VFVPPSKVVEVQEGIPTGEPVCVYTAEDPD-KENQKISYRILRDPAGWLAMDPDSGQVTA 497

Query: 530 LKVLDRE-SKFVKNNQYNISVVAVD--AVGRSCTGTLVVHLDDYNDHAPQID-KEVTICQ 585
           +  LDRE  +FV+NN Y + V+A+D  +   + TGTL++ L D NDH P  + +++TIC 
Sbjct: 498 VGTLDREDEQFVRNNIYEVMVLAMDNGSPPTTGTGTLLLTLIDVNDHGPVPEPRQITICN 557

Query: 586 NNEDFAVLKPVDPDGPENGPPFQFFLDNSASKNWNIE-EKDGKTAILRQRQNLDYNYYSV 644
            +    VL   D D   +  PFQ  L + +   W  E  ++G T +L  ++ L  + Y V
Sbjct: 558 QSPVRQVLNITDKDLSPHTSPFQAQLTDDSDIYWTAEVNEEGDTVVLSLKKFLKQDTYDV 617

Query: 645 PIQIKDRHGLVATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRW--AILAMVLGSV 702
            + + D        ++   VCDC    E                 G W    +  VLG+V
Sbjct: 618 HLSLSDHGNKEQLTVIRATVCDCHGHVE--------------TCPGPWKGGFILPVLGAV 663

Query: 703 --LLLCILFTCFCVTAKRTVKK--CFPEDIAQQNLIVSNTEGPGEEVTEANI 750
             LL  +L     V  KR +K+    PED  + N+     EG GEE  + +I
Sbjct: 664 LALLFLLLVLLLLVRKKRKIKEPLLLPEDDTRDNVFYYGEEGGGEEDQDYDI 715


>gi|4502719 cadherin 13 preproprotein [Homo sapiens]
          Length = 713

 Score =  307 bits (786), Expect = 3e-83
 Identities = 212/657 (32%), Positives = 337/657 (51%), Gaps = 27/657 (4%)

Query: 31  QKVY-LRVPSHLQAETLVGKVNLEECLKSASL-IRSSDPAFRILEDGSIYTTHDLILSSE 88
           QKV+ +  P+    +  +  +   +C  +  L    S P F++  DG +    ++  ++ 
Sbjct: 33  QKVFHINQPAEFIEDQSILNLTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNI--TAV 90

Query: 89  RKSFSIFLSDGQRREQQEIKVVLSARENKSPKK---RHTKDTALKRSKRRWAPIPASLME 145
            K+  +        +  E+ V++  ++ +   +   +  + + + R KR     P  + E
Sbjct: 91  GKTLFVHARTPHAEDMAEL-VIVGGKDIQGSLQDIFKFARTSPVPRQKRSIVVSPILIPE 149

Query: 146 NSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFNLFYIEKDTGDIFCTRSIDREKY 205
           N   PFP+ V ++  D+ +     + ++G GVD+EP  +F I ++TG +  TR++DRE  
Sbjct: 150 NQRQPFPRDVGKVV-DSDRPERSKFRLTGKGVDQEPKGIFRINENTGSVSVTRTLDREVI 208

Query: 206 EQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFEHRVTIFTVPENCRSGTSVGKVT 265
             + L+   T  +G   E P+PL + + D NDN P F     I  V E   +GT+V ++T
Sbjct: 209 AVYQLFVETTDVNGKTLEGPVPLEVIVIDQNDNRPIFREGPYIGHVMEGSPTGTTVMRMT 268

Query: 266 ATDLDEPDTLHTRLKYKILQQIPDHPKH--FSIHPDTG-VITTTTP-FLDREKCDT--YQ 319
           A D D+P T +  L+Y I QQ PD P    F I P+ G ++T  +P  LDRE  +   Y+
Sbjct: 269 AFDADDPATDNALLRYNIRQQTPDKPSPNMFYIDPEKGDIVTVVSPALLDRETLENPKYE 328

Query: 320 LIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEENRIDVEILRMKVQD 379
           LI+E +DM G   GL  T T TI ++D+ND+ P FT+  +   VEE  + V I+ + V+D
Sbjct: 329 LIIEAQDMAGLDVGLTGTATATIMIDDKNDHSPKFTKKEFQATVEEGAVGV-IVNLTVED 387

Query: 380 QDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYEVNRQVILQVGVINE 439
           +D P T   +A Y I+ GN   +F I T+P TNEG+L VVKPL+YE++    L + V NE
Sbjct: 388 KDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKPLDYEISAFHTLLIKVENE 447

Query: 440 AQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPAGQELLGYKALDPE 499
                  S    +  T TV + ++D +EGP  +P   ++  Q+    G  LL   A DP+
Sbjct: 448 DPLVPDVSYGPSS--TATVHITVLDVNEGPVFYPDPMMVTRQEDLSVGSVLLTVNATDPD 505

Query: 500 ISSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNNQYNISVVAVDAVGRSC 559
               + +RY    D   W  IN   G + T  VLDRES FV N+ Y    +A+D+     
Sbjct: 506 SLQHQTIRYSVYKDPAGWLNINPINGTVDTTAVLDRESPFVDNSVYTALFLAIDSGNPPA 565

Query: 560 TGT--LVVHLDDYNDHAPQIDKEVT-ICQNNEDFAV--LKPVDPDGPENGPPFQFFLDNS 614
           TGT  L++ L+D ND+AP I   V  +C + ++ +V  L   D D   N  PF+F +   
Sbjct: 566 TGTGTLLITLEDVNDNAPFIYPTVAEVCDDAKNLSVVILGASDKDLHPNTDPFKFEIHKQ 625

Query: 615 A--SKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKDRHGLVATHM--LTVRVCDC 667
           A   K W I + +   A++   QNL+   Y++PI + D      T++  L V+VC C
Sbjct: 626 AVPDKVWKISKINNTHALVSLLQNLNKANYNLPIMVTDSGKPPMTNITDLRVQVCSC 682


>gi|197313787 desmoglein 4 isoform 1 [Homo sapiens]
          Length = 1059

 Score =  303 bits (775), Expect = 6e-82
 Identities = 206/623 (33%), Positives = 311/623 (49%), Gaps = 39/623 (6%)

Query: 124 TKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFN 183
           TK   ++R KR W    A+  E         + +I+SD   N  I Y ISG G+D+ P+ 
Sbjct: 39  TKWQTVRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYG 98

Query: 184 LFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFE 243
           +F I   TG+I  T  +DRE    F +Y  A  + G   E PL L +K+ D NDNAP F 
Sbjct: 99  VFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFS 158

Query: 244 HRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDTGVI 303
             V   ++ EN  + T V K+ ATD DE + L++++ YKI+ Q P     F ++  TG +
Sbjct: 159 QSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEV 218

Query: 304 TTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEV 363
            T + FLDRE+   Y L++   D  G   GL +     I + D NDN P+  +TSY   +
Sbjct: 219 CTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASI 278

Query: 364 EENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLN 423
           EEN +  E++R++  D D   T +  A Y IL GN+   F I TDP TNEG+L VVK L+
Sbjct: 279 EENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLD 338

Query: 424 YEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDG 483
           YE    + L +GV N+A F  + +SQ   M  T V ++++D  EGP  HP       ++G
Sbjct: 339 YEQAPNIQLSIGVKNQADFHYSVASQF-QMHPTPVRIQVVDVREGPAFHPSTMAFSVREG 397

Query: 484 FPAGQELLG-----YKALDPEISS-GEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRES 537
              G  LL      Y A+D +  +    +RY    D  +W +I+  TG+++  +  D++S
Sbjct: 398 I-KGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKS 456

Query: 538 KFVKNNQYNISVVAV-DAVGRSCTGTLVVHLDDYNDHAPQIDKE-VTICQNNEDFAVLKP 595
           K++ N  Y   ++A+ D  G++ TGT+ + + D ND+ P I  E  TIC ++   +VL  
Sbjct: 457 KYIINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICIDSP--SVLIS 514

Query: 596 VDPDGPENGPPFQFFLDN---SASKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKDRH 652
           V+      G PF F + +     +  W++   +  +AIL  +Q L   +Y +PI +KD +
Sbjct: 515 VNEH--SYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPILVKDSY 572

Query: 653 GLVA--THMLTVRVCDCSTPSECRMKDKS---TRDVR--------------PNVILGRWA 693
                   M+ +  CDC     C     +   T D+                NV LG   
Sbjct: 573 NRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGPAG 632

Query: 694 ILAMVLGSVLLL---CILFTCFC 713
           I  MVLG +LL+    +L  C C
Sbjct: 633 IGMMVLGILLLILAPLLLLLCCC 655


>gi|29789445 desmoglein 4 isoform 2 [Homo sapiens]
          Length = 1040

 Score =  303 bits (775), Expect = 6e-82
 Identities = 206/623 (33%), Positives = 311/623 (49%), Gaps = 39/623 (6%)

Query: 124 TKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFN 183
           TK   ++R KR W    A+  E         + +I+SD   N  I Y ISG G+D+ P+ 
Sbjct: 39  TKWQTVRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYG 98

Query: 184 LFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFE 243
           +F I   TG+I  T  +DRE    F +Y  A  + G   E PL L +K+ D NDNAP F 
Sbjct: 99  VFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFS 158

Query: 244 HRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDTGVI 303
             V   ++ EN  + T V K+ ATD DE + L++++ YKI+ Q P     F ++  TG +
Sbjct: 159 QSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEV 218

Query: 304 TTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEV 363
            T + FLDRE+   Y L++   D  G   GL +     I + D NDN P+  +TSY   +
Sbjct: 219 CTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASI 278

Query: 364 EENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLN 423
           EEN +  E++R++  D D   T +  A Y IL GN+   F I TDP TNEG+L VVK L+
Sbjct: 279 EENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLD 338

Query: 424 YEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDG 483
           YE    + L +GV N+A F  + +SQ   M  T V ++++D  EGP  HP       ++G
Sbjct: 339 YEQAPNIQLSIGVKNQADFHYSVASQF-QMHPTPVRIQVVDVREGPAFHPSTMAFSVREG 397

Query: 484 FPAGQELLG-----YKALDPEISS-GEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRES 537
              G  LL      Y A+D +  +    +RY    D  +W +I+  TG+++  +  D++S
Sbjct: 398 I-KGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKS 456

Query: 538 KFVKNNQYNISVVAV-DAVGRSCTGTLVVHLDDYNDHAPQIDKE-VTICQNNEDFAVLKP 595
           K++ N  Y   ++A+ D  G++ TGT+ + + D ND+ P I  E  TIC ++   +VL  
Sbjct: 457 KYIINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICIDSP--SVLIS 514

Query: 596 VDPDGPENGPPFQFFLDN---SASKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKDRH 652
           V+      G PF F + +     +  W++   +  +AIL  +Q L   +Y +PI +KD +
Sbjct: 515 VNEH--SYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPILVKDSY 572

Query: 653 GLVA--THMLTVRVCDCSTPSECRMKDKS---TRDVR--------------PNVILGRWA 693
                   M+ +  CDC     C     +   T D+                NV LG   
Sbjct: 573 NRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGPAG 632

Query: 694 ILAMVLGSVLLL---CILFTCFC 713
           I  MVLG +LL+    +L  C C
Sbjct: 633 IGMMVLGILLLILAPLLLLLCCC 655


>gi|116534898 desmoglein 2 preproprotein [Homo sapiens]
          Length = 1118

 Score =  298 bits (764), Expect = 1e-80
 Identities = 229/726 (31%), Positives = 348/726 (47%), Gaps = 37/726 (5%)

Query: 107 IKVVLSARENKS-PKKRHTKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQN 165
           ++V+ +  ENK  PK  H     L R KR W   P +L E         + +I SD A+ 
Sbjct: 26  LQVLSTRNENKLLPKHPH-----LVRQKRAWITAPVALREGEDLSKKNPIAKIHSDLAEE 80

Query: 166 --YTIFYSISGPGVDKEPFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPE 223
               I Y  +G G+ + PF +F   KDTG++  T  +DRE+   F L GYA  A G   E
Sbjct: 81  RGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSILDREETPFFLLTGYALDARGNNVE 140

Query: 224 YPLPLIIKIEDDNDNAPYFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKI 283
            PL L IK+ D NDN P F   V + +V E   + T V K+ ATD DEP+TL++++ Y+I
Sbjct: 141 KPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDADEPNTLNSKISYRI 200

Query: 284 LQQIPDHPKHFSIHPDTGVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGL-FNTGTITI 342
           +   P +P  F ++ DTG I TT+  LDRE+  +Y L +E RD  G+          + I
Sbjct: 201 VSLEPAYPPVFYLNKDTGEIYTTSVTLDREEHSSYTLTVEARDGNGEVTDKPVKQAQVQI 260

Query: 343 SLEDENDNPPSFTETSYVTEVEENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGN 402
            + D NDN P          VEEN+++VE+ R+KV D D   + +  A +    GNE G 
Sbjct: 261 RILDVNDNIPVVENKVLEGMVEENQVNVEVTRIKVFDADEIGSDNWLANFTFASGNEGGY 320

Query: 403 FIISTDPNTNEGVLCVVKPLNYEVNRQVILQVGVINEAQFSKAASSQ-TPTMCTTTVTVK 461
           F I TD  TNEG++ ++K ++YE  + +   V V N+A F K+  S+  PT     + VK
Sbjct: 321 FHIETDAQTNEGIVTLIKEVDYEEMKNLDFSVIVANKAAFHKSIRSKYKPT--PIPIKVK 378

Query: 462 IIDSDEGPECHPPV---KVIQSQDGFPAGQELLGYKALDPEISSGEGLRYQKLGDEDNWF 518
           + +  EG      V    V +S D    GQ +  ++A D +       RY KL D DNW 
Sbjct: 379 VKNVKEGIHFKSSVISIYVSESMDRSSKGQIIGNFQAFDEDTGLPAHARYVKLEDRDNWI 438

Query: 519 EINQHTGDLRTLKVLDRESKFVKNNQYNISVVAV--DAVGRSCTGTLVVHLDDYNDHAPQ 576
            ++  T +++  K+ D ES++V+N  Y + +VA+  D   ++ TGT++++++D ND+ P 
Sbjct: 439 SVDSVTSEIKLAKLPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLINVEDINDNCPT 498

Query: 577 IDKEV-TICQNNEDFAVLKPVDPDGPENGPPFQFFLDN---SASKNWNIEEKDGKTAILR 632
           + + V TIC + E +  +   D DG  N  PF F + +     ++ W I  ++  T++L 
Sbjct: 499 LIEPVQTICHDAE-YVNVTAEDLDGHPNSGPFSFSVIDKPPGMAEKWKIARQE-STSVLL 556

Query: 633 QRQNLDYNYYSVPIQIKDRHGLVA--THMLTVRVCDCSTPSECRMKDKSTRDVRPNVILG 690
           Q+         +   I D  G       +LT+ VC+C   S CR     +      V LG
Sbjct: 557 QQSEKKLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGCREAQHDS-----YVGLG 611

Query: 691 RWAILAMVLGSVLLLCI---LFTCFCVTAKRTVKKCFPEDIAQQNLIVSNTEGPGEEVTE 747
             AI  M+L  +LLL +   L  C C    +  K   P     + L   N EG   E   
Sbjct: 612 PAAIALMILAFLLLLLVPLLLLMCHC---GKGAKGFTPIPGTIEMLHPWNNEGAPPEDKV 668

Query: 748 ANIRLPMQTSNICDTSMSVGTVGGQG-IKTQQSFEMVKGGYTLDSNKGGGHQTLESVKGV 806
               LP+           VG +  +  +K   S  +VKG + +    G   +    + G 
Sbjct: 669 VPSFLPVDQGGSLVGRNGVGGMAKEATMKGSSSASIVKGQHEMSEMDGRWEEHRSLLSGR 728

Query: 807 GQGDTG 812
               TG
Sbjct: 729 ATQFTG 734


>gi|4826669 cadherin 15 preproprotein [Homo sapiens]
          Length = 814

 Score =  297 bits (760), Expect = 3e-80
 Identities = 216/638 (33%), Positives = 312/638 (48%), Gaps = 27/638 (4%)

Query: 128 ALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFNLFYI 187
           AL R +R W   P S+ EN     P  + QI+SD  Q  ++ YSI GPGVD+EP  +F I
Sbjct: 39  ALSRVRRAWVIPPISVSENHKR-LPYPLVQIKSDKQQLGSVIYSIQGPGVDEEPRGVFSI 97

Query: 188 EKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFEHRVT 247
           +K TG +F    +DREK ++F L  +A    G   E P  L I + D NDN P F     
Sbjct: 98  DKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQEAF 157

Query: 248 IFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDTGVITTTT 307
              V E    GT V +  ATD D+P+T +  L++ ILQQ    P+ FSI   TG I T  
Sbjct: 158 TGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQ--GSPELFSIDELTGEIRTVQ 215

Query: 308 PFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEENR 367
             LDRE    Y L ++V DM G   GL  T +  I+L+D NDN P FT   +  E  E  
Sbjct: 216 VGLDREVVAVYNLTLQVADMSGD--GLTATASAIITLDDINDNAPEFTRDEFFMEAIEAV 273

Query: 368 IDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYEVN 427
             V++ R++V+D+DLP +P+  A + IL+G+ +G F I TDP TNEGVL +VK L+YE  
Sbjct: 274 SGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESC 333

Query: 428 RQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPAG 487
               L+V V NEA    AA           V V + D++E P            +G P G
Sbjct: 334 EHYELKVSVQNEAPLQAAALRAERGQ--AKVRVHVQDTNEPPVFQENPLRTSLAEGAPPG 391

Query: 488 QELLGYKALDPEISSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNNQYNI 547
             +  + A DP+    + L Y K  D ++W +++  TG ++T  VL   S F+K   Y  
Sbjct: 392 TLVATFSARDPDTEQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYRA 451

Query: 548 SVVAVDAVG--RSCTGTLVVHLDDYNDHAPQI--DKEVTICQ--NNEDFAVLKPVDPDGP 601
            V+A D     R+ TGTL + + + NDHAP +      ++C   +     +L   D D P
Sbjct: 452 IVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGLLLGATDEDLP 511

Query: 602 ENGPPFQFFLD---NSASKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKD--RHGLVA 656
            +G PF F L        +NW++ + +   A LR R  +    + + + ++D  +     
Sbjct: 512 PHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRHQVPEGLHRLSLLLRDSGQPPQQR 571

Query: 657 THMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCILFTCFCVTA 716
              L V VC C     C     +       + LG    L +VL S LLL +L     + A
Sbjct: 572 EQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLG---ALVIVLASALLLLVLVLLVALRA 628

Query: 717 ---KRTVKKCF---PEDIAQQNLIVSNTEGPGEEVTEA 748
              K++  K     P+D  + N++  + +G GEE  +A
Sbjct: 629 RFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDA 666


>gi|29570800 cadherin-like 26 isoform a [Homo sapiens]
          Length = 832

 Score =  293 bits (750), Expect = 5e-79
 Identities = 204/662 (30%), Positives = 340/662 (51%), Gaps = 40/662 (6%)

Query: 106 EIKVVLSARENKSPKKRHTKDTA---LKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDA 162
           ++ ++ S ++      + TK+     L+RSKRRW      L E   GPFP+ + ++ ++ 
Sbjct: 23  QVSIIDSVQQETDDLTKQTKEKIYQPLRRSKRRWVITTLELEEEDPGPFPKLIGELFNNM 82

Query: 163 AQNYTIFYSISGPGVDKEP-FNLFYIEK-DTGDIFCTRSIDREKYEQFALY-GYATTADG 219
           + N ++ Y ISGPGVD+ P   LF +E  + G I+  R +DRE    F +Y      + G
Sbjct: 83  SYNMSLMYLISGPGVDEYPEIGLFSLEDHENGRIYVHRPVDREMTPSFTVYFDVVERSTG 142

Query: 220 YAPEYPLPLIIKIEDDNDNAPYFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRL 279
              +  L   I+I D ND+AP F  +    TV EN  +G  + ++ A DLDE +T ++++
Sbjct: 143 KIVDTSLIFNIRISDVNDHAPQFPEKEFNITVQENQSAGQPIFQMLAVDLDEENTPNSQV 202

Query: 280 KYKILQQIPDHPKH-FSIHPDTGVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTG 338
            Y ++ Q P   +  F +   +G I  +   LD E    + L++  RD G +P  L +T 
Sbjct: 203 LYFLISQTPLLKESGFRVDRLSGEIRLSG-CLDYETAPQFTLLIRARDCG-EP-SLSSTT 259

Query: 339 TITISLEDENDNPPSFTETSYVTEVEENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGN 398
           T+ + +++ N++ P+FT+ +Y  ++ E R    +LR+ VQD+D P T   +A + IL GN
Sbjct: 260 TVHVDVQEGNNHRPAFTQENYKVQIPEGRASQGVLRLLVQDRDSPFTSAWRAKFNILHGN 319

Query: 399 ENGNFIISTDPNTNEGVLCVVKPLNYEVNRQVILQVGVINEAQ--FSKAASSQTP--TMC 454
           E G+F ISTDP TNEG+L V+KPL+YE      L + V NE +  F +    Q P     
Sbjct: 320 EEGHFDISTDPETNEGILNVIKPLDYETRPAQSLIIVVENEERLVFCERGKLQPPRKAAA 379

Query: 455 TTTVTVKIIDSDEGPECHPPVKVIQSQDGFPAGQELLGYKALDPEISSGEGLRYQKLGDE 514
           + TV+V++ D+++ P  HP   ++  ++G   G  L  + A+DP+      +RY+ + D 
Sbjct: 380 SATVSVQVTDANDPPAFHPQSFIVNKEEGARPGTLLGTFNAMDPD----SQIRYELVHDP 435

Query: 515 DNWFEINQHTGDLRTLKVLDRESKFVKNNQYNISVVAVD--AVGRSCTGTLVVHLDDYND 572
            NW  +++++G + T++ +DRES  V N+ Y I + AVD     ++ TGTL++ L D ND
Sbjct: 436 ANWVSVDKNSGVVITVEPIDRESPHVNNSFYVIIIHAVDDGFPPQTATGTLMLFLSDIND 495

Query: 573 HAPQI---DKEVTICQNNEDFAVLKPV-----DPDGPENGPPFQFFLDN---SASKNWNI 621
           + P +    + + +C++    AV +P+     DPD      PF F LDN   +A   W +
Sbjct: 496 NVPTLRPRSRYMEVCES----AVHEPLHIEAEDPDLEPFSDPFTFELDNTWGNAEDTWKL 551

Query: 622 EEKDGKTAILRQRQNLDYNYYSVPIQIKDRHGLVATHMLTVRVCDCSTPSECRMKDKSTR 681
               G++  L   ++L    Y VP+ I D+ GL     + VR+C C++   C        
Sbjct: 552 GRNWGQSVELLTLRSLPRGNYLVPLFIGDKQGLSQKQTVHVRICPCASGLTC----VELA 607

Query: 682 DVRPNVILGR-WAILAMVLGSVLLLCILFTCFCVTAKRTVKKCFPEDIAQQNLIVSNTEG 740
           D    + +G  + + A  +   + L  L  C+ V   +        D   Q L++ N E 
Sbjct: 608 DAEVGLHVGALFPVCAAFVALAVALLFLLRCYFVLEPKRHGCSVSNDEGHQTLVMYNAES 667

Query: 741 PG 742
            G
Sbjct: 668 KG 669


>gi|119964718 desmoglein 3 preproprotein [Homo sapiens]
          Length = 999

 Score =  281 bits (720), Expect = 1e-75
 Identities = 217/727 (29%), Positives = 343/727 (47%), Gaps = 58/727 (7%)

Query: 124 TKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFN 183
           T   A +R KR W        E         + +I SD      I Y ISG G+D+ PF 
Sbjct: 39  TMQQAKRRQKREWVKFAKPCREGEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFG 98

Query: 184 LFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFE 243
           +F ++K+TGDI  T  +DRE+   F +   A  A G   E PL L +KI D NDN P F 
Sbjct: 99  IFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFS 158

Query: 244 HRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDTGVI 303
            ++ +  + EN  S + V  + ATD DEP+ L++++ +KI+ Q P     F +  +TG +
Sbjct: 159 QQIFMGEIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEV 218

Query: 304 TTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEV 363
            T T  LDRE+  +Y+L++   D  G+  GL       I ++D NDN P F ++ Y   +
Sbjct: 219 RTLTNSLDREQASSYRLVVSGADKDGE--GLSTQCECNIKVKDVNDNFPMFRDSQYSARI 276

Query: 364 EENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLN 423
           EEN +  E+LR +V D D   T +  AVY    GNE   F I TDP TNEG+L VVK L+
Sbjct: 277 EENILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALD 336

Query: 424 YEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDG 483
           YE  + V L + V N+A+F ++  S+     +T VT+++I+  EG    P  K    Q G
Sbjct: 337 YEQLQSVKLSIAVKNKAEFHQSVISRYRVQ-STPVTIQVINVREGIAFRPASKTFTVQKG 395

Query: 484 FPAGQ---ELLG-YKALDPEIS-SGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESK 538
             + +    +LG Y+A+D + + +   ++Y    ++  +  I+  T +++ +K ++R+S 
Sbjct: 396 ISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDST 455

Query: 539 FVKNNQYNISVVAVDA-VGRSCTGTLVVHLDDYNDHAPQIDKEVTICQNNEDFAVLKPVD 597
           F+ N      V+A+D   G++ TGT+ V + D+ND+ P    E     ++    V+    
Sbjct: 456 FIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSART 515

Query: 598 PDGPENGPPFQFFLDNSASK---NWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKD--RH 652
            +    G P+ F L++   K    W+I   +  +A+LR ++ +    Y + + + D   +
Sbjct: 516 LNNRYTG-PYTFALEDQPVKLPAVWSITTLNATSALLRAQEQIPPGVYHISLVLTDSQNN 574

Query: 653 GLVATHMLTVRVCDCSTPSECRMK----DKSTRDVRPNV-ILGRWAILAMVLGSVLLL-- 705
                  LT+ VC C     C          TR  RP+   LG  AI  ++LG +LLL  
Sbjct: 575 RCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAAIGLLLLGLLLLLLA 634

Query: 706 -CILFTCFC-------VTA--------------KRTVKKCFPEDIAQQNLIVSNTEGPGE 743
             +L TC C       VT               +  ++   PED    N+ V      G 
Sbjct: 635 PLLLLTCDCGAGSTGGVTGGFIPVPDGSEGTIHQWGIEGAHPEDKEITNICVPPVTANGA 694

Query: 744 EVTEANIRLPMQTSNICDTSMSVGTVGGQGIKTQQSFEM-VKGGYTLDSNKGGGHQTLES 802
           +         M++S +C  + + GT     ++     EM  K G   +S    G  T  +
Sbjct: 695 DF--------MESSEVCTNTYARGT----AVEGTSGMEMTTKLGAATESGGAAGFAT-GT 741

Query: 803 VKGVGQG 809
           V G   G
Sbjct: 742 VSGAASG 748


>gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens]
          Length = 785

 Score =  275 bits (703), Expect = 1e-73
 Identities = 220/657 (33%), Positives = 339/657 (51%), Gaps = 52/657 (7%)

Query: 131 RSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQ-NYTIFYSISGPGVDKEPFNLFYIEK 189
           R+KR W      ++E  +G  P +V ++ SD  + + +I Y +SG G      ++F I++
Sbjct: 44  RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGAS----SIFIIDE 99

Query: 190 DTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYP-LPLIIKIEDDNDNAPYFEHRVTI 248
           +TGDI  T+ +DRE+   + L   A       P  P    +IKI+D NDN P F      
Sbjct: 100 NTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYT 159

Query: 249 FTVPENCRSGTSVGKVTATDLDEPDTLHT-RLKYKILQQIPDHPKHFSIHPDTGVITTTT 307
             VPE    GTSV +VTATD D+P   ++ R+ Y ILQ  P    +FS+ P TGVI T  
Sbjct: 160 AGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQP----YFSVEPKTGVIKTAL 215

Query: 308 PFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEEN- 366
           P +DRE  D Y L+++ +DM GQ  GL  T ++T++L D NDNPP F   SY   V E+ 
Sbjct: 216 PNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESL 275

Query: 367 RIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYEV 426
            +   + R+K  D D+    +++  YKI+ G+  G F IS D  T EG++ + K L++E 
Sbjct: 276 PVASVVARIKAADADI--GANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEA 333

Query: 427 NRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPA 486
                L++   N+        S  P   TTTV + + D DE P    P+  ++  +    
Sbjct: 334 KTSYTLRIEAANK-DADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQV 392

Query: 487 GQELLGYKALDPEISSGEGLRY--QKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNNQ 544
           G  +    A DP+ SS   +RY   +  D + +F I+ ++G + T K LDRE+    N  
Sbjct: 393 GNIIGTVAAHDPD-SSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRET----NAI 447

Query: 545 YNISVVAVDA-----VGRSCTGTLVVHLDDYNDHAPQ--IDKEVTICQNNEDFAVLK--- 594
           +NI+V+A+++     VGR   G + + + D ND+AP+  +D E T+C+N +   V++   
Sbjct: 448 HNITVLAMESQNPSQVGR---GYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKIS 504

Query: 595 PVDPDGPENGPPFQFFLDNSASKNWNIEEKDGK--TAILRQRQN----LDYNYYSVPIQI 648
            VD D P NG  F F L   A+ N N   KD K  TA +  R+N     + + Y +PI I
Sbjct: 505 AVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFI 564

Query: 649 KD--RHGLVATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRW-AILAMVLGSVLLL 705
            D     L +T+ LT+RVCDC      +  +     +   +  G   AILA VL  ++L+
Sbjct: 565 VDSGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLI 624

Query: 706 CILFTCFCVTAKRTVKK--CFPED-IAQQNLIVSNTEGPGEEVTEANIRLPMQTSNI 759
            ++     VT +R  K+   F E+   ++N++  + EG GEE TEA     ++  N+
Sbjct: 625 LLI-----VTMRRRKKEPLIFDEERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNV 676


>gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens]
          Length = 785

 Score =  275 bits (703), Expect = 1e-73
 Identities = 220/657 (33%), Positives = 339/657 (51%), Gaps = 52/657 (7%)

Query: 131 RSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQ-NYTIFYSISGPGVDKEPFNLFYIEK 189
           R+KR W      ++E  +G  P +V ++ SD  + + +I Y +SG G      ++F I++
Sbjct: 44  RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGAS----SIFIIDE 99

Query: 190 DTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYP-LPLIIKIEDDNDNAPYFEHRVTI 248
           +TGDI  T+ +DRE+   + L   A       P  P    +IKI+D NDN P F      
Sbjct: 100 NTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYT 159

Query: 249 FTVPENCRSGTSVGKVTATDLDEPDTLHT-RLKYKILQQIPDHPKHFSIHPDTGVITTTT 307
             VPE    GTSV +VTATD D+P   ++ R+ Y ILQ  P    +FS+ P TGVI T  
Sbjct: 160 AGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQP----YFSVEPKTGVIKTAL 215

Query: 308 PFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEEN- 366
           P +DRE  D Y L+++ +DM GQ  GL  T ++T++L D NDNPP F   SY   V E+ 
Sbjct: 216 PNMDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESL 275

Query: 367 RIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYEV 426
            +   + R+K  D D+    +++  YKI+ G+  G F IS D  T EG++ + K L++E 
Sbjct: 276 PVASVVARIKAADADI--GANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEA 333

Query: 427 NRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPA 486
                L++   N+        S  P   TTTV + + D DE P    P+  ++  +    
Sbjct: 334 KTSYTLRIEAANK-DADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQV 392

Query: 487 GQELLGYKALDPEISSGEGLRY--QKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNNQ 544
           G  +    A DP+ SS   +RY   +  D + +F I+ ++G + T K LDRE+    N  
Sbjct: 393 GNIIGTVAAHDPD-SSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRET----NAI 447

Query: 545 YNISVVAVDA-----VGRSCTGTLVVHLDDYNDHAPQ--IDKEVTICQNNEDFAVLK--- 594
           +NI+V+A+++     VGR   G + + + D ND+AP+  +D E T+C+N +   V++   
Sbjct: 448 HNITVLAMESQNPSQVGR---GYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKIS 504

Query: 595 PVDPDGPENGPPFQFFLDNSASKNWNIEEKDGK--TAILRQRQN----LDYNYYSVPIQI 648
            VD D P NG  F F L   A+ N N   KD K  TA +  R+N     + + Y +PI I
Sbjct: 505 AVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFI 564

Query: 649 KD--RHGLVATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRW-AILAMVLGSVLLL 705
            D     L +T+ LT+RVCDC      +  +     +   +  G   AILA VL  ++L+
Sbjct: 565 VDSGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLI 624

Query: 706 CILFTCFCVTAKRTVKK--CFPED-IAQQNLIVSNTEGPGEEVTEANIRLPMQTSNI 759
            ++     VT +R  K+   F E+   ++N++  + EG GEE TEA     ++  N+
Sbjct: 625 LLI-----VTMRRRKKEPLIFDEERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNV 676


>gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens]
          Length = 790

 Score =  270 bits (691), Expect = 3e-72
 Identities = 205/639 (32%), Positives = 324/639 (50%), Gaps = 39/639 (6%)

Query: 131 RSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQ-NYTIFYSISGPGVDKEPFNLFYIEK 189
           R KR W      ++E  +GP PQ+V ++ S++ + + ++ Y ++G G       +F I+ 
Sbjct: 50  RPKRGWVWNQFFVLEEHMGPDPQYVGKLHSNSDKGDGSVKYILTGEGAG----TIFIIDD 105

Query: 190 DTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYP-LPLIIKIEDDNDNAPYFEHRVTI 248
            TGDI  T+S+DRE+   + L+  A       P  P    IIK++D NDNAP F     I
Sbjct: 106 TTGDIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFTDGPYI 165

Query: 249 FTVPENCRSGTSVGKVTATDLDEPDTLHT-RLKYKILQQIPDHPKHFSIHPDTGVITTTT 307
            TVPE    GTSV +VTATD D+P   ++ R+ Y ILQ  P    +FS+ P TGVI T  
Sbjct: 166 VTVPEMSDMGTSVLQVTATDADDPTYGNSARVVYSILQGQP----YFSVDPKTGVIRTAL 221

Query: 308 PFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEEN- 366
             +DRE  + Y ++++ +DM GQ  GL  + T+ I+L D NDNPP F +  Y   V E+ 
Sbjct: 222 HNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPESA 281

Query: 367 RIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYEV 426
           ++   + ++K  D D  +  ++   Y I+ G+  G F ISTD  T EG+L + KPLNYE 
Sbjct: 282 QVGSAVGKIKANDADTGS--NADMTYSIINGDGMGIFSISTDKETREGILSLKKPLNYEK 339

Query: 427 NRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPA 486
            +   L +   N        S   P    T + + + D DE P    P  +++  +    
Sbjct: 340 KKSYTLNIEGAN-THLDFRFSHLGPFKDATMLKIIVGDVDEPPLFSMPSYLMEVYENAKI 398

Query: 487 GQELLGYKALDPEISSGEGLRY--QKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNNQ 544
           G  +    A DP+ S+   +RY      ++D +F I+ +TG +RT KVLDRE    +   
Sbjct: 399 GTVVGTVLAQDPD-STNSLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDRE----ETPW 453

Query: 545 YNISVVA--VDAVGRSCTGTLVVHLDDYNDHAPQIDKE--VTICQNNEDFAVLKPV---D 597
           YNI+V A  +D        T+ + + D ND+ P++ +E  + +C+N++   V+  +   D
Sbjct: 454 YNITVTASEIDNPDLLSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTISATD 513

Query: 598 PDGPENGPPFQFFLDNSASKNWNI---EEKDGKTAILRQRQNLD---YNYYSVPIQIKDR 651
            D   NGP F FFLD     N N    + +D   +IL +R+       + Y +PI I D 
Sbjct: 514 KDDFANGPRFNFFLDERLPVNPNFTLKDNEDNTASILTRRRRFSRTVQDVYYLPIMISDG 573

Query: 652 --HGLVATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCILF 709
               L ++  LT+RVC C    + R++         +  L   A++A++L  ++LL I+ 
Sbjct: 574 GIPSLSSSSTLTIRVCACE--RDGRVRTCHAEAFLSSAGLSTGALIAILLCVLILLAIVV 631

Query: 710 TCFCVTAKRTVKKCFPEDIAQQNLIVSNTEGPGEEVTEA 748
               +   +       E+  ++N++  + EG GEE TEA
Sbjct: 632 LFITLRRSKKEPLIISEEDVRENVVTYDDEGGGEEDTEA 670


>gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens]
          Length = 796

 Score =  259 bits (661), Expect = 9e-69
 Identities = 205/652 (31%), Positives = 315/652 (48%), Gaps = 56/652 (8%)

Query: 129 LKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDA-AQNYTIFYSISGPGVDKEPFNLFYI 187
           L+RSKR W      ++E   GP P  V ++ SD  + +  I Y +SG G       +F I
Sbjct: 48  LQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAG----TIFVI 103

Query: 188 EKDTGDIFCTRSIDREKYEQFALYGYATTADGYAP-EYPLPLIIKIEDDNDNAPYFEHRV 246
           +  +G+I  T+++DRE+  Q+ L   A   D   P E P   I+K++D NDN P F H  
Sbjct: 104 DDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHET 163

Query: 247 TIFTVPENCRSGTSVGKVTATDLDEPDTLHT-RLKYKILQQIPDHPKHFSIHPDTGVITT 305
               VPE    GTSV +VTA+D D+P   ++ +L Y IL+  P    +FS+   TG+I T
Sbjct: 164 YHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQP----YFSVEAQTGIIRT 219

Query: 306 TTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEE 365
             P +DRE  + Y ++++ +DMGG   GL  T  +TI+L D NDNPP F ++ Y   V E
Sbjct: 220 ALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSE 279

Query: 366 NRI-DVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNY 424
             +   E+ R+K +D D+    +    Y I+ G+   +F I+TD  T EGV+ + KP+++
Sbjct: 280 AAVPGEEVGRVKAKDPDIGE--NGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDF 337

Query: 425 EVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGF 484
           E  R   L+V   N         S  P   T TV + + D+DE P    P  + + Q+  
Sbjct: 338 ETKRAYSLKVEAAN-VHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENA 396

Query: 485 PAGQELLGYKALDPEISSGEGLRY--QKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKN 542
            AG  +    A DP+ ++   +RY   +  D D +F IN   G ++T K LDRE    + 
Sbjct: 397 AAGTVVGRVHAKDPD-AANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDRE----ET 451

Query: 543 NQYNISVVAVDAVGR--SCTGTLVVHLDDYNDHAPQI--DKEVTICQ-------NNEDFA 591
              NI+V A +   R       + + + D ND+AP+     E  IC+       +N+   
Sbjct: 452 AWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIV 511

Query: 592 VLKPVDPDGPENGPPFQFFLDNSASKNWNIEEKDGKT----------AILRQRQNLDYNY 641
            +   D D   NGP F F L      N N   +D +              RQ+Q+L    
Sbjct: 512 TISADDKDDTANGPRFIFSLPPEIIHNPNFTVRDNRDNTAGVYARRGGFSRQKQDL---- 567

Query: 642 YSVPIQIKDR--HGLVATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVL 699
           Y +PI I D     + +T+ LT++VC C         +     +   +  G    L  +L
Sbjct: 568 YLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTG---ALIAIL 624

Query: 700 GSVLLLCILFTCFCVTAKRTVKK---CFPEDIAQQNLIVSNTEGPGEEVTEA 748
             +++L ++   F VT +R  K+    F E+  ++N+I  + EG GEE TEA
Sbjct: 625 ACIVILLVIVVLF-VTLRRQKKEPLIVFEEEDVRENIITYDDEGGGEEDTEA 675


>gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens]
          Length = 788

 Score =  252 bits (643), Expect = 1e-66
 Identities = 212/659 (32%), Positives = 322/659 (48%), Gaps = 45/659 (6%)

Query: 110 VLSARENKSPKKRHTKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQ-NYTI 168
           +LS+R  +S  K       L R KR W      L+E   G   Q+V ++ SD  + + ++
Sbjct: 36  ILSSRVPRSDGK------ILHRQKRGWMWNQFFLLEEYTGSDYQYVGKLHSDQDKGDGSL 89

Query: 169 FYSISGPGVDKEPFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYP-LP 227
            Y +SG G       LF I++ TGDI  TR IDRE+   + L   A       P  P   
Sbjct: 90  KYILSGDGAG----TLFIIDEKTGDIHATRRIDREEKAFYTLRAQAINRRTLRPVEPESE 145

Query: 228 LIIKIEDDNDNAPYFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHT-RLKYKILQQ 286
            +IKI D NDN P F   +   +VPE    GTSV +VTATD D+P   ++ R+ Y ILQ 
Sbjct: 146 FVIKIHDINDNEPTFPEEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSILQG 205

Query: 287 IPDHPKHFSIHPDTGVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLED 346
            P    +FS+ P+TG+I T  P ++RE  + YQ++++ +DMGGQ  GL  T T+ I+L D
Sbjct: 206 QP----YFSVEPETGIIRTALPNMNRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTD 261

Query: 347 ENDNPPSFTE-TSYVTEVEENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFII 405
            NDNPP F + T ++  +E + +   I  +K  D D     +++  Y+I+ G+    F I
Sbjct: 262 VNDNPPRFPQNTIHLRVLESSPVGTAIGSVKATDAD--TGKNAEVEYRIIDGDGTDMFDI 319

Query: 406 STDPNTNEGVLCVVKPLNYEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDS 465
            T+ +T EG++ V KPL+YE  R   L+V   N            P   TT V + I D 
Sbjct: 320 VTEKDTQEGIITVKKPLDYESRRLYTLKVEAEN-THVDPRFYYLGPFKDTTIVKISIEDV 378

Query: 466 DEGPECHPPVKVIQSQDGFPAGQELLGYKALDPE-ISSGEGLRYQKLGDEDNWFEINQHT 524
           DE P       + +  +    G  +    A DP+ ISS       +  D D  F I+   
Sbjct: 379 DEPPVFSRSSYLFEVHEDIEVGTIIGTVMARDPDSISSPIRFSLDRHTDLDRIFNIHSGN 438

Query: 525 GDLRTLKVLDRESKFVKNNQYNISVVAVDAVGRSCTG--TLVVHLDDYNDHAPQ--IDKE 580
           G L T K LDRE     +  +N++V+A +      T    + V + D ND+APQ  +  +
Sbjct: 439 GSLYTSKPLDRE----LSQWHNLTVIAAEINNPKETTRVAVFVRILDVNDNAPQFAVFYD 494

Query: 581 VTICQN---NEDFAVLKPVDPDGPENGPPFQFFLDNSASKNWNIEEKDGKTAILRQRQN- 636
             +C+N    +    +  VD D P  G  F FF   + + N+ +++ +  TA +  R+N 
Sbjct: 495 TFVCENARPGQLIQTISAVDKDDPLGGQKF-FFSLAAVNPNFTVQDNEDNTARILTRKNG 553

Query: 637 ---LDYNYYSVPIQIKDRHGLV--ATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGR 691
               + + Y +P+ I D    +  +T  LT+RVC C   S+  M+  S   +     L  
Sbjct: 554 FNRHEISTYLLPVVISDNDYPIQSSTGTLTIRVCACD--SQGNMQSCSAEALLLPAGLST 611

Query: 692 WAILAMVLGSVLLLCI--LFTCFCVTAKRTVKKCFPEDIAQQNLIVSNTEGPGEEVTEA 748
            A++A++L  ++LL I  LF       K+       EDI + N++  N EG GEE T+A
Sbjct: 612 GALIAILLCIIILLVIVVLFAALKRQRKKEPLILSKEDI-RDNIVSYNDEGGGEEDTQA 669


>gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens]
          Length = 801

 Score =  246 bits (627), Expect = 8e-65
 Identities = 206/650 (31%), Positives = 323/650 (49%), Gaps = 48/650 (7%)

Query: 125 KDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQ-NYTIFYSISGPGVDKEPFN 183
           K  + +R+KR W      ++E   G  P +V ++ SD  + + +I Y +SG G       
Sbjct: 50  KPQSHQRTKRSWVWNQFFVLEEYTGTDPLYVGKLHSDMDRGDGSIKYILSGEGAGI---- 105

Query: 184 LFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYP-LPLIIKIEDDNDNAPYF 242
           +F I+  TGDI   + +DRE+  Q+ L   A       P  P    IIKI+D NDN P F
Sbjct: 106 VFTIDDTTGDIHAIQRLDREERAQYTLRAQALDRRTGRPMEPESEFIIKIQDINDNEPKF 165

Query: 243 EHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHT-RLKYKILQQIPDHPKHFSIHPDTG 301
                + TVPE    GTSV +VTATD D+P   ++ R+ Y ILQ  P    +FS+   TG
Sbjct: 166 LDGPYVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSILQGQP----YFSVDSKTG 221

Query: 302 VITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVT 361
           VI T    +DRE  + Y++I++ +DMGGQ  GL  T T+ I+L D NDNPP F +  Y  
Sbjct: 222 VIRTALMNMDREAKEYYEVIIQAKDMGGQLGGLAGTTTVNITLSDVNDNPPRFPQKHYQM 281

Query: 362 EVEENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKP 421
            V E+   +     +V  +DL    +++  Y I+ G+    F ISTDPN   G++ V KP
Sbjct: 282 SVLES-APISSTVGRVFAKDLDEGINAEMKYTIVDGDGADAFDISTDPNFQVGIITVKKP 340

Query: 422 LNYEVNRQVILQVGVIN---EAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVI 478
           L++E  +   L+V   N   E +F        P   TTTV + + D DE P   P    +
Sbjct: 341 LSFESKKSYTLKVEGANPHLEMRFLNLG----PFQDTTTVHISVEDVDEPPVFEPGFYFV 396

Query: 479 QSQDGFPAGQELLGYKALDPEISSGEGLRY--QKLGDEDNWFEINQHTGDLRTLKVLDRE 536
           +  +    G  +    A DP++++   +RY   +  D   +F ++  TG L T + LDRE
Sbjct: 397 EVPEDVAIGTTIQIISAKDPDVTN-NSIRYSIDRSSDPGRFFYVDITTGALMTARPLDRE 455

Query: 537 SKFVKNNQYNISVVAVDAVGRSCTGTLVVHLD--DYNDHAPQIDK--EVTICQN---NED 589
               + + +NI+V+A++    S  G++ V +   D ND+AP+  +  E  +C+N    + 
Sbjct: 456 ----EFSWHNITVLAMEMNNPSQVGSVPVTIKVLDVNDNAPEFPRFYEAFVCENAKAGQL 511

Query: 590 FAVLKPVDPDGPENGPPFQFFLDNSASKNWNI---EEKDGKTAILRQRQNL---DYNYYS 643
              +  VD D P NG  F + L   A+ N N    + +D    IL +R      + + + 
Sbjct: 512 IQTVSAVDQDDPRNGQHFYYSLAPEAANNPNFTIRDNQDNTARILTRRSGFRQQEQSVFH 571

Query: 644 VPIQIKD--RHGLVATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGS 701
           +PI I D  +  L +T  LT++VC C    +  +   S       V L R A++A +L  
Sbjct: 572 LPILIADSGQPVLSSTGTLTIQVCSCD--DDGHVMSCSPEAYMLPVSLSRGALIA-ILAC 628

Query: 702 VLLLCILFTCFCVTAKRTVKKCF---PEDIAQQNLIVSNTEGPGEEVTEA 748
           + +L +L     ++ +R  K+ +    E+   +N++  + EG GEE TEA
Sbjct: 629 IFVLLVL-VLLILSMRRHRKQPYIIDDEENIHENIVRYDDEGGGEEDTEA 677


>gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens]
          Length = 794

 Score =  245 bits (626), Expect = 1e-64
 Identities = 202/642 (31%), Positives = 317/642 (49%), Gaps = 42/642 (6%)

Query: 130 KRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNY-TIFYSISGPGVDKEPFNLFYIE 188
           +R KR W      ++E  +G  PQ+V ++ SD  +   T+ Y++SG G       +F I+
Sbjct: 50  QRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAG----TVFTID 105

Query: 189 KDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYP-LPLIIKIEDDNDNAPYFEHRVT 247
           + TGDI   RS+DRE+   + L   A   +   P  P    IIK++D NDN P F     
Sbjct: 106 ETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPY 165

Query: 248 IFTVPENCRSGTSVGKVTATDLDEPDTLHT-RLKYKILQQIPDHPKHFSIHPDTGVITTT 306
           + TVPE    G  V +V ATD D+P   ++ R+ Y ILQ  P    +FSI P TGVI T 
Sbjct: 166 VATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQP----YFSIDPKTGVIRTA 221

Query: 307 TPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEV-EE 365
            P +DRE  + YQ++++ +DMGGQ  GL  T  + I+L D NDNPP F ++ +  +V E 
Sbjct: 222 LPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPES 281

Query: 366 NRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYE 425
           + I   I R++  D D     +++  Y I+ G+    F I TD +T EGV+ + KPL++E
Sbjct: 282 SPIGSAIGRIRAVDPDFGQ--NAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFE 339

Query: 426 VNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFP 485
             +    +V   N         S  P   T TV + ++D DE P    P+  ++  +  P
Sbjct: 340 TKKAYTFKVEASN-LHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTP 398

Query: 486 AGQELLGYKALDPEISSGEGLRY--QKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNN 543
            G  +    A D ++ S   +RY      D D++F I+ + G + T ++LDRES      
Sbjct: 399 VGTIIGAVTAQDLDVGS-SAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRES----TA 453

Query: 544 QYNISVVAVDAVGRSCTG--TLVVHLDDYNDHAPQID--KEVTICQN---NEDFAVLKPV 596
           QYN S++A        T    +++++ D N+  P+I    E  +C+N    +   ++   
Sbjct: 454 QYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQIVSAA 513

Query: 597 DPDGPENGPPFQFFLDNSAS--KNWNIEEKDGKTAILRQRQN----LDYNYYSVPIQIKD 650
           D D    G  F F L   A+   N+ + +    TA +  R+N         Y +P+ I+D
Sbjct: 514 DRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFLPVVIED 573

Query: 651 RHGLV--ATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCI- 707
               V  +T+ +T+RVC C   S+  +   +   +   V L   A++A++L  V+LL I 
Sbjct: 574 SSYPVQSSTNTMTIRVCRCD--SDGTILSCNVEAIFLPVGLSTGALIAILLCIVILLAIV 631

Query: 708 -LFTCFCVTAKRTVKKCFPEDIAQQNLIVSNTEGPGEEVTEA 748
            L+       K+       EDI + N+I  + EG GEE T+A
Sbjct: 632 VLYVALRRQKKKDTLMTSKEDI-RDNVIHYDDEGGGEEDTQA 672


>gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens]
          Length = 799

 Score =  245 bits (626), Expect = 1e-64
 Identities = 199/644 (30%), Positives = 311/644 (48%), Gaps = 44/644 (6%)

Query: 129 LKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQ-NYTIFYSISGPGVDKEPFNLFYI 187
           L RSKR W      ++E   GP P  V ++ +D    +  I Y +SG G       +F I
Sbjct: 56  LNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAG----TIFQI 111

Query: 188 EKDTGDIFCTRSIDREKYEQFALYGYATTADGYAP-EYPLPLIIKIEDDNDNAPYFEHRV 246
              TGDI   + +DRE+  ++ L   A   +   P E P   IIK++D NDNAP F +  
Sbjct: 112 NDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGP 171

Query: 247 TIFTVPENCRSGTSVGKVTATDLDEPDTLHT-RLKYKILQQIPDHPKHFSIHPDTGVITT 305
              TVPE    GTSV  VTATD D+P   ++ +L Y IL+  P    +FSI P+T +I T
Sbjct: 172 YHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQP----YFSIEPETAIIKT 227

Query: 306 TTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEE 365
             P +DRE  + Y ++++ +DMGG   GL  T T+T++L D NDNPP F ++ Y   V E
Sbjct: 228 ALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPE 287

Query: 366 NRI-DVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNY 424
           + +    I R+K  DQD+     S   Y I+ G+    F I++D    +G++ + KPL++
Sbjct: 288 DVVLGTAIGRVKANDQDIGENAQSS--YDIIDGDGTALFEITSDAQAQDGIIRLRKPLDF 345

Query: 425 EVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGF 484
           E  +   L+V   N        S + P   T TV + + D+DE P    P  +++  +  
Sbjct: 346 ETKKSYTLKVEAAN-VHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENA 404

Query: 485 PAGQELLGYKALDPEISSGEGLRY--QKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKN 542
                +    A DP+I+S   +R+   +  D +  F IN   G +     LDRE      
Sbjct: 405 ALNSVIGQVTARDPDITSSP-IRFSIDRHTDLERQFNINADDGKITLATPLDRELSV--- 460

Query: 543 NQYNISVVAVDAVGRSCTGTLVVHLD--DYNDHAPQI--DKEVTICQNNEDFAVLKPV-- 596
             +NI+++A +    S    + V +   D ND+AP+   + E  +C+N +   V++ V  
Sbjct: 461 -WHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSA 519

Query: 597 -DPDGPENGPPFQFFLDNSASKNWNI---EEKDGKTAILRQRQNLD---YNYYSVPIQIK 649
            D D P+NG  F + L      N N    + +D   +IL +    +      Y +PI I 
Sbjct: 520 MDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIIS 579

Query: 650 DRHG--LVATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCI 707
           D     L +T  LT+RVC CS     +  +     +   + +G    L  +L  ++LL +
Sbjct: 580 DSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMG---ALIAILACIILLLV 636

Query: 708 LFTCFCVTAKRTVKKCF---PEDIAQQNLIVSNTEGPGEEVTEA 748
           +   F VT +R   +      ++  ++N+I  + EG GEE TEA
Sbjct: 637 IVVLF-VTLRRHKNEPLIIKDDEDVRENIIRYDDEGGGEEDTEA 679


>gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens]
          Length = 790

 Score =  231 bits (590), Expect = 2e-60
 Identities = 207/670 (30%), Positives = 325/670 (48%), Gaps = 54/670 (8%)

Query: 111 LSARENKSPKKRHTKDTA------LKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQ 164
           LS R +  P K+   + +      L RSKR W      L+E   G   Q+V ++ SD  +
Sbjct: 24  LSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDR 83

Query: 165 -NYTIFYSISGPGVDKEPFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPE 223
            + ++ Y +SG G      +LF I ++TGDI  T+ +DRE+   + L   A       P 
Sbjct: 84  GDGSLKYILSGDGAG----DLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPV 139

Query: 224 YP-LPLIIKIEDDNDNAPYFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHT-RLKY 281
            P    IIKI D NDN P F   V   TVPE    GT V +VTATD D+P   ++ ++ Y
Sbjct: 140 EPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVY 199

Query: 282 KILQQIPDHPKHFSIHPDTGVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTIT 341
            ILQ  P    +FS+  +TG+I T    +DRE  + YQ++++ +DMGGQ  GL  T T+ 
Sbjct: 200 SILQGQP----YFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVN 255

Query: 342 ISLEDENDNPPSFTETSYVTEV-EENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNEN 400
           I+L D NDNPP F +++Y  +  E +     I R+K  D D+    +++  Y I  G   
Sbjct: 256 ITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGE--NAEIEYSITDGEGL 313

Query: 401 GNFIISTDPNTNEGVLCVVKPLNYEVNRQVILQVGVIN---EAQFSKAASSQTPTMCTTT 457
             F + TD  T EG++ V K L++E  +   L+V   N   E +F        P   + T
Sbjct: 314 DMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLG----PFKDSAT 369

Query: 458 VTVKIIDSDEGPECHPPVKVIQSQDGFPAGQELLGYKALDPEISSGEGLRY--QKLGDED 515
           V + + D DE P       ++Q ++       +    A DP+ ++   ++Y   +  D D
Sbjct: 370 VRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPD-AARNPVKYSVDRHTDMD 428

Query: 516 NWFEINQHTGDLRTLKVLDRESKFVKNNQYNISVVA--VDAVGRSCTGTLVVHLDDYNDH 573
             F I+   G + T K+LDRE+       +NI+V+A  ++   +S    L + + D ND+
Sbjct: 429 RIFNIDSGNGSIFTSKLLDRETLL----WHNITVIATEINNPKQSSRVPLYIKVLDVNDN 484

Query: 574 APQIDK--EVTICQN---NEDFAVLKPVDPDGPENGPPFQFFL--DNSASKNWNIEEKDG 626
           AP+  +  E  +C+    ++    L  VD D P +G  F F L  + ++  N+ I++   
Sbjct: 485 APEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKD 544

Query: 627 KTAILRQRQN----LDYNYYSVPIQIKDRHGLV--ATHMLTVRVCDCSTPSECRMKDKST 680
            TA +  R+N     + + Y +P+ I D    V  +T  +TVRVC C       M+    
Sbjct: 545 NTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACD--HHGNMQSCHA 602

Query: 681 RDVRPNVILGRWAILAMVLGSVLLL--CILFTCFCVTAKRTVKKCFPEDIAQQNLIVSNT 738
             +     L   A++A++L  V+LL   +LF       K+       EDI + N++  N 
Sbjct: 603 EALIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIISKEDI-RDNIVSYND 661

Query: 739 EGPGEEVTEA 748
           EG GEE T+A
Sbjct: 662 EGGGEEDTQA 671


>gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens]
          Length = 789

 Score =  227 bits (578), Expect = 4e-59
 Identities = 196/653 (30%), Positives = 320/653 (49%), Gaps = 50/653 (7%)

Query: 124 TKDTA--LKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQ-NYTIFYSISGPGVDKE 180
           TKD    L+R+KR W      L+E   G   Q+V ++ +D  + +  + Y ++G G    
Sbjct: 41  TKDDGKMLRRTKRGWMWNQFFLLEEYTGTDTQYVGKLHTDQDKGDGNLKYILTGDGAG-- 98

Query: 181 PFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTAD-GYAPEYPLPLIIKIEDDNDNA 239
             +LF I+++TGDI   + +DRE+   + L   A     G   E     IIKI D NDN 
Sbjct: 99  --SLFVIDENTGDIHAAKKLDREEKSLYILRAKAIDRKTGRQVEPESEFIIKIHDINDNE 156

Query: 240 PYFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHT-RLKYKILQQIPDHPKHFSIHP 298
           P F   +   +VPE    GTSV +VTATD D+ +  ++ ++ Y ILQ  P    +FS+ P
Sbjct: 157 PKFTKDLYTASVPEMSGVGTSVIQVTATDADDANYGNSAKVVYSILQGQP----YFSVDP 212

Query: 299 DTGVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETS 358
           ++G+I T  P + RE  + YQ++++ +DMGGQ  GL  T T+ I+L D N+NPP F +++
Sbjct: 213 ESGIIKTALPDMSRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNNNPPRFPQST 272

Query: 359 Y-VTEVEENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLC 417
           Y     E   +   + R+K  D D+    +++  Y I +G+    F + TD +T EG++ 
Sbjct: 273 YQFNSPESVPLGTHLGRIKANDPDVGE--NAEMEYSIAEGDGADMFDVITDKDTQEGIIT 330

Query: 418 VVKPLNYEVNRQVILQVGVIN---EAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPP 474
           V + L++E      L+V   N   + +F        P   T  V + + D DE P     
Sbjct: 331 VKQNLDFENQMLYTLRVDASNTHPDPRFLHLG----PFKDTAVVKISVEDIDEPPVFTKV 386

Query: 475 VKVIQSQDGFPAGQELLGYKALDPEISSGEGLRY--QKLGDEDNWFEINQHTGDLRTLKV 532
             +I+  +    G  +    A DP+ +    ++Y   +  D D  F I+   G + TLK 
Sbjct: 387 SYLIEVDEDVKEGSIIGQVTAYDPD-ARNNLIKYSVDRHTDMDRIFGIHSENGSIFTLKA 445

Query: 533 LDRESKFVKNNQYNISVVA--VDAVGRSCTGTLVVHLDDYNDHAPQIDK--EVTICQNNE 588
           LDRES    +  +NI+V A  ++   +S    + + + D NDHAP+     E  +C+N +
Sbjct: 446 LDRES----SPWHNITVTATEINNPKQSSHIPVFIRILDINDHAPEFAMYYETFVCENAK 501

Query: 589 DFAVLKPV---DPDGPENGPPFQFFLDNSASKNWN---IEEKDGKTAILRQRQNLDYN-- 640
              +++ V   D D P  G  F F      + N N   ++ KD    I+ ++     N  
Sbjct: 502 PGQLIQTVSVMDKDDPPRGHKFFFEPVPEFTLNPNFTIVDNKDNTAGIMTRKDGYSRNKM 561

Query: 641 -YYSVPIQIKDRHGLV--ATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAM 697
             Y +PI I D    +  +T  LT+RVC C   ++  M+  +   +  +  L   A++A+
Sbjct: 562 STYLLPILIFDNDYPIQSSTGTLTIRVCACD--NQGNMQSCTAEALILSAGLSTGALVAI 619

Query: 698 VLGSVLLLCILFTCFCVTAKRTVKK--CFPEDIAQQNLIVSNTEGPGEEVTEA 748
           +L  VL+L IL   F    ++  K+     +D  + N++  N EG GEE T+A
Sbjct: 620 LL-CVLILLILVVLFAALKRQRKKEPLIISKDDVRDNIVTYNDEGGGEEDTQA 671


>gi|32880203 cadherin-like 24 isoform 2 [Homo sapiens]
          Length = 781

 Score =  218 bits (556), Expect = 1e-56
 Identities = 190/646 (29%), Positives = 307/646 (47%), Gaps = 49/646 (7%)

Query: 128 ALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNY-TIFYSISGPGVDKEPFNLFY 186
           AL R++R W      ++E   GP P  + ++ SD  +      Y ++G G       +F 
Sbjct: 38  ALLRTRRSWVWNQFFVIEEYAGPEPVLIGKLHSDVDRGEGRTKYLLTGEGAG----TVFV 93

Query: 187 IEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAP-EYPLPLIIKIEDDNDNAPYFEHR 245
           I++ TG+I  T+S+DRE+  Q+ L   A       P E P   IIK++D NDN P F   
Sbjct: 94  IDEATGNIHVTKSLDREEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPIFPLG 153

Query: 246 VTIFTVPENCRSGTSVGKVTATDLDEPDTLHT-RLKYKILQQIPDHPKHFSIHPDTGVIT 304
               TVPE    GTSV +VTA D D+P   ++ +L Y +L  +P     FS+ P TGV+ 
Sbjct: 154 PYHATVPEMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLDGLP----FFSVDPQTGVVR 209

Query: 305 TTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVE 364
           T  P +DRE  + + ++++ +DMGG   GL  + T+T++L D NDNPP F ++ Y   V 
Sbjct: 210 TAIPNMDRETQEEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVNDNPPKFPQSLYQFSVV 269

Query: 365 ENRIDVEIL-RMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLN 423
           E      ++ R++ QD DL +  ++   Y IL G  +  F ISTD    +G+L V KPL+
Sbjct: 270 ETAGPGTLVGRLRAQDPDLGD--NALMAYSILDGEGSEAFSISTDLQGRDGLLTVRKPLD 327

Query: 424 YEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDG 483
           +E  R    +V   N      A   + P     +V V + D+ E P        +   + 
Sbjct: 328 FESQRSYSFRVEATN-TLIDPAYLRRGPFKDVASVRVAVQDAPEPPAFTQAAYHLTVPEN 386

Query: 484 FPAGQELLGYKALDPEISSGEGLRYQKL--GDEDNWFEINQHTGDLRTLKVLDRESKFVK 541
              G  +    A D + S    +RY  L   D +  F I    G + T   LDRE++   
Sbjct: 387 KAPGTLVGQISAADLD-SPASPIRYSILPHSDPERCFSIQPEEGTIHTAAPLDREAR--- 442

Query: 542 NNQYNISVVA--VDAVGRSCTGTLVVHLDDYNDHAPQIDK--EVTICQN---NEDFAVLK 594
              +N++V+A  +D+  ++    + +   D ND+APQ+ +  +  +C +    +   V++
Sbjct: 443 -AWHNLTVLATELDSSAQASRVQVAIQTLDENDNAPQLAEPYDTFVCDSAAPGQLIQVIR 501

Query: 595 PVDPDGPENGPPFQFFLDNSASKNWNIEE-KDGKTAILRQRQNLDYNY--YSVPIQIKD- 650
            +D D   N     F        N+ +++ +DG  ++L   +     +  Y VPI++ D 
Sbjct: 502 ALDRDEVGNSSHVSFQGPLGPDANFTVQDNRDGSASLLLPSRPAPPRHAPYLVPIELWDW 561

Query: 651 -RHGLVATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVI-----LGRWAILAMV--LGSV 702
            +  L +T  +TV VC C         D S     P        L   A+LA++  +G++
Sbjct: 562 GQPALSSTATVTVSVCRC-------QPDGSVASCWPEAHLSAAGLSTGALLAIITCVGAL 614

Query: 703 LLLCILFTCFCVTAKRTVKKCFPEDIAQQNLIVSNTEGPGEEVTEA 748
           L L +LF       +  +     ED+ ++N+I  + EG GEE TEA
Sbjct: 615 LALVVLFVALRRQKQEALMVLEEEDV-RENIITYDDEGGGEEDTEA 659


>gi|16753221 cadherin 22 precursor [Homo sapiens]
          Length = 828

 Score =  218 bits (555), Expect = 2e-56
 Identities = 191/660 (28%), Positives = 317/660 (48%), Gaps = 52/660 (7%)

Query: 118 SPKKRHTKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQ-NYTIFYSISGPG 176
           +P  R        R KR W      ++E   G  P +V +I SD+ + +  I Y+ISG G
Sbjct: 46  APGARQDGALGAGRVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEG 105

Query: 177 VDKEPFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATT-ADGYAPEYPLPLIIKIEDD 235
                  +F I++ TGDI     +DRE+   + L   A   A     E     IIK++D 
Sbjct: 106 AG----TIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDI 161

Query: 236 NDNAPYFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDT-LHTRLKYKILQQIPDHPKHF 294
           ND+ P F H   I +V E   +GTSV +V A+D D+P      RL Y +L    D   HF
Sbjct: 162 NDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVL----DGEHHF 217

Query: 295 SIHPDTGVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSF 354
           ++ P TGVI T  P LDRE  + Y+++++  DM GQ  GL  + T+TI + D NDNPP F
Sbjct: 218 TVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRF 277

Query: 355 TETSYVTEVEENR-IDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGN--FIISTDPNT 411
            +  Y   ++E+  I   + R+K +D D+    ++   Y +   + +G   F ++TD +T
Sbjct: 278 PQKMYQFSIQESAPIGTAVGRVKAEDSDVGE--NTDMTYHLKDESSSGGDVFKVTTDSDT 335

Query: 412 NEGVLCVVKPLNYE---VNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEG 468
            E ++ V K L++E   V+  ++  +    + +F+   + +   +    V V + D DE 
Sbjct: 336 QEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAI----VRVAVTDVDEP 391

Query: 469 PECHPPVKVIQSQDGFPAGQELLGYKALDPEISSGEGLRY--QKLGDEDNWFEINQHTGD 526
           PE  PP  +++ Q+    G  +    A DP+ ++   +RY   +  D D  F+I+  TG 
Sbjct: 392 PEFRPPSGLLEVQEDAQVGSLVGVVTARDPD-AANRPVRYAIDRESDLDQIFDIDADTGA 450

Query: 527 LRTLKVLDRESKFVKNNQYNISVVAVDAVGRS--CTGTLVVHLDDYNDHAPQI--DKEVT 582
           + T K LDRE+       +NI+V+A++A   +     +L + + D ND+ P++    E  
Sbjct: 451 IVTGKGLDRETA----GWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAA 506

Query: 583 ICQN---NEDFAVLKPVDPDGPENGPPFQFFLDNSASKNWN---IEEKDGKTAILRQ--- 633
           +C++    +    +  VD D P+ G  F F L   A  N +   ++ +D   A+  Q   
Sbjct: 507 VCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVHTQHVG 566

Query: 634 --RQNLDYNYYSVPIQIKDRHGLVATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGR 691
             RQ  D  +  + +       L +T  LT+R+C C   S   ++  +T        L  
Sbjct: 567 FNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRICGCD--SSGTIQSCNTTAFVMAASLSP 624

Query: 692 WAILAMVLGSVLLLCILFTCFCVTAKRTVKKCFPED---IAQQNLIVSNTEGPGEEVTEA 748
            A++A+++   +L+ ++     +T +R  K     D     + N+I  N EG GE+ TEA
Sbjct: 625 GALIALLV--CVLILVVLVLLILTLRRHHKSHLSSDEDEDMRDNVIKYNDEGGGEQDTEA 682


>gi|119703744 desmoglein 1 preproprotein [Homo sapiens]
          Length = 1049

 Score =  218 bits (554), Expect = 2e-56
 Identities = 138/462 (29%), Positives = 229/462 (49%), Gaps = 4/462 (0%)

Query: 128 ALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFNLFYI 187
           +++R KR W    A+  E         + +I SD A N  + Y ISG G+D+ P+ +F I
Sbjct: 43  SIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVI 102

Query: 188 EKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFEHRVT 247
            + TG+I  T  +DRE    F +Y  A  + G   E PL L +++ D NDN P F     
Sbjct: 103 NQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATF 162

Query: 248 IFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDTGVITTTT 307
              + EN  + T V  + ATD DEP+ L++++ +KI++Q P     F I+ +TG I T  
Sbjct: 163 AGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMN 222

Query: 308 PFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEENR 367
            FLDRE+   Y L +   D  G   G+       I + D NDN P   ++SY  E++EN 
Sbjct: 223 NFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENT 282

Query: 368 IDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYEVN 427
           ++  +L ++V D D   + +  AV   + GNE   F I  +  TN G+L VVKPL+YE  
Sbjct: 283 LNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAM 342

Query: 428 RQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPAG 487
           + + L +GV N+A+F  +  SQ   +  + ++V +++  EGP   P  K         + 
Sbjct: 343 QSLQLSIGVRNKAEFHHSIMSQY-KLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSN 401

Query: 488 QELLGYKALDPEIS-SGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNNQYN 546
            ++  + A D +       +RY    +  +   ++  TG L     + +E   +   +Y 
Sbjct: 402 DKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQ 461

Query: 547 ISVVAV-DAVGRSCTGTLVVHLDDY-NDHAPQIDKEVTICQN 586
            +++++ D + R+CTGT+ +++  + ND     +    I  N
Sbjct: 462 GTILSIDDNLQRTCTGTININIQSFGNDDRTNTEPNTKITTN 503


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,904,469
Number of Sequences: 37866
Number of extensions: 1599035
Number of successful extensions: 6838
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 193
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 3624
Number of HSP's gapped (non-prelim): 856
length of query: 840
length of database: 18,247,518
effective HSP length: 111
effective length of query: 729
effective length of database: 14,044,392
effective search space: 10238361768
effective search space used: 10238361768
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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