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Search of human proteins with 4826669
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4826669 cadherin 15 preproprotein [Homo sapiens]
(814 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4826669 cadherin 15 preproprotein [Homo sapiens] 1641 0.0
gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens] 603 e-172
gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens] 592 e-169
gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens] 497 e-140
gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens] 496 e-140
gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens] 383 e-106
gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens] 374 e-103
gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens] 372 e-103
gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens] 372 e-103
gi|4502719 cadherin 13 preproprotein [Homo sapiens] 371 e-102
gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens] 365 e-101
gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens] 364 e-100
gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens] 363 e-100
gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens] 362 e-99
gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens] 360 3e-99
gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo sapi... 351 1e-96
gi|13435364 desmocollin 2 isoform Dsc2a preproprotein [Homo sapi... 351 1e-96
gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo sap... 344 2e-94
gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo sap... 344 2e-94
gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens] 344 2e-94
gi|32880203 cadherin-like 24 isoform 2 [Homo sapiens] 344 2e-94
gi|32880206 cadherin-like 24 isoform 1 [Homo sapiens] 331 1e-90
gi|166362713 cadherin 5, type 2 preproprotein [Homo sapiens] 328 9e-90
gi|16753221 cadherin 22 precursor [Homo sapiens] 328 9e-90
gi|29789445 desmoglein 4 isoform 2 [Homo sapiens] 301 2e-81
gi|12656655 cadherin 19, type 2 preproprotein [Homo sapiens] 301 2e-81
gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens] 297 3e-80
gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo sapi... 297 3e-80
gi|197313787 desmoglein 4 isoform 1 [Homo sapiens] 291 1e-78
gi|116534898 desmoglein 2 preproprotein [Homo sapiens] 278 1e-74
>gi|4826669 cadherin 15 preproprotein [Homo sapiens]
Length = 814
Score = 1641 bits (4250), Expect = 0.0
Identities = 814/814 (100%), Positives = 814/814 (100%)
Query: 1 MDAAFLLVLGLLAQSLCLSLGVPGWRRPTTLYPWRRAPALSRVRRAWVIPPISVSENHKR 60
MDAAFLLVLGLLAQSLCLSLGVPGWRRPTTLYPWRRAPALSRVRRAWVIPPISVSENHKR
Sbjct: 1 MDAAFLLVLGLLAQSLCLSLGVPGWRRPTTLYPWRRAPALSRVRRAWVIPPISVSENHKR 60
Query: 61 LPYPLVQIKSDKQQLGSVIYSIQGPGVDEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRL 120
LPYPLVQIKSDKQQLGSVIYSIQGPGVDEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRL
Sbjct: 61 LPYPLVQIKSDKQQLGSVIYSIQGPGVDEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRL 120
Query: 121 RAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQEAFTGRVLEGAVPGTYVTRAEATDAD 180
RAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQEAFTGRVLEGAVPGTYVTRAEATDAD
Sbjct: 121 RAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQEAFTGRVLEGAVPGTYVTRAEATDAD 180
Query: 181 DPETDNAALRFSILQQGSPELFSIDELTGEIRTVQVGLDREVVAVYNLTLQVADMSGDGL 240
DPETDNAALRFSILQQGSPELFSIDELTGEIRTVQVGLDREVVAVYNLTLQVADMSGDGL
Sbjct: 181 DPETDNAALRFSILQQGSPELFSIDELTGEIRTVQVGLDREVVAVYNLTLQVADMSGDGL 240
Query: 241 TATASAIITLDDINDNAPEFTRDEFFMEAIEAVSGVDVGRLEVEDRDLPGSPNWVARFTI 300
TATASAIITLDDINDNAPEFTRDEFFMEAIEAVSGVDVGRLEVEDRDLPGSPNWVARFTI
Sbjct: 241 TATASAIITLDDINDNAPEFTRDEFFMEAIEAVSGVDVGRLEVEDRDLPGSPNWVARFTI 300
Query: 301 LEGDPDGQFTIRTDPKTNEGVLSIVKALDYESCEHYELKVSVQNEAPLQAAALRAERGQA 360
LEGDPDGQFTIRTDPKTNEGVLSIVKALDYESCEHYELKVSVQNEAPLQAAALRAERGQA
Sbjct: 301 LEGDPDGQFTIRTDPKTNEGVLSIVKALDYESCEHYELKVSVQNEAPLQAAALRAERGQA 360
Query: 361 KVRVHVQDTNEPPVFQENPLRTSLAEGAPPGTLVATFSARDPDTEQLQRLSYSKDYDPED 420
KVRVHVQDTNEPPVFQENPLRTSLAEGAPPGTLVATFSARDPDTEQLQRLSYSKDYDPED
Sbjct: 361 KVRVHVQDTNEPPVFQENPLRTSLAEGAPPGTLVATFSARDPDTEQLQRLSYSKDYDPED 420
Query: 421 WLQVDAATGRIQTQHVLSPASPFLKGGWYRAIVLAQDDASQPRTATGTLSIEILEVNDHA 480
WLQVDAATGRIQTQHVLSPASPFLKGGWYRAIVLAQDDASQPRTATGTLSIEILEVNDHA
Sbjct: 421 WLQVDAATGRIQTQHVLSPASPFLKGGWYRAIVLAQDDASQPRTATGTLSIEILEVNDHA 480
Query: 481 PVLAPPPPGSLCSEPHQGPGLLLGATDEDLPPHGAPFHFQLSPRLPELGRNWSLSQVNVS 540
PVLAPPPPGSLCSEPHQGPGLLLGATDEDLPPHGAPFHFQLSPRLPELGRNWSLSQVNVS
Sbjct: 481 PVLAPPPPGSLCSEPHQGPGLLLGATDEDLPPHGAPFHFQLSPRLPELGRNWSLSQVNVS 540
Query: 541 HARLRPRHQVPEGLHRLSLLLRDSGQPPQQREQPLNVTVCRCGKDGVCLPGAAALLAGGT 600
HARLRPRHQVPEGLHRLSLLLRDSGQPPQQREQPLNVTVCRCGKDGVCLPGAAALLAGGT
Sbjct: 541 HARLRPRHQVPEGLHRLSLLLRDSGQPPQQREQPLNVTVCRCGKDGVCLPGAAALLAGGT 600
Query: 601 GLSLGALVIVLASALLLLVLVLLVALRARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGG 660
GLSLGALVIVLASALLLLVLVLLVALRARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGG
Sbjct: 601 GLSLGALVIVLASALLLLVLVLLVALRARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGG 660
Query: 661 EEDQDAYDISQLRHPTALSLPLGPPPLRRDAPQGRLHPQPPRVLPTSPLDIADFINDGLE 720
EEDQDAYDISQLRHPTALSLPLGPPPLRRDAPQGRLHPQPPRVLPTSPLDIADFINDGLE
Sbjct: 661 EEDQDAYDISQLRHPTALSLPLGPPPLRRDAPQGRLHPQPPRVLPTSPLDIADFINDGLE 720
Query: 721 AADSDPSVPPYDTALIYDYEGDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMY 780
AADSDPSVPPYDTALIYDYEGDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMY
Sbjct: 721 AADSDPSVPPYDTALIYDYEGDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMY 780
Query: 781 GHPCGLEYGARWDHQAREGLSPGALLPRHRGRTA 814
GHPCGLEYGARWDHQAREGLSPGALLPRHRGRTA
Sbjct: 781 GHPCGLEYGARWDHQAREGLSPGALLPRHRGRTA 814
>gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens]
Length = 916
Score = 603 bits (1554), Expect = e-172
Identities = 343/769 (44%), Positives = 465/769 (60%), Gaps = 25/769 (3%)
Query: 30 TLYPW---RRAPALSRVRRAWVIPPISVSENHKRLPYP--LVQIKSDKQQLGSVIYSIQG 84
TL PW + A L R +R WVIPPI+V EN R P+P LV+I+SDK + YSI G
Sbjct: 151 TLLPWPQHQNANGLRRRKRDWVIPPINVPEN-SRGPFPQQLVRIRSDKDNDIPIRYSITG 209
Query: 85 PGVDEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVD 144
G D+ P VFSID +G++++ +DRE+ + LRA A+D+ G+ +E+P DL I V+D
Sbjct: 210 VGADQPPMEVFSIDSMSGRMYVTRPMDREEHASYHLRAHAVDMNGNKVENPIDLYIYVID 269
Query: 145 QNDNRPAFLQEAFTGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSIL----QQGSPE 200
NDNRP F+ + + G V EG+ PGTYV A DADD T N +R+ I+ Q S
Sbjct: 270 MNDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQN 329
Query: 201 LFSIDELTGEIRTVQVGLDREVVAVYNLTLQVADMSGD---GLTATASAIITLDDINDNA 257
+F+I+ TG+I TV GLDRE V Y + +Q DM G+ GL+ TA+AIIT+ D+NDN
Sbjct: 330 MFTINSETGDIVTVAAGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNP 389
Query: 258 PEFTRDEFFMEAIEAVSGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKT 317
PEFT F E E V L V DRD P SPNW A + I+ GDP G F++RTDP T
Sbjct: 390 PEFTASTFAGEVPENRVETVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVT 449
Query: 318 NEGVLSIVKALDYESCEHYELKVSVQNEAPLQAAALRAERGQAKVRVHVQDTNEPPVFQE 377
NEG++++VKA+DYE + L V V N+APL + + + A V + + D NE P F
Sbjct: 450 NEGMVTVVKAVDYELNRAFMLTVMVSNQAPLASGIQMSFQSTAGVTISIMDINEAPYFPS 509
Query: 378 NPLRTSLAEGAPPGTLVATFSARDPDTEQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVL 437
N L EG PPGT++ TFSA DPD Q + YSK DP WL ++A G+I T VL
Sbjct: 510 NHKLIRLEEGVPPGTVLTTFSAVDPDRFMQQAVRYSKLSDPASWLHINATNGQITTAAVL 569
Query: 438 SPASPFLKGGWYRAIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQ 497
S + K Y A LA D+ P + TGTL I ++++ND+AP L P +C +P+
Sbjct: 570 DRESLYTKNNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPELL-PKEAQICEKPNL 628
Query: 498 GPGLLLGATDEDLPPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRHQVPE-GLHR 556
+ + A D D+ P+ P+ F+L + +NW+++++N +A+L R E G++
Sbjct: 629 N-AINITAADADVDPNIGPYVFELPFVPAAVRKNWTITRLNGDYAQLSLRILYLEAGMYD 687
Query: 557 LSLLLRDSGQPPQQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLGALVIVLASALL 616
+ +++ DSG PP + V VC C +G C A A GL GA+V +L L+
Sbjct: 688 VPIIVTDSGNPPLSNTSIIKVKVCPCDDNGDCTTIGAVAAA---GLGTGAIVAILICILI 744
Query: 617 LLVLVLL-VALRARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHP 675
LL +VLL V R K+ K LL P+DD+RDN+L YDE+GGGEEDQD YD+SQL+ P
Sbjct: 745 LLTMVLLFVMWMKRREKERHTKQLLIDPEDDVRDNILKYDEEGGGEEDQD-YDLSQLQQP 803
Query: 676 TALS-LPLGPPPLRR--DAPQGRLHPQPPRVLPTSPLDIADFINDGLEAADSDPSVPPYD 732
A+ +P P +RR + P G P R + P DI DFIN+GL AAD+DP+ PPYD
Sbjct: 804 EAMGHVPSKAPGVRRVDERPVGAEPQYPIRPMVPHPGDIGDFINEGLRAADNDPTAPPYD 863
Query: 733 TALIYDYEGDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMYG 781
+ L++DYEG GS AG++SS L+S DQDYDYL DWGPRF +LADMYG
Sbjct: 864 SLLVFDYEGSGSTAGSVSS-LNSSSSGDQDYDYLNDWGPRFKKLADMYG 911
>gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens]
Length = 906
Score = 592 bits (1525), Expect = e-169
Identities = 325/756 (42%), Positives = 458/756 (60%), Gaps = 21/756 (2%)
Query: 40 LSRVRRAWVIPPISVSENHKRLPYP--LVQIKSDKQQLGSVIYSIQGPGVDEEPRGVFSI 97
L R +R WVIPPI++ EN R P+P LV+I+SD+ + S+ YS+ GPG D+ P G+F I
Sbjct: 154 LQRQKRDWVIPPINLPEN-SRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFII 212
Query: 98 DKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQEAF 157
+ +G++ + LDRE+ RF LRA A+D+ G+ +E+P D+ I V+D NDNRP FL + +
Sbjct: 213 NPISGQLSVTKPLDREQIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVW 272
Query: 158 TGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQG----SPELFSIDELTGEIRT 213
G V EG+ PGTYV A DADDP N LR+ I+ Q SP +F+I+ TG+I T
Sbjct: 273 NGTVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRIVSQAPSTPSPNMFTINNETGDIIT 332
Query: 214 VQVGLDREVVAVYNLTLQVADMSGD---GLTATASAIITLDDINDNAPEFTRDEFFMEAI 270
V GLDRE V Y L +Q DM G+ GL+ TA+A+IT+ D+NDN PEFT F+ E
Sbjct: 333 VAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVP 392
Query: 271 EAVSGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDY 330
E + V L V D+D P +P W A + I GDP G+F I+TDP +N+G++++VK +D+
Sbjct: 393 ENRVDIIVANLTVTDKDQPHTPAWNAVYRISGGDPTGRFAIQTDPNSNDGLVTVVKPIDF 452
Query: 331 ESCEHYELKVSVQNEAPLQAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPP 390
E+ + L V+ +N+ PL + A V V V D NE P F NP EG
Sbjct: 453 ETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEEGLHA 512
Query: 391 GTLVATFSARDPDTEQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYR 450
GT++ TF+A+DPD Q + Y+K DP +WL++D G+I T VL SP +K Y
Sbjct: 513 GTMLTTFTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESPNVKNNIYN 572
Query: 451 AIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGLLLGATDEDL 510
A LA D+ P + TGTL I +L++ND+AP + P C P + + A D D+
Sbjct: 573 ATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVL-PQEAETCETPDPN-SINITALDYDI 630
Query: 511 PPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRHQVPE-GLHRLSLLLRDSGQPPQ 569
P+ PF F L + RNW+++++N A+L + + E G++ + +++ DSG PP+
Sbjct: 631 DPNAGPFAFDLPLSPVTIKRNWTITRLNGDFAQLNLKIKFLEAGIYEVPIIITDSGNPPK 690
Query: 570 QREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLGALVIVLASALLLLVLVLL-VALRA 628
L V VC+C +G C + G GL GA++ +L ++LL+LVL+ V
Sbjct: 691 SNISILRVKVCQCDSNGDCTDVDRIV---GAGLGTGAIIAILLCIIILLILVLMFVVWMK 747
Query: 629 RFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHPTALSLPLGPPPLR 688
R K+ + K LL P+DD+RDN+L YDE+GGGEEDQD YD+SQL+ P + P
Sbjct: 748 RRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQD-YDLSQLQQPDTVEPDAIKPVGI 806
Query: 689 RDAPQGRLHPQPP---RVLPTSPLDIADFINDGLEAADSDPSVPPYDTALIYDYEGDGSV 745
R + +H +P R P DI DFIN+GL+AAD+DP+ PPYD+ L++DYEG GS
Sbjct: 807 RRMDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLLVFDYEGSGST 866
Query: 746 AGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMYG 781
AG+LSS+ SS +QDYDYL DWGPRF +LADMYG
Sbjct: 867 AGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYG 902
>gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens]
Length = 829
Score = 497 bits (1279), Expect = e-140
Identities = 312/767 (40%), Positives = 426/767 (55%), Gaps = 43/767 (5%)
Query: 26 RRPTTLYPWRRAPALSRVRRAWVIPPISVSENHKRLPYP--LVQIKSDKQQLGSVIYSIQ 83
R P ++P +R L R +R WV+ PISV EN K P+P L Q+KS+K + + YSI
Sbjct: 90 RNPLKIFPSKRI--LRRHKRDWVVAPISVPENGKG-PFPQRLNQLKSNKDRDTKIFYSIT 146
Query: 84 GPGVDEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVV 143
GPG D P GVF+++K TG + LN LDRE+ ++ L A+ G+++EDP ++ I+V
Sbjct: 147 GPGADSPPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVT 206
Query: 144 DQNDNRPAFLQEAFTGRVLEGAVPGTYVTRAEATDADDP-ETDNAALRFSILQQGSPE-- 200
DQND++P F Q+ F G VLEG +PGT V + ATD DD T N + +SI Q +
Sbjct: 207 DQNDHKPKFTQDTFRGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPH 266
Query: 201 --LFSIDELTGEIRTVQVGLDREVVAVYNLTLQVADMSGDGLTATASAIITLDDINDNAP 258
+F+I TG I + GLDRE V Y LT+Q DM GDG T TA A++ + D NDNAP
Sbjct: 267 DLMFTIHRSTGTISVISSGLDREKVPEYTLTIQATDMDGDGSTTTAVAVVEILDANDNAP 326
Query: 259 EFTRDEFFMEAIEAVSGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTN 318
F ++ E G +V RL V D D P SP W A + I+ GD FTI T P++N
Sbjct: 327 MFDPQKYEAHVPENAVGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPESN 386
Query: 319 EGVLSIVKALDYESCEHYELKVSVQNEAPLQAAALRAERGQAKVRVHVQDTNEPPVFQEN 378
+G+L+ K LD+E+ + L V V NEAP L+ A + VHV+D NE PVF
Sbjct: 387 QGILTTRKGLDFEAKNQHTLYVEVTNEAPF---VLKLPTSTATIVVHVEDVNEAPVFVPP 443
Query: 379 PLRTSLAEGAPPGTLVATFSARDPDTEQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLS 438
+ EG P G V ++A DPD E Q++SY DP WL +D +G++ L
Sbjct: 444 SKVVEVQEGIPTGEPVCVYTAEDPDKEN-QKISYRILRDPAGWLAMDPDSGQVTAVGTLD 502
Query: 439 -PASPFLKGGWYRAIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQ 497
F++ Y +VLA D+ S P T TGTL + +++VNDH PV P P +
Sbjct: 503 REDEQFVRNNIYEVMVLAMDNGSPPTTGTGTLLLTLIDVNDHGPV---PEPRQITICNQS 559
Query: 498 GPGLLLGATDEDLPPHGAPFHFQLSPRLPELGRNWSLSQVNV--SHARLRPRHQVPEGLH 555
+L TD+DL PH +PF QL+ + W+ ++VN L + + + +
Sbjct: 560 PVRQVLNITDKDLSPHTSPFQAQLT---DDSDIYWT-AEVNEEGDTVVLSLKKFLKQDTY 615
Query: 556 RLSLLLRDSGQPPQQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLGALVIVLASAL 615
+ L L D G +++ + TVC C PG G L L VLA
Sbjct: 616 DVHLSLSDHGN--KEQLTVIRATVCDCHGHVETCPG-----PWKGGFILPVLGAVLALLF 668
Query: 616 LLLVLVLLVALRARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHP 675
LLLVL+LLV K+ + K L P+DD RDNV Y E+GGGEEDQD YDI+QL
Sbjct: 669 LLLVLLLLVR------KKRKIKEPLLLPEDDTRDNVFYYGEEGGGEEDQD-YDITQLHR- 720
Query: 676 TALSLPLGPPPLRRDAPQGRLHPQPP-RVLPTSPLDIADFINDGLEAADSDPSVPPYDTA 734
L P + R+ + P P R P +P +I +FI + L+AA++DP+ PPYDT
Sbjct: 721 ---GLEARPEVVLRNDVAPTIIPTPMYRPRPANPDEIGNFIIENLKAANTDPTAPPYDTL 777
Query: 735 LIYDYEGDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMYG 781
L++DYEG GS A +LSS+ SS D+DQDYDYL +WG RF +LADMYG
Sbjct: 778 LVFDYEGSGSDAASLSSLTSSASDQDQDYDYLNEWGSRFKKLADMYG 824
>gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens]
Length = 882
Score = 496 bits (1277), Expect = e-140
Identities = 309/761 (40%), Positives = 440/761 (57%), Gaps = 45/761 (5%)
Query: 37 APALSRVRRAWVIPPISVSENHKRLPYP--LVQIKSDKQQLGSVIYSIQGPGVDEEPRGV 94
+P L R +R WVIPPIS EN K P+P LVQIKS+K + G V YSI G G D P GV
Sbjct: 146 SPGLRRQKRDWVIPPISCPENEKG-PFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGV 204
Query: 95 FSIDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQ 154
F I++ TG + + LDRE+ + L + A+ G+ +EDP ++ I V DQNDN+P F Q
Sbjct: 205 FIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQ 264
Query: 155 EAFTGRVLEGAVPGTYVTRAEATDADDP-ETDNAALRFSILQQGSPEL-----FSIDELT 208
E F G V+EGA+PGT V ATDADD T NAA+ ++IL Q PEL F+I+ T
Sbjct: 265 EVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQ-DPELPDKNMFTINRNT 323
Query: 209 GEIRTVQVGLDREVVAVYNLTLQVADMSGDGLTATASAIITLDDINDNAPEFTRDEFFME 268
G I V GLDRE Y L +Q AD+ G+GL+ TA+A+IT+ D NDN P F + +
Sbjct: 324 GVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQ 383
Query: 269 AIEAVSGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKAL 328
E + V + L+V D D P +P W A +TIL D GQF + T+P N+G+L K L
Sbjct: 384 VPENEANVVITTLKVTDADAPNTPAWEAVYTIL-NDDGGQFVVTTNPVNNDGILKTAKGL 442
Query: 329 DYESCEHYELKVSVQNEAPLQAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGA 388
D+E+ + Y L V+V N P + + + A V V V D NE P+F R ++E
Sbjct: 443 DFEAKQQYILHVAVTNVVPFEVSLTTS---TATVTVDVLDVNEAPIFVPPEKRVEVSEDF 499
Query: 389 PPGTLVATFSARDPDTEQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPAS-PFLKGG 447
G + +++A++PDT Q+++Y D +WL+++ TG I T+ L +K
Sbjct: 500 GVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNS 559
Query: 448 WYRAIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGLLLGATD 507
Y A+++A D+ S T TGTL + + +VND+AP+ P P E + P ++ D
Sbjct: 560 TYTALIIATDNGSPVATGTGTLLLILSDVNDNAPI--PEPRTIFFCERNPKP-QVINIID 616
Query: 508 EDLPPHGAPFHFQLSPRLPELGRNWSLSQVNVSHAR--LRPRHQVPEGLHRLSLLLRDSG 565
DLPP+ +PF +L+ NW++ + + L+P+ + G ++++L L D+
Sbjct: 617 ADLPPNTSPFTAELT---HGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDN- 672
Query: 566 QPPQQREQ--PLNVTVCRC-GKDGVCLPGAAALLAGGTGLSLGALVIVLASALLLLVLVL 622
Q ++Q L V+VC C G GVC GL + A++ +L L LL+L+L
Sbjct: 673 ---QNKDQVTTLEVSVCDCEGAAGVCRKAQPV----EAGLQIPAILGILGGILALLILIL 725
Query: 623 LVALRARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHPTALSLPL 682
L+ L R +++ K L P+DD RDNV YDE+GGGEEDQD +D+SQL L
Sbjct: 726 LLLLFLR--RRAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQD-FDLSQLHR----GLDA 778
Query: 683 GPPPLRRDAPQGRLHPQPPRVL--PTSPLDIADFINDGLEAADSDPSVPPYDTALIYDYE 740
P R D + PR L P +P +I +FI++ L+AAD+DP+ PPYD+ L++DYE
Sbjct: 779 RPEVTRNDVAPTLM--SVPRYLPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYE 836
Query: 741 GDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMYG 781
G GS A +LSS+ SS+ D+DQDYDYL +WG RF +LADMYG
Sbjct: 837 GSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLADMYG 877
>gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens]
Length = 796
Score = 383 bits (984), Expect = e-106
Identities = 268/799 (33%), Positives = 410/799 (51%), Gaps = 41/799 (5%)
Query: 4 AFLLVLGLLAQSLCLSLGVPGWRRPTTL---YPWRRAPALSRVRRAWVIPPISVSENHKR 60
A L+ LG+L S + G RP+ + L R +R WV V E +
Sbjct: 9 AALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTG 68
Query: 61 LPYPLV--QIKSDKQQL-GSVIYSIQGPGVDEEPRGVFSIDKFTGKVFLNAMLDREKTDR 117
P P++ ++ SD G++ Y + G G +F ID +G + LDRE+ +
Sbjct: 69 -PDPVLVGRLHSDIDSGDGNIKYILSGEGAGT----IFVIDDKSGNIHATKTLDREERAQ 123
Query: 118 FRLRAFALDLGGST-LEDPTDLEIVVVDQNDNRPAFLQEAFTGRVLEGAVPGTYVTRAEA 176
+ L A A+D + LE P++ + V D NDN P FL E + V E + GT V + A
Sbjct: 124 YTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTA 183
Query: 177 TDADDPETDNAA-LRFSILQQGSPELFSIDELTGEIRTVQVGLDREVVAVYNLTLQVADM 235
+DADDP N+A L +SIL+ G P FS++ TG IRT +DRE Y++ +Q DM
Sbjct: 184 SDADDPTYGNSAKLVYSILE-GQP-YFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDM 241
Query: 236 SGD--GLTATASAIITLDDINDNAPEFTRDEFFMEAIEA-VSGVDVGRLEVEDRDLPGSP 292
G GL+ T ITL D+NDN P+F + + M EA V G +VGR++ +D D+
Sbjct: 242 GGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDI--GE 299
Query: 293 NWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESCEHYELKVSVQN-EAPLQAA 351
N + + I++GD F I TD +T EGV+ + K +D+E+ Y LKV N +
Sbjct: 300 NGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFI 359
Query: 352 ALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGTLVATFSARDPDTEQLQ-RL 410
+ + V++ V+D +EPP+F + E A GT+V A+DPD R
Sbjct: 360 SNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRY 419
Query: 411 SYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYRAIVLAQDDASQPRTATGTLS 470
S + D + + ++ G I+T L W V A + ++ + A ++
Sbjct: 420 SIDRHTDLDRFFTINPEDGFIKTTKPLDREET----AWLNITVFAAEIHNRHQEAKVPVA 475
Query: 471 IEILEVNDHAPVLAPPPPGSLCSEPH-----QGPGLLLGATDEDLPPHGAPFHFQLSPRL 525
I +L+VND+AP A P G +C P + + A D+D +G F F L P +
Sbjct: 476 IRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEI 535
Query: 526 ---PELGRNWSLSQVNVSHARLRPRHQVPEGLHRLSLLLRDSGQPPQQREQPLNVTVCRC 582
P + +AR + + L+ L +++ D G PP L + VC C
Sbjct: 536 IHNPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGC 595
Query: 583 GKDGVCLPGAAALLAGGTGLSLGALVIVLASALLLLVLVLLVALRARFWKQSRGKGLLHG 642
+G L A GLS GAL+ +LA ++LLV+V+L R K+ L+
Sbjct: 596 DVNGALLSCNAEAYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQKKEP----LIVF 651
Query: 643 PQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHPTALSLPLGPPPLRRDAPQGRLHPQPPR 702
++D+R+N++ YD++GGGEED +A+DI+ L++P ++ G P + P+ + P+P
Sbjct: 652 EEEDVRENIITYDDEGGGEEDTEAFDIATLQNPDGIN---GFIPRKDIKPEYQYMPRPGL 708
Query: 703 VLPTSPLDIADFINDGLEAADSDPSVPPYDTALIYDYEGDGSVAGTLSSILSSQGDEDQD 762
+ +D+ DFIN ++ AD+DP+ PPYD+ IY YEG GSVAG+LSS+ S+ D D D
Sbjct: 709 RPAPNSVDVDDFINTRIQEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESATTDSDLD 768
Query: 763 YDYLRDWGPRFARLADMYG 781
YDYL++WGPRF +LAD+YG
Sbjct: 769 YDYLQNWGPRFKKLADLYG 787
>gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens]
Length = 794
Score = 374 bits (960), Expect = e-103
Identities = 264/755 (34%), Positives = 380/755 (50%), Gaps = 37/755 (4%)
Query: 42 RVRRAWVIPPISVSENHKRL-PYPLVQIKSDKQQ-LGSVIYSIQGPGVDEEPRGVFSIDK 99
RV+R WV V E + P + ++ SD + G+V Y++ G G VF+ID+
Sbjct: 51 RVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGT----VFTIDE 106
Query: 100 FTGKVFLNAMLDREKTDRFRLRAFALDLGG-STLEDPTDLEIVVVDQNDNRPAFLQEAFT 158
TG + LDRE+ + LRA A+D+ LE ++ I V D NDN P FL +
Sbjct: 107 TTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYV 166
Query: 159 GRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQGSPELFSIDELTGEIRTVQVGL 218
V E + G YV + +ATDADDP N+A + QG P FSID TG IRT +
Sbjct: 167 ATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQP-YFSIDPKTGVIRTALPNM 225
Query: 219 DREVVAVYNLTLQVADMSGD--GLTATASAIITLDDINDNAPEFTRDEFFMEAIEAVS-G 275
DREV Y + +Q DM G GL T ITL D+NDN P F + F ++ E+ G
Sbjct: 226 DREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIG 285
Query: 276 VDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESCEH 335
+GR+ D D N + I+ GD F I TD T EGV+ + K LD+E+ +
Sbjct: 286 SAIGRIRAVDPDF--GQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKA 343
Query: 336 YELKVSVQN-EAPLQAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGTLV 394
Y KV N + + + A V++ V D +EPPVF + + E P GT++
Sbjct: 344 YTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTII 403
Query: 395 ATFSARDPDTEQLQRLSYSKDY--DPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYRAI 452
+A+D D + Y D+ D + + +D G I T +L S Y
Sbjct: 404 GAVTAQDLDVGS-SAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDREST----AQYNFS 458
Query: 453 VLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGL-LLGATDEDLP 511
++A ++ T+ + I +L+VN+ P ++ P ++C G + ++ A D DL
Sbjct: 459 IIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLS 518
Query: 512 PHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRH----QVPEGLHRLSLLLRDSGQP 567
P G F F+LSP + N+++ + A + R + + L+ L +++ DS P
Sbjct: 519 PAGQQFSFRLSPEAA-IKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYP 577
Query: 568 PQQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLGALV-IVLASALLLLVLVLLVAL 626
Q + + VCRC DG L + GLS GAL+ I+L +LL ++VL VAL
Sbjct: 578 VQSSTNTMTIRVCRCDSDGTILSCNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVAL 637
Query: 627 RARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHPTALSLPLGPPP 686
R + + K L ++D+RDNV++YD++GGGEED A+DI LR+P +
Sbjct: 638 R-----RQKKKDTLMTSKEDIRDNVIHYDDEGGGEEDTQAFDIGALRNPKVIE----ENK 688
Query: 687 LRRDAPQGRLHPQPPRVLPTSPLDIADFINDGLEAADSDPSVPPYDTALIYDYEGDGSVA 746
+RRD L R DI DFI+ L+ D DP+ PPYD+ Y YEG GSVA
Sbjct: 689 IRRDIKPDSLCLPRQRPPMEDNTDIRDFIHQRLQENDVDPTAPPYDSLATYAYEGSGSVA 748
Query: 747 GTLSSILSSQGDEDQDYDYLRDWGPRFARLADMYG 781
+LSSI S + DQDYDYL DWGPRF LADM+G
Sbjct: 749 ESLSSIDSLTTEADQDYDYLTDWGPRFKVLADMFG 783
>gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens]
Length = 785
Score = 372 bits (955), Expect = e-103
Identities = 256/755 (33%), Positives = 384/755 (50%), Gaps = 34/755 (4%)
Query: 41 SRVRRAWVIPPISVSENHKRL-PYPLVQIKSDKQQL-GSVIYSIQGPGVDEEPRGVFSID 98
SR +R+WV V E + P + ++ SD + GS+ Y + G G +F ID
Sbjct: 43 SRTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASS----IFIID 98
Query: 99 KFTGKVFLNAMLDREKTDRFRLRAFALD-LGGSTLEDPTDLEIVVVDQNDNRPAFLQEAF 157
+ TG + LDRE+ + LRA ALD L +E ++ I + D NDN P FL +
Sbjct: 99 ENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPY 158
Query: 158 TGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQGSPELFSIDELTGEIRTVQVG 217
T V E + GT V + ATDADDP N+A + QG P FS++ TG I+T
Sbjct: 159 TAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQP-YFSVEPKTGVIKTALPN 217
Query: 218 LDREVVAVYNLTLQVADMSGD--GLTATASAIITLDDINDNAPEFTRDEFFMEAIEAVSG 275
+DRE Y L +Q DM G GL+ T S +TL D+NDN P F R + E++
Sbjct: 218 MDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPV 277
Query: 276 VDV-GRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESCE 334
V R++ D D+ N + I++GD G F I D +T EG+++I K LD+E+
Sbjct: 278 ASVVARIKAADADI--GANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKT 335
Query: 335 HYELKVSVQN-EAPLQAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGTL 393
Y L++ N +A + +L V++ V+D +EPPVF ++E G +
Sbjct: 336 SYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNI 395
Query: 394 VATFSARDPDTEQLQ-RLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYRAI 452
+ T +A DPD+ R S ++ D E + +DA +G I T L + + +
Sbjct: 396 IGTVAAHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAI----HNIT 451
Query: 453 VLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGLL-LGATDEDLP 511
VLA + + + G ++I IL++ND+AP A ++C G + + A D+D P
Sbjct: 452 VLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKDEP 511
Query: 512 PHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRH----QVPEGLHRLSLLLRDSGQP 567
+G F+F L+ N+SL + A + R + + ++ L + + DSG P
Sbjct: 512 SNGHQFYFSLTTDATN-NHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSP 570
Query: 568 PQQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLGALVIVLASALLLLVLVLLVALR 627
L + VC C DGV A GLS GAL+ +LA L LLVL+LL+
Sbjct: 571 SLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILLIVTM 630
Query: 628 ARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHPTALSLPLGPPPL 687
R K+ L+ + D+R+N++ YD++GGGEED +A+D++ LR+ +
Sbjct: 631 RRRKKEP----LIFDEERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNVIR----DTKT 682
Query: 688 RRDA-PQGRLHPQPPRVLPTSPLDIADFINDGLEAADSDPSVPPYDTALIYDYEGDGSVA 746
RRD P+ + +P + +FI + L+ AD DP PPYD+ Y +EG+GSVA
Sbjct: 683 RRDVTPEIQFLSRPAFKSIPDNVIFREFIWERLKEADVDPGAPPYDSLQTYAFEGNGSVA 742
Query: 747 GTLSSILSSQGDEDQDYDYLRDWGPRFARLADMYG 781
+LSS+ S + DQ+YDYL DWGPRF RLADMYG
Sbjct: 743 ESLSSLDSISSNSDQNYDYLSDWGPRFKRLADMYG 777
>gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens]
Length = 785
Score = 372 bits (955), Expect = e-103
Identities = 256/755 (33%), Positives = 384/755 (50%), Gaps = 34/755 (4%)
Query: 41 SRVRRAWVIPPISVSENHKRL-PYPLVQIKSDKQQL-GSVIYSIQGPGVDEEPRGVFSID 98
SR +R+WV V E + P + ++ SD + GS+ Y + G G +F ID
Sbjct: 43 SRTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASS----IFIID 98
Query: 99 KFTGKVFLNAMLDREKTDRFRLRAFALD-LGGSTLEDPTDLEIVVVDQNDNRPAFLQEAF 157
+ TG + LDRE+ + LRA ALD L +E ++ I + D NDN P FL +
Sbjct: 99 ENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPY 158
Query: 158 TGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQGSPELFSIDELTGEIRTVQVG 217
T V E + GT V + ATDADDP N+A + QG P FS++ TG I+T
Sbjct: 159 TAGVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQP-YFSVEPKTGVIKTALPN 217
Query: 218 LDREVVAVYNLTLQVADMSGD--GLTATASAIITLDDINDNAPEFTRDEFFMEAIEAVSG 275
+DRE Y L +Q DM G GL+ T S +TL D+NDN P F R + E++
Sbjct: 218 MDREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPV 277
Query: 276 VDV-GRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESCE 334
V R++ D D+ N + I++GD G F I D +T EG+++I K LD+E+
Sbjct: 278 ASVVARIKAADADI--GANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKT 335
Query: 335 HYELKVSVQN-EAPLQAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGTL 393
Y L++ N +A + +L V++ V+D +EPPVF ++E G +
Sbjct: 336 SYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNI 395
Query: 394 VATFSARDPDTEQLQ-RLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYRAI 452
+ T +A DPD+ R S ++ D E + +DA +G I T L + + +
Sbjct: 396 IGTVAAHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAI----HNIT 451
Query: 453 VLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGLL-LGATDEDLP 511
VLA + + + G ++I IL++ND+AP A ++C G + + A D+D P
Sbjct: 452 VLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKDEP 511
Query: 512 PHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRH----QVPEGLHRLSLLLRDSGQP 567
+G F+F L+ N+SL + A + R + + ++ L + + DSG P
Sbjct: 512 SNGHQFYFSLTTDATN-NHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSP 570
Query: 568 PQQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLGALVIVLASALLLLVLVLLVALR 627
L + VC C DGV A GLS GAL+ +LA L LLVL+LL+
Sbjct: 571 SLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILLIVTM 630
Query: 628 ARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHPTALSLPLGPPPL 687
R K+ L+ + D+R+N++ YD++GGGEED +A+D++ LR+ +
Sbjct: 631 RRRKKEP----LIFDEERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNVIR----DTKT 682
Query: 688 RRDA-PQGRLHPQPPRVLPTSPLDIADFINDGLEAADSDPSVPPYDTALIYDYEGDGSVA 746
RRD P+ + +P + +FI + L+ AD DP PPYD+ Y +EG+GSVA
Sbjct: 683 RRDVTPEIQFLSRPAFKSIPDNVIFREFIWERLKEADVDPGAPPYDSLQTYAFEGNGSVA 742
Query: 747 GTLSSILSSQGDEDQDYDYLRDWGPRFARLADMYG 781
+LSS+ S + DQ+YDYL DWGPRF RLADMYG
Sbjct: 743 ESLSSLDSISSNSDQNYDYLSDWGPRFKRLADMYG 777
>gi|4502719 cadherin 13 preproprotein [Homo sapiens]
Length = 713
Score = 371 bits (953), Expect = e-102
Identities = 224/579 (38%), Positives = 326/579 (56%), Gaps = 21/579 (3%)
Query: 31 LYPWRRAPALSRVRRAWVIPPISVSENHKRLPYPL---VQIKSDKQQLGSVIYSIQGPGV 87
++ + R + R +R+ V+ PI + EN +R P+P + SD+ + + + G GV
Sbjct: 124 IFKFARTSPVPRQKRSIVVSPILIPEN-QRQPFPRDVGKVVDSDRPERSK--FRLTGKGV 180
Query: 88 DEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQND 147
D+EP+G+F I++ TG V + LDRE ++L D+ G TLE P LE++V+DQND
Sbjct: 181 DQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIVIDQND 240
Query: 148 NRPAFLQEAFTGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQG----SPELFS 203
NRP F + + G V+EG+ GT V R A DADDP TDNA LR++I QQ SP +F
Sbjct: 241 NRPIFREGPYIGHVMEGSPTGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFY 300
Query: 204 IDELTGEIRTV--QVGLDREVVA--VYNLTLQVADMSG--DGLTATASAIITLDDINDNA 257
ID G+I TV LDRE + Y L ++ DM+G GLT TA+A I +DD ND++
Sbjct: 301 IDPEKGDIVTVVSPALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIMIDDKNDHS 360
Query: 258 PEFTRDEFFMEAIEAVSGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKT 317
P+FT+ EF E GV V L VED+D P + W A +TI+ G+P F I T+P+T
Sbjct: 361 PKFTKKEFQATVEEGAVGVIVN-LTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQT 419
Query: 318 NEGVLSIVKALDYESCEHYELKVSVQNEAPLQAAALRAERGQAKVRVHVQDTNEPPVFQE 377
NEG+LS+VK LDYE + L + V+NE PL A V + V D NE PVF
Sbjct: 420 NEGMLSVVKPLDYEISAFHTLLIKVENEDPLVPDVSYGPSSTATVHITVLDVNEGPVFYP 479
Query: 378 NPLRTSLAEGAPPGTLVATFSARDPDTEQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVL 437
+P+ + E G+++ T +A DPD+ Q Q + YS DP WL ++ G + T VL
Sbjct: 480 DPMMVTRQEDLSVGSVLLTVNATDPDSLQHQTIRYSVYKDPAGWLNINPINGTVDTTAVL 539
Query: 438 SPASPFLKGGWYRAIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQ 497
SPF+ Y A+ LA D + P T TGTL I + +VND+AP + P +C +
Sbjct: 540 DRESPFVDNSVYTALFLAIDSGNPPATGTGTLLITLEDVNDNAPFIY-PTVAEVCDDAKN 598
Query: 498 GPGLLLGATDEDLPPHGAPFHFQLSPR-LPELGRNWSLSQVNVSHARLRPRHQVPEGLHR 556
++LGA+D+DL P+ PF F++ + +P+ + W +S++N +HA + + + +
Sbjct: 599 LSVVILGASDKDLHPNTDPFKFEIHKQAVPD--KVWKISKINNTHALVSLLQNLNKANYN 656
Query: 557 LSLLLRDSGQPPQQREQPLNVTVCRCGKDGVCLPGAAAL 595
L +++ DSG+PP L V VC C V A AL
Sbjct: 657 LPIMVTDSGKPPMTNITDLRVQVCSCRNSKVDCNAAGAL 695
>gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens]
Length = 790
Score = 365 bits (938), Expect = e-101
Identities = 260/759 (34%), Positives = 394/759 (51%), Gaps = 41/759 (5%)
Query: 40 LSRVRRAWVIPPISVSENHKRLPYPLV-QIKSDKQQL-GSVIYSIQGPGVDEEPRGVFSI 97
L+R +R+W+ + E + Y V ++ SD+ + GS+ Y + G G + +F I
Sbjct: 48 LNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGD----LFII 103
Query: 98 DKFTGKVFLNAMLDREKTDRFRLRAFALDLG-GSTLEDPTDLEIVVVDQNDNRPAFLQEA 156
++ TG + LDRE+ + LRA A++ G +E ++ I + D NDN P F +E
Sbjct: 104 NENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEV 163
Query: 157 FTGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQGSPELFSIDELTGEIRTVQV 216
+T V E + GT+V + ATDADDP N+A + QG P FS++ TG I+T +
Sbjct: 164 YTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQP-YFSVESETGIIKTALL 222
Query: 217 GLDREVVAVYNLTLQVADMSGD--GLTATASAIITLDDINDNAPEFTRDEFFMEAIEAVS 274
+DRE Y + +Q DM G GL+ T + ITL D+NDN P F + + + E+
Sbjct: 223 NMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSP 282
Query: 275 -GVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESC 333
G +GR++ D D+ N ++I +G+ F + TD +T EG++++ K LD+E
Sbjct: 283 PGTPIGRIKASDADV--GENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKK 340
Query: 334 EHYELKVSVQNE-APLQAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGT 392
+ Y LKV N + L + A VR+ V+D +EPPVF + + E A T
Sbjct: 341 KVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINT 400
Query: 393 LVATFSARDPDTEQLQ-RLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYRA 451
+ + +A+DPD + + S + D + +D+ G I T +L + W+
Sbjct: 401 TIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLL----WHNI 456
Query: 452 IVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGL-LLGATDEDL 510
V+A + + +++ L I++L+VND+AP A +C + + L A D+D
Sbjct: 457 TVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDD 516
Query: 511 PPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPR------HQVPEGLHRLSLLLRDS 564
P G F F L+P G N+++ + A + R H++ L L +++ D+
Sbjct: 517 PYSGHQFSFSLAPEAAS-GSNFTIQDNKDNTAGILTRKNGYNRHEMSTYL--LPVVISDN 573
Query: 565 GQPPQQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLGALVIVLASALLLLVLVLLV 624
P Q + V VC C G A L TGLS GALV +L ++LLV V+L
Sbjct: 574 DYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGALVAILLCIVILLVTVVLF 633
Query: 625 ALRARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHPTALSLPLGP 684
A R R K L ++D+RDN+++Y+++GGGEED A+DI LR+P A+
Sbjct: 634 AALRR----QRKKEPLIISKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPEAIE----D 685
Query: 685 PPLRRDAPQGRLHPQPPRVLPTSP--LDIADFINDGLEAADSDPSVPPYDTALIYDYEGD 742
LRRD L PR PT+ D+ DFIN L+ D+DP+ PPYD+ Y YEG
Sbjct: 686 NKLRRDIVPEALFL--PRRTPTARDNTDVRDFINQRLKENDTDPTAPPYDSLATYAYEGT 743
Query: 743 GSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMYG 781
GSVA +LSS+ S D DQDYDYL DWGPRF +LADMYG
Sbjct: 744 GSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLADMYG 782
>gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens]
Length = 790
Score = 364 bits (934), Expect = e-100
Identities = 259/756 (34%), Positives = 380/756 (50%), Gaps = 39/756 (5%)
Query: 42 RVRRAWVIPPISVSENHKRLPYPL----VQIKSDKQQLGSVIYSIQGPGVDEEPRGVFSI 97
R +R WV V E H P P + SDK GSV Y + G G +F I
Sbjct: 50 RPKRGWVWNQFFVLEEHMG-PDPQYVGKLHSNSDKGD-GSVKYILTGEGAGT----IFII 103
Query: 98 DKFTGKVFLNAMLDREKTDRFRLRAFALDLG-GSTLEDPTDLEIVVVDQNDNRPAFLQEA 156
D TG + LDRE+ + L A A+D LE ++ I V D NDN P F
Sbjct: 104 DDTTGDIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFTDGP 163
Query: 157 FTGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQGSPELFSIDELTGEIRTVQV 216
+ V E + GT V + ATDADDP N+A + QG P FS+D TG IRT
Sbjct: 164 YIVTVPEMSDMGTSVLQVTATDADDPTYGNSARVVYSILQGQP-YFSVDPKTGVIRTALH 222
Query: 217 GLDREVVAVYNLTLQVADMSGD--GLTATASAIITLDDINDNAPEFTRDEFFMEAIEAVS 274
+DRE Y++ +Q DM+G GL+ + + ITL D+NDN P F + + + E+
Sbjct: 223 NMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPESAQ 282
Query: 275 -GVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESC 333
G VG+++ D D + + ++I+ GD G F+I TD +T EG+LS+ K L+YE
Sbjct: 283 VGSAVGKIKANDADTGSNADMT--YSIINGDGMGIFSISTDKETREGILSLKKPLNYEKK 340
Query: 334 EHYELKVSVQN-EAPLQAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGT 392
+ Y L + N + + L + +++ V D +EPP+F + E A GT
Sbjct: 341 KSYTLNIEGANTHLDFRFSHLGPFKDATMLKIIVGDVDEPPLFSMPSYLMEVYENAKIGT 400
Query: 393 LVATFSARDPD-TEQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYRA 451
+V T A+DPD T L R + + + + + +DA TG I+T VL WY
Sbjct: 401 VVGTVLAQDPDSTNSLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDREET----PWYNI 456
Query: 452 IVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGL-LLGATDEDL 510
V A + + + T+ I +L+VND+ P LA +C G + + ATD+D
Sbjct: 457 TVTASEIDNPDLLSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTISATDKDD 516
Query: 511 PPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRHQ----VPEGLHRLSLLLRDSGQ 566
+G F+F L RLP + N++L + A + R + + ++ L +++ D G
Sbjct: 517 FANGPRFNFFLDERLP-VNPNFTLKDNEDNTASILTRRRRFSRTVQDVYYLPIMISDGGI 575
Query: 567 PPQQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLGALVIVLASALLLLVLVLLVAL 626
P L + VC C +DG A GLS GAL+ +L L+LL +V+L
Sbjct: 576 PSLSSSSTLTIRVCACERDGRVRTCHAEAFLSSAGLSTGALIAILLCVLILLAIVVLFIT 635
Query: 627 RARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHPTALSLPLGPPP 686
R K+ L ++D+R+NV+ YD++GGGEED +A+DI+ LR+P+A
Sbjct: 636 LRRSKKEP-----LIISEEDVRENVVTYDDEGGGEEDTEAFDITALRNPSAAE----ELK 686
Query: 687 LRRDA-PQGRLHPQPPRVLPTSPLDIADFINDGLEAADSDPSVPPYDTALIYDYEGDGSV 745
RRD P+ +L P+ +D+ +FI L AD DPSVPPYD+ Y YEG S
Sbjct: 687 YRRDIRPEVKLTPRHQTSSTLESIDVQEFIKQRLAEADLDPSVPPYDSLQTYAYEGQRSE 746
Query: 746 AGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMYG 781
AG++SS+ S+ DQDY YL DWGP F +LA++YG
Sbjct: 747 AGSISSLDSATTQSDQDYHYLGDWGPEFKKLAELYG 782
>gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens]
Length = 799
Score = 363 bits (933), Expect = e-100
Identities = 251/757 (33%), Positives = 397/757 (52%), Gaps = 38/757 (5%)
Query: 40 LSRVRRAWVIPPISVSENHKRLPYPLV--QIKSDKQQLGSVI-YSIQGPGVDEEPRGVFS 96
L+R +R WV + V E P P++ ++ +D I Y + G G +F
Sbjct: 56 LNRSKRGWVWNQMFVLEEFSG-PEPILVGRLHTDLDPGSKKIKYILSGDGAGT----IFQ 110
Query: 97 IDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGST-LEDPTDLEIVVVDQNDNRPAFLQE 155
I+ TG + LDRE+ + L A A+D S LE P++ I V D NDN P FL
Sbjct: 111 INDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNG 170
Query: 156 AFTGRVLEGAVPGTYVTRAEATDADDPETDNAA-LRFSILQQGSPELFSIDELTGEIRTV 214
+ V E ++ GT VT ATDADDP N+A L +SIL+ G P FSI+ T I+T
Sbjct: 171 PYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILE-GQP-YFSIEPETAIIKTA 228
Query: 215 QVGLDREVVAVYNLTLQVADMSGD--GLTATASAIITLDDINDNAPEFTRDEFFMEAIE- 271
+DRE Y + +Q DM G GL+ T + +TL D+NDN P+F + + E
Sbjct: 229 LPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPED 288
Query: 272 AVSGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYE 331
V G +GR++ D+D+ N + + I++GD F I +D + +G++ + K LD+E
Sbjct: 289 VVLGTAIGRVKANDQDI--GENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFE 346
Query: 332 SCEHYELKVSVQN-EAPLQAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPP 390
+ + Y LKV N + + + A V++ V+D +EPPVF + E A
Sbjct: 347 TKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAAL 406
Query: 391 GTLVATFSARDPD-TEQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWY 449
+++ +ARDPD T R S + D E ++A G+I + +P L W+
Sbjct: 407 NSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKIT---LATPLDRELSV-WH 462
Query: 450 RAIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGL-LLGATDE 508
++A + + + + ++I++L+VND+AP A LC G + + A D+
Sbjct: 463 NITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDK 522
Query: 509 DLPPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRH----QVPEGLHRLSLLLRDS 564
D P +G F + L P + N+++ + + + +H + + ++ L +++ DS
Sbjct: 523 DDPKNGHYFLYSLLPEMVN-NPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDS 581
Query: 565 GQPPQQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLGALVIVLASALLLLVLVLL- 623
G PP L + VC C DGV GLS+GAL+ +LA +LLLV+V+L
Sbjct: 582 GNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLF 641
Query: 624 VALRARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHPTALSLPLG 683
V LR + + + L+ +D+R+N++ YD++GGGEED +A+DI+ L++P ++ G
Sbjct: 642 VTLR-----RHKNEPLIIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGIN---G 693
Query: 684 PPPLRRDAPQGRLHPQPPRVLPTSPLDIADFINDGLEAADSDPSVPPYDTALIYDYEGDG 743
P + P + P+ + +D+ +FIN L AD+DP+ PPYD+ IY YEG G
Sbjct: 694 FLPRKDIKPDLQFMPRQGLAPVPNGVDVDEFINVRLHEADNDPTAPPYDSIQIYGYEGRG 753
Query: 744 SVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMY 780
SVAG+LSS+ S+ D DQ++DYL DWGPRF RL ++Y
Sbjct: 754 SVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGELY 790
>gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens]
Length = 788
Score = 362 bits (928), Expect = e-99
Identities = 258/777 (33%), Positives = 391/777 (50%), Gaps = 44/777 (5%)
Query: 22 VPGWRRPTTLYPWRRAPALSRVRRAWVIPPISVSENHKRLPYPLV-QIKSDKQQL-GSVI 79
VP R ++ P L R +R W+ + E + Y V ++ SD+ + GS+
Sbjct: 31 VPQQRILSSRVPRSDGKILHRQKRGWMWNQFFLLEEYTGSDYQYVGKLHSDQDKGDGSLK 90
Query: 80 YSIQGPGVDEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRLRAFALDLGG-STLEDPTDL 138
Y + G G +F ID+ TG + +DRE+ + LRA A++ +E ++
Sbjct: 91 YILSGDGAGT----LFIIDEKTGDIHATRRIDREEKAFYTLRAQAINRRTLRPVEPESEF 146
Query: 139 EIVVVDQNDNRPAFLQEAFTGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQGS 198
I + D NDN P F +E +T V E +V GT V + ATDADDP N+A + QG
Sbjct: 147 VIKIHDINDNEPTFPEEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSILQGQ 206
Query: 199 PELFSIDELTGEIRTVQVGLDREVVAVYNLTLQVADMSGD--GLTATASAIITLDDINDN 256
P FS++ TG IRT ++RE Y + +Q DM G GL+ T + ITL D+NDN
Sbjct: 207 P-YFSVEPETGIIRTALPNMNRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDN 265
Query: 257 APEFTRDEFFMEAIEAVS-GVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDP 315
P F ++ + +E+ G +G ++ D D N + I++GD F I T+
Sbjct: 266 PPRFPQNTIHLRVLESSPVGTAIGSVKATDADT--GKNAEVEYRIIDGDGTDMFDIVTEK 323
Query: 316 KTNEGVLSIVKALDYESCEHYELKVSVQN-EAPLQAAALRAERGQAKVRVHVQDTNEPPV 374
T EG++++ K LDYES Y LKV +N + L + V++ ++D +EPPV
Sbjct: 324 DTQEGIITVKKPLDYESRRLYTLKVEAENTHVDPRFYYLGPFKDTTIVKISIEDVDEPPV 383
Query: 375 FQENPLRTSLAEGAPPGTLVATFSARDPDTEQLQ-RLSYSKDYDPEDWLQVDAATGRIQT 433
F + + E GT++ T ARDPD+ R S + D + + + G + T
Sbjct: 384 FSRSSYLFEVHEDIEVGTIIGTVMARDPDSISSPIRFSLDRHTDLDRIFNIHSGNGSLYT 443
Query: 434 QHVLSPASPFLKGGWYRAIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCS 493
L W+ V+A + + T + + IL+VND+AP A +C
Sbjct: 444 SKPLDREL----SQWHNLTVIAAEINNPKETTRVAVFVRILDVNDNAPQFAVFYDTFVCE 499
Query: 494 EPHQGPGL-LLGATDEDLPPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPR----- 547
G + + A D+D P G F F L+ P N+++ + AR+ R
Sbjct: 500 NARPGQLIQTISAVDKDDPLGGQKFFFSLAAVNP----NFTVQDNEDNTARILTRKNGFN 555
Query: 548 -HQVPEGLHRLSLLLRDSGQPPQQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLGA 606
H++ L L +++ D+ P Q L + VC C G +A L GLS GA
Sbjct: 556 RHEISTYL--LPVVISDNDYPIQSSTGTLTIRVCACDSQGNMQSCSAEALLLPAGLSTGA 613
Query: 607 LVIVLASALLLLVLVLLVALRARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDA 666
L+ +L ++LLV+V+L A K+ R K L ++D+RDN+++Y+++GGGEED A
Sbjct: 614 LIAILLCIIILLVIVVLFAAL----KRQRKKEPLILSKEDIRDNIVSYNDEGGGEEDTQA 669
Query: 667 YDISQLRHPTALSLPLGPPPLRRDAPQGRLHPQPPRVLPTSP--LDIADFINDGLEAADS 724
+DI LR+P A+ LRRD L PR PT+P D+ DFIN+ L+ D
Sbjct: 670 FDIGTLRNPAAIE----EKKLRRDIIPETLFI--PRRTPTAPDNTDVRDFINERLKEHDL 723
Query: 725 DPSVPPYDTALIYDYEGDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMYG 781
DP+ PPYD+ Y YEG+ S+A +LSS+ S + DQ+YDYLR+WGPRF +LA+MYG
Sbjct: 724 DPTAPPYDSLATYAYEGNDSIAESLSSLESGTTEGDQNYDYLREWGPRFNKLAEMYG 780
>gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens]
Length = 801
Score = 360 bits (924), Expect = 3e-99
Identities = 255/760 (33%), Positives = 379/760 (49%), Gaps = 43/760 (5%)
Query: 42 RVRRAWVIPPISVSENHKRL-PYPLVQIKSDKQQL-GSVIYSIQGPGVDEEPRGVFSIDK 99
R +R+WV V E + P + ++ SD + GS+ Y + G G VF+ID
Sbjct: 56 RTKRSWVWNQFFVLEEYTGTDPLYVGKLHSDMDRGDGSIKYILSGEGAGI----VFTIDD 111
Query: 100 FTGKVFLNAMLDREKTDRFRLRAFALDLG-GSTLEDPTDLEIVVVDQNDNRPAFLQEAFT 158
TG + LDRE+ ++ LRA ALD G +E ++ I + D NDN P FL +
Sbjct: 112 TTGDIHAIQRLDREERAQYTLRAQALDRRTGRPMEPESEFIIKIQDINDNEPKFLDGPYV 171
Query: 159 GRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQGSPELFSIDELTGEIRTVQVGL 218
V E + GT V + ATDADDP N+A + QG P FS+D TG IRT + +
Sbjct: 172 ATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSILQGQP-YFSVDSKTGVIRTALMNM 230
Query: 219 DREVVAVYNLTLQVADMSGD--GLTATASAIITLDDINDNAPEFTRDEFFMEAIEAVS-G 275
DRE Y + +Q DM G GL T + ITL D+NDN P F + + M +E+
Sbjct: 231 DREAKEYYEVIIQAKDMGGQLGGLAGTTTVNITLSDVNDNPPRFPQKHYQMSVLESAPIS 290
Query: 276 VDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESCEH 335
VGR V +DL N ++TI++GD F I TDP G++++ K L +ES +
Sbjct: 291 STVGR--VFAKDLDEGINAEMKYTIVDGDGADAFDISTDPNFQVGIITVKKPLSFESKKS 348
Query: 336 YELKVSVQN-EAPLQAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGTLV 394
Y LKV N ++ L + V + V+D +EPPVF+ + E GT +
Sbjct: 349 YTLKVEGANPHLEMRFLNLGPFQDTTTVHISVEDVDEPPVFEPGFYFVEVPEDVAIGTTI 408
Query: 395 ATFSARDPD-TEQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYRAIV 453
SA+DPD T R S + DP + VD TG + T L + W+ V
Sbjct: 409 QIISAKDPDVTNNSIRYSIDRSSDPGRFFYVDITTGALMTARPLDRE----EFSWHNITV 464
Query: 454 LAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGL-LLGATDEDLPP 512
LA + + + + ++I++L+VND+AP +C G + + A D+D P
Sbjct: 465 LAMEMNNPSQVGSVPVTIKVLDVNDNAPEFPRFYEAFVCENAKAGQLIQTVSAVDQDDPR 524
Query: 513 HGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRH----QVPEGLHRLSLLLRDSGQPP 568
+G F++ L+P N+++ + AR+ R Q + + L +L+ DSGQP
Sbjct: 525 NGQHFYYSLAPEAAN-NPNFTIRDNQDNTARILTRRSGFRQQEQSVFHLPILIADSGQPV 583
Query: 569 QQREQPLNVTVCRCGKDG---VCLPGAAALLAGGTGLSLGALVIVLASALLLLVLVLLVA 625
L + VC C DG C P A L LS GAL+ +LA +LLVLVLL+
Sbjct: 584 LSSTGTLTIQVCSCDDDGHVMSCSPEAYML---PVSLSRGALIAILACIFVLLVLVLLIL 640
Query: 626 LRARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHPTALSLPLGPP 685
R KQ + ++++ +N++ YD++GGGEED +A+DI+ + +P P
Sbjct: 641 SMRRHRKQP----YIIDDEENIHENIVRYDDEGGGEEDTEAFDIAAMWNPREAQAGAAPK 696
Query: 686 PLRRDAPQ----GRLHPQPPRVLPTSPLDIADFINDGLEAADSDPSVPPYDTALIYDYEG 741
+ P+ R PQ V T + ++ L AD D PP+D+ Y +EG
Sbjct: 697 TRQDMLPEIESLSRYVPQTCAVNST----VHSYVLAKLYEADMDLWAPPFDSLQTYMFEG 752
Query: 742 DGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMYG 781
DGSVAG+LSS+ S+ D +Q +D+L DWGPRF +LA++YG
Sbjct: 753 DGSVAGSLSSLQSATSDSEQSFDFLTDWGPRFRKLAELYG 792
>gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo
sapiens]
Length = 847
Score = 351 bits (901), Expect = 1e-96
Identities = 229/633 (36%), Positives = 334/633 (52%), Gaps = 24/633 (3%)
Query: 40 LSRVRRAWVIPPISVSENHKRLPYPLV--QIKSDKQQLGSVIYSIQGPGVDEEPRGVFSI 97
L R +R W P S+ EN P+PL Q++SD Q ++ YSI+GPGVD+EPR +F +
Sbjct: 130 LRRAKRRWAPIPCSMLENSLG-PFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEPRNLFYV 188
Query: 98 DKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQEAF 157
++ TG ++ +DRE+ + F + AFA G T E P L I + D+NDN P F +E +
Sbjct: 189 ERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETY 248
Query: 158 TGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQ--GSPELFSIDELTGEIRTVQ 215
T + E GT V + ATD D+P+T + L++SI+ Q SP LFS+ TG I T
Sbjct: 249 TFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVITTTS 308
Query: 216 VGLDREVVAVYNLTLQVADMSGD--GLTATASAIITLDDINDNAPEFTRDEFFMEAIEAV 273
LDRE++ Y L ++V DM G GL T++ II +DD+ND+ P FTR + E
Sbjct: 309 SQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSVEENT 368
Query: 274 SGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESC 333
V++ R+ VED+DL + NW A +TIL+G+ +G F I TD KTNEGVL +VK L+YE
Sbjct: 369 VDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEEK 428
Query: 334 EHYELKVSVQNEAPL-QAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGT 392
+ L++ V NEAP + A+ R+ A V V+V+D +E P + E A GT
Sbjct: 429 QQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGT 488
Query: 393 LVATFSARDPDTEQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYRAI 452
+ A DP+T + Y K DP W+ +D TG I+ L + +K G Y
Sbjct: 489 TSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIYNIT 548
Query: 453 VLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGLLLGATDEDLPP 512
VLA D RT TGTL I + +VND++P + P +C ++ A D D P
Sbjct: 549 VLASDQGG--RTCTGTLGIILQDVNDNSPFI-PKKTVIICKPTMSSAEIV--AVDPDEPI 603
Query: 513 HGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRHQVPEGLHRLSLLLRDSGQPPQQRE 572
HG PF F L E+ R W L +N + ARL ++ P G + + + +RD +
Sbjct: 604 HGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRD--RLGMSSV 661
Query: 573 QPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLG---ALVIVLASALLLLVLVLLVALRAR 629
L+VT+C C + C + GG G+ LG L I+L ALL +L LV +
Sbjct: 662 TSLDVTLCDCITENDCTHRVDPRIGGG-GVQLGKWAILAILLGIALLFCILFTLVCGASG 720
Query: 630 FWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEE 662
KQ + P D + N++ + + G++
Sbjct: 721 TSKQPKVI-----PDDLAQQNLIVSNTEAPGDD 748
>gi|13435364 desmocollin 2 isoform Dsc2a preproprotein [Homo
sapiens]
Length = 901
Score = 351 bits (901), Expect = 1e-96
Identities = 229/633 (36%), Positives = 334/633 (52%), Gaps = 24/633 (3%)
Query: 40 LSRVRRAWVIPPISVSENHKRLPYPLV--QIKSDKQQLGSVIYSIQGPGVDEEPRGVFSI 97
L R +R W P S+ EN P+PL Q++SD Q ++ YSI+GPGVD+EPR +F +
Sbjct: 130 LRRAKRRWAPIPCSMLENSLG-PFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEPRNLFYV 188
Query: 98 DKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQEAF 157
++ TG ++ +DRE+ + F + AFA G T E P L I + D+NDN P F +E +
Sbjct: 189 ERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETY 248
Query: 158 TGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQ--GSPELFSIDELTGEIRTVQ 215
T + E GT V + ATD D+P+T + L++SI+ Q SP LFS+ TG I T
Sbjct: 249 TFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVITTTS 308
Query: 216 VGLDREVVAVYNLTLQVADMSGD--GLTATASAIITLDDINDNAPEFTRDEFFMEAIEAV 273
LDRE++ Y L ++V DM G GL T++ II +DD+ND+ P FTR + E
Sbjct: 309 SQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSVEENT 368
Query: 274 SGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESC 333
V++ R+ VED+DL + NW A +TIL+G+ +G F I TD KTNEGVL +VK L+YE
Sbjct: 369 VDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEEK 428
Query: 334 EHYELKVSVQNEAPL-QAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGT 392
+ L++ V NEAP + A+ R+ A V V+V+D +E P + E A GT
Sbjct: 429 QQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGT 488
Query: 393 LVATFSARDPDTEQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYRAI 452
+ A DP+T + Y K DP W+ +D TG I+ L + +K G Y
Sbjct: 489 TSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIYNIT 548
Query: 453 VLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGLLLGATDEDLPP 512
VLA D RT TGTL I + +VND++P + P +C ++ A D D P
Sbjct: 549 VLASDQGG--RTCTGTLGIILQDVNDNSPFI-PKKTVIICKPTMSSAEIV--AVDPDEPI 603
Query: 513 HGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRHQVPEGLHRLSLLLRDSGQPPQQRE 572
HG PF F L E+ R W L +N + ARL ++ P G + + + +RD +
Sbjct: 604 HGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRD--RLGMSSV 661
Query: 573 QPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLG---ALVIVLASALLLLVLVLLVALRAR 629
L+VT+C C + C + GG G+ LG L I+L ALL +L LV +
Sbjct: 662 TSLDVTLCDCITENDCTHRVDPRIGGG-GVQLGKWAILAILLGIALLFCILFTLVCGASG 720
Query: 630 FWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEE 662
KQ + P D + N++ + + G++
Sbjct: 721 TSKQPKVI-----PDDLAQQNLIVSNTEAPGDD 748
Score = 34.7 bits (78), Expect = 0.37
Identities = 18/47 (38%), Positives = 28/47 (59%), Gaps = 2/47 (4%)
Query: 732 DTALIYDYEGDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLAD 778
D L Y+YEG GSVAG++ S+ E+ ++L + P+F LA+
Sbjct: 852 DYVLTYNYEGRGSVAGSVG--CCSERQEEDGLEFLDNLEPKFRTLAE 896
>gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo
sapiens]
Length = 839
Score = 344 bits (883), Expect = 2e-94
Identities = 235/637 (36%), Positives = 334/637 (52%), Gaps = 29/637 (4%)
Query: 36 RAPALSRVRRAWVIPPISVSENHKRLPYPLV--QIKSDKQQLGSVIYSIQGPGVDEEPRG 93
R L R +R W P S+ EN P+PL Q++SD Q +V YSI G GVD+EP
Sbjct: 126 RETVLRRAKRRWAPIPCSMQENSLG-PFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLN 184
Query: 94 VFSIDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFL 153
+F I++ TG +F +DRE+ D F L A+A G + + P L I V D+NDN P F
Sbjct: 185 LFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFT 244
Query: 154 QEAFTGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQ--GSPELFSIDELTGEI 211
+ + VLE + PGT V ATD D+P+T + L++SILQQ SP LFS+ TG I
Sbjct: 245 EAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVI 304
Query: 212 RTVQVGLDREVVAVYNLTLQVADMSGD--GLTATASAIITLDDINDNAPEFTRDEFFMEA 269
TV LDREVV Y+L ++V DM G GL T++ IIT+ D NDNAP F ++ +
Sbjct: 305 TTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFV 364
Query: 270 IEAVSGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALD 329
E V++ R+ +ED+DL + NW FTIL+G+ +G F I TD +TNEGVLS+VK L+
Sbjct: 365 EENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLN 424
Query: 330 YESCEHYELKVSVQNEAPLQAAALRAER-GQAKVRVHVQDTNEPPVFQENPLRTSLAEGA 388
YE L++ V NEAP R +A V VHV+D +E P + E
Sbjct: 425 YEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENL 484
Query: 389 PPGTLVATFSARDPDTEQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGW 448
G+ + + A DP+ L Y K +DP+ W+ +D +G I T +L K
Sbjct: 485 AVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNEL 544
Query: 449 YRAIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGLLLGATDE 508
Y VLA D R+ TGTL++ I +VND+ P + + +P G +L A D
Sbjct: 545 YNITVLAID--KDDRSCTGTLAVNIEDVNDNPPEIL--QEYVVICKPKMGYTDIL-AVDP 599
Query: 509 DLPPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRHQVPEGLHRLSLLLRDSGQPP 568
D P HGAPF+F L PE+ R WSL++VN + ARL +Q G ++ + +
Sbjct: 600 DEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARL--SYQKNAGFQEYTIPITVKDRAG 657
Query: 569 QQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLG---ALVIVLASALLLLVLVLLVA 625
Q + L V +C C P + TG+ LG L I+L ALL VL+ LV
Sbjct: 658 QAATKLLRVNLCECTH-----PTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLV- 711
Query: 626 LRARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEE 662
+ ++GK P+D + N++ + + G++
Sbjct: 712 --CGVFGATKGKRF---PEDLAQQNLIISNTEAPGDD 743
>gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo
sapiens]
Length = 896
Score = 344 bits (883), Expect = 2e-94
Identities = 235/637 (36%), Positives = 334/637 (52%), Gaps = 29/637 (4%)
Query: 36 RAPALSRVRRAWVIPPISVSENHKRLPYPLV--QIKSDKQQLGSVIYSIQGPGVDEEPRG 93
R L R +R W P S+ EN P+PL Q++SD Q +V YSI G GVD+EP
Sbjct: 126 RETVLRRAKRRWAPIPCSMQENSLG-PFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLN 184
Query: 94 VFSIDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFL 153
+F I++ TG +F +DRE+ D F L A+A G + + P L I V D+NDN P F
Sbjct: 185 LFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFT 244
Query: 154 QEAFTGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQ--GSPELFSIDELTGEI 211
+ + VLE + PGT V ATD D+P+T + L++SILQQ SP LFS+ TG I
Sbjct: 245 EAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVI 304
Query: 212 RTVQVGLDREVVAVYNLTLQVADMSGD--GLTATASAIITLDDINDNAPEFTRDEFFMEA 269
TV LDREVV Y+L ++V DM G GL T++ IIT+ D NDNAP F ++ +
Sbjct: 305 TTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFV 364
Query: 270 IEAVSGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALD 329
E V++ R+ +ED+DL + NW FTIL+G+ +G F I TD +TNEGVLS+VK L+
Sbjct: 365 EENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLN 424
Query: 330 YESCEHYELKVSVQNEAPLQAAALRAER-GQAKVRVHVQDTNEPPVFQENPLRTSLAEGA 388
YE L++ V NEAP R +A V VHV+D +E P + E
Sbjct: 425 YEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENL 484
Query: 389 PPGTLVATFSARDPDTEQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGW 448
G+ + + A DP+ L Y K +DP+ W+ +D +G I T +L K
Sbjct: 485 AVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNEL 544
Query: 449 YRAIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGLLLGATDE 508
Y VLA D R+ TGTL++ I +VND+ P + + +P G +L A D
Sbjct: 545 YNITVLAID--KDDRSCTGTLAVNIEDVNDNPPEIL--QEYVVICKPKMGYTDIL-AVDP 599
Query: 509 DLPPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRHQVPEGLHRLSLLLRDSGQPP 568
D P HGAPF+F L PE+ R WSL++VN + ARL +Q G ++ + +
Sbjct: 600 DEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARL--SYQKNAGFQEYTIPITVKDRAG 657
Query: 569 QQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLG---ALVIVLASALLLLVLVLLVA 625
Q + L V +C C P + TG+ LG L I+L ALL VL+ LV
Sbjct: 658 QAATKLLRVNLCECTH-----PTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLV- 711
Query: 626 LRARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEE 662
+ ++GK P+D + N++ + + G++
Sbjct: 712 --CGVFGATKGKRF---PEDLAQQNLIISNTEAPGDD 743
Score = 37.4 bits (85), Expect = 0.056
Identities = 19/55 (34%), Positives = 31/55 (56%), Gaps = 2/55 (3%)
Query: 724 SDPSVPPYDTALIYDYEGDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLAD 778
++ +P D L Y+YEG GS AG++ S+ E+ D+L + P+F LA+
Sbjct: 839 NEDRMPSQDYVLTYNYEGRGSPAGSVG--CCSEKQEEDGLDFLNNLEPKFITLAE 891
>gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens]
Length = 789
Score = 344 bits (882), Expect = 2e-94
Identities = 252/759 (33%), Positives = 379/759 (49%), Gaps = 41/759 (5%)
Query: 40 LSRVRRAWVIPPISVSENHKRLPYPLV-QIKSDKQQL-GSVIYSIQGPGVDEEPRGVFSI 97
L R +R W+ + E + V ++ +D+ + G++ Y + G G +F I
Sbjct: 48 LRRTKRGWMWNQFFLLEEYTGTDTQYVGKLHTDQDKGDGNLKYILTGDGAGS----LFVI 103
Query: 98 DKFTGKVFLNAMLDREKTDRFRLRAFALDLG-GSTLEDPTDLEIVVVDQNDNRPAFLQEA 156
D+ TG + LDRE+ + LRA A+D G +E ++ I + D NDN P F ++
Sbjct: 104 DENTGDIHAAKKLDREEKSLYILRAKAIDRKTGRQVEPESEFIIKIHDINDNEPKFTKDL 163
Query: 157 FTGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQGSPELFSIDELTGEIRTVQV 216
+T V E + GT V + ATDADD N+A + QG P FS+D +G I+T
Sbjct: 164 YTASVPEMSGVGTSVIQVTATDADDANYGNSAKVVYSILQGQP-YFSVDPESGIIKTALP 222
Query: 217 GLDREVVAVYNLTLQVADMSGD--GLTATASAIITLDDINDNAPEFTRDEFFMEAIEAVS 274
+ RE Y + +Q DM G GL+ T + ITL D+N+N P F + + + E+V
Sbjct: 223 DMSRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNNNPPRFPQSTYQFNSPESVP 282
Query: 275 -GVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESC 333
G +GR++ D D+ N ++I EGD F + TD T EG++++ + LD+E+
Sbjct: 283 LGTHLGRIKANDPDV--GENAEMEYSIAEGDGADMFDVITDKDTQEGIITVKQNLDFENQ 340
Query: 334 EHYELKVSVQNEAP-LQAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGT 392
Y L+V N P + L + A V++ V+D +EPPVF + + E G+
Sbjct: 341 MLYTLRVDASNTHPDPRFLHLGPFKDTAVVKISVEDIDEPPVFTKVSYLIEVDEDVKEGS 400
Query: 393 LVATFSARDPDTEQ-LQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYRA 451
++ +A DPD L + S + D + + + G I T L S W+
Sbjct: 401 IIGQVTAYDPDARNNLIKYSVDRHTDMDRIFGIHSENGSIFTLKALDRES----SPWHNI 456
Query: 452 IVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGL-LLGATDEDL 510
V A + + +++ + I IL++NDHAP A +C G + + D+D
Sbjct: 457 TVTATEINNPKQSSHIPVFIRILDINDHAPEFAMYYETFVCENAKPGQLIQTVSVMDKDD 516
Query: 511 PPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRHQVPEGLHR-------LSLLLRD 563
PP G F F+ P L N+++ + A + R +G R L +L+ D
Sbjct: 517 PPRGHKFFFEPVPEFT-LNPNFTIVDNKDNTAGIMTRK---DGYSRNKMSTYLLPILIFD 572
Query: 564 SGQPPQQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLGALVIVLASALLLLVLVLL 623
+ P Q L + VC C G A L GLS GALV +L L+LL+LV+L
Sbjct: 573 NDYPIQSSTGTLTIRVCACDNQGNMQSCTAEALILSAGLSTGALVAILLCVLILLILVVL 632
Query: 624 VALRARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHPTALSLPLG 683
A K+ R K L +DD+RDN++ Y+++GGGEED A+DI LR+P A
Sbjct: 633 FAAL----KRQRKKEPLIISKDDVRDNIVTYNDEGGGEEDTQAFDIGTLRNPEARE---- 684
Query: 684 PPPLRRDAPQGRLHPQPPRVLPT-SPLDIADFINDGLEAADSDPSVPPYDTALIYDYEGD 742
LRRD + Q R +P +D+ DFI+ L+ D+DPS PPYD+ Y YEG+
Sbjct: 685 DSKLRRDVMPETIF-QIRRTVPLWENIDVQDFIHRRLKENDADPSAPPYDSLATYAYEGN 743
Query: 743 GSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMYG 781
S+A +LSS+ S D +QDYDYL DWGPRF +LADMYG
Sbjct: 744 DSIADSLSSLESLTADCNQDYDYLSDWGPRFKKLADMYG 782
>gi|32880203 cadherin-like 24 isoform 2 [Homo sapiens]
Length = 781
Score = 344 bits (882), Expect = 2e-94
Identities = 266/768 (34%), Positives = 382/768 (49%), Gaps = 54/768 (7%)
Query: 38 PALSRVRRAWVIPPISVSENHKRLPYPLV--QIKSDKQQ-LGSVIYSIQGPGVDEEPRGV 94
PAL R RR+WV V E + P P++ ++ SD + G Y + G G V
Sbjct: 37 PALLRTRRSWVWNQFFVIEEYAG-PEPVLIGKLHSDVDRGEGRTKYLLTGEGAGT----V 91
Query: 95 FSIDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGST-LEDPTDLEIVVVDQNDNRPAFL 153
F ID+ TG + + LDRE+ ++ L A A+D + LE P++ I V D NDN P F
Sbjct: 92 FVIDEATGNIHVTKSLDREEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPIFP 151
Query: 154 QEAFTGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQGSPELFSIDELTGEIRT 213
+ V E + GT V + A DADDP N+A + G P FS+D TG +RT
Sbjct: 152 LGPYHATVPEMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLDGLP-FFSVDPQTGVVRT 210
Query: 214 VQVGLDREVVAVYNLTLQVADMSGD--GLTATASAIITLDDINDNAPEFTRDEFFMEAIE 271
+DRE + + +Q DM G GL+ + + +TL D+NDN P+F + + +E
Sbjct: 211 AIPNMDRETQEEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVNDNPPKFPQSLYQFSVVE 270
Query: 272 AVS-GVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDY 330
G VGRL +D DL N + ++IL+G+ F+I TD + +G+L++ K LD+
Sbjct: 271 TAGPGTLVGRLRAQDPDL--GDNALMAYSILDGEGSEAFSISTDLQGRDGLLTVRKPLDF 328
Query: 331 ESCEHYELKVSVQNEAPLQAAALRAE--RGQAKVRVHVQDTNEPPVFQENPLRTSLAEGA 388
ES Y +V N + A LR + A VRV VQD EPP F + ++ E
Sbjct: 329 ESQRSYSFRVEATNTL-IDPAYLRRGPFKDVASVRVAVQDAPEPPAFTQAAYHLTVPENK 387
Query: 389 PPGTLVATFSARDPDTEQLQ-RLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGG 447
PGTLV SA D D+ R S DPE + G I T L +
Sbjct: 388 APGTLVGQISAADLDSPASPIRYSILPHSDPERCFSIQPEEGTIHTAAPLDREAR----A 443
Query: 448 WYRAIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGL-LLGAT 506
W+ VLA + S + + ++I+ L+ ND+AP LA P +C G + ++ A
Sbjct: 444 WHNLTVLATELDSSAQASRVQVAIQTLDENDNAPQLAEPYDTFVCDSAAPGQLIQVIRAL 503
Query: 507 DEDLPPHGAPFHFQLSPRLPELG------RNWSLSQVNVSHARLRPRHQVPEGLHRLSLL 560
D D + + FQ P P+ R+ S S + S PRH + + +
Sbjct: 504 DRDEVGNSSHVSFQ-GPLGPDANFTVQDNRDGSASLLLPSRPA-PPRHAP----YLVPIE 557
Query: 561 LRDSGQPPQQREQPLNVTVCRCGKDGV---CLPGAAALLAGGTGLSLGALV-IVLASALL 616
L D GQP + V+VCRC DG C P A AG LS GAL+ I+ L
Sbjct: 558 LWDWGQPALSSTATVTVSVCRCQPDGSVASCWPEAHLSAAG---LSTGALLAIITCVGAL 614
Query: 617 LLVLVLLVALRARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHPT 676
L ++VL VALR + + + L+ ++D+R+N++ YD++GGGEED +A+DI+ L++P
Sbjct: 615 LALVVLFVALR-----RQKQEALMVLEEEDVRENIITYDDEGGGEEDTEAFDITALQNPD 669
Query: 677 ALSLPLGPPPLRRDA-PQGRLHPQPPRVLPTSPLDIADFINDGLEAADSDPSVPPYDTAL 735
+ P PP RRD P+ R+ QP P P D+A + L AD DP VPPYD+
Sbjct: 670 GAAPPAPGPPARRDVLPRARVSRQP---RPPGPADVAQLLALRLREADEDPGVPPYDSVQ 726
Query: 736 IYDYEGDGSVAGTLSSILSSQ--GDEDQDYDYLRDWGPRFARLADMYG 781
+Y YEG GS G+LSS+ S G + L DWGP F LA++YG
Sbjct: 727 VYGYEGRGSSCGSLSSLGSGSEAGGAPGPAEPLDDWGPLFRTLAELYG 774
>gi|32880206 cadherin-like 24 isoform 1 [Homo sapiens]
Length = 819
Score = 331 bits (849), Expect = 1e-90
Identities = 266/801 (33%), Positives = 388/801 (48%), Gaps = 82/801 (10%)
Query: 38 PALSRVRRAWVIPPISVSENHKRLPYPLV--QIKSDKQQ-LGSVIYSIQGPGVDEEPRGV 94
PAL R RR+WV V E + P P++ ++ SD + G Y + G G V
Sbjct: 37 PALLRTRRSWVWNQFFVIEEYAG-PEPVLIGKLHSDVDRGEGRTKYLLTGEGAGT----V 91
Query: 95 FSIDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGST-LEDPTDLEIVVVDQNDNRPAFL 153
F ID+ TG + + LDRE+ ++ L A A+D + LE P++ I V D NDN P F
Sbjct: 92 FVIDEATGNIHVTKSLDREEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPIFP 151
Query: 154 QEAFTGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQGSPELFSIDELTGEIRT 213
+ V E + GT V + A DADDP N+A + G P FS+D TG +RT
Sbjct: 152 LGPYHATVPEMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLDGLP-FFSVDPQTGVVRT 210
Query: 214 VQVGLDREVVAVYNLTLQVADMSGD--GLTATASAIITLDDINDNAPEFTRDEFFMEAIE 271
+DRE + + +Q DM G GL+ + + +TL D+NDN P+F + + +E
Sbjct: 211 AIPNMDRETQEEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVNDNPPKFPQSLYQFSVVE 270
Query: 272 AVS-GVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDY 330
G VGRL +D DL N + ++IL+G+ F+I TD + +G+L++ K LD+
Sbjct: 271 TAGPGTLVGRLRAQDPDL--GDNALMAYSILDGEGSEAFSISTDLQGRDGLLTVRKPLDF 328
Query: 331 ESCEHYELKVSVQNEAPLQAAALRAE--RGQAKVRVHVQDTNEPPVFQENPLRTSLAEGA 388
ES Y +V N + A LR + A VRV VQD EPP F + ++ E
Sbjct: 329 ESQRSYSFRVEATNTL-IDPAYLRRGPFKDVASVRVAVQDAPEPPAFTQAAYHLTVPENK 387
Query: 389 PPGTLVATFSARDPDTEQLQ-RLSYSKDYDPEDWLQVDAATGRIQTQHVL---------- 437
PGTLV SA D D+ R S DPE + G I T L
Sbjct: 388 APGTLVGQISAADLDSPASPIRYSILPHSDPERCFSIQPEEGTIHTAAPLDREARAWHNL 447
Query: 438 --------------------------SPASPFLKGGWYRAIVLAQDDASQPRTATGTLSI 471
+PA+P + A+ + QD ++Q + ++I
Sbjct: 448 TVLATELGWSWGPERGWVPLLVAEWSAPAAPPQRSPVGSAVGIPQDSSAQ--ASRVQVAI 505
Query: 472 EILEVNDHAPVLAPPPPGSLCSEPHQGPGL-LLGATDEDLPPHGAPFHFQLSPRLPELGR 530
+ L+ ND+AP LA P +C G + ++ A D D + + FQ P P+
Sbjct: 506 QTLDENDNAPQLAEPYDTFVCDSAAPGQLIQVIRALDRDEVGNSSHVSFQ-GPLGPD--A 562
Query: 531 NWSL-SQVNVSHARLRPRHQVP--EGLHRLSLLLRDSGQPPQQREQPLNVTVCRCGKDG- 586
N+++ + S + L P P + + + L D GQP + V+VCRC DG
Sbjct: 563 NFTVQDNRDGSASLLLPSRPAPPRHAPYLVPIELWDWGQPALSSTATVTVSVCRCQPDGS 622
Query: 587 --VCLPGAAALLAGGTGLSLGALV-IVLASALLLLVLVLLVALRARFWKQSRGKGLLHGP 643
C P A A GLS GAL+ I+ LL ++VL VALR + + + L+
Sbjct: 623 VASCWPEAHLSAA---GLSTGALLAIITCVGALLALVVLFVALR-----RQKQEALMVLE 674
Query: 644 QDDLRDNVLNYDEQGGGEEDQDAYDISQLRHPTALSLPLGPPPLRRDA-PQGRLHPQPPR 702
++D+R+N++ YD++GGGEED +A+DI+ L++P + P PP RRD P+ R+ QP
Sbjct: 675 EEDVRENIITYDDEGGGEEDTEAFDITALQNPDGAAPPAPGPPARRDVLPRARVSRQP-- 732
Query: 703 VLPTSPLDIADFINDGLEAADSDPSVPPYDTALIYDYEGDGSVAGTLSSILSSQ--GDED 760
P P D+A + L AD DP VPPYD+ +Y YEG GS G+LSS+ S G
Sbjct: 733 -RPPGPADVAQLLALRLREADEDPGVPPYDSVQVYGYEGRGSSCGSLSSLGSGSEAGGAP 791
Query: 761 QDYDYLRDWGPRFARLADMYG 781
+ L DWGP F LA++YG
Sbjct: 792 GPAEPLDDWGPLFRTLAELYG 812
>gi|166362713 cadherin 5, type 2 preproprotein [Homo sapiens]
Length = 784
Score = 328 bits (842), Expect = 9e-90
Identities = 262/799 (32%), Positives = 387/799 (48%), Gaps = 64/799 (8%)
Query: 9 LGLLAQSLCLSLGV-PGWRRPTTLYPWRRAPALSRVRRAWVIPPISVSEN-HKRLPYPLV 66
LGLLA + + G P R +L P R R +R W+ + + E + LP+ +
Sbjct: 15 LGLLAVAAVAAAGANPAQRDTHSLLPTHR-----RQKRDWIWNQMHIDEEKNTSLPHHVG 69
Query: 67 QIKSDKQQLGSVIYSIQGPGVDEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRLRAFALD 126
+IKS + + Y ++G V + VF +D TG VF LDRE + L A +D
Sbjct: 70 KIKSSVSRKNAK-YLLKGEYVGK----VFRVDAETGDVFAIERLDRENISEYHLTAVIVD 124
Query: 127 LG-GSTLEDPTDLEIVVVDQNDNRPAFLQEAFTGRVLEGAVPGTYVTRAEATDADDPET- 184
G LE P+ I V D NDN P F F V E + GT V A DADDP
Sbjct: 125 KDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVG 184
Query: 185 DNAALRFSILQQGSPELFSIDELTGEIRTVQVGLDREVVAVYNLTLQVADMSG-DGLTAT 243
D+A++ + IL+ E F+ID +G I T+ LDRE A Y + ++ D G G + T
Sbjct: 185 DHASVMYQILK--GKEYFAIDN-SGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGT 241
Query: 244 ASAIITLDDINDNAPEFTRDEF-FMEAIEAVSGVDVGRLEVEDRDLPGSPNWVARFTILE 302
A+ ++TL DINDN P FT+ ++ F+ + G VG L VED D P N + +++IL
Sbjct: 242 ATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEP--QNRMTKYSILR 299
Query: 303 GDPDGQFTIRTDPKTNEGVLSIVKALDYESCEHYELKVSVQNEAPLQAAALRAERGQAKV 362
GD FTI T+P NEG++ +K LDYE + Y V + +A+V
Sbjct: 300 GDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQV 359
Query: 363 RVHVQDTNEPPVFQENPLRTSLAEGAPPGTLVATFSARDPDTEQLQRLSYS--KDYDPED 420
+++ D +EPP+FQ+ L E L+ T A DPD + + YS + D
Sbjct: 360 IINITDVDEPPIFQQPFYHFQLKENQKK-PLIGTVLAMDPDAAR-HSIGYSIRRTSDKGQ 417
Query: 421 WLQVDAATGRIQTQHVLSPASPFLKGGWYRAIVLAQDDASQPRTATGTLSI-----EILE 475
+ +V + + P WY V A++ T TG SI E+L+
Sbjct: 418 FFRVTKKGDIYNEKELDREVYP-----WYNLTVEAKE-LDSTGTPTGKESIVQVHIEVLD 471
Query: 476 VNDHAPVLAPPPPGSLCSEPHQGPGLL-LGATDEDLPPHGAPFHFQLSPRLPELGRNWSL 534
ND+AP A P +C G +L + A D+D+ P F F L+ N++L
Sbjct: 472 ENDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFILNTE-----NNFTL 526
Query: 535 SQVNVSHARLRPRH----QVPEGLHRLSLLLRDSGQPPQQREQPLNVTVCRCGKDGVCLP 590
+ + + A + ++ + +H L +++ D+G P + L V VC+C + G
Sbjct: 527 TDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFT- 585
Query: 591 GAAALLAGGTGLSLGALVIVLASALLLLVLVLLVALRARFWKQSRGKGLLHGPQDDLRDN 650
+A G+S+ A+V +L L + V+ LL+ LR R KQ+R G ++ +
Sbjct: 586 -FCEDMAAQVGVSIQAVVAILLCILTITVITLLIFLRRRLRKQARAHGK---SVPEIHEQ 641
Query: 651 VLNYDEQGGGEEDQDAYDISQLRHPTALSLPLGPPPLRRDAPQGR--LHPQ---PPRVLP 705
++ YDE+GGGE D +YD+S L S+ G R A R L+ Q PPR P
Sbjct: 642 LVTYDEEGGGEMDTTSYDVSVLN-----SVRRGGAKPPRPALDARPSLYAQVQKPPRHAP 696
Query: 706 TS---PLDIADFINDGLEAADSDPSVPPYDTALIYDYEGDGSVAGTLSSILSSQGDEDQD 762
+ P ++A I + AD D PPYDT IY YEG S+A +LSS+ + D D D
Sbjct: 697 GAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVD 756
Query: 763 YDYLRDWGPRFARLADMYG 781
YD+L DWGPRF LA++YG
Sbjct: 757 YDFLNDWGPRFKMLAELYG 775
>gi|16753221 cadherin 22 precursor [Homo sapiens]
Length = 828
Score = 328 bits (842), Expect = 9e-90
Identities = 259/816 (31%), Positives = 379/816 (46%), Gaps = 69/816 (8%)
Query: 8 VLGLLAQSLCLSLGVPGWRRPTTLYPWRRAPALSRVRRAWVIPPISVSENHKRL-PYPLV 66
+LG L + S PG R+ L RV+R WV V E + P +
Sbjct: 32 LLGRLWAAGTPSPSAPGARQDGAL-------GAGRVKRGWVWNQFFVVEEYTGTEPLYVG 84
Query: 67 QIKSDKQQL-GSVIYSIQGPGVDEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRLRAFAL 125
+I SD + G++ Y+I G G +F ID+ TG + LDRE+ + LRA A
Sbjct: 85 KIHSDSDEGDGAIKYTISGEGAGT----IFLIDELTGDIHAMERLDREQKTFYTLRAQAR 140
Query: 126 DLGGSTLEDP-TDLEIVVVDQNDNRPAFLQEAFTGRVLEGAVPGTYVTRAEATDADDPET 184
D + L +P ++ I V D ND+ P FL + G V E + GT V + A+DADDP
Sbjct: 141 DRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTY 200
Query: 185 DNAA-LRFSILQQGSPELFSIDELTGEIRTVQVGLDREVVAVYNLTLQVADMSGD--GLT 241
++A L +S+L F++D TG IRT LDRE Y + +Q DM+G GL+
Sbjct: 201 GSSARLVYSVLD--GEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLS 258
Query: 242 ATASAIITLDDINDNAPEFTRDEFFMEAIEAVS-GVDVGRLEVEDRDLPGSPNWVARFTI 300
+ + I + D+NDN P F + + E+ G VGR++ ED D+ + +
Sbjct: 259 GSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKD 318
Query: 301 LEGDPDGQFTIRTDPKTNEGVLSIVKALDYESCEHYELKVSVQNE-APLQAAALRAERGQ 359
F + TD T E ++ + K LD+ES + + + N+ + A L R Q
Sbjct: 319 ESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQ 378
Query: 360 AKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGTLVATFSARDPDTEQLQ-RLSYSKDYDP 418
A VRV V D +EPP F+ + E A G+LV +ARDPD R + ++ D
Sbjct: 379 AIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRESDL 438
Query: 419 EDWLQVDAATGRIQTQHVLSPASPFLKGGWYRAIVLAQDDASQPRTATGTLSIEILEVND 478
+ +DA TG I T L + GW+ VLA + + + + +L I IL+VND
Sbjct: 439 DQIFDIDADTGAIVTGKGLDRET----AGWHNITVLAMEADNHAQLSRASLRIRILDVND 494
Query: 479 HAPVLAPPPPGSLCSEPHQGPGL-LLGATDEDLPPHGAPFHFQLSPRLPELGRNWSLSQV 537
+ P LA P ++C + G + + D D P G F+F+L P P ++SL +
Sbjct: 495 NPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPS-NPHFSLLDI 553
Query: 538 NVSHARLRPRH----QVPEGLHRLSLLLRDSGQPPQQREQPLNVTVCRCGKDGVCLPGAA 593
+ A + +H + + + L +L+ DSG P L + +C C G
Sbjct: 554 QDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRICGCDSSGTIQSCNT 613
Query: 594 ALLAGGTGLSLGALVIVLASALLLLVLVLLVALRARFWKQSRGKGLLHGPQDDLRDNVLN 653
LS GAL+ +L L+L+VLVLL+ R K L +D+RDNV+
Sbjct: 614 TAFVMAASLSPGALIALLVCVLILVVLVLLILTLRRHHKSH----LSSDEDEDMRDNVIK 669
Query: 654 YDEQGGGEEDQDAYDISQLRHPTALSL--------------------PLGPPPL------ 687
Y+++GGGE+D +AYD+S LR G PP
Sbjct: 670 YNDEGGGEQDTEAYDMSALRSLYDFGELKGGDGGGSAGGGAGGGSGGGAGSPPQAHLPSE 729
Query: 688 RRDAPQGRLHPQPPRVLPTSPLDIADFINDGLEAADSDPSVPPYDTALIYDYEGDGSVAG 747
R PQG P+P + DFI+ + AD D SVPPYD Y +EG S A
Sbjct: 730 RHSLPQGPPSPEPDFSV------FRDFISRKVALADGDLSVPPYDAFQTYAFEGADSPAA 783
Query: 748 TLSSILSSQGDEDQDYDYLRDWGPRFARLADMY-GH 782
+LSS+ S +QD+ YL WGPRF LA +Y GH
Sbjct: 784 SLSSLHSGSSGSEQDFAYLSSWGPRFRPLAALYAGH 819
>gi|29789445 desmoglein 4 isoform 2 [Homo sapiens]
Length = 1040
Score = 301 bits (771), Expect = 2e-81
Identities = 231/815 (28%), Positives = 381/815 (46%), Gaps = 91/815 (11%)
Query: 42 RVRRAWVIPPISVSE---NHKRLPYPLVQIKSDKQQLGSVIYSIQGPGVDEEPRGVFSID 98
R +R W+ + E N KR P+ +I+SD + + Y I G G+D P GVF+I+
Sbjct: 46 RQKREWIKFAAACREGEDNSKR--NPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTIN 103
Query: 99 KFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQEAFT 158
TG++ + +++DRE T F + AL+ G LE P +L + V+D NDN P F Q +T
Sbjct: 104 PRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYT 163
Query: 159 GRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQ---GSPELFSIDELTGEIRTVQ 215
+ E + T V + ATDAD+ N+ + + I+ Q G+P +F ++ TGE+ T+
Sbjct: 164 ASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAP-MFILNRYTGEVCTMS 222
Query: 216 VGLDREVVAVYNLTLQVADMSG--DGLTATASAIITLDDINDNAPEFTRDEFFMEAIEAV 273
LDRE ++YNL ++ +D G DGL++ I + D+NDN P + + E
Sbjct: 223 SFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENC 282
Query: 274 SGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESC 333
++ RL+ D D G+ NW+A++ IL G+ F I+TDP+TNEG+L +VK LDYE
Sbjct: 283 LSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQA 342
Query: 334 EHYELKVSVQNEAPLQ-AAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGT 392
+ +L + V+N+A + A + + VR+ V D E P F + + S+ EG +
Sbjct: 343 PNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSS 402
Query: 393 L----VATFSARDPDT-EQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGG 447
L + T++A D DT + Y +D WL++D+ TG IQ S ++ G
Sbjct: 403 LLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIING 462
Query: 448 WYRAIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGLLLGATD 507
Y A +LA DD S +TATGT+ IE+ ++ND+ P + P ++C + P +L+ +
Sbjct: 463 IYTAEILAIDDGS-GKTATGTICIEVPDINDYCPNIF-PERRTICID---SPSVLISVNE 517
Query: 508 EDLPPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRHQVPEGLHRLSLLLRDSGQP 567
+G+PF F + P + W + N + A L + + G + + +L++DS
Sbjct: 518 HS---YGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPILVKDSYNR 574
Query: 568 PQQREQPLNVTVCRCGKDGVCLPGAAALL-----------------AGGTGLSLG--ALV 608
+ Q + + C C + +CL AA + AG + + LG +
Sbjct: 575 ACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIG 634
Query: 609 IVLASALLLLVLVLLVALRARFWKQSRGKGLLHGPQDDLRDNVL-NYDEQGGGEEDQDAY 667
+++ LLL++ LL+ L +Q G G P + + V+ ++ +G ED+D
Sbjct: 635 MMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGEGVMQSWRIEGAHPEDRDVS 694
Query: 668 DI---------------------------------SQLRHPTALSLPLG----------P 684
+I S + T + +G
Sbjct: 695 NICAPMTASNTQDRMDSSEIYTNTYAAGGTVEGGVSGVELNTGMGTAVGLMAAGAAGASG 754
Query: 685 PPLRRDAPQGRLHPQPPRVLPTSPLDIADFINDGLEAADSDPSVPPYDTALIYDYEGDGS 744
+R + G L + + LD + F AD D P D LIYD+EG GS
Sbjct: 755 AARKRSSTMGTLRDYADADINMAFLD-SYFSEKAYAYADEDEGRPANDCLLIYDHEGVGS 813
Query: 745 VAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADM 779
G++ S +D D + P+F LA++
Sbjct: 814 PVGSIG--CCSWIVDDLDESCMETLDPKFRTLAEI 846
>gi|12656655 cadherin 19, type 2 preproprotein [Homo sapiens]
Length = 772
Score = 301 bits (770), Expect = 2e-81
Identities = 231/753 (30%), Positives = 355/753 (47%), Gaps = 40/753 (5%)
Query: 42 RVRRAWVIPPISVSENHKRLPYPLVQIKSDKQQ-LGSVIYSIQGPGVDEEPRGVFSIDKF 100
RV+R WV V E + + Q++SD S Y + G G F ID+
Sbjct: 40 RVKRGWVWNQFFVPEEMNTTSHHIGQLRSDLDNGNNSFQYKLLGAGAGS----TFIIDER 95
Query: 101 TGKVFLNAMLDREKTDRFRLRAFALDLG-GSTLEDPTDLEIVVVDQNDNRPAFLQEAFTG 159
TG ++ LDRE+ + LRA +D+ G +E ++ I V D NDN P FL E +
Sbjct: 96 TGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEA 155
Query: 160 RVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQGSPELFSIDELTGEIRTVQVGLD 219
V E + GT V + A+DADDP + N A L QG P FS++ TG IR + +D
Sbjct: 156 IVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQP-YFSVEPTTGVIR-ISSKMD 213
Query: 220 REVVAVYNLTLQVADMSGD--GLTATASAIITLDDINDNAPEFTRDEFFMEAIE-AVSGV 276
RE+ Y + +Q DM G L+ T S +I L D+NDN P F + + E A +G
Sbjct: 214 RELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGT 273
Query: 277 DVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESCEHY 336
+G + D D+ N ++I E D F I T+ +T EG++ + K +D+E HY
Sbjct: 274 SIGTIMAYDNDI--GENAEMDYSIEEDDSQ-TFDIITNHETQEGIVILKKKVDFEHQNHY 330
Query: 337 ELKVSVQNE-APLQAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGTLVA 395
++ V+N P Q E +++ V+D +EPP+F + E P G+ V
Sbjct: 331 GIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVG 390
Query: 396 TFSARDPDTEQLQ---RLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYRAI 452
SA DPD + ++ SK ++ D G I T + L WY
Sbjct: 391 VVSATDPDNRKSPIRYSITRSKVFNIND-------NGTITTSNSLDREI----SAWYNLS 439
Query: 453 VLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGL-LLGATDEDLP 511
+ A + + + ++ L +++L +NDHAP + +C G + + A D D
Sbjct: 440 ITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDRDES 499
Query: 512 PHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPR---HQVPEGLHRLSLLLRDSGQPP 568
F+F LS + + + L R + E + +S+L+ D+G P
Sbjct: 500 IEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPS 559
Query: 569 QQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLGALVIVLASALLLLVLVLLVALRA 628
L + VC CG G L LS+G V+ + L+ ++++
Sbjct: 560 LTSTNTLTIHVCDCGDSGSTQTCQYQELV----LSMGFKTEVIIAILICIMIIFGFIFLT 615
Query: 629 RFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHPTALSLPLGPPPLR 688
KQ R + L +D R+N+ YD++GGGEED +A+DI++LR T +
Sbjct: 616 LGLKQRRKQILFPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRER--KTRKT 673
Query: 689 RDAPQGRLHPQPPRVLPTSPLDIADFINDGLEAADSDPSVPPYDTALIYDYEGDGSVAGT 748
A L+ Q +V P S + FI + LE A++DP PP+D+ Y +EG GS+AG+
Sbjct: 674 TSAEIRSLYRQSLQVGPDSAI-FRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGS 732
Query: 749 LSSILSSQGDEDQDYDYLRDWGPRFARLADMYG 781
LSS+ S+ D+D+ YDYL + GPRF RLA M+G
Sbjct: 733 LSSLESAVSDQDESYDYLNELGPRFKRLACMFG 765
>gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens]
Length = 840
Score = 297 bits (760), Expect = 3e-80
Identities = 217/639 (33%), Positives = 314/639 (49%), Gaps = 29/639 (4%)
Query: 39 ALSRVRRAWVIPPISVSENHKRLPYP--LVQIKSDKQQLGSVIYSIQGPGVDEEPRGVFS 96
AL R +R W P S+ EN P+P + QI+SD Q ++ YSI GPGVD+EP +F
Sbjct: 128 ALKRSKRRWAPIPASLMENSLG-PFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFNLFY 186
Query: 97 IDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQEA 156
I+K TG +F +DREK ++F L +A G E P L I + D NDN P F
Sbjct: 187 IEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFEHRV 246
Query: 157 FTGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQ--GSPELFSIDELTGEIRTV 214
V E GT V + ATD D+P+T + L++ ILQQ P+ FSI TG I T
Sbjct: 247 TIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDTGVITTT 306
Query: 215 QVGLDREVVAVYNLTLQVADMSGD--GLTATASAIITLDDINDNAPEFTRDEFFMEAIEA 272
LDRE Y L ++V DM G GL T + I+L+D NDN P FT + E E
Sbjct: 307 TPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEEN 366
Query: 273 VSGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYES 332
V++ R++V+D+DLP +P+ A + IL+G+ +G F I TDP TNEGVL +VK L+YE
Sbjct: 367 RIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYEV 426
Query: 333 CEHYELKVSVQNEAPLQAAALRAERGQ--AKVRVHVQDTNEPPVFQENPLRTSLAEGAPP 390
L+V V NEA AA V V + D++E P +G P
Sbjct: 427 NRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPA 486
Query: 391 GTLVATFSARDPDTEQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYR 450
G + + A DP+ + L Y K D ++W +++ TG ++T VL S F+K Y
Sbjct: 487 GQELLGYKALDPEISSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNNQYN 546
Query: 451 AIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGLLLGATDEDL 510
V+A D R+ TGTL + + + NDHAP + ++C + +L D D
Sbjct: 547 ISVVAVDAVG--RSCTGTLVVHLDDYNDHAPQI--DKEVTICQ--NNEDFAVLKPVDPDG 600
Query: 511 PPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRHQVPEGLHRLSLLLRDSGQPPQQ 570
P +G PF F L +NW++ + + A LR R + + + + ++D +
Sbjct: 601 PENGPPFQFFLD---NSASKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKD--RHGLV 655
Query: 571 REQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLG---ALVIVLASALLLLVLVLLVALR 627
L V VC C C + + LG L +VL S LLL +L +
Sbjct: 656 ATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCILFTCFCVT 715
Query: 628 ARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDA 666
A K++ K P+D + N++ + +G GEE +A
Sbjct: 716 A---KRTVKKCF---PEDIAQQNLIVSNTEGPGEEVTEA 748
>gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo
sapiens]
Length = 894
Score = 297 bits (760), Expect = 3e-80
Identities = 217/639 (33%), Positives = 314/639 (49%), Gaps = 29/639 (4%)
Query: 39 ALSRVRRAWVIPPISVSENHKRLPYP--LVQIKSDKQQLGSVIYSIQGPGVDEEPRGVFS 96
AL R +R W P S+ EN P+P + QI+SD Q ++ YSI GPGVD+EP +F
Sbjct: 128 ALKRSKRRWAPIPASLMENSLG-PFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFNLFY 186
Query: 97 IDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQEA 156
I+K TG +F +DREK ++F L +A G E P L I + D NDN P F
Sbjct: 187 IEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFEHRV 246
Query: 157 FTGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQ--GSPELFSIDELTGEIRTV 214
V E GT V + ATD D+P+T + L++ ILQQ P+ FSI TG I T
Sbjct: 247 TIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDTGVITTT 306
Query: 215 QVGLDREVVAVYNLTLQVADMSGD--GLTATASAIITLDDINDNAPEFTRDEFFMEAIEA 272
LDRE Y L ++V DM G GL T + I+L+D NDN P FT + E E
Sbjct: 307 TPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEEN 366
Query: 273 VSGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYES 332
V++ R++V+D+DLP +P+ A + IL+G+ +G F I TDP TNEGVL +VK L+YE
Sbjct: 367 RIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYEV 426
Query: 333 CEHYELKVSVQNEAPLQAAALRAERGQ--AKVRVHVQDTNEPPVFQENPLRTSLAEGAPP 390
L+V V NEA AA V V + D++E P +G P
Sbjct: 427 NRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPA 486
Query: 391 GTLVATFSARDPDTEQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYR 450
G + + A DP+ + L Y K D ++W +++ TG ++T VL S F+K Y
Sbjct: 487 GQELLGYKALDPEISSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNNQYN 546
Query: 451 AIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGLLLGATDEDL 510
V+A D R+ TGTL + + + NDHAP + ++C + +L D D
Sbjct: 547 ISVVAVDAVG--RSCTGTLVVHLDDYNDHAPQI--DKEVTICQ--NNEDFAVLKPVDPDG 600
Query: 511 PPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRHQVPEGLHRLSLLLRDSGQPPQQ 570
P +G PF F L +NW++ + + A LR R + + + + ++D +
Sbjct: 601 PENGPPFQFFLD---NSASKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKD--RHGLV 655
Query: 571 REQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLG---ALVIVLASALLLLVLVLLVALR 627
L V VC C C + + LG L +VL S LLL +L +
Sbjct: 656 ATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCILFTCFCVT 715
Query: 628 ARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDA 666
A K++ K P+D + N++ + +G GEE +A
Sbjct: 716 A---KRTVKKCF---PEDIAQQNLIVSNTEGPGEEVTEA 748
Score = 30.0 bits (66), Expect = 9.0
Identities = 16/46 (34%), Positives = 25/46 (54%), Gaps = 2/46 (4%)
Query: 732 DTALIYDYEGDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLA 777
D Y+YEG GS+AG++ S E++ ++L P+F LA
Sbjct: 845 DYVCSYNYEGKGSLAGSVG--CCSDRQEEEGLEFLDHLEPKFRTLA 888
>gi|197313787 desmoglein 4 isoform 1 [Homo sapiens]
Length = 1059
Score = 291 bits (746), Expect = 1e-78
Identities = 199/657 (30%), Positives = 332/657 (50%), Gaps = 45/657 (6%)
Query: 42 RVRRAWVIPPISVSE---NHKRLPYPLVQIKSDKQQLGSVIYSIQGPGVDEEPRGVFSID 98
R +R W+ + E N KR P+ +I+SD + + Y I G G+D P GVF+I+
Sbjct: 46 RQKREWIKFAAACREGEDNSKR--NPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTIN 103
Query: 99 KFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQEAFT 158
TG++ + +++DRE T F + AL+ G LE P +L + V+D NDN P F Q +T
Sbjct: 104 PRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYT 163
Query: 159 GRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQ---GSPELFSIDELTGEIRTVQ 215
+ E + T V + ATDAD+ N+ + + I+ Q G+P +F ++ TGE+ T+
Sbjct: 164 ASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAP-MFILNRYTGEVCTMS 222
Query: 216 VGLDREVVAVYNLTLQVADMSG--DGLTATASAIITLDDINDNAPEFTRDEFFMEAIEAV 273
LDRE ++YNL ++ +D G DGL++ I + D+NDN P + + E
Sbjct: 223 SFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENC 282
Query: 274 SGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESC 333
++ RL+ D D G+ NW+A++ IL G+ F I+TDP+TNEG+L +VK LDYE
Sbjct: 283 LSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQA 342
Query: 334 EHYELKVSVQNEAPLQ-AAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGT 392
+ +L + V+N+A + A + + VR+ V D E P F + + S+ EG +
Sbjct: 343 PNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSS 402
Query: 393 L----VATFSARDPDT-EQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGG 447
L + T++A D DT + Y +D WL++D+ TG IQ S ++ G
Sbjct: 403 LLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIING 462
Query: 448 WYRAIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGLLLGATD 507
Y A +LA DD S +TATGT+ IE+ ++ND+ P + P ++C + P +L+ +
Sbjct: 463 IYTAEILAIDDGS-GKTATGTICIEVPDINDYCPNIF-PERRTICID---SPSVLISVNE 517
Query: 508 EDLPPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRHQVPEGLHRLSLLLRDSGQP 567
+G+PF F + P + W + N + A L + + G + + +L++DS
Sbjct: 518 HS---YGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPILVKDSYNR 574
Query: 568 PQQREQPLNVTVCRCGKDGVCLPGAAALL-----------------AGGTGLSLG--ALV 608
+ Q + + C C + +CL AA + AG + + LG +
Sbjct: 575 ACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIG 634
Query: 609 IVLASALLLLVLVLLVALRARFWKQSRGKGLLHGPQDDLRDNVL-NYDEQGGGEEDQ 664
+++ LLL++ LL+ L +Q G G P + + V+ ++ +G ED+
Sbjct: 635 MMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGEGVMQSWRIEGAHPEDR 691
Score = 34.7 bits (78), Expect = 0.37
Identities = 21/58 (36%), Positives = 29/58 (50%), Gaps = 2/58 (3%)
Query: 722 ADSDPSVPPYDTALIYDYEGDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADM 779
AD D P D LIYD+EG GS G++ S +D D + P+F LA++
Sbjct: 810 ADEDEGRPANDCLLIYDHEGVGSPVGSIG--CCSWIVDDLDESCMETLDPKFRTLAEI 865
>gi|116534898 desmoglein 2 preproprotein [Homo sapiens]
Length = 1118
Score = 278 bits (711), Expect = 1e-74
Identities = 203/673 (30%), Positives = 331/673 (49%), Gaps = 27/673 (4%)
Query: 4 AFLLVLGLLAQSLCLSLGVPGWRRPTTLYPWRRAPALSRVRRAWVIPPISVSENHK-RLP 62
A LL+L L L V R L P + P L R +RAW+ P+++ E
Sbjct: 10 ALLLLLICFNVGSGLHLQVLSTRNENKLLP--KHPHLVRQKRAWITAPVALREGEDLSKK 67
Query: 63 YPLVQIKSD--KQQLGSVIYSIQGPGVDEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRL 120
P+ +I SD +++ + Y G G+ E P G+F +K TG++ + ++LDRE+T F L
Sbjct: 68 NPIAKIHSDLAEERGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSILDREETPFFLL 127
Query: 121 RAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQEAFTGRVLEGAVPGTYVTRAEATDAD 180
+ALD G+ +E P +L I V+D NDN P F Q+ F G V E + T V + ATDAD
Sbjct: 128 TGYALDARGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDAD 187
Query: 181 DPETDNAALRFSI--LQQGSPELFSIDELTGEIRTVQVGLDREVVAVYNLTLQVADMSG- 237
+P T N+ + + I L+ P +F +++ TGEI T V LDRE + Y LT++ D +G
Sbjct: 188 EPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDREEHSSYTLTVEARDGNGE 247
Query: 238 --DGLTATASAIITLDDINDNAPEFTRDEFFMEAIEAVSGVDVGRLEVEDRDLPGSPNWV 295
D A I + D+NDN P E V+V R++V D D GS NW+
Sbjct: 248 VTDKPVKQAQVQIRILDVNDNIPVVENKVLEGMVEENQVNVEVTRIKVFDADEIGSDNWL 307
Query: 296 ARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESCEHYELKVSVQNEAPL-QAAALR 354
A FT G+ G F I TD +TNEG+++++K +DYE ++ + V V N+A ++ +
Sbjct: 308 ANFTFASGNEGGYFHIETDAQTNEGIVTLIKEVDYEEMKNLDFSVIVANKAAFHKSIRSK 367
Query: 355 AERGQAKVRVHVQDTNEPPVFQENPLRTSLAEG---APPGTLVATFSARDPDTEQLQRLS 411
+ ++V V++ E F+ + + ++E + G ++ F A D DT
Sbjct: 368 YKPTPIPIKVKVKNVKEGIHFKSSVISIYVSESMDRSSKGQIIGNFQAFDEDTGLPAHAR 427
Query: 412 YSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYRAIVLAQDDASQPRTATGTLSI 471
Y K D ++W+ VD+ T I+ + S +++ G Y ++A + +T TGT+ I
Sbjct: 428 YVKLEDRDNWISVDSVTSEIKLAKLPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLI 487
Query: 472 EILEVNDHAPVLAPPPPGSLCSEPHQGPGLLLGATDEDLPPHGAPFHFQLSPRLPELGRN 531
+ ++ND+ P L P ++C H + + A D D P+ PF F + + P +
Sbjct: 488 NVEDINDNCPTLIEPVQ-TIC---HDAEYVNVTAEDLDGHPNSGPFSFSVIDKPPGMAEK 543
Query: 532 WSLSQVNVSHARLRPRHQVPEGLHRLSLLLRDSGQPPQQREQPLNVTVCRCGKDGVCLPG 591
W +++ S + L + + G + L+ D+ +Q L +TVC C C
Sbjct: 544 WKIAR-QESTSVLLQQSEKKLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGC--- 599
Query: 592 AAALLAGGTGLSLGALVIVLASALLLLVLVLLVALRARFWKQSRGKGLLHGPQDDLRDNV 651
A GL A+ +++ A LLL+LV L+ L K ++G + G + L
Sbjct: 600 REAQHDSYVGLGPAAIALMIL-AFLLLLLVPLLLLMCHCGKGAKGFTPIPGTIEMLHP-- 656
Query: 652 LNYDEQGGGEEDQ 664
++ +G ED+
Sbjct: 657 --WNNEGAPPEDK 667
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.137 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,651,283
Number of Sequences: 37866
Number of extensions: 1950809
Number of successful extensions: 10497
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 185
Number of HSP's successfully gapped in prelim test: 55
Number of HSP's that attempted gapping in prelim test: 6170
Number of HSP's gapped (non-prelim): 1034
length of query: 814
length of database: 18,247,518
effective HSP length: 111
effective length of query: 703
effective length of database: 14,044,392
effective search space: 9873207576
effective search space used: 9873207576
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.