Search of human proteins with 4759230

Search of human proteins with 4759230

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4759230 transglutaminase 5 isoform 2 [Homo sapiens]
         (638 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4759230 transglutaminase 5 isoform 2 [Homo sapiens]               1305   0.0  
gi|94981556 transglutaminase 5 isoform 1 [Homo sapiens]              1181   0.0  
gi|16445035 transglutaminase 7 [Homo sapiens]                         541   e-154
gi|189458821 transglutaminase 3 precursor [Homo sapiens]              524   e-148
gi|148664232 transglutaminase 6 [Homo sapiens]                        522   e-148
gi|39777597 transglutaminase 2 isoform a [Homo sapiens]               447   e-125
gi|39777599 transglutaminase 2 isoform b [Homo sapiens]               386   e-107
gi|4507475 transglutaminase 1 [Homo sapiens]                          386   e-107
gi|119395709 coagulation factor XIII A1 subunit precursor [Homo ...   359   5e-99
gi|156627577 transglutaminase 4 (prostate) [Homo sapiens]             333   2e-91
gi|166362737 erythrocyte membrane protein band 4.2 isoform 2 [Ho...   297   2e-80
gi|166362735 erythrocyte membrane protein band 4.2 isoform 1 [Ho...   297   2e-80
gi|41327708 crumbs homolog 1 precursor [Homo sapiens]                  35   0.16 
gi|154090979 hypothetical protein LOC57481 [Homo sapiens]              33   1.1  
gi|4507773 ubiquitin-conjugating enzyme E2D 1 [Homo sapiens]           32   2.3  
gi|5453952 beta isoform of regulatory subunit B56, protein phosp...    31   3.1  
gi|31541941 heat shock 70kDa protein 4-like [Homo sapiens]             31   4.0  
gi|151101459 SAPS domain family, member 1 [Homo sapiens]               31   4.0  
gi|38327039 heat shock 70kDa protein 4 [Homo sapiens]                  30   8.9  
gi|118918407 spectrin repeat containing, nuclear envelope 2 isof...    30   8.9  
gi|118918403 spectrin repeat containing, nuclear envelope 2 isof...    30   8.9  

>gi|4759230 transglutaminase 5 isoform 2 [Homo sapiens]
          Length = 638

 Score = 1305 bits (3376), Expect = 0.0
 Identities = 638/638 (100%), Positives = 638/638 (100%)

Query: 1   MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFV 60
           MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFV
Sbjct: 1   MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFV 60

Query: 61  VETEDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLLDKSL 120
           VETEDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLLDKSL
Sbjct: 61  VETEDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLLDKSL 120

Query: 121 HFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANPAEWTGSVAIL 180
           HFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANPAEWTGSVAIL
Sbjct: 121 HFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANPAEWTGSVAIL 180

Query: 181 KQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTG 240
           KQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTG
Sbjct: 181 KQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTG 240

Query: 241 RILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRAIK 300
           RILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRAIK
Sbjct: 241 RILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRAIK 300

Query: 301 EGEVDLNYDTPFVFSMVNADCMSWLVQGGKEQKLHQDTSSVGNFISTKSIQSDERDDITE 360
           EGEVDLNYDTPFVFSMVNADCMSWLVQGGKEQKLHQDTSSVGNFISTKSIQSDERDDITE
Sbjct: 301 EGEVDLNYDTPFVFSMVNADCMSWLVQGGKEQKLHQDTSSVGNFISTKSIQSDERDDITE 360

Query: 361 NYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQDSPRSLHTPSLRPS 420
           NYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQDSPRSLHTPSLRPS
Sbjct: 361 NYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQDSPRSLHTPSLRPS 420

Query: 421 DVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHDGSPLSPFWQDT 480
           DVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHDGSPLSPFWQDT
Sbjct: 421 DVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHDGSPLSPFWQDT 480

Query: 481 AFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYPSI 540
           AFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYPSI
Sbjct: 481 AFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYPSI 540

Query: 541 TINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQQKVFLGVLKPQHQASI 600
           TINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQQKVFLGVLKPQHQASI
Sbjct: 541 TINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQQKVFLGVLKPQHQASI 600

Query: 601 ILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYVDFAL 638
           ILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYVDFAL
Sbjct: 601 ILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYVDFAL 638


>gi|94981556 transglutaminase 5 isoform 1 [Homo sapiens]
          Length = 720

 Score = 1181 bits (3056), Expect = 0.0
 Identities = 575/575 (100%), Positives = 575/575 (100%)

Query: 64  EDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLLDKSLHFQ 123
           EDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLLDKSLHFQ
Sbjct: 146 EDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLLDKSLHFQ 205

Query: 124 TDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANPAEWTGSVAILKQW 183
           TDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANPAEWTGSVAILKQW
Sbjct: 206 TDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANPAEWTGSVAILKQW 265

Query: 184 NATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRIL 243
           NATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRIL
Sbjct: 266 NATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRIL 325

Query: 244 GNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRAIKEGE 303
           GNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRAIKEGE
Sbjct: 326 GNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRAIKEGE 385

Query: 304 VDLNYDTPFVFSMVNADCMSWLVQGGKEQKLHQDTSSVGNFISTKSIQSDERDDITENYK 363
           VDLNYDTPFVFSMVNADCMSWLVQGGKEQKLHQDTSSVGNFISTKSIQSDERDDITENYK
Sbjct: 386 VDLNYDTPFVFSMVNADCMSWLVQGGKEQKLHQDTSSVGNFISTKSIQSDERDDITENYK 445

Query: 364 YEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQDSPRSLHTPSLRPSDVV 423
           YEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQDSPRSLHTPSLRPSDVV
Sbjct: 446 YEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQDSPRSLHTPSLRPSDVV 505

Query: 424 QVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHDGSPLSPFWQDTAFI 483
           QVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHDGSPLSPFWQDTAFI
Sbjct: 506 QVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHDGSPLSPFWQDTAFI 565

Query: 484 TLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYPSITIN 543
           TLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYPSITIN
Sbjct: 566 TLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYPSITIN 625

Query: 544 VLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQQKVFLGVLKPQHQASIILE 603
           VLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQQKVFLGVLKPQHQASIILE
Sbjct: 626 VLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQQKVFLGVLKPQHQASIILE 685

Query: 604 TVPFKSGQRQIQANMRSNKFKDIKGYRNVYVDFAL 638
           TVPFKSGQRQIQANMRSNKFKDIKGYRNVYVDFAL
Sbjct: 686 TVPFKSGQRQIQANMRSNKFKDIKGYRNVYVDFAL 720



 Score =  127 bits (320), Expect = 2e-29
 Identities = 63/63 (100%), Positives = 63/63 (100%)

Query: 1  MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFV 60
          MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFV
Sbjct: 1  MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFV 60

Query: 61 VET 63
          VET
Sbjct: 61 VET 63


>gi|16445035 transglutaminase 7 [Homo sapiens]
          Length = 710

 Score =  541 bits (1393), Expect = e-154
 Identities = 281/580 (48%), Positives = 366/580 (63%), Gaps = 25/580 (4%)

Query: 64  EDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLLDKSLHFQ 123
           ED VYL SE   QEY+M DYGF+Y+G + +I   PWNYGQFE+ IIDIC ++L+KSL+  
Sbjct: 147 EDDVYLPSEILLQEYIMRDYGFVYKGHERFITSWPWNYGQFEEDIIDICFEILNKSLYHL 206

Query: 124 TDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANPAEWTGSVAILKQW 183
            +PA DC+ R   VYV RVV AMINSNDDNGVL GNW E+Y+ G +P EW GSVAIL+QW
Sbjct: 207 KNPAKDCSQRNDVVYVCRVVSAMINSNDDNGVLQGNWGEDYSKGVSPLEWKGSVAILQQW 266

Query: 184 NATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRIL 243
           +A G QPV+YGQCWVFA+VMCTVMRCLG+PTRV++NF S H+ D NL ID YYD    +L
Sbjct: 267 SARGGQPVKYGQCWVFASVMCTVMRCLGVPTRVVSNFRSAHNVDRNLTIDTYYDRNAEML 326

Query: 244 GNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRAIKEGE 303
             +K+D IWNFHVWNECWM RKDLPP Y GWQVLD TPQ+ S+G++CCGPASV+AI+EG+
Sbjct: 327 STQKRDKIWNFHVWNECWMIRKDLPPGYNGWQVLDPTPQQTSSGLFCCGPASVKAIREGD 386

Query: 304 VDLNYDTPFVFSMVNADCMSWLVQGGKEQK-LHQDTSSVGNFISTKSIQSDERDDITENY 362
           V L YDTPFV++ VNAD + WL+  G+ Q+ L  +TSS+G  ISTK + SD+R  IT +Y
Sbjct: 387 VHLAYDTPFVYAEVNADEVIWLLGDGQAQEILAHNTSSIGKEISTKMVGSDQRQSITSSY 446

Query: 363 KYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQDSPRSLHTPSLRPSDV 422
           KY EGS +ER VF+KA +K+             L P R +    D    L +  LR    
Sbjct: 447 KYPEGSPEERAVFMKASRKM-------------LGPQRASLPFLD---LLESGGLRDQ-- 488

Query: 423 VQVSLKFKLLDPPNMGQDICFVLLALNMSSQFK-----DLKVNLSAQSLLHDGSPLSPFW 477
               L+  L   P  GQD+  +L    +           L V   AQ+LLH G    PFW
Sbjct: 489 -PAQLQLHLARIPEWGQDLQLLLRIQRVPDSTHPRGPIGLVVRFCAQALLHGGGTQKPFW 547

Query: 478 QDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSY 537
           + T  + L   +   +P  + YS Y   L+ +KLIR+S + E + +   +LV K I L  
Sbjct: 548 RHTVRMNLDFGKETQWPLLLPYSNYRNKLTDEKLIRVSGIAEVEETGRSMLVLKDICLEP 607

Query: 538 PSITINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQQKVFLGVLKPQHQ 597
           P ++I V   A V + L + V  +N L   +  C + +EGSGL   Q    LG L   H 
Sbjct: 608 PHLSIEVSERAEVGKALRVHVTLTNTLMVALSSCTMVLEGSGLINGQIAKDLGTLVAGHT 667

Query: 598 ASIILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYVDFA 637
             I L+  P K+G RQ+Q  + SN+ K+IKGY++++V  A
Sbjct: 668 LQIQLDLYPTKAGPRQLQVLISSNEVKEIKGYKDIFVTVA 707



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 33/59 (55%), Positives = 38/59 (64%), Gaps = 1/59 (1%)

Query: 5  LEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFVVET 63
          L +   DLQSSRNN  HHT+E+ V  L VRRGQ F L L F +R FQ   D+I FV ET
Sbjct: 7  LRLESVDLQSSRNNKEHHTQEMGVKRLTVRRGQPFYLRLSF-SRPFQSQNDHITFVAET 64


>gi|189458821 transglutaminase 3 precursor [Homo sapiens]
          Length = 693

 Score =  524 bits (1349), Expect = e-148
 Identities = 268/572 (46%), Positives = 370/572 (64%), Gaps = 24/572 (4%)

Query: 65  DAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLLDKSLHFQT 124
           D+V++ +  +R+EYV  D G I+ GS N I    WN+GQFE+ I+ ICL +LD+SL+F+ 
Sbjct: 142 DSVFMGNHAEREEYVQEDAGIIFVGSTNRIGMIGWNFGQFEEDILSICLSILDRSLNFRR 201

Query: 125 DPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANPAEWTGSVAILKQWN 184
           D ATD A R  P YV RV+ AMINSNDDNGVL GNWS  YT G +P  W GSV ILK W 
Sbjct: 202 DAATDVASRNDPKYVGRVLSAMINSNDDNGVLAGNWSGTYTGGRDPRSWNGSVEILKNWK 261

Query: 185 ATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRILG 244
            +G  PVRYGQCWVFA  + T +R LGIP+RVITNF+S HDTD NL +D YYD  G  L 
Sbjct: 262 KSGFSPVRYGQCWVFAGTLNTALRSLGIPSRVITNFNSAHDTDRNLSVDVYYDPMGNPL- 320

Query: 245 NKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRAIKEGEV 304
           +K  D++WNFHVWNE W  R DL P+YGGWQVLDATPQE S GV+ CGPASV  ++EG+V
Sbjct: 321 DKGSDSVWNFHVWNEGWFVRSDLGPSYGGWQVLDATPQERSQGVFQCGPASVIGVREGDV 380

Query: 305 DLNYDTPFVFSMVNADCMSWLVQG--GKEQKLHQDTSSVGNFISTKSIQSDERDDITENY 362
            LN+D PF+F+ VNAD ++WL     GK+ K   ++ ++G +ISTK++ S+ R D+T+ Y
Sbjct: 381 QLNFDMPFIFAEVNADRITWLYDNTTGKQWKNSVNSHTIGRYISTKAVGSNARMDVTDKY 440

Query: 363 KYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQDSPRSLHTPSLRPSDV 422
           KY EGS QERQVF KAL KLK                  T  +  S   L T    PS  
Sbjct: 441 KYPEGSDQERQVFQKALGKLKPN----------------TPFAATSSMGLETEEQEPS-- 482

Query: 423 VQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHDGSPLSPFWQDTAF 482
             +  K K+     +G+++  VLL  N+S   K + VN++A +++++G+ +   W+D+A 
Sbjct: 483 --IIGKLKVAGMLAVGKEVNLVLLLKNLSRDTKTVTVNMTAWTIIYNGTLVHEVWKDSAT 540

Query: 483 ITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYPSITI 542
           ++L P+E   +P KISY+QY +YL +D +IRI+A+ +     E ++V + I L  P++T+
Sbjct: 541 MSLDPEEEAEHPIKISYAQYEKYLKSDNMIRITAVCKVPDESE-VVVERDIILDNPTLTL 599

Query: 543 NVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQQKVFLGVLKPQHQASIIL 602
            VL  A V +P+++Q++FSNPL E V DCVL VEGSGL     K+ +  L P+  + +  
Sbjct: 600 EVLNEARVRKPVNVQMLFSNPLDEPVRDCVLMVEGSGLLLGNLKIDVPTLGPKEGSRVRF 659

Query: 603 ETVPFKSGQRQIQANMRSNKFKDIKGYRNVYV 634
           + +P +SG +Q+ A+   NKF  IK   ++ V
Sbjct: 660 DILPSRSGTKQLLADFSCNKFPAIKAMLSIDV 691



 Score = 30.0 bits (66), Expect = 6.8
 Identities = 18/59 (30%), Positives = 31/59 (52%), Gaps = 2/59 (3%)

Query: 5  LEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFVVET 63
          L V   + Q++ N   HHT++ +   L++RRGQ F + L   N+      + + F+V T
Sbjct: 4  LGVQSINWQTAFNRQAHHTDKFSSQELILRRGQNFQV-LMIMNKGLGSN-ERLEFIVST 60


>gi|148664232 transglutaminase 6 [Homo sapiens]
          Length = 706

 Score =  522 bits (1344), Expect = e-148
 Identities = 270/572 (47%), Positives = 386/572 (67%), Gaps = 12/572 (2%)

Query: 64  EDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLLDKSLHFQ 123
           ED V+L SE +RQEYV++D G I++G +  IR   WNYGQFE+ I++ICL +LD+S   Q
Sbjct: 142 EDDVFLASEEERQEYVLSDSGIIFRGVEKHIRAQGWNYGQFEEDILNICLSILDRSPGHQ 201

Query: 124 TDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANPAEWTGSVAILKQW 183
            +PATD + R +P+YV+RV+ AM+NSN+D GV+ G W   Y  G +P  W GSVAIL++W
Sbjct: 202 NNPATDVSCRHNPIYVTRVISAMVNSNNDRGVVQGQWQGKYGGGTSPLHWRGSVAILQKW 261

Query: 184 NATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRIL 243
                +PV+YGQCWVFA V+CTV+RCLGI TRV++NF+S HDTD NL +D+Y D+ GR L
Sbjct: 262 LKGRYKPVKYGQCWVFAGVLCTVLRCLGIATRVVSNFNSAHDTDQNLSVDKYVDSFGRTL 321

Query: 244 GNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRAIKEGE 303
            +  +D++WNFHVWNE W AR+DL P+Y GWQVLDATPQE S GV+ CGPASV AI+EG+
Sbjct: 322 EDLTEDSMWNFHVWNESWFARQDLGPSYNGWQVLDATPQEESEGVFRCGPASVTAIREGD 381

Query: 304 VDLNYDTPFVFSMVNADCMSWL-VQGGKEQKLHQDTSSVGNFISTKSIQSDERDDITENY 362
           V L +D PFVF+ VNAD ++WL  +    ++++ +T  +G  ISTK++ SD R DIT+ Y
Sbjct: 382 VHLAHDGPFVFAEVNADYITWLWHEDESRERVYSNTKKIGRCISTKAVGSDSRVDITDLY 441

Query: 363 KYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQDSPRSLHTPSLRPSDV 422
           KY EGS +ERQV+ KA+ +L       S R   ++ +    L +D    L  P+ +PS  
Sbjct: 442 KYPEGSRKERQVYSKAVNRL--FGVEASGRRIWIRRAGGRCLWRD---DLLEPATKPS-- 494

Query: 423 VQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHDGSPLSPFWQDTAF 482
             ++ KFK+L+PP +G D+   L   N++S+ + ++VNLS  ++L+   P++    ++  
Sbjct: 495 --IAGKFKVLEPPMLGHDLRLALCLANLTSRAQRVRVNLSGATILYTRKPVAEILHESHA 552

Query: 483 ITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYPSITI 542
           + L P+E K  P  ISYS+Y + L+ DK I ++A+    +  EK+LV K ITL    ITI
Sbjct: 553 VRLGPQEEKRIPITISYSKYKEDLTEDKKILLAAMC-LVTKGEKLLVEKDITLE-DFITI 610

Query: 543 NVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQQKVFLGVLKPQHQASIIL 602
            VLG A+V   ++++V   NPL E+V+DC L VEGSGL ++Q  + +  L+PQ +AS+  
Sbjct: 611 KVLGPAMVGVAVTVEVTVVNPLIERVKDCALMVEGSGLLQEQLSIDVPTLEPQERASVQF 670

Query: 603 ETVPFKSGQRQIQANMRSNKFKDIKGYRNVYV 634
           +  P KSG RQ+Q ++ S  F DIKG+  V+V
Sbjct: 671 DITPSKSGPRQLQVDLVSPHFPDIKGFVIVHV 702



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 21/40 (52%), Positives = 26/40 (65%)

Query: 4  GLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTL 43
          G+ V   D Q SRN   HHT+E     L+VRRGQ+F+LTL
Sbjct: 3  GIRVTKVDWQRSRNGAAHHTQEYPCPELVVRRGQSFSLTL 42


>gi|39777597 transglutaminase 2 isoform a [Homo sapiens]
          Length = 687

 Score =  447 bits (1150), Expect = e-125
 Identities = 241/574 (41%), Positives = 326/574 (56%), Gaps = 39/574 (6%)

Query: 65  DAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLLDKSLHFQT 124
           DAVYLDSE +RQEYV+   GFIYQGS  +I+  PWN+GQFED I+DICL LLD +  F  
Sbjct: 146 DAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPWNFGQFEDGILDICLILLDVNPKFLK 205

Query: 125 DPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANPAEWTGSVAILKQWN 184
           +   DC+ R SPVYV RVV  M+N NDD GVL G W  NY DG +P  W GSV IL++W 
Sbjct: 206 NAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGRWDNNYGDGVSPMSWIGSVDILRRWK 265

Query: 185 ATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRILG 244
             GCQ V+YGQCWVFAAV CTV+RCLGIPTRV+TN++S HD + NL+I+ + +  G I G
Sbjct: 266 NHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEFGEIQG 325

Query: 245 NKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRAIKEGEV 304
           + K + IWNFH W E WM R DL P Y GWQ LD TPQE S G YCCGP  VRAIKEG++
Sbjct: 326 D-KSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPTPQEKSEGTYCCGPVPVRAIKEGDL 384

Query: 305 DLNYDTPFVFSMVNADCMSWLVQ-GGKEQKLHQDTSSVGNFISTKSIQSDERDDITENYK 363
              YD PFVF+ VNAD + W+ Q  G   K    +  VG  ISTKS+  DER+DIT  YK
Sbjct: 385 STKYDAPFVFAEVNADVVDWIQQDDGSVHKSINRSLIVGLKISTKSVGRDEREDITHTYK 444

Query: 364 YEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQDSPRSLHTPSLRPSDVV 423
           Y EGS +ER+ F                                  R+ H   L   +  
Sbjct: 445 YPEGSSEEREAF---------------------------------TRANHLNKLAEKEET 471

Query: 424 QVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHDGSPLSPFWQDTAFI 483
            ++++ ++    NMG D        N +++    ++ L A+++ ++G  L P       +
Sbjct: 472 GMAMRIRVGQSMNMGSDFDVFAHITNNTAEEYVCRLLLCARTVSYNGI-LGPECGTKYLL 530

Query: 484 TLS--PKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYPSIT 541
            L+  P   K+ P  I Y +Y   L+   LI++ AL  E      +L  + + L  P I 
Sbjct: 531 NLNLEPFSEKSVPLCILYEKYRDCLTESNLIKVRALLVEPVINSYLLAERDLYLENPEIK 590

Query: 542 INVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQQKVFL-GVLKPQHQASI 600
           I +LG     + L  +V   NPL   +E C  TVEG+GL ++Q+ V +   ++   +  +
Sbjct: 591 IRILGEPKQKRKLVAEVSLQNPLPVALEGCTFTVEGAGLTEEQKTVEIPDPVEAGEEVKV 650

Query: 601 ILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYV 634
            ++ +P   G  ++  N  S+K K +KG+RNV +
Sbjct: 651 RMDLLPLHMGLHKLVVNFESDKLKAVKGFRNVII 684



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 26/66 (39%), Positives = 40/66 (60%)

Query: 1  MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFV 60
          MA+ L +   DL+   N   HHT ++  + L+VRRGQ F LTL+F  R+++  +D++ F 
Sbjct: 1  MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFS 60

Query: 61 VETEDA 66
          V T  A
Sbjct: 61 VVTGPA 66


>gi|39777599 transglutaminase 2 isoform b [Homo sapiens]
          Length = 548

 Score =  386 bits (992), Expect = e-107
 Identities = 187/328 (57%), Positives = 224/328 (68%), Gaps = 4/328 (1%)

Query: 65  DAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLLDKSLHFQT 124
           DAVYLDSE +RQEYV+   GFIYQGS  +I+  PWN+GQFED I+DICL LLD +  F  
Sbjct: 146 DAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPWNFGQFEDGILDICLILLDVNPKFLK 205

Query: 125 DPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANPAEWTGSVAILKQWN 184
           +   DC+ R SPVYV RVV  M+N NDD GVL G W  NY DG +P  W GSV IL++W 
Sbjct: 206 NAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGRWDNNYGDGVSPMSWIGSVDILRRWK 265

Query: 185 ATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRILG 244
             GCQ V+YGQCWVFAAV CTV+RCLGIPTRV+TN++S HD + NL+I+ + +  G I G
Sbjct: 266 NHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEFGEIQG 325

Query: 245 NKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRAIKEGEV 304
           + K + IWNFH W E WM R DL P Y GWQ LD TPQE S G YCCGP  VRAIKEG++
Sbjct: 326 D-KSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPTPQEKSEGTYCCGPVPVRAIKEGDL 384

Query: 305 DLNYDTPFVFSMVNADCMSWLVQ-GGKEQKLHQDTSSVGNFISTKSIQSDERDDITENYK 363
              YD PFVF+ VNAD + W+ Q  G   K    +  VG  ISTKS+  DER+DIT  YK
Sbjct: 385 STKYDAPFVFAEVNADVVDWIQQDDGSVHKSINRSLIVGLKISTKSVGRDEREDITHTYK 444

Query: 364 YEEGSLQERQVFLKA--LQKLKARSFHG 389
           Y EGS +ER+ F +A  L KL  +   G
Sbjct: 445 YPEGSSEEREAFTRANHLNKLAEKEETG 472



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 26/66 (39%), Positives = 40/66 (60%)

Query: 1  MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFV 60
          MA+ L +   DL+   N   HHT ++  + L+VRRGQ F LTL+F  R+++  +D++ F 
Sbjct: 1  MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFS 60

Query: 61 VETEDA 66
          V T  A
Sbjct: 61 VVTGPA 66


>gi|4507475 transglutaminase 1 [Homo sapiens]
          Length = 817

 Score =  386 bits (991), Expect = e-107
 Identities = 218/572 (38%), Positives = 319/572 (55%), Gaps = 39/572 (6%)

Query: 64  EDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLLDKSLHFQ 123
           ED VY+D E  RQEYV+N+ G IY G++  I    WNYGQF+  ++D CL +LD+     
Sbjct: 253 EDIVYVDHEDWRQEYVLNESGRIYYGTEAQIGERTWNYGQFDHGVLDACLYILDRR---- 308

Query: 124 TDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANPAEWTGSVAILKQW 183
                    RG PV VSRV+ AM+NS DDNGVL GNWS +Y+ G NP+ W GSV IL  +
Sbjct: 309 ---GMPYGGRGDPVNVSRVISAMVNSLDDNGVLIGNWSGDYSRGTNPSAWVGSVEILLSY 365

Query: 184 NATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRIL 243
             TG   V YGQCWVFA V  TV+RCLG+ TR +TNF+S HDTD +L +D Y+D   + L
Sbjct: 366 LRTGYS-VPYGQCWVFAGVTTTVLRCLGLATRTVTNFNSAHDTDTSLTMDIYFDENMKPL 424

Query: 244 GNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRAIKEGE 303
            +   D++WNFHVWN+CWM R DLP  + GWQV+DATPQE S+G++CCGP SV +IK G 
Sbjct: 425 EHLNHDSVWNFHVWNDCWMKRPDLPSGFDGWQVVDATPQETSSGIFCCGPCSVESIKNGL 484

Query: 304 VDLNYDTPFVFSMVNADCMSWLVQG-GKEQKLHQDTSSVGNFISTKSIQSDERDDITENY 362
           V + YDTPF+F+ VN+D + W  Q  G  + ++ +  ++G  I TK+I S+ R+DIT  Y
Sbjct: 485 VYMKYDTPFIFAEVNSDKVYWQRQDDGSFKIVYVEEKAIGTLIVTKAISSNMREDITYLY 544

Query: 363 KYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQDSPRSLHTPSLRPSDV 422
           K+ EGS  ER    KA++   A   HGS         +P   +           +   D 
Sbjct: 545 KHPEGSDAER----KAVETAAA---HGS---------KPNVYANRGSAEDVAMQVEAQDA 588

Query: 423 VQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHDGSPLSPFWQDTAF 482
           V             MGQD+   ++ +N SS  + +K++L      + G   + F +    
Sbjct: 589 V-------------MGQDLMVSVMLINHSSSRRTVKLHLYLSVTFYTGVSGTIFKETKKE 635

Query: 483 ITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYPSITI 542
           + L+P  +      ++Y +Y  +L     + ++  G  K S + +       L  P +++
Sbjct: 636 VELAPGASDRVTMPVAYKEYRPHLVDQGAMLLNVSGHVKESGQVLAKQHTFRLRTPDLSL 695

Query: 543 NVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQQKVFLGVLKPQHQASIIL 602
            +LGAAVV Q   +Q++F NPL   + + V  +EGSGL ++ + + +G +      ++  
Sbjct: 696 TLLGAAVVGQECEVQIVFKNPLPVTLTNVVFRLEGSGL-QRPKILNVGDIGGNETVTLRQ 754

Query: 603 ETVPFKSGQRQIQANMRSNKFKDIKGYRNVYV 634
             VP + G RQ+ A++ S +   + G   V V
Sbjct: 755 SFVPVRPGPRQLIASLDSPQLSQVHGVIQVDV 786



 Score = 37.4 bits (85), Expect = 0.043
 Identities = 17/37 (45%), Positives = 23/37 (62%)

Query: 7   VALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTL 43
           V L   +S +N   HHT+E   D L+VRRGQ F++ L
Sbjct: 115 VDLLSSRSDQNRREHHTDEYEYDELIVRRGQPFHMLL 151


>gi|119395709 coagulation factor XIII A1 subunit precursor [Homo
           sapiens]
          Length = 732

 Score =  359 bits (921), Expect = 5e-99
 Identities = 204/572 (35%), Positives = 305/572 (53%), Gaps = 37/572 (6%)

Query: 64  EDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLLDKSLHFQ 123
           +DAVYLD+E +R+EYV+ND G I+ G  N I+   W+YGQFED I+D CL ++D++    
Sbjct: 191 DDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRSWSYGQFEDGILDTCLYVMDRA---- 246

Query: 124 TDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANPAEWTGSVAILKQW 183
                D + RG+P+ VSRV  AM+N+ DD GVL G+W   Y  G  P+ WTGSV IL ++
Sbjct: 247 ---QMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNIYAYGVPPSAWTGSVDILLEY 303

Query: 184 NATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRIL 243
            ++   PVRYGQCWVFA V  T +RCLGIP R++TN+ S HD D NL +D + +  G + 
Sbjct: 304 RSSE-NPVRYGQCWVFAGVFNTFLRCLGIPARIVTNYFSAHDNDANLQMDIFLEEDGNVN 362

Query: 244 GNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRAIKEGE 303
               KD++WN+H WNE WM R DLP  +GGWQ +D+TPQE S+G+Y CGPASV+AIK G 
Sbjct: 363 SKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAIKHGH 422

Query: 304 VDLNYDTPFVFSMVNADCMSWLVQ-GGKEQKLHQDTSSVGNFISTKSIQSDERDDITENY 362
           V   +D PFVF+ VN+D +    +  G     + D + +G  I TK I  D   DIT+ Y
Sbjct: 423 VCFQFDAPFVFAEVNSDLIYITAKKDGTHVVENVDATHIGKLIVTKQIGGDGMMDITDTY 482

Query: 363 KYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQDSPRSLHTPSLRPSDV 422
           K++EG  +ER                             T+L   + + L+T  +  S  
Sbjct: 483 KFQEGQEEERLAL-------------------------ETALMYGAKKPLNTEGVMKSRS 517

Query: 423 VQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHDGSPLSPFWQDTAF 482
             V + F++ +   +G+D    +   N S     +   LSA    + G P + F ++T  
Sbjct: 518 -NVDMDFEV-ENAVLGKDFKLSITFRNNSHNRYTITAYLSANITFYTGVPKAEFKKETFD 575

Query: 483 ITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYPSITI 542
           +TL P   K     I   +Y   L     +          + + +   K   L+ P I I
Sbjct: 576 VTLEPLSFKKEAVLIQAGEYMGQLLEQASLHFFVTARINETRDVLAKQKSTVLTIPEIII 635

Query: 543 NVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQQKVFLGVLKPQHQASIIL 602
            V G  VV   +++ V F+NPL E + +  + ++G G+ +  +K+F  + +P        
Sbjct: 636 KVRGTQVVGSDMTVTVEFTNPLKETLRNVWVHLDGPGVTRPMKKMFREI-RPNSTVQWEE 694

Query: 603 ETVPFKSGQRQIQANMRSNKFKDIKGYRNVYV 634
              P+ SG R++ A+M S+  + + G  +V +
Sbjct: 695 VCRPWVSGHRKLIASMSSDSLRHVYGELDVQI 726



 Score = 33.1 bits (74), Expect = 0.80
 Identities = 19/46 (41%), Positives = 29/46 (63%), Gaps = 3/46 (6%)

Query: 17  NNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFVVE 62
           N V HHT++   + L+VRRGQ+F + + F +R + P  D  +F VE
Sbjct: 61  NKVDHHTDKYENNKLIVRRGQSFYVQIDF-SRPYDPRRD--LFRVE 103


>gi|156627577 transglutaminase 4 (prostate) [Homo sapiens]
          Length = 684

 Score =  333 bits (855), Expect = 2e-91
 Identities = 200/590 (33%), Positives = 304/590 (51%), Gaps = 48/590 (8%)

Query: 55  DNIIFVVET----EDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIID 110
           +NI++++      ED V++  E +R+EY++ND G  Y G+   I+  PWN+GQFE  ++D
Sbjct: 131 ENILYLLFNPWCKEDMVFMPDEDERKEYILNDTGCHYVGAARSIKCKPWNFGQFEKNVLD 190

Query: 111 ICLKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANP 170
            C+ LL +S    TD       R  PV V R +CAM++     GVL GNW+ +Y  G  P
Sbjct: 191 CCISLLTESSLKPTD-------RRDPVLVCRAMCAMMSFEKGQGVLIGNWTGDYEGGTAP 243

Query: 171 AEWTGSVAILKQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNL 230
            +WTGS  IL+Q+  T  Q V +GQCWVFA ++ TV+R LGIP R +T FDS HDT+ NL
Sbjct: 244 YKWTGSAPILQQYYNTK-QAVCFGQCWVFAGILTTVLRALGIPARSVTGFDSAHDTERNL 302

Query: 231 IIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYC 290
            +D Y +  G  + +   D++WNFHVW + WM R DLP  Y GWQ +DATPQE S GV+C
Sbjct: 303 TVDTYVNENGEKITSMTHDSVWNFHVWTDAWMKRPDLPKGYDGWQAVDATPQERSQGVFC 362

Query: 291 CGPASVRAIKEGEVDLNYDTPFVFSMVNADCMSWLVQ--GGKEQ--KLHQDTSSVGNFIS 346
           CGP+ + AI++G++ + YDT FVFS VN D + WLV+   G+E+   +  +T+S+G  IS
Sbjct: 363 CGPSPLTAIRKGDIFIVYDTRFVFSEVNGDRLIWLVKMVNGQEELHVISMETTSIGKNIS 422

Query: 347 TKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQ 406
           TK++  D R DIT  YKY EGS +ERQV   A   L +   H           RP     
Sbjct: 423 TKAVGQDRRRDITYEYKYPEGSSEERQVMDHAFLLLSSEREH----------RRPV---- 468

Query: 407 DSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSL 466
                LH  S++  DV+             +G  + F ++    ++  +++ +  S +  
Sbjct: 469 -KENFLHM-SVQSDDVL-------------LGNSVNFTVILKRKTAALQNVNILGSFELQ 513

Query: 467 LHDGSPLSPF--WQDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSP 524
           L+ G  ++       T+ I     E        +Y      L  + +IR   + E   S 
Sbjct: 514 LYTGKKMAKLCDLNKTSQIQGQVSEVTLTLDSKTYINSLAILDDEPVIRGFIIAEIVESK 573

Query: 525 EKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQ 584
           E +      +  YP  +I +     + Q L    IF N L+  + D   ++E  G+   Q
Sbjct: 574 EIMASEVFTSFQYPEFSIELPNTGRIGQLLVCNCIFKNTLAIPLTDVKFSLESLGISSLQ 633

Query: 585 QKVFLGVLKPQHQASIILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYV 634
                G ++P       ++  P K+G ++    + S + K+I   + V +
Sbjct: 634 TSDH-GTVQPGETIQSQIKCTPIKTGPKKFIVKLSSKQVKEINAQKIVLI 682



 Score = 30.8 bits (68), Expect = 4.0
 Identities = 16/39 (41%), Positives = 20/39 (51%)

Query: 5  LEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTL 43
          L+V   D  +  N V HHT E      + RRGQ F+L L
Sbjct: 8  LQVLHIDFLNQDNAVSHHTWEFQTSSPVFRRGQVFHLRL 46


>gi|166362737 erythrocyte membrane protein band 4.2 isoform 2 [Homo
           sapiens]
          Length = 691

 Score =  297 bits (760), Expect = 2e-80
 Identities = 182/572 (31%), Positives = 285/572 (49%), Gaps = 32/572 (5%)

Query: 64  EDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLLDKSLHFQ 123
           EDAV+L +E QR EY++N  G IY G+ + I+   W++GQFE  +ID+ L+LL K    +
Sbjct: 144 EDAVFLKNEAQRMEYLLNQNGLIYLGTADCIQAESWDFGQFEGDVIDLSLRLLSKDKQVE 203

Query: 124 TDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANPAEWTGSVAILKQW 183
                       PV+V+RV+ A+++   +  VL    ++   +GA   +  GSV IL+QW
Sbjct: 204 K--------WSQPVHVARVLGALLHFLKEQRVLPTPQTQATQEGALLNKRRGSVPILRQW 255

Query: 184 NATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRIL 243
                +PV  GQ WV AAV CTV+RCLGIP RV+T F S   T G L+IDEYY+  G   
Sbjct: 256 LTGRGRPVYDGQAWVLAAVACTVLRCLGIPARVVTTFASAQGTGGRLLIDEYYNEEGLQN 315

Query: 244 GNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRAIKEGE 303
           G  ++  IW F    ECWM R  LP  Y GWQ+L  +       +  C    VRA+KEG 
Sbjct: 316 GEGQRGRIWIFQTSTECWMTRPALPQGYDGWQILHPSAPNGGGVLGSCDLVPVRAVKEGT 375

Query: 304 VDLNYDTPFVFSMVNADCMSW-LVQGGKEQKLHQDTSSVGNFISTKSIQSDERDDITENY 362
           + L      +F+ +NA C+ W   + G  +    +T  VGN ISTK + SD  +DIT+NY
Sbjct: 376 LGLTPAVSDLFAAINASCVVWKCCEDGTLELTDSNTKYVGNNISTKGVGSDRCEDITQNY 435

Query: 363 KYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQDSPRSLHTPSLRPSDV 422
           KY EGSLQE++V  +  ++   R      R   L+ + P  L   +P SL    LR    
Sbjct: 436 KYPEGSLQEKEVLERVEKEKMEREKDNGIRPPSLETASPLYLLLKAPSSL---PLRGDAQ 492

Query: 423 VQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHDGSPLSPFWQDTAF 482
           + V+L                    +N S Q K +++ +  Q++ ++G   +  W+    
Sbjct: 493 ISVTL--------------------VNHSEQEKAVQLAIGVQAVHYNGVLAAKLWRKKLH 532

Query: 483 ITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYPSITI 542
           +TLS    K     + +S + +    +  +R++A+     S       + I +  P + I
Sbjct: 533 LTLSANLEKIITIGLFFSNFERNPPENTFLRLTAMATHSESNLSCFAQEDIAICRPHLAI 592

Query: 543 NVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQQKVFLGVLKPQHQASIIL 602
            +   A   QPL+  V   N L   +EDCV+++ G GL  +++      + P++      
Sbjct: 593 KMPEKAEQYQPLTASVSLQNSLDAPMEDCVISILGRGLIHRERSYRFRSVWPENTMCAKF 652

Query: 603 ETVPFKSGQRQIQANMRSNKFKDIKGYRNVYV 634
           +  P   G +++   +  N F+++  Y++V V
Sbjct: 653 QFTPTHVGLQRLTVEVDCNMFQNLTNYKSVTV 684



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 27/65 (41%), Positives = 37/65 (56%), Gaps = 2/65 (3%)

Query: 1  MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRN--RSFQPGLDNII 58
          M Q L +   D Q++RNN  HHT+ ++   L VRRGQ F + LYFR   R+F P L  + 
Sbjct: 1  MGQALGIKSCDFQAARNNEEHHTKALSSRRLFVRRGQPFTIILYFRAPVRAFLPALKKVA 60

Query: 59 FVVET 63
             +T
Sbjct: 61 LTAQT 65


>gi|166362735 erythrocyte membrane protein band 4.2 isoform 1 [Homo
           sapiens]
          Length = 721

 Score =  297 bits (760), Expect = 2e-80
 Identities = 182/572 (31%), Positives = 285/572 (49%), Gaps = 32/572 (5%)

Query: 64  EDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLLDKSLHFQ 123
           EDAV+L +E QR EY++N  G IY G+ + I+   W++GQFE  +ID+ L+LL K    +
Sbjct: 174 EDAVFLKNEAQRMEYLLNQNGLIYLGTADCIQAESWDFGQFEGDVIDLSLRLLSKDKQVE 233

Query: 124 TDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANPAEWTGSVAILKQW 183
                       PV+V+RV+ A+++   +  VL    ++   +GA   +  GSV IL+QW
Sbjct: 234 K--------WSQPVHVARVLGALLHFLKEQRVLPTPQTQATQEGALLNKRRGSVPILRQW 285

Query: 184 NATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRIL 243
                +PV  GQ WV AAV CTV+RCLGIP RV+T F S   T G L+IDEYY+  G   
Sbjct: 286 LTGRGRPVYDGQAWVLAAVACTVLRCLGIPARVVTTFASAQGTGGRLLIDEYYNEEGLQN 345

Query: 244 GNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRAIKEGE 303
           G  ++  IW F    ECWM R  LP  Y GWQ+L  +       +  C    VRA+KEG 
Sbjct: 346 GEGQRGRIWIFQTSTECWMTRPALPQGYDGWQILHPSAPNGGGVLGSCDLVPVRAVKEGT 405

Query: 304 VDLNYDTPFVFSMVNADCMSW-LVQGGKEQKLHQDTSSVGNFISTKSIQSDERDDITENY 362
           + L      +F+ +NA C+ W   + G  +    +T  VGN ISTK + SD  +DIT+NY
Sbjct: 406 LGLTPAVSDLFAAINASCVVWKCCEDGTLELTDSNTKYVGNNISTKGVGSDRCEDITQNY 465

Query: 363 KYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQDSPRSLHTPSLRPSDV 422
           KY EGSLQE++V  +  ++   R      R   L+ + P  L   +P SL    LR    
Sbjct: 466 KYPEGSLQEKEVLERVEKEKMEREKDNGIRPPSLETASPLYLLLKAPSSL---PLRGDAQ 522

Query: 423 VQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHDGSPLSPFWQDTAF 482
           + V+L                    +N S Q K +++ +  Q++ ++G   +  W+    
Sbjct: 523 ISVTL--------------------VNHSEQEKAVQLAIGVQAVHYNGVLAAKLWRKKLH 562

Query: 483 ITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYPSITI 542
           +TLS    K     + +S + +    +  +R++A+     S       + I +  P + I
Sbjct: 563 LTLSANLEKIITIGLFFSNFERNPPENTFLRLTAMATHSESNLSCFAQEDIAICRPHLAI 622

Query: 543 NVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQQKVFLGVLKPQHQASIIL 602
            +   A   QPL+  V   N L   +EDCV+++ G GL  +++      + P++      
Sbjct: 623 KMPEKAEQYQPLTASVSLQNSLDAPMEDCVISILGRGLIHRERSYRFRSVWPENTMCAKF 682

Query: 603 ETVPFKSGQRQIQANMRSNKFKDIKGYRNVYV 634
           +  P   G +++   +  N F+++  Y++V V
Sbjct: 683 QFTPTHVGLQRLTVEVDCNMFQNLTNYKSVTV 714



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 25/61 (40%), Positives = 35/61 (57%), Gaps = 2/61 (3%)

Query: 5  LEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRN--RSFQPGLDNIIFVVE 62
          L +   D Q++RNN  HHT+ ++   L VRRGQ F + LYFR   R+F P L  +    +
Sbjct: 35 LGIKSCDFQAARNNEEHHTKALSSRRLFVRRGQPFTIILYFRAPVRAFLPALKKVALTAQ 94

Query: 63 T 63
          T
Sbjct: 95 T 95


>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
          Length = 1406

 Score = 35.4 bits (80), Expect = 0.16
 Identities = 54/219 (24%), Positives = 88/219 (40%), Gaps = 39/219 (17%)

Query: 30  HLLVRRGQAFNLTLYFRNRSFQPGLDNIIFVVETEDAVYLDSEPQRQEYVMNDYGFIYQG 89
           HL+  + + + + LY  +++    +    + +E  D +Y+   P +QE  +N        
Sbjct: 794 HLISLKIKPYKIELYQSSQNLG-FISASTWKIEKGDVIYIGGLPDKQETELNG------- 845

Query: 90  SKNWIRPCPWNYGQFEDKIIDICLKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINS 149
                       G F+  I D+  +L +++L F  +P  + +L    V V++  CA  NS
Sbjct: 846 ------------GFFKGCIQDV--RLNNQNLEFFPNPTNNASLNPVLVNVTQ-GCAGDNS 890

Query: 150 NDDNGVLNGNWSENYTDGAN---PAEWTGSVAILKQW-------NATGCQPVRYGQCWVF 199
              N   NG    +  D  +   PA  +G      QW       +   CQPV  G   + 
Sbjct: 891 CKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEEVQWCGFSPCPHGAQCQPVLQGFECIA 950

Query: 200 AAVM-----CTVMRCLGIPTRVITNFDSGHDT-DGNLII 232
            AV        + R  G  TR +TN   G  T D N+II
Sbjct: 951 NAVFNGQSGQILFRSNGNITRELTNITFGFRTRDANVII 989


>gi|154090979 hypothetical protein LOC57481 [Homo sapiens]
          Length = 1709

 Score = 32.7 bits (73), Expect = 1.1
 Identities = 31/124 (25%), Positives = 57/124 (45%), Gaps = 10/124 (8%)

Query: 324  WLVQGGKEQKLHQDTSSVGNFISTKSIQSDERDDITENYKYE-EGSLQERQVFLKALQKL 382
            W+    ++QK  +   SV   + TKS    + +  T+  KYE  GS  E Q      +K+
Sbjct: 1578 WITMAKQKQKSFKAHISVKE-LKTKSNAGADAE--TKEPKYEGAGSANENQP-----KKM 1629

Query: 383  KARSFHGSQRGAELQPSRPT-SLSQDSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDI 441
               S H  ++ A+++P +PT S+  ++ + L  P++        +L  K  +P    + +
Sbjct: 1630 FTSSVHKQEKTAQMKPPKPTKSVGFEAQKILQVPAMEKETKRSSTLPAKFQNPVEPIEPV 1689

Query: 442  CFVL 445
             F L
Sbjct: 1690 WFSL 1693


>gi|4507773 ubiquitin-conjugating enzyme E2D 1 [Homo sapiens]
          Length = 147

 Score = 31.6 bits (70), Expect = 2.3
 Identities = 26/80 (32%), Positives = 35/80 (43%), Gaps = 1/80 (1%)

Query: 411 SLHTPSLRPSDVVQVSLKFKLLDPP-NMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHD 469
           ++H P+  P    +++   K+  P  N    IC  +L    S      KV LS  SLL D
Sbjct: 53  TVHFPTDYPFKPPKIAFTTKIYHPNINSNGSICLDILRSQWSPALTVSKVLLSICSLLCD 112

Query: 470 GSPLSPFWQDTAFITLSPKE 489
            +P  P   D A I  S KE
Sbjct: 113 PNPDDPLVPDIAQIYKSDKE 132


>gi|5453952 beta isoform of regulatory subunit B56, protein
           phosphatase 2A [Homo sapiens]
          Length = 497

 Score = 31.2 bits (69), Expect = 3.1
 Identities = 26/107 (24%), Positives = 45/107 (42%), Gaps = 12/107 (11%)

Query: 308 YDTPFVFSMVNADC-------MSWLVQGGKEQKLHQDTSSVGNFIST-KSIQSDERDDIT 359
           ++  ++ S++  +C          L Q  KE       S + N + T   +     D++T
Sbjct: 381 WNNEYILSLIEDNCHTVLPAVFGTLYQVSKEHWNQTIVSLIYNVLKTFMEMNGKLFDELT 440

Query: 360 ENYKYE----EGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPT 402
            +YK E    +   QERQ   + L++L+ R   G+Q   E    R T
Sbjct: 441 ASYKLEKQQEQQKAQERQELWQGLEELRLRRLQGTQGAKEAPLQRLT 487


>gi|31541941 heat shock 70kDa protein 4-like [Homo sapiens]
          Length = 839

 Score = 30.8 bits (68), Expect = 4.0
 Identities = 13/25 (52%), Positives = 19/25 (76%)

Query: 359 TENYKYEEGSLQERQVFLKALQKLK 383
           TEN+ YE+G  Q +QV++  LQ+LK
Sbjct: 658 TENWLYEDGEDQPKQVYVDKLQELK 682


>gi|151101459 SAPS domain family, member 1 [Homo sapiens]
          Length = 881

 Score = 30.8 bits (68), Expect = 4.0
 Identities = 31/124 (25%), Positives = 54/124 (43%), Gaps = 17/124 (13%)

Query: 457 LKVNLSAQSLLHDGSP-LSPFWQDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRIS 515
           L+  +S+   LH   P LS F Q    + L P   K  P ++++   +  L   +L  + 
Sbjct: 307 LESTVSSVGALHALRPRLSCFHQ----LLLEPP--KLEPLQMTWGMLAPPLGNTRLHVVK 360

Query: 516 ALGEEKSSPEKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTV 575
            L    S+ +  L ++++ L  P+  ++          L    +F+N L  QVE CV T+
Sbjct: 361 LLASALSANDAALTHELLALDVPNTMLD----------LFFHYVFNNFLHAQVEGCVSTM 410

Query: 576 EGSG 579
              G
Sbjct: 411 LSLG 414


>gi|38327039 heat shock 70kDa protein 4 [Homo sapiens]
          Length = 840

 Score = 29.6 bits (65), Expect = 8.9
 Identities = 15/42 (35%), Positives = 24/42 (57%), Gaps = 6/42 (14%)

Query: 348 KSIQSDERDDIT------ENYKYEEGSLQERQVFLKALQKLK 383
           K +  D+R+  T      EN+ YE+G  Q +QV++  L +LK
Sbjct: 638 KFVSEDDRNSFTLKLEDTENWLYEDGEDQPKQVYVDKLAELK 679


>gi|118918407 spectrin repeat containing, nuclear envelope 2 isoform 5
            [Homo sapiens]
          Length = 6907

 Score = 29.6 bits (65), Expect = 8.9
 Identities = 25/90 (27%), Positives = 45/90 (50%), Gaps = 9/90 (10%)

Query: 298  AIKEGEVDLNYDTPFVFSMVNADCMSWLVQGGKEQKLHQDTSSVGNFISTKSIQSDERDD 357
            AI++ E++   +T  VF+  N +  +WLVQ   E K+ Q      +    + I+  ++D 
Sbjct: 5906 AIRKQEIEDRLNTWVVFNEKNKELCAWLVQ--MENKVLQ----TADISIEEMIEKLQKDC 5959

Query: 358  ITENYKYEEGSLQERQV---FLKALQKLKA 384
            + E   + E  LQ +Q+    +KA  K +A
Sbjct: 5960 MEEINLFSENKLQLKQMGDQLIKASNKSRA 5989


>gi|118918403 spectrin repeat containing, nuclear envelope 2 isoform 1
            [Homo sapiens]
          Length = 6885

 Score = 29.6 bits (65), Expect = 8.9
 Identities = 25/90 (27%), Positives = 45/90 (50%), Gaps = 9/90 (10%)

Query: 298  AIKEGEVDLNYDTPFVFSMVNADCMSWLVQGGKEQKLHQDTSSVGNFISTKSIQSDERDD 357
            AI++ E++   +T  VF+  N +  +WLVQ   E K+ Q      +    + I+  ++D 
Sbjct: 5906 AIRKQEIEDRLNTWVVFNEKNKELCAWLVQ--MENKVLQ----TADISIEEMIEKLQKDC 5959

Query: 358  ITENYKYEEGSLQERQV---FLKALQKLKA 384
            + E   + E  LQ +Q+    +KA  K +A
Sbjct: 5960 MEEINLFSENKLQLKQMGDQLIKASNKSRA 5989


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,901,819
Number of Sequences: 37866
Number of extensions: 1142112
Number of successful extensions: 2586
Number of sequences better than 10.0: 21
Number of HSP's better than 10.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 2526
Number of HSP's gapped (non-prelim): 37
length of query: 638
length of database: 18,247,518
effective HSP length: 109
effective length of query: 529
effective length of database: 14,120,124
effective search space: 7469545596
effective search space used: 7469545596
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.