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Search of human proteins with 4759146
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4759146 slit homolog 2 [Homo sapiens]
(1529 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4759146 slit homolog 2 [Homo sapiens] 3216 0.0
gi|11321571 slit homolog 3 [Homo sapiens] 2197 0.0
gi|188528675 slit homolog 1 [Homo sapiens] 2183 0.0
gi|24041035 notch 2 preproprotein [Homo sapiens] 226 2e-58
gi|4557679 jagged 1 precursor [Homo sapiens] 215 3e-55
gi|41327708 crumbs homolog 1 precursor [Homo sapiens] 210 1e-53
gi|148833508 notch1 preproprotein [Homo sapiens] 209 1e-53
gi|112420992 crumbs homolog 2 [Homo sapiens] 206 2e-52
gi|134244285 Notch homolog 3 [Homo sapiens] 204 4e-52
gi|21704279 jagged 2 isoform b precursor [Homo sapiens] 199 1e-50
gi|110735443 delta-like 1 [Homo sapiens] 199 2e-50
gi|55770876 notch4 preproprotein [Homo sapiens] 198 3e-50
gi|9506545 delta-like 4 protein precursor [Homo sapiens] 196 1e-49
gi|21704277 jagged 2 isoform a precursor [Homo sapiens] 196 1e-49
gi|148886654 polydom [Homo sapiens] 194 7e-49
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 181 6e-45
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 181 6e-45
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens] 178 3e-44
gi|122937283 6720455I24Rik homolog [Homo sapiens] 176 2e-43
gi|116235485 delta-notch-like EGF repeat-containing transmembran... 174 8e-43
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 164 5e-40
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 153 1e-36
gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens] 152 3e-36
gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens] 152 3e-36
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 150 9e-36
gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens] 149 2e-35
gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens] 149 2e-35
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 144 9e-34
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 141 4e-33
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 140 9e-33
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 3216 bits (8338), Expect = 0.0
Identities = 1529/1529 (100%), Positives = 1529/1529 (100%)
Query: 1 MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL 60
MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL
Sbjct: 1 MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL 60
Query: 61 DLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPE 120
DLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPE
Sbjct: 61 DLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPE 120
Query: 121 LLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVL 180
LLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVL
Sbjct: 121 LLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVL 180
Query: 181 TLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPS 240
TLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPS
Sbjct: 181 TLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPS 240
Query: 241 HLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPE 300
HLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPE
Sbjct: 241 HLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPE 300
Query: 301 TITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKI 360
TITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKI
Sbjct: 301 TITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKI 360
Query: 361 TELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLR 420
TELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLR
Sbjct: 361 TELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLR 420
Query: 421 AIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSA 480
AIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSA
Sbjct: 421 AIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSA 480
Query: 481 KEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRL 540
KEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRL
Sbjct: 481 KEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRL 540
Query: 541 NNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHK 600
NNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHK
Sbjct: 541 NNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHK 600
Query: 601 MFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLN 660
MFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLN
Sbjct: 601 MFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLN 660
Query: 661 LLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNS 720
LLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNS
Sbjct: 661 LLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNS 720
Query: 721 CSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLT 780
CSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLT
Sbjct: 721 CSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLT 780
Query: 781 LIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVV 840
LIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVV
Sbjct: 781 LIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVV 840
Query: 841 PEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTT 900
PEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTT
Sbjct: 841 PEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTT 900
Query: 901 PSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHA 960
PSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHA
Sbjct: 901 PSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHA 960
Query: 961 CISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNY 1020
CISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNY
Sbjct: 961 CISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNY 1020
Query: 1021 TCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDC 1080
TCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDC
Sbjct: 1021 TCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDC 1080
Query: 1081 QDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRI 1140
QDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRI
Sbjct: 1081 QDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRI 1140
Query: 1141 NEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYK 1200
NEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYK
Sbjct: 1141 NEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYK 1200
Query: 1201 GDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGN 1260
GDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGN
Sbjct: 1201 GDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGN 1260
Query: 1261 PKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDF 1320
PKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDF
Sbjct: 1261 PKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDF 1320
Query: 1321 QKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKC 1380
QKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKC
Sbjct: 1321 QKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKC 1380
Query: 1381 VHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSS 1440
VHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSS
Sbjct: 1381 VHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSS 1440
Query: 1441 GYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRR 1500
GYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRR
Sbjct: 1441 GYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRR 1500
Query: 1501 KYSFECTDGSSFVDEVEKVVKCGCTRCVS 1529
KYSFECTDGSSFVDEVEKVVKCGCTRCVS
Sbjct: 1501 KYSFECTDGSSFVDEVEKVVKCGCTRCVS 1529
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 2197 bits (5692), Expect = 0.0
Identities = 1016/1521 (66%), Positives = 1229/1521 (80%), Gaps = 18/1521 (1%)
Query: 11 LSLGLVLA-ILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITR 69
L+L L LA +L+ ACP +C+CS ++VDCHGL LR+VPR IPRN ERLDL+ NNITR
Sbjct: 16 LALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITR 75
Query: 70 ITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKL 129
ITK DFAGL++LRVL L +N++S IERGAFQDLK+LERLRLN+N LQ+ PELLF T KL
Sbjct: 76 ITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKL 135
Query: 130 YRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITR 189
RLDLSENQIQ IPRKAFRG D+KNLQLD N ISCIEDGAFRALRDLE+LTLNNNNI+R
Sbjct: 136 TRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISR 195
Query: 190 LSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAE 249
+ V SFNHMPK+RT RLHSN+LYCDCHLAWLSDWLRQR VG +T CM P HLRG NVA+
Sbjct: 196 ILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVAD 255
Query: 250 VQKREFVCSGHQSFMAPSCSV--LHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRL 307
VQK+E+VC S PSC+ + CP+ CTCSNNIVDCRGKGL EIP NLPE I EIRL
Sbjct: 256 VQKKEYVCPAPHS-EPPSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRL 314
Query: 308 EQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSL 367
EQN+IK IP GAF+ YKKL+RID+S NQIS++APDAFQGL+SL SLVLYGNKITE+ K L
Sbjct: 315 EQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGL 374
Query: 368 FEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHL 427
F+GL SLQLLLLNANKINCLRV+ FQDL NLNLLSLYDNKLQTI+KG F+PL++IQT+HL
Sbjct: 375 FDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHL 434
Query: 428 AQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIP 487
AQNPF+CDCHLKWLADYL NPIETSGARC+SPRRLANKRI QIKSKKFRCS
Sbjct: 435 AQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCS-------- 486
Query: 488 GTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTV 547
G+EDYRS+ S +CF DL CPEKCRCEGT VDCSNQKL +IP H+P+Y +LRLN+NE +V
Sbjct: 487 GSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSV 546
Query: 548 LEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLES 607
LEATGIFKKLP LRKIN SNNKI ++ EGAF+GA+ V E++LT N+LE V ++F+GL
Sbjct: 547 LEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSG 606
Query: 608 LKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFN 667
LKTLMLRSN I CV ND+F GLSSVRLLSLYDN+ITT+ PGAF TL SLST+NLL+NPFN
Sbjct: 607 LKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFN 666
Query: 668 CNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRC 727
CNC+LAWLG+WLRK+RIV+GNPRCQKP+FLKEIPIQDVAIQDFTCD GN+++SC RC
Sbjct: 667 CNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCD-GNEESSCQLSPRC 725
Query: 728 PTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNN 787
P +CTC++TVVRCSNKGL+ LP+G+P+DVTELYL+GN T VP+ELS +HLTLIDLSNN
Sbjct: 726 PEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNN 785
Query: 788 RISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFND 847
IS L+N +FSNM+ L TLILSYNRLRCIP F+GL+SLR+L+LHGNDIS VPEG+FND
Sbjct: 786 SISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFND 845
Query: 848 LSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTC 907
L++LSHLA+G NPL+CDC+++WLS+WVK+ YKEPGIARC+ P MAD+LLLTTP+ +F C
Sbjct: 846 LTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQC 905
Query: 908 QGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCK 967
+GPVD+NI+AKCN CLS+PCKN+GTC DPV+ YRC CPY +KG+DC VPI+ CI NPC+
Sbjct: 906 KGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQ 965
Query: 968 HGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPE 1027
HGGTCHL + +DGF C C GFEG+ CE+N DDCEDNDCENN+TCVDGINNY C+CPP
Sbjct: 966 HGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPN 1025
Query: 1028 YTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKN 1087
YTGELC+E +D C +LN CQH++KCI KGF C+C PGY G+ C+ D DDC +KC++
Sbjct: 1026 YTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRH 1085
Query: 1088 GAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQC 1147
GA C D +NGYTC CP+G+SG FCE PPMVL +TSPCD ++CQNGAQCIV EP C+C
Sbjct: 1086 GAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRC 1145
Query: 1148 LPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIA 1207
PG+ G +CEKL++VNF+ K+SY+++ SAKVRPQ NI+LQ+ATD+D+GILLYKGD D +A
Sbjct: 1146 PPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANISLQVATDKDNGILLYKGDNDPLA 1205
Query: 1208 VELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNL 1267
+ELY+G VR YD+ S P + +YSVET+NDG FH VEL+ L+Q+L+L VD G PK + L
Sbjct: 1206 LELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKL 1265
Query: 1268 SKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQT 1327
KQ + +SPLY+GG+P + +++LRQ + FHGCI + IN+ELQDF+ +P Q+
Sbjct: 1266 QKQPAVGINSPLYLGGIPTSTGLSALRQGTDRPLGGFHGCIHEVRINNELQDFKALPPQS 1325
Query: 1328 -GILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCL 1386
G+ PGC+ C VC HG C+ + CEC+ GW GPLCDQ DPCLG++C HG C+
Sbjct: 1326 LGVSPGCKSC--TVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCV 1383
Query: 1387 PINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDS 1446
SY CKC EG+GG LCD + D N C A KC HG+C +S G+PYC C G++G+
Sbjct: 1384 ATGT-SYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEH 1442
Query: 1447 CDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFEC 1506
C +E C G+ +R+ ++Q+GYA+C T KV +ECRGGC G QCC P RSKRRKY F+C
Sbjct: 1443 CQQENPCLGQVVREVIRRQKGYASCATASKVPIMECRGGC-GPQCCQPTRSKRRKYVFQC 1501
Query: 1507 TDGSSFVDEVEKVVKCGCTRC 1527
TDGSSFV+EVE+ ++CGC C
Sbjct: 1502 TDGSSFVEEVERHLECGCLAC 1522
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 2183 bits (5656), Expect = 0.0
Identities = 1002/1516 (66%), Positives = 1227/1516 (80%), Gaps = 6/1516 (0%)
Query: 15 LVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTD 74
L+ A ++ ACPA C+C+G+TVDCHG L+++P+NIPRNTERL+LNGNNITRI K D
Sbjct: 21 LLWAAAWRLGASACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKND 80
Query: 75 FAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDL 134
FAGL+ LRVLQLMEN+I +ERGAF D+KELERLRLNRN L + PELLF L RLDL
Sbjct: 81 FAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDL 140
Query: 135 SENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVAS 194
SEN IQAIPRKAFRGA D+KNLQLD NQISCIE+GAFRALR LEVLTLNNNNIT + V+S
Sbjct: 141 SENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSS 200
Query: 195 FNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKRE 254
FNHMPKLRTFRLHSN+L+CDCHLAWLS WLRQRP +GL+TQC GP+ LRG NVAEVQK E
Sbjct: 201 FNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSE 260
Query: 255 FVCSGH-QSFMAPSCSVLH--CPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNT 311
F CSG ++ P+C++ CPA CTCSN IVDCRGKGLT IP NLPET+TEIRLE N
Sbjct: 261 FSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNG 320
Query: 312 IKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGL 371
IK IPPGAFSPY+KLRRIDLSNNQI+E+APDAFQGLRSLNSLVLYGNKIT+LP+ +F GL
Sbjct: 321 IKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGL 380
Query: 372 FSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNP 431
++LQLLLLNANKINC+R DAFQDL NL+LLSLYDNK+Q++AKGTF+ LRAIQT+HLAQNP
Sbjct: 381 YTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNP 440
Query: 432 FICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTED 491
FICDC+LKWLAD+L TNPIETSGARC SPRRLANKRIGQIKSKKFRCSAKEQYFIPGTED
Sbjct: 441 FICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTED 500
Query: 492 YRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEAT 551
Y+ L+ +C +D+ CP KCRCE V+CS+ KL KIPE IPQ TAELRLNNNE ++LEAT
Sbjct: 501 YQ--LNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEAT 558
Query: 552 GIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTL 611
G+FKKL L+KIN SNNK+++IE+GAFEGA+ V+E+ LT+N+LE+++ MF+GL+ L+TL
Sbjct: 559 GMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTL 618
Query: 612 MLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCY 671
MLR+NRI+C+ NDSF GL +VRLLSLYDNQITTV+PGAFDTL SLSTLNLLANPFNCNC
Sbjct: 619 MLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQ 678
Query: 672 LAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTEC 731
LAWLG WLRK++IVTGNPRCQ P FL++IP+QDVA DF C++G ++ C P +CP EC
Sbjct: 679 LAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQEC 738
Query: 732 TCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRIST 791
CLDTVVRCSNK L+ LPKGIP++VTELYLDGNQFTLVP +LS +K+L L+DLSNN+IS+
Sbjct: 739 ACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISS 798
Query: 792 LSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSAL 851
LSN SF+NM+QL TLILSYN L+CIPP F GL+SLRLLSLHGNDIS + EG F D+++L
Sbjct: 799 LSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSL 858
Query: 852 SHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPV 911
SHLAIGANPLYCDC+++WLS WVK+ YKEPGIARCAGP +M KLLLTTP+KKF CQGP
Sbjct: 859 SHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDMEGKLLLTTPAKKFECQGPP 918
Query: 912 DVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGT 971
+ + AKC+ CLS+PC+N GTC++DP++ YRC CP G+KG+DC+V + +C S PC++GGT
Sbjct: 919 TLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGT 978
Query: 972 CHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGE 1031
CH +EGE+ F C C GFEG C VN DDC D+ C N CVDG+ NYTC CP +Y G+
Sbjct: 979 CHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGK 1038
Query: 1032 LCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHC 1091
CE+ +D C+ DLNPCQH+++C+ TP G +C+C PGY G++C + DDC+D++C+NGA C
Sbjct: 1039 ACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQC 1098
Query: 1092 TDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGY 1151
D VN Y+C+C EGYSG CE P + P+ SPC+ +CQNGA C+ + N P+CQCLPG+
Sbjct: 1099 MDEVNSYSCLCAEGYSGQLCEIPPHLPAPK-SPCEGTECQNGANCVDQGNRPVCQCLPGF 1157
Query: 1152 QGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVELY 1211
G +CEKL+SVNF+++++YLQ + P+ NITLQ++T ED+GILLY GD DHIAVELY
Sbjct: 1158 GGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVSTAEDNGILLYNGDNDHIAVELY 1217
Query: 1212 RGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQS 1271
+G VR SYD GS+P+SAIYS ETINDG FH VEL+A DQ ++LS+DGG+P + N K
Sbjct: 1218 QGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQMVNLSIDGGSPMTMDNFGKHY 1277
Query: 1272 TLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILP 1331
TLN ++PLYVGGMP N A+ R NGT FHGCIRNLYIN+ELQDF K M+ G++P
Sbjct: 1278 TLNSEAPLYVGGMPVDVNSAAFRLWQILNGTGFHGCIRNLYINNELQDFTKTQMKPGVVP 1337
Query: 1332 GCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAF 1391
GCEPC K C HG CQP++ G C C+ GW+G CDQ + PC G+KCVHG C+P++A
Sbjct: 1338 GCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDAL 1397
Query: 1392 SYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREI 1451
SYSC+C +G+ G LC++ L PC+ ++C HG C+ SG +C C G++G+ C++E
Sbjct: 1398 SYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQES 1457
Query: 1452 SCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGSS 1511
CRG+ +RD++Q Q+GYA CQTT+ +S +ECRG C G CC LR KRRK++FEC+DG+S
Sbjct: 1458 ECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCPGQGCCQGLRLKRRKFTFECSDGTS 1517
Query: 1512 FVDEVEKVVKCGCTRC 1527
F +EVEK KCGC C
Sbjct: 1518 FAEEVEKPTKCGCALC 1533
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 226 bits (575), Expect = 2e-58
Identities = 183/711 (25%), Positives = 271/711 (38%), Gaps = 128/711 (18%)
Query: 862 YCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTC---QGPVDVNILAK 918
+C+C + + + E C DK+ FTC G V+ +
Sbjct: 441 HCECLKGYAGPRCEMDINECHSDPCQNDATCLDKI------GGFTCLCMPGFKGVHCELE 494
Query: 919 CNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGE 978
N C SNPC N+G C D V+ ++C CP GF G C + I C S PC +G C
Sbjct: 495 INECQSNPCVNNGQC-VDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCI---DH 550
Query: 979 EDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLD 1038
+G+ C CA GF G CE N+D+C+ + C + C DGI++YTC+C P Y G +C +++D
Sbjct: 551 PNGYECQCATGFTGVLCEENIDNCDPDPCHHGQ-CQDGIDSYTCICNPGYMGAICSDQID 609
Query: 1039 FCAQDLNPCQHDSKCILTPKGFKCDC---------------------------------- 1064
C +PC +D +CI G++C+C
Sbjct: 610 ECYS--SPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYS 667
Query: 1065 ---TPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEG------YSGLFCEFSP 1115
+PG+ G+ C+ID D+C N C+ GA C + VNG+ CICPEG YS + S
Sbjct: 668 CVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSN 727
Query: 1116 PMVLPR------------------------TSPCDNFDCQNGAQCIVRINEPICQCLPGY 1151
P + + C + CQNG C +N C C G+
Sbjct: 728 PCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGF 787
Query: 1152 QGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVELY 1211
+G C+ +N + P + D+ SG + V Y
Sbjct: 788 KGYNCQ-------VNIDECASNPC--------LNQGTCFDDISGYTCH-------CVLPY 825
Query: 1212 RGRVRASYDTGSHPASAIYSVETINDGNFHIVELLAL----DQSLSLSVDGGNPKIITN- 1266
G+ + P + NF L Q ++ +D K N
Sbjct: 826 TGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNH 885
Query: 1267 ---LSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKV 1323
+ Q + + P GM + ++ P QNG S + N + L F
Sbjct: 886 GLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGV-NTFSCLCLPGFTGD 944
Query: 1324 PMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHG 1383
QT + C + C +G +TC+CQ G+ G C+ N+ C + C +G
Sbjct: 945 KCQTDM----NECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINE-CTESSCFNG 999
Query: 1384 TCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYT 1443
S+SC C G G C E N C + C + + GLG C C GYT
Sbjct: 1000 GTCVDGINSFSCLCPVGFTGSFCLHE---INECSSHPCLNEGTCVDGLGTYRCSCPLGYT 1056
Query: 1444 GDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGP 1494
G +C ++ + C K S+ C G AG C P
Sbjct: 1057 GKNCQTLVNLCSR------SPCKNKGTCVQKKAESQCLCPSGWAGAYCDVP 1101
Score = 216 bits (551), Expect = 1e-55
Identities = 112/319 (35%), Positives = 160/319 (50%), Gaps = 45/319 (14%)
Query: 859 NPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPVDVN---I 915
N C C + ++ E + C G D + F+C PV
Sbjct: 969 NSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGI------NSFSCLCPVGFTGSFC 1022
Query: 916 LAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLK 975
L + N C S+PC N+GTC D + YRC+CP G+ G++C ++ C +PCK+ GTC K
Sbjct: 1023 LHEINECSSHPCLNEGTC-VDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQK 1081
Query: 976 EGEEDGFWCICADGFEGENCEVNVDDCE----------DNDCENNSTCVDGINNYTCLCP 1025
+ E C+C G+ G C+V C+ ++ C+++ C++ N + C CP
Sbjct: 1082 KAESQ---CLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCP 1138
Query: 1026 PEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKC 1085
YTG CEE+LD CA NPCQH + C G++C+C PGY G +C+ + D+CQ+ C
Sbjct: 1139 LGYTGSYCEEQLDECAS--NPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPC 1196
Query: 1086 KNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFD-------CQNGAQCIV 1138
+NG C D VN + C CP G GL CE +N D C NG QC+
Sbjct: 1197 QNGGTCIDLVNHFKCSCPPGTRGLLCE-------------ENIDDCARGPHCLNGGQCMD 1243
Query: 1139 RINEPICQCLPGYQGEKCE 1157
RI C+CLPG+ GE+CE
Sbjct: 1244 RIGGYSCRCLPGFAGERCE 1262
Score = 204 bits (518), Expect = 7e-52
Identities = 107/336 (31%), Positives = 154/336 (45%), Gaps = 57/336 (16%)
Query: 863 CDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPVD-VNILAKCNP 921
C C W D + A C D++ F+C P +L +
Sbjct: 324 CVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVA------SFSCMCPEGKAGLLCHLDD 377
Query: 922 -CLSNPCKNDGTCNSDPVDF-YRCTCPYGFKGQDCDVPIHACI---SNPCKHGGTCHLKE 976
C+SNPC C+++P++ Y CTCP G+KG DC + C SNPC+H G C +
Sbjct: 378 ACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTD 437
Query: 977 G---------------EED--------------------GFWCICADGFEGENCEVNVDD 1001
G E D GF C+C GF+G +CE+ +++
Sbjct: 438 GAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINE 497
Query: 1002 CEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFK 1061
C+ N C NN CVD +N + CLCPP +TG +C+ +D C+ PC + +KCI P G++
Sbjct: 498 CQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSS--TPCLNGAKCIDHPNGYE 555
Query: 1062 CDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPR 1121
C C G+ G C+ + D+C + C +G C D ++ YTCIC GY G C +
Sbjct: 556 CQCATGFTGVLCEENIDNCDPDPCHHG-QCQDGIDSYTCICNPGYMGAICS-------DQ 607
Query: 1122 TSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCE 1157
C + C N +CI +N C C PG G CE
Sbjct: 608 IDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCE 643
Score = 199 bits (505), Expect = 2e-50
Identities = 98/264 (37%), Positives = 134/264 (50%), Gaps = 17/264 (6%)
Query: 899 TTPSKKFTCQ---GPVDVNILAKCNPC-LSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDC 954
TT + +F+C+ G N C + C++ GTC + P Y+C CP GF GQ C
Sbjct: 160 TTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGS-YQCQCPQGFTGQYC 218
Query: 955 DVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCV 1014
D C +PC +GGTC ++ + F C C GFEG CE N+DDC ++ C+N CV
Sbjct: 219 DSLYVPCAPSPCVNGGTC--RQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCV 276
Query: 1015 DGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCD 1074
DG+N Y C CPP++TG+ C E +D C N CQ+ C G+ C C G+ G+ C
Sbjct: 277 DGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCS 336
Query: 1075 IDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGA 1134
+ DDC C G+ C D V ++C+CPEG +GL C C + C GA
Sbjct: 337 ENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLD--------DACISNPCHKGA 388
Query: 1135 QCIVR--INEPICQCLPGYQGEKC 1156
C + IC C GY+G C
Sbjct: 389 LCDTNPLNGQYICTCPQGYKGADC 412
Score = 188 bits (478), Expect = 3e-47
Identities = 101/288 (35%), Positives = 129/288 (44%), Gaps = 63/288 (21%)
Query: 920 NPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEE 979
N CLS PCKN GTC SD V+ Y C C GF G C+ I+ C + C +GGTC
Sbjct: 951 NECLSEPCKNGGTC-SDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTC------V 1003
Query: 980 DG---FWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEK 1036
DG F C+C GF G C +++C + C N TCVDG+ Y C CP YTG+ C+
Sbjct: 1004 DGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTL 1063
Query: 1037 LDFCA-----------------QDLNP-----------------------------CQHD 1050
++ C+ Q L P CQH
Sbjct: 1064 VNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHS 1123
Query: 1051 SKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLF 1110
CI C C GY G +C+ D+C N C++GA C+D + GY C C GY G+
Sbjct: 1124 GVCINAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVN 1183
Query: 1111 CEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEK 1158
CE+ C N CQNG CI +N C C PG +G CE+
Sbjct: 1184 CEYE-------VDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEE 1224
Score = 183 bits (465), Expect = 1e-45
Identities = 108/372 (29%), Positives = 158/372 (42%), Gaps = 98/372 (26%)
Query: 881 PGIARCAGP----GEMADKLLLT-TPSKKF---TCQGPVDVNILAKCNP----------- 921
PG +C P G+ D L + PS TC+ D C P
Sbjct: 202 PGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNI 261
Query: 922 --CLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNP--CKHGGTCHLKEG 977
C ++ C+N G C D V+ Y C CP + GQ C + C+ P C++GGTC + G
Sbjct: 262 DDCPNHRCQNGGVC-VDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNG 320
Query: 978 EEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCP------------ 1025
G+ C+C +G+ G++C N+DDC C STC+D + +++C+CP
Sbjct: 321 ---GYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDD 377
Query: 1026 --------------------------PE-YTGELCEEKLDFCAQ-DLNPCQHDSKCILTP 1057
P+ Y G C E +D CA + NPC+H KC+ T
Sbjct: 378 ACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTD 437
Query: 1058 KGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCE----- 1112
F C+C GY G C++D ++C + C+N A C D + G+TC+C G+ G+ CE
Sbjct: 438 GAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINE 497
Query: 1113 --------------------------FSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQ 1146
F+ P+ C + C NGA+CI N CQ
Sbjct: 498 CQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQ 557
Query: 1147 CLPGYQGEKCEK 1158
C G+ G CE+
Sbjct: 558 CATGFTGVLCEE 569
Score = 179 bits (453), Expect = 2e-44
Identities = 97/301 (32%), Positives = 151/301 (50%), Gaps = 17/301 (5%)
Query: 862 YCDCNMQWLSDWVKSEYKEPGIA-RCAGPGEMADKLLLTTPSKKFTCQGPVDVNILAKCN 920
YC C +L ++ ++++P RC G + +L + + + + +
Sbjct: 50 YCKCPEGFLGEYC--QHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSH 107
Query: 921 PC-LSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEE 979
PC +S PC N GTC+ D Y CTC GF G++C AC+S+PC +G TC +
Sbjct: 108 PCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGSTCTTVANQ- 165
Query: 980 DGFWCICADGFEGENCEVNVDDCE-DNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLD 1038
F C C GF G+ CE +V++C+ C++ TC++ +Y C CP +TG+ C+
Sbjct: 166 --FSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYV 223
Query: 1039 FCAQDLNPCQHDSKCILTPK-GFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNG 1097
CA +PC + C T F+C+C PG+ G C+ + DDC +++C+NG C D VN
Sbjct: 224 PCAP--SPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNT 281
Query: 1098 YTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCE 1157
Y C CP ++G FC L + + CQNG C R C C+ G+ G+ C
Sbjct: 282 YNCRCPPQWTGQFCTEDVDECLLQPNA-----CQNGGTCANRNGGYGCVCVNGWSGDDCS 336
Query: 1158 K 1158
+
Sbjct: 337 E 337
Score = 164 bits (414), Expect = 8e-40
Identities = 91/266 (34%), Positives = 121/266 (45%), Gaps = 36/266 (13%)
Query: 922 CLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDG 981
C SNPC++ TC SD + YRC C G++G +C+ + C + PC++GGTC +
Sbjct: 1153 CASNPCQHGATC-SDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCI---DLVNH 1208
Query: 982 FWCICADGFEGENCEVNVDDCEDND-CENNSTCVDGINNYTCLCPPEYTGELCEEKLDFC 1040
F C C G G CE N+DDC C N C+D I Y+C C P + GE CE ++ C
Sbjct: 1209 FKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINEC 1268
Query: 1041 AQDLNPCQHDSK--CILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVN-- 1096
NPC + CI + C C + G HC+ D C C NG C A N
Sbjct: 1269 LS--NPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMP 1326
Query: 1097 -GYTCICPEGYSGLFCEFSPPMVLPR----------------------TSPCDNFDCQNG 1133
G+ C CP G+SG C+ S V R S C + CQ+G
Sbjct: 1327 DGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHG 1386
Query: 1134 AQCIVRINEPI--CQCLPGYQGEKCE 1157
C + P CQC P + G +CE
Sbjct: 1387 GSCHPQRQPPYYSCQCAPPFSGSRCE 1412
Score = 111 bits (278), Expect = 5e-24
Identities = 69/217 (31%), Positives = 97/217 (44%), Gaps = 25/217 (11%)
Query: 954 CDVPIHACISN----PCKHGGTC---HLKEGEEDGFWCICADGFEGENCEVNVDDCEDND 1006
C P HA PC + G C H G +C C +GF GE C+ + D CE N
Sbjct: 19 CAAPAHALQCRDGYEPCVNEGMCVTYHNGTG-----YCKCPEGFLGEYCQ-HRDPCEKNR 72
Query: 1007 CENNSTCVDG--INNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKC-ILTPKGFKCD 1063
C+N TCV + TC C +TGE C+ PC + C +L+ ++C
Sbjct: 73 CQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECT 132
Query: 1064 CTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTS 1123
C G+ G+ C D C + C NG+ CT N ++C C G++G CE +
Sbjct: 133 CQVGFTGKECQWT-DACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETD-------VN 184
Query: 1124 PCD-NFDCQNGAQCIVRINEPICQCLPGYQGEKCEKL 1159
CD CQ+G C+ CQC G+ G+ C+ L
Sbjct: 185 ECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSL 221
Score = 103 bits (257), Expect = 1e-21
Identities = 72/247 (29%), Positives = 97/247 (39%), Gaps = 42/247 (17%)
Query: 920 NPCLSNPCKNDGTCNSDPV-DFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGE 978
N CLSNPC ++G+ + + + Y C C F G+ C+ + C PC +GGTC +
Sbjct: 1266 NECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNM 1325
Query: 979 EDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLD 1038
DGF C C GF G C+ C C CV + C CP CE
Sbjct: 1326 PDGFICRCPPGFSGARCQ---SSCGQVKCRKGEQCVHTASGPRCFCPSPRD---CESG-- 1377
Query: 1039 FCAQDLNPCQHDSKCI--LTPKGFKCDCTPGYVGEHCDI-------DFDDCQDNKCKNGA 1089
CA +PCQH C P + C C P + G C++ C C + A
Sbjct: 1378 -CAS--SPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKA 1434
Query: 1090 H---CTDAVNGYTCICPEGYSGLFCE-----FSPPM-----------VLPRTSPC--DNF 1128
C +A N + C G L E S P+ L T C DNF
Sbjct: 1435 RDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVECLFDNF 1494
Query: 1129 DCQNGAQ 1135
+CQ ++
Sbjct: 1495 ECQGNSK 1501
Score = 72.8 bits (177), Expect = 2e-12
Identities = 56/209 (26%), Positives = 84/209 (40%), Gaps = 22/209 (10%)
Query: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVH-GTCLPINAFS 1392
+ C CA+G+ + F+C+C G+ G C+ N+ + C H GTCL + S
Sbjct: 146 DACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPG-S 204
Query: 1393 YSCKCLEGHGGVLCDEEEDLFNPCQAIKCKH-GKCRLSGLGQPYCECSSGYTGDSCDREI 1451
Y C+C +G G CD L+ PC C + G CR +G C C G+ G +C+R I
Sbjct: 205 YQCQCPQGFTGQYCD---SLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNI 261
Query: 1452 -SCRGERIRDYYQKQQGYAA--CQTTKKVSRLECR----------GGCAGGQCCGPLRSK 1498
C R ++ G C+ + + C C G C ++
Sbjct: 262 DDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCA---NR 318
Query: 1499 RRKYSFECTDGSSFVDEVEKVVKCGCTRC 1527
Y C +G S D E + C C
Sbjct: 319 NGGYGCVCVNGWSGDDCSENIDDCAFASC 347
Score = 72.4 bits (176), Expect = 3e-12
Identities = 42/120 (35%), Positives = 58/120 (48%), Gaps = 11/120 (9%)
Query: 1341 CAHGTCQPSSQ-----AGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFS--Y 1393
CA +C P S A F+C C EG G LC +D C+ N C G N + Y
Sbjct: 342 CAFASCTPGSTCIDRVASFSCMCPEGKAGLLC--HLDDACISNPCHKGALCDTNPLNGQY 399
Query: 1394 SCKCLEGHGGVLCDEEEDLFNPCQAIKCKH-GKCRLSGLGQPYCECSSGYTGDSCDREIS 1452
C C +G+ G C E+ D + C+H GKC ++ G +CEC GY G C+ +I+
Sbjct: 400 ICTCPQGYKGADCTEDVDECAMANSNPCEHAGKC-VNTDGAFHCECLKGYAGPRCEMDIN 458
Score = 71.6 bits (174), Expect = 5e-12
Identities = 51/182 (28%), Positives = 74/182 (40%), Gaps = 24/182 (13%)
Query: 1335 PCHKKVCAHGT-CQPSSQ-AGFTCECQEGWMGPLCDQRTNDPCLGNKCV-HGTCLPINAF 1391
PC C + C+ S +TC C GW G C D C+ C+ HG C
Sbjct: 836 PCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDI-DECISKPCMNHGLCHNTQG- 893
Query: 1392 SYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREI 1451
SY C+C G G+ C+E+ D C A C++G + G+ C C G+TGD C ++
Sbjct: 894 SYMCECPPGFSGMDCEEDID---DCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDM 950
Query: 1452 S-CRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGS 1510
+ C E ++ C +C+ G G C + ECT+ S
Sbjct: 951 NECLSEPCKN-------GGTCSDYVNSYTCKCQAGFDGVHCENNIN--------ECTESS 995
Query: 1511 SF 1512
F
Sbjct: 996 CF 997
Score = 71.2 bits (173), Expect = 7e-12
Identities = 38/106 (35%), Positives = 52/106 (49%), Gaps = 6/106 (5%)
Query: 1344 GTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGHGG 1403
GTC S+ + C CQ G+ G C + D CL + C +G+ A +SCKCL G G
Sbjct: 119 GTCHMLSRDTYECTCQVGFTGKEC--QWTDACLSHPCANGSTCTTVANQFSCKCLTGFTG 176
Query: 1404 VLCDEEEDLFNPCQAI-KCKHGKCRLSGLGQPYCECSSGYTGDSCD 1448
C+ + N C C+HG L+ G C+C G+TG CD
Sbjct: 177 QKCETD---VNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCD 219
Score = 69.3 bits (168), Expect = 3e-11
Identities = 45/153 (29%), Positives = 61/153 (39%), Gaps = 10/153 (6%)
Query: 1341 CAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEG 1400
C +G + G+ C C GW G C + +D C C G+ S+SC C EG
Sbjct: 309 CQNGGTCANRNGGYGCVCVNGWSGDDCSENIDD-CAFASCTPGSTCIDRVASFSCMCPEG 367
Query: 1401 HGGVLCD-EEEDLFNPCQAIKCKHGKCRLSGL-GQPYCECSSGYTGDSCDREISCRGERI 1458
G+LC ++ + NPC K C + L GQ C C GY G C ++ E
Sbjct: 368 KAGLLCHLDDACISNPCH----KGALCDTNPLNGQYICTCPQGYKGADCTEDVD---ECA 420
Query: 1459 RDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
+ C T EC G AG +C
Sbjct: 421 MANSNPCEHAGKCVNTDGAFHCECLKGYAGPRC 453
Score = 67.8 bits (164), Expect = 8e-11
Identities = 37/123 (30%), Positives = 59/123 (47%), Gaps = 8/123 (6%)
Query: 1334 EPCHKKVCAHG-TCQPSSQAG-FTCECQEGWMGPLCDQRTNDPC-LGNKCVH-GTCLPIN 1389
+PC K C +G TC + G TC C G+ G C T+ PC + C++ GTC ++
Sbjct: 66 DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLS 125
Query: 1390 AFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDR 1449
+Y C C G G C + C + C +G + Q C+C +G+TG C+
Sbjct: 126 RDTYECTCQVGFTGKECQWTD----ACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCET 181
Query: 1450 EIS 1452
+++
Sbjct: 182 DVN 184
Score = 64.3 bits (155), Expect = 9e-10
Identities = 43/165 (26%), Positives = 64/165 (38%), Gaps = 21/165 (12%)
Query: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVH-GTCLPINAFS 1392
+ C C HG G+ CEC G+ G C+ D C C + GTC+ +
Sbjct: 1151 DECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEV-DECQNQPCQNGGTCIDL-VNH 1208
Query: 1393 YSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREIS 1452
+ C C G G+LC EE++ + + C +G + +G C C G+ G+ C+ +I+
Sbjct: 1209 FKCSCPPGTRGLLC--EENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDIN 1266
Query: 1453 ------CRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
C E D Q Y CR G C
Sbjct: 1267 ECLSNPCSSEGSLDCIQLTNDYLCV----------CRSAFTGRHC 1301
Score = 62.4 bits (150), Expect = 3e-09
Identities = 37/121 (30%), Positives = 58/121 (47%), Gaps = 8/121 (6%)
Query: 1333 CEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVH-GTCLPINAF 1391
C + C H ++ F CEC +G+ GP C+ N+ C + C + TCL
Sbjct: 419 CAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINE-CHSDPCQNDATCLD-KIG 476
Query: 1392 SYSCKCLEGHGGVLCDEEEDLFNPCQAIKC-KHGKCRLSGLGQPYCECSSGYTGDSCDRE 1450
++C C+ G GV C+ E N CQ+ C +G+C + + + C C G+TG C +
Sbjct: 477 GFTCLCMPGFKGVHCELE---INECQSNPCVNNGQC-VDKVNRFQCLCPPGFTGPVCQID 532
Query: 1451 I 1451
I
Sbjct: 533 I 533
Score = 62.4 bits (150), Expect = 3e-09
Identities = 44/159 (27%), Positives = 66/159 (41%), Gaps = 15/159 (9%)
Query: 1340 VCAH-GTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCL 1398
+C H G C + + C+C G+ G C+++ D C N C HG Y C+C+
Sbjct: 1119 LCQHSGVCINAGNTHY-CQCPLGYTGSYCEEQL-DECASNPCQHGATCSDFIGGYRCECV 1176
Query: 1399 EGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREISCRGERI 1458
G+ GV C+ E D CQ C++G + + C C G G C+ E I
Sbjct: 1177 PGYQGVNCEYEVD---ECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCE-------ENI 1226
Query: 1459 RDYYQKQQGYAACQTTKKVSRLECR--GGCAGGQCCGPL 1495
D + Q ++ CR G AG +C G +
Sbjct: 1227 DDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDI 1265
Score = 60.1 bits (144), Expect = 2e-08
Identities = 37/118 (31%), Positives = 49/118 (41%), Gaps = 7/118 (5%)
Query: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSY 1393
+ C + C +G F C C G G LC++ +D G C++G Y
Sbjct: 1189 DECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGY 1248
Query: 1394 SCKCLEGHGGVLC--DEEEDLFNPCQAIKCKHGKCRLSGLGQPY-CECSSGYTGDSCD 1448
SC+CL G G C D E L NPC + G L Y C C S +TG C+
Sbjct: 1249 SCRCLPGFAGERCEGDINECLSNPCSS----EGSLDCIQLTNDYLCVCRSAFTGRHCE 1302
Score = 57.8 bits (138), Expect = 8e-08
Identities = 34/122 (27%), Positives = 58/122 (47%), Gaps = 12/122 (9%)
Query: 1335 PCHKKVCAHGTCQPSSQAG-FTCECQEGWMGPLCDQRTNDPCLGNK--CVH-GTCLPINA 1390
PCHK C + G + C C +G+ G C + ++ + N C H G C+ +
Sbjct: 383 PCHKGAL----CDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDG 438
Query: 1391 FSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDRE 1450
++ C+CL+G+ G C+ + N C + C++ L +G C C G+ G C+ E
Sbjct: 439 -AFHCECLKGYAGPRCEMD---INECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELE 494
Query: 1451 IS 1452
I+
Sbjct: 495 IN 496
Score = 57.4 bits (137), Expect = 1e-07
Identities = 42/164 (25%), Positives = 60/164 (36%), Gaps = 19/164 (11%)
Query: 1332 GCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAF 1391
G EPC + G C C+C EG++G C R DPC N+C +G A
Sbjct: 31 GYEPCVNE----GMCVTYHNGTGYCKCPEGFLGEYCQHR--DPCEKNRCQNGGTCVAQAM 84
Query: 1392 --SYSCKCLEGHGGVLCDEEEDLFNPCQAIK--CKHGKCRLSGLGQPYCECSSGYTGDSC 1447
+C+C G G C + +PC + G C + C C G+TG C
Sbjct: 85 LGKATCRCASGFTGEDC--QYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC 142
Query: 1448 DREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
+C + + C T +C G G +C
Sbjct: 143 QWTDACLSHPCAN-------GSTCTTVANQFSCKCLTGFTGQKC 179
Score = 47.8 bits (112), Expect = 8e-05
Identities = 27/98 (27%), Positives = 47/98 (47%), Gaps = 20/98 (20%)
Query: 1357 ECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPC 1416
+C++G+ +PC+ G C+ + + CKC EG G C + PC
Sbjct: 27 QCRDGY----------EPCVNE----GMCVTYHNGTGYCKCPEGFLGEYCQHRD----PC 68
Query: 1417 QAIKCKHGKCRLSG--LGQPYCECSSGYTGDSCDREIS 1452
+ +C++G ++ LG+ C C+SG+TG+ C S
Sbjct: 69 EKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTS 106
Score = 45.1 bits (105), Expect = 5e-04
Identities = 31/121 (25%), Positives = 46/121 (38%), Gaps = 16/121 (13%)
Query: 1354 FTCECQEGWMGPLCDQRTNDPCLGNKCVHG-TCLPINAF--SYSCKCLEGHGGVLCDEEE 1410
+ C C+ + G C+ D C C++G TC + + C+C G G C
Sbjct: 1288 YLCVCRSAFTGRHCETFV-DVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSS- 1345
Query: 1411 DLFNPCQAIKCKHGKCRLSGLGQPYC------ECSSGYTGDSCDREISCRGERIRDYYQK 1464
C +KC+ G+ + P C +C SG C SC +R YY
Sbjct: 1346 -----CGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCHPQRQPPYYSC 1400
Query: 1465 Q 1465
Q
Sbjct: 1401 Q 1401
Score = 42.0 bits (97), Expect = 0.005
Identities = 32/120 (26%), Positives = 46/120 (38%), Gaps = 22/120 (18%)
Query: 1336 CHKKVCAHG-TCQPSSQA--GFTCECQEGWMGPLCDQRTND-PC-LGNKCVHGTCLPINA 1390
C + C +G TC +S GF C C G+ G C C G +CVH P
Sbjct: 1308 CPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGP--- 1364
Query: 1391 FSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPY--CECSSGYTGDSCD 1448
+C C D + C + C+HG PY C+C+ ++G C+
Sbjct: 1365 -----RC-------FCPSPRDCESGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCE 1412
Score = 34.7 bits (78), Expect = 0.73
Identities = 21/85 (24%), Positives = 31/85 (36%), Gaps = 13/85 (15%)
Query: 1415 PCQAIKCKHG--KCRLSGL------GQPYCECSSGYTGDSCDREISCRGERIRDYYQKQQ 1466
P A++C+ G C G+ G YC+C G+ G+ C C R ++
Sbjct: 22 PAHALQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQN-----G 76
Query: 1467 GYAACQTTKKVSRLECRGGCAGGQC 1491
G Q + C G G C
Sbjct: 77 GTCVAQAMLGKATCRCASGFTGEDC 101
>gi|4557679 jagged 1 precursor [Homo sapiens]
Length = 1218
Score = 215 bits (547), Expect = 3e-55
Identities = 93/269 (34%), Positives = 138/269 (51%), Gaps = 45/269 (16%)
Query: 926 PCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCI 985
PC N GTC++ D Y+C+CP G+ G +C++ HAC+S+PC + G+C + GF C
Sbjct: 305 PCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSC---KETSLGFECE 361
Query: 986 CADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQD-- 1043
C+ G+ G C N+DDC N+C + TC D +N + C+CPP++TG+ C+ + C
Sbjct: 362 CSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPC 421
Query: 1044 ---------------------------------LNPCQHDSKCILTPKGFKCDCTPGYVG 1070
L CQ+D+ C G++C C PGY G
Sbjct: 422 VNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAG 481
Query: 1071 EHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDC 1130
+HC+ D D+C N C NG HC + +N + C+CP G+SG C+ C+ C
Sbjct: 482 DHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLD-------IDYCEPNPC 534
Query: 1131 QNGAQCIVRINEPICQCLPGYQGEKCEKL 1159
QNGAQC R ++ C+C Y+G+ C L
Sbjct: 535 QNGAQCYNRASDYFCKCPEDYEGKNCSHL 563
Score = 175 bits (444), Expect = 3e-43
Identities = 87/260 (33%), Positives = 127/260 (48%), Gaps = 17/260 (6%)
Query: 904 KFTC---QGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHA 960
KFTC +G N C SNPC+N GTC D V+ Y+C C G++G C+ I+
Sbjct: 612 KFTCDCNKGFTGTYCHENINDCESNPCRNGGTC-IDGVNSYKCICSDGWEGAYCETNIND 670
Query: 961 CISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNY 1020
C NPC +GGTC + F+C C +G++G+ C C++ C N TC D + +
Sbjct: 671 CSQNPCHNGGTCRDLVND---FYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAF 727
Query: 1021 TCLCPPEYTGELCE-EKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDD 1079
C+CP + G C + C NPC + C++ + F C C G+ G C + +D
Sbjct: 728 KCMCPGGWEGTTCNIARNSSCLP--NPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTND 785
Query: 1080 CQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVR 1139
C + C N C D N Y C C G++G C + + C + C GA C+
Sbjct: 786 CSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRIN-------INECQSSPCAFGATCVDE 838
Query: 1140 INEPICQCLPGYQGEKCEKL 1159
IN C C PG+ G KC+++
Sbjct: 839 INGYRCVCPPGHSGAKCQEV 858
Score = 169 bits (429), Expect = 1e-41
Identities = 92/284 (32%), Positives = 131/284 (46%), Gaps = 21/284 (7%)
Query: 863 CDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQ-GPVDVNILAKCNP 921
CDCN + + + C G D + S K C G N
Sbjct: 615 CDCNKGFTGTYCHENINDCESNPCRNGGTCIDGV----NSYKCICSDGWEGAYCETNIND 670
Query: 922 CLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDG 981
C NPC N GTC DFY C C G+KG+ C C C +GGTC+ E D
Sbjct: 671 CSQNPCHNGGTCRDLVNDFY-CDCKNGWKGKTCHSRDSQCDEATCNNGGTCY---DEGDA 726
Query: 982 FWCICADGFEGENCEV-NVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFC 1040
F C+C G+EG C + C N C N TCV ++TC+C + G +C + + C
Sbjct: 727 FKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDC 786
Query: 1041 AQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTC 1100
+ +PC + C+ ++C+C PG+ G C I+ ++CQ + C GA C D +NGY C
Sbjct: 787 SP--HPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRC 844
Query: 1101 ICPEGYSGLFCE-------FSPPMVLPRTSPCDNFDCQNGAQCI 1137
+CP G+SG C+ + V+P + D+ DC N QC+
Sbjct: 845 VCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDD-DC-NTCQCL 886
Score = 165 bits (417), Expect = 4e-40
Identities = 92/328 (28%), Positives = 133/328 (40%), Gaps = 47/328 (14%)
Query: 859 NPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKL-----LLTTPSKKFTCQGPVDV 913
N C C + D + + E C G +++ L T CQ +D
Sbjct: 469 NGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDY 528
Query: 914 NILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCH 973
C NPC+N C + D++ C CP ++G++C C + PC+ +C
Sbjct: 529 --------CEPNPCQNGAQCYNRASDYF-CKCPEDYEGKNCSHLKDHCRTTPCEVIDSCT 579
Query: 974 LKEGEEDG-------------------------FWCICADGFEGENCEVNVDDCEDNDCE 1008
+ D F C C GF G C N++DCE N C
Sbjct: 580 VAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCR 639
Query: 1009 NNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGY 1068
N TC+DG+N+Y C+C + G CE ++ C+Q NPC + C F CDC G+
Sbjct: 640 NGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQ--NPCHNGGTCRDLVNDFYCDCKNGW 697
Query: 1069 VGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNF 1128
G+ C C + C NG C D + + C+CP G+ G C + R S C
Sbjct: 698 KGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCN------IARNSSCLPN 751
Query: 1129 DCQNGAQCIVRINEPICQCLPGYQGEKC 1156
C NG C+V C C G++G C
Sbjct: 752 PCHNGGTCVVNGESFTCVCKEGWEGPIC 779
Score = 81.6 bits (200), Expect = 5e-15
Identities = 57/192 (29%), Positives = 81/192 (42%), Gaps = 22/192 (11%)
Query: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSY 1393
+PCH + G+C+ +S GF CEC GW GP C +D C N C HG +
Sbjct: 343 DPCHNR----GSCKETS-LGFECECSPGWTGPTCSTNIDD-CSPNNCSHGGTCQDLVNGF 396
Query: 1394 SCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREIS- 1452
C C G C + N C+A C + K + + YC+C G+ G +CD I+
Sbjct: 397 KCVCPPQWTGKTCQLDA---NECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININD 453
Query: 1453 CRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGSSF 1512
C G+ D A+C+ R C G AG C R S C +G
Sbjct: 454 CLGQCQND--------ASCRDLVNGYRCICPPGYAGDHC---ERDIDECASNPCLNGGHC 502
Query: 1513 VDEVEKVVKCGC 1524
+E+ + +C C
Sbjct: 503 QNEINR-FQCLC 513
Score = 77.0 bits (188), Expect = 1e-13
Identities = 59/185 (31%), Positives = 80/185 (43%), Gaps = 24/185 (12%)
Query: 1335 PCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVH-GTCLPINAFSY 1393
PCH GTC + ++ FTC C+EGW GP+C Q TND C + C + GTC+ + + Y
Sbjct: 752 PCHNG----GTCVVNGES-FTCVCKEGWEGPICAQNTND-CSPHPCYNSGTCVDGDNW-Y 804
Query: 1394 SCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREISC 1453
C+C G G C N CQ+ C G + + C C G++G C +E+S
Sbjct: 805 RCECAPGFAGPDCRIN---INECQSSPCAFGATCVDEINGYRCVCPPGHSGAKC-QEVSG 860
Query: 1454 R-----GERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTD 1508
R G I D + CQ R+ C CGP K EC
Sbjct: 861 RPCITMGSVIPDGAKWDDDCNTCQCLN--GRIAC-----SKVWCGPRPCLLHKGHSECPS 913
Query: 1509 GSSFV 1513
G S +
Sbjct: 914 GQSCI 918
Score = 74.3 bits (181), Expect = 8e-13
Identities = 55/180 (30%), Positives = 73/180 (40%), Gaps = 16/180 (8%)
Query: 1316 ELQDFQKVPMQTGILP-GCEPCHKKVCA-HGTCQPSSQAGFTCECQEGWMGPLCDQRTND 1373
E+ D V M + P G VC HG C+ S FTC+C +G+ G C + ND
Sbjct: 573 EVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENIND 632
Query: 1374 PCLGNKCVH-GTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLG 1432
C N C + GTC+ SY C C +G G C E N C C +G +
Sbjct: 633 -CESNPCRNGGTCID-GVNSYKCICSDGWEGAYC---ETNINDCSQNPCHNGGTCRDLVN 687
Query: 1433 QPYCECSSGYTGDSC-DREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
YC+C +G+ G +C R+ C D G C + C GG G C
Sbjct: 688 DFYCDCKNGWKGKTCHSRDSQC------DEATCNNG-GTCYDEGDAFKCMCPGGWEGTTC 740
Score = 71.6 bits (174), Expect = 5e-12
Identities = 43/118 (36%), Positives = 53/118 (44%), Gaps = 20/118 (16%)
Query: 1341 CAHGTCQPSSQAGFTCECQEGWMGPLCDQ-----RTNDPCLGNKCVHGTCLPINAFSYSC 1395
C HG C Q C C+ W G LCD+ T+ PCL GTC Y C
Sbjct: 271 CVHGICNEPWQ----CLCETNWGGQLCDKDLNYCGTHQPCLNG----GTCSNTGPDKYQC 322
Query: 1396 KCLEGHGGVLCD--EEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREI 1451
C EG+ G C+ E L +PC G C+ + LG CECS G+TG +C I
Sbjct: 323 SCPEGYSGPNCEIAEHACLSDPCH----NRGSCKETSLGFE-CECSPGWTGPTCSTNI 375
Score = 70.9 bits (172), Expect = 9e-12
Identities = 37/113 (32%), Positives = 50/113 (44%), Gaps = 5/113 (4%)
Query: 1336 CHKKVCAHG-TCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYS 1394
C + C +G TC A F C C GW G C+ N CL N C +G +N S++
Sbjct: 709 CDEATCNNGGTCYDEGDA-FKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFT 767
Query: 1395 CKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSC 1447
C C EG G +C + N C C + + G CEC+ G+ G C
Sbjct: 768 CVCKEGWEGPICAQNT---NDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDC 817
Score = 67.0 bits (162), Expect = 1e-10
Identities = 47/163 (28%), Positives = 66/163 (40%), Gaps = 27/163 (16%)
Query: 1336 CHKKVCAHGTCQP---SSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFS 1392
C++ +C G C P S + C CQ GW G CD+ P CVHG C
Sbjct: 229 CNRAICRQG-CSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHP----GCVHGICNE----P 279
Query: 1393 YSCKCLEGHGGVLCDEEED---LFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCD- 1448
+ C C GG LCD++ + PC G C +G + C C GY+G +C+
Sbjct: 280 WQCLCETNWGGQLCDKDLNYCGTHQPC----LNGGTCSNTGPDKYQCSCPEGYSGPNCEI 335
Query: 1449 REISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
E +C + + +C+ T EC G G C
Sbjct: 336 AEHACLSDPCHN-------RGSCKETSLGFECECSPGWTGPTC 371
Score = 58.2 bits (139), Expect = 6e-08
Identities = 40/144 (27%), Positives = 54/144 (37%), Gaps = 26/144 (18%)
Query: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSY 1393
+ C C +G + F C C G+ G LC Q D C N C +G A Y
Sbjct: 489 DECASNPCLNGGHCQNEINRFQCLCPTGFSGNLC-QLDIDYCEPNPCQNGAQCYNRASDY 547
Query: 1394 SCKCLEGHGGVLCDEEED--LFNPCQAIKC-----------------------KHGKCRL 1428
CKC E + G C +D PC+ I HGKC+
Sbjct: 548 FCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKS 607
Query: 1429 SGLGQPYCECSSGYTGDSCDREIS 1452
G+ C+C+ G+TG C I+
Sbjct: 608 QSGGKFTCDCNKGFTGTYCHENIN 631
Score = 53.1 bits (126), Expect = 2e-06
Identities = 30/109 (27%), Positives = 45/109 (41%), Gaps = 9/109 (8%)
Query: 1344 GTCQPSSQA-----GFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCL 1398
G CQ + G+ C C G+ G C+ R D C N C++G + C C
Sbjct: 456 GQCQNDASCRDLVNGYRCICPPGYAGDHCE-RDIDECASNPCLNGGHCQNEINRFQCLCP 514
Query: 1399 EGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSC 1447
G G LC + D C+ C++G + +C+C Y G +C
Sbjct: 515 TGFSGNLCQLDIDY---CEPNPCQNGAQCYNRASDYFCKCPEDYEGKNC 560
>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
Length = 1406
Score = 210 bits (534), Expect = 1e-53
Identities = 146/516 (28%), Positives = 223/516 (43%), Gaps = 67/516 (12%)
Query: 904 KFTCQGPVD---VNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHA 960
++TC P + VN + + C S PC N TC D + Y C C GF G C++
Sbjct: 207 RYTCICPHNYSGVNCELEIDECWSQPCLNGATCQ-DALGAYFCDCAPGFLGDHCELNTDE 265
Query: 961 CISNPCKHGGTCHLKEGEEDGFWCICA-DGFEGENCEVNVDDCEDNDCENNSTCVDGINN 1019
C S PC HGG C E+ + C C GF G +CE + C C NN+TC D ++N
Sbjct: 266 CASQPCLHGGLC---VDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDN 322
Query: 1020 YTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCI--------------------LTPKG 1059
YTC C P YTG CE L+ C + NPCQ + +C+ G
Sbjct: 323 YTCHCWPGYTGAQCEIDLNEC--NSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASG 380
Query: 1060 FKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICP------EGYSGLFCEF 1113
+ C C PG+ G HC+ D ++C N C+NG C + YTC CP Y G C
Sbjct: 381 YVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCS- 439
Query: 1114 SPPMVLPRTSPCDNFDCQNGAQCIVRINEP----ICQCLPGYQGEKCEKLVSVNFINKES 1169
++L C + C N CI + C C GY G CE +++F +
Sbjct: 440 --DILL----GCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEIATTLSF-EGDG 492
Query: 1170 YLQIPSAKVRPQ---TNITLQIATDEDSGILLYKGDKD-HIAVELYRGRVRASYDTGSHP 1225
+L + S V + NI L+ T + +LL++ ++D + +EL G + S +
Sbjct: 493 FLWVKSGSVTTKGSVCNIALRFQTVQPMALLLFRSNRDVFVKLELLSGYIHLSIQVNNQS 552
Query: 1226 ASAIYSVETINDGNFHIVELLALDQ-SLSLSVDGGNPKIITNL-----SKQSTLNFDSPL 1279
++ +DG +H VE++ + +L+L D K I S QS F +
Sbjct: 553 KVLLFISHNTSDGEWHFVEVIFAEAVTLTLIDDSCKEKCIAKAPTPLESDQSICAFQNS- 611
Query: 1280 YVGGMP---GKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILPGCEPC 1336
++GG+P + VA L + SF GC++++ I+ + + + +
Sbjct: 612 FLGGLPVGMTSNGVALLNFYNMPSTPSFVGCLQDIKIDWNHITLENISSGSSLNVKAGCV 671
Query: 1337 HKKVCAHGTCQPSSQA-----GFTCECQEGWMGPLC 1367
K C CQ + + C+C + GP C
Sbjct: 672 RKDWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 197 bits (501), Expect = 6e-50
Identities = 133/463 (28%), Positives = 202/463 (43%), Gaps = 61/463 (13%)
Query: 920 NPCLSNPCKNDGTCNSDPVD-FYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGE 978
+PC SNPC+ TC + P + + C CP G+ G C+ I +C N C+HGG CH
Sbjct: 72 DPCFSNPCQGSATCVNTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICH----- 126
Query: 979 EDGFW--CICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEK 1036
+D + CIC G+ G CE++ D+C + C+N + C DGI+ Y+C C P Y G C+ +
Sbjct: 127 QDPIYPVCICPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLE 186
Query: 1037 LDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVN 1096
+D CA D PC++++ C+ + C C Y G +C+++ D+C C NGA C DA+
Sbjct: 187 VDECASD--PCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALG 244
Query: 1097 GYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCL-PGYQGEK 1155
Y C C G+ G CE + T C + C +G C+ N C C G+ G
Sbjct: 245 AYFCDCAPGFLGDHCELN-------TDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTH 297
Query: 1156 CEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVELYRGRV 1215
CE L +P +P N AT EDS D+ + G
Sbjct: 298 CETL-------------MPLCWSKPCHN----NATCEDS--------VDNYTCHCWPGYT 332
Query: 1216 RASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQSTLNF 1275
A + + ++ N VEL + Q ++ G P + +
Sbjct: 333 GAQCEIDLNECNS-----NPCQSNGECVELSSEKQYGRIT---GLPSSFSYHEASGYVCI 384
Query: 1276 DSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQ----TGILP 1331
P + G+ + +V P QNG + N + + + + IL
Sbjct: 385 CQPGFT-GIHCEEDVNECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSDILL 443
Query: 1332 GCEPCHKKVCAHGTCQP---SSQAGFTCECQEGWMGPLCDQRT 1371
GC H++ +GTC P Q GF+C C G+ G LC+ T
Sbjct: 444 GC--THQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEIAT 484
Score = 180 bits (456), Expect = 1e-44
Identities = 89/238 (37%), Positives = 114/238 (47%), Gaps = 13/238 (5%)
Query: 922 CLSNPCKNDGTCNSDPVDFYRCTCPYGFKG--QDCDVPIHACISNPCKHGGTCHLKEGEE 979
CLSN C+N+ TC D C+C +DCD C SNPC+ TC GE
Sbjct: 34 CLSNSCQNNSTCKDFSKD-NDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCVNTPGER 92
Query: 980 DGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDF 1039
F C C G+ G CE + C N C++ C C+CP Y G CE D
Sbjct: 93 S-FLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCEIDHDE 151
Query: 1040 CAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYT 1099
CA +PCQ+ + C G+ C C PGY G HCD++ D+C + CKN A C + + YT
Sbjct: 152 CAS--SPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEIGRYT 209
Query: 1100 CICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCE 1157
CICP YSG+ CE C + C NGA C + C C PG+ G+ CE
Sbjct: 210 CICPHNYSGVNCEL-------EIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCE 260
Score = 161 bits (408), Expect = 4e-39
Identities = 71/198 (35%), Positives = 101/198 (51%), Gaps = 10/198 (5%)
Query: 920 NPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEE 979
N C SNPC + G C D Y C+CP G+ G+ C++ I C SNPC HG
Sbjct: 1141 NVCNSNPCLHGGNCE-DIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGNC----SDRV 1195
Query: 980 DGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKL-- 1037
+ C C G+ G NCEV++D+C+ + C N +TC+ N Y+CLC +TG+ C +
Sbjct: 1196 AAYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLP 1255
Query: 1038 -DFCAQDLN--PCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDA 1094
C + C + C KC C PG+ GE C+ D D+C + C NG C D
Sbjct: 1256 STVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDL 1315
Query: 1095 VNGYTCICPEGYSGLFCE 1112
+N + C+C ++G CE
Sbjct: 1316 LNKFQCLCDVAFAGERCE 1333
Score = 145 bits (365), Expect = 4e-34
Identities = 72/212 (33%), Positives = 102/212 (48%), Gaps = 16/212 (7%)
Query: 950 KGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEG--ENCEVNVDDCEDNDC 1007
K C+ C+SN C++ TC + D C C+D ++C+ D C N C
Sbjct: 23 KNSFCNKNNTRCLSNSCQNNSTCKDFSKDND---CSCSDTANNLDKDCDNMKDPCFSNPC 79
Query: 1008 ENNSTCVD--GINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCT 1065
+ ++TCV+ G ++ C CPP Y+G +CE + C + N CQH C P C C
Sbjct: 80 QGSATCVNTPGERSFLCKCPPGYSGTICETTIGSCGK--NSCQHGGICHQDPIYPVCICP 137
Query: 1066 PGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPC 1125
GY G C+ID D+C + C+NGA C D ++GY+C C GY G C+ C
Sbjct: 138 AGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDL-------EVDEC 190
Query: 1126 DNFDCQNGAQCIVRINEPICQCLPGYQGEKCE 1157
+ C+N A C+ I C C Y G CE
Sbjct: 191 ASDPCKNEATCLNEIGRYTCICPHNYSGVNCE 222
Score = 128 bits (322), Expect = 4e-29
Identities = 67/188 (35%), Positives = 95/188 (50%), Gaps = 11/188 (5%)
Query: 974 LKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELC 1033
+ + +E+ F I + ++NV C N C + C D ++Y C CP ++G+ C
Sbjct: 1117 INKPQEEQFLKISTNSVVTGCLQLNV--CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHC 1174
Query: 1034 EEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTD 1093
E +D C NPC H + C + C C PGY G +C++D D+CQ ++C NGA C
Sbjct: 1175 ELNIDECFS--NPCIHGN-CSDRVAAYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCIS 1231
Query: 1094 AVNGYTCICPEGYSGLFCEFSPPMVLPRT---SPCDNFDCQNGAQCIVRINEPICQCLPG 1150
NGY+C+C ++G FC S LP T + N C NG C E C C PG
Sbjct: 1232 HTNGYSCLCFGNFTGKFCRQSR---LPSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPG 1288
Query: 1151 YQGEKCEK 1158
+ GE CEK
Sbjct: 1289 FTGEWCEK 1296
Score = 112 bits (281), Expect = 2e-24
Identities = 96/388 (24%), Positives = 157/388 (40%), Gaps = 45/388 (11%)
Query: 1078 DDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCI 1137
+ C+ N C NG C + ++C CP SG CE C C +GA
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE--------EVQWCGFSPCPHGA--- 937
Query: 1138 VRINEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGIL 1197
QC P QG +C N + + + R TNIT T + + I+
Sbjct: 938 --------QCQPVLQGFECIANAVFNGQSGQILFRSNGNITRELTNITFGFRTRDANVII 989
Query: 1198 LY-KGDKDHIAVELYRGRVRASYDTG-SHPASAIYSVETINDGNFHIVEL-----LALDQ 1250
L+ + + + + + + R+ +G S ++ S++++NDG +H V L L+
Sbjct: 990 LHAEKEPEFLNISIQDSRLFFQLQSGNSFYMLSLTSLQSVNDGTWHEVTLSMTDPLSQTS 1049
Query: 1251 SLSLSVDGGNPKIITNLSKQSTLNF---DSPLYVG-----GMPGKSNVASLRQAPGQNGT 1302
+ VD P +T+ +LNF ++ +YVG + G S + G +
Sbjct: 1050 RWQMEVDNETP-FVTSTIATGSLNFLKDNTDIYVGDRAIDNIKGLQGCLSTIEIGGIYLS 1108
Query: 1303 SFHGCIRNLYINSELQDFQKVPMQTGILPGC---EPCHKKVCAHGTCQPSSQAGFTCECQ 1359
F + + + F K+ + ++ GC C+ C HG + + C C
Sbjct: 1109 YFEN-VHGFINKPQEEQFLKISTNS-VVTGCLQLNVCNSNPCLHGGNCEDIYSSYHCSCP 1166
Query: 1360 EGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAI 1419
GW G C+ D C N C+HG C +Y C C G+ GV C+ + D CQ+
Sbjct: 1167 LGWSGKHCELNI-DECFSNPCIHGNCSD-RVAAYHCTCEPGYTGVNCEVDID---NCQSH 1221
Query: 1420 KCKHGKCRLSGLGQPYCECSSGYTGDSC 1447
+C +G +S C C +TG C
Sbjct: 1222 QCANGATCISHTNGYSCLCFGNFTGKFC 1249
Score = 83.6 bits (205), Expect = 1e-15
Identities = 51/158 (32%), Positives = 66/158 (41%), Gaps = 44/158 (27%)
Query: 922 CLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCH-------- 973
C SNPC + G C SD V Y CTC G+ G +C+V I C S+ C +G TC
Sbjct: 1181 CFSNPCIH-GNC-SDRVAAYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSC 1238
Query: 974 LKEGEEDGFWC----------------------------------ICADGFEGENCEVNV 999
L G G +C +C GF GE CE ++
Sbjct: 1239 LCFGNFTGKFCRQSRLPSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDI 1298
Query: 1000 DDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKL 1037
D+C + C N C D +N + CLC + GE CE L
Sbjct: 1299 DECASDPCVNGGLCQDLLNKFQCLCDVAFAGERCEVDL 1336
Score = 67.8 bits (164), Expect = 8e-11
Identities = 53/190 (27%), Positives = 71/190 (37%), Gaps = 14/190 (7%)
Query: 1336 CHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSC 1395
C K C HG C C G+ G C+ +D C + C +G YSC
Sbjct: 114 CGKNSCQHGGICHQDPIYPVCICPAGYAGRFCEI-DHDECASSPCQNGAVCQDGIDGYSC 172
Query: 1396 KCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREISCRG 1455
C+ G+ G CD E D C + CK+ L+ +G+ C C Y+G +C+ EI
Sbjct: 173 FCVPGYQGRHCDLEVD---ECASDPCKNEATCLNEIGRYTCICPHNYSGVNCELEID--- 226
Query: 1456 ERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGSSFVDE 1515
+ Q A CQ +C G G C + S C G VD
Sbjct: 227 ---ECWSQPCLNGATCQDALGAYFCDCAPGFLGDHC---ELNTDECASQPCLHGGLCVDG 280
Query: 1516 VEKVVKCGCT 1525
E C CT
Sbjct: 281 -ENRYSCNCT 289
Score = 67.0 bits (162), Expect = 1e-10
Identities = 66/280 (23%), Positives = 116/280 (41%), Gaps = 29/280 (10%)
Query: 1125 CDNFDCQNGAQCIVRINEPICQCLPGYQGEKC-EKLVSVNFINKES--YLQIPSAKVRPQ 1181
C++ CQ+ +CI C C Y+G C + V+ F +S Y+ +
Sbjct: 676 CESQPCQSRGRCINLWLSYQCDCHRPYEGPNCLREYVAGRFGQDDSTGYVIFTLDESYGD 735
Query: 1182 T-NITLQIATDEDSGILLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNF 1240
T ++++ + T + SG+LL + + + ++ R R + T + P + V +NDGN
Sbjct: 736 TISLSMFVRTLQPSGLLLALENSTYQYIRVWLERGRLAMLTPNSPKLVVKFV--LNDGNV 793
Query: 1241 HIVELLALDQSLSLSVDGGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQN 1300
H++ L + L N I+ + + +Y+GG+P K Q N
Sbjct: 794 HLISLKIKPYKIELYQSSQNLGFIS--ASTWKIEKGDVIYIGGLPDK-------QETELN 844
Query: 1301 GTSFHGCIRNLYINSELQDF--------QKVPMQTGILPGC---EPCHKKVCAHGTCQPS 1349
G F GCI+++ +N++ +F P+ + GC C C +G S
Sbjct: 845 GGFFKGCIQDVRLNNQNLEFFPNPTNNASLNPVLVNVTQGCAGDNSCKSNPCHNGGVCHS 904
Query: 1350 SQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGT-CLPI 1388
F+C C G C++ C + C HG C P+
Sbjct: 905 RWDDFSCSCPALTSGKACEE--VQWCGFSPCPHGAQCQPV 942
Score = 62.8 bits (151), Expect = 2e-09
Identities = 35/116 (30%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVH-GTCLPINAFS 1392
+ C C +G G++C C G+ G CD D C + C + TCL
Sbjct: 150 DECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEV-DECASDPCKNEATCLN-EIGR 207
Query: 1393 YSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCD 1448
Y+C C + GV C+ E D C + C +G LG +C+C+ G+ GD C+
Sbjct: 208 YTCICPHNYSGVNCELEID---ECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCE 260
Score = 59.3 bits (142), Expect = 3e-08
Identities = 37/121 (30%), Positives = 53/121 (43%), Gaps = 7/121 (5%)
Query: 1334 EPCHKKVCAHG-TCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFS 1392
+ C + C +G TCQ + A F C+C G++G C+ T D C C+HG
Sbjct: 226 DECWSQPCLNGATCQDALGAYF-CDCAPGFLGDHCELNT-DECASQPCLHGGLCVDGENR 283
Query: 1393 YSCKCL-EGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREI 1451
YSC C G G C E L C + C + + C C GYTG C+ ++
Sbjct: 284 YSCNCTGSGFTGTHC---ETLMPLCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDL 340
Query: 1452 S 1452
+
Sbjct: 341 N 341
Score = 57.8 bits (138), Expect = 8e-08
Identities = 34/91 (37%), Positives = 46/91 (50%), Gaps = 8/91 (8%)
Query: 910 PVDVNILAKC---NPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPC 966
PV VN+ C N C SNPC N G C+S DF C+CP G+ C+ + C +PC
Sbjct: 876 PVLVNVTQGCAGDNSCKSNPCHNGGVCHSRWDDF-SCSCPALTSGKACE-EVQWCGFSPC 933
Query: 967 KHGGTCHLKEGEEDGFWCICADGFEGENCEV 997
HG C + GF CI F G++ ++
Sbjct: 934 PHGAQC---QPVLQGFECIANAVFNGQSGQI 961
Score = 50.1 bits (118), Expect = 2e-05
Identities = 46/187 (24%), Positives = 67/187 (35%), Gaps = 73/187 (39%)
Query: 1329 ILPGC--EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCV-HGTC 1385
++P C +PCH + TC+ S +TC C G+ G C+ N+ C N C +G C
Sbjct: 301 LMPLCWSKPCHN----NATCEDSVD-NYTCHCWPGYTGAQCEIDLNE-CNSNPCQSNGEC 354
Query: 1386 LPIN-------------------AFSYSCKCLEGHGGVLCDEE--EDLFNPCQ------- 1417
+ ++ A Y C C G G+ C+E+ E NPCQ
Sbjct: 355 VELSSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECSSNPCQNGGTCEN 414
Query: 1418 ---------------------------AIKCKHGKCRLSGLGQPY---------CECSSG 1441
+ C H +C +G P+ C C SG
Sbjct: 415 LPGNYTCHCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSG 474
Query: 1442 YTGDSCD 1448
YTG C+
Sbjct: 475 YTGSLCE 481
Score = 50.1 bits (118), Expect = 2e-05
Identities = 23/78 (29%), Positives = 40/78 (51%), Gaps = 3/78 (3%)
Query: 1000 DDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKG 1059
+ C+ N C N C ++++C CP +G+ CEE + +C +PC H ++C +G
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEE-VQWCG--FSPCPHGAQCQPVLQG 945
Query: 1060 FKCDCTPGYVGEHCDIDF 1077
F+C + G+ I F
Sbjct: 946 FECIANAVFNGQSGQILF 963
Score = 49.3 bits (116), Expect = 3e-05
Identities = 33/111 (29%), Positives = 46/111 (41%), Gaps = 11/111 (9%)
Query: 1343 HGTCQPSSQAGFTCECQE--GWMGPLCDQRTNDPCLGNKCVHGTCLPINA---FSYSCKC 1397
+ TC+ S+ C C + + CD DPC N C G+ +N S+ CKC
Sbjct: 42 NSTCKDFSKDN-DCSCSDTANNLDKDCDNM-KDPCFSNPC-QGSATCVNTPGERSFLCKC 98
Query: 1398 LEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCD 1448
G+ G +C E C C+HG P C C +GY G C+
Sbjct: 99 PPGYSGTIC---ETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCE 146
Score = 44.3 bits (103), Expect = 0.001
Identities = 35/139 (25%), Positives = 54/139 (38%), Gaps = 15/139 (10%)
Query: 1324 PMQTGILPGCEP----CHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQ-RTNDPCLGN 1378
P TG+ CE C CA+G S G++C C + G C Q R GN
Sbjct: 1204 PGYTGV--NCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTVCGN 1261
Query: 1379 K-----CVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQ 1433
+ C +G C C G G C+++ D C + C +G L +
Sbjct: 1262 EKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDID---ECASDPCVNGGLCQDLLNK 1318
Query: 1434 PYCECSSGYTGDSCDREIS 1452
C C + G+ C+ +++
Sbjct: 1319 FQCLCDVAFAGERCEVDLA 1337
Score = 34.3 bits (77), Expect = 0.95
Identities = 25/92 (27%), Positives = 38/92 (41%), Gaps = 9/92 (9%)
Query: 1370 RTNDPCLGNKCVHGTCLPINAFSYSCKCLEGHGGVL--CDEEED--LFNPCQ-AIKCKHG 1424
+ N CL N C + + + C C + + CD +D NPCQ + C +
Sbjct: 29 KNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCVNT 88
Query: 1425 KCRLSGLGQPYCECSSGYTGDSCDREISCRGE 1456
S L C+C GY+G C+ I G+
Sbjct: 89 PGERSFL----CKCPPGYSGTICETTIGSCGK 116
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 209 bits (533), Expect = 1e-53
Identities = 107/342 (31%), Positives = 148/342 (43%), Gaps = 56/342 (16%)
Query: 859 NPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTC-QGPVDVNILA 917
N CDC+ W E C G D T TC +G N
Sbjct: 735 NGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDM----TSGYVCTCREGFSGPNCQT 790
Query: 918 KCNPCLSNPCKNDGTC---------------------------------------NSDPV 938
N C SNPC N GTC S+
Sbjct: 791 NINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDY 850
Query: 939 DFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVN 998
+ + C CP G++GQ C+V I+ C+ +PC+HG +C G G+ C C G+ G NCE +
Sbjct: 851 ESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHG---GYRCHCQAGYSGRNCETD 907
Query: 999 VDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPK 1058
+DDC N C N +C DGIN C C P + G CEE ++ CA D PC++ + C
Sbjct: 908 IDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASD--PCRNGANCTDCVD 965
Query: 1059 GFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMV 1118
+ C C G+ G HC+ + DC ++ C NG C D +N +TC+CP G++G +C+
Sbjct: 966 SYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHD---- 1021
Query: 1119 LPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKLV 1160
+ CD+ C +G C C C GY G C+ LV
Sbjct: 1022 ---VNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLV 1060
Score = 203 bits (516), Expect = 1e-51
Identities = 104/300 (34%), Positives = 142/300 (47%), Gaps = 24/300 (8%)
Query: 863 CDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPVD-VNILAKCNP 921
C C W + + A C D++ F C+ P +L N
Sbjct: 321 CVCVNGWTGEDCSENIDDCASAACFHGATCHDRVA------SFYCECPHGRTGLLCHLND 374
Query: 922 -CLSNPCKNDGTCNSDPVDFYR-CTCPYGFKGQDCDVPIHACI--SNPCKHGGTCHLKEG 977
C+SNPC C+++PV+ CTCP G+ G C + C +NPC+H G C G
Sbjct: 375 ACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLG 434
Query: 978 EEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKL 1037
F C C G+ G CE++V++C N C+N++TC+D I + C+C P Y G CE
Sbjct: 435 S---FECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNT 491
Query: 1038 DFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNG 1097
D CA +PC H+ +C+ F+C+C G+ G C D D+C CKNGA C D N
Sbjct: 492 DECAS--SPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNT 549
Query: 1098 YTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCE 1157
YTC+C EGY+G CE P PC C++G C C PGY G CE
Sbjct: 550 YTCVCTEGYTGTHCEVDIDECDP--DPCHYGSCKDGVATFT------CLCRPGYTGHHCE 601
Score = 196 bits (499), Expect = 1e-49
Identities = 94/243 (38%), Positives = 127/243 (52%), Gaps = 15/243 (6%)
Query: 920 NPCLSNP--CKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEG 977
N C P C++ GTC+++ V YRC C G +C+ P C +PC++GGTC +
Sbjct: 180 NECGQKPGLCRHGGTCHNE-VGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTC--RPT 236
Query: 978 EEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKL 1037
+ C C GF G+NCE N+DDC N+C+N CVDG+N Y C CPPE+TG+ C E +
Sbjct: 237 GDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDV 296
Query: 1038 DFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNG 1097
D C N CQ+ C T G+ C C G+ GE C + DDC C +GA C D V
Sbjct: 297 DECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVAS 356
Query: 1098 YTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVR-IN-EPICQCLPGYQGEK 1155
+ C CP G +GL C + C + C G+ C +N + IC C GY G
Sbjct: 357 FYCECPHGRTGLLCHLN--------DACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPA 408
Query: 1156 CEK 1158
C +
Sbjct: 409 CSQ 411
Score = 192 bits (488), Expect = 2e-48
Identities = 93/242 (38%), Positives = 129/242 (53%), Gaps = 15/242 (6%)
Query: 920 NPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEE 979
N C S PC++ GTC D + Y C C G G +C++ + C S+PC GTC K
Sbjct: 605 NECSSQPCRHGGTCQ-DRDNAYLCFCLKGTTGPNCEINLDDCASSPCD-SGTCLDKI--- 659
Query: 980 DGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDF 1039
DG+ C C G+ G C +N+D+C N C N TC DGIN +TC CP Y C +++
Sbjct: 660 DGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNE 719
Query: 1040 CAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYT 1099
C + NPC H + C + G+KCDC PG+ G +CDI+ ++C+ N C NG C D +GY
Sbjct: 720 C--NSNPCVHGA-CRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYV 776
Query: 1100 CICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKL 1159
C C EG+SG C+ + C + C N CI + C CL Y G CE +
Sbjct: 777 CTCREGFSGPNCQ-------TNINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVV 829
Query: 1160 VS 1161
++
Sbjct: 830 LA 831
Score = 191 bits (486), Expect = 4e-48
Identities = 99/306 (32%), Positives = 138/306 (45%), Gaps = 65/306 (21%)
Query: 906 TCQGPVDVNILAKCNP-------------CLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQ 952
TC+ DV C P C N CKN G C D V+ Y C CP + GQ
Sbjct: 232 TCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGAC-VDGVNTYNCRCPPEWTGQ 290
Query: 953 DCDVPIHAC--ISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENN 1010
C + C + N C++GGTCH G G+ C+C +G+ GE+C N+DDC C +
Sbjct: 291 YCTEDVDECQLMPNACQNGGTCHNTHG---GYNCVCVNGWTGEDCSENIDDCASAACFHG 347
Query: 1011 STCVDGINNY---------------------------------------TCLCPPEYTGE 1031
+TC D + ++ C CP YTG
Sbjct: 348 ATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGP 407
Query: 1032 LCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHC 1091
C + +D C+ NPC+H KCI T F+C C GY G C+ID ++C N C+N A C
Sbjct: 408 ACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATC 467
Query: 1092 TDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGY 1151
D + + CIC GY G+ CE + T C + C + +C+ +INE C+C G+
Sbjct: 468 LDQIGEFQCICMPGYEGVHCEVN-------TDECASSPCLHNGRCLDKINEFQCECPTGF 520
Query: 1152 QGEKCE 1157
G C+
Sbjct: 521 TGHLCQ 526
Score = 191 bits (486), Expect = 4e-48
Identities = 92/243 (37%), Positives = 125/243 (51%), Gaps = 11/243 (4%)
Query: 922 CLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDG 981
C NPC N G+C +D ++ C C GF+G C+ I+ C S+PC++G C D
Sbjct: 911 CRPNPCHNGGSC-TDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANC---TDCVDS 966
Query: 982 FWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCA 1041
+ C C GF G +CE N DC ++ C N TCVDGIN++TCLCPP +TG C+ ++ C
Sbjct: 967 YTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNEC- 1025
Query: 1042 QDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCI 1101
D PC H C ++C C GY G +C C + CKNG C Y C
Sbjct: 1026 -DSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCE 1084
Query: 1102 CPEGYSGLFCEFSPPMVLPRTSPCDNFD----CQNGAQCIVRINEPICQCLPGYQGEKCE 1157
CP G++GL+C+ P + + D CQ+G C+ N C+C GY G CE
Sbjct: 1085 CPSGWTGLYCDV-PSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCE 1143
Query: 1158 KLV 1160
LV
Sbjct: 1144 DLV 1146
Score = 188 bits (478), Expect = 3e-47
Identities = 108/324 (33%), Positives = 150/324 (46%), Gaps = 34/324 (10%)
Query: 857 GANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTC-QGPVDVNI 915
G N C C + + + + E C G D S + TC QG N
Sbjct: 1001 GINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGC----GSYRCTCPQGYTGPNC 1056
Query: 916 LAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHAC----------ISNP 965
+ C S+PCKN G C YRC CP G+ G CDVP +C ++
Sbjct: 1057 QNLVHWCDSSPCKNGGKCWQTHTQ-YRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARL 1115
Query: 966 CKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCP 1025
C+HGG C + C C G+ G CE VD+C + C+N +TC D + Y+C C
Sbjct: 1116 CQHGGLC---VDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCV 1172
Query: 1026 PEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDC----- 1080
Y G C E++D C +PCQ+ C+ P +KC C G G HC+I+ DDC
Sbjct: 1173 AGYHGVNCSEEIDECLS--HPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVD 1230
Query: 1081 ---QDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCI 1137
+ KC N C D V GY+C CP G+ G CE L ++PCD QN C+
Sbjct: 1231 PVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCEGDVNECL--SNPCDARGTQN---CV 1285
Query: 1138 VRINEPICQCLPGYQGEKCEKLVS 1161
R+N+ C+C G+ G +CE +++
Sbjct: 1286 QRVNDFHCECRAGHTGRRCESVIN 1309
Score = 187 bits (475), Expect = 7e-47
Identities = 109/344 (31%), Positives = 152/344 (44%), Gaps = 85/344 (24%)
Query: 887 AGPGEMADKLLLTTPSKKFTC-QGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTC 945
A P E A K + T S + C QG N C+SNPC+ND TC D + ++C C
Sbjct: 420 ANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATC-LDQIGEFQCIC 478
Query: 946 PYGFKGQDCDVPIHACISNPCKHGGTC-----------------HL-------------K 975
G++G C+V C S+PC H G C HL K
Sbjct: 479 MPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCK 538
Query: 976 EGEE--DG---FWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTG 1030
G + DG + C+C +G+ G +CEV++D+C+ + C S C DG+ +TCLC P YTG
Sbjct: 539 NGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGS-CKDGVATFTCLCRPGYTG 597
Query: 1031 ELCEEKLDFCAQDLNPCQH-------------------------------------DSKC 1053
CE ++ C+ PC+H C
Sbjct: 598 HHCETNINECSSQ--PCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTC 655
Query: 1054 ILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEF 1113
+ G++C C PGY G C+I+ D+C N C NG C D +NG+TC CPEGY
Sbjct: 656 LDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGY------- 708
Query: 1114 SPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCE 1157
P L + C++ C +GA C +N C C PG+ G C+
Sbjct: 709 HDPTCLSEVNECNSNPCVHGA-CRDSLNGYKCDCDPGWSGTNCD 751
Score = 182 bits (462), Expect = 2e-45
Identities = 89/252 (35%), Positives = 125/252 (49%), Gaps = 29/252 (11%)
Query: 920 NPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEE 979
N C S+PC+N C +D VD Y CTCP GF G C+ C + C +GGTC
Sbjct: 947 NECASDPCRNGANC-TDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTC------V 999
Query: 980 DG---FWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEK 1036
DG F C+C GF G C+ +V++C+ C + TC DG +Y C CP YTG C+
Sbjct: 1000 DGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNL 1059
Query: 1037 LDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQ----------DNKCK 1086
+ +C D +PC++ KC T ++C+C G+ G +CD+ C+ C+
Sbjct: 1060 VHWC--DSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQ 1117
Query: 1087 NGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQ 1146
+G C DA N + C C GY+G +CE C CQNGA C + C+
Sbjct: 1118 HGGLCVDAGNTHHCRCQAGYTGSYCE-------DLVDECSPSPCQNGATCTDYLGGYSCK 1170
Query: 1147 CLPGYQGEKCEK 1158
C+ GY G C +
Sbjct: 1171 CVAGYHGVNCSE 1182
Score = 177 bits (448), Expect = 9e-44
Identities = 88/249 (35%), Positives = 121/249 (48%), Gaps = 26/249 (10%)
Query: 922 CLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDG 981
C +PC+N TC +D + Y C C G+ G +C I C+S+PC++GGTC +
Sbjct: 1149 CSPSPCQNGATC-TDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCL---DLPNT 1204
Query: 982 FWCICADGFEGENCEVNVDDCE--------DNDCENNSTCVDGINNYTCLCPPEYTGELC 1033
+ C C G +G +CE+NVDDC C NN TCVD + Y+C CPP + GE C
Sbjct: 1205 YKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERC 1264
Query: 1034 EEKLDFCAQDLNPC--QHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHC 1091
E ++ C NPC + C+ F C+C G+ G C+ + C+ CKNG C
Sbjct: 1265 EGDVNECLS--NPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTC 1322
Query: 1092 TDAVN---GYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCL 1148
A N G+ C CP G+ G CE C + C NG CI P C CL
Sbjct: 1323 AVASNTARGFICKCPAGFEGATCEND-------ARTCGSLRCLNGGTCISGPRSPTCLCL 1375
Query: 1149 PGYQGEKCE 1157
+ G +C+
Sbjct: 1376 GPFTGPECQ 1384
Score = 175 bits (444), Expect = 3e-43
Identities = 101/322 (31%), Positives = 139/322 (43%), Gaps = 58/322 (18%)
Query: 885 RCAGPGEMA---DKLLLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCN---SDPV 938
RC+ PGE K ++ C G NPCLS PCKN GTC+ V
Sbjct: 23 RCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGV 82
Query: 939 DFYRCTCPYGFKGQDCDVPI-HACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEV 997
Y C+C GF G C P+ +AC++NPC++GGTC L E + C C G+ G++C+
Sbjct: 83 ADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTE--YKCRCPPGWSGKSCQ- 139
Query: 998 NVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKC---- 1053
D C N C N C+ +Y C CPP + G C + ++ C Q C+H C
Sbjct: 140 QADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEV 199
Query: 1054 --------------------------------ILTPKG---FKCDCTPGYVGEHCDIDFD 1078
P G +C C PG+ G++C+ + D
Sbjct: 200 GSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENID 259
Query: 1079 DCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFC--EFSPPMVLPRTSPCDNFDCQNGAQC 1136
DC N CKNG C D VN Y C CP ++G +C + ++P CQNG C
Sbjct: 260 DCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNA-------CQNGGTC 312
Query: 1137 IVRINEPICQCLPGYQGEKCEK 1158
C C+ G+ GE C +
Sbjct: 313 HNTHGGYNCVCVNGWTGEDCSE 334
Score = 150 bits (378), Expect = 1e-35
Identities = 92/307 (29%), Positives = 137/307 (44%), Gaps = 35/307 (11%)
Query: 859 NPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQ---GPVDVNI 915
N +C C + + + E + C D L ++C+ G VN
Sbjct: 1127 NTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYL------GGYSCKCVAGYHGVNC 1180
Query: 916 LAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACI--------SNPCK 967
+ + CLS+PC+N GTC P + Y+C+CP G +G C++ + C S C
Sbjct: 1181 SEEIDECLSHPCQNGGTCLDLP-NTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCF 1239
Query: 968 HGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNST--CVDGINNYTCLCP 1025
+ GTC + G G+ C C GF GE CE +V++C N C+ T CV +N++ C C
Sbjct: 1240 NNGTCVDQVG---GYSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECR 1296
Query: 1026 PEYTGELCEEKLDFCAQDLNPCQHDSKCIL---TPKGFKCDCTPGYVGEHCDIDFDDCQD 1082
+TG CE ++ C PC++ C + T +GF C C G+ G C+ D C
Sbjct: 1297 AGHTGRRCESVINGCKG--KPCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGS 1354
Query: 1083 NKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPC-DNFDCQNGAQCIVRIN 1141
+C NG C TC+C ++G C+F P +SPC C N C
Sbjct: 1355 LRCLNGGTCISGPRSPTCLCLGPFTGPECQF------PASSPCLGGNPCYNQGTCEPTSE 1408
Query: 1142 EPICQCL 1148
P +CL
Sbjct: 1409 SPFYRCL 1415
Score = 112 bits (281), Expect = 2e-24
Identities = 70/223 (31%), Positives = 96/223 (43%), Gaps = 11/223 (4%)
Query: 857 GANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQ-GPVDVNI 915
G ++C+ N+ + V + P +C G D++ TC G V
Sbjct: 1212 GTQGVHCEINVDDCNPPVDPVSRSP---KCFNNGTCVDQV----GGYSCTCPPGFVGERC 1264
Query: 916 LAKCNPCLSNPCKNDGTCNS-DPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHL 974
N CLSNPC GT N V+ + C C G G+ C+ I+ C PCK+GGTC +
Sbjct: 1265 EGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCAV 1324
Query: 975 KEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCE 1034
GF C C GFEG CE + C C N TC+ G + TCLC +TG C+
Sbjct: 1325 ASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQ 1384
Query: 1035 EKLDFCAQDLNPCQHDSKCILTPKG--FKCDCTPGYVGEHCDI 1075
NPC + C T + ++C C + G C I
Sbjct: 1385 FPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHI 1427
Score = 79.7 bits (195), Expect = 2e-14
Identities = 54/192 (28%), Positives = 84/192 (43%), Gaps = 18/192 (9%)
Query: 1336 CHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVH-GTCLPINAFSYS 1394
C C +G +G+ C C+EG+ GP C N+ C N C++ GTC+ + Y
Sbjct: 757 CESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINE-CASNPCLNQGTCID-DVAGYK 814
Query: 1395 CKCLEGHGGVLCDEEEDLFNPCQAIKCKH-GKCRLSGLGQPY-CECSSGYTGDSCDREIS 1452
C CL + G C E + PC C++ G+CR S + + C C +G+ G +C+ +I+
Sbjct: 815 CNCLLPYTGATC---EVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDIN 871
Query: 1453 CRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGSSF 1512
+ A+CQ T R C+ G +G C + R C +G S
Sbjct: 872 ------ECVLSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPN---PCHNGGSC 922
Query: 1513 VDEVEKVVKCGC 1524
D + C C
Sbjct: 923 TDGINTAF-CDC 933
Score = 77.4 bits (189), Expect = 1e-13
Identities = 44/161 (27%), Positives = 66/161 (40%), Gaps = 17/161 (10%)
Query: 1007 CENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPK----GFKC 1062
C N C C+C + G C++ + PC++ C + + + C
Sbjct: 31 CLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLS---TPCKNAGTCHVVDRRGVADYAC 87
Query: 1063 DCTPGYVGEHCDIDFDD-CQDNKCKNGAHCTD-AVNGYTCICPEGYSGLFCEFSPPMVLP 1120
C G+ G C D+ C N C+NG C + Y C CP G+SG C+
Sbjct: 88 SCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQ-------- 139
Query: 1121 RTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKLVS 1161
+ PC + C NG QC+ IC C P + G C + V+
Sbjct: 140 QADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVN 180
Score = 73.9 bits (180), Expect = 1e-12
Identities = 40/122 (32%), Positives = 55/122 (45%), Gaps = 10/122 (8%)
Query: 1331 PGCE----PCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCL 1386
P CE C C GTC G+ C C+ G+ G +C+ D C GN C +G
Sbjct: 636 PNCEINLDDCASSPCDSGTCLDKID-GYECACEPGYTGSMCNINI-DECAGNPCHNGGTC 693
Query: 1387 PINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDS 1446
++C+C EG+ C E N C + C HG CR L C+C G++G +
Sbjct: 694 EDGINGFTCRCPEGYHDPTCLSE---VNECNSNPCVHGACR-DSLNGYKCDCDPGWSGTN 749
Query: 1447 CD 1448
CD
Sbjct: 750 CD 751
Score = 72.0 bits (175), Expect = 4e-12
Identities = 49/179 (27%), Positives = 77/179 (43%), Gaps = 11/179 (6%)
Query: 1280 YVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILPGCE----P 1335
Y+ P + + RQ + G C ++E+ ++ V T P CE P
Sbjct: 162 YICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVP 221
Query: 1336 CHKKVCAHG-TCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYS 1394
C C +G TC+P+ C C G+ G C++ +D C GN C +G +Y+
Sbjct: 222 CSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDD-CPGNNCKNGGACVDGVNTYN 280
Query: 1395 CKCLEGHGGVLCDEEEDLFNPCQAI--KCKHGKCRLSGLGQPYCECSSGYTGDSCDREI 1451
C+C G C E+ D CQ + C++G + G C C +G+TG+ C I
Sbjct: 281 CRCPPEWTGQYCTEDVD---ECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENI 336
Score = 70.9 bits (172), Expect = 9e-12
Identities = 40/118 (33%), Positives = 51/118 (43%), Gaps = 10/118 (8%)
Query: 1335 PCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYS 1394
PCH GTC+ GFTC C EG+ P C N+ C N CVHG C + Y
Sbjct: 686 PCHNG----GTCEDGIN-GFTCRCPEGYHDPTCLSEVNE-CNSNPCVHGACRD-SLNGYK 738
Query: 1395 CKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREIS 1452
C C G G CD N C++ C +G C C G++G +C I+
Sbjct: 739 CDCDPGWSGTNCDINN---NECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNIN 793
Score = 70.9 bits (172), Expect = 9e-12
Identities = 47/181 (25%), Positives = 72/181 (39%), Gaps = 22/181 (12%)
Query: 1335 PCHKKVCAHG-TCQPSSQ-AGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFS 1392
PC C +G C+ S F+C C GW G C+ N+ C+ + C HG
Sbjct: 832 PCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINE-CVLSPCRHGASCQNTHGG 890
Query: 1393 YSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREIS 1452
Y C C G+ G C+ + D C+ C +G G+ +C+C G+ G C+ +I+
Sbjct: 891 YRCHCQAGYSGRNCETDID---DCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDIN 947
Query: 1453 -CRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGSS 1511
C + R+ A C C G +G C + +CT+ S
Sbjct: 948 ECASDPCRN-------GANCTDCVDSYTCTCPAGFSGIHC--------ENNTPDCTESSC 992
Query: 1512 F 1512
F
Sbjct: 993 F 993
Score = 70.5 bits (171), Expect = 1e-11
Identities = 57/208 (27%), Positives = 81/208 (38%), Gaps = 21/208 (10%)
Query: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSY 1393
+ C C HG A F CEC G G LC ND C+ N C G+ N +
Sbjct: 337 DDCASAACFHGATCHDRVASFYCECPHGRTGLLC--HLNDACISNPCNEGSNCDTNPVNG 394
Query: 1394 S--CKCLEGHGGVLCDEEEDLFNPCQAIKCKH-GKCRLSGLGQPYCECSSGYTGDSCDRE 1450
C C G+ G C ++ D + A C+H GKC ++ LG C+C GYTG C+ +
Sbjct: 395 KAICTCPSGYTGPACSQDVDECS-LGANPCEHAGKC-INTLGSFECQCLQGYTGPRCEID 452
Query: 1451 IS------CRGERIRDYYQKQQGYAACQTTKKVSRLECR---GGCAGGQCCGPLRSKRRK 1501
++ C+ + Q G C + C CA C R +
Sbjct: 453 VNECVSNPCQNDAT---CLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKI 509
Query: 1502 YSFECTDGSSFVDEV--EKVVKCGCTRC 1527
F+C + F + V +C T C
Sbjct: 510 NEFQCECPTGFTGHLCQYDVDECASTPC 537
Score = 69.3 bits (168), Expect = 3e-11
Identities = 50/172 (29%), Positives = 67/172 (38%), Gaps = 22/172 (12%)
Query: 1330 LPGCEPCHKKV----CAHGTCQPSSQA-----GFTCECQEGWMGPLCDQRTNDPCLGNKC 1380
+PG E H +V CA C + + F CEC G+ G LC Q D C C
Sbjct: 479 MPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLC-QYDVDECASTPC 537
Query: 1381 VHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSS 1440
+G +Y+C C EG+ G C+ + D C C +G C+ G+ C C
Sbjct: 538 KNGAKCLDGPNTYTCVCTEGYTGTHCEVDID---ECDPDPCHYGSCK-DGVATFTCLCRP 593
Query: 1441 GYTGDSCDREIS-CRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
GYTG C+ I+ C + R CQ C G G C
Sbjct: 594 GYTGHHCETNINECSSQPCRH-------GGTCQDRDNAYLCFCLKGTTGPNC 638
Score = 68.9 bits (167), Expect = 3e-11
Identities = 35/110 (31%), Positives = 53/110 (48%), Gaps = 8/110 (7%)
Query: 1344 GTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGHGG 1403
GTC ++ G+ C C GW G C + +D C C HG S+ C+C G G
Sbjct: 310 GTCH-NTHGGYNCVCVNGWTGEDCSENIDD-CASAACFHGATCHDRVASFYCECPHGRTG 367
Query: 1404 VLCD-EEEDLFNPCQAIKCKHGKCRLSGL-GQPYCECSSGYTGDSCDREI 1451
+LC + + NPC + C + + G+ C C SGYTG +C +++
Sbjct: 368 LLCHLNDACISNPCN----EGSNCDTNPVNGKAICTCPSGYTGPACSQDV 413
Score = 67.4 bits (163), Expect = 1e-10
Identities = 54/169 (31%), Positives = 69/169 (40%), Gaps = 23/169 (13%)
Query: 1331 PGCEPCHKKVCAHGTCQPSS----QAG-FTCECQEGWMGPLCDQRTNDPCLGNKCVH-GT 1384
P CE C CQ + Q G F C C G+ G C+ T D C + C+H G
Sbjct: 447 PRCE-IDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNT-DECASSPCLHNGR 504
Query: 1385 CLP-INAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYT 1443
CL IN F C+C G G LC + D C + CK+G L G C C+ GYT
Sbjct: 505 CLDKINEFQ--CECPTGFTGHLCQYDVD---ECASTPCKNGAKCLDGPNTYTCVCTEGYT 559
Query: 1444 GDSCDREI-SCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
G C+ +I C + Y +C+ CR G G C
Sbjct: 560 GTHCEVDIDECDPDPCH--------YGSCKDGVATFTCLCRPGYTGHHC 600
Score = 67.4 bits (163), Expect = 1e-10
Identities = 52/209 (24%), Positives = 80/209 (38%), Gaps = 28/209 (13%)
Query: 1336 CHKKVCAHG-TCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYS 1394
C + C HG TCQ A + C C +G GP C+ +D C + C GTCL Y
Sbjct: 607 CSSQPCRHGGTCQDRDNA-YLCFCLKGTTGPNCEINLDD-CASSPCDSGTCLD-KIDGYE 663
Query: 1395 CKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREISCR 1454
C C G+ G +C+ D C C +G G+ C C GY +C E++
Sbjct: 664 CACEPGYTGSMCNINID---ECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVN-- 718
Query: 1455 GERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC------C--------GPLRSKRR 1500
+ + AC+ + + +C G +G C C G +
Sbjct: 719 -----ECNSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTS 773
Query: 1501 KYSFECTDGSSFVDEVEKVVKCGCTRCVS 1529
Y C +G S + + +C C++
Sbjct: 774 GYVCTCREGFSGPNCQTNINECASNPCLN 802
Score = 67.0 bits (162), Expect = 1e-10
Identities = 44/160 (27%), Positives = 58/160 (36%), Gaps = 12/160 (7%)
Query: 1336 CHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSC 1395
C C +G +TC C G+ G C+ T D C + C +G S++C
Sbjct: 949 CASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPD-CTESSCFNGGTCVDGINSFTC 1007
Query: 1396 KCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREIS-CR 1454
C G G C + N C + C HG G G C C GYTG +C + C
Sbjct: 1008 LCPPGFTGSYCQHD---VNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCD 1064
Query: 1455 GERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGP 1494
++ C T R EC G G C P
Sbjct: 1065 SSPCKN-------GGKCWQTHTQYRCECPSGWTGLYCDVP 1097
Score = 66.2 bits (160), Expect = 2e-10
Identities = 39/135 (28%), Positives = 61/135 (45%), Gaps = 12/135 (8%)
Query: 1331 PGCE---PCHKKVCAH-GTCQPSSQAG---FTCECQEGWMGPLCDQRTNDPCLGNKCVH- 1382
P C+ PC C + GTC + G + C C G+ GPLC ++ CL N C +
Sbjct: 55 PRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNG 114
Query: 1383 GTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGY 1442
GTC + Y C+C G G C + + PC + C +G L C C +
Sbjct: 115 GTCDLLTLTEYKCRCPPGWSGKSCQQAD----PCASNPCANGGQCLPFEASYICHCPPSF 170
Query: 1443 TGDSCDREISCRGER 1457
G +C ++++ G++
Sbjct: 171 HGPTCRQDVNECGQK 185
Score = 62.8 bits (151), Expect = 2e-09
Identities = 51/206 (24%), Positives = 73/206 (35%), Gaps = 31/206 (15%)
Query: 1331 PGCEP----CHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCD---------QRTNDPCLG 1377
P C+ C C +G + + CEC GW G CD + +
Sbjct: 1054 PNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVA 1113
Query: 1378 NKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCE 1437
C HG ++ C+C G+ G C EDL + C C++G LG C+
Sbjct: 1114 RLCQHGGLCVDAGNTHHCRCQAGYTGSYC---EDLVDECSPSPCQNGATCTDYLGGYSCK 1170
Query: 1438 CSSGYTGDSCDREI-SCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC----- 1491
C +GY G +C EI C Q C + C G G C
Sbjct: 1171 CVAGYHGVNCSEEIDECLSHPC-------QNGGTCLDLPNTYKCSCPRGTQGVHCEINVD 1223
Query: 1492 -CGPLRSKRRKYSFECTDGSSFVDEV 1516
C P + S +C + + VD+V
Sbjct: 1224 DCNPPVDPVSR-SPKCFNNGTCVDQV 1248
Score = 56.6 bits (135), Expect = 2e-07
Identities = 32/97 (32%), Positives = 45/97 (46%), Gaps = 7/97 (7%)
Query: 1354 FTCECQEGWMGPLCDQRTNDPCLGNKCVHG-TCLPIN--AFSYSCKCLEGHGGVLCDEEE 1410
F CEC+ G G C+ N C G C +G TC + A + CKC G G C+ +
Sbjct: 1291 FHCECRAGHTGRRCESVING-CKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDA 1349
Query: 1411 DLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSC 1447
C +++C +G +SG P C C +TG C
Sbjct: 1350 ---RTCGSLRCLNGGTCISGPRSPTCLCLGPFTGPEC 1383
Score = 56.2 bits (134), Expect = 2e-07
Identities = 55/216 (25%), Positives = 81/216 (37%), Gaps = 59/216 (27%)
Query: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHG-TCLPINAFS 1392
+ C C +G G++C+C G+ G C + D CL + C +G TCL + +
Sbjct: 1147 DECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEI-DECLSHPCQNGGTCLDLPN-T 1204
Query: 1393 YSCKCLEGHGGVLCDEEEDLFNP-----CQAIKC-KHGKC------------------RL 1428
Y C C G GV C+ D NP ++ KC +G C R
Sbjct: 1205 YKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERC 1264
Query: 1429 SG-----LGQP----------------YCECSSGYTGDSCDREIS-CRGERIRDYYQKQQ 1466
G L P +CEC +G+TG C+ I+ C+G+ ++
Sbjct: 1265 EGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKN----GG 1320
Query: 1467 GYAACQTTKKVSRLECRGGCAGGQC------CGPLR 1496
A T + +C G G C CG LR
Sbjct: 1321 TCAVASNTARGFICKCPAGFEGATCENDARTCGSLR 1356
Score = 40.8 bits (94), Expect = 0.010
Identities = 26/74 (35%), Positives = 32/74 (43%), Gaps = 3/74 (4%)
Query: 1336 CHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCL-GNKCVH-GTCLPINAFS- 1392
C C +G S TC C + GP C + PCL GN C + GTC P +
Sbjct: 1352 CGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPTSESPF 1411
Query: 1393 YSCKCLEGHGGVLC 1406
Y C C G+LC
Sbjct: 1412 YRCLCPAKFNGLLC 1425
>gi|112420992 crumbs homolog 2 [Homo sapiens]
Length = 1285
Score = 206 bits (523), Expect = 2e-52
Identities = 153/527 (29%), Positives = 226/527 (42%), Gaps = 93/527 (17%)
Query: 906 TCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNP 965
TC+ VD C S PC + G+C D V +RC C G+ G C + + C S P
Sbjct: 142 TCEMEVD--------ECASAPCLHGGSC-LDGVGSFRCVCAPGYGGTRCQLDLDECQSQP 192
Query: 966 CKHGGTCHLKEGEEDGFWCICAD-GFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLC 1024
C HGGTCH +GF C CA G+EG +CE V +C CE+N++C++G+ ++ CLC
Sbjct: 193 CAHGGTCH---DLVNGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSFRCLC 249
Query: 1025 PPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPK---------------------GFKCD 1063
P Y+GELCE D CA +PCQH +C+ GF C
Sbjct: 250 WPGYSGELCEVDEDECAS--SPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCH 307
Query: 1064 CTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCE------FSPPM 1117
C PG+ G C ++ D+C C NG HC D NG+ C CP+GY+G CE S P
Sbjct: 308 CPPGFEGADCGVEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPC 367
Query: 1118 V---------------LPRT----------SPCDNFDCQNGAQCIV----RINEPICQCL 1148
+ P T + C C A CI ++ +C C
Sbjct: 368 LHGGTCSDTVAGYICRCPETWGGRDCSVQLTGCQGHTCPLAATCIPIFESGVHSYVCHCP 427
Query: 1149 PGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGD-KDHIA 1207
PG G C + + + + S +Q S + L+ T +G L + D K+ +
Sbjct: 428 PGTHGPFCGQNTTFS-VMAGSPIQA-SVPAGGPLGLALRFRTTLPAGTLATRNDTKESLE 485
Query: 1208 VELYRGRVRASYDTGSHPASAIYSVE-TINDGNFHIVELLALDQSLSLSV-DGGNPKIIT 1265
+ L ++A+ + S + + +NDG++H VE++ +L L + G P +
Sbjct: 486 LALVAATLQATLWSYSTTVLVLRLPDLALNDGHWHQVEVVLHLATLELRLWHEGCPARLC 545
Query: 1266 NLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPM 1325
S L S +P + A L A +F GC++++ ++ L +P
Sbjct: 546 VASGPVALA--STASATPLPAGISSAQLGDA------TFAGCLQDVRVDGHLL----LPE 593
Query: 1326 QTG--ILPGCE---PCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLC 1367
G +L GCE C C HG F C+C GP C
Sbjct: 594 DLGENVLLGCERREQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTC 640
Score = 171 bits (432), Expect = 6e-42
Identities = 83/237 (35%), Positives = 111/237 (46%), Gaps = 20/237 (8%)
Query: 922 CLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDG 981
C S+PC C + Y C P +G C + PC HG C + + G
Sbjct: 42 CASDPCAPGTECQATESGGYTCG-PMEPRG---------CATQPCHHGALCVPQGPDPTG 91
Query: 982 FWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCA 1041
F C C GF+G CE+++D+C C + +TC + + Y C CP Y G CE ++D CA
Sbjct: 92 FRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECA 151
Query: 1042 QDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCI 1101
PC H C+ F+C C PGY G C +D D+CQ C +G C D VNG+ C
Sbjct: 152 S--APCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCD 209
Query: 1102 CP-EGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCE 1157
C GY G CE C + C++ A C+ + C C PGY GE CE
Sbjct: 210 CAGTGYEGTHCE-------REVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCE 259
Score = 167 bits (423), Expect = 7e-41
Identities = 84/259 (32%), Positives = 120/259 (46%), Gaps = 35/259 (13%)
Query: 922 CLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDG 981
C S PC + TC + D Y C CP G+ G C++ + C S PC HGG+C G
Sbjct: 112 CASRPCHHGATCRN-LADRYECHCPLGYAGVTCEMEVDECASAPCLHGGSCLDGVGS--- 167
Query: 982 FWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPE-YTGELCEEKLDFC 1040
F C+CA G+ G C++++D+C+ C + TC D +N + C C Y G CE ++ C
Sbjct: 168 FRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLEC 227
Query: 1041 AQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVN---- 1096
A PC+H++ C+ F+C C PGY GE C++D D+C + C++G C +
Sbjct: 228 ASA--PCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALY 285
Query: 1097 -----------------GYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVR 1139
G+ C CP G+ G C C + C NG C
Sbjct: 286 GGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVE-------VDECASRPCLNGGHCQDL 338
Query: 1140 INEPICQCLPGYQGEKCEK 1158
N C C GY G CE+
Sbjct: 339 PNGFQCHCPDGYAGPTCEE 357
Score = 99.4 bits (246), Expect = 2e-20
Identities = 53/165 (32%), Positives = 65/165 (39%), Gaps = 4/165 (2%)
Query: 961 CISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNY 1020
C +PC H G C D F C C G+EG CE +VD C C +
Sbjct: 1060 CAPSPCLHDGACR---DLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRF 1116
Query: 1021 TCLCPPEYTGELCEEKLDFCAQDLN-PCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDD 1079
C CPP + G C + LN C S C C C G G+ C +
Sbjct: 1117 ECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLP 1176
Query: 1080 CQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSP 1124
C+ N C NG C A CIC +SG FCE + + LP P
Sbjct: 1177 CEANPCLNGGTCRAAGGVSECICNARFSGQFCEVAKGLPLPLPFP 1221
Score = 76.6 bits (187), Expect = 2e-13
Identities = 47/160 (29%), Positives = 66/160 (41%), Gaps = 14/160 (8%)
Query: 1002 CEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKG-F 1060
C + C ++ C D + + C C P + G CE +D C PC +C P G F
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSA--PCAR-GRCHTHPDGRF 1116
Query: 1061 KCDCTPGYVGEHC--DIDFDDCQDN-KCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPM 1117
+C C PG+ G C + +C N C +G+ C C C EG +G C+
Sbjct: 1117 ECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVP--- 1173
Query: 1118 VLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCE 1157
T PC+ C NG C C C + G+ CE
Sbjct: 1174 ----TLPCEANPCLNGGTCRAAGGVSECICNARFSGQFCE 1209
Score = 75.9 bits (185), Expect = 3e-13
Identities = 42/119 (35%), Positives = 52/119 (43%), Gaps = 7/119 (5%)
Query: 1336 CHKKVCAHGT-CQPSSQ--AGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFS 1392
C + C HG C P GF C C G+ GP C+ D C C HG A
Sbjct: 71 CATQPCHHGALCVPQGPDPTGFRCYCVPGFQGPRCELDI-DECASRPCHHGATCRNLADR 129
Query: 1393 YSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREI 1451
Y C C G+ GV C+ E D C + C HG L G+G C C+ GY G C ++
Sbjct: 130 YECHCPLGYAGVTCEMEVD---ECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDL 185
Score = 67.0 bits (162), Expect = 1e-10
Identities = 38/126 (30%), Positives = 54/126 (42%), Gaps = 9/126 (7%)
Query: 1331 PGCE----PCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCL 1386
P CE C + C HG + + C C G+ G C+ D C C+HG
Sbjct: 103 PRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEV-DECASAPCLHGGSC 161
Query: 1387 PINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECS-SGYTGD 1445
S+ C C G+GG C + D CQ+ C HG + C+C+ +GY G
Sbjct: 162 LDGVGSFRCVCAPGYGGTRCQLDLD---ECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGT 218
Query: 1446 SCDREI 1451
C+RE+
Sbjct: 219 HCEREV 224
Score = 65.9 bits (159), Expect = 3e-10
Identities = 40/125 (32%), Positives = 56/125 (44%), Gaps = 11/125 (8%)
Query: 1331 PGCE----PCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLC--DQRTNDPCLGNKCVHGT 1384
P CE PCH CA G C F C C G+ GP C + + L C+ G+
Sbjct: 1089 PRCEAHVDPCHSAPCARGRCHTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGS 1148
Query: 1385 CLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKH-GKCRLSGLGQPYCECSSGYT 1443
+ + +C CLEG G C PC+A C + G CR +G G C C++ ++
Sbjct: 1149 PCEGGSPAANCSCLEGLAGQRCQVPT---LPCEANPCLNGGTCRAAG-GVSECICNARFS 1204
Query: 1444 GDSCD 1448
G C+
Sbjct: 1205 GQFCE 1209
Score = 60.5 bits (145), Expect = 1e-08
Identities = 35/116 (30%), Positives = 45/116 (38%), Gaps = 5/116 (4%)
Query: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSY 1393
+ C C HG F C C G+ G C Q D C C HG +
Sbjct: 148 DECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRC-QLDLDECQSQPCAHGGTCHDLVNGF 206
Query: 1394 SCKCL-EGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCD 1448
C C G+ G C+ E C + C+H L GLG C C GY+G+ C+
Sbjct: 207 RCDCAGTGYEGTHCERE---VLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCE 259
Score = 59.3 bits (142), Expect = 3e-08
Identities = 34/118 (28%), Positives = 47/118 (39%), Gaps = 8/118 (6%)
Query: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSY 1393
+ C + C +G GF C C +G+ GP C++ D CL + C+HG Y
Sbjct: 322 DECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDV-DECLSDPCLHGGTCSDTVAGY 380
Query: 1394 SCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRL----SGLGQPYCECSSGYTGDSC 1447
C+C E GG C + CQ C + SG+ C C G G C
Sbjct: 381 ICRCPETWGGRDCSVQ---LTGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHGPFC 435
Score = 58.5 bits (140), Expect = 5e-08
Identities = 36/104 (34%), Positives = 46/104 (44%), Gaps = 8/104 (7%)
Query: 899 TTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTC-NSDPVD----FYRCTCPYGFKGQD 953
T P +F C+ P P S C + TC + P + C+C G GQ
Sbjct: 1110 THPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQR 1169
Query: 954 CDVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEV 997
C VP C +NPC +GGTC G + CIC F G+ CEV
Sbjct: 1170 CQVPTLPCEANPCLNGGTCRAAGGVSE---CICNARFSGQFCEV 1210
Score = 58.2 bits (139), Expect = 6e-08
Identities = 35/117 (29%), Positives = 40/117 (34%), Gaps = 3/117 (2%)
Query: 1332 GCEPCHKKVCAH-GTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINA 1390
G C C H G C+ A F C C GW GP C+ DPC C G C
Sbjct: 1056 GAPVCAPSPCLHDGACRDLFDA-FACACGPGWEGPRCEAHV-DPCHSAPCARGRCHTHPD 1113
Query: 1391 FSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSC 1447
+ C+C G GG C + C G G C C G G C
Sbjct: 1114 GRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRC 1170
Score = 54.3 bits (129), Expect = 9e-07
Identities = 46/180 (25%), Positives = 63/180 (35%), Gaps = 32/180 (17%)
Query: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQ-EGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFS 1392
+ C + CAHG GF C+C G+ G C++ + C C H S
Sbjct: 186 DECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLE-CASAPCEHNASCLEGLGS 244
Query: 1393 YSCKCLEGHGGVLCDEEEDLFNPCQAIKCKH-GKC------RLSGLGQP----------- 1434
+ C C G+ G LC+ +ED C + C+H G+C L G Q
Sbjct: 245 FRCLCWPGYSGELCEVDED---ECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHA 301
Query: 1435 ---YCECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
C C G+ G C E+ R CQ + C G AG C
Sbjct: 302 AGFLCHCPPGFEGADCGVEVDECASR------PCLNGGHCQDLPNGFQCHCPDGYAGPTC 355
Score = 52.4 bits (124), Expect = 3e-06
Identities = 29/105 (27%), Positives = 44/105 (41%), Gaps = 5/105 (4%)
Query: 1352 AGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEED 1411
AGF C C G+ G C D C C++G + C C +G+ G C+E+ D
Sbjct: 302 AGFLCHCPPGFEGADCGVEV-DECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVD 360
Query: 1412 LFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREIS-CRG 1455
C + C HG + C C + G C +++ C+G
Sbjct: 361 ---ECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQLTGCQG 402
Score = 49.7 bits (117), Expect = 2e-05
Identities = 57/199 (28%), Positives = 79/199 (39%), Gaps = 32/199 (16%)
Query: 804 LTLILSYNRLRC---------IPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHL 854
LT+ LS R+R +P R DGL+ L +LS + + DL H+
Sbjct: 696 LTVFLSEGRIRAEVPGSPAVVLPGRWDDGLRHLVMLSFGPDQLQ--------DLG--QHV 745
Query: 855 AIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPVDVN 914
+G L D + W + + ++ + C P L L S+ G N
Sbjct: 746 HVGGRLLAAD-SQPWGGPF-RGCLQDLRLDGCHLP---FFPLPLDNSSQPSELGGRQSWN 800
Query: 915 ILAKC---NPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGT 971
+ A C + C +PC N GTC DF+ CTCP F G C + C PC T
Sbjct: 801 LTAGCVSEDMCSPDPCFNGGTCLVTWNDFH-CTCPANFTGPTCAQQLW-CPGQPCLPPAT 858
Query: 972 CHLKEGEEDGFWCICADGF 990
C E DGF C+ F
Sbjct: 859 C---EEVPDGFVCVAEATF 874
Score = 47.8 bits (112), Expect = 8e-05
Identities = 23/66 (34%), Positives = 33/66 (50%), Gaps = 3/66 (4%)
Query: 997 VNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILT 1056
V+ D C + C N TC+ N++ C CP +TG C ++L +C PC + C
Sbjct: 806 VSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPG--QPCLPPATCEEV 862
Query: 1057 PKGFKC 1062
P GF C
Sbjct: 863 PDGFVC 868
Score = 47.0 bits (110), Expect = 1e-04
Identities = 36/137 (26%), Positives = 47/137 (34%), Gaps = 25/137 (18%)
Query: 1336 CHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHG-TCLPIN----- 1389
C C H F C C G+ G LC+ D C + C HG CL +
Sbjct: 227 CASAPCEHNASCLEGLGSFRCLCWPGYSGELCEV-DEDECASSPCQHGGRCLQRSDPALY 285
Query: 1390 ---------AFSYS------CKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQP 1434
AFS+ C C G G C E D C + C +G
Sbjct: 286 GGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVD---ECASRPCLNGGHCQDLPNGF 342
Query: 1435 YCECSSGYTGDSCDREI 1451
C C GY G +C+ ++
Sbjct: 343 QCHCPDGYAGPTCEEDV 359
Score = 38.1 bits (87), Expect = 0.066
Identities = 18/64 (28%), Positives = 27/64 (42%), Gaps = 3/64 (4%)
Query: 1038 DFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNG 1097
D C+ D PC + C++T F C C + G C C C A C + +G
Sbjct: 809 DMCSPD--PCFNGGTCLVTWNDFHCTCPANFTGPTCAQQLW-CPGQPCLPPATCEEVPDG 865
Query: 1098 YTCI 1101
+ C+
Sbjct: 866 FVCV 869
Score = 33.9 bits (76), Expect = 1.2
Identities = 24/86 (27%), Positives = 35/86 (40%), Gaps = 8/86 (9%)
Query: 1028 YTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFK--CDCTPGYVGEHCDIDFDDCQDNKC 1085
+ G L + +LD C P D+ + G + + T G V E D C + C
Sbjct: 763 FRGCLQDLRLDGCHLPFFPLPLDNSSQPSELGGRQSWNLTAGCVSE------DMCSPDPC 816
Query: 1086 KNGAHCTDAVNGYTCICPEGYSGLFC 1111
NG C N + C CP ++G C
Sbjct: 817 FNGGTCLVTWNDFHCTCPANFTGPTC 842
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 204 bits (520), Expect = 4e-52
Identities = 100/255 (39%), Positives = 133/255 (52%), Gaps = 20/255 (7%)
Query: 906 TCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNP 965
+C+ VD +C + PC++ GTC + P F RC CP G+ G C+ P C +P
Sbjct: 154 SCRSDVD-----ECR--VGEPCRHGGTCLNTPGSF-RCQCPAGYTGPLCENPAVPCAPSP 205
Query: 966 CKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCP 1025
C++GGTC ++ + + C C GFEG+NCEVNVDDC + C N TCVDG+N Y C CP
Sbjct: 206 CRNGGTC--RQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCP 263
Query: 1026 PEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKC 1085
PE+TG+ C E +D C N C + C T G C C G+ GE C + DDC C
Sbjct: 264 PEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVC 323
Query: 1086 KNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVR-IN-EP 1143
+GA C D V + C CP G +GL C C + C A C +N
Sbjct: 324 FHGATCHDRVASFYCACPMGKTGLLCHLD--------DACVSNPCHEDAICDTNPVNGRA 375
Query: 1144 ICQCLPGYQGEKCEK 1158
IC C PG+ G C++
Sbjct: 376 ICTCPPGFTGGACDQ 390
Score = 192 bits (488), Expect = 2e-48
Identities = 91/242 (37%), Positives = 123/242 (50%), Gaps = 16/242 (6%)
Query: 922 CLSNPCKNDGTCNSDPVDFYR-CTCPYGFKGQDCDVPIHACI--SNPCKHGGTCHLKEGE 978
C+SNPC D C+++PV+ CTCP GF G CD + C +NPC+H G C +G
Sbjct: 355 CVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGS 414
Query: 979 EDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLD 1038
F C C G+ G CE +V++C C N +TC+D I +TC+C +TG CE +D
Sbjct: 415 ---FLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDID 471
Query: 1039 FCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGY 1098
C +PC + C GF C C G+ G C +D D+C C+NGA C D +GY
Sbjct: 472 ECQS--SPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGY 529
Query: 1099 TCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEK 1158
C C EG+ G C+ C C +G +C+ I C C PGY G +CE
Sbjct: 530 ECRCAEGFEGTLCD-------RNVDDCSPDPCHHG-RCVDGIASFSCACAPGYTGTRCES 581
Query: 1159 LV 1160
V
Sbjct: 582 QV 583
Score = 189 bits (479), Expect = 2e-47
Identities = 89/237 (37%), Positives = 123/237 (51%), Gaps = 15/237 (6%)
Query: 920 NPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEE 979
N CLS PC+N TC D + + C C GF G C+V I C S+PC +GG C +
Sbjct: 433 NECLSGPCRNQATC-LDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVC---KDRV 488
Query: 980 DGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDF 1039
+GF C C GF G C+++VD+C C N + CVD + Y C C + G LC+ +D
Sbjct: 489 NGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDD 548
Query: 1040 CAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYT 1099
C+ D PC H +C+ F C C PGY G C+ D+C+ C++G C D V+ Y
Sbjct: 549 CSPD--PCHH-GRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYL 605
Query: 1100 CICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKC 1156
C CP G +G+ CE + ++PC C++G IN C C PG+ G C
Sbjct: 606 CRCPSGTTGVNCEVNIDDC--ASNPCTFGVCRDG------INRYDCVCQPGFTGPLC 654
Score = 186 bits (472), Expect = 1e-46
Identities = 112/391 (28%), Positives = 161/391 (41%), Gaps = 100/391 (25%)
Query: 855 AIGANP-------------LYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTP 901
+IGANP C C + +++ E C D++
Sbjct: 396 SIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRI----- 450
Query: 902 SKKFTC---QGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPI 958
+FTC G + C S+PC N G C D V+ + CTCP GF G C + +
Sbjct: 451 -GQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCK-DRVNGFSCTCPSGFSGSTCQLDV 508
Query: 959 HACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGIN 1018
C S PC++G C + DG+ C CA+GFEG C+ NVDDC + C ++ CVDGI
Sbjct: 509 DECASTPCRNGAKC---VDQPDGYECRCAEGFEGTLCDRNVDDCSPDPC-HHGRCVDGIA 564
Query: 1019 NYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFD 1078
+++C C P YTG CE ++D C PC+H KC+ + C C G G +C+++ D
Sbjct: 565 SFSCACAPGYTGTRCESQVDECRSQ--PCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNID 622
Query: 1079 DCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFS------------------------ 1114
DC N C G C D +N Y C+C G++G C
Sbjct: 623 DCASNPCTFGV-CRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRC 681
Query: 1115 -------PPMVLPRTSPCDN--------FDCQNGAQCIV-------RINEPI-------- 1144
PP+ LP + PC + +D G +C+ R ++ +
Sbjct: 682 LCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQ 741
Query: 1145 ----------------CQCLPGYQGEKCEKL 1159
C C PG QG +CE L
Sbjct: 742 PCRAGGTCSSDGMGFHCTCPPGVQGRQCELL 772
Score = 182 bits (461), Expect = 3e-45
Identities = 102/311 (32%), Positives = 134/311 (43%), Gaps = 34/311 (10%)
Query: 863 CDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQ---GPVDVNILAKC 919
C C W + + E CAGP + T + F+C G +
Sbjct: 796 CSCPQGWQGPRCQQDVDE-----CAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDI 850
Query: 920 NPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEE 979
N C NPC N G+C D V + C+C GF G C + C+SNPC G TC
Sbjct: 851 NDCDPNPCLNGGSCQ-DGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPG-TC---TDHV 905
Query: 980 DGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDF 1039
F C C G+ G +CE ++ DC + C N TCVDG+N+++CLC P YTG C+ + D
Sbjct: 906 ASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADP 965
Query: 1040 CAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYT 1099
C PC H C GF+C C + G C D C C+NG C G
Sbjct: 966 CLS--RPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQ--TGAY 1021
Query: 1100 CICPEGYSGLFCEFSPPMVLPRTSPCDNFD----------CQNGAQCIVRINEPICQCLP 1149
C+CP G+SG C+ R+ PC CQ G QC+ + C C
Sbjct: 1022 CLCPPGWSGRLCDI-------RSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPE 1074
Query: 1150 GYQGEKCEKLV 1160
G G CE+ V
Sbjct: 1075 GRTGSHCEQEV 1085
Score = 177 bits (448), Expect = 9e-44
Identities = 86/256 (33%), Positives = 119/256 (46%), Gaps = 14/256 (5%)
Query: 906 TCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACIS-N 964
TC V +PC NPC++ G C S P C+CP G++G C + C
Sbjct: 759 TCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPA 818
Query: 965 PCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLC 1024
PC G C G F C C G+ G +C+ +++DC+ N C N +C DG+ +++C C
Sbjct: 819 PCGPHGICTNLAG---SFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSC 875
Query: 1025 PPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNK 1084
P + G C +D C NPC C F C C PGY G HC+ D DC +
Sbjct: 876 LPGFAGPRCARDVDECLS--NPC-GPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSS 932
Query: 1085 CKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPI 1144
C NG C D VN ++C+C GY+G C+ PC + C +G C
Sbjct: 933 CFNGGTCVDGVNSFSCLCRPGYTGAHCQH-------EADPCLSRPCLHGGVCSAAHPGFR 985
Query: 1145 CQCLPGYQGEKCEKLV 1160
C CL + G +C+ LV
Sbjct: 986 CTCLESFTGPQCQTLV 1001
Score = 176 bits (445), Expect = 2e-43
Identities = 119/437 (27%), Positives = 164/437 (37%), Gaps = 125/437 (28%)
Query: 812 RLRCIPPRTFDGLKS------LRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLYCDC 865
R C PR F G L HG SV P+G F C C
Sbjct: 103 RFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRF----------------LCSC 146
Query: 866 NMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQ------GPVDVNILAKC 919
+ +S+ E + G L TP F CQ GP+ N
Sbjct: 147 PPGYQGRSCRSDVDECRVGEPCRHGGTC----LNTPGS-FRCQCPAGYTGPLCENPAV-- 199
Query: 920 NPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDV-----PIHACIS----------- 963
PC +PC+N GTC Y C C GF+GQ+C+V P H C++
Sbjct: 200 -PCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTY 258
Query: 964 ------------------------NPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNV 999
N C +GGTC G G C+C +G+ GE+C N+
Sbjct: 259 NCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLG---GHSCVCVNGWTGESCSQNI 315
Query: 1000 DDCEDNDCENNSTCVDGINNY--------------------------------------- 1020
DDC C + +TC D + ++
Sbjct: 316 DDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRA 375
Query: 1021 TCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDC 1080
C CPP +TG C++ +D C+ NPC+H +C+ T F C C GY G C+ D ++C
Sbjct: 376 ICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNEC 435
Query: 1081 QDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRI 1140
C+N A C D + +TCIC G++G +CE C + C NG C R+
Sbjct: 436 LSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVD-------IDECQSSPCVNGGVCKDRV 488
Query: 1141 NEPICQCLPGYQGEKCE 1157
N C C G+ G C+
Sbjct: 489 NGFSCTCPSGFSGSTCQ 505
Score = 169 bits (429), Expect = 1e-41
Identities = 82/250 (32%), Positives = 119/250 (47%), Gaps = 18/250 (7%)
Query: 918 KCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEG 977
+ +PCLS PC + G C++ F RCTC F G C + C PC++GG C
Sbjct: 962 EADPCLSRPCLHGGVCSAAHPGF-RCTCLESFTGPQCQTLVDWCSRQPCQNGGRC----- 1015
Query: 978 EEDGFWCICADGFEGENCEVNVDDCEDND----------CENNSTCVDGINNYTCLCPPE 1027
+ G +C+C G+ G C++ C + C+ CVD +++ C+CP
Sbjct: 1016 VQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEG 1075
Query: 1028 YTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKN 1087
TG CE+++D C PCQH C G+ C+C PGY G++C+ D D+C C++
Sbjct: 1076 RTGSHCEQEVDPCLAQ--PCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQH 1133
Query: 1088 GAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQC 1147
G C D V Y C CP G G+ CE + P C + C+ + C C
Sbjct: 1134 GGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTC 1193
Query: 1148 LPGYQGEKCE 1157
PGY G +CE
Sbjct: 1194 PPGYTGLRCE 1203
Score = 169 bits (428), Expect = 2e-41
Identities = 88/245 (35%), Positives = 119/245 (48%), Gaps = 19/245 (7%)
Query: 917 AKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKE 976
++ + C S PC++ G C D VD Y C CP G G +C+V I C SNPC G C
Sbjct: 581 SQVDECRSQPCRHGGKC-LDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFG-VCRDGI 638
Query: 977 GEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEK 1036
D C+C GF G C V +++C + C +CVDG N + CLCPP LC
Sbjct: 639 NRYD---CVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPP 695
Query: 1037 LDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHC--DIDFDDCQDNKCKNGAHCTDA 1094
CA + PC H C P GF+C C PG+ G C + D C+ C+ G C+
Sbjct: 696 SHPCAHE--PCSH-GICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSD 752
Query: 1095 VNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINE-PICQCLPGYQG 1153
G+ C CP G G CE SPC C++G +C + P+C C G+QG
Sbjct: 753 GMGFHCTCPPGVQGRQCEL--------LSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQG 804
Query: 1154 EKCEK 1158
+C++
Sbjct: 805 PRCQQ 809
Score = 163 bits (412), Expect = 1e-39
Identities = 87/288 (30%), Positives = 127/288 (44%), Gaps = 58/288 (20%)
Query: 917 AKCNPCLS-NPCKNDGTCNSDP-------------------------------------- 937
A PCL +PC N G C P
Sbjct: 38 AAAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSV 97
Query: 938 ---VDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGEN 994
+ C CP GF+G DC +P C+S+PC HG C + G + F C C G++G +
Sbjct: 98 VAGTARFSCRCPRGFRGPDCSLP-DPCLSSPCAHGARCSV--GPDGRFLCSCPPGYQGRS 154
Query: 995 CEVNVDDCEDND-CENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKC 1053
C +VD+C + C + TC++ ++ C CP YTG LCE CA +PC++ C
Sbjct: 155 CRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAP--SPCRNGGTC 212
Query: 1054 ILT-PKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFC- 1111
+ + C C PG+ G++C+++ DDC ++C NG C D VN Y C CP ++G FC
Sbjct: 213 RQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCT 272
Query: 1112 -EFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEK 1158
+ + P C NG C + C C+ G+ GE C +
Sbjct: 273 EDVDECQLQPNA-------CHNGGTCFNTLGGHSCVCVNGWTGESCSQ 313
Score = 145 bits (366), Expect = 3e-34
Identities = 93/332 (28%), Positives = 130/332 (39%), Gaps = 49/332 (14%)
Query: 863 CDCNMQWLSDWVKSEYKEPGIARCAGPG---EMADKLLLTTPSKKFTCQGPVDVNILAKC 919
C C + +S+ E C G ++ DK L PS G VN
Sbjct: 568 CACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPS------GTTGVNCEVNI 621
Query: 920 NPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEE 979
+ C SNPC G C D ++ Y C C GF G C+V I+ C S+PC GG+C E
Sbjct: 622 DDCASNPC-TFGVCR-DGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSC---VDGE 676
Query: 980 DGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDF 1039
+GF C+C G C C C ++ C D + C+C P ++G C + L
Sbjct: 677 NGFRCLCPPGSLPPLCLPPSHPCAHEPC-SHGICYDAPGGFRCVCEPGWSGPRCSQSLAR 735
Query: 1040 CAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGY- 1098
A + PC+ C GF C C PG G C++ C N C++G C A
Sbjct: 736 DACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCEL-LSPCTPNPCEHGGRCESAPGQLP 794
Query: 1099 TCICPEGYSGLFCE--------------------------------FSPPMVLPRTSPCD 1126
C CP+G+ G C+ ++ P + CD
Sbjct: 795 VCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCD 854
Query: 1127 NFDCQNGAQCIVRINEPICQCLPGYQGEKCEK 1158
C NG C + C CLPG+ G +C +
Sbjct: 855 PNPCLNGGSCQDGVGSFSCSCLPGFAGPRCAR 886
Score = 140 bits (353), Expect = 9e-33
Identities = 86/305 (28%), Positives = 120/305 (39%), Gaps = 62/305 (20%)
Query: 920 NPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEE 979
+PCL+ PC++ GTC + Y C C G+ G +C+ + C S PC+HGG+C
Sbjct: 1086 DPCLAQPCQHGGTCRGY-MGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVAR- 1143
Query: 980 DGFWCICADGFEGENCEVNVDDCEDND-------CENNSTCVDGINNYTCLCPPEYTGEL 1032
+ C C G G CE+N DDC C +N TCVD + + C CPP YTG
Sbjct: 1144 --YLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLR 1201
Query: 1033 CEEKLDFCAQ---------------------------------------DLNPCQHDSKC 1053
CE ++ C + PCQH +C
Sbjct: 1202 CEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQC 1261
Query: 1054 ILTPKG-----FKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSG 1108
+P F C C + G C+ C++ +C G C G C CP G SG
Sbjct: 1262 RPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSG 1321
Query: 1109 LFCEF---SPPMVLPRTSPCDNFDCQNGAQCIVRINEPI--CQCLPGYQGEKCEKLVSVN 1163
C SPP + C C +G C P C C G+ G +CE +
Sbjct: 1322 PSCRSFPGSPPGA--SNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAP 1379
Query: 1164 FINKE 1168
+++E
Sbjct: 1380 EVSEE 1384
Score = 111 bits (278), Expect = 5e-24
Identities = 88/325 (27%), Positives = 122/325 (37%), Gaps = 46/325 (14%)
Query: 863 CDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPVD-VNILAKCN- 920
C+C + D + + E C G D + ++ C P + +L + N
Sbjct: 1108 CECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVA------RYLCSCPPGTLGVLCEINE 1161
Query: 921 -------PCLSNP-CKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTC 972
P S P C ++GTC D V +RCTCP G+ G C+ I+ C S C T
Sbjct: 1162 DDCGPGPPLDSGPRCLHNGTC-VDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTR 1220
Query: 973 HLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTC-----VDGINNYTCLCPPE 1027
+ GF C+C GF G C+ + CE C++ C G +TC C
Sbjct: 1221 DCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQP 1280
Query: 1028 YTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHC--------DIDFDD 1079
+ G CE C + C C TP+G +C C PG G C
Sbjct: 1281 FWGPRCERVARSCRE--LQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNAS 1338
Query: 1080 CQDNKCKNGAHCTDA--VNGYTCICPEGYSGLFCEFSPPMVLPRTSP---CDNFDCQ--- 1131
C C +G C A + C C +G++G CE P P S C CQ
Sbjct: 1339 CAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCE--APAAAPEVSEEPRCPRAACQAKR 1396
Query: 1132 NGAQCIVRINEPICQCLPGYQGEKC 1156
+C N P C G+ G C
Sbjct: 1397 GDQRCDRECNSPGC----GWDGGDC 1417
Score = 83.2 bits (204), Expect = 2e-15
Identities = 50/165 (30%), Positives = 64/165 (38%), Gaps = 14/165 (8%)
Query: 1330 LPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQR-TNDPCLGNKCVHGTCLPI 1388
LP PC + C+HG C + GF C C+ GW GP C Q D C C G
Sbjct: 693 LPPSHPCAHEPCSHGICY-DAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSS 751
Query: 1389 NAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQ-PYCECSSGYTGDSC 1447
+ + C C G G C +L +PC C+HG S GQ P C C G+ G C
Sbjct: 752 DGMGFHCTCPPGVQGRQC----ELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRC 807
Query: 1448 DREI-SCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
+++ C G + C C GG G C
Sbjct: 808 QQDVDECAGP------APCGPHGICTNLAGSFSCTCHGGYTGPSC 846
Score = 80.9 bits (198), Expect = 9e-15
Identities = 53/187 (28%), Positives = 71/187 (37%), Gaps = 20/187 (10%)
Query: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSY 1393
+ C C +G GF+C C G+ G C Q D C C +G Y
Sbjct: 471 DECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTC-QLDVDECASTPCRNGAKCVDQPDGY 529
Query: 1394 SCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREI-S 1452
C+C EG G LCD D C C HG+C + G+ C C+ GYTG C+ ++
Sbjct: 530 ECRCAEGFEGTLCDRNVD---DCSPDPCHHGRC-VDGIASFSCACAPGYTGTRCESQVDE 585
Query: 1453 CRGERIR------DYYQKQQGYAACQTTKKVSRLECR---GGCAGGQCC-GPLRSKRRKY 1502
CR + R D K C+ + + C CA C G R +Y
Sbjct: 586 CRSQPCRHGGKCLDLVDKY----LCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRY 641
Query: 1503 SFECTDG 1509
C G
Sbjct: 642 DCVCQPG 648
Score = 76.6 bits (187), Expect = 2e-13
Identities = 44/121 (36%), Positives = 59/121 (48%), Gaps = 11/121 (9%)
Query: 1334 EPCHKKVCA-HGTCQPSSQAG---FTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPIN 1389
+PCH CA G CQ S AG F+C C G+ GP C DPCL + C HG +
Sbjct: 80 DPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCS--LPDPCLSSPCAHGARCSVG 137
Query: 1390 AFS-YSCKCLEGHGGVLCDEEEDLFNPCQAIK-CKHGKCRLSGLGQPYCECSSGYTGDSC 1447
+ C C G+ G C + D C+ + C+HG L+ G C+C +GYTG C
Sbjct: 138 PDGRFLCSCPPGYQGRSCRSDVD---ECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLC 194
Query: 1448 D 1448
+
Sbjct: 195 E 195
Score = 73.6 bits (179), Expect = 1e-12
Identities = 40/124 (32%), Positives = 54/124 (43%), Gaps = 9/124 (7%)
Query: 1331 PGCEP----CHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCL 1386
P C+ C C +G F+C C G+ GP C R D CL N C GTC
Sbjct: 844 PSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRC-ARDVDECLSNPCGPGTCT 902
Query: 1387 PINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDS 1446
+ S++C C G+GG C+++ C C +G + G+ C C GYTG
Sbjct: 903 D-HVASFTCTCPPGYGGFHCEQD---LPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAH 958
Query: 1447 CDRE 1450
C E
Sbjct: 959 CQHE 962
Score = 73.2 bits (178), Expect = 2e-12
Identities = 46/134 (34%), Positives = 61/134 (45%), Gaps = 11/134 (8%)
Query: 1331 PGC---EPCHKKVCAHGT-CQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVH-GTC 1385
P C +PC CAHG C F C C G+ G C ++ +G C H GTC
Sbjct: 115 PDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTC 174
Query: 1386 LPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKH-GKCRLSGLGQPYCECSSGYTG 1444
L S+ C+C G+ G LC E+ PC C++ G CR SG C C G+ G
Sbjct: 175 LNTPG-SFRCQCPAGYTGPLC---ENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEG 230
Query: 1445 DSCDREI-SCRGER 1457
+C+ + C G R
Sbjct: 231 QNCEVNVDDCPGHR 244
Score = 73.2 bits (178), Expect = 2e-12
Identities = 41/120 (34%), Positives = 54/120 (45%), Gaps = 8/120 (6%)
Query: 1335 PCHKKVCAHG-TCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCV--HGTCLPINAF 1391
PC C HG C+ + C C +GW GP C Q D C G HG C + A
Sbjct: 774 PCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDV-DECAGPAPCGPHGICTNL-AG 831
Query: 1392 SYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREI 1451
S+SC C G+ G CD++ N C C +G G+G C C G+ G C R++
Sbjct: 832 SFSCTCHGGYTGPSCDQD---INDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDV 888
Score = 68.9 bits (167), Expect = 3e-11
Identities = 40/126 (31%), Positives = 60/126 (47%), Gaps = 7/126 (5%)
Query: 1331 PGCE----PCHKKVCAHG-TCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTC 1385
P CE PC C +G TC+ S + C C G+ G C+ +D C G++C++G
Sbjct: 192 PLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDD-CPGHRCLNGGT 250
Query: 1386 LPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGD 1445
+Y+C+C G C E+ D Q C +G + LG C C +G+TG+
Sbjct: 251 CVDGVNTYNCQCPPEWTGQFCTEDVDECQ-LQPNACHNGGTCFNTLGGHSCVCVNGWTGE 309
Query: 1446 SCDREI 1451
SC + I
Sbjct: 310 SCSQNI 315
Score = 68.9 bits (167), Expect = 3e-11
Identities = 39/111 (35%), Positives = 51/111 (45%), Gaps = 10/111 (9%)
Query: 1343 HGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGHG 1402
HG C + F+C C G+ GP CDQ ND C N C++G S+SC CL G
Sbjct: 823 HGICT-NLAGSFSCTCHGGYTGPSCDQDIND-CDPNPCLNGGSCQDGVGSFSCSCLPGFA 880
Query: 1403 GVLC--DEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREI 1451
G C D +E L NPC C + C C GY G C++++
Sbjct: 881 GPRCARDVDECLSNPCGPGTCTDHVASFT------CTCPPGYGGFHCEQDL 925
Score = 68.9 bits (167), Expect = 3e-11
Identities = 43/124 (34%), Positives = 54/124 (43%), Gaps = 17/124 (13%)
Query: 1341 CAHGTCQPSS---QAGFTCECQEGWMGPLCDQRTNDPC----------LGNKCVHGTCLP 1387
C+ CQ Q G C C GW G LCD R+ PC L C G
Sbjct: 1004 CSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSL-PCREAAAQIGVRLEQLCQAGGQCV 1062
Query: 1388 INAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSC 1447
S+ C C EG G C++E D PC A C+HG +G CEC GY GD+C
Sbjct: 1063 DEDSSHYCVCPEGRTGSHCEQEVD---PCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNC 1119
Query: 1448 DREI 1451
+ ++
Sbjct: 1120 EDDV 1123
Score = 68.2 bits (165), Expect = 6e-11
Identities = 53/164 (32%), Positives = 68/164 (41%), Gaps = 25/164 (15%)
Query: 1341 CAHG---TCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCV-HGTC---LPINAFSY 1393
CA+G T PS +A C C GW+G C + DPC C G C + +
Sbjct: 49 CANGGRCTQLPSREAA--CLCPPGWVGERC--QLEDPCHSGPCAGRGVCQSSVVAGTARF 104
Query: 1394 SCKCLEGHGGVLCDEEEDLFNPCQAIKCKHG-KCRLSGLGQPYCECSSGYTGDSCDREI- 1451
SC+C G G C L +PC + C HG +C + G+ C C GY G SC ++
Sbjct: 105 SCRCPRGFRGPDC----SLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVD 160
Query: 1452 SCR-GERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGP 1494
CR GE R C T R +C G G C P
Sbjct: 161 ECRVGEPCRH-------GGTCLNTPGSFRCQCPAGYTGPLCENP 197
Score = 68.2 bits (165), Expect = 6e-11
Identities = 52/164 (31%), Positives = 71/164 (43%), Gaps = 29/164 (17%)
Query: 1330 LPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPIN 1389
LP C P C +G F+C C+ G+ G C Q DPCL C+HG
Sbjct: 925 LPDCSPSS---CFNGGTCVDGVNSFSCLCRPGYTGAHC-QHEADPCLSRPCLHGGVCSAA 980
Query: 1390 AFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKH-GKCRLSGLGQPYCECSSGYTGDSCD 1448
+ C CLE G C + L + C C++ G+C +G YC C G++G CD
Sbjct: 981 HPGFRCTCLESFTGPQC---QTLVDWCSRQPCQNGGRCVQTG---AYCLCPPGWSGRLCD 1034
Query: 1449 -REISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
R + CR AA Q ++ +L C+ AGGQC
Sbjct: 1035 IRSLPCR-------------EAAAQIGVRLEQL-CQ---AGGQC 1061
Score = 64.7 bits (156), Expect = 7e-10
Identities = 54/199 (27%), Positives = 83/199 (41%), Gaps = 20/199 (10%)
Query: 1344 GTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGHGG 1403
GTC ++ G +C C GW G C Q +D C C HG S+ C C G G
Sbjct: 289 GTCF-NTLGGHSCVCVNGWTGESCSQNIDD-CATAVCFHGATCHDRVASFYCACPMGKTG 346
Query: 1404 VLCD-EEEDLFNPCQAIKCKHGKCRLSGL-GQPYCECSSGYTGDSCDREI-SCR-GERIR 1459
+LC ++ + NPC + C + + G+ C C G+TG +CD+++ C G
Sbjct: 347 LLCHLDDACVSNPCH----EDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPC 402
Query: 1460 DYYQK---QQGYAACQTTKKVSRLECR---GGCAGGQCCGPLRSKRRKYSFECTDGSSFV 1513
++ + QG CQ + + C C G C R F C + F
Sbjct: 403 EHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFT 462
Query: 1514 D---EVEKVVKCGCTRCVS 1529
EV+ + +C + CV+
Sbjct: 463 GTYCEVD-IDECQSSPCVN 480
Score = 64.7 bits (156), Expect = 7e-10
Identities = 62/218 (28%), Positives = 86/218 (39%), Gaps = 41/218 (18%)
Query: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCL----PIN 1389
+ C VC HG A F C C G G LC +D C+ N C H + P+N
Sbjct: 316 DDCATAVCFHGATCHDRVASFYCACPMGKTGLLC--HLDDACVSNPC-HEDAICDTNPVN 372
Query: 1390 AFSYSCKCLEGHGGVLCDEEEDL----FNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGD 1445
+ C C G G CD++ D NPC+ + G+C ++ G C+C GYTG
Sbjct: 373 GRAI-CTCPPGFTGGACDQDVDECSIGANPCEHL----GRC-VNTQGSFLCQCGRGYTGP 426
Query: 1446 SCDREIS------CRGERIRDYYQKQQGYAAC-------QTTKKVSRLECRGG-CAGGQC 1491
C+ +++ CR + + G C T +V EC+ C G
Sbjct: 427 RCETDVNECLSGPCRNQAT---CLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGV 483
Query: 1492 CGPLRSKRRKYSFECTDGSSFVDEVEK--VVKCGCTRC 1527
C K R F CT S F + V +C T C
Sbjct: 484 C-----KDRVNGFSCTCPSGFSGSTCQLDVDECASTPC 516
Score = 62.8 bits (151), Expect = 2e-09
Identities = 34/107 (31%), Positives = 48/107 (44%), Gaps = 5/107 (4%)
Query: 1342 AHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGH 1401
A G C + + C C EG G C+Q DPCL C HG Y C+CL G+
Sbjct: 1057 AGGQCVDEDSSHY-CVCPEGRTGSHCEQEV-DPCLAQPCQHGGTCRGYMGGYMCECLPGY 1114
Query: 1402 GGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCD 1448
G C+++ D C + C+HG + + + C C G G C+
Sbjct: 1115 NGDNCEDDVD---ECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCE 1158
Score = 59.7 bits (143), Expect = 2e-08
Identities = 42/160 (26%), Positives = 59/160 (36%), Gaps = 14/160 (8%)
Query: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSY 1393
+ C C G C+ + C CQ G+ GPLC+ N+ C + C G +
Sbjct: 622 DDCASNPCTFGVCRDGINR-YDCVCQPGFTGPLCNVEINE-CASSPCGEGGSCVDGENGF 679
Query: 1394 SCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREISC 1453
C C G LC +PC C HG C G C C G++G C + ++
Sbjct: 680 RCLCPPGSLPPLCLPPS---HPCAHEPCSHGIC-YDAPGGFRCVCEPGWSGPRCSQSLA- 734
Query: 1454 RGERIRDYYQKQ--QGYAACQTTKKVSRLECRGGCAGGQC 1491
RD + Q + C + C G G QC
Sbjct: 735 -----RDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQC 769
Score = 59.3 bits (142), Expect = 3e-08
Identities = 51/162 (31%), Positives = 68/162 (41%), Gaps = 24/162 (14%)
Query: 1341 CAH-GTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGT----CLPINAFSYSC 1395
C H GTC GF C C G+ G C+ N+ C C H CL + C
Sbjct: 1176 CLHNGTCV-DLVGGFRCTCPPGYTGLRCEADINE-CRSGAC-HAAHTRDCLQDPGGGFRC 1232
Query: 1396 KCLEGHGGVLCDEEEDLFNPCQAIKCKH-GKCRLS---GLGQPY-CECSSGYTGDSCDRE 1450
C G G C + + +PC++ C+H G+CR S G G + C C+ + G C+R
Sbjct: 1233 LCHAGFSGPRC---QTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERV 1289
Query: 1451 I-SCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
SCR Q G CQ T + R C G +G C
Sbjct: 1290 ARSCR------ELQCPVG-VPCQQTPRGPRCACPPGLSGPSC 1324
Score = 57.4 bits (137), Expect = 1e-07
Identities = 55/182 (30%), Positives = 71/182 (39%), Gaps = 26/182 (14%)
Query: 1331 PGCE----PCHKKVCAHG-TCQPSSQAG----FTCECQEGWMGPLCDQRTNDPCLGNKCV 1381
P C+ PC + C HG C+PS G FTC C + + GP C +R C +C
Sbjct: 1241 PRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRC-ERVARSCRELQCP 1299
Query: 1382 HGTCLPINAFSYSCKCLEGHGGVLC----DEEEDLFN-PCQAIKCKH-GKCRLSGLGQPY 1435
G C C G G C N C A C H G CR + L +
Sbjct: 1300 VGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFF 1359
Query: 1436 -CECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRL--ECRG-GCA--GG 1489
C C+ G+TG C E + + + + AACQ + R EC GC GG
Sbjct: 1360 RCACAQGWTGPRC--EAPAAAPEVSE--EPRCPRAACQAKRGDQRCDRECNSPGCGWDGG 1415
Query: 1490 QC 1491
C
Sbjct: 1416 DC 1417
Score = 39.7 bits (91), Expect = 0.023
Identities = 34/122 (27%), Positives = 46/122 (37%), Gaps = 31/122 (25%)
Query: 1331 PGCEP------CHKKVCAHG-TCQPSSQAGF-TCECQEGWMGPLCDQRTNDPCLGN--KC 1380
PG P C C HG +C+P+ A F C C +GW GP C+ P + +C
Sbjct: 1328 PGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRC 1387
Query: 1381 VHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKC--KHGKCRLSGLGQPYCEC 1438
C G CD E C + C G C LS +G P+ +C
Sbjct: 1388 PRAA------------CQAKRGDQRCDRE------CNSPGCGWDGGDCSLS-VGDPWRQC 1428
Query: 1439 SS 1440
+
Sbjct: 1429 EA 1430
>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
Length = 1200
Score = 199 bits (507), Expect = 1e-50
Identities = 84/232 (36%), Positives = 126/232 (54%), Gaps = 13/232 (5%)
Query: 925 NPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWC 984
+PC N GTC + D YRCTCP G+ G++C+ HAC SNPC +GG+CH GF C
Sbjct: 315 HPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCH---EVPSGFEC 371
Query: 985 ICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDL 1044
C G+ G C +++D+C N C TCVD ++ + C+CP ++ G C+ ++ C
Sbjct: 372 HCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCR--- 428
Query: 1045 NPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPE 1104
CQH C G++C C G+ G HC+++ D+C + C +G C D +G+ C CP+
Sbjct: 429 GQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQ 488
Query: 1105 GYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKC 1156
G+SG CE + C+ C+NGA+C + C C + G+ C
Sbjct: 489 GFSGPLCEVDVDL-------CEPSPCRNGARCYNLEGDYYCACPDDFGGKNC 533
Score = 177 bits (449), Expect = 7e-44
Identities = 100/319 (31%), Positives = 138/319 (43%), Gaps = 43/319 (13%)
Query: 863 CDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGP---VDVNILAKC 919
C C W + E CA G D++ F C P V
Sbjct: 371 CHCPSGWSGPTCALDIDECASNPCAAGGTCVDQV------DGFECICPEQWVGATCQLDV 424
Query: 920 NPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEE 979
N C C++ GTC D V+ Y+C CP GF G+ C++ C S+PC GG C E
Sbjct: 425 NDCRGQ-CQHGGTCK-DLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLC---EDLA 479
Query: 980 DGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCE----- 1034
DGF C C GF G CEV+VD CE + C N + C + +Y C CP ++ G+ C
Sbjct: 480 DGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREP 539
Query: 1035 ------EKLDFCAQDLNP----------CQHDSKCILTPKG-FKCDCTPGYVGEHCDIDF 1077
+D C D P C +C+ P G F C C G+ G +C +
Sbjct: 540 CPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENI 599
Query: 1078 DDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCI 1137
DDC C+NG C D V+ + C CP G+ G C+ +P LP C + +C
Sbjct: 600 DDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPD-------PCHSRGRCY 652
Query: 1138 VRINEPICQCLPGYQGEKC 1156
+N+ C C G++G+ C
Sbjct: 653 DLVNDFYCACDDGWKGKTC 671
Score = 173 bits (438), Expect = 1e-42
Identities = 86/267 (32%), Positives = 125/267 (46%), Gaps = 17/267 (6%)
Query: 898 LTTPSKKFTC---QGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDC 954
++ P F+C G + CL PC+N GTC D VD +RC CP G++G+ C
Sbjct: 575 VSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTC-IDEVDAFRCFCPSGWEGELC 633
Query: 955 DVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCV 1014
D + C+ +PC G C+ + F+C C DG++G+ C C+ C N TC
Sbjct: 634 DTNPNDCLPDPCHSRGRCYDLVND---FYCACDDGWKGKTCHSREFQCDAYTCSNGGTCY 690
Query: 1015 DGINNYTCLCPPEYTGELCE-EKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHC 1073
D + + C CPP + G C K C NPC + C+ + F C C G+ G C
Sbjct: 691 DSGDTFRCACPPGWKGSTCAVAKNSSCLP--NPCVNGGTCVGSGASFSCICRDGWEGRTC 748
Query: 1074 DIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNG 1133
+ +DC C NG C D VN + C C G++G C + C + C G
Sbjct: 749 THNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRIN-------IDECQSSPCAYG 801
Query: 1134 AQCIVRINEPICQCLPGYQGEKCEKLV 1160
A C+ IN C C PG G +C++++
Sbjct: 802 ATCVDEINGYRCSCPPGRAGPRCQEVI 828
Score = 169 bits (428), Expect = 2e-41
Identities = 81/210 (38%), Positives = 110/210 (52%), Gaps = 14/210 (6%)
Query: 922 CLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDG 981
C SNPC N G+C+ P F C CP G+ G C + I C SNPC GGTC + DG
Sbjct: 351 CTSNPCANGGSCHEVPSGF-ECHCPSGWSGPTCALDIDECASNPCAAGGTC---VDQVDG 406
Query: 982 FWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCA 1041
F CIC + + G C+++V+DC C++ TC D +N Y C+CP + G CE + D CA
Sbjct: 407 FECICPEQWVGATCQLDVNDCR-GQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECA 465
Query: 1042 QDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCI 1101
+PC C GF C C G+ G C++D D C+ + C+NGA C + Y C
Sbjct: 466 S--SPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCA 523
Query: 1102 CPEGYSGLFCEFSPPMVLPRTSPCDNFDCQ 1131
CP+ + G C +PR PC C+
Sbjct: 524 CPDDFGGKNCS------VPR-EPCPGGACR 546
Score = 159 bits (401), Expect = 3e-38
Identities = 77/234 (32%), Positives = 110/234 (47%), Gaps = 13/234 (5%)
Query: 924 SNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFW 983
S C G C S P + C C GF G C I C+ PC++GGTC E D F
Sbjct: 565 SGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCI---DEVDAFR 621
Query: 984 CICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQD 1043
C C G+EGE C+ N +DC + C + C D +N++ C C + G+ C + C D
Sbjct: 622 CFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQC--D 679
Query: 1044 LNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDD-CQDNKCKNGAHCTDAVNGYTCIC 1102
C + C + F+C C PG+ G C + + C N C NG C + ++CIC
Sbjct: 680 AYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCIC 739
Query: 1103 PEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKC 1156
+G+ G C + T+ C+ C NG C+ +N C+C PG+ G C
Sbjct: 740 RDGWEGRTCTHN-------TNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDC 786
Score = 147 bits (370), Expect = 1e-34
Identities = 79/256 (30%), Positives = 108/256 (42%), Gaps = 30/256 (11%)
Query: 922 CLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCK-------------- 967
C +PC+N C + D+Y C CP F G++C VP C C+
Sbjct: 502 CEPSPCRNGARCYNLEGDYY-CACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMP 560
Query: 968 ---HGGTC--HLKEGEEDG--FWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNY 1020
G C H + + G F CIC GF G C N+DDC C N TC+D ++ +
Sbjct: 561 GTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAF 620
Query: 1021 TCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDC 1080
C CP + GELC+ + C D PC +C F C C G+ G+ C C
Sbjct: 621 RCFCPSGWEGELCDTNPNDCLPD--PCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQC 678
Query: 1081 QDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRI 1140
C NG C D+ + + C CP G+ G C + + S C C NG C+
Sbjct: 679 DAYTCSNGGTCYDSGDTFRCACPPGWKGSTC------AVAKNSSCLPNPCVNGGTCVGSG 732
Query: 1141 NEPICQCLPGYQGEKC 1156
C C G++G C
Sbjct: 733 ASFSCICRDGWEGRTC 748
Score = 134 bits (338), Expect = 5e-31
Identities = 71/218 (32%), Positives = 101/218 (46%), Gaps = 24/218 (11%)
Query: 943 CTCPYGFKGQDCDVPIHACISNP-CKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDD 1001
C C YG++G+ CD C+ P C HG + + C C + G C+ +++
Sbjct: 262 CRCSYGWQGRFCD----ECVPYPGCVHGSCV-------EPWQCNCETNWGGLLCDKDLNY 310
Query: 1002 C-EDNDCENNSTCVDGI-NNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKG 1059
C + C N TC++ + Y C CP Y+G CE+ C NPC + C P G
Sbjct: 311 CGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTS--NPCANGGSCHEVPSG 368
Query: 1060 FKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVL 1119
F+C C G+ G C +D D+C N C G C D V+G+ CICPE + G C+
Sbjct: 369 FECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLD----- 423
Query: 1120 PRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCE 1157
+ C CQ+G C +N C C G+ G CE
Sbjct: 424 --VNDCRG-QCQHGGTCKDLVNGYQCVCPRGFGGRHCE 458
Score = 119 bits (298), Expect = 2e-26
Identities = 100/346 (28%), Positives = 135/346 (39%), Gaps = 50/346 (14%)
Query: 805 TLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVP---EGAFNDLSALSHLAIGANPL 861
T I + RC P ++G L + ND P G DL N
Sbjct: 612 TCIDEVDAFRCFCPSGWEG----ELCDTNPNDCLPDPCHSRGRCYDL---------VNDF 658
Query: 862 YCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPV----DVNILA 917
YC C+ W S + C+ G D F C P +A
Sbjct: 659 YCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDS------GDTFRCACPPGWKGSTCAVA 712
Query: 918 KCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEG 977
K + CL NPC N GTC F C C G++G+ C + C PC +GG C
Sbjct: 713 KNSSCLPNPCVNGGTCVGSGASF-SCICRDGWEGRTCTHNTNDCNPLPCYNGGIC----- 766
Query: 978 EEDG---FWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCE 1034
DG F C CA GF G +C +N+D+C+ + C +TCVD IN Y C CPP G C+
Sbjct: 767 -VDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQ 825
Query: 1035 EKLDF---CAQDLNPCQHDSKCILTPKGFKC-----DCTPGYVG-EHCDI-DFDDCQDNK 1084
E + F C P H S + +C DC+ + G + C + + +
Sbjct: 826 EVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQ 885
Query: 1085 CKNGAHCTDAVNGYTCICP--EGYSGLFCEFSPPM-VLPRTSPCDN 1127
C G C + G C+ P E + E P LPR+ DN
Sbjct: 886 CPLGQRCLEKAPG-QCLRPPCEAWGECGAEEPPSTPCLPRSGHLDN 930
Score = 76.3 bits (186), Expect = 2e-13
Identities = 59/196 (30%), Positives = 77/196 (39%), Gaps = 19/196 (9%)
Query: 1336 CHKKVCAHG-TCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVH-GTCLPINAFSY 1393
C C++G TC S F C C GW G C N CL N CV+ GTC+ A S+
Sbjct: 678 CDAYTCSNGGTCYDSGDT-FRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGA-SF 735
Query: 1394 SCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREISC 1453
SC C +G G C N C + C +G + G+ CEC+ G+ G C I
Sbjct: 736 SCICRDGWEGRTCTHNT---NDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINID- 791
Query: 1454 RGERIRDYYQKQQGY-AACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGSSF 1512
+ Y A C R C G AG +C + R +S G+ F
Sbjct: 792 ------ECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWS----RGTPF 841
Query: 1513 VDEVEKVVKCGCTRCV 1528
V C RC+
Sbjct: 842 PHGSSWVEDCNSCRCL 857
Score = 67.4 bits (163), Expect = 1e-10
Identities = 49/157 (31%), Positives = 65/157 (41%), Gaps = 19/157 (12%)
Query: 1340 VCA-HGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVH-GTCLPINAFSYSCKC 1397
VC HG C F+C C G+ G C + +D CLG C + GTC+ ++ C C
Sbjct: 567 VCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDD-CLGQPCRNGGTCID-EVDAFRCFC 624
Query: 1398 LEGHGGVLCDEEED--LFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSC-DREISCR 1454
G G LCD + L +PC + G+C + YC C G+ G +C RE C
Sbjct: 625 PSGWEGELCDTNPNDCLPDPCHS----RGRC-YDLVNDFYCACDDGWKGKTCHSREFQC- 678
Query: 1455 GERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
D Y G C + R C G G C
Sbjct: 679 -----DAYTCSNG-GTCYDSGDTFRCACPPGWKGSTC 709
Score = 65.5 bits (158), Expect = 4e-10
Identities = 49/170 (28%), Positives = 62/170 (36%), Gaps = 23/170 (13%)
Query: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSY 1393
+ C CA G GF C C E W+G C ND C G +C HG Y
Sbjct: 387 DECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVND-CRG-QCQHGGTCKDLVNGY 444
Query: 1394 SCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQP-----YCECSSGYTGDSCD 1448
C C G GG C+ E D +C C GL + +C C G++G C+
Sbjct: 445 QCVCPRGFGGRHCELERD--------ECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCE 496
Query: 1449 REIS------CRGERIRDYYQKQQGYAACQTTKKVSRLEC-RGGCAGGQC 1491
++ CR R Y + Y AC R C GG C
Sbjct: 497 VDVDLCEPSPCR-NGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGAC 545
Score = 63.5 bits (153), Expect = 1e-09
Identities = 50/192 (26%), Positives = 74/192 (38%), Gaps = 36/192 (18%)
Query: 1336 CHKKVCA------HGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPIN 1389
C + VC HG C + C C GW G CD+ P CVHG+C+
Sbjct: 240 CKEAVCKQGCNLLHGGCTVPGE----CRCSYGWQGRFCDECVPYP----GCVHGSCVE-- 289
Query: 1390 AFSYSCKCLEGHGGVLCDEEEDL---FNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDS 1446
+ C C GG+LCD++ + +PC G C + Q C C GY+G +
Sbjct: 290 --PWQCNCETNWGGLLCDKDLNYCGSHHPC----TNGGTCINAEPDQYRCTCPDGYSGRN 343
Query: 1447 CDR-EISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFE 1505
C++ E +C + +C C G +G C + S
Sbjct: 344 CEKAEHACTSNPCAN-------GGSCHEVPSGFECHCPSGWSGPTCALDIDECA---SNP 393
Query: 1506 CTDGSSFVDEVE 1517
C G + VD+V+
Sbjct: 394 CAAGGTCVDQVD 405
Score = 61.6 bits (148), Expect = 6e-09
Identities = 50/172 (29%), Positives = 66/172 (38%), Gaps = 30/172 (17%)
Query: 1341 CAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVH-GTCLPINAFSYSCKCLE 1399
C HG+C Q C C+ W G LCD+ N + C + GTC+ Y C C +
Sbjct: 282 CVHGSCVEPWQ----CNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPD 337
Query: 1400 GHGGVLCDEEED--LFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREIS----- 1452
G+ G C++ E NPC G C G C C SG++G +C +I
Sbjct: 338 GYSGRNCEKAEHACTSNPC----ANGGSCHEVPSGFE-CHCPSGWSGPTCALDIDECASN 392
Query: 1453 --CRGERIRDYYQ-------KQQGYAACQTTKKVSRLECRGGCAGGQCCGPL 1495
G D +Q A CQ +CRG C G C L
Sbjct: 393 PCAAGGTCVDQVDGFECICPEQWVGATCQLDVN----DCRGQCQHGGTCKDL 440
Score = 54.7 bits (130), Expect = 7e-07
Identities = 37/115 (32%), Positives = 45/115 (39%), Gaps = 11/115 (9%)
Query: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKC-VHGTCLPINAFS 1392
+PC GTC A F C C GW G LCD ND CL + C G C +
Sbjct: 605 QPCRNG----GTCIDEVDA-FRCFCPSGWEGELCDTNPND-CLPDPCHSRGRCYDL-VND 657
Query: 1393 YSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSC 1447
+ C C +G G C E C A C +G C C G+ G +C
Sbjct: 658 FYCACDDGWKGKTCHSRE---FQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTC 709
Score = 47.0 bits (110), Expect = 1e-04
Identities = 41/154 (26%), Positives = 58/154 (37%), Gaps = 33/154 (21%)
Query: 1015 DGINNYTC------LCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGY 1068
D +YTC C + G+ C+E + C Q N T G +C C+ G+
Sbjct: 216 DFFGHYTCDQYGNKACMDGWMGKECKEAV--CKQGCNLLHGGC----TVPG-ECRCSYGW 268
Query: 1069 VGEHCD--IDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPC- 1125
G CD + + C C V + C C + GL C+ + C
Sbjct: 269 QGRFCDECVPYPGCVHGSC---------VEPWQCNCETNWGGLLCDKD-------LNYCG 312
Query: 1126 DNFDCQNGAQCI-VRINEPICQCLPGYQGEKCEK 1158
+ C NG CI ++ C C GY G CEK
Sbjct: 313 SHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEK 346
Score = 36.6 bits (83), Expect = 0.19
Identities = 30/119 (25%), Positives = 40/119 (33%), Gaps = 22/119 (18%)
Query: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKC-VHGTCLPINAF- 1391
+ C CA+G G+ C C G GP C + G C GT P +
Sbjct: 791 DECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIG---FGRSCWSRGTPFPHGSSW 847
Query: 1392 ---SYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSC 1447
SC+CL+G C + C C L+ GQP + G C
Sbjct: 848 VEDCNSCRCLDGR------------RDCSKVWCGWKPCLLA--GQPEALSAQCPLGQRC 892
>gi|110735443 delta-like 1 [Homo sapiens]
Length = 723
Score = 199 bits (506), Expect = 2e-50
Identities = 103/294 (35%), Positives = 147/294 (50%), Gaps = 25/294 (8%)
Query: 880 EPGIARC--AGPGEMADKLLLTTPSKKFTCQGPVDVNILAK-----CNPCLS-----NPC 927
+PG +C G D+ + TCQ P N CN L+ PC
Sbjct: 239 KPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPC 298
Query: 928 KNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICA 987
KN TC + Y C+C G+ G C++ I C +PCK+GG+C E+ + C C
Sbjct: 299 KNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSC---TDLENSYSCTCP 355
Query: 988 DGFEGENCEVNVDDCEDNDCENNSTCVDGINN-YTCLCPPEYTGELCEEKLDFCAQDLNP 1046
GF G+ CE++ C D C N C D + Y+C CP Y+G CE+K+D+C+ +P
Sbjct: 356 PGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSS--SP 413
Query: 1047 CQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGY 1106
C + +KC+ + C C G+ G HCD + DDC + C NG C D VN ++C CP GY
Sbjct: 414 CSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGY 473
Query: 1107 SGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKLV 1160
+G C S P+ S C++ C NGA C R + +C+C GY G C+ L+
Sbjct: 474 TGRNC--SAPV-----SRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLL 520
Score = 171 bits (432), Expect = 6e-42
Identities = 82/245 (33%), Positives = 120/245 (48%), Gaps = 17/245 (6%)
Query: 919 CNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISN-PCKHGGTCHLKEG 977
C+ C+ P GTC ++C C G+ G C+ ++ C + PCK+G TC
Sbjct: 254 CDECIRYPGCLHGTCQQP----WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATC--TNT 307
Query: 978 EEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKL 1037
+ + C C G+ G CE+ +D+C+ + C+N +C D N+Y+C CPP + G++CE
Sbjct: 308 GQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSA 367
Query: 1038 DFCAQDLNPCQHDSKCILTPKG-FKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVN 1096
CA PC + +C +P G + C C GY G +C+ D C + C NGA C D +
Sbjct: 368 MTCAD--GPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGD 425
Query: 1097 GYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKC 1156
Y C C G+SG C+ C + C NG C +N+ C C PGY G C
Sbjct: 426 AYLCRCQAGFSGRHCD-------DNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNC 478
Query: 1157 EKLVS 1161
VS
Sbjct: 479 SAPVS 483
Score = 162 bits (409), Expect = 3e-39
Identities = 78/221 (35%), Positives = 112/221 (50%), Gaps = 13/221 (5%)
Query: 906 TCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNP 965
TC+ +D +C+P +PCKN G+C +D + Y CTCP GF G+ C++ C P
Sbjct: 324 TCELGID-----ECDP---SPCKNGGSC-TDLENSYSCTCPPGFYGKICELSAMTCADGP 374
Query: 966 CKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCP 1025
C +GG C + + G+ C C G+ G NCE +D C + C N + CVD + Y C C
Sbjct: 375 CFNGGRC--SDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQ 432
Query: 1026 PEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKC 1085
++G C++ +D CA +PC + C F C C PGY G +C C+ C
Sbjct: 433 AGFSGRHCDDNVDDCAS--SPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPC 490
Query: 1086 KNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCD 1126
NGA C + + Y C C GY G C+F P + P + D
Sbjct: 491 HNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVD 531
Score = 75.9 bits (185), Expect = 3e-13
Identities = 63/210 (30%), Positives = 81/210 (38%), Gaps = 34/210 (16%)
Query: 1330 LPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPIN 1389
LPGC+ HG C + C+C+ GW G CD+ P C+HGTC
Sbjct: 227 LPGCDE------QHGFCDKPGE----CKCRVGWQGRYCDECIRYP----GCLHGTCQQ-- 270
Query: 1390 AFSYSCKCLEGHGGVLCDEEEDLFNPCQAIK-CKHG-KCRLSGLGQPYCECSSGYTG--- 1444
+ C C EG GG+ C+++ N C K CK+G C +G G C C GYTG
Sbjct: 271 --PWQCNCQEGWGGLFCNQD---LNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATC 325
Query: 1445 ----DSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLR---S 1497
D CD G D K+ L CA G C R S
Sbjct: 326 ELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAM-TCADGPCFNGGRCSDS 384
Query: 1498 KRRKYSFECTDGSSFVDEVEKVVKCGCTRC 1527
YS C G S + +K+ C + C
Sbjct: 385 PDGGYSCRCPVGYSGFNCEKKIDYCSSSPC 414
Score = 66.6 bits (161), Expect = 2e-10
Identities = 41/148 (27%), Positives = 58/148 (39%), Gaps = 10/148 (6%)
Query: 1344 GTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGHGG 1403
G C S G++C C G+ G C+++ D C + C +G +Y C+C G G
Sbjct: 379 GRCSDSPDGGYSCRCPVGYSGFNCEKKI-DYCSSSPCSNGAKCVDLGDAYLCRCQAGFSG 437
Query: 1404 VLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREISCRGERIRDYYQ 1463
CD+ D C + C +G G+ C C GYTG +C +S R +
Sbjct: 438 RHCDDNVD---DCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVS------RCEHA 488
Query: 1464 KQQGYAACQTTKKVSRLECRGGCAGGQC 1491
A C EC G G C
Sbjct: 489 PCHNGATCHERGHRYVCECARGYGGPNC 516
Score = 65.1 bits (157), Expect = 5e-10
Identities = 49/193 (25%), Positives = 77/193 (39%), Gaps = 25/193 (12%)
Query: 1332 GCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVH-GTCLPINA 1390
G + C C +G + ++C C G+ G +C+ C C + G C
Sbjct: 328 GIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAM-TCADGPCFNGGRCSDSPD 386
Query: 1391 FSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPY-CECSSGYTGDSCDR 1449
YSC+C G+ G C+++ D C + C +G + LG Y C C +G++G CD
Sbjct: 387 GGYSCRCPVGYSGFNCEKKIDY---CSSSPCSNG-AKCVDLGDAYLCRCQAGFSGRHCDD 442
Query: 1450 EI------------SCRGERIRDY-YQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLR 1496
+ +CR + + D+ GY + VSR E C G C
Sbjct: 443 NVDDCASSPCANGGTCR-DGVNDFSCTCPPGYTGRNCSAPVSRCE-HAPCHNGATC---H 497
Query: 1497 SKRRKYSFECTDG 1509
+ +Y EC G
Sbjct: 498 ERGHRYVCECARG 510
Score = 55.8 bits (133), Expect = 3e-07
Identities = 34/124 (27%), Positives = 49/124 (39%), Gaps = 21/124 (16%)
Query: 1336 CHKKV--CAHGTCQPSSQA-----GFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPI 1388
C KK+ C+ C ++ + C CQ G+ G CD +D C + C +G
Sbjct: 402 CEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDD-CASSPCANGGTCRD 460
Query: 1389 NAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGL----GQPY-CECSSGYT 1443
+SC C G+ G C +C+H C G Y CEC+ GY
Sbjct: 461 GVNDFSCTCPPGYTGRNCS--------APVSRCEHAPCHNGATCHERGHRYVCECARGYG 512
Query: 1444 GDSC 1447
G +C
Sbjct: 513 GPNC 516
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 198 bits (504), Expect = 3e-50
Identities = 107/310 (34%), Positives = 143/310 (46%), Gaps = 33/310 (10%)
Query: 863 CDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPVDVN---ILAKC 919
C C++ W ++E A CA G + PS + C P +
Sbjct: 677 CVCDVGWTGPECEAELGGCISAPCAHGGTCYPQ-----PSG-YNCTCPTGYTGPTCSEEM 730
Query: 920 NPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEE 979
C S PC N G+CN P +Y CTCP G C C+S PC +GGTC + G
Sbjct: 731 TACHSGPCLNGGSCNPSPGGYY-CTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGT- 788
Query: 980 DGFWCICADGFEGENCEVNV-DDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLD 1038
F C+CA GF+G CE + C D+ C N +TC D CLCP YTG C+ +D
Sbjct: 789 --FSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMD 846
Query: 1039 FCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQ----------DNKCKNG 1088
CAQ PC +S C+ T F C C G+ G C++ CQ + C NG
Sbjct: 847 LCAQ--KPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNG 904
Query: 1089 AHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCL 1148
C D+ Y C CP G+ G C+ +PC++ CQNGA C+ + + +CQC
Sbjct: 905 GLCVDSGPSYFCHCPPGFQGSLCQ-------DHVNPCESRPCQNGATCMAQPSGYLCQCA 957
Query: 1149 PGYQGEKCEK 1158
PGY G+ C K
Sbjct: 958 PGYDGQNCSK 967
Score = 184 bits (468), Expect = 4e-46
Identities = 93/282 (32%), Positives = 129/282 (45%), Gaps = 56/282 (19%)
Query: 922 CLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNP---CKHGGTCHLKEGE 978
C+S+ C+N GTC D +D Y C CP + G DC + C + C++GGTC G
Sbjct: 280 CVSHQCQNGGTCQ-DGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGS 338
Query: 979 EDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCP------------- 1025
F C+C G+ G +CE N+DDC C STC+D + +++CLCP
Sbjct: 339 ---FHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDM 395
Query: 1026 --------------------------PEYTGELCEEKLDFC---AQDLNPCQHDSKCILT 1056
P Y+G C + LD C Q +PC+H C+ T
Sbjct: 396 CLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNT 455
Query: 1057 PKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPP 1116
P F C C PGY G C+ D ++C C G+ C D + + C+CP G G CE
Sbjct: 456 PGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEV--- 512
Query: 1117 MVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEK 1158
T+ C + C N A C +N C CLPG+ G +CE+
Sbjct: 513 ----ETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEE 550
Score = 172 bits (437), Expect = 2e-42
Identities = 84/245 (34%), Positives = 120/245 (48%), Gaps = 15/245 (6%)
Query: 920 NPCLSNP--CKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEG 977
N C +P C +C++ + ++C CP G +G C++ C C +GGTC L
Sbjct: 196 NECFQDPGPCPKGTSCHNT-LGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPE 254
Query: 978 EEDGFW-CICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEK 1036
++ F C+C GF G +CEVN D+C + C+N TC DG++ YTCLCP +TG C E
Sbjct: 255 KDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSED 314
Query: 1037 LDFCAQDLNP-CQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAV 1095
+D C P C++ C + F C C G+ G C+ + DDC C G+ C D V
Sbjct: 315 VDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRV 374
Query: 1096 NGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVR--INEPICQCLPGYQG 1153
++C+CP G +GL C C + C AQC +C C PGY G
Sbjct: 375 GSFSCLCPPGRTGLLCHLE--------DMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSG 426
Query: 1154 EKCEK 1158
C +
Sbjct: 427 PTCHQ 431
Score = 169 bits (429), Expect = 1e-41
Identities = 85/246 (34%), Positives = 115/246 (46%), Gaps = 21/246 (8%)
Query: 922 CLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDG 981
C +PC+N TC P RC CP G+ G C + C PC C L+ G
Sbjct: 810 CADSPCRNRATCQDSPQG-PRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHC-LQTGPS-- 865
Query: 982 FWCICADGFEGENCEVNVDDCE----------DNDCENNSTCVDGINNYTCLCPPEYTGE 1031
F C+C G+ G C + + C+ + C N CVD +Y C CPP + G
Sbjct: 866 FHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGS 925
Query: 1032 LCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHC 1091
LC++ ++ C + PCQ+ + C+ P G+ C C PGY G++C + D CQ C N C
Sbjct: 926 LCQDHVNPC--ESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTC 983
Query: 1092 TDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGY 1151
T G+ C CP G+ GL CE L + PC A C N CQCLPG+
Sbjct: 984 TPKPGGFHCACPPGFVGLRCEGDVDECLDQ--PCHP---TGTAACHSLANAFYCQCLPGH 1038
Query: 1152 QGEKCE 1157
G+ CE
Sbjct: 1039 TGQWCE 1044
Score = 168 bits (425), Expect = 4e-41
Identities = 92/301 (30%), Positives = 136/301 (45%), Gaps = 39/301 (12%)
Query: 882 GIARCAGPGEMADKLLLTTPSKKF-TCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDF 940
G A+C+ L L P TC +D ++A+ P +PC++ G+C + P F
Sbjct: 403 GDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGP---SPCEHGGSCLNTPGSF 459
Query: 941 YRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVD 1000
C CP G+ G C+ + C+S PC G TC F C+C G EG+ CEV +
Sbjct: 460 -NCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLAT---FHCLCPPGLEGQLCEVETN 515
Query: 1001 DCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGF 1060
+C C N++ C D +N + C+C P ++G CEE +D C +PC + +C P F
Sbjct: 516 ECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRS--SPCANGGQCQDQPGAF 573
Query: 1061 KCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEF---SPPM 1117
C C PG+ G C + D+C + C GA C D + C+CP G++G CE +P +
Sbjct: 574 HCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNL 633
Query: 1118 VLPR---------------------TSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKC 1156
P+ P DN C +G C C G+ G +C
Sbjct: 634 CQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHG-----HCQRSSCVCDVGWTGPEC 688
Query: 1157 E 1157
E
Sbjct: 689 E 689
Score = 158 bits (400), Expect = 3e-38
Identities = 87/264 (32%), Positives = 112/264 (42%), Gaps = 43/264 (16%)
Query: 922 CLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDG 981
C S+PC N G C P F+ C C GF+G C + C+S+PC G +C G
Sbjct: 555 CRSSPCANGGQCQDQPGAFH-CKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPG---A 610
Query: 982 FWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCP--------PE------ 1027
F+C+C GF G+ CEV + C N C+ C D + CLCP PE
Sbjct: 611 FFCLCPSGFTGQLCEVPL--CAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCH 668
Query: 1028 --------------YTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHC 1073
+TG CE +L C PC H C P G+ C C GY G C
Sbjct: 669 HGHCQRSSCVCDVGWTGPECEAELGGCISA--PCAHGGTCYPQPSGYNCTCPTGYTGPTC 726
Query: 1074 DIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNG 1133
+ C C NG C + GY C CP ++G C+ S T C + C NG
Sbjct: 727 SEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTS-------TDYCVSAPCFNG 779
Query: 1134 AQCIVRINEPICQCLPGYQGEKCE 1157
C+ R C C G+QG +CE
Sbjct: 780 GTCVNRPGTFSCLCAMGFQGPRCE 803
Score = 158 bits (400), Expect = 3e-38
Identities = 79/242 (32%), Positives = 109/242 (45%), Gaps = 21/242 (8%)
Query: 923 LSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGF 982
+S+ C N G C D Y C CP GF+G C ++ C S PC++G TC + G+
Sbjct: 897 VSSLCHNGGLC-VDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCM---AQPSGY 952
Query: 983 WCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQ 1042
C CA G++G+NC +D C+ C N+ TC + C CPP + G CE +D C
Sbjct: 953 LCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLD 1012
Query: 1043 DLNPCQHD--SKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVN---G 1097
PC + C F C C PG+ G+ C+++ D C C +G C G
Sbjct: 1013 Q--PCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLG 1070
Query: 1098 YTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRIN---EPICQCLPGYQGE 1154
+ C CP+G+ G C P C C +G C+ P C CL GY G
Sbjct: 1071 FICHCPKGFEGPTCSHRAP-------SCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGP 1123
Query: 1155 KC 1156
C
Sbjct: 1124 DC 1125
Score = 140 bits (352), Expect = 1e-32
Identities = 80/251 (31%), Positives = 110/251 (43%), Gaps = 29/251 (11%)
Query: 926 PCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDG---- 981
PC N GTC S + C C GF G+ C P + C++GG+C G
Sbjct: 34 PCANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSS 93
Query: 982 -------FWCICADGFEGENCEVNVDD-CEDNDCENNSTC-VDGINNYTCLCPPEYTGEL 1032
F C C GF GE C+ ++D C + C C + C C P +TGE
Sbjct: 94 PSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQ 153
Query: 1033 CEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDC-QD-NKCKNGAH 1090
C+ + DFC+ NPC + C+ T +C C PG+ G C+ D ++C QD C G
Sbjct: 154 CQLR-DFCS--ANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTS 210
Query: 1091 CTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEP----ICQ 1146
C + + + C+CP G G CE R PC C NG C + + +C
Sbjct: 211 CHNTLGSFQCLCPVGQEGPRCEL-------RAGPCPPRGCSNGGTCQLMPEKDSTFHLCL 263
Query: 1147 CLPGYQGEKCE 1157
C PG+ G CE
Sbjct: 264 CPPGFIGPDCE 274
Score = 132 bits (331), Expect = 3e-30
Identities = 82/310 (26%), Positives = 120/310 (38%), Gaps = 73/310 (23%)
Query: 906 TCQGPVDVNILAKCNPCLSNP-CKNDGTCN-------------SDPVDFYRCTCPYGFKG 951
TCQ P +PC + C+N G+C S + CTC GF G
Sbjct: 61 TCQFP---------DPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTG 111
Query: 952 QDCDVPIH-ACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENN 1010
+ C + C + C G CH++ C C G+ GE C++ D C N C N
Sbjct: 112 ERCQAKLEDPCPPSFCSKRGRCHIQASGRPQ--CSCMPGWTGEQCQLR-DFCSANPCVNG 168
Query: 1011 STCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFK--------- 1061
C+ C CPP + G CE ++ C QD PC + C T F+
Sbjct: 169 GVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEG 228
Query: 1062 ---------------------------------CDCTPGYVGEHCDIDFDDCQDNKCKNG 1088
C C PG++G C+++ D+C ++C+NG
Sbjct: 229 PRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNG 288
Query: 1089 AHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCL 1148
C D ++ YTC+CPE ++G C + P C+NG C C C+
Sbjct: 289 GTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPP----HCRNGGTCQNSAGSFHCVCV 344
Query: 1149 PGYQGEKCEK 1158
G+ G CE+
Sbjct: 345 SGWGGTSCEE 354
Score = 111 bits (277), Expect = 6e-24
Identities = 65/214 (30%), Positives = 89/214 (41%), Gaps = 21/214 (9%)
Query: 914 NILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGT-- 971
N + + C S PC N GTC P F+ C CP GF G C+ + C+ PC GT
Sbjct: 964 NCSKELDACQSQPCHNHGTCTPKPGGFH-CACPPGFVGLRCEGDVDECLDQPCHPTGTAA 1022
Query: 972 CHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINN---YTCLCPPEY 1028
CH + F+C C G G+ CEV +D C C + TC + + C CP +
Sbjct: 1023 CH---SLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGF 1079
Query: 1029 TGELCEEKLDFCAQDLNPCQHDSKCILTPK-GF--KCDCTPGYVGEHC---DIDFDDCQD 1082
G C + C + C H C+ +PK GF +C C GY G C
Sbjct: 1080 EGPTCSHRAPSCG--FHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGPP 1137
Query: 1083 NKCKNGAHCTDAVN----GYTCICPEGYSGLFCE 1112
+ C C++ G+ C CP G C+
Sbjct: 1138 SPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQ 1171
Score = 92.0 bits (227), Expect = 4e-18
Identities = 61/187 (32%), Positives = 71/187 (37%), Gaps = 39/187 (20%)
Query: 907 CQGPVDVNILAKCNPCLSNPCKNDGT--CNSDPVDFYRCTCPYGFKGQDCDVPIHACISN 964
C+G VD CL PC GT C+S FY C C G GQ C+V I C S
Sbjct: 1003 CEGDVD--------ECLDQPCHPTGTAACHSLANAFY-CQCLPGHTGQWCEVEIDPCHSQ 1053
Query: 965 PCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNS------------- 1011
PC HGGTC G GF C C GFEG C C + C +
Sbjct: 1054 PCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPR 1113
Query: 1012 -TCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTP----KGFKCDCTP 1066
C+ G CL PP G C +PC ++ C T GF+C C
Sbjct: 1114 CACLSGYGGPDCLTPPAPKG---------CGPP-SPCLYNGSCSETTGLGGPGFRCSCPH 1163
Query: 1067 GYVGEHC 1073
G C
Sbjct: 1164 SSPGPRC 1170
Score = 78.6 bits (192), Expect = 4e-14
Identities = 52/176 (29%), Positives = 71/176 (40%), Gaps = 29/176 (16%)
Query: 1007 CENNSTCVD-GINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCI----------- 1054
C N TC+ + TC C P + GE C+ D C Q+ CQ+ C
Sbjct: 35 CANGGTCLSLSLGQGTCQCAPGFLGETCQFP-DPC-QNAQLCQNGGSCQALLPAPLGLPS 92
Query: 1055 ----LTPKGFKCDCTPGYVGEHCDIDFDD-CQDNKCKNGAHCTDAVNGYT-CICPEGYSG 1108
LTP F C C PG+ GE C +D C + C C +G C C G++G
Sbjct: 93 SPSPLTPS-FLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTG 151
Query: 1109 LFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKLVSVNF 1164
C+ C C NG C+ + C C PG++G CE+ V+ F
Sbjct: 152 EQCQLR--------DFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECF 199
Score = 72.8 bits (177), Expect = 2e-12
Identities = 49/168 (29%), Positives = 68/168 (40%), Gaps = 19/168 (11%)
Query: 1331 PGCEP----CHKKVCAHG-TCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTC 1385
P CE C CAHG TC P +G+ C C G+ GP C + C C++G
Sbjct: 686 PECEAELGGCISAPCAHGGTCYPQP-SGYNCTCPTGYTGPTCSEEMT-ACHSGPCLNGGS 743
Query: 1386 LPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGD 1445
+ Y C C H G C D C + C +G ++ G C C+ G+ G
Sbjct: 744 CNPSPGGYYCTCPPSHTGPQCQTSTDY---CVSAPCFNGGTCVNRPGTFSCLCAMGFQGP 800
Query: 1446 SCDREI--SCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
C+ ++ SC R+ A CQ + + R C G GG C
Sbjct: 801 RCEGKLRPSCADSPCRN-------RATCQDSPQGPRCLCPTGYTGGSC 841
Score = 70.9 bits (172), Expect = 9e-12
Identities = 55/171 (32%), Positives = 71/171 (41%), Gaps = 27/171 (15%)
Query: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGT----CLPIN 1389
+PCH HGTC P GF C C G++G C+ D CL C H T C +
Sbjct: 975 QPCHN----HGTCTPKP-GGFHCACPPGFVGLRCEGDV-DECLDQPC-HPTGTAACHSL- 1026
Query: 1390 AFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQP---YCECSSGYTGDS 1446
A ++ C+CL GH G C+ E D PC + C HG + G P C C G+ G +
Sbjct: 1027 ANAFYCQCLPGHTGQWCEVEID---PCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPT 1083
Query: 1447 CD-REISCRGERIRDYYQKQQGYAACQTTKK--VSRLECRGGCAGGQCCGP 1494
C R SC ++ G + K R C G G C P
Sbjct: 1084 CSHRAPSC------GFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTP 1128
Score = 67.8 bits (164), Expect = 8e-11
Identities = 47/158 (29%), Positives = 66/158 (41%), Gaps = 25/158 (15%)
Query: 1344 GTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGHGG 1403
GTCQ +S F C C GW G C++ +D C+ C G+ S+SC C G G
Sbjct: 330 GTCQ-NSAGSFHCVCVSGWGGTSCEENLDD-CIAATCAPGSTCIDRVGSFSCLCPPGRTG 387
Query: 1404 VLCD-EEEDLFNPCQAIKCKHGKCRLSG---LGQPYCECSSGYTGDSCDREISCRGERIR 1459
+LC E+ L PC HG + S G C C GY+G +C +++
Sbjct: 388 LLCHLEDMCLSQPC------HGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLD------- 434
Query: 1460 DYYQKQQGYAACQ------TTKKVSRLECRGGCAGGQC 1491
+ QQG + C+ T C G G +C
Sbjct: 435 ECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRC 472
Score = 66.6 bits (161), Expect = 2e-10
Identities = 44/169 (26%), Positives = 70/169 (41%), Gaps = 22/169 (13%)
Query: 1336 CHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPC----------LGNKCVHGTC 1385
C +K C + + F C C +GW GPLC+ + C + + C +G
Sbjct: 848 CAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSS-CQKAALSQGIDVSSLCHNGGL 906
Query: 1386 LPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGD 1445
+ SY C C G G LC +D NPC++ C++G ++ C+C+ GY G
Sbjct: 907 CVDSGPSYFCHCPPGFQGSLC---QDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQ 963
Query: 1446 SCDREI-SCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCG 1493
+C +E+ +C+ Q + C C G G +C G
Sbjct: 964 NCSKELDACQS-------QPCHNHGTCTPKPGGFHCACPPGFVGLRCEG 1005
Score = 64.3 bits (155), Expect = 9e-10
Identities = 46/143 (32%), Positives = 64/143 (44%), Gaps = 24/143 (16%)
Query: 1328 GILPGCEPCHKKVCAHG-TCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVH--GT 1384
G+L G P + CA+G TC S TC+C G++G C + DPC + G+
Sbjct: 25 GLLCGSFP---EPCANGGTCLSLSLGQGTCQCAPGFLGETC--QFPDPCQNAQLCQNGGS 79
Query: 1385 C---------LPINAF----SYSCKCLEGHGGVLCDEEEDLFNPCQAIKC-KHGKCRLSG 1430
C LP + S+ C CL G G C + L +PC C K G+C +
Sbjct: 80 CQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAK--LEDPCPPSFCSKRGRCHIQA 137
Query: 1431 LGQPYCECSSGYTGDSCDREISC 1453
G+P C C G+TG+ C C
Sbjct: 138 SGRPQCSCMPGWTGEQCQLRDFC 160
Score = 64.3 bits (155), Expect = 9e-10
Identities = 39/121 (32%), Positives = 53/121 (43%), Gaps = 10/121 (8%)
Query: 1335 PCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKC-VHGTCLPINAFSY 1393
PC + C +G + +G+ C+C G+ G C + D C C HGTC P +
Sbjct: 933 PCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKEL-DACQSQPCHNHGTCTP-KPGGF 990
Query: 1394 SCKCLEGHGGVLC--DEEEDLFNPCQAIKCKHGKCRLSGLGQP-YCECSSGYTGDSCDRE 1450
C C G G+ C D +E L PC G L YC+C G+TG C+ E
Sbjct: 991 HCACPPGFVGLRCEGDVDECLDQPCHPT----GTAACHSLANAFYCQCLPGHTGQWCEVE 1046
Query: 1451 I 1451
I
Sbjct: 1047 I 1047
Score = 62.4 bits (150), Expect = 3e-09
Identities = 45/132 (34%), Positives = 56/132 (42%), Gaps = 23/132 (17%)
Query: 1334 EPCHKKVCAHG-TCQPS--SQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVH-GTCLPI- 1388
+PCH + C HG TC+ + S GF C C +G+ GP C R C + C H G CLP
Sbjct: 1048 DPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRA-PSCGFHHCHHGGLCLPSP 1106
Query: 1389 -NAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKC-------KHGKC-RLSGLGQP--YCE 1437
F C CL G+GG D P C +G C +GLG P C
Sbjct: 1107 KPGFPPRCACLSGYGG------PDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCS 1160
Query: 1438 CSSGYTGDSCDR 1449
C G C +
Sbjct: 1161 CPHSSPGPRCQK 1172
Score = 61.6 bits (148), Expect = 6e-09
Identities = 41/128 (32%), Positives = 55/128 (42%), Gaps = 18/128 (14%)
Query: 1333 CEPCHKKVCAHGTCQPSSQ-----AGFTCECQEGWMGPLCDQRTND----PCLGNKCVHG 1383
CE H + C C P S A F C C G G LC+ TN+ PCL + H
Sbjct: 472 CEADHNE-CLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHD 530
Query: 1384 TCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYT 1443
+N F C CL G G C+E+ D C++ C +G G +C+C G+
Sbjct: 531 L---LNGF--QCICLPGFSGTRCEEDID---ECRSSPCANGGQCQDQPGAFHCKCLPGFE 582
Query: 1444 GDSCDREI 1451
G C E+
Sbjct: 583 GPRCQTEV 590
Score = 60.8 bits (146), Expect = 9e-09
Identities = 47/156 (30%), Positives = 65/156 (41%), Gaps = 20/156 (12%)
Query: 1341 CAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHG-TCLPINAFSYSCKCLE 1399
C HG ++ F C C G+ G C+ N+ CL C G TCL + A ++ C C
Sbjct: 446 CEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNE-CLSQPCHPGSTCLDLLA-TFHCLCPP 503
Query: 1400 GHGGVLCDEEEDLFNPCQAIKC-KHGKCR--LSGLGQPYCECSSGYTGDSCDREI-SCRG 1455
G G LC+ E N C + C H C L+G C C G++G C+ +I CR
Sbjct: 504 GLEGQLCEVET---NECASAPCLNHADCHDLLNGF---QCICLPGFSGTRCEEDIDECRS 557
Query: 1456 ERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
+ Q CQ +C G G +C
Sbjct: 558 SPCANGGQ-------CQDQPGAFHCKCLPGFEGPRC 586
Score = 60.5 bits (145), Expect = 1e-08
Identities = 53/172 (30%), Positives = 65/172 (37%), Gaps = 24/172 (13%)
Query: 1331 PGCEPCHKKVCAH-----GTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVH--- 1382
P CE +H GTCQ +TC C E W G C + D C H
Sbjct: 271 PDCEVNPDNCVSHQCQNGGTCQDGLDT-YTCLCPETWTGWDCSEDV-DECETQGPPHCRN 328
Query: 1383 -GTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSG 1441
GTC +A S+ C C+ G GG C+E D C A C G + +G C C G
Sbjct: 329 GGTCQN-SAGSFHCVCVSGWGGTSCEENLD---DCIAATCAPGSTCIDRVGSFSCLCPPG 384
Query: 1442 YTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKV--SRLECRGGCAGGQC 1491
TG C E C Q G A C T + C+ G +G C
Sbjct: 385 RTGLLCHLEDMCLS-------QPCHGDAQCSTNPLTGSTLCLCQPGYSGPTC 429
Score = 58.9 bits (141), Expect = 4e-08
Identities = 54/201 (26%), Positives = 71/201 (35%), Gaps = 47/201 (23%)
Query: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKC-VHGTCLPINAFS 1392
+ C CA+G F C+C G+ GP C Q D CL + C V +CL + +
Sbjct: 553 DECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRC-QTEVDECLSDPCPVGASCLDLPG-A 610
Query: 1393 YSCKCLEGHGGVLCD----------------EEEDLFN------------PCQAIKCKHG 1424
+ C C G G LC+ +++D N P C HG
Sbjct: 611 FFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHG 670
Query: 1425 KCRLSGLGQPYCECSSGYTGDSCDRE----ISCRGERIRDYYQKQQGY-AACQT-----T 1474
C+ S C C G+TG C+ E IS Y + GY C T T
Sbjct: 671 HCQRSS-----CVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPT 725
Query: 1475 KKVSRLECRGG-CAGGQCCGP 1494
C G C G C P
Sbjct: 726 CSEEMTACHSGPCLNGGSCNP 746
Score = 57.8 bits (138), Expect = 8e-08
Identities = 48/174 (27%), Positives = 73/174 (41%), Gaps = 24/174 (13%)
Query: 1334 EPCHK-KVCAHG-TCQ---------PSSQA----GFTCECQEGWMGPLCDQRTNDPCLGN 1378
+PC ++C +G +CQ PSS + F C C G+ G C + DPC +
Sbjct: 66 DPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPS 125
Query: 1379 KCV-HGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCE 1437
C G C + C C+ G G C L + C A C +G L+ Q C
Sbjct: 126 FCSKRGRCHIQASGRPQCSCMPGWTGEQCQ----LRDFCSANPCVNGGVCLATYPQIQCH 181
Query: 1438 CSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
C G+ G +C+R+++ E +D +G +C T + C G G +C
Sbjct: 182 CPPGFEGHACERDVN---ECFQDPGPCPKG-TSCHNTLGSFQCLCPVGQEGPRC 231
Score = 50.8 bits (120), Expect = 1e-05
Identities = 60/224 (26%), Positives = 82/224 (36%), Gaps = 37/224 (16%)
Query: 1297 PGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTC 1356
PG G H C R+ +N QD PG PC K H T F C
Sbjct: 184 PGFEG---HACERD--VNECFQD-----------PG--PCPKGTSCHNTL-----GSFQC 220
Query: 1357 ECQEGWMGPLCDQRTNDPCLGNKCVH-GTCLPI---NAFSYSCKCLEGHGGVLCDEEEDL 1412
C G GP C+ R PC C + GTC + ++ + C C G G C+ D
Sbjct: 221 LCPVGQEGPRCELRAG-PCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPD- 278
Query: 1413 FNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQ 1472
C + +C++G GL C C +TG C ++ E + + G CQ
Sbjct: 279 --NCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVD-ECETQGPPHCRNGG--TCQ 333
Query: 1473 TTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGSSFVDEV 1516
+ C G G C L + C GS+ +D V
Sbjct: 334 NSAGSFHCVCVSGWGGTSCEENLDD---CIAATCAPGSTCIDRV 374
Score = 32.0 bits (71), Expect = 4.7
Identities = 16/56 (28%), Positives = 26/56 (46%), Gaps = 7/56 (12%)
Query: 1403 GVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREISCRGERI 1458
G+LC + PC G C LGQ C+C+ G+ G++C C+ ++
Sbjct: 25 GLLCGSFPE---PC----ANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQL 73
Score = 31.6 bits (70), Expect = 6.2
Identities = 37/159 (23%), Positives = 54/159 (33%), Gaps = 36/159 (22%)
Query: 919 CNPCLSNPCKNDGTCNSDPV---DFYRCTCPYGFKGQDCDVP-------------IHACI 962
C P +PC +G+C+ +RC+CP+ G C P A
Sbjct: 1134 CGP--PSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPGAKGCEGRSGDGACDAGC 1191
Query: 963 SNPCKH--GGTCHLKEGEEDGF---------WCICADGFEGENCEVNVDDCEDNDCENNS 1011
S P + GG C L G D + W + DG C+ + DCE
Sbjct: 1192 SGPGGNWDGGDCSL--GVPDPWKGCPSHSRCWLLFRDGQCHPQCDSEECLFDGYDCETPP 1249
Query: 1012 TCVDGINNYTCLCPPEYTGELCEEKLDF--CAQDLNPCQ 1048
C + Y C + CE+ + C D C+
Sbjct: 1250 ACTPAYDQY---CHDHFHNGHCEKGCNTAECGWDGGDCR 1285
>gi|9506545 delta-like 4 protein precursor [Homo sapiens]
Length = 685
Score = 196 bits (498), Expect = 1e-49
Identities = 121/370 (32%), Positives = 177/370 (47%), Gaps = 38/370 (10%)
Query: 925 NPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWC 984
+PCKN TC++ Y CTC G+ G DC++ + C SNPC++GG+C + +EDG+ C
Sbjct: 292 SPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSC---KDQEDGYHC 348
Query: 985 ICADGFEGENCEVNVDDCEDNDCENNSTCVDGIN--NYTCLCPPEYTGELCEEKLDFCAQ 1042
+C G+ G +CE + C D+ C N +C + NY C CPP +TG CE+K+D C
Sbjct: 349 LCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTS 408
Query: 1043 DLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCIC 1102
NPC + +C+ C C PG+ G +C++ DC N C +G C D NG C C
Sbjct: 409 --NPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTC 466
Query: 1103 PEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEP--ICQCLPGYQGEKCEKLV 1160
P G+SG CE V C + C N A C ++ +C C G+ G +CE V
Sbjct: 467 PAGFSGRRCE-----VRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPV 521
Query: 1161 SVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVELYRGRVRASYD 1220
+ PS P ++L + + +L+ G +AV + + R+R D
Sbjct: 522 GLP----------PSF---PWVAVSLGVGL---AVLLVLLG---MVAVAVRQLRLRRP-D 561
Query: 1221 TGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQSTLNFD---S 1277
GS A S + D +L +Q L VD G K + TL+++
Sbjct: 562 DGSREAMNNLS-DFQKDNLIPAAQLKNTNQKKELEVDCGLDKSNCGKQQNHTLDYNLAPG 620
Query: 1278 PLYVGGMPGK 1287
PL G MPGK
Sbjct: 621 PLGRGTMPGK 630
Score = 162 bits (409), Expect = 3e-39
Identities = 79/248 (31%), Positives = 118/248 (47%), Gaps = 18/248 (7%)
Query: 919 CNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISN-PCKHGGTCHLKEG 977
CN C+ + GTC++ ++CTC G+ G CD ++ C + PCK+G TC
Sbjct: 250 CNECIPHNGCRHGTCSTP----WQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATC--SNS 303
Query: 978 EEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKL 1037
+ + C C G+ G +CE+ + +C+ N C N +C D + Y CLCPP Y G CE
Sbjct: 304 GQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHST 363
Query: 1038 DFCAQDLNPCQHDSKCILTPKG--FKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAV 1095
CA +PC + C +G + C+C P + G +C+ D C N C NG C +
Sbjct: 364 LSCAD--SPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRG 421
Query: 1096 NGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEK 1155
C C G++G +CE S C C +G C N +C C G+ G +
Sbjct: 422 PSRMCRCRPGFTGTYCEL-------HVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRR 474
Query: 1156 CEKLVSVN 1163
CE S++
Sbjct: 475 CEVRTSID 482
Score = 145 bits (367), Expect = 2e-34
Identities = 90/260 (34%), Positives = 126/260 (48%), Gaps = 39/260 (15%)
Query: 907 CQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACIS-NP 965
CQ P+ CLS + +G C S P + C C G++G+ C+ CI N
Sbjct: 217 CQQPI----------CLSGCHEQNGYC-SKPAE---CLCRPGWQGRLCN----ECIPHNG 258
Query: 966 CKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDND-CENNSTCVD-GINNYTCL 1023
C+HG TC + C C +G+ G C+ +++ C + C+N +TC + G +YTC
Sbjct: 259 CRHG-TCSTP------WQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCT 311
Query: 1024 CPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDN 1083
C P YTG CE +L C D NPC++ C G+ C C PGY G HC+ C D+
Sbjct: 312 CRPGYTGVDCELELSEC--DSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADS 369
Query: 1084 KCKNGAHCTDAVNG--YTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRIN 1141
C NG C + G Y C CP ++G CE + C + C NG QC+ R
Sbjct: 370 PCFNGGSCRERNQGANYACECPPNFTGSNCE-------KKVDRCTSNPCANGGQCLNRGP 422
Query: 1142 EPICQCLPGYQGEKCEKLVS 1161
+C+C PG+ G CE VS
Sbjct: 423 SRMCRCRPGFTGTYCELHVS 442
Score = 113 bits (282), Expect = 2e-24
Identities = 71/237 (29%), Positives = 92/237 (38%), Gaps = 68/237 (28%)
Query: 985 ICADGFEGENCEVNVDDCEDN------DCENNSTCVDG-----------------INNY- 1020
IC+D + G+NC D+ + N +C+ G N Y
Sbjct: 174 ICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYC 233
Query: 1021 ----TCLCPPEYTGELCEEKLD------------------------FCAQDLNPCQHDSK 1052
CLC P + G LC E + FC QDLN C H S
Sbjct: 234 SKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSP 293
Query: 1053 C-------ILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEG 1105
C + + C C PGY G C+++ +C N C+NG C D +GY C+CP G
Sbjct: 294 CKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPG 353
Query: 1106 YSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRIN--EPICQCLPGYQGEKCEKLV 1160
Y GL CE S T C + C NG C R C+C P + G CEK V
Sbjct: 354 YYGLHCEHS-------TLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKV 403
Score = 74.7 bits (182), Expect = 6e-13
Identities = 67/219 (30%), Positives = 91/219 (41%), Gaps = 33/219 (15%)
Query: 1330 LPGC--EPCHKKVCAHGTCQPSSQAG--FTCECQEGWMGPLCDQRTNDPCLGNKCVHGTC 1385
LPG E C + +C G + + C C+ GW G LC N+ N C HGTC
Sbjct: 209 LPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLC----NECIPHNGCRHGTC 264
Query: 1386 LPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHG-KCRLSGLGQPYCECSSGYTG 1444
+ + C C EG GG+ CD +DL CK+G C SG C C GYTG
Sbjct: 265 ----STPWQCTCDEGWGGLFCD--QDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTG 318
Query: 1445 DSCDREIS------CR-GERIRDYYQKQQGYAACQTTKKVSRLECRG---GCAGGQCC-- 1492
C+ E+S CR G +D ++ GY C L C CA C
Sbjct: 319 VDCELELSECDSNPCRNGGSCKD---QEDGY-HCLCPPGYYGLHCEHSTLSCADSPCFNG 374
Query: 1493 GPLRSKRR--KYSFECTDGSSFVDEVEKVVKCGCTRCVS 1529
G R + + Y+ EC + + +KV +C C +
Sbjct: 375 GSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCAN 413
Score = 72.0 bits (175), Expect = 4e-12
Identities = 60/185 (32%), Positives = 75/185 (40%), Gaps = 26/185 (14%)
Query: 1341 CAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHG-TCLPINAFSYSCKCLE 1399
C HGTC Q C C EGW G CDQ N + C +G TC SY+C C
Sbjct: 259 CRHGTCSTPWQ----CTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRP 314
Query: 1400 GHGGVLCDEEEDLFNPCQAIKCKH-GKCRLSGLGQPYCECSSGYTGDSCDRE-ISC---- 1453
G+ GV C+ E + C + C++ G C+ G +C C GY G C+ +SC
Sbjct: 315 GYTGVDCELE---LSECDSNPCRNGGSCKDQEDGY-HCLCPPGYYGLHCEHSTLSCADSP 370
Query: 1454 --RGERIRDYYQKQQGYAAC-------QTTKKVSRLECRGGCAGGQCC--GPLRSKRRKY 1502
G R+ Q C KKV R GGQC GP R R +
Sbjct: 371 CFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRP 430
Query: 1503 SFECT 1507
F T
Sbjct: 431 GFTGT 435
Score = 53.1 bits (126), Expect = 2e-06
Identities = 37/135 (27%), Positives = 58/135 (42%), Gaps = 12/135 (8%)
Query: 1324 PMQTGILPGCE----PCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNK 1379
P TG+ CE C C +G + G+ C C G+ G C+ T C +
Sbjct: 314 PGYTGV--DCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLS-CADSP 370
Query: 1380 CVH-GTCLPIN-AFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCE 1437
C + G+C N +Y+C+C G C+++ D C + C +G L+ C
Sbjct: 371 CFNGGSCRERNQGANYACECPPNFTGSNCEKKVD---RCTSNPCANGGQCLNRGPSRMCR 427
Query: 1438 CSSGYTGDSCDREIS 1452
C G+TG C+ +S
Sbjct: 428 CRPGFTGTYCELHVS 442
Score = 46.2 bits (108), Expect = 2e-04
Identities = 33/123 (26%), Positives = 46/123 (37%), Gaps = 13/123 (10%)
Query: 1336 CHKKV--CAHGTCQPSSQA-----GFTCECQEGWMGPLCDQRTNDPCLGNKCVH-GTCLP 1387
C KKV C C Q C C+ G+ G C+ +D C N C H GTC
Sbjct: 399 CEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSD-CARNPCAHGGTCHD 457
Query: 1388 INAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQP--YCECSSGYTGD 1445
+ C C G G C+ + + C + C + + L C C G+ G
Sbjct: 458 LEN-GLMCTCPAGFSGRRCEVRTSI-DACASSPCFNRATCYTDLSTDTFVCNCPYGFVGS 515
Query: 1446 SCD 1448
C+
Sbjct: 516 RCE 518
Score = 45.4 bits (106), Expect = 4e-04
Identities = 18/38 (47%), Positives = 23/38 (60%), Gaps = 1/38 (2%)
Query: 922 CLSNPCKNDGTCNSD-PVDFYRCTCPYGFKGQDCDVPI 958
C S+PC N TC +D D + C CPYGF G C+ P+
Sbjct: 484 CASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPV 521
Score = 33.1 bits (74), Expect = 2.1
Identities = 36/160 (22%), Positives = 51/160 (31%), Gaps = 65/160 (40%)
Query: 1008 ENNSTCVDGINNYTCLCPPEYTGE----LCEEKLDFCAQDLNPCQHDSKCILTPKGFKCD 1063
E ST +Y +C Y G+ LC+++ D H + P G
Sbjct: 159 EQTSTLTRLRYSYRVICSDNYYGDNCSRLCKKRND----------HFGHYVCQPDG-NLS 207
Query: 1064 CTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTS 1123
C PG+ GE+C Q C +G H NGY
Sbjct: 208 CLPGWTGEYC-------QQPICLSGCH---EQNGY------------------------- 232
Query: 1124 PCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKLVSVN 1163
C A+C+ C PG+QG C + + N
Sbjct: 233 ------CSKPAECL---------CRPGWQGRLCNECIPHN 257
>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
Length = 1238
Score = 196 bits (498), Expect = 1e-49
Identities = 87/233 (37%), Positives = 125/233 (53%), Gaps = 13/233 (5%)
Query: 925 NPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWC 984
+PC N GTC + D YRCTCP G+ G++C+ HAC SNPC +GG+CH GF C
Sbjct: 315 HPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCH---EVPSGFEC 371
Query: 985 ICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDL 1044
C G+ G C +++D+C N C TCVD ++ + C+CP ++ G C+ + C +
Sbjct: 372 HCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANEC--EG 429
Query: 1045 NPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPE 1104
PC + C G+ CDC PG+ G +C I+ +DC+ +C++G C D VNGY C+CP
Sbjct: 430 KPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCR-GQCQHGGTCKDLVNGYQCVCPR 488
Query: 1105 GYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCE 1157
G+ G CE C + C +G C + C C G+ G CE
Sbjct: 489 GFGGRHCEL-------ERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCE 534
Score = 174 bits (441), Expect = 6e-43
Identities = 89/266 (33%), Positives = 125/266 (46%), Gaps = 34/266 (12%)
Query: 913 VNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTC 972
+N N C C++ GTC D V+ Y+C CP GF G+ C++ C S+PC GG C
Sbjct: 456 INCHINVNDCRGQ-CQHGGTCK-DLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLC 513
Query: 973 HLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGEL 1032
E DGF C C GF G CEV+VD CE + C N + C + +Y C CP ++ G+
Sbjct: 514 ---EDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKN 570
Query: 1033 CE-----------EKLDFCAQDLNP----------CQHDSKCILTPKG-FKCDCTPGYVG 1070
C +D C D P C +C+ P G F C C G+ G
Sbjct: 571 CSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTG 630
Query: 1071 EHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDC 1130
+C + DDC C+NG C D V+ + C CP G+ G C+ +P LP C
Sbjct: 631 TYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPD-------PC 683
Query: 1131 QNGAQCIVRINEPICQCLPGYQGEKC 1156
+ +C +N+ C C G++G+ C
Sbjct: 684 HSRGRCYDLVNDFYCACDDGWKGKTC 709
Score = 173 bits (438), Expect = 1e-42
Identities = 86/267 (32%), Positives = 125/267 (46%), Gaps = 17/267 (6%)
Query: 898 LTTPSKKFTC---QGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDC 954
++ P F+C G + CL PC+N GTC D VD +RC CP G++G+ C
Sbjct: 613 VSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTC-IDEVDAFRCFCPSGWEGELC 671
Query: 955 DVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCV 1014
D + C+ +PC G C+ + F+C C DG++G+ C C+ C N TC
Sbjct: 672 DTNPNDCLPDPCHSRGRCYDLVND---FYCACDDGWKGKTCHSREFQCDAYTCSNGGTCY 728
Query: 1015 DGINNYTCLCPPEYTGELCE-EKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHC 1073
D + + C CPP + G C K C NPC + C+ + F C C G+ G C
Sbjct: 729 DSGDTFRCACPPGWKGSTCAVAKNSSCLP--NPCVNGGTCVGSGASFSCICRDGWEGRTC 786
Query: 1074 DIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNG 1133
+ +DC C NG C D VN + C C G++G C + C + C G
Sbjct: 787 THNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRIN-------IDECQSSPCAYG 839
Query: 1134 AQCIVRINEPICQCLPGYQGEKCEKLV 1160
A C+ IN C C PG G +C++++
Sbjct: 840 ATCVDEINGYRCSCPPGRAGPRCQEVI 866
Score = 159 bits (401), Expect = 3e-38
Identities = 77/234 (32%), Positives = 110/234 (47%), Gaps = 13/234 (5%)
Query: 924 SNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFW 983
S C G C S P + C C GF G C I C+ PC++GGTC E D F
Sbjct: 603 SGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCI---DEVDAFR 659
Query: 984 CICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQD 1043
C C G+EGE C+ N +DC + C + C D +N++ C C + G+ C + C D
Sbjct: 660 CFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQC--D 717
Query: 1044 LNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDD-CQDNKCKNGAHCTDAVNGYTCIC 1102
C + C + F+C C PG+ G C + + C N C NG C + ++CIC
Sbjct: 718 AYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCIC 777
Query: 1103 PEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKC 1156
+G+ G C + T+ C+ C NG C+ +N C+C PG+ G C
Sbjct: 778 RDGWEGRTCTHN-------TNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDC 824
Score = 147 bits (370), Expect = 1e-34
Identities = 79/256 (30%), Positives = 108/256 (42%), Gaps = 30/256 (11%)
Query: 922 CLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCK-------------- 967
C +PC+N C + D+Y C CP F G++C VP C C+
Sbjct: 540 CEPSPCRNGARCYNLEGDYY-CACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMP 598
Query: 968 ---HGGTC--HLKEGEEDG--FWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNY 1020
G C H + + G F CIC GF G C N+DDC C N TC+D ++ +
Sbjct: 599 GTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAF 658
Query: 1021 TCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDC 1080
C CP + GELC+ + C D PC +C F C C G+ G+ C C
Sbjct: 659 RCFCPSGWEGELCDTNPNDCLPD--PCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQC 716
Query: 1081 QDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRI 1140
C NG C D+ + + C CP G+ G C + + S C C NG C+
Sbjct: 717 DAYTCSNGGTCYDSGDTFRCACPPGWKGSTC------AVAKNSSCLPNPCVNGGTCVGSG 770
Query: 1141 NEPICQCLPGYQGEKC 1156
C C G++G C
Sbjct: 771 ASFSCICRDGWEGRTC 786
Score = 139 bits (350), Expect = 2e-32
Identities = 72/224 (32%), Positives = 105/224 (46%), Gaps = 25/224 (11%)
Query: 943 CTCPYGFKGQDCDVPIHACISNP-CKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDD 1001
C C YG++G+ CD C+ P C HG + + C C + G C+ +++
Sbjct: 262 CRCSYGWQGRFCD----ECVPYPGCVHGSCV-------EPWQCNCETNWGGLLCDKDLNY 310
Query: 1002 C-EDNDCENNSTCVDGI-NNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKG 1059
C + C N TC++ + Y C CP Y+G CE+ C NPC + C P G
Sbjct: 311 CGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTS--NPCANGGSCHEVPSG 368
Query: 1060 FKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVL 1119
F+C C G+ G C +D D+C N C G C D V+G+ CICPE + G C+
Sbjct: 369 FECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLD----- 423
Query: 1120 PRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKLVSVN 1163
+ C+ C N C I C C+PG++G C ++VN
Sbjct: 424 --ANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCH--INVN 463
Score = 119 bits (298), Expect = 2e-26
Identities = 100/346 (28%), Positives = 135/346 (39%), Gaps = 50/346 (14%)
Query: 805 TLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVP---EGAFNDLSALSHLAIGANPL 861
T I + RC P ++G L + ND P G DL N
Sbjct: 650 TCIDEVDAFRCFCPSGWEG----ELCDTNPNDCLPDPCHSRGRCYDL---------VNDF 696
Query: 862 YCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPV----DVNILA 917
YC C+ W S + C+ G D F C P +A
Sbjct: 697 YCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDS------GDTFRCACPPGWKGSTCAVA 750
Query: 918 KCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEG 977
K + CL NPC N GTC F C C G++G+ C + C PC +GG C
Sbjct: 751 KNSSCLPNPCVNGGTCVGSGASF-SCICRDGWEGRTCTHNTNDCNPLPCYNGGIC----- 804
Query: 978 EEDG---FWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCE 1034
DG F C CA GF G +C +N+D+C+ + C +TCVD IN Y C CPP G C+
Sbjct: 805 -VDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQ 863
Query: 1035 EKLDF---CAQDLNPCQHDSKCILTPKGFKC-----DCTPGYVG-EHCDI-DFDDCQDNK 1084
E + F C P H S + +C DC+ + G + C + + +
Sbjct: 864 EVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQ 923
Query: 1085 CKNGAHCTDAVNGYTCICP--EGYSGLFCEFSPPM-VLPRTSPCDN 1127
C G C + G C+ P E + E P LPR+ DN
Sbjct: 924 CPLGQRCLEKAPG-QCLRPPCEAWGECGAEEPPSTPCLPRSGHLDN 968
Score = 76.3 bits (186), Expect = 2e-13
Identities = 59/196 (30%), Positives = 77/196 (39%), Gaps = 19/196 (9%)
Query: 1336 CHKKVCAHG-TCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVH-GTCLPINAFSY 1393
C C++G TC S F C C GW G C N CL N CV+ GTC+ A S+
Sbjct: 716 CDAYTCSNGGTCYDSGDT-FRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGA-SF 773
Query: 1394 SCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREISC 1453
SC C +G G C N C + C +G + G+ CEC+ G+ G C I
Sbjct: 774 SCICRDGWEGRTCTHNT---NDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINID- 829
Query: 1454 RGERIRDYYQKQQGY-AACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGSSF 1512
+ Y A C R C G AG +C + R +S G+ F
Sbjct: 830 ------ECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWS----RGTPF 879
Query: 1513 VDEVEKVVKCGCTRCV 1528
V C RC+
Sbjct: 880 PHGSSWVEDCNSCRCL 895
Score = 67.4 bits (163), Expect = 1e-10
Identities = 49/157 (31%), Positives = 65/157 (41%), Gaps = 19/157 (12%)
Query: 1340 VCA-HGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVH-GTCLPINAFSYSCKC 1397
VC HG C F+C C G+ G C + +D CLG C + GTC+ ++ C C
Sbjct: 605 VCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDD-CLGQPCRNGGTCID-EVDAFRCFC 662
Query: 1398 LEGHGGVLCDEEED--LFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSC-DREISCR 1454
G G LCD + L +PC + G+C + YC C G+ G +C RE C
Sbjct: 663 PSGWEGELCDTNPNDCLPDPCHS----RGRC-YDLVNDFYCACDDGWKGKTCHSREFQC- 716
Query: 1455 GERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
D Y G C + R C G G C
Sbjct: 717 -----DAYTCSNG-GTCYDSGDTFRCACPPGWKGSTC 747
Score = 65.5 bits (158), Expect = 4e-10
Identities = 44/157 (28%), Positives = 59/157 (37%), Gaps = 13/157 (8%)
Query: 1336 CHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSC 1395
C CA+G +GF C C GW GP C D C N C G + C
Sbjct: 351 CTSNPCANGGSCHEVPSGFECHCPSGWSGPTC-ALDIDECASNPCAAGGTCVDQVDGFEC 409
Query: 1396 KCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREIS-CR 1454
C E G C + N C+ C + + +G YC+C G+ G +C ++ CR
Sbjct: 410 ICPEQWVGATCQLDA---NECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCR 466
Query: 1455 GERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
G Q Q G C+ + C G G C
Sbjct: 467 G-------QCQHG-GTCKDLVNGYQCVCPRGFGGRHC 495
Score = 63.5 bits (153), Expect = 1e-09
Identities = 50/192 (26%), Positives = 74/192 (38%), Gaps = 36/192 (18%)
Query: 1336 CHKKVCA------HGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPIN 1389
C + VC HG C + C C GW G CD+ P CVHG+C+
Sbjct: 240 CKEAVCKQGCNLLHGGCTVPGE----CRCSYGWQGRFCDECVPYP----GCVHGSCVE-- 289
Query: 1390 AFSYSCKCLEGHGGVLCDEEEDL---FNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDS 1446
+ C C GG+LCD++ + +PC G C + Q C C GY+G +
Sbjct: 290 --PWQCNCETNWGGLLCDKDLNYCGSHHPC----TNGGTCINAEPDQYRCTCPDGYSGRN 343
Query: 1447 CDR-EISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFE 1505
C++ E +C + +C C G +G C + S
Sbjct: 344 CEKAEHACTSNPCAN-------GGSCHEVPSGFECHCPSGWSGPTCALDIDECA---SNP 393
Query: 1506 CTDGSSFVDEVE 1517
C G + VD+V+
Sbjct: 394 CAAGGTCVDQVD 405
Score = 57.4 bits (137), Expect = 1e-07
Identities = 34/118 (28%), Positives = 48/118 (40%), Gaps = 10/118 (8%)
Query: 1336 CHKKV------CAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPIN 1389
CH V C HG G+ C C G+ G C+ D C + C G
Sbjct: 458 CHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELE-RDECASSPCHSGGLCEDL 516
Query: 1390 AFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSC 1447
A + C C +G G LC+ + DL C+ C++G + G YC C + G +C
Sbjct: 517 ADGFHCHCPQGFSGPLCEVDVDL---CEPSPCRNGARCYNLEGDYYCACPDDFGGKNC 571
Score = 56.6 bits (135), Expect = 2e-07
Identities = 43/152 (28%), Positives = 59/152 (38%), Gaps = 36/152 (23%)
Query: 1335 PCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGT-CLPINAFSY 1393
PCH + G C+ + GF C C +G+ GPLC+ D C + C +G C + Y
Sbjct: 506 PCH----SGGLCEDLAD-GFHCHCPQGFSGPLCEVDV-DLCEPSPCRNGARCYNLEG-DY 558
Query: 1394 SCKCLEGHGGVLCDEEEDLFNPCQAIKCK------------------------HGKCRLS 1429
C C + GG C + PC C+ HG+C
Sbjct: 559 YCACPDDFGGKNCSVPRE---PCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQ 615
Query: 1430 GLGQPYCECSSGYTGDSCDREI-SCRGERIRD 1460
G C C SG+TG C I C G+ R+
Sbjct: 616 PGGNFSCICDSGFTGTYCHENIDDCLGQPCRN 647
Score = 55.8 bits (133), Expect = 3e-07
Identities = 33/117 (28%), Positives = 46/117 (39%), Gaps = 5/117 (4%)
Query: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSY 1393
+ C CA G GF C C E W+G C N+ C G C++ Y
Sbjct: 387 DECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANE-CEGKPCLNAFSCKNLIGGY 445
Query: 1394 SCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDRE 1450
C C+ G G+ C N C+ +C+HG + C C G+ G C+ E
Sbjct: 446 YCDCIPGWKGINCHIN---VNDCRG-QCQHGGTCKDLVNGYQCVCPRGFGGRHCELE 498
Score = 54.7 bits (130), Expect = 7e-07
Identities = 37/115 (32%), Positives = 45/115 (39%), Gaps = 11/115 (9%)
Query: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKC-VHGTCLPINAFS 1392
+PC GTC A F C C GW G LCD ND CL + C G C +
Sbjct: 643 QPCRNG----GTCIDEVDA-FRCFCPSGWEGELCDTNPND-CLPDPCHSRGRCYDL-VND 695
Query: 1393 YSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSC 1447
+ C C +G G C E C A C +G C C G+ G +C
Sbjct: 696 FYCACDDGWKGKTCHSRE---FQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTC 747
Score = 48.1 bits (113), Expect = 6e-05
Identities = 45/181 (24%), Positives = 62/181 (34%), Gaps = 53/181 (29%)
Query: 1015 DGINNYTC------LCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGY 1068
D +YTC C + G+ C+E + C Q N T G +C C+ G+
Sbjct: 216 DFFGHYTCDQYGNKACMDGWMGKECKEAV--CKQGCNLLHGGC----TVPG-ECRCSYGW 268
Query: 1069 VGEHCD--IDFDDC------------------------------QDNKCKNGAHCTDA-V 1095
G CD + + C + C NG C +A
Sbjct: 269 QGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEP 328
Query: 1096 NGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEK 1155
+ Y C CP+GYSG CE C + C NG C + C C G+ G
Sbjct: 329 DQYRCTCPDGYSGRNCE-------KAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPT 381
Query: 1156 C 1156
C
Sbjct: 382 C 382
Score = 36.6 bits (83), Expect = 0.19
Identities = 30/119 (25%), Positives = 40/119 (33%), Gaps = 22/119 (18%)
Query: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKC-VHGTCLPINAF- 1391
+ C CA+G G+ C C G GP C + G C GT P +
Sbjct: 829 DECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIG---FGRSCWSRGTPFPHGSSW 885
Query: 1392 ---SYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSC 1447
SC+CL+G C + C C L+ GQP + G C
Sbjct: 886 VEDCNSCRCLDGR------------RDCSKVWCGWKPCLLA--GQPEALSAQCPLGQRC 930
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 194 bits (492), Expect = 7e-49
Identities = 88/243 (36%), Positives = 123/243 (50%), Gaps = 13/243 (5%)
Query: 922 CLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDG 981
C NPC N GTC Y C CP G+ G C+ I C PC + G C GE
Sbjct: 1197 CFFNPCHNSGTCQQLGRG-YVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGE--- 1252
Query: 982 FWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCA 1041
F C C G+ G+ CE N+++C + C N CVDG+ Y C C + G CE +++ C
Sbjct: 1253 FICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQ 1312
Query: 1042 QDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCI 1101
NPC +++ C GF C C PG++G C + D+C CKNGA C D N + C+
Sbjct: 1313 S--NPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCL 1370
Query: 1102 CPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKLVS 1161
C G++G CE + + C + C+N A C+ +N C+C PG+ G++CE S
Sbjct: 1371 CAAGFTGSHCELN-------INECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQS 1423
Query: 1162 VNF 1164
F
Sbjct: 1424 TGF 1426
Score = 169 bits (429), Expect = 1e-41
Identities = 77/206 (37%), Positives = 114/206 (55%), Gaps = 14/206 (6%)
Query: 907 CQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPC 966
C+ +D +C+P PC N+G C D V + C CP G+ GQ C+ I+ C S+PC
Sbjct: 1228 CETDID-----ECSPL---PCLNNGVCK-DLVGEFICECPSGYTGQRCEENINECSSSPC 1278
Query: 967 KHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPP 1026
+ G C +G G+ C C GF G +CE V++C+ N C NN+ C D + + C CPP
Sbjct: 1279 LNKGIC--VDGVA-GYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCPP 1335
Query: 1027 EYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCK 1086
+ G C + +D C PC++ + C F+C C G+ G HC+++ ++CQ N C+
Sbjct: 1336 GFLGTRCGKNVDECLSQ--PCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCR 1393
Query: 1087 NGAHCTDAVNGYTCICPEGYSGLFCE 1112
N A C D +N Y+C C G+SG CE
Sbjct: 1394 NQATCVDELNSYSCKCQPGFSGKRCE 1419
Score = 130 bits (327), Expect = 1e-29
Identities = 63/173 (36%), Positives = 94/173 (54%), Gaps = 9/173 (5%)
Query: 863 CDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTC-QGPVDVNILAKCNP 921
C+C + + E + C G D + + TC +G V ++ + N
Sbjct: 1255 CECPSGYTGQRCEENINECSSSPCLNKGICVDGVA----GYRCTCVKGFVGLHCETEVNE 1310
Query: 922 CLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDG 981
C SNPC N+ C D V + C CP GF G C + C+S PCK+G TC K+G +
Sbjct: 1311 CQSNPCLNNAVCE-DQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATC--KDGA-NS 1366
Query: 982 FWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCE 1034
F C+CA GF G +CE+N+++C+ N C N +TCVD +N+Y+C C P ++G+ CE
Sbjct: 1367 FRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
Score = 117 bits (294), Expect = 7e-26
Identities = 56/160 (35%), Positives = 79/160 (49%), Gaps = 9/160 (5%)
Query: 1001 DCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGF 1060
+C N C N+ TC Y CLCP YTG CE +D C+ PC ++ C F
Sbjct: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSP--LPCLNNGVCKDLVGEF 1253
Query: 1061 KCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLP 1120
C+C GY G+ C+ + ++C + C N C D V GY C C +G+ GL CE
Sbjct: 1254 ICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCE-------T 1306
Query: 1121 RTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKLV 1160
+ C + C N A C ++ +C+C PG+ G +C K V
Sbjct: 1307 EVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNV 1346
Score = 68.2 bits (165), Expect = 6e-11
Identities = 43/159 (27%), Positives = 68/159 (42%), Gaps = 19/159 (11%)
Query: 1335 PC-HKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSY 1393
PC +K +C G AG+ C C +G++G C+ N+ C N C++ +
Sbjct: 1277 PCLNKGICVDGV------AGYRCTCVKGFVGLHCETEVNE-CQSNPCLNNAVCEDQVGGF 1329
Query: 1394 SCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREIS- 1452
CKC G G C + D C + CK+G G C C++G+TG C+ I+
Sbjct: 1330 LCKCPPGFLGTRCGKNVD---ECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINE 1386
Query: 1453 CRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
C+ R+ A C +C+ G +G +C
Sbjct: 1387 CQSNPCRN-------QATCVDELNSYSCKCQPGFSGKRC 1418
Score = 66.6 bits (161), Expect = 2e-10
Identities = 30/85 (35%), Positives = 40/85 (47%), Gaps = 7/85 (8%)
Query: 1077 FDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQC 1136
F +C N C N C GY C+CP GY+GL CE C C N C
Sbjct: 1194 FHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETD-------IDECSPLPCLNNGVC 1246
Query: 1137 IVRINEPICQCLPGYQGEKCEKLVS 1161
+ E IC+C GY G++CE+ ++
Sbjct: 1247 KDLVGEFICECPSGYTGQRCEENIN 1271
Score = 65.1 bits (157), Expect = 5e-10
Identities = 33/117 (28%), Positives = 49/117 (41%), Gaps = 4/117 (3%)
Query: 1336 CHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSC 1395
C C + GF C+C G++G C + D CL C +G A S+ C
Sbjct: 1311 CQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNV-DECLSQPCKNGATCKDGANSFRC 1369
Query: 1396 KCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREIS 1452
C G G C+ N CQ+ C++ + L C+C G++G C+ E S
Sbjct: 1370 LCAAGFTGSHCELN---INECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQS 1423
Score = 57.4 bits (137), Expect = 1e-07
Identities = 35/122 (28%), Positives = 54/122 (44%), Gaps = 17/122 (13%)
Query: 1335 PCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTND----PCLGNKCVHGTCLPINA 1390
PCH GTCQ + G+ C C G+ G C+ ++ PCL N G C +
Sbjct: 1201 PCHNS----GTCQQLGR-GYVCLCPLGYTGLKCETDIDECSPLPCLNN----GVCKDLVG 1251
Query: 1391 FSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDRE 1450
+ C+C G+ G C+E N C + C + + G+ C C G+ G C+ E
Sbjct: 1252 -EFICECPSGYTGQRCEEN---INECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETE 1307
Query: 1451 IS 1452
++
Sbjct: 1308 VN 1309
Score = 56.2 bits (134), Expect = 2e-07
Identities = 38/118 (32%), Positives = 49/118 (41%), Gaps = 19/118 (16%)
Query: 919 CNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGE 978
C PC+N G C C+CP G+ G+ C+ PI CI PC +GG C
Sbjct: 3468 CRAVCRFPCQNGGICQRPNA----CSCPEGWMGRLCEEPI--CIL-PCLNGGRCVAP--- 3517
Query: 979 EDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEK 1036
+ C C G+ G C V C+ + C N CV C C +TG C K
Sbjct: 3518 ---YQCDCPPGWTGSRCHTAV--CQ-SPCLNGGKCV---RPNRCHCLSSWTGHNCSRK 3566
Score = 53.1 bits (126), Expect = 2e-06
Identities = 33/105 (31%), Positives = 46/105 (43%), Gaps = 17/105 (16%)
Query: 1007 CENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTP 1066
C+N C C CP + G LCEE + C + PC + +C+ ++CDC P
Sbjct: 3476 CQNGGICQ---RPNACSCPEGWMGRLCEEPI--C---ILPCLNGGRCVAP---YQCDCPP 3524
Query: 1067 GYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFC 1111
G+ G C CQ + C NG C V C C ++G C
Sbjct: 3525 GWTGSRCHTAV--CQ-SPCLNGGKC---VRPNRCHCLSSWTGHNC 3563
Score = 50.1 bits (118), Expect = 2e-05
Identities = 39/123 (31%), Positives = 50/123 (40%), Gaps = 25/123 (20%)
Query: 1331 PGCEPCHKKVCAHG-TCQPSSQAGFTCECQEGWMGPLCDQRTND-PCL-GNKCVHGTCLP 1387
P C + C +G CQ + C C EGWMG LC++ PCL G +CV
Sbjct: 3466 PICRAVCRFPCQNGGICQRPN----ACSCPEGWMGRLCEEPICILPCLNGGRCV------ 3515
Query: 1388 INAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSC 1447
Y C C G G C CQ+ GKC + C C S +TG +C
Sbjct: 3516 ---APYQCDCPPGWTGSRCHTA-----VCQSPCLNGGKC----VRPNRCHCLSSWTGHNC 3563
Query: 1448 DRE 1450
R+
Sbjct: 3564 SRK 3566
Score = 48.9 bits (115), Expect = 4e-05
Identities = 34/119 (28%), Positives = 53/119 (44%), Gaps = 24/119 (20%)
Query: 1375 CLGNKCVH-GTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKC-KHGKCRLSGLG 1432
C N C + GTC + Y C C G+ G+ C+ + D C + C +G C+ +G
Sbjct: 1197 CFFNPCHNSGTCQQLGR-GYVCLCPLGYTGLKCETDID---ECSPLPCLNNGVCK-DLVG 1251
Query: 1433 QPYCECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
+ CEC SGYTG C+ I+ C ++ +++ C G AG +C
Sbjct: 1252 EFICECPSGYTGQRCEENIN-----------------ECSSSPCLNKGICVDGVAGYRC 1293
Score = 47.0 bits (110), Expect = 1e-04
Identities = 26/76 (34%), Positives = 33/76 (43%), Gaps = 16/76 (21%)
Query: 1085 CKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPI 1144
C+NG C C CPEG+ G CE P +LP C NG +C+
Sbjct: 3476 CQNGGICQ---RPNACSCPEGWMGRLCE-EPICILP---------CLNGGRCVAPYQ--- 3519
Query: 1145 CQCLPGYQGEKCEKLV 1160
C C PG+ G +C V
Sbjct: 3520 CDCPPGWTGSRCHTAV 3535
Score = 35.4 bits (80), Expect = 0.43
Identities = 13/36 (36%), Positives = 24/36 (66%), Gaps = 1/36 (2%)
Query: 997 VNVDDCE-DNDCENNSTCVDGINNYTCLCPPEYTGE 1031
++VD+C +DC +++C++ +Y C C P YTG+
Sbjct: 1744 LDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGD 1779
Score = 33.5 bits (75), Expect = 1.6
Identities = 38/148 (25%), Positives = 48/148 (32%), Gaps = 35/148 (23%)
Query: 1032 LCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCK----- 1086
LC+E D C + C KC F+C C GY G+ + C K
Sbjct: 280 LCDEGKD-CCDRMGSC----KCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSP 334
Query: 1087 ------------NGAHCTDAVNGYTCICPEGY--SGLFCEF--SPPMVLPRTSPCDNFDC 1130
N + + C+C EGY SG CE P + P C
Sbjct: 335 GGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTC 394
Query: 1131 QN--GAQCIVR-------INEPICQCLP 1149
N A C VR + I CLP
Sbjct: 395 NNHFNAACGVRCHPGFDLVGSSIILCLP 422
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 181 bits (458), Expect = 6e-45
Identities = 135/435 (31%), Positives = 215/435 (49%), Gaps = 22/435 (5%)
Query: 23 VAPQACPAQCSCS-GSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHL 81
+A CP++C+CS S V+C G + +VP +P N L + +IT + ++ F + L
Sbjct: 26 LAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISAL 85
Query: 82 RVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQA 141
L++ +N++S I GAF++L L L L N LQ+ P LF G L L LS NQ+
Sbjct: 86 IALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQ 145
Query: 142 IPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKL 201
I F ++K LQL N + I DGAF L L L L N++T +S F H+ L
Sbjct: 146 IQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNL 205
Query: 202 RTFRLHSNNLY-----CDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFV 256
+ RL+ N L L L + Q+ ++GL + G H HN+ +R ++
Sbjct: 206 QVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSP--GLFH-NNHNL----QRLYL 258
Query: 257 CSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNL---PETITEIRLEQNTIK 313
+ H S + PS + P N + G L E+ + + E+ L N I
Sbjct: 259 SNNHISQLPPSI-FMQLPQL-----NRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHIS 312
Query: 314 VIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFS 373
+P FS ++L+ + LS NQIS ++P AF GL L L L+ N + +L ++F L +
Sbjct: 313 SLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLAN 372
Query: 374 LQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFI 433
LQ + L N++ L + F +++ L + L +N+L+ + G F L + + L NP+
Sbjct: 373 LQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWR 432
Query: 434 CDCHLKWLADYLHTN 448
CD + L ++L N
Sbjct: 433 CDSDILPLRNWLLLN 447
Score = 140 bits (353), Expect = 9e-33
Identities = 114/421 (27%), Positives = 193/421 (45%), Gaps = 21/421 (4%)
Query: 273 CPAACTCSN-NIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDL 331
CP+ CTCS + V+C G + +PT LP +++ I + F L + +
Sbjct: 31 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 90
Query: 332 SNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDA 391
N++S + P AF+ L SL L L NK+ LP LF+GL SL+ LLL++N++ ++
Sbjct: 91 EKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAH 150
Query: 392 FQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCH-----------LKW 440
F NL L L+ N L+ I G F L + ++L +N L+
Sbjct: 151 FSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRL 210
Query: 441 LADYLHTNPIET-SGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGD 499
+ L P+ T G L +IG + F + Q + ++ S+L
Sbjct: 211 YENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYL-SNNHISQLPPS 269
Query: 500 CFADLACPEKCRCEGTTV-DCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLP 558
F L + G ++ + S +P EL L +N + L +F L
Sbjct: 270 IFMQLPQLNRLTLFGNSLKELSLGIFGPMPN-----LRELWLYDNHISSLP-DNVFSNLR 323
Query: 559 QLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRI 618
QL+ + S N+I+ I GAF G + + E+ L +N L+++ +F+ L +L+ + L++NR+
Sbjct: 324 QLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRL 383
Query: 619 TCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEW 678
+ + F ++ + + L +NQ+ + G FD L L L L NP+ C+ + L W
Sbjct: 384 RQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNW 443
Query: 679 L 679
L
Sbjct: 444 L 444
Score = 110 bits (274), Expect = 1e-23
Identities = 106/391 (27%), Positives = 164/391 (41%), Gaps = 73/391 (18%)
Query: 506 CPEKCRCE-GTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEAT------------- 551
CP +C C + V+C+ ++ +P +P L++ N T L +
Sbjct: 31 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 90
Query: 552 ----------GIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKM 601
G F+ L LR ++ +NNK+ + G F+G + +LL+SN+L +Q
Sbjct: 91 EKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAH 150
Query: 602 FKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNL 661
F +LK L L N + + + +F L + L+L N +T ++P F L +L L L
Sbjct: 151 FSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRL 210
Query: 662 LANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSC 721
N R I G F + +Q++A+Q N
Sbjct: 211 YEN---------------RLTDIPMGT-------FDGLVNLQELALQ---------QNQI 239
Query: 722 SPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVP---KELS---- 774
LS + SN + LP I + +L N+ TL KELS
Sbjct: 240 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQL----NRLTLFGNSLKELSLGIF 295
Query: 775 ----NYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLL 830
N + L L D N IS+L + FSN+ QL LILS N++ I P F+GL LR L
Sbjct: 296 GPMPNLRELWLYD---NHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELREL 352
Query: 831 SLHGNDISVVPEGAFNDLSALSHLAIGANPL 861
SLH N + + F L+ L ++++ N L
Sbjct: 353 SLHTNALQDLDGNVFRMLANLQNISLQNNRL 383
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 181 bits (458), Expect = 6e-45
Identities = 135/435 (31%), Positives = 215/435 (49%), Gaps = 22/435 (5%)
Query: 23 VAPQACPAQCSCS-GSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHL 81
+A CP++C+CS S V+C G + +VP +P N L + +IT + ++ F + L
Sbjct: 20 LAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISAL 79
Query: 82 RVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQA 141
L++ +N++S I GAF++L L L L N LQ+ P LF G L L LS NQ+
Sbjct: 80 IALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQ 139
Query: 142 IPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKL 201
I F ++K LQL N + I DGAF L L L L N++T +S F H+ L
Sbjct: 140 IQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNL 199
Query: 202 RTFRLHSNNLY-----CDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFV 256
+ RL+ N L L L + Q+ ++GL + G H HN+ +R ++
Sbjct: 200 QVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSP--GLFH-NNHNL----QRLYL 252
Query: 257 CSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNL---PETITEIRLEQNTIK 313
+ H S + PS + P N + G L E+ + + E+ L N I
Sbjct: 253 SNNHISQLPPSI-FMQLPQL-----NRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHIS 306
Query: 314 VIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFS 373
+P FS ++L+ + LS NQIS ++P AF GL L L L+ N + +L ++F L +
Sbjct: 307 SLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLAN 366
Query: 374 LQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFI 433
LQ + L N++ L + F +++ L + L +N+L+ + G F L + + L NP+
Sbjct: 367 LQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWR 426
Query: 434 CDCHLKWLADYLHTN 448
CD + L ++L N
Sbjct: 427 CDSDILPLRNWLLLN 441
Score = 140 bits (353), Expect = 9e-33
Identities = 114/421 (27%), Positives = 193/421 (45%), Gaps = 21/421 (4%)
Query: 273 CPAACTCSN-NIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDL 331
CP+ CTCS + V+C G + +PT LP +++ I + F L + +
Sbjct: 25 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 84
Query: 332 SNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDA 391
N++S + P AF+ L SL L L NK+ LP LF+GL SL+ LLL++N++ ++
Sbjct: 85 EKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAH 144
Query: 392 FQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCH-----------LKW 440
F NL L L+ N L+ I G F L + ++L +N L+
Sbjct: 145 FSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRL 204
Query: 441 LADYLHTNPIET-SGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGD 499
+ L P+ T G L +IG + F + Q + ++ S+L
Sbjct: 205 YENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYL-SNNHISQLPPS 263
Query: 500 CFADLACPEKCRCEGTTV-DCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLP 558
F L + G ++ + S +P EL L +N + L +F L
Sbjct: 264 IFMQLPQLNRLTLFGNSLKELSLGIFGPMPN-----LRELWLYDNHISSLP-DNVFSNLR 317
Query: 559 QLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRI 618
QL+ + S N+I+ I GAF G + + E+ L +N L+++ +F+ L +L+ + L++NR+
Sbjct: 318 QLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRL 377
Query: 619 TCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEW 678
+ + F ++ + + L +NQ+ + G FD L L L L NP+ C+ + L W
Sbjct: 378 RQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNW 437
Query: 679 L 679
L
Sbjct: 438 L 438
Score = 110 bits (274), Expect = 1e-23
Identities = 106/391 (27%), Positives = 164/391 (41%), Gaps = 73/391 (18%)
Query: 506 CPEKCRCE-GTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEAT------------- 551
CP +C C + V+C+ ++ +P +P L++ N T L +
Sbjct: 25 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 84
Query: 552 ----------GIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKM 601
G F+ L LR ++ +NNK+ + G F+G + +LL+SN+L +Q
Sbjct: 85 EKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAH 144
Query: 602 FKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNL 661
F +LK L L N + + + +F L + L+L N +T ++P F L +L L L
Sbjct: 145 FSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRL 204
Query: 662 LANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSC 721
N R I G F + +Q++A+Q N
Sbjct: 205 YEN---------------RLTDIPMGT-------FDGLVNLQELALQ---------QNQI 233
Query: 722 SPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVP---KELS---- 774
LS + SN + LP I + +L N+ TL KELS
Sbjct: 234 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQL----NRLTLFGNSLKELSLGIF 289
Query: 775 ----NYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLL 830
N + L L D N IS+L + FSN+ QL LILS N++ I P F+GL LR L
Sbjct: 290 GPMPNLRELWLYD---NHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELREL 346
Query: 831 SLHGNDISVVPEGAFNDLSALSHLAIGANPL 861
SLH N + + F L+ L ++++ N L
Sbjct: 347 SLHTNALQDLDGNVFRMLANLQNISLQNNRL 377
>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
Length = 3144
Score = 178 bits (452), Expect = 3e-44
Identities = 89/278 (32%), Positives = 134/278 (48%), Gaps = 50/278 (17%)
Query: 920 NPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCH------ 973
N C NPCKN+ TC +D YRC C G+ GQ+C I+ C S+PC +GG CH
Sbjct: 773 NECKMNPCKNNSTC-TDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPG 831
Query: 974 --------LKEGE--------------------------EDGFWCICADGFEGENCEVNV 999
L G+ + CIC + FEG+NCE++V
Sbjct: 832 QFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDV 891
Query: 1000 DDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKG 1059
DC C++ C D +NN+ C+C P ++G LCE +++ C+ + PC+++ C+
Sbjct: 892 KDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSE--PCKNNGTCVDLTNR 949
Query: 1060 FKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVL 1119
F C+C P Y G C++D + C+ + C + +C +GY C+C GY+G+ CE +
Sbjct: 950 FFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEIN----- 1004
Query: 1120 PRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCE 1157
C + C + CI IN C C G+ G CE
Sbjct: 1005 --LDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCE 1040
Score = 175 bits (444), Expect = 3e-43
Identities = 103/333 (30%), Positives = 144/333 (43%), Gaps = 44/333 (13%)
Query: 863 CDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGP---VDVNILAKC 919
C+C W E E C G + T P + F C P +
Sbjct: 795 CECTSGWTGQNCSEEINECDSDPCMNGGLCHES---TIPGQ-FVCLCPPLYTGQFCHQRY 850
Query: 920 NPC--LSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEG 977
N C L NPC+N+ TC + C C F+G++C++ + C+ C+ G C E
Sbjct: 851 NLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDC---ED 907
Query: 978 EEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKL 1037
+ F CIC GF G CE+ +++C C+NN TCVD N + C C PEY G CE +
Sbjct: 908 MVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDV 967
Query: 1038 DFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNG 1097
+ C ++PC + C+ G+ C C PGY G +C+I+ D+C C + C D +N
Sbjct: 968 NKCK--ISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINH 1025
Query: 1098 YTCICPEGYSGLFCE------FSPPMVLPRTS------PCDNFDCQNGAQCIVRI----- 1140
YTC C G+ G CE S P + R + PC QC ++I
Sbjct: 1026 YTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCDADGTSTQCKIKINDCTS 1085
Query: 1141 ----NEPICQ---------CLPGYQGEKCEKLV 1160
NE CQ C GY G CEK +
Sbjct: 1086 IPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSI 1118
Score = 172 bits (437), Expect = 2e-42
Identities = 87/275 (31%), Positives = 123/275 (44%), Gaps = 44/275 (16%)
Query: 920 NPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEE 979
N C S PCKN+GTC D + + C C + G C++ ++ C +PC C +
Sbjct: 930 NECSSEPCKNNGTC-VDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRT--- 985
Query: 980 DGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDF 1039
DG+ C+CA G+ G NCE+N+D+C C ++ C+DGIN+YTC C + G CE +
Sbjct: 986 DGYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNAND 1045
Query: 1040 CAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYT 1099
C NPC H +C + C C C I +DC C N C + +G+T
Sbjct: 1046 CLS--NPCLH-GRCTELINEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFT 1102
Query: 1100 CICPEGYSGLFCE-------------------------------------FSPPMVLPRT 1122
CICP GY+G +CE FS
Sbjct: 1103 CICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEINI 1162
Query: 1123 SPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCE 1157
+ C + C +GA C IN +C+C PG+ G CE
Sbjct: 1163 NECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCE 1197
Score = 171 bits (433), Expect = 5e-42
Identities = 85/252 (33%), Positives = 135/252 (53%), Gaps = 26/252 (10%)
Query: 922 CLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEE-- 979
C S CKN GT ++ ++ C GFKG C++ I C S+PCK+G TC + G
Sbjct: 647 CKSASCKN-GTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFC 705
Query: 980 ---------DGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTG 1030
DGF C+C G+ G CE ++DDC N CE+NSTC D +Y C+C ++ G
Sbjct: 706 QCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEG 765
Query: 1031 ELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAH 1090
CE++ + C +NPC+++S C K ++C+CT G+ G++C + ++C + C NG
Sbjct: 766 NFCEQESNEC--KMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGL 823
Query: 1091 CTDAV--NGYTCICPEGYSGLFCEFSPPMVLPRTSPCD--NFDCQNGAQCIVRIN-EPIC 1145
C ++ + C+CP Y+G FC R + CD + C+N + C+ ++ C
Sbjct: 824 CHESTIPGQFVCLCPPLYTGQFCH-------QRYNLCDLLHNPCRNNSTCLALVDANQHC 876
Query: 1146 QCLPGYQGEKCE 1157
C ++G+ CE
Sbjct: 877 ICREEFEGKNCE 888
Score = 166 bits (420), Expect = 2e-40
Identities = 80/259 (30%), Positives = 124/259 (47%), Gaps = 17/259 (6%)
Query: 905 FTC---QGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHAC 961
F+C G V + + C+ N C+++ TC + Y+C C ++G C+ + C
Sbjct: 717 FSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLS-YQCVCLSDWEGNFCEQESNEC 775
Query: 962 ISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGI--NN 1019
NPCK+ TC + C C G+ G+NC +++C+ + C N C +
Sbjct: 776 KMNPCKNNSTC---TDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQ 832
Query: 1020 YTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCI-LTPKGFKCDCTPGYVGEHCDIDFD 1078
+ CLCPP YTG+ C ++ + C NPC+++S C+ L C C + G++C+ID
Sbjct: 833 FVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVK 892
Query: 1079 DCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIV 1138
DC C++ C D VN + CIC G+SG CE + C + C+N C+
Sbjct: 893 DCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEI-------EINECSSEPCKNNGTCVD 945
Query: 1139 RINEPICQCLPGYQGEKCE 1157
N C C P Y G CE
Sbjct: 946 LTNRFFCNCEPEYHGPFCE 964
Score = 166 bits (419), Expect = 2e-40
Identities = 104/351 (29%), Positives = 155/351 (44%), Gaps = 43/351 (12%)
Query: 811 NRLRCIPPRTFDGLKSLRLLSLHGNDISVVP---EGAFNDLSALSHLAIGANPLYCDCNM 867
N RCI F G L + N+ S P G DL+ N +C+C
Sbjct: 910 NNFRCICRPGFSG----SLCEIEINECSSEPCKNNGTCVDLT---------NRFFCNCEP 956
Query: 868 QWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQ-GPVDVNILAKCNPCLSNP 926
++ + + + + I+ C + + T C G +N + CLS P
Sbjct: 957 EYHGPFCELDVNKCKISPCLDE----ENCVYRTDGYNCLCAPGYTGINCEINLDECLSEP 1012
Query: 927 CKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCIC 986
C +DG C D ++ Y C C GF G C+ + C+SNPC HG L + + C C
Sbjct: 1013 CLHDGVC-IDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELI----NEYPCSC 1067
Query: 987 ADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQ-DLN 1045
C++ ++DC C N C + +TC+CP YTG CE+ +D CA+ +LN
Sbjct: 1068 DADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELN 1127
Query: 1046 P--CQHDSKCILTP-KGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCIC 1102
C + C+ P F C C PG+ G+ C+I+ ++C + C +GA C D +NGY C C
Sbjct: 1128 SVICLNGGICVDGPGHTFDCRCLPGFSGQFCEININECSSSPCLHGADCEDHINGYVCKC 1187
Query: 1103 PEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEP--ICQCLPGY 1151
G+SG CE + + C + C NEP C C PG+
Sbjct: 1188 QPGWSGHHCENELECI---PNSCVHELCME--------NEPGSTCLCTPGF 1227
Score = 129 bits (323), Expect = 3e-29
Identities = 98/348 (28%), Positives = 149/348 (42%), Gaps = 28/348 (8%)
Query: 1080 CQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVR 1139
C KC NG C ++ C C G+ G FC + P P + C GA CI
Sbjct: 2614 CSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHH--CSRGATCISL 2671
Query: 1140 INEPICQCLPGYQGEKCEKLVSVNF----INKESYLQIPSAKVRPQTNITLQIATDEDSG 1195
+ C C G G CE+ +S++ N+ S++ S VR +T+I LQ G
Sbjct: 2672 PHGYTCFCPLGTTGIYCEQALSISDPSFRSNELSWMSFASFHVRKKTHIQLQFQPLAADG 2731
Query: 1196 ILLYKGDK------DHIAVELYRGRVRASYDTGSHPA--SAIYSVETINDGNFHIVELLA 1247
IL Y D + + L V+ Y+ G + V TIN +HI++
Sbjct: 2732 ILFYAAQHLKAQSGDFLCISLVNSSVQLRYNLGDRTIILETLQKV-TINGSTWHIIKAGR 2790
Query: 1248 LDQSLSLSVDGGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGC 1307
+ L +DG N + +K S+L+ ++ Y+GG+ + V + A F GC
Sbjct: 2791 VGAEGYLDLDGINVTEKAS-TKMSSLDTNTDFYIGGVSSLNLVNPM--AIENEPVGFQGC 2847
Query: 1308 IRNLYINSELQDFQKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAG-----FTCECQEGW 1362
IR + IN++ + + G G C C + TC+ + F+C C W
Sbjct: 2848 IRQVIINNQELQLTEFGAKGGSNVG--DCDGTACGYNTCRNGGECTVNGTTFSCRCLPDW 2905
Query: 1363 MGPLCDQRTNDPCLGNKCVH-GTCLPINAFSYSCKCLEGHGGVLCDEE 1409
G C+Q + CL N C+H C+P +FSYSC C G G C+ +
Sbjct: 2906 AGNTCNQSVS--CLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCENK 2951
Score = 127 bits (318), Expect = 1e-28
Identities = 72/255 (28%), Positives = 113/255 (44%), Gaps = 34/255 (13%)
Query: 925 NPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPC--KHGGTCHLKEGEEDGF 982
N C+++ C D ++ RC+C + G+ C V + C+ N HG L
Sbjct: 573 NECQHEAVCK-DEINRPRCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLALSHN----- 626
Query: 983 WCICA--DGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFC 1040
C C+ +E CE++ +DC+ C+N +T + C P + G CE +D C
Sbjct: 627 -CNCSGLQRYERNICEIDTEDCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDEC 685
Query: 1041 AQDLNPCQHDSKCILTP--------------KGFKCDCTPGYVGEHCDIDFDDCQDNKCK 1086
A +PC++ + CI P GF C C PGYVG C+ D DDC N C+
Sbjct: 686 AS--HPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACE 743
Query: 1087 NGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQ 1146
+ + C D Y C+C + G FCE ++ C C+N + C C+
Sbjct: 744 HNSTCKDLHLSYQCVCLSDWEGNFCE-------QESNECKMNPCKNNSTCTDLYKSYRCE 796
Query: 1147 CLPGYQGEKCEKLVS 1161
C G+ G+ C + ++
Sbjct: 797 CTSGWTGQNCSEEIN 811
Score = 116 bits (290), Expect = 2e-25
Identities = 64/191 (33%), Positives = 87/191 (45%), Gaps = 26/191 (13%)
Query: 918 KCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACI-----SNPCKHGGTC 972
K N C S PC N+G C F C CP G+ G C+ I C S C +GG C
Sbjct: 1079 KINDCTSIPCMNEGFCQKSAHGF-TCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGIC 1137
Query: 973 HLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGEL 1032
+G F C C GF G+ CE+N+++C + C + + C D IN Y C C P ++G
Sbjct: 1138 --VDGPGHTFDCRCLPGFSGQFCEININECSSSPCLHGADCEDHINGYVCKCQPGWSGHH 1195
Query: 1033 CEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCT 1092
CE +L+ N C H+ C+ G C CTPG++ C G C
Sbjct: 1196 CENELECIP---NSCVHEL-CMENEPGSTCLCTPGFM--------------TCSIGLLCG 1237
Query: 1093 DAVNGYTCICP 1103
D + TC+ P
Sbjct: 1238 DEIRRITCLTP 1248
Score = 108 bits (269), Expect = 5e-23
Identities = 71/275 (25%), Positives = 117/275 (42%), Gaps = 23/275 (8%)
Query: 907 CQGPVDVNILAK---CNPCLSNP-CKNDGTCNSDPVD-FYRCTCPYGFKGQDCDVPIHAC 961
C + +N+ K C LS+ C G C S+ Y C C F G+ C + AC
Sbjct: 159 CPLGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDAC 217
Query: 962 ISNPCKHGGTCHLKEG--EEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINN 1019
PCK+ G+C K +E + C+C F G+NC + C+ + C + + N+
Sbjct: 218 SFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNS 277
Query: 1020 YTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDD 1079
+ C C +++G CE C L C + + +C G ++ + D +
Sbjct: 278 FICECDEQFSGPFCEVSAKPCVSLL--FWKRGICPNSSSAYTYECPKGSSSQNGETDVSE 335
Query: 1080 CQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVR 1139
C+NG C N CIC ++ L C+ + C++F +N A C
Sbjct: 336 FSLVPCQNGTDCIKISNDVMCICSPIFTDLLCK-------SIQTSCESFPLRNNATCKKC 388
Query: 1140 INEPICQCLPGYQGEKCE------KLVSVNFINKE 1168
+ C C+ G+ + CE KL+S+N +N+E
Sbjct: 389 EKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEE 423
Score = 106 bits (265), Expect = 2e-22
Identities = 73/274 (26%), Positives = 105/274 (38%), Gaps = 40/274 (14%)
Query: 907 CQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPC 966
CQG +D N C D T +DP D C P H C
Sbjct: 493 CQGVIDAYFFLAAN------CTEDATYVNDPED----------NNSSCWFP-HEGTKEIC 535
Query: 967 KHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPP 1026
+G +C L E + + +C + G N D ++N+C++ + C D IN C C
Sbjct: 536 ANGCSC-LSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRCSCSL 594
Query: 1027 EYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCK 1086
Y G LC +D+C + + H C+ C Y C+ID +DC+ CK
Sbjct: 595 SYIGRLCVVNVDYCLGNHSISVH-GLCLALSHNCNCSGLQRYERNICEIDTEDCKSASCK 653
Query: 1087 NGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQ 1146
NG T + C G+ G CE C + C+NGA CI + CQ
Sbjct: 654 NGTTSTHLRGYFFRKCVPGFKGTQCEID-------IDECASHPCKNGATCIDQPGNYFCQ 706
Query: 1147 CL--------------PGYQGEKCEKLVSVNFIN 1166
C+ PGY G +CE+ + +N
Sbjct: 707 CVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILN 740
Score = 99.8 bits (247), Expect = 2e-20
Identities = 97/383 (25%), Positives = 149/383 (38%), Gaps = 55/383 (14%)
Query: 1071 EHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDC 1130
E+C + + C + C+N C C CP YSG C+F + C+N C
Sbjct: 2332 ENCHVPW--CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQF---------ASCENNPC 2380
Query: 1131 QNGAQCIVRI-NEPICQCLPGYQGEKCEKLVSV-----------NFINKESYLQIPSAKV 1178
NGA C+ + + +C C G G C +++ + + +Y +I
Sbjct: 2381 GNGATCVPKSGTDIVCLCPYGRSGPLCTDAINITQPRFSGTDAFGYTSFLAYSRISDISF 2440
Query: 1179 RPQTNITLQIATDE---DSGILLYKGDKDH-------IAVELYRGRVRASYDTGSHPASA 1228
+ ++ Q+A + + ++ + G K H +AV L G V SY+ GS AS
Sbjct: 2441 HYEFHLKFQLANNHSALQNNLIFFTGQKGHGLNGDDFLAVGLLNGSVVYSYNLGSGIASI 2500
Query: 1229 IYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQSTLNFDSPLYVGGMPGKS 1288
++ G H V L Q L VD K I + LN S YVGG +
Sbjct: 2501 RSEPLNLSLG-VHTVHLGKFFQEGWLKVDDHKNKSIIAPGRLVGLNVFSQFYVGGYSEYT 2559
Query: 1289 NVASLRQAPGQNGTSFHGCIRNLYINSE-------LQDFQKVPMQTGILPGC--EPCHKK 1339
A +NG F GCI L + +E L + + P + C PC
Sbjct: 2560 PDLLPNGADFKNG--FQGCIFTLQVRTEKDGHFRGLGNPEGHPNAGRSVGQCHASPCSLM 2617
Query: 1340 VCAHGTCQPSSQAGFTCECQEGWMGPLCDQRT------NDPCLGNKCVHG-TCLPINAFS 1392
C +G S C C GW G C + +DP + C G TC+ +
Sbjct: 2618 KCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDP--PHHCSRGATCISL-PHG 2674
Query: 1393 YSCKCLEGHGGVLCDEEEDLFNP 1415
Y+C C G G+ C++ + +P
Sbjct: 2675 YTCFCPLGTTGIYCEQALSISDP 2697
Score = 73.2 bits (178), Expect = 2e-12
Identities = 91/368 (24%), Positives = 135/368 (36%), Gaps = 86/368 (23%)
Query: 1080 CQDNKCKNGAHC-----TDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGA 1134
CQ + C NG C + + + C CP ++G FCE + P
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAGLFFPS------------- 2149
Query: 1135 QCIVRINEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKV------RPQTNITLQI 1188
N SYL++P K I L I
Sbjct: 2150 ------------------------------FNGNSYLELPFLKFVLEKEHNRTVTIYLTI 2179
Query: 1189 ATDEDSGILLYKG----DKDHIAVELYRGRVRASYDTGSH----PASAIYSVET-----I 1235
T+ +G +LY K + + L GR Y G+ SA YS+ T I
Sbjct: 2180 KTNSLNGTILYSNGNNCGKQFLHLFLVEGRPSVKYGCGNSQNILTVSANYSINTNAFTPI 2239
Query: 1236 NDGNFHIVELLALDQSLSLSVDGGNP--KIITNLSKQSTLNFDSPLYVGGMPGKSNVASL 1293
V + + ++ DG P K T +S S F+S +++G +P +NV
Sbjct: 2240 TIRYTTPVGSPGVVCMIEMTADGKPPVQKKDTEISHASQAYFES-MFLGHIP--ANVQIH 2296
Query: 1294 RQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILPGCEPCHKKVCAHGTCQP----- 1348
++A G F GCI +L +N++ + F + G E CH CAH C+
Sbjct: 2297 KKAGPVYG--FRGCILDLQVNNK-EFFIIDEARHG--KNIENCHVPWCAHHLCRNNGTCI 2351
Query: 1349 SSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHG-TCLPINAFSYSCKCLEGHGGVLCD 1407
S CEC + G LC + C N C +G TC+P + C C G G LC
Sbjct: 2352 SDNENLFCECPRLYSGKLCQFAS---CENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCT 2408
Query: 1408 EEEDLFNP 1415
+ ++ P
Sbjct: 2409 DAINITQP 2416
Score = 70.9 bits (172), Expect = 9e-12
Identities = 77/317 (24%), Positives = 112/317 (35%), Gaps = 79/317 (24%)
Query: 921 PCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEED 980
PC+S G C + Y CP G Q+ + + PC++G C +K +
Sbjct: 297 PCVSLLFWKRGICPNSS-SAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDC-IKISND- 353
Query: 981 GFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFC 1040
CIC+ F C+ CE NN+TC +Y C C +T + CE+ +D C
Sbjct: 354 -VMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHC 412
Query: 1041 AQDLNPCQHDSKCILTPKGFKCDCTPG-------------YVGEH---CDIDFDD-CQD- 1082
C ++ C FK C PG + +H C + F CQD
Sbjct: 413 KLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDK 472
Query: 1083 ------------------NKCKN--------GAHCTDAV--------NGYTC-------- 1100
KC+ A+CT+ N +C
Sbjct: 473 GPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTK 532
Query: 1101 -ICPEGYSGL------------FCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQC 1147
IC G S L F ++ M L T+ +CQ+ A C IN P C C
Sbjct: 533 EICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRCSC 592
Query: 1148 LPGYQGEKCEKLVSVNF 1164
Y G C +V+V++
Sbjct: 593 SLSYIGRLC--VVNVDY 607
Score = 70.1 bits (170), Expect = 2e-11
Identities = 35/100 (35%), Positives = 50/100 (50%), Gaps = 4/100 (4%)
Query: 1353 GFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDL 1412
GF+C C G++G C+Q +D C+ N C H + SY C CL G C++E
Sbjct: 716 GFSCLCNPGYVGIRCEQDIDD-CILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQES-- 772
Query: 1413 FNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREIS 1452
N C+ CK+ CEC+SG+TG +C EI+
Sbjct: 773 -NECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEIN 811
Score = 67.0 bits (162), Expect = 1e-10
Identities = 42/120 (35%), Positives = 54/120 (45%), Gaps = 14/120 (11%)
Query: 1334 EPC-HKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFS 1392
EPC H VC G +TC+C+ G+ G C+ ND CL N C+HG C +
Sbjct: 1011 EPCLHDGVCIDGINH------YTCDCKSGFFGTHCETNAND-CLSNPCLHGRCTEL-INE 1062
Query: 1393 YSCKCLEGHGGVLCDEEEDLFNPCQAIKC-KHGKCRLSGLGQPYCECSSGYTGDSCDREI 1451
Y C C C + N C +I C G C+ S G C C GYTG C++ I
Sbjct: 1063 YPCSCDADGTSTQCKIK---INDCTSIPCMNEGFCQKSAHGFT-CICPRGYTGAYCEKSI 1118
Score = 64.7 bits (156), Expect = 7e-10
Identities = 35/115 (30%), Positives = 56/115 (48%), Gaps = 9/115 (7%)
Query: 1344 GTCQPSSQAGFTCECQEGWMGPLCDQRTN---DPCLGNK-CVHG-TCLPINAFSYSCKCL 1398
G CQ S+ GFTC C G+ G C++ + +P L + C++G C+ ++ C+CL
Sbjct: 1092 GFCQKSAH-GFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCL 1150
Query: 1399 EGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREISC 1453
G G C+ N C + C HG + C+C G++G C+ E+ C
Sbjct: 1151 PGFSGQFCEIN---INECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCENELEC 1202
Score = 60.5 bits (145), Expect = 1e-08
Identities = 36/116 (31%), Positives = 48/116 (41%), Gaps = 6/116 (5%)
Query: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSY 1393
+ C C H + + C C W G C+Q +N+ C N C + + SY
Sbjct: 735 DDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNE-CKMNPCKNNSTCTDLYKSY 793
Query: 1394 SCKCLEGHGGVLCDEEEDLFNPCQAIKCKH-GKCRLSGL-GQPYCECSSGYTGDSC 1447
C+C G G C EE N C + C + G C S + GQ C C YTG C
Sbjct: 794 RCECTSGWTGQNCSEE---INECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFC 846
Score = 58.5 bits (140), Expect = 5e-08
Identities = 36/120 (30%), Positives = 53/120 (44%), Gaps = 19/120 (15%)
Query: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTN----DPCLGNK-CVHGTCLPI 1388
EPC +GTC + F C C+ + GP C+ N PCL + CV+ T
Sbjct: 935 EPCKN----NGTCVDLTNR-FFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTD--- 986
Query: 1389 NAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCD 1448
Y+C C G+ G+ C+ D C + C H + G+ C+C SG+ G C+
Sbjct: 987 ---GYNCLCAPGYTGINCEINLD---ECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCE 1040
Score = 57.4 bits (137), Expect = 1e-07
Identities = 55/222 (24%), Positives = 86/222 (38%), Gaps = 29/222 (13%)
Query: 1286 GKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILPGCEPCHKKVCAHGT 1345
G+ V ++ G + S HG L N Q+ + E C C +GT
Sbjct: 598 GRLCVVNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNICEID-TEDCKSASCKNGT 656
Query: 1346 CQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHG-TCL--PINAF----------- 1391
+ F +C G+ G C+ D C + C +G TC+ P N F
Sbjct: 657 TSTHLRGYFFRKCVPGFKGTQCEIDI-DECASHPCKNGATCIDQPGNYFCQCVPPFKVVD 715
Query: 1392 SYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGK-CRLSGLGQPYCECSSGYTGDSCDRE 1450
+SC C G+ G+ C+++ D C C+H C+ L C C S + G+ C++E
Sbjct: 716 GFSCLCNPGYVGIRCEQDID---DCILNACEHNSTCKDLHLSY-QCVCLSDWEGNFCEQE 771
Query: 1451 IS-CRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
+ C+ ++ + C K R EC G G C
Sbjct: 772 SNECKMNPCKN-------NSTCTDLYKSYRCECTSGWTGQNC 806
Score = 53.1 bits (126), Expect = 2e-06
Identities = 27/83 (32%), Positives = 39/83 (46%), Gaps = 9/83 (10%)
Query: 998 NVDDCED-----NDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSK 1052
NV DC+ N C N C ++C C P++ G C + + C +L C H S
Sbjct: 2870 NVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS-CLNNL--CLHQSL 2926
Query: 1053 CILTPK-GFKCDCTPGYVGEHCD 1074
CI + C CT G+VG +C+
Sbjct: 2927 CIPDQSFSYSCLCTLGWVGRYCE 2949
Score = 52.8 bits (125), Expect = 3e-06
Identities = 27/74 (36%), Positives = 39/74 (52%), Gaps = 5/74 (6%)
Query: 922 CLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDG 981
C + C+N+GTC SD + + C CP + G+ C +C +NPC +G TC K G +
Sbjct: 2339 CAHHLCRNNGTCISDNENLF-CECPRLYSGKLCQFA--SCENNPCGNGATCVPKSGTD-- 2393
Query: 982 FWCICADGFEGENC 995
C+C G G C
Sbjct: 2394 IVCLCPYGRSGPLC 2407
Score = 52.8 bits (125), Expect = 3e-06
Identities = 27/82 (32%), Positives = 39/82 (47%), Gaps = 8/82 (9%)
Query: 961 CISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCED-----NDCENNSTCVD 1015
C C +GGTC ++ G +C C G++G C V C+ + C +TC+
Sbjct: 2614 CSLMKCGNGGTC-IESGTS--VYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCIS 2670
Query: 1016 GINNYTCLCPPEYTGELCEEKL 1037
+ YTC CP TG CE+ L
Sbjct: 2671 LPHGYTCFCPLGTTGIYCEQAL 2692
Score = 52.4 bits (124), Expect = 3e-06
Identities = 34/98 (34%), Positives = 46/98 (46%), Gaps = 11/98 (11%)
Query: 947 YGFKGQ----DCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDC 1002
+G KG DCD AC N C++GG C + F C C + G C +V C
Sbjct: 2863 FGAKGGSNVGDCDGT--ACGYNTCRNGGECTVNGTT---FSCRCLPDWAGNTCNQSVS-C 2916
Query: 1003 EDNDCENNSTCV-DGINNYTCLCPPEYTGELCEEKLDF 1039
+N C + S C+ D +Y+CLC + G CE K F
Sbjct: 2917 LNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCENKTSF 2954
Score = 52.4 bits (124), Expect = 3e-06
Identities = 64/278 (23%), Positives = 116/278 (41%), Gaps = 45/278 (16%)
Query: 1074 DIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNG 1133
D D C N C+NG CT ++C C ++G C ++ C N C +
Sbjct: 2873 DCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCN--------QSVSCLNNLCLHQ 2924
Query: 1134 AQCIV-RINEPICQCLPGYQGEKCEKLVSVNFIN--KESYLQI--PSAKVR--PQTNITL 1186
+ CI + C C G+ G CE S + SY++ P+ ++R T I+L
Sbjct: 2925 SLCIPDQSFSYSCLCTLGWVGRYCENKTSFSTAKFMGNSYIKYIDPNYRMRNLQFTTISL 2984
Query: 1187 QIATDEDSGILLYKG-----DKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNF- 1240
+T + G++++ G + D +A+ L+ ++ + + G I + N+G F
Sbjct: 2985 NFSTTKTEGLIVWMGIAQNEENDFLAIGLHNQTLKIAVNLGER----ISVPMSYNNGTFC 3040
Query: 1241 -----HIVEL-------LALDQSLSLSVDGGNPKIITNLSKQSTLNFDSPLYVGGMPGKS 1288
H+V + ++ SL LS D I LN+D Y+GG
Sbjct: 3041 CNKWHHVVVIQNQTLIKAYINNSLILSED------IDPHKNFVALNYDGICYLGGFEYGR 3094
Query: 1289 NVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQ 1326
V + Q + T+F G I+++ E ++ + + ++
Sbjct: 3095 KVNIVTQEIFK--TNFVGKIKDVVFFQEPKNIELIKLE 3130
Score = 50.8 bits (120), Expect = 1e-05
Identities = 22/82 (26%), Positives = 35/82 (42%), Gaps = 3/82 (3%)
Query: 996 EVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNP---CQHDSK 1052
+ + C C N TC++ + C C + G C E + C + +P C +
Sbjct: 2608 QCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGAT 2667
Query: 1053 CILTPKGFKCDCTPGYVGEHCD 1074
CI P G+ C C G G +C+
Sbjct: 2668 CISLPHGYTCFCPLGTTGIYCE 2689
Score = 50.4 bits (119), Expect = 1e-05
Identities = 37/157 (23%), Positives = 60/157 (38%), Gaps = 12/157 (7%)
Query: 1336 CHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSC 1395
C VC HG C + F CEC E + GP C+ PC+ P ++ +Y+
Sbjct: 260 CQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAK-PCVSLLFWKRGICPNSSSAYTY 318
Query: 1396 KCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDR-EISCR 1454
+C +G + + F+ + C++G + C CS +T C + SC
Sbjct: 319 ECPKGSSSQNGETDVSEFS---LVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCE 375
Query: 1455 GERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
+R+ A C+ +K C G C
Sbjct: 376 SFPLRN-------NATCKKCEKDYPCSCISGFTEKNC 405
Score = 50.4 bits (119), Expect = 1e-05
Identities = 26/78 (33%), Positives = 34/78 (43%), Gaps = 7/78 (8%)
Query: 1336 CHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSC 1395
C C HG G+ C+CQ GW G C+ C+ N CVH C+ N +C
Sbjct: 1165 CSSSPCLHGADCEDHINGYVCKCQPGWSGHHCENELE--CIPNSCVHELCME-NEPGSTC 1221
Query: 1396 KCLEGHG----GVLCDEE 1409
C G G+LC +E
Sbjct: 1222 LCTPGFMTCSIGLLCGDE 1239
Score = 50.1 bits (118), Expect = 2e-05
Identities = 35/119 (29%), Positives = 55/119 (46%), Gaps = 17/119 (14%)
Query: 1337 HKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKC--VHGTCLPINAFSYS 1394
H+ VC +P C C ++G LC D CLGN VHG CL A S++
Sbjct: 577 HEAVCKDEINRPR------CSCSLSYIGRLCVVNV-DYCLGNHSISVHGLCL---ALSHN 626
Query: 1395 CKC--LEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREI 1451
C C L+ + +C+ + + C++ CK+G G + +C G+ G C+ +I
Sbjct: 627 CNCSGLQRYERNICEIDTE---DCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDI 682
Score = 49.3 bits (116), Expect = 3e-05
Identities = 32/121 (26%), Positives = 51/121 (42%), Gaps = 6/121 (4%)
Query: 1333 CEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCV-HGTCLPINAF 1391
C+ H + TC A C C+E + G C+ D CL C +G C +
Sbjct: 853 CDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKD-CLFLSCQDYGDCEDM-VN 910
Query: 1392 SYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREI 1451
++ C C G G LC+ E N C + CK+ + + +C C Y G C+ ++
Sbjct: 911 NFRCICRPGFSGSLCEIE---INECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDV 967
Query: 1452 S 1452
+
Sbjct: 968 N 968
Score = 48.1 bits (113), Expect = 6e-05
Identities = 41/132 (31%), Positives = 55/132 (41%), Gaps = 20/132 (15%)
Query: 1336 CHKKVCAHG-TCQPSSQAG-FTCECQEGWMGPLCDQRTN------DPCLGNKCVHGTCLP 1387
C C +G C S+ G F C C + G C QR N +PC N TCL
Sbjct: 813 CDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNN----STCLA 868
Query: 1388 INAFSYSCKCLEGHGGVLC--DEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGD 1445
+ + C C E G C D ++ LF CQ +G C + C C G++G
Sbjct: 869 LVDANQHCICREEFEGKNCEIDVKDCLFLSCQ----DYGDCE-DMVNNFRCICRPGFSGS 923
Query: 1446 SCDREIS-CRGE 1456
C+ EI+ C E
Sbjct: 924 LCEIEINECSSE 935
Score = 45.4 bits (106), Expect = 4e-04
Identities = 30/112 (26%), Positives = 45/112 (40%), Gaps = 11/112 (9%)
Query: 1343 HGTCQPSSQAG-FTCECQEGWMGPLCDQRTNDPCLGNKCVH-GTCLPI----NAFSYSCK 1396
HG C + + ++C CQ + G C + D C C + G+C+ + +Y C
Sbjct: 186 HGKCLSEAWSKTYSCHCQPPFSGKYCQEL--DACSFKPCKNNGSCINKRENWDEQAYECV 243
Query: 1397 CLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCD 1448
C G C E + CQ C HG C CEC ++G C+
Sbjct: 244 CHPPFTGKNCSE---IIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCE 292
Score = 43.5 bits (101), Expect = 0.002
Identities = 26/82 (31%), Positives = 31/82 (37%), Gaps = 9/82 (10%)
Query: 920 NPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHAC-----ISNPCKHGGTCHL 974
+PC C N GTC Y C C G+KG C + C + C G TC
Sbjct: 2612 SPCSLMKCGNGGTCIESGTSVY-CNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATC-- 2668
Query: 975 KEGEEDGFWCICADGFEGENCE 996
G+ C C G G CE
Sbjct: 2669 -ISLPHGYTCFCPLGTTGIYCE 2689
Score = 37.4 bits (85), Expect = 0.11
Identities = 59/255 (23%), Positives = 101/255 (39%), Gaps = 57/255 (22%)
Query: 1168 ESYLQIPSAKVRPQTNITLQIATDEDSGILLY-KGDK---DHIAVELY--RGRVRAS-YD 1220
+SYL+ + + PQ NI+L+ T G+LLY K D D ++L+ G ++ Y
Sbjct: 1891 DSYLEFQNVALNPQNNISLEFQTFSSYGLLLYVKQDSNLVDGFFIQLFIENGTLKYHFYC 1950
Query: 1221 TGSHPASAIYSVETINDGN-FHIVELLALDQ-SLSLSVDGGNPKIITNLSKQ--STLNFD 1276
G +I + +++G + ++ LD + L++ G N +I +++ L
Sbjct: 1951 PGEAKFKSINTTVRVDNGQKYTLLIRQELDPCNAELTILGRNTQICESINHVLGKPLPKS 2010
Query: 1277 SPLYVGGMPGKSNVASLRQAPGQNGTSFHGCI-----------------RNLYINS-ELQ 1318
+++GG P + P +N F GCI +N +IN+ Q
Sbjct: 2011 GSVFIGGFPDLHGKIQM-PVPVKN---FTGCIEVIEINNWRSFIPSKAVKNYHINNCRSQ 2066
Query: 1319 DFQKVP----------------MQTGILPGCEP---CHKKVCAHG-TCQP----SSQAGF 1354
F P M T + P C + VC +G TC S F
Sbjct: 2067 GFMLSPTASFVDASDVTQGVDTMWTSVSPSVAAPSVCQQDVCHNGGTCHAIFLSSGIVSF 2126
Query: 1355 TCECQEGWMGPLCDQ 1369
C+C + G C++
Sbjct: 2127 QCDCPLHFTGRFCEK 2141
Score = 34.3 bits (77), Expect = 0.95
Identities = 14/39 (35%), Positives = 20/39 (51%), Gaps = 5/39 (12%)
Query: 1002 CEDNDCENNSTC-----VDGINNYTCLCPPEYTGELCEE 1035
C+ + C N TC GI ++ C CP +TG CE+
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEK 2141
Score = 33.9 bits (76), Expect = 1.2
Identities = 12/39 (30%), Positives = 20/39 (51%)
Query: 1414 NPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREIS 1452
+PC +KC +G + YC C++G+ G C +S
Sbjct: 2612 SPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVS 2650
Score = 31.6 bits (70), Expect = 6.2
Identities = 13/38 (34%), Positives = 20/38 (52%), Gaps = 4/38 (10%)
Query: 922 CLSNPCKNDGTCN----SDPVDFYRCTCPYGFKGQDCD 955
C + C N GTC+ S + ++C CP F G+ C+
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCE 2140
>gi|122937283 6720455I24Rik homolog [Homo sapiens]
Length = 1413
Score = 176 bits (446), Expect = 2e-43
Identities = 151/575 (26%), Positives = 209/575 (36%), Gaps = 104/575 (18%)
Query: 922 CLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIH----ACISNPCKHGGTCHLKEG 977
C +PC N G+C D V Y C C FKG C+ H AC+S PC +GGTC
Sbjct: 391 CSPDPCLNGGSC-VDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTC---VD 446
Query: 978 EEDGFWCICADGFEGENCEVNV-DDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEK 1036
+ G+ C C +GF G +C V DDCE C N C+ G N C CP + G LCE +
Sbjct: 447 ADQGYVCECPEGFMGLDCRERVPDDCE---CRNGGRCL-GANTTLCQCPLGFFGLLCEFE 502
Query: 1037 LD--------------FCAQ-----------------------DLNPCQHDSKCILTPKG 1059
+ +C + D +PC + C
Sbjct: 503 ITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHDDS 562
Query: 1060 FKCDCTPGYVGEHCDIDFDD-CQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMV 1118
+ C+C G+ G+HC+ C C+NG C +A Y C CP ++G CE P
Sbjct: 563 YTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKP-- 620
Query: 1119 LPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKV 1178
C + C NG C I + C C PG+ G CE S F S V
Sbjct: 621 ----DSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCF---------RSPCV 667
Query: 1179 RPQTNITLQIATDEDSGILLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDG 1238
T D D+ H R +A D G P ++ N
Sbjct: 668 NGGT------CEDRDTDFFC------HCQAGYMGRRCQAEVDCGP-PEEVKHATLRFNGT 714
Query: 1239 NFHIVELLALDQSLSLSVDGGNPKIITNLSKQSTLNFDSPLYVGGMPGKS-NVASLRQAP 1297
V L A D+ SLS S + P V P + + R P
Sbjct: 715 RLGAVALYACDRGYSLSA-------------PSRIRVCQPHGVWSEPPQCLEIDECRSQP 761
Query: 1298 GQNGTSFHGCIRN-LYINSELQDFQKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTC 1356
+G S + L + S + ++ + C C +G + + C
Sbjct: 762 CLHGGSCQDRVAGYLCLCSTGYEGAHCELER------DECRAHPCRNGGSCRNLPGAYVC 815
Query: 1357 ECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPC 1416
C G++G C+ D C + C HG +Y C C E G C+ D PC
Sbjct: 816 RCPAGFVGVHCETEV-DACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCETVSD---PC 871
Query: 1417 QAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREI 1451
+ C L+ G C C GYTG+ C +E+
Sbjct: 872 FSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAKEL 906
Score = 175 bits (444), Expect = 3e-43
Identities = 101/313 (32%), Positives = 139/313 (44%), Gaps = 52/313 (16%)
Query: 886 CAGPGEMADKLLLTTPSKKFTC-QGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCT 944
C G+ D + PS +C G N C S PC+N GTC + ++ +RC
Sbjct: 278 CLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTC-THGINSFRCQ 336
Query: 945 CPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCED 1004
CP GF G C+ C + C+HGG C ++ G C+C G+ G CE++VDDC
Sbjct: 337 CPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSA---VCVCQAGYTGAACEMDVDDCSP 393
Query: 1005 NDCENNSTCVDGINNYTCLCPPEYTGELCE----EKLDFCAQDLNPCQHDSKCILTPKGF 1060
+ C N +CVD + NYTCLC + G CE D C PC + C+ +G+
Sbjct: 394 DPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLS--APCHNGGTCVDADQGY 451
Query: 1061 KCDCTPGYVGEHC-DIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMV- 1118
C+C G++G C + DDC+ C+NG C A N C CP G+ GL CEF +
Sbjct: 452 VCECPEGFMGLDCRERVPDDCE---CRNGGRCLGA-NTTLCQCPLGFFGLLCEFEITAMP 507
Query: 1119 ---------------------------------LPRTSPCDNFDCQNGAQCIVRINEPIC 1145
LP SPCD+ C NG C + C
Sbjct: 508 CNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLP--SPCDSDPCFNGGSCDAHDDSYTC 565
Query: 1146 QCLPGYQGEKCEK 1158
+C G+ G+ CEK
Sbjct: 566 ECPRGFHGKHCEK 578
Score = 156 bits (394), Expect = 2e-37
Identities = 84/244 (34%), Positives = 114/244 (46%), Gaps = 23/244 (9%)
Query: 922 CLS-NPCKNDGTCNSDPVD---FYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEG 977
CL+ PC N G C D V Y C+C GF G+ C + ++ C S PC++GGTC
Sbjct: 272 CLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTC---TH 328
Query: 978 EEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKL 1037
+ F C C GF G CE C+ +C++ C + C+C YTG CE +
Sbjct: 329 GINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDV 388
Query: 1038 DFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDF----DDCQDNKCKNGAHCTD 1093
D C+ D PC + C+ + C C + G C+ D C C NG C D
Sbjct: 389 DDCSPD--PCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVD 446
Query: 1094 AVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQG 1153
A GY C CPEG+ GL C P D+ +C+NG +C+ N +CQC G+ G
Sbjct: 447 ADQGYVCECPEGFMGLDCRERVP---------DDCECRNGGRCL-GANTTLCQCPLGFFG 496
Query: 1154 EKCE 1157
CE
Sbjct: 497 LLCE 500
Score = 150 bits (378), Expect = 1e-35
Identities = 72/210 (34%), Positives = 97/210 (46%), Gaps = 9/210 (4%)
Query: 954 CDVPIHACIS-NPCKHGGTC--HLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENN 1010
C C++ PC +GG C G + C C GF G C ++V++C C+N
Sbjct: 265 CGHTTSVCLALRPCLNGGKCIDDCVTGNPS-YTCSCLSGFTGRRCHLDVNECASQPCQNG 323
Query: 1011 STCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVG 1070
TC GIN++ C CP + G CE C D CQH +C + C C GY G
Sbjct: 324 GTCTHGINSFRCQCPAGFGGPTCETAQSPC--DTKECQHGGQCQVENGSAVCVCQAGYTG 381
Query: 1071 EHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDC 1130
C++D DDC + C NG C D V YTC+C E + GL CE P C + C
Sbjct: 382 AACEMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDH---PVPDACLSAPC 438
Query: 1131 QNGAQCIVRINEPICQCLPGYQGEKCEKLV 1160
NG C+ +C+C G+ G C + V
Sbjct: 439 HNGGTCVDADQGYVCECPEGFMGLDCRERV 468
Score = 149 bits (376), Expect = 2e-35
Identities = 77/260 (29%), Positives = 115/260 (44%), Gaps = 29/260 (11%)
Query: 916 LAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLK 975
+ K + C S PC N GTC + Y+C CP GF G+ C++ C +PC +GGTC
Sbjct: 617 IGKPDSCASGPCHNGGTC-FHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTC--- 672
Query: 976 EGEEDGFWCICADGFEGENCEVNVDDCEDNDCEN-----NSTCVDGINNYTC-------- 1022
E + F+C C G+ G C+ VD + ++ N T + + Y C
Sbjct: 673 EDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSA 732
Query: 1023 -----LCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDF 1077
+C P + L+ PC H C G+ C C+ GY G HC+++
Sbjct: 733 PSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELER 792
Query: 1078 DDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCI 1137
D+C+ + C+NG C + Y C CP G+ G+ CE CD+ CQ+G +C
Sbjct: 793 DECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCE-------TEVDACDSSPCQHGGRCE 845
Query: 1138 VRINEPICQCLPGYQGEKCE 1157
+C C + G CE
Sbjct: 846 SGGGAYLCVCPESFFGYHCE 865
Score = 139 bits (349), Expect = 3e-32
Identities = 74/263 (28%), Positives = 105/263 (39%), Gaps = 41/263 (15%)
Query: 920 NPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHG-----GT--- 971
+PC +PC N GTC DF+ C C G+ G+ C + KH GT
Sbjct: 659 SPCFRSPCVNGGTCEDRDTDFF-CHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLG 717
Query: 972 ----------------CHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVD 1015
++ + G W E C + +D+C C + +C D
Sbjct: 718 AVALYACDRGYSLSAPSRIRVCQPHGVWS------EPPQC-LEIDECRSQPCLHGGSCQD 770
Query: 1016 GINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDI 1075
+ Y CLC Y G CE + D C +PC++ C P + C C G+VG HC+
Sbjct: 771 RVAGYLCLCSTGYEGAHCELERDECRA--HPCRNGGSCRNLPGAYVCRCPAGFVGVHCET 828
Query: 1076 DFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQ 1135
+ D C + C++G C Y C+CPE + G CE + PC + C
Sbjct: 829 EVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCETV-------SDPCFSSPCGGRGY 881
Query: 1136 CIVRINEPICQCLPGYQGEKCEK 1158
C+ C C GY GE C K
Sbjct: 882 CLASNGSHSCTCKVGYTGEDCAK 904
Score = 138 bits (347), Expect = 5e-32
Identities = 81/266 (30%), Positives = 113/266 (42%), Gaps = 42/266 (15%)
Query: 917 AKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDV-PIHACISNPCKHGGTCHLK 975
A+ + C S PC+N GTC + Y C+CPY F G+ C++ +C S PC +GGTC
Sbjct: 579 ARPHLCSSGPCRNGGTCKEAGGE-YHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHY 637
Query: 976 EGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEE 1035
G+ + C C GF G +CE+ C + C N TC D ++ C C Y G C+
Sbjct: 638 IGK---YKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQA 694
Query: 1036 KLDFCAQDLNPCQHDSKCILTPKG--------FKCD-------------CTPGYVGE--- 1071
++ D P + L G + CD C P V
Sbjct: 695 EV-----DCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPP 749
Query: 1072 HCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQ 1131
C ++ D+C+ C +G C D V GY C+C GY G CE C C+
Sbjct: 750 QC-LEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCEL-------ERDECRAHPCR 801
Query: 1132 NGAQCIVRINEPICQCLPGYQGEKCE 1157
NG C +C+C G+ G CE
Sbjct: 802 NGGSCRNLPGAYVCRCPAGFVGVHCE 827
Score = 114 bits (286), Expect = 6e-25
Identities = 59/179 (32%), Positives = 86/179 (48%), Gaps = 9/179 (5%)
Query: 898 LTTPSKKFTCQGPVDVNILAKC---NPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDC 954
L+ PS+ CQ + +C + C S PC + G+C D V Y C C G++G C
Sbjct: 730 LSAPSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQ-DRVAGYLCLCSTGYEGAHC 788
Query: 955 DVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCV 1014
++ C ++PC++GG+C G + C C GF G +CE VD C+ + C++ C
Sbjct: 789 ELERDECRAHPCRNGGSCRNLPG---AYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCE 845
Query: 1015 DGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHC 1073
G Y C+CP + G CE D C +PC C+ + C C GY GE C
Sbjct: 846 SGGGAYLCVCPESFFGYHCETVSDPCFS--SPCGGRGYCLASNGSHSCTCKVGYTGEDC 902
Score = 63.5 bits (153), Expect = 1e-09
Identities = 44/164 (26%), Positives = 61/164 (37%), Gaps = 14/164 (8%)
Query: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSY 1393
+ C + C HG AG+ C C G+ G C+ D C + C +G +Y
Sbjct: 755 DECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELE-RDECRAHPCRNGGSCRNLPGAY 813
Query: 1394 SCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREISC 1453
C+C G GV C+ E D C + C+HG SG G C C + G C
Sbjct: 814 VCRCPAGFVGVHCETEVD---ACDSSPCQHGGRCESGGGAYLCVCPESFFGYHC------ 864
Query: 1454 RGERIRD--YYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPL 1495
E + D + G C + C+ G G C L
Sbjct: 865 --ETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAKEL 906
Score = 60.1 bits (144), Expect = 2e-08
Identities = 47/184 (25%), Positives = 74/184 (40%), Gaps = 15/184 (8%)
Query: 1331 PGCE----PCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCL 1386
P CE PC K C HG C CQ G+ G C+ +D C + C++G
Sbjct: 344 PTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDD-CSPDPCLNGGSC 402
Query: 1387 PINAFSYSCKCLEGHGGVLCDE-EEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGD 1445
+Y+C C E G+ C+ + + + C + C +G + CEC G+ G
Sbjct: 403 VDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPEGFMG- 461
Query: 1446 SCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFE 1505
+ CR ER+ D + + G C + +C G G C + + + +
Sbjct: 462 -----LDCR-ERVPDDCECRNG-GRC-LGANTTLCQCPLGFFGLLCEFEITAMPCNMNTQ 513
Query: 1506 CTDG 1509
C DG
Sbjct: 514 CPDG 517
Score = 57.4 bits (137), Expect = 1e-07
Identities = 60/237 (25%), Positives = 88/237 (37%), Gaps = 44/237 (18%)
Query: 1318 QDFQKVPMQTGILPGCEPCHKKVCAHG-TCQPSSQAGFTCECQEGWMGPLCDQRTNDPC- 1375
+ F+ + +TG P + C C +G TC + Q G+ CEC EG+MG C +R D C
Sbjct: 415 EPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQ-GYVCECPEGFMGLDCRERVPDDCE 473
Query: 1376 --LGNKCVHGTC----LPINAFSYSCK-------------------CLEGHGGVLC---- 1406
G +C+ P+ F C+ C+E G LC
Sbjct: 474 CRNGGRCLGANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHT 533
Query: 1407 --DEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCD--REISCRGERIRD-- 1460
+ L +PC + C +G + CEC G+ G C+ R C R+
Sbjct: 534 DHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGG 593
Query: 1461 YYQKQQGYAACQTTKKVSRLECRGG----CAGGQC--CGPLRSKRRKYSFECTDGSS 1511
++ G C + + C G CA G C G KY +C G S
Sbjct: 594 TCKEAGGEYHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFS 650
Score = 57.0 bits (136), Expect = 1e-07
Identities = 48/180 (26%), Positives = 66/180 (36%), Gaps = 27/180 (15%)
Query: 1336 CHKKV--CAHGTCQPSSQA-----GFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPI 1388
CH V CA CQ F C+C G+ GP C + PC +C HG +
Sbjct: 308 CHLDVNECASQPCQNGGTCTHGINSFRCQCPAGFGGPTC-ETAQSPCDTKECQHGGQCQV 366
Query: 1389 NAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSC- 1447
S C C G+ G C+ + D C C +G + +G C C+ + G C
Sbjct: 367 ENGSAVCVCQAGYTGAACEMDVD---DCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCE 423
Query: 1448 -------DREISCRGERIRDYYQKQQGYAACQTTKKVSRLECR----GGCA---GGQCCG 1493
D +S QGY C+ + L+CR C GG+C G
Sbjct: 424 TGDHPVPDACLSAPCHNGGTCVDADQGY-VCECPEGFMGLDCRERVPDDCECRNGGRCLG 482
Score = 52.0 bits (123), Expect = 4e-06
Identities = 45/151 (29%), Positives = 62/151 (41%), Gaps = 29/151 (19%)
Query: 1374 PCL-GNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLG 1432
PCL G KC+ C+ N SY+C CL G G C + N C + C++G G+
Sbjct: 277 PCLNGGKCIDD-CVTGNP-SYTCSCLSGFTGRRCHLD---VNECASQPCQNGGTCTHGIN 331
Query: 1433 QPYCECSSGYTGDSCDREIS-CRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
C+C +G+ G +C+ S C D + Q G CQ + C+ G G C
Sbjct: 332 SFRCQCPAGFGGPTCETAQSPC------DTKECQHG-GQCQVENGSAVCVCQAGYTGAAC 384
Query: 1492 ------CGPLRSKRRKYSFECTDGSSFVDEV 1516
C P C +G S VD V
Sbjct: 385 EMDVDDCSP---------DPCLNGGSCVDLV 406
Score = 45.1 bits (105), Expect = 5e-04
Identities = 42/187 (22%), Positives = 58/187 (31%), Gaps = 50/187 (26%)
Query: 1335 PCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQ---------------RTNDPCLGNK 1379
PC + C +G F C CQ G+MG C R N LG
Sbjct: 660 PCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAV 719
Query: 1380 CVHG--------------TCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGK 1425
++ C P +S +CLE + C++ C HG
Sbjct: 720 ALYACDRGYSLSAPSRIRVCQPHGVWSEPPQCLE-------------IDECRSQPCLHGG 766
Query: 1426 CRLSGLGQPYCECSSGYTGDSCDRE-ISCRGERIRDYYQKQQGYAACQTTKKVSRLECRG 1484
+ C CS+GY G C+ E CR R+ +C+ C
Sbjct: 767 SCQDRVAGYLCLCSTGYEGAHCELERDECRAHPCRN-------GGSCRNLPGAYVCRCPA 819
Query: 1485 GCAGGQC 1491
G G C
Sbjct: 820 GFVGVHC 826
Score = 44.7 bits (104), Expect = 7e-04
Identities = 26/66 (39%), Positives = 31/66 (46%), Gaps = 18/66 (27%)
Query: 922 CLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACI--SNPCK------------ 967
C NPC+N GTC D + C C GFKG+ C++ ACI S PC
Sbjct: 1311 CSENPCQNGGTC-VPGADAHSCDCGPGFKGRRCEL---ACIKVSRPCTRLFSETKAFPVW 1366
Query: 968 HGGTCH 973
GG CH
Sbjct: 1367 EGGVCH 1372
Score = 42.0 bits (97), Expect = 0.005
Identities = 17/47 (36%), Positives = 25/47 (53%), Gaps = 3/47 (6%)
Query: 1001 DCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPC 1047
+C +N C+N TCV G + ++C C P + G CE C + PC
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELA---CIKVSRPC 1353
Score = 38.9 bits (89), Expect = 0.039
Identities = 20/80 (25%), Positives = 34/80 (42%), Gaps = 16/80 (20%)
Query: 1079 DCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDN-------FDCQ 1131
+C +N C+NG C + ++C C G+ G CE + + + PC F
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELA---CIKVSRPCTRLFSETKAFPVW 1366
Query: 1132 NGAQC------IVRINEPIC 1145
G C + R+++ IC
Sbjct: 1367 EGGVCHHVYKRVYRVHQDIC 1386
Score = 37.7 bits (86), Expect = 0.086
Identities = 16/37 (43%), Positives = 20/37 (54%), Gaps = 3/37 (8%)
Query: 961 CISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEV 997
C NPC++GGTC D C C GF+G CE+
Sbjct: 1311 CSENPCQNGGTC---VPGADAHSCDCGPGFKGRRCEL 1344
Score = 37.7 bits (86), Expect = 0.086
Identities = 13/33 (39%), Positives = 18/33 (54%)
Query: 1125 CDNFDCQNGAQCIVRINEPICQCLPGYQGEKCE 1157
C CQNG C+ + C C PG++G +CE
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCE 1343
Score = 37.4 bits (85), Expect = 0.11
Identities = 12/31 (38%), Positives = 17/31 (54%)
Query: 1045 NPCQHDSKCILTPKGFKCDCTPGYVGEHCDI 1075
NPCQ+ C+ CDC PG+ G C++
Sbjct: 1314 NPCQNGGTCVPGADAHSCDCGPGFKGRRCEL 1344
>gi|116235485 delta-notch-like EGF repeat-containing transmembrane
[Homo sapiens]
Length = 737
Score = 174 bits (440), Expect = 8e-43
Identities = 100/309 (32%), Positives = 141/309 (45%), Gaps = 47/309 (15%)
Query: 886 CAGPGEMADKLLLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTC-----NSDPVDF 940
C+G G+ K T S TC+ + + C PC+N+ +C D +F
Sbjct: 319 CSGKGKCTTKPSEATFS--CTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNF 376
Query: 941 YRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVD 1000
C C G+ G+ C I CI +PC++G TC GF C C +G+ G CE VD
Sbjct: 377 -TCVCLPGYTGELCQSKIDYCILDPCRNGATCI---SSLSGFTCQCPEGYFGSACEEKVD 432
Query: 1001 DCEDNDCENNSTC-VDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKG 1059
C + C+NN TC VDG++ +TC C P +TG C + +DFCA L+PC H + C
Sbjct: 433 PCASSPCQNNGTCYVDGVH-FTCNCSPGFTGPTCAQLIDFCA--LSPCAHGT-CRSVGTS 488
Query: 1060 FKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCE------- 1112
+KC C PGY G +C+ ++++C C N A C D VNGY C+C Y G CE
Sbjct: 489 YKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCA 548
Query: 1113 ------------------------FSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCL 1148
F+ + CD+ C +G C+ + N C C
Sbjct: 549 NVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCP 608
Query: 1149 PGYQGEKCE 1157
G+ G CE
Sbjct: 609 HGWVGANCE 617
Score = 129 bits (325), Expect = 2e-29
Identities = 70/199 (35%), Positives = 101/199 (50%), Gaps = 19/199 (9%)
Query: 966 CKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGI-----NNY 1020
C G C K E F C C + + G CE D C+ C+NN++C+D +N+
Sbjct: 319 CSGKGKCTTKPSEAT-FSCTCEEQYVGTFCE-EYDACQRKPCQNNASCIDANEKQDGSNF 376
Query: 1021 TCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDC 1080
TC+C P YTGELC+ K+D+C L+PC++ + CI + GF C C GY G C+ D C
Sbjct: 377 TCVCLPGYTGELCQSKIDYCI--LDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPC 434
Query: 1081 QDNKCKNGAHC-TDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVR 1139
+ C+N C D V+ +TC C G++G C + + SPC + C++
Sbjct: 435 ASSPCQNNGTCYVDGVH-FTCNCSPGFTGPTC--AQLIDFCALSPCAHGTCRSVGTSYK- 490
Query: 1140 INEPICQCLPGYQGEKCEK 1158
C C PGY G CE+
Sbjct: 491 -----CLCDPGYHGLYCEE 504
Score = 114 bits (286), Expect = 6e-25
Identities = 59/173 (34%), Positives = 80/173 (46%), Gaps = 17/173 (9%)
Query: 995 CEVNVDDCEDNDCENNSTCVDGINN--YTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSK 1052
C D +C C + ++C C +Y G CEE D C + PCQ+++
Sbjct: 307 CVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEE-YDACQR--KPCQNNAS 363
Query: 1053 CILTPK-----GFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYS 1107
CI + F C C PGY GE C D C + C+NGA C +++G+TC CPEGY
Sbjct: 364 CIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYF 423
Query: 1108 GLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKLV 1160
G CE + PC + CQN C V C C PG+ G C +L+
Sbjct: 424 GSACE-------EKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLI 469
Score = 104 bits (259), Expect = 7e-22
Identities = 118/470 (25%), Positives = 184/470 (39%), Gaps = 81/470 (17%)
Query: 1046 PCQHDSKCILTPK------------GFKCDCTPGYVGEHCDIDFDDCQDNKCKNG---AH 1090
PC++ C P+ G+ C C G G +C + D C N C +G +
Sbjct: 52 PCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSS 111
Query: 1091 CTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEP------- 1143
+ + +GY CIC EGY G CE + P LP T ++ Q + EP
Sbjct: 112 SSSSSDGYLCICNEGYEGPNCEQALPS-LPATGWTESM-APRQLQPVPATQEPDKILPRS 169
Query: 1144 -ICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGD 1202
LP +Q + +K+V + + E I ++ ++ + E K
Sbjct: 170 QATVTLPTWQPKTGQKVVEMKWDQVEVIPDIACGNASSNSSAGGRLVSFEVPQNTSVKIR 229
Query: 1203 KDHIAVELYRGRVRASYDTGSHPASAI--YSVETI--NDGNFHIVELLALDQSLSLS-VD 1257
+D A + +V A TG S I SV + + G + E+LAL + + V+
Sbjct: 230 QDATASLILLWKVTA---TGFQQCSLIDGRSVTPLQASGGLVLLEEMLALGNNHFIGFVN 286
Query: 1258 GGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLR-QAPGQNGT-----SFHGCIRNL 1311
K I L + + + PG+S+ L G+ T +F
Sbjct: 287 DSVTKSIVALRLTLVVKVSTCV-----PGESHANDLECSGKGKCTTKPSEATFSCTCEEQ 341
Query: 1312 YINSELQDF---QKVPMQTGI------------------LPGC--EPCHKKV-------C 1341
Y+ + +++ Q+ P Q LPG E C K+ C
Sbjct: 342 YVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPC 401
Query: 1342 AHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCV-HGTCLPINAFSYSCKCLEG 1400
+G SS +GFTC+C EG+ G C+++ DPC + C +GTC ++ ++C C G
Sbjct: 402 RNGATCISSLSGFTCQCPEGYFGSACEEKV-DPCASSPCQNNGTCY-VDGVHFTCNCSPG 459
Query: 1401 HGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDRE 1450
G C + L + C C HG CR G C C GY G C+ E
Sbjct: 460 FTGPTCAQ---LIDFCALSPCAHGTCRSVGTSYK-CLCDPGYHGLYCEEE 505
Score = 101 bits (251), Expect = 6e-21
Identities = 47/122 (38%), Positives = 66/122 (54%), Gaps = 8/122 (6%)
Query: 920 NPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEE 979
N CLS PC N TC D V+ Y C C +KG C++ C + C +G TC +
Sbjct: 507 NECLSAPCLNAATCR-DLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATC-----DS 560
Query: 980 DGF--WCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKL 1037
DG CICA GF GE C++++++C+ N C + +C+D N Y C CP + G CE L
Sbjct: 561 DGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHL 620
Query: 1038 DF 1039
+
Sbjct: 621 QW 622
Score = 86.3 bits (212), Expect = 2e-16
Identities = 41/112 (36%), Positives = 51/112 (45%), Gaps = 11/112 (9%)
Query: 896 LLLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDF-----------YRCT 944
LLL + + PV L+ PC + PC+N G C S P Y CT
Sbjct: 22 LLLGAGPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCT 81
Query: 945 CPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCE 996
CP G G +C + C SNPC HG DG+ CIC +G+EG NCE
Sbjct: 82 CPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
Score = 83.2 bits (204), Expect = 2e-15
Identities = 84/412 (20%), Positives = 156/412 (37%), Gaps = 68/412 (16%)
Query: 1080 CQDNKCKNGAHCTDAVN------------GYTCICPEGYSGLFCEF-SPPMVLPRTSPCD 1126
C C+NG CT GY+C CP G SG C+ + P ++PC
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCA---SNPCH 104
Query: 1127 NFDCQNGAQCIVRINEPICQCLPGYQGEKCEKLVS-------VNFINKESYLQIPSA--- 1176
+ +C + + + +C C GY+G CE+ + + +P+
Sbjct: 105 HGNCSSSSSS--SSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEP 162
Query: 1177 -KVRPQTNITLQIATDEDSG---ILLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSV 1232
K+ P++ T+ + T + ++ K D+ + ++ G ++ G S
Sbjct: 163 DKILPRSQATVTLPTWQPKTGQKVVEMKWDQVEVIPDIACGNASSNSSAGGRLVS----- 217
Query: 1233 ETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQSTLNFDSPLYVGG-----MPGK 1287
+ Q+ S+ + + L K + F + G +
Sbjct: 218 -------------FEVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDGRSVTPLQAS 264
Query: 1288 SNVASLRQAPGQNGTSFHGCIRNLYINSELQ-DFQKVPMQTGILPGCEPCHKKVCA-HGT 1345
+ L + F G + + S + V + +PG + C+ G
Sbjct: 265 GGLVLLEEMLALGNNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSGKGK 324
Query: 1346 CQPS-SQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHG-TCLPIN----AFSYSCKCLE 1399
C S+A F+C C+E ++G C++ D C C + +C+ N +++C CL
Sbjct: 325 CTTKPSEATFSCTCEEQYVGTFCEEY--DACQRKPCQNNASCIDANEKQDGSNFTCVCLP 382
Query: 1400 GHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREI 1451
G+ G LC + D C C++G +S L C+C GY G +C+ ++
Sbjct: 383 GYTGELCQSKIDY---CILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKV 431
Score = 71.6 bits (174), Expect = 5e-12
Identities = 49/156 (31%), Positives = 64/156 (41%), Gaps = 41/156 (26%)
Query: 1334 EPCHKKVCAH-GTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFS 1392
+PC C + GTC FTC C G+ GP C Q D C + C HGTC + S
Sbjct: 432 DPCASSPCQNNGTCYVDG-VHFTCNCSPGFTGPTCAQLI-DFCALSPCAHGTCRSVGT-S 488
Query: 1393 YSCKCLEGHGGVLCDEE---------------EDLFN--------------------PCQ 1417
Y C C G+ G+ C+EE DL N PC
Sbjct: 489 YKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCA 548
Query: 1418 AIKCKHGK-CRLSGLGQPYCECSSGYTGDSCDREIS 1452
+ C +G C GL C C+ G+TG+ CD +I+
Sbjct: 549 NVSCLNGATCDSDGLNGT-CICAPGFTGEECDIDIN 583
Score = 60.1 bits (144), Expect = 2e-08
Identities = 28/89 (31%), Positives = 40/89 (44%), Gaps = 12/89 (13%)
Query: 961 CISNPCKHGGTC---------HLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCEN-- 1009
C + PC++GG C H E G+ C C G G NC++ D C N C +
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 1010 -NSTCVDGINNYTCLCPPEYTGELCEEKL 1037
+S+ + Y C+C Y G CE+ L
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
Score = 55.5 bits (132), Expect = 4e-07
Identities = 36/150 (24%), Positives = 51/150 (34%), Gaps = 41/150 (27%)
Query: 1336 CHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTN----------------------- 1372
C CAHGTC+ S + C C G+ G C++ N
Sbjct: 472 CALSPCAHGTCR-SVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECV 530
Query: 1373 --------------DPCLGNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQA 1418
DPC C++G + + +C C G G CD + N C +
Sbjct: 531 CLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDID---INECDS 587
Query: 1419 IKCKHGKCRLSGLGQPYCECSSGYTGDSCD 1448
C HG L C C G+ G +C+
Sbjct: 588 NPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
Score = 51.2 bits (121), Expect = 8e-06
Identities = 31/100 (31%), Positives = 43/100 (43%), Gaps = 16/100 (16%)
Query: 1324 PMQTGILPGCEPCHKKVCAHG-TCQ-----------PSSQAGFTCECQEGWMGPLCDQRT 1371
P+ L PC + C +G C P+ + G++C C G G C Q
Sbjct: 36 PVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANC-QLV 94
Query: 1372 NDPCLGNKCVHGTCLPINAFS---YSCKCLEGHGGVLCDE 1408
DPC N C HG C ++ S Y C C EG+ G C++
Sbjct: 95 ADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
Score = 46.2 bits (108), Expect = 2e-04
Identities = 26/88 (29%), Positives = 33/88 (37%), Gaps = 17/88 (19%)
Query: 1002 CEDNDCENNSTCVD------------GINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQH 1049
C C N C G Y+C CP +G C+ D CA NPC H
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCAS--NPCHH 105
Query: 1050 ---DSKCILTPKGFKCDCTPGYVGEHCD 1074
S + G+ C C GY G +C+
Sbjct: 106 GNCSSSSSSSSDGYLCICNEGYEGPNCE 133
Score = 44.7 bits (104), Expect = 7e-04
Identities = 24/74 (32%), Positives = 30/74 (40%), Gaps = 1/74 (1%)
Query: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSY 1393
+PC C +G S TC C G+ G CD N+ C N C HG Y
Sbjct: 545 DPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINE-CDSNPCHHGGSCLDQPNGY 603
Query: 1394 SCKCLEGHGGVLCD 1407
+C C G G C+
Sbjct: 604 NCHCPHGWVGANCE 617
Score = 43.1 bits (100), Expect = 0.002
Identities = 27/93 (29%), Positives = 34/93 (36%), Gaps = 18/93 (19%)
Query: 1374 PCLGNKCVHG-TCL-----------PINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKC 1421
PC C +G C P YSC C G G C D PC + C
Sbjct: 47 PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVAD---PCASNPC 103
Query: 1422 KHGKCRLSGLGQP---YCECSSGYTGDSCDREI 1451
HG C S C C+ GY G +C++ +
Sbjct: 104 HHGNCSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 164 bits (416), Expect = 5e-40
Identities = 121/431 (28%), Positives = 200/431 (46%), Gaps = 26/431 (6%)
Query: 273 CPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLS 332
CP C C V C + L +P ++P I + + + AF L ++
Sbjct: 22 CPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFL 81
Query: 333 NNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAF 392
N Q+ + PDAF GL L L + G+ L ++F L SL L LN N + L F
Sbjct: 82 NTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLF 141
Query: 393 QDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIET 452
Q L L L L N+LQ + + F PL ++T++LAQN L L + L +P+ +
Sbjct: 142 QHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNL------LAQLPEELF-HPLTS 194
Query: 453 SGARCTSPRRLANKRIGQIKSKKF-RCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCR 511
+L+N + + F + + ++ F+ S+L F+ L C E+
Sbjct: 195 -----LQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNI--SELPPQVFSQLFCLERLW 247
Query: 512 CEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEA--TGIFKKLPQLRKINFSNNK 569
+ + +P I L + ++ +L G+F P L ++ ++N+
Sbjct: 248 LQRNAI-------THLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQ 300
Query: 570 ITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGL 629
+ + EG F S + ++L+ N + ++ +F+ LE L L L SN +T + F L
Sbjct: 301 LETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNL 360
Query: 630 SSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRK--KRIVTG 687
S + LLSL NQ+TT+ G FDT ++L L L NP+ C+C+LA+L WL++ R++
Sbjct: 361 SKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNI 420
Query: 688 NPRCQKPYFLK 698
C P +LK
Sbjct: 421 QTYCAGPAYLK 431
Score = 157 bits (396), Expect = 1e-37
Identities = 140/532 (26%), Positives = 218/532 (40%), Gaps = 90/532 (16%)
Query: 26 QACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDL--------------NGNNITRIT 71
Q CP C C V C L +VP +IP T+ + + N+T++
Sbjct: 20 QPCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVV 79
Query: 72 KTD----------FAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPEL 121
+ F GL L L++ + + F +L L +L LN N L+ PE
Sbjct: 80 FLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEG 139
Query: 122 LFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLT 181
LF A L L L NQ+QA+PR+ F+ +K L L N ++ + + F L L+ L
Sbjct: 140 LFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLK 199
Query: 182 LNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSH 241
L+NN ++ L F + L+ L SNN+ P+V C+
Sbjct: 200 LSNNALSGLPQGVFGKLGSLQELFLDSNNIS------------ELPPQVFSQLFCLERLW 247
Query: 242 LRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPET 301
L+ + + + F G+ +F++
Sbjct: 248 LQRNAITHLPLSIFASLGNLTFLS------------------------------------ 271
Query: 302 ITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKIT 361
L+ N ++V+P G F+ L + L++NQ+ +A F L +L SL+L N IT
Sbjct: 272 -----LQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAIT 326
Query: 362 ELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRA 421
LP +F L L L L +N + L FQ+L L LLSL N+L T+ +G F
Sbjct: 327 HLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYN 386
Query: 422 IQTMHLAQNPFICDCHLKWLADYL--HTNPIETSGARCTSPRRLANKRIGQIKSKKFRCS 479
+ + L NP+ CDCHL +L ++L +T+ + C P L + + + K+ C
Sbjct: 387 LFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKGQVVPALNEKQLVCP 446
Query: 480 AKEQYF-IPGTEDYRSKLSGDCFADLACPEKC---RC-----EGTTVDCSNQ 522
+ T SK G DLA E+ +C EGT V +Q
Sbjct: 447 VTRDHLGFQVTWPDESKAGGSW--DLAVQERAARSQCTYSNPEGTVVLACDQ 496
Score = 128 bits (321), Expect = 5e-29
Identities = 116/439 (26%), Positives = 194/439 (44%), Gaps = 52/439 (11%)
Query: 506 CPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINF 565
CP C C V CS+++L +P IP YT + FT LE T F P L K+ F
Sbjct: 22 CPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLE-TRAFGSNPNLTKVVF 80
Query: 566 SNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDS 625
N ++ AF G + ++ +T + N+ +F L SL L L N + +
Sbjct: 81 LNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGL 140
Query: 626 FIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLAN-----PFNCNCYLAWLGEWLR 680
F L+++ L L NQ+ + F L L TLNL N P L L
Sbjct: 141 FQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKL 200
Query: 681 KKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLS-RCPTECTCLDTVVR 739
++G P+ F K +Q++ + D N+ S L + ++ CL+ +
Sbjct: 201 SNNALSGLPQ---GVFGKLGSLQELFL---------DSNNISELPPQVFSQLFCLERLWL 248
Query: 740 CSNKGLKVLPKGIPR---DVTELYLDGNQFTLVPKEL-SNYKHLTLIDLSNNRISTLSNQ 795
N + LP I ++T L L N ++P L ++ L + L++N++ T++
Sbjct: 249 QRN-AITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEG 307
Query: 796 SFSNMTQLLTLILSYNRLRCIP------------------------PRTFDGLKSLRLLS 831
+F++++ L +L+LSYN + +P P F L L LLS
Sbjct: 308 TFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLS 367
Query: 832 LHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGI---ARCAG 888
L N ++ +PEG F+ L +LA+ NP CDC++ +L +W++ +Y + + CAG
Sbjct: 368 LSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQ-QYTDRLLNIQTYCAG 426
Query: 889 PGEMADKLLLTTPSKKFTC 907
P + +++ K+ C
Sbjct: 427 PAYLKGQVVPALNEKQLVC 445
Score = 58.9 bits (141), Expect = 4e-08
Identities = 42/164 (25%), Positives = 61/164 (37%), Gaps = 25/164 (15%)
Query: 723 PLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLV------------- 769
P CP C C V CS++ L +P IP + FT +
Sbjct: 18 PAQPCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTK 77
Query: 770 ------------PKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIP 817
P L ++++ + LS FSN+T L L L++N L +P
Sbjct: 78 VVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALP 137
Query: 818 PRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPL 861
F L +L L L GN + +P F L+ L L + N L
Sbjct: 138 EGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLL 181
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 153 bits (387), Expect = 1e-36
Identities = 115/449 (25%), Positives = 185/449 (41%), Gaps = 93/449 (20%)
Query: 960 ACISNPCKHGGTC--------HLKEGEE-----------DGFWCICADGFEGENCEVNVD 1000
+C+ PC++GG+C LK E F C C G+ G CE+++D
Sbjct: 3805 SCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDID 3864
Query: 1001 DCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGF 1060
+C + C + TC + + ++C CP +TG CE ++ C Q +PC++ + C P F
Sbjct: 3865 ECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINECLQ--SPCKNGAICQNFPGSF 3922
Query: 1061 KCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLP 1120
C C GY G+ C+ + C+ N C NG C V+ Y C CP G G CE
Sbjct: 3923 NCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYCHCPFGVFGKHCE-------- 3974
Query: 1121 RTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRP 1180
L Y E+ SY++ PS + P
Sbjct: 3975 ---------------------------LNSYGFEEL------------SYMEFPS--LDP 3993
Query: 1181 QTN-ITLQIATDEDSGILLYKGDK------DHIAVELYRGRVRASYDTGSHPASAIYSVE 1233
N I ++ AT + +LLY D + +A+E+ R+R SY+ GS + +++
Sbjct: 3994 NNNYIYVKFATIKSHALLLYNYDNQTGDRAEFLALEIAEERLRFSYNLGS-GTYKLTTMK 4052
Query: 1234 TINDGNFHIVELLALDQSLSLSVDGGNPK------IITNLSKQSTLNFD---SPLYVGGM 1284
++DG+FH V + SL+VD + ++N++ D + + VGG+
Sbjct: 4053 KVSDGHFHTVIARRAGMAASLTVDSCSENQEPGYCTVSNVAVSDDWTLDVQPNRVTVGGI 4112
Query: 1285 PGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILPGCE----PCHKKV 1340
+S L++ F GCI +N + + GIL C C +
Sbjct: 4113 --RSLEPILQRRGHVESHDFVGCIMEFAVNGRPLEPSQALAAQGILDQCPRLEGACTRSP 4170
Query: 1341 CAHGTCQPSSQAGFTCECQEGWMGPLCDQ 1369
C HG + C C+EG G C++
Sbjct: 4171 CQHGGTCMDYWSWQQCHCKEGLTGKYCEK 4199
Score = 123 bits (308), Expect = 2e-27
Identities = 54/176 (30%), Positives = 89/176 (50%), Gaps = 26/176 (14%)
Query: 922 CLSNPCKNDGTC---------------------NSDPVDFYRCTCPYGFKGQDCDVPIHA 960
C+ PC+N G+C ++P+ + C C G+ G C++ I
Sbjct: 3806 CVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDIDE 3865
Query: 961 CISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNY 1020
C+ +PC GGTCH G GF C C DGF G CE ++++C + C+N + C + ++
Sbjct: 3866 CLPSPCHSGGTCHNLVG---GFSCSCPDGFTGRACERDINECLQSPCKNGAICQNFPGSF 3922
Query: 1021 TCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDID 1076
C+C YTG++CE +++C + NPC + C + C C G G+HC+++
Sbjct: 3923 NCVCKTGYTGKMCESSVNYC--ECNPCFNGGSCQSGVDSYYCHCPFGVFGKHCELN 3976
Score = 72.4 bits (176), Expect = 3e-12
Identities = 53/177 (29%), Positives = 78/177 (44%), Gaps = 37/177 (20%)
Query: 1297 PGQNGTSFHGCIRNLYINSELQDFQKVPM-----------QTGILPG-----CE------ 1334
P QNG S C+R L ++S L+ + +P+ LPG CE
Sbjct: 3810 PCQNGGS---CLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDIDEC 3866
Query: 1335 ---PCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAF 1391
PCH + GTC + GF+C C +G+ G C++ N+ CL + C +G
Sbjct: 3867 LPSPCH----SGGTCH-NLVGGFSCSCPDGFTGRACERDINE-CLQSPCKNGAICQNFPG 3920
Query: 1392 SYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCD 1448
S++C C G+ G +C E N C+ C +G SG+ YC C G G C+
Sbjct: 3921 SFNCVCKTGYTGKMC---ESSVNYCECNPCFNGGSCQSGVDSYYCHCPFGVFGKHCE 3974
Score = 71.2 bits (173), Expect = 7e-12
Identities = 41/142 (28%), Positives = 63/142 (44%), Gaps = 13/142 (9%)
Query: 860 PLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPVDVNILA-- 917
P C C + W + + E + C G + + F+C P A
Sbjct: 3845 PFLCKCLPGYAGSWCEIDIDECLPSPCHSGGTCHNLV------GGFSCSCPDGFTGRACE 3898
Query: 918 -KCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKE 976
N CL +PCKN C + P F C C G+ G+ C+ ++ C NPC +GG+C +
Sbjct: 3899 RDINECLQSPCKNGAICQNFPGSF-NCVCKTGYTGKMCESSVNYCECNPCFNGGSC---Q 3954
Query: 977 GEEDGFWCICADGFEGENCEVN 998
D ++C C G G++CE+N
Sbjct: 3955 SGVDSYYCHCPFGVFGKHCELN 3976
Score = 58.9 bits (141), Expect = 4e-08
Identities = 41/118 (34%), Positives = 49/118 (41%), Gaps = 25/118 (21%)
Query: 899 TTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPI 958
T PS K C+GP N C SNPC D C + YRC VP
Sbjct: 4390 TDPSVKIGCRGP---------NICASNPCWGDLLCINQWYA-YRC------------VPP 4427
Query: 959 HACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDG 1016
C S+PC++GG+C + G GF C C D G CE+ V C C C G
Sbjct: 4428 GDCASHPCQNGGSC--EPGLHSGFTCSCPDSHTGRTCEM-VVACLGVLCPQGKVCKAG 4482
Score = 55.8 bits (133), Expect = 3e-07
Identities = 83/367 (22%), Positives = 136/367 (37%), Gaps = 85/367 (23%)
Query: 1125 CDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKLVSVNFI----------------NKE 1168
C CQ+G C+ + C C G G+ CEK V+ + K
Sbjct: 4166 CTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCEKSVTPDTALSLEGKGRLDYHMSQNEKR 4225
Query: 1169 SYL---QIPSAKVRP--QTNITLQIATDEDSGILLY-KGDKDHIAVELYRGRVRASYDTG 1222
YL + A + P ++ ++ T ++G+L++ + ++ V++ G+V + D G
Sbjct: 4226 EYLLRQSLRGAMLEPFGVNSLEVKFRTRSENGVLIHIQESSNYTTVKIKNGKVYFTSDAG 4285
Query: 1223 SHPASAIYSVET-INDGNFHIVELLALDQSLSLSVD------------------------ 1257
E + DG++H + + LSVD
Sbjct: 4286 IAGKVERNIPEVYVADGHWHTFLIGKNGTATVLSVDRIYNRDIIHPTQDFGGLDVLTISL 4345
Query: 1258 GGNPKIITNLSKQSTLNFD---SPLYVGG----MPGKSNVASLRQAP--------GQNGT 1302
GG P + Q T FD + ++ GG GK ++AS+ + G N
Sbjct: 4346 GGIPPNQAHRDAQ-TAGFDGCIASMWYGGESLPFSGKHSLASISKTDPSVKIGCRGPNIC 4404
Query: 1303 SFHGCIRNLYINSELQDFQKVPMQTGILPGCEPCHKKVCAHG-TCQPSSQAGFTCECQEG 1361
+ + C +L ++ ++ VP PG C C +G +C+P +GFTC C +
Sbjct: 4405 ASNPCWGDLLCINQWYAYRCVP------PG--DCASHPCQNGGSCEPGLHSGFTCSCPDS 4456
Query: 1362 WMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKC--LEGHGGVLCDEEEDLFNPCQAI 1419
G C+ CLG C G CK GH VL E++ P A+
Sbjct: 4457 HTGRTCEMVV--ACLGVLCPQGKV---------CKAGSPAGHVCVLSQGPEEISLPLWAV 4505
Query: 1420 KCKHGKC 1426
G C
Sbjct: 4506 PAIVGSC 4512
Score = 45.1 bits (105), Expect = 5e-04
Identities = 25/76 (32%), Positives = 36/76 (47%), Gaps = 15/76 (19%)
Query: 1038 DFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVN- 1096
+ CA NPC D CI ++C PG DC + C+NG C ++
Sbjct: 4402 NICAS--NPCWGDLLCINQWYAYRC-VPPG-----------DCASHPCQNGGSCEPGLHS 4447
Query: 1097 GYTCICPEGYSGLFCE 1112
G+TC CP+ ++G CE
Sbjct: 4448 GFTCSCPDSHTGRTCE 4463
Score = 42.4 bits (98), Expect = 0.003
Identities = 23/77 (29%), Positives = 34/77 (44%), Gaps = 20/77 (25%)
Query: 961 CISNPCKHGGTCHLKEGEEDGFW--CICADGFEGENCEVNVDDCEDNDCENNSTCVDGIN 1018
C SNPC W +C + + C V DC + C+N +C G++
Sbjct: 4404 CASNPC----------------WGDLLCINQWYAYRC-VPPGDCASHPCQNGGSCEPGLH 4446
Query: 1019 N-YTCLCPPEYTGELCE 1034
+ +TC CP +TG CE
Sbjct: 4447 SGFTCSCPDSHTGRTCE 4463
Score = 37.4 bits (85), Expect = 0.11
Identities = 23/77 (29%), Positives = 33/77 (42%), Gaps = 12/77 (15%)
Query: 927 CKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFW--- 983
C + N P++ + G Q C AC +PC+HGGTC +W
Sbjct: 4133 CIMEFAVNGRPLEPSQALAAQGILDQ-CPRLEGACTRSPCQHGGTCM-------DYWSWQ 4184
Query: 984 -CICADGFEGENCEVNV 999
C C +G G+ CE +V
Sbjct: 4185 QCHCKEGLTGKYCEKSV 4201
Score = 37.4 bits (85), Expect = 0.11
Identities = 26/106 (24%), Positives = 40/106 (37%), Gaps = 17/106 (16%)
Query: 1002 CEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCIL-TPKGF 1060
C N C + C++ Y C+ P + CA +PCQ+ C GF
Sbjct: 4404 CASNPCWGDLLCINQWYAYRCVPPGD------------CAS--HPCQNGGSCEPGLHSGF 4449
Query: 1061 KCDCTPGYVGEHCDIDFDDCQDNKCKNGAHC-TDAVNGYTCICPEG 1105
C C + G C++ C C G C + G+ C+ +G
Sbjct: 4450 TCSCPDSHTGRTCEM-VVACLGVLCPQGKVCKAGSPAGHVCVLSQG 4494
Score = 32.3 bits (72), Expect = 3.6
Identities = 19/59 (32%), Positives = 28/59 (47%), Gaps = 10/59 (16%)
Query: 901 PSKKFTCQGPVDVNILAKC----NPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCD 955
PS+ QG IL +C C +PC++ GTC D + +C C G G+ C+
Sbjct: 4146 PSQALAAQG-----ILDQCPRLEGACTRSPCQHGGTC-MDYWSWQQCHCKEGLTGKYCE 4198
Score = 31.6 bits (70), Expect = 6.2
Identities = 17/67 (25%), Positives = 26/67 (38%), Gaps = 6/67 (8%)
Query: 1405 LCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREI------SCRGERI 1458
+ D+ L C C+HG + C C G TG C++ + S G+
Sbjct: 4155 ILDQCPRLEGACTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCEKSVTPDTALSLEGKGR 4214
Query: 1459 RDYYQKQ 1465
DY+ Q
Sbjct: 4215 LDYHMSQ 4221
>gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 152 bits (383), Expect = 3e-36
Identities = 83/243 (34%), Positives = 123/243 (50%), Gaps = 36/243 (14%)
Query: 927 CKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNP-CKHGGTCHLKEGEEDGFWCI 985
C DG+C DP G++G C+ C+ P C+HG TCH + CI
Sbjct: 40 CAPDGSCRCDP----------GWEGLHCE----RCVRMPGCQHG-TCH------QPWQCI 78
Query: 986 CADGFEGENCEVNVDDCE-DNDCENNSTCV-DGINNYTCLCPPEYTGELCEEKLDFCAQD 1043
C G+ G+ C+ + C + C+N C+ DG Y C+C P + G CE K C Q
Sbjct: 79 CHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQA 138
Query: 1044 LNPCQHDSKCILTPKGFK----CDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYT 1099
+PC++ +C +GF C C G+VG C+++ DDC C NGA C D +N ++
Sbjct: 139 GSPCRNGGQC-QDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFS 197
Query: 1100 CICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKL 1159
C+CPEG++G FC + C + CQ GA+C R+++ C C GY G+ CE +
Sbjct: 198 CLCPEGFAGRFCTIN-------LDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELV 250
Query: 1160 VSV 1162
+ V
Sbjct: 251 LPV 253
Score = 146 bits (369), Expect = 1e-34
Identities = 73/211 (34%), Positives = 102/211 (48%), Gaps = 14/211 (6%)
Query: 919 CNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACIS-NPCKHGGTCHLKEG 977
C C+ P GTC+ ++C C G+ G+ CD H C + +PC++GG C G
Sbjct: 57 CERCVRMPGCQHGTCHQP----WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGG 112
Query: 978 EEDGFWCICADGFEGENCEVNVDDCED--NDCENNSTCVDGIN---NYTCLCPPEYTGEL 1032
E + C+C GF G +CE CE + C N C D N+TC C + G
Sbjct: 113 GE--YHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGAR 170
Query: 1033 CEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCT 1092
CE +D C + PC + + C+ F C C G+ G C I+ DDC C+ GA C
Sbjct: 171 CEVNVDDCL--MRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCR 228
Query: 1093 DAVNGYTCICPEGYSGLFCEFSPPMVLPRTS 1123
D V+ + C+CP GY G CE P+ P T+
Sbjct: 229 DRVHDFDCLCPSGYGGKTCELVLPVPDPPTT 259
Score = 67.8 bits (164), Expect = 8e-11
Identities = 49/158 (31%), Positives = 67/158 (42%), Gaps = 30/158 (18%)
Query: 1342 AHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGH 1401
AHG C P +C C GW G C++ P C HGTC + C C G
Sbjct: 36 AHGCCAPDG----SCRCDPGWEGLHCERCVRMP----GCQHGTCHQ----PWQCICHSGW 83
Query: 1402 GGVLCDEEEDLF---NPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREIS-CR--G 1455
G CD++E + +PCQ G+C G G+ +C C G+ G C+R+ C G
Sbjct: 84 AGKFCDKDEHICTTQSPCQ----NGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAG 139
Query: 1456 ERIRD--YYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
R+ Q QG+A T + C G G +C
Sbjct: 140 SPCRNGGQCQDDQGFALNFTCR------CLVGFVGARC 171
Score = 57.8 bits (138), Expect = 8e-08
Identities = 49/180 (27%), Positives = 62/180 (34%), Gaps = 59/180 (32%)
Query: 1333 CEPCHKKV-CAHGTCQPSSQAGFTCECQEGWMGPLCDQ-----RTNDPCL-GNKCV---- 1381
CE C + C HGTC Q C C GW G CD+ T PC G +C+
Sbjct: 57 CERCVRMPGCQHGTCHQPWQ----CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGG 112
Query: 1382 ---HGTCLP-------------------------------INAFSYSCKCLEGHGGVLCD 1407
H CLP A +++C+CL G G C+
Sbjct: 113 GEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCE 172
Query: 1408 EEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTG-------DSCDREISCRGERIRD 1460
D C C +G L G+ + C C G+ G D C RG R RD
Sbjct: 173 VNVD---DCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRD 229
Score = 57.4 bits (137), Expect = 1e-07
Identities = 43/121 (35%), Positives = 54/121 (44%), Gaps = 12/121 (9%)
Query: 1333 CEPCHKKVCAHGTCQPSS--QAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHG-TCLP-I 1388
CE G CQ FTC C G++G C+ +D CL C +G TCL I
Sbjct: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDD-CLMRPCANGATCLDGI 193
Query: 1389 NAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHG-KCRLSGLGQPYCECSSGYTGDSC 1447
N FS C C EG G C D C + C+ G +CR + C C SGY G +C
Sbjct: 194 NRFS--CLCPEGFAGRFCTINLD---DCASRPCQRGARCR-DRVHDFDCLCPSGYGGKTC 247
Query: 1448 D 1448
+
Sbjct: 248 E 248
>gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 152 bits (383), Expect = 3e-36
Identities = 83/243 (34%), Positives = 123/243 (50%), Gaps = 36/243 (14%)
Query: 927 CKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNP-CKHGGTCHLKEGEEDGFWCI 985
C DG+C DP G++G C+ C+ P C+HG TCH + CI
Sbjct: 40 CAPDGSCRCDP----------GWEGLHCE----RCVRMPGCQHG-TCH------QPWQCI 78
Query: 986 CADGFEGENCEVNVDDCE-DNDCENNSTCV-DGINNYTCLCPPEYTGELCEEKLDFCAQD 1043
C G+ G+ C+ + C + C+N C+ DG Y C+C P + G CE K C Q
Sbjct: 79 CHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQA 138
Query: 1044 LNPCQHDSKCILTPKGFK----CDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYT 1099
+PC++ +C +GF C C G+VG C+++ DDC C NGA C D +N ++
Sbjct: 139 GSPCRNGGQC-QDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFS 197
Query: 1100 CICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKL 1159
C+CPEG++G FC + C + CQ GA+C R+++ C C GY G+ CE +
Sbjct: 198 CLCPEGFAGRFCTIN-------LDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELV 250
Query: 1160 VSV 1162
+ V
Sbjct: 251 LPV 253
Score = 146 bits (369), Expect = 1e-34
Identities = 73/211 (34%), Positives = 102/211 (48%), Gaps = 14/211 (6%)
Query: 919 CNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACIS-NPCKHGGTCHLKEG 977
C C+ P GTC+ ++C C G+ G+ CD H C + +PC++GG C G
Sbjct: 57 CERCVRMPGCQHGTCHQP----WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGG 112
Query: 978 EEDGFWCICADGFEGENCEVNVDDCED--NDCENNSTCVDGIN---NYTCLCPPEYTGEL 1032
E + C+C GF G +CE CE + C N C D N+TC C + G
Sbjct: 113 GE--YHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGAR 170
Query: 1033 CEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCT 1092
CE +D C + PC + + C+ F C C G+ G C I+ DDC C+ GA C
Sbjct: 171 CEVNVDDCL--MRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCR 228
Query: 1093 DAVNGYTCICPEGYSGLFCEFSPPMVLPRTS 1123
D V+ + C+CP GY G CE P+ P T+
Sbjct: 229 DRVHDFDCLCPSGYGGKTCELVLPVPDPPTT 259
Score = 67.8 bits (164), Expect = 8e-11
Identities = 49/158 (31%), Positives = 67/158 (42%), Gaps = 30/158 (18%)
Query: 1342 AHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGH 1401
AHG C P +C C GW G C++ P C HGTC + C C G
Sbjct: 36 AHGCCAPDG----SCRCDPGWEGLHCERCVRMP----GCQHGTCHQ----PWQCICHSGW 83
Query: 1402 GGVLCDEEEDLF---NPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREIS-CR--G 1455
G CD++E + +PCQ G+C G G+ +C C G+ G C+R+ C G
Sbjct: 84 AGKFCDKDEHICTTQSPCQ----NGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAG 139
Query: 1456 ERIRD--YYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
R+ Q QG+A T + C G G +C
Sbjct: 140 SPCRNGGQCQDDQGFALNFTCR------CLVGFVGARC 171
Score = 57.8 bits (138), Expect = 8e-08
Identities = 49/180 (27%), Positives = 62/180 (34%), Gaps = 59/180 (32%)
Query: 1333 CEPCHKKV-CAHGTCQPSSQAGFTCECQEGWMGPLCDQ-----RTNDPCL-GNKCV---- 1381
CE C + C HGTC Q C C GW G CD+ T PC G +C+
Sbjct: 57 CERCVRMPGCQHGTCHQPWQ----CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGG 112
Query: 1382 ---HGTCLP-------------------------------INAFSYSCKCLEGHGGVLCD 1407
H CLP A +++C+CL G G C+
Sbjct: 113 GEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCE 172
Query: 1408 EEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTG-------DSCDREISCRGERIRD 1460
D C C +G L G+ + C C G+ G D C RG R RD
Sbjct: 173 VNVD---DCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRD 229
Score = 57.4 bits (137), Expect = 1e-07
Identities = 43/121 (35%), Positives = 54/121 (44%), Gaps = 12/121 (9%)
Query: 1333 CEPCHKKVCAHGTCQPSS--QAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHG-TCLP-I 1388
CE G CQ FTC C G++G C+ +D CL C +G TCL I
Sbjct: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDD-CLMRPCANGATCLDGI 193
Query: 1389 NAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHG-KCRLSGLGQPYCECSSGYTGDSC 1447
N FS C C EG G C D C + C+ G +CR + C C SGY G +C
Sbjct: 194 NRFS--CLCPEGFAGRFCTINLD---DCASRPCQRGARCR-DRVHDFDCLCPSGYGGKTC 247
Query: 1448 D 1448
+
Sbjct: 248 E 248
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 150 bits (379), Expect = 9e-36
Identities = 116/396 (29%), Positives = 175/396 (44%), Gaps = 60/396 (15%)
Query: 6 WQMLSLSLGLVLAILNKVAPQACPAQCSCSGS--TVDCHGLALRSVPRNIPRNTERLDLN 63
WQ + L LVL + + CP +C CS V CH +VP IP T LDL
Sbjct: 23 WQPILL---LVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLG 79
Query: 64 GNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLF 123
N I + + +FA HL L+L EN +S +E GAF +L L L L N L+L P +F
Sbjct: 80 KNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVF 139
Query: 124 LGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLN 183
G + L +LD+SEN+I + F+ ++K+L++ N + I AF L LE LTL
Sbjct: 140 TGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLE 199
Query: 184 NNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAW----------LSDWLRQRPRVGLY 233
N+T + + +H+ L RL N+ ++ +S W Y
Sbjct: 200 KCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHW--------PY 251
Query: 234 TQCMGPSHLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTE 293
M P+ L G N+ S S+ HC LT
Sbjct: 252 LDTMTPNCLYGLNLT------------------SLSITHC----------------NLTA 277
Query: 294 IPTNLPETITEIR---LEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSL 350
+P + +R L N I I +L+ I L Q++ + P AF+GL L
Sbjct: 278 VPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYL 337
Query: 351 NSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINC 386
L + GN++T L +S+F + +L+ L+L++N + C
Sbjct: 338 RVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLAC 373
Score = 116 bits (291), Expect = 1e-25
Identities = 120/455 (26%), Positives = 194/455 (42%), Gaps = 78/455 (17%)
Query: 267 SCSVLHCPAACTCS--NNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYK 324
S S CP C CS + V C K +P +P + L +N IK + F+ +
Sbjct: 36 SGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFP 95
Query: 325 KLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKI 384
L ++L+ N +S + P AF L +L +L L N++ +P +F GL +L L ++ NKI
Sbjct: 96 HLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKI 155
Query: 385 NCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADY 444
L FQDL+NL L + DN L I+ FS L +++ + L + C+L +
Sbjct: 156 VILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEK------CNLTSI--- 206
Query: 445 LHTNPIET-SGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDCFAD 503
P E S RL + I I+ F+ + + Y ++ +C
Sbjct: 207 ----PTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYG 262
Query: 504 LACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKI 563
L T++ ++ L +P Y A + L LR +
Sbjct: 263 LNL--------TSLSITHCNLTAVP-----YLA-----------------VRHLVYLRFL 292
Query: 564 NFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGN 623
N S N I+ IE S ++E+L RL+ +Q L ++ V
Sbjct: 293 NLSYNPISTIE------GSMLHELL----RLQEIQ--------------LVGGQLAVVEP 328
Query: 624 DSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRKKR 683
+F GL+ +R+L++ NQ+TT+ F ++ +L TL L +NP C+C L W+ +
Sbjct: 329 YAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLN 388
Query: 684 IVTGNPRCQKPYFL-----KEIPIQDVAIQD-FTC 712
P C P F+ K+ P DV + + FTC
Sbjct: 389 FNRQQPTCATPEFVQGKEFKDFP--DVLLPNYFTC 421
Score = 113 bits (282), Expect = 2e-24
Identities = 103/385 (26%), Positives = 166/385 (43%), Gaps = 45/385 (11%)
Query: 494 SKLSGDCFADLACPEKCRC--EGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEAT 551
S LSG CP +C C + V C ++ +PE IP T L L N L
Sbjct: 33 SVLSGSA---TGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQD 89
Query: 552 GIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTL 611
F P L ++ + N ++ +E GAF + + L SNRL+ + +F GL +L L
Sbjct: 90 E-FASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKL 148
Query: 612 MLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTL-----NLLANPF 666
+ N+I + + F L +++ L + DN + ++ AF L+SL L NL + P
Sbjct: 149 DISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPT 208
Query: 667 NCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSR 726
+L L LR + + N + Y K + V +S
Sbjct: 209 EALSHLHGL-IVLRLRHL---NINAIRDYSFKRLYRLKVL----------------EISH 248
Query: 727 CPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVP-KELSNYKHLTLIDLS 785
P LDT+ GL ++T L + T VP + + +L ++LS
Sbjct: 249 WP----YLDTMTPNCLYGL---------NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLS 295
Query: 786 NNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAF 845
N IST+ + +L + L +L + P F GL LR+L++ GN ++ + E F
Sbjct: 296 YNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVF 355
Query: 846 NDLSALSHLAIGANPLYCDCNMQWL 870
+ + L L + +NPL CDC + W+
Sbjct: 356 HSVGNLETLILDSNPLACDCRLLWV 380
Score = 68.6 bits (166), Expect = 5e-11
Identities = 66/219 (30%), Positives = 94/219 (42%), Gaps = 40/219 (18%)
Query: 58 ERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQL 117
E+L L N+T I + L L VL+L I+ I +F+ L L+ L ++
Sbjct: 194 EQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISH----- 248
Query: 118 FPELLFLGTAKLYRLDLSENQIQ-----AIPRKAFRGAVDIKNLQLDYNQISCIEDG--- 169
+P L + LY L+L+ I A+P A R V ++ L L YN IS IE
Sbjct: 249 WPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLH 308
Query: 170 ---------------------AFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHS 208
AFR L L VL ++ N +T L + F+ + L T L S
Sbjct: 309 ELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDS 368
Query: 209 NNLYCDCHLAWLSDWLRQRPRVGLYTQ---CMGPSHLRG 244
N L CDC L W+ R+R R+ Q C P ++G
Sbjct: 369 NPLACDCRLLWV---FRRRWRLNFNRQQPTCATPEFVQG 404
>gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens]
Length = 618
Score = 149 bits (376), Expect = 2e-35
Identities = 76/241 (31%), Positives = 101/241 (41%), Gaps = 38/241 (15%)
Query: 943 CTCPYGFKGQDCDVPIHA-----------------------CISNPCKHGGTCHLKEGEE 979
C C G+ G C VP+ C NPC +GG+C
Sbjct: 237 CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSC---SETP 293
Query: 980 DGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINN---YTCLCPPEYTGELCEEK 1036
F C C GF G CEV+ C D C N CV G + Y C CPP + G CE++
Sbjct: 294 RSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKR 353
Query: 1037 LDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVN 1096
+D C+ L PC++ C+ +C C G+ G C+ D DDC C NG C +
Sbjct: 354 VDRCS--LQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGG 411
Query: 1097 GYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKC 1156
+ C C G+ G C R PC C +G +C + +C C PGY G +C
Sbjct: 412 AHRCSCALGFGGRDCR-------ERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARC 464
Query: 1157 E 1157
E
Sbjct: 465 E 465
Score = 148 bits (374), Expect = 3e-35
Identities = 82/245 (33%), Positives = 104/245 (42%), Gaps = 20/245 (8%)
Query: 879 KEPGIARC----AGPGEMADKLLLTTPSKKFTC---QGPVDVN---ILAKCNPCLSNPCK 928
++PG RC GP L T P +C +GP ++ PC NPC
Sbjct: 232 EQPGECRCLEGWTGP-------LCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCA 284
Query: 929 NDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICAD 988
N G+C+ P F CTCP GF G C+V C PC +GG C + + C C
Sbjct: 285 NGGSCSETPRSF-ECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPP 343
Query: 989 GFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQ 1048
GF+G NCE VD C C N C+D + C C + G CE LD CA C
Sbjct: 344 GFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAG--RACA 401
Query: 1049 HDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSG 1108
+ C+ +C C G+ G C D C C +G C +G C C GY G
Sbjct: 402 NGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMG 461
Query: 1109 LFCEF 1113
CEF
Sbjct: 462 ARCEF 466
Score = 90.5 bits (223), Expect = 1e-17
Identities = 59/232 (25%), Positives = 85/232 (36%), Gaps = 42/232 (18%)
Query: 953 DCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDD----------- 1001
+C+ P+ C + G C + GE C C +G+ G C V V
Sbjct: 213 ECEAPL-VCRAGCSPEHGFCE-QPGE-----CRCLEGWTGPLCTVPVSTSSCLSPRGPSS 265
Query: 1002 ------------CEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQH 1049
C+ N C N +C + ++ C CP + G CE CA PC +
Sbjct: 266 ATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCAD--GPCFN 323
Query: 1050 DSKCIL---TPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGY 1106
C+ + C C PG+ G +C+ D C C+NG C D + C C G+
Sbjct: 324 GGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGF 383
Query: 1107 SGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEK 1158
+G CE C C NG C+ C C G+ G C +
Sbjct: 384 AGPRCEHD-------LDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRE 428
Score = 67.4 bits (163), Expect = 1e-10
Identities = 49/174 (28%), Positives = 64/174 (36%), Gaps = 41/174 (23%)
Query: 1021 TCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCIL--TPK-GF-----KCDCTPGYVGEH 1072
T LC P C L CA + C+ C +P+ GF +C C G+ G
Sbjct: 188 TRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGECRCLEGWTGPL 247
Query: 1073 CDIDFDD-----------------------CQDNKCKNGAHCTDAVNGYTCICPEGYSGL 1109
C + C N C NG C++ + C CP G+ GL
Sbjct: 248 CTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGL 307
Query: 1110 FCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEP---ICQCLPGYQGEKCEKLV 1160
CE S C + C NG C+ + IC C PG+QG CEK V
Sbjct: 308 RCEVS-------GVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRV 354
Score = 65.5 bits (158), Expect = 4e-10
Identities = 55/228 (24%), Positives = 75/228 (32%), Gaps = 63/228 (27%)
Query: 1294 RQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAG 1353
R AP + G C + L+D + P+ GC P HG C+ +
Sbjct: 194 RSAPSRCGPGLRPC-------APLEDECEAPLVCRA--GCSP------EHGFCEQPGE-- 236
Query: 1354 FTCECQEGWMGPLCDQRTN----------------------DPCLGNKCVHGTCLPINAF 1391
C C EGW GPLC + PC GN C +G
Sbjct: 237 --CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPR 294
Query: 1392 SYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGL--------GQPYCECSSGYT 1443
S+ C C G G+ C+ + C G C GL C C G+
Sbjct: 295 SFECTCPRGFYGLRCE--------VSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQ 346
Query: 1444 GDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
G +C++ + R Q + C R CR G AG +C
Sbjct: 347 GSNCEKRVD------RCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRC 388
Score = 63.9 bits (154), Expect = 1e-09
Identities = 30/78 (38%), Positives = 37/78 (47%), Gaps = 4/78 (5%)
Query: 922 CLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDG 981
C C N GTC + +RC+C GF G+DC C + PC HGG C+ G
Sbjct: 395 CAGRACANGGTC-VEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCY---AHFSG 450
Query: 982 FWCICADGFEGENCEVNV 999
C CA G+ G CE V
Sbjct: 451 LVCACAPGYMGARCEFPV 468
Score = 63.5 bits (153), Expect = 1e-09
Identities = 38/116 (32%), Positives = 50/116 (43%), Gaps = 10/116 (8%)
Query: 1336 CHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSC 1395
C + C +G C C+ G+ GP C+ +D C G C +G ++ C
Sbjct: 357 CSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDD-CAGRACANGGTCVEGGGAHRC 415
Query: 1396 KCLEGHGGVLCDEEEDLFNPCQAIKCKH-GKC--RLSGLGQPYCECSSGYTGDSCD 1448
C G GG C E D PC A C H G+C SGL C C+ GY G C+
Sbjct: 416 SCALGFGGRDCRERAD---PCAARPCAHGGRCYAHFSGL---VCACAPGYMGARCE 465
Score = 57.0 bits (136), Expect = 1e-07
Identities = 45/169 (26%), Positives = 63/169 (37%), Gaps = 19/169 (11%)
Query: 1329 ILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQR----TNDPCL-GNKCVHG 1383
++PG PC CA+G + F C C G+ G C+ + PC G CV G
Sbjct: 271 LVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGG 330
Query: 1384 TCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYT 1443
P +A Y C C G G C++ D C C++G L C C +G+
Sbjct: 331 AD-PDSA--YICHCPPGFQGSNCEKRVD---RCSLQPCRNGGLCLDLGHALRCRCRAGFA 384
Query: 1444 GDSCDREI-SCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
G C+ ++ C G + C R C G G C
Sbjct: 385 GPRCEHDLDDCAGRACAN-------GGTCVEGGGAHRCSCALGFGGRDC 426
Score = 43.1 bits (100), Expect = 0.002
Identities = 24/81 (29%), Positives = 31/81 (38%), Gaps = 5/81 (6%)
Query: 1331 PGCE----PCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCL 1386
P CE C + CA+G C C G+ G C +R DPC C HG
Sbjct: 386 PRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERA-DPCAARPCAHGGRC 444
Query: 1387 PINAFSYSCKCLEGHGGVLCD 1407
+ C C G+ G C+
Sbjct: 445 YAHFSGLVCACAPGYMGARCE 465
Score = 35.0 bits (79), Expect = 0.56
Identities = 13/42 (30%), Positives = 21/42 (50%), Gaps = 1/42 (2%)
Query: 918 KCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIH 959
+ +PC + PC + G C + C C G+ G C+ P+H
Sbjct: 429 RADPCAARPCAHGGRCYAHFSGLV-CACAPGYMGARCEFPVH 469
>gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens]
Length = 587
Score = 149 bits (376), Expect = 2e-35
Identities = 76/241 (31%), Positives = 101/241 (41%), Gaps = 38/241 (15%)
Query: 943 CTCPYGFKGQDCDVPIHA-----------------------CISNPCKHGGTCHLKEGEE 979
C C G+ G C VP+ C NPC +GG+C
Sbjct: 237 CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSC---SETP 293
Query: 980 DGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINN---YTCLCPPEYTGELCEEK 1036
F C C GF G CEV+ C D C N CV G + Y C CPP + G CE++
Sbjct: 294 RSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKR 353
Query: 1037 LDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVN 1096
+D C+ L PC++ C+ +C C G+ G C+ D DDC C NG C +
Sbjct: 354 VDRCS--LQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGG 411
Query: 1097 GYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKC 1156
+ C C G+ G C R PC C +G +C + +C C PGY G +C
Sbjct: 412 AHRCSCALGFGGRDCR-------ERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARC 464
Query: 1157 E 1157
E
Sbjct: 465 E 465
Score = 148 bits (374), Expect = 3e-35
Identities = 82/245 (33%), Positives = 104/245 (42%), Gaps = 20/245 (8%)
Query: 879 KEPGIARC----AGPGEMADKLLLTTPSKKFTC---QGPVDVN---ILAKCNPCLSNPCK 928
++PG RC GP L T P +C +GP ++ PC NPC
Sbjct: 232 EQPGECRCLEGWTGP-------LCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCA 284
Query: 929 NDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICAD 988
N G+C+ P F CTCP GF G C+V C PC +GG C + + C C
Sbjct: 285 NGGSCSETPRSF-ECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPP 343
Query: 989 GFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQ 1048
GF+G NCE VD C C N C+D + C C + G CE LD CA C
Sbjct: 344 GFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAG--RACA 401
Query: 1049 HDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSG 1108
+ C+ +C C G+ G C D C C +G C +G C C GY G
Sbjct: 402 NGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMG 461
Query: 1109 LFCEF 1113
CEF
Sbjct: 462 ARCEF 466
Score = 90.5 bits (223), Expect = 1e-17
Identities = 59/232 (25%), Positives = 85/232 (36%), Gaps = 42/232 (18%)
Query: 953 DCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDD----------- 1001
+C+ P+ C + G C + GE C C +G+ G C V V
Sbjct: 213 ECEAPL-VCRAGCSPEHGFCE-QPGE-----CRCLEGWTGPLCTVPVSTSSCLSPRGPSS 265
Query: 1002 ------------CEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQH 1049
C+ N C N +C + ++ C CP + G CE CA PC +
Sbjct: 266 ATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCAD--GPCFN 323
Query: 1050 DSKCIL---TPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGY 1106
C+ + C C PG+ G +C+ D C C+NG C D + C C G+
Sbjct: 324 GGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGF 383
Query: 1107 SGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEK 1158
+G CE C C NG C+ C C G+ G C +
Sbjct: 384 AGPRCEHD-------LDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRE 428
Score = 67.4 bits (163), Expect = 1e-10
Identities = 49/174 (28%), Positives = 64/174 (36%), Gaps = 41/174 (23%)
Query: 1021 TCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCIL--TPK-GF-----KCDCTPGYVGEH 1072
T LC P C L CA + C+ C +P+ GF +C C G+ G
Sbjct: 188 TRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGECRCLEGWTGPL 247
Query: 1073 CDIDFDD-----------------------CQDNKCKNGAHCTDAVNGYTCICPEGYSGL 1109
C + C N C NG C++ + C CP G+ GL
Sbjct: 248 CTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGL 307
Query: 1110 FCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEP---ICQCLPGYQGEKCEKLV 1160
CE S C + C NG C+ + IC C PG+QG CEK V
Sbjct: 308 RCEVS-------GVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRV 354
Score = 65.5 bits (158), Expect = 4e-10
Identities = 55/228 (24%), Positives = 75/228 (32%), Gaps = 63/228 (27%)
Query: 1294 RQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAG 1353
R AP + G C + L+D + P+ GC P HG C+ +
Sbjct: 194 RSAPSRCGPGLRPC-------APLEDECEAPLVCRA--GCSP------EHGFCEQPGE-- 236
Query: 1354 FTCECQEGWMGPLCDQRTN----------------------DPCLGNKCVHGTCLPINAF 1391
C C EGW GPLC + PC GN C +G
Sbjct: 237 --CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPR 294
Query: 1392 SYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGL--------GQPYCECSSGYT 1443
S+ C C G G+ C+ + C G C GL C C G+
Sbjct: 295 SFECTCPRGFYGLRCE--------VSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQ 346
Query: 1444 GDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
G +C++ + R Q + C R CR G AG +C
Sbjct: 347 GSNCEKRVD------RCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRC 388
Score = 63.9 bits (154), Expect = 1e-09
Identities = 30/78 (38%), Positives = 37/78 (47%), Gaps = 4/78 (5%)
Query: 922 CLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDG 981
C C N GTC + +RC+C GF G+DC C + PC HGG C+ G
Sbjct: 395 CAGRACANGGTC-VEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCY---AHFSG 450
Query: 982 FWCICADGFEGENCEVNV 999
C CA G+ G CE V
Sbjct: 451 LVCACAPGYMGARCEFPV 468
Score = 63.5 bits (153), Expect = 1e-09
Identities = 38/116 (32%), Positives = 50/116 (43%), Gaps = 10/116 (8%)
Query: 1336 CHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSC 1395
C + C +G C C+ G+ GP C+ +D C G C +G ++ C
Sbjct: 357 CSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDD-CAGRACANGGTCVEGGGAHRC 415
Query: 1396 KCLEGHGGVLCDEEEDLFNPCQAIKCKH-GKC--RLSGLGQPYCECSSGYTGDSCD 1448
C G GG C E D PC A C H G+C SGL C C+ GY G C+
Sbjct: 416 SCALGFGGRDCRERAD---PCAARPCAHGGRCYAHFSGL---VCACAPGYMGARCE 465
Score = 57.0 bits (136), Expect = 1e-07
Identities = 45/169 (26%), Positives = 63/169 (37%), Gaps = 19/169 (11%)
Query: 1329 ILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQR----TNDPCL-GNKCVHG 1383
++PG PC CA+G + F C C G+ G C+ + PC G CV G
Sbjct: 271 LVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGG 330
Query: 1384 TCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYT 1443
P +A Y C C G G C++ D C C++G L C C +G+
Sbjct: 331 AD-PDSA--YICHCPPGFQGSNCEKRVD---RCSLQPCRNGGLCLDLGHALRCRCRAGFA 384
Query: 1444 GDSCDREI-SCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
G C+ ++ C G + C R C G G C
Sbjct: 385 GPRCEHDLDDCAGRACAN-------GGTCVEGGGAHRCSCALGFGGRDC 426
Score = 43.1 bits (100), Expect = 0.002
Identities = 24/81 (29%), Positives = 31/81 (38%), Gaps = 5/81 (6%)
Query: 1331 PGCE----PCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCL 1386
P CE C + CA+G C C G+ G C +R DPC C HG
Sbjct: 386 PRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERA-DPCAARPCAHGGRC 444
Query: 1387 PINAFSYSCKCLEGHGGVLCD 1407
+ C C G+ G C+
Sbjct: 445 YAHFSGLVCACAPGYMGARCE 465
Score = 35.0 bits (79), Expect = 0.56
Identities = 13/42 (30%), Positives = 21/42 (50%), Gaps = 1/42 (2%)
Query: 918 KCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIH 959
+ +PC + PC + G C + C C G+ G C+ P+H
Sbjct: 429 RADPCAARPCAHGGRCYAHFSGLV-CACAPGYMGARCEFPVH 469
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 144 bits (362), Expect = 9e-34
Identities = 124/416 (29%), Positives = 191/416 (45%), Gaps = 44/416 (10%)
Query: 506 CPEKCRCEGTT--VDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKI 563
CP +C C T V C+ ++L +P+ IP T L L+ N L G LP L ++
Sbjct: 25 CPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNP-GDLAALPALEEL 83
Query: 564 NFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGN 623
+ S N I +E GAF + + L N+L+ + +F L++L L L N++ + +
Sbjct: 84 DLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLD 143
Query: 624 DSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRKKR 683
+F L S+R L + DN + V+ AF L +L L L CN A GE L
Sbjct: 144 YTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLE----RCNL-TALSGESL---- 194
Query: 684 IVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDG----NDDNSCSPLSRCPTECTCLDTVVR 739
G+ R L+ + I + Q+F G DN PL L+ V
Sbjct: 195 ---GHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNW--PL---------LEEVAA 240
Query: 740 CSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKE-LSNYKHLTLIDLSNNRISTLSNQSFS 798
S +GL ++T L + T VP L + HLT ++LS+N IST+ SF
Sbjct: 241 GSLRGL---------NLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFR 291
Query: 799 NMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGA 858
++ +L L L+ L + P+ F GL+ +RLL+L N +S + E F+ ++ L L +
Sbjct: 292 DLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDG 351
Query: 859 NPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPS----KKFTCQGP 910
NPL CDC + W+ K+ + + CA P E+ L P + F C+ P
Sbjct: 352 NPLACDCRLLWIVQRRKTLNFDGRLPACATPAEVRGDALRNLPDSVLFEYFVCRKP 407
Score = 137 bits (344), Expect = 1e-31
Identities = 117/378 (30%), Positives = 167/378 (44%), Gaps = 33/378 (8%)
Query: 13 LGLVLAILNKVAPQA--CPAQCSCSGST--VDCHGLALRSVPRNIPRNTERLDLNGNNIT 68
L L L +L P A CPA+C C+ T V C L +VP IP T L+L+ N I
Sbjct: 8 LSLPLLLLPAAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIR 67
Query: 69 RITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAK 128
+ D A L L L L EN I+ +E GAF +L L LRL N L+L P +F
Sbjct: 68 CLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDN 127
Query: 129 LYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNIT 188
L LDLSEN++ + F+ ++ L++ N + + AF L LE LTL N+T
Sbjct: 128 LTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLT 187
Query: 189 RLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVA 248
LS S H+ L RL HLA S L + + + G HL N
Sbjct: 188 ALSGESLGHLRSLGALRLR--------HLAIAS--LEDQN----FRRLPGLLHLEIDNWP 233
Query: 249 EVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLE 308
++ E + S SV H NI L +T + L
Sbjct: 234 LLE--EVAAGSLRGLNLTSLSVTH--------TNITAVPAAALRH-----QAHLTCLNLS 278
Query: 309 QNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLF 368
N I +P G+F +LR + L+ ++ + P AF GLR + L L N ++ L +S F
Sbjct: 279 HNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTF 338
Query: 369 EGLFSLQLLLLNANKINC 386
+ +L+ L ++ N + C
Sbjct: 339 HSVNTLETLRVDGNPLAC 356
Score = 115 bits (289), Expect = 2e-25
Identities = 93/354 (26%), Positives = 164/354 (46%), Gaps = 28/354 (7%)
Query: 273 CPAACTCS--NNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRID 330
CPA C C+ V C + LT +P +P + L +N I+ + PG + L +D
Sbjct: 25 CPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPALEELD 84
Query: 331 LSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVD 390
LS N I+ + P AF L L L L GN++ +P +F L +L LL L+ NK+ L
Sbjct: 85 LSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDY 144
Query: 391 AFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPI 450
FQDLH+L L + DN L +++ F+ L A++ + L + C+L L+
Sbjct: 145 TFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLER------CNLTALSG------- 191
Query: 451 ETSG-ARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPEK 509
E+ G R RL + I ++ + FR +PG + ++A
Sbjct: 192 ESLGHLRSLGALRLRHLAIASLEDQNFR-------RLPGLLHLEID-NWPLLEEVAAGSL 243
Query: 510 CRCEGTTVDCSNQKLNKIPEHIPQYTAE---LRLNNNEFTVLEATGIFKKLPQLRKINFS 566
T++ ++ + +P ++ A L L++N + + G F+ L +LR+++ +
Sbjct: 244 RGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTV-PRGSFRDLVRLRELHLA 302
Query: 567 NNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITC 620
+ +E AF G + + L++N L ++ F + +L+TL + N + C
Sbjct: 303 GALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLAC 356
Score = 79.3 bits (194), Expect = 3e-14
Identities = 57/211 (27%), Positives = 91/211 (43%), Gaps = 24/211 (11%)
Query: 58 ERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNR----- 112
E L L N+T ++ LR L L+L I+++E F+ L L L ++
Sbjct: 177 EELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLE 236
Query: 113 -------------------NHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDI 153
++ P A L L+LS N I +PR +FR V +
Sbjct: 237 EVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRL 296
Query: 154 KNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYC 213
+ L L ++ +E AF LR + +L L+NN ++ L ++F+ + L T R+ N L C
Sbjct: 297 RELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLAC 356
Query: 214 DCHLAWLSDWLRQRPRVGLYTQCMGPSHLRG 244
DC L W+ + G C P+ +RG
Sbjct: 357 DCRLLWIVQRRKTLNFDGRLPACATPAEVRG 387
Score = 79.0 bits (193), Expect = 3e-14
Identities = 49/142 (34%), Positives = 72/142 (50%), Gaps = 3/142 (2%)
Query: 723 PLSRCPTECTCL--DTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFT-LVPKELSNYKHL 779
P CP C C V C+ + L +P GIP + L L N+ L P +L+ L
Sbjct: 21 PAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPAL 80
Query: 780 TLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISV 839
+DLS N I+ + +F+N+ +L L L N+L+ IPP F L +L LL L N + +
Sbjct: 81 EELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVI 140
Query: 840 VPEGAFNDLSALSHLAIGANPL 861
+ + F DL +L L +G N L
Sbjct: 141 LLDYTFQDLHSLRRLEVGDNDL 162
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 141 bits (356), Expect = 4e-33
Identities = 100/347 (28%), Positives = 162/347 (46%), Gaps = 35/347 (10%)
Query: 1080 CQDNKCKNGAHCTDAVNG-YTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIV 1138
C+D C+NG C D+ + Y C+CP G++G CE S + C C A C+
Sbjct: 3848 CRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQAL------HCHPEACGPDATCVN 3901
Query: 1139 RINEP--ICQCLPGYQGEKCEKLVSV---NFINKESYLQIPS-AKVRPQTNITLQIATDE 1192
R + C+C G G +CE+ V+V + SYL +P+ + + ++
Sbjct: 3902 RPDGRGYTCRCHLGRSGLRCEEGVTVTTPSLSGAGSYLALPALTNTHHELRLDVEFKPLA 3961
Query: 1193 DSGILLYKGDK-----DHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLA 1247
G+LL+ G K D +++ + G + Y+ GS A + S E + G +H V
Sbjct: 3962 PDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLA-VLRSAEPLALGRWHRVSAER 4020
Query: 1248 LDQSLSLSVDGGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTS-FHG 1306
L++ SL V+GG P + ++ K LN + LY+GG+ S+ +P N ++ F G
Sbjct: 4021 LNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVE-----PSVPLSPATNMSAHFRG 4075
Query: 1307 CIRNLYINSELQDFQKVPMQTGILPGC---EPCHKKVCAHG-TCQPSSQAGFTCECQEGW 1362
C+ + +N + D + + + C PC ++ C HG TC P+ + F C C++G+
Sbjct: 4076 CVGEVSVNGKRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCLCRDGF 4135
Query: 1363 MGPLCDQRTNDPCLGNKCVH-GTCLPINAFSYSCKCLEGHGGVLCDE 1408
G LC+ N L C+H GTC C CL G G C +
Sbjct: 4136 KGDLCEHEENPCQLREPCLHGGTCQ-----GTRCLCLPGFSGPRCQQ 4177
Score = 82.4 bits (202), Expect = 3e-15
Identities = 72/265 (27%), Positives = 106/265 (40%), Gaps = 24/265 (9%)
Query: 1169 SYLQIPSAK-VRPQTNITLQIATDEDSGILLYKGDK--------------DHIAVELYRG 1213
S+L +P+ K + I + D G+LLY G K D I+ L G
Sbjct: 3672 SFLPLPTIKDAYRKFEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQPDFISFGLVGG 3731
Query: 1214 RVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQSTL 1273
R +D GS A+ I + G+FH V LL SL V P T+ K L
Sbjct: 3732 RPEFRFDAGSGMAT-IRHPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVNGTSQGKFQGL 3790
Query: 1274 NFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILPGC 1333
+ + LY+GG P + + G F GC+R L I E F + + + C
Sbjct: 3791 DLNEELYLGGYPDYGAIPKAGLSSG-----FIGCVRELRIQGEEIVFHDLNLTAHGISHC 3845
Query: 1334 EPCHKKVCAH-GTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKC-VHGTCL-PINA 1390
C + C + G C S + + C C G+ G C+ C C TC+ +
Sbjct: 3846 PTCRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDG 3905
Query: 1391 FSYSCKCLEGHGGVLCDEEEDLFNP 1415
Y+C+C G G+ C+E + P
Sbjct: 3906 RGYTCRCHLGRSGLRCEEGVTVTTP 3930
Score = 82.4 bits (202), Expect = 3e-15
Identities = 81/315 (25%), Positives = 131/315 (41%), Gaps = 63/315 (20%)
Query: 1045 NPCQHDSKCI--LTPKGFKCDCTPGYVGEH----CDIDFDDCQDNKCKNGAHCTDAVN-G 1097
N H C+ ++ G + D T ++G C D C+ C++GA C A
Sbjct: 4068 NMSAHFRGCVGEVSVNGKRLDLTYSFLGSQGIGQC-YDSSPCERQPCQHGATCMPAGEYE 4126
Query: 1098 YTCICPEGYSGLFCEFSPPMVLPRTSPCDNFD-CQNGAQCIVRINEPICQCLPGYQGEKC 1156
+ C+C +G+ G CE +PC + C +G C C CLPG+ G +C
Sbjct: 4127 FQCLCRDGFKGDLCEHEE-------NPCQLREPCLHGGTC----QGTRCLCLPGFSGPRC 4175
Query: 1157 EKLVSVN----------------------FINKESYLQIP------SAKVRPQTNITLQI 1188
++ + + + +L P S P+T I L++
Sbjct: 4176 QQGSGHGIAESDWHLEGSGGNDAPGQYGAYFHDDGFLAFPGHVFSRSLPEVPET-IELEV 4234
Query: 1189 ATDEDSGILLYKG--------DKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNF 1240
T SG+LL++G KD I++ L G + Y GS A + S + INDG +
Sbjct: 4235 RTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLV-SEDPINDGEW 4293
Query: 1241 HIVELLALDQSLSLSVDGGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQN 1300
H V L + S+ VDG + +N +Y+GG P +VA+L G+
Sbjct: 4294 HRVTALREGRRGSIQVDGEELVSGRSPGPNVAVNAKGSVYIGGAP---DVATL--TGGRF 4348
Query: 1301 GTSFHGCIRNLYINS 1315
+ GC++NL ++S
Sbjct: 4349 SSGITGCVKNLVLHS 4363
Score = 59.7 bits (143), Expect = 2e-08
Identities = 28/78 (35%), Positives = 38/78 (48%), Gaps = 8/78 (10%)
Query: 920 NPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHAC-ISNPCKHGGTCHLKEGE 978
+PC PC++ TC ++C C GFKG C+ + C + PC HGGTC
Sbjct: 4106 SPCERQPCQHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLREPCLHGGTC------ 4159
Query: 979 EDGFWCICADGFEGENCE 996
G C+C GF G C+
Sbjct: 4160 -QGTRCLCLPGFSGPRCQ 4176
Score = 58.5 bits (140), Expect = 5e-08
Identities = 29/77 (37%), Positives = 42/77 (54%), Gaps = 9/77 (11%)
Query: 961 CISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDG--IN 1018
C PC+HG TC + GE + F C+C DGF+G+ CE E+N C+ C+ G
Sbjct: 4108 CERQPCQHGATC-MPAGEYE-FQCLCRDGFKGDLCE-----HEENPCQLREPCLHGGTCQ 4160
Query: 1019 NYTCLCPPEYTGELCEE 1035
CLC P ++G C++
Sbjct: 4161 GTRCLCLPGFSGPRCQQ 4177
Score = 53.5 bits (127), Expect = 2e-06
Identities = 28/86 (32%), Positives = 37/86 (43%), Gaps = 4/86 (4%)
Query: 916 LAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCD--VPIHACISNPCKHGGTCH 973
++ C C PC+N G C+ Y C CP GF G C+ +H C C TC
Sbjct: 3842 ISHCPTCRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALH-CHPEACGPDATC- 3899
Query: 974 LKEGEEDGFWCICADGFEGENCEVNV 999
+ + G+ C C G G CE V
Sbjct: 3900 VNRPDGRGYTCRCHLGRSGLRCEEGV 3925
Score = 53.5 bits (127), Expect = 2e-06
Identities = 26/73 (35%), Positives = 38/73 (52%), Gaps = 6/73 (8%)
Query: 1002 CEDNDCENNSTCVD-GINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGF 1060
CE C++ +TC+ G + CLC + G+LCE + + C Q PC H C +G
Sbjct: 4108 CERQPCQHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPC-QLREPCLHGGTC----QGT 4162
Query: 1061 KCDCTPGYVGEHC 1073
+C C PG+ G C
Sbjct: 4163 RCLCLPGFSGPRC 4175
Score = 48.9 bits (115), Expect = 4e-05
Identities = 24/76 (31%), Positives = 34/76 (44%), Gaps = 4/76 (5%)
Query: 1002 CEDNDCENNSTCVDG-INNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTP--K 1058
C D C+N C D ++Y C+CP +TG CE C D+ C+ P +
Sbjct: 3848 CRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHP-EACGPDATCVNRPDGR 3906
Query: 1059 GFKCDCTPGYVGEHCD 1074
G+ C C G G C+
Sbjct: 3907 GYTCRCHLGRSGLRCE 3922
Score = 47.0 bits (110), Expect = 1e-04
Identities = 57/205 (27%), Positives = 77/205 (37%), Gaps = 58/205 (28%)
Query: 936 DP-VDFYRCTCPYGFKG---QDCD---------VPIHACISNPCKHG---------GTCH 973
DP ++ +C+CP G++G QDCD + + C C HG G C
Sbjct: 1118 DPALEVEQCSCPPGYRGPSCQDCDTGYTRTPSGLYLGTCERCSC-HGHSEACEPETGACQ 1176
Query: 974 LKEGEEDGFWC-ICADGFEGENCEVNVDDCEDNDCENN-------STC-VDGINNYTC-L 1023
+ +G C C G+ G+ DC+ C + TC +D + TC
Sbjct: 1177 GCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDA 1236
Query: 1024 CPPEYTGELCEEKLDFCAQDL-------NPCQHDSKCILTPKGFKCDCTP-GYVGEHCDI 1075
C P ++G CE CA PCQ DS+ P C+C P G V CD
Sbjct: 1237 CSPGHSGRHCER----CAPGYYGNPSQGQPCQRDSQ---VPGPIGCNCDPQGSVSSQCDA 1289
Query: 1076 DFDDCQDNKCKNGAHCTDAVNGYTC 1100
CQ C V G TC
Sbjct: 1290 -AGQCQ---------CKAQVEGLTC 1304
Score = 42.7 bits (99), Expect = 0.003
Identities = 42/155 (27%), Positives = 52/155 (33%), Gaps = 44/155 (28%)
Query: 1022 CLCPPEYTG----------------------ELCE--EKLDFCAQDLNPCQHDSKCILTP 1057
C CPP Y G ELCE D C + C S+C
Sbjct: 1530 CRCPPGYIGLSCQDCAPGYTRTGSGLYLGHCELCECNGHSDLCHPETGAC---SQCQHNA 1586
Query: 1058 KGFKCD-CTPGYVGEHCDIDFDDCQDNKC-------KNGAHCTD-AVNGYTC-ICPEGYS 1107
G C+ C PGY G+ +DCQ C C GY C C GY+
Sbjct: 1587 AGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYT 1646
Query: 1108 GLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINE 1142
G +CE P + S G QC+ N+
Sbjct: 1647 GQYCEQCGPGYVGNPS-------VQGGQCLPETNQ 1674
Score = 42.0 bits (97), Expect = 0.005
Identities = 57/210 (27%), Positives = 74/210 (35%), Gaps = 70/210 (33%)
Query: 943 CTCPYGFKG---QDC---------DVPIHACISNPCK-HGGTCHLKEG-------EEDGF 982
C CP G+ G QDC + + C C H CH + G G
Sbjct: 1530 CRCPPGYIGLSCQDCAPGYTRTGSGLYLGHCELCECNGHSDLCHPETGACSQCQHNAAGE 1589
Query: 983 WC-ICADGFEGENCEVNVDDCEDNDC-----EN--NSTCVD-GINNYTC-LCPPEYTGEL 1032
+C +CA G+ G+ +DC+ C EN + TC G Y C C P YTG+
Sbjct: 1590 FCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYTGQY 1649
Query: 1033 CEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKC---KNGA 1089
CE+ C PGYVG Q +C N A
Sbjct: 1650 CEQ----------------------------CGPGYVGN------PSVQGGQCLPETNQA 1675
Query: 1090 HCTDAVNGYTCICPEGYS-GLFCEF--SPP 1116
V+ I P+G S L C+ SPP
Sbjct: 1676 PLVVEVHPARSIVPQGGSHSLRCQVSGSPP 1705
Score = 41.6 bits (96), Expect = 0.006
Identities = 56/210 (26%), Positives = 75/210 (35%), Gaps = 55/210 (26%)
Query: 943 CTCPYGFKGQDCD--------VP----IHACISNPCK-HGGTCHLKEG-------EEDGF 982
C CP G+ G C+ VP + C C H +C G +G
Sbjct: 731 CRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEGP 790
Query: 983 WC-ICADGFEGENCEVNVDDCEDNDC-------ENNSTC-VDGINNYTC-LCPPEYTGEL 1032
C C GF G+ + C C + TC +D TC C P YTG
Sbjct: 791 QCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRR 850
Query: 1033 CEEKLDFCA--QDLNPCQHDSKC-ILTPKGFKCD--CTPGYVGEHCDIDFDDCQDNKCKN 1087
CE CA + NP Q KC + + +CD + G GE C +CKN
Sbjct: 851 CES----CAPGYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGEAC----------RCKN 896
Query: 1088 ---GAHCTDAVNGYTCIC---PEGYSGLFC 1111
G C + +G + P+G FC
Sbjct: 897 NVVGRLCNECADGSFHLSTRNPDGCLKCFC 926
Score = 38.9 bits (89), Expect = 0.039
Identities = 46/172 (26%), Positives = 62/172 (36%), Gaps = 45/172 (26%)
Query: 1022 CLCPPEYTGELCEE------------------------KLDFCAQDLNPCQHDSKCILTP 1057
C CPP Y G C++ + C + CQ C
Sbjct: 1126 CSCPPGYRGPSCQDCDTGYTRTPSGLYLGTCERCSCHGHSEACEPETGACQ---GCQHHT 1182
Query: 1058 KGFKCD-CTPGYVGEHCDIDFDDCQ------DNKCKNGAH-CTDAVNGY-TC-ICPEGYS 1107
+G +C+ C PGY G+ DCQ D AH C +G+ TC C G+S
Sbjct: 1183 EGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHS 1242
Query: 1108 GLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPI-CQCLP-GYQGEKCE 1157
G CE P +P CQ +Q + PI C C P G +C+
Sbjct: 1243 GRHCERCAPGYY--GNPSQGQPCQRDSQ----VPGPIGCNCDPQGSVSSQCD 1288
Score = 38.1 bits (87), Expect = 0.066
Identities = 41/192 (21%), Positives = 63/192 (32%), Gaps = 43/192 (22%)
Query: 955 DVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEV------------NVDDC 1002
D+ + +++ HG ++E C C G+ G +CE + C
Sbjct: 709 DIAMDTTVTHATSHGRAHSVEE-------CRCPIGYSGLSCESCDAHFTRVPGGPYLGTC 761
Query: 1003 EDNDCENNSTCVDGINNYTCLCPPEYTGELCE--------EKLDFCAQDLNPC------- 1047
+C +++ D + + C G C + + A PC
Sbjct: 762 SGCNCNGHASSCDPVYGHCLNCQHNTEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDA 821
Query: 1048 --QHDSKCILTPKG-FKCD-CTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICP 1103
+ C L G CD C PGY G C+ + N + G C VN C
Sbjct: 822 SRRFSDTCFLDTDGQATCDACAPGYTGRRCESCAPGYEGNPIQPGGKCR-PVNQEIVRCD 880
Query: 1104 E----GYSGLFC 1111
E G SG C
Sbjct: 881 ERGSMGTSGEAC 892
Score = 36.6 bits (83), Expect = 0.19
Identities = 23/59 (38%), Positives = 27/59 (45%), Gaps = 5/59 (8%)
Query: 919 CNPC---LSNPCKN-DGTCNSDPVDFYRCT-CPYGFKGQDCDVPIHACISNPCKHGGTC 972
C PC L+NP TC S YRCT C G+ GQ C+ + NP GG C
Sbjct: 1610 CQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQC 1668
Score = 36.2 bits (82), Expect = 0.25
Identities = 37/169 (21%), Positives = 54/169 (31%), Gaps = 36/169 (21%)
Query: 986 CADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCA---- 1041
CA G+ + + CE +C +S C GE CE CA
Sbjct: 1544 CAPGYTRTGSGLYLGHCELCECNGHSDLCHPETGACSQCQHNAAGEFCE----LCAPGYY 1599
Query: 1042 --------QDLNPC---------QHDSKC-ILTPKGFKCD-CTPGYVGEHCDIDFDDCQD 1082
+D PC C L G++C C PGY G++C+
Sbjct: 1600 GDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYTGQYCE-------- 1651
Query: 1083 NKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQ 1131
+C G +V G C+ + L E P + + CQ
Sbjct: 1652 -QCGPGYVGNPSVQGGQCLPETNQAPLVVEVHPARSIVPQGGSHSLRCQ 1699
Score = 35.8 bits (81), Expect = 0.33
Identities = 34/123 (27%), Positives = 40/123 (32%), Gaps = 26/123 (21%)
Query: 1061 KCDCTPGYVG---EHCDIDFD---------DCQDNKCKNGAHCTDAVNGYTCICPEGYSG 1108
+C C GY G E CD F C C A D V G+ C G
Sbjct: 730 ECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEG 789
Query: 1109 LFCE------FSPPMVLPRTS----PCDNFDCQN--GAQCIVRIN-EPICQ-CLPGYQGE 1154
C F M TS PC D C + + + C C PGY G
Sbjct: 790 PQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGR 849
Query: 1155 KCE 1157
+CE
Sbjct: 850 RCE 852
Score = 33.5 bits (75), Expect = 1.6
Identities = 32/111 (28%), Positives = 39/111 (35%), Gaps = 23/111 (20%)
Query: 1336 CHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSC 1395
CH + A CQ ++ F C G+ G D P C P N FS +C
Sbjct: 1572 CHPETGACSQCQHNAAGEFCELCAPGYYG---DATAGTPEDCQPCACPLTNPENMFSRTC 1628
Query: 1396 KCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCE-CSSGYTGD 1445
+ L G GG C C GQ YCE C GY G+
Sbjct: 1629 ESL-GAGGYRCT-----------------ACEPGYTGQ-YCEQCGPGYVGN 1660
Score = 32.0 bits (71), Expect = 4.7
Identities = 19/64 (29%), Positives = 24/64 (37%), Gaps = 5/64 (7%)
Query: 1100 CICPEGYSGLFCE-----FSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGE 1154
C CP GYSGL CE F+ P C +C A + C +G
Sbjct: 731 CRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEGP 790
Query: 1155 KCEK 1158
+C K
Sbjct: 791 QCNK 794
Score = 31.6 bits (70), Expect = 6.2
Identities = 31/123 (25%), Positives = 39/123 (31%), Gaps = 29/123 (23%)
Query: 1356 CECQEGWMGPLCDQ------RTNDPCLGNKC----VHG---TCLPINAFSYSC------- 1395
C C G+ GP C RT C HG C P C
Sbjct: 1126 CSCPPGYRGPSCQDCDTGYTRTPSGLYLGTCERCSCHGHSEACEPETGACQGCQHHTEGP 1185
Query: 1396 KCLEGHGGVLCDEEEDLFNPCQAIKC--------KHGKCRLSGLGQPYCE-CSSGYTGDS 1446
+C + G D + CQ C C L G P C+ CS G++G
Sbjct: 1186 RCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHSGRH 1245
Query: 1447 CDR 1449
C+R
Sbjct: 1246 CER 1248
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 140 bits (353), Expect = 9e-33
Identities = 129/430 (30%), Positives = 187/430 (43%), Gaps = 47/430 (10%)
Query: 11 LSLGLV-LAILNKVAPQACPAQCSCSGST-VDCHGLALRSVPRNIPRNTERLDLNGNNIT 68
L+LGL+ A + AP C A CSC G VDC G L +VP + T+ LD++ NNIT
Sbjct: 11 LALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNIT 70
Query: 69 RITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAK 128
++ + F L LQL N +S I A LKEL+ L L N L+ P G +
Sbjct: 71 QLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSA 130
Query: 129 LYRLDLSENQIQAIPRKAFRGAVDIKNLQLD------------------------YNQIS 164
L L L N I ++P +F G V +++L LD N+IS
Sbjct: 131 LQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKIS 190
Query: 165 CIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWL 224
I D AF L L VL L+NN I LS F+ + L T L+ NNL L
Sbjct: 191 SIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNL---GEFPQAIKAL 247
Query: 225 RQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSGHQSFMAPSC----SVLHCPAACTCS 280
+G ++ + + + + + SF+ S S LH
Sbjct: 248 PSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHS------- 300
Query: 281 NNIVDCRGKGLTEIPTNLPETI--TEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISE 338
+ RG + + NL T+ + L I IP K LR +DLS N I +
Sbjct: 301 ---LVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRD 357
Query: 339 LAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNL 398
L +F G +L + L N+I ++ + F+GL SL++L L+ N I+ + AF L +
Sbjct: 358 L--PSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPI 415
Query: 399 NLLSLYDNKL 408
L + N+L
Sbjct: 416 TNLDVSFNEL 425
Score = 121 bits (304), Expect = 5e-27
Identities = 114/418 (27%), Positives = 176/418 (42%), Gaps = 73/418 (17%)
Query: 273 CPAACTCSNNI-VDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDL 331
C A C+C + VDC GKGLT +P L + + N I +P AF + L + L
Sbjct: 29 CAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQL 88
Query: 332 SNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDA 391
+ N +S + P A GL+ L L L N++ +P GL +LQ L L+AN I + D+
Sbjct: 89 AGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDS 148
Query: 392 FQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIE 451
F+ L L L L DN L + S L +Q + LA N + + D+ TN
Sbjct: 149 FEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALN------KISSIPDFAFTN--- 199
Query: 452 TSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCR 511
L++ + + + K R LS CF L E
Sbjct: 200 -----------LSSLVVLHLHNNKIR-----------------SLSQHCFDGLDNLE--- 228
Query: 512 CEGTTVDCSNQKLNKIPEHIPQYTA--ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNK 569
T+D + L + P+ I + EL ++N +V+ G F P LR I+ +N
Sbjct: 229 ----TLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVI-PDGAFDGNPLLRTIHLYDNP 283
Query: 570 ITDIEEGAF-----------EGASGVNE------------ILLTSNRLENVQHKMFKGLE 606
++ + AF GAS V + + LT ++ ++ + + + +
Sbjct: 284 LSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQK 343
Query: 607 SLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLAN 664
L+TL L N I + SF G ++ +SL NQI + G F L SL L+L N
Sbjct: 344 MLRTLDLSYNNIRDL--PSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRN 399
Score = 110 bits (274), Expect = 1e-23
Identities = 99/385 (25%), Positives = 165/385 (42%), Gaps = 39/385 (10%)
Query: 506 CPEKCRCEGTT-VDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKIN 564
C C C+G VDCS + L +PE + +T L ++ N T L FK P L ++
Sbjct: 29 CAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDA-FKNFPFLEELQ 87
Query: 565 FSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGND 624
+ N ++ I A G + + L +N+L+ V + +GL +L++L L +N IT V D
Sbjct: 88 LAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPED 147
Query: 625 SFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGE------W 678
SF GL +R L L DN +T V L +L L L N + A+
Sbjct: 148 SFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLH 207
Query: 679 LRKKRIVTGNPRC------------------QKPYFLKEIPIQDVAIQDFTCDDGNDDNS 720
L +I + + C + P +K +P ++++ G NS
Sbjct: 208 LHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALP----SLKEL----GFHSNS 259
Query: 721 CSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELY---LDGNQFTLVPKELSNYK 777
S + + L + + L + ++++L+ + G L+
Sbjct: 260 ISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTV 319
Query: 778 HLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDI 837
HL + L+ +IS++ N L TL LSYN +R +P +F+G +L +SL N I
Sbjct: 320 HLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLP--SFNGCHALEEISLQRNQI 377
Query: 838 SVVPEGAFNDLSALSHLAIGANPLY 862
+ EG F L +L L + N ++
Sbjct: 378 YQIKEGTFQGLISLRILDLSRNLIH 402
Score = 68.9 bits (167), Expect = 3e-11
Identities = 72/313 (23%), Positives = 136/313 (43%), Gaps = 17/313 (5%)
Query: 524 LNKIPEHIPQYTAELR---LNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEG 580
+ +PE + +LR L++N T + + LP L+ + + NKI+ I + AF
Sbjct: 141 ITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPL-SNLPTLQALTLALNKISSIPDFAFTN 199
Query: 581 ASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDN 640
S + + L +N++ ++ F GL++L+TL L N + + L S++ L + N
Sbjct: 200 LSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLG-EFPQAIKALPSLKELGFHSN 258
Query: 641 QITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQK-PYFLKE 699
I+ + GAFD L T++L NP + A+ ++ G Q+ P
Sbjct: 259 SISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGT 318
Query: 700 IPIQDVAIQDFTCDDGNDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPK-GIPRDVTE 758
+ ++ + + T +N C T + S ++ LP + E
Sbjct: 319 VHLESLTLTG-TKISSIPNNLCQEQKMLRT--------LDLSYNNIRDLPSFNGCHALEE 369
Query: 759 LYLDGNQ-FTLVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIP 817
+ L NQ + + L ++DLS N I + +++F+ + + L +S+N L P
Sbjct: 370 ISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFP 429
Query: 818 PRTFDGLKSLRLL 830
+GL L+L+
Sbjct: 430 TEGLNGLNQLKLV 442
Score = 55.5 bits (132), Expect = 4e-07
Identities = 39/129 (30%), Positives = 58/129 (44%), Gaps = 2/129 (1%)
Query: 74 DFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLD 133
+ G HL L L KIS+I Q+ K L L L+ N+++ P F G L +
Sbjct: 314 NLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS--FNGCHALEEIS 371
Query: 134 LSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVA 193
L NQI I F+G + ++ L L N I I AF L + L ++ N +T
Sbjct: 372 LQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTE 431
Query: 194 SFNHMPKLR 202
N + +L+
Sbjct: 432 GLNGLNQLK 440
Score = 53.9 bits (128), Expect = 1e-06
Identities = 44/148 (29%), Positives = 62/148 (41%), Gaps = 9/148 (6%)
Query: 40 DCHGLALR--SVPRNIPRNT-----ERLDLNGNNITRITKTDFAGLRHLRVLQLMENKIS 92
D H L +R S+ + P T E L L G I+ I + LR L L N I
Sbjct: 297 DLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIR 356
Query: 93 TIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVD 152
+ +F LE + L RN + E F G L LDLS N I I +AF
Sbjct: 357 DLP--SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGP 414
Query: 153 IKNLQLDYNQISCIEDGAFRALRDLEVL 180
I NL + +N+++ L L+++
Sbjct: 415 ITNLDVSFNELTSFPTEGLNGLNQLKLV 442
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.438
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,919,576
Number of Sequences: 37866
Number of extensions: 3270512
Number of successful extensions: 23598
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 353
Number of HSP's successfully gapped in prelim test: 342
Number of HSP's that attempted gapping in prelim test: 6859
Number of HSP's gapped (non-prelim): 7032
length of query: 1529
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1414
effective length of database: 13,892,928
effective search space: 19644600192
effective search space used: 19644600192
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.