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Search of human proteins with 4758952
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4758952 protein phosphatase 2, catalytic subunit, beta
isoform [Homo sapiens]
(309 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|57222565 protein phosphatase 2, catalytic subunit, beta isofo... 656 0.0
gi|4758952 protein phosphatase 2, catalytic subunit, beta isofor... 656 0.0
gi|4506017 protein phosphatase 2, catalytic subunit, alpha isofo... 642 0.0
gi|4506027 protein phosphatase 4, catalytic subunit [Homo sapiens] 439 e-123
gi|4506029 protein phosphatase 6, catalytic subunit isoform b [H... 376 e-104
gi|183603929 protein phosphatase 6, catalytic subunit isoform a ... 359 2e-99
gi|183603931 protein phosphatase 6, catalytic subunit isoform c ... 328 3e-90
gi|4506007 protein phosphatase 1, catalytic subunit, gamma isofo... 303 2e-82
gi|56790945 protein phosphatase 1, catalytic subunit, alpha isof... 300 1e-81
gi|4506003 protein phosphatase 1, catalytic subunit, alpha isofo... 300 1e-81
gi|46249376 protein phosphatase 1, catalytic subunit, beta isofo... 290 1e-78
gi|4506005 protein phosphatase 1, catalytic subunit, beta isofor... 290 1e-78
gi|239752750 PREDICTED: similar to protein phosphatase 2, cataly... 273 1e-73
gi|239747318 PREDICTED: similar to protein phosphatase 2, cataly... 271 5e-73
gi|239741140 PREDICTED: similar to protein phosphatase 2, cataly... 271 5e-73
gi|45827798 protein phosphatase 1, catalytic subunit, alpha isof... 271 7e-73
gi|5453958 protein phosphatase 5, catalytic subunit [Homo sapiens] 235 4e-62
gi|194688147 protein phosphatase 3, catalytic subunit, alpha iso... 227 1e-59
gi|6715568 protein phosphatase 3, catalytic subunit, alpha isofo... 227 1e-59
gi|215272354 protein phosphatase 3, catalytic subunit, beta isof... 223 1e-58
gi|215272352 protein phosphatase 3, catalytic subunit, beta isof... 223 1e-58
gi|11036640 protein phosphatase 3, catalytic subunit, beta isofo... 223 1e-58
gi|194688149 protein phosphatase 3, catalytic subunit, alpha iso... 220 1e-57
gi|21361290 protein phosphatase 3, catalytic subunit, gamma [Hom... 215 3e-56
gi|23312374 protein phosphatase with EF hand calcium-binding dom... 148 7e-36
gi|23312380 protein phosphatase with EF hand calcium-binding dom... 137 1e-32
gi|23312386 serine/threonine protein phosphatase with EF-hand mo... 110 1e-24
gi|23312378 protein phosphatase with EF hand calcium-binding dom... 103 1e-22
gi|169217489 PREDICTED: similar to phosphodiesterase 4D interact... 29 4.6
gi|29789379 sphingomyelin synthase 1 [Homo sapiens] 29 4.6
>gi|57222565 protein phosphatase 2, catalytic subunit, beta isoform
[Homo sapiens]
Length = 309
Score = 656 bits (1692), Expect = 0.0
Identities = 309/309 (100%), Positives = 309/309 (100%)
Query: 1 MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHG 60
MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHG
Sbjct: 1 MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHG 60
Query: 61 QFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHES 120
QFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHES
Sbjct: 61 QFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHES 120
Query: 121 RQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHI 180
RQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHI
Sbjct: 121 RQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHI 180
Query: 181 RALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRA 240
RALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRA
Sbjct: 181 RALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRA 240
Query: 241 HQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHV 300
HQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHV
Sbjct: 241 HQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHV 300
Query: 301 TRRTPDYFL 309
TRRTPDYFL
Sbjct: 301 TRRTPDYFL 309
>gi|4758952 protein phosphatase 2, catalytic subunit, beta isoform
[Homo sapiens]
Length = 309
Score = 656 bits (1692), Expect = 0.0
Identities = 309/309 (100%), Positives = 309/309 (100%)
Query: 1 MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHG 60
MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHG
Sbjct: 1 MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHG 60
Query: 61 QFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHES 120
QFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHES
Sbjct: 61 QFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHES 120
Query: 121 RQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHI 180
RQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHI
Sbjct: 121 RQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHI 180
Query: 181 RALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRA 240
RALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRA
Sbjct: 181 RALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRA 240
Query: 241 HQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHV 300
HQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHV
Sbjct: 241 HQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHV 300
Query: 301 TRRTPDYFL 309
TRRTPDYFL
Sbjct: 301 TRRTPDYFL 309
>gi|4506017 protein phosphatase 2, catalytic subunit, alpha isoform
[Homo sapiens]
Length = 309
Score = 642 bits (1657), Expect = 0.0
Identities = 301/309 (97%), Positives = 307/309 (99%)
Query: 1 MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHG 60
MD+K FTKELDQW+EQLNECKQL+E+QV++LCEKAKEILTKESNVQEVRCPVTVCGDVHG
Sbjct: 1 MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHG 60
Query: 61 QFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHES 120
QFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRY ERITILRGNHES
Sbjct: 61 QFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHES 120
Query: 121 RQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHI 180
RQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHI
Sbjct: 121 RQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHI 180
Query: 181 RALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRA 240
RALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRA
Sbjct: 181 RALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRA 240
Query: 241 HQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHV 300
HQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHV
Sbjct: 241 HQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHV 300
Query: 301 TRRTPDYFL 309
TRRTPDYFL
Sbjct: 301 TRRTPDYFL 309
>gi|4506027 protein phosphatase 4, catalytic subunit [Homo sapiens]
Length = 307
Score = 439 bits (1128), Expect = e-123
Identities = 200/303 (66%), Positives = 248/303 (81%), Gaps = 3/303 (0%)
Query: 9 ELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMEL 68
+LD+ +EQL C+ + E++V+ LC KA+EIL +ESNVQ V PVTVCGD+HGQF+DL EL
Sbjct: 6 DLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKEL 65
Query: 69 FRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYG 128
FR+GG P+TNYLFMGD+VDRG+YSVET LL+ALKVRYP+RIT++RGNHESRQITQVYG
Sbjct: 66 FRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYG 125
Query: 129 FYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQE 188
FYDECLRKYG+ VW+Y T++FDYL L+A++DG+IFC+HGGLSPSI TLD IR +DR QE
Sbjct: 126 FYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQE 185
Query: 189 VPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGY 248
VPH+GPMCDLLWSDP+D GWG+SPRGAGY FG D+ FN AN + ++ RAHQLVMEGY
Sbjct: 186 VPHDGPMCDLLWSDPEDTTGWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGY 245
Query: 249 NWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPR--RGEPHVTRRTPD 306
W + V+T++SAPNYCYRCGN AAI+ELD+ L+ F+ F+ AP+ RG P + D
Sbjct: 246 KWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQETRGIPS-KKPVAD 304
Query: 307 YFL 309
YFL
Sbjct: 305 YFL 307
>gi|4506029 protein phosphatase 6, catalytic subunit isoform b [Homo
sapiens]
Length = 305
Score = 376 bits (966), Expect = e-104
Identities = 177/301 (58%), Positives = 217/301 (72%)
Query: 9 ELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMEL 68
+LD++VE CK L EN ++ LC+ ++L +ESNVQ V PVTVCGD+HGQF+DL EL
Sbjct: 5 DLDKYVEIARLCKYLPENDLKRLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCEL 64
Query: 69 FRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYG 128
FR GG+ PDTNY+FMGD+VDRGYYS+ET T L+ALK ++P+RIT+LRGNHESRQITQVYG
Sbjct: 65 FRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYG 124
Query: 129 FYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQE 188
FYDEC KYGNAN W+Y T +FD L + AL+D QI C+HGGLSP I TLD IR ++R QE
Sbjct: 125 FYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQE 184
Query: 189 VPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGY 248
+PH+G CDL+WSDP+D W ISPRGAG+ FG ++ F H N L L+ RAHQLV EGY
Sbjct: 185 IPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGY 244
Query: 249 NWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYF 308
+ D +VT++SAPNYCYRCGN A+IM D F P R T YF
Sbjct: 245 KFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFRAVPDSERVIPPRTTTPYF 304
Query: 309 L 309
L
Sbjct: 305 L 305
>gi|183603929 protein phosphatase 6, catalytic subunit isoform a
[Homo sapiens]
Length = 342
Score = 359 bits (921), Expect = 2e-99
Identities = 168/279 (60%), Positives = 203/279 (72%)
Query: 31 LCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRG 90
LC+ ++L +ESNVQ V PVTVCGD+HGQF+DL ELFR GG+ PDTNY+FMGD+VDRG
Sbjct: 64 LCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRG 123
Query: 91 YYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLF 150
YYS+ET T L+ALK ++P+RIT+LRGNHESRQITQVYGFYDEC KYGNAN W+Y T +F
Sbjct: 124 YYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVF 183
Query: 151 DYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWG 210
D L + AL+D QI C+HGGLSP I TLD IR ++R QE+PH+G CDL+WSDP+D W
Sbjct: 184 DMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWA 243
Query: 211 ISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCG 270
ISPRGAG+ FG ++ F H N L L+ RAHQLV EGY + D +VT++SAPNYCYRCG
Sbjct: 244 ISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCG 303
Query: 271 NQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL 309
N A+IM D F P R T YFL
Sbjct: 304 NIASIMVFKDVNTREPKLFRAVPDSERVIPPRTTTPYFL 342
>gi|183603931 protein phosphatase 6, catalytic subunit isoform c
[Homo sapiens]
Length = 283
Score = 328 bits (842), Expect = 3e-90
Identities = 161/301 (53%), Positives = 198/301 (65%), Gaps = 22/301 (7%)
Query: 9 ELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMEL 68
+LD++VE CK L EN ++ LC+ ++L +ESNVQ V PVTVCGD+HGQ
Sbjct: 5 DLDKYVEIARLCKYLPENDLKRLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQ------- 57
Query: 69 FRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYG 128
GD+VDRGYYS+ET T L+ALK ++P+RIT+LRGNHESRQITQVYG
Sbjct: 58 ---------------GDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYG 102
Query: 129 FYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQE 188
FYDEC KYGNAN W+Y T +FD L + AL+D QI C+HGGLSP I TLD IR ++R QE
Sbjct: 103 FYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQE 162
Query: 189 VPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGY 248
+PH+G CDL+WSDP+D W ISPRGAG+ FG ++ F H N L L+ RAHQLV EGY
Sbjct: 163 IPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGY 222
Query: 249 NWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYF 308
+ D +VT++SAPNYCYRCGN A+IM D F P R T YF
Sbjct: 223 KFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFRAVPDSERVIPPRTTTPYF 282
Query: 309 L 309
L
Sbjct: 283 L 283
>gi|4506007 protein phosphatase 1, catalytic subunit, gamma isoform
[Homo sapiens]
Length = 323
Score = 303 bits (775), Expect = 2e-82
Identities = 141/282 (50%), Positives = 197/282 (69%), Gaps = 3/282 (1%)
Query: 22 QLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYL 81
QL EN++R LC K++EI + + E+ P+ +CGD+HGQ++DL+ LF GG P++NYL
Sbjct: 29 QLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYL 88
Query: 82 FMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNAN 141
F+GDYVDRG S+ET+ LL+A K++YPE +LRGNHE I ++YGFYDEC R+Y N
Sbjct: 89 FLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRY-NIK 147
Query: 142 VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWS 201
+WK FTD F+ LP+ A+VD +IFC HGGLSP + +++ IR + R +VP +G +CDLLWS
Sbjct: 148 LWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWS 207
Query: 202 DPD-DRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIF 260
DPD D GWG + RG +TFG ++ F H + L L+ RAHQ+V +GY + R +VT+F
Sbjct: 208 DPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLF 267
Query: 261 SAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTR 302
SAPNYC N A+M +D+TL SF PA ++ +P+ TR
Sbjct: 268 SAPNYCGEFDNAGAMMSVDETLMCSFQILKPAEKK-KPNATR 308
>gi|56790945 protein phosphatase 1, catalytic subunit, alpha isoform
3 [Homo sapiens]
Length = 341
Score = 300 bits (768), Expect = 1e-81
Identities = 138/274 (50%), Positives = 191/274 (69%), Gaps = 2/274 (0%)
Query: 22 QLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYL 81
QL EN++R LC K++EI + + E+ P+ +CGD+HGQ++DL+ LF GG P++NYL
Sbjct: 40 QLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYL 99
Query: 82 FMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNAN 141
F+GDYVDRG S+ET+ LL+A K++YPE +LRGNHE I ++YGFYDEC R+Y N
Sbjct: 100 FLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRY-NIK 158
Query: 142 VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWS 201
+WK FTD F+ LP+ A+VD +IFC HGGLSP + +++ IR + R +VP +G +CDLLWS
Sbjct: 159 LWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWS 218
Query: 202 DPD-DRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIF 260
DPD D GWG + RG +TFG ++ F H + L L+ RAHQ+V +GY + R +VT+F
Sbjct: 219 DPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLF 278
Query: 261 SAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPR 294
SAPNYC N A+M +D+TL SF PA +
Sbjct: 279 SAPNYCGEFDNAGAMMSVDETLMCSFQILKPADK 312
>gi|4506003 protein phosphatase 1, catalytic subunit, alpha isoform
1 [Homo sapiens]
Length = 330
Score = 300 bits (768), Expect = 1e-81
Identities = 138/274 (50%), Positives = 191/274 (69%), Gaps = 2/274 (0%)
Query: 22 QLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYL 81
QL EN++R LC K++EI + + E+ P+ +CGD+HGQ++DL+ LF GG P++NYL
Sbjct: 29 QLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYL 88
Query: 82 FMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNAN 141
F+GDYVDRG S+ET+ LL+A K++YPE +LRGNHE I ++YGFYDEC R+Y N
Sbjct: 89 FLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRY-NIK 147
Query: 142 VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWS 201
+WK FTD F+ LP+ A+VD +IFC HGGLSP + +++ IR + R +VP +G +CDLLWS
Sbjct: 148 LWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWS 207
Query: 202 DPD-DRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIF 260
DPD D GWG + RG +TFG ++ F H + L L+ RAHQ+V +GY + R +VT+F
Sbjct: 208 DPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLF 267
Query: 261 SAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPR 294
SAPNYC N A+M +D+TL SF PA +
Sbjct: 268 SAPNYCGEFDNAGAMMSVDETLMCSFQILKPADK 301
>gi|46249376 protein phosphatase 1, catalytic subunit, beta isoform
1 [Homo sapiens]
Length = 327
Score = 290 bits (741), Expect = 1e-78
Identities = 134/277 (48%), Positives = 188/277 (67%), Gaps = 2/277 (0%)
Query: 22 QLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYL 81
Q+ E +VR LC K++EI + + E+ P+ +CGD+HGQ+ DL+ LF GG P+ NYL
Sbjct: 28 QMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYL 87
Query: 82 FMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNAN 141
F+GDYVDRG S+ET+ LL+A K++YPE +LRGNHE I ++YGFYDEC R++ N
Sbjct: 88 FLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRF-NIK 146
Query: 142 VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWS 201
+WK FTD F+ LP+ A+VD +IFC HGGLSP + +++ IR + R +VP G +CDLLWS
Sbjct: 147 LWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWS 206
Query: 202 DPD-DRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIF 260
DPD D GWG + RG +TFG D+ F + + L L+ RAHQ+V +GY + R +VT+F
Sbjct: 207 DPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLF 266
Query: 261 SAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGE 297
SAPNYC N +M +D+TL SF P+ ++ +
Sbjct: 267 SAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKKAK 303
>gi|4506005 protein phosphatase 1, catalytic subunit, beta isoform 1
[Homo sapiens]
Length = 327
Score = 290 bits (741), Expect = 1e-78
Identities = 134/277 (48%), Positives = 188/277 (67%), Gaps = 2/277 (0%)
Query: 22 QLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYL 81
Q+ E +VR LC K++EI + + E+ P+ +CGD+HGQ+ DL+ LF GG P+ NYL
Sbjct: 28 QMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYL 87
Query: 82 FMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNAN 141
F+GDYVDRG S+ET+ LL+A K++YPE +LRGNHE I ++YGFYDEC R++ N
Sbjct: 88 FLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRF-NIK 146
Query: 142 VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWS 201
+WK FTD F+ LP+ A+VD +IFC HGGLSP + +++ IR + R +VP G +CDLLWS
Sbjct: 147 LWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWS 206
Query: 202 DPD-DRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIF 260
DPD D GWG + RG +TFG D+ F + + L L+ RAHQ+V +GY + R +VT+F
Sbjct: 207 DPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLF 266
Query: 261 SAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGE 297
SAPNYC N +M +D+TL SF P+ ++ +
Sbjct: 267 SAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKKAK 303
>gi|239752750 PREDICTED: similar to protein phosphatase 2, catalytic
subunit, alpha [Homo sapiens]
Length = 384
Score = 273 bits (699), Expect = 1e-73
Identities = 143/255 (56%), Positives = 166/255 (65%), Gaps = 55/255 (21%)
Query: 23 LNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLF 82
L +V++LC++AKEILT+ESN QEV CPVTV GD HGQ
Sbjct: 172 LGSRKVKSLCKEAKEILTEESNAQEVWCPVTVSGDKHGQ--------------------- 210
Query: 83 MGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNANV 142
GDY+DRGYYS+E V LL+A+KV Y E +TIL NHESRQITQVY Y+ECLRK+GNAN
Sbjct: 211 -GDYIDRGYYSIEIVMLLLAVKVSYHECVTILPRNHESRQITQVYHSYEECLRKHGNAN- 268
Query: 143 WKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSD 202
DGQ+FCLHGGLSPS+DTL HIR L+ LQ++PHEGPM DLL+SD
Sbjct: 269 ----------------GDGQLFCLHGGLSPSVDTLHHIRTLNCLQKIPHEGPMGDLLYSD 312
Query: 203 PDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSA 262
PDD D ETFNHA+GL LVSRAHQLVM G+NWCHD NVV IFS
Sbjct: 313 PDD----------------HDTPETFNHASGLRLVSRAHQLVMVGHNWCHDWNVVAIFST 356
Query: 263 PNYCYRCGNQAAIME 277
PNYCY CG A ++
Sbjct: 357 PNYCYHCGGMALALQ 371
>gi|239747318 PREDICTED: similar to protein phosphatase 2, catalytic
subunit, alpha [Homo sapiens]
Length = 254
Score = 271 bits (693), Expect = 5e-73
Identities = 142/248 (57%), Positives = 163/248 (65%), Gaps = 55/248 (22%)
Query: 23 LNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLF 82
L +V++LC++AKEILT+ESN QEV CPVTV GD HGQ
Sbjct: 51 LGSRKVKSLCKEAKEILTEESNAQEVWCPVTVSGDKHGQ--------------------- 89
Query: 83 MGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNANV 142
GDY+DRGYYS+E V LL+A+KV Y E +TIL NHESRQITQVY Y+ECLRK+GNAN
Sbjct: 90 -GDYIDRGYYSIEIVMLLLAVKVSYHECVTILPRNHESRQITQVYHSYEECLRKHGNAN- 147
Query: 143 WKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSD 202
DGQ+FCLHGGLSPS+DTL HIR L+ LQ++PHEGPM DLL+SD
Sbjct: 148 ----------------GDGQLFCLHGGLSPSVDTLHHIRTLNCLQKIPHEGPMGDLLYSD 191
Query: 203 PDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSA 262
PDD D ETFNHA+GL LVSRAHQLVM G+NWCHD NVV IFS
Sbjct: 192 PDD----------------HDTPETFNHASGLRLVSRAHQLVMVGHNWCHDWNVVAIFST 235
Query: 263 PNYCYRCG 270
PNYCY CG
Sbjct: 236 PNYCYHCG 243
>gi|239741140 PREDICTED: similar to protein phosphatase 2, catalytic
subunit, alpha [Homo sapiens]
Length = 254
Score = 271 bits (693), Expect = 5e-73
Identities = 142/248 (57%), Positives = 163/248 (65%), Gaps = 55/248 (22%)
Query: 23 LNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLF 82
L +V++LC++AKEILT+ESN QEV CPVTV GD HGQ
Sbjct: 51 LGSRKVKSLCKEAKEILTEESNAQEVWCPVTVSGDKHGQ--------------------- 89
Query: 83 MGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNANV 142
GDY+DRGYYS+E V LL+A+KV Y E +TIL NHESRQITQVY Y+ECLRK+GNAN
Sbjct: 90 -GDYIDRGYYSIEIVMLLLAVKVSYHECVTILPRNHESRQITQVYHSYEECLRKHGNAN- 147
Query: 143 WKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSD 202
DGQ+FCLHGGLSPS+DTL HIR L+ LQ++PHEGPM DLL+SD
Sbjct: 148 ----------------GDGQLFCLHGGLSPSVDTLHHIRTLNCLQKIPHEGPMGDLLYSD 191
Query: 203 PDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSA 262
PDD D ETFNHA+GL LVSRAHQLVM G+NWCHD NVV IFS
Sbjct: 192 PDD----------------HDTPETFNHASGLRLVSRAHQLVMVGHNWCHDWNVVAIFST 235
Query: 263 PNYCYRCG 270
PNYCY CG
Sbjct: 236 PNYCYHCG 243
>gi|45827798 protein phosphatase 1, catalytic subunit, alpha isoform
2 [Homo sapiens]
Length = 286
Score = 271 bits (692), Expect = 7e-73
Identities = 125/240 (52%), Positives = 169/240 (70%), Gaps = 2/240 (0%)
Query: 56 GDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILR 115
GD+HGQ++DL+ LF GG P++NYLF+GDYVDRG S+ET+ LL+A K++YPE +LR
Sbjct: 19 GDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLR 78
Query: 116 GNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSID 175
GNHE I ++YGFYDEC R+Y N +WK FTD F+ LP+ A+VD +IFC HGGLSP +
Sbjct: 79 GNHECASINRIYGFYDECKRRY-NIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQ 137
Query: 176 TLDHIRALDRLQEVPHEGPMCDLLWSDPD-DRGGWGISPRGAGYTFGQDISETFNHANGL 234
+++ IR + R +VP +G +CDLLWSDPD D GWG + RG +TFG ++ F H + L
Sbjct: 138 SMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDL 197
Query: 235 TLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPR 294
L+ RAHQ+V +GY + R +VT+FSAPNYC N A+M +D+TL SF PA +
Sbjct: 198 DLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADK 257
>gi|5453958 protein phosphatase 5, catalytic subunit [Homo sapiens]
Length = 499
Score = 235 bits (599), Expect = 4e-62
Identities = 122/296 (41%), Positives = 180/296 (60%), Gaps = 11/296 (3%)
Query: 5 AFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCP----VTVCGDVHG 60
+F KEL QW + + K+L+ + + KE+L+K S + E +TVCGD HG
Sbjct: 189 SFMKELMQWYK---DQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVCGDTHG 245
Query: 61 QFHDLMELFRIGGKSPDTN-YLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHE 119
QF+DL+ +F + G +TN Y+F GD+VDRG +SVE + L K+ YP+ +LRGNHE
Sbjct: 246 QFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHE 305
Query: 120 SRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGL-SPSIDTLD 178
+ + Q+YGF E KY A +++ F+++F++LPL ++G++ +HGGL S TLD
Sbjct: 306 TDNMNQIYGFEGEVKAKY-TAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLD 364
Query: 179 HIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVS 238
IR ++R ++ P GPMCDLLWSDP + G IS RG FG D+++ F N L +
Sbjct: 365 DIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNLDYII 424
Query: 239 RAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDT-LKYSFLQFDPAP 293
R+H++ EGY H VT+FSAPNYC + GN+A+ + L + L+ F QF P
Sbjct: 425 RSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVP 480
>gi|194688147 protein phosphatase 3, catalytic subunit, alpha
isoform isoform 2 [Homo sapiens]
Length = 511
Score = 227 bits (578), Expect = 1e-59
Identities = 123/286 (43%), Positives = 171/286 (59%), Gaps = 16/286 (5%)
Query: 22 QLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYL 81
+L E+ + + IL +E N+ ++ PVTVCGD+HGQF DLM+LF +GG +T YL
Sbjct: 55 RLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYL 114
Query: 82 FMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNAN 141
F+GDYVDRGY+S+E V L ALK+ YP+ + +LRGNHE R +T+ + F EC KY +
Sbjct: 115 FLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKY-SER 173
Query: 142 VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWS 201
V+ D FD LPL AL++ Q C+HGGLSP I+TLD IR LDR +E P GPMCD+LWS
Sbjct: 174 VYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWS 233
Query: 202 DP-DDRGGWGI-------SPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHD 253
DP +D G + RG Y + F N L + RAH+ GY
Sbjct: 234 DPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRK 293
Query: 254 R------NVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP 293
+++TIFSAPNY N+AA+++ ++ + + QF+ +P
Sbjct: 294 SQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNV-MNIRQFNCSP 338
>gi|6715568 protein phosphatase 3, catalytic subunit, alpha isoform
isoform 1 [Homo sapiens]
Length = 521
Score = 227 bits (578), Expect = 1e-59
Identities = 123/286 (43%), Positives = 171/286 (59%), Gaps = 16/286 (5%)
Query: 22 QLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYL 81
+L E+ + + IL +E N+ ++ PVTVCGD+HGQF DLM+LF +GG +T YL
Sbjct: 55 RLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYL 114
Query: 82 FMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNAN 141
F+GDYVDRGY+S+E V L ALK+ YP+ + +LRGNHE R +T+ + F EC KY +
Sbjct: 115 FLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKY-SER 173
Query: 142 VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWS 201
V+ D FD LPL AL++ Q C+HGGLSP I+TLD IR LDR +E P GPMCD+LWS
Sbjct: 174 VYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWS 233
Query: 202 DP-DDRGGWGI-------SPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHD 253
DP +D G + RG Y + F N L + RAH+ GY
Sbjct: 234 DPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRK 293
Query: 254 R------NVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP 293
+++TIFSAPNY N+AA+++ ++ + + QF+ +P
Sbjct: 294 SQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNV-MNIRQFNCSP 338
>gi|215272354 protein phosphatase 3, catalytic subunit, beta isoform
c [Homo sapiens]
Length = 515
Score = 223 bits (569), Expect = 1e-58
Identities = 121/286 (42%), Positives = 167/286 (58%), Gaps = 16/286 (5%)
Query: 22 QLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYL 81
+++E + + IL +E + EV P+TVCGD+HGQF DLM+LF +GG +T YL
Sbjct: 64 RVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYL 123
Query: 82 FMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNAN 141
F+GDYVDRGY+S+E V L LK+ YP + +LRGNHE R +T+ + F EC KY +
Sbjct: 124 FLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKY-SER 182
Query: 142 VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWS 201
V++ + FD LPL AL++ Q C+HGGLSP I TLD IR LDR +E P GPMCDLLWS
Sbjct: 183 VYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWS 242
Query: 202 DPDDRGGWGISP--------RGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHD 253
DP + G S RG Y + F N L + RAH+ GY
Sbjct: 243 DPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRK 302
Query: 254 R------NVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP 293
+++TIFSAPNY N+AA+++ ++ + + QF+ +P
Sbjct: 303 SQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNV-MNIRQFNCSP 347
>gi|215272352 protein phosphatase 3, catalytic subunit, beta isoform
a [Homo sapiens]
Length = 525
Score = 223 bits (569), Expect = 1e-58
Identities = 121/286 (42%), Positives = 167/286 (58%), Gaps = 16/286 (5%)
Query: 22 QLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYL 81
+++E + + IL +E + EV P+TVCGD+HGQF DLM+LF +GG +T YL
Sbjct: 64 RVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYL 123
Query: 82 FMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNAN 141
F+GDYVDRGY+S+E V L LK+ YP + +LRGNHE R +T+ + F EC KY +
Sbjct: 124 FLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKY-SER 182
Query: 142 VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWS 201
V++ + FD LPL AL++ Q C+HGGLSP I TLD IR LDR +E P GPMCDLLWS
Sbjct: 183 VYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWS 242
Query: 202 DPDDRGGWGISP--------RGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHD 253
DP + G S RG Y + F N L + RAH+ GY
Sbjct: 243 DPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRK 302
Query: 254 R------NVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP 293
+++TIFSAPNY N+AA+++ ++ + + QF+ +P
Sbjct: 303 SQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNV-MNIRQFNCSP 347
>gi|11036640 protein phosphatase 3, catalytic subunit, beta isoform
b [Homo sapiens]
Length = 524
Score = 223 bits (569), Expect = 1e-58
Identities = 121/286 (42%), Positives = 167/286 (58%), Gaps = 16/286 (5%)
Query: 22 QLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYL 81
+++E + + IL +E + EV P+TVCGD+HGQF DLM+LF +GG +T YL
Sbjct: 64 RVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYL 123
Query: 82 FMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNAN 141
F+GDYVDRGY+S+E V L LK+ YP + +LRGNHE R +T+ + F EC KY +
Sbjct: 124 FLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKY-SER 182
Query: 142 VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWS 201
V++ + FD LPL AL++ Q C+HGGLSP I TLD IR LDR +E P GPMCDLLWS
Sbjct: 183 VYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWS 242
Query: 202 DPDDRGGWGISP--------RGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHD 253
DP + G S RG Y + F N L + RAH+ GY
Sbjct: 243 DPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRK 302
Query: 254 R------NVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP 293
+++TIFSAPNY N+AA+++ ++ + + QF+ +P
Sbjct: 303 SQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNV-MNIRQFNCSP 347
>gi|194688149 protein phosphatase 3, catalytic subunit, alpha
isoform isoform 3 [Homo sapiens]
Length = 469
Score = 220 bits (560), Expect = 1e-57
Identities = 117/258 (45%), Positives = 155/258 (60%), Gaps = 15/258 (5%)
Query: 22 QLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYL 81
+L E+ + + IL +E N+ ++ PVTVCGD+HGQF DLM+LF +GG +T YL
Sbjct: 55 RLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYL 114
Query: 82 FMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNAN 141
F+GDYVDRGY+S+E V L ALK+ YP+ + +LRGNHE R +T+ + F EC KY +
Sbjct: 115 FLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKY-SER 173
Query: 142 VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWS 201
V+ D FD LPL AL++ Q C+HGGLSP I+TLD IR LDR +E P GPMCD+LWS
Sbjct: 174 VYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWS 233
Query: 202 DP-DDRGGWGI-------SPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHD 253
DP +D G + RG Y + F N L + RAH+ GY
Sbjct: 234 DPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRK 293
Query: 254 R------NVVTIFSAPNY 265
+++TIFSAPNY
Sbjct: 294 SQTTGFPSLITIFSAPNY 311
>gi|21361290 protein phosphatase 3, catalytic subunit, gamma [Homo
sapiens]
Length = 512
Score = 215 bits (548), Expect = 3e-56
Identities = 117/286 (40%), Positives = 164/286 (57%), Gaps = 16/286 (5%)
Query: 22 QLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYL 81
+L E + IL +E + EV P+TVCGD+HGQF DLM+LF +GG +T YL
Sbjct: 51 RLEEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYL 110
Query: 82 FMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNAN 141
F+GDYVDRGY+S+E V L +LK+ +P+ + +LRGNHE R +T + F EC KY +
Sbjct: 111 FLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKY-SEQ 169
Query: 142 VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWS 201
V+ + FD LPL AL++ Q C+HGG+SP I +LD IR LDR E P GP+CDLLWS
Sbjct: 170 VYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWS 229
Query: 202 DPDDRGG--------WGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHD 253
DP + G + RG Y + F N L + RAH+ GY
Sbjct: 230 DPSEDYGNEKTLEHYTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRK 289
Query: 254 R------NVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP 293
+++TIFSAPNY N+AA+++ ++ + + QF+ +P
Sbjct: 290 SQATGFPSLITIFSAPNYLDVYNNKAAVLKYENNV-MNIRQFNCSP 334
>gi|23312374 protein phosphatase with EF hand calcium-binding domain
1 isoform 1b [Homo sapiens]
Length = 625
Score = 148 bits (373), Expect = 7e-36
Identities = 99/306 (32%), Positives = 154/306 (50%), Gaps = 27/306 (8%)
Query: 9 ELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCP----VTVCGDVHGQFHD 64
++D +E E + L+ + V + + K++L + N ++ VT+CGD+HG+ D
Sbjct: 120 DIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHIQTSPSKEVTICGDLHGKLDD 179
Query: 65 LMELFRIGGKSPDTN-YLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQI 123
L +F G + N Y+F GD+VDRG S+E + +L + YP + + RGNHE +
Sbjct: 180 LFLIFYKNGLPSERNPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMM 239
Query: 124 TQVYGFYDECLRKYG--NANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSID-TLDHI 180
YGF E L KY + + + + +LP+ +VD +I +HGG+S + D L H
Sbjct: 240 NLRYGFTKEILHKYKLHGKRILQILEEFYAWLPIGTIVDNEILVIHGGISETTDLNLLHR 299
Query: 181 RALDRLQEV---PHE-----------GPMCDLLWSDPDDRGGWGISP---RGAGYTFGQD 223
++++ V P E + D+LWSDP RG G P RG G FG D
Sbjct: 300 VERNKMKSVLIPPTETNRDHDTDSKHNKIIDILWSDP--RGKNGCFPNTCRGGGCYFGPD 357
Query: 224 ISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLK 283
++ + L ++ R+H+ EGY CHD VVTIFSA NY N+ A ++L
Sbjct: 358 VTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYIKLCSGTT 417
Query: 284 YSFLQF 289
F Q+
Sbjct: 418 PRFFQY 423
>gi|23312380 protein phosphatase with EF hand calcium-binding domain
1 isoform 1 [Homo sapiens]
Length = 653
Score = 137 bits (345), Expect = 1e-32
Identities = 99/334 (29%), Positives = 154/334 (46%), Gaps = 55/334 (16%)
Query: 9 ELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCP----VTVCGDVHGQFHD 64
++D +E E + L+ + V + + K++L + N ++ VT+CGD+HG+ D
Sbjct: 120 DIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHIQTSPSKEVTICGDLHGKLDD 179
Query: 65 LMELFRIGGKSPDTN-YLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQI 123
L +F G + N Y+F GD+VDRG S+E + +L + YP + + RGNHE +
Sbjct: 180 LFLIFYKNGLPSERNPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMM 239
Query: 124 TQVYGFYDECLRKY--GNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSID-TLDHI 180
YGF E L KY + + + + +LP+ +VD +I +HGG+S + D L H
Sbjct: 240 NLRYGFTKEILHKYKLHGKRILQILEEFYAWLPIGTIVDNEILVIHGGISETTDLNLLHR 299
Query: 181 RALDRLQEV-----------------------------------------PHE-GPMCDL 198
++++ V HE + D+
Sbjct: 300 VERNKMKSVLIPPTETNRDHDTDSKHNKVGVTFNAHGRIKTNGSPTEHLTEHEWEQIIDI 359
Query: 199 LWSDPDDRGGWGISP---RGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRN 255
LWSDP RG G P RG G FG D++ + L ++ R+H+ EGY CHD
Sbjct: 360 LWSDP--RGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGK 417
Query: 256 VVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQF 289
VVTIFSA NY N+ A ++L F Q+
Sbjct: 418 VVTIFSASNYYEEGSNRGAYIKLCSGTTPRFFQY 451
>gi|23312386 serine/threonine protein phosphatase with EF-hand
motifs 2 [Homo sapiens]
Length = 753
Score = 110 bits (276), Expect = 1e-24
Identities = 65/181 (35%), Positives = 98/181 (54%), Gaps = 11/181 (6%)
Query: 14 VEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRC----PVTVCGDVHGQFHDLMELF 69
VE +QL+ V L + K+ L + N+ V +TVCGD+HGQ DL+ +F
Sbjct: 132 VEAFRLKQQLHARYVLNLLYETKKHLVQLPNINRVSTCYSEEITVCGDLHGQLDDLIFIF 191
Query: 70 RIGG-KSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYG 128
G SP+ +Y+F GD+VDRG SVE + +L A + YP+ + RGNHE + YG
Sbjct: 192 YKNGLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYG 251
Query: 129 FYDECLRKY--GNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRL 186
F E + KY + + D+F +LPL L+D ++ LHGG+S D + LD++
Sbjct: 252 FTKEVMNKYKVHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDITD----LELLDKI 307
Query: 187 Q 187
+
Sbjct: 308 E 308
Score = 65.1 bits (157), Expect = 8e-11
Identities = 34/94 (36%), Positives = 52/94 (55%), Gaps = 1/94 (1%)
Query: 197 DLLWSDPDDRGGWGISP-RGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRN 255
D+LWSDP + G + RG G FG D+++ + + R+H+ EGY +CH+R
Sbjct: 443 DILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRK 502
Query: 256 VVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQF 289
V+TIFSA NY N+ A ++L L +Q+
Sbjct: 503 VLTIFSASNYYEVGSNRGAYVKLGPALTPHIVQY 536
>gi|23312378 protein phosphatase with EF hand calcium-binding domain
1 isoform 3 [Homo sapiens]
Length = 591
Score = 103 bits (258), Expect = 1e-22
Identities = 81/288 (28%), Positives = 132/288 (45%), Gaps = 25/288 (8%)
Query: 9 ELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCP----VTVCGDVHGQFHD 64
++D +E E + L+ + V + + K++L + N ++ VT+CGD+HG+ D
Sbjct: 120 DIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHIQTSPSKEVTICGDLHGKLDD 179
Query: 65 LMELFRIGGKSPDTN-YLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQI 123
L +F G + N Y+F GD+VDRG S+E + +L + YP + + RGNHE +
Sbjct: 180 LFLIFYKNGLPSERNPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMM 239
Query: 124 TQVYGFYDECLRKY--GNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIR 181
YGF E L KY + + + + +LP+ +VD +I +HGG+S + D
Sbjct: 240 NLRYGFTKEILHKYKLHGKRILQILEEFYAWLPIGTIVDNEILVIHGGISETTD------ 293
Query: 182 ALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAH 241
L+ L V L+ +R S + TFN A+G + +
Sbjct: 294 -LNLLHRVERNKMKSVLIPPTETNRDHDTDSKH-------NKVGVTFN-AHGRIKTNGSP 344
Query: 242 QLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQF 289
+ + W VVTIFSA NY N+ A ++L F Q+
Sbjct: 345 TEHLTEHEW---EQVVTIFSASNYYEEGSNRGAYIKLCSGTTPRFFQY 389
>gi|169217489 PREDICTED: similar to phosphodiesterase 4D
interacting protein [Homo sapiens]
Length = 211
Score = 29.3 bits (64), Expect = 4.6
Identities = 20/77 (25%), Positives = 39/77 (50%), Gaps = 1/77 (1%)
Query: 8 KELDQWVEQLNECKQLNENQVRTL-CEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLM 66
+EL + ++QL E Q Q+R EK EI T+E N+Q + ++ + +F +L+
Sbjct: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
Query: 67 ELFRIGGKSPDTNYLFM 83
+ K+ + N + +
Sbjct: 62 QYRDNSDKTLEANEMLL 78
>gi|29789379 sphingomyelin synthase 1 [Homo sapiens]
Length = 413
Score = 29.3 bits (64), Expect = 4.6
Identities = 19/62 (30%), Positives = 30/62 (48%), Gaps = 1/62 (1%)
Query: 50 CPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPE 109
C + GD Q +M+L GG S ++ GDY+ G+ + T+T L +K P
Sbjct: 244 CSPKLFGDWEAQLRRIMKLIAGGGLSITGSHNMCGDYLYSGHTVMLTLTYLF-IKEYSPR 302
Query: 110 RI 111
R+
Sbjct: 303 RL 304
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.140 0.448
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,593,302
Number of Sequences: 37866
Number of extensions: 560184
Number of successful extensions: 1358
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 29
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 1268
Number of HSP's gapped (non-prelim): 37
length of query: 309
length of database: 18,247,518
effective HSP length: 102
effective length of query: 207
effective length of database: 14,385,186
effective search space: 2977733502
effective search space used: 2977733502
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.