Guide to the Human Genome
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Search of human proteins with 47132583

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|47132583 cAMP-dependent protein kinase, regulatory subunit
alpha 1 [Homo sapiens]
         (381 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|47132583 cAMP-dependent protein kinase, regulatory subunit al...   750   0.0  
gi|47132581 cAMP-dependent protein kinase, regulatory subunit al...   750   0.0  
gi|4506063 cAMP-dependent protein kinase, regulatory subunit alp...   750   0.0  
gi|38257139 protein kinase, cAMP-dependent, regulatory, type I, ...   630   0.0  
gi|4758958 cAMP-dependent protein kinase, regulatory subunit alp...   237   1e-62
gi|47132585 cAMP-dependent protein kinase, regulatory subunit be...   234   1e-61
gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Ho...   167   1e-41
gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [H...   163   3e-40
gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]     147   2e-35
gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b ...    54   2e-07
gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [...    54   2e-07
gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a ...    54   2e-07
gi|148727335 patatin-like phospholipase domain containing 7 isof...    54   2e-07
gi|148727290 patatin-like phospholipase domain containing 7 isof...    54   2e-07
gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof...    54   3e-07
gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof...    54   3e-07
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p...    52   7e-07
gi|156071470 hyperpolarization activated cyclic nucleotide-gated...    49   6e-06
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ...    49   6e-06
gi|116325989 hyperpolarization activated cyclic nucleotide-gated...    49   1e-05
gi|116256487 patatin-like phospholipase domain containing 6 [Hom...    48   1e-05
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]     42   0.001
gi|18201890 hypothetical protein LOC140894 [Homo sapiens]              40   0.005
gi|123173766 tubulin polyglutamylase complex subunit 1 [Homo sap...    39   0.008
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]     39   0.010
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [...    38   0.013
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho...    38   0.013
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H...    36   0.050
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [...    36   0.066
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H...    36   0.066

>gi|47132583 cAMP-dependent protein kinase, regulatory subunit alpha
           1 [Homo sapiens]
          Length = 381

 Score =  750 bits (1936), Expect = 0.0
 Identities = 381/381 (100%), Positives = 381/381 (100%)

Query: 1   MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 60
           MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE
Sbjct: 1   MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 60

Query: 61  EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 120
           EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK
Sbjct: 61  EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 120

Query: 121 DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG 180
           DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG
Sbjct: 121 DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG 180

Query: 181 ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 240
           ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL
Sbjct: 181 ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 240

Query: 241 RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA 300
           RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA
Sbjct: 241 RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA 300

Query: 301 AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG 360
           AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG
Sbjct: 301 AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG 360

Query: 361 PCSDILKRNIQQYNSFVSLSV 381
           PCSDILKRNIQQYNSFVSLSV
Sbjct: 361 PCSDILKRNIQQYNSFVSLSV 381


>gi|47132581 cAMP-dependent protein kinase, regulatory subunit alpha
           1 [Homo sapiens]
          Length = 381

 Score =  750 bits (1936), Expect = 0.0
 Identities = 381/381 (100%), Positives = 381/381 (100%)

Query: 1   MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 60
           MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE
Sbjct: 1   MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 60

Query: 61  EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 120
           EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK
Sbjct: 61  EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 120

Query: 121 DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG 180
           DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG
Sbjct: 121 DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG 180

Query: 181 ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 240
           ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL
Sbjct: 181 ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 240

Query: 241 RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA 300
           RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA
Sbjct: 241 RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA 300

Query: 301 AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG 360
           AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG
Sbjct: 301 AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG 360

Query: 361 PCSDILKRNIQQYNSFVSLSV 381
           PCSDILKRNIQQYNSFVSLSV
Sbjct: 361 PCSDILKRNIQQYNSFVSLSV 381


>gi|4506063 cAMP-dependent protein kinase, regulatory subunit alpha
           1 [Homo sapiens]
          Length = 381

 Score =  750 bits (1936), Expect = 0.0
 Identities = 381/381 (100%), Positives = 381/381 (100%)

Query: 1   MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 60
           MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE
Sbjct: 1   MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 60

Query: 61  EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 120
           EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK
Sbjct: 61  EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 120

Query: 121 DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG 180
           DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG
Sbjct: 121 DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG 180

Query: 181 ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 240
           ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL
Sbjct: 181 ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 240

Query: 241 RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA 300
           RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA
Sbjct: 241 RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA 300

Query: 301 AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG 360
           AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG
Sbjct: 301 AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG 360

Query: 361 PCSDILKRNIQQYNSFVSLSV 381
           PCSDILKRNIQQYNSFVSLSV
Sbjct: 361 PCSDILKRNIQQYNSFVSLSV 381


>gi|38257139 protein kinase, cAMP-dependent, regulatory, type I,
           beta [Homo sapiens]
          Length = 381

 Score =  630 bits (1625), Expect = 0.0
 Identities = 310/381 (81%), Positives = 345/381 (90%)

Query: 1   MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 60
           M S     SEE  SL+ CELYVQ H IQ +LKD IV LC ++PERPM FLRE+FE+LEKE
Sbjct: 1   MASPPACPSEEDESLKGCELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKE 60

Query: 61  EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 120
           E +QI   QK+ +++DS ++E+SP PPNPVVK RRRRG +SAEVYTEEDA SYVRKVIPK
Sbjct: 61  ENRQILARQKSNSQSDSHDEEVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPK 120

Query: 121 DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG 180
           DYKTM ALAKAI KNVLF+HLDDNERSDIFDAMF V+ IAGETVIQQG+EGDNFYV+DQG
Sbjct: 121 DYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQG 180

Query: 181 ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 240
           E DVYVN EW T++ EGGSFGELALIYGTPRAATVKAKT++KLWGIDRDSYRRILMGSTL
Sbjct: 181 EVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTL 240

Query: 241 RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA 300
           RKRKMYEEFLSKVSILESL+KWERLTVADALEPVQFEDG+KIVVQGEPGD+F+II EG+A
Sbjct: 241 RKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTA 300

Query: 301 AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG 360
           +VLQRRS NEE+VEVGRLGPSDYFGEIALL+NRPRAATVVARGPLKCVKLDRPRFERVLG
Sbjct: 301 SVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFERVLG 360

Query: 361 PCSDILKRNIQQYNSFVSLSV 381
           PCS+ILKRNIQ+YNSF+SL+V
Sbjct: 361 PCSEILKRNIQRYNSFISLTV 381


>gi|4758958 cAMP-dependent protein kinase, regulatory subunit alpha
           2 [Homo sapiens]
          Length = 404

 Score =  237 bits (604), Expect = 1e-62
 Identities = 144/375 (38%), Positives = 209/375 (55%), Gaps = 33/375 (8%)

Query: 30  LLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPN- 88
           LL+   V++   +P   + F  EYF RL   EA+   ++  A T   S       P P+ 
Sbjct: 13  LLQGYTVEVLRQQPPDLVEFAVEYFTRLR--EARAPASVLPAATPRQSLGHPPPEPGPDR 70

Query: 89  ------------------PVVKGRRRRGAISAEVYT--EEDAASYVRKVIPKDYKTMAAL 128
                             PV     RR ++ AE Y   EE+  +  R + PK  +    L
Sbjct: 71  VADAKGDSESEEDEDLEVPVPSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRL 130

Query: 129 AKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNN 188
            +A +  +LF +LD  + S + DAMF     A E VI QGD+GDNFYVI++G  D+ V  
Sbjct: 131 QEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTK 190

Query: 189 EWAT-SVGE---GGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRK 244
           +  T SVG+    GSFGELAL+Y TPRAAT+ A +   LWG+DR ++RRI++ +  +KRK
Sbjct: 191 DNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRK 250

Query: 245 MYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQ 304
           M+E F+  V +L+SL+  ER+ + D +    ++DG++I+ QGE  D F+II  G  ++L 
Sbjct: 251 MFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILI 310

Query: 305 R------RSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERV 358
           R      +    + VE+ R     YFGE+AL+ N+PRAA+  A G +KC+ +D   FER+
Sbjct: 311 RSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERL 370

Query: 359 LGPCSDILKRNIQQY 373
           LGPC DI+KRNI  Y
Sbjct: 371 LGPCMDIMKRNISHY 385


>gi|47132585 cAMP-dependent protein kinase, regulatory subunit beta
           2 [Homo sapiens]
          Length = 418

 Score =  234 bits (596), Expect = 1e-61
 Identities = 134/315 (42%), Positives = 185/315 (58%), Gaps = 19/315 (6%)

Query: 76  DSREDEISPPPPN----PVVKGRRRRGAISAEVYT----EEDAASYVRKVIPKDYKTMAA 127
           D  E+E +P        PV+    RR ++ AE Y     E+DA S  R + PK       
Sbjct: 87  DGEEEEAAPADAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAES--RIIHPKTDDQRNR 144

Query: 128 LAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVN 187
           L +A +  +LF +LD  + S + DAMF      GE VI QGD+GDNFYVID+G  D+YV 
Sbjct: 145 LQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVK 204

Query: 188 ----NEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKR 243
                    +    GSFGELAL+Y TPRAAT+ A +   LWG+DR ++RRI++ +  +KR
Sbjct: 205 CDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKR 264

Query: 244 KMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVL 303
           KMYE F+  +  L+SL+  ERL V D +    + DG++I+ QG+  D FFI+  G   + 
Sbjct: 265 KMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKIT 324

Query: 304 QRR---SENEE--FVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERV 358
            +R   SE EE   VE+ R     YFGE+AL+ N+PRAA+  A G +KC+ +D   FER+
Sbjct: 325 MKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERL 384

Query: 359 LGPCSDILKRNIQQY 373
           LGPC +I+KRNI  Y
Sbjct: 385 LGPCMEIMKRNIATY 399


>gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Homo
           sapiens]
          Length = 686

 Score =  167 bits (424), Expect = 1e-41
 Identities = 107/361 (29%), Positives = 178/361 (49%), Gaps = 26/361 (7%)

Query: 7   AASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQ 66
           A  E+   LR+ +  + +  ++   KD ++Q      ++  + +R   ++ +K+ A  +Q
Sbjct: 10  ALQEKIEELRQRDALIDELELELDQKDELIQKLQNELDKYRSVIRPATQQAQKQSASTLQ 69

Query: 67  NLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAE--VYTEEDAASYVRKVIPKDYKT 124
                                    + R +R AISAE   +  +D +       PK  ++
Sbjct: 70  G------------------------EPRTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQS 105

Query: 125 MAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDV 184
              + +AI  N    +L+ ++  +I D M+ V +     +I++GD G   YV++ G+ +V
Sbjct: 106 KDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEV 165

Query: 185 YVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRK 244
                   ++G G  FGELA++Y   R ATVK   NVKLW IDR  ++ I+M + L K  
Sbjct: 166 TKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHT 225

Query: 245 MYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQ 304
            Y EFL  V   +SL +     +AD LE   +E+G+ I+ QG  GD FFII +G+  V +
Sbjct: 226 EYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTR 285

Query: 305 RRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSD 364
             S +E+ V +  LG  D+FGE AL     R A V+A   + C+ +DR  F+ ++G   D
Sbjct: 286 EDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDD 345

Query: 365 I 365
           +
Sbjct: 346 V 346



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 37/121 (30%), Positives = 58/121 (47%), Gaps = 6/121 (4%)

Query: 138 FSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNE------WA 191
           F  L +   S + D +    +  GE +I+QG  GD F++I +G  +V   +       + 
Sbjct: 237 FQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFL 296

Query: 192 TSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLS 251
            ++G+G  FGE AL     R A V A   V    IDRDS++ ++ G      K YE+  +
Sbjct: 297 RTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEA 356

Query: 252 K 252
           K
Sbjct: 357 K 357


>gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [Homo
           sapiens]
          Length = 671

 Score =  163 bits (412), Expect = 3e-40
 Identities = 109/338 (32%), Positives = 174/338 (51%), Gaps = 13/338 (3%)

Query: 31  LKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPV 90
           L++   ++   + ER    ++E  +RL ++E ++IQ L++   +  S    + P P   +
Sbjct: 4   LEEDFAKILMLKEER----IKELEKRLSEKE-EEIQELKRKLHKCQS----VLPVPSTHI 54

Query: 91  VKGRRRRGAISAEVYTEE---DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERS 147
                R   ISAE  T     D     RK   K  ++   + +AI  N    +L+ ++  
Sbjct: 55  GPRTTRAQGISAEPQTYRSFHDLRQAFRK-FTKSERSKDLIKEAILDNDFMKNLELSQIQ 113

Query: 148 DIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIY 207
           +I D M+ V +     +I++GD G   YV++ G+ +V        ++G G  FGELA++Y
Sbjct: 114 EIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILY 173

Query: 208 GTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTV 267
              R ATVK   NVKLW IDR  ++ I+M + L K   Y EFL  V   +SL +     +
Sbjct: 174 NCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKL 233

Query: 268 ADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEI 327
           AD LE   +E+G+ I+ QG  GD FFII +G+  V +  S +E+ V +  LG  D+FGE 
Sbjct: 234 ADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEK 293

Query: 328 ALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDI 365
           AL     R A V+A   + C+ +DR  F+ ++G   D+
Sbjct: 294 ALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDV 331



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 37/121 (30%), Positives = 58/121 (47%), Gaps = 6/121 (4%)

Query: 138 FSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNE------WA 191
           F  L +   S + D +    +  GE +I+QG  GD F++I +G  +V   +       + 
Sbjct: 222 FQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFL 281

Query: 192 TSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLS 251
            ++G+G  FGE AL     R A V A   V    IDRDS++ ++ G      K YE+  +
Sbjct: 282 RTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEA 341

Query: 252 K 252
           K
Sbjct: 342 K 342


>gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]
          Length = 762

 Score =  147 bits (370), Expect = 2e-35
 Identities = 83/282 (29%), Positives = 150/282 (53%), Gaps = 10/282 (3%)

Query: 96  RRGA---ISAEVYT------EEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNER 146
           RRGA   +SAE  T      +    S+ +  + KD      +  A+ KN     LD  + 
Sbjct: 118 RRGAKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQI 177

Query: 147 SDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALI 206
            D+ + M+  ++  G  +I+QG+ G++ +V+ +G  +V+   +  +S+    +FGELA++
Sbjct: 178 KDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAIL 237

Query: 207 YGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLT 266
           Y   R A+VKA TNVK W +DR+ ++ I+  +   + + Y  FL  VS+L++L + +   
Sbjct: 238 YNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTK 297

Query: 267 VADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGE 326
           + D LE   ++ G  I+ +GE G  FFI+ +G   V Q    +++   +  L   +YFGE
Sbjct: 298 IIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGE 357

Query: 327 IALLMNRPRAATVVA-RGPLKCVKLDRPRFERVLGPCSDILK 367
            AL+ +  R+A ++A    + C+ +DR  F + +G   ++ K
Sbjct: 358 KALISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQK 399



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 41/168 (24%), Positives = 82/168 (48%), Gaps = 12/168 (7%)

Query: 213 ATVKAKTNVKLWGIDRD---SYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVAD 269
           A V A+   + + +++    S+ +  +     ++K+  + L+K   L+ LD  +   + +
Sbjct: 123 AGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVE 182

Query: 270 ALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIAL 329
            +    ++ G  I+ QGEPG+  F++ EG   V Q     E+ +    +  +  FGE+A+
Sbjct: 183 CMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQ----GEKLLSSIPMWTT--FGELAI 236

Query: 330 LMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFV 377
           L N  R A+V A   +K   LDR  F+ ++   +   +   +QY +F+
Sbjct: 237 LYNCTRTASVKAITNVKTWALDREVFQNIMRRTA---QARDEQYRNFL 281


>gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b
           [Homo sapiens]
          Length = 881

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 35/122 (28%), Positives = 65/122 (53%), Gaps = 4/122 (3%)

Query: 139 SHLDDNERSDIFDAM-FSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEW-ATSVGE 196
           +HL ++ + ++   + F     AG  +  QGD+G ++Y+I +G  +V  + +   T++ E
Sbjct: 205 AHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHE 264

Query: 197 GGSFGELALIYGTPRAAT-VKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSI 255
           G  FG+LAL+   PRAAT +  + N     +D+  + RI+     +  ++ EE    V +
Sbjct: 265 GDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRL-EEHGKVVLV 323

Query: 256 LE 257
           LE
Sbjct: 324 LE 325



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 31/116 (26%), Positives = 56/116 (48%), Gaps = 6/116 (5%)

Query: 245 MYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQ 304
           ++EE L   ++    +  +R   A  L     + G  +  QG+ G  ++II +GS  V+ 
Sbjct: 194 IFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVT 253

Query: 305 RRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVAR-GPLKCVKLDRPRFERVL 359
                     V  L   D FG++AL+ + PRAAT++ R      +++D+  F R++
Sbjct: 254 HGKGL-----VTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRII 304


>gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b
           [Homo sapiens]
          Length = 881

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 35/122 (28%), Positives = 65/122 (53%), Gaps = 4/122 (3%)

Query: 139 SHLDDNERSDIFDAM-FSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEW-ATSVGE 196
           +HL ++ + ++   + F     AG  +  QGD+G ++Y+I +G  +V  + +   T++ E
Sbjct: 205 AHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHE 264

Query: 197 GGSFGELALIYGTPRAAT-VKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSI 255
           G  FG+LAL+   PRAAT +  + N     +D+  + RI+     +  ++ EE    V +
Sbjct: 265 GDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRL-EEHGKVVLV 323

Query: 256 LE 257
           LE
Sbjct: 324 LE 325



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 31/116 (26%), Positives = 56/116 (48%), Gaps = 6/116 (5%)

Query: 245 MYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQ 304
           ++EE L   ++    +  +R   A  L     + G  +  QG+ G  ++II +GS  V+ 
Sbjct: 194 IFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVT 253

Query: 305 RRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVAR-GPLKCVKLDRPRFERVL 359
                     V  L   D FG++AL+ + PRAAT++ R      +++D+  F R++
Sbjct: 254 HGKGL-----VTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRII 304


>gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a
           [Homo sapiens]
          Length = 923

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 35/122 (28%), Positives = 65/122 (53%), Gaps = 4/122 (3%)

Query: 139 SHLDDNERSDIFDAM-FSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEW-ATSVGE 196
           +HL ++ + ++   + F     AG  +  QGD+G ++Y+I +G  +V  + +   T++ E
Sbjct: 247 AHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHE 306

Query: 197 GGSFGELALIYGTPRAAT-VKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSI 255
           G  FG+LAL+   PRAAT +  + N     +D+  + RI+     +  ++ EE    V +
Sbjct: 307 GDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRL-EEHGKVVLV 365

Query: 256 LE 257
           LE
Sbjct: 366 LE 367



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 31/116 (26%), Positives = 56/116 (48%), Gaps = 6/116 (5%)

Query: 245 MYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQ 304
           ++EE L   ++    +  +R   A  L     + G  +  QG+ G  ++II +GS  V+ 
Sbjct: 236 IFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVT 295

Query: 305 RRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVAR-GPLKCVKLDRPRFERVL 359
                     V  L   D FG++AL+ + PRAAT++ R      +++D+  F R++
Sbjct: 296 HGKGL-----VTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRII 346


>gi|148727335 patatin-like phospholipase domain containing 7 isoform
           a [Homo sapiens]
          Length = 1342

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 66/274 (24%), Positives = 123/274 (44%), Gaps = 23/274 (8%)

Query: 87  PNPVVKGRRRRGAISAEVYT--EEDAASYVRKVIPKDYKTMAALAKAIEKNVL-FSHLDD 143
           P   V  + R+  + AE+ +   + + S+  + +    +   A+ +A +K++L    L+D
Sbjct: 435 PGSSVASKSRKSVMVAEIPSTVSQHSESHTDETLAS--RKSDAIFRAAKKDLLTLMKLED 492

Query: 144 NERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVY---VNNEWATSV---GEG 197
           +   D   A+  V   AG  V +QGD+  +   +  G   VY   + ++  T +     G
Sbjct: 493 SSLLDGRVALLHVP--AGTVVSRQGDQDASILFVVSGLLHVYQRKIGSQEDTCLFLTRPG 550

Query: 198 GSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKV-SIL 256
              G+LA++ G P   TVKA  +     I +  +  I+       RK     L    +++
Sbjct: 551 EMVGQLAVLTGEPLIFTVKANRDCSFLSISKAHFYEIM-------RKQPTVVLGVAHTVV 603

Query: 257 ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVG 316
           + +  + R  +  AL+ V+ E G+ I  QG+  D  +I+L G    + R+ + ++ +  G
Sbjct: 604 KRMSSFVR-QIDFALDWVEVEAGRAIYRQGDKSDCTYIMLSGRLRSVIRKDDGKKRL-AG 661

Query: 317 RLGPSDYFGEIALLMNRPRAATVVARGPLKCVKL 350
             G  D  G +  L ++ RA TV A    +  KL
Sbjct: 662 EYGRGDLVGVVETLTHQARATTVHAVRDSELAKL 695



 Score = 31.6 bits (70), Expect = 1.2
 Identities = 27/122 (22%), Positives = 50/122 (40%), Gaps = 1/122 (0%)

Query: 239 TLRKRKMYEEFLSKVSILESLDKWERLTVADA-LEPVQFEDGQKIVVQGEPGDEFFIILE 297
           TL  RK    F +    L +L K E  ++ D  +  +    G  +  QG+       ++ 
Sbjct: 467 TLASRKSDAIFRAAKKDLLTLMKLEDSSLLDGRVALLHVPAGTVVSRQGDQDASILFVVS 526

Query: 298 GSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFER 357
           G   V QR+  ++E   +    P +  G++A+L   P   TV A      + + +  F  
Sbjct: 527 GLLHVYQRKIGSQEDTCLFLTRPGEMVGQLAVLTGEPLIFTVKANRDCSFLSISKAHFYE 586

Query: 358 VL 359
           ++
Sbjct: 587 IM 588


>gi|148727290 patatin-like phospholipase domain containing 7 isoform
           b [Homo sapiens]
          Length = 1317

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 66/274 (24%), Positives = 123/274 (44%), Gaps = 23/274 (8%)

Query: 87  PNPVVKGRRRRGAISAEVYT--EEDAASYVRKVIPKDYKTMAALAKAIEKNVL-FSHLDD 143
           P   V  + R+  + AE+ +   + + S+  + +    +   A+ +A +K++L    L+D
Sbjct: 410 PGSSVASKSRKSVMVAEIPSTVSQHSESHTDETLAS--RKSDAIFRAAKKDLLTLMKLED 467

Query: 144 NERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVY---VNNEWATSV---GEG 197
           +   D   A+  V   AG  V +QGD+  +   +  G   VY   + ++  T +     G
Sbjct: 468 SSLLDGRVALLHVP--AGTVVSRQGDQDASILFVVSGLLHVYQRKIGSQEDTCLFLTRPG 525

Query: 198 GSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKV-SIL 256
              G+LA++ G P   TVKA  +     I +  +  I+       RK     L    +++
Sbjct: 526 EMVGQLAVLTGEPLIFTVKANRDCSFLSISKAHFYEIM-------RKQPTVVLGVAHTVV 578

Query: 257 ESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVG 316
           + +  + R  +  AL+ V+ E G+ I  QG+  D  +I+L G    + R+ + ++ +  G
Sbjct: 579 KRMSSFVR-QIDFALDWVEVEAGRAIYRQGDKSDCTYIMLSGRLRSVIRKDDGKKRL-AG 636

Query: 317 RLGPSDYFGEIALLMNRPRAATVVARGPLKCVKL 350
             G  D  G +  L ++ RA TV A    +  KL
Sbjct: 637 EYGRGDLVGVVETLTHQARATTVHAVRDSELAKL 670



 Score = 31.6 bits (70), Expect = 1.2
 Identities = 27/122 (22%), Positives = 50/122 (40%), Gaps = 1/122 (0%)

Query: 239 TLRKRKMYEEFLSKVSILESLDKWERLTVADA-LEPVQFEDGQKIVVQGEPGDEFFIILE 297
           TL  RK    F +    L +L K E  ++ D  +  +    G  +  QG+       ++ 
Sbjct: 442 TLASRKSDAIFRAAKKDLLTLMKLEDSSLLDGRVALLHVPAGTVVSRQGDQDASILFVVS 501

Query: 298 GSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFER 357
           G   V QR+  ++E   +    P +  G++A+L   P   TV A      + + +  F  
Sbjct: 502 GLLHVYQRKIGSQEDTCLFLTRPGEMVGQLAVLTGEPLIFTVKANRDCSFLSISKAHFYE 561

Query: 358 VL 359
           ++
Sbjct: 562 IM 563


>gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform
           b [Homo sapiens]
          Length = 867

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 40/143 (27%), Positives = 73/143 (51%), Gaps = 10/143 (6%)

Query: 139 SHLDDNERSDIFDAMFSVSFIAGETVI-QQGDEGDNFYVIDQGETDVYVNNEWAT-SVGE 196
           SHL    + ++   +   S   G TV+  QG+EG ++Y+I +G  +V +  +    ++ E
Sbjct: 214 SHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHE 273

Query: 197 GGSFGELALIYGTPRAAT-VKAKTNVKLWGIDRDSYRRILM---GSTLRKRKMYEEFLSK 252
           G  FG+LAL+   PRAA+ V  + N     +D++ + RIL     +T+R ++  ++ L  
Sbjct: 274 GDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVL-- 331

Query: 253 VSILESLDKWERLTVADALEPVQ 275
             +LE +    R +     +P Q
Sbjct: 332 --VLEKVPAGNRASNQGNSQPQQ 352



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 36/117 (30%), Positives = 57/117 (48%), Gaps = 8/117 (6%)

Query: 245 MYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVV-QGEPGDEFFIILEGSAAVL 303
           +YEE L  +  L  L    +  +A  L       G  ++  QGE G  ++IIL+GS  V+
Sbjct: 203 IYEELLH-IKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVV 261

Query: 304 QRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVAR-GPLKCVKLDRPRFERVL 359
                      V  L   D FG++AL+ + PRAA++V R      +++D+  F R+L
Sbjct: 262 IYGKG-----VVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRIL 313


>gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform
           a [Homo sapiens]
          Length = 1011

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 40/143 (27%), Positives = 73/143 (51%), Gaps = 10/143 (6%)

Query: 139 SHLDDNERSDIFDAMFSVSFIAGETVI-QQGDEGDNFYVIDQGETDVYVNNEWAT-SVGE 196
           SHL    + ++   +   S   G TV+  QG+EG ++Y+I +G  +V +  +    ++ E
Sbjct: 358 SHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHE 417

Query: 197 GGSFGELALIYGTPRAAT-VKAKTNVKLWGIDRDSYRRILM---GSTLRKRKMYEEFLSK 252
           G  FG+LAL+   PRAA+ V  + N     +D++ + RIL     +T+R ++  ++ L  
Sbjct: 418 GDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVL-- 475

Query: 253 VSILESLDKWERLTVADALEPVQ 275
             +LE +    R +     +P Q
Sbjct: 476 --VLEKVPAGNRASNQGNSQPQQ 496



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 25/81 (30%), Positives = 45/81 (55%), Gaps = 2/81 (2%)

Query: 277 EDGQKIVVQGEPGDEFFIILEGSAAV-LQRRSENEEFVEVGRLGPSDYFGEIALLMNRPR 335
           E G  +  QG+ G  ++ +L GS  V +   S +++ V +  LG    FGE ++L N PR
Sbjct: 65  EKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPR 123

Query: 336 AATVVARGPLKCVKLDRPRFE 356
            AT+V R   + +++++  F+
Sbjct: 124 HATIVTRESSELLRIEQKDFK 144



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 24/81 (29%), Positives = 45/81 (55%), Gaps = 8/81 (9%)

Query: 161 GETVIQQGDEGDNFYVIDQGETDVYVNNEWA-------TSVGEGGSFGELALIYGTPRAA 213
           G T+ +QGD G N+Y +  G  DV V+   +        ++G G +FGE +++  TPR A
Sbjct: 67  GITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPRHA 125

Query: 214 TVKAKTNVKLWGIDRDSYRRI 234
           T+  + + +L  I++  ++ +
Sbjct: 126 TIVTRESSELLRIEQKDFKAL 146



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 36/117 (30%), Positives = 57/117 (48%), Gaps = 8/117 (6%)

Query: 245 MYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVV-QGEPGDEFFIILEGSAAVL 303
           +YEE L  +  L  L    +  +A  L       G  ++  QGE G  ++IIL+GS  V+
Sbjct: 347 IYEELLH-IKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVV 405

Query: 304 QRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVAR-GPLKCVKLDRPRFERVL 359
                      V  L   D FG++AL+ + PRAA++V R      +++D+  F R+L
Sbjct: 406 IYGKG-----VVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRIL 457


>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 4 [Homo sapiens]
          Length = 1203

 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 29/114 (25%), Positives = 53/114 (46%)

Query: 130 KAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNE 189
           K +    LF++ D N  + +   +    F  G+ +I++G  G   Y I  G   V     
Sbjct: 588 KLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGN 647

Query: 190 WATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKR 243
             T + +G  FGE+ L+    R A+V+A T  +L+ +  D++  +L    + +R
Sbjct: 648 KETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRR 701



 Score = 36.6 bits (83), Expect = 0.039
 Identities = 25/84 (29%), Positives = 37/84 (44%), Gaps = 6/84 (7%)

Query: 276 FEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPR 335
           F+ G  I+ +G  G + + I  G  +VL + ++        +L    YFGEI LL    R
Sbjct: 616 FQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKET------KLADGSYFGEICLLTRGRR 669

Query: 336 AATVVARGPLKCVKLDRPRFERVL 359
            A+V A    +   L    F  VL
Sbjct: 670 TASVRADTYCRLYSLSVDNFNEVL 693


>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 2 [Homo sapiens]
          Length = 889

 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 28/114 (24%), Positives = 52/114 (45%)

Query: 130 KAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNE 189
           K +    LF++ D N  + +   +    F  G+ +I++G  G   Y I  G   V     
Sbjct: 537 KLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGN 596

Query: 190 WATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKR 243
               + +G  FGE+ L+    R A+V+A T  +L+ +  D++  +L    + +R
Sbjct: 597 KEMKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRR 650



 Score = 36.6 bits (83), Expect = 0.039
 Identities = 27/84 (32%), Positives = 38/84 (45%), Gaps = 6/84 (7%)

Query: 276 FEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPR 335
           F+ G  I+ +G  G + + I  G  +VL +   N+E     +L    YFGEI LL    R
Sbjct: 565 FQPGDYIIREGTIGKKMYFIQHGVVSVLTKG--NKEM----KLSDGSYFGEICLLTRGRR 618

Query: 336 AATVVARGPLKCVKLDRPRFERVL 359
            A+V A    +   L    F  VL
Sbjct: 619 TASVRADTYCRLYSLSVDNFNEVL 642


>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 3 [Homo sapiens]
          Length = 774

 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 28/107 (26%), Positives = 50/107 (46%)

Query: 137 LFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGE 196
           LF+H D +  + +   +    F  G+ V+++G  G   Y I  G   V       T + +
Sbjct: 428 LFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTD 487

Query: 197 GGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKR 243
           G  FGE+ L+    R A+V+A T  +L+ +  D +  +L    + +R
Sbjct: 488 GSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRR 534



 Score = 37.7 bits (86), Expect = 0.017
 Identities = 27/84 (32%), Positives = 37/84 (44%), Gaps = 6/84 (7%)

Query: 276 FEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPR 335
           F+ G  +V +G  G + + I  G  +VL R + +       RL    YFGEI LL    R
Sbjct: 449 FQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDT------RLTDGSYFGEICLLTRGRR 502

Query: 336 AATVVARGPLKCVKLDRPRFERVL 359
            A+V A    +   L    F  VL
Sbjct: 503 TASVRADTYCRLYSLSVDHFNAVL 526


>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 1 [Homo sapiens]
          Length = 890

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 28/114 (24%), Positives = 53/114 (46%)

Query: 130 KAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNE 189
           K +    LF++ D N  + +   +    F  G+ +I++G  G   Y I  G   V   + 
Sbjct: 468 KLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSS 527

Query: 190 WATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKR 243
               + +G  FGE+ L+    R A+V+A T  +L+ +  D++  +L    + +R
Sbjct: 528 KEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRR 581



 Score = 37.7 bits (86), Expect = 0.017
 Identities = 25/84 (29%), Positives = 37/84 (44%), Gaps = 6/84 (7%)

Query: 276 FEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPR 335
           F+ G  I+ +G  G + + I  G A V+ + S+  +  +        YFGEI LL    R
Sbjct: 496 FQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTD------GSYFGEICLLTKGRR 549

Query: 336 AATVVARGPLKCVKLDRPRFERVL 359
            A+V A    +   L    F  VL
Sbjct: 550 TASVRADTYCRLYSLSVDNFNEVL 573


>gi|116256487 patatin-like phospholipase domain containing 6 [Homo
           sapiens]
          Length = 1327

 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 49/199 (24%), Positives = 85/199 (42%), Gaps = 18/199 (9%)

Query: 160 AGETVIQQGDEGDNFYVIDQGETDVYVN-----NEWATSVGEGGSF-GELALIYGTPRAA 213
           AG  + +QGD+  + + +  G   VY        +    V + G   G+LA++ G P   
Sbjct: 487 AGTIIARQGDQDVSLHFVLWGCLHVYQRMIDKAEDVCLFVAQPGELVGQLAVLTGEPLIF 546

Query: 214 TVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVS-ILESLDKWERLTVADALE 272
           T++A+ +     I +  +  I+               +++S  +  +D         A++
Sbjct: 547 TLRAQRDCTFLRISKSDFYEIMRAQPSVVLSAAHTVAARMSPFVRQMD--------FAID 598

Query: 273 PVQFEDGQKIVVQGEPGDEFFIILEGS-AAVLQRRSENEEFVEVGRLGPSDYFGEIALLM 331
               E G+ +  QG+  D  +I+L G   +V+QR S  +E   VG  G  D  G +  L 
Sbjct: 599 WTAVEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKEL--VGEYGRGDLIGVVEALT 656

Query: 332 NRPRAATVVARGPLKCVKL 350
            +PRA TV A    +  KL
Sbjct: 657 RQPRATTVHAVRDTELAKL 675


>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
          Length = 809

 Score = 41.6 bits (96), Expect = 0.001
 Identities = 36/130 (27%), Positives = 57/130 (43%), Gaps = 13/130 (10%)

Query: 120 KDYKTMAALAKAIEKNV-------LFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGD 172
           K   T   LA AI+ N        LF   D     D+   + SV ++ G+ V ++G+ G 
Sbjct: 500 KTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGK 559

Query: 173 NFYVIDQGETDVYVNNEWA---TSVGEGGSFGELALIY---GTPRAATVKAKTNVKLWGI 226
             Y+I  GE  V    +      ++  G  FGE++L+    G  R A V A     L  +
Sbjct: 560 EMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTL 619

Query: 227 DRDSYRRILM 236
           D+ + + IL+
Sbjct: 620 DKKTLQEILV 629



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 33/113 (29%), Positives = 48/113 (42%), Gaps = 6/113 (5%)

Query: 250 LSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSEN 309
           +SKV + +  D      +   L+ V +  G  +  +GE G E +II  G   VL      
Sbjct: 519 ISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGT 578

Query: 310 EEFVEVGRLGPSDYFGEIALLM---NRPRAATVVARGPLKCVKLDRPRFERVL 359
           +  V    L     FGEI+LL       R A VVA G    + LD+   + +L
Sbjct: 579 KVLV---TLKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEIL 628


>gi|18201890 hypothetical protein LOC140894 [Homo sapiens]
          Length = 572

 Score = 39.7 bits (91), Expect = 0.005
 Identities = 33/151 (21%), Positives = 69/151 (45%), Gaps = 11/151 (7%)

Query: 164 VIQQGDEGDNFYVIDQGETDVYVNNEWATS--------VGEGGSFGELALIYGTPRAATV 215
           +I++G +G++FY I  G   +  + + +++        + +G  FGE+ +++ + R +T+
Sbjct: 143 IIKKGQKGNSFYFIYLGTVAITKDEDGSSAFLDPHPKLLHKGSCFGEMDVLHASVRRSTI 202

Query: 216 KAKTNVKLWGIDRDSYRRILMGSTLRKRKMYE-EFLSKVSILESLDKWERLTVADALEPV 274
                 +   +DR+ +    +   ++K   Y  EF  K+ +  S    E+L    A+  +
Sbjct: 203 VCMEETEFLVVDREDFFANKLDQEVQKDAQYRFEFFRKMELFASWSD-EKLWQLVAMAKI 261

Query: 275 Q-FEDGQKIVVQGEPGDEFFIILEGSAAVLQ 304
           + F  GQ I            I +GS  VL+
Sbjct: 262 ERFSYGQLISKDFGESPFIMFISKGSCEVLR 292


>gi|123173766 tubulin polyglutamylase complex subunit 1 [Homo
          sapiens]
          Length = 290

 Score = 38.9 bits (89), Expect = 0.008
 Identities = 17/56 (30%), Positives = 34/56 (60%)

Query: 2  ESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERL 57
          +SG  + S  A +    E ++++  +  +L+ +++++  ARPE P+AFL  YFE +
Sbjct: 19 DSGRQSVSRAAGAAESEEDFLRQVGVTEMLRAALLKVLEARPEEPIAFLAHYFENM 74


>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
          Length = 575

 Score = 38.5 bits (88), Expect = 0.010
 Identities = 23/81 (28%), Positives = 42/81 (51%), Gaps = 4/81 (4%)

Query: 250 LSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSEN 309
           LS+V I ++ +      +   L+P  +  G+ +  +G+ G E +II EG  AV+     +
Sbjct: 343 LSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVV----AD 398

Query: 310 EEFVEVGRLGPSDYFGEIALL 330
           +   +   LG   YFGEI+++
Sbjct: 399 DGITQYAVLGAGLYFGEISII 419



 Score = 36.2 bits (82), Expect = 0.050
 Identities = 32/129 (24%), Positives = 63/129 (48%), Gaps = 15/129 (11%)

Query: 157 SFIAGETVIQQGDEGDNFYVIDQGETDVYVNN---EWATSVGEGGSFGELALI------Y 207
           ++  GE V ++GD G   Y+I +G+  V  ++   ++A  +G G  FGE+++I       
Sbjct: 368 TYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAV-LGAGLYFGEISIINIKGNMS 426

Query: 208 GTPRAATVKAKTNVKLWGIDRDSYRRIL----MGSTLRKRKMYEEFLSKVSILESLDKWE 263
           G  R A +K+     L+ + ++  R +L       T+ + K   E L K++ L+   +  
Sbjct: 427 GNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQTIMEEK-GREILLKMNKLDVNAEAA 485

Query: 264 RLTVADALE 272
            + + +A E
Sbjct: 486 EIALQEATE 494


>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
           [Homo sapiens]
          Length = 676

 Score = 38.1 bits (87), Expect = 0.013
 Identities = 26/81 (32%), Positives = 37/81 (45%), Gaps = 4/81 (4%)

Query: 250 LSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSEN 309
           L KV I +  +    + +   L P  F  G  I  +G+ G E +II EG  AV+      
Sbjct: 459 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVT 518

Query: 310 EEFVEVGRLGPSDYFGEIALL 330
           +  V    L    YFGEI++L
Sbjct: 519 QFVV----LSDGSYFGEISIL 535



 Score = 32.0 bits (71), Expect = 0.95
 Identities = 22/99 (22%), Positives = 46/99 (46%), Gaps = 8/99 (8%)

Query: 158 FIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSV--GEGGSFGELALI------YGT 209
           F  G+ + ++GD G   Y+I++G+  V  ++     V   +G  FGE++++       G 
Sbjct: 485 FSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGN 544

Query: 210 PRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEE 248
            R A +++     L+ + +D     L      K+ + E+
Sbjct: 545 RRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEK 583


>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
           sapiens]
          Length = 694

 Score = 38.1 bits (87), Expect = 0.013
 Identities = 26/81 (32%), Positives = 37/81 (45%), Gaps = 4/81 (4%)

Query: 250 LSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSEN 309
           L KV I +  +    + +   L P  F  G  I  +G+ G E +II EG  AV+      
Sbjct: 477 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVT 536

Query: 310 EEFVEVGRLGPSDYFGEIALL 330
           +  V    L    YFGEI++L
Sbjct: 537 QFVV----LSDGSYFGEISIL 553



 Score = 32.0 bits (71), Expect = 0.95
 Identities = 22/99 (22%), Positives = 46/99 (46%), Gaps = 8/99 (8%)

Query: 158 FIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSV--GEGGSFGELALI------YGT 209
           F  G+ + ++GD G   Y+I++G+  V  ++     V   +G  FGE++++       G 
Sbjct: 503 FSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGN 562

Query: 210 PRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEE 248
            R A +++     L+ + +D     L      K+ + E+
Sbjct: 563 RRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEK 601


>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
            sapiens]
          Length = 1251

 Score = 36.2 bits (82), Expect = 0.050
 Identities = 32/113 (28%), Positives = 45/113 (39%), Gaps = 6/113 (5%)

Query: 250  LSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSEN 309
            +SKV++ +  D+     +   L  V +     +  +GE G E +II  G   VL      
Sbjct: 957  VSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGK 1016

Query: 310  EEFVEVGRLGPSDYFGEIALLM---NRPRAATVVARGPLKCVKLDRPRFERVL 359
               V    L     FGEI+LL       R A VVA G      LD+     +L
Sbjct: 1017 SVLV---TLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEIL 1066


>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
           [Homo sapiens]
          Length = 759

 Score = 35.8 bits (81), Expect = 0.066
 Identities = 25/81 (30%), Positives = 37/81 (45%), Gaps = 4/81 (4%)

Query: 250 LSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSEN 309
           L KV I    +    + +   L+P  +  G  I  +G+ G E +II EG  AV+      
Sbjct: 543 LKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVT 602

Query: 310 EEFVEVGRLGPSDYFGEIALL 330
           +  V    L    YFGEI++L
Sbjct: 603 QFVV----LSDGSYFGEISIL 619



 Score = 30.0 bits (66), Expect = 3.6
 Identities = 20/83 (24%), Positives = 39/83 (46%), Gaps = 8/83 (9%)

Query: 161 GETVIQQGDEGDNFYVIDQGETDVYVNNEWATSV--GEGGSFGELALI------YGTPRA 212
           G+ + ++GD G   Y+I +G+  V  ++     V   +G  FGE++++       G  R 
Sbjct: 572 GDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRT 631

Query: 213 ATVKAKTNVKLWGIDRDSYRRIL 235
           A +K+     L+ + +D     L
Sbjct: 632 ANIKSIGYSDLFCLSKDDLMEAL 654


>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
           sapiens]
          Length = 690

 Score = 35.8 bits (81), Expect = 0.066
 Identities = 25/81 (30%), Positives = 37/81 (45%), Gaps = 4/81 (4%)

Query: 250 LSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSEN 309
           L KV I    +    + +   L+P  +  G  I  +G+ G E +II EG  AV+      
Sbjct: 474 LKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVT 533

Query: 310 EEFVEVGRLGPSDYFGEIALL 330
           +  V    L    YFGEI++L
Sbjct: 534 QFVV----LSDGSYFGEISIL 550



 Score = 30.0 bits (66), Expect = 3.6
 Identities = 20/83 (24%), Positives = 39/83 (46%), Gaps = 8/83 (9%)

Query: 161 GETVIQQGDEGDNFYVIDQGETDVYVNNEWATSV--GEGGSFGELALI------YGTPRA 212
           G+ + ++GD G   Y+I +G+  V  ++     V   +G  FGE++++       G  R 
Sbjct: 503 GDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRT 562

Query: 213 ATVKAKTNVKLWGIDRDSYRRIL 235
           A +K+     L+ + +D     L
Sbjct: 563 ANIKSIGYSDLFCLSKDDLMEAL 585


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,121,945
Number of Sequences: 37866
Number of extensions: 621265
Number of successful extensions: 2295
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 2186
Number of HSP's gapped (non-prelim): 84
length of query: 381
length of database: 18,247,518
effective HSP length: 104
effective length of query: 277
effective length of database: 14,309,454
effective search space: 3963718758
effective search space used: 3963718758
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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