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Search of human proteins with 46409657
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|46409657 WD repeat domain 56 [Homo sapiens]
(777 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|46409657 WD repeat domain 56 [Homo sapiens] 1573 0.0
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 74 4e-13
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 68 4e-11
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 68 4e-11
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 68 4e-11
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 68 4e-11
gi|19913367 transducin beta-like 1Y [Homo sapiens] 64 7e-10
gi|19913365 transducin beta-like 1Y [Homo sapiens] 64 7e-10
gi|15150805 transducin beta-like 1Y [Homo sapiens] 64 7e-10
gi|46358428 selective LIM binding factor homolog [Homo sapiens] 62 2e-09
gi|148727341 serine/threonine kinase receptor associated protein... 56 1e-07
gi|21536371 telomerase-associated protein 1 [Homo sapiens] 54 7e-07
gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens] 53 9e-07
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 52 2e-06
gi|26665869 WD repeat domain 51B [Homo sapiens] 52 3e-06
gi|153791298 mitogen-activated protein kinase organizer 1 [Homo ... 51 4e-06
gi|14150114 mitogen-activated protein kinase organizer 1 [Homo s... 51 4e-06
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 50 6e-06
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 50 6e-06
gi|4757988 WD repeat domain 39 [Homo sapiens] 50 8e-06
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 50 1e-05
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 49 1e-05
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 49 2e-05
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 49 2e-05
gi|16554629 WD repeat domain 5 [Homo sapiens] 48 3e-05
gi|16554627 WD repeat domain 5 [Homo sapiens] 48 3e-05
gi|217330644 WD repeat domain 12 protein [Homo sapiens] 47 5e-05
gi|23199987 WD repeat domain 5B [Homo sapiens] 47 5e-05
gi|169403944 WD repeat domain 26 isoform b [Homo sapiens] 47 9e-05
gi|55743153 WD repeat domain 26 isoform a [Homo sapiens] 47 9e-05
>gi|46409657 WD repeat domain 56 [Homo sapiens]
Length = 777
Score = 1573 bits (4073), Expect = 0.0
Identities = 777/777 (100%), Positives = 777/777 (100%)
Query: 1 MRLKISLLKEPKHQELVSCVGWTTAEELYSCSDDHQIVKWNLLTSETTQIVKLPDDIYPI 60
MRLKISLLKEPKHQELVSCVGWTTAEELYSCSDDHQIVKWNLLTSETTQIVKLPDDIYPI
Sbjct: 1 MRLKISLLKEPKHQELVSCVGWTTAEELYSCSDDHQIVKWNLLTSETTQIVKLPDDIYPI 60
Query: 61 DFHWFPKSLGVKKQTQAESFVLTSSDGKFHLISKLGRVEKSVEAHCGAVLAGRWNYEGTA 120
DFHWFPKSLGVKKQTQAESFVLTSSDGKFHLISKLGRVEKSVEAHCGAVLAGRWNYEGTA
Sbjct: 61 DFHWFPKSLGVKKQTQAESFVLTSSDGKFHLISKLGRVEKSVEAHCGAVLAGRWNYEGTA 120
Query: 121 LVTVGEDGQIKIWSKTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAGKQLIIKPLQPNAK 180
LVTVGEDGQIKIWSKTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAGKQLIIKPLQPNAK
Sbjct: 121 LVTVGEDGQIKIWSKTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAGKQLIIKPLQPNAK 180
Query: 181 VLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGRPLYNSQPHEHPITSVAWAPD 240
VLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGRPLYNSQPHEHPITSVAWAPD
Sbjct: 181 VLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGRPLYNSQPHEHPITSVAWAPD 240
Query: 241 GELFAVGSFHTLRLCDKTGWSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHVVFAHVVE 300
GELFAVGSFHTLRLCDKTGWSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHVVFAHVVE
Sbjct: 241 GELFAVGSFHTLRLCDKTGWSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHVVFAHVVE 300
Query: 301 QHWEWKNFQVTLTKRRAMQVRNVLNDAVDLLEFRDRVIKASLNYAHLVVSTSLQCYVFST 360
QHWEWKNFQVTLTKRRAMQVRNVLNDAVDLLEFRDRVIKASLNYAHLVVSTSLQCYVFST
Sbjct: 301 QHWEWKNFQVTLTKRRAMQVRNVLNDAVDLLEFRDRVIKASLNYAHLVVSTSLQCYVFST 360
Query: 361 KNWNTPIIFDLKEGTVSLILQAERHFLLVDGSSIYLYSYEGRFISSPKFPGMRTDILNAQ 420
KNWNTPIIFDLKEGTVSLILQAERHFLLVDGSSIYLYSYEGRFISSPKFPGMRTDILNAQ
Sbjct: 361 KNWNTPIIFDLKEGTVSLILQAERHFLLVDGSSIYLYSYEGRFISSPKFPGMRTDILNAQ 420
Query: 421 TVSLSNDTIAIRDKADEKIIFLFEASTGKPLGDGKFLSHKNEILEIALDQKGLTNDRKIA 480
TVSLSNDTIAIRDKADEKIIFLFEASTGKPLGDGKFLSHKNEILEIALDQKGLTNDRKIA
Sbjct: 421 TVSLSNDTIAIRDKADEKIIFLFEASTGKPLGDGKFLSHKNEILEIALDQKGLTNDRKIA 480
Query: 481 FIDKNRDLCITSVKRFGKEEQIIKLGTMVHTLAWNDTCNILCGLQDTRFIVWYYPNTVYV 540
FIDKNRDLCITSVKRFGKEEQIIKLGTMVHTLAWNDTCNILCGLQDTRFIVWYYPNTVYV
Sbjct: 481 FIDKNRDLCITSVKRFGKEEQIIKLGTMVHTLAWNDTCNILCGLQDTRFIVWYYPNTVYV 540
Query: 541 DRDILPKTLYERDASEFSKNPHIVSFVGNQVTIRRADGSLVHISITPYPAILHEYVSSSK 600
DRDILPKTLYERDASEFSKNPHIVSFVGNQVTIRRADGSLVHISITPYPAILHEYVSSSK
Sbjct: 541 DRDILPKTLYERDASEFSKNPHIVSFVGNQVTIRRADGSLVHISITPYPAILHEYVSSSK 600
Query: 601 WEDAVRLCRFVKEQTMWACLAAMAVANRDMTTAEIAYAAIGEIDKVQYINSIKNLPSKES 660
WEDAVRLCRFVKEQTMWACLAAMAVANRDMTTAEIAYAAIGEIDKVQYINSIKNLPSKES
Sbjct: 601 WEDAVRLCRFVKEQTMWACLAAMAVANRDMTTAEIAYAAIGEIDKVQYINSIKNLPSKES 660
Query: 661 KMAHILLFSGNIQEAEIVLLQAGLVYQAIQININLYNWERALELAVKYKTHVDTVLAYRQ 720
KMAHILLFSGNIQEAEIVLLQAGLVYQAIQININLYNWERALELAVKYKTHVDTVLAYRQ
Sbjct: 661 KMAHILLFSGNIQEAEIVLLQAGLVYQAIQININLYNWERALELAVKYKTHVDTVLAYRQ 720
Query: 721 KFLETFGKQETNKRYLHYAEGLQIDWEKIKAKIEMEITKEREQSSSSQSSKSIGLKP 777
KFLETFGKQETNKRYLHYAEGLQIDWEKIKAKIEMEITKEREQSSSSQSSKSIGLKP
Sbjct: 721 KFLETFGKQETNKRYLHYAEGLQIDWEKIKAKIEMEITKEREQSSSSQSSKSIGLKP 777
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 74.3 bits (181), Expect = 4e-13
Identities = 54/177 (30%), Positives = 77/177 (43%), Gaps = 15/177 (8%)
Query: 114 WNYEGTALVTVGEDGQIKIWSKTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAG--KQLI 171
WN EGT L T DG +IW+K G L STL Q P++++ W +L +AG K I
Sbjct: 233 WNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFIL-SAGVDKTTI 291
Query: 172 IKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGRPLYNSQPHEHP 231
I Q+ H L VDW S N + + C + RP+ Q H +
Sbjct: 292 IWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNE 351
Query: 232 ITSVAWAPDGELFAVGSFH-TLRLCDKTGWSYALE------KPNTGSIFNIAWSIDG 281
+ ++ W P G L A S TL++ WS + + + I+ I WS G
Sbjct: 352 VNAIKWDPTGNLLASCSDDMTLKI-----WSMKQDNCVHDLQAHNKEIYTIKWSPTG 403
Score = 65.9 bits (159), Expect = 1e-10
Identities = 66/349 (18%), Positives = 122/349 (34%), Gaps = 77/349 (22%)
Query: 13 HQELVSCVGWTTAEELY-SCSDDHQIVKWNLL---TSETTQIV----------KLPDDIY 58
H+ V W +L S S D WNL TS +TQ+V +P +
Sbjct: 168 HESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKD 227
Query: 59 PIDFHWFPKSLGVKKQTQAESFVLTSSDGKFHLISKLGRVEKSVEAHCGAVLAGRWNYEG 118
W ++ S DG + +K G + ++ H G + A +WN +G
Sbjct: 228 VTSLDW---------NSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKG 278
Query: 119 TALVTVGEDGQIKIW-SKTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAGKQLIIKPLQP 177
+++ G D IW + TG + P V W ++ + + + L
Sbjct: 279 NFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQ 338
Query: 178 NAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVW-----------DSYGRPLYNSQ 226
+ + ++ H + + W+ +L+ S +D K+W ++ + +Y +
Sbjct: 339 DRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIK 398
Query: 227 -----------------------------------------PHEHPITSVAWAPDGELFA 245
H+ P+ SVA++PDG A
Sbjct: 399 WSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLA 458
Query: 246 VGSF-HTLRLCDKTGWSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHV 293
GSF + + + + TG IF + W+ G ++ + +G V
Sbjct: 459 SGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSV 507
Score = 42.7 bits (99), Expect = 0.001
Identities = 31/127 (24%), Positives = 49/127 (38%), Gaps = 16/127 (12%)
Query: 177 PNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGRPLYNSQ---------- 226
P K + + H+ + WN V+DL+ S D ++W+ S
Sbjct: 158 PPNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIRE 217
Query: 227 -----PHEHPITSVAWAPDGELFAVGSFHTL-RLCDKTGWSYALEKPNTGSIFNIAWSID 280
P +TS+ W +G L A GS+ R+ K G + + G IF + W+
Sbjct: 218 GGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKK 277
Query: 281 GTQIAGA 287
G I A
Sbjct: 278 GNFILSA 284
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 67.8 bits (164), Expect = 4e-11
Identities = 66/288 (22%), Positives = 111/288 (38%), Gaps = 50/288 (17%)
Query: 12 KHQELVSCVGWTT-AEELYSCSDDHQIVKWNLLTSETTQIVKLPDDIYPIDFHWFPKSLG 70
+H+ + + W + S D + W+ T E Q FH P +L
Sbjct: 276 QHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQ---------QFPFHSAP-ALD 325
Query: 71 VKKQTQAESFVLTSSDGKFHLISKLG--RVEKSVEAHCGAVLAGRWNYEGTALVTVGEDG 128
V Q +F S+D H + +LG R K+ + H V A +W+ G L + +D
Sbjct: 326 VDWQNNT-TFASCSTDMCIH-VCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDM 383
Query: 129 QIKIWS-KTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAGKQLIIKPLQPNAKVLQWKAH 187
+KIWS K + L +Y++ W P PN+ ++
Sbjct: 384 TLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATS------------NPNSNIM----- 426
Query: 188 DGIILKVDWNSVNDLILSAGEDCKYKVWD-SYGRPLYNSQPHEHPITSVAWAPDGELFAV 246
+ SA D ++WD G + H+ P+ SVA++PDG+ A
Sbjct: 427 ---------------LASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLAS 471
Query: 247 GSF-HTLRLCDKTGWSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHV 293
GSF + + + + TG IF + W+ G ++ + +G V
Sbjct: 472 GSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSV 519
Score = 67.4 bits (163), Expect = 5e-11
Identities = 51/177 (28%), Positives = 75/177 (42%), Gaps = 15/177 (8%)
Query: 114 WNYEGTALVTVGEDGQIKIWSKTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAG--KQLI 171
WN GT L T DG +IW++ G L STL Q P++++ W +L +AG K I
Sbjct: 245 WNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYIL-SAGVDKTTI 303
Query: 172 IKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGRPLYNSQPHEHP 231
I Q+ H L VDW + + + C + RP+ Q H +
Sbjct: 304 IWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNE 363
Query: 232 ITSVAWAPDGELFAVGSFH-TLRLCDKTGWSYALE------KPNTGSIFNIAWSIDG 281
+ ++ W P G L A S TL++ WS E + + I+ I WS G
Sbjct: 364 VNAIKWDPSGMLLASCSDDMTLKI-----WSMKQEVCIHDLQAHNKEIYTIKWSPTG 415
Score = 43.1 bits (100), Expect = 0.001
Identities = 32/127 (25%), Positives = 53/127 (41%), Gaps = 16/127 (12%)
Query: 177 PNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVW----DSYG-----------RP 221
P++K + H+ + WN V+DL+ S D ++W +S G R
Sbjct: 170 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 229
Query: 222 LYNSQPHEHPITSVAWAPDGELFAVGSFHTL-RLCDKTGWSYALEKPNTGSIFNIAWSID 280
+ P +TS+ W +G L A GS+ R+ + G + + G IF + W+
Sbjct: 230 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRK 289
Query: 281 GTQIAGA 287
G I A
Sbjct: 290 GNYILSA 296
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 67.8 bits (164), Expect = 4e-11
Identities = 66/288 (22%), Positives = 111/288 (38%), Gaps = 50/288 (17%)
Query: 12 KHQELVSCVGWTT-AEELYSCSDDHQIVKWNLLTSETTQIVKLPDDIYPIDFHWFPKSLG 70
+H+ + + W + S D + W+ T E Q FH P +L
Sbjct: 276 QHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQ---------QFPFHSAP-ALD 325
Query: 71 VKKQTQAESFVLTSSDGKFHLISKLG--RVEKSVEAHCGAVLAGRWNYEGTALVTVGEDG 128
V Q +F S+D H + +LG R K+ + H V A +W+ G L + +D
Sbjct: 326 VDWQNNT-TFASCSTDMCIH-VCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDM 383
Query: 129 QIKIWS-KTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAGKQLIIKPLQPNAKVLQWKAH 187
+KIWS K + L +Y++ W P PN+ ++
Sbjct: 384 TLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATS------------NPNSNIM----- 426
Query: 188 DGIILKVDWNSVNDLILSAGEDCKYKVWD-SYGRPLYNSQPHEHPITSVAWAPDGELFAV 246
+ SA D ++WD G + H+ P+ SVA++PDG+ A
Sbjct: 427 ---------------LASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLAS 471
Query: 247 GSF-HTLRLCDKTGWSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHV 293
GSF + + + + TG IF + W+ G ++ + +G V
Sbjct: 472 GSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSV 519
Score = 67.4 bits (163), Expect = 5e-11
Identities = 51/177 (28%), Positives = 75/177 (42%), Gaps = 15/177 (8%)
Query: 114 WNYEGTALVTVGEDGQIKIWSKTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAG--KQLI 171
WN GT L T DG +IW++ G L STL Q P++++ W +L +AG K I
Sbjct: 245 WNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYIL-SAGVDKTTI 303
Query: 172 IKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGRPLYNSQPHEHP 231
I Q+ H L VDW + + + C + RP+ Q H +
Sbjct: 304 IWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNE 363
Query: 232 ITSVAWAPDGELFAVGSFH-TLRLCDKTGWSYALE------KPNTGSIFNIAWSIDG 281
+ ++ W P G L A S TL++ WS E + + I+ I WS G
Sbjct: 364 VNAIKWDPSGMLLASCSDDMTLKI-----WSMKQEVCIHDLQAHNKEIYTIKWSPTG 415
Score = 43.1 bits (100), Expect = 0.001
Identities = 32/127 (25%), Positives = 53/127 (41%), Gaps = 16/127 (12%)
Query: 177 PNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVW----DSYG-----------RP 221
P++K + H+ + WN V+DL+ S D ++W +S G R
Sbjct: 170 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 229
Query: 222 LYNSQPHEHPITSVAWAPDGELFAVGSFHTL-RLCDKTGWSYALEKPNTGSIFNIAWSID 280
+ P +TS+ W +G L A GS+ R+ + G + + G IF + W+
Sbjct: 230 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRK 289
Query: 281 GTQIAGA 287
G I A
Sbjct: 290 GNYILSA 296
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 67.8 bits (164), Expect = 4e-11
Identities = 66/288 (22%), Positives = 111/288 (38%), Gaps = 50/288 (17%)
Query: 12 KHQELVSCVGWTT-AEELYSCSDDHQIVKWNLLTSETTQIVKLPDDIYPIDFHWFPKSLG 70
+H+ + + W + S D + W+ T E Q FH P +L
Sbjct: 327 QHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQ---------QFPFHSAP-ALD 376
Query: 71 VKKQTQAESFVLTSSDGKFHLISKLG--RVEKSVEAHCGAVLAGRWNYEGTALVTVGEDG 128
V Q +F S+D H + +LG R K+ + H V A +W+ G L + +D
Sbjct: 377 VDWQNNT-TFASCSTDMCIH-VCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDM 434
Query: 129 QIKIWS-KTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAGKQLIIKPLQPNAKVLQWKAH 187
+KIWS K + L +Y++ W P PN+ ++
Sbjct: 435 TLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATS------------NPNSNIM----- 477
Query: 188 DGIILKVDWNSVNDLILSAGEDCKYKVWD-SYGRPLYNSQPHEHPITSVAWAPDGELFAV 246
+ SA D ++WD G + H+ P+ SVA++PDG+ A
Sbjct: 478 ---------------LASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLAS 522
Query: 247 GSF-HTLRLCDKTGWSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHV 293
GSF + + + + TG IF + W+ G ++ + +G V
Sbjct: 523 GSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSV 570
Score = 67.4 bits (163), Expect = 5e-11
Identities = 51/177 (28%), Positives = 75/177 (42%), Gaps = 15/177 (8%)
Query: 114 WNYEGTALVTVGEDGQIKIWSKTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAG--KQLI 171
WN GT L T DG +IW++ G L STL Q P++++ W +L +AG K I
Sbjct: 296 WNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYIL-SAGVDKTTI 354
Query: 172 IKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGRPLYNSQPHEHP 231
I Q+ H L VDW + + + C + RP+ Q H +
Sbjct: 355 IWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNE 414
Query: 232 ITSVAWAPDGELFAVGSFH-TLRLCDKTGWSYALE------KPNTGSIFNIAWSIDG 281
+ ++ W P G L A S TL++ WS E + + I+ I WS G
Sbjct: 415 VNAIKWDPSGMLLASCSDDMTLKI-----WSMKQEVCIHDLQAHNKEIYTIKWSPTG 466
Score = 43.1 bits (100), Expect = 0.001
Identities = 32/127 (25%), Positives = 53/127 (41%), Gaps = 16/127 (12%)
Query: 177 PNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVW----DSYG-----------RP 221
P++K + H+ + WN V+DL+ S D ++W +S G R
Sbjct: 221 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 280
Query: 222 LYNSQPHEHPITSVAWAPDGELFAVGSFHTL-RLCDKTGWSYALEKPNTGSIFNIAWSID 280
+ P +TS+ W +G L A GS+ R+ + G + + G IF + W+
Sbjct: 281 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRK 340
Query: 281 GTQIAGA 287
G I A
Sbjct: 341 GNYILSA 347
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 67.8 bits (164), Expect = 4e-11
Identities = 66/288 (22%), Positives = 111/288 (38%), Gaps = 50/288 (17%)
Query: 12 KHQELVSCVGWTT-AEELYSCSDDHQIVKWNLLTSETTQIVKLPDDIYPIDFHWFPKSLG 70
+H+ + + W + S D + W+ T E Q FH P +L
Sbjct: 327 QHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQ---------QFPFHSAP-ALD 376
Query: 71 VKKQTQAESFVLTSSDGKFHLISKLG--RVEKSVEAHCGAVLAGRWNYEGTALVTVGEDG 128
V Q +F S+D H + +LG R K+ + H V A +W+ G L + +D
Sbjct: 377 VDWQNNT-TFASCSTDMCIH-VCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDM 434
Query: 129 QIKIWS-KTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAGKQLIIKPLQPNAKVLQWKAH 187
+KIWS K + L +Y++ W P PN+ ++
Sbjct: 435 TLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATS------------NPNSNIM----- 477
Query: 188 DGIILKVDWNSVNDLILSAGEDCKYKVWD-SYGRPLYNSQPHEHPITSVAWAPDGELFAV 246
+ SA D ++WD G + H+ P+ SVA++PDG+ A
Sbjct: 478 ---------------LASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLAS 522
Query: 247 GSF-HTLRLCDKTGWSYALEKPNTGSIFNIAWSIDGTQIAGACGNGHV 293
GSF + + + + TG IF + W+ G ++ + +G V
Sbjct: 523 GSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSV 570
Score = 67.4 bits (163), Expect = 5e-11
Identities = 51/177 (28%), Positives = 75/177 (42%), Gaps = 15/177 (8%)
Query: 114 WNYEGTALVTVGEDGQIKIWSKTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAG--KQLI 171
WN GT L T DG +IW++ G L STL Q P++++ W +L +AG K I
Sbjct: 296 WNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYIL-SAGVDKTTI 354
Query: 172 IKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGRPLYNSQPHEHP 231
I Q+ H L VDW + + + C + RP+ Q H +
Sbjct: 355 IWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNE 414
Query: 232 ITSVAWAPDGELFAVGSFH-TLRLCDKTGWSYALE------KPNTGSIFNIAWSIDG 281
+ ++ W P G L A S TL++ WS E + + I+ I WS G
Sbjct: 415 VNAIKWDPSGMLLASCSDDMTLKI-----WSMKQEVCIHDLQAHNKEIYTIKWSPTG 466
Score = 43.1 bits (100), Expect = 0.001
Identities = 32/127 (25%), Positives = 53/127 (41%), Gaps = 16/127 (12%)
Query: 177 PNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVW----DSYG-----------RP 221
P++K + H+ + WN V+DL+ S D ++W +S G R
Sbjct: 221 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 280
Query: 222 LYNSQPHEHPITSVAWAPDGELFAVGSFHTL-RLCDKTGWSYALEKPNTGSIFNIAWSID 280
+ P +TS+ W +G L A GS+ R+ + G + + G IF + W+
Sbjct: 281 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRK 340
Query: 281 GTQIAGA 287
G I A
Sbjct: 341 GNYILSA 347
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 63.5 bits (153), Expect = 7e-10
Identities = 49/177 (27%), Positives = 75/177 (42%), Gaps = 15/177 (8%)
Query: 114 WNYEGTALVTVGEDGQIKIWSKTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAG--KQLI 171
WN +GT L DG +IW++ G L STL Q P++++ W VL +AG K I
Sbjct: 243 WNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVL-SAGVDKTTI 301
Query: 172 IKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGRPLYNSQPHEHP 231
I Q+ H L VDW + + + C + P+ Q H +
Sbjct: 302 IWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNE 361
Query: 232 ITSVAWAPDGELFAVGSFH-TLRLCDKTGWSYALE------KPNTGSIFNIAWSIDG 281
+ ++ W P G L A S TL++ WS + + ++ I+ I WS G
Sbjct: 362 VNAIKWDPSGMLLASCSDDMTLKI-----WSMKQDACVHDLQAHSKEIYTIKWSPTG 413
Score = 62.0 bits (149), Expect = 2e-09
Identities = 57/264 (21%), Positives = 100/264 (37%), Gaps = 54/264 (20%)
Query: 84 SSDGKFHLISKLGRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQIKIW-SKTGMLRST 142
S DG + ++ G + ++ H G + A +WN +G +++ G D IW + TG +
Sbjct: 254 SYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQ 313
Query: 143 LAQQGTPVYSVAW--------------------GPD--------------------SEKV 162
P V W G D S +
Sbjct: 314 FPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGML 373
Query: 163 LYTAGKQLIIK--PLQPNAKVLQWKAHDGIILKVDWNSVND---------LILSAGEDCK 211
L + + +K ++ +A V +AH I + W+ ++ SA D
Sbjct: 374 LASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDST 433
Query: 212 YKVWD-SYGRPLYNSQPHEHPITSVAWAPDGELFAVGSFHT-LRLCDKTGWSYALEKPNT 269
++WD G + H+ P+ SVA++PDG+ A GSF + + + S T
Sbjct: 434 VRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGT 493
Query: 270 GSIFNIAWSIDGTQIAGACGNGHV 293
G IF + W+ G ++ + +G V
Sbjct: 494 GGIFEVCWNARGDKVGASASDGSV 517
Score = 43.1 bits (100), Expect = 0.001
Identities = 32/127 (25%), Positives = 52/127 (40%), Gaps = 16/127 (12%)
Query: 177 PNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVW----DSYG-----------RP 221
P K + H+ + WN V+DL+ S D ++W +S G R
Sbjct: 168 PPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 227
Query: 222 LYNSQPHEHPITSVAWAPDGELFAVGSFHTL-RLCDKTGWSYALEKPNTGSIFNIAWSID 280
+ P +TS+ W DG L A+GS+ R+ + G + + G IF + W+
Sbjct: 228 GGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKK 287
Query: 281 GTQIAGA 287
G + A
Sbjct: 288 GNYVLSA 294
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 63.5 bits (153), Expect = 7e-10
Identities = 49/177 (27%), Positives = 75/177 (42%), Gaps = 15/177 (8%)
Query: 114 WNYEGTALVTVGEDGQIKIWSKTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAG--KQLI 171
WN +GT L DG +IW++ G L STL Q P++++ W VL +AG K I
Sbjct: 243 WNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVL-SAGVDKTTI 301
Query: 172 IKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGRPLYNSQPHEHP 231
I Q+ H L VDW + + + C + P+ Q H +
Sbjct: 302 IWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNE 361
Query: 232 ITSVAWAPDGELFAVGSFH-TLRLCDKTGWSYALE------KPNTGSIFNIAWSIDG 281
+ ++ W P G L A S TL++ WS + + ++ I+ I WS G
Sbjct: 362 VNAIKWDPSGMLLASCSDDMTLKI-----WSMKQDACVHDLQAHSKEIYTIKWSPTG 413
Score = 62.0 bits (149), Expect = 2e-09
Identities = 57/264 (21%), Positives = 100/264 (37%), Gaps = 54/264 (20%)
Query: 84 SSDGKFHLISKLGRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQIKIW-SKTGMLRST 142
S DG + ++ G + ++ H G + A +WN +G +++ G D IW + TG +
Sbjct: 254 SYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQ 313
Query: 143 LAQQGTPVYSVAW--------------------GPD--------------------SEKV 162
P V W G D S +
Sbjct: 314 FPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGML 373
Query: 163 LYTAGKQLIIK--PLQPNAKVLQWKAHDGIILKVDWNSVND---------LILSAGEDCK 211
L + + +K ++ +A V +AH I + W+ ++ SA D
Sbjct: 374 LASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDST 433
Query: 212 YKVWD-SYGRPLYNSQPHEHPITSVAWAPDGELFAVGSFHT-LRLCDKTGWSYALEKPNT 269
++WD G + H+ P+ SVA++PDG+ A GSF + + + S T
Sbjct: 434 VRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGT 493
Query: 270 GSIFNIAWSIDGTQIAGACGNGHV 293
G IF + W+ G ++ + +G V
Sbjct: 494 GGIFEVCWNARGDKVGASASDGSV 517
Score = 43.1 bits (100), Expect = 0.001
Identities = 32/127 (25%), Positives = 52/127 (40%), Gaps = 16/127 (12%)
Query: 177 PNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVW----DSYG-----------RP 221
P K + H+ + WN V+DL+ S D ++W +S G R
Sbjct: 168 PPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 227
Query: 222 LYNSQPHEHPITSVAWAPDGELFAVGSFHTL-RLCDKTGWSYALEKPNTGSIFNIAWSID 280
+ P +TS+ W DG L A+GS+ R+ + G + + G IF + W+
Sbjct: 228 GGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKK 287
Query: 281 GTQIAGA 287
G + A
Sbjct: 288 GNYVLSA 294
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 63.5 bits (153), Expect = 7e-10
Identities = 49/177 (27%), Positives = 75/177 (42%), Gaps = 15/177 (8%)
Query: 114 WNYEGTALVTVGEDGQIKIWSKTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAG--KQLI 171
WN +GT L DG +IW++ G L STL Q P++++ W VL +AG K I
Sbjct: 243 WNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVL-SAGVDKTTI 301
Query: 172 IKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGRPLYNSQPHEHP 231
I Q+ H L VDW + + + C + P+ Q H +
Sbjct: 302 IWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNE 361
Query: 232 ITSVAWAPDGELFAVGSFH-TLRLCDKTGWSYALE------KPNTGSIFNIAWSIDG 281
+ ++ W P G L A S TL++ WS + + ++ I+ I WS G
Sbjct: 362 VNAIKWDPSGMLLASCSDDMTLKI-----WSMKQDACVHDLQAHSKEIYTIKWSPTG 413
Score = 62.0 bits (149), Expect = 2e-09
Identities = 57/264 (21%), Positives = 100/264 (37%), Gaps = 54/264 (20%)
Query: 84 SSDGKFHLISKLGRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQIKIW-SKTGMLRST 142
S DG + ++ G + ++ H G + A +WN +G +++ G D IW + TG +
Sbjct: 254 SYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQ 313
Query: 143 LAQQGTPVYSVAW--------------------GPD--------------------SEKV 162
P V W G D S +
Sbjct: 314 FPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGML 373
Query: 163 LYTAGKQLIIK--PLQPNAKVLQWKAHDGIILKVDWNSVND---------LILSAGEDCK 211
L + + +K ++ +A V +AH I + W+ ++ SA D
Sbjct: 374 LASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDST 433
Query: 212 YKVWD-SYGRPLYNSQPHEHPITSVAWAPDGELFAVGSFHT-LRLCDKTGWSYALEKPNT 269
++WD G + H+ P+ SVA++PDG+ A GSF + + + S T
Sbjct: 434 VRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGT 493
Query: 270 GSIFNIAWSIDGTQIAGACGNGHV 293
G IF + W+ G ++ + +G V
Sbjct: 494 GGIFEVCWNARGDKVGASASDGSV 517
Score = 43.1 bits (100), Expect = 0.001
Identities = 32/127 (25%), Positives = 52/127 (40%), Gaps = 16/127 (12%)
Query: 177 PNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVW----DSYG-----------RP 221
P K + H+ + WN V+DL+ S D ++W +S G R
Sbjct: 168 PPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 227
Query: 222 LYNSQPHEHPITSVAWAPDGELFAVGSFHTL-RLCDKTGWSYALEKPNTGSIFNIAWSID 280
+ P +TS+ W DG L A+GS+ R+ + G + + G IF + W+
Sbjct: 228 GGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKK 287
Query: 281 GTQIAGA 287
G + A
Sbjct: 288 GNYVLSA 294
>gi|46358428 selective LIM binding factor homolog [Homo sapiens]
Length = 1749
Score = 62.0 bits (149), Expect = 2e-09
Identities = 100/557 (17%), Positives = 217/557 (38%), Gaps = 92/557 (16%)
Query: 203 ILSAGEDCKYKVWDSYGRPL----YNSQPHEHPITSVAWAPDGELFAVGSFHTLRLCD-- 256
I++AG D K + G L Y+ P E T+ +P G+ +GS+ LR+ +
Sbjct: 210 IVAAGCDRKIVAYGKEGHMLQTFDYSRDPQEREFTTAVSSPGGQSVVLGSYDRLRVFNWI 269
Query: 257 --KTGWSYALEK--PNTGSIFNIAWSIDGTQI-AGACGNGHVVFAHVVEQHWEWKNFQVT 311
++ W A K N +I +AW DG+++ G G F + + F++T
Sbjct: 270 PRRSIWEEAKPKEITNLYTITALAWKRDGSRLCVGTLCGGVEQFDCCLRRSIYKNKFELT 329
Query: 312 LTKRRAMQVRNVLNDAVDLLE----FRDRVIKASLNYAHLVVSTSLQCYVFSTKNWN--T 365
+ V+N+ + +L+ + +K +LV TS + + N N +
Sbjct: 330 YVGPSQVIVKNLSSGTRVVLKSHYGYEVEEVKILGKERYLVAHTS-ETLLLGDLNTNRLS 388
Query: 366 PIIFDLKEGTVSLILQAERHFLLVDGSSIYLYSYEGRFISSPKFPGMRTDILNAQTVSLS 425
I + G + E ++ + + L Y ++ +RT+ +N +S+
Sbjct: 389 EIAWQGSGGNEKYFFENENVCMIFNAGELTLVEYG----NNDTLGSVRTEFMNPHLISVR 444
Query: 426 -NDTIAIRDKADEKIIFLFEAST--------GKPLGDGKFLSHKNEILEIALDQKGLTND 476
N+ + ++K+ +L + T G +G +SH++ + + L++ G
Sbjct: 445 INERCQRGTEDNKKLAYLIDIKTIAIVDLIGGYNIGT---VSHESRVDWLELNETG---- 497
Query: 477 RKIAFIDKNRDLCITSVKRFGKEEQIIKLGTMVHTLAWNDTCNILCGLQDTRFIVWYYPN 536
K+ F D+ L + ++ K + + W ++L VWY
Sbjct: 498 HKLLFRDRKLRLHLYDIESCSK----TMILNFCSYMQWVPGSDVLVAQNRNSLCVWY--- 550
Query: 537 TVYVDRDILPKTLYERDASEFSKNPHIVSFVGNQVTIRRADGS---LVHISITPYPAILH 593
E + + + G+ + + R G +V +T L
Sbjct: 551 -----------------NIEAPERVTMFTIRGDVIGLERGGGKTEVMVMEGVTTVAYTLD 593
Query: 594 E-------------YVSSSKWEDAVRLCRFVKEQTMWACLAAMAVANRDMTTAEIAYAAI 640
E Y+ ++ + + + + + + MW L+ +A+ R + AE ++A+
Sbjct: 594 EGLIEFGTAIDDGNYIRATAFLETLEMT--PETEAMWKTLSKLALEARQLHIAERCFSAL 651
Query: 641 GEIDKVQYINSIKNLPSKESK------------MAHILLFSGNIQEAEIVLLQAGLVYQA 688
G++ K ++++ + + S+ A + + N + AE++ L+ V +A
Sbjct: 652 GQVAKARFLHETNEIADQVSREYGGEGTDFYQVRARLAMLEKNYKLAEMIFLEQNAVEEA 711
Query: 689 IQININLYNWERALELA 705
+ + L+ W+ + +A
Sbjct: 712 MGMYQELHRWDECIAVA 728
>gi|148727341 serine/threonine kinase receptor associated protein
[Homo sapiens]
Length = 350
Score = 56.2 bits (134), Expect = 1e-07
Identities = 51/198 (25%), Positives = 86/198 (43%), Gaps = 8/198 (4%)
Query: 75 TQAESFVLTSSDGKFHLISKLGRVE---KSVEAHCGAVLAGRWNYEGTALVTVGEDGQIK 131
TQ +++LT K I L + E K + H + W E +++ +D ++
Sbjct: 109 TQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSA-DDKTVR 167
Query: 132 IWSKTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAGKQLIIKPLQPNAKVLQWKAHDGII 191
+W M V S+ + P+ E ++ T G+ + + ++A I
Sbjct: 168 LWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEA-PATI 226
Query: 192 LKVDWNSVNDLILSAGEDCK-YKVWDSYGRPLYNSQPHEHPITSVAWAPDGELFAVGSFH 250
+ + +++ GED K YK + G L + + H PI V ++PDGEL+A GS
Sbjct: 227 NSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSED 286
Query: 251 -TLRLCDK-TGWSYALEK 266
TLRL G +Y L K
Sbjct: 287 GTLRLWQTVVGKTYGLWK 304
Score = 43.5 bits (101), Expect = 7e-04
Identities = 40/146 (27%), Positives = 66/146 (45%), Gaps = 7/146 (4%)
Query: 105 HCGAVLAGRWNYEGTALVTVGEDGQIKIW-SKTGMLRSTLAQQGTPVYSVAWGPDSEKVL 163
H GAV N + T T D K+W + +G TLA + V +V + DS +L
Sbjct: 58 HKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHI-VKTVDFTQDSNYLL 116
Query: 164 YTAGKQLIIKPL---QPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGR 220
T G+ +++ +P A+ + H I K W S + ILSA +D ++WD
Sbjct: 117 -TGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSA-DDKTVRLWDHATM 174
Query: 221 PLYNSQPHEHPITSVAWAPDGELFAV 246
S ++S+ + P+GE+ +
Sbjct: 175 TEVKSLNFNMSVSSMEYIPEGEILVI 200
Score = 34.7 bits (78), Expect = 0.35
Identities = 63/316 (19%), Positives = 106/316 (33%), Gaps = 44/316 (13%)
Query: 187 HDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGRPLYNSQPHEHPITSVAWAPDGELFAV 246
H G + N +A D KVWD+ + H+H + +V + D
Sbjct: 58 HKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLT 117
Query: 247 GSFHTLRLCDKTGWSYALEKP---------NTGSIFNIAWSIDGTQIAGACGNGHVVFAH 297
G DK Y L KP +T I W + QI A ++ H
Sbjct: 118 GG------QDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDH 171
Query: 298 VVEQHWEWKNFQVTLTKRRAMQVRNVLNDAVDLLEFRDRVIKASLNYA-HLVVSTSLQCY 356
+ NF ++++ + +L VI + A H VS
Sbjct: 172 ATMTEVKSLNFNMSVSSMEYIPEGEIL------------VITYGRSIAFHSAVSLD---- 215
Query: 357 VFSTKNWNTPIIFDLKEGTVSLILQAERHFLLVDGSSIYLYSYEGRFISSPKFPGMRTDI 416
K++ P + S L E+ FL+ G LY Y+ + S + +
Sbjct: 216 --PIKSFEAPATIN------SASLHPEKEFLVAGGEDFKLYKYD--YNSGEELESYKGHF 265
Query: 417 LNAQTVSLSNDTIAIRDKADEKIIFLFEASTGKPLGDGKFLSHKNEILEIALDQKGL--T 474
V S D +++ + L++ GK G K + + + E+A + G T
Sbjct: 266 GPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTYGLWKCVLPEEDSGELAKPKIGFPET 325
Query: 475 NDRKIAFIDKNRDLCI 490
+ ++ I CI
Sbjct: 326 TEEELEEIASENSDCI 341
>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
Length = 2627
Score = 53.5 bits (127), Expect = 7e-07
Identities = 73/274 (26%), Positives = 105/274 (38%), Gaps = 25/274 (9%)
Query: 13 HQELVSCVGWTTAEELYSCSDDHQIVKWNLLTSETTQIVKLPDDIYPIDFHWFPKSLGVK 72
HQ VS V E + S S D + W+ E T I I P++ G
Sbjct: 2147 HQSAVSAVA-AVEEHVVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCAAAMEPRAAG-- 2203
Query: 73 KQTQAESFVLTSS-DGKFHLISKLGRVEK-SVEAHCGAVLAGRWNYEGTALVTVGEDGQI 130
Q +E V+T DG L L + ++ H G V A + ++T EDG +
Sbjct: 2204 -QPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSV 2262
Query: 131 KIWSKTGMLRST-LAQQGTPVYSVAWGPDSEKVLYTAGKQLIIKPLQPNAKVLQWKAHDG 189
++W T + + V +VAW PD + +G Q L AK + G
Sbjct: 2263 RLWQVPKEADDTCIPRSSAAVTAVAWAPDGSMAV--SGNQAGELILWQEAKAVATAQAPG 2320
Query: 190 IILKVDWNSVNDL-ILSAGEDC-KYKVWDSYGRPLYNSQPHEHPI--------TSVAWAP 239
I + W+S + +LSA E +++V G N H + I TS+ WAP
Sbjct: 2321 HIGALIWSSAHTFFVLSADEKISEWQVKLRKGSAPGNLSLHLNRILQEDLGVLTSLDWAP 2380
Query: 240 DGELFAVGSFHTLRLCDKTG------WSYALEKP 267
DG + LC K G WS E P
Sbjct: 2381 DGHFLILAKADLKLLCMKPGDAPSEIWSSYTENP 2414
Score = 46.6 bits (109), Expect = 9e-05
Identities = 59/253 (23%), Positives = 98/253 (38%), Gaps = 30/253 (11%)
Query: 13 HQELVSCVGWTT-AEELYSCSDDHQIVKWNLLTSETTQIVKLPDDIYPIDFHWFPKS--- 68
H+ VSC ++T L + D ++ W++ T +T P+ H FP
Sbjct: 2060 HEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKT-----------PVLIHSFPACHRD 2108
Query: 69 -LGVKKQTQAESFVLTSSDGKFHLIS-KLGRVEKSVEAHCGAVLAGRWNYEGTALVTVGE 126
+ T+ + SSDG L + G+ H AV A E +V+V
Sbjct: 2109 WVTGCAWTKDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEEH--VVSVSR 2166
Query: 127 DGQIKIWSKTGMLRSTLAQQGTPVYSVAWG--------PDSEKVLYTAGKQLIIKPLQPN 178
DG +K+W G+ +++ P+ A P SE ++ T G + P
Sbjct: 2167 DGTLKVWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPL 2226
Query: 179 --AKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGRPLYNSQPHEHP-ITSV 235
+ H G + + + L+L+A ED ++W P +T+V
Sbjct: 2227 LVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAV 2286
Query: 236 AWAPDGELFAVGS 248
AWAPDG + G+
Sbjct: 2287 AWAPDGSMAVSGN 2299
Score = 46.2 bits (108), Expect = 1e-04
Identities = 37/116 (31%), Positives = 57/116 (49%), Gaps = 6/116 (5%)
Query: 104 AHCGAVLAGRWNYEGTALVTVGEDGQIKIWS-KTGMLRSTLAQQG-TPVYSVAWGPDSEK 161
AH G V A + + G L+T GEDG++++WS G R L +P SVA PD ++
Sbjct: 1882 AHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDR 1941
Query: 162 VL--YTAGKQLIIKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVW 215
V Y A I K + ++ Q +A D + + W S +++S ED + W
Sbjct: 1942 VAVGYRADGIRIYK-ISSGSQGAQGQALDVAVSALAWLSPK-VLVSGAEDGSLQGW 1995
Score = 41.6 bits (96), Expect = 0.003
Identities = 36/135 (26%), Positives = 59/135 (43%), Gaps = 4/135 (2%)
Query: 117 EGTALVTVGEDGQIKIWSKTGM-LRSTLAQQGTPVYSVAWG-PDSEKVLYTAGKQLIIKP 174
EG + T G I + G+ + L G + ++A+ P + + +
Sbjct: 1811 EGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWA 1870
Query: 175 LQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD-SYGRPL-YNSQPHEHPI 232
+ A++ + AH G + + +L+AGED K +VW S GRP + P
Sbjct: 1871 WREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPA 1930
Query: 233 TSVAWAPDGELFAVG 247
SVA +PDG+ AVG
Sbjct: 1931 LSVALSPDGDRVAVG 1945
Score = 41.6 bits (96), Expect = 0.003
Identities = 56/237 (23%), Positives = 91/237 (38%), Gaps = 27/237 (11%)
Query: 17 VSCVGWTTAEELYSCSDDHQIVKWNLLTSETTQIVKLPDDIYPIDFHWFPKSLGVKKQTQ 76
VS + W + + L S ++D + W L + L P+ LG+ T
Sbjct: 1972 VSALAWLSPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPV--------LGLA--TS 2021
Query: 77 AESFVLTSSDGKFHLISK--LGRVEKSVEAHCGAVLAGR--------WNYEGTALVTVGE 126
E S D L + L R K+ + CG L G ++ +G +L T G
Sbjct: 2022 QELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGR 2081
Query: 127 DGQIKIWS----KTGML-RSTLAQQGTPVYSVAWGPDSEKVLYTAGKQLIIKPLQPNAKV 181
D + W KT +L S A V AW D+ + ++ + + + ++
Sbjct: 2082 DRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSDGSVGLWDPESGQRL 2141
Query: 182 LQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGRPLYNSQPHEHPITSVAWA 238
Q+ H + V +V + ++S D KVWD G L + H PI+ A A
Sbjct: 2142 GQFLGHQSAVSAVA--AVEEHVVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCAAA 2196
Score = 31.6 bits (70), Expect = 2.9
Identities = 24/79 (30%), Positives = 36/79 (45%), Gaps = 8/79 (10%)
Query: 175 LQPNAKVLQWKAHD----GIILKVDWNSVNDLILSAGEDCKYKVWDSYGRPLYNSQPHEH 230
LQ +VLQ KAH G L D + + L C K+WD+ L +
Sbjct: 1746 LQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGG---C-LKLWDTVRGQLAFQHTYPK 1801
Query: 231 PITSVAWAPDGELFAVGSF 249
+ VA+ P+G++ A GS+
Sbjct: 1802 SLNCVAFHPEGQVIATGSW 1820
>gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]
Length = 446
Score = 53.1 bits (126), Expect = 9e-07
Identities = 47/191 (24%), Positives = 72/191 (37%), Gaps = 24/191 (12%)
Query: 101 SVEAHCGAVLAGRWNYEGTALVTVGE-DGQIKIWSKTG-----MLRSTLAQQGTPVYSVA 154
S H G A W+ T + G+ I +W+ T + + V +
Sbjct: 209 SFAGHMGEGFALDWSPRVTGRLLTGDCQKNIHLWTPTDGGSWHVDQRPFVGHTRSVEDLQ 268
Query: 155 WGPDSEKVLYTAGKQLIIKPLQPNAK------VLQWKAHDGIILKVDWNSVNDLILSAGE 208
W P V + I+ A + AHDG + + W+ +LS G+
Sbjct: 269 WSPTENTVFASCSADASIRIWDIRAAPSKACMLTTATAHDGDVNVISWSRREPFLLSGGD 328
Query: 209 DCKYKVWD----SYGRPLYNSQPHEHPITSVAWAP--DGELFAVGSFHTLRLCDKTGWSY 262
D K+WD G P+ + H P+TSV W P G A G+ H + T W
Sbjct: 329 DGALKIWDLRQFKSGSPVATFKQHVAPVTSVEWHPQDSGVFAASGADHQI-----TQWDL 383
Query: 263 ALEK-PNTGSI 272
A+E+ P G +
Sbjct: 384 AVERDPEAGDV 394
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 52.0 bits (123), Expect = 2e-06
Identities = 64/278 (23%), Positives = 112/278 (40%), Gaps = 17/278 (6%)
Query: 13 HQELVSCVGWTT-AEELYSCSDDHQIVKWNLLTSETTQIVKLPDDIYPIDFHWFPKSLGV 71
H+ V + W+ +L S + QI+ W+ T + + W P
Sbjct: 155 HRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANP 214
Query: 72 KKQTQAESFVLTSSDGKFHLI-SKLGRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQI 130
+ + A S S DG + + GR E+ + H +V RW +G L + +D I
Sbjct: 215 ECRYVASS----SKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGL-LYSASQDRTI 269
Query: 131 KIW-SKTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAG---KQLIIKPLQPNAKVLQWKA 186
K+W + G+L TL G V ++A D L T + + P + + K
Sbjct: 270 KVWRAHDGVLCRTLQGHGHWVNTMALSTDY--ALRTGAFEPAEASVNPQDLQGSLQELKE 327
Query: 187 HDGIILKVDWNSVNDLILSAGEDCKYKVWDSYG--RPLYNSQPHEHPITSVAWAPDGELF 244
+ + ++S +D +W +PL H+ I V ++PD +
Sbjct: 328 RALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIV 387
Query: 245 AVGSF-HTLRLCD-KTGWSYALEKPNTGSIFNIAWSID 280
A SF +++L D +TG A + + +++ IAWS D
Sbjct: 388 ASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSAD 425
Score = 43.9 bits (102), Expect = 6e-04
Identities = 34/133 (25%), Positives = 60/133 (45%), Gaps = 8/133 (6%)
Query: 121 LVTVGEDGQIKIWS----KTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTA-GKQLIIKPL 175
LV+ +D + +WS K + R T Q + V + PDS V + K + +
Sbjct: 344 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQ--ALINQVLFSPDSRIVASASFDKSIKLWDG 401
Query: 176 QPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGRPLYNSQP-HEHPITS 234
+ + + H + ++ W++ + L++S D KVWD + L P H + +
Sbjct: 402 RTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYA 461
Query: 235 VAWAPDGELFAVG 247
V W+PDG+ A G
Sbjct: 462 VDWSPDGQRVASG 474
Score = 43.1 bits (100), Expect = 0.001
Identities = 37/167 (22%), Positives = 66/167 (39%), Gaps = 9/167 (5%)
Query: 97 RVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQIKIWS-KTGMLRSTLAQQGTPVYSVAW 155
R S+E H AV++ ++ G L + D ++ W T T V S++W
Sbjct: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISW 164
Query: 156 GPDSEKVLYTA--GKQLIIKPLQPNAKVLQWKAHDGIILKVDWNSVN-----DLILSAGE 208
PD K+ G+ L+ P H I + W ++ + S+ +
Sbjct: 165 SPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSK 224
Query: 209 DCKYKVWD-SYGRPLYNSQPHEHPITSVAWAPDGELFAVGSFHTLRL 254
D ++WD + GR H +T + W DG L++ T+++
Sbjct: 225 DGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKV 271
Score = 41.2 bits (95), Expect = 0.004
Identities = 21/70 (30%), Positives = 32/70 (45%), Gaps = 1/70 (1%)
Query: 94 KLGRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQIKIWS-KTGMLRSTLAQQGTPVYS 152
+ G+ S+ H AV W+ + LV+ D +K+W K L L VY+
Sbjct: 402 RTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYA 461
Query: 153 VAWGPDSEKV 162
V W PD ++V
Sbjct: 462 VDWSPDGQRV 471
Score = 39.7 bits (91), Expect = 0.011
Identities = 25/92 (27%), Positives = 41/92 (44%), Gaps = 4/92 (4%)
Query: 127 DGQIKIWS-KTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAGKQLIIKPLQPNAKVLQWK 185
D IK+W +TG ++L VY +AW DS ++L + +K A+ L
Sbjct: 393 DKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADS-RLLVSGSSDSTLKVWDVKAQKLAMD 451
Query: 186 --AHDGIILKVDWNSVNDLILSAGEDCKYKVW 215
H + VDW+ + S G+D ++W
Sbjct: 452 LPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 38.9 bits (89), Expect = 0.018
Identities = 23/69 (33%), Positives = 37/69 (53%), Gaps = 2/69 (2%)
Query: 228 HEHPITSVAWAPDGELFAVGSFHT-LRLCD-KTGWSYALEKPNTGSIFNIAWSIDGTQIA 285
H + SVA++P G+ A GS T +R D T + K + + +I+WS DG ++A
Sbjct: 113 HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLA 172
Query: 286 GACGNGHVV 294
C NG ++
Sbjct: 173 SGCKNGQIL 181
Score = 32.7 bits (73), Expect = 1.3
Identities = 35/152 (23%), Positives = 63/152 (41%), Gaps = 20/152 (13%)
Query: 103 EAHCGAVLAGRWNYEGTALVTVGEDGQIKIWS-KTG-MLRSTLAQQGTPVYSVAWGPDSE 160
+ H VL+ W+ +G L + ++GQI +W TG + TLA + ++W P
Sbjct: 153 KGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEP--- 209
Query: 161 KVLYTAGKQLIIKPLQPNAKVLQW-----------KAHDGIILKVDWNSVNDLILSAGED 209
L+ + + + V W H + + W + L+ SA +D
Sbjct: 210 --LHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGG-DGLLYSASQD 266
Query: 210 CKYKVWDSYGRPLYNS-QPHEHPITSVAWAPD 240
KVW ++ L + Q H H + ++A + D
Sbjct: 267 RTIKVWRAHDGVLCRTLQGHGHWVNTMALSTD 298
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 51.6 bits (122), Expect = 3e-06
Identities = 44/186 (23%), Positives = 82/186 (44%), Gaps = 5/186 (2%)
Query: 80 FVLTSSDGKFHLISKLGRVE--KSVEAHCGAVLAGRWNYEGTALVTVGEDGQIKIWSKTG 137
F+ T+S+ K + + R S+ H V +++ +G +V+ ED IKIW T
Sbjct: 116 FLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTN 175
Query: 138 MLRSTLAQQGTPVYSVAWGPDSEKVLYTAGKQLIIK--PLQPNAKVLQWKAHDGIILKVD 195
+ S + +AG +K ++ N + ++ H G + +
Sbjct: 176 KQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCIS 235
Query: 196 WNSVNDLILSAGEDCKYKVWDSY-GRPLYNSQPHEHPITSVAWAPDGELFAVGSFHTLRL 254
++ + +++A D K+ D GR +Y Q H P+ +V+++ GELFA G T L
Sbjct: 236 FHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVL 295
Query: 255 CDKTGW 260
+T +
Sbjct: 296 LWRTNF 301
Score = 48.5 bits (114), Expect = 2e-05
Identities = 41/166 (24%), Positives = 74/166 (44%), Gaps = 6/166 (3%)
Query: 98 VEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQIKIWSKTGMLRS-TLAQQGTPVYSVAWG 156
+E+ + H A+ + + G L T D + +W+ R+ V SV +
Sbjct: 10 LERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFS 69
Query: 157 PDSEKVLYTAGKQLIIKPLQPN--AKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKV 214
P +L +A + ++ P+ K ++KAH + VD+++ + +A ED KV
Sbjct: 70 PHGN-LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKV 128
Query: 215 WDSY-GRPLYNSQPHEHPITSVAWAPDGELF-AVGSFHTLRLCDKT 258
W Y R LY+ H H + ++PDG L + T+++ D T
Sbjct: 129 WSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTT 174
>gi|153791298 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 51.2 bits (121), Expect = 4e-06
Identities = 38/144 (26%), Positives = 64/144 (44%), Gaps = 9/144 (6%)
Query: 100 KSVEAHCGAVLAGRWNYEGTALVTVGEDGQIKIWSK-TGMLRSTLAQQGTPVYSVAWGPD 158
K+++ GAV A R+N +G +T G D +K+W+ G L T + G V A D
Sbjct: 19 KTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFD 78
Query: 159 SEKVLYTAG-KQLIIKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDS 217
+ + G K +++ + V +++ H G + V +N +ILS D + WD
Sbjct: 79 NSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDC 138
Query: 218 YGRPLYNSQPHEHPITSVAWAPDG 241
R P+ ++ A DG
Sbjct: 139 RSR-------RPEPVQTLDEARDG 155
>gi|14150114 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 51.2 bits (121), Expect = 4e-06
Identities = 38/144 (26%), Positives = 64/144 (44%), Gaps = 9/144 (6%)
Query: 100 KSVEAHCGAVLAGRWNYEGTALVTVGEDGQIKIWSK-TGMLRSTLAQQGTPVYSVAWGPD 158
K+++ GAV A R+N +G +T G D +K+W+ G L T + G V A D
Sbjct: 19 KTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFD 78
Query: 159 SEKVLYTAG-KQLIIKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDS 217
+ + G K +++ + V +++ H G + V +N +ILS D + WD
Sbjct: 79 NSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDC 138
Query: 218 YGRPLYNSQPHEHPITSVAWAPDG 241
R P+ ++ A DG
Sbjct: 139 RSR-------RPEPVQTLDEARDG 155
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 50.4 bits (119), Expect = 6e-06
Identities = 57/273 (20%), Positives = 114/273 (41%), Gaps = 39/273 (14%)
Query: 13 HQELVSCVGWT-TAEELYSCSDDHQIVKWNLLT-SETTQIVKLPDDIYPIDFH------- 63
H++ V+CV ++ ++L S S D ++ W++ S + D + ++F
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77
Query: 64 ----------WFPKSLGVKKQTQAESFVLTS----SDGKFHLISKLGRVEK--------- 100
W P G +A + + S SDG+ + + + K
Sbjct: 78 SGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137
Query: 101 --SVEAHCGAVLAGRWNYEGTALVTVGEDGQIKIWSKTGM-LRSTLAQQGTPVYSVAWGP 157
S+ H V +++ +G +V+ +D +K+W K+ + + G V V + P
Sbjct: 138 LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHP 197
Query: 158 DSEKVLYTAGKQLIIK--PLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVW 215
S + AG +K ++ + + ++ H + + ++ + +++A D K+
Sbjct: 198 -SGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKIL 256
Query: 216 DSY-GRPLYNSQPHEHPITSVAWAPDGELFAVG 247
D GR LY H+ P T+VA++ GE FA G
Sbjct: 257 DLMEGRLLYTLHGHQGPATTVAFSRTGEYFASG 289
Score = 48.1 bits (113), Expect = 3e-05
Identities = 40/158 (25%), Positives = 71/158 (44%), Gaps = 6/158 (3%)
Query: 104 AHCGAVLAGRWNYEGTALVTVGEDGQIKIW-SKTGMLRSTLAQQGTPVYSVAWGPDSEKV 162
AH V + + +G + VT +D +K+W + +L+Q V + PD ++
Sbjct: 101 AHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG-RL 159
Query: 163 LYTAGKQLIIKPLQPNAK--VLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD-SYG 219
+ +A +K +++ V + H G + VD++ I +AG D KVWD
Sbjct: 160 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 219
Query: 220 RPLYNSQPHEHPITSVAWAPDGE-LFAVGSFHTLRLCD 256
R L + Q H + +++ P G L S TL++ D
Sbjct: 220 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 257
Score = 35.8 bits (81), Expect = 0.16
Identities = 49/220 (22%), Positives = 91/220 (41%), Gaps = 17/220 (7%)
Query: 98 VEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQIKIWSKTGMLRS-TLAQQGTPVYSVAWG 156
+E+ + H AV ++ L + D + +W R+ V V +
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 157 PDSEKVLYTAGKQLIIKPLQPNAK--VLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKV 214
P S +L + + ++ PN K ++AH + V + S ++A +D KV
Sbjct: 71 P-SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKV 129
Query: 215 WDSYGRP-LYNSQPHEHPITSVAWAPDGELFAVGS-FHTLRLCDKTG----WSYALEKPN 268
W ++ + L++ H + + ++PDG L S T++L DK+ SY +
Sbjct: 130 WATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC---EH 186
Query: 269 TGSIFNIAWSIDGTQIAGACGNGHV----VFAHVVEQHWE 304
G + + + GT IA A + V V H + QH++
Sbjct: 187 GGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQ 226
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 50.4 bits (119), Expect = 6e-06
Identities = 57/273 (20%), Positives = 114/273 (41%), Gaps = 39/273 (14%)
Query: 13 HQELVSCVGWT-TAEELYSCSDDHQIVKWNLLT-SETTQIVKLPDDIYPIDFH------- 63
H++ V+CV ++ ++L S S D ++ W++ S + D + ++F
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77
Query: 64 ----------WFPKSLGVKKQTQAESFVLTS----SDGKFHLISKLGRVEK--------- 100
W P G +A + + S SDG+ + + + K
Sbjct: 78 SGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137
Query: 101 --SVEAHCGAVLAGRWNYEGTALVTVGEDGQIKIWSKTGM-LRSTLAQQGTPVYSVAWGP 157
S+ H V +++ +G +V+ +D +K+W K+ + + G V V + P
Sbjct: 138 LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHP 197
Query: 158 DSEKVLYTAGKQLIIK--PLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVW 215
S + AG +K ++ + + ++ H + + ++ + +++A D K+
Sbjct: 198 -SGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKIL 256
Query: 216 DSY-GRPLYNSQPHEHPITSVAWAPDGELFAVG 247
D GR LY H+ P T+VA++ GE FA G
Sbjct: 257 DLMEGRLLYTLHGHQGPATTVAFSRTGEYFASG 289
Score = 48.1 bits (113), Expect = 3e-05
Identities = 40/158 (25%), Positives = 71/158 (44%), Gaps = 6/158 (3%)
Query: 104 AHCGAVLAGRWNYEGTALVTVGEDGQIKIW-SKTGMLRSTLAQQGTPVYSVAWGPDSEKV 162
AH V + + +G + VT +D +K+W + +L+Q V + PD ++
Sbjct: 101 AHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG-RL 159
Query: 163 LYTAGKQLIIKPLQPNAK--VLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD-SYG 219
+ +A +K +++ V + H G + VD++ I +AG D KVWD
Sbjct: 160 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 219
Query: 220 RPLYNSQPHEHPITSVAWAPDGE-LFAVGSFHTLRLCD 256
R L + Q H + +++ P G L S TL++ D
Sbjct: 220 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 257
Score = 35.8 bits (81), Expect = 0.16
Identities = 49/220 (22%), Positives = 91/220 (41%), Gaps = 17/220 (7%)
Query: 98 VEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQIKIWSKTGMLRS-TLAQQGTPVYSVAWG 156
+E+ + H AV ++ L + D + +W R+ V V +
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 157 PDSEKVLYTAGKQLIIKPLQPNAK--VLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKV 214
P S +L + + ++ PN K ++AH + V + S ++A +D KV
Sbjct: 71 P-SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKV 129
Query: 215 WDSYGRP-LYNSQPHEHPITSVAWAPDGELFAVGS-FHTLRLCDKTG----WSYALEKPN 268
W ++ + L++ H + + ++PDG L S T++L DK+ SY +
Sbjct: 130 WATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC---EH 186
Query: 269 TGSIFNIAWSIDGTQIAGACGNGHV----VFAHVVEQHWE 304
G + + + GT IA A + V V H + QH++
Sbjct: 187 GGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQ 226
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 50.1 bits (118), Expect = 8e-06
Identities = 52/215 (24%), Positives = 91/215 (42%), Gaps = 19/215 (8%)
Query: 95 LGRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQIKIWSKTG---MLRSTLAQ-QGTPV 150
LGRV ++ C + WN GT L + G D +I+IW G + +S L++ V
Sbjct: 8 LGRVPAHPDSRCWFLA---WNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTV 64
Query: 151 YSVAWGPDSEKVLYTA--GKQLIIKPLQPNAK-VLQWKAHDGIILKVDWNSVNDLILSAG 207
VAW P + + I K Q + + V + H+ + V W +L+ +
Sbjct: 65 RKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCS 124
Query: 208 EDCKYKVWDSYGRPLYNS----QPHEHPITSVAWAPDGELFAVGSF-HTLRLC--DKTGW 260
D VW+ Y H + V W P EL A S+ T++L ++ W
Sbjct: 125 RDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDW 184
Query: 261 -SYALEKPNTGSIFNIAWSIDGTQIAGACGNGHVV 294
A + + +++++A+ G ++A +C + V
Sbjct: 185 VCCATLEGHESTVWSLAFDPSGQRLA-SCSDDRTV 218
Score = 30.0 bits (66), Expect = 8.6
Identities = 13/30 (43%), Positives = 17/30 (56%), Gaps = 2/30 (6%)
Query: 13 HQELVSCVGWTTAEE--LYSCSDDHQIVKW 40
H + V+CV W E L SCSDD ++ W
Sbjct: 302 HSQDVNCVAWNPKEPGLLASCSDDGEVAFW 331
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 49.7 bits (117), Expect = 1e-05
Identities = 44/179 (24%), Positives = 84/179 (46%), Gaps = 8/179 (4%)
Query: 75 TQAESFVLTSSDGKFHLISKLGRVEK--SVEAHCGAVLAGRWNYEGTALVTVGEDGQIKI 132
+ +SFV T+SD K + R + S+ H V +++ +G +V+ +D +K+
Sbjct: 75 SDGQSFV-TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKL 133
Query: 133 WSKTGM-LRSTLAQQGTPVYSVAWGPDSEKVLYTAGKQLIIK--PLQPNAKVLQWKAHDG 189
W K+ + + G V V + P S + AG +K ++ + + ++ H
Sbjct: 134 WDKSSRECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSA 192
Query: 190 IILKVDWNSVNDLILSAGEDCKYKVWDSY-GRPLYNSQPHEHPITSVAWAPDGELFAVG 247
+ + ++ + +++A D K+ D GR LY H+ P T+VA++ GE FA G
Sbjct: 193 AVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASG 251
Score = 48.1 bits (113), Expect = 3e-05
Identities = 40/158 (25%), Positives = 71/158 (44%), Gaps = 6/158 (3%)
Query: 104 AHCGAVLAGRWNYEGTALVTVGEDGQIKIW-SKTGMLRSTLAQQGTPVYSVAWGPDSEKV 162
AH V + + +G + VT +D +K+W + +L+Q V + PD ++
Sbjct: 63 AHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG-RL 121
Query: 163 LYTAGKQLIIKPLQPNAK--VLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD-SYG 219
+ +A +K +++ V + H G + VD++ I +AG D KVWD
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 181
Query: 220 RPLYNSQPHEHPITSVAWAPDGE-LFAVGSFHTLRLCD 256
R L + Q H + +++ P G L S TL++ D
Sbjct: 182 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 219
Score = 33.1 bits (74), Expect = 1.0
Identities = 38/158 (24%), Positives = 70/158 (44%), Gaps = 15/158 (9%)
Query: 159 SEKVLYTAGKQLIIKPLQPNAK--VLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWD 216
S +L + + ++ PN K ++AH + V + S ++A +D KVW
Sbjct: 34 SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 93
Query: 217 SYGRP-LYNSQPHEHPITSVAWAPDGELFAVGS-FHTLRLCDKTG----WSYALEKPNTG 270
++ + L++ H + + ++PDG L S T++L DK+ SY + G
Sbjct: 94 THRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC---EHGG 150
Query: 271 SIFNIAWSIDGTQIAGACGNGHV----VFAHVVEQHWE 304
+ + + GT IA A + V V H + QH++
Sbjct: 151 FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQ 188
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 49.3 bits (116), Expect = 1e-05
Identities = 51/202 (25%), Positives = 91/202 (45%), Gaps = 20/202 (9%)
Query: 118 GTALVTVGEDGQIKIWS--KTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAGKQ---LII 172
G L T G+D ++ +WS K + S L +PV SV E L AG Q + +
Sbjct: 33 GRLLATGGDDCRVNLWSINKPNCIMS-LTGHTSPVESVRLNTPEE--LIVAGSQSGSIRV 89
Query: 173 KPLQPNAKVLQ-WKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGRP-LYNSQPHEH 230
L+ AK+L+ H I +D++ + + S +D K+WD + ++ + H
Sbjct: 90 WDLEA-AKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQ 148
Query: 231 PITSVAWAPDGE-LFAVGSFHTLRLCDKTGWSYALEKP-NTGSIFNIAWSIDGTQIAGAC 288
+ + ++PDG+ L + HT++L D T E P +TG + + + + +A
Sbjct: 149 AVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGS 208
Query: 289 GNGHVVFAHVVEQHWEWKNFQV 310
+ + F W+ + FQV
Sbjct: 209 SDRTIRF-------WDLEKFQV 223
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 48.9 bits (115), Expect = 2e-05
Identities = 48/200 (24%), Positives = 92/200 (46%), Gaps = 11/200 (5%)
Query: 96 GRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQIKIWSKTGMLRSTLAQQG--TPVYSV 153
G K + HCG V + R+ + + L++ ED I+ W G +T+ QG PV+ +
Sbjct: 332 GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWD-LGSFTNTVLYQGHAYPVWDL 390
Query: 154 AWGPDSEKVLYTAGKQLIIKPLQPNAKVLQWKAHDGIILKVD---WNSVNDLILSAGEDC 210
P S + + +G L + + + G + VD ++ ++ + + D
Sbjct: 391 DISPYS--LYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDK 448
Query: 211 KYKVWDS-YGRPLYNSQPHEHPITSVAWAPDGE-LFAVGSFHTLRLCD-KTGWSYALEKP 267
++W + G + H P+ S+A++P+G+ L + G L+L D +G Y +
Sbjct: 449 TVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRG 508
Query: 268 NTGSIFNIAWSIDGTQIAGA 287
+T +I ++ +S D IA A
Sbjct: 509 HTDNITSLTFSPDSGLIASA 528
Score = 45.4 bits (106), Expect = 2e-04
Identities = 58/232 (25%), Positives = 87/232 (37%), Gaps = 53/232 (22%)
Query: 28 LYSCSDDHQIVKWNLLTSETTQIVKLPDDIYPI-DFHWFPKSLGVKKQTQAESFVLTSSD 86
L SCS+D I W+L T V YP+ D P SL + + L S D
Sbjct: 357 LLSCSEDMSIRYWDL--GSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFD 414
Query: 87 GKFHLISKLGRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQIKIWSKTGMLRSTLAQQ 146
+ L + H V +++ L T D +++WS AQQ
Sbjct: 415 RTYPL--------RIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWS---------AQQ 457
Query: 147 GTPVYSVAWGPDSEKVLYTAGKQLIIKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSA 206
G V L+T H G +L + ++ + SA
Sbjct: 458 GNSVR-----------LFT--------------------GHRGPVLSLAFSPNGKYLASA 486
Query: 207 GEDCKYKVWDSYGRPLYNS-QPHEHPITSVAWAPDGELFAVGSF-HTLRLCD 256
GED + K+WD LY + H ITS+ ++PD L A S +++R+ D
Sbjct: 487 GEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 48.5 bits (114), Expect = 2e-05
Identities = 50/206 (24%), Positives = 90/206 (43%), Gaps = 13/206 (6%)
Query: 101 SVEAHCGAVLAGRWNYEGTALVTVGEDGQIKIW-SKTGMLRSTLAQQGTPVYSVAWGPDS 159
+++ H GAV+ +N +G+ L + D + +W S+TG L + V S
Sbjct: 104 TLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRG 163
Query: 160 EKVLYTAGKQLIIKPLQPNAK-VLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSY 218
+++ T +K K +Q + +L V +N +D I+S G D KVWD
Sbjct: 164 PQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLR 223
Query: 219 GRPL-YNSQPHEHPITSVAWAPDGE-LFAVGSFHTLRLCDKTGWS--YALEKPNTGSIFN 274
L Y + H +T ++ + +G L + +T+R+ D ++ K G++ N
Sbjct: 224 QNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHN 283
Query: 275 I-------AWSIDGTQIAGACGNGHV 293
+WS DG++IA + V
Sbjct: 284 FEKNLLRCSWSPDGSKIAAGSADRFV 309
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 48.1 bits (113), Expect = 3e-05
Identities = 44/203 (21%), Positives = 88/203 (43%), Gaps = 15/203 (7%)
Query: 96 GRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQIKIWS-KTGMLRSTLAQQGTPVYSVA 154
G+ EK++ H + W+ + LV+ +D +KIW +G TL V+
Sbjct: 77 GKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCN 136
Query: 155 WGPDSEKVLYTAGKQLI-IKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYK 213
+ P S ++ + + + I ++ + AH + V +N LI+S+ D +
Sbjct: 137 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 196
Query: 214 VWDSYGRPLYNS--QPHEHPITSVAWAPDGE-LFAVGSFHTLRL-------CDKTGWSYA 263
+WD+ + P++ V ++P+G+ + A +TL+L C KT +
Sbjct: 197 IWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK 256
Query: 264 LEKPNTGSIFNIA---WSIDGTQ 283
EK + F++ W + G++
Sbjct: 257 NEKYCIFANFSVTGGKWIVSGSE 279
Score = 42.4 bits (98), Expect = 0.002
Identities = 55/251 (21%), Positives = 98/251 (39%), Gaps = 37/251 (14%)
Query: 13 HQELVSCVGWTTAEELY-SCSDDHQIVKWNLLTSETTQIVKLPDDIYPIDFHWFPKSLGV 71
H+ +S V W++ L S SDD + W++ + + + +K + Y ++ P+S +
Sbjct: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN-YVFCCNFNPQSNLI 144
Query: 72 KKQTQAESFVLTSSDGKFHLISKLGRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQIK 131
+ ES + K G+ K++ AH V A +N +G+ +V+ DG +
Sbjct: 145 VSGSFDESVRIWDV--------KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 196
Query: 132 IWSKTG--MLRSTLAQQGTPVYSVAWGPDSEKVLYTAGKQLIIKPLQPNAKVLQWKAHDG 189
IW L++ + PV V + P+ GK ++ L K+ W G
Sbjct: 197 IWDTASGQCLKTLIDDDNPPVSFVKFSPN--------GKYILAATLDNTLKL--WDYSKG 246
Query: 190 IILKVDWNSVND--------------LILSAGEDCKYKVWDSYGRPLYNS-QPHEHPITS 234
LK N+ I+S ED +W+ + + Q H + S
Sbjct: 247 KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIS 306
Query: 235 VAWAPDGELFA 245
A P + A
Sbjct: 307 TACHPTENIIA 317
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 48.1 bits (113), Expect = 3e-05
Identities = 44/203 (21%), Positives = 88/203 (43%), Gaps = 15/203 (7%)
Query: 96 GRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQIKIWS-KTGMLRSTLAQQGTPVYSVA 154
G+ EK++ H + W+ + LV+ +D +KIW +G TL V+
Sbjct: 77 GKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCN 136
Query: 155 WGPDSEKVLYTAGKQLI-IKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYK 213
+ P S ++ + + + I ++ + AH + V +N LI+S+ D +
Sbjct: 137 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 196
Query: 214 VWDSYGRPLYNS--QPHEHPITSVAWAPDGE-LFAVGSFHTLRL-------CDKTGWSYA 263
+WD+ + P++ V ++P+G+ + A +TL+L C KT +
Sbjct: 197 IWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK 256
Query: 264 LEKPNTGSIFNIA---WSIDGTQ 283
EK + F++ W + G++
Sbjct: 257 NEKYCIFANFSVTGGKWIVSGSE 279
Score = 42.4 bits (98), Expect = 0.002
Identities = 55/251 (21%), Positives = 98/251 (39%), Gaps = 37/251 (14%)
Query: 13 HQELVSCVGWTTAEELY-SCSDDHQIVKWNLLTSETTQIVKLPDDIYPIDFHWFPKSLGV 71
H+ +S V W++ L S SDD + W++ + + + +K + Y ++ P+S +
Sbjct: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN-YVFCCNFNPQSNLI 144
Query: 72 KKQTQAESFVLTSSDGKFHLISKLGRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQIK 131
+ ES + K G+ K++ AH V A +N +G+ +V+ DG +
Sbjct: 145 VSGSFDESVRIWDV--------KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 196
Query: 132 IWSKTG--MLRSTLAQQGTPVYSVAWGPDSEKVLYTAGKQLIIKPLQPNAKVLQWKAHDG 189
IW L++ + PV V + P+ GK ++ L K+ W G
Sbjct: 197 IWDTASGQCLKTLIDDDNPPVSFVKFSPN--------GKYILAATLDNTLKL--WDYSKG 246
Query: 190 IILKVDWNSVND--------------LILSAGEDCKYKVWDSYGRPLYNS-QPHEHPITS 234
LK N+ I+S ED +W+ + + Q H + S
Sbjct: 247 KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIS 306
Query: 235 VAWAPDGELFA 245
A P + A
Sbjct: 307 TACHPTENIIA 317
>gi|217330644 WD repeat domain 12 protein [Homo sapiens]
Length = 423
Score = 47.4 bits (111), Expect = 5e-05
Identities = 43/162 (26%), Positives = 76/162 (46%), Gaps = 14/162 (8%)
Query: 101 SVEAHCGAVLAGRWNYEGTALVTVGEDGQIKIWS-KTGMLRSTLAQQGTPVYS-VAWGPD 158
++ H AV + W+ + + + D I++W ++G L+STL G V++ +++ P
Sbjct: 252 TLSGHMEAVSSVLWS-DAEEICSASWDHTIRVWDVESGSLKSTLT--GNKVFNCISYSPL 308
Query: 159 SEKVLYTAGKQLIIKPLQPNAK-----VLQWKAHDGIILKVDWNSVNDLILSAGE-DCKY 212
++ L + I+ P K L +H G + V W+ ++ L +G D
Sbjct: 309 CKR-LASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIV 367
Query: 213 KVWD--SYGRPLYNSQPHEHPITSVAWAPDGELFAVGSFHTL 252
K+WD S PLY+ HE + SV W G L + G+ + L
Sbjct: 368 KLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNKL 409
Score = 35.0 bits (79), Expect = 0.27
Identities = 48/201 (23%), Positives = 71/201 (35%), Gaps = 50/201 (24%)
Query: 13 HQELVSCVGWTTAEELYSCSDDHQIVKWNLLTSETTQIVKLPDDIYPIDFHWFPKSLGV- 71
H E VS V W+ AEE+ S S DH I W++ + + I + K L
Sbjct: 256 HMEAVSSVLWSDAEEICSASWDHTIRVWDVESGSLKSTLTGNKVFNCISYSPLCKRLASG 315
Query: 72 KKQTQAESFVLTSSDGKFHLISKLGRVEKSVEAHCGAVLAGRWN-YEGTALVTVGEDGQI 130
+ + DG V S+ +H G V + +W+ L++ D +
Sbjct: 316 STDRHIRLWDPRTKDGSL--------VSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIV 367
Query: 131 KIWSKTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAGKQLIIKPLQPNAKVLQWKAHDGI 190
K+W RS A P+Y +A AH+
Sbjct: 368 KLWD----TRSCKA----PLYDLA-------------------------------AHEDK 388
Query: 191 ILKVDWNSVNDLILSAGEDCK 211
+L VDW L+LS G D K
Sbjct: 389 VLSVDWTDTG-LLLSGGADNK 408
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 47.4 bits (111), Expect = 5e-05
Identities = 42/203 (20%), Positives = 88/203 (43%), Gaps = 15/203 (7%)
Query: 96 GRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQIKIWS-KTGMLRSTLAQQGTPVYSVA 154
G+ EK++ H + W+ + + LV+ +D +K+W ++G TL V+
Sbjct: 73 GKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCN 132
Query: 155 WGPDSEKVLYTAGKQLI-IKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYK 213
+ P S ++ + + + I ++ + AH + V +N LI+S D +
Sbjct: 133 FNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCR 192
Query: 214 VWDSYGRPLYNS--QPHEHPITSVAWAPDGELFAVGSF-HTLRL-------CDKTGWSYA 263
+WD+ + P++ V ++P+G+ + +TL+L C KT +
Sbjct: 193 IWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHK 252
Query: 264 LEKPNTGSIFNIA---WSIDGTQ 283
EK + F++ W + G++
Sbjct: 253 NEKYCIFANFSVTGGKWIVSGSE 275
Score = 41.2 bits (95), Expect = 0.004
Identities = 55/251 (21%), Positives = 96/251 (38%), Gaps = 37/251 (14%)
Query: 13 HQELVSCVGWTT-AEELYSCSDDHQIVKWNLLTSETTQIVKLPDDIYPIDFHWFPKSLGV 71
H +S V W++ + L S SDD + W++ + + + +K + Y ++ P S +
Sbjct: 82 HNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSN-YVFCCNFNPPSNLI 140
Query: 72 KKQTQAESFVLTSSDGKFHLISKLGRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQIK 131
+ E+ + K G+ K++ AH V A +N G+ +V+ DG +
Sbjct: 141 ISGSFDETVKIWEV--------KTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCR 192
Query: 132 IWSKTG--MLRSTLAQQGTPVYSVAWGPDSEKVLYTAGKQLIIKPLQPNAKVLQWKAHDG 189
IW L++ + PV V + P+ GK ++ L K+ W G
Sbjct: 193 IWDAASGQCLKTLVDDDNPPVSFVKFSPN--------GKYILTATLDNTLKL--WDYSRG 242
Query: 190 IILKVDWNSVND--------------LILSAGEDCKYKVWDSYGRPLYNS-QPHEHPITS 234
LK N+ I+S ED +W+ + + Q H + S
Sbjct: 243 RCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIS 302
Query: 235 VAWAPDGELFA 245
A P L A
Sbjct: 303 AACHPTENLIA 313
>gi|169403944 WD repeat domain 26 isoform b [Homo sapiens]
Length = 498
Score = 46.6 bits (109), Expect = 9e-05
Identities = 59/258 (22%), Positives = 90/258 (34%), Gaps = 75/258 (29%)
Query: 105 HCGAVLAGRWNYEGTALVTVGEDGQIKIWS---KTGMLR--STLAQQGTPVYSVAWGPDS 159
HC V +++ +GT L T +D + IW T +L+ TL V +AW PD
Sbjct: 191 HCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDD 250
Query: 160 EKVLYTAGKQLIIKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDC-KYKVWDSY 218
N L+ +DC + +W+
Sbjct: 251 ----------------------------------------NYLVACGPDDCSELWLWNVQ 270
Query: 219 GRPLYN--SQPHEHPITSVAWAPDGELFAVGSFHTLRLCDKTGWSYALEKPNTGSIFNIA 276
L SQ HE +TSVAW PDG+ F G + G Y + G++ + +
Sbjct: 271 TGELRTKMSQSHEDSLTSVAWNPDGKRFVTGG--------QRGQFYQCDL--DGNLLD-S 319
Query: 277 WSIDGTQIAGACGNGHVVFAHVVEQHWEWKNFQ----------------VTLTKRRAMQV 320
W Q +G V A Q NF+ T++K + +
Sbjct: 320 WEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMSFTISKNGRLAL 379
Query: 321 RNVLNDAVDLLEFRDRVI 338
NV V L + +DRV+
Sbjct: 380 LNVATQGVHLWDLQDRVL 397
Score = 38.5 bits (88), Expect = 0.024
Identities = 45/189 (23%), Positives = 85/189 (44%), Gaps = 16/189 (8%)
Query: 64 WFPK--SLGVKKQTQAE--SFVLTSSDGKFHLISKLGRVEKSVEAHCGAVLAGRWNYEGT 119
WF K + G K T ++ + ++ D HL+ L K++E H V W+ +
Sbjct: 196 WFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLL----KTLEGHAYGVSYIAWSPDDN 251
Query: 120 ALVTVGEDGQIKIW---SKTGMLRSTLAQ-QGTPVYSVAWGPDSEKVLYTAGKQLIIKPL 175
LV G D ++W +TG LR+ ++Q + SVAW PD ++ + T G++
Sbjct: 252 YLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFV-TGGQRGQFYQC 310
Query: 176 QPNAKVLQWKAHDGIILKVDW-NSVNDLILSAGEDCKYKVWDSYGRPLYNSQPHEHPITS 234
+ +L + +G+ ++ W S +L++ + + ++ N +HPI S
Sbjct: 311 DLDGNLLD--SWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMS 368
Query: 235 VAWAPDGEL 243
+ +G L
Sbjct: 369 FTISKNGRL 377
>gi|55743153 WD repeat domain 26 isoform a [Homo sapiens]
Length = 514
Score = 46.6 bits (109), Expect = 9e-05
Identities = 59/258 (22%), Positives = 90/258 (34%), Gaps = 75/258 (29%)
Query: 105 HCGAVLAGRWNYEGTALVTVGEDGQIKIWS---KTGMLR--STLAQQGTPVYSVAWGPDS 159
HC V +++ +GT L T +D + IW T +L+ TL V +AW PD
Sbjct: 207 HCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDD 266
Query: 160 EKVLYTAGKQLIIKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDC-KYKVWDSY 218
N L+ +DC + +W+
Sbjct: 267 ----------------------------------------NYLVACGPDDCSELWLWNVQ 286
Query: 219 GRPLYN--SQPHEHPITSVAWAPDGELFAVGSFHTLRLCDKTGWSYALEKPNTGSIFNIA 276
L SQ HE +TSVAW PDG+ F G + G Y + G++ + +
Sbjct: 287 TGELRTKMSQSHEDSLTSVAWNPDGKRFVTGG--------QRGQFYQCDL--DGNLLD-S 335
Query: 277 WSIDGTQIAGACGNGHVVFAHVVEQHWEWKNFQ----------------VTLTKRRAMQV 320
W Q +G V A Q NF+ T++K + +
Sbjct: 336 WEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMSFTISKNGRLAL 395
Query: 321 RNVLNDAVDLLEFRDRVI 338
NV V L + +DRV+
Sbjct: 396 LNVATQGVHLWDLQDRVL 413
Score = 38.5 bits (88), Expect = 0.024
Identities = 45/189 (23%), Positives = 85/189 (44%), Gaps = 16/189 (8%)
Query: 64 WFPK--SLGVKKQTQAE--SFVLTSSDGKFHLISKLGRVEKSVEAHCGAVLAGRWNYEGT 119
WF K + G K T ++ + ++ D HL+ L K++E H V W+ +
Sbjct: 212 WFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLL----KTLEGHAYGVSYIAWSPDDN 267
Query: 120 ALVTVGEDGQIKIW---SKTGMLRSTLAQ-QGTPVYSVAWGPDSEKVLYTAGKQLIIKPL 175
LV G D ++W +TG LR+ ++Q + SVAW PD ++ + T G++
Sbjct: 268 YLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFV-TGGQRGQFYQC 326
Query: 176 QPNAKVLQWKAHDGIILKVDW-NSVNDLILSAGEDCKYKVWDSYGRPLYNSQPHEHPITS 234
+ +L + +G+ ++ W S +L++ + + ++ N +HPI S
Sbjct: 327 DLDGNLLD--SWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMS 384
Query: 235 VAWAPDGEL 243
+ +G L
Sbjct: 385 FTISKNGRL 393
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,588,643
Number of Sequences: 37866
Number of extensions: 1176624
Number of successful extensions: 3680
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 71
Number of HSP's successfully gapped in prelim test: 122
Number of HSP's that attempted gapping in prelim test: 2951
Number of HSP's gapped (non-prelim): 631
length of query: 777
length of database: 18,247,518
effective HSP length: 110
effective length of query: 667
effective length of database: 14,082,258
effective search space: 9392866086
effective search space used: 9392866086
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.