Search of human proteins with 46397369

Search of human proteins with 46397369

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|46397369 leucine rich repeat containing 20 isoform 1 [Homo
sapiens]
         (184 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|46397369 leucine rich repeat containing 20 isoform 1 [Homo sa...   356   5e-99
gi|46397373 leucine rich repeat containing 20 isoform 2 [Homo sa...   237   4e-63
gi|8922644 leucine rich repeat containing 20 isoform 3 [Homo sap...   206   9e-54
gi|53729363 leucine rich repeat and sterile alpha motif containi...    65   3e-11
gi|53729361 leucine rich repeat and sterile alpha motif containi...    65   3e-11
gi|53729359 leucine rich repeat and sterile alpha motif containi...    65   3e-11
gi|45505137 podocan [Homo sapiens]                                     63   1e-10
gi|157694513 leucine-rich repeat-containing G protein-coupled re...    61   5e-10
gi|110825984 malignant fibrous histiocytoma amplified sequence 1...    60   1e-09
gi|194440719 chondroadherin-like [Homo sapiens]                        60   1e-09
gi|194394161 leucine rich repeat containing 57 [Homo sapiens]          58   4e-09
gi|37221175 PH domain and leucine rich repeat protein phosphatas...    58   5e-09
gi|95113664 leucine rich repeat containing 1 [Homo sapiens]            58   5e-09
gi|21361633 leucine rich repeat containing 40 [Homo sapiens]           58   5e-09
gi|238908508 leucine-rich repeat and death domain-containing pro...    57   7e-09
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom...    57   7e-09
gi|28872863 CCR4-NOT transcription complex, subunit 6 [Homo sapi...    55   3e-08
gi|84781739 leucine-rich repeats and transmembrane domains 2 [Ho...    55   3e-08
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]           55   3e-08
gi|45827729 scribble isoform b [Homo sapiens]                          54   6e-08
gi|45827731 scribble isoform a [Homo sapiens]                          54   6e-08
gi|167466264 leucine rich repeat containing 18 [Homo sapiens]          54   6e-08
gi|16418467 leucine-rich alpha-2-glycoprotein 1 [Homo sapiens]         54   8e-08
gi|115583679 CCR4-NOT transcription complex, subunit 6-like [Hom...    54   8e-08
gi|153792305 leucine rich repeat containing 58 [Homo sapiens]          54   8e-08
gi|14249428 leucine-rich repeats and calponin homology (CH) doma...    54   1e-07
gi|40254924 leucine rich repeat containing 59 [Homo sapiens]           53   1e-07
gi|194306623 immunoglobulin superfamily containing leucine-rich ...    53   2e-07
gi|194306621 immunoglobulin superfamily containing leucine-rich ...    53   2e-07
gi|39930401 immunoglobulin superfamily containing leucine-rich r...    53   2e-07

>gi|46397369 leucine rich repeat containing 20 isoform 1 [Homo
           sapiens]
          Length = 184

 Score =  356 bits (914), Expect = 5e-99
 Identities = 184/184 (100%), Positives = 184/184 (100%)

Query: 1   MLKKMGEAVARVARKVNETVESGSDTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANN 60
           MLKKMGEAVARVARKVNETVESGSDTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANN
Sbjct: 1   MLKKMGEAVARVARKVNETVESGSDTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANN 60

Query: 61  ELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALP 120
           ELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALP
Sbjct: 61  ELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALP 120

Query: 121 ALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAEVRVIAPPLIKFDMLMSPEGAR 180
           ALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAEVRVIAPPLIKFDMLMSPEGAR
Sbjct: 121 ALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAEVRVIAPPLIKFDMLMSPEGAR 180

Query: 181 APLP 184
           APLP
Sbjct: 181 APLP 184


>gi|46397373 leucine rich repeat containing 20 isoform 2 [Homo
           sapiens]
          Length = 134

 Score =  237 bits (605), Expect = 4e-63
 Identities = 134/184 (72%), Positives = 134/184 (72%), Gaps = 50/184 (27%)

Query: 1   MLKKMGEAVARVARKVNETVESGSDTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANN 60
           MLKKMGEAVARVARKVNETVESGSDTL                                 
Sbjct: 1   MLKKMGEAVARVARKVNETVESGSDTL--------------------------------- 27

Query: 61  ELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALP 120
                            ELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALP
Sbjct: 28  -----------------ELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALP 70

Query: 121 ALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAEVRVIAPPLIKFDMLMSPEGAR 180
           ALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAEVRVIAPPLIKFDMLMSPEGAR
Sbjct: 71  ALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAEVRVIAPPLIKFDMLMSPEGAR 130

Query: 181 APLP 184
           APLP
Sbjct: 131 APLP 134


>gi|8922644 leucine rich repeat containing 20 isoform 3 [Homo
           sapiens]
          Length = 128

 Score =  206 bits (524), Expect = 9e-54
 Identities = 121/184 (65%), Positives = 126/184 (68%), Gaps = 56/184 (30%)

Query: 1   MLKKMGEAVARVARKVNETVESGSDTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANN 60
           MLKKMGEAVARVARKVNETVESGSDTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANN
Sbjct: 1   MLKKMGEAVARVARKVNETVESGSDTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANN 60

Query: 61  ELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALP 120
           ELKSLTSKFMTTFSQLR++ +                                E+L A+P
Sbjct: 61  ELKSLTSKFMTTFSQLRDVPV--------------------------------EKLAAMP 88

Query: 121 ALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAEVRVIAPPLIKFDMLMSPEGAR 180
                                   ALRSINLRFNPLNAEVRVIAPPLIKFDMLMSPEGAR
Sbjct: 89  ------------------------ALRSINLRFNPLNAEVRVIAPPLIKFDMLMSPEGAR 124

Query: 181 APLP 184
           APLP
Sbjct: 125 APLP 128


>gi|53729363 leucine rich repeat and sterile alpha motif containing
           1 [Homo sapiens]
          Length = 723

 Score = 65.1 bits (157), Expect = 3e-11
 Identities = 42/165 (25%), Positives = 88/165 (53%), Gaps = 6/165 (3%)

Query: 3   KKMGEAVARVARKVNETVESGSDT-LDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNE 61
           K   EA  R+  ++    E+G+D  LD+++C+L   P G +   + +  ++ ++    N 
Sbjct: 9   KPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVLIVH--TNH 66

Query: 62  LKSLTSKFMTTFS--QLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTAL 119
           L SL  K  +  S   ++ L L  N L  LP ++  L  L+ +++ RNQ    P  +  L
Sbjct: 67  LTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNL 126

Query: 120 PALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAEVRVIA 164
             L+T+N+++N++ ++P + +  + +LR++N+  N +    +++A
Sbjct: 127 TQLQTLNVKDNKLKELP-DTVGELRSLRTLNISGNEIQRLPQMLA 170



 Score = 28.5 bits (62), Expect = 3.4
 Identities = 15/54 (27%), Positives = 30/54 (55%), Gaps = 1/54 (1%)

Query: 51  QIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDL 104
           Q+  + + +N+LK L    +     LR L++ GN + RLP  ++ ++ L+ + L
Sbjct: 128 QLQTLNVKDNKLKELPDT-VGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL 180


>gi|53729361 leucine rich repeat and sterile alpha motif containing
           1 [Homo sapiens]
          Length = 723

 Score = 65.1 bits (157), Expect = 3e-11
 Identities = 42/165 (25%), Positives = 88/165 (53%), Gaps = 6/165 (3%)

Query: 3   KKMGEAVARVARKVNETVESGSDT-LDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNE 61
           K   EA  R+  ++    E+G+D  LD+++C+L   P G +   + +  ++ ++    N 
Sbjct: 9   KPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVLIVH--TNH 66

Query: 62  LKSLTSKFMTTFS--QLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTAL 119
           L SL  K  +  S   ++ L L  N L  LP ++  L  L+ +++ RNQ    P  +  L
Sbjct: 67  LTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNL 126

Query: 120 PALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAEVRVIA 164
             L+T+N+++N++ ++P + +  + +LR++N+  N +    +++A
Sbjct: 127 TQLQTLNVKDNKLKELP-DTVGELRSLRTLNISGNEIQRLPQMLA 170



 Score = 28.5 bits (62), Expect = 3.4
 Identities = 15/54 (27%), Positives = 30/54 (55%), Gaps = 1/54 (1%)

Query: 51  QIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDL 104
           Q+  + + +N+LK L    +     LR L++ GN + RLP  ++ ++ L+ + L
Sbjct: 128 QLQTLNVKDNKLKELPDT-VGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL 180


>gi|53729359 leucine rich repeat and sterile alpha motif containing
           1 [Homo sapiens]
          Length = 723

 Score = 65.1 bits (157), Expect = 3e-11
 Identities = 42/165 (25%), Positives = 88/165 (53%), Gaps = 6/165 (3%)

Query: 3   KKMGEAVARVARKVNETVESGSDT-LDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNE 61
           K   EA  R+  ++    E+G+D  LD+++C+L   P G +   + +  ++ ++    N 
Sbjct: 9   KPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVLIVH--TNH 66

Query: 62  LKSLTSKFMTTFS--QLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTAL 119
           L SL  K  +  S   ++ L L  N L  LP ++  L  L+ +++ RNQ    P  +  L
Sbjct: 67  LTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNL 126

Query: 120 PALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAEVRVIA 164
             L+T+N+++N++ ++P + +  + +LR++N+  N +    +++A
Sbjct: 127 TQLQTLNVKDNKLKELP-DTVGELRSLRTLNISGNEIQRLPQMLA 170



 Score = 28.5 bits (62), Expect = 3.4
 Identities = 15/54 (27%), Positives = 30/54 (55%), Gaps = 1/54 (1%)

Query: 51  QIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDL 104
           Q+  + + +N+LK L    +     LR L++ GN + RLP  ++ ++ L+ + L
Sbjct: 128 QLQTLNVKDNKLKELPDT-VGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL 180


>gi|45505137 podocan [Homo sapiens]
          Length = 661

 Score = 63.2 bits (152), Expect = 1e-10
 Identities = 44/134 (32%), Positives = 69/134 (51%), Gaps = 12/134 (8%)

Query: 26  TLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNF 85
           +LDL+  +L + P G+ +        +H++ +  NEL +L    +   +QLREL+L  N 
Sbjct: 482 SLDLSGNRLHTLPPGLPR-------NVHVLKVKRNELAALARGALVGMAQLRELYLTSNR 534

Query: 86  LHRL---PSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEKLAA 142
           L      P     L HL+ +D++ NQ  + PE L    +LE + L+ N+I  VP     +
Sbjct: 535 LRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPE--SLEYLYLQNNKISAVPANAFDS 592

Query: 143 MPALRSINLRFNPL 156
            P L+ I LRFN L
Sbjct: 593 TPNLKGIFLRFNKL 606



 Score = 42.0 bits (97), Expect = 3e-04
 Identities = 34/119 (28%), Positives = 58/119 (48%), Gaps = 5/119 (4%)

Query: 44  VLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFL--HRLPSEVS-ALQHLK 100
           V +++   ++ + L NN+L+ +     +  S LREL+L+ N+L    L +E    L  L+
Sbjct: 280 VPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLE 339

Query: 101 AIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAE 159
            +DLS N     P  L    +L  ++LE+N I  V    L  + +L  + L  N L  +
Sbjct: 340 YLDLSSNNLSRVPAGLPR--SLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQ 396



 Score = 37.0 bits (84), Expect = 0.010
 Identities = 34/140 (24%), Positives = 56/140 (40%), Gaps = 12/140 (8%)

Query: 22  SGSDTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHL 81
           S  + LDL+   L   P G+ + L        L+ L  N ++S+ +  +T    L  L L
Sbjct: 336 SSLEYLDLSSNNLSRVPAGLPRSLV-------LLHLEKNAIRSVDANVLTPIRSLEYLLL 388

Query: 82  EGNFLHRL---PSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVE 138
             N L      P     L+ L  + L  N  +  P  L     + T+ +  N+I  +  E
Sbjct: 389 HSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPR--RVRTLMILHNQITGIGRE 446

Query: 139 KLAAMPALRSINLRFNPLNA 158
             A    L  +NL +N + +
Sbjct: 447 DFATTYFLEELNLSYNRITS 466



 Score = 36.2 bits (82), Expect = 0.016
 Identities = 23/78 (29%), Positives = 37/78 (47%), Gaps = 3/78 (3%)

Query: 97  QHLKAIDLSRNQFQD-FPEQLTALPALETINLEENEIVD--VPVEKLAAMPALRSINLRF 153
           +H   + L  NQ +  +PE+L+ L  LET+NL+ N +    +P +    +  L  + L  
Sbjct: 144 EHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLAN 203

Query: 154 NPLNAEVRVIAPPLIKFD 171
           N L    R +   LI  D
Sbjct: 204 NKLTLAPRFLPNALISVD 221



 Score = 30.4 bits (67), Expect = 0.90
 Identities = 26/105 (24%), Positives = 48/105 (45%), Gaps = 5/105 (4%)

Query: 55  ITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAID---LSRNQFQD 111
           ++L NN+L+ +  + ++   +L  L+L+ N L        A +HL  ++   L+ N+   
Sbjct: 149 LSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTL 208

Query: 112 FPEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPL 156
            P  L    AL +++   N +  +        P LRS+ L  N L
Sbjct: 209 APRFLP--NALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKL 251


>gi|157694513 leucine-rich repeat-containing G protein-coupled
           receptor 4 [Homo sapiens]
          Length = 951

 Score = 61.2 bits (147), Expect = 5e-10
 Identities = 35/107 (32%), Positives = 55/107 (51%), Gaps = 1/107 (0%)

Query: 52  IHLITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEV-SALQHLKAIDLSRNQFQ 110
           +  +TLA N++ S+     T  S L  LHL  N +  L       L +L+ +DL+ N   
Sbjct: 179 LQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLG 238

Query: 111 DFPEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLN 157
           +FP+ + ALP+L+ +    N I  +P       P LR+I+L  NPL+
Sbjct: 239 EFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLS 285



 Score = 53.9 bits (128), Expect = 8e-08
 Identities = 37/145 (25%), Positives = 71/145 (48%), Gaps = 6/145 (4%)

Query: 16  VNETVESGSDTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQ 75
           V E + + +  LD++   +   P   +K    +      + LA N+L  +  K ++   +
Sbjct: 51  VPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEE----LQLAGNDLSFIHPKALSGLKE 106

Query: 76  LRELHLEGNFLHRLPSE-VSALQHLKAIDLSRNQFQDFPE-QLTALPALETINLEENEIV 133
           L+ L L+ N L  +PSE +  L  L+++ L  N     PE     L  L  + L++N + 
Sbjct: 107 LKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLT 166

Query: 134 DVPVEKLAAMPALRSINLRFNPLNA 158
           +VPV  L+ +P L+++ L  N +++
Sbjct: 167 EVPVHPLSNLPTLQALTLALNKISS 191



 Score = 46.6 bits (109), Expect = 1e-05
 Identities = 29/110 (26%), Positives = 57/110 (51%), Gaps = 2/110 (1%)

Query: 51  QIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSE-VSALQHLKAIDLSRNQF 109
           ++ ++TL NN+LK++ S+ +   S L+ L L+ N +  +P +    L  L+ + L  N  
Sbjct: 106 ELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSL 165

Query: 110 QDFP-EQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNA 158
            + P   L+ LP L+ + L  N+I  +P      + +L  ++L  N + +
Sbjct: 166 TEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRS 215



 Score = 43.5 bits (101), Expect = 1e-04
 Identities = 31/115 (26%), Positives = 54/115 (46%), Gaps = 4/115 (3%)

Query: 47  NVSGQIHL--ITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDL 104
           N++G +HL  +TL   ++ S+ +        LR L L  N +  LPS  +    L+ I L
Sbjct: 314 NLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS-FNGCHALEEISL 372

Query: 105 SRNQFQDFPE-QLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNA 158
            RNQ     E     L +L  ++L  N I ++     A +  + ++++ FN L +
Sbjct: 373 QRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTS 427


>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
           [Homo sapiens]
          Length = 1052

 Score = 59.7 bits (143), Expect = 1e-09
 Identities = 30/102 (29%), Positives = 62/102 (60%), Gaps = 1/102 (0%)

Query: 55  ITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPE 114
           + +++N L +L ++ ++   +LR+L+L  N L  LP+++ AL HL+ +D+S N+    P+
Sbjct: 116 LDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPD 175

Query: 115 QLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPL 156
            L+ L  L T++++ N++   P  +L  + AL  +++  N L
Sbjct: 176 SLSCLSRLRTLDVDHNQLTAFP-RQLLQLVALEELDVSSNRL 216



 Score = 58.5 bits (140), Expect = 3e-09
 Identities = 36/121 (29%), Positives = 66/121 (54%), Gaps = 6/121 (4%)

Query: 27  LDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFL 86
           LD++  +L +    +   LR    ++  + L++N+L +L ++ +   + L EL +  N L
Sbjct: 116 LDVSHNRLTALGAEVVSALR----ELRKLNLSHNQLPALPAQ-LGALAHLEELDVSFNRL 170

Query: 87  HRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEKLAAMPAL 146
             LP  +S L  L+ +D+  NQ   FP QL  L ALE +++  N +  +P E ++A+ AL
Sbjct: 171 AHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLP-EDISALRAL 229

Query: 147 R 147
           +
Sbjct: 230 K 230



 Score = 56.6 bits (135), Expect = 1e-08
 Identities = 39/112 (34%), Positives = 59/112 (52%), Gaps = 6/112 (5%)

Query: 25  DTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGN 84
           + LD++  +L   P  I   LR     + ++ L+  EL +L + F    S L  L L+ N
Sbjct: 207 EELDVSSNRLRGLPEDI-SALR----ALKILWLSGAELGTLPAGFCELAS-LESLMLDNN 260

Query: 85  FLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVP 136
            L  LP++ S LQ LK ++LS N F++FP  L  L  LE + L  N++  VP
Sbjct: 261 GLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVP 312



 Score = 50.1 bits (118), Expect = 1e-06
 Identities = 35/109 (32%), Positives = 54/109 (49%), Gaps = 3/109 (2%)

Query: 50  GQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSAL-QHLKAIDLSRNQ 108
           G I  + L NN L+ +     +    LR L L  N   RLP  V+ L  HL  +D+S N+
Sbjct: 63  GDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNR 122

Query: 109 FQDF-PEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPL 156
                 E ++AL  L  +NL  N++  +P + L A+  L  +++ FN L
Sbjct: 123 LTALGAEVVSALRELRKLNLSHNQLPALPAQ-LGALAHLEELDVSFNRL 170



 Score = 42.7 bits (99), Expect = 2e-04
 Identities = 27/104 (25%), Positives = 54/104 (51%), Gaps = 2/104 (1%)

Query: 51  QIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQ 110
           ++  + + +N+L +   + +   + L EL +  N L  LP ++SAL+ LK + LS  +  
Sbjct: 182 RLRTLDVDHNQLTAFPRQLLQLVA-LEELDVSSNRLRGLPEDISALRALKILWLSGAELG 240

Query: 111 DFPEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFN 154
             P     L +LE++ L+ N +  +P +  + +  L+ +NL  N
Sbjct: 241 TLPAGFCELASLESLMLDNNGLQALPAQ-FSCLQRLKMLNLSSN 283



 Score = 42.0 bits (97), Expect = 3e-04
 Identities = 35/139 (25%), Positives = 64/139 (46%), Gaps = 7/139 (5%)

Query: 26  TLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNF 85
           TLD+   +L +FP  + +++      +  + +++N L+ L    ++    L+ L L G  
Sbjct: 185 TLDVDHNQLTAFPRQLLQLVA-----LEELDVSSNRLRGLPED-ISALRALKILWLSGAE 238

Query: 86  LHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEKLAAMPA 145
           L  LP+    L  L+++ L  N  Q  P Q + L  L+ +NL  N   + P   L  +  
Sbjct: 239 LGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPA-ALLPLAG 297

Query: 146 LRSINLRFNPLNAEVRVIA 164
           L  + L  N L +   +I+
Sbjct: 298 LEELYLSRNQLTSVPSLIS 316



 Score = 40.0 bits (92), Expect = 0.001
 Identities = 23/86 (26%), Positives = 45/86 (52%), Gaps = 1/86 (1%)

Query: 51  QIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQ 110
           ++ ++ L++N  +   +  +   + L EL+L  N L  +PS +S L  L  + L  N+ +
Sbjct: 274 RLKMLNLSSNLFEEFPAALLP-LAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIR 332

Query: 111 DFPEQLTALPALETINLEENEIVDVP 136
             P+ +  L  LE + L+ N+I  +P
Sbjct: 333 YLPDSIVELTGLEELVLQGNQIAVLP 358



 Score = 33.9 bits (76), Expect = 0.081
 Identities = 21/82 (25%), Positives = 39/82 (47%), Gaps = 1/82 (1%)

Query: 57  LANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQL 116
           L+ N+L S+ S  ++   +L  L L+ N +  LP  +  L  L+ + L  NQ    P+  
Sbjct: 303 LSRNQLTSVPS-LISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHF 361

Query: 117 TALPALETINLEENEIVDVPVE 138
             L  +    +++N ++  P E
Sbjct: 362 GQLSRVGLWKIKDNPLIQPPYE 383


>gi|194440719 chondroadherin-like [Homo sapiens]
          Length = 762

 Score = 59.7 bits (143), Expect = 1e-09
 Identities = 43/134 (32%), Positives = 64/134 (47%), Gaps = 6/134 (4%)

Query: 27  LDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFL 86
           LDL  C++     G ++ L    G++ L+ LA+N L+ L  + +     LR L LEGN L
Sbjct: 91  LDLRHCEVELVAEGAFRGL----GRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNAL 146

Query: 87  HRL-PSEVSALQHLKAIDLSRNQFQDFPEQ-LTALPALETINLEENEIVDVPVEKLAAMP 144
             L P    AL  L  ++L+ N     P      L  +  + L  N +  +  E LA +P
Sbjct: 147 EELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLP 206

Query: 145 ALRSINLRFNPLNA 158
           ALR ++L  N L A
Sbjct: 207 ALRRLSLHHNELQA 220



 Score = 44.7 bits (104), Expect = 5e-05
 Identities = 34/106 (32%), Positives = 53/106 (50%), Gaps = 6/106 (5%)

Query: 57  LANNELKSLTSKFMTTFSQLRELHLEGNFLHRL-PSEVSALQHLKAIDLSRNQFQDFPEQ 115
           L  N    +    +     L  LHL+ N + RL P ++   + L+ + LS N+  +    
Sbjct: 504 LERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEV--S 561

Query: 116 LTAL-PA--LETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNA 158
           L AL PA  LE ++L+ N++ +VP   L  +PAL  + L  NPL A
Sbjct: 562 LGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRA 607



 Score = 38.1 bits (87), Expect = 0.004
 Identities = 33/120 (27%), Positives = 51/120 (42%), Gaps = 2/120 (1%)

Query: 40  GIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPS-EVSALQH 98
           G+  V R       L+ L  N   S+          L  LHL+   +  L +  ++ L  
Sbjct: 415 GLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGR 474

Query: 99  LKAIDLSRNQFQDFPEQ-LTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLN 157
           L  + LS NQ        L   P L  + LE N  + VP   L A+P+L S++L+ N ++
Sbjct: 475 LIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVD 534



 Score = 33.1 bits (74), Expect = 0.14
 Identities = 29/119 (24%), Positives = 56/119 (47%), Gaps = 10/119 (8%)

Query: 51  QIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEV-----SALQHLKAIDLS 105
           ++  + L  N+L+ + +  +     L EL L GN L  L          +LQHL      
Sbjct: 570 ELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSG 629

Query: 106 RNQFQDFPEQLTAL-PALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAEVRVI 163
             Q    P   + L P L++++L++N++  +P   L ++  L  I+L  NP + + +++
Sbjct: 630 LEQI--CPGAFSGLGPGLQSLHLQKNQLRALPA--LPSLSQLELIDLSSNPFHCDCQLL 684


>gi|194394161 leucine rich repeat containing 57 [Homo sapiens]
          Length = 239

 Score = 58.2 bits (139), Expect = 4e-09
 Identities = 40/141 (28%), Positives = 72/141 (51%), Gaps = 7/141 (4%)

Query: 20  VESGSDT--LDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLR 77
           VE+   T    L +  L  FP  + K+  N    +  I L+NN+++SL    +  F+ L+
Sbjct: 10  VETAQKTGVFQLKDRGLTEFPADLQKLTSN----LRTIDLSNNKIESLPPLLIGKFTLLK 65

Query: 78  ELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPV 137
            L L  N L  LP E+  L+ L+ + L+ N  ++ P     L AL+T++L  N++  +P 
Sbjct: 66  SLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALP- 124

Query: 138 EKLAAMPALRSINLRFNPLNA 158
            +L ++  L  ++L  N + +
Sbjct: 125 PQLCSLRHLDVMDLSKNQIRS 145



 Score = 57.0 bits (136), Expect = 9e-09
 Identities = 46/156 (29%), Positives = 78/156 (50%), Gaps = 14/156 (8%)

Query: 18  ETVESGSDTLDLAECKLVSFP---IGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFS 74
           + + S   T+DL+  K+ S P   IG + +L+++S       L NN+L  L  + +    
Sbjct: 34  QKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLS-------LNNNKLTVLPDE-ICNLK 85

Query: 75  QLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVD 134
           +L  L L  N L  LPS    L  LK + LS NQ    P QL +L  L+ ++L +N+I  
Sbjct: 86  KLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRS 145

Query: 135 VPVEKLAAMPALRSINLRFNPLN-AEVRVIAPPLIK 169
           +P + +  +  +  +NL  N ++   V++   P +K
Sbjct: 146 IP-DSVGELQVI-ELNLNQNQISQISVKISCCPRLK 179


>gi|37221175 PH domain and leucine rich repeat protein phosphatase
           [Homo sapiens]
          Length = 1205

 Score = 57.8 bits (138), Expect = 5e-09
 Identities = 35/129 (27%), Positives = 69/129 (53%), Gaps = 6/129 (4%)

Query: 26  TLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNF 85
           +L+L+   L  FP+ +  +       +  + ++ N L+S+ +  +     L+   L+GNF
Sbjct: 183 SLNLSNNHLGDFPLAVCSI-----PTLAELNVSCNALRSVPAA-VGVMHNLQTFLLDGNF 236

Query: 86  LHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEKLAAMPA 145
           L  LP+E+  ++ L  + LS N+F D PE L  L A++ + +  N +  + ++ L  MP 
Sbjct: 237 LQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPH 296

Query: 146 LRSINLRFN 154
           ++ ++LR N
Sbjct: 297 IKHVDLRLN 305



 Score = 46.2 bits (108), Expect = 2e-05
 Identities = 30/110 (27%), Positives = 57/110 (51%), Gaps = 4/110 (3%)

Query: 48  VSGQIHL--ITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLS 105
           ++G  HL  + +A N L+S  +  M    +L E+ L GN L  +P+ +   + +  +   
Sbjct: 520 LTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAH 579

Query: 106 RNQFQDFPEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNP 155
            N  + FPE +  LP ++ ++L  NE+ +V + +    P L+ ++L  NP
Sbjct: 580 SNCIEVFPE-VMQLPEIKCVDLSCNELSEVTLPE-NLPPKLQELDLTGNP 627



 Score = 42.4 bits (98), Expect = 2e-04
 Identities = 34/124 (27%), Positives = 60/124 (48%), Gaps = 7/124 (5%)

Query: 57  LANNELKSLTSKFMTTFSQLRELHLEGNFLHRLP-SEVSALQHLKAIDLSRNQFQDFPEQ 115
           L NN L       +T    L+ LH+  N L   P S+++ L+ L+ IDLS N+ +  P  
Sbjct: 507 LTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTT 566

Query: 116 LTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAEVRV---IAPPLIKFDM 172
           +     + T+    N I   P  ++  +P ++ ++L  N L +EV +   + P L + D+
Sbjct: 567 IMNCRRMHTVIAHSNCIEVFP--EVMQLPEIKCVDLSCNEL-SEVTLPENLPPKLQELDL 623

Query: 173 LMSP 176
             +P
Sbjct: 624 TGNP 627



 Score = 32.7 bits (73), Expect = 0.18
 Identities = 25/92 (27%), Positives = 45/92 (48%), Gaps = 10/92 (10%)

Query: 74  SQLRELHLEGNFLHRLPSEVSAL---------QHLKAIDLSRNQFQDFPEQLTALPALET 124
           +QL  L + G FL  L +  + L          +L  +D+SRN+ ++ PE +     LE 
Sbjct: 350 NQLVTLDICGYFLKALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEV 409

Query: 125 INLEENEIVDVPVEKLAAMPALRSINLRFNPL 156
           +++  N+I ++P  +L    +LR +    N L
Sbjct: 410 LDIGHNQICELPA-RLFCNSSLRKLLAGHNQL 440



 Score = 30.8 bits (68), Expect = 0.69
 Identities = 18/84 (21%), Positives = 42/84 (50%), Gaps = 3/84 (3%)

Query: 55  ITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRL-PSEVSALQHLKAIDLSRNQFQDFP 113
           + ++ N +++L  + +     ++ + L  N + +L   EV  LQH+  +DL  N+  D  
Sbjct: 276 LCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLD 335

Query: 114 EQLTALPALETINLEENEIVDVPV 137
             +     +E ++ E N++V + +
Sbjct: 336 AMI--FNNIEVLHCERNQLVTLDI 357


>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
          Length = 524

 Score = 57.8 bits (138), Expect = 5e-09
 Identities = 33/112 (29%), Positives = 58/112 (51%), Gaps = 5/112 (4%)

Query: 25  DTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGN 84
           +++D   C LV  P  IY+  R++      + L  N+L+ L  +F     +LR+L L  N
Sbjct: 15  ESIDKRHCSLVYVPEEIYRYARSLEE----LLLDANQLRELPEQFFQLV-KLRKLGLSDN 69

Query: 85  FLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVP 136
            + RLP E++    L  +D+SRN+  + PE ++   AL+  +   N +  +P
Sbjct: 70  EIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLP 121



 Score = 53.5 bits (127), Expect = 1e-07
 Identities = 34/124 (27%), Positives = 66/124 (53%), Gaps = 8/124 (6%)

Query: 26  TLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNF 85
           +L+L E  L   P  + ++ R     +  + L NNE+ +L    +     L++L L+GN 
Sbjct: 155 SLELRENLLTYLPDSLTQLRR-----LEELDLGNNEIYNLPES-IGALLHLKDLWLDGNQ 208

Query: 86  LHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVP--VEKLAAM 143
           L  LP E+  L++L  +D+S N+ +  PE+++ L +L  + + +N +  +P  + KL  +
Sbjct: 209 LSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKL 268

Query: 144 PALR 147
             L+
Sbjct: 269 SILK 272



 Score = 43.9 bits (102), Expect = 8e-05
 Identities = 31/118 (26%), Positives = 56/118 (47%), Gaps = 4/118 (3%)

Query: 41  IYKVLRNVSGQIHL--ITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQH 98
           IY +  ++   +HL  + L  N+L  L  + +     L  L +  N L RLP E+S L  
Sbjct: 186 IYNLPESIGALLHLKDLWLDGNQLSELPQE-IGNLKNLLCLDVSENRLERLPEEISGLTS 244

Query: 99  LKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPL 156
           L  + +S+N  +  P+ +  L  L  + +++N +  +P E +    +L  + L  N L
Sbjct: 245 LTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLP-EAVGECESLTELVLTENQL 301



 Score = 42.4 bits (98), Expect = 2e-04
 Identities = 21/63 (33%), Positives = 36/63 (57%)

Query: 76  LRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDV 135
           L  L L  N L  LP  ++ L+ L+ +DL  N+  + PE + AL  L+ + L+ N++ ++
Sbjct: 153 LASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSEL 212

Query: 136 PVE 138
           P E
Sbjct: 213 PQE 215



 Score = 38.9 bits (89), Expect = 0.003
 Identities = 29/114 (25%), Positives = 54/114 (47%), Gaps = 10/114 (8%)

Query: 27  LDLAECKLVSFPIGIYKVLRNVSGQIHL--ITLANNELKSLTSKFMTTFSQLRELHLEGN 84
           LD++E +L   P         +SG   L  + ++ N L+++    +    +L  L ++ N
Sbjct: 225 LDVSENRLERLP-------EEISGLTSLTDLVISQNLLETIPDG-IGKLKKLSILKVDQN 276

Query: 85  FLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVE 138
            L +LP  V   + L  + L+ NQ    P+ +  L  L  +N + N++V +P E
Sbjct: 277 RLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKE 330



 Score = 35.4 bits (80), Expect = 0.028
 Identities = 32/107 (29%), Positives = 52/107 (48%), Gaps = 11/107 (10%)

Query: 27  LDLAECKLVSFP--IGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGN 84
           L L E +L++ P  IG  K L N++   + +     E+    S  +T F       +  N
Sbjct: 294 LVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCS--LTVFC------VRDN 345

Query: 85  FLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENE 131
            L R+P+EVS    L  +D++ N+    P  LTAL  L+ + L +N+
Sbjct: 346 RLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTAL-KLKALWLSDNQ 391



 Score = 34.7 bits (78), Expect = 0.048
 Identities = 26/112 (23%), Positives = 50/112 (44%), Gaps = 6/112 (5%)

Query: 27  LDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFL 86
           L +++  L + P GI K+ +     + ++ +  N L  L    +     L EL L  N L
Sbjct: 248 LVISQNLLETIPDGIGKLKK-----LSILKVDQNRLTQLPEA-VGECESLTELVLTENQL 301

Query: 87  HRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVE 138
             LP  +  L+ L  ++  RN+    P+++    +L    + +N +  +P E
Sbjct: 302 LTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAE 353


>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
          Length = 602

 Score = 57.8 bits (138), Expect = 5e-09
 Identities = 36/102 (35%), Positives = 58/102 (56%), Gaps = 1/102 (0%)

Query: 55  ITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPE 114
           + L+ N+L S  S  +    +L  L L  NFL+ LP E+ +L  L+ I+LS N+F+  PE
Sbjct: 454 VDLSFNKL-SFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPE 512

Query: 115 QLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPL 156
            L  +  LETI +  N++  V  +K+  M  L +++L+ N L
Sbjct: 513 VLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDL 554



 Score = 50.8 bits (120), Expect = 6e-07
 Identities = 37/137 (27%), Positives = 72/137 (52%), Gaps = 7/137 (5%)

Query: 22  SGSDTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHL 81
           S  + LDL+   L + P        ++S  + L  L++NELKSL ++ +    +L+ L  
Sbjct: 174 SNLEDLDLSNNHLTTVPASF----SSLSSLVRL-NLSSNELKSLPAE-INRMKRLKHLDC 227

Query: 82  EGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEKLA 141
             N L  +P E++ ++ L+ + L RN+ +  PE   +   L+ +++ EN+I  +  E L 
Sbjct: 228 NSNLLETIPPELAGMESLELLYLRRNKLRFLPE-FPSCSLLKELHVGENQIEMLEAEHLK 286

Query: 142 AMPALRSINLRFNPLNA 158
            + ++  ++LR N L +
Sbjct: 287 HLNSILVLDLRDNKLKS 303



 Score = 48.9 bits (115), Expect = 2e-06
 Identities = 37/130 (28%), Positives = 66/130 (50%), Gaps = 7/130 (5%)

Query: 27  LDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFL 86
           LD+ + +L S P  I + L N    +  + +++N+LK L  + +T    L+ L+L+ N L
Sbjct: 110 LDIHDNQLTSLPSAI-RELEN----LQKLNVSHNKLKILPEE-ITNLRNLKCLYLQHNEL 163

Query: 87  HRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEKLAAMPAL 146
             +      L +L+ +DLS N     P   ++L +L  +NL  NE+  +P E +  M  L
Sbjct: 164 TCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAE-INRMKRL 222

Query: 147 RSINLRFNPL 156
           + ++   N L
Sbjct: 223 KHLDCNSNLL 232



 Score = 47.8 bits (112), Expect = 5e-06
 Identities = 30/102 (29%), Positives = 56/102 (54%), Gaps = 2/102 (1%)

Query: 55  ITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPE 114
           + ++NN+L+SLT   +     L  L +  N L  LPS +  L++L+ +++S N+ +  PE
Sbjct: 87  LIISNNKLQSLTDD-LRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPE 145

Query: 115 QLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPL 156
           ++T L  L+ + L+ NE+  +  E    +  L  ++L  N L
Sbjct: 146 EITNLRNLKCLYLQHNELTCIS-EGFEQLSNLEDLDLSNNHL 186



 Score = 42.7 bits (99), Expect = 2e-04
 Identities = 36/120 (30%), Positives = 62/120 (51%), Gaps = 19/120 (15%)

Query: 52  IHLITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAI---DLSRNQ 108
           + L+ L  N+L+ L      + S L+ELH+  N +  L +E   L+HL +I   DL  N+
Sbjct: 245 LELLYLRRNKLRFLPE--FPSCSLLKELHVGENQIEMLEAE--HLKHLNSILVLDLRDNK 300

Query: 109 FQDFPEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRF-----NPLNAEVRVI 163
            +  P+++  L +LE ++L  N+I  +P        +L +++L+F     NPL    R I
Sbjct: 301 LKSVPDEIILLRSLERLDLSNNDISSLPY-------SLGNLHLKFLALEGNPLRTIRREI 353



 Score = 42.4 bits (98), Expect = 2e-04
 Identities = 27/110 (24%), Positives = 51/110 (46%), Gaps = 2/110 (1%)

Query: 27  LDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFL 86
           LD ++ +    P  ++  ++  S  +  I  + N+L  +  + +     + ++ L  N L
Sbjct: 404 LDYSDKQATLIPDEVFDAVK--SNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKL 461

Query: 87  HRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVP 136
             +  E+  LQ L  +DL  N     PE++ +L  L+TINL  N    +P
Sbjct: 462 SFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLP 511



 Score = 32.3 bits (72), Expect = 0.24
 Identities = 20/85 (23%), Positives = 42/85 (49%), Gaps = 5/85 (5%)

Query: 26  TLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNF 85
           T++L+  +    P  +Y++       +  I ++NN++ S+  + M     L  L L+ N 
Sbjct: 499 TINLSFNRFKMLPEVLYRIFT-----LETILISNNQVGSVDPQKMKMMENLTTLDLQNND 553

Query: 86  LHRLPSEVSALQHLKAIDLSRNQFQ 110
           L ++P E+    +L+ + L  N F+
Sbjct: 554 LLQIPPELGNCVNLRTLLLDGNPFR 578



 Score = 29.3 bits (64), Expect = 2.0
 Identities = 19/76 (25%), Positives = 37/76 (48%), Gaps = 7/76 (9%)

Query: 89  LPSE----VSALQHLKAIDLSRNQFQDFPEQL---TALPALETINLEENEIVDVPVEKLA 141
           LPSE    + A+  LK +D S  Q    P+++        + +IN  +N++ ++P   + 
Sbjct: 387 LPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVE 446

Query: 142 AMPALRSINLRFNPLN 157
               +  ++L FN L+
Sbjct: 447 LKEMVSDVDLSFNKLS 462


>gi|238908508 leucine-rich repeat and death domain-containing
           protein [Homo sapiens]
          Length = 860

 Score = 57.4 bits (137), Expect = 7e-09
 Identities = 36/136 (26%), Positives = 73/136 (53%), Gaps = 7/136 (5%)

Query: 23  GSDTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLE 82
           G + L L E  L S P  I ++L N    + ++ +++N +  +  K ++    +R+L   
Sbjct: 189 GLEILSLQENGLSSLPSEI-QLLHN----LRILNVSHNHISHIP-KEISQLGNIRQLFFY 242

Query: 83  GNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEKLAA 142
            N++   PS++  L +L+ + L +N+ +  P+ L +L  L  +NLE N++   P + L  
Sbjct: 243 NNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFP-KALCF 301

Query: 143 MPALRSINLRFNPLNA 158
           +P L S++L  N +++
Sbjct: 302 LPKLISLDLTGNLISS 317



 Score = 49.7 bits (117), Expect = 1e-06
 Identities = 32/125 (25%), Positives = 59/125 (47%), Gaps = 7/125 (5%)

Query: 27  LDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFL 86
           L+L+E KL+ F      ++      +  + L  N++K + +      S L  L L  N  
Sbjct: 515 LELSENKLLIFSEHFCSLIN-----LKYLDLGKNQIKKIPASISNMIS-LHVLILCCNKF 568

Query: 87  HRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEKLAAMPAL 146
              P E+  L++L+ +DLS NQ Q     +  L  ++ +N   N+ +  P+E L  + +L
Sbjct: 569 ETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIE-LCQLQSL 627

Query: 147 RSINL 151
             +N+
Sbjct: 628 EQLNI 632



 Score = 49.7 bits (117), Expect = 1e-06
 Identities = 33/134 (24%), Positives = 69/134 (51%), Gaps = 4/134 (2%)

Query: 23  GSDTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLE 82
           G   L+ +  + + FPI + + L+++  Q+++  +   +L  L  + ++  +QL+EL + 
Sbjct: 603 GIQKLNFSSNQFIHFPIELCQ-LQSLE-QLNISQIKGRKLTRLPGE-LSNMTQLKELDIS 659

Query: 83  GNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEKLAA 142
            N +  +P  +  L++L ++    NQ    P  L +L  L+ +NL  N +  +P   +  
Sbjct: 660 NNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALP-SAIYN 718

Query: 143 MPALRSINLRFNPL 156
           + +L+ IN   NPL
Sbjct: 719 IFSLKEINFDDNPL 732



 Score = 48.5 bits (114), Expect = 3e-06
 Identities = 33/133 (24%), Positives = 70/133 (52%), Gaps = 10/133 (7%)

Query: 27  LDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFL 86
           LDL + ++   P  I  ++      +H++ L  N+ ++   + + T   L+ L L  N L
Sbjct: 538 LDLGKNQIKKIPASISNMI-----SLHVLILCCNKFETFPRE-LCTLENLQVLDLSENQL 591

Query: 87  HRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEE---NEIVDVPVEKLAAM 143
            ++ S++  L+ ++ ++ S NQF  FP +L  L +LE +N+ +    ++  +P E L+ M
Sbjct: 592 QKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGE-LSNM 650

Query: 144 PALRSINLRFNPL 156
             L+ +++  N +
Sbjct: 651 TQLKELDISNNAI 663



 Score = 45.4 bits (106), Expect = 3e-05
 Identities = 25/89 (28%), Positives = 48/89 (53%), Gaps = 1/89 (1%)

Query: 50  GQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQF 109
           G + +++L  N+L+ +    + +   LR L+LE N L   P  +  L  L ++DL+ N  
Sbjct: 257 GNLEILSLGKNKLRHIPDT-LPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLI 315

Query: 110 QDFPEQLTALPALETINLEENEIVDVPVE 138
              P+++  L  LET+ ++ N++  + VE
Sbjct: 316 SSLPKEIRELKNLETLLMDHNKLTFLAVE 344



 Score = 44.7 bits (104), Expect = 5e-05
 Identities = 36/156 (23%), Positives = 72/156 (46%), Gaps = 31/156 (19%)

Query: 6   GEAVARVARKVNETVESGSDTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSL 65
           G  ++ + +++ E      +TL +   KL    + I+++L+     I  + LA+N+L+ +
Sbjct: 312 GNLISSLPKEIREL--KNLETLLMDHNKLTFLAVEIFQLLK-----IKELQLADNKLEVI 364

Query: 66  TSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETI 125
           + K +  F +LR L L+ N L  +P ++S    L+ + LS N+  + P+ +  L  L  +
Sbjct: 365 SHK-IENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKL 423

Query: 126 NLEENEIV-----------------------DVPVE 138
           ++  N +V                       DVP+E
Sbjct: 424 HVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIE 459



 Score = 42.7 bits (99), Expect = 2e-04
 Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 1/89 (1%)

Query: 50  GQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQF 109
           G I  +   NN +++  S  +     L  L L  N L  +P  + +L+ L+ ++L  NQ 
Sbjct: 234 GNIRQLFFYNNYIENFPSD-LECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQL 292

Query: 110 QDFPEQLTALPALETINLEENEIVDVPVE 138
             FP+ L  LP L +++L  N I  +P E
Sbjct: 293 TTFPKALCFLPKLISLDLTGNLISSLPKE 321



 Score = 39.7 bits (91), Expect = 0.001
 Identities = 26/111 (23%), Positives = 58/111 (52%), Gaps = 6/111 (5%)

Query: 26  TLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNF 85
           +LDL    + S P  I + L+N    +  + + +N+L  L  +      +++EL L  N 
Sbjct: 307 SLDLTGNLISSLPKEI-RELKN----LETLLMDHNKLTFLAVEIFQLL-KIKELQLADNK 360

Query: 86  LHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVP 136
           L  +  ++   + L+ + L +N  ++ PE+++    LE ++L +N++ ++P
Sbjct: 361 LEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELP 411



 Score = 39.7 bits (91), Expect = 0.001
 Identities = 28/110 (25%), Positives = 52/110 (47%), Gaps = 24/110 (21%)

Query: 52  IHLITLANNELKSLTSKFMTTFSQLRELHL-----------------------EGNFLHR 88
           +  ++L++N+L  L  K++   + LR+LH+                        GN +  
Sbjct: 397 LECLSLSDNKLTELP-KYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITD 455

Query: 89  LPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVE 138
           +P E+   Q +  I+LS N+   FP  L AL +L  +++  N I ++PV+
Sbjct: 456 VPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVD 505



 Score = 35.0 bits (79), Expect = 0.036
 Identities = 30/130 (23%), Positives = 61/130 (46%), Gaps = 7/130 (5%)

Query: 27  LDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFL 86
           ++L+  K++ FP+G+  +       ++ +++  N +  +      +  QL  L L  N L
Sbjct: 469 IELSYNKIMYFPLGLCAL-----DSLYYLSVNGNYISEIPVDISFS-KQLLHLELSENKL 522

Query: 87  HRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEKLAAMPAL 146
                   +L +LK +DL +NQ +  P  ++ + +L  + L  N+    P E L  +  L
Sbjct: 523 LIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRE-LCTLENL 581

Query: 147 RSINLRFNPL 156
           + ++L  N L
Sbjct: 582 QVLDLSENQL 591



 Score = 33.9 bits (76), Expect = 0.081
 Identities = 30/135 (22%), Positives = 61/135 (45%), Gaps = 3/135 (2%)

Query: 24  SDTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTS--KFMTTFSQLRELHL 81
           SD   L   +++S      + + +    +  + + N E   LT+  K +    +L  L L
Sbjct: 251 SDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDL 310

Query: 82  EGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEKLA 141
            GN +  LP E+  L++L+ + +  N+      ++  L  ++ + L +N++ +V   K+ 
Sbjct: 311 TGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKL-EVISHKIE 369

Query: 142 AMPALRSINLRFNPL 156
               LR + L  N L
Sbjct: 370 NFRELRILILDKNLL 384



 Score = 32.7 bits (73), Expect = 0.18
 Identities = 25/87 (28%), Positives = 44/87 (50%), Gaps = 3/87 (3%)

Query: 41  IYKVLRNVSGQIHLITLA--NNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQH 98
           I ++ RN+    +L++L   NN++  L    ++  + L++L+L GN L  LPS +  +  
Sbjct: 663 IREIPRNIGELRNLVSLHAYNNQISYLPPSLLS-LNDLQQLNLSGNNLTALPSAIYNIFS 721

Query: 99  LKAIDLSRNQFQDFPEQLTALPALETI 125
           LK I+   N     P ++     L TI
Sbjct: 722 LKEINFDDNPLLRPPVEICKGKQLYTI 748


>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
           sapiens]
          Length = 560

 Score = 57.4 bits (137), Expect = 7e-09
 Identities = 41/135 (30%), Positives = 65/135 (48%), Gaps = 5/135 (3%)

Query: 22  SGSDTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHL 81
           S  ++LDL+   + S  + +   L      +  + L   +LK +          L  L L
Sbjct: 94  SSLESLDLSYNPIFSSSLVVVSFLH----ALRELRLYQTDLKEIPVVIFKNLHHLELLGL 149

Query: 82  EGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEKLA 141
            GN L  LP E+     L+ I L RNQF+ FP++L  L  LE I+L+EN+I  +P E++ 
Sbjct: 150 TGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIP-EEIG 208

Query: 142 AMPALRSINLRFNPL 156
            +  L+   +  N L
Sbjct: 209 HLTGLQKFYMASNNL 223



 Score = 53.1 bits (126), Expect = 1e-07
 Identities = 28/106 (26%), Positives = 58/106 (54%), Gaps = 1/106 (0%)

Query: 46  RNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLS 105
           ++V+ +   I  +N  L ++  +  T F++L E+HLE N +  +P E+  L++++ + L 
Sbjct: 21  QHVNDRTFFIDASNQSLTAIPLEIFT-FTELEEVHLENNQIEEIPQEIQRLKNIRVLYLD 79

Query: 106 RNQFQDFPEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINL 151
           +N  +     L  L +LE+++L  N I    +  ++ + ALR + L
Sbjct: 80  KNNLRSLCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRL 125



 Score = 50.1 bits (118), Expect = 1e-06
 Identities = 37/132 (28%), Positives = 63/132 (47%), Gaps = 6/132 (4%)

Query: 27  LDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFL 86
           L L +  L   P+ I+K L +    + L+ L  N LK L  + +   ++LRE++L+ N  
Sbjct: 123 LRLYQTDLKEIPVVIFKNLHH----LELLGLTGNHLKCLPKEIVNQ-TKLREIYLKRNQF 177

Query: 87  HRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEKLAAMPAL 146
              P E+  L  L+ IDL  N+    PE++  L  L+   +  N +  +P   L     L
Sbjct: 178 EVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPA-SLCQCSQL 236

Query: 147 RSINLRFNPLNA 158
             ++L  N L++
Sbjct: 237 SVLDLSHNLLHS 248



 Score = 50.1 bits (118), Expect = 1e-06
 Identities = 38/128 (29%), Positives = 64/128 (50%), Gaps = 7/128 (5%)

Query: 27  LDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFL 86
           LDL+   L S P    ++ +        I L+ N L+ +  + +  ++ L  L+L    L
Sbjct: 239 LDLSHNLLHSIPKSFAELRKMTE-----IGLSGNRLEKVP-RLICRWTSLHLLYLGNTGL 292

Query: 87  HRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEKLAAMPAL 146
           HRL      L +L+ +DLS+N     P Q+ AL  LE + L++N+I  +P E L ++  L
Sbjct: 293 HRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSE-LGSLSKL 351

Query: 147 RSINLRFN 154
           + + L  N
Sbjct: 352 KILGLTGN 359



 Score = 48.5 bits (114), Expect = 3e-06
 Identities = 24/81 (29%), Positives = 46/81 (56%), Gaps = 1/81 (1%)

Query: 76  LRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDV 135
           L+EL++E N L  LP  + ++ +L+ +D   N  +  P+ +    AL+ + LE+N +  +
Sbjct: 400 LKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHL 459

Query: 136 PVEKLAAMPALRSINLRFNPL 156
           P E L ++  L+ + L  NP+
Sbjct: 460 P-ENLDSLVNLKVLTLMDNPM 479



 Score = 44.7 bits (104), Expect = 5e-05
 Identities = 29/108 (26%), Positives = 58/108 (53%), Gaps = 5/108 (4%)

Query: 52  IHLITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQD 111
           +  + L+ N L     + +     L  L L+ N + +LPSE+ +L  LK + L+ N+F  
Sbjct: 305 LRFLDLSQNHLHHCPLQ-ICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLS 363

Query: 112 FPEQLTALPALETINLEENE---IVDVPVEKLAAMPALRSINLRFNPL 156
           FPE++ +L +LE + + +++   +  VP E +  + +L+ + +  N L
Sbjct: 364 FPEEVLSLASLEKLYIGQDQGFKLTYVP-EHIRKLQSLKELYIENNHL 410



 Score = 44.3 bits (103), Expect = 6e-05
 Identities = 39/133 (29%), Positives = 70/133 (52%), Gaps = 10/133 (7%)

Query: 27  LDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFL 86
           LDL++  L   P+ I   L+N    + ++ L +N++  L S+ + + S+L+ L L GN  
Sbjct: 308 LDLSQNHLHHCPLQIC-ALKN----LEVLGLDDNKIGQLPSE-LGSLSKLKILGLTGNEF 361

Query: 87  HRLPSEVSALQHLKAIDLSRNQ---FQDFPEQLTALPALETINLEENEIVDVPVEKLAAM 143
              P EV +L  L+ + + ++Q       PE +  L +L+ + +E N +  +PV  L +M
Sbjct: 362 LSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPV-SLGSM 420

Query: 144 PALRSINLRFNPL 156
           P L  ++ R N L
Sbjct: 421 PNLEVLDCRHNLL 433



 Score = 37.0 bits (84), Expect = 0.010
 Identities = 25/85 (29%), Positives = 38/85 (44%), Gaps = 1/85 (1%)

Query: 57  LANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQL 116
           + NN L+ L    + +   L  L    N L +LP  +   Q LK + L  N     PE L
Sbjct: 405 IENNHLEYLPVS-LGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENL 463

Query: 117 TALPALETINLEENEIVDVPVEKLA 141
            +L  L+ + L +N + + P E  A
Sbjct: 464 DSLVNLKVLTLMDNPMEEPPKEVCA 488



 Score = 34.7 bits (78), Expect = 0.048
 Identities = 20/85 (23%), Positives = 39/85 (45%), Gaps = 1/85 (1%)

Query: 52  IHLITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQD 111
           + +I L  N++ ++  + +   + L++ ++  N L  LP+ +     L  +DLS N    
Sbjct: 190 LEIIDLDENKIGAIPEE-IGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHS 248

Query: 112 FPEQLTALPALETINLEENEIVDVP 136
            P+    L  +  I L  N +  VP
Sbjct: 249 IPKSFAELRKMTEIGLSGNRLEKVP 273


>gi|28872863 CCR4-NOT transcription complex, subunit 6 [Homo
           sapiens]
          Length = 557

 Score = 55.5 bits (132), Expect = 3e-08
 Identities = 33/122 (27%), Positives = 67/122 (54%), Gaps = 11/122 (9%)

Query: 59  NNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTA 118
           + +++SL++  + + + L  LHL  N L R+PS+++ L +L  +DLS N+ +  P +L  
Sbjct: 37  SGKVRSLSAS-LWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGN 95

Query: 119 LPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAEVRVIAPPLIKFDMLMSPEG 178
           + +L  ++L  N +  +P E L  +  L+++ L+ NPL  ++          ++   P+G
Sbjct: 96  MVSLRELHLNNNLLRVLPFE-LGKLFQLQTLGLKGNPLTQDI---------LNLYQEPDG 145

Query: 179 AR 180
            R
Sbjct: 146 TR 147


>gi|84781739 leucine-rich repeats and transmembrane domains 2 [Homo
           sapiens]
          Length = 370

 Score = 55.5 bits (132), Expect = 3e-08
 Identities = 41/137 (29%), Positives = 61/137 (44%), Gaps = 2/137 (1%)

Query: 39  IGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEV-SALQ 97
           +G+  V  +V      + L NN+L +L S      S L+ L L  NFL RLP  +   L 
Sbjct: 57  LGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLT 116

Query: 98  HLKAIDLSRNQFQDFPEQLTA-LPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPL 156
           +L  + L  N  +     L    P L  ++L  N +  +P      + ALRS++LR N L
Sbjct: 117 NLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRL 176

Query: 157 NAEVRVIAPPLIKFDML 173
               R+   PL    +L
Sbjct: 177 QNLDRLTFEPLANLQLL 193


>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
          Length = 582

 Score = 55.5 bits (132), Expect = 3e-08
 Identities = 39/115 (33%), Positives = 61/115 (53%), Gaps = 4/115 (3%)

Query: 43  KVLRNVSGQIHL--ITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLK 100
           K+  +VSG + L  + L+NN LK L    +    +LREL LE N L  LP+E++ L+ L+
Sbjct: 416 KIPEDVSGLVSLEVLILSNNLLKKLPHG-LGNLRKLRELDLEENKLESLPNEIAYLKDLQ 474

Query: 101 AIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNP 155
            + L+ NQ    P  +  L  L  + L EN +  +P E++  +  L  + L  NP
Sbjct: 475 KLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLP-EEIGTLENLEELYLNDNP 528



 Score = 53.5 bits (127), Expect = 1e-07
 Identities = 41/138 (29%), Positives = 72/138 (52%), Gaps = 6/138 (4%)

Query: 26  TLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNF 85
           +L++   ++   P GI+   + +S     + + +N+L SL   F  T++ + EL+L  N 
Sbjct: 359 SLNMEHNRINKIPFGIFSRAKVLSK----LNMKDNQLTSLPLDF-GTWTSMVELNLATNQ 413

Query: 86  LHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEKLAAMPA 145
           L ++P +VS L  L+ + LS N  +  P  L  L  L  ++LEEN++  +P E +A +  
Sbjct: 414 LTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNE-IAYLKD 472

Query: 146 LRSINLRFNPLNAEVRVI 163
           L+ + L  N L    R I
Sbjct: 473 LQKLVLTNNQLTTLPRGI 490



 Score = 53.1 bits (126), Expect = 1e-07
 Identities = 48/175 (27%), Positives = 76/175 (43%), Gaps = 31/175 (17%)

Query: 10  ARVARKVNETVESGSDTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKF 69
           A V +++N+  E  S  LDL++                    IH++  +  EL       
Sbjct: 88  AEVIKELNKCREENSMRLDLSK------------------RSIHILPSSIKEL------- 122

Query: 70  MTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEE 129
               +QL EL+L  N L  LP+EV  L +L  + LS N     P+ L  L  L  ++L  
Sbjct: 123 ----TQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRH 178

Query: 130 NEIVDVPVEKLAAMPALRSINLRFNPLNAEVRVIAPPLIKFDMLMSPEGARAPLP 184
           N++ ++P   +  + +L ++ LRFN +    + I   L K  ML   E     LP
Sbjct: 179 NKLREIP-SVVYRLDSLTTLYLRFNRITTVEKDI-KNLSKLSMLSIRENKIKQLP 231



 Score = 53.1 bits (126), Expect = 1e-07
 Identities = 45/139 (32%), Positives = 69/139 (49%), Gaps = 6/139 (4%)

Query: 19  TVESGSDTLDLAECKLVSFPIGIYKVLRNVSGQI-HLITL--ANNELKSLTSKFMTTFSQ 75
           TVE   D  +L++  ++S      K L    G++ +LITL  A+N+L+ L  K +   +Q
Sbjct: 206 TVEK--DIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLP-KEIGNCTQ 262

Query: 76  LRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDV 135
           +  L L+ N L  LP  +  L  L  + L  N+    P  L    ALE +NLE N I  +
Sbjct: 263 ITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTL 322

Query: 136 PVEKLAAMPALRSINLRFN 154
           P   L+++  L S+ L  N
Sbjct: 323 PESLLSSLVKLNSLTLARN 341



 Score = 41.2 bits (95), Expect = 5e-04
 Identities = 27/113 (23%), Positives = 53/113 (46%), Gaps = 1/113 (0%)

Query: 52  IHLITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQD 111
           I+ + + +N +  +     +    L +L+++ N L  LP +      +  ++L+ NQ   
Sbjct: 357 IYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTK 416

Query: 112 FPEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAEVRVIA 164
            PE ++ L +LE + L  N +  +P   L  +  LR ++L  N L +    IA
Sbjct: 417 IPEDVSGLVSLEVLILSNNLLKKLP-HGLGNLRKLRELDLEENKLESLPNEIA 468



 Score = 28.5 bits (62), Expect = 3.4
 Identities = 36/136 (26%), Positives = 55/136 (40%), Gaps = 27/136 (19%)

Query: 1   MLKKMGEAVARVARKVNETVESGSDTLDLAECKLVSFP--IGIYKVLRNV---SGQIHLI 55
           +LKK+   +  + RK+ E        LDL E KL S P  I   K L+ +   + Q+  +
Sbjct: 436 LLKKLPHGLGNL-RKLRE--------LDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTL 486

Query: 56  TLANNELKSLTS------------KFMTTFSQLRELHLEGN-FLHRLPSEVSALQHLKAI 102
                 L +LT             + + T   L EL+L  N  LH LP E++    L  +
Sbjct: 487 PRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIM 546

Query: 103 DLSRNQFQDFPEQLTA 118
            +        P Q+ A
Sbjct: 547 SIENCPLSHLPPQIVA 562


>gi|45827729 scribble isoform b [Homo sapiens]
          Length = 1630

 Score = 54.3 bits (129), Expect = 6e-08
 Identities = 34/112 (30%), Positives = 55/112 (49%), Gaps = 5/112 (4%)

Query: 25  DTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGN 84
           +++D   C L + P  IY+  R++      + L  N+L+ L   F    + LR+L L  N
Sbjct: 15  ESVDKRHCSLQAVPEEIYRYSRSLEE----LLLDANQLRELPKPFFRLLN-LRKLGLSDN 69

Query: 85  FLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVP 136
            + RLP EV+    L  +D+SRN   + PE +    ALE  +   N +  +P
Sbjct: 70  EIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLP 121



 Score = 48.5 bits (114), Expect = 3e-06
 Identities = 32/94 (34%), Positives = 51/94 (54%), Gaps = 3/94 (3%)

Query: 47  NVSGQIHLITLA--NNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDL 104
           +V    +L+TL    N LKSL +  ++   +L +L L GN L  LP  + AL +L+ + L
Sbjct: 146 DVGNLANLVTLELRENLLKSLPAS-LSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWL 204

Query: 105 SRNQFQDFPEQLTALPALETINLEENEIVDVPVE 138
            RNQ    P +L  L  L  +++ EN + ++P E
Sbjct: 205 DRNQLSALPPELGNLRRLVCLDVSENRLEELPAE 238



 Score = 47.8 bits (112), Expect = 5e-06
 Identities = 33/111 (29%), Positives = 56/111 (50%), Gaps = 6/111 (5%)

Query: 26  TLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNF 85
           TL+L E  L S P  +  +++     +  + L  N+L+ L    +     LREL L+ N 
Sbjct: 155 TLELRENLLKSLPASLSFLVK-----LEQLDLGGNDLEVLPDT-LGALPNLRELWLDRNQ 208

Query: 86  LHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVP 136
           L  LP E+  L+ L  +D+S N+ ++ P +L  L  L  + L +N +  +P
Sbjct: 209 LSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLP 259



 Score = 32.0 bits (71), Expect = 0.31
 Identities = 21/79 (26%), Positives = 40/79 (50%), Gaps = 1/79 (1%)

Query: 57  LANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQL 116
           L  N+L +L  + +    +L  L +  N L  LP+E+  L  L  + LS+N  +  P+ +
Sbjct: 204 LDRNQLSALPPE-LGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGI 262

Query: 117 TALPALETINLEENEIVDV 135
             L  L  + +++N + +V
Sbjct: 263 GQLKQLSILKVDQNRLCEV 281


>gi|45827731 scribble isoform a [Homo sapiens]
          Length = 1655

 Score = 54.3 bits (129), Expect = 6e-08
 Identities = 34/112 (30%), Positives = 55/112 (49%), Gaps = 5/112 (4%)

Query: 25  DTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGN 84
           +++D   C L + P  IY+  R++      + L  N+L+ L   F    + LR+L L  N
Sbjct: 15  ESVDKRHCSLQAVPEEIYRYSRSLEE----LLLDANQLRELPKPFFRLLN-LRKLGLSDN 69

Query: 85  FLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVP 136
            + RLP EV+    L  +D+SRN   + PE +    ALE  +   N +  +P
Sbjct: 70  EIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLP 121



 Score = 48.5 bits (114), Expect = 3e-06
 Identities = 32/94 (34%), Positives = 51/94 (54%), Gaps = 3/94 (3%)

Query: 47  NVSGQIHLITLA--NNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDL 104
           +V    +L+TL    N LKSL +  ++   +L +L L GN L  LP  + AL +L+ + L
Sbjct: 146 DVGNLANLVTLELRENLLKSLPAS-LSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWL 204

Query: 105 SRNQFQDFPEQLTALPALETINLEENEIVDVPVE 138
            RNQ    P +L  L  L  +++ EN + ++P E
Sbjct: 205 DRNQLSALPPELGNLRRLVCLDVSENRLEELPAE 238



 Score = 47.8 bits (112), Expect = 5e-06
 Identities = 33/111 (29%), Positives = 56/111 (50%), Gaps = 6/111 (5%)

Query: 26  TLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNF 85
           TL+L E  L S P  +  +++     +  + L  N+L+ L    +     LREL L+ N 
Sbjct: 155 TLELRENLLKSLPASLSFLVK-----LEQLDLGGNDLEVLPDT-LGALPNLRELWLDRNQ 208

Query: 86  LHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVP 136
           L  LP E+  L+ L  +D+S N+ ++ P +L  L  L  + L +N +  +P
Sbjct: 209 LSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLP 259



 Score = 32.0 bits (71), Expect = 0.31
 Identities = 21/79 (26%), Positives = 40/79 (50%), Gaps = 1/79 (1%)

Query: 57  LANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQL 116
           L  N+L +L  + +    +L  L +  N L  LP+E+  L  L  + LS+N  +  P+ +
Sbjct: 204 LDRNQLSALPPE-LGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGI 262

Query: 117 TALPALETINLEENEIVDV 135
             L  L  + +++N + +V
Sbjct: 263 GQLKQLSILKVDQNRLCEV 281


>gi|167466264 leucine rich repeat containing 18 [Homo sapiens]
          Length = 261

 Score = 54.3 bits (129), Expect = 6e-08
 Identities = 39/170 (22%), Positives = 77/170 (45%), Gaps = 32/170 (18%)

Query: 11  RVARKVNETVESGSDTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFM 70
           +VAR   +    G   LDL++  + +FP  I ++       +  + L+ N ++ +    +
Sbjct: 16  KVARNCIKITFDGKKRLDLSKMGITTFPKCILRL-----SDMDELDLSRNLIRKIPDS-I 69

Query: 71  TTFSQLRELHLEGNFLHRLPS-------------------------EVSALQHLKAIDLS 105
           + F  LR L L  N++ +LP                          E+  L++++A++L 
Sbjct: 70  SKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLG 129

Query: 106 RNQFQDFPEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNP 155
            N     P  L AL  L  + L +N + ++PV  ++ +P L+ +N++ NP
Sbjct: 130 LNHLDSVPTTLGALKELHEVGLHDNLLNNIPV-SISKLPKLKKLNIKRNP 178



 Score = 50.4 bits (119), Expect = 8e-07
 Identities = 34/125 (27%), Positives = 60/125 (48%), Gaps = 10/125 (8%)

Query: 43  KVLRNVSGQIHLITLANNELKSLTSKFMTTF-------SQLRELHLEGNFLHRLPSEVSA 95
           K+   V+     IT    +   L+   +TTF       S + EL L  N + ++P  +S 
Sbjct: 12  KITLKVARNCIKITFDGKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISK 71

Query: 96  LQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVD--VPVEKLAAMPALRSINLRF 153
            Q+L+ +DL  N     PE +  + +L  +N+  N +    +PVE L  +  +R++NL  
Sbjct: 72  FQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVE-LKQLKNIRAVNLGL 130

Query: 154 NPLNA 158
           N L++
Sbjct: 131 NHLDS 135


>gi|16418467 leucine-rich alpha-2-glycoprotein 1 [Homo sapiens]
          Length = 347

 Score = 53.9 bits (128), Expect = 8e-08
 Identities = 46/160 (28%), Positives = 70/160 (43%), Gaps = 6/160 (3%)

Query: 27  LDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFL 86
           LDL    L   P G+++     S  +  + L  N+L+ L   ++     L  L L GN L
Sbjct: 121 LDLTRNALTGLPPGLFQA----SATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRL 176

Query: 87  HRLPSEVSA-LQHLKAIDLSRNQFQDFPEQLTALP-ALETINLEENEIVDVPVEKLAAMP 144
            +LP  + A    L+ +DL  NQ +  P  L   P  LE ++LE N++  +  + L   P
Sbjct: 177 RKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQP 236

Query: 145 ALRSINLRFNPLNAEVRVIAPPLIKFDMLMSPEGARAPLP 184
            LR + L  N L          L + DML     + A +P
Sbjct: 237 DLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVP 276



 Score = 37.0 bits (84), Expect = 0.010
 Identities = 32/94 (34%), Positives = 44/94 (46%), Gaps = 5/94 (5%)

Query: 26  TLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNF 85
           TLDL E +L + P  +   LR    Q+  + L  N+L+ L    +     LR L L GN 
Sbjct: 192 TLDLGENQLETLPPDL---LRGPL-QLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNK 247

Query: 86  LHRLPSEV-SALQHLKAIDLSRNQFQDFPEQLTA 118
           L R+ +     L+ L  +DLS N     PE L A
Sbjct: 248 LARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWA 281


>gi|115583679 CCR4-NOT transcription complex, subunit 6-like [Homo
           sapiens]
          Length = 555

 Score = 53.9 bits (128), Expect = 8e-08
 Identities = 32/122 (26%), Positives = 66/122 (54%), Gaps = 11/122 (9%)

Query: 59  NNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTA 118
           +  ++SL++  + + + L  LHL  N+L R+P +++ L +L  +DLS N+ +  P +L  
Sbjct: 42  SGRVRSLSTS-LWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGN 100

Query: 119 LPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAEVRVIAPPLIKFDMLMSPEG 178
           + +L  + L  N +  +P E L  +  L+++ L+ NPL+ ++          ++   P+G
Sbjct: 101 MVSLRELLLNNNLLRVLPYE-LGRLFQLQTLGLKGNPLSQDI---------LNLYQDPDG 150

Query: 179 AR 180
            R
Sbjct: 151 TR 152


>gi|153792305 leucine rich repeat containing 58 [Homo sapiens]
          Length = 371

 Score = 53.9 bits (128), Expect = 8e-08
 Identities = 33/105 (31%), Positives = 58/105 (55%), Gaps = 2/105 (1%)

Query: 52  IHLITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQD 111
           +  ++L  N+L+S+ ++ +     L  L+L GNF+  +P E+  L  L  + L  N+ Q 
Sbjct: 145 LQTLSLGGNQLQSIPAE-IENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQS 203

Query: 112 FPEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPL 156
            P QL+ L +L +++L  N +  +P E L  +  L  ++LR NPL
Sbjct: 204 IPPQLSQLHSLRSLSLHNNLLTYLPREILNLI-HLEELSLRGNPL 247



 Score = 49.7 bits (117), Expect = 1e-06
 Identities = 31/105 (29%), Positives = 59/105 (56%), Gaps = 2/105 (1%)

Query: 52  IHLITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQD 111
           + ++ L+ N  + + +  +     L+ L L GN L  +P+E+  LQ L+ + L  N  ++
Sbjct: 122 LQVLNLSGNCFQEVPASLLE-LRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKE 180

Query: 112 FPEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPL 156
            P +L  LP+L  + L +N+I  +P  +L+ + +LRS++L  N L
Sbjct: 181 IPPELGNLPSLNYLVLCDNKIQSIP-PQLSQLHSLRSLSLHNNLL 224



 Score = 27.3 bits (59), Expect = 7.6
 Identities = 24/79 (30%), Positives = 35/79 (44%), Gaps = 3/79 (3%)

Query: 76  LRELHLEGNFLHRLPSEV-SALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEI-- 132
           L  L L  N L  LP  + S   HL+ +D+S N       +L AL  L T+  + N +  
Sbjct: 46  LLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGG 105

Query: 133 VDVPVEKLAAMPALRSINL 151
                + LA  P  RS+ +
Sbjct: 106 PSALPKGLAQSPLCRSLQV 124


>gi|14249428 leucine-rich repeats and calponin homology (CH) domain
           containing 3 [Homo sapiens]
          Length = 712

 Score = 53.5 bits (127), Expect = 1e-07
 Identities = 31/93 (33%), Positives = 50/93 (53%), Gaps = 3/93 (3%)

Query: 55  ITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPE 114
           + ++ N+L +L          L+ L    N L  LP E+  L+HL  +D+S N+ Q  P 
Sbjct: 133 LNISRNQLSTLPVHLCNL--PLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPS 190

Query: 115 QLTALPALETINLEENEIVDVPVEKLAAMPALR 147
           Q+  L AL  +N+  N +V +P E+LA +P +R
Sbjct: 191 QIGNLEALRDLNVRRNHLVHLP-EELAELPLIR 222



 Score = 40.8 bits (94), Expect = 7e-04
 Identities = 46/184 (25%), Positives = 76/184 (41%), Gaps = 30/184 (16%)

Query: 13  ARKVNETVESGSDT--LDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFM 70
           +R ++  +E  + T  L L+  KL  FP G      +         L+ N L  +  +  
Sbjct: 46  SRSLDRALEEAAVTGVLSLSGRKLREFPRG---AANHDLTDTTRADLSRNRLSEIPIE-A 101

Query: 71  TTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEEN 130
             F  L  L+L  N +  +P  +  LQ L  +++SRNQ    P  L  LP L+ +    N
Sbjct: 102 CHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIASNN 160

Query: 131 EIVDVPVE----------------------KLAAMPALRSINLRFNPL-NAEVRVIAPPL 167
           ++V +P E                      ++  + ALR +N+R N L +    +   PL
Sbjct: 161 KLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPL 220

Query: 168 IKFD 171
           I+ D
Sbjct: 221 IRLD 224



 Score = 27.3 bits (59), Expect = 7.6
 Identities = 28/108 (25%), Positives = 45/108 (41%), Gaps = 32/108 (29%)

Query: 33  KLVSFPIGIYKVLRNVSGQIHLITL--ANNELKSLTSKFMTTFSQLRELHLEGNFLHRLP 90
           KLVS P         +    HL+ L  + NE++++ S+ +     LR+L++  N L  LP
Sbjct: 161 KLVSLP-------EEIGHLRHLMELDVSCNEIQTIPSQ-IGNLEALRDLNVRRNHLVHLP 212

Query: 91  SEVSAL----------------------QHLKAIDLSRNQFQDFPEQL 116
            E++ L                      +HL+ I L  N  Q  P Q+
Sbjct: 213 EELAELPLIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQI 260


>gi|40254924 leucine rich repeat containing 59 [Homo sapiens]
          Length = 307

 Score = 53.1 bits (126), Expect = 1e-07
 Identities = 33/110 (30%), Positives = 58/110 (52%), Gaps = 1/110 (0%)

Query: 55  ITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPE 114
           + L+ ++L  +  K +    +   L L  N L  LPS+   L HL  +DLS+N+ Q  P 
Sbjct: 20  LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79

Query: 115 QLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAEVRVIA 164
               L  L+ ++L  N++V +PV   A +  L+ ++L+ NPL+  +  +A
Sbjct: 80  DFGRLVNLQHLDLLNNKLVTLPV-SFAQLKNLKWLDLKDNPLDPVLAKVA 128


>gi|194306623 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 52.8 bits (125), Expect = 2e-07
 Identities = 38/146 (26%), Positives = 71/146 (48%), Gaps = 6/146 (4%)

Query: 14  RKVNETVESGSDTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTF 73
           R+V E + +   TL L+  K+     G +  +  V+     + LA+NE++++    +   
Sbjct: 43  REVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTS----LWLAHNEVRTVEPGALAVL 98

Query: 74  SQLRELHLEGNFLHRLP-SEVSALQHLKAIDLSRNQFQDFP-EQLTALPALETINLEENE 131
           SQL+ L L  NF+   P S++  L  L+ + ++ N+    P + L ALP L ++ +  N 
Sbjct: 99  SQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNR 158

Query: 132 IVDVPVEKLAAMPALRSINLRFNPLN 157
           +  +      A+ AL  + L  NP +
Sbjct: 159 LRTLAPGTFDALSALSHLQLYHNPFH 184



 Score = 52.0 bits (123), Expect = 3e-07
 Identities = 38/130 (29%), Positives = 62/130 (47%), Gaps = 10/130 (7%)

Query: 42  YKVLRNVS----GQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRL-PSEVSAL 96
           YK LR V       +  ++L+ N++  L        +Q+  L L  N +  + P  ++ L
Sbjct: 39  YKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVL 98

Query: 97  QHLKAIDLSRNQFQDFP-EQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNP 155
             LK +DLS N    FP   L  L AL+ + +  N +  +P + L A+P LRS+ +    
Sbjct: 99  SQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRIN--- 155

Query: 156 LNAEVRVIAP 165
            N  +R +AP
Sbjct: 156 -NNRLRTLAP 164


>gi|194306621 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 52.8 bits (125), Expect = 2e-07
 Identities = 38/146 (26%), Positives = 71/146 (48%), Gaps = 6/146 (4%)

Query: 14  RKVNETVESGSDTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTF 73
           R+V E + +   TL L+  K+     G +  +  V+     + LA+NE++++    +   
Sbjct: 43  REVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTS----LWLAHNEVRTVEPGALAVL 98

Query: 74  SQLRELHLEGNFLHRLP-SEVSALQHLKAIDLSRNQFQDFP-EQLTALPALETINLEENE 131
           SQL+ L L  NF+   P S++  L  L+ + ++ N+    P + L ALP L ++ +  N 
Sbjct: 99  SQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNR 158

Query: 132 IVDVPVEKLAAMPALRSINLRFNPLN 157
           +  +      A+ AL  + L  NP +
Sbjct: 159 LRTLAPGTFDALSALSHLQLYHNPFH 184



 Score = 52.0 bits (123), Expect = 3e-07
 Identities = 38/130 (29%), Positives = 62/130 (47%), Gaps = 10/130 (7%)

Query: 42  YKVLRNVS----GQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRL-PSEVSAL 96
           YK LR V       +  ++L+ N++  L        +Q+  L L  N +  + P  ++ L
Sbjct: 39  YKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVL 98

Query: 97  QHLKAIDLSRNQFQDFP-EQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNP 155
             LK +DLS N    FP   L  L AL+ + +  N +  +P + L A+P LRS+ +    
Sbjct: 99  SQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRIN--- 155

Query: 156 LNAEVRVIAP 165
            N  +R +AP
Sbjct: 156 -NNRLRTLAP 164


>gi|39930401 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score = 52.8 bits (125), Expect = 2e-07
 Identities = 38/146 (26%), Positives = 71/146 (48%), Gaps = 6/146 (4%)

Query: 14  RKVNETVESGSDTLDLAECKLVSFPIGIYKVLRNVSGQIHLITLANNELKSLTSKFMTTF 73
           R+V E + +   TL L+  K+     G +  +  V+     + LA+NE++++    +   
Sbjct: 43  REVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTS----LWLAHNEVRTVEPGALAVL 98

Query: 74  SQLRELHLEGNFLHRLP-SEVSALQHLKAIDLSRNQFQDFP-EQLTALPALETINLEENE 131
           SQL+ L L  NF+   P S++  L  L+ + ++ N+    P + L ALP L ++ +  N 
Sbjct: 99  SQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNR 158

Query: 132 IVDVPVEKLAAMPALRSINLRFNPLN 157
           +  +      A+ AL  + L  NP +
Sbjct: 159 LRTLAPGTFDALSALSHLQLYHNPFH 184



 Score = 52.0 bits (123), Expect = 3e-07
 Identities = 38/130 (29%), Positives = 62/130 (47%), Gaps = 10/130 (7%)

Query: 42  YKVLRNVS----GQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRL-PSEVSAL 96
           YK LR V       +  ++L+ N++  L        +Q+  L L  N +  + P  ++ L
Sbjct: 39  YKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVL 98

Query: 97  QHLKAIDLSRNQFQDFP-EQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNP 155
             LK +DLS N    FP   L  L AL+ + +  N +  +P + L A+P LRS+ +    
Sbjct: 99  SQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRIN--- 155

Query: 156 LNAEVRVIAP 165
            N  +R +AP
Sbjct: 156 -NNRLRTLAP 164


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.369 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 6,000,506
Number of Sequences: 37866
Number of extensions: 232320
Number of successful extensions: 1552
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 165
Number of HSP's successfully gapped in prelim test: 84
Number of HSP's that attempted gapping in prelim test: 704
Number of HSP's gapped (non-prelim): 691
length of query: 184
length of database: 18,247,518
effective HSP length: 96
effective length of query: 88
effective length of database: 14,612,382
effective search space: 1285889616
effective search space used: 1285889616
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 58 (26.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.