Search of human proteins with 45827716

Search of human proteins with 45827716

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6
isoform b [Homo sapiens]
         (513 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6 ...  1038   0.0  
gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6...  1009   0.0  
gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]    598   e-171
gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]      586   e-167
gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]    459   e-129
gi|4758968 cytohesin 3 [Homo sapiens]                                 118   1e-26
gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]                       114   2e-25
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]                     113   4e-25
gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]                     109   7e-24
gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]                       109   7e-24
gi|4758416 golgi-specific brefeldin A resistant guanine nucleoti...   103   5e-22
gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange pr...   100   5e-21
gi|7019505 cytohesin 4 [Homo sapiens]                                  97   3e-20
gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]                  91   3e-18
gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]       89   7e-18
gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]        89   7e-18
gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange...    89   1e-17
gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]        84   2e-16
gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]        84   2e-16
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [...    68   2e-11
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]           62   1e-09
gi|67782321 spectrin beta isoform a [Homo sapiens]                     60   5e-09
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ...    59   8e-09
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]           56   7e-08
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]           55   2e-07
gi|48928044 F-box only protein 8 [Homo sapiens]                        54   3e-07
gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sap...    53   6e-07
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ...    49   1e-05
gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo ...    48   2e-05
gi|20149626 pleckstrin homology domain containing, family O memb...    45   2e-04

>gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6
           isoform b [Homo sapiens]
          Length = 513

 Score = 1038 bits (2683), Expect = 0.0
 Identities = 513/513 (100%), Positives = 513/513 (100%)

Query: 1   MGSSWCLYGCCNAGVKTTRLEAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQ 60
           MGSSWCLYGCCNAGVKTTRLEAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQ
Sbjct: 1   MGSSWCLYGCCNAGVKTTRLEAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQ 60

Query: 61  LDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERER 120
           LDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERER
Sbjct: 61  LDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERER 120

Query: 121 VLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNE 180
           VLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNE
Sbjct: 121 VLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNE 180

Query: 181 GVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRIGSTTNPF 240
           GVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRIGSTTNPF
Sbjct: 181 GVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRIGSTTNPF 240

Query: 241 LDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEK 300
           LDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEK
Sbjct: 241 LDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEK 300

Query: 301 ALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINC 360
           ALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINC
Sbjct: 301 ALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINC 360

Query: 361 VAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPP 420
           VAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPP
Sbjct: 361 VAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPP 420

Query: 421 DKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSILKEGGKELLSNDESEAAGLKKSHSSPSL 480
           DKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSILKEGGKELLSNDESEAAGLKKSHSSPSL
Sbjct: 421 DKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSILKEGGKELLSNDESEAAGLKKSHSSPSL 480

Query: 481 NPDTSPITAKVKRNVSERKDHRPETPSIKQKVT 513
           NPDTSPITAKVKRNVSERKDHRPETPSIKQKVT
Sbjct: 481 NPDTSPITAKVKRNVSERKDHRPETPSIKQKVT 513


>gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6
            isoform a [Homo sapiens]
          Length = 1047

 Score = 1009 bits (2609), Expect = 0.0
 Identities = 502/502 (100%), Positives = 502/502 (100%)

Query: 12   NAGVKTTRLEAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQLDRFKRSDVAK 71
            NAGVKTTRLEAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQLDRFKRSDVAK
Sbjct: 546  NAGVKTTRLEAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQLDRFKRSDVAK 605

Query: 72   HLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHFSNRYFY 131
            HLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHFSNRYFY
Sbjct: 606  HLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHFSNRYFY 665

Query: 132  CNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNEGVDFSKDLLKA 191
            CNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNEGVDFSKDLLKA
Sbjct: 666  CNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNEGVDFSKDLLKA 725

Query: 192  LYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRIGSTTNPFLDIPHDPNAAV 251
            LYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRIGSTTNPFLDIPHDPNAAV
Sbjct: 726  LYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRIGSTTNPFLDIPHDPNAAV 785

Query: 252  YKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAV 311
            YKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAV
Sbjct: 786  YKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAV 845

Query: 312  SVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFP 371
            SVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFP
Sbjct: 846  SVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFP 905

Query: 372  AAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDE 431
            AAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDE
Sbjct: 906  AAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDE 965

Query: 432  YKLKDHYLEFEKTRYEMYVSILKEGGKELLSNDESEAAGLKKSHSSPSLNPDTSPITAKV 491
            YKLKDHYLEFEKTRYEMYVSILKEGGKELLSNDESEAAGLKKSHSSPSLNPDTSPITAKV
Sbjct: 966  YKLKDHYLEFEKTRYEMYVSILKEGGKELLSNDESEAAGLKKSHSSPSLNPDTSPITAKV 1025

Query: 492  KRNVSERKDHRPETPSIKQKVT 513
            KRNVSERKDHRPETPSIKQKVT
Sbjct: 1026 KRNVSERKDHRPETPSIKQKVT 1047


>gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]
          Length = 771

 Score =  598 bits (1543), Expect = e-171
 Identities = 296/471 (62%), Positives = 367/471 (77%), Gaps = 11/471 (2%)

Query: 21  EAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNNEFS 80
           ++ SE+ S+E LE  + + L+NG     EAA RLA+RLY L+ F+R DVA+ LGKNNEFS
Sbjct: 284 DSDSELSSSEGLEPGSADPLANGCQGVSEAAHRLARRLYHLEGFQRCDVARQLGKNNEFS 343

Query: 81  KLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQ 140
           +LVA EYL FFDF+G+TLD +LR F KAF L+GETQERERVL HFS RY  CNPD   S+
Sbjct: 344 RLVAGEYLSFFDFSGLTLDGALRTFLKAFPLMGETQERERVLTHFSRRYCQCNPDDSTSE 403

Query: 141 DGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEK 200
           DG+H LTCA+MLLNTDLHGHNIGKKM+CQ+FIANL  +N+G DF+KDLLK LYNSIKNEK
Sbjct: 404 DGIHTLTCALMLLNTDLHGHNIGKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEK 463

Query: 201 LEWAVDDEEKKKSPSESTEEKANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARK 260
           LEWA+D++E +KS SE  ++K  GT  K ++RI    NPFLD+P   +A  YK G L RK
Sbjct: 464 LEWAIDEDELRKSLSELVDDKF-GTGTKKVTRILDGGNPFLDVPQALSATTYKHGVLTRK 522

Query: 261 IHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHALASK 320
            HADMDGK+TPRG+RGWK FYAVLKGT+LYLQKDEY+P+KALSE DLKNA+ VHHALA++
Sbjct: 523 THADMDGKRTPRGRRGWKKFYAVLKGTILYLQKDEYRPDKALSEGDLKNAIRVHHALATR 582

Query: 321 ATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKF 380
           A+DY KK NV KLKTADWRV LFQ  S EEM  WI +IN VAA+FSAP FPAA+ S KKF
Sbjct: 583 ASDYSKKSNVLKLKTADWRVFLFQAPSKEEMLSWILRINLVAAIFSAPAFPAAVSSMKKF 642

Query: 381 SRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLE 440
            RPLLP+ TT+L QEEQL+SHE+KL+Q+T ELAEHR +P ++ +K+K+ +EY+LK+HYL 
Sbjct: 643 CRPLLPSCTTRLCQEEQLRSHENKLRQLTAELAEHRCHPVERGIKSKEAEEYRLKEHYLT 702

Query: 441 FEKTRYEMYVSIL----KEGGKEL------LSNDESEAAGLKKSHSSPSLN 481
           FEK+RYE Y+ +L    K G  +L      L+  E +   L+K+HSSP+L+
Sbjct: 703 FEKSRYETYIHLLAMKIKVGSDDLERIEARLATLEGDDPSLRKTHSSPALS 753


>gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]
          Length = 1024

 Score =  586 bits (1511), Expect = e-167
 Identities = 294/491 (59%), Positives = 378/491 (76%), Gaps = 20/491 (4%)

Query: 21   EAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNNEFS 80
            ++ SE+ STE L   + + LSNG  +++EAA+RLAKRLY+LD F+++DVA+HLGKNN+FS
Sbjct: 528  DSDSELDSTERLALGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFS 587

Query: 81   KLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQ 140
            KLVA EYLKFF FTGMTLDQ+LR F K  +L+GETQERERVL HFS RYF CNP+ ++S+
Sbjct: 588  KLVAGEYLKFFVFTGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSE 647

Query: 141  DGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEK 200
            DG H LTCA+MLLNTDLHGHNIGK+MTC +FI NL+G+N+G DF ++LLKALY+SIKNEK
Sbjct: 648  DGAHTLTCALMLLNTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEK 707

Query: 201  LEWAVDDEEKKKSPSESTEEKANGTHPKTISRI----GSTTNPFLDIPHDPNAAVYKSGF 256
            L+WA+D+EE ++S SE  +      +PK I RI    GS ++PFLD+  +P AAVYK G 
Sbjct: 708  LQWAIDEEELRRSLSELADP-----NPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGA 762

Query: 257  LARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHA 316
            L RK+HAD D +KTPRGKRGWK+F+ +LKG +LYLQK+EYKP KALSE +LKNA+S+HHA
Sbjct: 763  LVRKVHADPDCRKTPRGKRGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHA 822

Query: 317  LASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGS 376
            LA++A+DY K+P+VF L+TADWRV LFQ  S E+MQ WI +IN VAA+FSAPPFPAA+ S
Sbjct: 823  LATRASDYSKRPHVFYLRTADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSS 882

Query: 377  QKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKD 436
            QKKFSRPLLP+  T+LSQEEQ+++HE+KLK + +EL EHR+    KK + K+ +E + K+
Sbjct: 883  QKKFSRPLLPSAATRLSQEEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKE 942

Query: 437  HYLEFEKTRYEMYVSI----LKEGGKEL------LSNDESEAAGLKKSHSSPSLNPDTSP 486
             YLEFEK+RY  Y ++    LK G +EL      L+   S   GL  SHSSPSL P  S 
Sbjct: 943  AYLEFEKSRYSTYAALLRVKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPKPSS 1002

Query: 487  ITAKVKRNVSE 497
               + +R+ SE
Sbjct: 1003 -QPRAQRHSSE 1012


>gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]
          Length = 1056

 Score =  459 bits (1181), Expect = e-129
 Identities = 242/487 (49%), Positives = 324/487 (66%), Gaps = 31/487 (6%)

Query: 38   ENLSNGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMT 97
            + L+NG  +N + A  LA RLY+L+ F++S+VA +L KNN+FS+ VAEEYL FF F G +
Sbjct: 576  DKLANGVRNN-KVAWNLASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQS 634

Query: 98   LDQSLRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDL 157
            LD++LR F +A  L GETQERER+L  FS R+ +CNP    S D VH LTCAIMLLNTDL
Sbjct: 635  LDRALRSFLQALVLSGETQERERILYQFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDL 694

Query: 158  HGHNIGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSES 217
            HG NIGK M+CQEFI NL G+ +G +F K+LLKALY SI++EKLEWAVD+E+  +     
Sbjct: 695  HGQNIGKSMSCQEFITNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTAR----- 749

Query: 218  TEEKANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGW 277
              EKA  + P      G  + PFL +  DP    YK G LARK+H D DGKKTP GKRGW
Sbjct: 750  -PEKAQPSLP-----AGKMSKPFLQLAQDPTVPTYKQGILARKMHQDADGKKTPWGKRGW 803

Query: 278  KTFYAVLKGTVLYLQK---DEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKLK 334
            K F+ +L+G VLY  K   D     ++L  + +   V VHH+LA+ AT Y KKP+VF+L+
Sbjct: 804  KMFHTLLRGMVLYFLKQGEDHCLEGESLVGQMVDEPVGVHHSLATPATHYTKKPHVFQLR 863

Query: 335  TADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQ 394
            TADWR+ LFQ  + +EM  WI +IN  AA  SAPPFPAA+GSQ++F RP+LP    + S 
Sbjct: 864  TADWRLYLFQAPTAKEMSSWIARINLAAATHSAPPFPAAVGSQRRFVRPILPVGPAQSSL 923

Query: 395  EEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSIL- 453
            EEQ +SHE+ L     +L + +   P+++ + ++++E++L+  YLE+EKTRYE YV +L 
Sbjct: 924  EEQHRSHENCLDAAADDLLDLQRNLPERRGRGRELEEHRLRKEYLEYEKTRYETYVQLLV 983

Query: 454  --------------KEGGKELLSNDESEAAGLKKSHSSPSLNPDTSPITAKVKRNVSERK 499
                          ++ G+E     E + + LKKSHSSPSL+ D +P TAKVKRN+SER+
Sbjct: 984  ARLHCPSDALDLWEEQLGREAGGTREPKLS-LKKSHSSPSLHQDEAPTTAKVKRNISERR 1042

Query: 500  DHRPETP 506
             +R   P
Sbjct: 1043 TYRKIIP 1049


>gi|4758968 cytohesin 3 [Homo sapiens]
          Length = 399

 Score =  118 bits (295), Expect = 1e-26
 Identities = 59/154 (38%), Positives = 96/154 (62%)

Query: 54  LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 113
           +A+ LY+ +   ++ +  +LG+ +EF+  V + +++  +F  + L Q+LR F  +F L G
Sbjct: 101 VAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPG 160

Query: 114 ETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIA 173
           E Q+ +R++  F++RY  CNP    S D  + L+ AI++LNT LH HN+  K T + FIA
Sbjct: 161 EAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIA 220

Query: 174 NLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDD 207
             +G+NEG D  ++LL+ LY SIKNE  +   DD
Sbjct: 221 MNRGINEGGDLPEELLRNLYESIKNEPFKIPEDD 254


>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
          Length = 398

 Score =  114 bits (285), Expect = 2e-25
 Identities = 97/347 (27%), Positives = 159/347 (45%), Gaps = 74/347 (21%)

Query: 54  LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 113
           +A+ LY+ +   ++ +  +LG+ +EF+  V   +++  +FT + L Q+LR F  +F L G
Sbjct: 97  IAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPG 156

Query: 114 ETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIA 173
           E Q+ +R++  F+ RY  CN     S D  + L+ AI++LNT LH  N+  K T + FIA
Sbjct: 157 EAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIA 216

Query: 174 NLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRI 233
             +G+N+G D  ++LL+ LY SIKNE  +   DD                          
Sbjct: 217 MNRGINDGGDLPEELLRNLYESIKNEPFKIPEDDG------------------------- 251

Query: 234 GSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQK 293
              T+ F     +P+    + G+L +     + G +    KR W     +L    LY   
Sbjct: 252 NDLTHTFF----NPD----REGWLLK-----LGGGRVKTWKRRW----FILTDNCLYY-- 292

Query: 294 DEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKL-------------KT-ADWR 339
            EY  +K     + +  + + + L+ +  +  KKPN F+L             KT AD R
Sbjct: 293 FEYTTDK-----EPRGIIPLEN-LSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGR 346

Query: 340 VL-------LFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKK 379
           V+            +PEE + W   I C+ A  S  PF   + ++KK
Sbjct: 347 VVEGNHTVYRISAPTPEEKEEW---IKCIKAAISRDPFYEMLAARKK 390


>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
          Length = 397

 Score =  113 bits (283), Expect = 4e-25
 Identities = 96/347 (27%), Positives = 160/347 (46%), Gaps = 75/347 (21%)

Query: 54  LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 113
           +A+ LY+ +   ++ +  +LG+ +EF+  V   +++  +FT + L Q+LR F  +F L G
Sbjct: 97  IAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPG 156

Query: 114 ETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIA 173
           E Q+ +R++  F+ RY  CN     S D  + L+ AI++LNT LH  N+  K T + FIA
Sbjct: 157 EAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIA 216

Query: 174 NLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRI 233
             +G+N+G D  ++LL+ LY SIKNE  +   DD                          
Sbjct: 217 MNRGINDGGDLPEELLRNLYESIKNEPFKIPEDDG------------------------- 251

Query: 234 GSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQK 293
              T+ F     +P+    + G+L +     + G+      + WK  + +L    LY   
Sbjct: 252 NDLTHTFF----NPD----REGWLLK-----LGGR-----VKTWKRRWFILTDNCLYY-- 291

Query: 294 DEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKL-------------KT-ADWR 339
            EY  +K     + +  + + + L+ +  +  KKPN F+L             KT AD R
Sbjct: 292 FEYTTDK-----EPRGIIPLEN-LSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGR 345

Query: 340 VL-------LFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKK 379
           V+            +PEE + W   I C+ A  S  PF   + ++KK
Sbjct: 346 VVEGNHTVYRISAPTPEEKEEW---IKCIKAAISRDPFYEMLAARKK 389


>gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
          Length = 399

 Score =  109 bits (272), Expect = 7e-24
 Identities = 54/156 (34%), Positives = 92/156 (58%)

Query: 52  KRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSL 111
           + +A+ LY+ +   ++ +  +LG+  E +  V   ++   +FT + L Q+LR F  +F L
Sbjct: 94  EEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRL 153

Query: 112 VGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEF 171
            GE Q+ +R++  F+ RY  CNP    S D  + L+ A+++LNT LH  N+  K   + F
Sbjct: 154 PGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERF 213

Query: 172 IANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDD 207
           +A  +G+NEG D  ++LL+ LY+SI+NE  +   DD
Sbjct: 214 VAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDD 249


>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
          Length = 400

 Score =  109 bits (272), Expect = 7e-24
 Identities = 54/156 (34%), Positives = 92/156 (58%)

Query: 52  KRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSL 111
           + +A+ LY+ +   ++ +  +LG+  E +  V   ++   +FT + L Q+LR F  +F L
Sbjct: 94  EEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRL 153

Query: 112 VGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEF 171
            GE Q+ +R++  F+ RY  CNP    S D  + L+ A+++LNT LH  N+  K   + F
Sbjct: 154 PGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERF 213

Query: 172 IANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDD 207
           +A  +G+NEG D  ++LL+ LY+SI+NE  +   DD
Sbjct: 214 VAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDD 249


>gi|4758416 golgi-specific brefeldin A resistant guanine nucleotide
           exchange factor 1 [Homo sapiens]
          Length = 1859

 Score =  103 bits (256), Expect = 5e-22
 Identities = 50/120 (41%), Positives = 77/120 (64%), Gaps = 3/120 (2%)

Query: 85  EEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQDGVH 144
           E ++  F F G+ LD++LR + +AF L GE    +R+L  F+ R+  CN    A+ D   
Sbjct: 765 ESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIQRLLEAFTERWMNCNGSPFANSDACF 824

Query: 145 CLTCAIMLLNTDLHGHNIGKK---MTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKL 201
            L  A+++LNTD H HN+ K+   MT +EF  NL+GVN G DF +D+L+ +Y++IKNE++
Sbjct: 825 SLAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILEDMYHAIKNEEI 884


>gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange
           protein 1 [Homo sapiens]
          Length = 1849

 Score = 99.8 bits (247), Expect = 5e-21
 Identities = 54/169 (31%), Positives = 98/169 (57%), Gaps = 4/169 (2%)

Query: 54  LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 113
           +A+ L+Q +R   + V + LG N++F+K V   Y+   DF+G     +LR F + F L G
Sbjct: 733 IAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPG 792

Query: 114 ETQERERVLIHFSNRYFYCN--PDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEF 171
           E Q+ +R++  F+ RY  CN      AS D  + L  +I++L TDLH   +  KMT +++
Sbjct: 793 EAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQY 852

Query: 172 IANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEE 220
           I   +G+N+  D  ++ L A+YN I  +K+  ++ + ++   P++S+++
Sbjct: 853 IKMNRGINDSKDLPEEYLSAIYNEIAGKKI--SMKETKELTIPTKSSKQ 899


>gi|7019505 cytohesin 4 [Homo sapiens]
          Length = 394

 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 48/154 (31%), Positives = 88/154 (57%)

Query: 54  LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 113
           +A+ LY+ +   ++ +  +LG+ +  +  V + ++   +F  + L Q+LR F  +F L G
Sbjct: 96  IARFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPG 155

Query: 114 ETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIA 173
           E Q+ +R++  F+ RY  CNP    S D  + L+ +I++LNT LH  N+  +   + F++
Sbjct: 156 EAQKIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVS 215

Query: 174 NLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDD 207
             +G+N G D  +D L+ L++SIK+E      DD
Sbjct: 216 MNRGINNGSDLPEDQLRNLFDSIKSEPFSIPEDD 249


>gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]
          Length = 759

 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 53/155 (34%), Positives = 90/155 (58%), Gaps = 6/155 (3%)

Query: 54  LAKRLYQLDRFKRSDVAKHLGKNN-EFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLV 112
           +A  L Q     R  + + LG +  +F++ V +  +   DF+ M LD++LR F     + 
Sbjct: 383 VAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQ 442

Query: 113 GETQERERVLIHFSNRYFYCNPDTIA---SQDGVHCLTCAIMLLNTDLHGHNI--GKKMT 167
           GE Q+ ER++  FS RY  CNP+ +    + D +  L  AI+LLNTD++  NI   +KM 
Sbjct: 443 GEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMM 502

Query: 168 CQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLE 202
            ++FI NL+GV++G D  ++L+  +Y  I+ ++L+
Sbjct: 503 LEDFIRNLRGVDDGADIPRELVVGIYERIQQKELK 537


>gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]
          Length = 1114

 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 61/198 (30%), Positives = 101/198 (51%), Gaps = 12/198 (6%)

Query: 54  LAKRLYQLDRFKRSDVAKHLG-KNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLV 112
           +A  L Q     R  + + LG +  +F++ V +  +   DF+ M LD++LR F     + 
Sbjct: 545 VAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQ 604

Query: 113 GETQERERVLIHFSNRYFYCNPDTI---ASQDGVHCLTCAIMLLNTDLHGHNI--GKKMT 167
           GE Q+ ER++  FS RY  CNP  +    + D +  L  AI+LLNTD++  N+   +KM 
Sbjct: 605 GEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMK 664

Query: 168 CQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHP 227
            ++FI NL+GV++G D  +++L  +Y  I+  +L+      E   S  +  E+   G  P
Sbjct: 665 LEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELK----TNEDHVSQVQKVEKLIVGKKP 720

Query: 228 KTISRIGSTTNPFLDIPH 245
             I  +       L +PH
Sbjct: 721 --IGSLHPGLGCVLSLPH 736


>gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]
          Length = 963

 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 61/198 (30%), Positives = 101/198 (51%), Gaps = 12/198 (6%)

Query: 54  LAKRLYQLDRFKRSDVAKHLG-KNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLV 112
           +A  L Q     R  + + LG +  +F++ V +  +   DF+ M LD++LR F     + 
Sbjct: 559 VAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQ 618

Query: 113 GETQERERVLIHFSNRYFYCNPDTI---ASQDGVHCLTCAIMLLNTDLHGHNI--GKKMT 167
           GE Q+ ER++  FS RY  CNP  +    + D +  L  AI+LLNTD++  N+   +KM 
Sbjct: 619 GEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMK 678

Query: 168 CQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHP 227
            ++FI NL+GV++G D  +++L  +Y  I+  +L+      E   S  +  E+   G  P
Sbjct: 679 LEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELK----TNEDHVSQVQKVEKLIVGKKP 734

Query: 228 KTISRIGSTTNPFLDIPH 245
             I  +       L +PH
Sbjct: 735 --IGSLHPGLGCVLSLPH 750


>gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange
           factor 2 [Homo sapiens]
          Length = 1785

 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 51/169 (30%), Positives = 92/169 (54%), Gaps = 4/169 (2%)

Query: 54  LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 113
           +A+ L+Q +R   + V   LG +  F+K V   Y+   DF       +LR F + F L G
Sbjct: 678 IAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPG 737

Query: 114 ETQERERVLIHFSNRYFYCN--PDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEF 171
           E Q+ +R++  F+ RY  CN      AS D  + L  +I++L TDLH   +  KMT +++
Sbjct: 738 EAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQY 797

Query: 172 IANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEE 220
           I   +G+N+  D  ++ L ++Y  I+ +K+  A+ + ++    ++ST++
Sbjct: 798 IKMNRGINDSKDLPEEYLSSIYEEIEGKKI--AMKETKELTIATKSTKQ 844


>gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]
          Length = 949

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 50/142 (35%), Positives = 80/142 (56%), Gaps = 6/142 (4%)

Query: 66  RSDVAKHLG-KNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIH 124
           R  + + LG +  +F++ V +  +   DF+ M LD +LR F     + GE Q+ ER++  
Sbjct: 595 RQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEA 654

Query: 125 FSNRYFYCNPDTI---ASQDGVHCLTCAIMLLNTDLHGHNI--GKKMTCQEFIANLQGVN 179
           FS RY  CNP  +    + D +  L  AI+LLNTD++  ++   +KM   +FI NL+GV+
Sbjct: 655 FSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVD 714

Query: 180 EGVDFSKDLLKALYNSIKNEKL 201
            G D  +DLL  +Y  I+  +L
Sbjct: 715 NGEDIPRDLLVGIYQRIQGREL 736


>gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]
          Length = 1488

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 50/142 (35%), Positives = 80/142 (56%), Gaps = 6/142 (4%)

Query: 66  RSDVAKHLG-KNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIH 124
           R  + + LG +  +F++ V +  +   DF+ M LD +LR F     + GE Q+ ER++  
Sbjct: 800 RQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEA 859

Query: 125 FSNRYFYCNPDTI---ASQDGVHCLTCAIMLLNTDLHGHNI--GKKMTCQEFIANLQGVN 179
           FS RY  CNP  +    + D +  L  AI+LLNTD++  ++   +KM   +FI NL+GV+
Sbjct: 860 FSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVD 919

Query: 180 EGVDFSKDLLKALYNSIKNEKL 201
            G D  +DLL  +Y  I+  +L
Sbjct: 920 NGEDIPRDLLVGIYQRIQGREL 941


>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [Homo
            sapiens]
          Length = 2564

 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 47/149 (31%), Positives = 66/149 (44%), Gaps = 8/149 (5%)

Query: 210  KKKSPSESTEEKANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKK 269
            ++  P E  E   +       ++ GS   P    P  P   V   GFL RK   D + K 
Sbjct: 2382 RRPRPREGGEGGGSRRSRSAPAQGGSAPAP----PPPPTHTVQHEGFLLRKRELDANRKS 2437

Query: 270  TPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPN 329
            +    R W + Y VL    L   KD   P    S    +  +S+H A +  A+DY+KK +
Sbjct: 2438 S---NRSWVSLYCVLSKGELGFYKDSKGPASG-STHGGEPLLSLHKATSEVASDYKKKKH 2493

Query: 330  VFKLKTADWRVLLFQTQSPEEMQGWINKI 358
            VFKL+T D    L Q +  EEM GW+  +
Sbjct: 2494 VFKLQTQDGSEFLLQAKDEEEMNGWLEAV 2522


>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
          Length = 2390

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 53/190 (27%), Positives = 83/190 (43%), Gaps = 15/190 (7%)

Query: 209  EKKKSPSESTEEKANGTHPKTISRIGSTTNPFL-DIPH---DPNAAVYKSGFLARKIHAD 264
            ++   P    + +  G  P  + +  ST +     +P    +P+A     G L RK   +
Sbjct: 2173 DEANGPRGERQTRTRGPAPSAMPQSRSTESAHAATLPPRGPEPSAQEQMEGMLCRKQEME 2232

Query: 265  MDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHALASKATDY 324
              GKK     R W+  Y VL+   L   KD  K   A      +  VS+  A  S A DY
Sbjct: 2233 AFGKKA--ANRSWQNVYCVLRRGSLGFYKDA-KAASAGVPYHGEVPVSLARAQGSVAFDY 2289

Query: 325  EKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPL 384
             K+ +VFKL   D +  LFQ +   EM  W+  +N   A  S     +A G  ++   P+
Sbjct: 2290 RKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATAS-----SASGEPEE---PV 2341

Query: 385  LPATTTKLSQ 394
            +P+TT  +++
Sbjct: 2342 VPSTTRGMTR 2351


>gi|67782321 spectrin beta isoform a [Homo sapiens]
          Length = 2328

 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 34/119 (28%), Positives = 56/119 (47%), Gaps = 3/119 (2%)

Query: 241  LDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEK 300
            L  P D   +V   G+L RK   D++G       R W   Y VL+ + L   KD      
Sbjct: 2169 LPAPRDHGQSVQMEGYLGRK--HDLEGPNKKASNRSWNNLYCVLRNSELTFYKDAKNLAL 2226

Query: 301  ALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKIN 359
             +     +  +++ HA+   A +Y+KK +VFKL+ ++    LF  +  EEM  W+  ++
Sbjct: 2227 GMPYHG-EEPLALRHAICEIAANYKKKKHVFKLRLSNGSEWLFHGKDEEEMLSWLQGVS 2284


>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
            sapiens]
          Length = 2364

 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 61/237 (25%), Positives = 97/237 (40%), Gaps = 34/237 (14%)

Query: 198  NEKLEWAVDDEEKKKSPSESTEEKANGTHP-KTISRIGSTTNPFLDIPHDPNAAVYKSGF 256
            N   E     +E    PS +++ KA    P ++ + + + T         P+A +   GF
Sbjct: 2152 NGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQ------ETPSAQM--EGF 2203

Query: 257  LARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHA 316
            L RK   +   KK     R W   Y V+    +   KD       +     +  VS+  A
Sbjct: 2204 LNRKHEWEAHNKKA--SSRSWHNVYCVINNQEMGFYKDAKTAASGIPYHS-EVPVSLKEA 2260

Query: 317  LASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGS 376
            +   A DY+KK +VFKL+  D    LFQ +  EEM  WI  I+            +AI S
Sbjct: 2261 VCEVALDYKKKKHVFKLRLNDGNEYLFQAKDDEEMNTWIQAIS------------SAISS 2308

Query: 377  QKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDEYK 433
             K      + A+T       + ++  + +  IT+E +      P K+ K K+ D+ K
Sbjct: 2309 DKH----EVSASTQSTPASSRAQTLPTSVVTITSESS------PGKREKDKEKDKEK 2355


>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
          Length = 1397

 Score = 56.2 bits (134), Expect = 7e-08
 Identities = 37/115 (32%), Positives = 53/115 (46%), Gaps = 7/115 (6%)

Query: 251 VYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSE------ 304
           + + G+L  K      GKK   G R WK  YA L+   L L K+  +P  A +       
Sbjct: 595 IRREGWLYYKQILTKKGKKAGSGLRQWKRVYAALRARSLSLSKERREPGPAAAGAAAAGA 654

Query: 305 -EDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKI 358
            ED    V +   L   +    K+ +VF+L TAD+   LFQ +  ++M GWI  I
Sbjct: 655 GEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAI 709


>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
          Length = 1958

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 37/106 (34%), Positives = 54/106 (50%), Gaps = 4/106 (3%)

Query: 253  KSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAVS 312
            K G+L  +      GK+     R WK  Y VL+G  LYL KD+ + +   SEE+    +S
Sbjct: 934  KEGWLHFRPLVTDKGKRVGGSIRPWKQMYVVLRGHSLYLYKDK-REQTTPSEEE--QPIS 990

Query: 313  VHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKI 358
            V+  L   +    K+ NVF+L T+D    LFQ +  ++M  WI  I
Sbjct: 991  VNACLIDISYSETKRKNVFRLTTSDCE-CLFQAEDRDDMLAWIKTI 1035


>gi|48928044 F-box only protein 8 [Homo sapiens]
          Length = 319

 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 36/119 (30%), Positives = 63/119 (52%), Gaps = 7/119 (5%)

Query: 83  VAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQER-ERVLIHFSNRYFYCNPDTIA--- 138
           V ++ +   +F    L  +LR FF+      E  E  E ++  FS+R+  CNPD +    
Sbjct: 195 VLDDLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRELG 254

Query: 139 -SQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSI 196
            S D V+ L  +++LL+ DL   ++  KM+ +EFI N +   + +  S+D +  LY++I
Sbjct: 255 LSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTRRAAQNI--SEDFVGHLYDNI 311


>gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo
           sapiens]
          Length = 1591

 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 70/302 (23%), Positives = 129/302 (42%), Gaps = 43/302 (14%)

Query: 167 TCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTH 226
           T + F+ +  G +   D ++   + +Y + + E      + E  +++ S  ++E+++GT 
Sbjct: 361 TGRAFVGSDSGSSSTGDAAR---QGVYENFRRELEMSTTNSESLEEAGSAHSDEQSSGT- 416

Query: 227 PKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARK---IHADMDGKKTPRGKRGWKTFYAV 283
              +S  G +      +       V K+G LA K   +H   + K     +R WK ++  
Sbjct: 417 ---LSSPGQSDI----LLTAAQGTVRKAGALAVKNFLVHKK-NKKVESATRRKWKHYWVS 468

Query: 284 LKGTVLYLQKDEYKPEKALSEEDL-KNAVSVHHALASKATDYEKKPNVFKLKTADWRVLL 342
           LKG  L+  + + +    +    + K+AV V +++     ++ KK  VF L  +     L
Sbjct: 469 LKGCTLFFYESDGR--SGIDHNSIPKHAVWVENSIVQAVPEHPKKDFVFCLSNSLGDAFL 526

Query: 343 FQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQ-----EEQ 397
           FQT S  E++ WI       A+ SA     A    K+ +  LL +   KL Q     E+ 
Sbjct: 527 FQTTSQTELENWI------TAIHSACATAVARHHHKEDTLRLLKSEIKKLEQKIDMDEKM 580

Query: 398 LKSHESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLE---FEKTRYEMYVSILK 454
            K  E +L  +T           D K K   +D+  + +  LE    +  R+  Y++ L+
Sbjct: 581 KKMGEMQLSSVT-----------DSKKKKTILDQIFVWEQNLEQFQMDLFRFRCYLASLQ 629

Query: 455 EG 456
            G
Sbjct: 630 GG 631


>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a
           [Homo sapiens]
          Length = 1701

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 49/208 (23%), Positives = 85/208 (40%), Gaps = 12/208 (5%)

Query: 251 VYKSGFLARK--IHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLK 308
           V K+G+L  K  +    + K     +R WK ++  LKG  L L  + Y           +
Sbjct: 507 VRKAGWLFFKPLVTVQKERKLELVARRKWKQYWVTLKGCTL-LFYETYGKNSMDQSSAPR 565

Query: 309 NAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAP 368
            A+    ++     ++ KK NVF L  +   V LFQ  S  +++ W      V AV SA 
Sbjct: 566 CALFAEDSIVQSVPEHPKKENVFCLSNSFGDVYLFQATSQTDLENW------VTAVHSAC 619

Query: 369 PFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKAKD 428
               A    K+ +  LL   T  L Q+  + S   K+ ++   +    S P ++K     
Sbjct: 620 ASLFAKKHGKEDTLRLLKNQTKNLLQKIDMDSKMKKMAELQLSVV---SDPKNRKAIENQ 676

Query: 429 VDEYKLKDHYLEFEKTRYEMYVSILKEG 456
           + +++        +  R   Y++ L+ G
Sbjct: 677 IQQWEQNLEKFHMDLFRMRCYLASLQGG 704


>gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo
           sapiens]
          Length = 1048

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 48/190 (25%), Positives = 75/190 (39%), Gaps = 19/190 (10%)

Query: 214 PSESTEEKANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRG 273
           P E    +A  T  K ++  G  ++    +  +PNA V K+G+L          K+   G
Sbjct: 27  PPERPSVRATRTARKAVA-FGKRSH---SMKRNPNAPVTKAGWLF---------KQASSG 73

Query: 274 KRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKL 333
            + W   + VL    L+  KDE K E  L    L +        A + +D   + + FK 
Sbjct: 74  VKQWNKRWFVLVDRCLFYYKDE-KEESILGSIPLLS----FRVAAVQPSDNISRKHTFKA 128

Query: 334 KTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLS 393
           + A  R   F  +SPEE + WI  +   A V   PP   ++    + S     +     S
Sbjct: 129 EHAGVRTYFFSAESPEEQEAWIQAMGEAARV-QIPPAQKSVPQAVRHSHEKPDSENVPPS 187

Query: 394 QEEQLKSHES 403
           +  Q   H S
Sbjct: 188 KHHQQPPHNS 197


>gi|20149626 pleckstrin homology domain containing, family O member
           1 [Homo sapiens]
          Length = 409

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 34/94 (36%), Positives = 45/94 (47%), Gaps = 17/94 (18%)

Query: 277 WKTFYAVLKGTVLYLQKDEYKPEKALSE----------EDLKNAVSVHHALASKAT-DYE 325
           WK  Y VLKG  LY+ + E K EK + E          E+L+ + S      SK T  + 
Sbjct: 41  WKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLAHS 100

Query: 326 KKPNVFKLKTADWRVLLFQTQSPEEMQGWINKIN 359
           K+P      TA    L+F   SPEE + WIN +N
Sbjct: 101 KQPG----NTAP--NLIFLAVSPEEKESWINALN 128


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.129    0.373 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,055,559
Number of Sequences: 37866
Number of extensions: 918477
Number of successful extensions: 2947
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 44
Number of HSP's successfully gapped in prelim test: 69
Number of HSP's that attempted gapping in prelim test: 2810
Number of HSP's gapped (non-prelim): 172
length of query: 513
length of database: 18,247,518
effective HSP length: 107
effective length of query: 406
effective length of database: 14,195,856
effective search space: 5763517536
effective search space used: 5763517536
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.