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Search of human proteins with 45594312
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45594312 TNF receptor-associated factor 7 [Homo sapiens]
(670 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45594312 TNF receptor-associated factor 7 [Homo sapiens] 1381 0.0
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 134 2e-31
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 134 2e-31
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 134 2e-31
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 130 5e-30
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 130 5e-30
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 130 5e-30
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 126 7e-29
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 126 7e-29
gi|157266266 WD repeat domain 86 [Homo sapiens] 115 1e-25
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 114 4e-25
gi|16554629 WD repeat domain 5 [Homo sapiens] 97 4e-20
gi|16554627 WD repeat domain 5 [Homo sapiens] 97 4e-20
gi|23199987 WD repeat domain 5B [Homo sapiens] 97 6e-20
gi|32189425 WD repeat domain 69 [Homo sapiens] 92 2e-18
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 89 1e-17
gi|11968023 zinc finger protein 106 homolog [Homo sapiens] 88 3e-17
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 84 3e-16
gi|38569484 kinesin family member 21A [Homo sapiens] 84 4e-16
gi|113865883 WD repeat domain 38 [Homo sapiens] 79 1e-14
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 77 4e-14
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 77 4e-14
gi|13376840 WD repeat domain 61 [Homo sapiens] 76 1e-13
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 74 3e-13
gi|19913367 transducin beta-like 1Y [Homo sapiens] 72 2e-12
gi|19913365 transducin beta-like 1Y [Homo sapiens] 72 2e-12
gi|15150805 transducin beta-like 1Y [Homo sapiens] 72 2e-12
gi|19913369 transducin beta-like 3 [Homo sapiens] 70 5e-12
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 70 6e-12
gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens] 70 6e-12
>gi|45594312 TNF receptor-associated factor 7 [Homo sapiens]
Length = 670
Score = 1381 bits (3575), Expect = 0.0
Identities = 670/670 (100%), Positives = 670/670 (100%)
Query: 1 MSSGKSARYNRFSGGPSNLPTPDVTTGTRMETTFGPAFSAVTTITKADGTSTYKQHCRTP 60
MSSGKSARYNRFSGGPSNLPTPDVTTGTRMETTFGPAFSAVTTITKADGTSTYKQHCRTP
Sbjct: 1 MSSGKSARYNRFSGGPSNLPTPDVTTGTRMETTFGPAFSAVTTITKADGTSTYKQHCRTP 60
Query: 61 SSSSTLAYSPRDEEDSMPPISTPRRSDSAISVRSLHSESSMSLRSTFSLPEEEEEPEPLV 120
SSSSTLAYSPRDEEDSMPPISTPRRSDSAISVRSLHSESSMSLRSTFSLPEEEEEPEPLV
Sbjct: 61 SSSSTLAYSPRDEEDSMPPISTPRRSDSAISVRSLHSESSMSLRSTFSLPEEEEEPEPLV 120
Query: 121 FAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRCALKSEKCPVDNVKLTVVVNNIAVAEQ 180
FAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRCALKSEKCPVDNVKLTVVVNNIAVAEQ
Sbjct: 121 FAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRCALKSEKCPVDNVKLTVVVNNIAVAEQ 180
Query: 181 IGELFIHCRHGCRVAGSGKPPIFEVDPRGCPFTIKLSARKDHEGSCDYRPVRCPNNPSCP 240
IGELFIHCRHGCRVAGSGKPPIFEVDPRGCPFTIKLSARKDHEGSCDYRPVRCPNNPSCP
Sbjct: 181 IGELFIHCRHGCRVAGSGKPPIFEVDPRGCPFTIKLSARKDHEGSCDYRPVRCPNNPSCP 240
Query: 241 PLLRMNLEAHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHE 300
PLLRMNLEAHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHE
Sbjct: 241 PLLRMNLEAHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHE 300
Query: 301 MHVALAQKDQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASM 360
MHVALAQKDQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASM
Sbjct: 301 MHVALAQKDQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASM 360
Query: 361 LNDELSHINARLNMGILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTI 420
LNDELSHINARLNMGILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTI
Sbjct: 361 LNDELSHINARLNMGILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTI 420
Query: 421 KVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDN 480
KVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDN
Sbjct: 421 KVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDN 480
Query: 481 PVCTLVSSHNVLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALVAAQSYLYSGSYQT 540
PVCTLVSSHNVLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALVAAQSYLYSGSYQT
Sbjct: 481 PVCTLVSSHNVLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALVAAQSYLYSGSYQT 540
Query: 541 IKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVG 600
IKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVG
Sbjct: 541 IKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVG 600
Query: 601 TVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGA 660
TVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGA
Sbjct: 601 TVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGA 660
Query: 661 VDSTVKVWTC 670
VDSTVKVWTC
Sbjct: 661 VDSTVKVWTC 670
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 134 bits (338), Expect = 2e-31
Identities = 90/281 (32%), Positives = 143/281 (50%), Gaps = 15/281 (5%)
Query: 394 GHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLY 453
GH V C+ G+ + SGS D T+KVW + T KC +TL GH G V + ++ +
Sbjct: 260 GHDDHV-ITCLQFCGNRIVSGSDDNTLKVW-SAVTGKCLRTLVGHTGGVWSSQMRDNIII 317
Query: 454 SGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKA-IKVWDI-VGTELK 511
SGS D T+ VW+ + + ++T+ H + V + + SGS A ++VWDI G L
Sbjct: 318 SGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLH 377
Query: 512 LKKELTGLNHWVRALVAAQSYLYSGSYQ-TIKIWDIRTLDCIHVLQTSGGSVYSIAVTNH 570
+ L G VR + + SG+Y +K+WD T C+H LQ VYS+
Sbjct: 378 V---LMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGI 434
Query: 571 HIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSM 630
H+V G+ + I VWD+E+ + TLTGH + + + S + D ++++W +
Sbjct: 435 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL----KDNILVSGNADSTVKIWDI 490
Query: 631 DNMICTQTLL---RHQGSVTALAVSRGRLFSGAVDSTVKVW 668
C QTL +HQ +VT L ++ + + + D TVK+W
Sbjct: 491 KTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLW 531
Score = 108 bits (269), Expect = 2e-23
Identities = 76/249 (30%), Positives = 126/249 (50%), Gaps = 14/249 (5%)
Query: 387 KCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALC 446
KC T VGH G VW +++ SGS+D+T+KVW+ T +C TL GH V +
Sbjct: 294 KCLRTLVGHTGGVW--SSQMRDNIIISGSTDRTLKVWN-AETGECIHTLYGHTSTVRCMH 350
Query: 447 IQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPV-CTLVSSHNVLFSGSLKAIKVWDI 505
+ ++ SGS D T+ VWDI+ Q ++ + H V C V+ +KVWD
Sbjct: 351 LHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWD- 409
Query: 506 VGTELKLKKELTGLNHWVRALVAAQSYLYSGSYQT-IKIWDIRTLDCIHVLQTSGGSVYS 564
TE L L G + V +L ++ SGS T I++WD+ T +CIH L
Sbjct: 410 PETETCL-HTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 468
Query: 565 IAVTNHHIVCGTYENLIHVWDIESKEQVRTLTG---HVGTVYALAVISTPDQTKVFSASY 621
+ + ++ +V G ++ + +WDI++ + ++TL G H V L ++ V ++S
Sbjct: 469 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQF----NKNFVITSSD 524
Query: 622 DRSLRVWSM 630
D ++++W +
Sbjct: 525 DGTVKLWDL 533
Score = 89.7 bits (221), Expect = 8e-18
Identities = 68/217 (31%), Positives = 103/217 (47%), Gaps = 21/217 (9%)
Query: 387 KCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALC 446
+C +GH V CV G + SG+ D +KVWD T C TL+GH V +L
Sbjct: 374 QCLHVLMGHVAAV--RCVQYDGRRVVSGAYDFMVKVWDP-ETETCLHTLQGHTNRVYSLQ 430
Query: 447 IQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKA-IKVWDI 505
G + SGS D +I VWD++ ++T+ H + + N+L SG+ + +K+WDI
Sbjct: 431 FDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDI 490
Query: 506 VGTELKLKKELTGLNHWVRALVAAQS----YLYSGSYQTIKIWDIRTLDCIHVLQT---- 557
+ + L G N A+ Q + S T+K+WD++T + I L T
Sbjct: 491 KTGQCL--QTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESG 548
Query: 558 -SGGSVYSIAVTNHHIVC------GTYENLIHVWDIE 587
SGG V+ I +N +VC GT E + V D +
Sbjct: 549 GSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFD 585
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 134 bits (338), Expect = 2e-31
Identities = 90/281 (32%), Positives = 143/281 (50%), Gaps = 15/281 (5%)
Query: 394 GHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLY 453
GH V C+ G+ + SGS D T+KVW + T KC +TL GH G V + ++ +
Sbjct: 378 GHDDHV-ITCLQFCGNRIVSGSDDNTLKVW-SAVTGKCLRTLVGHTGGVWSSQMRDNIII 435
Query: 454 SGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKA-IKVWDI-VGTELK 511
SGS D T+ VW+ + + ++T+ H + V + + SGS A ++VWDI G L
Sbjct: 436 SGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLH 495
Query: 512 LKKELTGLNHWVRALVAAQSYLYSGSYQ-TIKIWDIRTLDCIHVLQTSGGSVYSIAVTNH 570
+ L G VR + + SG+Y +K+WD T C+H LQ VYS+
Sbjct: 496 V---LMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGI 552
Query: 571 HIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSM 630
H+V G+ + I VWD+E+ + TLTGH + + + S + D ++++W +
Sbjct: 553 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL----KDNILVSGNADSTVKIWDI 608
Query: 631 DNMICTQTLL---RHQGSVTALAVSRGRLFSGAVDSTVKVW 668
C QTL +HQ +VT L ++ + + + D TVK+W
Sbjct: 609 KTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLW 649
Score = 108 bits (269), Expect = 2e-23
Identities = 76/249 (30%), Positives = 126/249 (50%), Gaps = 14/249 (5%)
Query: 387 KCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALC 446
KC T VGH G VW +++ SGS+D+T+KVW+ T +C TL GH V +
Sbjct: 412 KCLRTLVGHTGGVW--SSQMRDNIIISGSTDRTLKVWN-AETGECIHTLYGHTSTVRCMH 468
Query: 447 IQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPV-CTLVSSHNVLFSGSLKAIKVWDI 505
+ ++ SGS D T+ VWDI+ Q ++ + H V C V+ +KVWD
Sbjct: 469 LHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWD- 527
Query: 506 VGTELKLKKELTGLNHWVRALVAAQSYLYSGSYQT-IKIWDIRTLDCIHVLQTSGGSVYS 564
TE L L G + V +L ++ SGS T I++WD+ T +CIH L
Sbjct: 528 PETETCL-HTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 586
Query: 565 IAVTNHHIVCGTYENLIHVWDIESKEQVRTLTG---HVGTVYALAVISTPDQTKVFSASY 621
+ + ++ +V G ++ + +WDI++ + ++TL G H V L ++ V ++S
Sbjct: 587 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQF----NKNFVITSSD 642
Query: 622 DRSLRVWSM 630
D ++++W +
Sbjct: 643 DGTVKLWDL 651
Score = 89.7 bits (221), Expect = 8e-18
Identities = 68/217 (31%), Positives = 103/217 (47%), Gaps = 21/217 (9%)
Query: 387 KCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALC 446
+C +GH V CV G + SG+ D +KVWD T C TL+GH V +L
Sbjct: 492 QCLHVLMGHVAAV--RCVQYDGRRVVSGAYDFMVKVWDP-ETETCLHTLQGHTNRVYSLQ 548
Query: 447 IQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKA-IKVWDI 505
G + SGS D +I VWD++ ++T+ H + + N+L SG+ + +K+WDI
Sbjct: 549 FDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDI 608
Query: 506 VGTELKLKKELTGLNHWVRALVAAQS----YLYSGSYQTIKIWDIRTLDCIHVLQT---- 557
+ + L G N A+ Q + S T+K+WD++T + I L T
Sbjct: 609 KTGQCL--QTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESG 666
Query: 558 -SGGSVYSIAVTNHHIVC------GTYENLIHVWDIE 587
SGG V+ I +N +VC GT E + V D +
Sbjct: 667 GSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFD 703
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 134 bits (338), Expect = 2e-31
Identities = 90/281 (32%), Positives = 143/281 (50%), Gaps = 15/281 (5%)
Query: 394 GHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLY 453
GH V C+ G+ + SGS D T+KVW + T KC +TL GH G V + ++ +
Sbjct: 298 GHDDHV-ITCLQFCGNRIVSGSDDNTLKVW-SAVTGKCLRTLVGHTGGVWSSQMRDNIII 355
Query: 454 SGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKA-IKVWDI-VGTELK 511
SGS D T+ VW+ + + ++T+ H + V + + SGS A ++VWDI G L
Sbjct: 356 SGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLH 415
Query: 512 LKKELTGLNHWVRALVAAQSYLYSGSYQ-TIKIWDIRTLDCIHVLQTSGGSVYSIAVTNH 570
+ L G VR + + SG+Y +K+WD T C+H LQ VYS+
Sbjct: 416 V---LMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGI 472
Query: 571 HIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSM 630
H+V G+ + I VWD+E+ + TLTGH + + + S + D ++++W +
Sbjct: 473 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL----KDNILVSGNADSTVKIWDI 528
Query: 631 DNMICTQTLL---RHQGSVTALAVSRGRLFSGAVDSTVKVW 668
C QTL +HQ +VT L ++ + + + D TVK+W
Sbjct: 529 KTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLW 569
Score = 108 bits (269), Expect = 2e-23
Identities = 76/249 (30%), Positives = 126/249 (50%), Gaps = 14/249 (5%)
Query: 387 KCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALC 446
KC T VGH G VW +++ SGS+D+T+KVW+ T +C TL GH V +
Sbjct: 332 KCLRTLVGHTGGVW--SSQMRDNIIISGSTDRTLKVWN-AETGECIHTLYGHTSTVRCMH 388
Query: 447 IQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPV-CTLVSSHNVLFSGSLKAIKVWDI 505
+ ++ SGS D T+ VWDI+ Q ++ + H V C V+ +KVWD
Sbjct: 389 LHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWD- 447
Query: 506 VGTELKLKKELTGLNHWVRALVAAQSYLYSGSYQT-IKIWDIRTLDCIHVLQTSGGSVYS 564
TE L L G + V +L ++ SGS T I++WD+ T +CIH L
Sbjct: 448 PETETCL-HTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 506
Query: 565 IAVTNHHIVCGTYENLIHVWDIESKEQVRTLTG---HVGTVYALAVISTPDQTKVFSASY 621
+ + ++ +V G ++ + +WDI++ + ++TL G H V L ++ V ++S
Sbjct: 507 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQF----NKNFVITSSD 562
Query: 622 DRSLRVWSM 630
D ++++W +
Sbjct: 563 DGTVKLWDL 571
Score = 89.7 bits (221), Expect = 8e-18
Identities = 68/217 (31%), Positives = 103/217 (47%), Gaps = 21/217 (9%)
Query: 387 KCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALC 446
+C +GH V CV G + SG+ D +KVWD T C TL+GH V +L
Sbjct: 412 QCLHVLMGHVAAV--RCVQYDGRRVVSGAYDFMVKVWDP-ETETCLHTLQGHTNRVYSLQ 468
Query: 447 IQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKA-IKVWDI 505
G + SGS D +I VWD++ ++T+ H + + N+L SG+ + +K+WDI
Sbjct: 469 FDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDI 528
Query: 506 VGTELKLKKELTGLNHWVRALVAAQS----YLYSGSYQTIKIWDIRTLDCIHVLQT---- 557
+ + L G N A+ Q + S T+K+WD++T + I L T
Sbjct: 529 KTGQCL--QTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESG 586
Query: 558 -SGGSVYSIAVTNHHIVC------GTYENLIHVWDIE 587
SGG V+ I +N +VC GT E + V D +
Sbjct: 587 GSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFD 623
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 130 bits (326), Expect = 5e-30
Identities = 80/278 (28%), Positives = 137/278 (49%), Gaps = 17/278 (6%)
Query: 403 CVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTII 462
C+ + + SG D +IK+WD T+ +C K L GH G VL L + +GS+D T+
Sbjct: 245 CLQYDDEKIISGLRDNSIKIWDK-TSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVR 303
Query: 463 VWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSL-KAIKVWDIV-GTELKLKKELTGLN 520
VWD+ + +NT+ H+ V L S+ ++ + S ++I VWD+ T++ L++ L G
Sbjct: 304 VWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHR 363
Query: 521 HWVRALVAAQSYLYSGS-YQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYEN 579
V + Y+ S S +TIK+W T + + L + + + +V G+ +N
Sbjct: 364 AAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDN 423
Query: 580 LIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMD-------- 631
I +WDIE +R L GH V + D ++ S +YD ++VW +
Sbjct: 424 TIRLWDIECGACLRVLEGHEELVRCIRF----DNKRIVSGAYDGKIKVWDLQAALDPRAP 479
Query: 632 -NMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVW 668
+ +C +TL+ H G V L ++ S + D T+ +W
Sbjct: 480 ASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIW 517
Score = 66.6 bits (161), Expect = 7e-11
Identities = 40/133 (30%), Positives = 66/133 (49%), Gaps = 7/133 (5%)
Query: 540 TIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHV 599
+IKIWD +L+C+ VL GSV + IV G+ ++ + VWD+ + E + TL H
Sbjct: 261 SIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHN 320
Query: 600 GTVYALAVISTPDQTKVFSASYDRSLRVWSM---DNMICTQTLLRHQGSVTALAVSRGRL 656
V L + + S DRS+ VW M ++ + L+ H+ +V + +
Sbjct: 321 EAVLHLRF----SNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYI 376
Query: 657 FSGAVDSTVKVWT 669
S + D T+KVW+
Sbjct: 377 VSASGDRTIKVWS 389
Score = 62.8 bits (151), Expect = 1e-09
Identities = 33/107 (30%), Positives = 55/107 (51%), Gaps = 4/107 (3%)
Query: 562 VYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASY 621
VY + + I+ G +N I +WD S E ++ LTGH G+V L D+ + + S
Sbjct: 243 VYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY----DERVIVTGSS 298
Query: 622 DRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVW 668
D ++RVW ++ TL+ H +V L S G + + + D ++ VW
Sbjct: 299 DSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVW 345
Score = 41.2 bits (95), Expect = 0.003
Identities = 28/90 (31%), Positives = 38/90 (42%), Gaps = 10/90 (11%)
Query: 388 CKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYK--------CQKTLEGHD 439
C GH+ V C+ + SG+ D IKVWD C +TL H
Sbjct: 435 CLRVLEGHEELV--RCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHS 492
Query: 440 GIVLALCIQGCKLYSGSADCTIIVWDIQNL 469
G V L ++ S S D TI++WD N+
Sbjct: 493 GRVFRLQFDEFQIISSSHDDTILIWDFLNV 522
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 130 bits (326), Expect = 5e-30
Identities = 80/278 (28%), Positives = 137/278 (49%), Gaps = 17/278 (6%)
Query: 403 CVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTII 462
C+ + + SG D +IK+WD T+ +C K L GH G VL L + +GS+D T+
Sbjct: 211 CLQYDDEKIISGLRDNSIKIWDK-TSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVR 269
Query: 463 VWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSL-KAIKVWDIV-GTELKLKKELTGLN 520
VWD+ + +NT+ H+ V L S+ ++ + S ++I VWD+ T++ L++ L G
Sbjct: 270 VWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHR 329
Query: 521 HWVRALVAAQSYLYSGS-YQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYEN 579
V + Y+ S S +TIK+W T + + L + + + +V G+ +N
Sbjct: 330 AAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDN 389
Query: 580 LIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMD-------- 631
I +WDIE +R L GH V + D ++ S +YD ++VW +
Sbjct: 390 TIRLWDIECGACLRVLEGHEELVRCIRF----DNKRIVSGAYDGKIKVWDLQAALDPRAP 445
Query: 632 -NMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVW 668
+ +C +TL+ H G V L ++ S + D T+ +W
Sbjct: 446 ASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIW 483
Score = 66.6 bits (161), Expect = 7e-11
Identities = 40/133 (30%), Positives = 66/133 (49%), Gaps = 7/133 (5%)
Query: 540 TIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHV 599
+IKIWD +L+C+ VL GSV + IV G+ ++ + VWD+ + E + TL H
Sbjct: 227 SIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHN 286
Query: 600 GTVYALAVISTPDQTKVFSASYDRSLRVWSM---DNMICTQTLLRHQGSVTALAVSRGRL 656
V L + + S DRS+ VW M ++ + L+ H+ +V + +
Sbjct: 287 EAVLHLRF----SNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYI 342
Query: 657 FSGAVDSTVKVWT 669
S + D T+KVW+
Sbjct: 343 VSASGDRTIKVWS 355
Score = 62.8 bits (151), Expect = 1e-09
Identities = 33/107 (30%), Positives = 55/107 (51%), Gaps = 4/107 (3%)
Query: 562 VYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASY 621
VY + + I+ G +N I +WD S E ++ LTGH G+V L D+ + + S
Sbjct: 209 VYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY----DERVIVTGSS 264
Query: 622 DRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVW 668
D ++RVW ++ TL+ H +V L S G + + + D ++ VW
Sbjct: 265 DSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVW 311
Score = 41.2 bits (95), Expect = 0.003
Identities = 28/90 (31%), Positives = 38/90 (42%), Gaps = 10/90 (11%)
Query: 388 CKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYK--------CQKTLEGHD 439
C GH+ V C+ + SG+ D IKVWD C +TL H
Sbjct: 401 CLRVLEGHEELV--RCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHS 458
Query: 440 GIVLALCIQGCKLYSGSADCTIIVWDIQNL 469
G V L ++ S S D TI++WD N+
Sbjct: 459 GRVFRLQFDEFQIISSSHDDTILIWDFLNV 488
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 130 bits (326), Expect = 5e-30
Identities = 80/278 (28%), Positives = 137/278 (49%), Gaps = 17/278 (6%)
Query: 403 CVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTII 462
C+ + + SG D +IK+WD T+ +C K L GH G VL L + +GS+D T+
Sbjct: 232 CLQYDDEKIISGLRDNSIKIWDK-TSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVR 290
Query: 463 VWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSL-KAIKVWDIV-GTELKLKKELTGLN 520
VWD+ + +NT+ H+ V L S+ ++ + S ++I VWD+ T++ L++ L G
Sbjct: 291 VWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHR 350
Query: 521 HWVRALVAAQSYLYSGS-YQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYEN 579
V + Y+ S S +TIK+W T + + L + + + +V G+ +N
Sbjct: 351 AAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDN 410
Query: 580 LIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMD-------- 631
I +WDIE +R L GH V + D ++ S +YD ++VW +
Sbjct: 411 TIRLWDIECGACLRVLEGHEELVRCIRF----DNKRIVSGAYDGKIKVWDLQAALDPRAP 466
Query: 632 -NMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVW 668
+ +C +TL+ H G V L ++ S + D T+ +W
Sbjct: 467 ASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIW 504
Score = 66.6 bits (161), Expect = 7e-11
Identities = 40/133 (30%), Positives = 66/133 (49%), Gaps = 7/133 (5%)
Query: 540 TIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHV 599
+IKIWD +L+C+ VL GSV + IV G+ ++ + VWD+ + E + TL H
Sbjct: 248 SIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHN 307
Query: 600 GTVYALAVISTPDQTKVFSASYDRSLRVWSM---DNMICTQTLLRHQGSVTALAVSRGRL 656
V L + + S DRS+ VW M ++ + L+ H+ +V + +
Sbjct: 308 EAVLHLRF----SNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYI 363
Query: 657 FSGAVDSTVKVWT 669
S + D T+KVW+
Sbjct: 364 VSASGDRTIKVWS 376
Score = 62.8 bits (151), Expect = 1e-09
Identities = 33/107 (30%), Positives = 55/107 (51%), Gaps = 4/107 (3%)
Query: 562 VYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASY 621
VY + + I+ G +N I +WD S E ++ LTGH G+V L D+ + + S
Sbjct: 230 VYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY----DERVIVTGSS 285
Query: 622 DRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVW 668
D ++RVW ++ TL+ H +V L S G + + + D ++ VW
Sbjct: 286 DSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVW 332
Score = 41.2 bits (95), Expect = 0.003
Identities = 28/90 (31%), Positives = 38/90 (42%), Gaps = 10/90 (11%)
Query: 388 CKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYK--------CQKTLEGHD 439
C GH+ V C+ + SG+ D IKVWD C +TL H
Sbjct: 422 CLRVLEGHEELV--RCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHS 479
Query: 440 GIVLALCIQGCKLYSGSADCTIIVWDIQNL 469
G V L ++ S S D TI++WD N+
Sbjct: 480 GRVFRLQFDEFQIISSSHDDTILIWDFLNV 509
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 126 bits (316), Expect = 7e-29
Identities = 79/278 (28%), Positives = 135/278 (48%), Gaps = 17/278 (6%)
Query: 403 CVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTII 462
C+ + SG D TIK+WD T +C++ L GH G VL L + +GS+D T+
Sbjct: 272 CLQYDDQKIVSGLRDNTIKIWDK-NTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVR 330
Query: 463 VWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSL-KAIKVWDIVG-TELKLKKELTGLN 520
VWD+ + +NT+ H V L ++ ++ + S ++I VWD+ T++ L++ L G
Sbjct: 331 VWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHR 390
Query: 521 HWVRALVAAQSYLYSGS-YQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYEN 579
V + Y+ S S +TIK+W+ T + + L + + + +V G+ +N
Sbjct: 391 AAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDN 450
Query: 580 LIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSM--------- 630
I +WDIE +R L GH V + D ++ S +YD ++VW +
Sbjct: 451 TIRLWDIECGACLRVLEGHEELVRCIRF----DNKRIVSGAYDGKIKVWDLVAALDPRAP 506
Query: 631 DNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVW 668
+C +TL+ H G V L ++ S + D T+ +W
Sbjct: 507 AGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIW 544
Score = 64.3 bits (155), Expect = 3e-10
Identities = 36/121 (29%), Positives = 59/121 (48%), Gaps = 4/121 (3%)
Query: 548 TLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAV 607
+L IH + VY + + IV G +N I +WD + E R LTGH G+V L
Sbjct: 256 SLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY 315
Query: 608 ISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKV 667
D+ + + S D ++RVW ++ TL+ H +V L + G + + + D ++ V
Sbjct: 316 ----DERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAV 371
Query: 668 W 668
W
Sbjct: 372 W 372
Score = 41.6 bits (96), Expect = 0.002
Identities = 28/89 (31%), Positives = 37/89 (41%), Gaps = 10/89 (11%)
Query: 388 CKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYK--------CQKTLEGHD 439
C GH+ V C+ + SG+ D IKVWD C +TL H
Sbjct: 462 CLRVLEGHEELV--RCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHS 519
Query: 440 GIVLALCIQGCKLYSGSADCTIIVWDIQN 468
G V L ++ S S D TI++WD N
Sbjct: 520 GRVFRLQFDEFQIVSSSHDDTILIWDFLN 548
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 126 bits (316), Expect = 7e-29
Identities = 79/278 (28%), Positives = 135/278 (48%), Gaps = 17/278 (6%)
Query: 403 CVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTII 462
C+ + SG D TIK+WD T +C++ L GH G VL L + +GS+D T+
Sbjct: 308 CLQYDDQKIVSGLRDNTIKIWDK-NTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVR 366
Query: 463 VWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSL-KAIKVWDIVG-TELKLKKELTGLN 520
VWD+ + +NT+ H V L ++ ++ + S ++I VWD+ T++ L++ L G
Sbjct: 367 VWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHR 426
Query: 521 HWVRALVAAQSYLYSGS-YQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYEN 579
V + Y+ S S +TIK+W+ T + + L + + + +V G+ +N
Sbjct: 427 AAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDN 486
Query: 580 LIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSM--------- 630
I +WDIE +R L GH V + D ++ S +YD ++VW +
Sbjct: 487 TIRLWDIECGACLRVLEGHEELVRCIRF----DNKRIVSGAYDGKIKVWDLVAALDPRAP 542
Query: 631 DNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVW 668
+C +TL+ H G V L ++ S + D T+ +W
Sbjct: 543 AGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIW 580
Score = 64.3 bits (155), Expect = 3e-10
Identities = 36/121 (29%), Positives = 59/121 (48%), Gaps = 4/121 (3%)
Query: 548 TLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAV 607
+L IH + VY + + IV G +N I +WD + E R LTGH G+V L
Sbjct: 292 SLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY 351
Query: 608 ISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKV 667
D+ + + S D ++RVW ++ TL+ H +V L + G + + + D ++ V
Sbjct: 352 ----DERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAV 407
Query: 668 W 668
W
Sbjct: 408 W 408
Score = 41.6 bits (96), Expect = 0.002
Identities = 28/89 (31%), Positives = 37/89 (41%), Gaps = 10/89 (11%)
Query: 388 CKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYK--------CQKTLEGHD 439
C GH+ V C+ + SG+ D IKVWD C +TL H
Sbjct: 498 CLRVLEGHEELV--RCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHS 555
Query: 440 GIVLALCIQGCKLYSGSADCTIIVWDIQN 468
G V L ++ S S D TI++WD N
Sbjct: 556 GRVFRLQFDEFQIVSSSHDDTILIWDFLN 584
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 115 bits (289), Expect = 1e-25
Identities = 83/294 (28%), Positives = 139/294 (47%), Gaps = 27/294 (9%)
Query: 395 HQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYS 454
H+G + L + G L +GS D T ++W T +C L+GH+ V ++ ++
Sbjct: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADG-QCCALLQGHESYVTFCQLEDEAAFT 72
Query: 455 GSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSL-KAIKVWDIVGTELKLK 513
SADCTI WD+ Q + R H + V ++ ++N LFS S + +VW + + ++
Sbjct: 73 CSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSV--DKGQMS 130
Query: 514 KELTGLNHWVRAL----------------VAAQSYLYSGSYQ-TIKIWDIRTLDCIHVLQ 556
+E G + V L AA L +GS T K+W + + C L+
Sbjct: 131 REFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLR 190
Query: 557 TSGGSVYSIAV--TNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQT 614
G+V + + H G+ + I WDI S EQ+R H G+V L +++
Sbjct: 191 GHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVN----R 246
Query: 615 KVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVW 668
V+S S DR+++ W D C +T H+ +V+AL G LF+G+ D+ + +
Sbjct: 247 LVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAF 300
Score = 73.6 bits (179), Expect = 6e-13
Identities = 51/164 (31%), Positives = 77/164 (46%), Gaps = 5/164 (3%)
Query: 388 CKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCI 447
C T GH G V CL + + G F+GS+D TI+ WD + + + H G V+ L +
Sbjct: 185 CHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQL-RVFREHRGSVICLEL 243
Query: 448 QGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKA-IKVWDIV 506
+YSGSAD T+ W + V T AH V L LF+GS A + +D
Sbjct: 244 VNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQ 303
Query: 507 GTELKLKKELTGLNHWVRALVAAQSYLYSGSYQ-TIKIWDIRTL 549
E L++ G + + LY+ S+ +++WD+R L
Sbjct: 304 SGE--LRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDVRGL 345
Score = 71.6 bits (174), Expect = 2e-12
Identities = 70/265 (26%), Positives = 114/265 (43%), Gaps = 31/265 (11%)
Query: 387 KCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALC 446
+C + GH V + V + + LFS S D+T +VW + + GH VL L
Sbjct: 88 QCLQVYRGHTSIVNRILVAN--NQLFSSSYDRTARVWSV-DKGQMSREFRGHRNCVLTLA 144
Query: 447 IQ----------------GCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLV--SS 488
G L +GS D T VW + + T+R H V LV +
Sbjct: 145 YSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTP 204
Query: 489 HNVLFSGSLKA-IKVWDIV-GTELKLKKELTGLNHWVRALVAAQSYLYSGSY-QTIKIWD 545
+ F+GS A I+ WDI+ G +L++ +E G V L +YSGS +T+K W
Sbjct: 205 GHTAFTGSTDATIRAWDILSGEQLRVFREHRGS---VICLELVNRLVYSGSADRTVKCWL 261
Query: 546 IRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYAL 605
T +C+ +V ++ + G+ + +D +S E R GH + +
Sbjct: 262 ADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCI 321
Query: 606 AVISTPDQTKVFSASYDRSLRVWSM 630
V +++AS+D +LR+W +
Sbjct: 322 QV----HGQVLYTASHDGALRLWDV 342
Score = 41.6 bits (96), Expect = 0.002
Identities = 24/106 (22%), Positives = 44/106 (41%), Gaps = 4/106 (3%)
Query: 564 SIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDR 623
S++ ++ G+ + +W + L GH V + + F+ S D
Sbjct: 22 SLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL----EDEAAFTCSADC 77
Query: 624 SLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVWT 669
++R W + C Q H V + V+ +LFS + D T +VW+
Sbjct: 78 TIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWS 123
Score = 40.0 bits (92), Expect = 0.007
Identities = 23/84 (27%), Positives = 43/84 (51%), Gaps = 3/84 (3%)
Query: 387 KCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALC 446
+C TF H+ V L ++ LF+GS D + +D + + ++ GH I+ +
Sbjct: 266 ECVRTFTAHRRNVSALKYHA--GTLFTGSGDACARAFDA-QSGELRRVFRGHTFIINCIQ 322
Query: 447 IQGCKLYSGSADCTIIVWDIQNLQ 470
+ G LY+ S D + +WD++ L+
Sbjct: 323 VHGQVLYTASHDGALRLWDVRGLR 346
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 114 bits (284), Expect = 4e-25
Identities = 86/309 (27%), Positives = 141/309 (45%), Gaps = 37/309 (11%)
Query: 394 GHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQ--GCK 451
GH+ PV + + + ++ S S D TIKVWD T ++TL+GH V + G
Sbjct: 106 GHRSPVTRVIFHPVFSVMVSASEDATIKVWDY-ETGDFERTLKGHTDSVQDISFDHSGKL 164
Query: 452 LYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLV---SSHNVLFSGSLKAIKVWDIVGT 508
L S SAD TI +WD Q + + T+ HD+ V ++ + +++ + K IK+W++
Sbjct: 165 LASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEV--Q 222
Query: 509 ELKLKKELTGLNHWVRALVAAQSYLYSGSY---QTIKIWDIRTLDC-------IHVL--- 555
K TG WVR + Q S QT+++W + T +C HV+
Sbjct: 223 TGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECI 282
Query: 556 ------------QTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVY 603
+ +G ++ G+ + I +WD+ + + TL GH +
Sbjct: 283 SWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDN--W 340
Query: 604 ALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGR--LFSGAV 661
V+ + S + D++LRVW N C +TL H+ VT+L + + +G+V
Sbjct: 341 VRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSV 400
Query: 662 DSTVKVWTC 670
D TVKVW C
Sbjct: 401 DQTVKVWEC 409
Score = 73.6 bits (179), Expect = 6e-13
Identities = 71/259 (27%), Positives = 111/259 (42%), Gaps = 45/259 (17%)
Query: 384 QIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGH----- 438
Q F+C T GH V + + GD + S S DKTIK+W+ T Y C KT GH
Sbjct: 180 QGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGY-CVKTFTGHREWVR 238
Query: 439 ------DGIVLALCIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVL 492
DG ++A C S D T+ VW + + +R H++ V + +
Sbjct: 239 MVRPNQDGTLIASC---------SNDQTVRVWVVATKECKAELREHEHVVECISWAPESS 289
Query: 493 FSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALVAAQSYLYSGSY-QTIKIWDIRTLDC 551
+S + + G+E K K G +L SGS +TIK+WD+ T C
Sbjct: 290 YS------SISEATGSETK-KSGKPG------------PFLLSGSRDKTIKMWDVSTGMC 330
Query: 552 IHVLQTSGGSVYSIAVTN--HHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVIS 609
+ L V + + I+ + + VWD ++K ++TL H V +L
Sbjct: 331 LMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHK 390
Query: 610 TPDQTKVFSASYDRSLRVW 628
T V + S D++++VW
Sbjct: 391 TAPY--VVTGSVDQTVKVW 407
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 97.4 bits (241), Expect = 4e-20
Identities = 75/269 (27%), Positives = 132/269 (49%), Gaps = 19/269 (7%)
Query: 376 ILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTL 435
I G+YD K + T GH+ + + S +LL S S DKT+K+WD ++ KC KTL
Sbjct: 71 IWGAYDG----KFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV-SSGKCLKTL 125
Query: 436 EGHDGIVLALCI--QGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHN--V 491
+GH V Q + SGS D ++ +WD++ + + T+ AH +PV + + + +
Sbjct: 126 KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL 185
Query: 492 LFSGSLKAI-KVWDIVGTELKLKKELTGLN---HWVRALVAAQSYLYSGSYQTIKIWDIR 547
+ S S + ++WD + LK + N +V+ + L + T+K+WD
Sbjct: 186 IVSSSYDGLCRIWDTASGQC-LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS 244
Query: 548 TLDCIHVLQTSGGSVYSI----AVTNHH-IVCGTYENLIHVWDIESKEQVRTLTGHVGTV 602
C+ Y I +VT IV G+ +NL+++W++++KE V+ L GH V
Sbjct: 245 KGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 304
Query: 603 YALAVISTPDQTKVFSASYDRSLRVWSMD 631
+ A T + + D+++++W D
Sbjct: 305 ISTACHPTENIIASAALENDKTIKLWKSD 333
Score = 93.6 bits (231), Expect = 5e-19
Identities = 83/299 (27%), Positives = 135/299 (45%), Gaps = 19/299 (6%)
Query: 386 FKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHD-GIV-L 443
+ K T GH V + G+ L S S+DK IK+W K +KT+ GH GI +
Sbjct: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG-KFEKTISGHKLGISDV 93
Query: 444 ALCIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPV--CTLVSSHNVLFSGSL-KAI 500
A L S S D T+ +WD+ + + + T++ H N V C N++ SGS +++
Sbjct: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153
Query: 501 KVWDIVGTELKLKKELTGLNHWVRALVAAQ--SYLYSGSYQTI-KIWDIRTLDCIHVLQT 557
++WD+ K K L + V A+ + S + S SY + +IWD + C+ L
Sbjct: 154 RIWDV--KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211
Query: 558 SGG---SVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYAL-AVISTPDQ 613
S + +I+ T +N + +WD + ++T TGH Y + A S
Sbjct: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG 271
Query: 614 TKVFSASYDRSLRVWSMDNMICTQTLLRHQGSV--TALAVSRGRLFSGAV--DSTVKVW 668
+ S S D + +W++ Q L H V TA + + S A+ D T+K+W
Sbjct: 272 KWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 97.4 bits (241), Expect = 4e-20
Identities = 75/269 (27%), Positives = 132/269 (49%), Gaps = 19/269 (7%)
Query: 376 ILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTL 435
I G+YD K + T GH+ + + S +LL S S DKT+K+WD ++ KC KTL
Sbjct: 71 IWGAYDG----KFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV-SSGKCLKTL 125
Query: 436 EGHDGIVLALCI--QGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHN--V 491
+GH V Q + SGS D ++ +WD++ + + T+ AH +PV + + + +
Sbjct: 126 KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL 185
Query: 492 LFSGSLKAI-KVWDIVGTELKLKKELTGLN---HWVRALVAAQSYLYSGSYQTIKIWDIR 547
+ S S + ++WD + LK + N +V+ + L + T+K+WD
Sbjct: 186 IVSSSYDGLCRIWDTASGQC-LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS 244
Query: 548 TLDCIHVLQTSGGSVYSI----AVTNHH-IVCGTYENLIHVWDIESKEQVRTLTGHVGTV 602
C+ Y I +VT IV G+ +NL+++W++++KE V+ L GH V
Sbjct: 245 KGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 304
Query: 603 YALAVISTPDQTKVFSASYDRSLRVWSMD 631
+ A T + + D+++++W D
Sbjct: 305 ISTACHPTENIIASAALENDKTIKLWKSD 333
Score = 93.6 bits (231), Expect = 5e-19
Identities = 83/299 (27%), Positives = 135/299 (45%), Gaps = 19/299 (6%)
Query: 386 FKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHD-GIV-L 443
+ K T GH V + G+ L S S+DK IK+W K +KT+ GH GI +
Sbjct: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG-KFEKTISGHKLGISDV 93
Query: 444 ALCIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPV--CTLVSSHNVLFSGSL-KAI 500
A L S S D T+ +WD+ + + + T++ H N V C N++ SGS +++
Sbjct: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153
Query: 501 KVWDIVGTELKLKKELTGLNHWVRALVAAQ--SYLYSGSYQTI-KIWDIRTLDCIHVLQT 557
++WD+ K K L + V A+ + S + S SY + +IWD + C+ L
Sbjct: 154 RIWDV--KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211
Query: 558 SGG---SVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYAL-AVISTPDQ 613
S + +I+ T +N + +WD + ++T TGH Y + A S
Sbjct: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG 271
Query: 614 TKVFSASYDRSLRVWSMDNMICTQTLLRHQGSV--TALAVSRGRLFSGAV--DSTVKVW 668
+ S S D + +W++ Q L H V TA + + S A+ D T+K+W
Sbjct: 272 KWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 96.7 bits (239), Expect = 6e-20
Identities = 83/304 (27%), Positives = 139/304 (45%), Gaps = 21/304 (6%)
Query: 381 DPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDG 440
+P KC T VGH V + G+ L S S+D+ I +W K +KTL GH+
Sbjct: 28 NPNYALKC--TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDG-KYEKTLYGHNL 84
Query: 441 IV--LALCIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPV--CTLVSSHNVLFSGS 496
+ +A +L S S D T+ +WD+++ + + T++ H N V C N++ SGS
Sbjct: 85 EISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGS 144
Query: 497 L-KAIKVWDIVGTELKLKKELTGLNHWVRAL--VAAQSYLYSGSYQTI-KIWDIRTLDCI 552
+ +K+W++ K K L+ + V A+ + S + SGSY + +IWD + C+
Sbjct: 145 FDETVKIWEV--KTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCL 202
Query: 553 HVLQTSGG---SVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYAL-AVI 608
L S + +I+ T +N + +WD ++T TGH Y + A
Sbjct: 203 KTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANF 262
Query: 609 STPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAV--SRGRLFSGAV--DST 664
S + S S D + +W++ Q L H V + A + + S A+ D T
Sbjct: 263 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKT 322
Query: 665 VKVW 668
+K+W
Sbjct: 323 IKLW 326
Score = 92.8 bits (229), Expect = 9e-19
Identities = 74/266 (27%), Positives = 127/266 (47%), Gaps = 19/266 (7%)
Query: 376 ILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTL 435
I G+YD K + T GH + + S L S S DKT+K+WD + KC KTL
Sbjct: 67 IWGAYDG----KYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDV-RSGKCLKTL 121
Query: 436 EGHDGIVLALCIQGCK--LYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLV--SSHNV 491
+GH V + SGS D T+ +W+++ + + T+ AH +PV + S ++
Sbjct: 122 KGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSL 181
Query: 492 LFSGSLKAI-KVWDIVGTELKLKKELTGLN---HWVRALVAAQSYLYSGSYQTIKIWDIR 547
+ SGS + ++WD + LK + N +V+ + L + T+K+WD
Sbjct: 182 IVSGSYDGLCRIWDAASGQC-LKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYS 240
Query: 548 TLDCIHVLQTSGGSVYSI----AVTNHH-IVCGTYENLIHVWDIESKEQVRTLTGHVGTV 602
C+ Y I +VT IV G+ +NL+++W++++KE V+ L GH V
Sbjct: 241 RGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 300
Query: 603 YALAVISTPDQTKVFSASYDRSLRVW 628
+ A T + + D+++++W
Sbjct: 301 ISAACHPTENLIASAALENDKTIKLW 326
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 91.7 bits (226), Expect = 2e-18
Identities = 80/319 (25%), Positives = 141/319 (44%), Gaps = 38/319 (11%)
Query: 376 ILGSYDPQQIFKCK----------GTFVGHQGPVWCLCVYS-MGDLLFSGSSDKTIKVWD 424
I GSYD CK T GH+ V+ + + GD + +GS DKT K+W
Sbjct: 108 ITGSYDRT----CKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWS 163
Query: 425 TCTTYKCQKTLEGHDGIVLALCI--QGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPV 482
T KC T GH ++ L Q + +GS D T +WDIQN ++V T+R H +
Sbjct: 164 V-ETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEI 222
Query: 483 CTLV--SSHNVLFSGSLK-AIKVWDI-VGTELKLKKELTGLNHWVRALVAAQSY----LY 534
+L +S + + +GS + VWD G ++ + + H A+ ++ +
Sbjct: 223 ISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNIL-----IGHCAEISSASFNWDCSLIL 277
Query: 535 SGSY-QTIKIWDIRTLDCIHVLQTSGGSVYSIAV--TNHHIVCGTYENLIHVWDIESKEQ 591
+GS +T K+WD C+ L + T I + + ++ +++
Sbjct: 278 TGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKC 337
Query: 592 VRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAV 651
+ L GH G + ++ P + + S D++ R+W C Q L H + + A
Sbjct: 338 IAKLEGHEGEISKISF--NPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAF 395
Query: 652 S-RGRL-FSGAVDSTVKVW 668
+ +G + +G+ D+T ++W
Sbjct: 396 NYKGNIVITGSKDNTCRIW 414
Score = 82.4 bits (202), Expect = 1e-15
Identities = 75/293 (25%), Positives = 131/293 (44%), Gaps = 30/293 (10%)
Query: 395 HQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQ---GCK 451
H P+ + + G +GS D+T K+WDT + + TLEGH +V A+ G K
Sbjct: 91 HILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEEL-NTLEGHRNVVYAIAFNNPYGDK 149
Query: 452 LYSGSADCTIIVWDIQNLQKVNTIRAHD--------NPVCTLVSSHNVLFSGSL-KAIKV 502
+ +GS D T +W ++ + +T R H NP TLV+ +GS+ K+
Sbjct: 150 IATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVA------TGSMDTTAKL 203
Query: 503 WDIVGTELKLKKELTGLNHWVRALVAAQSYLYSGSY-QTIKIWDIRTLDCIHVLQTSGGS 561
WDI E + + + +GS+ T+ +WD T +++L
Sbjct: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAE 263
Query: 562 VYSIAVT--NHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQT--KVF 617
+ S + I+ G+ + +WD + + V TLTGH + + S D T +
Sbjct: 264 ISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEI----LDSCFDYTGKLIA 319
Query: 618 SASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVS--RGRLFSGAVDSTVKVW 668
+AS D + R++S C L H+G ++ ++ + L +G+ D T ++W
Sbjct: 320 TASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW 372
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 89.4 bits (220), Expect = 1e-17
Identities = 77/259 (29%), Positives = 125/259 (48%), Gaps = 35/259 (13%)
Query: 391 TFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLAL--CIQ 448
T GH G V L + G +LFS S+DKT+ VWD+ T + K L+GH V + +
Sbjct: 104 TLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERV-KRLKGHTSFVNSCYPARR 162
Query: 449 GCKLY-SGSADCTIIVWDIQNLQKVNTIR-AHDNPVCTLVSSHNVLFSGSL-KAIKVWDI 505
G +L +GS D T+ +WDI+ + T + + T + + + SG + IKVWD+
Sbjct: 163 GPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDL 222
Query: 506 VGTELKL-----KKELTGLNHWVRALVAAQSYLYSGSY-QTIKIWDIRTL----DCIHVL 555
+L +TGL +L + SYL S + T+++WD+R C+ +
Sbjct: 223 RQNKLTYTMRGHADSVTGL-----SLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIF 277
Query: 556 QTSGGSVY---------SIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALA 606
Q G+V+ S + I G+ + ++VWD S+ + L GH G++ +A
Sbjct: 278 Q---GNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVA 334
Query: 607 VISTPDQTKVFSASYDRSL 625
PD+ + SAS D+ L
Sbjct: 335 F--HPDEPIIISASSDKRL 351
Score = 87.4 bits (215), Expect = 4e-17
Identities = 68/276 (24%), Positives = 121/276 (43%), Gaps = 24/276 (8%)
Query: 394 GHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLAL--CIQGCK 451
GH+G V+C + G L S D+ I +W+ TL+GH G V+ L G
Sbjct: 64 GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM 123
Query: 452 LYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHN----VLFSGSLKAIKVWDIVG 507
L+S S D T+ VWD + ++V ++ H + V + + V +K+WDI
Sbjct: 124 LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI-- 181
Query: 508 TELKLKKELTGLNHWVRALV-----AAQSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSV 562
+ K + + + L + + G IK+WD+R + ++ SV
Sbjct: 182 ---RKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSV 238
Query: 563 YSIAVTNH--HIVCGTYENLIHVWDIE---SKEQ-VRTLTGHVGTV--YALAVISTPDQT 614
+++++ +++ +N + VWD+ KE+ V+ G+V L +PD +
Sbjct: 239 TGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGS 298
Query: 615 KVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALA 650
K+ + S DR + VW + L H GS+ +A
Sbjct: 299 KIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVA 334
Score = 61.2 bits (147), Expect = 3e-09
Identities = 44/144 (30%), Positives = 69/144 (47%), Gaps = 9/144 (6%)
Query: 531 SYLYSGSY-QTIKIWDIRTLDCIHVLQTSGGSVYSI--AVTNHHIVC-GTYENLIHVWDI 586
S L+S S +T+ +WD T + + L+ V S A +VC G+ + + +WDI
Sbjct: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI 181
Query: 587 ESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSV 646
K ++T T LAV ++ S D ++VW + T T+ H SV
Sbjct: 182 RKKAAIQTFQN---TYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSV 238
Query: 647 TALAVSR--GRLFSGAVDSTVKVW 668
T L++S L S A+D+TV+VW
Sbjct: 239 TGLSLSSEGSYLLSNAMDNTVRVW 262
Score = 40.0 bits (92), Expect = 0.007
Identities = 28/96 (29%), Positives = 47/96 (48%), Gaps = 6/96 (6%)
Query: 577 YENLIHVWDIESK-EQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMIC 635
++ LI +W++ + TL GH G V L D + +FSAS D+++ VW +
Sbjct: 86 FDRLILLWNVYGDCDNYATLKGHSGAVMELHY--NTDGSMLFSASTDKTVAVWDSETGER 143
Query: 636 TQTLLRHQGSVTALAVSR---GRLFSGAVDSTVKVW 668
+ L H V + +R + +G+ D TVK+W
Sbjct: 144 VKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLW 179
>gi|11968023 zinc finger protein 106 homolog [Homo sapiens]
Length = 1883
Score = 87.8 bits (216), Expect = 3e-17
Identities = 77/316 (24%), Positives = 147/316 (46%), Gaps = 26/316 (8%)
Query: 365 LSHINARLNMGILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWD 424
+S I N + S +G+F GHQ V + ++ G+LL++ S+DKT++V++
Sbjct: 1500 ISSIKGSKNSSEISSEPGDDDEPTEGSFEGHQAAVNAIQIF--GNLLYTCSADKTVRVYN 1557
Query: 425 TCTTYKCQKTLEGHDGIVLALCI-----QGCKLYSGSADCTIIVWDIQNLQKVNTIRAHD 479
+ KC EGH V L + + LY+GS+D TI +++++ + V ++ D
Sbjct: 1558 -LVSRKCIGVFEGHTSKVNCLLVTQTSGKNAALYTGSSDHTIRCYNVKSRECVEQLQLED 1616
Query: 480 NPVCTLVSSHNVLFSGSLKAIKVWDIVGTELKLKKELTGLN-HWVRAL-------VAAQS 531
+C L S +L++G +V +K K L H RA+ A+
Sbjct: 1617 RVLC-LHSRWRILYAGLANG----TVVTFNIKNNKRLEIFECHGPRAVSCLATAQEGARK 1671
Query: 532 YLYSGSYQ-TIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKE 590
L GSY TI + D R + L+ ++ + V N + G+ + +H +I + E
Sbjct: 1672 LLVVGSYDCTISVRDARNGLLLRTLEGHSKTILCMKVVNDLVFSGSSDQSVHAHNIHTGE 1731
Query: 591 QVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALA 650
VR GH +A+ V++ + V +A D+ +RV+ + + Q H+ + +
Sbjct: 1732 LVRIYKGH---NHAVTVVNILGKVMV-TACLDKFVRVYELQSHDRLQVYGGHKDMIMCMT 1787
Query: 651 VSRGRLFSGAVDSTVK 666
+ + +++G D +++
Sbjct: 1788 IHKSMIYTGCYDGSIQ 1803
Score = 60.5 bits (145), Expect = 5e-09
Identities = 61/247 (24%), Positives = 112/247 (45%), Gaps = 19/247 (7%)
Query: 434 TLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPV-CTLVS----S 488
+ EGH V A+ I G LY+ SAD T+ V+++ + + + H + V C LV+
Sbjct: 1526 SFEGHQAAVNAIQIFGNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVTQTSGK 1585
Query: 489 HNVLFSGSL-KAIKVWDIVGTELKLKKELTGLNHWVRALVAAQSYLYSG-SYQTIKIWDI 546
+ L++GS I+ +++ E E L V L + LY+G + T+ ++I
Sbjct: 1586 NAALYTGSSDHTIRCYNVKSREC---VEQLQLEDRVLCLHSRWRILYAGLANGTVVTFNI 1642
Query: 547 RTLDCIHVLQTSGGSVYSIAVTNHH-----IVCGTYENLIHVWDIESKEQVRTLTGHVGT 601
+ + + + G S T +V G+Y+ I V D + +RTL GH T
Sbjct: 1643 KNNKRLEIFECHGPRAVSCLATAQEGARKLLVVGSYDCTISVRDARNGLLLRTLEGHSKT 1702
Query: 602 VYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAV 661
+ + V++ VFS S D+S+ ++ + H +VT + + + + +
Sbjct: 1703 ILCMKVVN----DLVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNILGKVMVTACL 1758
Query: 662 DSTVKVW 668
D V+V+
Sbjct: 1759 DKFVRVY 1765
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 84.3 bits (207), Expect = 3e-16
Identities = 94/360 (26%), Positives = 143/360 (39%), Gaps = 81/360 (22%)
Query: 380 YDPQQIFK------CKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQK 433
Y PQ IF+ C + GH V + G L SGS D T++ WD T
Sbjct: 92 YQPQAIFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETP-HF 150
Query: 434 TLEGHDGIVLALCIQ--GCKLYSGSADCTIIVWDIQNLQKVNTIRA-------------- 477
T +GH VL++ G KL SG + I++WD ++V A
Sbjct: 151 TCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPL 210
Query: 478 HDNPVCTLVSSHNVLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALV-AAQSYLYSG 536
H NP C V+S S ++++WD T + ++ LTG V L LYS
Sbjct: 211 HANPECRYVAS-----SSKDGSVRIWDT--TAGRCERILTGHTQSVTCLRWGGDGLLYSA 263
Query: 537 SY-QTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHH------------------------ 571
S +TIK+W LQ G V ++A++ +
Sbjct: 264 SQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQ 323
Query: 572 --------------------IVCGTYENLIHVWD-IESKEQVRTLTGHVGTVYALAVIST 610
+V G+ + + +W E K+ + +TGH + V+ +
Sbjct: 324 ELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQ--VLFS 381
Query: 611 PDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGR--LFSGAVDSTVKVW 668
PD V SAS+D+S+++W +L H +V +A S L SG+ DST+KVW
Sbjct: 382 PDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVW 441
Score = 73.2 bits (178), Expect = 7e-13
Identities = 71/266 (26%), Positives = 120/266 (45%), Gaps = 53/266 (19%)
Query: 413 SGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKL-YSGSADCTIIVWDIQNLQK 471
S S D ++++WDT T +C++ L GH V L G L YS S D TI VW +
Sbjct: 221 SSSKDGSVRIWDT-TAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVL 279
Query: 472 VNTIRAHDNPVCTL-VSSHNVLFSGSLK----AIKVWDIVGTELKLKKELTGLNHWVRA- 525
T++ H + V T+ +S+ L +G+ + ++ D+ G+ +LK+ + VR
Sbjct: 280 CRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQ 339
Query: 526 ----LVAAQS----YLYSGSY---------------------------------QTIKIW 544
LV+ +L+S + ++IK+W
Sbjct: 340 GPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLW 399
Query: 545 DIRTLDCIHVLQTSGGSVYSIA--VTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTV 602
D RT + L+ +VY IA + +V G+ ++ + VWD+++++ L GH V
Sbjct: 400 DGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEV 459
Query: 603 YALAVISTPDQTKVFSASYDRSLRVW 628
Y AV +PD +V S D+ LR+W
Sbjct: 460 Y--AVDWSPDGQRVASGGKDKCLRIW 483
Score = 44.3 bits (103), Expect = 4e-04
Identities = 35/129 (27%), Positives = 56/129 (43%), Gaps = 6/129 (4%)
Query: 380 YDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHD 439
+ P + K GHQ + + ++ S S DK+IK+WD T K +L GH
Sbjct: 356 WSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDG-RTGKYLASLRGHV 414
Query: 440 GIV--LALCIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTL---VSSHNVLFS 494
V +A L SGS+D T+ VWD++ + + H + V + V
Sbjct: 415 AAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASG 474
Query: 495 GSLKAIKVW 503
G K +++W
Sbjct: 475 GKDKCLRIW 483
>gi|38569484 kinesin family member 21A [Homo sapiens]
Length = 1661
Score = 84.0 bits (206), Expect = 4e-16
Identities = 91/372 (24%), Positives = 163/372 (43%), Gaps = 54/372 (14%)
Query: 343 NQSKLSEDLMEFRRDASMLNDE-LSHINARLNMGILGSYDPQQIFK-----CKGTFVGHQ 396
N+ +S+ ++D S +D LS ++ GI+ + + + C GH
Sbjct: 1275 NRLTVSQGNTSVQQDKSDESDSSLSEVHRSSRRGIINPFPASKGIRAFPLQCIHIAEGHT 1334
Query: 397 GPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLAL--CIQGCKLYS 454
V LCV S DLLF+GS D+T KVW+ T + +L GH V+++ C +++
Sbjct: 1335 KAV--LCVDSTDDLLFTGSKDRTCKVWNLVTGQEIM-SLGGHPNNVVSVKYCNYTSLVFT 1391
Query: 455 GSADCTIIVWDIQNLQK-VNTIRAHDN----PVCTLVSSHNV------------------ 491
S I VWDI++ K + T+ + C+ +S V
Sbjct: 1392 VSTSY-IKVWDIRDSAKCIRTLTSSGQVTLGDACSASTSRTVAIPSGENQINQIALNPTG 1450
Query: 492 --LFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALV-----AAQSYLYSGSYQT-IKI 543
L++ S A+++WD+ + +LTG V L + Q + +GS IK+
Sbjct: 1451 TFLYAASGNAVRMWDL--KRFQSTGKLTGHLGPVMCLTVDQISSGQDLIITGSKDHYIKM 1508
Query: 544 WDIR-----TLDCIHVLQTSG-GSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTL-T 596
+D+ T+ H + + ++ + ++ G+ +N I WD+ K+ ++ +
Sbjct: 1509 FDVTEGALGTVSPTHNFEPPHYDGIEALTIQGDNLFSGSRDNGIKKWDLTQKDLLQQVPN 1568
Query: 597 GHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRL 656
H V AL V+ PD + S L+VW+MD + + H + A+ V+ +
Sbjct: 1569 AHKDWVCALGVV--PDHPVLLSGCRGGILKVWNMDTFMPVGEMKGHDSPINAICVNSTHI 1626
Query: 657 FSGAVDSTVKVW 668
F+ A D TV++W
Sbjct: 1627 FTAADDRTVRIW 1638
Score = 42.0 bits (97), Expect = 0.002
Identities = 22/76 (28%), Positives = 39/76 (51%), Gaps = 1/76 (1%)
Query: 395 HQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYS 454
H+ V L V +L SG +KVW+ T+ ++GHD + A+C+ +++
Sbjct: 1570 HKDWVCALGVVPDHPVLLSGCRGGILKVWNM-DTFMPVGEMKGHDSPINAICVNSTHIFT 1628
Query: 455 GSADCTIIVWDIQNLQ 470
+ D T+ +W +NLQ
Sbjct: 1629 AADDRTVRIWKARNLQ 1644
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 79.3 bits (194), Expect = 1e-14
Identities = 76/288 (26%), Positives = 124/288 (43%), Gaps = 21/288 (7%)
Query: 392 FVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIV--LALCIQG 449
F H G V G +L +GS D + W+T + + L GH G V G
Sbjct: 17 FGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWR-LGGHTGPVKFCRFSPDG 75
Query: 450 CKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTL---VSSHNVLFSGSLKAIKVWDI- 505
S S DCT+ +WD+ + + ++ H V T+ S + G K + +WD+
Sbjct: 76 HLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQ 135
Query: 506 VGTELKLKKELTGLNHWVRA--LVAAQSYLYSGSY-QTIKIWDIRTLDCIHVLQTSGGSV 562
G L+L L G +++ + L +GS+ T+ IWD+R + Q G
Sbjct: 136 SGQMLRL---LVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHS 192
Query: 563 YSIAVTNHH----IVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFS 618
+I+ + + G+++ IH+W + + L GHV V ++A +PD+ + S
Sbjct: 193 ANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAF--SPDELWLAS 250
Query: 619 ASYDRSLRVWSMDNMICTQTL--LRHQGSVTALAVSRGRLFSGAVDST 664
A Y R ++VW + C +TL + A L SGA D T
Sbjct: 251 AGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
Score = 60.8 bits (146), Expect = 4e-09
Identities = 32/135 (23%), Positives = 71/135 (52%), Gaps = 8/135 (5%)
Query: 540 TIKIWDIRTLDCIHVLQTSGGSVYSIAVT--NHHIVCGTYENLIHVWDIESKEQVRTLTG 597
T+++WD+ C+ VL+ SV +++ + + + G ++ + +WD++S + +R L G
Sbjct: 86 TVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVG 145
Query: 598 HVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNM---ICTQTLLRHQGSVTALAVSR- 653
H ++ + +P + + S+D ++ +W + + + Q L H +++ L S
Sbjct: 146 HRDSIQSSDF--SPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSAS 203
Query: 654 GRLFSGAVDSTVKVW 668
G L SG+ D T+ +W
Sbjct: 204 GLLASGSWDKTIHIW 218
Score = 54.7 bits (130), Expect = 3e-07
Identities = 48/181 (26%), Positives = 82/181 (45%), Gaps = 15/181 (8%)
Query: 387 KCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALC 446
KC GHQ V + L SG DK + +WD + + + L GH + +
Sbjct: 96 KCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV-QSGQMLRLLVGHRDSIQSSD 154
Query: 447 IQ---GCKLYSGSADCTIIVWDIQNLQKVNTIRAHD----NPVCTLVSSHNVLFSGSL-K 498
C L +GS D T+ +WD++ + + +A + N C S+ +L SGS K
Sbjct: 155 FSPTVNC-LATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDK 213
Query: 499 AIKVWDIVGTELKLKKELTGLNHWVRALVAAQSYLY---SGSYQTIKIWDIRTLDCIHVL 555
I +W + L + +L G WV+++ + L+ +G + +K+WD T C+ L
Sbjct: 214 TIHIWKPTTSSLLI--QLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETL 271
Query: 556 Q 556
+
Sbjct: 272 K 272
Score = 46.6 bits (109), Expect = 7e-05
Identities = 34/114 (29%), Positives = 54/114 (47%), Gaps = 6/114 (5%)
Query: 559 GGSVYSIAVT--NHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKV 616
GG V S A + ++ G+ + ++ W+ S + + L GH G V +PD
Sbjct: 21 GGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRF--SPDGHLF 78
Query: 617 FSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVS--RGRLFSGAVDSTVKVW 668
SAS D ++R+W + C + L HQ SV ++ S +L SG D V +W
Sbjct: 79 ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLW 132
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 77.4 bits (189), Expect = 4e-14
Identities = 77/290 (26%), Positives = 124/290 (42%), Gaps = 19/290 (6%)
Query: 392 FVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCI--QG 449
F GH+ V C+ L SGS D + VW + + GH V + G
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR-FTGHKDAVTCVNFSPSG 73
Query: 450 CKLYSGSADCTIIVWDIQNLQKVNTI-RAHDNPVCTL---VSSHNVLFSGSLKAIKVWDI 505
L SGS D T+ +W + N++ +T+ RAH V ++ + + + K +KVW
Sbjct: 74 HLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW-- 130
Query: 506 VGTELKLKKELTGLNHWVRALVAA---QSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSV 562
K L+ +WVR + + + + +T+K+WD + +C+H GG V
Sbjct: 131 ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFV 190
Query: 563 YSIAV--TNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSAS 620
+ + I +N + VWD+ + ++ H V L+ P + +AS
Sbjct: 191 TYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF--HPSGNYLITAS 248
Query: 621 YDRSLRVWSMDNMICTQTLLRHQGSVTALAVSR-GRLF-SGAVDSTVKVW 668
D +L++ + TL HQG T +A SR G F SG D V VW
Sbjct: 249 SDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 43.1 bits (100), Expect = 8e-04
Identities = 30/122 (24%), Positives = 54/122 (44%), Gaps = 6/122 (4%)
Query: 387 KCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALC 446
+C ++ H G V + + G + + D T+KVWD T++ + + H V L
Sbjct: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV-RTHRLLQHYQLHSAAVNGLS 236
Query: 447 I--QGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLF---SGSLKAIK 501
G L + S+D T+ + D+ + + T+ H P T+ S + GS + +
Sbjct: 237 FHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVM 296
Query: 502 VW 503
VW
Sbjct: 297 VW 298
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 77.4 bits (189), Expect = 4e-14
Identities = 77/290 (26%), Positives = 124/290 (42%), Gaps = 19/290 (6%)
Query: 392 FVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCI--QG 449
F GH+ V C+ L SGS D + VW + + GH V + G
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR-FTGHKDAVTCVNFSPSG 73
Query: 450 CKLYSGSADCTIIVWDIQNLQKVNTI-RAHDNPVCTL---VSSHNVLFSGSLKAIKVWDI 505
L SGS D T+ +W + N++ +T+ RAH V ++ + + + K +KVW
Sbjct: 74 HLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW-- 130
Query: 506 VGTELKLKKELTGLNHWVRALVAA---QSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSV 562
K L+ +WVR + + + + +T+K+WD + +C+H GG V
Sbjct: 131 ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFV 190
Query: 563 YSIAV--TNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSAS 620
+ + I +N + VWD+ + ++ H V L+ P + +AS
Sbjct: 191 TYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF--HPSGNYLITAS 248
Query: 621 YDRSLRVWSMDNMICTQTLLRHQGSVTALAVSR-GRLF-SGAVDSTVKVW 668
D +L++ + TL HQG T +A SR G F SG D V VW
Sbjct: 249 SDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 43.1 bits (100), Expect = 8e-04
Identities = 30/122 (24%), Positives = 54/122 (44%), Gaps = 6/122 (4%)
Query: 387 KCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALC 446
+C ++ H G V + + G + + D T+KVWD T++ + + H V L
Sbjct: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV-RTHRLLQHYQLHSAAVNGLS 236
Query: 447 I--QGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLF---SGSLKAIK 501
G L + S+D T+ + D+ + + T+ H P T+ S + GS + +
Sbjct: 237 FHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVM 296
Query: 502 VW 503
VW
Sbjct: 297 VW 298
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 75.9 bits (185), Expect = 1e-13
Identities = 69/273 (25%), Positives = 123/273 (45%), Gaps = 13/273 (4%)
Query: 409 DLLFSGSSDKTIKVWD-TCTTYKCQKTLEGHDGIVLALCIQGCK--LYSGSADCTIIVWD 465
+ + +GS D +KVW Q +LEGH V+++ I S S D I +WD
Sbjct: 33 ETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWD 92
Query: 466 IQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKAIKVWDIVGTELKLKK-ELTGLNHWVR 524
++N +++ +I A TL S + + + + +I G E K+ L ++
Sbjct: 93 LENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFIL 152
Query: 525 ALVAAQS--YLYSGSYQ-TIKIWDIRTLDCIHVLQTSGGSVYSIAVT--NHHIVCGTYEN 579
++ + YL SG+ I I+DI T +H L+ + S+ + + +V + +
Sbjct: 153 SIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDG 212
Query: 580 LIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTL 639
I ++D++ TL+GH V L V PD T S+S D+S++VW + C T
Sbjct: 213 YIKIYDVQHANLAGTLSGHASWV--LNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF 270
Query: 640 LRHQGSVTALAV--SRGRLFSGAVDSTVKVWTC 670
HQ V + + ++ S D + ++ C
Sbjct: 271 FDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDC 303
Score = 40.4 bits (93), Expect = 0.005
Identities = 30/94 (31%), Positives = 40/94 (42%), Gaps = 3/94 (3%)
Query: 391 TFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVL--ALCIQ 448
T GH P+ L LL + S D IK++D TL GH VL A C
Sbjct: 185 TLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDV-QHANLAGTLSGHASWVLNVAFCPD 243
Query: 449 GCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPV 482
S S+D ++ VWD+ V+T H + V
Sbjct: 244 DTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQV 277
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 74.3 bits (181), Expect = 3e-13
Identities = 72/280 (25%), Positives = 116/280 (41%), Gaps = 47/280 (16%)
Query: 394 GHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCI--QGCK 451
GH G V C+ V +GS+D+TIK+WD + K + +L GH V + + +
Sbjct: 202 GHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASG-KLKLSLTGHISTVRGVIVSTRSPY 260
Query: 452 LYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKAIKVWDIVGTELK 511
L+S D + WD++ N + H + G L A+ D+ T
Sbjct: 261 LFSCGEDKQVKCWDLE----YNKVIRH--------------YHGHLSAVYGLDLHPT--- 299
Query: 512 LKKELTGLNHWVRALVAAQSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSVYSI--AVTN 569
+ LV T +IWD+RT +H L +V ++
Sbjct: 300 -----------IDVLVTC------SRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAE 342
Query: 570 HHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWS 629
I+ G+++ I +WD+ + + TLT H +V AV+ P S S D +++ W
Sbjct: 343 PQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSV--RAVVLHPRHYTFASGSPD-NIKQWK 399
Query: 630 MDNMICTQTLLRHQGSVTALAV-SRGRLFSGAVDSTVKVW 668
+ Q L H + L V S G L SGA + T+ +W
Sbjct: 400 FPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLW 439
Score = 67.0 bits (162), Expect = 5e-11
Identities = 67/269 (24%), Positives = 114/269 (42%), Gaps = 23/269 (8%)
Query: 387 KCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALC 446
K K + GH V + V + LFS DK +K WD K + GH V L
Sbjct: 237 KLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWD-LEYNKVIRHYHGHLSAVYGLD 295
Query: 447 IQGC--KLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTL---VSSHNVLFSGSLKAIK 501
+ L + S D T +WD++ V+T+ H N V T+ + ++ I+
Sbjct: 296 LHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIR 355
Query: 502 VWDIVGTELKLKKELTGLNHWVRALVA-AQSYLY-SGSYQTIKIWDIRTLDCIHVLQTSG 559
+WD+V K + LT VRA+V + Y + SGS IK W I L
Sbjct: 356 LWDLVAG--KTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHN 413
Query: 560 GSVYSIAVTNHHI-VCGTYENLIHVWD---------IESKEQVRTLTGHVGTVYALAVIS 609
+ ++ V + + V G +H+WD + + Q +L G ++A A
Sbjct: 414 AIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESG-IFACAF-- 470
Query: 610 TPDQTKVFSASYDRSLRVWSMDNMICTQT 638
++++ +A D++++V+ D+ +T
Sbjct: 471 DQSESRLLTAEADKTIKVYREDDTATEET 499
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 72.0 bits (175), Expect = 2e-12
Identities = 76/313 (24%), Positives = 124/313 (39%), Gaps = 48/313 (15%)
Query: 394 GHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQ----- 448
GH+ V+ + DLL SGS D T ++W+ + + G +VL CI+
Sbjct: 177 GHESEVFICAWNPVSDLLASGSGDSTARIWNLN-----ENSNGGSTQLVLRHCIREGGHD 231
Query: 449 ---------------GCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLV---SSHN 490
G L GS D +W +N +T+ H P+ L +
Sbjct: 232 VPSNKDVTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNY 290
Query: 491 VLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRAL-VAAQSYLYSGSYQTIKIWDIRTL 549
VL +G K +WD E K + H AL V Q+ + S T + L
Sbjct: 291 VLSAGVDKTTIIWDAHTGEAKQQFPF----HSAPALDVDWQNNMTFASCSTDMCIHVCRL 346
Query: 550 DCIHVLQTSGGSVYSIAVTNHH-----IVCGTYENLIHVWDIESKEQVRTLTGHVGTVYA 604
C H ++T G + + + + + +W ++ V L H +Y
Sbjct: 347 GCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYT 406
Query: 605 LAVISTPDQTK-------VFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRG--R 655
+ T T + SAS+D ++R+W ++ +CT TL++HQ V ++A S
Sbjct: 407 IKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKY 466
Query: 656 LFSGAVDSTVKVW 668
L SG+ D V +W
Sbjct: 467 LASGSFDKYVHIW 479
Score = 63.5 bits (153), Expect = 6e-10
Identities = 59/241 (24%), Positives = 103/241 (42%), Gaps = 22/241 (9%)
Query: 406 SMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCI--QGCKLYSGSADCTIIV 463
S G LL GS D ++W TL H G + AL +G + S D T I+
Sbjct: 245 SDGTLLAMGSYDGFARIWTE--NGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTII 302
Query: 464 WDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKAIKVWDI-VGTELKLKKELTGLNHW 522
WD + H P + +N+ F+ + + +G + +K G +
Sbjct: 303 WDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKT-FQGHTNE 361
Query: 523 VRALVAAQSYLYSGSYQ---TIKIWDIRTLDCIHVLQTSGGSVYSI-------AVTNHH- 571
V A+ S + S T+KIW ++ C+H LQ +Y+I A +N +
Sbjct: 362 VNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNS 421
Query: 572 ---IVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVW 628
+ ++++ + +WD+E TL H VY++A +PD + S S+D+ + +W
Sbjct: 422 SIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAF--SPDGKYLASGSFDKYVHIW 479
Query: 629 S 629
+
Sbjct: 480 N 480
Score = 56.6 bits (135), Expect = 7e-08
Identities = 57/245 (23%), Positives = 100/245 (40%), Gaps = 22/245 (8%)
Query: 377 LGSYDP-QQIFKCKGTFVG----HQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKC 431
+GSYD +I+ G H+GP++ L G+ + S DKT +WD T +
Sbjct: 252 MGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTG-EA 310
Query: 432 QKTLEGHDGIVLALCIQGCKLYSG-SADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHN 490
++ H L + Q ++ S D I V + V T + H N V + +
Sbjct: 311 KQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPS 370
Query: 491 VLFSGSLK---AIKVW----DIVGTELKLKKELTGLNHWVRALVAAQS-----YLYSGSY 538
+ S +K+W D +L+ + W A + L S S+
Sbjct: 371 GMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASF 430
Query: 539 Q-TIKIWDIRTLDCIHVLQTSGGSVYSIAVT--NHHIVCGTYENLIHVWDIESKEQVRTL 595
T+++WD+ C H L VYS+A + ++ G+++ +H+W+ +S V +
Sbjct: 431 DSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSY 490
Query: 596 TGHVG 600
G G
Sbjct: 491 QGTGG 495
Score = 35.8 bits (81), Expect = 0.13
Identities = 24/81 (29%), Positives = 42/81 (51%), Gaps = 4/81 (4%)
Query: 388 CKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALC- 446
C T + HQ PV+ + G L SGS DK + +W+T + + +G GI +C
Sbjct: 444 CTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNT-QSGSLVHSYQGTGGI-FEVCW 501
Query: 447 -IQGCKLYSGSADCTIIVWDI 466
+G K+ + ++D ++ V D+
Sbjct: 502 NARGDKVGASASDGSVCVLDL 522
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 72.0 bits (175), Expect = 2e-12
Identities = 76/313 (24%), Positives = 124/313 (39%), Gaps = 48/313 (15%)
Query: 394 GHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQ----- 448
GH+ V+ + DLL SGS D T ++W+ + + G +VL CI+
Sbjct: 177 GHESEVFICAWNPVSDLLASGSGDSTARIWNLN-----ENSNGGSTQLVLRHCIREGGHD 231
Query: 449 ---------------GCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLV---SSHN 490
G L GS D +W +N +T+ H P+ L +
Sbjct: 232 VPSNKDVTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNY 290
Query: 491 VLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRAL-VAAQSYLYSGSYQTIKIWDIRTL 549
VL +G K +WD E K + H AL V Q+ + S T + L
Sbjct: 291 VLSAGVDKTTIIWDAHTGEAKQQFPF----HSAPALDVDWQNNMTFASCSTDMCIHVCRL 346
Query: 550 DCIHVLQTSGGSVYSIAVTNHH-----IVCGTYENLIHVWDIESKEQVRTLTGHVGTVYA 604
C H ++T G + + + + + +W ++ V L H +Y
Sbjct: 347 GCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYT 406
Query: 605 LAVISTPDQTK-------VFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRG--R 655
+ T T + SAS+D ++R+W ++ +CT TL++HQ V ++A S
Sbjct: 407 IKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKY 466
Query: 656 LFSGAVDSTVKVW 668
L SG+ D V +W
Sbjct: 467 LASGSFDKYVHIW 479
Score = 63.5 bits (153), Expect = 6e-10
Identities = 59/241 (24%), Positives = 103/241 (42%), Gaps = 22/241 (9%)
Query: 406 SMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCI--QGCKLYSGSADCTIIV 463
S G LL GS D ++W TL H G + AL +G + S D T I+
Sbjct: 245 SDGTLLAMGSYDGFARIWTE--NGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTII 302
Query: 464 WDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKAIKVWDI-VGTELKLKKELTGLNHW 522
WD + H P + +N+ F+ + + +G + +K G +
Sbjct: 303 WDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKT-FQGHTNE 361
Query: 523 VRALVAAQSYLYSGSYQ---TIKIWDIRTLDCIHVLQTSGGSVYSI-------AVTNHH- 571
V A+ S + S T+KIW ++ C+H LQ +Y+I A +N +
Sbjct: 362 VNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNS 421
Query: 572 ---IVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVW 628
+ ++++ + +WD+E TL H VY++A +PD + S S+D+ + +W
Sbjct: 422 SIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAF--SPDGKYLASGSFDKYVHIW 479
Query: 629 S 629
+
Sbjct: 480 N 480
Score = 56.6 bits (135), Expect = 7e-08
Identities = 57/245 (23%), Positives = 100/245 (40%), Gaps = 22/245 (8%)
Query: 377 LGSYDP-QQIFKCKGTFVG----HQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKC 431
+GSYD +I+ G H+GP++ L G+ + S DKT +WD T +
Sbjct: 252 MGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTG-EA 310
Query: 432 QKTLEGHDGIVLALCIQGCKLYSG-SADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHN 490
++ H L + Q ++ S D I V + V T + H N V + +
Sbjct: 311 KQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPS 370
Query: 491 VLFSGSLK---AIKVW----DIVGTELKLKKELTGLNHWVRALVAAQS-----YLYSGSY 538
+ S +K+W D +L+ + W A + L S S+
Sbjct: 371 GMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASF 430
Query: 539 Q-TIKIWDIRTLDCIHVLQTSGGSVYSIAVT--NHHIVCGTYENLIHVWDIESKEQVRTL 595
T+++WD+ C H L VYS+A + ++ G+++ +H+W+ +S V +
Sbjct: 431 DSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSY 490
Query: 596 TGHVG 600
G G
Sbjct: 491 QGTGG 495
Score = 35.8 bits (81), Expect = 0.13
Identities = 24/81 (29%), Positives = 42/81 (51%), Gaps = 4/81 (4%)
Query: 388 CKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALC- 446
C T + HQ PV+ + G L SGS DK + +W+T + + +G GI +C
Sbjct: 444 CTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNT-QSGSLVHSYQGTGGI-FEVCW 501
Query: 447 -IQGCKLYSGSADCTIIVWDI 466
+G K+ + ++D ++ V D+
Sbjct: 502 NARGDKVGASASDGSVCVLDL 522
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 72.0 bits (175), Expect = 2e-12
Identities = 76/313 (24%), Positives = 124/313 (39%), Gaps = 48/313 (15%)
Query: 394 GHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQ----- 448
GH+ V+ + DLL SGS D T ++W+ + + G +VL CI+
Sbjct: 177 GHESEVFICAWNPVSDLLASGSGDSTARIWNLN-----ENSNGGSTQLVLRHCIREGGHD 231
Query: 449 ---------------GCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLV---SSHN 490
G L GS D +W +N +T+ H P+ L +
Sbjct: 232 VPSNKDVTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGNY 290
Query: 491 VLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRAL-VAAQSYLYSGSYQTIKIWDIRTL 549
VL +G K +WD E K + H AL V Q+ + S T + L
Sbjct: 291 VLSAGVDKTTIIWDAHTGEAKQQFPF----HSAPALDVDWQNNMTFASCSTDMCIHVCRL 346
Query: 550 DCIHVLQTSGGSVYSIAVTNHH-----IVCGTYENLIHVWDIESKEQVRTLTGHVGTVYA 604
C H ++T G + + + + + +W ++ V L H +Y
Sbjct: 347 GCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYT 406
Query: 605 LAVISTPDQTK-------VFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRG--R 655
+ T T + SAS+D ++R+W ++ +CT TL++HQ V ++A S
Sbjct: 407 IKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKY 466
Query: 656 LFSGAVDSTVKVW 668
L SG+ D V +W
Sbjct: 467 LASGSFDKYVHIW 479
Score = 63.5 bits (153), Expect = 6e-10
Identities = 59/241 (24%), Positives = 103/241 (42%), Gaps = 22/241 (9%)
Query: 406 SMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCI--QGCKLYSGSADCTIIV 463
S G LL GS D ++W TL H G + AL +G + S D T I+
Sbjct: 245 SDGTLLAMGSYDGFARIWTE--NGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTII 302
Query: 464 WDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKAIKVWDI-VGTELKLKKELTGLNHW 522
WD + H P + +N+ F+ + + +G + +K G +
Sbjct: 303 WDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKT-FQGHTNE 361
Query: 523 VRALVAAQSYLYSGSYQ---TIKIWDIRTLDCIHVLQTSGGSVYSI-------AVTNHH- 571
V A+ S + S T+KIW ++ C+H LQ +Y+I A +N +
Sbjct: 362 VNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNS 421
Query: 572 ---IVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVW 628
+ ++++ + +WD+E TL H VY++A +PD + S S+D+ + +W
Sbjct: 422 SIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAF--SPDGKYLASGSFDKYVHIW 479
Query: 629 S 629
+
Sbjct: 480 N 480
Score = 56.6 bits (135), Expect = 7e-08
Identities = 57/245 (23%), Positives = 100/245 (40%), Gaps = 22/245 (8%)
Query: 377 LGSYDP-QQIFKCKGTFVG----HQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKC 431
+GSYD +I+ G H+GP++ L G+ + S DKT +WD T +
Sbjct: 252 MGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTG-EA 310
Query: 432 QKTLEGHDGIVLALCIQGCKLYSG-SADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHN 490
++ H L + Q ++ S D I V + V T + H N V + +
Sbjct: 311 KQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPS 370
Query: 491 VLFSGSLK---AIKVW----DIVGTELKLKKELTGLNHWVRALVAAQS-----YLYSGSY 538
+ S +K+W D +L+ + W A + L S S+
Sbjct: 371 GMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASF 430
Query: 539 Q-TIKIWDIRTLDCIHVLQTSGGSVYSIAVT--NHHIVCGTYENLIHVWDIESKEQVRTL 595
T+++WD+ C H L VYS+A + ++ G+++ +H+W+ +S V +
Sbjct: 431 DSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSY 490
Query: 596 TGHVG 600
G G
Sbjct: 491 QGTGG 495
Score = 35.8 bits (81), Expect = 0.13
Identities = 24/81 (29%), Positives = 42/81 (51%), Gaps = 4/81 (4%)
Query: 388 CKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALC- 446
C T + HQ PV+ + G L SGS DK + +W+T + + +G GI +C
Sbjct: 444 CTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNT-QSGSLVHSYQGTGGI-FEVCW 501
Query: 447 -IQGCKLYSGSADCTIIVWDI 466
+G K+ + ++D ++ V D+
Sbjct: 502 NARGDKVGASASDGSVCVLDL 522
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 70.5 bits (171), Expect = 5e-12
Identities = 41/126 (32%), Positives = 65/126 (51%), Gaps = 7/126 (5%)
Query: 390 GTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVL--ALCI 447
G F GH+ +WC+ M +L + S+D TIK+W + C KT EGHD VL A
Sbjct: 515 GVFSGHRRGLWCVQFSPMDQVLATASADGTIKLW-ALQDFSCLKTFEGHDASVLKVAFVS 573
Query: 448 QGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPV----CTLVSSHNVLFSGSLKAIKVW 503
+G +L S +D + +W I+N + V T+ AH++ V C+ + H + + + I
Sbjct: 574 RGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWK 633
Query: 504 DIVGTE 509
D+ E
Sbjct: 634 DVTEAE 639
Score = 67.8 bits (164), Expect = 3e-11
Identities = 69/277 (24%), Positives = 112/277 (40%), Gaps = 32/277 (11%)
Query: 357 DASMLNDELSHINARLNMGILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSS 416
D L E SH+ N L ++ Q C+ GH V L V+ G L S +
Sbjct: 339 DVRFLGPEDSHVVVASNSPCLKVFE-LQTSACQ-ILHGHTDIVLALDVFRKGWLFASCAK 396
Query: 417 DKTIKVW--DTCTTYKCQKTLEGHDGIVLALCIQGCK---LYSGSADCTIIVWDIQN--- 468
D+++++W + C GH V +C K L +GS DCT+ +W +
Sbjct: 397 DQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALL 456
Query: 469 ------------LQKVNTIRAHDNPVCTLVSSHN--VLFSGSL-KAIKVWDIVGTELK-- 511
LQ T R HD + ++ + N +L +GS + K+W + +L
Sbjct: 457 SKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGV 516
Query: 512 LKKELTGLNHWVRALVAAQSYLYSGSYQ-TIKIWDIRTLDCIHVLQTSGGSVYSIAVTNH 570
GL W L + S TIK+W ++ C+ + SV +A +
Sbjct: 517 FSGHRRGL--WCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSR 574
Query: 571 --HIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYAL 605
++ + L+ +W I++ E VRTL H V+ L
Sbjct: 575 GTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGL 611
Score = 65.1 bits (157), Expect = 2e-10
Identities = 71/302 (23%), Positives = 122/302 (40%), Gaps = 34/302 (11%)
Query: 395 HQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQG----C 450
H PV + LL +G D ++VWD Y G G+V +
Sbjct: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHH-FRGSPGVVHLVAFHPDPTRL 166
Query: 451 KLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSS---HNVLFSGSLKAIKVWDIVG 507
L+S + D I VW +Q+ + + AH + V +L S H +L SG K +WD+
Sbjct: 167 LLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQS 226
Query: 508 TELKLKKELTGLNHWVRALVAAQS--------------YLYSGSYQTIKIWDIRTLDCIH 553
+ + V A V +L +G T+++W+ + C++
Sbjct: 227 CQ---ATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVY 283
Query: 554 VLQTSGG-----SVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVI 608
G + ++A T ++ T ++ + +++ S + G+ V + +
Sbjct: 284 TQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFL 343
Query: 609 STPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSR-GRLF-SGAVDSTVK 666
P+ + V AS L+V+ + C Q L H V AL V R G LF S A D +V+
Sbjct: 344 G-PEDSHVVVASNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRKGWLFASCAKDQSVR 401
Query: 667 VW 668
+W
Sbjct: 402 IW 403
Score = 57.8 bits (138), Expect = 3e-08
Identities = 73/290 (25%), Positives = 122/290 (42%), Gaps = 38/290 (13%)
Query: 410 LLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIV--LALCIQGCKLYSGSADCTIIVWDIQ 467
LLFS ++D I+VW + C L H V LA G + S D I+WD+Q
Sbjct: 167 LLFSSATDAAIRVW-SLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQ 225
Query: 468 NLQKVNTIRAHDN----------PVCTL-VSSHNVLF--SGSLKAIKVWDI-----VGTE 509
+ Q T+ ++ PV L V S + F +G ++VW+ V T+
Sbjct: 226 SCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQ 285
Query: 510 LKLKKELTGLNHWVRALVAAQSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGS-----VYS 564
+ L H A A + + + +++ R+L Q +G S V
Sbjct: 286 AQPPGPGQELTHCTLAHTAGVVLTATADHNLL-LYEARSLRLQK--QFAGYSEEVLDVRF 342
Query: 565 IAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRS 624
+ + H+V + + V+++++ + L GH V AL V S + D+S
Sbjct: 343 LGPEDSHVVVASNSPCLKVFELQTSA-CQILHGHTDIVLALDVFRKG--WLFASCAKDQS 399
Query: 625 LRVWSMDN---MICTQTLLRHQGSVTALAVSRGR---LFSGAVDSTVKVW 668
+R+W M+ ++C H SV + SR + L +G+ D TVK+W
Sbjct: 400 VRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLW 449
Score = 53.5 bits (127), Expect = 6e-07
Identities = 38/147 (25%), Positives = 63/147 (42%), Gaps = 12/147 (8%)
Query: 524 RALVAAQSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHV 583
RAL+ AQ GS ++W + T+ + + T+ + G + + V
Sbjct: 86 RALLLAQWAWQEGS--VTRLWK--------AIHTAPVATMAFDPTSTLLATGGCDGAVRV 135
Query: 584 WDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQ 643
WDI G G V+ +A P + +FS++ D ++RVWS+ + C L H
Sbjct: 136 WDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHY 195
Query: 644 GSVTALAVSRG--RLFSGAVDSTVKVW 668
+VT+LA S + S D +W
Sbjct: 196 SAVTSLAFSADGHTMLSSGRDKICIIW 222
Score = 45.1 bits (105), Expect = 2e-04
Identities = 28/83 (33%), Positives = 41/83 (49%), Gaps = 3/83 (3%)
Query: 384 QIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVL 443
Q F C TF GH V + S G L S SD +K+W T +C +TL+ H+ V
Sbjct: 551 QDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLW-TIKNNECVRTLDAHEDKVW 609
Query: 444 AL-CIQ-GCKLYSGSADCTIIVW 464
L C + +G++D +I+W
Sbjct: 610 GLHCSRLDDHALTGASDSRVILW 632
Score = 29.6 bits (65), Expect = 9.4
Identities = 25/113 (22%), Positives = 46/113 (40%), Gaps = 5/113 (4%)
Query: 561 SVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSAS 620
+ + ++ N +V + L+ W + R L + T + P T + +
Sbjct: 70 TAFDLSPDNEVLVTASRALLLAQWAWQEGSVTR-LWKAIHTAPVATMAFDPTSTLLATGG 128
Query: 621 YDRSLRVWSMDNMICTQTLLRHQGSVTALAV----SRGRLFSGAVDSTVKVWT 669
D ++RVW + T G V +A +R LFS A D+ ++VW+
Sbjct: 129 CDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWS 181
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 70.1 bits (170), Expect = 6e-12
Identities = 57/239 (23%), Positives = 107/239 (44%), Gaps = 9/239 (3%)
Query: 438 HDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSL 497
H ++L + L S +AD ++ +W + + + V I H V ++ + F G+
Sbjct: 282 HPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTT 341
Query: 498 ---KAIKVWDIVGTELKLKKELTGLNHWVRALVAAQSYLYSGSYQTI-KIWDIRTLDCIH 553
++ ++WD+ E L +E + + A S +G ++WD+RT CI
Sbjct: 342 CYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIM 401
Query: 554 VLQTSGGSVYSI--AVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTP 611
L+ +Y I + +HI G+ +N VWD+ + V T+ H V +
Sbjct: 402 FLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVK-FEPI 460
Query: 612 DQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSR-GRLFSG-AVDSTVKVW 668
+ + +YD + ++W+ +TL H+G V L +S G+L + + D T K+W
Sbjct: 461 HGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 61.6 bits (148), Expect = 2e-09
Identities = 53/230 (23%), Positives = 97/230 (42%), Gaps = 31/230 (13%)
Query: 463 VWDIQNLQKVNTIRAHDNPVCTLV-----------SSHNVLFSGSLKAIKVWDIVGTELK 511
+W + + ++T+R H+ V +V N+ + ++K+W + E
Sbjct: 257 LWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPV 316
Query: 512 LKKELTGLNHWVRALVAAQSYLYSGSY-------QTIKIWDIRTLDCIHVLQTSGGSVYS 564
E H VR VA + SG + ++ ++WD+ + I + VY
Sbjct: 317 ADIE----GHTVR--VARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYD 370
Query: 565 IAVTNHHIVCGT--YENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYD 622
IA + GT + VWD+ + + L GH+ +Y + +P+ + + S D
Sbjct: 371 IAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINF--SPNGYHIATGSGD 428
Query: 623 RSLRVWSMDNMICTQTLLRHQGSVTAL---AVSRGRLFSGAVDSTVKVWT 669
+ +VW + C T+ HQ VT + + L +GA D+T K+WT
Sbjct: 429 NTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWT 478
Score = 57.8 bits (138), Expect = 3e-08
Identities = 57/232 (24%), Positives = 102/232 (43%), Gaps = 22/232 (9%)
Query: 411 LFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSA--DCTIIVWDIQN 468
L S ++D ++K+W + + + +EGH V + + G+ D + +WD++
Sbjct: 296 LASCAADGSVKLW-SLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEA 354
Query: 469 LQKVNTIRAHDNPVCTLV--SSHNVLFSGSLKAI-KVWD------IVGTELKLKKELTGL 519
+++ H V + ++ +G L A +VWD I+ E LK E+ G+
Sbjct: 355 QEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLK-EIYGI 413
Query: 520 NHWVRALVAAQSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHH---IVCGT 576
N A SG T K+WD+R C++ + V + H ++ G
Sbjct: 414 NFSPNGYHIATG---SGD-NTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGA 469
Query: 577 YENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVW 628
Y+N +W ++TL GH G V L + S D + + SYDR+ ++W
Sbjct: 470 YDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISS--DGQLIATCSYDRTFKLW 519
Score = 45.4 bits (106), Expect = 2e-04
Identities = 31/91 (34%), Positives = 44/91 (48%), Gaps = 3/91 (3%)
Query: 394 GHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQ--GCK 451
GH V+ + + G L +G D +VWD T +C LEGH + + G
Sbjct: 363 GHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDL-RTGRCIMFLEGHLKEIYGINFSPNGYH 421
Query: 452 LYSGSADCTIIVWDIQNLQKVNTIRAHDNPV 482
+ +GS D T VWD++ + V TI AH N V
Sbjct: 422 IATGSGDNTCKVWDLRQRRCVYTIPAHQNLV 452
Score = 39.7 bits (91), Expect = 0.009
Identities = 32/123 (26%), Positives = 52/123 (42%), Gaps = 7/123 (5%)
Query: 387 KCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLAL- 445
+C GH ++ + G + +GS D T KVWD +C T+ H +V +
Sbjct: 398 RCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWD-LRQRRCVYTIPAHQNLVTGVK 456
Query: 446 --CIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTL-VSSHNVLFSGSL--KAI 500
I G L +G+ D T +W + T+ H+ V L +SS L + +
Sbjct: 457 FEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTF 516
Query: 501 KVW 503
K+W
Sbjct: 517 KLW 519
>gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens]
Length = 1051
Score = 70.1 bits (170), Expect = 6e-12
Identities = 46/146 (31%), Positives = 70/146 (47%), Gaps = 3/146 (2%)
Query: 392 FVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCK 451
F GH G V L + + L SGS D +I+ WD + C + GH G + + + +
Sbjct: 449 FRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGV-CTRIFGGHQGTITCMDLCKNR 507
Query: 452 LYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKAIKVWDIVGTELK 511
L SG DC + VWD+ + + T R D + T ++ ++ S +KVW I +
Sbjct: 508 LVSGGRDCQVKVWDVDTGKCLKTFRHKDPILATRINDTYIVSSCERGLVKVWHIAMAQ-- 565
Query: 512 LKKELTGLNHWVRALVAAQSYLYSGS 537
L K L+G V+ L Q +L SGS
Sbjct: 566 LVKTLSGHEGAVKCLFFDQWHLLSGS 591
Score = 64.3 bits (155), Expect = 3e-10
Identities = 45/150 (30%), Positives = 76/150 (50%), Gaps = 15/150 (10%)
Query: 520 NHWVRALVAAQSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYEN 579
N + ++ + ++ G+Y + D T D V+ SGG + IAV+++
Sbjct: 385 NEETQQVLIEERNVFCGTYNVRILSD--TWDQNRVIHYSGGDL--IAVSSNR-------- 432
Query: 580 LIHVWDIESKEQVRT-LTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQT 638
IH+ DI + + GH G+V AL + ++ + S SYD S+R W + + +CT+
Sbjct: 433 KIHLLDIIQVKAIPVEFRGHAGSVRALFLCE--EENFLLSGSYDLSIRYWDLKSGVCTRI 490
Query: 639 LLRHQGSVTALAVSRGRLFSGAVDSTVKVW 668
HQG++T + + + RL SG D VKVW
Sbjct: 491 FGGHQGTITCMDLCKNRLVSGGRDCQVKVW 520
Score = 61.6 bits (148), Expect = 2e-09
Identities = 45/186 (24%), Positives = 90/186 (48%), Gaps = 9/186 (4%)
Query: 487 SSHNVLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALVAAQ--SYLYSGSYQ-TIKI 543
S +++ S + I + DI+ + + E G VRAL + ++L SGSY +I+
Sbjct: 421 SGGDLIAVSSNRKIHLLDIIQVKA-IPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRY 479
Query: 544 WDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVY 603
WD+++ C + G++ + + + +V G + + VWD+++ + ++T H +
Sbjct: 480 WDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPIL 538
Query: 604 ALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDS 663
A + + T + S+ ++VW + +TL H+G+V L + L SG+ D
Sbjct: 539 ATRI----NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDG 594
Query: 664 TVKVWT 669
V W+
Sbjct: 595 LVMAWS 600
Score = 40.0 bits (92), Expect = 0.007
Identities = 33/117 (28%), Positives = 43/117 (36%), Gaps = 40/117 (34%)
Query: 388 CKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCT-------------------- 427
C F GHQG + C+ + + L SG D +KVWD T
Sbjct: 487 CTRIFGGHQGTITCMDLCK--NRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILATRIND 544
Query: 428 TY---KCQ---------------KTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDI 466
TY C+ KTL GH+G V L L SGS D ++ W +
Sbjct: 545 TYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSM 601
Score = 31.2 bits (69), Expect = 3.2
Identities = 24/88 (27%), Positives = 40/88 (45%), Gaps = 2/88 (2%)
Query: 391 TFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGC 450
T GH+G V CL + LL SGS+D + W Y+ H VL + +
Sbjct: 569 TLSGHEGAVKCL-FFDQWHLL-SGSTDGLVMAWSMVGKYERCLMAFKHPKEVLDVSLLFL 626
Query: 451 KLYSGSADCTIIVWDIQNLQKVNTIRAH 478
++ S AD I +++ N + ++A+
Sbjct: 627 RVISACADGKIRIYNFLNGNCMKVLKAN 654
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.133 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,542,656
Number of Sequences: 37866
Number of extensions: 1228654
Number of successful extensions: 7577
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 321
Number of HSP's successfully gapped in prelim test: 254
Number of HSP's that attempted gapping in prelim test: 5033
Number of HSP's gapped (non-prelim): 1636
length of query: 670
length of database: 18,247,518
effective HSP length: 109
effective length of query: 561
effective length of database: 14,120,124
effective search space: 7921389564
effective search space used: 7921389564
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.