Guide to the Human Genome
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Name: MLH1 Sequence: fasta or formatted (756aa) NCBI GI: 4557757
Description:

MutL protein homolog 1

Referenced in:

DNases, Recombination, and DNA Repair
Spindle, M phase, and Meiosis

Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             6.6         50           2
 C cysteine            1.5         11           1
 D aspartate           4.5         34           2
 E glutamate           9.3         70           2
 F phenylalanine       3.4         26           1
 G glycine             5.3         40           2
 H histidine           2.5         19           1
 I isoleucine          6.3         48           2
 K lysine              6.2         47           3
 L leucine            10.1         76           2
 M methionine          1.9         14           1
 N asparagine          4.4         33           1
 P proline             4.5         34           2
 Q glutamine           4.0         30           2
 R arginine            4.8         36           3
 S serine              9.1         69           3
 T threonine           6.0         45           2
 V valine              6.1         46           2
 W tryptophan          0.7          5           1
 Y tyrosine            3.0         23           1
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   MutL protein homolog 1 
PMS2                  0.097   PMS2 postmeiotic segregation increased 2 isoform a [H...
PMS1                  0.072   postmeiotic segregation 1 isoform c 
PMS1                  0.072   postmeiotic segregation 1 isoform a 
PMS1                  0.065   postmeiotic segregation 1 isoform b 
MLH3                  0.058   mutL homolog 3 isoform 1 
MLH3                  0.058   mutL homolog 3 isoform 2 
LOC100288713          0.050   PREDICTED: hypothetical protein XP_002342778 
LOC730323             0.050   PREDICTED: similar to Postmeiotic segregation incre...
C11orf30              0.008   EMSY protein 
AMBRA1                0.007   activating molecule in beclin-1-regulated autophagy ...
HCFC2                 0.007   host cell factor C2 
RP1                   0.007   retinitis pigmentosa RP1 protein 
WDR76                 0.007   WD repeat domain 76 
ATF2                  0.006   activating transcription factor 2 
GON4L                 0.005   gon-4-like isoform a 
C1orf106              0.005   hypothetical protein LOC55765 isoform 2 
C1orf106              0.005   hypothetical protein LOC55765 isoform 1 
NBPF20                0.005   hypothetical protein LOC400818 
NASP                  0.005   nuclear autoantigenic sperm protein isoform 2 
NASP                  0.005   nuclear autoantigenic sperm protein isoform 1 
BRD3                  0.005   bromodomain containing protein 3 
GON4L                 0.005   gon-4-like isoform b 
KIF3C                 0.005   kinesin family member 3C 
SRRM2                 0.005   splicing coactivator subunit SRm300 
AFF1                  0.005   myeloid/lymphoid or mixed-lineage leukemia trithorax ...
NBPF7                 0.005   hypothetical protein LOC343505 
PSIP1                 0.005   PC4 and SFRS1 interacting protein 1 isoform 2 [Homo...
PSIP1                 0.005   PC4 and SFRS1 interacting protein 1 isoform 1 [Homo...
PSIP1                 0.005   PC4 and SFRS1 interacting protein 1 isoform 2 
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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