Search of human proteins with 4557046

Search of human proteins with 4557046

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4557046 solute carrier family 6 member 2 [Homo sapiens]
         (617 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4557046 solute carrier family 6 member 2 [Homo sapiens]           1267   0.0  
gi|4507041 solute carrier family 6 (neurotransmitter transporter...   850   0.0  
gi|4507043 solute carrier family 6 member 4 [Homo sapiens]            622   e-178
gi|171184408 solute carrier family 6 (neurotransmitter transport...   530   e-150
gi|171184406 solute carrier family 6 (neurotransmitter transport...   530   e-150
gi|171184404 solute carrier family 6 (neurotransmitter transport...   530   e-150
gi|188528618 solute carrier family 6 (neurotransmitter transport...   529   e-150
gi|92859670 solute carrier family 6 (neurotransmitter transporte...   523   e-148
gi|197276623 solute carrier family 6 (neurotransmitter transport...   517   e-146
gi|54607094 solute carrier family 6 (neurotransmitter transporte...   517   e-146
gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo sapi...   515   e-146
gi|21361581 solute carrier family 6 (neurotransmitter transporte...   514   e-145
gi|7657587 solute carrier family 6 (neurotransmitter transporter...   513   e-145
gi|134304856 solute carrier family 6, member 7 [Homo sapiens]         513   e-145
gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo sa...   499   e-141
gi|6005715 solute carrier family 6 (amino acid transporter), mem...   483   e-136
gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo sap...   481   e-136
gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo sap...   479   e-135
gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo sap...   479   e-135
gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo sa...   414   e-115
gi|194018524 solute carrier family 6, member 18 [Homo sapiens]        354   1e-97
gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo s...   354   1e-97
gi|51468073 solute carrier family 6, member 19 [Homo sapiens]         354   1e-97
gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo s...   335   6e-92
gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo ...   288   1e-77
gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo s...   287   2e-77
gi|58219014 solute carrier family 6, member 17 [Homo sapiens]         276   5e-74
gi|55749589 solute carrier family 6, member 16 [Homo sapiens]         235   1e-61
gi|197276625 solute carrier family 6 (neurotransmitter transport...   186   7e-47
gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo s...   166   4e-41

>gi|4557046 solute carrier family 6 member 2 [Homo sapiens]
          Length = 617

 Score = 1267 bits (3279), Expect = 0.0
 Identities = 617/617 (100%), Positives = 617/617 (100%)

Query: 1   MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG 60
           MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
Sbjct: 1   MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG 60

Query: 61  KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN 120
           KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
Sbjct: 61  KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN 120

Query: 121 REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW 180
           REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
Sbjct: 121 REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW 180

Query: 181 NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC 240
           NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
Sbjct: 181 NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC 240

Query: 241 LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY 300
           LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
Sbjct: 241 LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY 300

Query: 301 RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA 360
           RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
Sbjct: 301 RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA 360

Query: 361 IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS 420
           IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
Sbjct: 361 IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS 420

Query: 421 MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS 480
           MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
Sbjct: 421 MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS 480

Query: 481 ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF 540
           ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
Sbjct: 481 ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF 540

Query: 541 KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL 600
           KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
Sbjct: 541 KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL 600

Query: 601 VAQRDIRQFQLQHWLAI 617
           VAQRDIRQFQLQHWLAI
Sbjct: 601 VAQRDIRQFQLQHWLAI 617


>gi|4507041 solute carrier family 6 (neurotransmitter transporter,
           dopamine), member 3 [Homo sapiens]
          Length = 620

 Score =  850 bits (2195), Expect = 0.0
 Identities = 416/620 (67%), Positives = 491/620 (79%), Gaps = 18/620 (2%)

Query: 6   MNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQC----LLAPRDG--DAQPRETW 59
           M+  V P       GP       K  EL++VKE+NGVQ     L  PR    +AQ RETW
Sbjct: 11  MSSVVAPAKEPNAVGP-------KEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDRETW 63

Query: 60  GKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQY 119
           GKKIDFLLSV+GFAVDLANVWRFPYLCYKNGGGAFL+PY LF++IAGMPLFYMELALGQ+
Sbjct: 64  GKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQF 123

Query: 120 NREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHT 179
           NREGAA VWKICP  KGVG+ VILI+LYVGF+YNVIIAW+L+YLFSSFT  LPW  C ++
Sbjct: 124 NREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNS 183

Query: 180 WNSPNCTD--PKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQL 237
           WNSPNC+D  P   +G   G +  +     TPAAE++ERGVLHLH+S GI D+G P+WQL
Sbjct: 184 WNSPNCSDAHPGDSSGDSSGLNDTFGT---TPAAEYFERGVLHLHQSHGIDDLGPPRWQL 240

Query: 238 LLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHI 297
             CL++V+++LYFSLWKGVKTSGKVVWITAT+PY VL  LL+ GVTLPGA +GI AYL +
Sbjct: 241 TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV 300

Query: 298 DFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVS 357
           DFYRL EA+VWIDAATQ+ FSLG GFGVLIAF+SYNKF NNCYRDA++T+SIN +TSF S
Sbjct: 301 DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS 360

Query: 358 GFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGL 417
           GF +FS LGYMA +H V I DVA +G GL+FI+YPEAI+TL  S+ WAVVFF+MLL LG+
Sbjct: 361 GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI 420

Query: 418 DSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAA 477
           DS+MGGME+VITGL D+FQ+L RHR+LFT  +  +TFLL+LFC+T GGIYV TLLD FAA
Sbjct: 421 DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA 480

Query: 478 GTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSI 537
           GTSILF VL+EAIGV+WFYGV +FS+DIQQM G RP LYWRLCWK VSP FLLFVVVVSI
Sbjct: 481 GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI 540

Query: 538 INFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENE 597
           + F+P  Y  YIFP WAN +GW IA SSM +VPIY  YKF S  GS  E+LAY I PE +
Sbjct: 541 VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD 600

Query: 598 HHLVAQRDIRQFQLQHWLAI 617
             LV + ++RQF L+HWL +
Sbjct: 601 RELVDRGEVRQFTLRHWLKV 620


>gi|4507043 solute carrier family 6 member 4 [Homo sapiens]
          Length = 630

 Score =  622 bits (1604), Expect = e-178
 Identities = 289/543 (53%), Positives = 391/543 (72%), Gaps = 9/543 (1%)

Query: 56  RETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELA 115
           RETWGKK+DFLLSV+G+AVDL NVWRFPY+CY+NGGGAFL+PYT+  I  G+PLFYMELA
Sbjct: 79  RETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELA 138

Query: 116 LGQYNREGAATVW-KICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWT 174
           LGQY+R G  ++W KICP FKG+GYA+ +IA Y+  YYN I+AW+LYYL SSFT  LPWT
Sbjct: 139 LGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWT 198

Query: 175 DCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQ 234
            C ++WN+ NCT+          ++  ++ +  +PA EFY R VL +H S G+ D+G   
Sbjct: 199 SCKNSWNTGNCTN------YFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGIS 252

Query: 235 WQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAY 294
           WQL LC+M++  V+YFS+WKGVKTSGKVVW+TAT PY +L VLLV G TLPGA  G+  Y
Sbjct: 253 WQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFY 312

Query: 295 LHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITS 354
           L  ++ +L E  VWIDAA QIFFSLG GFGVL+AFASYNKF+NNCY+DAL+TS +NC+TS
Sbjct: 313 LKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTS 372

Query: 355 FVSGFAIFSILGYMAHEHKVNIEDVATE-GAGLVFILYPEAISTLSGSTFWAVVFFVMLL 413
           FVSGF IF++LGYMA     ++ +VA + G  L+FI Y EAI+ +  STF+A++FF+ML+
Sbjct: 373 FVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLI 432

Query: 414 ALGLDSSMGGMEAVITGLADDF-QVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLL 472
            LGLDS+  G+E VIT + D+F  V  + R+ F   V  + F  +L  +T GG YV+ LL
Sbjct: 433 TLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLL 492

Query: 473 DTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFV 532
           + +A G ++L   L+EA+ VSWFYG+ +F  D+++M+GF PG +WR+CW  +SP FLLF+
Sbjct: 493 EEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFI 552

Query: 533 VVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGI 592
           +   +++   L    Y +P W+  +G+ I  SS + +P Y+ Y+ + T G+  ER+   I
Sbjct: 553 ICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSI 612

Query: 593 TPE 595
           TPE
Sbjct: 613 TPE 615


>gi|171184408 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  530 bits (1365), Expect = e-150
 Identities = 255/553 (46%), Positives = 364/553 (65%), Gaps = 11/553 (1%)

Query: 50  DGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPL 109
           +   + R  W  K++F+LSV G  + L NVWRFPYLCYKNGGGAF IPY +F  + G+P+
Sbjct: 30  EDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPV 89

Query: 110 FYMELALGQYNREGAATVW-KICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFT 168
           F++E+ALGQY  +G+ T W KICP F+G+G A ++I  Y+  YY +I+AW+L+YLFSSFT
Sbjct: 90  FFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFT 149

Query: 169 LNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIH 228
             LPWT C + WN+ +CTD   LN S  G  T +  +  +P  EF+ER VL +  +SGIH
Sbjct: 150 SELPWTTCNNFWNTEHCTD--FLNHSGAGTVTPFENFT-SPVMEFWERRVLGI--TSGIH 204

Query: 229 DIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGAS 288
           D+G  +W+L LCL++  ++ YF +WKGVK++GKVV+ TAT PY +L +LL+ GVTLPGA 
Sbjct: 205 DLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAY 264

Query: 289 NGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSS 348
            GI  YL  D +RLK+  VW+DA TQIFFS     G L A  SYNK+ NNCY+D +    
Sbjct: 265 QGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCF 324

Query: 349 INCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVF 408
           +N  TSFV+GF +FSILG+M+ E  V I +VA  G GL FI +P+A++ +  S  W+ +F
Sbjct: 325 LNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLF 384

Query: 409 FVMLLALGLDSSMGGMEAVITGLADDFQVLKR---HRKLFTFGVTFSTFLLALFCITKGG 465
           F+ML+ LGLDS    +E ++T   D F    R    R+L    +    +L+ LF +T+GG
Sbjct: 385 FIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGG 444

Query: 466 IYVLTLLDTFA-AGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFV 524
           +Y+  L D +A +G  +LF  L E + +SW YG DRF ++I+ M+G+RP    ++ W F+
Sbjct: 445 MYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFL 504

Query: 525 SPAFLLFVVVVSIINFKPLTYDD-YIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGS 583
           +P   L   + S+  + PL Y++ Y++PPW   +GW +ALSSMV VP++V+   L T+G 
Sbjct: 505 TPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGP 564

Query: 584 LWERLAYGITPEN 596
             +RL   ITP++
Sbjct: 565 FRKRLRQLITPDS 577


>gi|171184406 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  530 bits (1365), Expect = e-150
 Identities = 255/553 (46%), Positives = 364/553 (65%), Gaps = 11/553 (1%)

Query: 50  DGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPL 109
           +   + R  W  K++F+LSV G  + L NVWRFPYLCYKNGGGAF IPY +F  + G+P+
Sbjct: 30  EDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPV 89

Query: 110 FYMELALGQYNREGAATVW-KICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFT 168
           F++E+ALGQY  +G+ T W KICP F+G+G A ++I  Y+  YY +I+AW+L+YLFSSFT
Sbjct: 90  FFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFT 149

Query: 169 LNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIH 228
             LPWT C + WN+ +CTD   LN S  G  T +  +  +P  EF+ER VL +  +SGIH
Sbjct: 150 SELPWTTCNNFWNTEHCTD--FLNHSGAGTVTPFENFT-SPVMEFWERRVLGI--TSGIH 204

Query: 229 DIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGAS 288
           D+G  +W+L LCL++  ++ YF +WKGVK++GKVV+ TAT PY +L +LL+ GVTLPGA 
Sbjct: 205 DLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAY 264

Query: 289 NGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSS 348
            GI  YL  D +RLK+  VW+DA TQIFFS     G L A  SYNK+ NNCY+D +    
Sbjct: 265 QGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCF 324

Query: 349 INCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVF 408
           +N  TSFV+GF +FSILG+M+ E  V I +VA  G GL FI +P+A++ +  S  W+ +F
Sbjct: 325 LNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLF 384

Query: 409 FVMLLALGLDSSMGGMEAVITGLADDFQVLKR---HRKLFTFGVTFSTFLLALFCITKGG 465
           F+ML+ LGLDS    +E ++T   D F    R    R+L    +    +L+ LF +T+GG
Sbjct: 385 FIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGG 444

Query: 466 IYVLTLLDTFA-AGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFV 524
           +Y+  L D +A +G  +LF  L E + +SW YG DRF ++I+ M+G+RP    ++ W F+
Sbjct: 445 MYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFL 504

Query: 525 SPAFLLFVVVVSIINFKPLTYDD-YIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGS 583
           +P   L   + S+  + PL Y++ Y++PPW   +GW +ALSSMV VP++V+   L T+G 
Sbjct: 505 TPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGP 564

Query: 584 LWERLAYGITPEN 596
             +RL   ITP++
Sbjct: 565 FRKRLRQLITPDS 577


>gi|171184404 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  530 bits (1365), Expect = e-150
 Identities = 255/553 (46%), Positives = 364/553 (65%), Gaps = 11/553 (1%)

Query: 50  DGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPL 109
           +   + R  W  K++F+LSV G  + L NVWRFPYLCYKNGGGAF IPY +F  + G+P+
Sbjct: 30  EDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPV 89

Query: 110 FYMELALGQYNREGAATVW-KICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFT 168
           F++E+ALGQY  +G+ T W KICP F+G+G A ++I  Y+  YY +I+AW+L+YLFSSFT
Sbjct: 90  FFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFT 149

Query: 169 LNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIH 228
             LPWT C + WN+ +CTD   LN S  G  T +  +  +P  EF+ER VL +  +SGIH
Sbjct: 150 SELPWTTCNNFWNTEHCTD--FLNHSGAGTVTPFENFT-SPVMEFWERRVLGI--TSGIH 204

Query: 229 DIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGAS 288
           D+G  +W+L LCL++  ++ YF +WKGVK++GKVV+ TAT PY +L +LL+ GVTLPGA 
Sbjct: 205 DLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAY 264

Query: 289 NGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSS 348
            GI  YL  D +RLK+  VW+DA TQIFFS     G L A  SYNK+ NNCY+D +    
Sbjct: 265 QGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCF 324

Query: 349 INCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVF 408
           +N  TSFV+GF +FSILG+M+ E  V I +VA  G GL FI +P+A++ +  S  W+ +F
Sbjct: 325 LNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLF 384

Query: 409 FVMLLALGLDSSMGGMEAVITGLADDFQVLKR---HRKLFTFGVTFSTFLLALFCITKGG 465
           F+ML+ LGLDS    +E ++T   D F    R    R+L    +    +L+ LF +T+GG
Sbjct: 385 FIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGG 444

Query: 466 IYVLTLLDTFA-AGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFV 524
           +Y+  L D +A +G  +LF  L E + +SW YG DRF ++I+ M+G+RP    ++ W F+
Sbjct: 445 MYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFL 504

Query: 525 SPAFLLFVVVVSIINFKPLTYDD-YIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGS 583
           +P   L   + S+  + PL Y++ Y++PPW   +GW +ALSSMV VP++V+   L T+G 
Sbjct: 505 TPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGP 564

Query: 584 LWERLAYGITPEN 596
             +RL   ITP++
Sbjct: 565 FRKRLRQLITPDS 577


>gi|188528618 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 1 [Homo sapiens]
          Length = 599

 Score =  529 bits (1362), Expect = e-150
 Identities = 259/549 (47%), Positives = 357/549 (65%), Gaps = 15/549 (2%)

Query: 52  DAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFY 111
           D   R+TW  + DFL+S VG+A+ L NVWRFPYLC KNGGGAFLIPY L LI AG+PLF 
Sbjct: 40  DLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFL 99

Query: 112 MELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNL 171
           +E +LGQY   G   VWK+ P FKGVG A  +++ ++  YY VII+W++YYL++SFT  L
Sbjct: 100 LECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTL 159

Query: 172 PWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAA-EFYERGVLHLHESSGIHDI 230
           PW  C + WN+  C            N++  +    T A  EF+ER +  +  + G+   
Sbjct: 160 PWKQCDNPWNTDRC----------FSNYSMVNTTNMTSAVVEFWERNMHQM--TDGLDKP 207

Query: 231 GLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNG 290
           G  +W L + L +  I++YF +WKGV  +GKVV+ +AT PY +L +L   GVTLPGA  G
Sbjct: 208 GQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEG 267

Query: 291 INAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSIN 350
           I  Y+  +F +L ++ VW+DAATQIFFS G G G LIA  SYN F NN YRD+++   IN
Sbjct: 268 ILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCIN 327

Query: 351 CITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFV 410
             TS  +GF IFSI+G+MAH  K +I DVA  G GL F+ YPEA++ L  S  WA++FF 
Sbjct: 328 SCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFS 387

Query: 411 MLLALGLDSSMGGMEAVITGLADDF-QVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVL 469
           MLL LG+DS    +E  IT L D++ ++L+  R+LF   V   ++L+ L  IT+GGIYV 
Sbjct: 388 MLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVF 447

Query: 470 TLLDTF-AAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAF 528
            L D + A+G S+LF V  E + +SWFYGV+RF ++IQ+M+G RP ++W+LCW F +P  
Sbjct: 448 KLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPII 507

Query: 529 LLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERL 588
           +  V + S +   PLT  +Y+FP W   VGW +ALSSMVL+P Y+ Y FL+ +GSL +R+
Sbjct: 508 VAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRI 567

Query: 589 AYGITPENE 597
              + P  +
Sbjct: 568 QVMVQPSED 576


>gi|92859670 solute carrier family 6 (neurotransmitter transporter,
           glycine), member 5 [Homo sapiens]
          Length = 797

 Score =  523 bits (1347), Expect = e-148
 Identities = 250/567 (44%), Positives = 370/567 (65%), Gaps = 29/567 (5%)

Query: 56  RETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELA 115
           R  W  K+DF+LS+VG+AV L NVWRFPYL ++NGGGAFLIPY + L +AG+P+F++E++
Sbjct: 191 RGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVS 250

Query: 116 LGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTD 175
           LGQ+  +G  +VWK  P  +G G A+++I++ +  YYNVII ++L+YLF+SF   LPW  
Sbjct: 251 LGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGS 310

Query: 176 CGHTWNSPNCTDPK--LLNGSVLGNHTKY---------------SKYKFTPAA------- 211
           C + WN+P C D    LL+  V+ +H K                +   FT  A       
Sbjct: 311 CNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSG 370

Query: 212 --EFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATL 269
             E+++  VL +  S+GI   G  +W L LCL +  +++Y SL KG+KTSGKVV+ TAT 
Sbjct: 371 SEEYFKYFVLKI--SAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTATF 428

Query: 270 PYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAF 329
           PY VL +LL+ GVTLPGA  GI  ++   + +L +ATVW DAATQIFFSL A +G LI  
Sbjct: 429 PYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITL 488

Query: 330 ASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFI 389
           +SYNKF NNCYRD L+ +  N  TS  +GF IFS++G+MA+E KVNIE+VA +G G+ F+
Sbjct: 489 SSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFV 548

Query: 390 LYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDF-QVLKRHRKLFTFG 448
           +YPEA++ L  S FWA++FF+MLL LGLD+    +E ++T ++D+F + L+ H+ +FT G
Sbjct: 549 VYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLG 608

Query: 449 VTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQM 508
                F++    IT+GGIY+  L+DT+AA  +++   + E +G+S+ YG+ RF  DI+ M
Sbjct: 609 CCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMM 668

Query: 509 MGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVL 568
           +GF+P ++W++CW FV+P  L F++  S   ++P+TY  Y +P W+  +GW +   S++ 
Sbjct: 669 IGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIW 728

Query: 569 VPIYVIYKFLSTQGSLWERLAYGITPE 595
           +PI  + K     G   ERL    +P+
Sbjct: 729 IPIMFVIKMHLAPGRFIERLKLVCSPQ 755


>gi|197276623 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  517 bits (1332), Expect = e-146
 Identities = 258/563 (45%), Positives = 355/563 (63%), Gaps = 11/563 (1%)

Query: 50  DGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPL 109
           +G    RE W  KIDF+LSV G  V L NVWRFPYLCYKNGGGAFLIPY +FL  +G+P+
Sbjct: 35  EGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPV 94

Query: 110 FYMELALGQYNREGAATVW-KICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFT 168
           F++E+ +GQY  EG  T W KICP F G+GYA ++I   +  YY VI+AW+ YYLF SF 
Sbjct: 95  FFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQ 154

Query: 169 LNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFT-PAAEFYERGVLHLHESSGI 227
             LPW  C H+WN+P+C +  +     +      S   FT P  EF+ER VL L  S GI
Sbjct: 155 KELPWAHCNHSWNTPHCMEDTMRKNKSVW--ITISSTNFTSPVIEFWERNVLSL--SPGI 210

Query: 228 HDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGA 287
              G  +W L LCL++V +V +F +WKGV+++GKVV+ TAT P+ +L VLLV G+TLPGA
Sbjct: 211 DHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGA 270

Query: 288 SNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTS 347
             GI  YL+ D  RL++  VWIDA TQIFFS     G + +  SYNK+  N YRD +L  
Sbjct: 271 GAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLG 330

Query: 348 SINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVV 407
            +N  TSFVSGFAIFSILG+MA E  V+I DVA  G GL FI YP+A++ +   TFW+++
Sbjct: 331 CLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSIL 390

Query: 408 FFVMLLALGLDSSMGGMEAVITGLADDFQVLKR---HRKLFTFGVTFSTFLLALFCITKG 464
           FF+MLL LGLDS    +E  IT L D +    R    R++F   V   ++LL L  +T+G
Sbjct: 391 FFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEG 450

Query: 465 GIYVLTLLDTFAA-GTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKF 523
           G+YV  L D +AA G  +L+    E   ++W YG D   + I+ M+G+RPG + +  W  
Sbjct: 451 GMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAV 510

Query: 524 VSPAFLLFVVVVSIINFKPLTYD-DYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQG 582
           ++P   +   + S++ + PLTY+  Y++P WA  +GW +ALSSM+ VP+ ++ +   T+G
Sbjct: 511 ITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEG 570

Query: 583 SLWERLAYGITPENEHHLVAQRD 605
               R+ Y +TP   +    +R+
Sbjct: 571 PFLVRVKYLLTPREPNRWAVERE 593


>gi|54607094 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  517 bits (1332), Expect = e-146
 Identities = 258/563 (45%), Positives = 355/563 (63%), Gaps = 11/563 (1%)

Query: 50  DGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPL 109
           +G    RE W  KIDF+LSV G  V L NVWRFPYLCYKNGGGAFLIPY +FL  +G+P+
Sbjct: 35  EGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPV 94

Query: 110 FYMELALGQYNREGAATVW-KICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFT 168
           F++E+ +GQY  EG  T W KICP F G+GYA ++I   +  YY VI+AW+ YYLF SF 
Sbjct: 95  FFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQ 154

Query: 169 LNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFT-PAAEFYERGVLHLHESSGI 227
             LPW  C H+WN+P+C +  +     +      S   FT P  EF+ER VL L  S GI
Sbjct: 155 KELPWAHCNHSWNTPHCMEDTMRKNKSVW--ITISSTNFTSPVIEFWERNVLSL--SPGI 210

Query: 228 HDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGA 287
              G  +W L LCL++V +V +F +WKGV+++GKVV+ TAT P+ +L VLLV G+TLPGA
Sbjct: 211 DHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGA 270

Query: 288 SNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTS 347
             GI  YL+ D  RL++  VWIDA TQIFFS     G + +  SYNK+  N YRD +L  
Sbjct: 271 GAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLG 330

Query: 348 SINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVV 407
            +N  TSFVSGFAIFSILG+MA E  V+I DVA  G GL FI YP+A++ +   TFW+++
Sbjct: 331 CLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSIL 390

Query: 408 FFVMLLALGLDSSMGGMEAVITGLADDFQVLKR---HRKLFTFGVTFSTFLLALFCITKG 464
           FF+MLL LGLDS    +E  IT L D +    R    R++F   V   ++LL L  +T+G
Sbjct: 391 FFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEG 450

Query: 465 GIYVLTLLDTFAA-GTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKF 523
           G+YV  L D +AA G  +L+    E   ++W YG D   + I+ M+G+RPG + +  W  
Sbjct: 451 GMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAV 510

Query: 524 VSPAFLLFVVVVSIINFKPLTYD-DYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQG 582
           ++P   +   + S++ + PLTY+  Y++P WA  +GW +ALSSM+ VP+ ++ +   T+G
Sbjct: 511 ITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEG 570

Query: 583 SLWERLAYGITPENEHHLVAQRD 605
               R+ Y +TP   +    +R+
Sbjct: 571 PFLVRVKYLLTPREPNRWAVERE 593


>gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo
           sapiens]
          Length = 635

 Score =  515 bits (1326), Expect = e-146
 Identities = 252/556 (45%), Positives = 354/556 (63%), Gaps = 12/556 (2%)

Query: 55  PRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMEL 114
           PRETW +++DF++S VGFAV L NVWRFPYLCYKNGGG FLIPY L  ++ G+P+F++E+
Sbjct: 51  PRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEI 110

Query: 115 ALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWT 174
           +LGQ+ + G+  VW ICP FKG+GYA ++I  Y   YY +++AW  YYL  SFT  LPW 
Sbjct: 111 SLGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170

Query: 175 DCGHTWNSPNCTD----PKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDI 230
            CGHTWN+P+C +        N S+          + +P  EF+E  VL L  S G+   
Sbjct: 171 TCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRL--SGGLEVP 228

Query: 231 GLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNG 290
           G   W++ LCL+   +++YF +WKGVK++GK+V+ TAT PY VL VLLV GV LPGA +G
Sbjct: 229 GALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDG 288

Query: 291 INAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSIN 350
           I  YL  D+ +L    VWIDA TQIFFS   G G L A  SYN+F+NNCY+DA++ + IN
Sbjct: 289 IIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALIN 348

Query: 351 CITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFV 410
             TSF +GF +FSILG+MA E  V+I  VA  G GL FI YP A++ +  +  WA +FF 
Sbjct: 349 SGTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFF 408

Query: 411 MLLALGLDSSMGGMEAVITGLADDFQV---LKRHRKLFTFGVTFSTFLLALFCITKGGIY 467
           MLL LGLDS   G+E  ITGL D        +  R++         F++ L  +T GG+Y
Sbjct: 409 MLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMY 468

Query: 468 VLTLLDTF-AAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSP 526
           V  L D + A+GT++L+    E + V+W YG DRF +DI  M+G+RP  + + CW F +P
Sbjct: 469 VFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTP 528

Query: 527 AFLLFVVVVSIINFKPLTYDD-YIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLW 585
              + + + +++ ++PL Y++ Y++P W   +GW  ALSSM+ VP++++   L  +G++ 
Sbjct: 529 LVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMA 588

Query: 586 ERLAYGITP-ENEHHL 600
           ER  +   P    HHL
Sbjct: 589 ERWQHLTQPIWGLHHL 604


>gi|21361581 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 13 [Homo sapiens]
          Length = 602

 Score =  514 bits (1323), Expect = e-145
 Identities = 253/548 (46%), Positives = 356/548 (64%), Gaps = 12/548 (2%)

Query: 56  RETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELA 115
           R  W  K++F+LSV G  + L NVWRFPYLCYKNGGGAF IPY +FL   G+P+F +E A
Sbjct: 32  RGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLETA 91

Query: 116 LGQYNREGAATVW-KICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWT 174
           LGQY  +G  T W KICP F+G+GYA  +I + +  YY +++AW+L+YLFSSFT++LPW 
Sbjct: 92  LGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPWG 151

Query: 175 DCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQ 234
            C H WN+ +C + +  NGS+ G     S+   +P  EF+ER VL +  S GI  +G  +
Sbjct: 152 GCYHEWNTEHCMEFQKTNGSLNGT----SENATSPVIEFWERRVLKI--SDGIQHLGALR 205

Query: 235 WQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAY 294
           W+L LCL++  ++ YF +WKGVK++GKVV+ TAT PY +L VLL+ GVTLPGA+ GI  Y
Sbjct: 206 WELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFY 265

Query: 295 LHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITS 354
           L+ +  RL +  VW+DA TQIFFS     G L A  SYNK+ NNCYRD +    +N  TS
Sbjct: 266 LYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTS 325

Query: 355 FVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLA 414
           FV+GFAIFSILG+M+ E  V I +VA  G GL FI YP A+  L  S  WA  FF M++ 
Sbjct: 326 FVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVL 385

Query: 415 LGLDSSMGGMEAVITGLADDFQVL---KRHRKLFTFGVTFSTFLLALFCITKGGIYVLTL 471
           LGLDS    +E+++T L D +  +   K  R++   GV+  +FL+ L  +T+GG+YV  L
Sbjct: 386 LGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQL 445

Query: 472 LDTFAA-GTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLL 530
            D +AA G  +LF  + E++ V+W YG  RF ++I+ M+G+RP    + CW F++PA   
Sbjct: 446 FDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCT 505

Query: 531 FVVVVSIINFKPLTYD-DYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLA 589
              + S+I + PLTY+  Y +P W + +GW +ALSSMV +P + +Y+  + +G   ER+ 
Sbjct: 506 ATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRERIR 565

Query: 590 YGITPENE 597
             + P  +
Sbjct: 566 QLMCPAED 573


>gi|7657587 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 11 [Homo sapiens]
          Length = 632

 Score =  513 bits (1322), Expect = e-145
 Identities = 249/556 (44%), Positives = 359/556 (64%), Gaps = 12/556 (2%)

Query: 49  RDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMP 108
           RD     R  W  K++F+LSV G  + L NVWRFPYLCYKNGGGAFLIPY +F I  G+P
Sbjct: 43  RDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIP 102

Query: 109 LFYMELALGQYNREGAATVW-KICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSF 167
           +F++E ALGQ+  EG  T W K+CP F+G+GYA  +I  ++  YY +I+AW+++YL + F
Sbjct: 103 VFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCF 162

Query: 168 TLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFT-PAAEFYERGVLHLHESSG 226
           T  LPW  CGH WN+ NC + + LN S   N++  S    T P  EF+E  VL +  S G
Sbjct: 163 TTELPWATCGHEWNTENCVEFQKLNVS---NYSHVSLQNATSPVMEFWEHRVLAI--SDG 217

Query: 227 IHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPG 286
           I  IG  +W+L LCL+    + YF +WKG K++GKVV++TAT PY +L +LL+ GVTLPG
Sbjct: 218 IEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPG 277

Query: 287 ASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLT 346
           AS GI  YL+ D  RL +  VW+DA TQIFFS     G L A  SYN ++NNCYRD ++ 
Sbjct: 278 ASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIML 337

Query: 347 SSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAV 406
             +N  TSFV+GFAIFS+LG+MA+E  V I +VA  G GL FI YP+A++ +  S  WA 
Sbjct: 338 CCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWAT 397

Query: 407 VFFVMLLALGLDSSMGGMEAVITGLADDF-QVLKR--HRKLFTFGVTFSTFLLALFCITK 463
           +FF+ML+ LGLDS    +E+++T + D + +V +R   R+L    ++  ++ L L  +T+
Sbjct: 398 LFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTE 457

Query: 464 GGIYVLTLLDTFAA-GTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWK 522
           GG+Y+  L D++AA G  +LF  + E I + W YG +RF ++I+ M+G+RP    + CW 
Sbjct: 458 GGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWM 517

Query: 523 FVSPAFLLFVVVVSIINFKPLTYDD-YIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQ 581
            ++P     + +  +I +KPL Y++ Y +P W   +GW +ALSSM+ +P+++      T+
Sbjct: 518 IMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTE 577

Query: 582 GSLWERLAYGITPENE 597
           G+L E+L    TP  +
Sbjct: 578 GTLPEKLQKLTTPSTD 593


>gi|134304856 solute carrier family 6, member 7 [Homo sapiens]
          Length = 636

 Score =  513 bits (1322), Expect = e-145
 Identities = 255/546 (46%), Positives = 354/546 (64%), Gaps = 8/546 (1%)

Query: 53  AQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYM 112
           A  R  W  K+DFLLS +G+ V L NVWRFPY  Y NGGGAFL+PY L L I G+PLF++
Sbjct: 34  AAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFL 93

Query: 113 ELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLP 172
           EL+LGQ++  G   VWKI P FKG G A++LI   V  YYN+IIA+ L+YLF+S T +LP
Sbjct: 94  ELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLP 153

Query: 173 WTDCGHTWNSPNCTDPKLL---NGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHD 229
           W  CG+ WN+  C + ++    NG++  N T       +P+ E++ R VLH+  S GI  
Sbjct: 154 WEHCGNWWNTELCLEHRVSKDGNGALPLNLT----CTVSPSEEYWSRYVLHIQGSQGIGS 209

Query: 230 IGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASN 289
            G  +W L LCL++  ++++  + KGVK+SGKVV+ TAT PY +L +LLV GVTLPGA  
Sbjct: 210 PGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWK 269

Query: 290 GINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSI 349
           GI  YL   F+ L  + VWI+AA QIF+SLG GFG L+ FASYN F  N YRD  + +  
Sbjct: 270 GIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLG 329

Query: 350 NCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFF 409
           N ITS ++GFAIFS+LGYM+ E  V ++ VA  G GL F++YP+A++ L  S FW+ +FF
Sbjct: 330 NAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFF 389

Query: 410 VMLLALGLDSSMGGMEAVITGLADDFQVLKRHRK-LFTFGVTFSTFLLALFCITKGGIYV 468
            MLL LGLDS    +E ++T + D+F    R +K +F+  +  + +L+ L   T GG+Y 
Sbjct: 390 FMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYW 449

Query: 469 LTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAF 528
           L LLD ++A   ++  V+   + V+  YG+ RF  DI  M+GF+PGLY+R CW F+SPA 
Sbjct: 450 LVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPAT 509

Query: 529 LLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERL 588
           LL ++V SI+ ++P  Y  Y FPPWA  +G  + L S +++P  ++   L  +GSLWERL
Sbjct: 510 LLALMVYSIVKYQPSEYGSYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERL 569

Query: 589 AYGITP 594
                P
Sbjct: 570 QQASRP 575


>gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo
           sapiens]
          Length = 625

 Score =  499 bits (1285), Expect = e-141
 Identities = 248/556 (44%), Positives = 346/556 (62%), Gaps = 22/556 (3%)

Query: 55  PRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMEL 114
           PRETW +++DF++S VGFAV L NVWRFPYLCYKNGGG FLIPY L  ++ G+P+F++E+
Sbjct: 51  PRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEI 110

Query: 115 ALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWT 174
           +LGQ+ + G+  VW ICP FKG+GYA ++I  Y   YY +++AW  YYL  SFT  LPW 
Sbjct: 111 SLGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170

Query: 175 DCGHTWNSPNCTD----PKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDI 230
            CGHTWN+P+C +        N S+          + +P  EF+E  VL L  S G+   
Sbjct: 171 TCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRL--SGGLEVP 228

Query: 231 GLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNG 290
           G   W++ LCL+   +++YF +WKGVK++GK+V+ TAT PY VL VLLV GV LPGA +G
Sbjct: 229 GALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDG 288

Query: 291 INAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSIN 350
           I  YL  D+ +L    VWIDA TQIFFS   G G L A  SYN+F+NNCY          
Sbjct: 289 IIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYNG-------- 340

Query: 351 CITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFV 410
             TSF +GF +FSILG+MA E  V+I  VA  G GL FI YP A++ +  +  WA +FF 
Sbjct: 341 --TSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFF 398

Query: 411 MLLALGLDSSMGGMEAVITGLADDFQV---LKRHRKLFTFGVTFSTFLLALFCITKGGIY 467
           MLL LGLDS   G+E  ITGL D        +  R++         F++ L  +T GG+Y
Sbjct: 399 MLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMY 458

Query: 468 VLTLLDTF-AAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSP 526
           V  L D + A+GT++L+    E + V+W YG DRF +DI  M+G+RP  + + CW F +P
Sbjct: 459 VFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTP 518

Query: 527 AFLLFVVVVSIINFKPLTYDD-YIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLW 585
              + + + +++ ++PL Y++ Y++P W   +GW  ALSSM+ VP++++   L  +G++ 
Sbjct: 519 LVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMA 578

Query: 586 ERLAYGITP-ENEHHL 600
           ER  +   P    HHL
Sbjct: 579 ERWQHLTQPIWGLHHL 594


>gi|6005715 solute carrier family 6 (amino acid transporter), member
           14 [Homo sapiens]
          Length = 642

 Score =  483 bits (1243), Expect = e-136
 Identities = 242/564 (42%), Positives = 349/564 (61%), Gaps = 30/564 (5%)

Query: 54  QPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYME 113
           Q R  W KK D+LLS++G+AV L NVWRFPYL Y NGGGAFLIPY + L +AG+PLF++E
Sbjct: 34  QDRGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLE 93

Query: 114 LALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPW 173
            +LGQ+   G  +VW+I P F+GVG  ++LI+++V  YYNVIIA+SLYY+F+SF   LPW
Sbjct: 94  CSLGQFASLGPVSVWRILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASFQSELPW 153

Query: 174 TDCGHTWNSPNCTDPKLLNGSVLGNHTK--------------YSKYKFTPAAEFYERGVL 219
            +C  +W+  NC+   ++    +    K               + +     +E Y+ G L
Sbjct: 154 KNCS-SWSDKNCSRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSEIYQPGQL 212

Query: 220 ---------HLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLP 270
                     L  SSG+++ G+  W L LCL++  +++  +L+KG+K+SGKVV+ TA  P
Sbjct: 213 PSEQYWNKVALQRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFP 272

Query: 271 YFVLFVLLVHGVTLPGASNGINAYL--HIDFYRLKEATVWIDAATQIFFSLGAGFGVLIA 328
           Y VL +LLV G TL GAS GI+ Y+    +F +LKEA VW DAATQIF+SL   +G L+A
Sbjct: 273 YVVLLILLVRGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAWGGLVA 332

Query: 329 FASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVF 388
            +SYNKF NNC+ DA++    NC+TS  +GFAIFSILG+MAH     +  V   G  L F
Sbjct: 333 LSSYNKFKNNCFSDAIVVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAF 392

Query: 389 ILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDF-QVLKRHRKLFTF 447
           I YPEA++ L G  FW+++FF MLL LGLDS    +E + T + D F +V+K+ R   T 
Sbjct: 393 IAYPEALAQLPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFPKVMKKMRVPITL 452

Query: 448 GVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQ 507
           G     FLL L C+T+ GIY + L+D F AG  IL A ++E +G+ W YG +RF  D + 
Sbjct: 453 GCCLVLFLLGLVCVTQAGIYWVHLIDHFCAGWGILIAAILELVGIIWIYGGNRFIEDTEM 512

Query: 508 MMGFRP---GLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALS 564
           M+G +     L+WR CW  ++P  L+ + + S++ F    Y    +P W   +GW + + 
Sbjct: 513 MIGAKRWIFWLWWRACWFVITPILLIAIFIWSLVQFHRPNYGAIPYPDWGVALGWCMIVF 572

Query: 565 SMVLVPIYVIYKFLSTQGSLWERL 588
            ++ +PI  I K +  +G++++RL
Sbjct: 573 CIIWIPIMAIIKIIQAKGNIFQRL 596


>gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo
           sapiens]
          Length = 652

 Score =  481 bits (1238), Expect = e-136
 Identities = 244/574 (42%), Positives = 362/574 (63%), Gaps = 16/574 (2%)

Query: 38  ERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIP 97
           E+NG     A +      R  WG +I+F+L+ VG+AV L NVWRFPYLCY+NGGGAF+ P
Sbjct: 28  EQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFP 87

Query: 98  YTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIA 157
           Y + LI  G+PLF+MEL+ GQ+  +G   VW+I P FKGVGY +++++ Y+G YYNV+I 
Sbjct: 88  YFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVIC 147

Query: 158 WSLYYLFSSFTLNLPWTDCGHTWNSPNCTD----PKLLNGSV-------LGNHTKYSKYK 206
            + YY FSS T  LPW  C + WN+ +C        L NGS        L +   +S  +
Sbjct: 148 IAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQR 207

Query: 207 FTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWIT 266
            +P+ E++   VL L +  G  + G  +  LL CL V  +V++  L +GVK+SGKVV+ T
Sbjct: 208 TSPSEEYWRLYVLKLSDDIG--NFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFT 265

Query: 267 ATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVL 326
           AT PY VL +L V GVTL GA +GI  YL   + ++ EA VW DAA+QIF+SLG  +G L
Sbjct: 266 ATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGL 325

Query: 327 IAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGL 386
           I  ASYNKF NNCYRD+++ S  NC TS  +GF IFSILG+MA+   V++  VA  G GL
Sbjct: 326 ITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGL 385

Query: 387 VFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDF--QVLKRHRKL 444
            F+ YPEA++ L  S  W+++FF ML+ LGL +    +E ++T + D+   + + + +  
Sbjct: 386 AFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTY 445

Query: 445 FTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSND 504
            T GV  + FLL +   ++ GIY L L+D +AA  S++    +  + + + YG   +  D
Sbjct: 446 VTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQD 505

Query: 505 IQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALS 564
           IQ M+GF P L++++CW+FVSPA + F++V ++I ++P+TY+ Y +P WA  +G+ +ALS
Sbjct: 506 IQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALS 565

Query: 565 SMVLVPIYVIYKFLSTQG-SLWERLAYGITPENE 597
           S++ +P+Y +++   T G +L +RL     P  +
Sbjct: 566 SVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRD 599


>gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo
           sapiens]
          Length = 706

 Score =  479 bits (1234), Expect = e-135
 Identities = 244/578 (42%), Positives = 364/578 (62%), Gaps = 17/578 (2%)

Query: 34  LVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGA 93
           L + +   V      RD + + R  WG +I+F+L+ VG+AV L NVWRFPYLCY+NGGGA
Sbjct: 79  LAMAQNGAVPSEATKRDQNLK-RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGA 137

Query: 94  FLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYN 153
           F+ PY + LI  G+PLF+MEL+ GQ+  +G   VW+I P FKGVGY +++++ Y+G YYN
Sbjct: 138 FMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYN 197

Query: 154 VIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTD----PKLLNGSV-------LGNHTKY 202
           V+I  + YY FSS T  LPW  C + WN+ +C        L NGS        L +   +
Sbjct: 198 VVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNH 257

Query: 203 SKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKV 262
           S  + +P+ E++   VL L +  G  + G  +  LL CL V  +V++  L +GVK+SGKV
Sbjct: 258 SLQRTSPSEEYWRLYVLKLSDDIG--NFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKV 315

Query: 263 VWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAG 322
           V+ TAT PY VL +L V GVTL GA +GI  YL   + ++ EA VW DAA+QIF+SLG  
Sbjct: 316 VYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCA 375

Query: 323 FGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATE 382
           +G LI  ASYNKF NNCYRD+++ S  NC TS  +GF IFSILG+MA+   V++  VA  
Sbjct: 376 WGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADH 435

Query: 383 GAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDF--QVLKR 440
           G GL F+ YPEA++ L  S  W+++FF ML+ LGL +    +E ++T + D+   + + +
Sbjct: 436 GPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQ 495

Query: 441 HRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDR 500
            +   T GV  + FLL +   ++ GIY L L+D +AA  S++    +  + + + YG   
Sbjct: 496 KKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRN 555

Query: 501 FSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWG 560
           +  DIQ M+GF P L++++CW+FVSPA + F++V ++I ++P+TY+ Y +P WA  +G+ 
Sbjct: 556 YFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFL 615

Query: 561 IALSSMVLVPIYVIYKFLSTQG-SLWERLAYGITPENE 597
           +ALSS++ +P+Y +++   T G +L +RL     P  +
Sbjct: 616 MALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRD 653


>gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo
           sapiens]
          Length = 633

 Score =  479 bits (1233), Expect = e-135
 Identities = 240/556 (43%), Positives = 356/556 (64%), Gaps = 16/556 (2%)

Query: 56  RETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELA 115
           R  WG +I+F+L+ VG+AV L NVWRFPYLCY+NGGGAF+ PY + LI  G+PLF+MEL+
Sbjct: 27  RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELS 86

Query: 116 LGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTD 175
            GQ+  +G   VW+I P FKGVGY +++++ Y+G YYNV+I  + YY FSS T  LPW  
Sbjct: 87  FGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAY 146

Query: 176 CGHTWNSPNCTD----PKLLNGSV-------LGNHTKYSKYKFTPAAEFYERGVLHLHES 224
           C + WN+ +C        L NGS        L +   +S  + +P+ E++   VL L + 
Sbjct: 147 CNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDD 206

Query: 225 SGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTL 284
            G  + G  +  LL CL V  +V++  L +GVK+SGKVV+ TAT PY VL +L V GVTL
Sbjct: 207 IG--NFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTL 264

Query: 285 PGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDAL 344
            GA +GI  YL   + ++ EA VW DAA+QIF+SLG  +G LI  ASYNKF NNCYRD++
Sbjct: 265 EGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSV 324

Query: 345 LTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFW 404
           + S  NC TS  +GF IFSILG+MA+   V++  VA  G GL F+ YPEA++ L  S  W
Sbjct: 325 IISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLW 384

Query: 405 AVVFFVMLLALGLDSSMGGMEAVITGLADDF--QVLKRHRKLFTFGVTFSTFLLALFCIT 462
           +++FF ML+ LGL +    +E ++T + D+   + + + +   T GV  + FLL +   +
Sbjct: 385 SLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTS 444

Query: 463 KGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWK 522
           + GIY L L+D +AA  S++    +  + + + YG   +  DIQ M+GF P L++++CW+
Sbjct: 445 QAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWR 504

Query: 523 FVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQG 582
           FVSPA + F++V ++I ++P+TY+ Y +P WA  +G+ +ALSS++ +P+Y +++   T G
Sbjct: 505 FVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDG 564

Query: 583 -SLWERLAYGITPENE 597
            +L +RL     P  +
Sbjct: 565 DTLLQRLKNATKPSRD 580


>gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo
           sapiens]
          Length = 520

 Score =  414 bits (1063), Expect = e-115
 Identities = 210/490 (42%), Positives = 298/490 (60%), Gaps = 12/490 (2%)

Query: 121 REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW 180
           + G+  VW ICP FKG+GYA ++I  Y   YY +++AW  YYL  SFT  LPW  CGHTW
Sbjct: 2   KAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTW 61

Query: 181 NSPNCTD----PKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQ 236
           N+P+C +        N S+          + +P  EF+E  VL L  S G+   G   W+
Sbjct: 62  NTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRL--SGGLEVPGALNWE 119

Query: 237 LLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLH 296
           + LCL+   +++YF +WKGVK++GK+V+ TAT PY VL VLLV GV LPGA +GI  YL 
Sbjct: 120 VTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLK 179

Query: 297 IDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFV 356
            D+ +L    VWIDA TQIFFS   G G L A  SYN+F+NNCY+DA++ + IN  TSF 
Sbjct: 180 PDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFF 239

Query: 357 SGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALG 416
           +GF +FSILG+MA E  V+I  VA  G GL FI YP A++ +  +  WA +FF MLL LG
Sbjct: 240 AGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLG 299

Query: 417 LDSSMGGMEAVITGLADDFQV---LKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLD 473
           LDS   G+E  ITGL D        +  R++         F++ L  +T GG+YV  L D
Sbjct: 300 LDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFD 359

Query: 474 TF-AAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFV 532
            + A+GT++L+    E + V+W YG DRF +DI  M+G+RP  + + CW F +P   + +
Sbjct: 360 YYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGI 419

Query: 533 VVVSIINFKPLTYDD-YIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYG 591
            + +++ ++PL Y++ Y++P W   +GW  ALSSM+ VP++++   L  +G++ ER  + 
Sbjct: 420 FIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHL 479

Query: 592 ITP-ENEHHL 600
             P    HHL
Sbjct: 480 TQPIWGLHHL 489


>gi|194018524 solute carrier family 6, member 18 [Homo sapiens]
          Length = 628

 Score =  354 bits (909), Expect = 1e-97
 Identities = 213/604 (35%), Positives = 316/604 (52%), Gaps = 89/604 (14%)

Query: 51  GDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLF 110
           GD +P+  W  K  +LLS  GFAV L N+WRFPYLC   GGGAFLIPY + L+  G+P+F
Sbjct: 15  GDERPK--WDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIF 72

Query: 111 YMELALGQYNREGAATVWK-ICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTL 169
           ++ELA+GQ  R+G+  VW  I P+  GVG   + ++  +  YYN I+AW L+YL +SF  
Sbjct: 73  HVELAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQH 132

Query: 170 NLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHD 229
            LPW+ C           P  LN +      + S    +  + F+ R  L++  ++ I+D
Sbjct: 133 PLPWSSC-----------PPDLNRTGFVEECQGS----SAVSYFWYRQTLNI--TADIND 175

Query: 230 IGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASN 289
            G  QW LL+CL     V+Y  + +G++T+GKV++ TA  PY VL + L+ G+TLPGA+ 
Sbjct: 176 SGSIQWWLLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATK 235

Query: 290 GINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSI 349
           G+      + + L+   VW+DAATQIFFSL   FG  IAFASYN   N+C +DA++ + +
Sbjct: 236 GLIYLFTPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALV 295

Query: 350 NCITSFVSGFAIFSILGYMA---HEHKV-------------------------------- 374
           N +TS  +  A+FS+LG+ A   +EH +                                
Sbjct: 296 NRMTSLYASIAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNA 355

Query: 375 -----------------NIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGL 417
                            +  D +  G GL F+++ E    + G+  WA++FF ML  LGL
Sbjct: 356 TWPKRVAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGL 415

Query: 418 DSSMGGMEAVITGLADDFQVLKR--HRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTF 475
            +  G +EAVIT L  D  VL R   ++  T  V    FL A     + G Y L + D F
Sbjct: 416 STMFGTVEAVITPLL-DVGVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNF 474

Query: 476 AAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFL-LFVVV 534
           AA  ++L    +E +GV + YG+ RF +DI  M G RP  YWRL W+ VSP  L +FV  
Sbjct: 475 AASPNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLLTIFVAY 534

Query: 535 VSIINFKPLTY-------------DDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQ 581
           + ++ +KPL Y              + ++P WA      ++L  ++ VP+  + + L+ +
Sbjct: 535 IILLFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLTRR 594

Query: 582 GSLW 585
              W
Sbjct: 595 RRTW 598


>gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo
           sapiens]
          Length = 730

 Score =  354 bits (909), Expect = 1e-97
 Identities = 198/604 (32%), Positives = 310/604 (51%), Gaps = 107/604 (17%)

Query: 56  RETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELA 115
           R  W  K+ ++L+ VGF+V L NVWRFPYLC KNGGGA+L+PY + L++ G+PLF++EL+
Sbjct: 61  RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELS 120

Query: 116 LGQYNREGAATVWK-ICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWT 174
           +GQ  R G+  VW  I P   G+G+A  ++  +V  YYNVII WSL+Y   SF   LPW 
Sbjct: 121 VGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWD 180

Query: 175 DC------GHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIH 228
            C       HT+  P C            + T Y  Y+              L+ SS I 
Sbjct: 181 QCPLVKNASHTFVEPECEQ---------SSATTYYWYREA------------LNISSSIS 219

Query: 229 DIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGAS 288
           + G   W++ +CL+   +++  ++ KG+++SGK+++ ++  PY VL   L+    L G+ 
Sbjct: 220 ESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSI 279

Query: 289 NGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSS 348
           +GI          + E  VW +AATQ+FF+LG GFG +IAF+SYNK DNNC+ DA+L S 
Sbjct: 280 DGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSF 339

Query: 349 INCITSFVSGFAIFSILGYMAH----------------------------EHKVNIEDVA 380
           IN  TS ++   +F++LG+ A+                             H +N+  V 
Sbjct: 340 INFFTSVLATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVT 399

Query: 381 TE------------------------------------GAGLVFILYPEAISTLSGSTFW 404
            E                                    G GL FI + EA++    S FW
Sbjct: 400 AEDYHLVYDIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFW 459

Query: 405 AVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKG 464
           +V+FF+ML+ LGL S  G +E ++T + D F+V K   ++ T       F + L  + + 
Sbjct: 460 SVMFFLMLVNLGLGSMFGTIEGIVTPIVDTFKVRK---EILTVICCLLAFCIGLIFVQRS 516

Query: 465 GIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFV 524
           G Y +T+ D ++A   +L  V++E I V + YG+D+F  D++ M+GF P  Y+   WK++
Sbjct: 517 GNYFVTMFDDYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYI 576

Query: 525 SPAFLLFVVVVSIIN--FKPLTYDDYI----------FPPWANWVGWGIALSSMVLVPIY 572
           SP  LL +++ S++N    P  Y+ +I          +P W   V   + + +++ VP+ 
Sbjct: 577 SPLMLLSLLIASVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVV 636

Query: 573 VIYK 576
            I +
Sbjct: 637 FIVR 640


>gi|51468073 solute carrier family 6, member 19 [Homo sapiens]
          Length = 634

 Score =  354 bits (909), Expect = 1e-97
 Identities = 211/601 (35%), Positives = 305/601 (50%), Gaps = 96/601 (15%)

Query: 52  DAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFY 111
           +A  R  W  K  ++L+ +GF V L NVWRFPYLC  +GGGAF+IP+ + L++ G+PL Y
Sbjct: 28  EASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLY 87

Query: 112 MELALGQYNREGAATVWK-ICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLN 170
           +E A+GQ  R G+  VW  I P  KG+G A +L +  VG YYN II+W ++YLF+SF   
Sbjct: 88  LEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEP 147

Query: 171 LPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDI 230
           LPW+DC    N     D                  + +P   F+ R  L++  S+ I D 
Sbjct: 148 LPWSDCPLNENQTGYVDECA---------------RSSPVDYFWYRETLNI--STSISDS 190

Query: 231 GLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNG 290
           G  QW +LLCL     VLY    +G++T+GK V+IT+TLPY VL + L+ G+TL GA+NG
Sbjct: 191 GSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNG 250

Query: 291 INAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSIN 350
           I      +   L +   W+DA  Q+FFS    FG LI+F+SYN   NNC +D+++ S IN
Sbjct: 251 IVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIIN 310

Query: 351 CITSFVSGFAIFSILGYMA---------------------------------HEHKVNIE 377
             TS      ++S++G+ A                                  + + N  
Sbjct: 311 GFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNAS 370

Query: 378 D-------------------VATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLD 418
           D                    A EG GL FI++ EAI+ +  S  W+V+FF+ML  LGL 
Sbjct: 371 DPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLS 430

Query: 419 SSMGGMEAVITGLADDFQVL--KRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFA 476
           S  G ME V+  L  D +V+  K  +++ T  +   TFL+        G Y L+LLD++A
Sbjct: 431 SMFGNMEGVVVPL-QDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYA 489

Query: 477 AGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLL------ 530
               +L     E   V + YGVDRF+ DI+ M+G +P ++W++ W+ VSP  +L      
Sbjct: 490 GSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFF 549

Query: 531 FVVVVSIINFKPLTYDDY-------------IFPPWANWVGWGIALSSMVLVPIYVIYKF 577
           FVV VS    + LTY  +              +P W   V   +A    + +P Y IYK 
Sbjct: 550 FVVEVS----QELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKL 605

Query: 578 L 578
           +
Sbjct: 606 I 606


>gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo
           sapiens]
          Length = 592

 Score =  335 bits (860), Expect = 6e-92
 Identities = 200/571 (35%), Positives = 298/571 (52%), Gaps = 87/571 (15%)

Query: 56  RETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELA 115
           R  W   + F+ + + +AV L NVWRFPYLC   GGG+FL+PY + LI+ GMPL Y+ELA
Sbjct: 5   RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64

Query: 116 LGQYNREGAATVWK-ICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWT 174
           +GQ  R+G+   W+ I P+  GVG A ++++ ++  YYNVI AW+ +YLF SF   LPW+
Sbjct: 65  VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124

Query: 175 DCGHTWNSPNCTDPKLLNGSVLGNHTKYSKY--KFTPAAEFYERGVLHLHESSGIHDIGL 232
            C              LNG    NHT Y +   K +    F+ R  L++  S  + + G 
Sbjct: 125 VCP-------------LNG----NHTGYDEECEKASSTQYFWYRKTLNI--SPSLQENGG 165

Query: 233 PQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGIN 292
            QW+  LCL++  +V+Y  + +G +++GKVV+ TA+LPY VL + L+ G+TL GA+NG+ 
Sbjct: 166 VQWEPALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLM 225

Query: 293 AYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCI 352
                   +L     WI+AATQIFFSLG GFG LIAFASYN+  NNC + A++ S IN  
Sbjct: 226 YMFTPKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSF 285

Query: 353 TSFVSGFAIFSILGYMA---HEHKV---------------------NIEDV--------- 379
           TS  +    FSI G+ A   +E+ +                     N+E V         
Sbjct: 286 TSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYP 345

Query: 380 ---------------------ATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLD 418
                                A +G GL FI+Y EAI  +  S  W+V++F MLL LG+ 
Sbjct: 346 SKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIG 405

Query: 419 SSMGGMEAVITGLADDFQVLKRH--RKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFA 476
           S +G   A++T L D  +++  H  ++  +  V      + +    + G Y   + + +A
Sbjct: 406 SMLGNTAAILTPLTDS-KIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYA 464

Query: 477 AGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVS 536
           A  S+L  VL+E I V + YG+ RF +D++ M G     YW++ W  VSP     +++VS
Sbjct: 465 ATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSP-----LLIVS 519

Query: 537 IINFKPLTYDDYIFPPWANWVGWGIALSSMV 567
           +  F      DYI      +  W  +   +V
Sbjct: 520 LFVF---YLSDYILTGTLKYQAWDASQGQLV 547


>gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo
           sapiens]
          Length = 623

 Score =  288 bits (736), Expect = 1e-77
 Identities = 170/557 (30%), Positives = 274/557 (49%), Gaps = 107/557 (19%)

Query: 103 IIAGMPLFYMELALGQYNREGAATVWK-ICPFFKGVGYAVILIALYVGFYYNVIIAWSLY 161
           ++ G+PLF++EL++GQ  R G+  VW  I P   G+G+A  ++  +V  YYNVII WSL+
Sbjct: 1   MVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLF 60

Query: 162 YLFSSFTLNLPWTDC------GHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYE 215
           Y   SF   LPW  C       HT+  P C            + T Y  Y+         
Sbjct: 61  YFSQSFQQPLPWDQCPLVKNASHTFVEPECEQ---------SSATTYYWYREA------- 104

Query: 216 RGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLF 275
                L+ SS I + G   W++ +CL+   +++  ++ KG+++SGK+++ ++  PY VL 
Sbjct: 105 -----LNISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLI 159

Query: 276 VLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKF 335
             L+    L G+ +GI          + E  VW +AATQ+FF+LG GFG +IAF+SYNK 
Sbjct: 160 CFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKR 219

Query: 336 DNNCYRDALLTSSINCITSFVSGFAIFSILGYMAH------------------------- 370
           DNNC+ DA+L S IN  TS ++   +F++LG+ A+                         
Sbjct: 220 DNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQ 279

Query: 371 ---EHKVNIEDVATE------------------------------------GAGLVFILY 391
               H +N+  V  E                                    G GL FI +
Sbjct: 280 DIIPHHINLSTVTAEDYHLVYDIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAF 339

Query: 392 PEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTF 451
            EA++    S FW+V+FF+ML+ LGL S  G +E ++T + D F+V K   ++ T     
Sbjct: 340 TEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTFKVRK---EILTVICCL 396

Query: 452 STFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGF 511
             F + L  + + G Y +T+ D ++A   +L  V++E I V + YG+D+F  D++ M+GF
Sbjct: 397 LAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGF 456

Query: 512 RPGLYWRLCWKFVSPAFLLFVVVVSIIN--FKPLTYDDYI----------FPPWANWVGW 559
            P  Y+   WK++SP  LL +++ S++N    P  Y+ +I          +P W   V  
Sbjct: 457 APSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCV 516

Query: 560 GIALSSMVLVPIYVIYK 576
            + + +++ VP+  I +
Sbjct: 517 SLVVFAILPVPVVFIVR 533


>gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo
           sapiens]
          Length = 555

 Score =  287 bits (734), Expect = 2e-77
 Identities = 181/571 (31%), Positives = 274/571 (47%), Gaps = 124/571 (21%)

Query: 56  RETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELA 115
           R  W   + F+ + + +AV L NVWRFPYLC   GGG+FL+PY + LI+ GMPL Y+ELA
Sbjct: 5   RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELA 64

Query: 116 LGQYNREGAATVWK-ICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWT 174
           +GQ  R+G+   W+ I P+  GVG A ++++ ++  YYNVI AW+ +YLF SF   LPW+
Sbjct: 65  VGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWS 124

Query: 175 DCGHTWNSPNCTDPKLLNGSVLGNHTKYSK--YKFTPAAEFYERGVLHLHESSGIHDIGL 232
            C                  + GNHT Y +   K +    F+ R  L++  S  + + G 
Sbjct: 125 VC-----------------PLNGNHTGYDEECEKASSTQYFWYRKTLNI--SPSLQENGG 165

Query: 233 PQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGIN 292
            QW+  LCL++  +V+Y  + +G +++GK+                              
Sbjct: 166 VQWEPALCLLLAWLVVYLCILRGTESTGKI------------------------------ 195

Query: 293 AYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCI 352
                   +L     WI+AATQIFFSLG GFG LIAFASYN+  NNC + A++ S IN  
Sbjct: 196 -------EQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSF 248

Query: 353 TSFVSGFAIFSILGYMA---HEHKV---------------------NIEDV--------- 379
           TS  +    FSI G+ A   +E+ +                     N+E V         
Sbjct: 249 TSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYP 308

Query: 380 ---------------------ATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLD 418
                                A +G GL FI+Y EAI  +  S  W+V++F MLL LG+ 
Sbjct: 309 SKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIG 368

Query: 419 SSMGGMEAVITGLADDFQVLKRH--RKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFA 476
           S +G   A++T L D  +++  H  ++  +  V      + +    + G Y   + + +A
Sbjct: 369 SMLGNTAAILTPLTDS-KIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYA 427

Query: 477 AGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVS 536
           A  S+L  VL+E I V + YG+ RF +D++ M G     YW++ W  VSP     +++VS
Sbjct: 428 ATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSP-----LLIVS 482

Query: 537 IINFKPLTYDDYIFPPWANWVGWGIALSSMV 567
           +  F      DYI      +  W  +   +V
Sbjct: 483 LFVF---YLSDYILTGTLKYQAWDASQGQLV 510


>gi|58219014 solute carrier family 6, member 17 [Homo sapiens]
          Length = 727

 Score =  276 bits (705), Expect = 5e-74
 Identities = 145/343 (42%), Positives = 212/343 (61%), Gaps = 17/343 (4%)

Query: 29  KTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYK 88
           K + L V  E  G Q  +   + DA+ R  W  K+ ++L+ +GF+V L N+WRFPYLC K
Sbjct: 34  KQSVLNVAGEAGGKQKAVE-EELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQK 92

Query: 89  NGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWK-ICPFFKGVGYAVILIALY 147
           NGGGA+L+PY + LII G+PLF++ELA+GQ  R G+  VW  ICP   G+G++  ++ L+
Sbjct: 93  NGGGAYLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLF 152

Query: 148 VGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKF 207
           VG YYNVII WS++Y F SF   LPW++C           P + NGSV     +  K   
Sbjct: 153 VGLYYNVIIGWSIFYFFKSFQYPLPWSEC-----------PVVRNGSVAVVEAECEKSSA 201

Query: 208 TPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITA 267
           T    F+ R  L + +S  I + G   W++ LCL+V   ++  ++ KG+++SGKV++ ++
Sbjct: 202 T--TYFWYREALDISDS--ISESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSS 257

Query: 268 TLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLI 327
             PY VL   LV G+ L GA +GI         ++ +  VW +AATQ+FF+LG GFG +I
Sbjct: 258 LFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVI 317

Query: 328 AFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAH 370
           AF+SYNK DNNC+ DA L S IN  TS ++   +F++LG+ A+
Sbjct: 318 AFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKAN 360



 Score =  127 bits (319), Expect = 3e-29
 Identities = 72/210 (34%), Positives = 113/210 (53%), Gaps = 17/210 (8%)

Query: 378 DVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQV 437
           D + +G GL FI + EA++    S FW+V+FF+ML+ LGL S +G M  + T + D F+V
Sbjct: 432 DKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTFKV 491

Query: 438 LKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYG 497
            K   ++FT G     FL+ L  + + G Y +T+ D ++A   +   V++E I V+W YG
Sbjct: 492 PK---EMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILENIAVAWIYG 548

Query: 498 VDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF--KPLTYDDYI------ 549
             +F  ++ +M+GFRP  ++   WKFVSP  +  +   SII     P  Y  +I      
Sbjct: 549 TKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSAWIKEEAAE 608

Query: 550 ----FPPWANWVGWGIALSSMVLVPIYVIY 575
               FP WA  +   I L  +  +PI V++
Sbjct: 609 RYLYFPNWA--MALLITLIVVATLPIPVVF 636


>gi|55749589 solute carrier family 6, member 16 [Homo sapiens]
          Length = 736

 Score =  235 bits (599), Expect = 1e-61
 Identities = 173/628 (27%), Positives = 281/628 (44%), Gaps = 104/628 (16%)

Query: 25  LRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPY 84
           L  + T E + + E+   + LLA        R  W  K +++L+ VGF++  + +WRF Y
Sbjct: 80  LNQKPTHEKVQMTEKKESEVLLA--------RPFWSSKTEYILAQVGFSMKPSCLWRFAY 131

Query: 85  LCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKI-CPFFKGVGYAVIL 143
           L   +GG +F   Y   L + G+PL ++E+A GQ  R+G   VWKI  P+  GVGY+  +
Sbjct: 132 LWLNSGGCSFAAIYIFMLFLVGVPLLFLEMAAGQSMRQGGMGVWKIIAPWIGGVGYSSFM 191

Query: 144 IALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYS 203
           +   +G Y+NV+ +W ++Y+  SF   +PW  C  T NS    DP+              
Sbjct: 192 VCFILGLYFNVVNSWIIFYMSQSFQFPVPWEKCPLTMNSSGF-DPEC------------- 237

Query: 204 KYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVV 263
             + TP+  F+ +  L    S  I D G P + L+L   +   ++   +  G+K++GKV+
Sbjct: 238 -ERTTPSIYFWYQQALKA--SDRIEDGGSPVYSLVLPFFLCWCLVGAFMINGLKSTGKVI 294

Query: 264 WITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGF 323
           ++   LP F++    +  + L GA  G+   +      +   +VW  A  Q+  + G G 
Sbjct: 295 YVLVLLPCFIIVGFFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSLAGGQVLSNTGIGL 354

Query: 324 G----------------------------VLIAFASYNKF----------DNNCYRDA-- 343
           G                             L+ F S+N               C R+A  
Sbjct: 355 GSVASLASYMPQSNNCLSDAFLVSVINLLTLLVFTSFNFCVLGFWATVITHRCCERNAEI 414

Query: 344 -------------------LLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDV---AT 381
                              LL +  +   +++SG         +    + NIE     A+
Sbjct: 415 LLKLINLGKLPPDAKPPVNLLYNPTSIYNAWLSGLPQHIKSMVLREVTECNIETQFLKAS 474

Query: 382 EGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRH 441
           EG    F+ + EA+S L  S FW+ +FF+MLLA+GL S++G M+ +IT L D F   ++H
Sbjct: 475 EGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGIITPLQDTFSFFRKH 534

Query: 442 RKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRF 501
            KL   GV    F+  LF     G Y + LL  +     I+  V+ E + VSW YG  RF
Sbjct: 535 TKLLIVGVFLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIVVVVFETMAVSWAYGARRF 594

Query: 502 SNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIIN--FKPLTYDDY----------I 549
             D+  ++G      +   W  + P  LL + V  +++   KP+TY  +           
Sbjct: 595 LADLTILLGHPISPIFGWLWPHLCPVVLLIIFVTMMVHLCMKPITYMSWDSSTSKEVLRP 654

Query: 550 FPPWANWVGWGIALSSMVLVPI--YVIY 575
           +PPWA  +   I L ++V++PI  Y +Y
Sbjct: 655 YPPWALLL--MITLFAIVILPIPAYFVY 680


>gi|197276625 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform b [Homo sapiens]
          Length = 200

 Score =  186 bits (471), Expect = 7e-47
 Identities = 90/169 (53%), Positives = 110/169 (65%), Gaps = 6/169 (3%)

Query: 50  DGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPL 109
           +G    RE W  KIDF+LSV G  V L NVWRFPYLCYKNGGGAFLIPY +FL  +G+P+
Sbjct: 35  EGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPV 94

Query: 110 FYMELALGQYNREGAATVW-KICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFT 168
           F++E+ +GQY  EG  T W KICP F G+GYA ++I   +  YY VI+AW+ YYLF SF 
Sbjct: 95  FFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQ 154

Query: 169 LNLPWTDCGHTWNSPNC-TDPKLLNGSVLGNHTKYSKYKFT-PAAEFYE 215
             LPW  C H+WN+P+C  D    N SV       S   FT P  EF+E
Sbjct: 155 KELPWAHCNHSWNTPHCMEDTMRKNKSV---WITISSTNFTSPVIEFWE 200


>gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo
           sapiens]
          Length = 289

 Score =  166 bits (421), Expect = 4e-41
 Identities = 85/230 (36%), Positives = 129/230 (56%), Gaps = 31/230 (13%)

Query: 56  RETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELA 115
           R  W  K+ ++L+ VGF+V L NVWRFPYLC KNGGGA+L+PY + L++ G+PLF++EL+
Sbjct: 61  RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELS 120

Query: 116 LGQYNREGAATVWK-ICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWT 174
           +GQ  R G+  VW  I P   G+G+A  ++  +V  YYNVII WSL+Y   SF   LPW 
Sbjct: 121 VGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWD 180

Query: 175 DC------GHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIH 228
            C       HT+  P C            + T Y  Y+              L+ SS I 
Sbjct: 181 QCPLVKNASHTFVEPECEQ---------SSATTYYWYREA------------LNISSSIS 219

Query: 229 DIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLL 278
           + G   W++ +CL+   +++  ++ KG+++SGKV  +    P+ +L + +
Sbjct: 220 ESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKVSMLE---PFLILLITI 266


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.328    0.143    0.462 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,003,074
Number of Sequences: 37866
Number of extensions: 994788
Number of successful extensions: 2666
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 2514
Number of HSP's gapped (non-prelim): 44
length of query: 617
length of database: 18,247,518
effective HSP length: 108
effective length of query: 509
effective length of database: 14,157,990
effective search space: 7206416910
effective search space used: 7206416910
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.