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Search of human proteins with 4507875
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4507875 vascular cell adhesion molecule 1 isoform a
precursor [Homo sapiens]
(739 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4507875 vascular cell adhesion molecule 1 isoform a precursor... 1463 0.0
gi|18201909 vascular cell adhesion molecule 1 isoform b precurso... 704 0.0
gi|118572606 hemicentin 1 [Homo sapiens] 125 1e-28
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 121 2e-27
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 115 1e-25
gi|139948432 adlican [Homo sapiens] 112 1e-24
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 110 5e-24
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] 105 2e-22
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 103 4e-22
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 103 4e-22
gi|110349719 titin isoform N2-A [Homo sapiens] 102 1e-21
gi|157168355 CD22 molecule [Homo sapiens] 100 4e-21
gi|189571583 intercellular adhesion molecule 5 precursor [Homo s... 96 1e-19
gi|33519481 neural cell adhesion molecule 2 precursor [Homo sapi... 91 4e-18
gi|11225258 myelin associated glycoprotein isoform a precursor [... 87 7e-17
gi|18104957 myelin associated glycoprotein isoform b precursor [... 87 7e-17
gi|54607031 immunoglobulin superfamily, member 4D [Homo sapiens] 85 2e-16
gi|224994173 roundabout 1 isoform d [Homo sapiens] 84 4e-16
gi|224994171 roundabout 1 isoform c [Homo sapiens] 84 4e-16
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 84 4e-16
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 84 4e-16
gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo sapi... 82 2e-15
gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo sap... 82 2e-15
gi|19743806 roundabout 1 isoform b [Homo sapiens] 82 2e-15
gi|4506569 roundabout 1 isoform a [Homo sapiens] 82 2e-15
gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo sap... 77 4e-14
gi|13489095 sialoadhesin precursor [Homo sapiens] 77 6e-14
gi|98986445 carcinoembryonic antigen-related cell adhesion molec... 76 1e-13
gi|4827022 contactin 2 precursor [Homo sapiens] 75 3e-13
gi|7657361 contactin 6 [Homo sapiens] 73 8e-13
>gi|4507875 vascular cell adhesion molecule 1 isoform a precursor
[Homo sapiens]
Length = 739
Score = 1463 bits (3787), Expect = 0.0
Identities = 739/739 (100%), Positives = 739/739 (100%)
Query: 1 MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWR 60
MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWR
Sbjct: 1 MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWR 60
Query: 61 TQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPE 120
TQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPE
Sbjct: 61 TQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPE 120
Query: 121 IHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEV 180
IHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEV
Sbjct: 121 IHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEV 180
Query: 181 TFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGG 240
TFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGG
Sbjct: 181 TFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGG 240
Query: 241 SVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKN 300
SVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKN
Sbjct: 241 SVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKN 300
Query: 301 RKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVR 360
RKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVR
Sbjct: 301 RKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVR 360
Query: 361 SEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSS 420
SEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSS
Sbjct: 361 SEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSS 420
Query: 421 VTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKA 480
VTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKA
Sbjct: 421 VTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKA 480
Query: 481 LVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFP 540
LVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFP
Sbjct: 481 LVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFP 540
Query: 541 APKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTP 600
APKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTP
Sbjct: 541 APKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTP 600
Query: 601 KDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQL 660
KDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQL
Sbjct: 601 KDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQL 660
Query: 661 KDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLIIPAIGMIIYFA 720
KDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLIIPAIGMIIYFA
Sbjct: 661 KDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLIIPAIGMIIYFA 720
Query: 721 RKANMKGSYSLVEAQKSKV 739
RKANMKGSYSLVEAQKSKV
Sbjct: 721 RKANMKGSYSLVEAQKSKV 739
>gi|18201909 vascular cell adhesion molecule 1 isoform b precursor
[Homo sapiens]
Length = 647
Score = 704 bits (1817), Expect = 0.0
Identities = 386/549 (70%), Positives = 431/549 (78%), Gaps = 35/549 (6%)
Query: 216 ELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEG-----------LPAPEIFWSKKL-- 262
++++Y PK+ I + S L+ G +T+ CS L + S++
Sbjct: 109 QVEIYSFPKDPEIHL--SGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLE 166
Query: 263 --DNGNLQHLSGNATLTLIAMRMEDSG-IYVC---------EGVNLIGKNRKEVELIVQE 310
D +L+ S T T + +ED G + VC + V + + KE+++ +
Sbjct: 167 DADRKSLETKSLEVTFTPV---IEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISP 223
Query: 311 KPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTL 370
K + ++P ++ Q G SV +TCS G +P W ++D+ G ++ N+TLTL
Sbjct: 224 KNTVISVNPSTKL--QEGGSVTMTCSSEGLPAPEIFWSKKLDN---GNLQHLSGNATLTL 278
Query: 371 SPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSV 430
+ E+ Y+C K K +++ + +FPRDPEIEMSGGLVNGSSVTVSCKVPSV
Sbjct: 279 IAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCKVPSV 338
Query: 431 YPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHID 490
YPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHID
Sbjct: 339 YPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHID 398
Query: 491 DMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQL 550
DMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQL
Sbjct: 399 DMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQL 458
Query: 551 PNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPS 610
PNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPS
Sbjct: 459 PNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPS 518
Query: 611 ESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECES 670
ESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECES
Sbjct: 519 ESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECES 578
Query: 671 KNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLIIPAIGMIIYFARKANMKGSYS 730
KNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLIIPAIGMIIYFARKANMKGSYS
Sbjct: 579 KNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLIIPAIGMIIYFARKANMKGSYS 638
Query: 731 LVEAQKSKV 739
LVEAQKSKV
Sbjct: 639 LVEAQKSKV 647
Score = 653 bits (1684), Expect = 0.0
Identities = 381/624 (61%), Positives = 437/624 (70%), Gaps = 57/624 (9%)
Query: 1 MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWR 60
MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWR
Sbjct: 1 MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWR 60
Query: 61 TQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPE 120
TQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPE
Sbjct: 61 TQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPE 120
Query: 121 IHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEV 180
IHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEV
Sbjct: 121 IHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEV 180
Query: 181 TFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGG 240
TFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGG
Sbjct: 181 TFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGG 240
Query: 241 SVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKN 300
SVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKN
Sbjct: 241 SVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKN 300
Query: 301 RKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQID-SPLSGKV 359
RKEVELIVQ P EI + G SV ++C V PS +++ L G+
Sbjct: 301 RKEVELIVQAFPRDPEIEMSGGLVN--GSSVTVSCKV-----PSVYPLDRLEIELLKGET 353
Query: 360 RSEGTNSTLTLSPVSFEN---EHSYLCTVTCGHKKL--EKGIQVELYSF----------- 403
E S EN E +++ T+ K L + + ++ F
Sbjct: 354 ILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTL 413
Query: 404 -----PRDPEIEMSGG--LVNGSSVTVSCKVPSVYPLDRL--EIELLKGETILENIEFLE 454
PRD + +S L GSSV ++C + +P ++ +L GE L+ +
Sbjct: 414 YVNVAPRDTTVLVSPSSILEEGSSVNMTC-LSQGFPAPKILWSRQLPNGE--LQPLS--- 467
Query: 455 DTDMKSLENKSLEMTFIPT-IEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRD 513
EN +L T I T +ED+G L + + + R+ + L + V P+D
Sbjct: 468 -------ENATL--TLISTKMEDSGVYL-------CEGINQAGRSRKEVE-LIIQVTPKD 510
Query: 514 TTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMED 573
+ PS ++EG +V ++C P I+ ++ G+ S + T+ +++D
Sbjct: 511 IKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKD 570
Query: 574 SGVYLCEGINQAGRSRKEVELIIQ 597
+GVY CE N+ G + + L +Q
Sbjct: 571 AGVYECESKNKVGSQLRSLTLDVQ 594
Score = 397 bits (1020), Expect = e-110
Identities = 197/347 (56%), Positives = 257/347 (74%), Gaps = 7/347 (2%)
Query: 306 LIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTN 365
+ + F +E +P R AQIGDSV LTCS GCESP FSWRTQIDSPL+GKV +EGT
Sbjct: 18 MFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTT 77
Query: 366 STLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSC 425
STLT++PVSF NEHSYLCT TC +KLEKGIQVE+YSFP+DPEI +SG L G +TV C
Sbjct: 78 STLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKC 137
Query: 426 KVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQA 485
V VYP DRLEI+LLKG+ ++++ EFLED D KSLE KSLE+TF P IED GK LVC+A
Sbjct: 138 SVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRA 197
Query: 486 KLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKIL 545
KLHID+M+ P RQ+ + L V ++P++T + V+PS+ L+EG SV MTC S+G PAP+I
Sbjct: 198 KLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIF 257
Query: 546 WSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKL 605
WS++L NG LQ LS NATLTLI+ +MEDSG+Y+CEG+N G++RKEVELI+Q P+D ++
Sbjct: 258 WSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEI 317
Query: 606 TAFPSESVKEGDTVIISCTCGNVPETWIILKKKAE--TGDTVLKSID 650
S + G +V +SC VP + + + + E G+T+L++I+
Sbjct: 318 EM--SGGLVNGSSVTVSC---KVPSVYPLDRLEIELLKGETILENIE 359
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 125 bits (314), Expect = 1e-28
Identities = 165/680 (24%), Positives = 269/680 (39%), Gaps = 94/680 (13%)
Query: 39 IGDSVSLTCSTTGCESPFFSW---RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLC 95
+ + +SLTC +G P SW I N + G T + VS G E Y C
Sbjct: 2978 VNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGE--YTC 3035
Query: 96 TATCESRKLEKGIQVEIYSFPK----DPEIHLSGPLEAGKPITVKCSVADVYPFDRLEID 151
A ++ + +K + +Y P D E + G ++++C V P I
Sbjct: 3036 IAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPP---PVIT 3092
Query: 152 LLKGDHLMKSQEFLED-ADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTV 210
K ++ +E AD + L K EV+ D G+ VCRA +++ D
Sbjct: 3093 WYKNGRMITESTHVEILADGQMLHIKKAEVS------DTGQY-VCRA-INVAGRDDKNF- 3143
Query: 211 RQAVKELQVYI-----SPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW---SKKL 262
L VY+ P+ VI S VT+TC + G+P P I W K++
Sbjct: 3144 -----HLNVYVPPSIEGPEREVIVETISNP------VTLTCDATGIPPPTIAWLKNHKRI 3192
Query: 263 DNGN---LQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISP 319
+N + ++ LSG + L + + DSG Y C N+ GK +K L +Q P
Sbjct: 3193 ENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEI 3252
Query: 320 GPRIAAQIGDSVMLTCSVMGCESPSFSWRTQ---IDSPLSGKVRSEGTNSTLTLSPVSFE 376
++ +G++V L C+ G +P W I S + ++R STL +
Sbjct: 3253 PSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTS 3312
Query: 377 NEHSYLCTVTCGHKKLEKGIQVELYSFP----RDPEIEMSGGLVNGSSVTVSCKVPSVYP 432
+ Y C T + ++ + +Y P E E LV+ +S+ + C+ P
Sbjct: 3313 DTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVD-TSINIECRATGTPP 3371
Query: 433 LDRLEIELLKGETIL---ENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHI 489
+I LK L +I L + + + + T + +A V H
Sbjct: 3372 ---PQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGV--DNKHY 3426
Query: 490 DDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQ 549
+ F P + ++ + TVL +GSS +M C++ G PAP + W R
Sbjct: 3427 NLQVFAPPNMDN------SMGTEEITVL--------KGSSTSMACITDGTPAPSMAWLR- 3471
Query: 550 LPNGELQPLSENATLT---------LISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTP 600
+ QPL +A LT L+ + EDSG Y C N+AG K L + P
Sbjct: 3472 ----DGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPP 3527
Query: 601 KDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWIILKKKAETGDTVLKSIDGAYTIR- 656
SV + + ++C +P TW+ + D V +++ G +R
Sbjct: 3528 HINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQV-QTLGGGEVLRI 3586
Query: 657 -KAQLKDAGVYECESKNKVG 675
AQ++D G Y C + + G
Sbjct: 3587 STAQVEDTGRYTCLASSPAG 3606
Score = 124 bits (310), Expect = 4e-28
Identities = 157/694 (22%), Positives = 268/694 (38%), Gaps = 101/694 (14%)
Query: 40 GDSVSLTCSTTGCESPFFSW--RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHS--YLC 95
G V+L C +G P W + ++ S + K + S ++P G E S Y+C
Sbjct: 995 GIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSP---GGEESGEYVC 1051
Query: 96 TATCESRKLEKGIQVEIYSFPK----------DPEIHLSGPLEAGKPITVKCSVADVYPF 145
TAT + ++ +Q+ +Y P+ D + +S + AG+ +T+ C V + P
Sbjct: 1052 TATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEIS--VLAGEEVTLPCEVKSLPP- 1108
Query: 146 DRLEIDLLKGDHLMKS----QEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHI 201
I K L+ FL K ET++ D G L +
Sbjct: 1109 --PIITWAKETQLISPFSPRHTFLPSGSMKITETRT---------SDSGMYLCVATNI-- 1155
Query: 202 DEMDSVPTVRQAVKELQVYISPKNTVISVNPS-TKLQEGGSVTMTCSSEGLPAPEIFWSK 260
V QAVK L V++ PK I P K+Q G V + C+++G P P I WSK
Sbjct: 1156 -----AGNVTQAVK-LNVHVPPK---IQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSK 1206
Query: 261 ----KLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVE 316
L +G + + TL++ D+GIY C N+ G + E+ L VQE P +
Sbjct: 1207 GGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVED 1266
Query: 317 ISPGPRIAAQ---IGDSVMLTCSVMGCESPSFSWRTQIDSPLSGK-----VRSEGTNSTL 368
+ P Q + C G P+ W L+G+ + +GT L
Sbjct: 1267 LEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKW-LHNGRELTGREPGISILEDGT--LL 1323
Query: 369 TLSPVSFENEHSYLCTVT--CGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCK 426
++ V+ + Y+C G + + ++V + +D E + ++ + C
Sbjct: 1324 VIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFC- 1382
Query: 427 VPSVYPLDRLEIELLKGETIL---ENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVC 483
E+E I+ +N++ E + ++++ N + F T ED G+
Sbjct: 1383 ----------EVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCK 1432
Query: 484 QAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPK 543
+ ++ T+ P + +V+++ LE C +G P P
Sbjct: 1433 AINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALE--------CQVKGTPFPD 1484
Query: 544 ILWSRQ-----LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQV 598
I W + L + ++ L L L + + D G Y C N AG+ K+++L I +
Sbjct: 1485 IHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYI 1544
Query: 599 TPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYT---- 654
P SV + + C +P I K G ++ S Y
Sbjct: 1545 PPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYK---DGQPIMSSSQALYIDKGQ 1601
Query: 655 ---IRKAQLKDAGVYECESKNKVGSQLRSLTLDV 685
I +AQ+ D+ Y C N G+ +S +DV
Sbjct: 1602 YLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDV 1635
Score = 113 bits (283), Expect = 6e-25
Identities = 124/497 (24%), Positives = 202/497 (40%), Gaps = 53/497 (10%)
Query: 216 ELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK----LDNGNLQHLS 271
+L+VY+ P N S + + +V + C S+ +P P + W K L L
Sbjct: 2097 DLRVYVPPNIMGEEQNVSVLISQ--AVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISE 2154
Query: 272 GNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSV 331
+ L + +++D+G Y CE N+ GK K + + P ++ G+ +
Sbjct: 2155 NRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLI 2214
Query: 332 MLTCSVMGCESPSFSWRTQIDSPLS---GKVRSEGTNSTLTLSPVSFENEHSYLCTVT-- 386
L C G P+ W+ + L+ G+VR L +S + Y C +
Sbjct: 2215 SLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNV 2274
Query: 387 CGHKKLEKGIQVELYSFPRDPEIEMSGG------LVNGSSVTVSCKVPSVYPLDRLEIEL 440
G K E +QV + P I SG + G S+++ C+V + P ++
Sbjct: 2275 AGTAKKEYNLQVYIR-----PTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMK- 2328
Query: 441 LKGETILE--NIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQ 498
G +++ +E L++ + L+N + DTG+ VC A +++ M
Sbjct: 2329 -DGHPLIKAKGVEILDEGHILQLKNIH--------VSDTGR-YVCVA-VNVAGMT----- 2372
Query: 499 RQSTQTLYVNVAPRDTTVLVSPSSI-LEEGSSVNMTCLSQGFPAPKILWSRQ-----LPN 552
L V+ P SP +I + E +SV++TC + G P P I W + L N
Sbjct: 2373 -DKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSN 2431
Query: 553 GELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSES 612
++ LS L L+ T MED+G Y C N AG RK L + V P +
Sbjct: 2432 S-VRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVK 2490
Query: 613 VKEGDTVIISCTCGNVPETWIILKKKAE--TGDTVLKSIDGA--YTIRKAQLKDAGVYEC 668
VKE +V ++C P I K + D I G I Q+ G Y C
Sbjct: 2491 VKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTC 2550
Query: 669 ESKNKVGSQLRSLTLDV 685
+ + G + RS +L+V
Sbjct: 2551 LASSPAGHKSRSFSLNV 2567
Score = 112 bits (281), Expect = 9e-25
Identities = 153/665 (23%), Positives = 260/665 (39%), Gaps = 83/665 (12%)
Query: 39 IGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEH-----SY 93
+ S L C G +P +WR + L G N S L + + H Y
Sbjct: 3726 LNKSTVLECIAEGVPTPRITWRKD-GAVLAG---NHARYSILENGFLHIQSAHVTDTGRY 3781
Query: 94 LCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVA-DVYPFDRLEIDL 152
LC AT + + I ++++ P GP + V+ ++A + + I+
Sbjct: 3782 LCMATNAAGTDRRRIDLQVHV----PPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINW 3837
Query: 153 LKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQ 212
K HL+ + + L + SL V +P ++D D+ +V
Sbjct: 3838 RKNGHLLNVDQ--NQNSYRLLSSGSL-VIISPSVDDTATYECTVTNGAGDDKRTV----- 3889
Query: 213 AVKELQVYISPKNTVISVNPSTKL-QEGGSVTMTCSSEGLPAPEIFWSKK----LDNGNL 267
+L V + P I+ P+ L + +TC++ G+P P I W+K L G+
Sbjct: 3890 ---DLTVQVPPS---IADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDG 3943
Query: 268 QHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGP-RIAAQ 326
+ + + ++A ++ +G Y C N G + V L V E P I P P +
Sbjct: 3944 YRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPV---IQPQPSELHVI 4000
Query: 327 IGDSVMLTCSVMGCESPSFSWRTQ-IDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTV 385
+ + ++L C G SP +W+ + I+ SG+ + + L +S E+ +Y+C
Sbjct: 4001 LNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVA 4060
Query: 386 T----CGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELL 441
K++ +QV P E ++ +T+SC+ + P D +
Sbjct: 4061 QNPAGTALGKIKLNVQVPPVISPHLKEYVIAVD----KPITLSCEADGLPPPDITWHK-- 4114
Query: 442 KGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQS 501
G I+E+I + L + SL++ F+ D G H M S
Sbjct: 4115 DGRAIVESIR------QRVLSSGSLQIAFVQP-GDAG---------HYTCMAANVAGSSS 4158
Query: 502 TQT-LYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQ-------LPNG 553
T T L V+V PR + + E S + C++ G P P I W + L
Sbjct: 4159 TSTKLTVHVPPRIRST--EGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKY 4216
Query: 554 ELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSE-S 612
+P E L L + +EDSG Y C N AG V L + V P T P + S
Sbjct: 4217 TAEPYGE---LILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLP---TFTELPGDVS 4270
Query: 613 VKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDG--AYTIRKAQLKDAGVYECES 670
+ +G+ + +SC +P + S++G I + +D+G Y C +
Sbjct: 4271 LNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTA 4330
Query: 671 KNKVG 675
+N VG
Sbjct: 4331 ENSVG 4335
Score = 112 bits (279), Expect = 2e-24
Identities = 166/737 (22%), Positives = 279/737 (37%), Gaps = 102/737 (13%)
Query: 5 MVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQ-- 62
MV G S+ + + K+ P+++ G VS+ CS TG P +W
Sbjct: 592 MVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTG-GSEVSIMCSATGYPKPKIAWTVNDM 650
Query: 63 -IDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEI 121
I ++T++GT P G Y C A+ + ++ + PK +
Sbjct: 651 FIVGSHRYRMTSDGTLFIKNAAPKDAG---IYGCLASNSAGTDKQNSTLRYIEAPKLMVV 707
Query: 122 HLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVT 181
+ G ++C + + P ++ KGD ++ FL
Sbjct: 708 QSELLVALGDITVMECKTSGIPP---PQVKWFKGDLELRPSTFL---------------- 748
Query: 182 FTPVIEDIGKVLVCRAKLHIDEMD----SVPTVRQAVKELQVYISPKNTVISVNPSTKLQ 237
+I+ + +L + +D D ++ +A ++ + + I ++
Sbjct: 749 ---IIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSME 805
Query: 238 EGGSVTMTCSSEGLPAPEIFWSKKLDN----------GNLQHLSGNATLTLIAMRMEDSG 287
G +VT+ C +G P P I W ++LDN ++ L A L ++ + D G
Sbjct: 806 IGSNVTLPCYVQGYPEPTIKW-RRLDNMPIFSRPFSVSSISQLRTGA-LFILNLWASDKG 863
Query: 288 IYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQI-GDSVMLTCSVM-GCESPSF 345
Y+CE N GK + E + V + I P +A I G + L C+++ G P
Sbjct: 864 TYICEAENQFGKIQSETTVTVTGLVAPL-IGISPSVANVIEGQQLTLPCTLLAGNPIPER 922
Query: 346 SWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPR 405
W L + ++ +L + V ++ Y C + K V ++ P
Sbjct: 923 RWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPT 982
Query: 406 DPEIEMSGGLVNGSSVTVSCKV-----PSVYPLDRLEIELLKGETI-LENIEFLEDTDMK 459
+ + G VT+ CK PSV I KGE I + +F D
Sbjct: 983 IQHGQQILSTIEGIPVTLPCKASGNPKPSV-------IWSKKGELISTSSAKFSAGAD-- 1033
Query: 460 SLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPR------- 512
SL + P E++G+ VC A + + ++ Q T V V PR
Sbjct: 1034 ----GSLYVVS-PGGEESGE-YVCTAT---NTAGYAKRKVQLT----VYVRPRVFGDQRG 1080
Query: 513 ---DTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQL----PNGELQPLSENATLT 565
D V +S + G V + C + P P I W+++ P + ++
Sbjct: 1081 LSQDKPVEISVLA----GEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMK 1136
Query: 566 LISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSE-SVKEGDTVIISCT 624
+ T+ DSG+YLC N AG + V+L + V PK + P V+ G V I C
Sbjct: 1137 ITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPK---IQRGPKHLKVQVGQRVDIPCN 1193
Query: 625 CGNVPETWIILKKKAET----GDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRS 680
P I K T G+ + + DG +I +A DAG+Y C + N G+
Sbjct: 1194 AQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETE 1253
Query: 681 LTLDVQGRENNKDYFSP 697
+TL VQ +D P
Sbjct: 1254 ITLHVQEPPTVEDLEPP 1270
Score = 110 bits (276), Expect = 4e-24
Identities = 153/672 (22%), Positives = 264/672 (39%), Gaps = 70/672 (10%)
Query: 40 GDSVSLTCSTTGCESPFFSW-RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTAT 98
G S S+ C T G +P +W R L+ +T L + + Y C A+
Sbjct: 3450 GSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIAS 3509
Query: 99 CESRKLEKGIQVEIYSFP--KDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGD 156
E+ ++ K +++ P E H + P+ + C +A P ++
Sbjct: 3510 NEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTC-IASGIPAPKMT------- 3561
Query: 157 HLMKSQEFLEDADR-KSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVK 215
MK L D+ ++L + T +ED G+ C A + D VR
Sbjct: 3562 -WMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRY-TCLASSPAGDDDKEYLVR---- 3615
Query: 216 ELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGN-------LQ 268
V++ P + VT+ C S+ +P P I W L NG ++
Sbjct: 3616 ---VHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITW---LRNGERLQATPRVR 3669
Query: 269 HLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPR-IAAQI 327
LSG L + + D+ Y C N+ GK +E L V P I GP+ + +
Sbjct: 3670 ILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPP---NIKGGPQSLVILL 3726
Query: 328 GDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVR-SEGTNSTLTLSPVSFENEHSYLCTVT 386
S +L C G +P +WR R S N L + + YLC T
Sbjct: 3727 NKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMAT 3786
Query: 387 CGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETI 446
+ I ++++ P + ++ T++C+ + + I K +
Sbjct: 3787 NAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGI---PKPSINWRKNGHL 3843
Query: 447 LENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLY 506
L N++ +++ + L + SL + P+++DT DD + T L
Sbjct: 3844 L-NVDQNQNS-YRLLSSGSL-VIISPSVDDTATYECTVTNGAGDD--------KRTVDLT 3892
Query: 507 VNVAPRDTTVLVSPSSIL-EEGSSVNMTCLSQGFPAPKILWS----RQLPNGELQPLSEN 561
V V P ++ P+ L + + +TC + G P P I W+ R LP G+ + +
Sbjct: 3893 VQVPP---SIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSS 3949
Query: 562 ATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSE-SVKEGDTVI 620
+ +++T++ +G Y C N AG + + V L + P + PSE V + ++
Sbjct: 3950 GAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPP---VIQPQPSELHVILNNPIL 4006
Query: 621 ISCTCGNVPETWIILKKKAETGDT------VLKSIDGAYTIRKAQLKDAGVYECESKNKV 674
+ C P +I +K+ +T VL S G I +A +DAG Y C ++N
Sbjct: 4007 LPCEATGTPSPFITWQKEGINVNTSGRNHAVLPS--GGLQISRAVREDAGTYMCVAQNPA 4064
Query: 675 GSQLRSLTLDVQ 686
G+ L + L+VQ
Sbjct: 4065 GTALGKIKLNVQ 4076
Score = 108 bits (271), Expect = 1e-23
Identities = 146/691 (21%), Positives = 257/691 (37%), Gaps = 99/691 (14%)
Query: 39 IGDSVSLTCSTTGCESPFFSWRTQ---IDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLC 95
+G++V L C+ G +P W I S ++ STL + + Y C
Sbjct: 3260 LGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTC 3319
Query: 96 TATCESRKLEKGIQVEIYSFP-----KDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEI 150
AT + + ++ + +Y P KD L ++ I ++C P +I
Sbjct: 3320 VATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTS--INIECRATGTPP---PQI 3374
Query: 151 DLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTV 210
+ LK + + R + + + V + V + +D
Sbjct: 3375 NWLKNGLPLPLSSHI----RLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHY---- 3426
Query: 211 RQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHL 270
LQV+ P + +G S +M C ++G PAP + W L +G L
Sbjct: 3427 -----NLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAW---LRDGQPLGL 3478
Query: 271 SGNAT-------LTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRI 323
+ T L L+ EDSG Y C N G+ K L V E P I
Sbjct: 3479 DAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEI 3538
Query: 324 AAQIGDSVMLTCSVMGCESPSFSW-RTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYL 382
+ + + + LTC G +P +W + P + +V++ G L +S E+ Y
Sbjct: 3539 SVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYT 3598
Query: 383 CTVTCGHKKLEKGIQVELYSFPR----DPEIEMSGGLVNGSSVTVSCKVPSVYPL----- 433
C + +K V ++ P D +++ ++ VT+ CK +V P
Sbjct: 3599 CLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDIT--VLRNRQVTLECKSDAVPPPVITWL 3656
Query: 434 ---DRLE----IELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAK 486
+RL+ + +L G L+ + + D+ N + + I GK +
Sbjct: 3657 RNGERLQATPRVRILSGGRYLQ----INNADLGDTANYTCVASNI-----AGKT----TR 3703
Query: 487 LHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILW 546
I + P + P+ +L++ S++LE C+++G P P+I W
Sbjct: 3704 EFILTVNVPPN---------IKGGPQSLVILLNKSTVLE--------CIAEGVPTPRITW 3746
Query: 547 SRQ----LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKD 602
+ N + EN L + S + D+G YLC N AG R+ ++L + V P
Sbjct: 3747 RKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPP-- 3804
Query: 603 IKLTAFPSE-SVKEGDTVIISCTCGNVPETWIILKKKA------ETGDTVLKSIDGAYTI 655
+ P+ +V ++C +P+ I +K + ++ G+ I
Sbjct: 3805 -SIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVI 3863
Query: 656 RKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 686
+ D YEC N G R++ L VQ
Sbjct: 3864 ISPSVDDTATYECTVTNGAGDDKRTVDLTVQ 3894
Score = 107 bits (266), Expect = 5e-23
Identities = 139/687 (20%), Positives = 264/687 (38%), Gaps = 82/687 (11%)
Query: 38 QIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGN-----EHS 92
+IG +V+L C G P WR + P+ + + + S L + N + +
Sbjct: 805 EIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGT 864
Query: 93 YLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLE---AGKPITVKCSVADVYPFDRLE 149
Y+C A + K++ V + P I +S + G+ +T+ C++ P E
Sbjct: 865 YICEAENQFGKIQSETTVTVTGLVA-PLIGISPSVANVIEGQQLTLPCTLLAGNPIP--E 921
Query: 150 IDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPT 209
+K ++ ++ SL + ++ ++D G+ C A +V
Sbjct: 922 RRWIKNSAMLLQNPYITVRSDGSLHIERVQ------LQDGGEY-TCVAS-------NVAG 967
Query: 210 VRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK---LDNGN 266
+ V++ P T+ EG VT+ C + G P P + WSKK + +
Sbjct: 968 TNNKTTSVVVHVLP--TIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSS 1025
Query: 267 LQHLSG-NATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPG----- 320
+ +G + +L +++ E+SG YVC N G +++V+L V +P G
Sbjct: 1026 AKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDK 1085
Query: 321 -PRIAAQIGDSVMLTCSVMGCESPSFSW--RTQIDSPLSGKVRSEGTNSTLTLSPVSFEN 377
I+ G+ V L C V P +W TQ+ SP S + + + ++ ++ +
Sbjct: 1086 PVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPR-HTFLPSGSMKITETRTSD 1144
Query: 378 EHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRL- 436
YLC T + + +++ ++ P+ + G V + C PL +
Sbjct: 1145 SGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGT-PLPVIT 1203
Query: 437 -----EIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDD 491
L+ GE + N + D + + + I T + + LH+ +
Sbjct: 1204 WSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDET---EITLHVQE 1260
Query: 492 ----MEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILW- 546
+ EP + Q N + C ++G P P I W
Sbjct: 1261 PPTVEDLEPPYNTTFQERVAN-------------------QRIEFPCPAKGTPKPTIKWL 1301
Query: 547 --SRQLPNGE--LQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKD 602
R+L E + L + L + S D+G Y+C +N+AG + ++ L + V P
Sbjct: 1302 HNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVI 1361
Query: 603 IKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKK--AETGDTVLKSIDGAYTIR--KA 658
+ SV + C P I+ K T + +++++ ++ +A
Sbjct: 1362 KDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRA 1421
Query: 659 QLKDAGVYECESKNKVGSQLRSLTLDV 685
+DAG Y C++ N G+ + +DV
Sbjct: 1422 TPEDAGRYSCKAINIAGTSQKYFNIDV 1448
Score = 107 bits (266), Expect = 5e-23
Identities = 132/505 (26%), Positives = 209/505 (41%), Gaps = 89/505 (17%)
Query: 223 PKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK----LDNGNLQHLSGNATLTL 278
P+ + VN S ++ C S G PAP W K L++ + + LS L +
Sbjct: 2879 PEEVTVLVNKSALIE--------CLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQI 2930
Query: 279 IAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPR---IAAQIGDSVMLTC 335
+ ++ D G YVC N G +K L V P + GP+ + + + + LTC
Sbjct: 2931 LNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVI----GPKSENLTVVVNNFISLTC 2986
Query: 336 SVMGCESPSFSWRTQIDSPLSGKVRS----EGTNSTLTLSPVSFENEHSYLCTVTCGHKK 391
V G P SW + P+ + G + + VS E++ + G K
Sbjct: 2987 EVSGFPPPDLSWLKN-EQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESK 3045
Query: 392 LEKGIQVELYSFPRDPEIEMSGGLVN---GSSVTVSCKVPSVYPLDRLEIELLKGETILE 448
+ + V + +D + E S +VN G+SV++ C+ +V P + G I E
Sbjct: 3046 KKFSLTVYVPPSIKDHDSE-SLSVVNVREGTSVSLECESNAVPP--PVITWYKNGRMITE 3102
Query: 449 N--IEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLY 506
+ +E L D M ++ + DTG+ VC+A
Sbjct: 3103 STHVEILADGQMLHIKKAE--------VSDTGQ-YVCRA--------------------- 3132
Query: 507 VNVAPRDT-----TVLVSPSS-------ILEEGSS-VNMTCLSQGFPAPKILW---SRQL 550
+NVA RD V V PS I+E S+ V +TC + G P P I W +++
Sbjct: 3133 INVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRI 3192
Query: 551 PNG---ELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTA 607
N E++ LS + L + ++ DSG Y C N G+++K L IQV P +
Sbjct: 3193 ENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQV-PPSVAGAE 3251
Query: 608 FPSE-SVKEGDTVIISCTCGNVPE---TWIILKKKAETGDT--VLKSIDGA-YTIRKAQL 660
PS+ SV G+ V + C +P W+ K +G+T + S +G+ I A
Sbjct: 3252 IPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALT 3311
Query: 661 KDAGVYECESKNKVGSQLRSLTLDV 685
D G Y C + N G + R L+V
Sbjct: 3312 SDTGKYTCVATNPAGEEDRIFNLNV 3336
Score = 104 bits (260), Expect = 3e-22
Identities = 154/705 (21%), Positives = 271/705 (38%), Gaps = 118/705 (16%)
Query: 33 SRYLAQIGDSVSLTCSTTGCESPFFSWRTQ---IDSPLNGKVTNEGTTSTLTMNPVSFGN 89
S ++ + + + L C TG P W ID K+ G + VS N
Sbjct: 1742 SYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVS--N 1799
Query: 90 EHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLE----AGKPITVKCS------- 138
Y C A + +K +V ++ P I SG E KP+ ++C
Sbjct: 1800 TGLYRCMAANTAGDHKKEFEVTVH---VPPTIKSSGLSERVVVKYKPVALQCIANGIPNP 1856
Query: 139 ----VADVYPFDRLEIDL---LKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGK 191
+ D P + + +L G L ++ LEDA R +T V +
Sbjct: 1857 SITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGR-----------YTCVATNAAG 1905
Query: 192 VLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGL 251
+LH+ E P++ A K L TV+ NP V + C + G
Sbjct: 1906 ETQQHIQLHVHE---PPSLEDAGKML------NETVLVSNP---------VQLECKAAGN 1947
Query: 252 PAPEIFWSKKLDNGNLQHLSGNATLTLI---------AMRMEDSGIYVCEGVNLIGKNRK 302
P P I W K DN + LSG+ ++T + + ++ D+GIY C +N G
Sbjct: 1948 PVPVITWYK--DN---RLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATEL 2002
Query: 303 EVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSG----- 357
L V P +A + + V L C G +PS +W + SP+S
Sbjct: 2003 FYSLQVHVAPSI--SGSNNMVAVVVNNPVRLECEARGIPAPSLTW-LKDGSPVSSFSNGL 2059
Query: 358 KVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVN 417
+V S G LT + +S ++ + G K ++ I + +Y P E + ++
Sbjct: 2060 QVLSGGRILALTSAQISDTGRYTCVAVNAAGEK--QRDIDLRVYVPPNIMGEEQNVSVLI 2117
Query: 418 GSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDT 477
+V + C+ ++ P ++ + L+ + EN+S+ ++DT
Sbjct: 2118 SQAVELLCQSDAIPPPTLTWLK--------DGHPLLKKPGLSISENRSVLKIEDAQVQDT 2169
Query: 478 GKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQ 537
G+ C+A E K + N+ D ++ + EG+ +++ C S
Sbjct: 2170 GR-YTCEATNVAGKTE---KNYNVNIWVPPNIGGSDELTQLT----VIEGNLISLLCESS 2221
Query: 538 GFPAPKILWSRQ------LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKE 591
G P P ++W ++ G ++ LS L + + D+ +Y C N AG ++KE
Sbjct: 2222 GIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKE 2281
Query: 592 VELIIQVTPKDIKLTAFPSE-SVKEGDTVIISCTCGNVPE---TWI-----ILKKKAETG 642
L + + P + P+E V G ++ + C +P TW+ ++K K
Sbjct: 2282 YNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKG--- 2338
Query: 643 DTVLKSIDGAY--TIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 685
++ +D + ++ + D G Y C + N G + L V
Sbjct: 2339 ---VEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSV 2380
Score = 102 bits (254), Expect = 1e-21
Identities = 165/699 (23%), Positives = 263/699 (37%), Gaps = 97/699 (13%)
Query: 40 GDSVSLTCSTTGCESPFFSWRTQIDSPLN---GKVTNEGTTSTLTMNPVSFGNEHSYLCT 96
G+ +SL C ++G P W+ + L G+V L ++ + Y C
Sbjct: 2211 GNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCV 2270
Query: 97 ATCESRKLEKGIQVEIYSFPKDPEIHLSG--PLEA----GKPITVKCSVADVYPFDRLEI 150
A+ + +K +++Y P I SG P E GK I+++C V + P +
Sbjct: 2271 ASNVAGTAKKEYNLQVYI---RPTITNSGSHPTEIIVTRGKSISLECEVQGIPP---PTV 2324
Query: 151 DLLKGDHLMKSQEFLEDADRKS-LETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPT 209
+K H + + +E D L+ K++ V+ D G+ VC A +V
Sbjct: 2325 TWMKDGHPLIKAKGVEILDEGHILQLKNIHVS------DTGRY-VCVAV-------NVAG 2370
Query: 210 VRQAVKELQVYISPKNTVISVNPST-KLQEGGSVTMTCSSEGLPAPEIFWSK-----KLD 263
+ +L V+ P +P + E SV++TC + G+P P I W K L
Sbjct: 2371 MTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLS 2430
Query: 264 NGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRI 323
N +++ LSG L L+ MED+G Y C N G+ RK L V P V + +
Sbjct: 2431 N-SVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDV 2489
Query: 324 AAQIGDSVMLTCSVMGCESPSFSWRTQ---IDSPLSGKVRSEGTNSTLTLSPVSFENEHS 380
+ SV LTC V G P +W + + + S G +T V ++
Sbjct: 2490 KVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYT 2549
Query: 381 YLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPS-----VYPLDR 435
L + GHK + V + P I G N VTV P+ Y
Sbjct: 2550 CLASSPAGHKSRSFSLNVFV-----SPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPP 2604
Query: 436 LEIELLKGETILE---NIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAK------ 486
I K T LE NI L + N ED C A
Sbjct: 2605 ATITWFKDGTPLESNRNIRILPGGRTLQILNAQ---------EDNAGRYSCVATNEAGEM 2655
Query: 487 -LHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKIL 545
H + + P ++P++ + V+ + LE C + P+ +
Sbjct: 2656 IKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLE--------CEAYAIPSASLS 2707
Query: 546 W---SRQLPNGELQPLSENA-TLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPK 601
W + L + + ++ N TL + ++ D+G Y C N AG + ++ IQV P
Sbjct: 2708 WYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPS 2767
Query: 602 DIKLTAF----------PSESVKEGDTVIISCTCGNVPE---TWIILKKKAETGDTVLKS 648
KL ++ V + + + C P TW + D VL
Sbjct: 2768 FQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLIL 2827
Query: 649 IDG-AYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 686
G I +A+++DAG Y C + N+ G SL DV+
Sbjct: 2828 PGGRVLQIPRAKVEDAGRYTCVAVNEAGED--SLQYDVR 2864
Score = 101 bits (252), Expect = 2e-21
Identities = 140/638 (21%), Positives = 257/638 (40%), Gaps = 76/638 (11%)
Query: 79 TLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCS 138
+L + V F + Y C + E + + + PK + + G +++ CS
Sbjct: 575 SLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCS 634
Query: 139 VADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAK 198
A YP ++ + + F+ + R + + +D G + C A
Sbjct: 635 -ATGYPKPKIAWTV--------NDMFIVGSHRYRMTSDGTLFIKNAAPKDAG-IYGCLAS 684
Query: 199 LHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW 258
+S T +Q L+ +PK V+ L G M C + G+P P++ W
Sbjct: 685 ------NSAGTDKQN-STLRYIEAPKLMVVQSELLVAL--GDITVMECKTSGIPPPQVKW 735
Query: 259 SK-KLDNGNLQHLSGNATLTLIAMRME---DSGIYVCEGVNLIGKNRKEVELIVQEKPFT 314
K L+ L + L L+ ++ D+G Y C +N G+ ++ L V P
Sbjct: 736 FKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPP-- 793
Query: 315 VEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVS 374
V I ++ +IG +V L C V G P+ WR + P+ + S + S L +
Sbjct: 794 VFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALF 853
Query: 375 FEN-----EHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVN---GSSVTVSCK 426
N + +Y+C K++ V + P I +S + N G +T+ C
Sbjct: 854 ILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVA-PLIGISPSVANVIEGQQLTLPCT 912
Query: 427 VPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAK 486
+ + P+ E +K +L ++ SL + ++ ++D G+ +
Sbjct: 913 LLAGNPIP--ERRWIKNSAMLLQNPYITVRSDGSLHIERVQ------LQDGGEYTCVASN 964
Query: 487 LHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILW 546
+ T ++ V+V P S+I EG V + C + G P P ++W
Sbjct: 965 V--------AGTNNKTTSVVVHVLPTIQHGQQILSTI--EGIPVTLPCKASGNPKPSVIW 1014
Query: 547 SRQLPNGELQPLSE-------NATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVT 599
S++ GEL S + +L ++S E+SG Y+C N AG ++++V+L + V
Sbjct: 1015 SKK---GELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVR 1071
Query: 600 PKDIKLTAFPSE------SVKEGDTVIISCTCGNVPETWIILKKKAE------TGDTVLK 647
P+ S+ SV G+ V + C ++P I K+ + T L
Sbjct: 1072 PRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLP 1131
Query: 648 SIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 685
S G+ I + + D+G+Y C + N G+ +++ L+V
Sbjct: 1132 S--GSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNV 1167
Score = 100 bits (250), Expect = 4e-21
Identities = 141/683 (20%), Positives = 264/683 (38%), Gaps = 64/683 (9%)
Query: 39 IGDSVSLTCSTTGCESPFFSW---RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLC 95
+ SL C +W T ++S N ++ G T L + N Y C
Sbjct: 2589 LNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRT--LQILNAQEDNAGRYSC 2646
Query: 96 TATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCS-----VADVYPFDRLEI 150
AT E+ ++ K +V++Y P + L GP + K + +K + + Y +
Sbjct: 2647 VATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASL 2706
Query: 151 DLLKGDHLMKSQEFLE-DADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPT 209
K +KS + + A+ +L+ K +++ T + + +L D VP
Sbjct: 2707 SWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPP 2766
Query: 210 VRQAVKELQVYI-----SPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK--- 261
Q + E+ + VI NP +++ C + P P + W K
Sbjct: 2767 SFQKLWEIGNMLDTGRNGEAKDVIINNP---------ISLYCETNAAPPPTLTWYKDGHP 2817
Query: 262 -LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPG 320
+ + L G L + ++ED+G Y C VN G++ + ++ V P +
Sbjct: 2818 LTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSD 2877
Query: 321 --PRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSG---KVRSEGTNSTLTLSPVSF 375
+ + S ++ C G +P SW+ L K S G + + ++
Sbjct: 2878 LPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITD 2937
Query: 376 ENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDR 435
+ + T G K + V + P+ E +VN + ++++C+V P D
Sbjct: 2938 IGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVN-NFISLTCEVSGFPPPD- 2995
Query: 436 LEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFE 495
+ LK E ++ L + ++L++ I G C A +
Sbjct: 2996 --LSWLKNEQPIK----LNTNTLIVPGGRTLQI--IRAKVSDGGEYTCIAINQAGE---- 3043
Query: 496 PKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQ----LP 551
+++ + T+YV + +D + EG+SV++ C S P P I W +
Sbjct: 3044 -SKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITE 3102
Query: 552 NGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSE 611
+ ++ L++ L + ++ D+G Y+C IN AGR K L + V P + E
Sbjct: 3103 STHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPP---SIEGPERE 3159
Query: 612 SVKE--GDTVIISCTCGNVPE---TWIILKKKAETGDTV---LKSIDGAYTIRKAQLKDA 663
+ E + V ++C +P W+ K+ E D++ + S I ++Q D+
Sbjct: 3160 VIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDS 3219
Query: 664 GVYECESKNKVGSQLRSLTLDVQ 686
G Y C + N G + L +Q
Sbjct: 3220 GNYTCIASNMEGKAQKYYFLSIQ 3242
Score = 99.0 bits (245), Expect = 1e-20
Identities = 118/496 (23%), Positives = 199/496 (40%), Gaps = 49/496 (9%)
Query: 217 LQVYISPK-----NTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK----LDNGNL 267
L VY+ P + +SV ++EG SV++ C S +P P I W K ++ ++
Sbjct: 3050 LTVYVPPSIKDHDSESLSV---VNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHV 3106
Query: 268 QHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQI 327
+ L+ L + + D+G YVC +N+ G++ K L V P ++E I I
Sbjct: 3107 EILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPP-SIEGPEREVIVETI 3165
Query: 328 GDSVMLTCSVMGCESPSFSW---RTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCT 384
+ V LTC G P+ +W +I++ S +VR S L ++ + +Y C
Sbjct: 3166 SNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCI 3225
Query: 385 VTCGHKKLEKG--IQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSV-YPLDRLEIELL 441
+ K +K + +++ EI ++ G +V + C + PL I+ L
Sbjct: 3226 ASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPL----IQWL 3281
Query: 442 K-GETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQ 500
K G+ I E ++ N S + DTGK C A + + R
Sbjct: 3282 KDGKPIASG----ETERIRVSANGSTLNIYGALTSDTGK-YTCVATNPAGE-----EDRI 3331
Query: 501 STQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSE 560
+YV R L + +S+N+ C + G P P+I W L NG PLS
Sbjct: 3332 FNLNVYVTPTIRGNKDEAEKLMTLVD-TSINIECRATGTPPPQINW---LKNGLPLPLSS 3387
Query: 561 NATLT-------LISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESV 613
+ L ++ ++ D VY C N+AG K L + P +V
Sbjct: 3388 HIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITV 3447
Query: 614 KEGDTVIISCTCGNVPE---TWIILKKKAETGDTVLKSIDG-AYTIRKAQLKDAGVYECE 669
+G + ++C P W+ + + S G + KA+ +D+G Y C
Sbjct: 3448 LKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCI 3507
Query: 670 SKNKVGSQLRSLTLDV 685
+ N+ G + L V
Sbjct: 3508 ASNEAGEVSKHFILKV 3523
Score = 98.6 bits (244), Expect = 2e-20
Identities = 108/458 (23%), Positives = 188/458 (41%), Gaps = 39/458 (8%)
Query: 242 VTMTCSSEGLPAPEIFWSKK---LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIG 298
+T++C ++GLP P+I W K + Q + + +L + ++ D+G Y C N+ G
Sbjct: 4096 ITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAG 4155
Query: 299 KNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQ--IDSPLS 356
+ +L V P + + G +L C G +P+ +W+ + + L
Sbjct: 4156 SSSTSTKLTVHVPP-RIRSTEG-HYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLL 4213
Query: 357 GKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLV 416
GK +E L L V E+ Y C + + + ++ P E+ L
Sbjct: 4214 GKYTAEPYGE-LILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLN 4272
Query: 417 NGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIED 476
G + +SCK + PL +L I + + + +E S E D
Sbjct: 4273 KGEQLRLSCKATGI-PLPKLTWTF-NNNIIPAHFDSVNGHSELVIERVSKE--------D 4322
Query: 477 TGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEE-GSSVNMTCL 535
+G VC A+ + ++ + +YV P PS+ +E G + + C
Sbjct: 4323 SG-TYVCTAENSVGFVK-------AIGFVYVKEPPVFKGDY--PSNWIEPLGGNAILNCE 4372
Query: 536 SQGFPAPKILWSRQLPNGELQPLSE---NATLTLISTKMEDSGVYLCEGINQAGRSRKEV 592
+G P P I W+R+ + E+ N +L + T ED+G Y C N+AG + +
Sbjct: 4373 VKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSM 4432
Query: 593 ELIIQVTPKDIKLTAFPSESV-KEGDTVIISCTCGNVPE---TWIILKKKAETGDTVLKS 648
L +Q P +T P E+V G +I++C P+ TW D V
Sbjct: 4433 SLTLQSPP---IITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVL 4489
Query: 649 IDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 686
+ + I AQ +D +EC ++N +GS L + + VQ
Sbjct: 4490 SNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQ 4527
Score = 97.8 bits (242), Expect = 3e-20
Identities = 128/578 (22%), Positives = 210/578 (36%), Gaps = 56/578 (9%)
Query: 162 QEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYI 221
Q LED K L + I DIG+ VC A+ + V +
Sbjct: 2911 QPLLEDDHHKFLSNGRILQILNTQITDIGRY-VCVAENTAGSAKKYFNLNVHVPPSVIGP 2969
Query: 222 SPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLD----NGNLQHLSGNATLT 277
+N + VN +++TC G P P++ W K N N + G TL
Sbjct: 2970 KSENLTVVVN--------NFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQ 3021
Query: 278 LIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQI--GDSVMLTC 335
+I ++ D G Y C +N G+++K+ L V P + + G SV L C
Sbjct: 3022 IIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLEC 3081
Query: 336 SVMGCESPSFSWRTQIDSPLSGKVRSEGTN-------STLTLSPVSFENEHSYLCTVTCG 388
P +W +G++ +E T+ L + + Y+C
Sbjct: 3082 ESNAVPPPVITWYK------NGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINV 3135
Query: 389 HKKLEKGIQVELYSFP--RDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETI 446
+ +K + +Y P PE E+ ++ + VT++C + P I LK
Sbjct: 3136 AGRDDKNFHLNVYVPPSIEGPEREVIVETIS-NPVTLTCDATGIPPPT---IAWLKNHKR 3191
Query: 447 LENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLY 506
+EN + LE ++ L S D+G + + ++ Q ++
Sbjct: 3192 IENSDSLE---VRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVA 3248
Query: 507 VNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGELQPLSENA- 562
P D +VL+ G +V + C + G P P I W + + +GE + + +A
Sbjct: 3249 GAEIPSDVSVLL--------GENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSAN 3300
Query: 563 --TLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVI 620
TL + D+G Y C N AG + L + VTP + + DT I
Sbjct: 3301 GSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSI 3360
Query: 621 -ISCTCGNVPETWIILKKKAE----TGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVG 675
I C P I K + L + I +AQ+ D VY C + N+ G
Sbjct: 3361 NIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAG 3420
Query: 676 SQLRSLTLDVQGRENNKDYFSPELLVLYFASSLIIPAI 713
+ L V N + E + + SS + I
Sbjct: 3421 VDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACI 3458
Score = 95.1 bits (235), Expect = 2e-19
Identities = 138/584 (23%), Positives = 228/584 (39%), Gaps = 80/584 (13%)
Query: 39 IGDSVSLTCSTTGCESPFFSWRTQ-IDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTA 97
+ + + L C TG SPF +W+ + I+ +G+ + L ++ + +Y+C A
Sbjct: 4001 LNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVA 4060
Query: 98 TCESR----KLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLL 153
+ K++ +QV P E ++ KPIT+ C + P D I
Sbjct: 4061 QNPAGTALGKIKLNVQVPPVISPHLKEYVIA----VDKPITLSCEADGLPPPD---ITWH 4113
Query: 154 KGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQA 213
K + +E ++ L + SL++ F D G A + S
Sbjct: 4114 KD-----GRAIVESIRQRVLSSGSLQIAFVQP-GDAGHYTCMAANVAGSSSTST------ 4161
Query: 214 VKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGN 273
+L V++ P+ + S + E + C ++G+P P I W K DN L +L G
Sbjct: 4162 --KLTVHVPPR--IRSTEGHYTVNENSQAILPCVADGIPTPAINWKK--DNVLLANLLGK 4215
Query: 274 AT------LTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQI 327
T L L + +EDSG Y C N G++ V L V P E+ PG ++
Sbjct: 4216 YTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTEL-PGD-VSLNK 4273
Query: 328 GDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTC 387
G+ + L+C G P +W T ++ + S +S L + VS E+ +Y+CT
Sbjct: 4274 GEQLRLSCKATGIPLPKLTW-TFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTA-- 4330
Query: 388 GHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLE--IELLKGET 445
E S G V V K P V+ D IE L G
Sbjct: 4331 ----------------------ENSVGFVKAIGF-VYVKEPPVFKGDYPSNWIEPLGGNA 4367
Query: 446 ILENIEFLED-TDMKSLENKSLEMTFIPTIEDTGK-ALVCQAKLHIDDMEF------EPK 497
IL N E D T K +++ I G +L ++ D ++ E
Sbjct: 4368 IL-NCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAG 4426
Query: 498 QRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQ---LPNGE 554
+ + +L + P T L +++ G + + C + G P P I WSRQ + +
Sbjct: 4427 VVERSMSLTLQSPPIIT--LEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDD 4484
Query: 555 LQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQV 598
+ N +L + + ED+ + C N G V +I+QV
Sbjct: 4485 RVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQV 4528
Score = 85.5 bits (210), Expect = 2e-16
Identities = 120/527 (22%), Positives = 215/527 (40%), Gaps = 63/527 (11%)
Query: 217 LQVYISPKNTVISVNPSTKLQE-----GGSVTMTCSSEGLPAPEIFWSKK----LDNGNL 267
L V++SP T+ V ++ ++ C + P I W K N N+
Sbjct: 2565 LNVFVSP--TIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNI 2622
Query: 268 QHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVE-------ISPG 320
+ L G TL ++ + +++G Y C N G+ K E+ V P + +SP
Sbjct: 2623 RILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSP- 2681
Query: 321 PRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGK--VRSEGTNSTLTLSPVSFENE 378
+ ++ +++ L C S S SW PL V TL + +
Sbjct: 2682 KEVKIKVNNTLTLECEAYAIPSASLSWYKD-GQPLKSDDHVNIAANGHTLQIKEAQISDT 2740
Query: 379 HSYLCTVT--CGHKKLEKGIQVELY-SFPRDPEI-EMSGGLVNGSSVTVSCKVP-SVYPL 433
Y C + G +L+ + +++ SF + EI M NG + V P S+Y
Sbjct: 2741 GRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLY-- 2798
Query: 434 DRLEIELLKGETILENIEFLEDTDMKSLENKSL-----EMTFIPT--IEDTGK-ALVCQA 485
E T+ + +D + +K L + IP +ED G+ V
Sbjct: 2799 --CETNAAPPPTLT----WYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVN 2852
Query: 486 KLHIDDMEFEPKQRQSTQTLYVNV-APRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKI 544
+ D ++++ + N P + TVLV+ S+++E CLS G PAP+
Sbjct: 2853 EAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIE--------CLSSGSPAPRN 2904
Query: 545 LWSRQ----LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTP 600
W + L + + LS L +++T++ D G Y+C N AG ++K L + V P
Sbjct: 2905 SWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPP 2964
Query: 601 KDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWIILKKKAETGDTVLKSIDGAYTIR- 656
I + + +V + + ++C P +W+ ++ + L + G T++
Sbjct: 2965 SVIGPKS-ENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTL-IVPGGRTLQI 3022
Query: 657 -KAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVL 702
+A++ D G Y C + N+ G + +L V + KD+ S L V+
Sbjct: 3023 IRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVV 3069
Score = 84.3 bits (207), Expect = 4e-16
Identities = 114/529 (21%), Positives = 201/529 (37%), Gaps = 63/529 (11%)
Query: 217 LQVYISPKNTVISVNPSTKLQE----GGSVTMTCSSEGLPAPEIFWSKK----LDNGNLQ 268
+ VY+ P +I N +T L + S+T+ C + G P+P + W K N N++
Sbjct: 1633 VDVYVPP---MIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIR 1689
Query: 269 HLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIG 328
+G L +++ + D G Y+C ++ G+ + E+ V P +
Sbjct: 1690 IEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVN 1749
Query: 329 DSVMLTCSVMGCESPSFSWRTQ---IDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTV 385
+ + L C V G P+ W ID K+ G + + VS + +
Sbjct: 1750 NLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAAN 1809
Query: 386 TCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGET 445
T G K E + V + P I+ SG +S +V V + ++ +
Sbjct: 1810 TAGDHKKEFEVTVHV-----PPTIKSSG---------LSERV--VVKYKPVALQCIANGI 1853
Query: 446 ILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTL 505
+I +L+D + +L++ + K L+ A + + Q L
Sbjct: 1854 PNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQL 1913
Query: 506 YVNVAPR--------DTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILW--SRQLPNG-- 553
+V+ P + TVLVS + V + C + G P P I W +L +G
Sbjct: 1914 HVHEPPSLEDAGKMLNETVLVS--------NPVQLECKAAGNPVPVITWYKDNRLLSGST 1965
Query: 554 ELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESV 613
+ L+ + + S ++ D+G+Y C IN AG + L + V P +V
Sbjct: 1966 SMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNM--VAV 2023
Query: 614 KEGDTVIISCTCGNVPE---TWIILKKKAETGDTVLKSIDGA--YTIRKAQLKDAGVYEC 668
+ V + C +P TW+ + L+ + G + AQ+ D G Y C
Sbjct: 2024 VVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTC 2083
Query: 669 ESKNKVGSQLRSLTL------DVQGRENNKDYFSPELLVLYFASSLIIP 711
+ N G + R + L ++ G E N + + L S I P
Sbjct: 2084 VAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPP 2132
Score = 80.9 bits (198), Expect = 4e-15
Identities = 113/509 (22%), Positives = 195/509 (38%), Gaps = 47/509 (9%)
Query: 222 SPKNTVISVNPSTKLQEGGSVTMTCSSEGL-PAPEIFWSKKLDNGNLQHL--SGNATLTL 278
+PK T+ P LQ G + CS + L P F + G Q+L S + L +
Sbjct: 430 APKVTMPEKTPGYYLQPG---QIPCSVDSLLPFTLSFVRNGVTLGVDQYLKESASVNLDI 486
Query: 279 IAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVM 338
+ + D G Y C V+ G R + V E P +++ + G+ +LTC ++
Sbjct: 487 AKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVP--NNVTVTPGERAVLTCLII 544
Query: 339 GCESPSFSW-RTQIDSPLSGKVRSEG-TNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGI 396
+ +W R D L+ R N +L L V F + Y C V+ +
Sbjct: 545 SAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASV 604
Query: 397 QVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDT 456
+ + P+ + + GS V++ C YP ++ +
Sbjct: 605 FLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATG-YPKPKIAWTV---------------N 648
Query: 457 DMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTV 516
DM + + MT T+ A +Q++ Y+ AP+ +
Sbjct: 649 DMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIE-APK--LM 705
Query: 517 LVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQP---LSENATLTLI---STK 570
+V ++ G M C + G P P++ W + + EL+P L + L L+ T+
Sbjct: 706 VVQSELLVALGDITVMECKTSGIPPPQVKWFK--GDLELRPSTFLIIDPLLGLLKIQETQ 763
Query: 571 MEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE 630
D+G Y C IN+AGR+ ++ L + P I+ A S++ G V + C PE
Sbjct: 764 DLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPA--DVSMEIGSNVTLPCYVQGYPE 821
Query: 631 TWIILKK--------KAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLT 682
I ++ + + ++ + GA I D G Y CE++N+ G T
Sbjct: 822 PTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETT 881
Query: 683 LDVQGRENNKDYFSPELLVLYFASSLIIP 711
+ V G SP + + L +P
Sbjct: 882 VTVTGLVAPLIGISPSVANVIEGQQLTLP 910
Score = 76.3 bits (186), Expect = 1e-13
Identities = 141/705 (20%), Positives = 253/705 (35%), Gaps = 99/705 (14%)
Query: 26 KIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPL-NGKVTNEGTTSTLTMNP 84
KI+ P+ Q+G V + C+ G P +W + L +G+ TL+++
Sbjct: 1172 KIQRGPK-HLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQ 1230
Query: 85 VSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYP 144
+ + Y C AT + E I + + P + LE T + VA+
Sbjct: 1231 ATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVED------LEPPYNTTFQERVAN--- 1281
Query: 145 FDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEM 204
R+E + ++L + + + + +ED G +LV + +
Sbjct: 1282 -QRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISI-----LED-GTLLVIAS---VTPY 1331
Query: 205 DSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGS---------VTMTCSSEGLPAPE 255
D+ + AV E N + V P K +E + + C EG P+P
Sbjct: 1332 DNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPI 1391
Query: 256 IFWSKK----LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEK 311
I W K ++ +Q ++ L L ED+G Y C+ +N+ G ++K + V
Sbjct: 1392 IMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVP 1451
Query: 312 PFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSE--GTNSTLT 369
P + + ++ + V L C V G P W G E L
Sbjct: 1452 PTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLH 1511
Query: 370 LSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPS 429
L ++ Y CTV+ K K I++ +Y P + G +VT V
Sbjct: 1512 LKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPS----------IKGGNVTTDISV-- 1559
Query: 430 VYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHI 489
++ ++ LE E + L M I +D + L+I
Sbjct: 1560 ----------------LINSLIKLE------CETRGLPMPAITWYKDGQPIMSSSQALYI 1597
Query: 490 DDMEFE--PKQRQSTQTLY------------------VNVAPRDTTVLVSP-SSILEEGS 528
D ++ P+ + S Y V V P L +P + +
Sbjct: 1598 DKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAH 1657
Query: 529 SVNMTCLSQGFPAPKILWSRQ----LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQ 584
S+ + C + G P+P + W + N ++ + L ++S + D G Y+C +
Sbjct: 1658 SLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSV 1717
Query: 585 AGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISC-TCGNVPET--WIILKKKAET 641
AG + E+ + V P V + + + C G+ P T W+ + +
Sbjct: 1718 AGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDE 1777
Query: 642 GDTVLKSIDG-AYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 685
D ++G I +AQ+ + G+Y C + N G + + V
Sbjct: 1778 RDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTV 1822
Score = 71.6 bits (174), Expect = 2e-12
Identities = 82/376 (21%), Positives = 152/376 (40%), Gaps = 29/376 (7%)
Query: 35 YLAQIGDSVSLTCSTTGCESPFFSWRTQ---IDSPLNGKVTNEGTTSTLTMNPVSFGNEH 91
Y+ + ++L+C G P +W I + +V + G+ + P G+
Sbjct: 4088 YVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQP---GDAG 4144
Query: 92 SYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEID 151
Y C A + ++ ++ P+ + + C VAD P +
Sbjct: 4145 HYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPC-VADGIPTPAIN-- 4201
Query: 152 LLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVR 211
K D+++ + + + E + V+ED G C A E TV
Sbjct: 4202 -WKKDNVLLANLL----GKYTAEPYGELILENVVLEDSG-FYTCVANNAAGE--DTHTV- 4252
Query: 212 QAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWS--KKLDNGNLQH 269
L V++ P T + + S L +G + ++C + G+P P++ W+ + +
Sbjct: 4253 ----SLTVHVLPTFTELPGDVS--LNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDS 4306
Query: 270 LSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGD 329
++G++ L + + EDSG YVC N +G + + V+E P P I +G
Sbjct: 4307 VNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWI-EPLGG 4365
Query: 330 SVMLTCSVMGCESPSFSW-RTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCG 388
+ +L C V G +P+ W R +D +S ++R G N +L + E+ Y C T
Sbjct: 4366 NAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLG-NGSLAIYGTVNEDAGDYTCVATNE 4424
Query: 389 HKKLEKGIQVELYSFP 404
+E+ + + L S P
Sbjct: 4425 AGVVERSMSLTLQSPP 4440
Score = 61.6 bits (148), Expect = 3e-09
Identities = 75/359 (20%), Positives = 135/359 (37%), Gaps = 31/359 (8%)
Query: 32 ESRYLAQIGDSVSLTCSTTGCESPFFSWRTQ--IDSPLNGKVTNEGTTSTLTMNPVSFGN 89
E Y L C G +P +W+ + + L GK T E L + V +
Sbjct: 4175 EGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAE-PYGELILENVVLED 4233
Query: 90 EHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLE 149
Y C A + + + + ++ P E+ L G+ + + C + P +L
Sbjct: 4234 SGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGI-PLPKLT 4292
Query: 150 IDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPT 209
+ A S+ S E+ V ++ VC A+ + + ++
Sbjct: 4293 WTFNNN---------IIPAHFDSVNGHS-ELVIERVSKEDSGTYVCTAENSVGFVKAIGF 4342
Query: 210 VRQAVKELQVYIS--PKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNL 267
V VKE V+ P N + + GG+ + C +G P P I W++K + +
Sbjct: 4343 VY--VKEPPVFKGDYPSNWIEPL--------GGNAILNCEVKGDPTPTIQWNRKGVDIEI 4392
Query: 268 QHLS---GNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIA 324
H GN +L + ED+G Y C N G + + L +Q P + + P +
Sbjct: 4393 SHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPI-ITLEPVETVI 4451
Query: 325 AQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLC 383
G ++L C G P+ +W Q S + +N++L ++ E+ + C
Sbjct: 4452 -NAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFEC 4509
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 121 bits (304), Expect = 2e-27
Identities = 157/711 (22%), Positives = 271/711 (38%), Gaps = 115/711 (16%)
Query: 28 ETTPESRYLAQIGDSVSLTCSTTGCESPFF-----SWRTQIDSPLNGKVTNEGTTSTLTM 82
+ P G++ L+C G E+P+ WR S G+V S L +
Sbjct: 402 QLVPAPNVTVSPGETAVLSCRVLG-EAPYNLTWVRDWRVLPAS--TGRVAQLADLS-LEI 457
Query: 83 NPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGP-LEAGKPITVKCSVAD 141
+ + + Y C A+ + + + + P+ IH S G + V CS A
Sbjct: 458 SGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQ-VSIHTSSQHFSQGVEVKVSCS-AS 515
Query: 142 VYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHI 201
YP + + + L++ R ++ + + ED G C+A
Sbjct: 516 GYPTPHISWS--------RESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYS-CQAT--- 563
Query: 202 DEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK 261
+ V T ++ V +Y + +V +VN + G + C + G+P P + W +
Sbjct: 564 ---NEVGTDQETVT---LYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR- 616
Query: 262 LDNGNLQHL-----SGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVE 316
G L+ + S + L + A + D+G Y C VN +G E++L V P E
Sbjct: 617 ---GGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTE 673
Query: 317 ISPGPR-IAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLS-------GKVRSEGTNSTL 368
+ PR + ++G S +L C G P+ +WR PL G + + L
Sbjct: 674 L---PRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVL 730
Query: 369 TLSPVSFENEHSYLCTV--TCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCK 426
V+ E++ Y+C G + E + V ++ P+ + ++ G V++ C
Sbjct: 731 FFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCI 790
Query: 427 VPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAK 486
V + PL +L+D P + ++
Sbjct: 791 VLAGRPLPERH--------------WLKDGR--------------PLPPGSRHSIRADGS 822
Query: 487 LHIDDMEFEPKQRQS---TQT---------LYVNVAPRDTTVLVSPSS---ILEEGSSVN 531
LH+D E R S T T L V V PR + P++ I EG +
Sbjct: 823 LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPR-----IHPTATHHITNEGVPAS 877
Query: 532 MTCLSQGFPAPKILWSRQL----PNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGR 587
+ C++ G PAP I W+++ G +S+ TL + +D+G Y+C N G
Sbjct: 878 LPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGF 937
Query: 588 SRKEVELIIQVTPKDIKLTAFPSESV------KEGDTVIISCTCGNVPETWIILKKKAET 641
S +E+ L + P+ I + + +V K G+ V + C P + K +
Sbjct: 938 SSQEMRLSVNTKPR-IHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRP 996
Query: 642 GDTVLKSI----DGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGR 688
+ G+ + + Q+ D+G YEC + N GS L VQGR
Sbjct: 997 VPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGR 1047
Score = 85.9 bits (211), Expect = 1e-16
Identities = 95/430 (22%), Positives = 171/430 (39%), Gaps = 37/430 (8%)
Query: 271 SGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDS 330
SGN++ ++ + G Y C V+ G R + +++V + P ++ P P + G++
Sbjct: 359 SGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPP--PQLVPAPNVTVSPGET 416
Query: 331 VMLTCSVMGCESPSFSW-RTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGH 389
+L+C V+G + +W R P S ++ + +L +S + + Y C + +
Sbjct: 417 AVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNAN 476
Query: 390 KKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILEN 449
+ + + P+ S G V VSC S YP + E+
Sbjct: 477 GVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSA-SGYPTPHISWS-------RES 528
Query: 450 IEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNV 509
ED+ + +L + + ED G CQA + Q T TLY
Sbjct: 529 QALQEDSRIHVDAQGTLIIQGVAP-EDAGN-YSCQATNEVG-------TDQETVTLYYTD 579
Query: 510 APRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPL-SENATLTLIS 568
P + V+ ++ G + C + G P P+++W R L P S + L + +
Sbjct: 580 PP--SVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPA 637
Query: 569 TKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSE-SVKEGDTVIISCTCGN 627
+ D+G Y C +N+ G + E++L + P +LT P + +V+ G + +++C
Sbjct: 638 AQERDAGTYTCRAVNELGDASAEIQLAVGHAP---QLTELPRDVTVELGRSALLACRATG 694
Query: 628 VPE---TW-------IILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQ 677
P TW + L+ A G + G +D Y CE++N G
Sbjct: 695 RPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKV 754
Query: 678 LRSLTLDVQG 687
L V G
Sbjct: 755 QAEARLIVTG 764
Score = 81.3 bits (199), Expect = 3e-15
Identities = 131/612 (21%), Positives = 217/612 (35%), Gaps = 78/612 (12%)
Query: 15 LWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNE 74
+W++ + I T+ S++ +Q G V ++CS +G +P SW + + +
Sbjct: 483 VWLLVREAPQVSIHTS--SQHFSQ-GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV 539
Query: 75 GTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPIT 134
TL + V+ + +Y C AT E ++ + + P ++ + G+
Sbjct: 540 DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAV 599
Query: 135 VKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLV 194
+ C + V P R LE+ P GK+ +
Sbjct: 600 LVCEASGVPP------------------------PRVIWYRGGLEMILAPEGSSSGKLRI 635
Query: 195 CRAKLHIDEMDSVPTVRQAVKEL-------QVYISPKNTVISVNPSTKLQEGGSVTMTCS 247
A+ E D+ +AV EL Q+ + + + ++ G S + C
Sbjct: 636 PAAQ----ERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACR 691
Query: 248 SEGLPAPEIFWSK----------KLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLI 297
+ G P P + W + G+ + L ++ ED YVCE N+
Sbjct: 692 ATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVF 751
Query: 298 GKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVM-GCESPSFSWRTQIDSPLS 356
GK + E LIV S P + G V L C V+ G P W
Sbjct: 752 GKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPP 811
Query: 357 GKVRSEGTNSTLTLSPVSFENEHSYLCTVT----CGHKKLEKGIQVELYSFPRDPEIEMS 412
G S + +L L E+ Y C T H+ +E +QV P +
Sbjct: 812 GSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITN 871
Query: 413 GGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFI- 471
G V S V+ VP+ TI E T N S E T +
Sbjct: 872 EG-VPASLPCVASGVPA--------------PTITWTKETNALTSRGPHYNVSKEGTLLI 916
Query: 472 --PTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSS 529
P+ +D G A VC A + E + +T+ R+ V + ++ + G
Sbjct: 917 AQPSAQDAG-AYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTA--KAGEE 973
Query: 530 VNMTCLSQGFPAPKILWSRQL----PNGELQPLSENATLTLISTKMEDSGVYLCEGINQA 585
V + C ++G P P + W++ P L + +L L ++ DSG Y C N A
Sbjct: 974 VTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPA 1033
Query: 586 GRSRKEVELIIQ 597
G + L +Q
Sbjct: 1034 GSASHRYVLGVQ 1045
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 115 bits (288), Expect = 1e-25
Identities = 114/477 (23%), Positives = 192/477 (40%), Gaps = 42/477 (8%)
Query: 228 ISVNPSTK-LQEGGSVTMTCSSEGLPAPEIFWSKK---LDNGNLQHLSGNATLTLIAMRM 283
+S++ S++ +G V ++CS+ G P P I WS++ L + H+ TL + +
Sbjct: 610 VSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAP 669
Query: 284 EDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESP 343
ED+G Y C+ N +G +++ V L + P ++ +A +G+ +L C G P
Sbjct: 670 EDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVA--VGEEAVLVCEASGVPPP 727
Query: 344 SFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEH-SYLCTVT------CGHKKLEKGI 396
W L + EG++S P + E + +Y C +L G
Sbjct: 728 RVIWYR---GGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGH 784
Query: 397 QVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDT 456
+L PRD +E+ G S ++C+ P + +G+ +
Sbjct: 785 APQLTELPRDVTVEL------GRSALLACRATGRPPPT---VTWRRGDGQPLGLRLGAGR 835
Query: 457 DMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTV 516
+S + S + F + VC+A+ ++ E + L V
Sbjct: 836 GSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEAR-------LIVTGHAPPQIA 888
Query: 517 LVSPSSILEEGSSVNMTCLS-QGFPAPKILW---SRQLPNGELQPLSENATLTLISTKME 572
+P+ + EG V++ C+ G P P+ W R LP G + + +L L E
Sbjct: 889 SSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQE 948
Query: 573 DSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETW 632
+G Y C N AG ++VEL++QV P+ I TA EG + C VP
Sbjct: 949 HAGRYSCVATNTAGSQHRDVELVVQVPPR-IHPTA-THHITNEGVPASLPCVASGVPAPT 1006
Query: 633 IILKKKAET----GDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 685
I K+ G S +G I + +DAG Y C + N VG + + L V
Sbjct: 1007 ITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 1063
Score = 108 bits (271), Expect = 1e-23
Identities = 124/489 (25%), Positives = 196/489 (40%), Gaps = 66/489 (13%)
Query: 235 KLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGV 294
K+ G ++ + C +EG P P++ WSK D LQ ++ A+R D+G Y CE
Sbjct: 1130 KVLVGEALDLNCVAEGNPEPQLSWSK--DGVVLQGRGPQGSVHFAAIRTSDAGRYRCEAS 1187
Query: 295 NLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDS- 353
N G + EVEL V E P + G++ L C G P +WR S
Sbjct: 1188 NSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSE 1247
Query: 354 PLSGK----VRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEI 409
PL G+ V EG +L L+ VS + Y C T + ++ +Y P I
Sbjct: 1248 PLHGQPGVAVLEEG---SLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYV---PPSI 1301
Query: 410 EMSGGLVN-----GSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENK 464
G N G S+T+ C + +P + I +L+D +
Sbjct: 1302 REDGRKANVSGMAGQSLTLECDA-NGFP--------------VPEIVWLKDAQL-----V 1341
Query: 465 SLEMTFIPTIEDTGKALVCQAKLHIDDMEFE-PKQRQSTQTLY-------VNVAPRDTTV 516
+ + + D G V +L + P+ ++ LY A RD +
Sbjct: 1342 GVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHL 1401
Query: 517 LV-SPSSILEEGSS----------VNMTCLSQGFPAPKILWSRQ----LPNG-ELQPLSE 560
LV +P S+L G++ V + C + G P P++ W++ LP G LQ +
Sbjct: 1402 LVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQED 1461
Query: 561 NATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVI 620
L + + + D G Y C + AG+ ++ +L + P +V E V
Sbjct: 1462 GQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQ 1521
Query: 621 ISCTCGNVPE---TWIILKKKAETGDTVLKSIDG-AYTIRKAQLKDAGVYECESKNKVGS 676
+ C VP TW T V+ + G + +AQ DAGVY C++ N VG+
Sbjct: 1522 LLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGA 1581
Query: 677 QLRSLTLDV 685
++ LDV
Sbjct: 1582 AEKATRLDV 1590
Score = 103 bits (258), Expect = 4e-22
Identities = 126/500 (25%), Positives = 210/500 (42%), Gaps = 76/500 (15%)
Query: 235 KLQEGGSVTMTCSSEGLPAPEIFWSKK----LDNGNLQHLSGNATLTLIAMRMEDSGIYV 290
K + ++T+ C S +P P I W K + LQ L L + ++ DSG Y+
Sbjct: 2650 KTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYL 2709
Query: 291 CEGVNLIGKNRKEVELIVQEKPFTVEISP----------------GPRIAAQIGDS--VM 332
C N+ G++ ++ +++Q P ++ G +I ++
Sbjct: 2710 CVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAY 2769
Query: 333 LTCSVMGCESPSFSWRTQIDSPLSG--KVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHK 390
L C P +W + D PLS +V L + V EN Y C + ++
Sbjct: 2770 LYCDTNAIPPPDLTWYRE-DQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKAS--NE 2826
Query: 391 KLEKGIQVELYSFPR-----DPEIEMSGGLVNGSSVTVSCKVPSV-YPLDRLEIELLKGE 444
E + EL D E + VN SS TVS + P++ P+ +
Sbjct: 2827 VGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS-TVSLQCPALGNPVPTIS------- 2878
Query: 445 TILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQT 504
+ + F ++ LE+ + + D + +C A E + + T
Sbjct: 2879 WLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAA-SYMCVA-------ENQAGSAEKLFT 2930
Query: 505 LYVNVAPRDTTV-LVSPSSILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGE-LQPLS 559
L V V PR + L ++IL SSV++ C P P++ W S+ L GE + L
Sbjct: 2931 LRVQVPPRIAGLDLEQVTAILN--SSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLP 2988
Query: 560 ENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSES--VKEGD 617
TL L ++ DSG+Y CE +N AGR +K V+L + V P + P ++ V+ GD
Sbjct: 2989 GTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGD 3048
Query: 618 TVIISCTCGNVPE---TW------IILKKKAET--GDTVLKSIDGAYTIRKAQLKDAGVY 666
++SC +PE TW ++L ++ + G L+ I++AQ+ D G+Y
Sbjct: 3049 KAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLE-------IQEAQVSDKGLY 3101
Query: 667 ECESKNKVGSQLRSLTLDVQ 686
C+ N G +R+ TL VQ
Sbjct: 3102 SCKVSNVAGEAVRTFTLTVQ 3121
Score = 102 bits (254), Expect = 1e-21
Identities = 159/682 (23%), Positives = 251/682 (36%), Gaps = 88/682 (12%)
Query: 42 SVSLTCSTTGCESPFFSW---RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTAT 98
SV+L C +G P SW + S + V+ +G L + + SY C A+
Sbjct: 1902 SVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV--LRIEQAQLSDAGSYRCVAS 1959
Query: 99 --CESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGD 156
S +L G++V + P L GP+ P+ + C+
Sbjct: 1960 NVAGSTELRYGLRVNVPPRITLPP-SLPGPVLVNTPVRLTCNATGA-----------PSP 2007
Query: 157 HLMKSQEFLEDADRKS-LETKSLEVTFTPVIEDIGKVLVCRAKLHIDE-------MDSVP 208
LM +L+D + S T L+V G+VL + D + +V
Sbjct: 2008 TLM----WLKDGNPVSPAGTPGLQVF------PGGRVLTLASARASDSGRYSCVAVSAVG 2057
Query: 209 TVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK---LDNG 265
RQ V LQV++ P +N S E SV + C S +P P + W K L+
Sbjct: 2058 EDRQDVV-LQVHMPPSILGEELNVSVVANE--SVALECQSHAMPPPVLSWWKDGRPLEPR 2114
Query: 266 NLQHLSGN-ATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIA 324
HLS + A L + + D+G Y CE +N G + K L V P + +
Sbjct: 2115 PGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAP-VFPLRESHTLT 2173
Query: 325 AQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRS----EGTNSTLTLSPVSFENEHS 380
+ G L+C G P SWR PL G+ L L E +
Sbjct: 2174 VREGHPTSLSCECRGVPFPKISWRKD-GQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGT 2232
Query: 381 YLCTVTCGHKKLEKGIQVELY-----SFPRDPEIEMSGGLVNGSSVTVSC----KVPSVY 431
Y C + + +Q+E++ + PR+P ++S +V T+ C K P
Sbjct: 2233 YTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVS--VVQDGVATLECNATGKPPPTV 2290
Query: 432 PLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDD 491
+R G+ + + +SL + + + L +A+ +
Sbjct: 2291 TWER------DGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFEL 2344
Query: 492 MEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQ-- 549
P + N+ T L SP ++L C + G P P I W R
Sbjct: 2345 SVLVPPELIGDLDPLTNI----TAALHSPLTLL---------CEAMGIPPPAIRWFRGEE 2391
Query: 550 --LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTA 607
P + L+ L + T+ +DSG+Y C N+AG +R+ + + V P
Sbjct: 2392 PVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDL 2451
Query: 608 FPSESVKEGDTVIISCTCGNVPE---TWIILKKKAETGDTVLKSIDGA-YTIRKAQLKDA 663
V +G T + C P+ TW + GD S DG + +A L A
Sbjct: 2452 EEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSA 2511
Query: 664 GVYECESKNKVGSQLRSLTLDV 685
G Y C + N VG + + L V
Sbjct: 2512 GHYSCIAANAVGEKTKHFQLSV 2533
Score = 100 bits (250), Expect = 4e-21
Identities = 159/675 (23%), Positives = 257/675 (38%), Gaps = 88/675 (13%)
Query: 40 GDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATC 99
G V L C G P SW PL + +G + L + V G+ +Y C A
Sbjct: 3421 GSLVELPCEARGVPLPLVSWMKD-GEPLLSQSLEQGPS--LQLEAVGAGDSGTYSCVAVS 3477
Query: 100 ESRKLEKGIQVEIYSFPKDPEIHLSGP-----LEAGKPITVKCSVADVYPFDRLEIDLLK 154
E+ + + Q+ + + P I SG L G P+ + C A P +
Sbjct: 3478 EAGEARRHFQLTVM---EPPHIEDSGQPTELSLTPGAPMELLCD-AQGTPQPNITWH--- 3530
Query: 155 GDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAV 214
K + L + S T+ L V D G + C A+ ++ VR
Sbjct: 3531 -----KDGQALTRLENNSRATRVLRV------RDAG-LYTCLAESPAGAIEKSFRVRVQA 3578
Query: 215 KELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK----LDNGNLQHL 270
V V+ + P G + + CS E PAP+I W + ++ + Q
Sbjct: 3579 PPNIVGPRGPRFVVGLAP-------GQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFP 3631
Query: 271 SGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDS 330
L L A+ DSG Y C N G + + P T+ P P + + +
Sbjct: 3632 ERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVP-TIRSGP-PAVNVSVNQT 3689
Query: 331 VMLTCSVMGCESPSFSWRTQIDSPLSGK-----VRSEGTNSTLTLSPVSFENEHSYLCTV 385
+L C G +P SWR PL + + EG+ L + PV ++ YLC
Sbjct: 3690 ALLPCQADGVPAPLVSWRKD-RVPLDPRSPRFEILPEGS---LRIQPVLAQDAGHYLCLA 3745
Query: 386 TCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDR------LEIE 439
+ +G + + P I S S++T++ P++ P + L +
Sbjct: 3746 SNSAGSDRQGRDLRVLE---PPAIAPSP-----SNLTLTAHTPALLPCEASGSPKPLVVW 3797
Query: 440 LLKGETILENIEF-LEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQ 498
G+ ++F L+ + L + +L +T P +D+ + C + + +
Sbjct: 3798 WKDGQ----KLDFRLQQGAYRLLPSNALLLT-APGPQDSAQ-FECVVSNEVGEAH---RL 3848
Query: 499 RQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSR---QL-PNGE 554
Q T + +A T V+ + V +TC S G PAP + WS+ QL G
Sbjct: 3849 YQVTVHVPPTIADDQTDFTVTMMA------PVVLTCHSTGIPAPTVSWSKAGAQLGARGS 3902
Query: 555 LQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVK 614
+S + L + +G Y C N AG + K V L +Q +P +K +V
Sbjct: 3903 GYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPV-VKPLPSVVRAVA 3961
Query: 615 EGDTVIISCTCGNVPETWIILKKK---AETGDTVLKSIDGAYTIRKAQLKDAGVYECESK 671
E + V++ C +P I +K+ TG + G I A +DAG Y C +K
Sbjct: 3962 E-EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAK 4020
Query: 672 NKVGSQLRSLTLDVQ 686
N GS + L VQ
Sbjct: 4021 NSAGSAMGKTRLVVQ 4035
Score = 100 bits (249), Expect = 5e-21
Identities = 150/699 (21%), Positives = 259/699 (37%), Gaps = 140/699 (20%)
Query: 28 ETTPESRYLAQIGDSVSLTCSTTGCESPFF-----SWRTQIDSPLNGKVTNEGTTSTLTM 82
+ P G++ L+C G E+P+ WR S G+V S L +
Sbjct: 519 QLVPAPNVTVSPGETAVLSCRVLG-EAPYNLTWVRDWRVLPAS--TGRVAQLADLS-LEI 574
Query: 83 NPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGP-LEAGKPITVKCSVAD 141
+ + + Y C A+ + + + + P+ IH S G + V CS A
Sbjct: 575 SGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQ-VSIHTSSQHFSQGVEVKVSCS-AS 632
Query: 142 VYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHI 201
YP + + + L++ R ++ + + ED G C+A
Sbjct: 633 GYPTPHISWS--------RESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYS-CQAT--- 680
Query: 202 DEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK 261
+ V T ++ V +Y + +V +VN + G + C + G+P P + W +
Sbjct: 681 ---NEVGTDQETVT---LYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR- 733
Query: 262 LDNGNLQHL-----SGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVE 316
G L+ + S + L + A + D+G Y C VN +G E++L V P E
Sbjct: 734 ---GGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTE 790
Query: 317 ISPGPR-IAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLS-------GKVRSEGTNSTL 368
+ PR + ++G S +L C G P+ +WR PL G + + L
Sbjct: 791 L---PRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVL 847
Query: 369 TLSPVSFENEHSYLCTV--TCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCK 426
V+ E++ Y+C G + E + V ++ P+ + ++ G V++ C
Sbjct: 848 FFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCI 907
Query: 427 VPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAK 486
V + PL +L+D P + ++
Sbjct: 908 VLAGRPLPER--------------HWLKDGR--------------PLPPGSRHSIRADGS 939
Query: 487 LHIDDMEFEPKQRQS---TQT---------LYVNVAPRDTTVLVSPSS---ILEEGSSVN 531
LH+D E R S T T L V V PR + P++ I EG +
Sbjct: 940 LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPR-----IHPTATHHITNEGVPAS 994
Query: 532 MTCLSQGFPAPKILWSRQ----LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGR 587
+ C++ G PAP I W+++ G +S+ TL + +D+G Y+C N G
Sbjct: 995 LPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGF 1054
Query: 588 SRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLK 647
S +E+ L + + L+ + E G +P
Sbjct: 1055 SSQEMRLSV----NRLALSKYVWEEY------------GLLP------------------ 1080
Query: 648 SIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 686
G+ + + Q+ D+G YEC + N GS L VQ
Sbjct: 1081 --SGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQ 1117
Score = 98.6 bits (244), Expect = 2e-20
Identities = 106/465 (22%), Positives = 184/465 (39%), Gaps = 51/465 (10%)
Query: 242 VTMTCSSEGLPAPEIFWSKK---LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIG 298
V + C + G+P P I W K+ + G + L + ED+G Y+C N G
Sbjct: 3965 VLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAG 4024
Query: 299 KNRKEVELIVQEKPFTVEISPG-PRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSG 357
+ L+VQ P I G P ++ G L C G P+ +W P+SG
Sbjct: 4025 SAMGKTRLVVQVPPV---IENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKD-GQPVSG 4080
Query: 358 KVRSEGT-----NSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMS 412
+EG + L + + ++ +Y CT + + + + + P +
Sbjct: 4081 ---AEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGD 4137
Query: 413 GGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIP 472
L G + + C P R+ + + E + E +L+ ++
Sbjct: 4138 RSLRLGDRLWLRCAARGS-PTPRIGWTV-NDRPVTEGVS--EQDGGSTLQRAAVSR---- 4189
Query: 473 TIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAP----RDTTVLVSPSSILEEGS 528
ED+G VC A+ + + Q+ ++V AP + LV P G
Sbjct: 4190 --EDSG-TYVCWAENRVG-------RTQAVSFVHVKEAPVLQGEAFSYLVEPV-----GG 4234
Query: 529 SVNMTCLSQGFPAPKILWSRQ---LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQA 585
S+ + C+ +G P P I W + L L+ +N +LT+ T+ +D+G Y C N+
Sbjct: 4235 SIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEM 4294
Query: 586 GRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWIILKKKAETG 642
G ++K V L++Q P + +V+ GD V + C P W+ +
Sbjct: 4295 GVAKKVVILVLQSAP--VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRAS 4352
Query: 643 DTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQG 687
+ DG+ + + DAG Y+C + N +GS L V+G
Sbjct: 4353 RRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRG 4397
Score = 98.2 bits (243), Expect = 2e-20
Identities = 155/703 (22%), Positives = 266/703 (37%), Gaps = 98/703 (13%)
Query: 40 GDSVSLTCSTTGCESPFFSWRTQIDS-PLNGK----VTNEGTTSTLTMNPVSFGNEHSYL 94
G++ SL C G P +WR S PL+G+ V EG+ +++P G+ Y
Sbjct: 1221 GENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGD---YE 1277
Query: 95 CTATCESRKLEKGIQVEIYSFPKDPE----IHLSGPLEAGKPITVKCSVADVYPFDRLEI 150
C AT E + ++ +Y P E ++SG AG+ +T++C D F EI
Sbjct: 1278 CQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGM--AGQSLTLEC---DANGFPVPEI 1332
Query: 151 DLLKGDHLMK----------SQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLH 200
LK L+ + + + L+ + + F + E + CRA+
Sbjct: 1333 VWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLD-EGQSLHFPRIQEGDSGLYSCRAENQ 1391
Query: 201 IDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQ--EGGSVTMTCSSEGLPAPEIFW 258
A ++ + + +V+ + ++ G V + C + G+P P++ W
Sbjct: 1392 AGT---------AQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEW 1442
Query: 259 SKK----LDNG-NLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPF 313
+K L G +LQ L + + D G Y C + G+ ++ +L V P
Sbjct: 1443 TKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPT 1502
Query: 314 TVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSW-RTQIDSPLSGKVRSEGTNSTLTLSP 372
+ +A V L C G +P+ +W + P S KV L L
Sbjct: 1503 IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGR 1562
Query: 373 VSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGG------LVNGSSVTVSCK 426
+ Y C + EK ++++Y P IE +GG V G V + C
Sbjct: 1563 AQSSDAGVYTCKASNAVGAAEKATRLDVYV---PPTIEGAGGRPYVVKAVAGRPVALEC- 1618
Query: 427 VPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGK-ALVCQA 485
V +P L +G + E+ E +TD L +S P +G + V +
Sbjct: 1619 VARGHPSPTLSWHH-EGLPVAESNESRLETDGSVLRLES------PGEASSGLYSCVASS 1671
Query: 486 KLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKIL 545
+++ + + Q L + TT++ G + + C + G P P I
Sbjct: 1672 PAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIV---------GQPLELPCQASGSPVPTIQ 1722
Query: 546 WSRQLPNGE-------LQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELII-- 596
W L NG +Q S+ TL + +++ SG++ C+ N+AG + EVE+ +
Sbjct: 1723 W---LQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHG 1779
Query: 597 QVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKK--------------AETG 642
+ P +++ E + + V W K TG
Sbjct: 1780 EWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTG 1839
Query: 643 DTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 685
V S+ I K L+D G+Y C + N G R + L V
Sbjct: 1840 IPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKV 1882
Score = 94.7 bits (234), Expect = 3e-19
Identities = 125/512 (24%), Positives = 197/512 (38%), Gaps = 82/512 (16%)
Query: 212 QAVKELQVYISPKNTVISVNPSTKL--QEGGSVTMTCSSEGLPAPEIFWSKK----LDNG 265
Q ++ Q+ + T+ N + ++ E V + C + G+P P I W K +
Sbjct: 1488 QQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTST 1547
Query: 266 NLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPR--I 323
+ + G L L + D+G+Y C+ N +G K L V P T+E + G +
Sbjct: 1548 KVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPP-TIEGAGGRPYVV 1606
Query: 324 AAQIGDSVMLTCSVMGCESPSFSWRTQ-IDSPLSGKVRSEGTNSTLTLSPVSFENEHSYL 382
A G V L C G SP+ SW + + S + R E S L L + Y
Sbjct: 1607 KAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYS 1666
Query: 383 CTVT--CGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIEL 440
C + G L+ ++V++ P++ ++ GL VT P LE+
Sbjct: 1667 CVASSPAGEAVLQYSVEVQV-----PPQLLVAEGL---GQVTTIVGQP-------LELPC 1711
Query: 441 LKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAK-LHIDDMEFEPKQR 499
+ + I++L++ P E G + Q LHID +E +
Sbjct: 1712 QASGSPVPTIQWLQNGR--------------PAEELAGVQVASQGTTLHIDHVELDHSGL 1757
Query: 500 QSTQ-TLYVNVAPRDTTVLV----SPSSI----------LEEGSSVNMTC---------- 534
+ Q T A + V V +P + E SS C
Sbjct: 1758 FACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGA 1817
Query: 535 -----LSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSR 589
L +G+ +P LW P G S L + + D G+Y C N AG S+
Sbjct: 1818 HPKPPLVEGWCSPGSLWGE--PTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESK 1875
Query: 590 KEVELIIQVTPKDIKLTAFP-SESVKEGDTVIISCTCGNVPE---TWIILKKKAETGDTV 645
+EV L + V P + P +++V E +V + C VP +W + + V
Sbjct: 1876 REVALKVLVPP---NIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGV 1932
Query: 646 LKSIDG-AYTIRKAQLKDAGVYECESKNKVGS 676
S+DG I +AQL DAG Y C + N GS
Sbjct: 1933 TVSVDGRVLRIEQAQLSDAGSYRCVASNVAGS 1964
Score = 93.2 bits (230), Expect = 8e-19
Identities = 151/706 (21%), Positives = 264/706 (37%), Gaps = 85/706 (12%)
Query: 37 AQIGDSVSLTCSTTGCESPFFSWRTQIDS-PLNGKVTNEGTTSTLTMNPVSFGNEHSYLC 95
A + SVSL C +P +W + L +V T TL + + Y C
Sbjct: 2949 AILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTC 3008
Query: 96 TATCESRKLEKGIQVEIY---SFPKDPEIHLSGPLEA-----GKPITVKCSVADVYPFDR 147
A + + +K +Q+ + +F + P GP +A G + C D P
Sbjct: 3009 EALNAAGRDQKLVQLSVLVPPAFRQAPR----GPQDAVLVRVGDKAVLSCET-DALPEPT 3063
Query: 148 LEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSV 207
+ G L+ +Q + LE + +V+ D G + K+ ++V
Sbjct: 3064 VTW-YKDGQPLVLAQRTQALRGGQRLEIQEAQVS------DKG---LYSCKVSNVAGEAV 3113
Query: 208 PTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLD--NG 265
T V+ + +PK +S G + +TC G+PAP + W K
Sbjct: 3114 RTFTLTVQVPPTFENPKTETVSQ------VAGSPLVLTCDVSGVPAPTVTWLKDRMPVES 3167
Query: 266 NLQH--LSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRI 323
+ H +S L L ++ +G Y C N + RK+ F V + PRI
Sbjct: 3168 SAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKD---------FVVAVLVAPRI 3218
Query: 324 AAQ---------IGDSVMLTCSVMGCESPSFSWR---TQIDSPLSGKVRSEGTNSTLTLS 371
+ G V L C G P +W + + + +R +L L
Sbjct: 3219 RSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLK 3278
Query: 372 PVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEM----SGGLVN--GSSVTVSC 425
+ + +Y C H + ++ + P I+ SG LV+ G VT+ C
Sbjct: 3279 GLRASDAGAYTCVA---HNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVC 3335
Query: 426 KVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQA 485
V P+ + LK L L + +L ++ + + V +
Sbjct: 3336 PVRGSPPI---HVSWLKDGLPLP----LSQRTLLHGSGHTLRISKVQLADAGIFTCVAAS 3388
Query: 486 KLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKIL 545
+ D F TL V V P V ++ GS V + C ++G P P +
Sbjct: 3389 PAGVADRNF---------TLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVS 3439
Query: 546 WSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKL 605
W + Q L + +L L + DSG Y C +++AG +R+ +L + + P I+
Sbjct: 3440 WMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTV-MEPPHIED 3498
Query: 606 TAFPSE-SVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAG 664
+ P+E S+ G + + C P+ I K G + + + + R +++DAG
Sbjct: 3499 SGQPTELSLTPGAPMELLCDAQGTPQPNITWHK---DGQALTRLENNSRATRVLRVRDAG 3555
Query: 665 VYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLII 710
+Y C +++ G+ +S + VQ N P +V L++
Sbjct: 3556 LYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVL 3601
Score = 92.0 bits (227), Expect = 2e-18
Identities = 163/700 (23%), Positives = 247/700 (35%), Gaps = 112/700 (16%)
Query: 31 PESRYLAQI-GDSVSLTCSTTGCESPFFSW---RTQIDSP-LNGKVTNEGTTSTLTMNPV 85
P++ ++Q+ G + LTC +G +P +W R ++S ++G V+ G + P
Sbjct: 3129 PKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPA 3188
Query: 86 SFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEA-----GKPITVKCSVA 140
G +Y C A + K V + P+ I SG G+ + + C
Sbjct: 3189 QAG---TYTCVAENTQAEARKDFVVAVLVAPR---IRSSGVAREHHVLEGQEVRLDCEAD 3242
Query: 141 DVYPFDR--LEIDLLKGDHLMKSQEFLEDADRKSLETKSLE---------VTFTPVIEDI 189
P D L+ G + F D SL K L V P ED
Sbjct: 3243 GQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG--SLVLKGLRASDAGAYTCVAHNPAGED- 3299
Query: 190 GKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSE 249
A+LH + PT++Q T++S + G VTM C
Sbjct: 3300 -------ARLHTVNVLVPPTIKQGA-------DGSGTLVS-------RPGELVTMVCPVR 3338
Query: 250 GLPAPEIFWSKK-----LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV 304
G P + W K L L H SG+ TL + +++ D+GI+ C + G +
Sbjct: 3339 GSPPIHVSWLKDGLPLPLSQRTLLHGSGH-TLRISKVQLADAGIFTCVAASPAGVADRNF 3397
Query: 305 ELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGT 364
L VQ P + + G V L C G P SW PL + +G
Sbjct: 3398 TLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKD-GEPLLSQSLEQGP 3456
Query: 365 NSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSG-----GLVNGS 419
+ L L V + +Y C + + Q+ + P IE SG L G+
Sbjct: 3457 S--LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVME---PPHIEDSGQPTELSLTPGA 3511
Query: 420 SVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTD-MKSLENKSLEMTFIPTIEDTG 478
+ + C T NI + +D + LEN S T + + D G
Sbjct: 3512 PMELLCDAQG---------------TPQPNITWHKDGQALTRLENNS-RATRVLRVRDAG 3555
Query: 479 KALVCQAKLHIDDMEFEPKQR-QSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQ 537
C A+ +E + R Q+ + PR L +LE C +
Sbjct: 3556 -LYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLE--------CSVE 3606
Query: 538 GFPAPKILWSRQ----LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVE 593
PAPKI W R + Q L L + DSG Y C N AG +
Sbjct: 3607 AEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 3666
Query: 594 LIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSID--- 650
+ I P + P+ +V T ++ C VP + +K D +
Sbjct: 3667 VEIHTVPTI--RSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILP 3724
Query: 651 -GAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRE 689
G+ I+ +DAG Y C + N GS D QGR+
Sbjct: 3725 EGSLRIQPVLAQDAGHYLCLASNSAGS-------DRQGRD 3757
Score = 89.4 bits (220), Expect = 1e-17
Identities = 107/426 (25%), Positives = 168/426 (39%), Gaps = 53/426 (12%)
Query: 283 MEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGD-SVMLTCSVMGCE 341
+ D GIY C NL G++++EV L V P I PGP A + + SV L C G
Sbjct: 1857 LRDEGIYTCAATNLAGESKREVALKVLVPP---NIEPGPVNKAVLENASVTLECLASGVP 1913
Query: 342 SPSFSW---RTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVT--CGHKKLEKGI 396
P SW + S + V +G L + + SY C + G +L G+
Sbjct: 1914 PPDVSWFKGHQPVSSWMGVTVSVDGR--VLRIEQAQLSDAGSYRCVASNVAGSTELRYGL 1971
Query: 397 QVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDT 456
+V + P + G ++ + V ++C T++ +L+D
Sbjct: 1972 RVNVPPRITLPP-SLPGPVLVNTPVRLTCNATGA-----------PSPTLM----WLKDG 2015
Query: 457 DMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFE-------PKQRQSTQTLYVNV 509
+ S F G+ L + D + + RQ L V++
Sbjct: 2016 NPVSPAGTPGLQVF-----PGGRVLTLASARASDSGRYSCVAVSAVGEDRQDV-VLQVHM 2069
Query: 510 APRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILW---SRQL-PNGELQPLSENATLT 565
P ++ S + E SV + C S P P + W R L P + ++ A L
Sbjct: 2070 PPSILGEELNVSVVANE--SVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQ 2127
Query: 566 LISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTC 625
+ + D+G Y CE +NQAG S K L + V P L + +V+EG +SC C
Sbjct: 2128 VDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPV-FPLRESHTLTVREGHPTSLSCEC 2186
Query: 626 GNVPETWIILKKKAE------TGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLR 679
VP I +K + G + ++ + +AQL G Y CE N VG+ +
Sbjct: 2187 RGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQ 2246
Query: 680 SLTLDV 685
L L+V
Sbjct: 2247 DLQLEV 2252
Score = 85.9 bits (211), Expect = 1e-16
Identities = 95/430 (22%), Positives = 171/430 (39%), Gaps = 37/430 (8%)
Query: 271 SGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDS 330
SGN++ ++ + G Y C V+ G R + +++V + P ++ P P + G++
Sbjct: 476 SGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPP--PQLVPAPNVTVSPGET 533
Query: 331 VMLTCSVMGCESPSFSW-RTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGH 389
+L+C V+G + +W R P S ++ + +L +S + + Y C + +
Sbjct: 534 AVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNAN 593
Query: 390 KKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILEN 449
+ + + P+ S G V VSC S YP + E+
Sbjct: 594 GVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSA-SGYPTPHISWS-------RES 645
Query: 450 IEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNV 509
ED+ + +L + + ED G CQA + Q T TLY
Sbjct: 646 QALQEDSRIHVDAQGTLIIQGVAP-EDAGN-YSCQATNEVG-------TDQETVTLYYTD 696
Query: 510 APRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPL-SENATLTLIS 568
P + V+ ++ G + C + G P P+++W R L P S + L + +
Sbjct: 697 PP--SVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPA 754
Query: 569 TKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSE-SVKEGDTVIISCTCGN 627
+ D+G Y C +N+ G + E++L + P +LT P + +V+ G + +++C
Sbjct: 755 AQERDAGTYTCRAVNELGDASAEIQLAVGHAP---QLTELPRDVTVELGRSALLACRATG 811
Query: 628 VPE---TW-------IILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQ 677
P TW + L+ A G + G +D Y CE++N G
Sbjct: 812 RPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKV 871
Query: 678 LRSLTLDVQG 687
L V G
Sbjct: 872 QAEARLIVTG 881
Score = 83.6 bits (205), Expect = 6e-16
Identities = 130/583 (22%), Positives = 214/583 (36%), Gaps = 80/583 (13%)
Query: 43 VSLTCSTTGCESPFFSWR---TQIDSPLNG-KVTNEGTTSTLTMNPVSFGNEHSYLCTAT 98
V LTC +TG +P SW Q+ + +G +V+ G P+ G Y C+A
Sbjct: 3874 VVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGR---YTCSAR 3930
Query: 99 CESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHL 158
+ K + + + + P + A + + + C + + R I K
Sbjct: 3931 NSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGI---PRPTITWQK---- 3983
Query: 159 MKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQ 218
+ + L L + ED G L C AK + A+ + +
Sbjct: 3984 -EGLNVATGVSTQVLPGGQLRIAHASP-EDAGNYL-CIAK---------NSAGSAMGKTR 4031
Query: 219 VYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATL-- 276
+ + + + P EG + C + G P P I W K D + G T+
Sbjct: 4032 LVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDK--DGQPVSGAEGKFTIQP 4089
Query: 277 --TLIAMRME--DSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVM 332
L+ +E D+G Y C N +G+ R+ V L + P + PG R + ++GD +
Sbjct: 4090 SGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTL-PGDR-SLRLGDRLW 4147
Query: 333 LTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLC--------- 383
L C+ G +P W T D P++ V + STL + VS E+ +Y+C
Sbjct: 4148 LRCAARGSPTPRIGW-TVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRT 4206
Query: 384 -TVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLK 442
V+ H K +Q E +S+ +E GG + V VP ++
Sbjct: 4207 QAVSFVHVKEAPVLQGEAFSY----LVEPVGGSIQLDCVVRGDPVPDIH----------- 4251
Query: 443 GETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQST 502
I + + L+N SL T T D C A E E +
Sbjct: 4252 --WIKDGLPLRGSHLRHQLQNGSL--TIHRTERDDAGRYQCLA-------ENEMGVAKKV 4300
Query: 503 QTLYVNVAPRDTTVLVSPSSI-LEEGSSVNMTCLSQGFPAPKILW---SRQLPNGELQPL 558
L + AP V P + + G V + C + G P P I W + L
Sbjct: 4301 VILVLQSAP---VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRT 4357
Query: 559 SENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPK 601
+ +L L + + D+G Y C N G + L+++ P+
Sbjct: 4358 LPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQ 4400
Score = 82.4 bits (202), Expect = 1e-15
Identities = 143/686 (20%), Positives = 255/686 (37%), Gaps = 71/686 (10%)
Query: 28 ETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSF 87
E + + + + +SL C SP +W +P + T + ++
Sbjct: 2544 EDSADEEVTVTVNNPISLICEALAFPSPNITWMKD-GAPFEASRNIQLLPGTHGLQILNA 2602
Query: 88 GNEHS--YLCTATCESRKLEKGIQVEIY---SFPKDPEIHLSGPLEA----GKPITVKC- 137
E + Y C T E + K VE+ S KD + G E +T++C
Sbjct: 2603 QKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECE 2662
Query: 138 SVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRA 197
S A P R D G + S + + L+ + +V+ D G+ L
Sbjct: 2663 SWAVPPPTIRWYKD---GQPVTPSSRLQVLGEGRLLQIQPTQVS------DSGRYLCVAT 2713
Query: 198 KLH-IDEMD-----SVPTVRQAVKEL----QVYISPKNTVISVNPSTKLQEGGSVTMTCS 247
+ D+ D VP + Q V + ++ + V ++ E + C
Sbjct: 2714 NVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCD 2773
Query: 248 SEGLPAPEIFWSKK---LDNGN-LQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKE 303
+ +P P++ W ++ L G+ + L G L + +R E++G Y C+ N +G++
Sbjct: 2774 TNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLH 2833
Query: 304 VELIVQEKPFTVEISPG--PRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRS 361
EL+V P + + + +V L C +G P+ SW Q P S R
Sbjct: 2834 YELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISW-LQNGLPFSPSPRL 2892
Query: 362 E--GTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDP--EIEMSGGLVN 417
+ L +S + SY+C EK + + PR ++E ++N
Sbjct: 2893 QVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILN 2952
Query: 418 GSSVTVSCKVPSVYPLDRLEIELLKGETIL---ENIEFLEDTDMKSLENKSLEMTFIPTI 474
SSV++ C V+ E+ K L E + L T L L + + T
Sbjct: 2953 -SSVSLPC---DVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTC 3008
Query: 475 EDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTC 534
E A Q + + + P RQ+ + P+D ++ G ++C
Sbjct: 3009 EALNAAGRDQKLVQLSVL-VPPAFRQAPR------GPQDAV-------LVRVGDKAVLSC 3054
Query: 535 LSQGFPAPKILWSRQ----LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRK 590
+ P P + W + + Q L L + ++ D G+Y C+ N AG + +
Sbjct: 3055 ETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVR 3114
Query: 591 EVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWIILKKKAETGDT-VL 646
L +QV P + + S G ++++C VP TW+ + E+ +
Sbjct: 3115 TFTLTVQV-PPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGV 3173
Query: 647 KSIDGAYTIRKAQLKDAGVYECESKN 672
S G + + Q AG Y C ++N
Sbjct: 3174 VSRGGRLQLSRLQPAQAGTYTCVAEN 3199
Score = 82.0 bits (201), Expect = 2e-15
Identities = 138/688 (20%), Positives = 257/688 (37%), Gaps = 75/688 (10%)
Query: 44 SLTCSTTGCESPFFSWRTQ---IDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCE 100
+L C+ TG P +W + + L ++ N+G +L + + Y C A
Sbjct: 2277 TLECNATGKPPPTVTWERDGQPVGAELGLQLQNQG--QSLHVERAQAAHTGRYSCVAENL 2334
Query: 101 SRKLEKGIQVEIYSFPK-----DPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKG 155
+ + E+ ++ + P+ DP +++ L + P+T+ C + P
Sbjct: 2335 AGRAERKFELSVLVPPELIGDLDPLTNITAALHS--PLTLLCEAMGIPP---------PA 2383
Query: 156 DHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVK 215
+ +E + + L + T E + C A E +V
Sbjct: 2384 IRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSV----- 2438
Query: 216 ELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSK---KLDNGNLQHLSG 272
+V + P + K+ +G + + C+ G P P++ W K L G+ H+S
Sbjct: 2439 --EVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISP 2496
Query: 273 NAT-LTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTV---EISPGPRIAAQIG 328
+ L ++ + +G Y C N +G+ K +L V P + E S + +
Sbjct: 2497 DGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVN 2556
Query: 329 DSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHS--YLCTVT 386
+ + L C + SP+ +W +P + T L ++ + E + Y C VT
Sbjct: 2557 NPISLICEALAFPSPNITWMKD-GAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVT 2615
Query: 387 CGHKKLEKGIQVELYSFPR----DPEIEMSGGLVN---GSSVTVSCKVPSVYPLDRLEIE 439
+ K VE+ P DP E+ V S++T+ C+ +V P +
Sbjct: 2616 NELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYK 2675
Query: 440 LLKGETILENIEFLEDTDMKSLENKSLEMTFIPT-IEDTGKAL-VCQAKLHIDDMEFEPK 497
+ T ++ L + + ++ PT + D+G+ L V DD +F
Sbjct: 2676 DGQPVTPSSRLQVLGEGRLLQIQ---------PTQVSDSGRYLCVATNVAGEDDQDFNVL 2726
Query: 498 -------QRQSTQTLYVNVAPRDTTVL--VSPSSILEEGSSVNMTCLSQGFPAPKILWSR 548
Q+ + + R+ V+ + E + + C + P P + W R
Sbjct: 2727 IQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYR 2786
Query: 549 Q----LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIK 604
+ E+ L L + + E++G Y C+ N+ G EL++ P +
Sbjct: 2787 EDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILG 2846
Query: 605 LTAFPSESVKEGDTVIISCTC---GN-VPE-TWIILKKKAETGDTVLKSIDG-AYTIRKA 658
T E V + +S C GN VP +W+ + DG + A
Sbjct: 2847 DTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTA 2906
Query: 659 QLKDAGVYECESKNKVGSQLRSLTLDVQ 686
++ DA Y C ++N+ GS + TL VQ
Sbjct: 2907 EVADAASYMCVAENQAGSAEKLFTLRVQ 2934
Score = 78.6 bits (192), Expect = 2e-14
Identities = 113/497 (22%), Positives = 193/497 (38%), Gaps = 58/497 (11%)
Query: 217 LQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLD-----NGNLQHLS 271
L+V + P VN + + E SVT+ C + G+P P++ W K G +
Sbjct: 1880 LKVLVPPNIEPGPVNKA--VLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVD 1937
Query: 272 GNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKP-FTVEIS-PGPRIAAQIGD 329
G L + ++ D+G Y C N+ G L V P T+ S PGP + +
Sbjct: 1938 GR-VLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVL---VNT 1993
Query: 330 SVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGT--------NSTLTLSPVSFENEHSY 381
V LTC+ G SP+ W V GT LTL+ + Y
Sbjct: 1994 PVRLTCNATGAPSPTLMWLKD-----GNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 2048
Query: 382 LCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELL 441
C + + + ++++ P E++ +V SV + C+ ++ P
Sbjct: 2049 SCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPP--------- 2099
Query: 442 KGETILENIEFLEDTDMKSLENK-SLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQ 500
+L + D + LE + + ++ + +A V A + + + +
Sbjct: 2100 ---PVLSWWK-----DGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSE 2151
Query: 501 STQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQ---LP--NGEL 555
L V VAP + S + + EG +++C +G P PKI W + LP L
Sbjct: 2152 KHYNLNVWVAP-VFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGL 2210
Query: 556 QPLSE-NATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSE-SV 613
Q +S L L ++ G Y CE N G S ++++L + V P+ P++ SV
Sbjct: 2211 QHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSV 2270
Query: 614 KEGDTVIISCTCGNVPETWIILKKK-----AETGDTVLKSIDGAYTIRKAQLKDAGVYEC 668
+ + C P + ++ AE G L++ + + +AQ G Y C
Sbjct: 2271 VQDGVATLECNATGKPPPTVTWERDGQPVGAELG-LQLQNQGQSLHVERAQAAHTGRYSC 2329
Query: 669 ESKNKVGSQLRSLTLDV 685
++N G R L V
Sbjct: 2330 VAENLAGRAERKFELSV 2346
Score = 76.6 bits (187), Expect = 8e-14
Identities = 159/750 (21%), Positives = 258/750 (34%), Gaps = 133/750 (17%)
Query: 15 LWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNE 74
+W++ + I T+ S++ +Q G V ++CS +G +P SW + + +
Sbjct: 600 VWLLVREAPQVSIHTS--SQHFSQ-GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHV 656
Query: 75 GTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPIT 134
TL + V+ + +Y C AT E ++ + + P ++ + G+
Sbjct: 657 DAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAV 716
Query: 135 VKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLV 194
+ C + V P R LE+ P GK+ +
Sbjct: 717 LVCEASGVPP------------------------PRVIWYRGGLEMILAPEGSSSGKLRI 752
Query: 195 CRAKLHIDEMDSVPTVRQAVKEL-------QVYISPKNTVISVNPSTKLQEGGSVTMTCS 247
A+ E D+ +AV EL Q+ + + + ++ G S + C
Sbjct: 753 PAAQ----ERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACR 808
Query: 248 SEGLPAPEIFWSK----------KLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLI 297
+ G P P + W + G+ + L ++ ED YVCE N+
Sbjct: 809 ATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVF 868
Query: 298 GKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVM-GCESPSFSWRTQIDSPLS 356
GK + E LIV S P + G V L C V+ G P W
Sbjct: 869 GKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPP 928
Query: 357 GKVRSEGTNSTLTLSPVSFENEHSYLCTVT----CGHKKLEKGIQVELYSFPRDPEIEMS 412
G S + +L L E+ Y C T H+ +E +QV P +
Sbjct: 929 GSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITN 988
Query: 413 GGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFI- 471
G V S V+ VP+ TI E T N S E T +
Sbjct: 989 EG-VPASLPCVASGVPA--------------PTITWTKETNALTSRGPHYNVSKEGTLLI 1033
Query: 472 --PTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSI----LE 525
P+ +D G A VC A + E R S L ++ + L+ S+ ++
Sbjct: 1034 AQPSAQDAG-AYVCTATNTVGFSSQE--MRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQ 1090
Query: 526 EGSSVNMTCLS-------------------QGFPAPKIL--------------------- 545
G S + C + Q P P++L
Sbjct: 1091 VGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQ 1150
Query: 546 --WSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPK-D 602
WS+ LQ ++ + + D+G Y CE N AG EVEL + P
Sbjct: 1151 LSWSKD--GVVLQGRGPQGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWG 1208
Query: 603 IKLTAFPSESVKEGDTVIISCTCGNVPETWIILKK-------KAETGDTVLKSIDGAYTI 655
T+ E V G+ + C P+ + +K + G VL+ +G+ +
Sbjct: 1209 ADETSGLLERV-AGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLE--EGSLFL 1265
Query: 656 RKAQLKDAGVYECESKNKVGSQLRSLTLDV 685
D+G YEC++ N+VGS R L V
Sbjct: 1266 ASVSPADSGDYECQATNEVGSTSRRAKLVV 1295
Score = 74.7 bits (182), Expect = 3e-13
Identities = 104/505 (20%), Positives = 184/505 (36%), Gaps = 50/505 (9%)
Query: 216 ELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDN----------- 264
+L VY+ P + G S+T+ C + G P PEI W K
Sbjct: 1292 KLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYG 1351
Query: 265 --------GNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVE 316
G + L +L ++ DSG+Y C N G +++ L+V P +
Sbjct: 1352 WDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLG 1411
Query: 317 ISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSG----KVRSEGTNSTLTLSP 372
+ G V L C G +P W L G +V+ +G +T S
Sbjct: 1412 AGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSH 1471
Query: 373 VSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYP 432
V +E Y C + + Q+ +++ P + GS+ T V
Sbjct: 1472 VG--DEGRYQCVAFSPAGQQARDFQLRVHAPPT----------IWGSNETGEVAVME--- 1516
Query: 433 LDRLEIELLKGETI-LENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDD 491
D L L + + NI + +D + K + ++ G+A A ++
Sbjct: 1517 -DHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQ-LGRAQSSDAGVYTCK 1574
Query: 492 MEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILE-EGSSVNMTCLSQGFPAPKILWSRQ- 549
+ L V V P P + G V + C+++G P+P + W +
Sbjct: 1575 ASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEG 1634
Query: 550 LP---NGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLT 606
LP + E + ++ + L L S SG+Y C + AG + + + +QV P+ +
Sbjct: 1635 LPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAE 1694
Query: 607 AFPSESVKEGDTVIISCTCGNVPE---TWIILKKKAETGDTVLKSIDG-AYTIRKAQLKD 662
+ G + + C P W+ + AE V + G I +L
Sbjct: 1695 GLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDH 1754
Query: 663 AGVYECESKNKVGSQLRSLTLDVQG 687
+G++ C++ N+ G+ + + V G
Sbjct: 1755 SGLFACQATNEAGTAGAEVEVSVHG 1779
Score = 73.9 bits (180), Expect = 5e-13
Identities = 159/749 (21%), Positives = 272/749 (36%), Gaps = 109/749 (14%)
Query: 17 IMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLN-------G 69
I A A ++ P ++G S L C TG P +WR PL G
Sbjct: 778 IQLAVGHAPQLTELPRD-VTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRG 836
Query: 70 KVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVE---IYSFPKDPEIHLSGP 126
+ + + L V+ ++ Y+C E+R + +Q E I + P+I S P
Sbjct: 837 SRSRQPDSGVLFFESVAPEDQAPYVC----EARNVFGKVQAEARLIVTGHAPPQIASSAP 892
Query: 127 ---------------LEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLED-ADR 170
+ AG+P+ + + D P ++ D + L++ A R
Sbjct: 893 TVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGR 952
Query: 171 KSL---ETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMD---SVPTVRQAV--------KE 216
S T + ++ + + A HI S+P V V KE
Sbjct: 953 YSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKE 1012
Query: 217 LQVY--------ISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWS-KKLDNGNL 267
+S + T++ PS + G V ++ G + E+ S +L
Sbjct: 1013 TNALTSRGPHYNVSKEGTLLIAQPSAQ-DAGAYVCTATNTVGFSSQEMRLSVNRLALSKY 1071
Query: 268 ----QHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRI 323
L + +L L +++ DSG Y C N G L VQ P ++ PGPR+
Sbjct: 1072 VWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPP---QVQPGPRV 1128
Query: 324 -AAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYL 382
+G+++ L C G P SW S ++ G ++ + + + Y
Sbjct: 1129 LKVLVGEALDLNCVAEGNPEPQLSW-----SKDGVVLQGRGPQGSVHFAAIRTSDAGRYR 1183
Query: 383 CTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGL--VNGSSVTVSCKVPSVYPLDRLEIEL 440
C + +++ + P E SG L V G + ++ C + ++
Sbjct: 1184 CEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGT---PKPQVTW 1240
Query: 441 LKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQ 500
KG + + + LE SL + + + D+G CQA E R+
Sbjct: 1241 RKGPS---SEPLHGQPGVAVLEEGSLFLASV-SPADSGD-YECQA-----TNEVGSTSRR 1290
Query: 501 STQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSR--QLPN------ 552
+ +YV + R+ + S + G S+ + C + GFP P+I+W + QL
Sbjct: 1291 AKLVVYVPPSIREDGRKANVSGM--AGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWA 1348
Query: 553 -----------GELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPK 601
G + L E +L + DSG+Y C NQAG ++++ L++ P
Sbjct: 1349 GYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPS 1408
Query: 602 DIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAET----GDTVLKSIDG-AYTIR 656
+ A G V + C VP + K + G + DG I
Sbjct: 1409 VLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRIT 1468
Query: 657 KAQLKDAGVYECESKNKVGSQLRSLTLDV 685
+ + D G Y+C + + G Q R L V
Sbjct: 1469 GSHVGDEGRYQCVAFSPAGQQARDFQLRV 1497
Score = 68.2 bits (165), Expect = 3e-11
Identities = 152/728 (20%), Positives = 260/728 (35%), Gaps = 95/728 (13%)
Query: 36 LAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNG----KVTNEGTTSTLTMNPVSFGNEH 91
L G V L C T+G +P W L G +V +G +T + V G+E
Sbjct: 1419 LGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHV--GDEG 1476
Query: 92 SYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEID 151
Y C A + + + Q+ +++ P + G E G+ ++ D L +
Sbjct: 1477 RYQCVAFSPAGQQARDFQLRVHAPPT-----IWGSNETGEVAVME---------DHL-VQ 1521
Query: 152 LLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIE--DIGKVLVCRAKLHIDEMDSVPT 209
LL + + D L T S +V +T +G+ A ++ + +
Sbjct: 1522 LLCEARGVPTPNITWFKDGALLPT-STKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVG 1580
Query: 210 VRQAVKELQVYISPKNTVISVNP-STKLQEGGSVTMTCSSEGLPAPEIFWSKK----LDN 264
+ L VY+ P P K G V + C + G P+P + W + ++
Sbjct: 1581 AAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAES 1640
Query: 265 GNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIA 324
+ + + L L + SG+Y C + G+ + + VQ P + ++
Sbjct: 1641 NESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVT 1700
Query: 325 AQIGDSVMLTCSVMGCESPSFSW--RTQIDSPLSG-KVRSEGTNSTLTLSPVSFENEHSY 381
+G + L C G P+ W + L+G +V S+GT TL + V ++ +
Sbjct: 1701 TIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGT--TLHIDHVELDHSGLF 1758
Query: 382 LCTVT--CGHKKLEKGIQVELYSFPRDPEI---EMSGGLVNGSSVTVSCKVP-----SVY 431
C T G E + V P E+ + G + SS +C P +
Sbjct: 1759 ACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAH 1818
Query: 432 PLDRL-----EIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAK 486
P L L GE + + ++ +E L I T T L ++K
Sbjct: 1819 PKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQ-IEKVDLRDEGIYTCAATN--LAGESK 1875
Query: 487 LHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILW 546
+ P + P + VL + S LE CL+ G P P + W
Sbjct: 1876 REVALKVLVPPN--------IEPGPVNKAVLENASVTLE--------CLASGVPPPDVSW 1919
Query: 547 SRQLPNGELQPLS---------ENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQ 597
+ QP+S + L + ++ D+G Y C N AG + L +
Sbjct: 1920 FK-----GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVN 1974
Query: 598 VTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKK----AETGDTVLKSIDG-- 651
V P+ + P V V ++C P ++ K + G L+ G
Sbjct: 1975 VPPRITLPPSLPG-PVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGR 2033
Query: 652 AYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ------GRENNKDYFSPELLVLYFA 705
T+ A+ D+G Y C + + VG + + L V G E N + E + L
Sbjct: 2034 VLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQ 2093
Query: 706 SSLIIPAI 713
S + P +
Sbjct: 2094 SHAMPPPV 2101
Score = 50.4 bits (119), Expect = 6e-06
Identities = 75/305 (24%), Positives = 120/305 (39%), Gaps = 59/305 (19%)
Query: 29 TTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFG 88
T P R L ++GD + L C+ G +P W T D P+ V+ + STL VS
Sbjct: 4133 TLPGDRSL-RLGDRLWLRCAARGSPTPRIGW-TVNDRPVTEGVSEQDGGSTLQRAAVSRE 4190
Query: 89 NEHSYLCTATCESR------------KLEKGIQVEIYSFPKDPEIHLSGPLEA-----GK 131
+ +Y+C A E+R K +Q E +S+ +P + G ++ G
Sbjct: 4191 DSGTYVCWA--ENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEP---VGGSIQLDCVVRGD 4245
Query: 132 PITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGK 191
P+ + D P L+G HL R L+ SL + T +D G+
Sbjct: 4246 PVPDIHWIKDGLP--------LRGSHL-----------RHQLQNGSLTIHRTER-DDAGR 4285
Query: 192 VLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTK-LQEGGSVTMTCSSEG 250
C A+ +EM K++ + + V V P ++ G V + C + G
Sbjct: 4286 YQ-CLAE---NEMG-------VAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATG 4334
Query: 251 LPAPEIFW---SKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELI 307
P P I W + L + +L L + D+G Y C NL+G L+
Sbjct: 4335 EPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLV 4394
Query: 308 VQEKP 312
V+ +P
Sbjct: 4395 VRGEP 4399
>gi|139948432 adlican [Homo sapiens]
Length = 2828
Score = 112 bits (280), Expect = 1e-24
Identities = 168/723 (23%), Positives = 294/723 (40%), Gaps = 110/723 (15%)
Query: 39 IGDSVSLTCSTTGCESPFFSW------RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHS 92
+GD++++ C G +P SW Q SP+ G++T TL++ SF +
Sbjct: 1964 LGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLH-ENRTLSIKEASFSDRGV 2022
Query: 93 YLCTATCESRKLEKGIQVEIYSFPKDPEIHLSG----PLEAGKPITVKCSVADVYPFDRL 148
Y C A+ + I++ + + P P IH L G I + C+ A P +
Sbjct: 2023 YKCVASNAAGADSLAIRLHVAALP--PVIHQEKLENISLPPGLSIHIHCT-AKAAPLPSV 2079
Query: 149 EIDLLKGDHLMKSQEFLED----ADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEM 204
L G + SQ FL +L ++L +D G+ A L
Sbjct: 2080 RWVLGDGTQIRPSQ-FLHGNLFVFPNGTLYIRNL------APKDSGRYECVAANL----- 2127
Query: 205 DSVPTVRQAVKELQVYISPKNT-VISVNP-STKLQEGGSVTMTCSSEGLPAPEIFW---S 259
V + R+ V +L V + N + +P T ++ GG++ + CS+ G P P I W S
Sbjct: 2128 --VGSARRTV-QLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPS 2184
Query: 260 KKLDNGNLQHLS-----GNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFT 314
K++ + S N TL + ++ +D+G Y+C N +G + +++ V KP
Sbjct: 2185 KRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAK 2244
Query: 315 VEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGT---------- 364
+E G + + C G +P SW S ++ ++S+ +
Sbjct: 2245 IEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVF 2304
Query: 365 -NSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRD--PEIEMSGGLVNGSSV 421
N TL + V E Y C K E ++V++ + P + ++ + G V
Sbjct: 2305 NNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVV 2364
Query: 422 TVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKAL 481
TV+C+ KGE + + +L T+ K + S + I G L
Sbjct: 2365 TVACEA--------------KGEP-MPKVTWLSPTN-KVIPTSSEKY----QIYQDGTLL 2404
Query: 482 VCQAKLHIDDMEFEPKQRQS------TQTLYVNVAPRDTTVLVSPSSILEE----GSSVN 531
+ +A+ D + R S T ++VNV P +P + + E GS
Sbjct: 2405 IQKAQ-RSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKL 2463
Query: 532 MTCLSQGFPAPKILWSRQLPNGELQP---------LSENATLTLISTKMEDSGVYLCEGI 582
+ C ++G P P++LW+ P G + P + N +L + S + DS +C
Sbjct: 2464 IDCKAEGIPTPRVLWA--FPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMAR 2521
Query: 583 NQAGRSRKEVELIIQVTPKDIKLTAFP-SESV--KEGDTVIISCTCGNVPE---TWIILK 636
N+ G +R ++L + + P + + P SE + G T+ ++C+ P W++
Sbjct: 2522 NEGGEARLILQLTV-LEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPN 2580
Query: 637 -KKAETGDTVLK---SIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGR-ENN 691
++G + + DG I DAG Y C ++N G R ++L V + E N
Sbjct: 2581 GTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEAN 2640
Query: 692 KDY 694
K Y
Sbjct: 2641 KQY 2643
Score = 90.9 bits (224), Expect = 4e-18
Identities = 119/561 (21%), Positives = 202/561 (36%), Gaps = 106/561 (18%)
Query: 186 IEDIGKVLVCRAKLH-IDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTM 244
++D G+ + + LH +D M V L V + + S + G ++ M
Sbjct: 1920 VQDRGQYMCTASNLHGLDRM---------VVLLSVTVQQPQILASHYQDVTVYLGDTIAM 1970
Query: 245 TCSSEGLPAPEIFW---------SKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVN 295
C ++G PAP+I W + G + L N TL++ D G+Y C N
Sbjct: 1971 ECLAKGTPAPQISWIFPDRRVWQTVSPVEGRIT-LHENRTLSIKEASFSDRGVYKCVASN 2029
Query: 296 LIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPL 355
G + + L V P + I+ G S+ + C+ PS W + +
Sbjct: 2030 AAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQI 2089
Query: 356 SGKVRSEGT-----NSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELY--------- 401
G N TL + ++ ++ Y C + +Q+ +
Sbjct: 2090 RPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARIT 2149
Query: 402 -SFPRDPEIEMSGGLVNGSSVT------VSCKVPSVYPLDRLEIELLKGETILENIEFLE 454
+ PR ++ G L S + + ++PS +D L F
Sbjct: 2150 GTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDAL---------------FSF 2194
Query: 455 DTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDT 514
D+ +K N +L + + T +D G L C A+ + D +
Sbjct: 2195 DSRIKVFANGTLVVKSV-TDKDAGDYL-CVARNKVGD----------------DYVVLKV 2236
Query: 515 TVLVSPSSILEE---------GSSVNMTCLSQGFPAPKILWSRQLPNGEL---------- 555
V++ P+ I + G + + C++ G P P+I WS LP+G L
Sbjct: 2237 DVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWS--LPDGSLVNSFMQSDDS 2294
Query: 556 ------QPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFP 609
+ N TL M + G Y C NQ G+ V + + P I+ +
Sbjct: 2295 GGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYL 2354
Query: 610 SESVKEGDTVIISCTCGNVP---ETWIILKKKAETGDTVLKSI--DGAYTIRKAQLKDAG 664
+ V GD V ++C P TW+ K + I DG I+KAQ D+G
Sbjct: 2355 AVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSG 2414
Query: 665 VYECESKNKVGSQLRSLTLDV 685
Y C +N G +++ + V
Sbjct: 2415 NYTCLVRNSAGEDRKTVWIHV 2435
Score = 88.6 bits (218), Expect = 2e-17
Identities = 139/617 (22%), Positives = 230/617 (37%), Gaps = 91/617 (14%)
Query: 26 KIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGT--------- 76
KIE E+ + G + + C TG +P SW S +N + ++ +
Sbjct: 2244 KIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVV 2303
Query: 77 --TSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKD--PEIHLSGPLEAGKP 132
TL N V E Y C A + K E ++V++ + P + +L+ + G
Sbjct: 2304 FNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDV 2363
Query: 133 ITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKV 192
+TV C KG+ + K K + T S + I G +
Sbjct: 2364 VTVACEA--------------KGEPMPKVTWL--SPTNKVIPTSSEKYQ----IYQDGTL 2403
Query: 193 LVCRAKLHIDEMDSVPTVRQAVKE------LQVYISPKNTVISVNPSTKLQE----GGSV 242
L+ +A+ D + VR + E + V + P + NP T ++E G
Sbjct: 2404 LIQKAQ-RSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRK 2462
Query: 243 TMTCSSEGLPAPEIFWSKKLD-------NGNLQHLSGNATLTLIAMRMEDSGIYVCEGVN 295
+ C +EG+P P + W+ GN + GN +L + ++R DS VC N
Sbjct: 2463 LIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARN 2522
Query: 296 LIGKNRKEVELIVQEKPFTVEISPGP---RIAAQIGDSVMLTCSVMGCESPSFSW----R 348
G+ R ++L V E P I P +I A G ++ L CS G +PS W
Sbjct: 2523 EGGEARLILQLTVLE-PMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNG 2581
Query: 349 TQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTV--TCGHKKLEKGIQVELYSFPRD 406
T + S + + L +S +S + +Y C GH + ++V L +
Sbjct: 2582 TDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKP-EAN 2640
Query: 407 PEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSL 466
+ ++NG ++ + C P R L G LE + L + L+N +L
Sbjct: 2641 KQYHNLVSIINGETLKLPCTPPGA-GQGRFSWTLPNG-MHLEGPQTLGRVSL--LDNGTL 2696
Query: 467 EMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEE 526
+ +A V ++ ME E ++ + V P T +P
Sbjct: 2697 TVR---------EASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRP 2747
Query: 527 GSSVNMTCLSQGFPAPKILW-------------SRQLPNGELQPLSENATLTLISTKMED 573
G++V + C++ G P I W +R N L P +LT+ D
Sbjct: 2748 GNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHP---QGSLTIQHATQRD 2804
Query: 574 SGVYLCEGINQAGRSRK 590
+G Y C N G K
Sbjct: 2805 AGFYKCMAKNILGSDSK 2821
Score = 86.3 bits (212), Expect = 9e-17
Identities = 112/528 (21%), Positives = 210/528 (39%), Gaps = 67/528 (12%)
Query: 221 ISPKNTVISVNPSTKLQEGGSVTM-TCSSEGLPAPEIFWSK------KLDNGNLQHLS-- 271
+ K +++ +P T + T+ C + G P P + W+K N +Q
Sbjct: 1849 LGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVL 1908
Query: 272 GNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSV 331
N TL + ++++D G Y+C NL G +R V L V + + S + +GD++
Sbjct: 1909 KNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTI 1968
Query: 332 MLTCSVMGCESPSFSW------RTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTV 385
+ C G +P SW Q SP+ G++ N TL++ SF + Y C
Sbjct: 1969 AMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLH-ENRTLSIKEASFSDRGVYKCVA 2027
Query: 386 TCGHKKLEKGIQVELYSFPRDPEIEMSG----GLVNGSSVTVSCKVPSVYPLDRLEIELL 441
+ I++ + + P P I L G S+ + C + PL + L
Sbjct: 2028 SNAAGADSLAIRLHVAALP--PVIHQEKLENISLPPGLSIHIHCTAKAA-PLPSVRWVLG 2084
Query: 442 KGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPK---Q 498
G T + +FL ++ N +L + + +D+G+ C A + + Q
Sbjct: 2085 DG-TQIRPSQFLHG-NLFVFPNGTLYIRNLAP-KDSGR-YECVAANLVGSARRTVQLNVQ 2140
Query: 499 RQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGEL--- 555
R + +PR T V G ++ + C + G P P+ILW +LP+ +
Sbjct: 2141 RAAANARITGTSPRRTDV--------RYGGTLKLDCSASGDPWPRILW--RLPSKRMIDA 2190
Query: 556 -------QPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAF 608
+ N TL + S +D+G YLC N+ G +++ + + P I+
Sbjct: 2191 LFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEE 2250
Query: 609 PSESVKEGDTVIISCTCGNVPE---TWII--------LKKKAETGDTVLKSI---DGAYT 654
V G + + C +P +W + + ++G + + +G
Sbjct: 2251 NDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLY 2310
Query: 655 IRKAQLKDAGVYECESKNKVGS---QLRSLTLDVQGRENNKDYFSPEL 699
+ +++ G Y C ++N+VG ++R + NK Y + ++
Sbjct: 2311 FNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQV 2358
Score = 81.3 bits (199), Expect = 3e-15
Identities = 112/484 (23%), Positives = 197/484 (40%), Gaps = 54/484 (11%)
Query: 239 GGSVTMTCSSEGLPAPEIFWSKKLD-----NGNLQHLSGNATLTLIAMRMEDSGIYVCEG 293
G VT+ C ++G P P++ W + + + + TL + + DSG Y C
Sbjct: 2361 GDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLV 2420
Query: 294 VNLIGKNRKEVELIVQEKPFTVEISPGP----RIAAQIGDSVMLTCSVMGCESPSFSWR- 348
N G++RK V + V +P + +P P R A G ++ C G +P W
Sbjct: 2421 RNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAF 2480
Query: 349 ---TQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTC--GHKKLEKGIQV-ELYS 402
+ +P G + N +L + + + +C G +L + V E
Sbjct: 2481 PEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPME 2540
Query: 403 FP--RDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKS 460
P DP E + G +++++C P L + +L T L++ + L+ K+
Sbjct: 2541 KPIFHDPISEKITAMA-GHTISLNCSAAGT-PTPSL-VWVLPNGTDLQSGQQLQRFYHKA 2597
Query: 461 LENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSP 520
+ L ++ + ++ D G A C A+ E +L V + P +
Sbjct: 2598 --DGMLHISGLSSV-DAG-AYRCVARNAAGHTE-------RLVSLKVGLKPEANKQYHNL 2646
Query: 521 SSILEEGSSVNMTCLSQGFPAPKILWSRQLPNG-ELQ--------PLSENATLTLISTKM 571
SI+ G ++ + C G + W+ LPNG L+ L +N TLT+ +
Sbjct: 2647 VSIIN-GETLKLPCTPPGAGQGRFSWT--LPNGMHLEGPQTLGRVSLLDNGTLTVREASV 2703
Query: 572 EDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE- 630
D G Y+C + G S + +I+ P I P + G+TV ++C +P+
Sbjct: 2704 FDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKA 2763
Query: 631 --TWIILKK-------KAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSL 681
TW + K +A G+ TI+ A +DAG Y+C +KN +GS ++
Sbjct: 2764 DITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTT 2823
Query: 682 TLDV 685
+ V
Sbjct: 2824 YIHV 2827
Score = 62.0 bits (149), Expect = 2e-09
Identities = 57/218 (26%), Positives = 94/218 (43%), Gaps = 29/218 (13%)
Query: 524 LEEGSSVNMTCLSQGFPAPKILW---------SRQLPNGELQPLSENATLTLISTKMEDS 574
L G S+++ C ++ P P + W Q +G L + N TL + + +DS
Sbjct: 2059 LPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLF-VFPNGTLYIRNLAPKDS 2117
Query: 575 GVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSE--SVKEGDTVIISCTCGNVPETW 632
G Y C N G +R+ V+L +Q + ++T V+ G T+ + C+ P
Sbjct: 2118 GRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPR 2177
Query: 633 IILKKKAETGDTVLKSID--------GAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLD 684
I+ + ++ L S D G ++ KDAG Y C ++NKVG L +D
Sbjct: 2178 ILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVD 2237
Query: 685 V-------QGRENN--KDYFSPELLVLYFASSLIIPAI 713
V + +E N K ++ +L V A+ L P I
Sbjct: 2238 VVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEI 2275
Score = 45.1 bits (105), Expect = 2e-04
Identities = 47/202 (23%), Positives = 83/202 (41%), Gaps = 35/202 (17%)
Query: 499 RQSTQTLYVNVAP-----RDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNG 553
RQ+ +V + P RD TVL EG ++C + +P I W LP+G
Sbjct: 469 RQARGRSWVMIEPSGAVQRDQTVL--------EGGPCQLSCNVKASESPSIFWV--LPDG 518
Query: 554 EL--QPLSE---------NATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKD 602
+ P+ + + L + S + DSG+Y C + R +++Q
Sbjct: 519 SILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQ 578
Query: 603 IKLTAFPSESVKEGDTVIISCTCGNVPE---TWIILKKK-----AETGDTVLKSIDGAYT 654
+ G++V + C +PE +WI+ ++ A T + +G +
Sbjct: 579 PAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLP-NGTLS 637
Query: 655 IRKAQLKDAGVYECESKNKVGS 676
I K Q+ D+G Y C + N+ G+
Sbjct: 638 IPKVQVSDSGYYRCVAVNQQGA 659
Score = 42.7 bits (99), Expect = 0.001
Identities = 44/162 (27%), Positives = 72/162 (44%), Gaps = 23/162 (14%)
Query: 173 LETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTV-ISVN 231
L KS+E + + + + I +V DEMD + R V+ + K+TV I N
Sbjct: 540 LRIKSMEPSDSGLYQCIAQVR--------DEMDRM-VYRVLVQSPSTQPAEKDTVTIGKN 590
Query: 232 PSTKLQEGGSVTMTCSSEGLPAPEIFWS-------KKLDNGNLQHLSGNATLTLIAMRME 284
P G SVT+ C++ +P + W L N + ++ N TL++ +++
Sbjct: 591 P------GESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVS 644
Query: 285 DSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQ 326
DSG Y C VN G + V + V +K + G R A+
Sbjct: 645 DSGYYRCVAVNQQGADHFTVGITVTKKGSGLPSKRGRRPGAK 686
Score = 40.8 bits (94), Expect = 0.005
Identities = 77/397 (19%), Positives = 140/397 (35%), Gaps = 46/397 (11%)
Query: 30 TPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPV---- 85
+P+ Y +I +TC ESP R++ + + G+ L +
Sbjct: 258 SPKKLYKHEIHKLKDMTCLKPSIESPLRQNRSRSIEEEQEQEEDGGSQLILEKFQLPQWS 317
Query: 86 ---SFGNEHSYLCTATCESRKLEKGIQVEI-YSFPKDPEIHLSGPLEAGKPIT----VKC 137
+ +EH + C+ +K ++ + + P D +I+ + L+ P+T K
Sbjct: 318 ISLNMTDEHGNMVNLVCDIKKPMDVYKIHLNQTDPPDIDINATVALDFECPMTRENYEKL 377
Query: 138 SVADVYPFD---RLEIDLLKGDHLMKSQEFLEDADRKSLETKSL--------EVTFTPVI 186
Y + +L +L+ S ++ +DAD ++L + E P I
Sbjct: 378 WKLIAYYSEVPVKLHRELMLSKDPRVSYQYRQDADEEALYYTGVRAQILAEPEWVMQPSI 437
Query: 187 E-------DIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEG 239
+ K ++ + S RQA V I P +V + EG
Sbjct: 438 DIQLNRRQSTAKKVLLSYYTQYSQTISTKDTRQARGRSWVMIEPSG---AVQRDQTVLEG 494
Query: 240 GSVTMTCSSEGLPAPEIFW---------SKKLDNGNLQHLSGNATLTLIAMRMEDSGIYV 290
G ++C+ + +P IFW + D + + + L + +M DSG+Y
Sbjct: 495 GPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQ 554
Query: 291 CEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSW--- 347
C +R ++VQ I G+SV L C+ + SW
Sbjct: 555 CIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILP 614
Query: 348 -RTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLC 383
R I+ + N TL++ V + Y C
Sbjct: 615 NRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRC 651
Score = 34.3 bits (77), Expect = 0.43
Identities = 20/77 (25%), Positives = 31/77 (40%), Gaps = 7/77 (9%)
Query: 527 GSSVNMTCLSQGFPAPKILWS-------RQLPNGELQPLSENATLTLISTKMEDSGVYLC 579
G SV + C + P + W L N + N TL++ ++ DSG Y C
Sbjct: 592 GESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRC 651
Query: 580 EGINQAGRSRKEVELII 596
+NQ G V + +
Sbjct: 652 VAVNQQGADHFTVGITV 668
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 110 bits (275), Expect = 5e-24
Identities = 115/493 (23%), Positives = 193/493 (39%), Gaps = 67/493 (13%)
Query: 236 LQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVN 295
++ G + T+ CS+ G PAP I WSK QH TL + + +DSG Y+C +
Sbjct: 3223 VEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATS 3282
Query: 296 LIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPL 355
G + L V+ P+ + + Q G++V L C G +F W +++ S L
Sbjct: 3283 PAGHAEATIILHVESPPYATTVPE--HASVQAGETVQLQCLAHGTPPLTFQW-SRVGSSL 3339
Query: 356 SGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRD--------- 406
G R+ N L + E+ Y C VT E Q+ + P
Sbjct: 3340 PG--RATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAG 3397
Query: 407 --PEIEMSGGLVN---GSSVTVSCKVPSVYPLDRLEI----ELLKGETILENIEFLEDTD 457
P ++++ L G+SV C VPS +L G ++ + + +++ D
Sbjct: 3398 STPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLD 3457
Query: 458 MKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVL 517
+S + T+I A+L I Q+ ++ +N+ TV+
Sbjct: 3458 ------QSCQGTYICQAHGPWGKAQASAQLVI----------QALPSVLINIRTSVQTVV 3501
Query: 518 VSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQP--LSENATLTLISTKMEDSG 575
V G +V CL+ G P P++ WS+ G L+P + + + ++ D+G
Sbjct: 3502 V--------GHAVEFECLALGDPKPQVTWSKV--GGHLRPGIVQSGGVVRIAHVELADAG 3551
Query: 576 VYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSE-SVKEGDTVIISCTCGNVPETWII 634
Y C N AG ++ V L++Q P+ + P E V G + C P I
Sbjct: 3552 QYRCTATNAAGTTQSHVLLLVQALPQ----ISMPQEVRVPAGSAAVFPCIASGYPTPDIS 3607
Query: 635 LKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDY 694
K + + + + + +DAG Y C + N+ G L V
Sbjct: 3608 WSKLDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQV--------- 3658
Query: 695 FSPELLVLYFASS 707
PE +V YF +
Sbjct: 3659 --PERVVPYFTQT 3669
Score = 101 bits (252), Expect = 2e-21
Identities = 118/502 (23%), Positives = 198/502 (39%), Gaps = 52/502 (10%)
Query: 210 VRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSK------KLD 263
V Q+V L V+ P +V+ P ++ G +VT+ C S G P W++ KL+
Sbjct: 3099 VAQSVVNLSVHGPPTVSVLPEGP-VWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLE 3157
Query: 264 NGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPG-PR 322
+ +A L + + + D+G YVC N +G +K+VE+IV T ++PG P+
Sbjct: 3158 QRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVD----TGAMAPGAPQ 3213
Query: 323 IAA-------QIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSF 375
+ A + G + L CS G +P+ W +++ SPL + R EG TL + V+
Sbjct: 3214 VQAEEAELTVEAGHTATLRCSATGSPAPTIHW-SKLRSPLPWQHRLEG--DTLIIPRVAQ 3270
Query: 376 ENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPL-- 433
++ Y+C T E I + + S P + + G +V + C PL
Sbjct: 3271 QDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTF 3330
Query: 434 --DRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDD 491
R+ L T + E ED+G+ C+ +
Sbjct: 3331 QWSRVGSSLPGRATARNELLHFERA----------------APEDSGR-YRCRVTNKVGS 3373
Query: 492 ME-FEPKQRQSTQ-TLYVNVAPRDTTVLVSPSSILEE---GSSVNMTCLSQGFPAPKILW 546
E F Q +L P +T V + LE G+SV C ++ W
Sbjct: 3374 AEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRW 3433
Query: 547 SRQLPNGELQP--LSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIK 604
++ G+L P ++ L + + G Y+C+ G+++ +L+IQ P +
Sbjct: 3434 FKE--GGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLI 3491
Query: 605 LTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAG 664
++V G V C P+ + K + G I +L DAG
Sbjct: 3492 NIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGIVQSGGVVRIAHVELADAG 3551
Query: 665 VYECESKNKVGSQLRSLTLDVQ 686
Y C + N G+ + L VQ
Sbjct: 3552 QYRCTATNAAGTTQSHVLLLVQ 3573
Score = 90.9 bits (224), Expect = 4e-18
Identities = 110/496 (22%), Positives = 211/496 (42%), Gaps = 52/496 (10%)
Query: 227 VISVNPSTKL-QEGGSVTMTCSSEGLPAPEIFWSKK----LDNGNLQHLSGNATLTLIAM 281
V+ V+P+ + +GGS ++ C G P +WS++ + +G Q G+ L ++
Sbjct: 1678 VVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSE-LHFPSV 1736
Query: 282 RMEDSGIYVCEGVNLIGKNRKEVELIVQE---KPFTVEISPGPRIAAQIGDSVMLTCSVM 338
+ D+G+Y+C NL N EL+V E KP TV + + + G V C+
Sbjct: 1737 QPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAK 1796
Query: 339 GCESPSFS--WRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGI 396
+SP+++ W + L R+ N LT+ V + +Y+CT + +++G
Sbjct: 1797 S-KSPAYTLVWTRLHNGKL--PTRAMDFNGILTIRNVQLSDAGTYVCTGS-NMFAMDQGT 1852
Query: 397 QVELYSFPRDPEIEMSGGLVNGSSVTVSCKVP--SVYPLDRLEIELLKGETILENIEFLE 454
++ SG L S+ VS P +V P E + +E+
Sbjct: 1853 AT--------LHVQASGTL---SAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTG 1901
Query: 455 DTDMKSLENKSLE--MTFIPTIEDTGKA-LVCQAKLHIDDMEFEPKQRQSTQTLYVN--V 509
+ + + +P +E T +A +C+A Q+ + L+V+
Sbjct: 1902 GPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRA-------HSSAGQQVARAVLHVHGGG 1954
Query: 510 APRDTTVLVSPS-SILEEGSSVNMTCLSQGFPAPKILWSRQ---LPNGELQPLSENATLT 565
PR V VSP + + G +V + C + G P+ I W ++ LP ++ ATL
Sbjct: 1955 GPR---VQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIATLL 2011
Query: 566 LISTKMEDSGVYLCEGINQAGRSRKEVELII----QVTPKDIKLTAFPSESVKEGDTVII 621
+ + D+G YLC + AG ++ +++++ +P +K+ + S SV EG T+ +
Sbjct: 2012 IPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIES-SSPSVTEGQTLDL 2070
Query: 622 SCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSL 681
+C + ++ + + + + D+G Y C +N G + S+
Sbjct: 2071 NCVVAGSAHAQVTWYRRGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASI 2130
Query: 682 TLDVQGRENNKDYFSP 697
T+ V ++ ++P
Sbjct: 2131 TVSVLHGTHSGPSYTP 2146
Score = 85.9 bits (211), Expect = 1e-16
Identities = 109/481 (22%), Positives = 177/481 (36%), Gaps = 55/481 (11%)
Query: 233 STKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCE 292
S+ + EG ++ + C G ++ W K+ + +H + + L L + DSG YVC
Sbjct: 2933 SSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCR 2992
Query: 293 GVNLIGKNRKEVELIVQEKPFTVEISPG----------------PRIAAQIGDSVMLTCS 336
+ G QE FTV + P P Q G C
Sbjct: 2993 AASGPGPE--------QEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCL 3044
Query: 337 VMGCESP-SFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKG 395
+ +P S W+T+ + L V S +T+ N +Y C + + +
Sbjct: 3045 IHDGAAPISLEWKTR-NQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSV 3103
Query: 396 IQVELYSFPRDPEIEMSGGLVN-GSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLE 454
+ + ++ P + V G +VT+ C V + P + I LE
Sbjct: 3104 VNLSVHGPPTVSVLPEGPVWVKVGKAVTLEC-VSAGEPRSSA-----RWTRISSTPAKLE 3157
Query: 455 DTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDT 514
+++ ++ D G VC A+ + + + + T + AP
Sbjct: 3158 QRTYGLMDSHAVLQISSAKPSDAG-TYVCLAQNALGTAQKQVEVIVDTGAM----APGAP 3212
Query: 515 TVLVSPSSI-LEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMED 573
V + + +E G + + C + G PAP I WS+ Q E TL + +D
Sbjct: 3213 QVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQD 3272
Query: 574 SGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWI 633
SG Y+C + AG + E +I+ V T SV+ G+TV + C P
Sbjct: 3273 SGQYICNATSPAGHA--EATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTF 3330
Query: 634 ILKKKAETGDTVLKSIDGAYTIR-------KAQLKDAGVYECESKNKVGSQLRSLTLDVQ 686
+ V S+ G T R +A +D+G Y C NKVGS L VQ
Sbjct: 3331 QWSR-------VGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQ 3383
Query: 687 G 687
G
Sbjct: 3384 G 3384
Score = 74.3 bits (181), Expect = 4e-13
Identities = 107/491 (21%), Positives = 180/491 (36%), Gaps = 51/491 (10%)
Query: 223 PKNTVISVNPSTKLQEGGSVTMTCSSEGL-PAPEIFWSKKLDNGNL--QHLSGNATLTLI 279
P + S ++ G VT C+++ PA + W++ L NG L + + N LT+
Sbjct: 1770 PITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTR-LHNGKLPTRAMDFNGILTIR 1828
Query: 280 AMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPF----TVEISPGPRIAAQIGDSVMLTC 335
+++ D+G YVC G N+ ++ L VQ V I P P++ Q G C
Sbjct: 1829 NVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHP-PQLTVQPGQLAEFRC 1887
Query: 336 SVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTV--TCGHKKLE 393
S G +P+ W L K + G L L V ++ YLC + G +
Sbjct: 1888 SATGSPTPTLEWTGGPGGQLPAKAQIHG--GILRLPAVEPTDQAQYLCRAHSSAGQQVAR 1945
Query: 394 KGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCK---VPSVYPLDRLEIELLKGETILENI 450
+ V PR + G +V + C+ VPS R E L + E
Sbjct: 1946 AVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSER- 2004
Query: 451 EFLEDTDMKSLENKSLEMTFIPTIEDTGKAL-VCQAKLHIDDMEFEPKQRQSTQTLYVNV 509
TD+ +L IP I +C A + R L +
Sbjct: 2005 -----TDIATL--------LIPAITTADAGFYLCVATSPAGTAQ----ARIQVVVLSASD 2047
Query: 510 APRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSE--NATLTLI 567
A + S S + EG ++++ C+ G ++ W R+ G L P ++ + L L
Sbjct: 2048 ASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRR--GGSLPPHTQVHGSRLRLP 2105
Query: 568 STKMEDSGVYLCEGINQAGRSRKEVEL-IIQVTPKDIKLTAFP-----------SESVKE 615
DSG Y+C N +G + + ++ T T P S V E
Sbjct: 2106 QVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAE 2165
Query: 616 GDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVG 675
G T+ ++C + K+ + ++ + + D+G Y C G
Sbjct: 2166 GQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSG 2225
Query: 676 SQLRSLTLDVQ 686
S+ + ++
Sbjct: 2226 PLEASVLVTIE 2236
Score = 74.3 bits (181), Expect = 4e-13
Identities = 142/697 (20%), Positives = 259/697 (37%), Gaps = 69/697 (9%)
Query: 26 KIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTT-STLTMNP 84
+++ +PE R G +V L C G S +WR + S L + +E T +TL +
Sbjct: 1957 RVQVSPE-RTQVHAGRTVRLYCRAAGVPSATITWRKEGGS-LPPQARSERTDIATLLIPA 2014
Query: 85 VSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYP 144
++ + YLC AT + + IQV + LS + P+ ++ S V
Sbjct: 2015 ITTADAGFYLCVATSPAGTAQARIQVVV----------LSASDASPPPVKIESSSPSVTE 2064
Query: 145 FDRLEIDLLKGDHLMKSQEFLEDADRKSLETK--SLEVTFTPVIEDIGKVLVCRAKLHID 202
L+++ + + T+ + V VCR +
Sbjct: 2065 GQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSG 2124
Query: 203 EMDSVPTVR--QAVKELQVY--ISPKNTVISVNPSTK-LQEGGSVTMTCSSEGLPAPEIF 257
++ TV Y + I + PS+ + EG ++ + C G ++
Sbjct: 2125 PKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVT 2184
Query: 258 WSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEI 317
W K+ + +H + + L L + DSG YVC V G V + ++ +
Sbjct: 2185 WHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIE-----ASV 2239
Query: 318 SPGPRIAAQI---------GDSVMLTCSVMGCESPSFSWRTQIDS-PLSGKVRSEGTNST 367
PGP +I G ++ L+C V G +W + S P +VR S
Sbjct: 2240 IPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRG----SR 2295
Query: 368 LTLSPVSFENEHSYLCTVTCGHKK----LEKGIQVELYSFPRDP----EIEMSGGLV-NG 418
L + S + Y+C + G + G Q ++P IE S V G
Sbjct: 2296 LYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEG 2355
Query: 419 SSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTG 478
++ ++C VP ++ K L ++ + SL + + D+G
Sbjct: 2356 QTLDLNCVVPGQ---SHAQVTWHKRGGSLP---------VRHQTHGSLLRLYQASPADSG 2403
Query: 479 KALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQG 538
+ VC+ +E + T + S SS + EG ++++ CL G
Sbjct: 2404 E-YVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAG 2462
Query: 539 FPAPKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQ- 597
++ W ++ + + + L L+ DSG Y+C + +G V + IQ
Sbjct: 2463 QAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQ 2522
Query: 598 -VTPKDIKLTAFP------SESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSID 650
++ + A+P S S+ G T+ ++C + I K+ + + + +
Sbjct: 2523 RLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVG 2582
Query: 651 GAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQG 687
I + D+G Y C N GS+ SL + +QG
Sbjct: 2583 SRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQG 2619
Score = 72.8 bits (177), Expect = 1e-12
Identities = 59/190 (31%), Positives = 90/190 (47%), Gaps = 15/190 (7%)
Query: 508 NVAPRDTTVLVSPS-SILEEGSSVNMTCLSQGFPAPKILWSRQ----LPNGELQPLSENA 562
N AP V V P+ SI+ +G S ++ C G P WSR+ +P+G Q + +
Sbjct: 1673 NQAP--LVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGT-QQRHQGS 1729
Query: 563 TLTLISTKMEDSGVYLC--EGINQAGRSRKEVELIIQVTPKDIKLTAFP--SESVKEGDT 618
L S + D+GVY+C ++Q+ SR E+ L+ + K I +T S+SV+ G
Sbjct: 1730 ELHFPSVQPSDAGVYICTCRNLHQSNTSRAEL-LVTEAPSKPITVTVEEQRSQSVRPGAD 1788
Query: 619 VIISCTCGNVPETWIILKKKAETGDTVLKSID--GAYTIRKAQLKDAGVYECESKNKVGS 676
V CT + + ++ + G +++D G TIR QL DAG Y C N
Sbjct: 1789 VTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAM 1848
Query: 677 QLRSLTLDVQ 686
+ TL VQ
Sbjct: 1849 DQGTATLHVQ 1858
Score = 64.3 bits (155), Expect = 4e-10
Identities = 118/544 (21%), Positives = 197/544 (36%), Gaps = 88/544 (16%)
Query: 194 VCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTK-LQEGGSVTMTCSSEGLP 252
VCRA +ID +++ + + + I + S+ + EG ++ + C G
Sbjct: 2695 VCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQA 2754
Query: 253 APEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKP 312
++ W K+ + H + + L L + DSG YVC + G V + ++
Sbjct: 2755 HAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASG 2814
Query: 313 FTVEISPGPRIAAQI-----------GDSVMLTCSVMGCESPSFSW---------RTQID 352
+ P P A I G ++ L C V G +W R Q+
Sbjct: 2815 SSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVH 2874
Query: 353 SPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDP----- 407
PL L L+ VS + Y C VT LE + V + P
Sbjct: 2875 GPL------------LRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPG 2922
Query: 408 -----EIEMSGG-LVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSL 461
IE S + G ++ ++C VP ++ K L + ++
Sbjct: 2923 LAQPIYIEASSSHVTEGQTLDLNCVVPG---QAHAQVTWYKRGGSLPARHQTHGSQLR-- 2977
Query: 462 ENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAP--------RD 513
+ + D+G+ VC+A P+Q S V V P R
Sbjct: 2978 -------LHLVSPADSGE-YVCRAASGPG-----PEQEAS---FTVTVPPSEGSSYRLRS 3021
Query: 514 TTVLVS-PSSILEEGSSVNMTCLSQGFPAP-KILWSRQLPNGELQP---LSENAT-LTLI 567
+ + PSS +++G + CL AP + W + N EL+ +S N + +T++
Sbjct: 3022 PVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTR--NQELEDNVHISPNGSIITIV 3079
Query: 568 STKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGN 627
T+ + G Y C N G ++ V L + P L P VK G V + C
Sbjct: 3080 GTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGP-VWVKVGKAVTLECVSAG 3138
Query: 628 VPET---WIILKK---KAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSL 681
P + W + K E L I A+ DAG Y C ++N +G+ + +
Sbjct: 3139 EPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQV 3198
Query: 682 TLDV 685
+ V
Sbjct: 3199 EVIV 3202
Score = 62.0 bits (149), Expect = 2e-09
Identities = 85/389 (21%), Positives = 140/389 (35%), Gaps = 51/389 (13%)
Query: 310 EKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLT 369
+ P VE+ P I Q G S L C V G F W + P+ + S L
Sbjct: 1674 QAPLVVEVHPARSIVPQ-GGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELH 1732
Query: 370 LSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDP-----EIEMSGGLVNGSSVTVS 424
V + Y+CT H+ ++ + P P E + S + G+ VT
Sbjct: 1733 FPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFI 1792
Query: 425 CKVPSVYPLDRLE-IELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVC 483
C S P L L G+ ++F +++++ + D G +
Sbjct: 1793 CTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQ-----------LSDAGTYVCT 1841
Query: 484 QAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVS---PSSILEEGSSVNMTCLSQGFP 540
+ + D Q T TL+V + + +VS P ++ G C + G P
Sbjct: 1842 GSNMFAMD--------QGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSP 1893
Query: 541 APKILWSRQLPNGELQPLSE--NATLTLISTKMEDSGVYLCEGINQAGRSRKEVEL---- 594
P + W+ P G+L ++ L L + + D YLC + AG+ L
Sbjct: 1894 TPTLEWTGG-PGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHG 1952
Query: 595 ----IIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSID 650
+QV+P+ ++ A G TV + C VP I +K+ + +S
Sbjct: 1953 GGGPRVQVSPERTQVHA--------GRTVRLYCRAAGVPSATITWRKEGGSLPPQARSER 2004
Query: 651 ---GAYTIRKAQLKDAGVYECESKNKVGS 676
I DAG Y C + + G+
Sbjct: 2005 TDIATLLIPAITTADAGFYLCVATSPAGT 2033
Score = 62.0 bits (149), Expect = 2e-09
Identities = 84/375 (22%), Positives = 141/375 (37%), Gaps = 49/375 (13%)
Query: 29 TTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFG 88
TT Q G++V L C G F W +++ S L G+ T L +
Sbjct: 3302 TTVPEHASVQAGETVQLQCLAHGTPPLTFQW-SRVGSSLPGRAT--ARNELLHFERAAPE 3358
Query: 89 NEHSYLCTATCESRKLEKGIQVEIYSFP-----------KDPEIHLSGPLEA---GKPIT 134
+ Y C T + E Q+ + P P + ++ LE G +
Sbjct: 3359 DSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVE 3418
Query: 135 VKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLV 194
C+V P DR G L +E + S++ L + + + +
Sbjct: 3419 FHCAV----PSDR-------GTQLRWFKEGGQLPPGHSVQDGVLRIQ--NLDQSCQGTYI 3465
Query: 195 CRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQE---GGSVTMTCSSEGL 251
C+A + QA +L + P + +N T +Q G +V C + G
Sbjct: 3466 CQAHGPWGKA-------QASAQLVIQALPS---VLINIRTSVQTVVVGHAVEFECLALGD 3515
Query: 252 PAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEK 311
P P++ WSK + + + + + + D+G Y C N G + V L+VQ
Sbjct: 3516 PKPQVTWSKVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQAL 3575
Query: 312 PFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLS 371
P +IS + G + + C G +P SW +++D L R E N+ L L
Sbjct: 3576 P---QISMPQEVRVPAGSAAVFPCIASGYPTPDISW-SKLDGSLPPDSRLE--NNMLMLP 3629
Query: 372 PVSFENEHSYLCTVT 386
V ++ +Y+CT T
Sbjct: 3630 SVRPQDAGTYVCTAT 3644
Score = 61.6 bits (148), Expect = 3e-09
Identities = 114/518 (22%), Positives = 190/518 (36%), Gaps = 86/518 (16%)
Query: 221 ISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIA 280
+SP + S +P+ + EG ++ + C P I W K+ + +H + + L L
Sbjct: 2628 VSPPIRIESSSPT--VVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQ 2685
Query: 281 MRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEIS-PGPRIAAQI---------GDS 330
M + DSG YVC N I + E +++ P S PG + +I G++
Sbjct: 2686 MSVADSGEYVCRANNNI--DALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGET 2743
Query: 331 VMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHK 390
+ L C V G +W + S S + S L L VS + Y+C V
Sbjct: 2744 LDLNCVVPGQAHAQVTWHKRGGSLPS---HHQTRGSRLRLHHVSPADSGEYVCRVMGSSG 2800
Query: 391 KLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLE---IELLKGETIL 447
LE + V IE SG S V P P R+E + +G+T+
Sbjct: 2801 PLEASVLV---------TIEASG------SSAVHVPAPGGAPPIRIEPSSSRVAEGQTL- 2844
Query: 448 ENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLH-----------IDDMEFEP 496
D+K + T G L + ++H D E+
Sbjct: 2845 ---------DLKCVVPGQAHAQV--TWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSC 2893
Query: 497 KQRQSTQTL----YVNVAPRDTTVLVSP-----------SSILEEGSSVNMTCLSQGFPA 541
+ S+ TL V + P + +P SS + EG ++++ C+ G
Sbjct: 2894 QVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAH 2953
Query: 542 PKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPK 601
++ W ++ + + + + L L DSG Y+C + G +E + V P
Sbjct: 2954 AQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPG-PEQEASFTVTVPPS 3012
Query: 602 D---------IKLTAFPSESVKEGDTVIISCTC--GNVPETWIILKKKAETGDTVLKSID 650
+ + PS +V++G C G P + + E D V S +
Sbjct: 3013 EGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPN 3072
Query: 651 GA-YTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQG 687
G+ TI + + G Y C + N G + L V G
Sbjct: 3073 GSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHG 3110
Score = 61.2 bits (147), Expect = 3e-09
Identities = 99/507 (19%), Positives = 187/507 (36%), Gaps = 79/507 (15%)
Query: 226 TVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMED 285
TV + S+++ EG ++ + C G ++ W K+ + +H + L L+ + D
Sbjct: 2438 TVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPAD 2497
Query: 286 SGIYVCEGVNLIGKNRKEVELIVQEK---------PFTVEISPGPRIAAQIGDSVMLTCS 336
SG YVC V G V + +Q++ + V I A G ++ L C
Sbjct: 2498 SGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLAN-GHTLDLNCL 2556
Query: 337 VMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGI 396
V + +W + S S R + S L + V+ + Y+C V+ G E +
Sbjct: 2557 VASQAPHTITWYKRGGSLPS---RHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSL 2613
Query: 397 QVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIE---LLKGETILENIEFL 453
V I+ SG S VPSV P R+E +++G+T+ N
Sbjct: 2614 IV---------TIQGSG----------SSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVA 2654
Query: 454 EDTD-------------MKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQ 500
+ + S ++ D+G+ VC+A +ID +E
Sbjct: 2655 RQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGE-YVCRANNNIDALE------- 2706
Query: 501 STQTLYVNVAPRDTTV----------LVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQL 550
++ ++V+P + + S SS + EG ++++ C+ G ++ W ++
Sbjct: 2707 --ASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRG 2764
Query: 551 PNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFP- 609
+ + + L L DSG Y+C + +G V + I+ + P
Sbjct: 2765 GSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPG 2824
Query: 610 ----------SESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQ 659
S V EG T+ + C + K+ + + +
Sbjct: 2825 GAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVS 2884
Query: 660 LKDAGVYECESKNKVGSQLRSLTLDVQ 686
D+G Y C+ G+ S+ + ++
Sbjct: 2885 PADSGEYSCQVTGSSGTLEASVLVTIE 2911
Score = 56.6 bits (135), Expect = 8e-08
Identities = 84/417 (20%), Positives = 154/417 (36%), Gaps = 26/417 (6%)
Query: 32 ESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEH 91
E+ + G + +L CS TG +P W +++ SPL + EG TL + V+ +
Sbjct: 3218 EAELTVEAGHTATLRCSATGSPAPTIHW-SKLRSPLPWQHRLEG--DTLIIPRVAQQDSG 3274
Query: 92 SYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEID 151
Y+C AT + E I + + S P + ++AG+ + ++C P
Sbjct: 3275 QYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPL------ 3328
Query: 152 LLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRA--KLHIDEMDSVPT 209
+ + S A + L + ED G+ CR K+ E +
Sbjct: 3329 TFQWSRVGSSLPGRATARNELLHFE------RAAPEDSGRYR-CRVTNKVGSAEAFAQLL 3381
Query: 210 VRQAVKELQVYISPKNTVISVNPSTKLQE---GGSVTMTCSSEGLPAPEIFWSKKLDNGN 266
V+ L P + +V + +L+ G SV C+ ++ W K+
Sbjct: 3382 VQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLP 3441
Query: 267 LQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQ 326
H + L + + G Y+C+ GK + +L++Q P +
Sbjct: 3442 PGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVV 3501
Query: 327 IGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVT 386
+G +V C +G P +W G V+S G + ++ V + Y CT T
Sbjct: 3502 VGHAVEFECLALGDPKPQVTWSKVGGHLRPGIVQSGG---VVRIAHVELADAGQYRCTAT 3558
Query: 387 CGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKG 443
+ + + + + P+ + + GS+ C + S YP + L G
Sbjct: 3559 NAAGTTQSHVLLLVQALPQ-ISMPQEVRVPAGSAAVFPC-IASGYPTPDISWSKLDG 3613
Score = 50.1 bits (118), Expect = 8e-06
Identities = 139/688 (20%), Positives = 241/688 (35%), Gaps = 79/688 (11%)
Query: 38 QIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTA 97
Q G CS TG +P W L K G L + V ++ YLC A
Sbjct: 1878 QPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHG--GILRLPAVEPTDQAQYLCRA 1935
Query: 98 TCESRKLEKGIQVEIYSFPKDPEIHLSGP---LEAGKPITVKCSVADVYPFDRLEIDLLK 154
+ + + ++ P + +S + AG+ + + C A V I K
Sbjct: 1936 HSSAGQQVARAVLHVHG-GGGPRVQVSPERTQVHAGRTVRLYCRAAGV---PSATITWRK 1991
Query: 155 GDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAV 214
+ Q E D +L ++ D G L + V +
Sbjct: 1992 EGGSLPPQARSERTDIATLLIPAITTA------DAGFYLCVATSPAGTAQARIQVVVLSA 2045
Query: 215 KELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNA 274
+ P + S +PS + EG ++ + C G ++ W ++ + +
Sbjct: 2046 SDAS---PPPVKIESSSPS--VTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGS 2100
Query: 275 TLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFT---------------VEISP 319
L L + DSG YVC N G KE + V T + I P
Sbjct: 2101 RLRLPQVSPADSGEYVCRVEN--GSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEP 2158
Query: 320 GPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEH 379
A+ G ++ L C V G +W + S L + ++ G S L L V+ +
Sbjct: 2159 SSSHVAE-GQTLDLNCVVPGQAHAQVTWHKRGGS-LPARHQTHG--SLLRLHQVTPADSG 2214
Query: 380 SYLCTVTCGHKKLEKGIQVELYSF----PRDP-EIEMSGGLV-NGSSVTVSCKVPSVYPL 433
Y+C V LE + V + + P P IE S V G ++ +SC V
Sbjct: 2215 EYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVA----- 2269
Query: 434 DRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFI--PTIEDTGKALVCQAKLHIDD 491
G+ + + + + +I + D G+ VC+A +
Sbjct: 2270 ---------GQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQ-YVCRAS---NG 2316
Query: 492 MEFEPKQRQSTQTLYVNVA-PRDTT--VLVSPSSI-LEEGSSVNMTCLSQGFPAPKILWS 547
ME T T N+A P +T + + PSS + EG ++++ C+ G ++ W
Sbjct: 2317 MEASITVTV-TGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWH 2375
Query: 548 RQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTA 607
++ + ++ + + L L DSG Y+C + + V + I+ L
Sbjct: 2376 KRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGV 2435
Query: 608 FP-------SESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQL 660
P S V EG T+ ++C + K+ + + + +
Sbjct: 2436 TPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTP 2495
Query: 661 KDAGVYECESKNKVGSQLRSLTLDVQGR 688
D+G Y C G+Q S+ + +Q R
Sbjct: 2496 ADSGEYVCRVVGSSGTQEASVLVTIQQR 2523
Score = 46.2 bits (108), Expect = 1e-04
Identities = 46/202 (22%), Positives = 79/202 (39%), Gaps = 22/202 (10%)
Query: 511 PRDTTVLVSPSSILEEGSSVNMTCLSQG-FPAPKILWSRQLPNGEL--QPLSENATLTLI 567
P TV S + G+ V C ++ PA ++W+R L NG+L + + N LT+
Sbjct: 1770 PITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTR-LHNGKLPTRAMDFNGILTIR 1828
Query: 568 STKMEDSGVYLCEGINQAGRSRKEVELIIQVT---PKDIKLTAFPSESVKEGDTVIISCT 624
+ ++ D+G Y+C G N + L +Q + + P +V+ G C+
Sbjct: 1829 NVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCS 1888
Query: 625 CGNVPETWI--------ILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGS 676
P + L KA+ +L+ + + D Y C + + G
Sbjct: 1889 ATGSPTPTLEWTGGPGGQLPAKAQIHGGILR-------LPAVEPTDQAQYLCRAHSSAGQ 1941
Query: 677 QLRSLTLDVQGRENNKDYFSPE 698
Q+ L V G + SPE
Sbjct: 1942 QVARAVLHVHGGGGPRVQVSPE 1963
Score = 45.4 bits (106), Expect = 2e-04
Identities = 29/86 (33%), Positives = 43/86 (50%), Gaps = 4/86 (4%)
Query: 228 ISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLS--GNATLTLIAMRMED 285
IS+ ++ G + C + G P P+I WSK +G+L S N L L ++R +D
Sbjct: 3578 ISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKL--DGSLPPDSRLENNMLMLPSVRPQD 3635
Query: 286 SGIYVCEGVNLIGKNRKEVELIVQEK 311
+G YVC N GK + L V E+
Sbjct: 3636 AGTYVCTATNRQGKVKAFAHLQVPER 3661
Score = 43.5 bits (101), Expect = 7e-04
Identities = 94/490 (19%), Positives = 170/490 (34%), Gaps = 47/490 (9%)
Query: 233 STKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCE 292
S L G ++ + C I W K+ + +H + L + + DSG YVC
Sbjct: 2542 SASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCH 2601
Query: 293 GVNLIGKNRKEVELIV----QEKPFTVEISPGPRIAAQI-----GDSVMLTCSVMGCESP 343
N G +E LIV +SP RI + G ++ L C V
Sbjct: 2602 VSN--GAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQA 2659
Query: 344 SFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSF 403
+W + S S R + S L L +S + Y+C LE I + +
Sbjct: 2660 IITWYKRGGSLPS---RHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPS 2716
Query: 404 PRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIEL---LKGETILENIEFLEDTDMKS 460
P GSS+ + + S + + ++L + G+ + + S
Sbjct: 2717 AGSPSAP-------GSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPS 2769
Query: 461 ---LENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPK---QRQSTQTLYVNVAPRDT 514
L + + D+G+ VC+ +E + + ++V
Sbjct: 2770 HHQTRGSRLRLHHVSPA-DSGE-YVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAP 2827
Query: 515 TVLVSPSSI-LEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMED 573
+ + PSS + EG ++++ C+ G ++ W ++ N + L L D
Sbjct: 2828 PIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPAD 2887
Query: 574 SGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFP-----------SESVKEGDTVIIS 622
SG Y C+ +G E +++ + P P S V EG T+ ++
Sbjct: 2888 SGEYSCQVTGSSG--TLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLN 2945
Query: 623 CTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVG-SQLRSL 681
C + K+ + ++ + D+G Y C + + G Q S
Sbjct: 2946 CVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQEASF 3005
Query: 682 TLDVQGRENN 691
T+ V E +
Sbjct: 3006 TVTVPPSEGS 3015
Score = 40.4 bits (93), Expect = 0.006
Identities = 30/110 (27%), Positives = 44/110 (40%), Gaps = 15/110 (13%)
Query: 197 AKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEI 256
A H DE P + + P V S + G +VT TC + G+P P I
Sbjct: 384 ASFHCDEESDCPD-----RSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPII 438
Query: 257 FWSKKLDNGNL--------QHLSGNATLTLIAMRMEDSGIYVCEGVNLIG 298
W +L+ G++ G TL + ++ D G Y CE +N G
Sbjct: 439 NW--RLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
Score = 40.0 bits (92), Expect = 0.008
Identities = 23/75 (30%), Positives = 34/75 (45%), Gaps = 3/75 (4%)
Query: 26 KIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRT---QIDSPLNGKVTNEGTTSTLTM 82
++ T P A G +V+ TC G +P +WR I S VT+EG TL +
Sbjct: 407 QVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLII 466
Query: 83 NPVSFGNEHSYLCTA 97
V ++ +Y C A
Sbjct: 467 RDVKESDQGAYTCEA 481
Score = 36.6 bits (83), Expect = 0.086
Identities = 24/75 (32%), Positives = 32/75 (42%), Gaps = 3/75 (4%)
Query: 312 PFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRT---QIDSPLSGKVRSEGTNSTL 368
P V P I A G +V TC +G +P +WR I S V SEG TL
Sbjct: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTL 464
Query: 369 TLSPVSFENEHSYLC 383
+ V ++ +Y C
Sbjct: 465 IIRDVKESDQGAYTC 479
Score = 35.8 bits (81), Expect = 0.15
Identities = 24/81 (29%), Positives = 35/81 (43%), Gaps = 6/81 (7%)
Query: 527 GSSVNMTCLSQGFPAPKILWSRQLPNGELQP----LSENATLTLI--STKMEDSGVYLCE 580
G +V TC++ G P P I W + P SE TLI K D G Y CE
Sbjct: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCE 480
Query: 581 GINQAGRSRKEVELIIQVTPK 601
+N G + ++++ P+
Sbjct: 481 AMNARGMVFGIPDGVLELVPQ 501
>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
Length = 2623
Score = 105 bits (261), Expect = 2e-22
Identities = 152/714 (21%), Positives = 270/714 (37%), Gaps = 87/714 (12%)
Query: 26 KIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLN-----GKVTNEGTTSTL 80
+IE + R GD + L CS TG P WR + ++ G + +L
Sbjct: 1942 RIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSL 2001
Query: 81 TMNPVSFGNEHSYLCTATCESRK--LEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCS 138
+ V+ + YLC A + + + + + D + + + GK V C
Sbjct: 2002 FIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCK 2061
Query: 139 VADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETK----SLEVTFTPVIEDIGKVLV 194
A P + L G + + + + R T +L V E+
Sbjct: 2062 -ASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCY 2120
Query: 195 CRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAP 254
+ L DEM TV A ++ S + +++ G + + C G P P
Sbjct: 2121 AQNTLGKDEMKVHLTVITAAPRIRQ---------SNKTNKRIKAGDTAVLDCEVTGDPKP 2171
Query: 255 EIFW---SKKLDNGNLQHLS--GNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQ 309
+IFW S + + ++ + N +LT+ +++ DSG YVC N G + K +L V
Sbjct: 2172 KIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVV 2231
Query: 310 EKPFTVEISPGPRIAAQIG----DSVMLTCSVMGCESPSFSW----RTQIDSPLSGKVRS 361
KP + R + C G SP W + +P G +
Sbjct: 2232 SKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRIT 2291
Query: 362 EGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIE--MSGGLVN-- 417
N TL + V + ++C + +Q+E+ R P + +V
Sbjct: 2292 VHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQL 2351
Query: 418 GSSVTVSCKVPSVYPLDRLEIELLKGETILEN----IEFLEDTDMKSLENKSLEMTFIPT 473
G S ++C V P + + I L T N ++L ++ + +K+ T
Sbjct: 2352 GKSTALNCSVDGNPPPEIIWI--LPNGTRFSNGPQSYQYLIASNGSFIISKT-------T 2402
Query: 474 IEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILE-EGSSVNM 532
ED GK C A+ + +E + + + + + + +P ++ G S+++
Sbjct: 2403 REDAGKYR-CAARNKVGYIE---------KLVILEIGQKPVILTYAPGTVKGISGESLSL 2452
Query: 533 TCLSQGFPAPKILWSRQLPNGELQP---------LSENATLTLISTKMEDSGVYLCEGIN 583
C+S G P P I W+ +P+G + L +N TL + D G Y+C+ N
Sbjct: 2453 HCVSDGIPKPNIKWT--MPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQN 2510
Query: 584 QAGRSRKEVELIIQVTPKDIKLTAFPSESV--KEGDTVIISCTCGNVPE---TW------ 632
G + V ++I P ++T P S+ + G + C VP+ TW
Sbjct: 2511 SVGHTLITVPVMIVAYPP--RITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHS 2568
Query: 633 -IILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 685
+ K T + + G I+ Q D+G+Y+C +KN +GS + + V
Sbjct: 2569 LLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
Score = 94.7 bits (234), Expect = 3e-19
Identities = 111/495 (22%), Positives = 190/495 (38%), Gaps = 69/495 (13%)
Query: 239 GGSVTMTCSSEGLPAPEIFWS-------KKLDNGNLQ-HLSGNATLTLIAMRMEDSGIYV 290
G S+ + C+++G P P ++W K L N + L N TL + + D G Y
Sbjct: 1857 GESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYE 1916
Query: 291 CEGVNLIGKNRKEVELIVQEKPFT--VEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWR 348
C + G R+ V L ++E+ + +E + R GD ++L CS G P WR
Sbjct: 1917 CIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWR 1976
Query: 349 TQIDSPLSGKVRSEG-----TNSTLTLSPVSFENEHSYLCTV--TCGHKKLEKGIQVELY 401
+ + + R N +L + V+ ++ YLC G + + + L
Sbjct: 1977 LPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLK 2036
Query: 402 SFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKS- 460
D + +++G V CK S P+ + L G T++ N +D+ ++
Sbjct: 2037 PAKIDHKQYFRKQVLHGKDFQVDCKA-SGSPVPEISWSLPDG-TMINNAMQADDSGHRTR 2094
Query: 461 ----LENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFE-------PKQRQSTQTLYVNV 509
N +L + E+ Q L D+M+ P+ RQS +T
Sbjct: 2095 RYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKT----- 2149
Query: 510 APRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLS-------ENA 562
+ ++ G + + C G P PKI W LP+ ++ S N
Sbjct: 2150 -----------NKRIKAGDTAVLDCEVTGDPKPKIFW--LLPSNDMISFSIDRYTFHANG 2196
Query: 563 TLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDI-----KLTAFPSESVKEGD 617
+LT+ K+ DSG Y+C N +G K +L + P I T + +V+
Sbjct: 2197 SLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSK 2256
Query: 618 TVIISCTCGNVPE---TWI----ILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECES 670
C P WI I G + +G IR +L D+ + C +
Sbjct: 2257 K-HFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVA 2315
Query: 671 KNKVGSQLRSLTLDV 685
+N+ G + + L+V
Sbjct: 2316 RNEGGESVLVVQLEV 2330
Score = 84.7 bits (208), Expect = 3e-16
Identities = 105/500 (21%), Positives = 190/500 (38%), Gaps = 76/500 (15%)
Query: 236 LQEGGSVTMTCSSEGLPAPEIFW--------SKKLDNGNLQHLSGNATLTLIAMRMEDSG 287
+ G +V + C +EG P+P + W S+ ++ + TL L + + D G
Sbjct: 1757 VHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRG 1816
Query: 288 IYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSW 347
Y C N G++ V++ V P + I G+S+ L C+ G PS W
Sbjct: 1817 FYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYW 1876
Query: 348 RTQIDSPLSGKVRSEG-----TNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYS 402
+ + + +N TL + ++ + +Y C T + + + +
Sbjct: 1877 VLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEE 1936
Query: 403 FPRDPEIEMSGGL---VN-GSSVTVSCKV---PSVYPLDRLEIELLKGETILENIEFLED 455
P IE + VN G + ++C P + RL + + + +
Sbjct: 1937 RVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQ------QHRVG 1990
Query: 456 TDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTT 515
+ + N SL + + T +D+G +C A+ + D + ++V+ R
Sbjct: 1991 SWIHVYPNGSLFIGSV-TEKDSG-VYLCVARNKMGD-----------DLILMHVSLRLKP 2037
Query: 516 VLVSPSSILEE----GSSVNMTCLSQGFPAPKILWSRQLPNGEL---------------- 555
+ + G + C + G P P+I WS LP+G +
Sbjct: 2038 AKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWS--LPDGTMINNAMQADDSGHRTRR 2095
Query: 556 QPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKE 615
L N TL + + G Y C N G+ +V L + I+ + ++ +K
Sbjct: 2096 YTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKA 2155
Query: 616 GDTVIISCTCGNVPET---WIILKKKAETGDTVLKSID-------GAYTIRKAQLKDAGV 665
GDT ++ C P+ W++ + D + SID G+ TI K +L D+G
Sbjct: 2156 GDTAVLDCEVTGDPKPKIFWLL-----PSNDMISFSIDRYTFHANGSLTINKVKLLDSGE 2210
Query: 666 YECESKNKVGSQLRSLTLDV 685
Y C ++N G + LDV
Sbjct: 2211 YVCVARNPSGDDTKMYKLDV 2230
Score = 74.7 bits (182), Expect = 3e-13
Identities = 104/502 (20%), Positives = 194/502 (38%), Gaps = 74/502 (14%)
Query: 244 MTCSSEGLPAPEIFW---------SKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGV 294
+ C + G P P I W SK+ N +Q L N TL++ + ++D G Y+C
Sbjct: 1668 LPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLP-NGTLSIQRVEIQDRGQYLCSAS 1726
Query: 295 NLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSW----RTQ 350
NL G + V L V P + I G +V L C G SP+ +W +T
Sbjct: 1727 NLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTV 1786
Query: 351 IDSPLSGKVRSEGT-NSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEI 409
+ G ++ T + TL L +S + Y C + + +++++ + P
Sbjct: 1787 VSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILE 1846
Query: 410 EMSGGLVN--GSSVTVSCKV-----PSVYPL--DRLEIELLK---GETILENIEFLEDTD 457
+ +V G S+ + C PSVY + D E++ L+ + L + L +
Sbjct: 1847 QRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRN 1906
Query: 458 MKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVL 517
+ S + + E + + ++ + + E ++ T+ +
Sbjct: 1907 LASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNF----------- 1955
Query: 518 VSPSSILEEGSSVNMTCLSQGFPAPKILW--------SRQLPNGELQPLSENATLTLIST 569
G + + C + G P P+I+W +Q G + N +L + S
Sbjct: 1956 ---------GDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSV 2006
Query: 570 KMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGN-- 627
+DSGVYLC N+ G + + +++ P I + + V G + C
Sbjct: 2007 TEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSP 2066
Query: 628 VPE-TW-----IILKKKAETGDTVLKS------IDGAYTIRKAQLKDAGVYECESKNKVG 675
VPE +W ++ + D+ ++ +G K + + G Y C ++N +G
Sbjct: 2067 VPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLG 2126
Query: 676 S-----QLRSLTLDVQGRENNK 692
L +T + R++NK
Sbjct: 2127 KDEMKVHLTVITAAPRIRQSNK 2148
Score = 58.2 bits (139), Expect = 3e-08
Identities = 46/183 (25%), Positives = 74/183 (40%), Gaps = 20/183 (10%)
Query: 521 SSILEEGSSVNMTCLSQGFPAPKILWSR---------QLPNGELQPLSENATLTLISTKM 571
S + S + C + G P P I W+R + N +Q L N TL++ ++
Sbjct: 1657 SFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLP-NGTLSIQRVEI 1715
Query: 572 EDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE- 630
+D G YLC N G V L + P I +V G TV + C P
Sbjct: 1716 QDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSP 1775
Query: 631 --TWI-----ILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTL 683
TWI ++ + ++ + ++DG + + D G Y+C + N G SL +
Sbjct: 1776 TVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQD--SLLV 1833
Query: 684 DVQ 686
+Q
Sbjct: 1834 KIQ 1836
Score = 41.6 bits (96), Expect = 0.003
Identities = 44/180 (24%), Positives = 78/180 (43%), Gaps = 19/180 (10%)
Query: 221 ISPKNTVISVNPSTKLQE----GGSVTMTCSSEGLPAPEIFWSKKLDNGN---LQHLSGN 273
+ K T+IS + +TKL+ GG+V + C +G P P + W L +G+ ++S +
Sbjct: 468 VKHKWTMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDW--LLADGSKVRAPYVSED 525
Query: 274 ATLTL-----IAMRMEDS---GIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAA 325
+ + + ++M DS G+Y C N + + V E G
Sbjct: 526 GRILIDKSGKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTV 585
Query: 326 QIGDSVMLTCSVMGCESPSFSWRTQIDSPL--SGKVRSEGTNSTLTLSPVSFENEHSYLC 383
IG+++ L C G S SW ++ L S + + N TL + V+ +++ Y C
Sbjct: 586 FIGETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRC 645
Score = 38.9 bits (89), Expect = 0.017
Identities = 76/337 (22%), Positives = 126/337 (37%), Gaps = 57/337 (16%)
Query: 371 SPVSFENEHSYL-----------CTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGS 419
SP++F E+ Y+ C + GH + I + LYS D + + +
Sbjct: 341 SPIAFTEENDYIVLNTSFSTFLVCNIDYGHIQPVWQI-LALYS---DSPLILERSHLLSE 396
Query: 420 SVTVSCKVPSVYPLDRLEIELLKGETILENIE--FLEDTDMKSLENKSLEMTFIPTIEDT 477
+ + K V P K E I NIE D + SL++ T T
Sbjct: 397 TPQLYYKYKQVAP---------KPEDIFTNIEADLRADPSWLMQDQISLQLNRTATTFST 447
Query: 478 GKALVCQ-AKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLS 536
+ A++ + E P + + T N + TVLV G +V + C
Sbjct: 448 LQIQYSSDAQITLPRAEMRPVKHKWTMISRDNNTKLEHTVLV--------GGTVGLNCPG 499
Query: 537 QGFPAPKILWSRQLPNGELQP-LSENATLTL-ISTKME-------DSGVYLCEGINQAGR 587
QG P P + W + P +SE+ + + S K+E D+GVY C N
Sbjct: 500 QGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCISSNYDDA 559
Query: 588 SRKEVELIIQVTPKDIKLTAFPSESVKE----GDTVIISCTCGNVPE---TWIILKKKAE 640
L ++T + + A+ + G+T+ + C +P+ +W+I
Sbjct: 560 D----ILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVIPGNNVL 615
Query: 641 TGDTVLKSIDGAYTIRKAQL--KDAGVYECESKNKVG 675
+ K + T+R Q+ KD G Y C + N G
Sbjct: 616 YQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 103 bits (258), Expect = 4e-22
Identities = 126/500 (25%), Positives = 210/500 (42%), Gaps = 76/500 (15%)
Query: 235 KLQEGGSVTMTCSSEGLPAPEIFWSKK----LDNGNLQHLSGNATLTLIAMRMEDSGIYV 290
K + ++T+ C S +P P I W K + LQ L L + ++ DSG Y+
Sbjct: 1459 KTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYL 1518
Query: 291 CEGVNLIGKNRKEVELIVQEKPFTVEISP----------------GPRIAAQIGDS--VM 332
C N+ G++ ++ +++Q P ++ G +I ++
Sbjct: 1519 CVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAY 1578
Query: 333 LTCSVMGCESPSFSWRTQIDSPLSG--KVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHK 390
L C P +W + D PLS +V L + V EN Y C + ++
Sbjct: 1579 LYCDTNAIPPPDLTWYRE-DQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKAS--NE 1635
Query: 391 KLEKGIQVELYSFPR-----DPEIEMSGGLVNGSSVTVSCKVPSV-YPLDRLEIELLKGE 444
E + EL D E + VN SS TVS + P++ P+ +
Sbjct: 1636 VGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS-TVSLQCPALGNPVPTIS------- 1687
Query: 445 TILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQT 504
+ + F ++ LE+ + + D + +C A E + + T
Sbjct: 1688 WLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAA-SYMCVA-------ENQAGSAEKLFT 1739
Query: 505 LYVNVAPRDTTV-LVSPSSILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGE-LQPLS 559
L V V PR + L ++IL SSV++ C P P++ W S+ L GE + L
Sbjct: 1740 LRVQVPPRIAGLDLEQVTAILN--SSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLP 1797
Query: 560 ENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSES--VKEGD 617
TL L ++ DSG+Y CE +N AGR +K V+L + V P + P ++ V+ GD
Sbjct: 1798 GTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGD 1857
Query: 618 TVIISCTCGNVPE---TW------IILKKKAET--GDTVLKSIDGAYTIRKAQLKDAGVY 666
++SC +PE TW ++L ++ + G L+ I++AQ+ D G+Y
Sbjct: 1858 KAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLE-------IQEAQVSDKGLY 1910
Query: 667 ECESKNKVGSQLRSLTLDVQ 686
C+ N G +R+ TL VQ
Sbjct: 1911 SCKVSNVAGEAVRTFTLTVQ 1930
Score = 103 bits (257), Expect = 6e-22
Identities = 159/682 (23%), Positives = 252/682 (36%), Gaps = 88/682 (12%)
Query: 42 SVSLTCSTTGCESPFFSW---RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTAT 98
SV+L C +G P SW + S + V+ +G L + + SY C A+
Sbjct: 711 SVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV--LRIEQAQLSDAGSYRCVAS 768
Query: 99 --CESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGD 156
S +L G++V + P L GP+ P+ + C+
Sbjct: 769 NVAGSTELRYGLRVNVPPRITLPP-SLPGPVLVNTPVRLTCNATGA-----------PSP 816
Query: 157 HLMKSQEFLEDADRKS-LETKSLEVTFTPVIEDIGKVLVCRAKLHIDE-------MDSVP 208
LM +L+D + S T L+V G+VL + D + +V
Sbjct: 817 TLM----WLKDGNPVSPAGTPGLQVF------PGGRVLTLASARASDSGRYSCVAVSAVG 866
Query: 209 TVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK---LDNG 265
RQ V LQV++ P +N S E SV + C S +P P + W K L+
Sbjct: 867 EDRQDVV-LQVHMPPSILGEELNVSVVANE--SVALECQSHAMPPPVLSWWKDGRPLEPR 923
Query: 266 NLQHLSGN-ATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIA 324
HLS + A L + + D+G Y CE +N G++ K L V P + +
Sbjct: 924 PGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAP-VFPLRESHTLT 982
Query: 325 AQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRS----EGTNSTLTLSPVSFENEHS 380
+ G L+C G P SWR PL G+ L L E +
Sbjct: 983 VREGHPTSLSCECRGVPFPKISWRKD-GQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGT 1041
Query: 381 YLCTVTCGHKKLEKGIQVELY-----SFPRDPEIEMSGGLVNGSSVTVSC----KVPSVY 431
Y C + + +Q+E++ + PR+P ++S +V T+ C K P
Sbjct: 1042 YTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVS--VVQDGVATLECNATGKPPPTV 1099
Query: 432 PLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDD 491
+R G+ + + +SL + + + L +A+ +
Sbjct: 1100 TWER------DGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFEL 1153
Query: 492 MEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQ-- 549
P + N+ T L SP ++L C + G P P I W R
Sbjct: 1154 SVLVPPELIGDLDPLTNI----TAALHSPLTLL---------CEAMGIPPPAIRWFRGEE 1200
Query: 550 --LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTA 607
P + L+ L + T+ +DSG+Y C N+AG +R+ + + V P
Sbjct: 1201 PVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDL 1260
Query: 608 FPSESVKEGDTVIISCTCGNVPE---TWIILKKKAETGDTVLKSIDGA-YTIRKAQLKDA 663
V +G T + C P+ TW + GD S DG + +A L A
Sbjct: 1261 EEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSA 1320
Query: 664 GVYECESKNKVGSQLRSLTLDV 685
G Y C + N VG + + L V
Sbjct: 1321 GHYSCIAANAVGEKTKHFQLSV 1342
Score = 100 bits (250), Expect = 4e-21
Identities = 159/675 (23%), Positives = 257/675 (38%), Gaps = 88/675 (13%)
Query: 40 GDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATC 99
G V L C G P SW PL + +G + L + V G+ +Y C A
Sbjct: 2230 GSLVELPCEARGVPLPLVSWMKD-GEPLLSQSLEQGPS--LQLEAVGAGDSGTYSCVAVS 2286
Query: 100 ESRKLEKGIQVEIYSFPKDPEIHLSGP-----LEAGKPITVKCSVADVYPFDRLEIDLLK 154
E+ + + Q+ + + P I SG L G P+ + C A P +
Sbjct: 2287 EAGEARRHFQLTVM---EPPHIEDSGQPTELSLTPGAPMELLCD-AQGTPQPNITWH--- 2339
Query: 155 GDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAV 214
K + L + S T+ L V D G + C A+ ++ VR
Sbjct: 2340 -----KDGQALTRLENNSRATRVLRV------RDAG-LYTCLAESPAGAIEKSFRVRVQA 2387
Query: 215 KELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK----LDNGNLQHL 270
V V+ + P G + + CS E PAP+I W + ++ + Q
Sbjct: 2388 PPNIVGPRGPRFVVGLAP-------GQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFP 2440
Query: 271 SGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDS 330
L L A+ DSG Y C N G + + P T+ P P + + +
Sbjct: 2441 ERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVP-TIRSGP-PAVNVSVNQT 2498
Query: 331 VMLTCSVMGCESPSFSWRTQIDSPLSGK-----VRSEGTNSTLTLSPVSFENEHSYLCTV 385
+L C G +P SWR PL + + EG+ L + PV ++ YLC
Sbjct: 2499 ALLPCQADGVPAPLVSWRKD-RVPLDPRSPRFEILPEGS---LRIQPVLAQDAGHYLCLA 2554
Query: 386 TCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDR------LEIE 439
+ +G + + P I S S++T++ P++ P + L +
Sbjct: 2555 SNSAGSDRQGRDLRVLE---PPAIAPSP-----SNLTLTAHTPALLPCEASGSPKPLVVW 2606
Query: 440 LLKGETILENIEF-LEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQ 498
G+ ++F L+ + L + +L +T P +D+ + C + + +
Sbjct: 2607 WKDGQ----KLDFRLQQGAYRLLPSNALLLT-APGPQDSAQ-FECVVSNEVGEAH---RL 2657
Query: 499 RQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSR---QL-PNGE 554
Q T + +A T V+ + V +TC S G PAP + WS+ QL G
Sbjct: 2658 YQVTVHVPPTIADDQTDFTVTMMA------PVVLTCHSTGIPAPTVSWSKAGAQLGARGS 2711
Query: 555 LQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVK 614
+S + L + +G Y C N AG + K V L +Q +P +K +V
Sbjct: 2712 GYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPV-VKPLPSVVRAVA 2770
Query: 615 EGDTVIISCTCGNVPETWIILKKK---AETGDTVLKSIDGAYTIRKAQLKDAGVYECESK 671
E + V++ C +P I +K+ TG + G I A +DAG Y C +K
Sbjct: 2771 E-EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAK 2829
Query: 672 NKVGSQLRSLTLDVQ 686
N GS + L VQ
Sbjct: 2830 NSAGSAMGKTRLVVQ 2844
Score = 98.6 bits (244), Expect = 2e-20
Identities = 106/465 (22%), Positives = 184/465 (39%), Gaps = 51/465 (10%)
Query: 242 VTMTCSSEGLPAPEIFWSKK---LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIG 298
V + C + G+P P I W K+ + G + L + ED+G Y+C N G
Sbjct: 2774 VLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAG 2833
Query: 299 KNRKEVELIVQEKPFTVEISPG-PRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSG 357
+ L+VQ P I G P ++ G L C G P+ +W P+SG
Sbjct: 2834 SAMGKTRLVVQVPPV---IENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKD-GQPVSG 2889
Query: 358 KVRSEGT-----NSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMS 412
+EG + L + + ++ +Y CT + + + + + P +
Sbjct: 2890 ---AEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGD 2946
Query: 413 GGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIP 472
L G + + C P R+ + + E + E +L+ ++
Sbjct: 2947 RSLRLGDRLWLRCAARGS-PTPRIGWTV-NDRPVTEGVS--EQDGGSTLQRAAVSR---- 2998
Query: 473 TIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAP----RDTTVLVSPSSILEEGS 528
ED+G VC A+ + + Q+ ++V AP + LV P G
Sbjct: 2999 --EDSG-TYVCWAENRVG-------RTQAVSFVHVKEAPVLQGEAFSYLVEPV-----GG 3043
Query: 529 SVNMTCLSQGFPAPKILWSRQ---LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQA 585
S+ + C+ +G P P I W + L L+ +N +LT+ T+ +D+G Y C N+
Sbjct: 3044 SIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEM 3103
Query: 586 GRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWIILKKKAETG 642
G ++K V L++Q P + +V+ GD V + C P W+ +
Sbjct: 3104 GVAKKVVILVLQSAP--VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRAS 3161
Query: 643 DTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQG 687
+ DG+ + + DAG Y+C + N +GS L V+G
Sbjct: 3162 RRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRG 3206
Score = 94.7 bits (234), Expect = 3e-19
Identities = 125/512 (24%), Positives = 197/512 (38%), Gaps = 82/512 (16%)
Query: 212 QAVKELQVYISPKNTVISVNPSTKL--QEGGSVTMTCSSEGLPAPEIFWSKK----LDNG 265
Q ++ Q+ + T+ N + ++ E V + C + G+P P I W K +
Sbjct: 297 QQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTST 356
Query: 266 NLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPR--I 323
+ + G L L + D+G+Y C+ N +G K L V P T+E + G +
Sbjct: 357 KVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPP-TIEGAGGRPYVV 415
Query: 324 AAQIGDSVMLTCSVMGCESPSFSWRTQ-IDSPLSGKVRSEGTNSTLTLSPVSFENEHSYL 382
A G V L C G SP+ SW + + S + R E S L L + Y
Sbjct: 416 KAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYS 475
Query: 383 CTVT--CGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIEL 440
C + G L+ ++V++ P++ ++ GL VT P LE+
Sbjct: 476 CVASSPAGEAVLQYSVEVQV-----PPQLLVAEGL---GQVTTIVGQP-------LELPC 520
Query: 441 LKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAK-LHIDDMEFEPKQR 499
+ + I++L++ P E G + Q LHID +E +
Sbjct: 521 QASGSPVPTIQWLQNGR--------------PAEELAGVQVASQGTTLHIDHVELDHSGL 566
Query: 500 QSTQ-TLYVNVAPRDTTVLV----SPSSI----------LEEGSSVNMTC---------- 534
+ Q T A + V V +P + E SS C
Sbjct: 567 FACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGA 626
Query: 535 -----LSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSR 589
L +G+ +P LW P G S L + + D G+Y C N AG S+
Sbjct: 627 HPKPPLVEGWCSPGSLWGE--PTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESK 684
Query: 590 KEVELIIQVTPKDIKLTAFP-SESVKEGDTVIISCTCGNVPE---TWIILKKKAETGDTV 645
+EV L + V P + P +++V E +V + C VP +W + + V
Sbjct: 685 REVALKVLVPP---NIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGV 741
Query: 646 LKSIDG-AYTIRKAQLKDAGVYECESKNKVGS 676
S+DG I +AQL DAG Y C + N GS
Sbjct: 742 TVSVDGRVLRIEQAQLSDAGSYRCVASNVAGS 773
Score = 93.2 bits (230), Expect = 8e-19
Identities = 151/706 (21%), Positives = 264/706 (37%), Gaps = 85/706 (12%)
Query: 37 AQIGDSVSLTCSTTGCESPFFSWRTQIDS-PLNGKVTNEGTTSTLTMNPVSFGNEHSYLC 95
A + SVSL C +P +W + L +V T TL + + Y C
Sbjct: 1758 AILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTC 1817
Query: 96 TATCESRKLEKGIQVEIY---SFPKDPEIHLSGPLEA-----GKPITVKCSVADVYPFDR 147
A + + +K +Q+ + +F + P GP +A G + C D P
Sbjct: 1818 EALNAAGRDQKLVQLSVLVPPAFRQAPR----GPQDAVLVRVGDKAVLSCET-DALPEPT 1872
Query: 148 LEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSV 207
+ G L+ +Q + LE + +V+ D G + K+ ++V
Sbjct: 1873 VTW-YKDGQPLVLAQRTQALRGGQRLEIQEAQVS------DKG---LYSCKVSNVAGEAV 1922
Query: 208 PTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLD--NG 265
T V+ + +PK +S G + +TC G+PAP + W K
Sbjct: 1923 RTFTLTVQVPPTFENPKTETVSQ------VAGSPLVLTCDVSGVPAPTVTWLKDRMPVES 1976
Query: 266 NLQH--LSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRI 323
+ H +S L L ++ +G Y C N + RK+ F V + PRI
Sbjct: 1977 SAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKD---------FVVAVLVAPRI 2027
Query: 324 AAQ---------IGDSVMLTCSVMGCESPSFSWR---TQIDSPLSGKVRSEGTNSTLTLS 371
+ G V L C G P +W + + + +R +L L
Sbjct: 2028 RSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLK 2087
Query: 372 PVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEM----SGGLVN--GSSVTVSC 425
+ + +Y C H + ++ + P I+ SG LV+ G VT+ C
Sbjct: 2088 GLRASDAGAYTCVA---HNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVC 2144
Query: 426 KVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQA 485
V P+ + LK L L + +L ++ + + V +
Sbjct: 2145 PVRGSPPI---HVSWLKDGLPLP----LSQRTLLHGSGHTLRISKVQLADAGIFTCVAAS 2197
Query: 486 KLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKIL 545
+ D F TL V V P V ++ GS V + C ++G P P +
Sbjct: 2198 PAGVADRNF---------TLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVS 2248
Query: 546 WSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKL 605
W + Q L + +L L + DSG Y C +++AG +R+ +L + + P I+
Sbjct: 2249 WMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTV-MEPPHIED 2307
Query: 606 TAFPSE-SVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAG 664
+ P+E S+ G + + C P+ I K G + + + + R +++DAG
Sbjct: 2308 SGQPTELSLTPGAPMELLCDAQGTPQPNITWHK---DGQALTRLENNSRATRVLRVRDAG 2364
Query: 665 VYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLII 710
+Y C +++ G+ +S + VQ N P +V L++
Sbjct: 2365 LYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVL 2410
Score = 92.0 bits (227), Expect = 2e-18
Identities = 163/700 (23%), Positives = 247/700 (35%), Gaps = 112/700 (16%)
Query: 31 PESRYLAQI-GDSVSLTCSTTGCESPFFSW---RTQIDSP-LNGKVTNEGTTSTLTMNPV 85
P++ ++Q+ G + LTC +G +P +W R ++S ++G V+ G + P
Sbjct: 1938 PKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPA 1997
Query: 86 SFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEA-----GKPITVKCSVA 140
G +Y C A + K V + P+ I SG G+ + + C
Sbjct: 1998 QAG---TYTCVAENTQAEARKDFVVAVLVAPR---IRSSGVAREHHVLEGQEVRLDCEAD 2051
Query: 141 DVYPFDR--LEIDLLKGDHLMKSQEFLEDADRKSLETKSLE---------VTFTPVIEDI 189
P D L+ G + F D SL K L V P ED
Sbjct: 2052 GQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG--SLVLKGLRASDAGAYTCVAHNPAGED- 2108
Query: 190 GKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSE 249
A+LH + PT++Q T++S + G VTM C
Sbjct: 2109 -------ARLHTVNVLVPPTIKQGA-------DGSGTLVS-------RPGELVTMVCPVR 2147
Query: 250 GLPAPEIFWSKK-----LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV 304
G P + W K L L H SG+ TL + +++ D+GI+ C + G +
Sbjct: 2148 GSPPIHVSWLKDGLPLPLSQRTLLHGSGH-TLRISKVQLADAGIFTCVAASPAGVADRNF 2206
Query: 305 ELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGT 364
L VQ P + + G V L C G P SW PL + +G
Sbjct: 2207 TLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKD-GEPLLSQSLEQGP 2265
Query: 365 NSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSG-----GLVNGS 419
+ L L V + +Y C + + Q+ + P IE SG L G+
Sbjct: 2266 S--LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVME---PPHIEDSGQPTELSLTPGA 2320
Query: 420 SVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTD-MKSLENKSLEMTFIPTIEDTG 478
+ + C T NI + +D + LEN S T + + D G
Sbjct: 2321 PMELLCDAQG---------------TPQPNITWHKDGQALTRLENNS-RATRVLRVRDAG 2364
Query: 479 KALVCQAKLHIDDMEFEPKQR-QSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQ 537
C A+ +E + R Q+ + PR L +LE C +
Sbjct: 2365 -LYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLE--------CSVE 2415
Query: 538 GFPAPKILWSRQ----LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVE 593
PAPKI W R + Q L L + DSG Y C N AG +
Sbjct: 2416 AEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 2475
Query: 594 LIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSID--- 650
+ I P + P+ +V T ++ C VP + +K D +
Sbjct: 2476 VEIHTVPTI--RSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILP 2533
Query: 651 -GAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRE 689
G+ I+ +DAG Y C + N GS D QGR+
Sbjct: 2534 EGSLRIQPVLAQDAGHYLCLASNSAGS-------DRQGRD 2566
Score = 91.3 bits (225), Expect = 3e-18
Identities = 108/426 (25%), Positives = 169/426 (39%), Gaps = 53/426 (12%)
Query: 283 MEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGD-SVMLTCSVMGCE 341
+ D GIY C NL G++++EV L V P I PGP A + + SV L C G
Sbjct: 666 LRDEGIYTCAATNLAGESKREVALKVLVPP---NIEPGPVNKAVLENASVTLECLASGVP 722
Query: 342 SPSFSW---RTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVT--CGHKKLEKGI 396
P SW + S + V +G L + + SY C + G +L G+
Sbjct: 723 PPDVSWFKGHQPVSSWMGVTVSVDGR--VLRIEQAQLSDAGSYRCVASNVAGSTELRYGL 780
Query: 397 QVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDT 456
+V + P + G ++ + V ++C T++ +L+D
Sbjct: 781 RVNVPPRITLPP-SLPGPVLVNTPVRLTCNATGA-----------PSPTLM----WLKDG 824
Query: 457 DMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFE-------PKQRQSTQTLYVNV 509
+ S F G+ L + D + + RQ L V++
Sbjct: 825 NPVSPAGTPGLQVF-----PGGRVLTLASARASDSGRYSCVAVSAVGEDRQDV-VLQVHM 878
Query: 510 APRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILW---SRQL-PNGELQPLSENATLT 565
P ++ S + E SV + C S P P + W R L P + ++ A L
Sbjct: 879 PPSILGEELNVSVVANE--SVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQ 936
Query: 566 LISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTC 625
+ + D+G Y CE +NQAGRS K L + V P L + +V+EG +SC C
Sbjct: 937 VDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPV-FPLRESHTLTVREGHPTSLSCEC 995
Query: 626 GNVPETWIILKKKAE------TGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLR 679
VP I +K + G + ++ + +AQL G Y CE N VG+ +
Sbjct: 996 RGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQ 1055
Query: 680 SLTLDV 685
L L+V
Sbjct: 1056 DLQLEV 1061
Score = 84.7 bits (208), Expect = 3e-16
Identities = 109/483 (22%), Positives = 181/483 (37%), Gaps = 59/483 (12%)
Query: 239 GGSVTMTCSSEGLPAPEIFWSKK----LDNG-NLQHLSGNATLTLIAMRMEDSGIYVCEG 293
G V + C + G+P P++ W+K L G +LQ L + + D G Y C
Sbjct: 232 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVA 291
Query: 294 VNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSW-RTQID 352
+ G+ ++ +L V P + +A V L C G +P+ +W +
Sbjct: 292 FSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGAL 351
Query: 353 SPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMS 412
P S KV L L + Y C + EK ++++Y P IE +
Sbjct: 352 LPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV---PPTIEGA 408
Query: 413 GG------LVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSL 466
GG V G V + C V +P L +G + E+ E +TD L +S
Sbjct: 409 GGRPYVVKAVAGRPVALEC-VARGHPSPTLSWHH-EGLPVAESNESRLETDGSVLRLES- 465
Query: 467 EMTFIPTIEDTGK-ALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILE 525
P +G + V + +++ + + Q L + TT++
Sbjct: 466 -----PGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIV-------- 512
Query: 526 EGSSVNMTCLSQGFPAPKILWSRQLPNGE-------LQPLSENATLTLISTKMEDSGVYL 578
G + + C + G P P I W L NG +Q S+ TL + +++ SG++
Sbjct: 513 -GQPLELPCQASGSPVPTIQW---LQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFA 568
Query: 579 CEGINQAGRSRKEVELII--QVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILK 636
C+ N+AG + EVE+ + + P +++ E + + V W
Sbjct: 569 CQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHP 628
Query: 637 KK--------------AETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLT 682
K TG V S+ I K L+D G+Y C + N G R +
Sbjct: 629 KPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVA 688
Query: 683 LDV 685
L V
Sbjct: 689 LKV 691
Score = 83.6 bits (205), Expect = 6e-16
Identities = 130/583 (22%), Positives = 214/583 (36%), Gaps = 80/583 (13%)
Query: 43 VSLTCSTTGCESPFFSWR---TQIDSPLNG-KVTNEGTTSTLTMNPVSFGNEHSYLCTAT 98
V LTC +TG +P SW Q+ + +G +V+ G P+ G Y C+A
Sbjct: 2683 VVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGR---YTCSAR 2739
Query: 99 CESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHL 158
+ K + + + + P + A + + + C + + R I K
Sbjct: 2740 NSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGI---PRPTITWQK---- 2792
Query: 159 MKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQ 218
+ + L L + ED G L C AK + A+ + +
Sbjct: 2793 -EGLNVATGVSTQVLPGGQLRIAHASP-EDAGNYL-CIAK---------NSAGSAMGKTR 2840
Query: 219 VYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATL-- 276
+ + + + P EG + C + G P P I W K D + G T+
Sbjct: 2841 LVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDK--DGQPVSGAEGKFTIQP 2898
Query: 277 --TLIAMRME--DSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVM 332
L+ +E D+G Y C N +G+ R+ V L + P + PG R + ++GD +
Sbjct: 2899 SGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTL-PGDR-SLRLGDRLW 2956
Query: 333 LTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLC--------- 383
L C+ G +P W T D P++ V + STL + VS E+ +Y+C
Sbjct: 2957 LRCAARGSPTPRIGW-TVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRT 3015
Query: 384 -TVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLK 442
V+ H K +Q E +S+ +E GG + V VP ++
Sbjct: 3016 QAVSFVHVKEAPVLQGEAFSY----LVEPVGGSIQLDCVVRGDPVPDIH----------- 3060
Query: 443 GETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQST 502
I + + L+N SL T T D C A E E +
Sbjct: 3061 --WIKDGLPLRGSHLRHQLQNGSL--TIHRTERDDAGRYQCLA-------ENEMGVAKKV 3109
Query: 503 QTLYVNVAPRDTTVLVSPSSI-LEEGSSVNMTCLSQGFPAPKILW---SRQLPNGELQPL 558
L + AP V P + + G V + C + G P P I W + L
Sbjct: 3110 VILVLQSAP---VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRT 3166
Query: 559 SENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPK 601
+ +L L + + D+G Y C N G + L+++ P+
Sbjct: 3167 LPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQ 3209
Score = 82.4 bits (202), Expect = 1e-15
Identities = 143/686 (20%), Positives = 255/686 (37%), Gaps = 71/686 (10%)
Query: 28 ETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSF 87
E + + + + +SL C SP +W +P + T + ++
Sbjct: 1353 EDSADEEVTVTVNNPISLICEALAFPSPNITWMKD-GAPFEASRNIQLLPGTHGLQILNA 1411
Query: 88 GNEHS--YLCTATCESRKLEKGIQVEIY---SFPKDPEIHLSGPLEA----GKPITVKC- 137
E + Y C T E + K VE+ S KD + G E +T++C
Sbjct: 1412 QKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECE 1471
Query: 138 SVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRA 197
S A P R D G + S + + L+ + +V+ D G+ L
Sbjct: 1472 SWAVPPPTIRWYKD---GQPVTPSSRLQVLGEGRLLQIQPTQVS------DSGRYLCVAT 1522
Query: 198 KLH-IDEMD-----SVPTVRQAVKEL----QVYISPKNTVISVNPSTKLQEGGSVTMTCS 247
+ D+ D VP + Q V + ++ + V ++ E + C
Sbjct: 1523 NVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCD 1582
Query: 248 SEGLPAPEIFWSKK---LDNGN-LQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKE 303
+ +P P++ W ++ L G+ + L G L + +R E++G Y C+ N +G++
Sbjct: 1583 TNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLH 1642
Query: 304 VELIVQEKPFTVEISPG--PRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRS 361
EL+V P + + + +V L C +G P+ SW Q P S R
Sbjct: 1643 YELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISW-LQNGLPFSPSPRL 1701
Query: 362 E--GTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDP--EIEMSGGLVN 417
+ L +S + SY+C EK + + PR ++E ++N
Sbjct: 1702 QVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILN 1761
Query: 418 GSSVTVSCKVPSVYPLDRLEIELLKGETIL---ENIEFLEDTDMKSLENKSLEMTFIPTI 474
SSV++ C V+ E+ K L E + L T L L + + T
Sbjct: 1762 -SSVSLPC---DVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTC 1817
Query: 475 EDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTC 534
E A Q + + + P RQ+ + P+D ++ G ++C
Sbjct: 1818 EALNAAGRDQKLVQLSVL-VPPAFRQAPR------GPQDAV-------LVRVGDKAVLSC 1863
Query: 535 LSQGFPAPKILWSRQ----LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRK 590
+ P P + W + + Q L L + ++ D G+Y C+ N AG + +
Sbjct: 1864 ETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVR 1923
Query: 591 EVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWIILKKKAETGDT-VL 646
L +QV P + + S G ++++C VP TW+ + E+ +
Sbjct: 1924 TFTLTVQV-PPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGV 1982
Query: 647 KSIDGAYTIRKAQLKDAGVYECESKN 672
S G + + Q AG Y C ++N
Sbjct: 1983 VSRGGRLQLSRLQPAQAGTYTCVAEN 2008
Score = 82.0 bits (201), Expect = 2e-15
Identities = 138/688 (20%), Positives = 257/688 (37%), Gaps = 75/688 (10%)
Query: 44 SLTCSTTGCESPFFSWRTQ---IDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCE 100
+L C+ TG P +W + + L ++ N+G +L + + Y C A
Sbjct: 1086 TLECNATGKPPPTVTWERDGQPVGAELGLQLQNQG--QSLHVERAQAAHTGRYSCVAENL 1143
Query: 101 SRKLEKGIQVEIYSFPK-----DPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKG 155
+ + E+ ++ + P+ DP +++ L + P+T+ C + P
Sbjct: 1144 AGRAERKFELSVLVPPELIGDLDPLTNITAALHS--PLTLLCEAMGIPP---------PA 1192
Query: 156 DHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVK 215
+ +E + + L + T E + C A E +V
Sbjct: 1193 IRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSV----- 1247
Query: 216 ELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSK---KLDNGNLQHLSG 272
+V + P + K+ +G + + C+ G P P++ W K L G+ H+S
Sbjct: 1248 --EVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISP 1305
Query: 273 NAT-LTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTV---EISPGPRIAAQIG 328
+ L ++ + +G Y C N +G+ K +L V P + E S + +
Sbjct: 1306 DGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVN 1365
Query: 329 DSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHS--YLCTVT 386
+ + L C + SP+ +W +P + T L ++ + E + Y C VT
Sbjct: 1366 NPISLICEALAFPSPNITWMKD-GAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVT 1424
Query: 387 CGHKKLEKGIQVELYSFPR----DPEIEMSGGLVN---GSSVTVSCKVPSVYPLDRLEIE 439
+ K VE+ P DP E+ V S++T+ C+ +V P +
Sbjct: 1425 NELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYK 1484
Query: 440 LLKGETILENIEFLEDTDMKSLENKSLEMTFIPT-IEDTGKAL-VCQAKLHIDDMEFEPK 497
+ T ++ L + + ++ PT + D+G+ L V DD +F
Sbjct: 1485 DGQPVTPSSRLQVLGEGRLLQIQ---------PTQVSDSGRYLCVATNVAGEDDQDFNVL 1535
Query: 498 -------QRQSTQTLYVNVAPRDTTVL--VSPSSILEEGSSVNMTCLSQGFPAPKILWSR 548
Q+ + + R+ V+ + E + + C + P P + W R
Sbjct: 1536 IQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYR 1595
Query: 549 Q----LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIK 604
+ E+ L L + + E++G Y C+ N+ G EL++ P +
Sbjct: 1596 EDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILG 1655
Query: 605 LTAFPSESVKEGDTVIISCTC---GN-VPE-TWIILKKKAETGDTVLKSIDG-AYTIRKA 658
T E V + +S C GN VP +W+ + DG + A
Sbjct: 1656 DTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTA 1715
Query: 659 QLKDAGVYECESKNKVGSQLRSLTLDVQ 686
++ DA Y C ++N+ GS + TL VQ
Sbjct: 1716 EVADAASYMCVAENQAGSAEKLFTLRVQ 1743
Score = 79.0 bits (193), Expect = 2e-14
Identities = 113/497 (22%), Positives = 194/497 (39%), Gaps = 58/497 (11%)
Query: 217 LQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLD-----NGNLQHLS 271
L+V + P VN + + E SVT+ C + G+P P++ W K G +
Sbjct: 689 LKVLVPPNIEPGPVNKA--VLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVD 746
Query: 272 GNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKP-FTVEIS-PGPRIAAQIGD 329
G L + ++ D+G Y C N+ G L V P T+ S PGP + +
Sbjct: 747 GR-VLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVL---VNT 802
Query: 330 SVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGT--------NSTLTLSPVSFENEHSY 381
V LTC+ G SP+ W V GT LTL+ + Y
Sbjct: 803 PVRLTCNATGAPSPTLMWLKD-----GNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 857
Query: 382 LCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELL 441
C + + + ++++ P E++ +V SV + C+ ++ P
Sbjct: 858 SCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPP--------- 908
Query: 442 KGETILENIEFLEDTDMKSLENK-SLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQ 500
+L + D + LE + + ++ + +A V A + + + + +
Sbjct: 909 ---PVLSWWK-----DGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSE 960
Query: 501 STQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQ---LP--NGEL 555
L V VAP + S + + EG +++C +G P PKI W + LP L
Sbjct: 961 KHYNLNVWVAP-VFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGL 1019
Query: 556 QPLSE-NATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSE-SV 613
Q +S L L ++ G Y CE N G S ++++L + V P+ P++ SV
Sbjct: 1020 QHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSV 1079
Query: 614 KEGDTVIISCTCGNVPETWIILKKK-----AETGDTVLKSIDGAYTIRKAQLKDAGVYEC 668
+ + C P + ++ AE G L++ + + +AQ G Y C
Sbjct: 1080 VQDGVATLECNATGKPPPTVTWERDGQPVGAELG-LQLQNQGQSLHVERAQAAHTGRYSC 1138
Query: 669 ESKNKVGSQLRSLTLDV 685
++N G R L V
Sbjct: 1139 VAENLAGRAERKFELSV 1155
Score = 68.2 bits (165), Expect = 3e-11
Identities = 152/728 (20%), Positives = 260/728 (35%), Gaps = 95/728 (13%)
Query: 36 LAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNG----KVTNEGTTSTLTMNPVSFGNEH 91
L G V L C T+G +P W L G +V +G +T + V G+E
Sbjct: 228 LGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHV--GDEG 285
Query: 92 SYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEID 151
Y C A + + + Q+ +++ P + G E G+ ++ D L +
Sbjct: 286 RYQCVAFSPAGQQARDFQLRVHAPPT-----IWGSNETGEVAVME---------DHL-VQ 330
Query: 152 LLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIE--DIGKVLVCRAKLHIDEMDSVPT 209
LL + + D L T S +V +T +G+ A ++ + +
Sbjct: 331 LLCEARGVPTPNITWFKDGALLPT-STKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVG 389
Query: 210 VRQAVKELQVYISPKNTVISVNP-STKLQEGGSVTMTCSSEGLPAPEIFWSKK----LDN 264
+ L VY+ P P K G V + C + G P+P + W + ++
Sbjct: 390 AAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAES 449
Query: 265 GNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIA 324
+ + + L L + SG+Y C + G+ + + VQ P + ++
Sbjct: 450 NESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVT 509
Query: 325 AQIGDSVMLTCSVMGCESPSFSW--RTQIDSPLSG-KVRSEGTNSTLTLSPVSFENEHSY 381
+G + L C G P+ W + L+G +V S+GT TL + V ++ +
Sbjct: 510 TIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGT--TLHIDHVELDHSGLF 567
Query: 382 LCTVT--CGHKKLEKGIQVELYSFPRDPEI---EMSGGLVNGSSVTVSCKVP-----SVY 431
C T G E + V P E+ + G + SS +C P +
Sbjct: 568 ACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAH 627
Query: 432 PLDRL-----EIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAK 486
P L L GE + + ++ +E L I T T L ++K
Sbjct: 628 PKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQ-IEKVDLRDEGIYTCAATN--LAGESK 684
Query: 487 LHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILW 546
+ P + P + VL + S LE CL+ G P P + W
Sbjct: 685 REVALKVLVPPN--------IEPGPVNKAVLENASVTLE--------CLASGVPPPDVSW 728
Query: 547 SRQLPNGELQPLS---------ENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQ 597
+ QP+S + L + ++ D+G Y C N AG + L +
Sbjct: 729 FK-----GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVN 783
Query: 598 VTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKK----AETGDTVLKSIDG-- 651
V P+ + P V V ++C P ++ K + G L+ G
Sbjct: 784 VPPRITLPPSLPG-PVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGR 842
Query: 652 AYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ------GRENNKDYFSPELLVLYFA 705
T+ A+ D+G Y C + + VG + + L V G E N + E + L
Sbjct: 843 VLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQ 902
Query: 706 SSLIIPAI 713
S + P +
Sbjct: 903 SHAMPPPV 910
Score = 51.2 bits (121), Expect = 3e-06
Identities = 32/117 (27%), Positives = 47/117 (40%), Gaps = 10/117 (8%)
Query: 236 LQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLT-----LIAMRMEDSGIYV 290
L+ GG C + G P P++ W K + L G A L L ++ DSG Y
Sbjct: 19 LEAGG-----CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYE 73
Query: 291 CEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSW 347
C+ N +G + +L+V P E ++ G S+ L C G P W
Sbjct: 74 CQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVW 130
Score = 50.4 bits (119), Expect = 6e-06
Identities = 75/305 (24%), Positives = 120/305 (39%), Gaps = 59/305 (19%)
Query: 29 TTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFG 88
T P R L ++GD + L C+ G +P W T D P+ V+ + STL VS
Sbjct: 2942 TLPGDRSL-RLGDRLWLRCAARGSPTPRIGW-TVNDRPVTEGVSEQDGGSTLQRAAVSRE 2999
Query: 89 NEHSYLCTATCESR------------KLEKGIQVEIYSFPKDPEIHLSGPLEA-----GK 131
+ +Y+C A E+R K +Q E +S+ +P + G ++ G
Sbjct: 3000 DSGTYVCWA--ENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEP---VGGSIQLDCVVRGD 3054
Query: 132 PITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGK 191
P+ + D P L+G HL R L+ SL + T +D G+
Sbjct: 3055 PVPDIHWIKDGLP--------LRGSHL-----------RHQLQNGSLTIHRTER-DDAGR 3094
Query: 192 VLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTK-LQEGGSVTMTCSSEG 250
C A+ +EM K++ + + V V P ++ G V + C + G
Sbjct: 3095 YQ-CLAE---NEMG-------VAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATG 3143
Query: 251 LPAPEIFW---SKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELI 307
P P I W + L + +L L + D+G Y C NL+G L+
Sbjct: 3144 EPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLV 3203
Query: 308 VQEKP 312
V+ +P
Sbjct: 3204 VRGEP 3208
Score = 45.4 bits (106), Expect = 2e-04
Identities = 31/113 (27%), Positives = 52/113 (46%), Gaps = 7/113 (6%)
Query: 534 CLSQGFPAPKILWSRQLPNGEL---QP---LSENATLTLISTKMEDSGVYLCEGINQAGR 587
C + G P P++ W R+ P+ E QP + E +L L S DSG Y C+ N+ G
Sbjct: 24 CGTHGTPKPQVTW-RKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGS 82
Query: 588 SRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAE 640
+ + +L++ V P + + S G ++ + C P I+ K A+
Sbjct: 83 TSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQ 135
Score = 32.7 bits (73), Expect = 1.2
Identities = 15/45 (33%), Positives = 21/45 (46%)
Query: 216 ELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSK 260
+L VY+ P + G S+T+ C + G P PEI W K
Sbjct: 88 KLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLK 132
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 103 bits (258), Expect = 4e-22
Identities = 126/500 (25%), Positives = 210/500 (42%), Gaps = 76/500 (15%)
Query: 235 KLQEGGSVTMTCSSEGLPAPEIFWSKK----LDNGNLQHLSGNATLTLIAMRMEDSGIYV 290
K + ++T+ C S +P P I W K + LQ L L + ++ DSG Y+
Sbjct: 1368 KTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYL 1427
Query: 291 CEGVNLIGKNRKEVELIVQEKPFTVEISP----------------GPRIAAQIGDS--VM 332
C N+ G++ ++ +++Q P ++ G +I ++
Sbjct: 1428 CVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAY 1487
Query: 333 LTCSVMGCESPSFSWRTQIDSPLSG--KVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHK 390
L C P +W + D PLS +V L + V EN Y C + ++
Sbjct: 1488 LYCDTNAIPPPDLTWYRE-DQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKAS--NE 1544
Query: 391 KLEKGIQVELYSFPR-----DPEIEMSGGLVNGSSVTVSCKVPSV-YPLDRLEIELLKGE 444
E + EL D E + VN SS TVS + P++ P+ +
Sbjct: 1545 VGEDWLHYELLVLTPPVILGDTEELVEEVTVNASS-TVSLQCPALGNPVPTIS------- 1596
Query: 445 TILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQT 504
+ + F ++ LE+ + + D + +C A E + + T
Sbjct: 1597 WLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAA-SYMCVA-------ENQAGSAEKLFT 1648
Query: 505 LYVNVAPRDTTV-LVSPSSILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGE-LQPLS 559
L V V PR + L ++IL SSV++ C P P++ W S+ L GE + L
Sbjct: 1649 LRVQVPPRIAGLDLEQVTAILN--SSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLP 1706
Query: 560 ENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSES--VKEGD 617
TL L ++ DSG+Y CE +N AGR +K V+L + V P + P ++ V+ GD
Sbjct: 1707 GTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGD 1766
Query: 618 TVIISCTCGNVPE---TW------IILKKKAET--GDTVLKSIDGAYTIRKAQLKDAGVY 666
++SC +PE TW ++L ++ + G L+ I++AQ+ D G+Y
Sbjct: 1767 KAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLE-------IQEAQVSDKGLY 1819
Query: 667 ECESKNKVGSQLRSLTLDVQ 686
C+ N G +R+ TL VQ
Sbjct: 1820 SCKVSNVAGEAVRTFTLTVQ 1839
Score = 102 bits (254), Expect = 1e-21
Identities = 159/682 (23%), Positives = 251/682 (36%), Gaps = 88/682 (12%)
Query: 42 SVSLTCSTTGCESPFFSW---RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTAT 98
SV+L C +G P SW + S + V+ +G L + + SY C A+
Sbjct: 620 SVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV--LRIEQAQLSDAGSYRCVAS 677
Query: 99 --CESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGD 156
S +L G++V + P L GP+ P+ + C+
Sbjct: 678 NVAGSTELRYGLRVNVPPRITLPP-SLPGPVLVNTPVRLTCNATGA-----------PSP 725
Query: 157 HLMKSQEFLEDADRKS-LETKSLEVTFTPVIEDIGKVLVCRAKLHIDE-------MDSVP 208
LM +L+D + S T L+V G+VL + D + +V
Sbjct: 726 TLM----WLKDGNPVSPAGTPGLQVF------PGGRVLTLASARASDSGRYSCVAVSAVG 775
Query: 209 TVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK---LDNG 265
RQ V LQV++ P +N S E SV + C S +P P + W K L+
Sbjct: 776 EDRQDVV-LQVHMPPSILGEELNVSVVANE--SVALECQSHAMPPPVLSWWKDGRPLEPR 832
Query: 266 NLQHLSGN-ATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIA 324
HLS + A L + + D+G Y CE +N G + K L V P + +
Sbjct: 833 PGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAP-VFPLRESHTLT 891
Query: 325 AQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRS----EGTNSTLTLSPVSFENEHS 380
+ G L+C G P SWR PL G+ L L E +
Sbjct: 892 VREGHPTRLSCECRGVPFPKISWRKD-GQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGT 950
Query: 381 YLCTVTCGHKKLEKGIQVELY-----SFPRDPEIEMSGGLVNGSSVTVSC----KVPSVY 431
Y C + + +Q+E++ + PR+P ++S +V T+ C K P
Sbjct: 951 YTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVS--VVQDGVATLECNATGKPPPTV 1008
Query: 432 PLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDD 491
+R G+ + + +SL + + + L +A+ +
Sbjct: 1009 TWER------DGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFEL 1062
Query: 492 MEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQ-- 549
P + N+ T L SP ++L C + G P P I W R
Sbjct: 1063 SVLVPPELIGDLDPLTNI----TAALHSPLTLL---------CEAMGIPPPAIRWFRGEE 1109
Query: 550 --LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTA 607
P + L+ L + T+ +DSG+Y C N+AG +R+ + + V P
Sbjct: 1110 PVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDL 1169
Query: 608 FPSESVKEGDTVIISCTCGNVPE---TWIILKKKAETGDTVLKSIDGA-YTIRKAQLKDA 663
V +G T + C P+ TW + GD S DG + +A L A
Sbjct: 1170 EEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSA 1229
Query: 664 GVYECESKNKVGSQLRSLTLDV 685
G Y C + N VG + + L V
Sbjct: 1230 GHYSCIAANAVGEKTKHFQLSV 1251
Score = 100 bits (250), Expect = 4e-21
Identities = 159/675 (23%), Positives = 257/675 (38%), Gaps = 88/675 (13%)
Query: 40 GDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATC 99
G V L C G P SW PL + +G + L + V G+ +Y C A
Sbjct: 2139 GSLVELPCEARGVPLPLVSWMKD-GEPLLSQSLEQGPS--LQLEAVGAGDSGTYSCVAVS 2195
Query: 100 ESRKLEKGIQVEIYSFPKDPEIHLSGP-----LEAGKPITVKCSVADVYPFDRLEIDLLK 154
E+ + + Q+ + + P I SG L G P+ + C A P +
Sbjct: 2196 EAGEARRHFQLTVM---EPPHIEDSGQPTELSLTPGAPMELLCD-AQGTPQPNITWH--- 2248
Query: 155 GDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAV 214
K + L + S T+ L V D G + C A+ ++ VR
Sbjct: 2249 -----KDGQALTRLENNSRATRVLRV------RDAG-LYTCLAESPAGAIEKSFRVRVQA 2296
Query: 215 KELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK----LDNGNLQHL 270
V V+ + P G + + CS E PAP+I W + ++ + Q
Sbjct: 2297 PPNIVGPRGPRFVVGLAP-------GQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFP 2349
Query: 271 SGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDS 330
L L A+ DSG Y C N G + + P T+ P P + + +
Sbjct: 2350 ERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVP-TIRSGP-PAVNVSVNQT 2407
Query: 331 VMLTCSVMGCESPSFSWRTQIDSPLSGK-----VRSEGTNSTLTLSPVSFENEHSYLCTV 385
+L C G +P SWR PL + + EG+ L + PV ++ YLC
Sbjct: 2408 ALLPCQADGVPAPLVSWRKD-RVPLDPRSPRFEILPEGS---LRIQPVLAQDAGHYLCLA 2463
Query: 386 TCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDR------LEIE 439
+ +G + + P I S S++T++ P++ P + L +
Sbjct: 2464 SNSAGSDRQGRDLRVLE---PPAIAPSP-----SNLTLTAHTPALLPCEASGSPKPLVVW 2515
Query: 440 LLKGETILENIEF-LEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQ 498
G+ ++F L+ + L + +L +T P +D+ + C + + +
Sbjct: 2516 WKDGQ----KLDFRLQQGAYRLLPSNALLLT-APGPQDSAQ-FECVVSNEVGEAH---RL 2566
Query: 499 RQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSR---QL-PNGE 554
Q T + +A T V+ + V +TC S G PAP + WS+ QL G
Sbjct: 2567 YQVTVHVPPTIADDQTDFTVTMMA------PVVLTCHSTGIPAPTVSWSKAGAQLGARGS 2620
Query: 555 LQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVK 614
+S + L + +G Y C N AG + K V L +Q +P +K +V
Sbjct: 2621 GYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPV-VKPLPSVVRAVA 2679
Query: 615 EGDTVIISCTCGNVPETWIILKKK---AETGDTVLKSIDGAYTIRKAQLKDAGVYECESK 671
E + V++ C +P I +K+ TG + G I A +DAG Y C +K
Sbjct: 2680 E-EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAK 2738
Query: 672 NKVGSQLRSLTLDVQ 686
N GS + L VQ
Sbjct: 2739 NSAGSAMGKTRLVVQ 2753
Score = 98.6 bits (244), Expect = 2e-20
Identities = 106/465 (22%), Positives = 184/465 (39%), Gaps = 51/465 (10%)
Query: 242 VTMTCSSEGLPAPEIFWSKK---LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIG 298
V + C + G+P P I W K+ + G + L + ED+G Y+C N G
Sbjct: 2683 VLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAG 2742
Query: 299 KNRKEVELIVQEKPFTVEISPG-PRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSG 357
+ L+VQ P I G P ++ G L C G P+ +W P+SG
Sbjct: 2743 SAMGKTRLVVQVPPV---IENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKD-GQPVSG 2798
Query: 358 KVRSEGT-----NSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMS 412
+EG + L + + ++ +Y CT + + + + + P +
Sbjct: 2799 ---AEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGD 2855
Query: 413 GGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIP 472
L G + + C P R+ + + E + E +L+ ++
Sbjct: 2856 RSLRLGDRLWLRCAARGS-PTPRIGWTV-NDRPVTEGVS--EQDGGSTLQRAAVSR---- 2907
Query: 473 TIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAP----RDTTVLVSPSSILEEGS 528
ED+G VC A+ + + Q+ ++V AP + LV P G
Sbjct: 2908 --EDSG-TYVCWAENRVG-------RTQAVSFVHVKEAPVLQGEAFSYLVEPV-----GG 2952
Query: 529 SVNMTCLSQGFPAPKILWSRQ---LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQA 585
S+ + C+ +G P P I W + L L+ +N +LT+ T+ +D+G Y C N+
Sbjct: 2953 SIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEM 3012
Query: 586 GRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWIILKKKAETG 642
G ++K V L++Q P + +V+ GD V + C P W+ +
Sbjct: 3013 GVAKKVVILVLQSAP--VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRAS 3070
Query: 643 DTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQG 687
+ DG+ + + DAG Y+C + N +GS L V+G
Sbjct: 3071 RRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRG 3115
Score = 94.7 bits (234), Expect = 3e-19
Identities = 125/512 (24%), Positives = 197/512 (38%), Gaps = 82/512 (16%)
Query: 212 QAVKELQVYISPKNTVISVNPSTKL--QEGGSVTMTCSSEGLPAPEIFWSKK----LDNG 265
Q ++ Q+ + T+ N + ++ E V + C + G+P P I W K +
Sbjct: 206 QQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTST 265
Query: 266 NLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPR--I 323
+ + G L L + D+G+Y C+ N +G K L V P T+E + G +
Sbjct: 266 KVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPP-TIEGAGGRPYVV 324
Query: 324 AAQIGDSVMLTCSVMGCESPSFSWRTQ-IDSPLSGKVRSEGTNSTLTLSPVSFENEHSYL 382
A G V L C G SP+ SW + + S + R E S L L + Y
Sbjct: 325 KAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYS 384
Query: 383 CTVT--CGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIEL 440
C + G L+ ++V++ P++ ++ GL VT P LE+
Sbjct: 385 CVASSPAGEAVLQYSVEVQV-----PPQLLVAEGL---GQVTTIVGQP-------LELPC 429
Query: 441 LKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAK-LHIDDMEFEPKQR 499
+ + I++L++ P E G + Q LHID +E +
Sbjct: 430 QASGSPVPTIQWLQNGR--------------PAEELAGVQVASQGTTLHIDHVELDHSGL 475
Query: 500 QSTQ-TLYVNVAPRDTTVLV----SPSSI----------LEEGSSVNMTC---------- 534
+ Q T A + V V +P + E SS C
Sbjct: 476 FACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGA 535
Query: 535 -----LSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSR 589
L +G+ +P LW P G S L + + D G+Y C N AG S+
Sbjct: 536 HPKPPLVEGWCSPGSLWGE--PTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESK 593
Query: 590 KEVELIIQVTPKDIKLTAFP-SESVKEGDTVIISCTCGNVPE---TWIILKKKAETGDTV 645
+EV L + V P + P +++V E +V + C VP +W + + V
Sbjct: 594 REVALKVLVPP---NIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGV 650
Query: 646 LKSIDG-AYTIRKAQLKDAGVYECESKNKVGS 676
S+DG I +AQL DAG Y C + N GS
Sbjct: 651 TVSVDGRVLRIEQAQLSDAGSYRCVASNVAGS 682
Score = 93.2 bits (230), Expect = 8e-19
Identities = 151/706 (21%), Positives = 264/706 (37%), Gaps = 85/706 (12%)
Query: 37 AQIGDSVSLTCSTTGCESPFFSWRTQIDS-PLNGKVTNEGTTSTLTMNPVSFGNEHSYLC 95
A + SVSL C +P +W + L +V T TL + + Y C
Sbjct: 1667 AILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTC 1726
Query: 96 TATCESRKLEKGIQVEIY---SFPKDPEIHLSGPLEA-----GKPITVKCSVADVYPFDR 147
A + + +K +Q+ + +F + P GP +A G + C D P
Sbjct: 1727 EALNAAGRDQKLVQLSVLVPPAFRQAPR----GPQDAVLVRVGDKAVLSCET-DALPEPT 1781
Query: 148 LEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSV 207
+ G L+ +Q + LE + +V+ D G + K+ ++V
Sbjct: 1782 VTW-YKDGQPLVLAQRTQALRGGQRLEIQEAQVS------DKG---LYSCKVSNVAGEAV 1831
Query: 208 PTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLD--NG 265
T V+ + +PK +S G + +TC G+PAP + W K
Sbjct: 1832 RTFTLTVQVPPTFENPKTETVSQ------VAGSPLVLTCDVSGVPAPTVTWLKDRMPVES 1885
Query: 266 NLQH--LSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRI 323
+ H +S L L ++ +G Y C N + RK+ F V + PRI
Sbjct: 1886 SAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKD---------FVVAVLVAPRI 1936
Query: 324 AAQ---------IGDSVMLTCSVMGCESPSFSWR---TQIDSPLSGKVRSEGTNSTLTLS 371
+ G V L C G P +W + + + +R +L L
Sbjct: 1937 RSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLK 1996
Query: 372 PVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEM----SGGLVN--GSSVTVSC 425
+ + +Y C H + ++ + P I+ SG LV+ G VT+ C
Sbjct: 1997 GLRASDAGAYTCVA---HNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVC 2053
Query: 426 KVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQA 485
V P+ + LK L L + +L ++ + + V +
Sbjct: 2054 PVRGSPPI---HVSWLKDGLPLP----LSQRTLLHGSGHTLRISKVQLADAGIFTCVAAS 2106
Query: 486 KLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKIL 545
+ D F TL V V P V ++ GS V + C ++G P P +
Sbjct: 2107 PAGVADRNF---------TLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVS 2157
Query: 546 WSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKL 605
W + Q L + +L L + DSG Y C +++AG +R+ +L + + P I+
Sbjct: 2158 WMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTV-MEPPHIED 2216
Query: 606 TAFPSE-SVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAG 664
+ P+E S+ G + + C P+ I K G + + + + R +++DAG
Sbjct: 2217 SGQPTELSLTPGAPMELLCDAQGTPQPNITWHK---DGQALTRLENNSRATRVLRVRDAG 2273
Query: 665 VYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLII 710
+Y C +++ G+ +S + VQ N P +V L++
Sbjct: 2274 LYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVL 2319
Score = 92.0 bits (227), Expect = 2e-18
Identities = 163/700 (23%), Positives = 247/700 (35%), Gaps = 112/700 (16%)
Query: 31 PESRYLAQI-GDSVSLTCSTTGCESPFFSW---RTQIDSP-LNGKVTNEGTTSTLTMNPV 85
P++ ++Q+ G + LTC +G +P +W R ++S ++G V+ G + P
Sbjct: 1847 PKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPA 1906
Query: 86 SFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEA-----GKPITVKCSVA 140
G +Y C A + K V + P+ I SG G+ + + C
Sbjct: 1907 QAG---TYTCVAENTQAEARKDFVVAVLVAPR---IRSSGVAREHHVLEGQEVRLDCEAD 1960
Query: 141 DVYPFDR--LEIDLLKGDHLMKSQEFLEDADRKSLETKSLE---------VTFTPVIEDI 189
P D L+ G + F D SL K L V P ED
Sbjct: 1961 GQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG--SLVLKGLRASDAGAYTCVAHNPAGED- 2017
Query: 190 GKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSE 249
A+LH + PT++Q T++S + G VTM C
Sbjct: 2018 -------ARLHTVNVLVPPTIKQGA-------DGSGTLVS-------RPGELVTMVCPVR 2056
Query: 250 GLPAPEIFWSKK-----LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV 304
G P + W K L L H SG+ TL + +++ D+GI+ C + G +
Sbjct: 2057 GSPPIHVSWLKDGLPLPLSQRTLLHGSGH-TLRISKVQLADAGIFTCVAASPAGVADRNF 2115
Query: 305 ELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGT 364
L VQ P + + G V L C G P SW PL + +G
Sbjct: 2116 TLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKD-GEPLLSQSLEQG- 2173
Query: 365 NSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSG-----GLVNGS 419
+L L V + +Y C + + Q+ + P IE SG L G+
Sbjct: 2174 -PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVM---EPPHIEDSGQPTELSLTPGA 2229
Query: 420 SVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTD-MKSLENKSLEMTFIPTIEDTG 478
+ + C T NI + +D + LEN S T + + D G
Sbjct: 2230 PMELLCDAQG---------------TPQPNITWHKDGQALTRLENNS-RATRVLRVRDAG 2273
Query: 479 KALVCQAKLHIDDMEFEPKQR-QSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQ 537
C A+ +E + R Q+ + PR L +LE C +
Sbjct: 2274 -LYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLE--------CSVE 2324
Query: 538 GFPAPKILWSRQ----LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVE 593
PAPKI W R + Q L L + DSG Y C N AG +
Sbjct: 2325 AEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 2384
Query: 594 LIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSI---- 649
+ I P + P+ +V T ++ C VP + +K D
Sbjct: 2385 VEIHTVP--TIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILP 2442
Query: 650 DGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRE 689
+G+ I+ +DAG Y C + N GS D QGR+
Sbjct: 2443 EGSLRIQPVLAQDAGHYLCLASNSAGS-------DRQGRD 2475
Score = 89.0 bits (219), Expect = 1e-17
Identities = 107/426 (25%), Positives = 168/426 (39%), Gaps = 53/426 (12%)
Query: 283 MEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGD-SVMLTCSVMGCE 341
+ D GIY C NL G++++EV L V P I PGP A + + SV L C G
Sbjct: 575 LRDEGIYTCAATNLAGESKREVALKVLVPP---NIEPGPVNKAVLENASVTLECLASGVP 631
Query: 342 SPSFSW---RTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVT--CGHKKLEKGI 396
P SW + S + V +G L + + SY C + G +L G+
Sbjct: 632 PPDVSWFKGHQPVSSWMGVTVSVDGR--VLRIEQAQLSDAGSYRCVASNVAGSTELRYGL 689
Query: 397 QVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDT 456
+V + P + G ++ + V ++C T++ +L+D
Sbjct: 690 RVNVPPRITLPP-SLPGPVLVNTPVRLTCNATGA-----------PSPTLM----WLKDG 733
Query: 457 DMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFE-------PKQRQSTQTLYVNV 509
+ S F G+ L + D + + RQ L V++
Sbjct: 734 NPVSPAGTPGLQVF-----PGGRVLTLASARASDSGRYSCVAVSAVGEDRQDV-VLQVHM 787
Query: 510 APRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILW---SRQL-PNGELQPLSENATLT 565
P ++ S + E SV + C S P P + W R L P + ++ A L
Sbjct: 788 PPSILGEELNVSVVANE--SVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQ 845
Query: 566 LISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTC 625
+ + D+G Y CE +NQAG S K L + V P L + +V+EG +SC C
Sbjct: 846 VDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPV-FPLRESHTLTVREGHPTRLSCEC 904
Query: 626 GNVPETWIILKKKAE------TGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLR 679
VP I +K + G + ++ + +AQL G Y CE N VG+ +
Sbjct: 905 RGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQ 964
Query: 680 SLTLDV 685
L L+V
Sbjct: 965 DLQLEV 970
Score = 84.7 bits (208), Expect = 3e-16
Identities = 109/483 (22%), Positives = 181/483 (37%), Gaps = 59/483 (12%)
Query: 239 GGSVTMTCSSEGLPAPEIFWSKK----LDNG-NLQHLSGNATLTLIAMRMEDSGIYVCEG 293
G V + C + G+P P++ W+K L G +LQ L + + D G Y C
Sbjct: 141 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVA 200
Query: 294 VNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSW-RTQID 352
+ G+ ++ +L V P + +A V L C G +P+ +W +
Sbjct: 201 FSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGAL 260
Query: 353 SPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMS 412
P S KV L L + Y C + EK ++++Y P IE +
Sbjct: 261 LPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV---PPTIEGA 317
Query: 413 GG------LVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSL 466
GG V G V + C V +P L +G + E+ E +TD L +S
Sbjct: 318 GGRPYVVKAVAGRPVALEC-VARGHPSPTLSWHH-EGLPVAESNESRLETDGSVLRLES- 374
Query: 467 EMTFIPTIEDTGK-ALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILE 525
P +G + V + +++ + + Q L + TT++
Sbjct: 375 -----PGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIV-------- 421
Query: 526 EGSSVNMTCLSQGFPAPKILWSRQLPNGE-------LQPLSENATLTLISTKMEDSGVYL 578
G + + C + G P P I W L NG +Q S+ TL + +++ SG++
Sbjct: 422 -GQPLELPCQASGSPVPTIQW---LQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFA 477
Query: 579 CEGINQAGRSRKEVELII--QVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILK 636
C+ N+AG + EVE+ + + P +++ E + + V W
Sbjct: 478 CQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHP 537
Query: 637 KK--------------AETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLT 682
K TG V S+ I K L+D G+Y C + N G R +
Sbjct: 538 KPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVA 597
Query: 683 LDV 685
L V
Sbjct: 598 LKV 600
Score = 83.6 bits (205), Expect = 6e-16
Identities = 130/583 (22%), Positives = 214/583 (36%), Gaps = 80/583 (13%)
Query: 43 VSLTCSTTGCESPFFSWR---TQIDSPLNG-KVTNEGTTSTLTMNPVSFGNEHSYLCTAT 98
V LTC +TG +P SW Q+ + +G +V+ G P+ G Y C+A
Sbjct: 2592 VVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGR---YTCSAR 2648
Query: 99 CESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHL 158
+ K + + + + P + A + + + C + + R I K
Sbjct: 2649 NSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGI---PRPTITWQK---- 2701
Query: 159 MKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQ 218
+ + L L + ED G L C AK + A+ + +
Sbjct: 2702 -EGLNVATGVSTQVLPGGQLRIAHASP-EDAGNYL-CIAK---------NSAGSAMGKTR 2749
Query: 219 VYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATL-- 276
+ + + + P EG + C + G P P I W K D + G T+
Sbjct: 2750 LVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDK--DGQPVSGAEGKFTIQP 2807
Query: 277 --TLIAMRME--DSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVM 332
L+ +E D+G Y C N +G+ R+ V L + P + PG R + ++GD +
Sbjct: 2808 SGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTL-PGDR-SLRLGDRLW 2865
Query: 333 LTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLC--------- 383
L C+ G +P W T D P++ V + STL + VS E+ +Y+C
Sbjct: 2866 LRCAARGSPTPRIGW-TVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRT 2924
Query: 384 -TVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLK 442
V+ H K +Q E +S+ +E GG + V VP ++
Sbjct: 2925 QAVSFVHVKEAPVLQGEAFSY----LVEPVGGSIQLDCVVRGDPVPDIH----------- 2969
Query: 443 GETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQST 502
I + + L+N SL T T D C A E E +
Sbjct: 2970 --WIKDGLPLRGSHLRHQLQNGSL--TIRRTERDDAGRYQCLA-------ENEMGVAKKV 3018
Query: 503 QTLYVNVAPRDTTVLVSPSSI-LEEGSSVNMTCLSQGFPAPKILW---SRQLPNGELQPL 558
L + AP V P + + G V + C + G P P I W + L
Sbjct: 3019 VILVLQSAP---VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRT 3075
Query: 559 SENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPK 601
+ +L L + + D+G Y C N G + L+++ P+
Sbjct: 3076 LPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQ 3118
Score = 83.2 bits (204), Expect = 8e-16
Identities = 138/688 (20%), Positives = 257/688 (37%), Gaps = 75/688 (10%)
Query: 44 SLTCSTTGCESPFFSWRTQ---IDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCE 100
+L C+ TG P +W + + L ++ N+G +L + + Y C A
Sbjct: 995 TLECNATGKPPPTVTWERDGQPVGAELGLQLQNQG--QSLHVERAQAAHTGRYSCVAENL 1052
Query: 101 SRKLEKGIQVEIYSFPK-----DPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKG 155
+ + E+ ++ + P+ DP +++ L + P+T+ C + P
Sbjct: 1053 AGRAERKFELSVLVPPELIGDLDPLTNITAALHS--PLTLLCEAMGIPP---------PA 1101
Query: 156 DHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVK 215
+ +E + + L + T E + C A E +V
Sbjct: 1102 IRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSV----- 1156
Query: 216 ELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSK---KLDNGNLQHLSG 272
+V + P + K+ +G + + C+ G P P++ W K L G+ H+S
Sbjct: 1157 --EVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISP 1214
Query: 273 NAT-LTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTV---EISPGPRIAAQIG 328
+ L ++ + +G Y C N +G+ K +L V P + E S + +
Sbjct: 1215 DGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVN 1274
Query: 329 DSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHS--YLCTVT 386
+ + L C + SP+ +W +P + T L ++ + E + Y C VT
Sbjct: 1275 NPISLICEALAFPSPNITWMKD-GAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVT 1333
Query: 387 CGHKKLEKGIQVELYSFPR----DPEIEMSGGLVN---GSSVTVSCKVPSVYPLDRLEIE 439
+ K VE+ P DP E+ V S++T+ C+ +V P +
Sbjct: 1334 NELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYK 1393
Query: 440 LLKGETILENIEFLEDTDMKSLENKSLEMTFIPT-IEDTGKAL-VCQAKLHIDDMEFEPK 497
+ T ++ L + + ++ PT + D+G+ L V DD +F
Sbjct: 1394 DGQPVTPSSRLQVLGEGRLLQIQ---------PTQVSDSGRYLCVATNVAGEDDQDFNVL 1444
Query: 498 -------QRQSTQTLYVNVAPRDTTVL--VSPSSILEEGSSVNMTCLSQGFPAPKILWSR 548
Q+ + + R+ V+ + E + + C + P P + W R
Sbjct: 1445 IQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYR 1504
Query: 549 Q----LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIK 604
+ E+ L L + + E++G Y C+ N+ G EL++ P +
Sbjct: 1505 EDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILG 1564
Query: 605 LTAFPSESVKEGDTVIISCTC---GN-VPE-TWIILKKKAETGDTVLKSIDG-AYTIRKA 658
T E V + +S C GN VP +W+ + DG + A
Sbjct: 1565 DTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTA 1624
Query: 659 QLKDAGVYECESKNKVGSQLRSLTLDVQ 686
++ DA Y C ++N+ GS + TL VQ
Sbjct: 1625 EVADAASYMCVAENQAGSAEKLFTLRVQ 1652
Score = 82.4 bits (202), Expect = 1e-15
Identities = 143/686 (20%), Positives = 255/686 (37%), Gaps = 71/686 (10%)
Query: 28 ETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSF 87
E + + + + +SL C SP +W +P + T + ++
Sbjct: 1262 EDSADEEVTVTVNNPISLICEALAFPSPNITWMKD-GAPFEASRNIQLLPGTHGLQILNA 1320
Query: 88 GNEHS--YLCTATCESRKLEKGIQVEIY---SFPKDPEIHLSGPLEA----GKPITVKC- 137
E + Y C T E + K VE+ S KD + G E +T++C
Sbjct: 1321 QKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECE 1380
Query: 138 SVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRA 197
S A P R D G + S + + L+ + +V+ D G+ L
Sbjct: 1381 SWAVPPPTIRWYKD---GQPVTPSSRLQVLGEGRLLQIQPTQVS------DSGRYLCVAT 1431
Query: 198 KLH-IDEMD-----SVPTVRQAVKEL----QVYISPKNTVISVNPSTKLQEGGSVTMTCS 247
+ D+ D VP + Q V + ++ + V ++ E + C
Sbjct: 1432 NVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCD 1491
Query: 248 SEGLPAPEIFWSKK---LDNGN-LQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKE 303
+ +P P++ W ++ L G+ + L G L + +R E++G Y C+ N +G++
Sbjct: 1492 TNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLH 1551
Query: 304 VELIVQEKPFTVEISPG--PRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRS 361
EL+V P + + + +V L C +G P+ SW Q P S R
Sbjct: 1552 YELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISW-LQNGLPFSPSPRL 1610
Query: 362 E--GTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDP--EIEMSGGLVN 417
+ L +S + SY+C EK + + PR ++E ++N
Sbjct: 1611 QVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILN 1670
Query: 418 GSSVTVSCKVPSVYPLDRLEIELLKGETIL---ENIEFLEDTDMKSLENKSLEMTFIPTI 474
SSV++ C V+ E+ K L E + L T L L + + T
Sbjct: 1671 -SSVSLPC---DVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTC 1726
Query: 475 EDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTC 534
E A Q + + + P RQ+ + P+D ++ G ++C
Sbjct: 1727 EALNAAGRDQKLVQLSVL-VPPAFRQAPR------GPQDAV-------LVRVGDKAVLSC 1772
Query: 535 LSQGFPAPKILWSRQ----LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRK 590
+ P P + W + + Q L L + ++ D G+Y C+ N AG + +
Sbjct: 1773 ETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVR 1832
Query: 591 EVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWIILKKKAETGDT-VL 646
L +QV P + + S G ++++C VP TW+ + E+ +
Sbjct: 1833 TFTLTVQV-PPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGV 1891
Query: 647 KSIDGAYTIRKAQLKDAGVYECESKN 672
S G + + Q AG Y C ++N
Sbjct: 1892 VSRGGRLQLSRLQPAQAGTYTCVAEN 1917
Score = 78.2 bits (191), Expect = 3e-14
Identities = 113/497 (22%), Positives = 192/497 (38%), Gaps = 58/497 (11%)
Query: 217 LQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLD-----NGNLQHLS 271
L+V + P VN + + E SVT+ C + G+P P++ W K G +
Sbjct: 598 LKVLVPPNIEPGPVNKA--VLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVD 655
Query: 272 GNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKP-FTVEIS-PGPRIAAQIGD 329
G L + ++ D+G Y C N+ G L V P T+ S PGP + +
Sbjct: 656 GR-VLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVL---VNT 711
Query: 330 SVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGT--------NSTLTLSPVSFENEHSY 381
V LTC+ G SP+ W V GT LTL+ + Y
Sbjct: 712 PVRLTCNATGAPSPTLMWLKD-----GNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 766
Query: 382 LCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELL 441
C + + + ++++ P E++ +V SV + C+ ++ P
Sbjct: 767 SCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPP--------- 817
Query: 442 KGETILENIEFLEDTDMKSLENK-SLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQ 500
+L + D + LE + + ++ + +A V A + + + +
Sbjct: 818 ---PVLSWWK-----DGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSE 869
Query: 501 STQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQ---LP--NGEL 555
L V VAP + S + + EG ++C +G P PKI W + LP L
Sbjct: 870 KHYNLNVWVAP-VFPLRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGL 928
Query: 556 QPLSE-NATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSE-SV 613
Q +S L L ++ G Y CE N G S ++++L + V P+ P++ SV
Sbjct: 929 QHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSV 988
Query: 614 KEGDTVIISCTCGNVPETWIILKKK-----AETGDTVLKSIDGAYTIRKAQLKDAGVYEC 668
+ + C P + ++ AE G L++ + + +AQ G Y C
Sbjct: 989 VQDGVATLECNATGKPPPTVTWERDGQPVGAELG-LQLQNQGQSLHVERAQAAHTGRYSC 1047
Query: 669 ESKNKVGSQLRSLTLDV 685
++N G R L V
Sbjct: 1048 VAENLAGRAERKFELSV 1064
Score = 72.4 bits (176), Expect = 1e-12
Identities = 100/482 (20%), Positives = 177/482 (36%), Gaps = 50/482 (10%)
Query: 239 GGSVTMTCSSEGLPAPEIFWSKKLDN-------------------GNLQHLSGNATLTLI 279
G S+T+ C + G P PEI W K G + L +L
Sbjct: 33 GQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFP 92
Query: 280 AMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMG 339
++ DSG+Y C N G +++ L+V P + + G V L C G
Sbjct: 93 RIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSG 152
Query: 340 CESPSFSWRTQIDSPLSG----KVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKG 395
+P W L G +V+ +G +T S V +E Y C + +
Sbjct: 153 VPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVG--DEGRYQCVAFSPAGQQARD 210
Query: 396 IQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETI-LENIEFLE 454
Q+ +++ P + GS+ T V D L L + + NI + +
Sbjct: 211 FQLRVHAPP----------TIWGSNETGEVAVME----DHLVQLLCEARGVPTPNITWFK 256
Query: 455 DTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDT 514
D + K + ++ G+A A ++ + L V V P
Sbjct: 257 DGALLPTSTKVVYTRGGRQLQ-LGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIE 315
Query: 515 TVLVSPSSI-LEEGSSVNMTCLSQGFPAPKILWSRQ-LP---NGELQPLSENATLTLIST 569
P + G V + C+++G P+P + W + LP + E + ++ + L L S
Sbjct: 316 GAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESP 375
Query: 570 KMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVP 629
SG+Y C + AG + + + +QV P+ + + G + + C P
Sbjct: 376 GEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSP 435
Query: 630 E---TWIILKKKAETGDTVLKSIDG-AYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 685
W+ + AE V + G I +L +G++ C++ N+ G+ + + V
Sbjct: 436 VPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSV 495
Query: 686 QG 687
G
Sbjct: 496 HG 497
Score = 68.2 bits (165), Expect = 3e-11
Identities = 152/728 (20%), Positives = 260/728 (35%), Gaps = 95/728 (13%)
Query: 36 LAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNG----KVTNEGTTSTLTMNPVSFGNEH 91
L G V L C T+G +P W L G +V +G +T + V G+E
Sbjct: 137 LGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHV--GDEG 194
Query: 92 SYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEID 151
Y C A + + + Q+ +++ P + G E G+ ++ D L +
Sbjct: 195 RYQCVAFSPAGQQARDFQLRVHAPPT-----IWGSNETGEVAVME---------DHL-VQ 239
Query: 152 LLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIE--DIGKVLVCRAKLHIDEMDSVPT 209
LL + + D L T S +V +T +G+ A ++ + +
Sbjct: 240 LLCEARGVPTPNITWFKDGALLPT-STKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVG 298
Query: 210 VRQAVKELQVYISPKNTVISVNP-STKLQEGGSVTMTCSSEGLPAPEIFWSKK----LDN 264
+ L VY+ P P K G V + C + G P+P + W + ++
Sbjct: 299 AAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAES 358
Query: 265 GNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIA 324
+ + + L L + SG+Y C + G+ + + VQ P + ++
Sbjct: 359 NESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVT 418
Query: 325 AQIGDSVMLTCSVMGCESPSFSW--RTQIDSPLSG-KVRSEGTNSTLTLSPVSFENEHSY 381
+G + L C G P+ W + L+G +V S+GT TL + V ++ +
Sbjct: 419 TIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGT--TLHIDHVELDHSGLF 476
Query: 382 LCTVT--CGHKKLEKGIQVELYSFPRDPEI---EMSGGLVNGSSVTVSCKVP-----SVY 431
C T G E + V P E+ + G + SS +C P +
Sbjct: 477 ACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAH 536
Query: 432 PLDRL-----EIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAK 486
P L L GE + + ++ +E L I T T L ++K
Sbjct: 537 PKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQ-IEKVDLRDEGIYTCAATN--LAGESK 593
Query: 487 LHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILW 546
+ P + P + VL + S LE CL+ G P P + W
Sbjct: 594 REVALKVLVPPN--------IEPGPVNKAVLENASVTLE--------CLASGVPPPDVSW 637
Query: 547 SRQLPNGELQPLS---------ENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQ 597
+ QP+S + L + ++ D+G Y C N AG + L +
Sbjct: 638 FK-----GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVN 692
Query: 598 VTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKK----AETGDTVLKSIDG-- 651
V P+ + P V V ++C P ++ K + G L+ G
Sbjct: 693 VPPRITLPPSLPG-PVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGR 751
Query: 652 AYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ------GRENNKDYFSPELLVLYFA 705
T+ A+ D+G Y C + + VG + + L V G E N + E + L
Sbjct: 752 VLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQ 811
Query: 706 SSLIIPAI 713
S + P +
Sbjct: 812 SHAMPPPV 819
Score = 52.8 bits (125), Expect = 1e-06
Identities = 53/209 (25%), Positives = 80/209 (38%), Gaps = 34/209 (16%)
Query: 511 PRDTTVLVSPSSILEEGSSVNMT----------CLSQGFPAPKILWSR--QLPN------ 552
P T V P SI E+G N++ C + GFP P+I+W + QL
Sbjct: 7 PLLNTGSVVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWA 66
Query: 553 -----------GELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPK 601
G + L E +L + DSG+Y C NQAG ++++ L++ P
Sbjct: 67 GYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPS 126
Query: 602 DIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAET----GDTVLKSIDG-AYTIR 656
+ A G V + C VP + K + G + DG I
Sbjct: 127 VLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRIT 186
Query: 657 KAQLKDAGVYECESKNKVGSQLRSLTLDV 685
+ + D G Y+C + + G Q R L V
Sbjct: 187 GSHVGDEGRYQCVAFSPAGQQARDFQLRV 215
Score = 50.8 bits (120), Expect = 4e-06
Identities = 75/305 (24%), Positives = 120/305 (39%), Gaps = 59/305 (19%)
Query: 29 TTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFG 88
T P R L ++GD + L C+ G +P W T D P+ V+ + STL VS
Sbjct: 2851 TLPGDRSL-RLGDRLWLRCAARGSPTPRIGW-TVNDRPVTEGVSEQDGGSTLQRAAVSRE 2908
Query: 89 NEHSYLCTATCESR------------KLEKGIQVEIYSFPKDPEIHLSGPLEA-----GK 131
+ +Y+C A E+R K +Q E +S+ +P + G ++ G
Sbjct: 2909 DSGTYVCWA--ENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEP---VGGSIQLDCVVRGD 2963
Query: 132 PITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGK 191
P+ + D P L+G HL R L+ SL + T +D G+
Sbjct: 2964 PVPDIHWIKDGLP--------LRGSHL-----------RHQLQNGSLTIRRTER-DDAGR 3003
Query: 192 VLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTK-LQEGGSVTMTCSSEG 250
C A+ +EM K++ + + V V P ++ G V + C + G
Sbjct: 3004 YQ-CLAE---NEMG-------VAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATG 3052
Query: 251 LPAPEIFW---SKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELI 307
P P I W + L + +L L + D+G Y C NL+G L+
Sbjct: 3053 EPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLV 3112
Query: 308 VQEKP 312
V+ +P
Sbjct: 3113 VRGEP 3117
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 102 bits (254), Expect = 1e-21
Identities = 155/697 (22%), Positives = 266/697 (38%), Gaps = 94/697 (13%)
Query: 37 AQIGDSVSLTCSTTGCESPFFSWR---TQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSY 93
A +GDSVSL C G SW T++ + +TL N V+ + Y
Sbjct: 6090 AAVGDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEY 6149
Query: 94 LCTA-----TCESRKL----EKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYP 144
C A T S+ + E+ + KD E G P+T+ C + P
Sbjct: 6150 TCKAENSIGTASSKTVFRIQERQLPPSFARQLKDIE------QTVGLPVTLTCRLNGSAP 6203
Query: 145 FDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEM 204
+++ + L++ E L+ + ++ T + T + G+ C A +
Sbjct: 6204 ---IQVCWYRDGVLLRDDENLQTSFVDNVATLKILQTD---LSHSGQYS-CSASNPLGTA 6256
Query: 205 DSVPTVRQAVKELQVYISPKNTVISVNP-STKLQEGGSVTMTCSSEGLPAPEIFWSKKLD 263
S + R +E + K+ + P S + G S C G I WSK D
Sbjct: 6257 SS--SARLTAREPK-----KSPFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSK--D 6307
Query: 264 NGNLQHLSGNATLT---------LIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFT 314
N ++ GN T+T ++ + DSG Y C+ N +GK+ +L V+E P
Sbjct: 6308 NKEIRP-GGNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKF 6366
Query: 315 VEISPGPRIAAQIGDSVMLTCSVMGCESPSFSW-RTQIDSPLSGKVRSEGTNST--LTLS 371
V+ ++A Q G+S+ L C + G SW R + S K NS LT++
Sbjct: 6367 VKKLEASKVAKQ-GESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFINSVALLTIN 6425
Query: 372 PVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVY 431
S E+ Y+C G + + + P + G + GS V + C++
Sbjct: 6426 EASAEDSGDYICEAHNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEISGTP 6485
Query: 432 PLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDD 491
P + + ++ D K + N S + DT ++ + +
Sbjct: 6486 PFEVVWVK-----------------DRKQVRN-SKKFKITSKHFDTSLHILNLEASDVGE 6527
Query: 492 MEFEPKQRQSTQTLYVNV----APRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWS 547
+ + T +V PR L S+++ G +V + + +GF ++W
Sbjct: 6528 YHCKATNEVGSDTCSCSVKFKEPPRFVKKLSDTSTLI--GDAVELRAIVEGFQPISVVWL 6585
Query: 548 RQLPNGELQPLSEN---------ATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQV 598
+ GE+ SEN ATL L S + +SG Y+C+ N AG +E ++ V
Sbjct: 6586 KD--RGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAG--MRECSAVLTV 6641
Query: 599 TPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWI----ILKKKAETGDTVLKSIDG 651
+ +V G+ + C PE W L ++ T + +
Sbjct: 6642 LEPARIIEKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFINKV-A 6700
Query: 652 AYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGR 688
+ I A++ D G+Y E KN VG ++++ V R
Sbjct: 6701 SLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDR 6737
Score = 97.8 bits (242), Expect = 3e-20
Identities = 160/700 (22%), Positives = 281/700 (40%), Gaps = 109/700 (15%)
Query: 39 IGDSVSLTCSTTGCESPFFSW---RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLC 95
+G S L C G +W +T+I S + T TL +N + + +Y C
Sbjct: 5813 LGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTC 5872
Query: 96 TATCESRKLEKGIQVEIY---SFPKDPEIHLSGPLEA--GKPITVKCSVADVYPFD---- 146
A + E + + SF K+PE PLE GK +T + PF
Sbjct: 5873 VAANVAGSDECRAVLTVQEPPSFVKEPE-----PLEVLPGKNVTFTSVIRGTPPFKVNWF 5927
Query: 147 RLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVT----FTPVIEDIGKVLVCRAKLHID 202
R +L+KGD + + ED + LE +++++ +T V+ + C +L +
Sbjct: 5928 RGARELVKGD---RCNIYFEDTVAE-LELFNIDISQSGEYTCVVSNNAGQASCTTRLFVK 5983
Query: 203 EMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK- 261
E + +K L + SV P G S+ + + G + W K
Sbjct: 5984 EPAAF------LKRLSDH--------SVEP------GKSIILESTYTGTLPISVTWKKDG 6023
Query: 262 -----LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKP-FTV 315
+ N+ L ++ D+G Y CE N G++ + E P F
Sbjct: 6024 FNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAGRDVCGALVSTLEPPYFVT 6083
Query: 316 EISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPL--SGKVRSEGTNS--TLTLS 371
E+ P + A +GDSV L C V G + SW D+ L + + R+ TN+ TL +
Sbjct: 6084 ELEP---LEAAVGDSVSLQCQVAGTPEITVSWYKG-DTKLRPTPEYRTYFTNNVATLVFN 6139
Query: 372 PVSFENEHSYLCTV-----TCGHKKLEKGIQVELY-SFPRD-PEIEMSGGLVNGSSVTVS 424
V+ + Y C T K + + + +L SF R +IE + GL VT++
Sbjct: 6140 KVNINDSGEYTCKAENSIGTASSKTVFRIQERQLPPSFARQLKDIEQTVGL----PVTLT 6195
Query: 425 CKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQ 484
C++ P+ ++ + +L + E L+ + + ++ + T + +G+ C
Sbjct: 6196 CRLNGSAPI---QVCWYRDGVLLRDDENLQTSFVDNVATLKILQT---DLSHSGQ-YSCS 6248
Query: 485 AKLHIDDMEFEPK--QRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAP 542
A + + R+ ++ + ++ P V+ G S + C G
Sbjct: 6249 ASNPLGTASSSARLTAREPKKSPFFDIKPVSIDVIA--------GESADFECHVTGAQPM 6300
Query: 543 KILWSRQLPNGELQPLSENATLTLISTKME---------DSGVYLCEGINQAGRSRKEVE 593
+I WS+ N E++P N T+T + DSG Y C+ N G+ +
Sbjct: 6301 RITWSKD--NKEIRP-GGNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQ 6357
Query: 594 LIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWI----ILKKKAETGDTVL 646
L ++ PK +K S+ K+G+++ + C PE +W L + + + +
Sbjct: 6358 LSVKEPPKFVKKLE-ASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFI 6416
Query: 647 KSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 686
S+ TI +A +D+G Y CE+ N VG S L V+
Sbjct: 6417 NSV-ALLTINEASAEDSGDYICEAHNGVGDASCSTALTVK 6455
Score = 90.9 bits (224), Expect = 4e-18
Identities = 144/683 (21%), Positives = 256/683 (37%), Gaps = 90/683 (13%)
Query: 40 GDSVSLTCSTTGCESPFFSW---RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCT 96
G SV + C G SW +I S + T T LT+N + + Y C
Sbjct: 7696 GSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCI 7755
Query: 97 ATCESRKLEKGIQVEIY---SFPKDPEIHLSGPLE--AGKPITVKCSVADVYPFD----R 147
AT + E + + SF + P+ P++ G +T V PF +
Sbjct: 7756 ATNMAGSDECSAPLTVREPPSFVQKPD-----PMDVLTGTNVTFTSIVKGTPPFSVSWFK 7810
Query: 148 LEIDLLKGDHLMKS-QEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDS 206
+L+ GD S ++ + + + ++T S +T ++ + C L+I
Sbjct: 7811 GSSELVPGDRCNVSLEDSVAELELFDVDT-SQSGEYTCIVSNEAGKASCTTHLYI----- 7864
Query: 207 VPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDN-- 264
+ VK L Y +++G + + + G P + W K N
Sbjct: 7865 -KAPAKFVKRLNDY--------------SIEKGKPLILEGTFTGTPPISVTWKKNGINVT 7909
Query: 265 ----GNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTV-EISP 319
N+ +A L + + +ED+G Y C N GK+ ++++ E P+ V ++ P
Sbjct: 7910 PSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQLEP 7969
Query: 320 GPRIAAQIGDSVMLTCSVMGCESPSFSW---RTQIDSPLSGKVRSEGTNSTLTLSPVSFE 376
+ +GDS L C + G SW T++ + K+ +TL + V
Sbjct: 7970 ---VKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDIN 8026
Query: 377 NEHSYLCTV--TCGHKKLEKGIQVELYSFPRDPEIEMSGGLVN-GSSVTVSCKVPSVYPL 433
+ Y+C + G + V+ P ++ G V C + P+
Sbjct: 8027 DSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPI 8086
Query: 434 DRLEIELLKGETILENIE--FLEDTDMKSL--ENKSLEMTFIPTIEDTGKALVCQAKLHI 489
+ K N++ FL++T ++ ++SL + T + + A+L +
Sbjct: 8087 SVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLIL 8146
Query: 490 DDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILW--- 546
+ + P + +AP D V G S + C G K+ W
Sbjct: 8147 TEGKNPP-------FFDIRLAPVDAVV----------GESADFECHVTGTQPIKVSWAKD 8189
Query: 547 SRQLPNG---ELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQ---VTP 600
SR++ +G ++ L +A LT++ DSG Y C +N+ G+ +L I+ + P
Sbjct: 8190 SREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPP 8249
Query: 601 KDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDT-----VLKSIDGAYTI 655
K + E + + G+ P T K E T K+ +
Sbjct: 8250 SFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNTLVLQV 8309
Query: 656 RKAQLKDAGVYECESKNKVGSQL 678
RKA + DAG+Y C+ N GS L
Sbjct: 8310 RKAGMNDAGLYTCKVSNDAGSAL 8332
Score = 86.7 bits (213), Expect = 7e-17
Identities = 117/501 (23%), Positives = 206/501 (41%), Gaps = 70/501 (13%)
Query: 223 PKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW---SKKLDNGN---LQHLSGNATL 276
P + V V+PS + G S + C +G P ++ W +K+L N + ++ A L
Sbjct: 3736 PPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAIL 3795
Query: 277 TLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKP-FTVEISPGPRIAAQIGDSVMLTC 335
+ +++EDSG Y CE VN +G + E++++E P F + P + G + +L C
Sbjct: 3796 DITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPPSFIKTLEPADIVR---GTNALLQC 3852
Query: 336 SVMGCESPSFSW---RTQIDSPLSGKVRSEGTNSTLTLSPVSFENEH--SYLCTVT---- 386
V G SW + QI S S K R S + L SF + Y C V
Sbjct: 3853 EVSGTGPFEISWFKDKKQIRS--SKKYRLFSQKSLVCLEIFSFNSADVGEYECVVANEVG 3910
Query: 387 -CGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGET 445
CG + + E +F + + ++ G G +VT+ V P + + +KG+
Sbjct: 3911 KCG--CMATHLLKEPPTFVKKVDDLIALG---GQTVTLQAAVRGSEP---ISVTWMKGQE 3962
Query: 446 ILENIEFLEDTDMKSLENKSLEMTFIPTIE-DTGKALVCQAKLHIDDMEFEPKQRQSTQT 504
++ ED +K + + + IP ++ G C A + +QT
Sbjct: 3963 VIR-----EDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLA-----------ENEAGSQT 4006
Query: 505 LYVNVAPRDTTVLVSPSSILE--EGSSVNMTCLSQGFPAPKILW---SRQLPNGELQPLS 559
+ ++ ++ + +++ G + G P K W R L + +S
Sbjct: 4007 SVGELIVKEPAKIIERAELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYRIS 4066
Query: 560 ---ENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEG 616
A L S ++ DSG Y E N+ G S E T D + F ++ ++
Sbjct: 4067 FKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTF----TVLDRDIAPFFTKPLRNV 4122
Query: 617 DTVI-----ISC-TCGNVP--ETWIILKKKAETGDTV-LKSIDGAYTIR--KAQLKDAGV 665
D+V+ + C G++P +W K+ D + ++G ++ + + DAG
Sbjct: 4123 DSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGN 4182
Query: 666 YECESKNKVGSQLRSLTLDVQ 686
+ C + N VGS+ S L VQ
Sbjct: 4183 FTCRATNSVGSKDSSGALIVQ 4203
Score = 80.1 bits (196), Expect = 7e-15
Identities = 116/493 (23%), Positives = 192/493 (38%), Gaps = 60/493 (12%)
Query: 226 TVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW---SKKLDNGNLQHLS---GNATLTLI 279
T++ S K+ G + T+ C+ G P W K+L + N +S + L +I
Sbjct: 7587 TIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSGLKII 7646
Query: 280 AMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKP----FTVEISPGPRIAAQIGDSVMLTC 335
+ DSG+Y E N +GK+ L V ++ FT ++ ++ G SV++ C
Sbjct: 7647 NVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLS---GSSVVMEC 7703
Query: 336 SVMGCESPSFSWRTQIDSPLSG-KVRSEGTNSTLTLSPVSFENEHS--YLCTVT--CGHK 390
V G S SW + + SG K ++ T++T L+ E S Y C T G
Sbjct: 7704 KVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSD 7763
Query: 391 KLEKGIQV-ELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILEN 449
+ + V E SF + P+ ++ G++VT + V P + KG + L
Sbjct: 7764 ECSAPLTVREPPSFVQKPD---PMDVLTGTNVTFTSIVKGTPPFS---VSWFKGSSELVP 7817
Query: 450 IEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNV 509
D SLE+ E+ C + E + T LY+
Sbjct: 7818 ----GDRCNVSLEDSVAELELFDVDTSQSGEYTCI-------VSNEAGKASCTTHLYIK- 7865
Query: 510 APRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNG------ELQPLSENAT 563
AP ++ SI E+G + + G P + W + N + ++A
Sbjct: 7866 APAKFVKRLNDYSI-EKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAI 7924
Query: 564 LTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISC 623
L + S+ +ED+G Y C N +G+ +++I P +K V GD+ + C
Sbjct: 7925 LEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVK--QLEPVKVSVGDSASLQC 7982
Query: 624 TCGNVPETWIILKKKAETGDTVLKSID----------GAYTIRKAQLKDAGVYECESKNK 673
PE + K GDT L+ + + D+G Y C+++N
Sbjct: 7983 QLAGTPEIGVSWYK----GDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENS 8038
Query: 674 VGSQLRSLTLDVQ 686
VG S L VQ
Sbjct: 8039 VGEVSASTFLTVQ 8051
Score = 79.0 bits (193), Expect = 2e-14
Identities = 112/480 (23%), Positives = 187/480 (38%), Gaps = 64/480 (13%)
Query: 240 GSVTMTCSSEGLPAPEIFWSKK------LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEG 293
G+ + C G + W K D + + G A+L +I + M D+G + C
Sbjct: 4128 GTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFTCRA 4187
Query: 294 VNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSW---RTQ 350
N +G LIVQE P V PG + G +V L + G + W +
Sbjct: 4188 TNSVGSKDSSGALIVQEPPSFV-TKPGSKDVLP-GSAVCLKSTFQGSTPLTIRWFKGNKE 4245
Query: 351 IDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDP--- 407
+ S S + E S+L L V + +Y C V+ + G++ F ++P
Sbjct: 4246 LVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVS----NVAGGVECSANLFVKEPATF 4301
Query: 408 --EIEMSGGLVNGSSVTVSCKVPSVYPL-------DRLEIELLKGETILENIEFLEDTDM 458
++E S L G + ++CKV P+ DR EI+ E+ + F+E T +
Sbjct: 4302 VEKLEPSQLLKKGDATQLACKVTGTPPIKITWFANDR-EIK----ESSKHRMSFVESTAV 4356
Query: 459 KSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLV 518
L + IED+G+ +C+A + E + + V +P T
Sbjct: 4357 LRLTDVG--------IEDSGE-YMCEA-------QNEAGSDHCSSIVIVKESPYFTKEF- 4399
Query: 519 SPSSILEEGSSVNMTCLSQGFPAPKILWSRQ---LPNGELQPL---SENATLTLISTKME 572
P +L+E V + G P +I W + L +G +L ++
Sbjct: 4400 KPIEVLKE-YDVMLLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAA 4458
Query: 573 DSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTC-GNVP-- 629
D+G Y C N+ G S + ++ P IK S S G T T G++P
Sbjct: 4459 DAGEYQCRVTNEVGSSICSARVTLREPPSFIK--KIESTSSLRGGTAAFQATLKGSLPIT 4516
Query: 630 ETWIILKKKAETGDTVLKSID---GAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 686
TW+ + D + + + + + ++K G Y C++KN G Q S L V+
Sbjct: 4517 VTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVK 4576
Score = 79.0 bits (193), Expect = 2e-14
Identities = 111/490 (22%), Positives = 196/490 (40%), Gaps = 47/490 (9%)
Query: 223 PKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDN------GNLQHLSGNATL 276
P V + S ++G S+ + C G P ++ W + N+ ++ A L
Sbjct: 6363 PPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFINSVALL 6422
Query: 277 TLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKP-FTVEISPGPRIAAQIGDSVMLTC 335
T+ EDSG Y+CE N +G L V+ P FT + SP + A G V+L C
Sbjct: 6423 TINEASAEDSGDYICEAHNGVGDASCSTALTVKAPPVFTQKPSP---VGALKGSDVILQC 6479
Query: 336 SVMGCESPSFSW---RTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKL 392
+ G W R Q+ + K+ S+ +++L + + + Y C T
Sbjct: 6480 EISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSD 6539
Query: 393 EKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEF 452
V+ PR + + G +V + V P+ + ++ +GE I E+
Sbjct: 6540 TCSCSVKFKEPPRFVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKD-RGEVIRES--- 6595
Query: 453 LEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPR 512
E+T + ++N + P ++GK +CQ K + R+ + L V R
Sbjct: 6596 -ENTRISFIDNIATLQLGSPEASNSGK-YICQIKN-------DAGMRECSAVLTVLEPAR 6646
Query: 513 DTTVLVSPSSI-LEEGSSVNMTCLSQGFPAPKILW---SRQLP---NGELQPLSENATLT 565
++ P + + G+ + C+ G P W R+L + +++ A+L
Sbjct: 6647 ---IIEKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFINKVASLK 6703
Query: 566 LISTKMEDSGVYLCEGINQAGRSRKEVELIIQ---VTPKDIKLTAFPSESVKEGDTVIIS 622
+ +M D G+Y E N G+S V + + V P I+ + G +V++
Sbjct: 6704 IPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFIR--KLKDVNAILGASVVLE 6761
Query: 623 C-TCGNVPET--WIILKKKAETGDTVLKSI-DGAYTIRKAQLK--DAGVYECESKNKVGS 676
C G+ P + W + +G S + T+ + L+ D G+Y C + N GS
Sbjct: 6762 CRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGS 6821
Query: 677 QLRSLTLDVQ 686
S L VQ
Sbjct: 6822 DECSAVLTVQ 6831
Score = 78.6 bits (192), Expect = 2e-14
Identities = 106/499 (21%), Positives = 190/499 (38%), Gaps = 54/499 (10%)
Query: 219 VYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSK------KLDNGNLQHLSG 272
+++ T + ++ G + + + G P + W K + + ++
Sbjct: 6921 LFVKEPATFVKRLADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEK 6980
Query: 273 NATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVM 332
+ L ++ +ED Y C N G++ E + V E P+ +E P + A IG+
Sbjct: 6981 STILEILESTIEDYAQYSCLIENEAGQDICEALVSVLEPPYFIE--PLEHVEAVIGEPAT 7038
Query: 333 LTCSVMGCESPSFSW---RTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGH 389
L C V G SW T++ S + K++ + ++L ++ V + Y C
Sbjct: 7039 LQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSV 7098
Query: 390 KKLEKGIQVELYSFPRDPEIEMSGGLVN---GSSVTVSCKVPSVYPLDRLEIELLKGETI 446
+ + + + P V+ G V C++ PL ++ K +
Sbjct: 7099 GAVASSAVLVIKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPL---QVSWYKDGVL 7155
Query: 447 LENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLY 506
L+ ++ +L+ +F+ + Q+ HI T +
Sbjct: 7156 LK-------------DDANLQTSFVHNVATLQILQTDQS--HIGQYNCSASNPLGTASSS 7200
Query: 507 VNVAPRDTTVL----VSPSSI-LEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQP---- 557
+ + V + P S+ L G S C G KI W++ N E++P
Sbjct: 7201 AKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAKD--NREIRPGGNY 7258
Query: 558 ---LSEN-ATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESV 613
L EN ATLT++ D+G Y C N AG+ +L +Q P+ IK PS V
Sbjct: 7259 KMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLE-PSRIV 7317
Query: 614 KEGDTVIISCTCGNVPETWIILKKK----AETGDTVLKSIDGAYTIRKAQL--KDAGVYE 667
K+ + C G PE ++ K E+ + +D + L +D+G Y
Sbjct: 7318 KQDEFTRYECKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYT 7377
Query: 668 CESKNKVGSQLRSLTLDVQ 686
CE+ N GS S +L V+
Sbjct: 7378 CEAHNAAGSASSSTSLKVK 7396
Score = 77.4 bits (189), Expect = 4e-14
Identities = 146/689 (21%), Positives = 271/689 (39%), Gaps = 92/689 (13%)
Query: 43 VSLTCSTTGC---ESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATC 99
VSL C +G E ++ + Q+ S K+ ++ +++ + V + Y C A
Sbjct: 5534 VSLECELSGTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQN 5593
Query: 100 ESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLM 159
E V++ P+ S + AG+P ++ S+ P
Sbjct: 5594 EVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPI-------------- 5639
Query: 160 KSQEFLEDADRKSLETKSLEVTFTPVIEDI--GKVLVCRAKLHIDEMDSVPTVRQAVKEL 217
++L++ + E++++ +TF + + K A +I ++ + +R+ + L
Sbjct: 5640 -FVQWLKEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENMATL 5698
Query: 218 QVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSK--KLDNGNLQH----LS 271
V + P V P T + G + T+ C G P + W K KL + +H +
Sbjct: 5699 MV-LEPAVIVEKAGPMT-VTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYN 5756
Query: 272 GNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKP----FTVEISPGPRIAAQI 327
++L ++++ +D+G Y + N +GK+ + V ++ FT + +
Sbjct: 5757 KISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLK---NTGGVL 5813
Query: 328 GDSVMLTCSVMGCESPSFSW---RTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCT 384
G S +L C V G S +W +T+I S + TL L+ + + +Y C
Sbjct: 5814 GASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCV 5873
Query: 385 VT--CGHKKLEKGIQV-ELYSFPRDPE-IEMSGGLVNGSSVTVSCKVPSVYPLD----RL 436
G + + V E SF ++PE +E+ + G +VT + + P R
Sbjct: 5874 AANVAGSDECRAVLTVQEPPSFVKEPEPLEV----LPGKNVTFTSVIRGTPPFKVNWFRG 5929
Query: 437 EIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEP 496
EL+KG+ NI F EDT + LE +++++ Q+ + +
Sbjct: 5930 ARELVKGDRC--NIYF-EDT-VAELELFNIDIS--------------QSGEYTCVVSNNA 5971
Query: 497 KQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPN---- 552
Q T L+V P +S S+ E G S+ + G + W + N
Sbjct: 5972 GQASCTTRLFVK-EPAAFLKRLSDHSV-EPGKSIILESTYTGTLPISVTWKKDGFNITTS 6029
Query: 553 --GELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPS 610
+ + L ++++ D+G Y CE N+AGR L+ + P P
Sbjct: 6030 EKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAGRDVCGA-LVSTLEPPYFVTELEPL 6088
Query: 611 ESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYT----------IRKAQL 660
E+ GD+V + C PE + K GDT L+ T K +
Sbjct: 6089 EAAV-GDSVSLQCQVAGTPEITVSWYK----GDTKLRPTPEYRTYFTNNVATLVFNKVNI 6143
Query: 661 KDAGVYECESKNKVGSQLRSLTLDVQGRE 689
D+G Y C+++N +G+ +Q R+
Sbjct: 6144 NDSGEYTCKAENSIGTASSKTVFRIQERQ 6172
Score = 76.3 bits (186), Expect = 1e-13
Identities = 127/560 (22%), Positives = 217/560 (38%), Gaps = 85/560 (15%)
Query: 151 DLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTV 210
+L+ G ++E LE + L S T+T + ++ + C A L + E
Sbjct: 4245 ELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKE------- 4297
Query: 211 RQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW------SKKLDN 264
P V + PS L++G + + C G P +I W K+
Sbjct: 4298 ------------PATFVEKLEPSQLLKKGDATQLACKVTGTPPIKITWFANDREIKESSK 4345
Query: 265 GNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKP-FTVEISPGPRI 323
+ + A L L + +EDSG Y+CE N G + +IV+E P FT E P I
Sbjct: 4346 HRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKEFKP---I 4402
Query: 324 AAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSG-KVRSEGTNSTLTLSPVSF--ENEHS 380
VML V G +W SG K ++ + ++L + F +
Sbjct: 4403 EVLKEYDVMLLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGE 4462
Query: 381 YLCTVTCGHKKLEKGIQVELYSFPR-DPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIE 439
Y C VT +V L P +IE + L G++ +
Sbjct: 4463 YQCRVTNEVGSSICSARVTLREPPSFIKKIESTSSLRGGTAAFQA--------------- 4507
Query: 440 LLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQR 499
LKG + + +L+D+D + E+ ++ MTF + A L++ +E + +
Sbjct: 4508 TLKGSLPI-TVTWLKDSD-EITEDDNIRMTFENNV----------ASLYLSGIEVKHDGK 4555
Query: 500 QSTQTLYVNVAPRDTTVL--VSPSSILEEGSSVNMT-----CLSQGFPAPKILWSRQLPN 552
Q R + +L P++I EE S+++T L F K + ++ +
Sbjct: 4556 YVCQAKNDAGIQRCSALLSVKEPATITEEAVSIDVTQGDPATLQVKFSGTKEITAKWFKD 4615
Query: 553 GELQPLSEN---------ATLTLISTKMEDSGVYLCEGINQAGRS--RKEVELIIQVTPK 601
G+ L + L +IST+ +DSG Y E N GRS + + ++ + P
Sbjct: 4616 GQELTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPP 4675
Query: 602 DIKLTAFPSESVKEGDTVIISC-TCGNVPET--WIILKKKAETGDTVLKSI-DGAYTIRK 657
+S+K G + + C G+ P + W ++ + S D +
Sbjct: 4676 SFTKKLKKMDSIK-GSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFSFHDNTAFLEI 4734
Query: 658 AQLK--DAGVYECESKNKVG 675
+QL+ D+G Y C + NK G
Sbjct: 4735 SQLEGTDSGTYTCSATNKAG 4754
Score = 76.3 bits (186), Expect = 1e-13
Identities = 159/698 (22%), Positives = 257/698 (36%), Gaps = 121/698 (17%)
Query: 40 GDSVSLTCSTTGCESPFFSWRTQIDSPLNG---KVTNEGTTSTLTMNPVSFGNEHSYLCT 96
G +V+ T G SW + G V+ E + + L + V Y C
Sbjct: 7789 GTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCI 7848
Query: 97 ATCESRKLEKGIQVEI------------YSFPKDPEIHLSGPLEAGKPITV--KCSVADV 142
+ E+ K + I YS K + L G PI+V K + +V
Sbjct: 7849 VSNEAGKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINV 7908
Query: 143 YPFDRLEIDLLKGDHLMK-SQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHI 201
P R I + +++ +EDA + + IE+ C A++ I
Sbjct: 7909 TPSQRCNITTTEKSAILEIPSSTVEDAGQ-----------YNCYIENASGKDSCSAQILI 7957
Query: 202 DEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSK- 260
+ P V + P K+ G S ++ C G P + W K
Sbjct: 7958 -------------------LEPPYFVKQLEP-VKVSVGDSASLQCQLAGTPEIGVSWYKG 7997
Query: 261 ----KLDNGNLQHLSGN-ATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTV 315
+ H N ATL + + DSG Y+C+ N +G+ L VQE+
Sbjct: 7998 DTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPP 8057
Query: 316 EISPGPR-IAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPL--SGKVRSEGTNSTLTLSP 372
S R + +G V+ C++ G E S SW PL S V++ ++T TL+
Sbjct: 8058 SFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKD-GKPLKDSPNVQTSFLDNTATLN- 8115
Query: 373 VSFENEHS----YLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVN---GSSVTVSC 425
F+ + S Y CT T ++ L P ++ V+ G S C
Sbjct: 8116 -IFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFEC 8174
Query: 426 KVPSVYPLDRLEIELLKGETILEN-----IEFLED----TDMKSLENKSLEMTFIPTIED 476
V P +++ K + + I +LE+ T +K + S + T + +
Sbjct: 8175 HVTGTQP---IKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCY-AVNE 8230
Query: 477 TGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLS 536
GK C A+L+I + + P T +S + EG+S +
Sbjct: 8231 VGKD-SCTAQLNIKE----------------RLIPPSFTKRLSETVEETEGNSFKLEGRV 8273
Query: 537 QGFPAPKILWSRQLPNGELQPLS------ENATLTLISTK--MEDSGVYLCEGINQAGRS 588
G + W + N E+QP S +N TL L K M D+G+Y C+ N AG +
Sbjct: 8274 AGSQPITVAWYKN--NIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSA 8331
Query: 589 RKEVELIIQVTPK----DIKLTAFPSESVKEGDTVIISC-TCGNVP--ETWIILKKKAET 641
++I+ K D LT +V EG+ V +SC G+ P W+ ++ +
Sbjct: 8332 LCTSSIVIKEPKKPPVFDQHLTPV---TVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKP 8388
Query: 642 GDTV---LKSIDGAYTIRKAQLKDAGVYECESKNKVGS 676
D S +R D+G Y C++ N GS
Sbjct: 8389 SDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGS 8426
Score = 75.9 bits (185), Expect = 1e-13
Identities = 153/715 (21%), Positives = 251/715 (35%), Gaps = 130/715 (18%)
Query: 37 AQIGDSVSLTCSTTGCESPFFSW---RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSY 93
A IG+ +L C G SW T++ S K+ + ++L +N V + Y
Sbjct: 7031 AVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEY 7090
Query: 94 LCTATCESRKLEKGIQVEIYSFPKDP-------EIHLSGPLEAGKPITVKCSVADVYPFD 146
C A + + I + P ++H + G P+ +C + P
Sbjct: 7091 SCKADNSVGAVASSAVLVIKARKLPPFFARKLKDVHET----LGFPVAFECRINGSEP-- 7144
Query: 147 RLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDS 206
L++ K L+K L+ + ++ T + T I C A + S
Sbjct: 7145 -LQVSWYKDGVLLKDDANLQTSFVHNVATLQILQTDQSHIGQYN----CSASNPLGTASS 7199
Query: 207 VPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKL---- 262
+ + E+ + K S L G S T C G +I W+K
Sbjct: 7200 SAKLILSEHEVPPFFDLKPV------SVDLALGESGTFKCHVTGTAPIKITWAKDNREIR 7253
Query: 263 --DNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPG 320
N + + ATLT++ + D+G Y C N+ GK+ +L VQE P ++
Sbjct: 7254 PGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEP 7313
Query: 321 PRIAAQIGDSVMLTCSVMGCESPSFSW---RTQIDSPLSGKVRSEGTNSTLTLSPVSFEN 377
RI Q + C + G W T+I ++ + + L + +S E+
Sbjct: 7314 SRIVKQ-DEFTRYECKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVED 7372
Query: 378 EHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLE 437
Y C E + G + SS ++ K P ++
Sbjct: 7373 SGDYTC------------------------EAHNAAGSAS-SSTSLKVKEPPIFRKKPHP 7407
Query: 438 IELLKGETILENIEFLEDT---------DMKSLEN----KSLEMTFIPTIEDTGKALVCQ 484
IE LKG + E L+ T D + L + K + F+ +I
Sbjct: 7408 IETLKGADVHLECE-LQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIH--------- 7457
Query: 485 AKLHIDDMEFEPKQRQSTQ---------TLYVNVAPRDTTVLVSPSSILEEGSSVNMTCL 535
L++D + Q ++T ++ + PR L S+++ G V +
Sbjct: 7458 -ILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDISTVV--GKEVQLQTT 7514
Query: 536 SQGFPAPKILWSRQLPNGELQPLSEN---------ATLTLISTKMEDSGVYLCEGINQAG 586
+G ++W + GE+ S+N ATL + ++G Y C+ N AG
Sbjct: 7515 IEGAEPISVVWFKD--KGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAG 7572
Query: 587 RSRKEVEL------IIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE--TWIILKKK 638
L I P+ IK+T GDT + CT PE T K
Sbjct: 7573 MQECFATLSVLEPATIVEKPESIKVTT--------GDTCTLECTVAGTPELSTKWFKDGK 7624
Query: 639 AETGDTVLK-----SIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGR 688
T D K + G I A D+GVY E +N VG + +L V R
Sbjct: 7625 ELTSDNKYKISFFNKVSGLKIINVAP-SDSGVYSFEVQNPVGKDSCTASLQVSDR 7678
Score = 75.1 bits (183), Expect = 2e-13
Identities = 151/710 (21%), Positives = 275/710 (38%), Gaps = 91/710 (12%)
Query: 18 MFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSW---RTQIDSPLNGKVTNE 74
+F A +E S+ L + GD+ L C TG +W +I +++
Sbjct: 4293 LFVKEPATFVEKLEPSQLLKK-GDATQLACKVTGTPPIKITWFANDREIKESSKHRMSFV 4351
Query: 75 GTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGK--P 132
+T+ L + V + Y+C A E+ V + P + P+E K
Sbjct: 4352 ESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKEF--KPIEVLKEYD 4409
Query: 133 ITVKCSVADVYPFDRLEIDLLKGDHLMKS----QEFLEDADRKSLETKSLEVTFTPVIED 188
+ + VA PF EI K + +++S + F++D SL++ V D
Sbjct: 4410 VMLLAEVAGTPPF---EITWFKDNTILRSGRKYKTFIQD------HLVSLQI-LKFVAAD 4459
Query: 189 IGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSS 248
G+ CR + S+ + R ++E P + + + ++ L+ GG+ +
Sbjct: 4460 AGE-YQCRVTNEVG--SSICSARVTLRE------PPSFIKKIESTSSLR-GGTAAFQATL 4509
Query: 249 EGLPAPEIFWSK------KLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRK 302
+G + W K + DN + + A+L L + ++ G YVC+ N G R
Sbjct: 4510 KGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRC 4569
Query: 303 EVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSW-RTQIDSPLSGKVRS 361
L V+E P T+ I GD L G + + W + + L K +
Sbjct: 4570 SALLSVKE-PATI-TEEAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGSKYKI 4627
Query: 362 EGTNSTLTLSPVSFE----NEHSYLCTVTCGHKKLEKGIQV-ELYSFPRDPEIEMSGGLV 416
T++ L +S E E+++ G + I V +L P + +
Sbjct: 4628 SVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPPSFTKKLKKMDSI 4687
Query: 417 NGSSVTVSCKVPSVYPLD----RLEIELLKGE----TILENIEFLEDTDMKSLENKSLEM 468
GS + + C V +P+ + + E+ E + +N FLE + ++ ++ +
Sbjct: 4688 KGSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGTY-- 4745
Query: 469 TFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGS 528
T T KA Q H+ E P + Q+ VN R
Sbjct: 4746 ----TCSATNKAGHNQCSGHLTVKE-PPYFVEKPQSQDVNPNTR---------------- 4784
Query: 529 SVNMTCLSQGFPAPKILW---SRQLPNGELQPLSENAT---LTLISTKMEDSGVYLCEGI 582
V + L G I W +++L +G + + ++ T L L + K DSG Y+C+
Sbjct: 4785 -VQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLS 4843
Query: 583 NQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETG 642
N G + + L ++ P+ IK + P ++ G + C P+ +
Sbjct: 4844 NDVGTATSKATLFVKEPPQFIKKPS-PVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEI 4902
Query: 643 DTVLKS----IDG--AYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 686
+ K IDG + I A+++++G Y CE++N G+ S+ L V+
Sbjct: 4903 TAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIELKVK 4952
Score = 70.1 bits (170), Expect = 7e-12
Identities = 130/611 (21%), Positives = 225/611 (36%), Gaps = 75/611 (12%)
Query: 39 IGDSVSLTCSTTGCESPFFSW---RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLC 95
+GDS SL C G SW T++ K+ +TL N V + Y+C
Sbjct: 7974 VGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYIC 8033
Query: 96 TATCESRKLEKG--IQVEIYSFPKDPEIHLSGPLE-AGKPITVKCSVADVYPFDRLEIDL 152
A ++ + V+ P L E G P+ C+++ P + +
Sbjct: 8034 KAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEP---ISVSW 8090
Query: 153 LKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLV----CRAKLHIDEMDS-- 206
K +K D +++T L+ T T I + L C A I S
Sbjct: 8091 YKDGKPLK--------DSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSA 8142
Query: 207 --VPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW---SKK 261
+ T + + ++P + V+ G S C G ++ W S++
Sbjct: 8143 RLILTEGKNPPFFDIRLAPVDAVV----------GESADFECHVTGTQPIKVSWAKDSRE 8192
Query: 262 LDNG---NLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEK----PFT 314
+ +G + +L +A LT++ + DSG Y C VN +GK+ +L ++E+ FT
Sbjct: 8193 IRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFT 8252
Query: 315 VEISPGPRIAAQIGDSVMLTCSVMGCESPSFSW-RTQIDSPLSGKVRSEGTNSTLTLS-- 371
+S + G+S L V G + + +W + I+ + N+TL L
Sbjct: 8253 KRLS--ETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNTLVLQVR 8310
Query: 372 PVSFENEHSYLCTVT--CGHKKLEKGIQVELYSFPRDPEIEMSGGLVN-GSSVTVSCKVP 428
+ Y C V+ G I ++ P + ++ V+ G V +SC V
Sbjct: 8311 KAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQ 8370
Query: 429 SVYPLDRLEIELLKGETILE-----NIEFLEDTDMKSLEN--KSLEMTFIPTIEDTGKAL 481
P + I+ LK ++ + F T + L + K+ ++ + +
Sbjct: 8371 GSEP---IRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSD 8427
Query: 482 VCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPA 541
++K+ I D K + T V R V S + E ++ G P
Sbjct: 8428 TTKSKVTIKD-----KPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPI 8482
Query: 542 PKILWS----RQLPNGE---LQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVEL 594
P + W+ RQL G + + A L + T DSG+Y C N+ G V L
Sbjct: 8483 PNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNL 8542
Query: 595 IIQVTPKDIKL 605
+ K K+
Sbjct: 8543 QVDERKKQEKI 8553
Score = 67.8 bits (164), Expect = 3e-11
Identities = 117/547 (21%), Positives = 210/547 (38%), Gaps = 85/547 (15%)
Query: 170 RKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYIS-PKNTVI 228
R S SLE+ T V+ D G+ C+A + T+ ++S PK+
Sbjct: 3505 RSSKYISSLEILRTQVV-DCGEY-TCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTT 3562
Query: 229 SVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK------LDNGNLQHLSGNATLTLIAMR 282
V + K C+ G P E W K N + L L +
Sbjct: 3563 FVGKAAKF--------ICTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLT 3614
Query: 283 MEDSGIYVCEGVNLIGKNRKEVELIVQEKP-FTVEISPGPRIAAQIGDSVMLTCSVMGCE 341
++D G+Y C+ N G + + ELI+ +KP F E+ P + + I V L C V
Sbjct: 3615 IQDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEP---VQSAINKKVHLECQVDEDR 3671
Query: 342 SPSFSWRTQIDSPLSG---KVRSEGTNSTLTLSPVSFENEHSYLCTVT--CGHKKLEKGI 396
+ +W G K+ E +TL + ++ +Y+CT + G +
Sbjct: 3672 KVTVTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSATV 3731
Query: 397 QV-ELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLED 455
V E SF + +++ S ++ G S + CK LKG +++ F +
Sbjct: 3732 TVREPPSFVK--KVDPSYLMLPGESARLHCK--------------LKGSPVIQVTWFKNN 3775
Query: 456 TDMKSLENKSLEMTFIPT----------IEDTGKALVCQAKLHIDDMEFEPKQRQSTQTL 505
++ E+ ++ M F+ + +ED+G + C+A ++D+ + S T
Sbjct: 3776 KELS--ESNTVRMYFVNSEAILDITDVKVEDSG-SYSCEA---VNDVGSD-----SCSTE 3824
Query: 506 YVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGELQPLSENA 562
V P + P+ I+ G++ + C G +I W +Q+ + + L
Sbjct: 3825 IVIKEPPSFIKTLEPADIV-RGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQK 3883
Query: 563 TLT---LISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIK----LTAFPSESVKE 615
+L + S D G Y C N+ G+ +++ P +K L A ++V
Sbjct: 3884 SLVCLEIFSFNSADVGEYECVVANEVGKCGCMATHLLKEPPTFVKKVDDLIALGGQTV-- 3941
Query: 616 GDTVIISCTCGNVP--ETWIILKKKAETGDTVLKSIDGAYT---IRKAQLKDAGVYECES 670
+ + G+ P TW+ ++ + S I Q+ G Y C +
Sbjct: 3942 ---TLQAAVRGSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLA 3998
Query: 671 KNKVGSQ 677
+N+ GSQ
Sbjct: 3999 ENEAGSQ 4005
Score = 67.0 bits (162), Expect = 6e-11
Identities = 144/684 (21%), Positives = 242/684 (35%), Gaps = 82/684 (11%)
Query: 40 GDSVSLTCSTTGCESPFFSW---RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCT 96
G + L C G W +I + K + T+ L ++ + + +Y C+
Sbjct: 4689 GSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTCS 4748
Query: 97 ATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGD 156
AT ++ + + + P E S + + +K V P K
Sbjct: 4749 ATNKAGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKEL 4808
Query: 157 HLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKE 216
H ++ +D SLE + + T D G +C+ + S T+ VKE
Sbjct: 4809 HSGAARSVWKDDTSTSLELFAAKAT------DSG-TYICQLSNDVGTATSKATL--FVKE 4859
Query: 217 LQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWS------KKLDNGNLQHL 270
P + +P L+ G S T C G P + W + + +
Sbjct: 4860 ------PPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFI 4913
Query: 271 SGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKP-FTVEISPGPRIAAQIGD 329
G AT + R+E+SG YVCE N G +EL V+E P F E+ P +
Sbjct: 4914 DGLATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPPTFIRELKP---VEVVKYS 4970
Query: 330 SVMLTCSVMGCESPSFSW---RTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVT 386
V L C V G +W +I S + + L ++ + Y C V+
Sbjct: 4971 DVELECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVS 5030
Query: 387 CGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETI 446
+V L P + + V SS T V P + I LK + I
Sbjct: 5031 NEGGSCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQSTVAGSPP---ISITWLKDDQI 5087
Query: 447 LENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLY 506
L+ E+ ++ ++F+ ++ A L I ++ R + Q
Sbjct: 5088 LD-------------EDDNVYISFVDSV----------ATLQIRSVDNGHSGRYTCQAKN 5124
Query: 507 VNVAPRDTTVLV--SPSSILEEGSSVNMT--------CLSQGFPAPKILWSRQ----LPN 552
+ R L+ P+ I+E+ SV++T C+ G P K+ W + +P+
Sbjct: 5125 ESGVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVVAGTPELKVKWLKDGKQIVPS 5184
Query: 553 GELQPLSEN--ATLTLISTKMEDSGVYLCEGINQAGRSRKEVELII--QVTPKDIKLTAF 608
EN A+ + S +DSG Y + N G S + L + Q P
Sbjct: 5185 RYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSFTKKLT 5244
Query: 609 PSESVKEGDTVIISC-TCGNVP--ETWIILKKKAETG---DTVLKSIDGAYTIRKAQLKD 662
+ V G ++ + C G++P W K+ T V + + +L+D
Sbjct: 5245 KMDKVL-GSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELED 5303
Query: 663 AGVYECESKNKVGSQLRSLTLDVQ 686
Y C+ N G S L V+
Sbjct: 5304 TANYTCKVSNVAGDDACSGILTVK 5327
Score = 67.0 bits (162), Expect = 6e-11
Identities = 151/693 (21%), Positives = 260/693 (37%), Gaps = 100/693 (14%)
Query: 32 ESRYLAQIGDSVSLTCSTTGCESPFFSW---RTQIDSPLNGKVTNEGTTSTLTMNPVSFG 88
E+ +A+ G+S+ L C +G SW +++ ++ + + LT+N S
Sbjct: 6371 EASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFINSVALLTINEASAE 6430
Query: 89 NEHSYLCTA-------TCESRKLEKGIQVEIYSFPKDPEIHLSGPLEA--GKPITVKCSV 139
+ Y+C A +C + K V F + P P+ A G + ++C +
Sbjct: 6431 DSGDYICEAHNGVGDASCSTALTVKAPPV----FTQKPS-----PVGALKGSDVILQCEI 6481
Query: 140 ADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKL 199
+ PF+ + + K K + SL +LE + D+G+ C+A
Sbjct: 6482 SGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHILNLEAS------DVGEYH-CKATN 6534
Query: 200 HIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWS 259
+ T +VK + P V ++ ++ L G +V + EG + W
Sbjct: 6535 EVGS----DTCSCSVK----FKEPPRFVKKLSDTSTLI-GDAVELRAIVEGFQPISVVWL 6585
Query: 260 K-------KLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKP 312
K + +N + + ATL L + +SG Y+C+ N G L V E
Sbjct: 6586 KDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPA 6645
Query: 313 FTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSP 372
+E P P + G+ L C V G S W G+ S + +T
Sbjct: 6646 RIIE-KPEP-MTVTTGNPFALECVVTGTPELSAKWFK------DGRELSADSKHHIT--- 6694
Query: 373 VSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGS-SVTVSCK-VPSV 430
F N+ + L + C +KG LYSF E++ S G N + SV VS + VP
Sbjct: 6695 --FINKVASL-KIPCAEMS-DKG----LYSF----EVKNSVGKSNCTVSVHVSDRIVPPS 6742
Query: 431 YPLDRLEIELLKGETILENIEFLEDTDMK-SLENKSLEMTFIPTIEDTGKALVCQAKLHI 489
+ ++ + G +++ + E+ P + + VC L +
Sbjct: 6743 FIRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSL 6802
Query: 490 DDMEFEPKQRQSTQTLYVNVAPRDTTVLV-----------SPSSI-LEEGSSVNMTCLSQ 537
EP + NVA D V +P S+ + G S+ T + +
Sbjct: 6803 ----LEPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSVIR 6858
Query: 538 GFPAPKILW---SRQLPNGELQPLSEN---ATLTLISTKMEDSGVYLCEGINQAGRSRKE 591
G P K+ W SR+L GE +S L L + +SG Y C N AG +
Sbjct: 6859 GTPPFKVKWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCT 6918
Query: 592 VELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWI---ILKKKAETGDTV 645
L ++ +K A SV+ G +++ T P +WI L ++E
Sbjct: 6919 THLFVKEPATFVKRLA--DFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSIT 6976
Query: 646 LKSIDGAYTIRKAQLKDAGVYECESKNKVGSQL 678
+ I ++ ++D Y C +N+ G +
Sbjct: 6977 MTEKSTILEILESTIEDYAQYSCLIENEAGQDI 7009
Score = 67.0 bits (162), Expect = 6e-11
Identities = 149/690 (21%), Positives = 255/690 (36%), Gaps = 88/690 (12%)
Query: 40 GDSVSLTCSTTGCESPFFSW---RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCT 96
G V L C +G W R Q+ + K+T++ ++L + + + Y C
Sbjct: 6472 GSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCK 6531
Query: 97 ATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGD 156
AT E V+ P+ K S D +E+ +
Sbjct: 6532 ATNEVGSDTCSCSVKFKEPPR---------------FVKKLSDTSTLIGDAVELRAIVEG 6576
Query: 157 HLMKSQEFLEDADRKSLETKSLEVTFTPVIE--DIGKVLVCRAKLHIDEMDSVPTVRQAV 214
S +L+D E+++ ++F I +G + +I ++ + +R+
Sbjct: 6577 FQPISVVWLKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECS 6636
Query: 215 KELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSK---KLDNGNLQHLS 271
L V + P + P T + G + C G P W K +L + H++
Sbjct: 6637 AVLTV-LEPARIIEKPEPMT-VTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHIT 6694
Query: 272 ---GNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVE-ISPGPRIAAQI 327
A+L + M D G+Y E N +GK+ V + V ++ I + A +
Sbjct: 6695 FINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAIL 6754
Query: 328 GDSVMLTCSVMGCESPSFSWRTQIDSPLSG-KVRSEGTNS--TLTLSPVSFENEHSYLCT 384
G SV+L C V G S W + +SG K +S + + TL LS + + Y C
Sbjct: 6755 GASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCV 6814
Query: 385 VT--CGHKKLEKGIQV-ELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLD----RLE 437
G + + V E SF + P+ S ++ G S+T + + P +
Sbjct: 6815 AANVAGSDECSAVLTVQEPPSFEQTPD---SVEVLPGMSLTFTSVIRGTPPFKVKWFKGS 6871
Query: 438 IELLKGETILENIEFLED--TDMKSLENKSLEMTFIPTI--EDTGKALVCQAKLHIDDME 493
EL+ GE+ NI LED T+++ E + LE + D G A
Sbjct: 6872 RELVPGESC--NIS-LEDFVTELELFEVQPLESGDYSCLVTNDAGSA------------- 6915
Query: 494 FEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSR----- 548
+ T ++ V T V +E GS + + G P + W +
Sbjct: 6916 --------SCTTHLFVKEPATFVKRLADFSVETGSPIVLEATYTGTPPISVSWIKDEYLI 6967
Query: 549 -QLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTA 607
Q + ++ L ++ + +ED Y C N+AG+ E + + P I+
Sbjct: 6968 SQSERCSITMTEKSTILEILESTIEDYAQYSCLIENEAGQDICEALVSVLEPPYFIE--- 7024
Query: 608 FPSESVKE--GDTVIISCTCGNVPETWIILKKK------AETGDTVLKSIDGAYTIRKAQ 659
P E V+ G+ + C PE I K+ A K+ + I K
Sbjct: 7025 -PLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVD 7083
Query: 660 LKDAGVYECESKNKVGSQLRSLTLDVQGRE 689
D G Y C++ N VG+ S L ++ R+
Sbjct: 7084 HSDVGEYSCKADNSVGAVASSAVLVIKARK 7113
Score = 65.1 bits (157), Expect = 2e-10
Identities = 116/531 (21%), Positives = 192/531 (36%), Gaps = 88/531 (16%)
Query: 194 VCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPA 253
+C+A+L I + +KEL+ S N V+ ++ E VT+T S +G
Sbjct: 3633 ICQAELIIIDKPHF------IKELEPVQSAINK--KVHLECQVDEDRKVTVTWSKDGQKL 3684
Query: 254 P-----EIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIV 308
P +I + K+ ATL + +++DSG YVC N G + + V
Sbjct: 3685 PPGKDYKICFEDKI-----------ATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTV 3733
Query: 309 QEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSW-RTQIDSPLSGKVRSEGTNST 367
+E P V+ P G+S L C + G +W + + S VR NS
Sbjct: 3734 REPPSFVK-KVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSE 3792
Query: 368 --LTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSC 425
L ++ V E+ SY C ++ + P + +V G++ + C
Sbjct: 3793 AILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPPSFIKTLEPADIVRGTNALLQC 3852
Query: 426 KVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQA 485
+V P EI K D K + + F + K+LVC
Sbjct: 3853 EVSGTGPF---EISWFK--------------DKKQIRSSKKYRLF------SQKSLVC-- 3887
Query: 486 KLHIDDMEFEPKQRQSTQTLYVNVAPR----DTTVLVSPSSILEE--------GSSVNMT 533
++ F + + N + T +L P + +++ G +V +
Sbjct: 3888 ---LEIFSFNSADVGEYECVVANEVGKCGCMATHLLKEPPTFVKKVDDLIALGGQTVTLQ 3944
Query: 534 CLSQGFPAPKILWSRQLP----NGELQPLSENATLTLISTKMEDS--GVYLCEGINQAGR 587
+G + W + +G+++ N LI ++ S G Y C N+AG
Sbjct: 3945 AAVRGSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGS 4004
Query: 588 SRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPET---W------IILKKK 638
ELI++ K I+ V GD + T PE W ++ KK
Sbjct: 4005 QTSVGELIVKEPAKIIERAELIQ--VTAGDPATLEYTVAGTPELKPKWYKDGRPLVASKK 4062
Query: 639 AETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRE 689
K+ A+L D+G Y E N+VGS T V R+
Sbjct: 4063 YRIS---FKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRD 4110
Score = 65.1 bits (157), Expect = 2e-10
Identities = 100/494 (20%), Positives = 184/494 (37%), Gaps = 55/494 (11%)
Query: 223 PKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK------LDNGNLQHLSGNATL 276
P V + S ++ G S + C G P + W + D + + A +
Sbjct: 5422 PPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVI 5481
Query: 277 TLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCS 336
+ + EDSG ++CE N G ++IV+E P V S P + V L C
Sbjct: 5482 QMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEPP--VFSSFPPIVETLKNAEVSLECE 5539
Query: 337 VMGCESPSFSW---RTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLE 393
+ G W + Q+ S K+ S+ ++++ + V + Y C
Sbjct: 5540 LSGTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDT 5599
Query: 394 KGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFL 453
V+L PR S +V G + + P+ +++L
Sbjct: 5600 CVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPI---------------FVQWL 5644
Query: 454 EDTDMKSLENKSLEMTFIPTIE--DTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAP 511
++ + E++++ +TF+ + KA A +I ++ + R++ TL V + P
Sbjct: 5645 KEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMV-LEP 5703
Query: 512 RDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSEN---------A 562
P ++ G + + C G P + W + +G+L S+ +
Sbjct: 5704 AVIVEKAGPMTV-TVGETCTLECKVAGTPELSVEWYK---DGKLLTSSQKHKFSFYNKIS 5759
Query: 563 TLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIIS 622
+L ++S + +D+G Y + N G+S ++ V+ + + +F G + S
Sbjct: 5760 SLRILSVERQDAGTYTFQVQNNVGKS--SCTAVVDVSDRAVP-PSFTRRLKNTGGVLGAS 5816
Query: 623 C-----TCGNVP--ETWIILKKKAETGDTVLKSI-DGAYTIRKAQL--KDAGVYECESKN 672
C G+ P W K K +G + D T++ L D G Y C + N
Sbjct: 5817 CILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAAN 5876
Query: 673 KVGSQLRSLTLDVQ 686
GS L VQ
Sbjct: 5877 VAGSDECRAVLTVQ 5890
Score = 64.3 bits (155), Expect = 4e-10
Identities = 113/495 (22%), Positives = 184/495 (37%), Gaps = 57/495 (11%)
Query: 223 PKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLS--------GNA 274
P + + PS +++ C G P ++ W K D +Q S A
Sbjct: 7304 PPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYK--DETEIQESSKFRMSFVDSVA 7361
Query: 275 TLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLT 334
L + + +EDSG Y CE N G L V+E P P P I G V L
Sbjct: 7362 VLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKEPPI-FRKKPHP-IETLKGADVHLE 7419
Query: 335 CSVMGCESPSFSW---RTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKK 391
C + G SW + ++ S K+ SE +++ + V + Y C T
Sbjct: 7420 CELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGS 7479
Query: 392 LEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILE--N 449
+ L + PR + V G V + + P+ + + KGE + E N
Sbjct: 7480 DTCVGSIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFK-DKGEIVRESDN 7538
Query: 450 IEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNV 509
I ++ +L+ +E + GK CQ K + ++ TL V
Sbjct: 7539 IWISYSENIATLQFSRVEPA------NAGK-YTCQIK-------NDAGMQECFATLSV-- 7582
Query: 510 APRDTTVLVSPSSI-LEEGSSVNMTCLSQGFPAPKILW---SRQLPNGELQPLS---ENA 562
T++ P SI + G + + C G P W ++L + +S + +
Sbjct: 7583 -LEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKVS 7641
Query: 563 TLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKE-----GD 617
L +I+ DSGVY E N G+ L QV+ + + + + +KE G
Sbjct: 7642 GLKIINVAPSDSGVYSFEVQNPVGKDSCTASL--QVSDRTVPPSF--TRKLKETNGLSGS 7697
Query: 618 TVIISCTCGNVPE---TWIILKKKAETG---DTVLKSIDGAYTIRKAQLKDAGVYECESK 671
+V++ C P +W + +G T L A T+ + D+G Y C +
Sbjct: 7698 SVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIAT 7757
Query: 672 NKVGSQLRSLTLDVQ 686
N GS S L V+
Sbjct: 7758 NMAGSDECSAPLTVR 7772
Score = 64.3 bits (155), Expect = 4e-10
Identities = 118/531 (22%), Positives = 181/531 (34%), Gaps = 97/531 (18%)
Query: 195 CRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAP 254
C A L + + P+ + +KE T G SV M C G P
Sbjct: 7669 CTASLQVSDRTVPPSFTRKLKE-----------------TNGLSGSSVVMECKVYGSPPI 7711
Query: 255 EIFW---SKKLDNGNLQHLS---GNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIV 308
+ W ++ +G + LT+ + DSG Y C N+ G + L V
Sbjct: 7712 SVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTV 7771
Query: 309 QEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSG---KVRSEGTN 365
+E P V+ P P + G +V T V G S SW + G V E +
Sbjct: 7772 REPPSFVQ-KPDP-MDVLTGTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSV 7829
Query: 366 STLTLSPVSFENEHSYLCTVT--CGHKKLEKGIQVEL----------YSFPRDPEIEMSG 413
+ L L V Y C V+ G + ++ YS + + + G
Sbjct: 7830 AELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEG 7889
Query: 414 GLVNGSSVTVSCKVP--SVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFI 471
++V+ K +V P R I + ILE I
Sbjct: 7890 TFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILE----------------------I 7927
Query: 472 P--TIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSS 529
P T+ED G Q +I++ K S Q L + P + P + G S
Sbjct: 7928 PSSTVEDAG-----QYNCYIENA--SGKDSCSAQILILE--PPYFVKQLEPVKV-SVGDS 7977
Query: 530 VNMTCLSQGFPAPKILW------SRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGIN 583
++ C G P + W R ++ + ATL + DSG Y+C+ N
Sbjct: 7978 ASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAEN 8037
Query: 584 QAGRSRKEVELIIQVTPKDIKLTAFPSESVKE-----GDTVIISCTCGN---VPETWIIL 635
G EV +T ++ KL S +++ G V+ C + +W
Sbjct: 8038 SVG----EVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKD 8093
Query: 636 KKKAETGDTVLKS-IDGAYTIR--KAQLKDAGVYECESKNKVGSQLRSLTL 683
K + V S +D T+ K AG Y C + N +GS S L
Sbjct: 8094 GKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARL 8144
Score = 62.0 bits (149), Expect = 2e-09
Identities = 119/531 (22%), Positives = 185/531 (34%), Gaps = 69/531 (12%)
Query: 223 PKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK---LDNG---NLQHLSGNATL 276
P + + P T +Q G G P P+I W K+ L G H TL
Sbjct: 3238 PPQVLQELQPVT-VQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTL 3296
Query: 277 TLIAMRMEDSGIYVCEGVNLIGKNRKEVELIV---------QEKPF--TVEISPGPRIAA 325
LI ED+ +Y CE N G L V QE P I+P
Sbjct: 3297 LLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVT 3356
Query: 326 QIGDSVMLTCSVMGCE------------SPSFSWR-TQIDSPLSGKV-----RSEGTNST 367
G C V G + PS +R TQ + ++ EGT +
Sbjct: 3357 SEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTF 3416
Query: 368 LT---LSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVS 424
+ + VS S + H+++E+ I++E+ + P + G +
Sbjct: 3417 VASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFT 3476
Query: 425 CKVPSVYPLDRLEIELLK-GETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVC 483
C++ S + + K G I E+ + ++S + S + D G+ C
Sbjct: 3477 CEIQSA---PNVRFQWFKAGREIYES----DKCSIRSSKYISSLEILRTQVVDCGE-YTC 3528
Query: 484 QAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPK 543
+A + T TL V A T + S G + C G P +
Sbjct: 3529 KASNEYGSVS-------CTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIE 3581
Query: 544 ILWSRQ------LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQ 597
+W + PN + L L + ++D GVY C+ N+ G + ELII
Sbjct: 3582 TIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKFGADICQAELIII 3641
Query: 598 VTPKDIKLTAFPSESVKEGDTVIISCTCG---NVPETWIILKKKAETGDTVLKSID---G 651
P IK ++ + V + C V TW +K G +
Sbjct: 3642 DKPHFIKELEPVQSAINK--KVHLECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKIA 3699
Query: 652 AYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVL 702
I A+LKD+G Y C + N+ GS S T+ V+ + P L+L
Sbjct: 3700 TLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPSFVKKVDPSYLML 3750
Score = 58.5 bits (140), Expect = 2e-08
Identities = 148/723 (20%), Positives = 268/723 (37%), Gaps = 138/723 (19%)
Query: 37 AQIGDSVSLTCSTTGCESPFFSWRT---QIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSY 93
A +G+S C TG + SW +I S +++ ++ LT+ V G+ Y
Sbjct: 8164 AVVGESADFECHVTGTQPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQY 8223
Query: 94 LCTATCESRKLEKGIQVEIY------SFPK----------DPEIHLSGPLEAGKPITVKC 137
C A E K Q+ I SF K L G + +PITV
Sbjct: 8224 TCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAW 8283
Query: 138 --SVADVYPFDRLEIDLLKGDHLMKSQEF-LEDADRKSLETKSLEVTFTPVIEDIGKVLV 194
+ ++ P EI +++ ++ + DA + + V D G L
Sbjct: 8284 YKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCK----------VSNDAGSAL- 8332
Query: 195 CRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAP 254
C + + I E P Q + + V EG V ++C +G
Sbjct: 8333 CTSSIVIKEPKKPPVFDQHLTPVTV-----------------SEGEYVQLSCHVQGSEPI 8375
Query: 255 EIFWSKK------LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIV 308
I W K D + SG A L L + DSG YVC+ N+ G + + ++ +
Sbjct: 8376 RIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTI 8435
Query: 309 QEKPFTVEISPGPRIAAQIG----------------DSVMLTCSVMGCESPSFSWR---- 348
++KP ++P + AA G + V G P+ W
Sbjct: 8436 KDKP---AVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWTKGKW 8492
Query: 349 TQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPE 408
Q++ + +G + L + + + Y C H ++E + +++ + +
Sbjct: 8493 RQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQVDERKKQEK 8552
Query: 409 IEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKG---ETILENIEFLEDTDMKSLENKS 465
IE G + K P L KG E ++ +E L++ D K E K
Sbjct: 8553 IE-------GDLRAMLKKTPI----------LKKGAGEEEEIDIMELLKNVDPKEYE-KY 8594
Query: 466 LEMTFIPTIEDTGKA--LVCQA------KLHIDDMEFEPKQRQSTQTLYVNVAPR----- 512
M I +A L+ Q+ +L I+++E + + + L + R
Sbjct: 8595 ARMYGITDFRGLLQAFELLKQSQEEETHRLEIEEIERSERDEKEFEELVSFIQQRLSQTE 8654
Query: 513 DTTVL--VSPSSILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGELQPLS---ENATL 564
T++ + ++L++ +V + +P K+ W + +L + +S + TL
Sbjct: 8655 PVTLIKDIENQTVLKDNDAVFEIDIKINYPEIKLSWYKGTEKLEPSDKFEISIDGDRHTL 8714
Query: 565 TLISTKMEDSGVY-LCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISC 623
+ + +++D G Y L G + A +E + +D+ L KEG T ++C
Sbjct: 8715 RVKNCQLKDQGNYRLVCGPHIASAKLTVIEPAWERHLQDVTL--------KEGQTCTMTC 8766
Query: 624 --TCGNVPETWI----ILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKN-KVGS 676
+ NV W ILK + V + TI + +D G Y C+ ++ + +
Sbjct: 8767 QFSVPNVKSEWFRNGRILKPQGRHKTEVEHKVH-KLTIADVRAEDQGQYTCKYEDLETSA 8825
Query: 677 QLR 679
+LR
Sbjct: 8826 ELR 8828
Score = 57.4 bits (137), Expect = 5e-08
Identities = 96/487 (19%), Positives = 184/487 (37%), Gaps = 69/487 (14%)
Query: 227 VISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDN------GNLQHLSGNATLTLIA 280
++ S + E +T+ C G P ++ W K ++ + A+ + +
Sbjct: 5143 IVEKAKSVDVTEKDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQS 5202
Query: 281 MRMEDSGIYVCEGVNLIGKNRKEVELIVQEK----PFTVEISPGPRIAAQIGDSVMLTCS 336
+ +DSG Y + N G + + L V ++ FT +++ ++ +G S+ + C
Sbjct: 5203 VMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKV---LGSSIHMECK 5259
Query: 337 VMGCESPSFSW---RTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVT--CGHKK 391
V G S W +I + ++ + +L ++ + E+ +Y C V+ G
Sbjct: 5260 VSGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDA 5319
Query: 392 LEKGIQV-ELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLD----RLEIELLKGETI 446
+ V E SF P + + + S+V + P + ++EL+ G
Sbjct: 5320 CSGILTVKEPPSFLVKPGRQQA---IPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPKC 5376
Query: 447 LENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLY 506
+E T +L + T T T S T+
Sbjct: 5377 FIGLE--GSTSFLNLYSVDASKTGQYTCHVTNDV-----------------GSDSCTTML 5417
Query: 507 VNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTL 566
+ P + S I++ G S + C G P +++W R N P S+ +T
Sbjct: 5418 LVTEPPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFR---NEHELPASDKYRMTF 5474
Query: 567 IST---------KMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPS--ESVKE 615
I + EDSG ++CE N AG + ++I++ P ++FP E++K
Sbjct: 5475 IDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEPP---VFSSFPPIVETLKN 5531
Query: 616 GDTVIISCTCGNVPETWIILKK------KAETGDTVLKSIDGAYTIRKAQLKDAGVYECE 669
+ V + C P ++ K ++ K+ + I D G Y C+
Sbjct: 5532 AE-VSLECELSGTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCK 5590
Query: 670 SKNKVGS 676
++N+VGS
Sbjct: 5591 AQNEVGS 5597
Score = 54.7 bits (130), Expect = 3e-07
Identities = 136/626 (21%), Positives = 227/626 (36%), Gaps = 106/626 (16%)
Query: 127 LEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPV- 185
+ G +++C +A + + KGD ++ + R ++ T + F V
Sbjct: 7972 VSVGDSASLQCQLAGT---PEIGVSWYKGDTKLRPTTTYKMHFRNNVAT----LVFNQVD 8024
Query: 186 IEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMT 245
I D G+ +C+A+ + E+ + + V+E ++ S + V + L V
Sbjct: 8025 INDSGEY-ICKAENSVGEVSASTFL--TVQEQKLPPSFSRQLRDVQETVGLP----VVFD 8077
Query: 246 CSSEGLPAPEIFWSKK----LDNGNLQ--HLSGNATLTLIAMRMEDSGIYVCEGVNLIGK 299
C+ G + W K D+ N+Q L ATL + +G Y C N IG
Sbjct: 8078 CAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGS 8137
Query: 300 NRKEVELIVQEKP----FTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPL 355
LI+ E F + ++P + A +G+S C V G + SW
Sbjct: 8138 ASSSARLILTEGKNPPFFDIRLAP---VDAVVGESADFECHVTGTQPIKVSWAKD----- 8189
Query: 356 SGKVRSEG--------TNSTLTLSPVSFENEHSYLCTVT--CGHKKLEKGIQVELYSFPR 405
S ++RS G ++ LT+ V + Y C G + ++ P
Sbjct: 8190 SREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPP 8249
Query: 406 DPEIEMSGGL--VNGSSVTVSCKVPSVYPL------DRLEIELLKGETILENIEFLEDTD 457
+S + G+S + +V P+ + +EI+ T I F +T
Sbjct: 8250 SFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQ----PTSNCEITFKNNTL 8305
Query: 458 MKSLENKSLEMTFIPTIE---DTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDT 514
+ + + + T + D G AL C + + I + + P Q T
Sbjct: 8306 VLQVRKAGMNDAGLYTCKVSNDAGSAL-CTSSIVIKEPKKPPVFDQHL-----------T 8353
Query: 515 TVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQP--------LSENATLTL 566
V VS EG V ++C QG +I W + E++P S A L L
Sbjct: 8354 PVTVS------EGEYVQLSCHVQGSEPIRIQWLKA--GREIKPSDRCSFSFASGTAVLEL 8405
Query: 567 ISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTA---------FPSES----V 613
DSG Y+C+ N AG + ++ I+ P T F SE V
Sbjct: 8406 RDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRV 8465
Query: 614 KEGDTVIISCTCGNVP---ETWIILK-KKAETGDTVL---KSIDGAYTIRKAQLKDAGVY 666
E T G P W K ++ G V K + IR D+G+Y
Sbjct: 8466 VEKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLY 8525
Query: 667 ECESKNKVGSQLRSLTLDVQGRENNK 692
C + N+ G ++ L V R+ +
Sbjct: 8526 RCVAFNEHGEIESNVNLQVDERKKQE 8551
Score = 52.0 bits (123), Expect = 2e-06
Identities = 45/187 (24%), Positives = 77/187 (41%), Gaps = 21/187 (11%)
Query: 521 SSILEEGSSVNMTCLSQGFPAPKILWSRQ--------LPNGELQPLSENATLTLISTKME 572
S ++ EGS+ GFP P++ W R LP ++ A LT+ +
Sbjct: 14 SVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKA 73
Query: 573 DSGVYLCEGINQAGRSRKEVELIIQV-TPKDIKLTAFPSESVKEGDTVIISCTCGNVPET 631
+SG Y + N +G++ EL+++ T + S +V++G V + +P
Sbjct: 74 NSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTP 133
Query: 632 WIILKKKAETGDTVLKSID---------GAYTIRKAQLKDAGVYECESKNKVGSQLRSLT 682
+ K G + S+D + I +A +D+G Y + N VG +
Sbjct: 134 VV---KFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAE 190
Query: 683 LDVQGRE 689
L VQG E
Sbjct: 191 LLVQGEE 197
Score = 51.6 bits (122), Expect = 3e-06
Identities = 141/676 (20%), Positives = 265/676 (39%), Gaps = 116/676 (17%)
Query: 63 IDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSF--PKDP- 119
+D N ++ + +TL + V G+ Y C A K E G++ Y+F ++P
Sbjct: 5088 LDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQA-----KNESGVE-RCYAFLLVQEPA 5141
Query: 120 ---EIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLK-GDHLMKSQEFLEDAD------ 169
E S + P+T++C VA L++ LK G ++ S+ F +
Sbjct: 5142 QIVEKAKSVDVTEKDPMTLECVVAGT---PELKVKWLKDGKQIVPSRYFSMSFENNVASF 5198
Query: 170 --RKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTV 227
+ ++ S + TF V D G C A L + + + P+ + + ++ +
Sbjct: 5199 RIQSVMKQDSGQYTFK-VENDFGSSS-CDAYLRVLDQNIPPSFTKKLTKMDKVL------ 5250
Query: 228 ISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW---SKKLDNGNLQHL---SGNATLTLIAM 281
G S+ M C G W K++ L + +L + +
Sbjct: 5251 -----------GSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNL 5299
Query: 282 RMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCE 341
+ED+ Y C+ N+ G + L V+E P + + PG + A I DS + +++
Sbjct: 5300 ELEDTANYTCKVSNVAGDDACSGILTVKEPP-SFLVKPGRQQA--IPDSTVEFKAILKGT 5356
Query: 342 SP-SFSWRTQIDSPLSGK---VRSEGTNSTLTLSPVSFENEHSYLCTVT--CGHKKLEKG 395
P W +SG + EG+ S L L V Y C VT G
Sbjct: 5357 PPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTM 5416
Query: 396 IQV-ELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLE 454
+ V E F + ++E S + G S + CK+ G + + F
Sbjct: 5417 LLVTEPPKFVK--KLEASKIVKAGDSSRLECKI--------------AGSPEIRVVWFRN 5460
Query: 455 DTDMKSLENKSLEMTFIPTI----------EDTGKALVCQAKLHIDDMEFEPKQRQSTQT 504
+ ++ + + MTFI ++ ED+G +C+A+ P S T
Sbjct: 5461 EHELPA--SDKYRMTFIDSVAVIQMNNLSTEDSGD-FICEAQ--------NPAGSTSCST 5509
Query: 505 LYVNVAPRDTTVLVSPSSILE--EGSSVNMTCLSQGFPAPKILW---SRQLPNGELQPLS 559
V ++ V S I+E + + V++ C G P +++W RQL + + ++
Sbjct: 5510 ---KVIVKEPPVFSSFPPIVETLKNAEVSLECELSGTPPFEVVWYKDKRQLRSSKKYKIA 5566
Query: 560 E---NATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEG 616
+ ++ +++ D G Y C+ N+ G + ++ P+ + + S +V G
Sbjct: 5567 SKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLKEPPRFV--SKLNSLTVVAG 5624
Query: 617 DTVIISCTCGNVPETWI-ILKKK----AETGDTVLKSIDGAYTIR--KAQLKDAGVYECE 669
+ + + ++ LK+K E+ + + ++ T++ KA+ +AG Y C+
Sbjct: 5625 EPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYICQ 5684
Query: 670 SKNKVGSQLRSLTLDV 685
KN G + TL V
Sbjct: 5685 IKNDGGMRENMATLMV 5700
Score = 50.8 bits (120), Expect = 4e-06
Identities = 92/472 (19%), Positives = 186/472 (39%), Gaps = 58/472 (12%)
Query: 161 SQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCR-----AKLHIDEM---DSVPTVRQ 212
SQ+ L + K E KS E + E+ KVL+ A +++ + + Q
Sbjct: 32973 SQKALRSEEIKMSEAKSQEKL--ALKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQ 33030
Query: 213 AVKELQVYISPK--NTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW---SKKLDNGNL 267
A +E++ + K +T +S+N EG + + + G A ++ W +L N
Sbjct: 33031 ASEEVRTHAEIKAFSTQMSIN------EGQRLVLKANIAG--ATDVKWVLNGVELTNSEE 33082
Query: 268 QH--LSGN-ATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIA 324
+SG+ TLT+ D GI C I K ++ + + + E+S P
Sbjct: 33083 YRYGVSGSDQTLTIKQASHRDEGILTC-----ISKTKEGIVKCQYDLTLSKELSDAPAFI 33137
Query: 325 AQI-------GDSVMLTCSVMGCESPSFSW-RTQIDSPLSGKVRSEGTNSTLTLSPVSFE 376
+Q G +V+ TC + G SP W + + +S V + + +L +
Sbjct: 33138 SQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNAS 33197
Query: 377 NEHSYLCTVTCGHKKLEKGIQVELYSFP--RDPEIEMSGGLVNGSSVTVSCKVPSVYPLD 434
S T+ + + + L P +P E+ +S+ S SV
Sbjct: 33198 VSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQSV---- 33253
Query: 435 RLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEF 494
++ K E + + M ++ S+ + +++++ + + + I +M
Sbjct: 33254 --QMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMT- 33310
Query: 495 EPKQRQSTQTLYVNVAPRDTTVLVSPSSI-LEEGSSVNMTCLSQGFPAPKILWS---RQL 550
+ +++ L + + PS I ++EG + + C G P P++ WS R++
Sbjct: 33311 -QLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKI 33369
Query: 551 PNGE-----LQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQ 597
+ E ++ + TL ++ + +D G+Y N+ G V + I+
Sbjct: 33370 HSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIR 33421
Score = 47.8 bits (112), Expect = 4e-05
Identities = 103/499 (20%), Positives = 180/499 (36%), Gaps = 117/499 (23%)
Query: 178 LEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQ 237
+ +T T V E+ +VL R + + E VP +++ ++P T++S + +
Sbjct: 904 VSITGTTVREERFEVLHGR-EAKVTETARVPA------PVEIPVTPP-TLVSGLKNVTVI 955
Query: 238 EGGSVTMTCSSEGLPAPEIFWSK---KLDNG---NLQHLSGNATLTLIAMRMEDSGIYVC 291
EG SVT+ C G P+P + W + ++++ + SG A L + EDSG + C
Sbjct: 956 EGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTC 1015
Query: 292 EGVNLIGKNRKEVELIVQ------------EKPFTVE---------------------IS 318
VN G L VQ + FT E
Sbjct: 1016 SAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAG 1075
Query: 319 PGPRIAAQI-----------GDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVR------S 361
PG A G SV+ C V G P W+ + PL+ R
Sbjct: 1076 PGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWK-KSGVPLTTGYRYKVSYNK 1134
Query: 362 EGTNSTLTLSPVSFENEHSYLCTVTCGH--------------------KKLEKGIQVELY 401
+ L +S ++ Y V H + E Q ++
Sbjct: 1135 QTGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLEEADYELLMKSQQEMLYQTQVT 1194
Query: 402 SFPRDPEI-EMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEF----LEDT 456
+F ++P++ E + G V S + ++ + + T +E+ EF E+
Sbjct: 1195 AFVQEPKVGETAPGFVY-SEYEKEYEKEQALIRKKMAKDTVVVRTYVEDQEFHISSFEER 1253
Query: 457 DMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTV 516
+K +E + ++ T +E+ G + K+ +D E E + + ++ +
Sbjct: 1254 LIKEIEYRIIKTTLEELLEEDG-----EEKMAVDISESEAVESGFDSRI------KNYRI 1302
Query: 517 LVSPSSILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGELQPL----SENATLTLIST 569
L EG V C G+P PKI W +++ +GE + A+L +
Sbjct: 1303 L--------EGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVV 1354
Query: 570 KMEDSGVYLCEGINQAGRS 588
ED G+Y N G +
Sbjct: 1355 LPEDEGIYTAFASNIKGNA 1373
Score = 47.4 bits (111), Expect = 5e-05
Identities = 33/125 (26%), Positives = 57/125 (45%), Gaps = 15/125 (12%)
Query: 233 STKLQEGGSVTMTCSSEGLPAPEIFW---SKKLDNGNLQHLSGNA---TLTLIAMRMEDS 286
+TKL G + ++C G P P+I W K+L +S + TLT++ ED
Sbjct: 30543 TTKL--GEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDE 30600
Query: 287 GIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPG----PRIAAQIGDSVMLTCSVMGCES 342
G+Y C N +G+ +L++Q P + PG + +G ++ L +G
Sbjct: 30601 GVYTCIATNEVGEVETSSKLLLQATP---QFHPGYPLKEKYYGAVGSTLRLHVMYIGRPV 30657
Query: 343 PSFSW 347
P+ +W
Sbjct: 30658 PAMTW 30662
Score = 47.0 bits (110), Expect = 6e-05
Identities = 53/220 (24%), Positives = 85/220 (38%), Gaps = 24/220 (10%)
Query: 494 FEPKQRQSTQTLYVNVAPRDTTVLVSPSSI-LEEGSSVNMTCLSQGFPAPKILWSRQ--- 549
F + +S+ TLYVN AP VL + ++ G + G P PKI W ++
Sbjct: 3220 FVAGRNRSSVTLYVN-APEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQL 3278
Query: 550 LPNG---ELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELII---QVTPKDI 603
L G + + TL LI ED+ VY CE N G + L + +V D
Sbjct: 3279 LSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQ 3338
Query: 604 KLTAFPSESV--------KEGDTVIISCTCG--NVPETWIILKKKAETGDTV-LKSIDGA 652
++ +P + EG C ++ +W KK + + +
Sbjct: 3339 EMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDT 3398
Query: 653 Y--TIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGREN 690
Y I +A +D G Y + N VG + L ++ E+
Sbjct: 3399 YQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPES 3438
Score = 47.0 bits (110), Expect = 6e-05
Identities = 45/181 (24%), Positives = 76/181 (41%), Gaps = 24/181 (13%)
Query: 527 GSSVNMTCLSQGFPAPKILWSR---QLPNGELQPLSENA---TLTLISTKMEDSGVYLCE 580
G + ++C G P P I W R +L +S + TLT+++ + ED GVY C
Sbjct: 30547 GEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCI 30606
Query: 581 GINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKE------GDTVIISCTCGNVP---ET 631
N+ G +L++Q TP+ P +KE G T+ + P T
Sbjct: 30607 ATNEVGEVETSSKLLLQATPQ-----FHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMT 30661
Query: 632 WIILKKKAETGDTVLKSIDGAYT---IRKAQLK-DAGVYECESKNKVGSQLRSLTLDVQG 687
W +K + + + YT ++ Q K AG Y+ + N G+ L +++Q
Sbjct: 30662 WFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQD 30721
Query: 688 R 688
+
Sbjct: 30722 K 30722
Score = 46.2 bits (108), Expect = 1e-04
Identities = 33/114 (28%), Positives = 56/114 (49%), Gaps = 19/114 (16%)
Query: 228 ISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSK-----KLDNG-NLQHLSGNATLTLIAM 281
++V TK++ +VT G P P+I W+K K D ++++ +T+T++
Sbjct: 13700 LTVKAGTKIELPATVT------GKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDS 13753
Query: 282 RMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTC 335
+ D+G Y+ E VN+ G+ VE+ V +K PGP A I D +C
Sbjct: 13754 KRSDTGTYIIEAVNVCGRATAVVEVNVLDK-------PGPPAAFDITDVTNESC 13800
Score = 44.7 bits (104), Expect = 3e-04
Identities = 48/209 (22%), Positives = 81/209 (38%), Gaps = 26/209 (12%)
Query: 417 NGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIED 476
+ +T S K P+V P E + T L F + D E +E+ +
Sbjct: 851 SAQKITKSVKAPTVKPS---ETRVRAEPTPLPQFPFADTPDTYKSE-AGVEVKKEVGVSI 906
Query: 477 TGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILE--------EGS 528
TG + + FE + + P + V+P +++ EG
Sbjct: 907 TGTT--------VREERFEVLHGREAKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGE 958
Query: 529 SVNMTCLSQGFPAPKILWSR---QLPNG---ELQPLSENATLTLISTKMEDSGVYLCEGI 582
SV + C G+P+P + W R Q+ + ++ S A L + EDSG + C +
Sbjct: 959 SVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTCSAV 1018
Query: 583 NQAGRSRKEVELIIQVTPKDIKLTAFPSE 611
N+AG L +QV+ + K T +E
Sbjct: 1019 NEAGTVSTSCYLAVQVSEEFEKETTAVTE 1047
Score = 44.7 bits (104), Expect = 3e-04
Identities = 41/188 (21%), Positives = 78/188 (41%), Gaps = 23/188 (12%)
Query: 523 ILEEGSSVNMTCLSQGFPAPKILWSR------QLPNGELQPLSENATLTLISTKMEDSGV 576
I++ G S+ + L QG P P++ W + + N E+ + + +L + + GV
Sbjct: 27969 IIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGV 28028
Query: 577 YLCEGINQAGRSRKEVELIIQVTP----KDIKLTAFPSESVKEGDTVIISCTCGNVPE-- 630
Y E N +G ++ E+++ +Q TP I+ T E + ++ C +
Sbjct: 28029 YTVEAKNASGSAKAEIKVKVQDTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPITHYI 28088
Query: 631 ---------TWIILKKKAETGD-TVLKSIDG-AYTIRKAQLKDAGVYECESKNKVGSQLR 679
W +++ K E T +K I+G Y R + + GV + V +Q++
Sbjct: 28089 IEKRETSRLAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQ 28148
Query: 680 SLTLDVQG 687
D G
Sbjct: 28149 YTVPDAPG 28156
Score = 44.3 bits (103), Expect = 4e-04
Identities = 51/223 (22%), Positives = 87/223 (39%), Gaps = 40/223 (17%)
Query: 403 FPRDPEIEMSGGLVNGSSVTVSCKVPSV---YPLDRLEIELLKGETILENIEFLEDTDMK 459
+P DP I++ GL+ ++V +S K P P+ +E L + E + +
Sbjct: 16010 YPPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKR 16069
Query: 460 SLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPK--QRQSTQTLYVNVAPRDTTVL 517
+E E+ F T+ED + + EF K V P D
Sbjct: 16070 DVE----ELQF--TVEDLVEG---------GEYEFRVKAVNAAGVSKPSATVGPCDCQRP 16114
Query: 518 VSPSSI-------LEEGSSVNMTCLSQGFPAPKILWSRQLPN--GELQPL---------- 558
P SI +EEG++VN+ +G P P + W + P +P+
Sbjct: 16115 DMPPSIDLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLV 16174
Query: 559 -SENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTP 600
+ TL + ++ D+G+Y +N G + KE+ L + P
Sbjct: 16175 VDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRP 16217
Score = 43.5 bits (101), Expect = 7e-04
Identities = 21/83 (25%), Positives = 43/83 (51%), Gaps = 6/83 (7%)
Query: 524 LEEGSSVNMTCLSQGFPAPKILWSR------QLPNGELQPLSENATLTLISTKMEDSGVY 577
++ G+ + + G P PKI W++ Q ++ + + +T+T++ +K D+G Y
Sbjct: 13702 VKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTY 13761
Query: 578 LCEGINQAGRSRKEVELIIQVTP 600
+ E +N GR+ VE+ + P
Sbjct: 13762 IIEAVNVCGRATAVVEVNVLDKP 13784
Score = 43.5 bits (101), Expect = 7e-04
Identities = 108/527 (20%), Positives = 189/527 (35%), Gaps = 103/527 (19%)
Query: 228 ISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW----SKKLDNG---------NLQHLSGNA 274
I + +++EG +V + +G+P P + W KK DN N +
Sbjct: 16120 IDLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTC 16179
Query: 275 TLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLT 334
TL + R D+G+Y VN +G KE+ L V + PGP + +SV
Sbjct: 16180 TLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGR-------PGPPVGPIKFESV--- 16229
Query: 335 CSVMGCESPSFSWRTQID---SPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTC---- 387
+ + SW D S ++ V + + T VS E + CT T
Sbjct: 16230 ----SADQMTLSWFPPKDDGGSKITNYVIEKREANRKTWVHVSSEPKE---CTYTIPKLL 16282
Query: 388 -GHKKLEKGIQVELYSF--PRDPEIEMSGGLVN----GSSVTVSCKVPSVYPLDRLEIEL 440
GH+ + + + Y P D E E + L + TVS + ++ E E
Sbjct: 16283 EGHEYVFRIMAQNKYGIGEPLDSEPETARNLFSVPGAPDKPTVSSVTRNSMTVNWEEPEY 16342
Query: 441 LKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQ 500
G + ++DT K + + + T+ G + + D +F
Sbjct: 16343 DGGSPVTGYWLEMKDTTSKRWKRVNRDPIKAMTL---GVSYKVTGLIEGSDYQF------ 16393
Query: 501 STQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKIL----------WSRQL 550
+ +N A V P+S+ + ++ G P PK+ WS L
Sbjct: 16394 --RVYAINAAG------VGPASLPSDPATARDPIAPPGPPFPKVTDWTKSSADLEWSPPL 16445
Query: 551 PNG-------------------ELQPLSENATLTLISTKMEDSGVYL-------CEGINQ 584
+G E E L+ T +++ Y GI +
Sbjct: 16446 KDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKLVVTGLKEGAFYKFRVRAVNIAGIGE 16505
Query: 585 AGRSRKEVELIIQVTPKDIKLTAFPSESV---KEGDTVIISCTCGNVPE--TWIILKKKA 639
G +E+ ++ D++L A + + G II+ G P TW + ++
Sbjct: 16506 PGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTL 16565
Query: 640 ETGDTV-LKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 685
T+ +I + I+ Q GVY +KN+ G + +++ +DV
Sbjct: 16566 PQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDV 16612
Score = 42.7 bits (99), Expect = 0.001
Identities = 95/476 (19%), Positives = 164/476 (34%), Gaps = 45/476 (9%)
Query: 239 GGSVTMTCSSEGLPAPEIFWSKKL------DNGNLQHLSGNATLTLIAMRMEDSGIYVCE 292
G +VT T +G P + W K D N+ A L L + SG Y C
Sbjct: 7789 GTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCI 7848
Query: 293 GVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQ-- 350
N GK L ++ V+ I + G ++L + G S +W+
Sbjct: 7849 VSNEAGKASCTTHLYIKAPAKFVKRLNDYSI--EKGKPLILEGTFTGTPPISVTWKKNGI 7906
Query: 351 -IDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEI 409
+ + + ++ L + + E+ Y C + K Q+ + P +
Sbjct: 7907 NVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQ 7966
Query: 410 EMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMT 469
+ G S ++ C++ + + KG+T L T N +
Sbjct: 7967 LEPVKVSVGDSASLQCQLAGT---PEIGVSWYKGDTKLRPTT----TYKMHFRNNVATLV 8019
Query: 470 FIPT-IEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAP--RDTTVLVSPSSILEE 526
F I D+G+ +C+A+ + ++ Q L + + RD V
Sbjct: 8020 FNQVDINDSGE-YICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETV-------- 8070
Query: 527 GSSVNMTCLSQGFPAPKILWSRQ------LPNGELQPLSENATLTLISTKMEDSGVYLCE 580
G V C G + W + PN + L ATL + T +G Y C
Sbjct: 8071 GLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCT 8130
Query: 581 GINQAGRSRKEVELIIQV--TPKDIKLTAFPSESVKEGDTVIISC-TCGNVP--ETWIIL 635
N G + LI+ P + P ++V G++ C G P +W
Sbjct: 8131 ATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVV-GESADFECHVTGTQPIKVSWAKD 8189
Query: 636 KKKAETGDTVLKSI---DGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGR 688
++ +G S T+ K D+G Y C + N+VG + L+++ R
Sbjct: 8190 SREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKER 8245
Score = 42.4 bits (98), Expect = 0.002
Identities = 62/309 (20%), Positives = 121/309 (39%), Gaps = 37/309 (11%)
Query: 307 IVQEKPFTVEISPGPRIAAQI-------GDSVMLTCSVMGCESPSFSW-RTQIDSPLSGK 358
++ ++PFT++ +P RI ++ G + +V + W ++ S K
Sbjct: 32362 VLSQQPFTLDHAP--RITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSK 32419
Query: 359 VRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGG-LVN 417
+ T+ LTL + + S C + K E L +++GG
Sbjct: 32420 IHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATL---------DVTGGDYTT 32470
Query: 418 GSSVTVSCKVP-SVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMT-FIPTIE 475
+S +VP SV+P + E + + E + ++ ++++ E + + E
Sbjct: 32471 YASQRRDEEVPRSVFP-ELTRTEAYAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYE 32529
Query: 476 DTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSI-LEEGSSVNMTC 534
+ A + A L +E ++ +T+ + +A R +L P S+ + EG S +C
Sbjct: 32530 HSASAEMKSAALEEKSLE----EKSTTRKIKTTLAAR---ILTKPRSMTVYEGESARFSC 32582
Query: 535 LSQGFPAPKILWSRQ------LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRS 588
+ G P P + W R+ ++ +T + S + D G Y N G+
Sbjct: 32583 DTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQ 32642
Query: 589 RKEVELIIQ 597
E L IQ
Sbjct: 32643 EAEFTLTIQ 32651
Score = 42.0 bits (97), Expect = 0.002
Identities = 38/166 (22%), Positives = 64/166 (38%), Gaps = 12/166 (7%)
Query: 233 STKLQEGGSVTMTCSSEGLPAPEIFW--------SKKLDNGNLQHLSGNATLTLIAMRME 284
S + EG + T G P PE+ W + L + G A LT+ A+
Sbjct: 14 SVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKA 73
Query: 285 DSGIYVCEGVNLIGKNRKEVELIVQEKPFTVE-ISPGPRIAAQIGDSVMLTCSVMGCESP 343
+SG Y + N G+ EL+V+ + + + + G V L V G +P
Sbjct: 74 NSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTP 133
Query: 344 SFSW---RTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVT 386
+ +I S L ++ EG +L ++ E+ +Y T
Sbjct: 134 VVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNAT 179
Score = 39.3 bits (90), Expect = 0.013
Identities = 52/228 (22%), Positives = 88/228 (38%), Gaps = 14/228 (6%)
Query: 209 TVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQ 268
TV + ++L+V KNTV K G + L E F K+ N NL
Sbjct: 16715 TVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKF--HKVTNDNLL 16772
Query: 269 HLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNR-----KEVELIVQEKPFTVEISPGPRI 323
+ T+ ++ D+ Y VN++G+ + K + + P T+ + ++
Sbjct: 16773 ----SRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKL 16828
Query: 324 AAQIGDSVMLTCSVMGCESPSFSW-RTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHS-Y 381
++G++ LT G P SW + + D + + T +TL L + + S
Sbjct: 16829 TIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGK 16888
Query: 382 LCTVTCGHKKLEKGI-QVELYSFPRDPEIEMSGGLVNGSSVTVSCKVP 428
C V KG QV + P P +S V + +S K P
Sbjct: 16889 YCVVVENSTGSRKGFCQVNVVDRPGPPVGPVSFDEVTKDYMVISWKPP 16936
Score = 39.3 bits (90), Expect = 0.013
Identities = 42/176 (23%), Positives = 65/176 (36%), Gaps = 18/176 (10%)
Query: 528 SSVNMTCLSQGFPAPKILWSRQ----LPNGELQPLSENA----TLTLISTKMEDSGVYLC 579
S+ + C G P P + W RQ + +G + E L + S +D+ VY
Sbjct: 30943 SNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQV 31002
Query: 580 EGINQAGRSRKEVELIIQVTPK---DIKLTAFPSESVKEGDTVIISCTCGNVPETWIILK 636
NQ G L ++V K L + G+ V I P+ I +
Sbjct: 31003 RATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQ 31062
Query: 637 KKAETGDT-------VLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDV 685
K + D V +S + KDAG Y +KN+ G +++ LDV
Sbjct: 31063 KGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDV 31118
Score = 38.9 bits (89), Expect = 0.017
Identities = 23/83 (27%), Positives = 39/83 (46%), Gaps = 8/83 (9%)
Query: 524 LEEGSSVNMTCLSQGFPAPKILWSR--------QLPNGELQPLSENATLTLISTKMEDSG 575
++EGS + M + G P P I+W + + P ++ A L + ST +DS
Sbjct: 1567 IKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSA 1626
Query: 576 VYLCEGINQAGRSRKEVELIIQV 598
Y IN+AGR ++ ++V
Sbjct: 1627 WYTATAINKAGRDTTRCKVNVEV 1649
Score = 38.9 bits (89), Expect = 0.017
Identities = 112/538 (20%), Positives = 193/538 (35%), Gaps = 89/538 (16%)
Query: 201 IDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW-- 258
+ ++ PT + V+ L V PK T ++K E +T S L A E+ W
Sbjct: 32696 VSPTETKPTPTEKVQHLPVSAPPKITQFLKAEASK--EIAKLTCVVESSVLRAKEVTWYK 32753
Query: 259 -SKKL-DNGNLQ-HLSGNAT--LTLIAMRMEDSGIYVCE----------GVNLIGK---- 299
KKL +NG+ Q H S + T L + + D G YVCE + +G+
Sbjct: 32754 DGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKS 32813
Query: 300 --------------NRKEVELIVQEK--PFTVE-ISPGPRIAAQIGDSVMLTCSVM---- 338
++K E V K P E IS P I + D+ + + SV
Sbjct: 32814 IHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAV 32873
Query: 339 ---GCESPSFSWRTQIDSPLSG---KVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKL 392
G P+ W + G K+ + L + + Y CTV +
Sbjct: 32874 KATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSV 32933
Query: 393 EKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENI-- 450
++ + + +D E + VS + S EI K + E I
Sbjct: 32934 SSSCKLTIKAI-KDTEAQK-----------VSTQKTS-------EITPQKKAVVQEEISQ 32974
Query: 451 EFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQA--KLHIDDMEFEPKQRQSTQTLYVN 508
+ L ++K E KS E + E+ K L+ + K +E + T+T +
Sbjct: 32975 KALRSEEIKMSEAKSQEKLALK--EEASKVLISEEVKKSAATSLEKSIVHEEITKTSQAS 33032
Query: 509 VAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGELQPLS---ENA 562
R + + S+ + + + A + W +L N E +
Sbjct: 33033 EEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATDVKWVLNGVELTNSEEYRYGVSGSDQ 33092
Query: 563 TLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIK--LTAFPSESVKEGDTVI 620
TLT+ D G+ C + G + + +L + D ++ S+++ EG V+
Sbjct: 33093 TLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVL 33152
Query: 621 ISCTCGNVPETWIILKKK----AETGDTVLKSIDGAYT--IRKAQLKDAGVYECESKN 672
+C P I K + + + + Y+ IR A + D+G Y ++KN
Sbjct: 33153 FTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKN 33210
Score = 37.7 bits (86), Expect = 0.039
Identities = 93/457 (20%), Positives = 164/457 (35%), Gaps = 76/457 (16%)
Query: 203 EMDSVPTVRQAVKELQVYISPKNT----VISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW 258
EM S ++++E K T +++ S + EG S +C ++G P P + W
Sbjct: 32535 EMKSAALEEKSLEEKSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTW 32594
Query: 259 SKK--LDNGNLQH----LSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKP 312
+K + + + +H +T + +++ D G Y N GK E L +Q+
Sbjct: 32595 LRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKAR 32654
Query: 313 FTVEI--------SPGPRIAAQIGDSVMLTCSVMGCE--SPSFSWRTQIDSPLSGKVRSE 362
T + SP PR+ + ++V V E P T+ + KV+
Sbjct: 32655 VTEKAVTSPPRVKSPEPRVKSP--EAVKSPKRVKSPEPSHPKAVSPTETKPTPTEKVQHL 32712
Query: 363 GTNSTLTLSPVSFENEHSYLCTVTC-----------------GHKKLEKGIQVELYSFPR 405
++ ++ + +TC G K E G YS
Sbjct: 32713 PVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADG 32772
Query: 406 DPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKS 465
E++++ L C++ +G T N++F+ KS+ K
Sbjct: 32773 TYELKIN-NLTESDQGEYVCEISG------------EGGTSKTNLQFMGQA-FKSIHEK- 32817
Query: 466 LEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAP-RDTTVLVSPSSIL 524
+ I +T K+ + + + EPK + + V V +DTTV
Sbjct: 32818 -----VSKISETKKSDQKTTESTV-TRKTEPKAPEPISSKPVIVTGLQDTTV-------- 32863
Query: 525 EEGSSVNMTCLSQGFPAPKILWSRQ---LPNGELQPLSENA---TLTLISTKMEDSGVYL 578
S + G P P +W++ + G LSE+ L + T DSG+Y
Sbjct: 32864 SSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYT 32923
Query: 579 CEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKE 615
C N AG +L I+ KD + ++ E
Sbjct: 32924 CTVKNSAGSVSSSCKLTIKAI-KDTEAQKVSTQKTSE 32959
Score = 37.4 bits (85), Expect = 0.051
Identities = 31/132 (23%), Positives = 61/132 (46%), Gaps = 16/132 (12%)
Query: 549 QLPNGELQPLSENATLTLISTKMEDSGV--YLCEGINQAGRSRKEVELIIQVTP-KDIKL 605
Q P+ E++ + +L L + +++ +G + + + R + +I + P KD+ +
Sbjct: 12148 QTPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRVKPRVIGLLRPLKDVTV 12207
Query: 606 TAFPSESVKEGDTVIISCTCG--NVPETWIILKKKAETGDTVLKSIDG---AYTIRKAQL 660
TA G+T C ++P W + KK E D V+ +G T+R +L
Sbjct: 12208 TA--------GETATFDCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKL 12259
Query: 661 KDAGVYECESKN 672
+DAG + +K+
Sbjct: 12260 EDAGEVQLTAKD 12271
Score = 37.4 bits (85), Expect = 0.051
Identities = 26/106 (24%), Positives = 45/106 (42%), Gaps = 12/106 (11%)
Query: 523 ILEEGSSVNMTCLSQGFPAPKILWSR-----QLPNGELQPLSENATLTLISTKMEDSGVY 577
I+ G + + + +G PAPK+ W + + G++ + A L + ++ +DSG Y
Sbjct: 18617 IVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKY 18676
Query: 578 LCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISC 623
+N AG V + + TP P +K D SC
Sbjct: 18677 SLTLVNPAGEKAVFVNVRVLDTPG-------PVSDLKVSDVTKTSC 18715
Score = 36.2 bits (82), Expect = 0.11
Identities = 31/103 (30%), Positives = 48/103 (46%), Gaps = 10/103 (9%)
Query: 239 GGSVTMTCSSEGLPAPEIFWSKKLD----NGNLQHLSGNATLTLI---AMRMEDSGIYVC 291
G V++ G P P I W K D NG+ Q + + +L+ + +D+G YV
Sbjct: 31042 GEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVV 31101
Query: 292 EGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLT 334
N G ++K VEL V + P + G +++ DSV LT
Sbjct: 31102 CAKNRFGIDQKTVELDVADVP---DPPRGVKVSDVSRDSVNLT 31141
Score = 35.8 bits (81), Expect = 0.15
Identities = 106/511 (20%), Positives = 179/511 (35%), Gaps = 113/511 (22%)
Query: 235 KLQEGGSVTMTCSSEGLPAPEIFWSKK---LDNGNLQHLS-----GNATLTLIAMRMEDS 286
KL EGGSV C G P P ++W K L G +S G L + +D+
Sbjct: 1092 KLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDA 1151
Query: 287 GIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFS 346
G Y N G+ L+ +E + + + + Q + + +G +P F
Sbjct: 1152 GEYTIVVRNKHGETSASASLL-EEADYELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFV 1210
Query: 347 WRT-----QIDSPLSGKVRSEGTNSTLTLSP------VSFEN----EHSYLCTVTCGHKK 391
+ + + L K ++ T T SFE E Y T +
Sbjct: 1211 YSEYEKEYEKEQALIRKKMAKDTVVVRTYVEDQEFHISSFEERLIKEIEYRIIKTTLEEL 1270
Query: 392 LEKGIQVELYSFPRDPEIEMSG--------GLVNGSSVTVSCKVPSVYPLDRLEI----- 438
LE+ + ++ + E SG ++ G VT CK+ S YPL ++
Sbjct: 1271 LEEDGEEKMAVDISESEAVESGFDSRIKNYRILEGMGVTFHCKM-SGYPLPKIAWYKDGK 1329
Query: 439 ELLKGETILENIEFLEDTDMKSL-------ENKSLEMTFIPTIEDTGKALVCQAKLHIDD 491
+ GE ++FL+D SL E++ + F I+ +C KL+++
Sbjct: 1330 RIKHGERY--QMDFLQD-GRASLRIPVVLPEDEGIYTAFASNIKGNA---ICSGKLYVEP 1383
Query: 492 ME----------FEPKQR------QSTQTLYVNVAP-----------RDTTVLVSPSSIL 524
EP R +S + ++P R + +SP L
Sbjct: 1384 AAPLGAPTYIPTLEPVSRIRSLSPRSVSRSPIRMSPARMSPARMSPARMSPARMSPGRRL 1443
Query: 525 EEGSS---------------VNMTCLSQ----------GFPAPKILW---SRQLPNGELQ 556
EE V+ CL G P P+ W +Q+ N
Sbjct: 1444 EETDESQLERLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTH 1503
Query: 557 P--LSENAT--LTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIK---LTAFP 609
+ E+ T L ++ DSG + N+AGRS V L ++ +K +
Sbjct: 1504 KVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLK 1563
Query: 610 SESVKEGDTVIISCTCGNVPETWIILKKKAE 640
+ ++KEG + + P I+ K ++
Sbjct: 1564 NVNIKEGSRLEMKVRATGNPNPDIVWLKNSD 1594
Score = 35.8 bits (81), Expect = 0.15
Identities = 33/130 (25%), Positives = 55/130 (42%), Gaps = 7/130 (5%)
Query: 306 LIVQEKPFTVEIS----PGPRIAAQIGDSVMLTCSVMGCESPSFSW-RTQIDSPLSGKVR 360
+ V+E T E+ PG ++ +IG +V L G PS SW + + S VR
Sbjct: 27552 ITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELPYKGKPKPSISWLKDGLPLKESEFVR 27611
Query: 361 SEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSF--PRDPEIEMSGGLVNG 418
T + +TLS + + EH TV + + + + + P P+ + +
Sbjct: 27612 FSKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITLGPPSKPKGPIRFDEIKA 27671
Query: 419 SSVTVSCKVP 428
SV +S VP
Sbjct: 27672 DSVILSWDVP 27681
Score = 35.8 bits (81), Expect = 0.15
Identities = 85/414 (20%), Positives = 161/414 (38%), Gaps = 39/414 (9%)
Query: 208 PTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK-LDNGN 266
P R + +L++ K TV ++ G S+ + S G P P I WSK+ +D +
Sbjct: 29437 PVERIEIPDLELADDLKKTVT-------IRAGASLRLMVSVSGRPPPVITWSKQGIDLAS 29489
Query: 267 LQHLSGNATLTLI---AMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRI 323
+ + +L+ + D+G Y E N GK V + V + P P ++
Sbjct: 29490 RAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGP---CPSVKV 29546
Query: 324 AAQIGDSVMLTCSVMGCE--SPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVS--FENEH 379
DSV +T + + +P ++ + ++ T + TL +S E
Sbjct: 29547 KEVSRDSVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTM 29606
Query: 380 SYLCTVTCG----HKKLEKGIQVELYSFPRDP-EIEMSGGLVNGSSVTVSCKVPSVYPLD 434
Y + + E V + P P ++E+ V S+VT++ + P
Sbjct: 29607 YYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVD--VTKSTVTLAWEKPLYDGGS 29664
Query: 435 RLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEF 494
RL +LE + + MK + K + T + G+ + + + +
Sbjct: 29665 RLT------GYVLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVS 29718
Query: 495 EPKQRQSTQTLY-VNVAPR-DTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILW------ 546
EP++ + T+ + V P D + + + + G V + G P P W
Sbjct: 29719 EPRETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSK 29778
Query: 547 SRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTP 600
R+ ++ ++ A LT+ T + D+G Y E N G + + +++II P
Sbjct: 29779 LRESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKP 29832
Score = 35.8 bits (81), Expect = 0.15
Identities = 20/86 (23%), Positives = 40/86 (46%), Gaps = 3/86 (3%)
Query: 323 IAAQIGDSVMLTCSVMGCESPSFSWRT---QIDSPLSGKVRSEGTNSTLTLSPVSFENEH 379
+ ++G++ L+C ++G P W ++ K+ S+G TLT+ E+E
Sbjct: 30542 VTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEG 30601
Query: 380 SYLCTVTCGHKKLEKGIQVELYSFPR 405
Y C T ++E ++ L + P+
Sbjct: 30602 VYTCIATNEVGEVETSSKLLLQATPQ 30627
Score = 35.4 bits (80), Expect = 0.19
Identities = 52/222 (23%), Positives = 80/222 (36%), Gaps = 27/222 (12%)
Query: 233 STKLQEGGSVTMTCSSEGLPAPEIFW---SKKLDNGNLQHL----SGNATLTLIAMRMED 285
S K EG + G P PE FW +++ N + G +L ++ D
Sbjct: 1465 SFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSD 1524
Query: 286 SGIYVCEGVNLIGKNRKEVELIV-----QEKPFTVEISPGPRIAAQIGDSVMLTCSVMGC 340
SG + N G++ V L V Q KP VE I + G + + G
Sbjct: 1525 SGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNI--KEGSRLEMKVRATGN 1582
Query: 341 ESPSFSWRTQIDSPLS---GKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHK------K 391
+P W D + K+R EGT L S ++ S T T +K +
Sbjct: 1583 PNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTR 1642
Query: 392 LEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPL 433
+ ++VE +PE E + G+ P + PL
Sbjct: 1643 CKVNVEVEF----AEPEPERKLIIPRGTYRAKEIAAPELEPL 1680
Score = 35.4 bits (80), Expect = 0.19
Identities = 20/83 (24%), Positives = 38/83 (45%), Gaps = 6/83 (7%)
Query: 236 LQEGGSVTMTCSSEGLPAPEIFWSK------KLDNGNLQHLSGNATLTLIAMRMEDSGIY 289
++ G S+ + +G P P + W K K N + + G+ +L + + G+Y
Sbjct: 27970 IKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVY 28029
Query: 290 VCEGVNLIGKNRKEVELIVQEKP 312
E N G + E+++ VQ+ P
Sbjct: 28030 TVEAKNASGSAKAEIKVKVQDTP 28052
Score = 35.0 bits (79), Expect = 0.25
Identities = 27/96 (28%), Positives = 44/96 (45%), Gaps = 9/96 (9%)
Query: 524 LEEGSSVNMTCLSQGFPAPKILWSRQ---LPNGELQPLSENATLTLI-STKMEDSGVYLC 579
+ G+S+ + G P P I WS+Q L + + +E+ +L ++ D+G Y
Sbjct: 29458 IRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTI 29517
Query: 580 EGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKE 615
E NQ+G+ V + + TP PS VKE
Sbjct: 29518 EAENQSGKKSATVLVKVYDTPGPC-----PSVKVKE 29548
Score = 34.7 bits (78), Expect = 0.33
Identities = 23/94 (24%), Positives = 44/94 (46%), Gaps = 6/94 (6%)
Query: 38 QIGDSVSLTCSTTGCESPFFSWRT---QIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYL 94
++G++ L+C G P W ++ K++++G T TLT+ +E Y
Sbjct: 30545 KLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYT 30604
Query: 95 CTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLE 128
C AT E ++E ++ + + P+ H PL+
Sbjct: 30605 CIATNEVGEVETSSKLLLQA---TPQFHPGYPLK 30635
Score = 34.3 bits (77), Expect = 0.43
Identities = 89/402 (22%), Positives = 148/402 (36%), Gaps = 67/402 (16%)
Query: 236 LQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYV-CEGV 294
L+ G ++ + +G P P+I WSK N NL+ G + ++ D ++ CE V
Sbjct: 19705 LRAGVTMRLYVPVKGRPPPKITWSKP--NVNLRDRIG------LDIKSTDFDTFLRCENV 19756
Query: 295 NLI--GKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQI- 351
N GK +E +K +T+ + ++ G V +T + +S +W I
Sbjct: 19757 NKYDAGKYILTLENSCGKKEYTIVV----KVLDTPGPPVNVTVKEISKDSAYVTWEPPII 19812
Query: 352 --DSPLSGKV-------RSEGTNSTLTLSPVSF-----ENEHSYLCTVTCGHKKLEKGI- 396
SP+ V R + T S SF E SY V + E GI
Sbjct: 19813 DGGSPIINYVVQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRVFAEN---EYGIG 19869
Query: 397 -------QVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILEN 449
V+ P P +++ V+ SS ++ K P R+ I
Sbjct: 19870 DPGETRDAVKASQTP-GPVVDLKVRSVSKSSCSIGWKKPHSDGGSRI---------IGYV 19919
Query: 450 IEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNV 509
++FL + + KSL + + GK + ++ E P + V
Sbjct: 19920 VDFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGEGTPSEITVVARDDVVA 19979
Query: 510 APRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGE----------LQPLS 559
D L + +E S+ + +G PAP + W + GE ++ +
Sbjct: 19980 PDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKK----GEDPLATDTRVSVESSA 20035
Query: 560 ENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPK 601
N TL + + D+G Y N AG KE + I+V K
Sbjct: 20036 VNTTLIVYDCQKSDAGKYTITLKNVAG--TKEGTISIKVVGK 20075
Score = 34.3 bits (77), Expect = 0.43
Identities = 29/113 (25%), Positives = 51/113 (45%), Gaps = 11/113 (9%)
Query: 211 RQAVKELQVYISPKNTVIS--VNP---STKLQEGGSVTMTCSSEGLPAPEIFWSKK---L 262
R + L V I K+ VI V P S +Q G + + G P P I W+K L
Sbjct: 23211 RSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPL 23270
Query: 263 DNGNLQHLSGNATLTLIAMR---MEDSGIYVCEGVNLIGKNRKEVELIVQEKP 312
+++ + LT ++++ +D G Y N++G+ +E++ +KP
Sbjct: 23271 KQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKP 23323
Score = 33.9 bits (76), Expect = 0.56
Identities = 47/199 (23%), Positives = 71/199 (35%), Gaps = 54/199 (27%)
Query: 525 EEGSSVNMTCLSQGFP-APKILWS---RQLPNGELQPLSENATLTLISTK---MEDSGVY 577
EEG V C + + + ++ W RQL N E ++ + ++ K D G Y
Sbjct: 31580 EEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTY 31639
Query: 578 LCEGINQAGRSRKEVELII-----------QVTPKDIK---------------------L 605
C+ +N G EL + + T K IK
Sbjct: 31640 RCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNK 31699
Query: 606 TAFPSESVKEGDTVIISCTCGNVPE---TWIILKKKAETGDT----VLKSIDGAY--TIR 656
TA+ E+V+ G T+ + PE TW +K + GD +S G Y TI
Sbjct: 31700 TAYVGENVRFGVTITVH------PEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTIN 31753
Query: 657 KAQLKDAGVYECESKNKVG 675
D Y ++NK G
Sbjct: 31754 SVTTDDDAEYTVVARNKYG 31772
Score = 33.9 bits (76), Expect = 0.56
Identities = 45/214 (21%), Positives = 88/214 (41%), Gaps = 33/214 (15%)
Query: 473 TIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNM 532
T++++ ++ KL I ++ Q+ STQ S I + +V
Sbjct: 32925 TVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQ---------------KTSEITPQKKAVVQ 32969
Query: 533 TCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMEDSGV------YLCEGINQAG 586
+SQ + + + + E L E A+ LIS +++ S + E I +
Sbjct: 32970 EEISQKALRSEEIKMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEITKTS 33029
Query: 587 RSRKEVELIIQVTPKDIKLTAFPSE-SVKEGDTVIISCTCGNVPET-WIILKKKAETGDT 644
++ +EV T +IK AF ++ S+ EG +++ + W++ + +
Sbjct: 33030 QASEEVR-----THAEIK--AFSTQMSINEGQRLVLKANIAGATDVKWVLNGVELTNSEE 33082
Query: 645 VLKSIDGA---YTIRKAQLKDAGVYECESKNKVG 675
+ G+ TI++A +D G+ C SK K G
Sbjct: 33083 YRYGVSGSDQTLTIKQASHRDEGILTCISKTKEG 33116
Score = 33.5 bits (75), Expect = 0.73
Identities = 20/99 (20%), Positives = 47/99 (47%), Gaps = 13/99 (13%)
Query: 524 LEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKM-------EDSGV 576
++ G ++ ++ + +G P PK+ W ++ + P +T + +K+ ED G+
Sbjct: 17230 IKVGDTLRLSAIIKGVPFPKVTWKKEDRDA---PTKARIDVTPVGSKLEIRNAAHEDGGI 17286
Query: 577 YLCEGINQAGRSRKEVELII---QVTPKDIKLTAFPSES 612
Y N AG V++++ P+D++++ +S
Sbjct: 17287 YSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDS 17325
Score = 33.5 bits (75), Expect = 0.73
Identities = 42/174 (24%), Positives = 64/174 (36%), Gaps = 26/174 (14%)
Query: 236 LQEGGSVTMTCSSEGLPAPEIFWSK-----KLDNGNLQHLSGN-ATLTLIAMRMEDSGIY 289
++ G +V + + G P P + W K K G + N TL L ++ +DSG Y
Sbjct: 19307 VKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDY 19366
Query: 290 VCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRT 349
N G ++L V +K PGP + +I + M + SW
Sbjct: 19367 TITAENSSGSKSATIKLKVLDK-------PGPPASVKI--------NKMYSDRAMLSWEP 19411
Query: 350 QIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSF 403
++ SE TN + S N TV +EK I+ Y F
Sbjct: 19412 PLEDG-----GSEITNYIVDKRETSRPNWAQVSATVPITSCSVEKLIEGHEYQF 19460
Score = 32.3 bits (72), Expect = 1.6
Identities = 88/437 (20%), Positives = 162/437 (37%), Gaps = 50/437 (11%)
Query: 191 KVLVCRA-KLHIDEMDSVPTVRQAVKELQVYISPKNTVIS-VNPSTKLQEGGSVTMTCSS 248
K+ VC K+ + E SVP + +L+ +P+ + S + ++ GGS +
Sbjct: 23992 KIRVCALNKVGLGEATSVPGTVKPEDKLE---APELDLDSELRKGIVVRAGGSARIHIPF 24048
Query: 249 EGLPAPEIFWSKK----LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV 304
+G P PEI WS++ D ++ L++ D+G Y+ + N G V
Sbjct: 24049 KGRPTPEITWSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSKSAFV 24108
Query: 305 ELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGK---VRS 361
+ V + P P +A + V + + E P ++ + + K R
Sbjct: 24109 TVKVLDTP-----GPPQNLAVK---EVRKDSAFLVWEPPIIDGGAKVKNYVIDKRESTRK 24160
Query: 362 EGTNSTLTLSPVSFENEHSYLCTV----TCGHKKLEKGIQVELYSFPRDPEIEMSGGLVN 417
N + S SF+ E+ + + G+ VE + E G V
Sbjct: 24161 AYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVT 24220
Query: 418 GSSVT-VSCKVPSVYPLDRLEIELLKGETILENIEFLE--DTDMKSLENKSLEMTFIPTI 474
+ V+ S + P E G +L + ++ T+ S+ +S + T
Sbjct: 24221 LTDVSQTSASLMWEKP------EHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTG 24274
Query: 475 EDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTV-----LVSPSSILEEGSS 529
+G+ + K + K + + L V V +D T+ L + ++ G
Sbjct: 24275 LSSGQEYQFRVK------AYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGED 24328
Query: 530 VNMTCLSQGFPAPKILWSRQ---LPNGELQPLSENATLTLISTK---MEDSGVYLCEGIN 583
+ + G P P I W + L + E AT T++ K +D G Y N
Sbjct: 24329 LKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATN 24388
Query: 584 QAGRSRKEVELIIQVTP 600
AG + + + +I+ P
Sbjct: 24389 SAGTATENLSVIVLEKP 24405
Score = 32.3 bits (72), Expect = 1.6
Identities = 19/61 (31%), Positives = 31/61 (50%), Gaps = 8/61 (13%)
Query: 523 ILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQ------PLSENATLTLISTKMEDSGV 576
I++ G+S MT +G P P +LWS+ P+ +L+ +LT+ + DSG
Sbjct: 26197 IVKAGASFTMTVPFRGRPVPNVLWSK--PDTDLRTRAYVDTTDSRTSLTIENANRNDSGK 26254
Query: 577 Y 577
Y
Sbjct: 26255 Y 26255
Score = 32.3 bits (72), Expect = 1.6
Identities = 86/426 (20%), Positives = 137/426 (32%), Gaps = 59/426 (13%)
Query: 221 ISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK---LDNGNLQHLS---GNA 274
IS K +++ T + + G P P W+K + G LS G
Sbjct: 32848 ISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGF 32907
Query: 275 TLTLIAMRMEDSGIYVCEGVNLIG----------KNRKEVELIVQEKPFTVEISPGPRIA 324
L + DSG+Y C N G K K+ E T EI+P +
Sbjct: 32908 FLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKKAV 32967
Query: 325 AQ--IGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYL 382
Q I + + + E+ S + + E S T S +E
Sbjct: 32968 VQEEISQKALRSEEIKMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEE--- 33024
Query: 383 CTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLK 442
E E+ +F I LV +++ + V V +EL
Sbjct: 33025 -ITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATDVKWVLN----GVELTN 33079
Query: 443 GETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALV-CQAKLHIDDMEFEPKQRQS 501
E + + T + + + + I T + +V CQ L
Sbjct: 33080 SEEYRYGVSGSDQT-LTIKQASHRDEGILTCISKTKEGIVKCQYDL-------------- 33124
Query: 502 TQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILW-SRQLP-----NGEL 555
TL ++ + S + EG +V TC G P+P+I W LP N +
Sbjct: 33125 --TLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSI 33182
Query: 556 QPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESV-- 613
+L + + + DSG Y + N G+ L++ + L PS V
Sbjct: 33183 SRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMV------LPLVEEPSREVVL 33236
Query: 614 -KEGDT 618
GDT
Sbjct: 33237 RTSGDT 33242
Score = 32.0 bits (71), Expect = 2.1
Identities = 27/100 (27%), Positives = 45/100 (45%), Gaps = 7/100 (7%)
Query: 596 IQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWIILKKKAETG---DTVLKSI 649
I VTP + ++ + +V EG++V + C P TW + E+ +S
Sbjct: 938 IPVTPPTL-VSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSG 996
Query: 650 DGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRE 689
IR+A +D+G + C + N+ G+ S L VQ E
Sbjct: 997 IARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSE 1036
Score = 32.0 bits (71), Expect = 2.1
Identities = 23/84 (27%), Positives = 37/84 (44%), Gaps = 7/84 (8%)
Query: 611 ESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLK----SIDGAYTIRKAQLKDAGVY 666
+ +K GDT+ +S VP + KK+ T + + IR A +D G+Y
Sbjct: 17228 QHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIY 17287
Query: 667 ECESKNKVGSQ---LRSLTLDVQG 687
+N GS+ ++ L LD G
Sbjct: 17288 SLTVENPAGSKTVSVKVLVLDKPG 17311
Score = 32.0 bits (71), Expect = 2.1
Identities = 34/141 (24%), Positives = 59/141 (41%), Gaps = 21/141 (14%)
Query: 527 GSSVNMTCLSQGFPAPKILWSRQLP----NGELQPLSENATLTLI---STKMEDSGVYLC 579
G V++ G P P I W + NG Q + + +L+ + +D+G Y+
Sbjct: 31042 GEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVV 31101
Query: 580 EGINQAGRSRKEVELIIQVT---PKDIKLTAFPSESV--------KEGDTVI---ISCTC 625
N+ G +K VEL + P+ +K++ +SV +G + I I C
Sbjct: 31102 CAKNRFGIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKC 31161
Query: 626 GNVPETWIILKKKAETGDTVL 646
E W+ + + ET TV+
Sbjct: 31162 ATTAERWLRVGQARETRYTVI 31182
Score = 31.6 bits (70), Expect = 2.8
Identities = 29/124 (23%), Positives = 52/124 (41%), Gaps = 21/124 (16%)
Query: 504 TLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSR-----QLPNGELQPL 558
T+ + ++ R T+ V + G V++ G P PKI WS+ + P LQ
Sbjct: 15396 TIKLRLSVRGDTIKV------KAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQIT 15449
Query: 559 SENATLTLISTKM-------EDSGVYLCEGINQAGRSRKEVELII---QVTPKDIKLTAF 608
E + + T++ ED G Y N+ G + V + + P+++ +T
Sbjct: 15450 KEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFRNVHVEVYDRPSPPRNLAVTDI 15509
Query: 609 PSES 612
+ES
Sbjct: 15510 KAES 15513
Score = 31.6 bits (70), Expect = 2.8
Identities = 24/98 (24%), Positives = 39/98 (39%), Gaps = 13/98 (13%)
Query: 228 ISVNPST-KLQEGGSVTMTCSSEGLPAPEIFWSK------------KLDNGNLQHLSGNA 274
+SV T K++ G V + GLP P+I WSK ++ +
Sbjct: 15401 LSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKT 15460
Query: 275 TLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKP 312
L++ ED G Y N +G + V + V ++P
Sbjct: 15461 ELSIPKAVREDKGTYTVTASNRLGSVFRNVHVEVYDRP 15498
Score = 31.6 bits (70), Expect = 2.8
Identities = 20/69 (28%), Positives = 31/69 (44%), Gaps = 6/69 (8%)
Query: 250 GLPAPEIFWSK------KLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKE 303
G P P + W K + N + N+ LT+ ED G YV + N G+ +
Sbjct: 22173 GRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAGEAIET 22232
Query: 304 VELIVQEKP 312
+ +IV +KP
Sbjct: 22233 LNVIVLDKP 22241
Score = 31.2 bits (69), Expect = 3.6
Identities = 17/68 (25%), Positives = 31/68 (45%), Gaps = 4/68 (5%)
Query: 523 ILEEGSSVNMTCLSQGFPAPKILWSRQLPN----GELQPLSENATLTLISTKMEDSGVYL 578
++ G+S+ + QG P P +WS+ N ++ +TLT+ + D+G Y
Sbjct: 28368 VVRAGASIRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVENCNRNDAGKYT 28427
Query: 579 CEGINQAG 586
N +G
Sbjct: 28428 LTVENNSG 28435
Score = 30.8 bits (68), Expect = 4.7
Identities = 20/98 (20%), Positives = 43/98 (43%), Gaps = 6/98 (6%)
Query: 221 ISPKNTVISVNPSTK--LQEGGSVTMTCSSEGLPAPEIFWSKK----LDNGNLQHLSGNA 274
+ P ++ N + + ++ G ++ ++ +G+P P++ W K+ + +
Sbjct: 17213 LEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGS 17272
Query: 275 TLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKP 312
L + ED GIY N G V+++V +KP
Sbjct: 17273 KLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKP 17310
Score = 30.8 bits (68), Expect = 4.7
Identities = 33/158 (20%), Positives = 63/158 (39%), Gaps = 13/158 (8%)
Query: 513 DTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWS------RQLPNGELQPLSENATLTL 566
D T + + + GS + G PAPK+ W ++ + + TLT+
Sbjct: 28648 DLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTV 28707
Query: 567 ISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISC--- 623
+ DSG Y N AG V +++ P + T S ++ ++S
Sbjct: 28708 KDSMRGDSGRYFLTLENTAGVKTFSVTVVVIGRPGPV--TGPIEVSSVSAESCVLSWGEP 28765
Query: 624 TCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLK 661
G E + +K E+G T + ++ ++++ Q+K
Sbjct: 28766 KDGGGTEITNYIVEKRESGTTAWQLVNS--SVKRTQIK 28801
Score = 30.4 bits (67), Expect = 6.2
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 3/65 (4%)
Query: 40 GDSVSLTCSTTGCESPFFSWRT---QIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCT 96
G+SV+L C +G SP +W QI+S ++ ++T + + L + + + C+
Sbjct: 957 GESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTCS 1016
Query: 97 ATCES 101
A E+
Sbjct: 1017 AVNEA 1021
Score = 30.4 bits (67), Expect = 6.2
Identities = 34/153 (22%), Positives = 56/153 (36%), Gaps = 28/153 (18%)
Query: 236 LQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQH--------LSGNATLTLIAMRMEDSG 287
++ G ++ + G P PE+ W+K D +L + ++ +L + D G
Sbjct: 18213 VKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGG 18272
Query: 288 IYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVM--------G 339
YV N G + V +K PGP +I D C+V G
Sbjct: 18273 KYVVTATNTAGSFVAYATVNVLDK-------PGPVRNLKIVDVSSDRCTVCWDPPEDDGG 18325
Query: 340 CESPSF-----SWRTQIDSPLSGKVRSEGTNST 367
CE ++ + + S S V + GT T
Sbjct: 18326 CEIQNYILEKCETKRMVWSTYSATVLTPGTTVT 18358
Score = 30.4 bits (67), Expect = 6.2
Identities = 24/83 (28%), Positives = 41/83 (49%), Gaps = 8/83 (9%)
Query: 236 LQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQ---HLSGNATLTLIAM---RMEDSGIY 289
++ G S+ + +G PAPE+ W+K DN NL+ ++ + TL+ + D+G +
Sbjct: 20788 VRAGLSIRIFVPIKGRPAPEVTWTK--DNINLKNRANIENTESFTLLIIPECNRYDTGKF 20845
Query: 290 VCEGVNLIGKNRKEVELIVQEKP 312
V N GK V + V + P
Sbjct: 20846 VMTIENPAGKKSGFVNVRVLDTP 20868
Score = 30.4 bits (67), Expect = 6.2
Identities = 19/68 (27%), Positives = 31/68 (45%), Gaps = 4/68 (5%)
Query: 249 EGLPAPEIFWSK----KLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV 304
+G PAPE+ W++ LD +++ S L + + DSG Y+ N G V
Sbjct: 21885 KGRPAPEVKWARDHGESLDKASIESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFV 21944
Query: 305 ELIVQEKP 312
+ V + P
Sbjct: 21945 NVRVLDTP 21952
Score = 30.4 bits (67), Expect = 6.2
Identities = 30/101 (29%), Positives = 38/101 (37%), Gaps = 9/101 (8%)
Query: 605 LTAFPSESVKEGDTVIISCTCGNVPE---TWI----ILKKKAETGDTVLKSIDGAYTIRK 657
LT S +V EG++ SC P TW+ +L A T K + I
Sbjct: 32564 LTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTK-YKSTFEISS 32622
Query: 658 AQLKDAGVYECESKNKVGSQLRSLTLDVQ-GRENNKDYFSP 697
Q D G Y +N G Q TL +Q R K SP
Sbjct: 32623 VQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSP 32663
Score = 30.0 bits (66), Expect = 8.1
Identities = 25/101 (24%), Positives = 48/101 (47%), Gaps = 5/101 (4%)
Query: 523 ILEEGSSVNMTCLSQGFPAPKILWSR---QLPNGELQPLSENATLTLI-STKMEDSGVYL 578
++ G S+ + +G PAP++ W++ L N +E+ TL +I D+G ++
Sbjct: 20787 VVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFV 20846
Query: 579 CEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTV 619
N AG+ V + + TP + L P++ K+ T+
Sbjct: 20847 MTIENPAGKKSGFVNVRVLDTPGPV-LNLRPTDITKDSVTL 20886
Score = 30.0 bits (66), Expect = 8.1
Identities = 24/90 (26%), Positives = 37/90 (41%), Gaps = 11/90 (12%)
Query: 236 LQEGGSVTMTCSSEGLPAPEIFWSKK----LDNGNLQHLSGNATLTLIAMRMEDSGIYVC 291
++ G S TMT G P P + WSK + +LT+ DSG Y
Sbjct: 26198 VKAGASFTMTVPFRGRPVPNVLWSKPDTDLRTRAYVDTTDSRTSLTIENANRNDSGKYTL 26257
Query: 292 EGVNLIGKNRKEVELIVQEKPFTVEISPGP 321
N++ + + L+V+ V +PGP
Sbjct: 26258 TIQNVL--SAASLTLVVK-----VLDTPGP 26280
Score = 30.0 bits (66), Expect = 8.1
Identities = 23/84 (27%), Positives = 35/84 (41%), Gaps = 6/84 (7%)
Query: 235 KLQEGGSVTMTCSSEGLPAPEIFW---SKKLDNGNLQHLSGNATLTLIAMRMED---SGI 288
K + G SV + G PAP I W K+L L + L I ++ D SG
Sbjct: 26883 KYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGC 26942
Query: 289 YVCEGVNLIGKNRKEVELIVQEKP 312
Y + N +G + + + +KP
Sbjct: 26943 YELKLRNAMGSASATIRVQILDKP 26966
Score = 30.0 bits (66), Expect = 8.1
Identities = 27/111 (24%), Positives = 44/111 (39%), Gaps = 22/111 (19%)
Query: 504 TLYVNVAPRDTTVLVSPSSIL-----EEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPL 558
T+ ++ P D+T+ +L +EG SV G P P + W + + QPL
Sbjct: 31781 TVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEK-----DGQPL 31835
Query: 559 SENATLTLI------------STKMEDSGVYLCEGINQAGRSRKEVELIIQ 597
S + +I T ED+G Y N AG + + L ++
Sbjct: 31836 SLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQVE 31886
>gi|157168355 CD22 molecule [Homo sapiens]
Length = 847
Score = 100 bits (250), Expect = 4e-21
Identities = 154/670 (22%), Positives = 265/670 (39%), Gaps = 96/670 (14%)
Query: 64 DSPLNGKVTNE----------GTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIY 113
+S +GKV +E TL+++PV + ++ K + I + +
Sbjct: 78 ESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVS 137
Query: 114 SFPKDPEIHLSGPLEAGKPITVKCSVA-DVYPFDRLEIDLLKGDHLMKSQEFLEDADRKS 172
P P I L ++ + +T+ C + Y + LL+G + ++ KS
Sbjct: 138 ERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKS 197
Query: 173 LETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVK---ELQVYISPKNTVIS 229
+ T+S E+ F+P GK++ C+ + + S TV+ VK +L++ ++P + ++
Sbjct: 198 VFTRS-ELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIV- 255
Query: 230 VNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIY 289
+EG SVTMTC PE L +G TL L + + SG Y
Sbjct: 256 -------REGDSVTMTCEVSS-SNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKY 307
Query: 290 VCEGVNLIGKNR-KEVELIVQ--EKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESP-SF 345
C+ N +G R +EV L VQ +P TV+I P + G V C + P ++
Sbjct: 308 CCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVE---GSQVEFLCMSLANPLPTNY 364
Query: 346 SWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTV--TCGHKKLEKGIQVELYSF 403
+W +GK T + + + + +Y C G + G ++++
Sbjct: 365 TWYH------NGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYP 418
Query: 404 PR--DPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSL 461
P+ I+ + G +VT+SC S P ++ E +
Sbjct: 419 PKKVTTVIQNPMPIREGDTVTLSCNYNSSNP----------------SVTRYEWKPHGAW 462
Query: 462 ENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTV-LVSP 520
E SL + I + + C A S L V APRD V + P
Sbjct: 463 EEPSLGVLKIQNVGWDNTTIACAACNSWCSW-------ASPVALNVQYAPRDVRVRKIKP 515
Query: 521 SSILEEGSSVNMTC-LSQGFPAP-KILWSRQLPNGELQPLSENATLTLISTKMEDSGVYL 578
S + G+SV++ C S P + W + NG L L + + L S ED+G Y
Sbjct: 516 LSEIHSGNSVSLQCDFSSSHPKEVQFFWEK---NGRL--LGKESQLNFDSISPEDAGSYS 570
Query: 579 CEGINQAGR-SRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE----TWI 633
C N G+ + K L + P+ ++++ P + V EG + ++C P TW
Sbjct: 571 CWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWF 630
Query: 634 ILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVG---SQLRSLTLDVQGREN 690
+ + L + +++ +G Y C+ N VG S L +LT+
Sbjct: 631 ------DWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTV------- 677
Query: 691 NKDYFSPELL 700
Y+SPE +
Sbjct: 678 ---YYSPETI 684
Score = 64.3 bits (155), Expect = 4e-10
Identities = 81/389 (20%), Positives = 154/389 (39%), Gaps = 51/389 (13%)
Query: 26 KIETTPESRYLAQIGDSVSLTCSTTGCESPF--FSWRTQIDSPLNGKVTNEGTTSTLTMN 83
K+ T ++ + GD+V+L+C+ + W+ E + L +
Sbjct: 421 KVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPH-------GAWEEPSLGVLKIQ 473
Query: 84 PVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLE---AGKPITVKCSVA 140
V + N + C A + + + P+D + PL +G ++++C +
Sbjct: 474 NVGWDNT-TIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFS 532
Query: 141 DVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLH 200
+P K +F + + + L +S ++ F + + C
Sbjct: 533 SSHP---------------KEVQFFWEKNGRLLGKES-QLNFDSISPEDAGSYSCWVN-- 574
Query: 201 IDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSK 260
+S+ L+V +P+ +S++P ++ EG S T+TC S+ P +
Sbjct: 575 ----NSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWF 630
Query: 261 KLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVE-LIVQEKPFTVEISP 319
+N +L + S L L ++++ SG Y C+G N +GK R + L V P T+
Sbjct: 631 DWNNQSLPYHS--QKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETI---- 684
Query: 320 GPRIAAQIGDSV-MLTCSVMGCESPSFSWRTQIDSPLSGKVRSEG---TNSTLTLSPVSF 375
G R+A +G + +L ++ G + RTQ L + N + +P+S
Sbjct: 685 GRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQGLQENSSGQSFFVRNKKVRRAPLS- 743
Query: 376 ENEHSYLCTVTCGHKKLEKGIQVELYSFP 404
E HS + C + +E GI FP
Sbjct: 744 EGPHS----LGCYNPMMEDGISYTTLRFP 768
>gi|189571583 intercellular adhesion molecule 5 precursor [Homo
sapiens]
Length = 924
Score = 95.9 bits (237), Expect = 1e-19
Identities = 163/723 (22%), Positives = 260/723 (35%), Gaps = 103/723 (14%)
Query: 36 LAQIGDSVSLTCSTTGCESPFFSWRTQI---DSPLNGKVTNEG----TTSTLTMNPVSFG 88
L ++G ++C+ G P R + D L+ VT EG T+T T + G
Sbjct: 238 LLEVGSERPVSCTLDGL-FPASEARVYLALGDQNLSPDVTLEGDAFVATATATASAEQEG 296
Query: 89 NEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGP-LEAGKPITVKCSVADVYPFDR 147
+C T E V IYSFP P + LS P + G+ +TV C+
Sbjct: 297 -ARQLVCNVTLGGENRETRENVTIYSFPA-PLLTLSEPSVSEGQMVTVTCAA-------- 346
Query: 148 LEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSV 207
G + + E + A + + ++ D + C A L ++D
Sbjct: 347 -------GAQALVTLEGVPAA----VPGQPAQLQLNATENDDRRSFFCDATL---DVDGE 392
Query: 208 PTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNL 267
++ EL+V +P+ S EG T+ C + G P P + ++ D G +
Sbjct: 393 TLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARS-DGGAV 451
Query: 268 QHLS--GNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAA 325
L G T L SG Y C+ N G+ K+V L V+ P + RI
Sbjct: 452 LALGLLGPVTRAL-------SGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITW 504
Query: 326 QIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLT-LSPVSFENEHSYLCT 384
G L+C G P VRS + + L V+ E+ +Y C
Sbjct: 505 LEGTEASLSCVAHGVPPPDVIC-----------VRSGELGAVIEGLLRVAREHAGTYRCE 553
Query: 385 VTCGHKKLEKGIQVELYSFPR--DPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLK 442
T K + V + PR +P + V GS SC+V + ++ +
Sbjct: 554 ATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGK---PQPSVKCVG 610
Query: 443 GETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQST 502
E + S + P I VC A +
Sbjct: 611 SGGATEGVLLPLAPPDPSPRAPRIPRVLAPGI------YVCNAT---------NRHGSVA 655
Query: 503 QTLYVNVAP---RDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQ-LPNGELQPL 558
+T+ V+ D + S + LE + + C ++G P+P + SR+ +P E Q +
Sbjct: 656 KTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQQRV 715
Query: 559 SENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDT 618
S ED+G Y C N G + V + ++ P +L A P V+ G
Sbjct: 716 SR-----------EDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGN 764
Query: 619 VIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQL 678
++C P I + + L S + ++ A G YEC + N G
Sbjct: 765 FTLTCRAEAWPPAQISWRAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHA 824
Query: 679 RSLTLDVQGRENNKDYFSPELLVLY----FASSLIIPAIGMIIYFARKANMKGSYSLVEA 734
R +T+ V G P L V ++L+ G+ Y A KG Y++ EA
Sbjct: 825 RRITVRVAG---------PWLWVAVGGAAGGAALLAAGAGLAFYVQSTACKKGEYNVQEA 875
Query: 735 QKS 737
+ S
Sbjct: 876 ESS 878
Score = 75.1 bits (183), Expect = 2e-13
Identities = 94/390 (24%), Positives = 152/390 (38%), Gaps = 59/390 (15%)
Query: 314 TVEISP-GPRIAA----QIGDSVMLTCSVMGCESPSFSWRTQI---DSPLSGKVRSEGTN 365
T +SP PR+AA ++G ++C++ G P+ R + D LS V EG
Sbjct: 223 TFSLSPDAPRLAAPRLLEVGSERPVSCTLDGL-FPASEARVYLALGDQNLSPDVTLEGDA 281
Query: 366 STLTLSPVSF---ENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVN-GSSV 421
T + + E +C VT G + E V +YSFP P + +S V+ G V
Sbjct: 282 FVATATATASAEQEGARQLVCNVTLGGENRETRENVTIYSFPA-PLLTLSEPSVSEGQMV 340
Query: 422 TVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKAL 481
TV+C G L +E + ++ + ++ T D ++
Sbjct: 341 TVTCAA---------------GAQALVTLEGVP----AAVPGQPAQLQLNATENDDRRSF 381
Query: 482 VCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPA 541
C A L +D + + LY APR S EG + C ++G P
Sbjct: 382 FCDATLDVDGETLIKNRSAELRVLY---APRLDDSDCPRSWTWPEGPEQTLRCEARGNPE 438
Query: 542 PKILWSRQ-----LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELII 596
P + +R L G L P++ SG Y C+ N G + K+V L +
Sbjct: 439 PSVHCARSDGGAVLALGLLGPVTRAL-----------SGTYRCKAANDQGEAVKDVTLTV 487
Query: 597 QVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIR 656
+ P + + EG +SC VP +I + E G I+G +
Sbjct: 488 EYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGAV----IEGLLRVA 543
Query: 657 KAQLKDAGVYECESKNKVGSQLRSLTLDVQ 686
+ + AG Y CE+ N GS +++ + V+
Sbjct: 544 R---EHAGTYRCEATNPRGSAAKNVAVTVE 570
Score = 52.8 bits (125), Expect = 1e-06
Identities = 88/369 (23%), Positives = 144/369 (39%), Gaps = 64/369 (17%)
Query: 287 GIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIA-AQIGDSVMLTCSVMGCESPSF 345
G++ G+ L G + V ++PF ++ P R+A + G S+ L CS C P
Sbjct: 14 GLWAALGLGLFGLSA------VSQEPFWADLQP--RVAFVERGGSLWLNCST-NCPRPE- 63
Query: 346 SWRTQIDSPLSGKVRSEGTNSTLTLSPVSF----ENEHSYLCTVTCGHKKLEKGIQVELY 401
L +R GT L E E +C C + L+ + +
Sbjct: 64 ------RGGLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFRCARRTLQARGLIRTF 117
Query: 402 SFPRDPEI-EMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKS 460
P E+ + G + T+SC+VP P L + LL+G L F +
Sbjct: 118 QRPDRVELMPLPPWQPVGENFTLSCRVPGAGPRASLTLTLLRGAQELIRRSFAGEP--PR 175
Query: 461 LENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVN-VAPRD-TTVLV 518
L T + ED G C+A+L + R L+ N APR+ T +
Sbjct: 176 ARGAVLTATVLARREDHGANFSCRAELDL---------RPHGLGLFENSSAPRELRTFSL 226
Query: 519 SPSS-------ILEEGSSVNMTCLSQG-FPAPK-----ILWSRQL-PNGELQPLSENATL 564
SP + +LE GS ++C G FPA + L + L P+ L+ + AT
Sbjct: 227 SPDAPRLAAPRLLEVGSERPVSCTLDGLFPASEARVYLALGDQNLSPDVTLEGDAFVATA 286
Query: 565 TLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPS-------ESVKEGD 617
T ++ ++ L + G +R+ T +++ + +FP+ SV EG
Sbjct: 287 TATASAEQEGARQLVCNVTLGGENRE--------TRENVTIYSFPAPLLTLSEPSVSEGQ 338
Query: 618 TVIISCTCG 626
V ++C G
Sbjct: 339 MVTVTCAAG 347
Score = 39.3 bits (90), Expect = 0.013
Identities = 120/598 (20%), Positives = 205/598 (34%), Gaps = 105/598 (17%)
Query: 116 PKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLET 175
P P + LE G V C++ ++P + L GD + LE +
Sbjct: 228 PDAPRLAAPRLLEVGSERPVSCTLDGLFPASEARVYLALGDQNLSPDVTLEG------DA 281
Query: 176 KSLEVTFTPVIEDIG-KVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPST 234
T T E G + LVC L + R+ + + +Y P + PS
Sbjct: 282 FVATATATASAEQEGARQLVCNVTLGGEN-------RETRENVTIYSFPAPLLTLSEPS- 333
Query: 235 KLQEGGSVTMTCSS--------EGLPA-----PEIFWSKKLDNGNLQHLSGNATLTLIAM 281
+ EG VT+TC++ EG+PA P +N + + +ATL +
Sbjct: 334 -VSEGQMVTVTCAAGAQALVTLEGVPAAVPGQPAQLQLNATENDDRRSFFCDATLDV--- 389
Query: 282 RMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRI-AAQIGDSVMLTCSVMGC 340
+G LI KNR EL V P ++ S PR G L C G
Sbjct: 390 ----------DGETLI-KNR-SAELRVLYAP-RLDDSDCPRSWTWPEGPEQTLRCEARGN 436
Query: 341 ESPSFSWRTQIDSPLSGKVRSEG--TNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQV 398
PS RS+G + L PV+ +Y C + K + +
Sbjct: 437 PEPSVHC-----------ARSDGGAVLALGLLGPVTRALSGTYRCKAANDQGEAVKDVTL 485
Query: 399 ELYSFPRDPEIEMSGGL--VNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDT 456
+ P + + + G+ ++SC V P D + + + ++E +
Sbjct: 486 TVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGAVIEGL------ 539
Query: 457 DMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPK-QRQSTQTLYVNVAPRDTT 515
+ + C+A P+ + V PR
Sbjct: 540 --------------LRVAREHAGTYRCEAT--------NPRGSAAKNVAVTVEYGPRFEE 577
Query: 516 VLVSPSSILEEGSSVNMTCLSQGFPAP--KILWSRQLPNGELQPLS--ENATLTLISTKM 571
+ EGS +C G P P K + S G L PL+ + + ++
Sbjct: 578 PSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRV 637
Query: 572 EDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEG-DTVIISCTCGNVPE 630
G+Y+C N+ G K V + + P+ + T ++ EG + ++C P
Sbjct: 638 LAPGIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPS 697
Query: 631 TWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGR 688
+ ++ ++ +DAG Y C + N G+ R++T+ V+ R
Sbjct: 698 PGVRCSREGIPWPEQ----------QRVSREDAGTYHCVATNAHGTDSRTVTVGVEYR 745
>gi|33519481 neural cell adhesion molecule 2 precursor [Homo
sapiens]
Length = 837
Score = 90.9 bits (224), Expect = 4e-18
Identities = 97/395 (24%), Positives = 165/395 (41%), Gaps = 55/395 (13%)
Query: 322 RIAAQIGDSVMLTCSVMGCESPSFSWRT----QIDSPLSGKVRSEGTNSTLTLSPVSFEN 377
++ +G+S TC+ +G E S W +I S V+ EG S LT+ + E+
Sbjct: 29 KVELSVGESKFFTCTAIG-EPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIED 87
Query: 378 EHSYLCTVTCGHKKLEKG-IQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRL 436
Y C T + ++ + +E+Y E+ G V C+V S
Sbjct: 88 AGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSS------ 141
Query: 437 EIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHI-DDMEFE 495
+ E + + D L N +L++ I ++ C+ ++ +++F
Sbjct: 142 PAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEG--IYRCEGRVEARGEIDFR 199
Query: 496 PKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGEL 555
+ VNV P + S ++ E G + +C + G P P I W R NG+L
Sbjct: 200 DI------IVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFR---NGKL 250
Query: 556 QPLSE-------NATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAF 608
+E N LT+ + D G Y+C N+AG K+ L + V P I+L
Sbjct: 251 IEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLK-- 308
Query: 609 PSESVKEGDTVIISCTCGN--VPE-TWIILKKKAETGDTVL---KSIDG----------- 651
+E+ E V + C +PE TW K+A G T KS+DG
Sbjct: 309 -NETTYENGQVTLVCDAEGEPIPEITW----KRAVDGFTFTEGDKSLDGRIEVKGQHGSS 363
Query: 652 AYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 686
+ I+ +L D+G Y+CE+ +++G +S+ LD++
Sbjct: 364 SLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIE 398
Score = 77.0 bits (188), Expect = 6e-14
Identities = 86/374 (22%), Positives = 157/374 (41%), Gaps = 51/374 (13%)
Query: 40 GDSVSLTCSTTGCESPFFSW---RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCT 96
G+ + C + +P SW ++ + + + + +N ++ +E Y C
Sbjct: 129 GEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILN-INKSDEGIYRCE 187
Query: 97 ATCESR-KLEKGIQVEIYSFPKD---PEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDL 152
E+R +++ + I + P P+ + E G+ +T C A P +
Sbjct: 188 GRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCR-ASGSPEPAIS--- 243
Query: 153 LKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQ 212
++ + +E+ ++ L+ + E+T +I G VCRA E + +Q
Sbjct: 244 -----WFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDE-----KQ 293
Query: 213 AVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLD--------- 263
A LQV++ P +I + T E G VT+ C +EG P PEI W + +D
Sbjct: 294 AF--LQVFVQPH--IIQLKNETTY-ENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDK 348
Query: 264 --NGNL----QHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEI 317
+G + QH G+++L + +++ DSG Y CE + IG ++K + L ++ P I
Sbjct: 349 SLDGRIEVKGQH--GSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAP--KFI 404
Query: 318 SPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQ-----IDSPLSGKVRSEGTNSTLTLSP 372
S + G+ + ++C V S WR + + K S G L ++P
Sbjct: 405 SNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAP 464
Query: 373 VSFENEHSYLCTVT 386
S + Y CT T
Sbjct: 465 TSDNDFGRYNCTAT 478
Score = 71.6 bits (174), Expect = 2e-12
Identities = 108/502 (21%), Positives = 200/502 (39%), Gaps = 67/502 (13%)
Query: 217 LQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW----SKKLDNGN---LQH 269
LQV IS +SV G S TC++ G P I W +K+ + +Q
Sbjct: 21 LQVTISLSKVELSV--------GESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQK 71
Query: 270 LSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGD 329
+ LT+ +ED+GIY C+ + G+ ++ ++ + T P+ Q G+
Sbjct: 72 EGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQ-GE 130
Query: 330 SVMLTCSVMGCESPSFSW--RTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTC 387
+ C V +P+ SW + + +S + N+ L + ++ +E Y C
Sbjct: 131 DAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRV 190
Query: 388 GHK-KLEKGIQVELYSFPRD---PEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKG 443
+ +++ + + + P P+ + G +T SC+ S P +
Sbjct: 191 EARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRA-SGSPEPAI------- 242
Query: 444 ETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQ 503
+ N + +E+ + L+ + E+T I G VC+A K + +
Sbjct: 243 -SWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRAT---------NKAGEDEK 292
Query: 504 TLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLP-----------N 552
++ V + + + + E G V + C ++G P P+I W R + +
Sbjct: 293 QAFLQVFVQPHIIQLKNETTYENGQ-VTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLD 351
Query: 553 GELQPLSEN--ATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDI-KLTAFP 609
G ++ ++ ++L + K+ DSG Y CE ++ G +K + L I+ PK I T +
Sbjct: 352 GRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYY 411
Query: 610 SESVKEGDTVIISCTCGNVPET---W----IILKKKAETG-DTVLKSIDGAYTIRKAQLK 661
S EG+ + ISC + P W ++L K T T I
Sbjct: 412 S---WEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDN 468
Query: 662 DAGVYECESKNKVGSQLRSLTL 683
D G Y C + N +G++ + L
Sbjct: 469 DFGRYNCTATNHIGTRFQEYIL 490
Score = 70.5 bits (171), Expect = 5e-12
Identities = 93/438 (21%), Positives = 167/438 (38%), Gaps = 36/438 (8%)
Query: 14 ILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRT----QIDSPLNG 69
+L ++ ++ QA T S+ +G+S TC+ G E W +I S
Sbjct: 9 LLGLLVSSGQALLQVTISLSKVELSVGESKFFTCTAIG-EPESIDWYNPQGEKIISTQRV 67
Query: 70 KVTNEGTTSTLTMNPVSFGNEHSYLCTAT-CESRKLEKGIQVEIYSFPKDPEIHLSGPLE 128
V EG S LT+ + + Y C AT + + E + +EIY E+ +
Sbjct: 68 VVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFK 127
Query: 129 AGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIED 188
G+ V C V+ P + + S +L+ ++ + +
Sbjct: 128 QGEDAEVVCRVSS-SPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRC 186
Query: 189 IGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSS 248
G+V A+ ID D + V + P ++ + + + G +T +C +
Sbjct: 187 EGRV---EARGEIDFRDIIVIVN---------VPPAISMPQKSFNATAERGEEMTFSCRA 234
Query: 249 EGLPAPEIFWSK--KLDNGNLQHL--SGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV 304
G P P I W + KL N +++ N LT+ + D G YVC N G++ K+
Sbjct: 235 SGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQA 294
Query: 305 ELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWR--------TQIDSPLS 356
L V +P +++ V L C G P +W+ T+ D L
Sbjct: 295 FLQVFVQPHIIQLK---NETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLD 351
Query: 357 GKVRSEGT--NSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGG 414
G++ +G +S+L + V + Y C +K + +++ P+ +
Sbjct: 352 GRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYY 411
Query: 415 LVNGSSVTVSCKVPSVYP 432
G+ + +SC V S P
Sbjct: 412 SWEGNPINISCDVKSNPP 429
>gi|11225258 myelin associated glycoprotein isoform a precursor
[Homo sapiens]
Length = 626
Score = 86.7 bits (213), Expect = 7e-17
Identities = 95/366 (25%), Positives = 152/366 (41%), Gaps = 31/366 (8%)
Query: 345 FSWRTQI-DSPLSGKVRSEGT----NSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVE 399
F RTQ+ G+ R G N TL LS VS E Y G +
Sbjct: 74 FKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSEHS 133
Query: 400 LYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMK 459
+ P I + +V G+ V VSC VP P R E+ L E + E + +
Sbjct: 134 VLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDE 193
Query: 460 SLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVS 519
+ + F+PT E G L CQA ++FE Y ++ + V+V
Sbjct: 194 GTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEG---------YASMDVKYPPVIVE 244
Query: 520 PSSILE--EGSSVNMTCLSQGFPAPKILWSRQLPNGEL--QPLSENATLTLISTKMEDSG 575
+S +E EGS V++ C + P P + W R +G + + ++E+ L L + G
Sbjct: 245 MNSSVEAIEGSHVSLLCGADSNPPPLLTWMR---DGTVLREAVAESLLLELEEVTPAEDG 301
Query: 576 VYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIIL 635
VY C N G+ + V L + P K T + EG+TV I C+ + P+ + +
Sbjct: 302 VYACLAENAYGQDNRTVGLSVMYAPW--KPTVNGTMVAVEGETVSILCSTQSNPDPILTI 359
Query: 636 KKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYF 695
K+ + TV+ + + +D G Y C ++N+ G + + L V+ F
Sbjct: 360 FKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE--------F 411
Query: 696 SPELLV 701
+P LL+
Sbjct: 412 APVLLL 417
Score = 51.6 bits (122), Expect = 3e-06
Identities = 51/227 (22%), Positives = 93/227 (40%), Gaps = 14/227 (6%)
Query: 119 PEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSL 178
P I + + AG + V C V D P R E+ L + L + + + +
Sbjct: 141 PNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVS 200
Query: 179 EVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQE 238
+ F P E G L C+A + VK V ++ +N S + E
Sbjct: 201 LLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPV-------IVEMNSSVEAIE 253
Query: 239 GGSVTMTCSSEGLPAPEIFWSKKLDNGNL--QHLSGNATLTLIAMRMEDSGIYVCEGVNL 296
G V++ C ++ P P + W + +G + + ++ + L L + + G+Y C N
Sbjct: 254 GSHVSLLCGADSNPPPLLTWMR---DGTVLREAVAESLLLELEEVTPAEDGVYACLAENA 310
Query: 297 IGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESP 343
G++ + V L V P+ ++ G +A + G++V + CS P
Sbjct: 311 YGQDNRTVGLSVMYAPWKPTVN-GTMVAVE-GETVSILCSTQSNPDP 355
Score = 34.7 bits (78), Expect = 0.33
Identities = 31/119 (26%), Positives = 48/119 (40%), Gaps = 4/119 (3%)
Query: 229 SVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGI 288
+VN + EG +V++ CS++ P P + K+ + L L A+ ED G
Sbjct: 330 TVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGE 389
Query: 289 YVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSW 347
Y C N G+ L V+ P + S A D+V C V PS ++
Sbjct: 390 YWCVAENQYGQRATAFNLSVEFAPVLLLESH----CAAARDTVQCLCVVKSNPEPSVAF 444
>gi|18104957 myelin associated glycoprotein isoform b precursor
[Homo sapiens]
Length = 582
Score = 86.7 bits (213), Expect = 7e-17
Identities = 95/366 (25%), Positives = 152/366 (41%), Gaps = 31/366 (8%)
Query: 345 FSWRTQI-DSPLSGKVRSEGT----NSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVE 399
F RTQ+ G+ R G N TL LS VS E Y G +
Sbjct: 74 FKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSEHS 133
Query: 400 LYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMK 459
+ P I + +V G+ V VSC VP P R E+ L E + E + +
Sbjct: 134 VLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDE 193
Query: 460 SLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVS 519
+ + F+PT E G L CQA ++FE Y ++ + V+V
Sbjct: 194 GTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEG---------YASMDVKYPPVIVE 244
Query: 520 PSSILE--EGSSVNMTCLSQGFPAPKILWSRQLPNGEL--QPLSENATLTLISTKMEDSG 575
+S +E EGS V++ C + P P + W R +G + + ++E+ L L + G
Sbjct: 245 MNSSVEAIEGSHVSLLCGADSNPPPLLTWMR---DGTVLREAVAESLLLELEEVTPAEDG 301
Query: 576 VYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIIL 635
VY C N G+ + V L + P K T + EG+TV I C+ + P+ + +
Sbjct: 302 VYACLAENAYGQDNRTVGLSVMYAPW--KPTVNGTMVAVEGETVSILCSTQSNPDPILTI 359
Query: 636 KKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYF 695
K+ + TV+ + + +D G Y C ++N+ G + + L V+ F
Sbjct: 360 FKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVE--------F 411
Query: 696 SPELLV 701
+P LL+
Sbjct: 412 APVLLL 417
Score = 51.6 bits (122), Expect = 3e-06
Identities = 51/227 (22%), Positives = 93/227 (40%), Gaps = 14/227 (6%)
Query: 119 PEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSL 178
P I + + AG + V C V D P R E+ L + L + + + +
Sbjct: 141 PNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVS 200
Query: 179 EVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQE 238
+ F P E G L C+A + VK V ++ +N S + E
Sbjct: 201 LLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPV-------IVEMNSSVEAIE 253
Query: 239 GGSVTMTCSSEGLPAPEIFWSKKLDNGNL--QHLSGNATLTLIAMRMEDSGIYVCEGVNL 296
G V++ C ++ P P + W + +G + + ++ + L L + + G+Y C N
Sbjct: 254 GSHVSLLCGADSNPPPLLTWMR---DGTVLREAVAESLLLELEEVTPAEDGVYACLAENA 310
Query: 297 IGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESP 343
G++ + V L V P+ ++ G +A + G++V + CS P
Sbjct: 311 YGQDNRTVGLSVMYAPWKPTVN-GTMVAVE-GETVSILCSTQSNPDP 355
Score = 34.7 bits (78), Expect = 0.33
Identities = 31/119 (26%), Positives = 48/119 (40%), Gaps = 4/119 (3%)
Query: 229 SVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGI 288
+VN + EG +V++ CS++ P P + K+ + L L A+ ED G
Sbjct: 330 TVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGE 389
Query: 289 YVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSW 347
Y C N G+ L V+ P + S A D+V C V PS ++
Sbjct: 390 YWCVAENQYGQRATAFNLSVEFAPVLLLESH----CAAARDTVQCLCVVKSNPEPSVAF 444
>gi|54607031 immunoglobulin superfamily, member 4D [Homo sapiens]
Length = 437
Score = 85.1 bits (209), Expect = 2e-16
Identities = 71/246 (28%), Positives = 119/246 (48%), Gaps = 22/246 (8%)
Query: 79 TLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIH-LSGPLEAGKPITVKC 137
+++++ VS +E Y C+ K K + + P+ P+I S P+ G + + C
Sbjct: 90 SISVSDVSLSDEGQYTCSLFTMPVKTSKAY-LTVLGVPEKPQISGFSSPVMEGDLMQLTC 148
Query: 138 SVADVYPFDRLEIDLLKGDHLMKSQEFL--EDADRKSLETKSLEVTFTPVIEDIGKVLVC 195
+ P +I K D +K ++L EDA+RK+ T S + F D G ++C
Sbjct: 149 KTSGSKP--AADIRWFKNDKEIKDVKYLKEEDANRKTF-TVSSTLDFRVDRSDDGVAVIC 205
Query: 196 RAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKL-QEGGSVTMTCSSEGLPAP 254
R +D T + A++ L+++ +P +I PST QEG + +TC S+G P P
Sbjct: 206 R----VDHESLNATPQVAMQVLEIHYTPSVKII---PSTPFPQEGQPLILTCESKGKPLP 258
Query: 255 E-IFWSKKLDNGNL----QHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQ 309
E + W+K D G L + + L ++ + D+G Y CE N IG++ E LIV
Sbjct: 259 EPVLWTK--DGGELPDPDRMVVSGRELNILFLNKTDNGTYRCEATNTIGQSSAEYVLIVH 316
Query: 310 EKPFTV 315
+ P T+
Sbjct: 317 DVPNTL 322
Score = 78.2 bits (191), Expect = 3e-14
Identities = 74/316 (23%), Positives = 137/316 (43%), Gaps = 34/316 (10%)
Query: 328 GDSVMLTCSVMGCESPSFSWRTQIDSPLSGK------------VRSEGTNSTLTLSPVSF 375
G + +LTC V ++ S W L VR+ ++++S VS
Sbjct: 39 GGTAILTCRVDQNDNTSLQWSNPAQQTLYFDDKKALRDNRIELVRASWHELSISVSDVSL 98
Query: 376 ENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIE-MSGGLVNGSSVTVSCKVPSVYPLD 434
+E Y C++ K K L P P+I S ++ G + ++CK P
Sbjct: 99 SDEGQYTCSLFTMPVKTSKAYLTVL-GVPEKPQISGFSSPVMEGDLMQLTCKTSGSKPA- 156
Query: 435 RLEIELLKGETILENIEFLEDTDM-KSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDME 493
+I K + ++++++L++ D + S + F D G A++C+ +D
Sbjct: 157 -ADIRWFKNDKEIKDVKYLKEEDANRKTFTVSSTLDFRVDRSDDGVAVICR----VDHES 211
Query: 494 FEPKQRQSTQTLYVNVAPRDTTVLVSPSSIL-EEGSSVNMTCLSQGFPAPK-ILWSR--- 548
+ + Q L ++ P +V + PS+ +EG + +TC S+G P P+ +LW++
Sbjct: 212 LNATPQVAMQVLEIHYTP---SVKIIPSTPFPQEGQPLILTCESKGKPLPEPVLWTKDGG 268
Query: 549 QLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAF 608
+LP+ + +S L ++ D+G Y CE N G+S E LI+ D+ T
Sbjct: 269 ELPDPDRMVVS-GRELNILFLNKTDNGTYRCEATNTIGQSSAEYVLIVH----DVPNTLL 323
Query: 609 PSESVKEGDTVIISCT 624
P+ + T ++ T
Sbjct: 324 PTTIIPSLTTATVTTT 339
Score = 37.7 bits (86), Expect = 0.039
Identities = 51/193 (26%), Positives = 77/193 (39%), Gaps = 30/193 (15%)
Query: 521 SSILEEGSSVNMTCLSQGF-PAPKILWSRQLPNGELQPL-------SENATLTLIST--- 569
SS + EG + +TC + G PA I W + + E++ + + T T+ ST
Sbjct: 135 SSPVMEGDLMQLTCKTSGSKPAADIRWFKN--DKEIKDVKYLKEEDANRKTFTVSSTLDF 192
Query: 570 ---KMEDSGVYLC----EGINQAGRSRKEVELIIQVTP--KDIKLTAFPSESVKEGDTVI 620
+ +D +C E +N + +V L I TP K I T FP +EG +I
Sbjct: 193 RVDRSDDGVAVICRVDHESLNATPQVAMQV-LEIHYTPSVKIIPSTPFP----QEGQPLI 247
Query: 621 ISCTCGN--VPETWIILKKKAETGDTVLKSIDGA-YTIRKAQLKDAGVYECESKNKVGSQ 677
++C +PE + K E D + G I D G Y CE+ N +G
Sbjct: 248 LTCESKGKPLPEPVLWTKDGGELPDPDRMVVSGRELNILFLNKTDNGTYRCEATNTIGQS 307
Query: 678 LRSLTLDVQGREN 690
L V N
Sbjct: 308 SAEYVLIVHDVPN 320
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 84.3 bits (207), Expect = 4e-16
Identities = 113/493 (22%), Positives = 193/493 (39%), Gaps = 67/493 (13%)
Query: 236 LQEGGSVTMTCSSEGLPAPEIFWSK--------KLDNGNLQHLSGNATLTLIAM-----R 282
+ +G T+ C +EG P P I W K K D + + L + +L + +
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKS 99
Query: 283 MEDSGIYVCEGVNLIGK---NRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSV-M 338
D G+YVC N +G+ + +E+ + F S + +G+ ++ C
Sbjct: 100 RPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD---VMVAVGEPAVMECQPPR 156
Query: 339 GCESPSFSWRTQIDSPLSGK---VRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKG 395
G P+ SW+ SPL K + G +T + S ++ + T G ++ E
Sbjct: 157 GHPEPTISWKKD-GSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVA 215
Query: 396 --IQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFL 453
+E SF + P + + S C+ P+ + GE E
Sbjct: 216 ELTVLERPSFVKRPS---NLAVTVDDSAEFKCEARGD-PVPTVRWRKDDGELPKSRYEIR 271
Query: 454 EDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRD 513
+D +K + T D G + C A+ + E ++ TL V V
Sbjct: 272 DDHTLKIRK---------VTAGDMG-SYTCVAENMVGKAE-------ASATLTVQVGSEP 314
Query: 514 TTVLVSP-SSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGEL---QP--------LSEN 561
+V P ++ G +V C + G P P I W R+ L QP +S+
Sbjct: 315 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 374
Query: 562 ATLTLISTKMEDSGVYLCEGINQAG----RSRKEVELIIQVTPKDIKLTAFPSESVKEGD 617
LT+ + + D G Y+C+ +N AG ++ EV +I P + +++V
Sbjct: 375 GDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG 434
Query: 618 TVIISCTCGNVPETWIILKKK---AETGDTVLKSID-GAYTIRKAQLKDAGVYECESKNK 673
T ++SC P I+ +K T D+ +K ++ G IR A+L D G Y C +
Sbjct: 435 TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP 494
Query: 674 VGSQLRSLTLDVQ 686
G S ++VQ
Sbjct: 495 SGEATWSAYIEVQ 507
Score = 69.3 bits (168), Expect = 1e-11
Identities = 124/541 (22%), Positives = 213/541 (39%), Gaps = 74/541 (13%)
Query: 91 HSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEA-GKPITVKCSVADVYPFDRLE 149
H YL C L G ++ FP H S + + G+P T+ C A+ P +E
Sbjct: 7 HFYLFGLIC----LCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCK-AEGRPTPTIE 61
Query: 150 IDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIE------DIGKVLVCRAKLHIDE 203
KG +++ + + R L + SL F ++ D G V VC A+ ++ E
Sbjct: 62 --WYKGGERVETDKDDPRSHRMLLPSGSL--FFLRIVHGRKSRPDEG-VYVCVARNYLGE 116
Query: 204 MDSV-PTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSS-EGLPAPEIFWSKK 261
S ++ A+ +P + +++V G M C G P P I W K
Sbjct: 117 AVSHNASLEVAILRDDFRQNPSDVMVAV--------GEPAVMECQPPRGHPEPTISWKKD 168
Query: 262 ---LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV-ELIVQEKPFTVEI 317
LD+ + + L + R D+G YVC G N++G+ EV EL V E+P V+
Sbjct: 169 GSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVK- 227
Query: 318 SPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFEN 377
+A + DS C G P+ WR D L + TL + V+ +
Sbjct: 228 -RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD-DGELPKSRYEIRDDHTLKIRKVTAGD 285
Query: 378 EHSYLCTV--TCGHKKLEKGIQVELYSFPRDPEIEMSGGLVN-GSSVTVSCKV-----PS 429
SY C G + + V++ S P ++ +V G +VT C+ P+
Sbjct: 286 MGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPA 345
Query: 430 VYPLDRLEIELL-----KGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQ 484
++ LL + ++ D + +++ + T+ G +++ +
Sbjct: 346 IFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAG-SIITK 404
Query: 485 AKLHIDDMEFE---PKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPA 541
A L + D+ + P RQ P + TV V + +L +C++ G P
Sbjct: 405 AYLEVTDVIADRPPPVIRQ---------GPVNQTVAVDGTFVL--------SCVATGSPV 447
Query: 542 PKILWSR-----QLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELII 596
P ILW + + ++ L EN L + K+ D+G Y C +G + + +
Sbjct: 448 PTILWRKDGVLVSTQDSRIKQL-ENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 506
Query: 597 Q 597
Q
Sbjct: 507 Q 507
Score = 50.4 bits (119), Expect = 6e-06
Identities = 87/406 (21%), Positives = 155/406 (38%), Gaps = 59/406 (14%)
Query: 33 SRYLAQIGDSVSLTCSTT-GCESPFFSWRTQIDSPLNGK---VTNEGTTSTLTMNPVSFG 88
S + +G+ + C G P SW+ SPL+ K +T G +T S
Sbjct: 138 SDVMVAVGEPAVMECQPPRGHPEPTISWKKD-GSPLDDKDERITIRGGKLMITYTRKSDA 196
Query: 89 NEHSYLCTATCESRKLEKGIQ----VEIYSFPKDPEIHLSGPLEAGKPITVKCSV-ADVY 143
+ Y+C T + E + +E SF K P + + KC D
Sbjct: 197 GK--YVCVGTNMVGERESEVAELTVLERPSFVKRPS---NLAVTVDDSAEFKCEARGDPV 251
Query: 144 PFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEV-TFTPVIED-IGKVLVCRAKLHI 201
P R D G+ E +D K + + ++ ++T V E+ +GK
Sbjct: 252 PTVRWRKD--DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA--------- 300
Query: 202 DEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK 261
E + TV+ + + P++ V+++ G +VT C + G P P IFW ++
Sbjct: 301 -EASATLTVQVGSEPPHFVVKPRDQVVAL--------GRTVTFQCEATGNPQPAIFWRRE 351
Query: 262 -----------LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIG----KNRKEVEL 306
+ + +S LT+ ++ D G Y+C+ +N+ G K EV
Sbjct: 352 GSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTD 411
Query: 307 IVQEKPFTVEISPGP-RIAAQIGDSVMLTCSVMGCESPSFSWRTQ--IDSPLSGKVRSEG 363
++ ++P V I GP + + +L+C G P+ WR + S +++ +
Sbjct: 412 VIADRPPPV-IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIK-QL 469
Query: 364 TNSTLTLSPVSFENEHSYLC--TVTCGHKKLEKGIQVELYSFPRDP 407
N L + + Y C + G I+V+ + P P
Sbjct: 470 ENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQP 515
Score = 37.0 bits (84), Expect = 0.066
Identities = 46/183 (25%), Positives = 68/183 (37%), Gaps = 24/183 (13%)
Query: 523 ILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGELQPLSENATLTLIS----------T 569
I+ +G + C ++G P P I W ++ + P S L S
Sbjct: 39 IVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRK 98
Query: 570 KMEDSGVYLCEGINQAGRS-RKEVELIIQVTPKDIKLTAFPSE-SVKEGDTVIISC-TCG 626
D GVY+C N G + L + + D + PS+ V G+ ++ C
Sbjct: 99 SRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN--PSDVMVAVGEPAVMECQPPR 156
Query: 627 NVPETWIILKKKAETGDTVLKSI---DGAYTIRKAQLKDAGVYECESKNKVG---SQLRS 680
PE I KK D + I G I + DAG Y C N VG S++
Sbjct: 157 GHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAE 216
Query: 681 LTL 683
LT+
Sbjct: 217 LTV 219
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 84.3 bits (207), Expect = 4e-16
Identities = 113/493 (22%), Positives = 193/493 (39%), Gaps = 67/493 (13%)
Query: 236 LQEGGSVTMTCSSEGLPAPEIFWSK--------KLDNGNLQHLSGNATLTLIAM-----R 282
+ +G T+ C +EG P P I W K K D + + L + +L + +
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKS 99
Query: 283 MEDSGIYVCEGVNLIGK---NRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSV-M 338
D G+YVC N +G+ + +E+ + F S + +G+ ++ C
Sbjct: 100 RPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD---VMVAVGEPAVMECQPPR 156
Query: 339 GCESPSFSWRTQIDSPLSGK---VRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKG 395
G P+ SW+ SPL K + G +T + S ++ + T G ++ E
Sbjct: 157 GHPEPTISWKKD-GSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVA 215
Query: 396 --IQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFL 453
+E SF + P + + S C+ P+ + GE E
Sbjct: 216 ELTVLERPSFVKRPS---NLAVTVDDSAEFKCEARGD-PVPTVRWRKDDGELPKSRYEIR 271
Query: 454 EDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRD 513
+D +K + T D G + C A+ + E ++ TL V V
Sbjct: 272 DDHTLKIRK---------VTAGDMG-SYTCVAENMVGKAE-------ASATLTVQVGSEP 314
Query: 514 TTVLVSP-SSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGEL---QP--------LSEN 561
+V P ++ G +V C + G P P I W R+ L QP +S+
Sbjct: 315 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 374
Query: 562 ATLTLISTKMEDSGVYLCEGINQAG----RSRKEVELIIQVTPKDIKLTAFPSESVKEGD 617
LT+ + + D G Y+C+ +N AG ++ EV +I P + +++V
Sbjct: 375 GDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG 434
Query: 618 TVIISCTCGNVPETWIILKKK---AETGDTVLKSID-GAYTIRKAQLKDAGVYECESKNK 673
T ++SC P I+ +K T D+ +K ++ G IR A+L D G Y C +
Sbjct: 435 TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP 494
Query: 674 VGSQLRSLTLDVQ 686
G S ++VQ
Sbjct: 495 SGEATWSAYIEVQ 507
Score = 69.3 bits (168), Expect = 1e-11
Identities = 124/541 (22%), Positives = 213/541 (39%), Gaps = 74/541 (13%)
Query: 91 HSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEA-GKPITVKCSVADVYPFDRLE 149
H YL C L G ++ FP H S + + G+P T+ C A+ P +E
Sbjct: 7 HFYLFGLIC----LCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCK-AEGRPTPTIE 61
Query: 150 IDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIE------DIGKVLVCRAKLHIDE 203
KG +++ + + R L + SL F ++ D G V VC A+ ++ E
Sbjct: 62 --WYKGGERVETDKDDPRSHRMLLPSGSL--FFLRIVHGRKSRPDEG-VYVCVARNYLGE 116
Query: 204 MDSV-PTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSS-EGLPAPEIFWSKK 261
S ++ A+ +P + +++V G M C G P P I W K
Sbjct: 117 AVSHNASLEVAILRDDFRQNPSDVMVAV--------GEPAVMECQPPRGHPEPTISWKKD 168
Query: 262 ---LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV-ELIVQEKPFTVEI 317
LD+ + + L + R D+G YVC G N++G+ EV EL V E+P V+
Sbjct: 169 GSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVK- 227
Query: 318 SPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFEN 377
+A + DS C G P+ WR D L + TL + V+ +
Sbjct: 228 -RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD-DGELPKSRYEIRDDHTLKIRKVTAGD 285
Query: 378 EHSYLCTV--TCGHKKLEKGIQVELYSFPRDPEIEMSGGLVN-GSSVTVSCKV-----PS 429
SY C G + + V++ S P ++ +V G +VT C+ P+
Sbjct: 286 MGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPA 345
Query: 430 VYPLDRLEIELL-----KGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQ 484
++ LL + ++ D + +++ + T+ G +++ +
Sbjct: 346 IFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAG-SIITK 404
Query: 485 AKLHIDDMEFE---PKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPA 541
A L + D+ + P RQ P + TV V + +L +C++ G P
Sbjct: 405 AYLEVTDVIADRPPPVIRQ---------GPVNQTVAVDGTFVL--------SCVATGSPV 447
Query: 542 PKILWSR-----QLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELII 596
P ILW + + ++ L EN L + K+ D+G Y C +G + + +
Sbjct: 448 PTILWRKDGVLVSTQDSRIKQL-ENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 506
Query: 597 Q 597
Q
Sbjct: 507 Q 507
Score = 50.4 bits (119), Expect = 6e-06
Identities = 87/406 (21%), Positives = 155/406 (38%), Gaps = 59/406 (14%)
Query: 33 SRYLAQIGDSVSLTCSTT-GCESPFFSWRTQIDSPLNGK---VTNEGTTSTLTMNPVSFG 88
S + +G+ + C G P SW+ SPL+ K +T G +T S
Sbjct: 138 SDVMVAVGEPAVMECQPPRGHPEPTISWKKD-GSPLDDKDERITIRGGKLMITYTRKSDA 196
Query: 89 NEHSYLCTATCESRKLEKGIQ----VEIYSFPKDPEIHLSGPLEAGKPITVKCSV-ADVY 143
+ Y+C T + E + +E SF K P + + KC D
Sbjct: 197 GK--YVCVGTNMVGERESEVAELTVLERPSFVKRPS---NLAVTVDDSAEFKCEARGDPV 251
Query: 144 PFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEV-TFTPVIED-IGKVLVCRAKLHI 201
P R D G+ E +D K + + ++ ++T V E+ +GK
Sbjct: 252 PTVRWRKD--DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA--------- 300
Query: 202 DEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK 261
E + TV+ + + P++ V+++ G +VT C + G P P IFW ++
Sbjct: 301 -EASATLTVQVGSEPPHFVVKPRDQVVAL--------GRTVTFQCEATGNPQPAIFWRRE 351
Query: 262 -----------LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIG----KNRKEVEL 306
+ + +S LT+ ++ D G Y+C+ +N+ G K EV
Sbjct: 352 GSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTD 411
Query: 307 IVQEKPFTVEISPGP-RIAAQIGDSVMLTCSVMGCESPSFSWRTQ--IDSPLSGKVRSEG 363
++ ++P V I GP + + +L+C G P+ WR + S +++ +
Sbjct: 412 VIADRPPPV-IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIK-QL 469
Query: 364 TNSTLTLSPVSFENEHSYLC--TVTCGHKKLEKGIQVELYSFPRDP 407
N L + + Y C + G I+V+ + P P
Sbjct: 470 ENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQP 515
Score = 37.0 bits (84), Expect = 0.066
Identities = 46/183 (25%), Positives = 68/183 (37%), Gaps = 24/183 (13%)
Query: 523 ILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGELQPLSENATLTLIS----------T 569
I+ +G + C ++G P P I W ++ + P S L S
Sbjct: 39 IVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRK 98
Query: 570 KMEDSGVYLCEGINQAGRS-RKEVELIIQVTPKDIKLTAFPSE-SVKEGDTVIISC-TCG 626
D GVY+C N G + L + + D + PS+ V G+ ++ C
Sbjct: 99 SRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN--PSDVMVAVGEPAVMECQPPR 156
Query: 627 NVPETWIILKKKAETGDTVLKSI---DGAYTIRKAQLKDAGVYECESKNKVG---SQLRS 680
PE I KK D + I G I + DAG Y C N VG S++
Sbjct: 157 GHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAE 216
Query: 681 LTL 683
LT+
Sbjct: 217 LTV 219
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 84.3 bits (207), Expect = 4e-16
Identities = 113/493 (22%), Positives = 193/493 (39%), Gaps = 67/493 (13%)
Query: 236 LQEGGSVTMTCSSEGLPAPEIFWSK--------KLDNGNLQHLSGNATLTLIAM-----R 282
+ +G T+ C +EG P P I W K K D + + L + +L + +
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKS 99
Query: 283 MEDSGIYVCEGVNLIGK---NRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSV-M 338
D G+YVC N +G+ + +E+ + F S + +G+ ++ C
Sbjct: 100 RPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD---VMVAVGEPAVMECQPPR 156
Query: 339 GCESPSFSWRTQIDSPLSGK---VRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKG 395
G P+ SW+ SPL K + G +T + S ++ + T G ++ E
Sbjct: 157 GHPEPTISWKKD-GSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVA 215
Query: 396 --IQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFL 453
+E SF + P + + S C+ P+ + GE E
Sbjct: 216 ELTVLERPSFVKRPS---NLAVTVDDSAEFKCEARGD-PVPTVRWRKDDGELPKSRYEIR 271
Query: 454 EDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRD 513
+D +K + T D G + C A+ + E ++ TL V V
Sbjct: 272 DDHTLKIRK---------VTAGDMG-SYTCVAENMVGKAE-------ASATLTVQVGSEP 314
Query: 514 TTVLVSP-SSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGEL---QP--------LSEN 561
+V P ++ G +V C + G P P I W R+ L QP +S+
Sbjct: 315 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 374
Query: 562 ATLTLISTKMEDSGVYLCEGINQAG----RSRKEVELIIQVTPKDIKLTAFPSESVKEGD 617
LT+ + + D G Y+C+ +N AG ++ EV +I P + +++V
Sbjct: 375 GDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG 434
Query: 618 TVIISCTCGNVPETWIILKKK---AETGDTVLKSID-GAYTIRKAQLKDAGVYECESKNK 673
T ++SC P I+ +K T D+ +K ++ G IR A+L D G Y C +
Sbjct: 435 TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP 494
Query: 674 VGSQLRSLTLDVQ 686
G S ++VQ
Sbjct: 495 SGEATWSAYIEVQ 507
Score = 69.3 bits (168), Expect = 1e-11
Identities = 124/541 (22%), Positives = 213/541 (39%), Gaps = 74/541 (13%)
Query: 91 HSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEA-GKPITVKCSVADVYPFDRLE 149
H YL C L G ++ FP H S + + G+P T+ C A+ P +E
Sbjct: 7 HFYLFGLIC----LCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCK-AEGRPTPTIE 61
Query: 150 IDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIE------DIGKVLVCRAKLHIDE 203
KG +++ + + R L + SL F ++ D G V VC A+ ++ E
Sbjct: 62 --WYKGGERVETDKDDPRSHRMLLPSGSL--FFLRIVHGRKSRPDEG-VYVCVARNYLGE 116
Query: 204 MDSV-PTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSS-EGLPAPEIFWSKK 261
S ++ A+ +P + +++V G M C G P P I W K
Sbjct: 117 AVSHNASLEVAILRDDFRQNPSDVMVAV--------GEPAVMECQPPRGHPEPTISWKKD 168
Query: 262 ---LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV-ELIVQEKPFTVEI 317
LD+ + + L + R D+G YVC G N++G+ EV EL V E+P V+
Sbjct: 169 GSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVK- 227
Query: 318 SPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFEN 377
+A + DS C G P+ WR D L + TL + V+ +
Sbjct: 228 -RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD-DGELPKSRYEIRDDHTLKIRKVTAGD 285
Query: 378 EHSYLCTV--TCGHKKLEKGIQVELYSFPRDPEIEMSGGLVN-GSSVTVSCKV-----PS 429
SY C G + + V++ S P ++ +V G +VT C+ P+
Sbjct: 286 MGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPA 345
Query: 430 VYPLDRLEIELL-----KGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQ 484
++ LL + ++ D + +++ + T+ G +++ +
Sbjct: 346 IFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAG-SIITK 404
Query: 485 AKLHIDDMEFE---PKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPA 541
A L + D+ + P RQ P + TV V + +L +C++ G P
Sbjct: 405 AYLEVTDVIADRPPPVIRQ---------GPVNQTVAVDGTFVL--------SCVATGSPV 447
Query: 542 PKILWSR-----QLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELII 596
P ILW + + ++ L EN L + K+ D+G Y C +G + + +
Sbjct: 448 PTILWRKDGVLVSTQDSRIKQL-ENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 506
Query: 597 Q 597
Q
Sbjct: 507 Q 507
Score = 50.4 bits (119), Expect = 6e-06
Identities = 87/406 (21%), Positives = 155/406 (38%), Gaps = 59/406 (14%)
Query: 33 SRYLAQIGDSVSLTCSTT-GCESPFFSWRTQIDSPLNGK---VTNEGTTSTLTMNPVSFG 88
S + +G+ + C G P SW+ SPL+ K +T G +T S
Sbjct: 138 SDVMVAVGEPAVMECQPPRGHPEPTISWKKD-GSPLDDKDERITIRGGKLMITYTRKSDA 196
Query: 89 NEHSYLCTATCESRKLEKGIQ----VEIYSFPKDPEIHLSGPLEAGKPITVKCSV-ADVY 143
+ Y+C T + E + +E SF K P + + KC D
Sbjct: 197 GK--YVCVGTNMVGERESEVAELTVLERPSFVKRPS---NLAVTVDDSAEFKCEARGDPV 251
Query: 144 PFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEV-TFTPVIED-IGKVLVCRAKLHI 201
P R D G+ E +D K + + ++ ++T V E+ +GK
Sbjct: 252 PTVRWRKD--DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA--------- 300
Query: 202 DEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK 261
E + TV+ + + P++ V+++ G +VT C + G P P IFW ++
Sbjct: 301 -EASATLTVQVGSEPPHFVVKPRDQVVAL--------GRTVTFQCEATGNPQPAIFWRRE 351
Query: 262 -----------LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIG----KNRKEVEL 306
+ + +S LT+ ++ D G Y+C+ +N+ G K EV
Sbjct: 352 GSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTD 411
Query: 307 IVQEKPFTVEISPGP-RIAAQIGDSVMLTCSVMGCESPSFSWRTQ--IDSPLSGKVRSEG 363
++ ++P V I GP + + +L+C G P+ WR + S +++ +
Sbjct: 412 VIADRPPPV-IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIK-QL 469
Query: 364 TNSTLTLSPVSFENEHSYLC--TVTCGHKKLEKGIQVELYSFPRDP 407
N L + + Y C + G I+V+ + P P
Sbjct: 470 ENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQP 515
Score = 37.0 bits (84), Expect = 0.066
Identities = 46/183 (25%), Positives = 68/183 (37%), Gaps = 24/183 (13%)
Query: 523 ILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGELQPLSENATLTLIS----------T 569
I+ +G + C ++G P P I W ++ + P S L S
Sbjct: 39 IVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRK 98
Query: 570 KMEDSGVYLCEGINQAGRS-RKEVELIIQVTPKDIKLTAFPSE-SVKEGDTVIISC-TCG 626
D GVY+C N G + L + + D + PS+ V G+ ++ C
Sbjct: 99 SRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN--PSDVMVAVGEPAVMECQPPR 156
Query: 627 NVPETWIILKKKAETGDTVLKSI---DGAYTIRKAQLKDAGVYECESKNKVG---SQLRS 680
PE I KK D + I G I + DAG Y C N VG S++
Sbjct: 157 GHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAE 216
Query: 681 LTL 683
LT+
Sbjct: 217 LTV 219
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 84.3 bits (207), Expect = 4e-16
Identities = 113/493 (22%), Positives = 193/493 (39%), Gaps = 67/493 (13%)
Query: 236 LQEGGSVTMTCSSEGLPAPEIFWSK--------KLDNGNLQHLSGNATLTLIAM-----R 282
+ +G T+ C +EG P P I W K K D + + L + +L + +
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKS 99
Query: 283 MEDSGIYVCEGVNLIGK---NRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSV-M 338
D G+YVC N +G+ + +E+ + F S + +G+ ++ C
Sbjct: 100 RPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD---VMVAVGEPAVMECQPPR 156
Query: 339 GCESPSFSWRTQIDSPLSGK---VRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKG 395
G P+ SW+ SPL K + G +T + S ++ + T G ++ E
Sbjct: 157 GHPEPTISWKKD-GSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVA 215
Query: 396 --IQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFL 453
+E SF + P + + S C+ P+ + GE E
Sbjct: 216 ELTVLERPSFVKRPS---NLAVTVDDSAEFKCEARGD-PVPTVRWRKDDGELPKSRYEIR 271
Query: 454 EDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRD 513
+D +K + T D G + C A+ + E ++ TL V V
Sbjct: 272 DDHTLKIRK---------VTAGDMG-SYTCVAENMVGKAE-------ASATLTVQVGSEP 314
Query: 514 TTVLVSP-SSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGEL---QP--------LSEN 561
+V P ++ G +V C + G P P I W R+ L QP +S+
Sbjct: 315 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 374
Query: 562 ATLTLISTKMEDSGVYLCEGINQAG----RSRKEVELIIQVTPKDIKLTAFPSESVKEGD 617
LT+ + + D G Y+C+ +N AG ++ EV +I P + +++V
Sbjct: 375 GDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG 434
Query: 618 TVIISCTCGNVPETWIILKKK---AETGDTVLKSID-GAYTIRKAQLKDAGVYECESKNK 673
T ++SC P I+ +K T D+ +K ++ G IR A+L D G Y C +
Sbjct: 435 TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP 494
Query: 674 VGSQLRSLTLDVQ 686
G S ++VQ
Sbjct: 495 SGEATWSAYIEVQ 507
Score = 69.3 bits (168), Expect = 1e-11
Identities = 124/541 (22%), Positives = 213/541 (39%), Gaps = 74/541 (13%)
Query: 91 HSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEA-GKPITVKCSVADVYPFDRLE 149
H YL C L G ++ FP H S + + G+P T+ C A+ P +E
Sbjct: 7 HFYLFGLIC----LCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCK-AEGRPTPTIE 61
Query: 150 IDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIE------DIGKVLVCRAKLHIDE 203
KG +++ + + R L + SL F ++ D G V VC A+ ++ E
Sbjct: 62 --WYKGGERVETDKDDPRSHRMLLPSGSL--FFLRIVHGRKSRPDEG-VYVCVARNYLGE 116
Query: 204 MDSV-PTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSS-EGLPAPEIFWSKK 261
S ++ A+ +P + +++V G M C G P P I W K
Sbjct: 117 AVSHNASLEVAILRDDFRQNPSDVMVAV--------GEPAVMECQPPRGHPEPTISWKKD 168
Query: 262 ---LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV-ELIVQEKPFTVEI 317
LD+ + + L + R D+G YVC G N++G+ EV EL V E+P V+
Sbjct: 169 GSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVK- 227
Query: 318 SPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFEN 377
+A + DS C G P+ WR D L + TL + V+ +
Sbjct: 228 -RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD-DGELPKSRYEIRDDHTLKIRKVTAGD 285
Query: 378 EHSYLCTV--TCGHKKLEKGIQVELYSFPRDPEIEMSGGLVN-GSSVTVSCKV-----PS 429
SY C G + + V++ S P ++ +V G +VT C+ P+
Sbjct: 286 MGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPA 345
Query: 430 VYPLDRLEIELL-----KGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQ 484
++ LL + ++ D + +++ + T+ G +++ +
Sbjct: 346 IFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAG-SIITK 404
Query: 485 AKLHIDDMEFE---PKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPA 541
A L + D+ + P RQ P + TV V + +L +C++ G P
Sbjct: 405 AYLEVTDVIADRPPPVIRQ---------GPVNQTVAVDGTFVL--------SCVATGSPV 447
Query: 542 PKILWSR-----QLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELII 596
P ILW + + ++ L EN L + K+ D+G Y C +G + + +
Sbjct: 448 PTILWRKDGVLVSTQDSRIKQL-ENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 506
Query: 597 Q 597
Q
Sbjct: 507 Q 507
Score = 50.4 bits (119), Expect = 6e-06
Identities = 87/406 (21%), Positives = 155/406 (38%), Gaps = 59/406 (14%)
Query: 33 SRYLAQIGDSVSLTCSTT-GCESPFFSWRTQIDSPLNGK---VTNEGTTSTLTMNPVSFG 88
S + +G+ + C G P SW+ SPL+ K +T G +T S
Sbjct: 138 SDVMVAVGEPAVMECQPPRGHPEPTISWKKD-GSPLDDKDERITIRGGKLMITYTRKSDA 196
Query: 89 NEHSYLCTATCESRKLEKGIQ----VEIYSFPKDPEIHLSGPLEAGKPITVKCSV-ADVY 143
+ Y+C T + E + +E SF K P + + KC D
Sbjct: 197 GK--YVCVGTNMVGERESEVAELTVLERPSFVKRPS---NLAVTVDDSAEFKCEARGDPV 251
Query: 144 PFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEV-TFTPVIED-IGKVLVCRAKLHI 201
P R D G+ E +D K + + ++ ++T V E+ +GK
Sbjct: 252 PTVRWRKD--DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA--------- 300
Query: 202 DEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK 261
E + TV+ + + P++ V+++ G +VT C + G P P IFW ++
Sbjct: 301 -EASATLTVQVGSEPPHFVVKPRDQVVAL--------GRTVTFQCEATGNPQPAIFWRRE 351
Query: 262 -----------LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIG----KNRKEVEL 306
+ + +S LT+ ++ D G Y+C+ +N+ G K EV
Sbjct: 352 GSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTD 411
Query: 307 IVQEKPFTVEISPGP-RIAAQIGDSVMLTCSVMGCESPSFSWRTQ--IDSPLSGKVRSEG 363
++ ++P V I GP + + +L+C G P+ WR + S +++ +
Sbjct: 412 VIADRPPPV-IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIK-QL 469
Query: 364 TNSTLTLSPVSFENEHSYLC--TVTCGHKKLEKGIQVELYSFPRDP 407
N L + + Y C + G I+V+ + P P
Sbjct: 470 ENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQP 515
Score = 37.0 bits (84), Expect = 0.066
Identities = 46/183 (25%), Positives = 68/183 (37%), Gaps = 24/183 (13%)
Query: 523 ILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGELQPLSENATLTLIS----------T 569
I+ +G + C ++G P P I W ++ + P S L S
Sbjct: 39 IVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRK 98
Query: 570 KMEDSGVYLCEGINQAGRS-RKEVELIIQVTPKDIKLTAFPSE-SVKEGDTVIISC-TCG 626
D GVY+C N G + L + + D + PS+ V G+ ++ C
Sbjct: 99 SRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN--PSDVMVAVGEPAVMECQPPR 156
Query: 627 NVPETWIILKKKAETGDTVLKSI---DGAYTIRKAQLKDAGVYECESKNKVG---SQLRS 680
PE I KK D + I G I + DAG Y C N VG S++
Sbjct: 157 GHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAE 216
Query: 681 LTL 683
LT+
Sbjct: 217 LTV 219
>gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo
sapiens]
Length = 848
Score = 82.0 bits (201), Expect = 2e-15
Identities = 96/447 (21%), Positives = 174/447 (38%), Gaps = 46/447 (10%)
Query: 8 ILGASNILWIMFAASQA--FKIETTPESRYLAQIGDSVSLTCSTTG-CESPFFSWRTQID 64
+L +++W +F A +++ P ++ +G+S C G + SW +
Sbjct: 1 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEIS-VGESKFFLCQVAGDAKDKDISWFSPNG 59
Query: 65 SPLNGK------VTNEGTTSTLTMNPVSFGNEHSYLCTATCES-RKLEKGIQVEIYSFPK 117
L V N+ ++STLT+ + + Y C T E + E + V+I+
Sbjct: 60 EKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLM 119
Query: 118 DPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKS 177
G+ + C V P + + L K F+ L+ +
Sbjct: 120 FKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIV-LSNNYLQIRG 178
Query: 178 LEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQ 237
++ T G++L R +++ ++ + V ++ Q VN + L
Sbjct: 179 IKKTDEGTYRCEGRILA-RGEINFKDIQVIVNVPPTIQARQNI---------VNATANL- 227
Query: 238 EGGSVTMTCSSEGLPAPEIFWSK-------KLDNGNLQHLSGNATLTLIAMRMEDSGIYV 290
G SVT+ C +EG P P + W+K + D+ ++ LT+ + D Y+
Sbjct: 228 -GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYI 286
Query: 291 CEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQ 350
C N G+ + L V KP + + A ++ + V LTC G PS +WRT
Sbjct: 287 CIAENKAGEQDATIHLKVFAKPKITYVE--NQTAMELEEQVTLTCEASGDPIPSITWRTS 344
Query: 351 I------DSPLSGK--VRSEGTNSTLTLSPVSFENEHSYLCTV--TCGHKKLEKGIQVEL 400
+ L G VRS S+LTL + + + Y+CT T G ++V+
Sbjct: 345 TRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQY 404
Query: 401 YSFPRDPEIEMSGGLVNGSSVTVSCKV 427
+ P + G+ V ++C+V
Sbjct: 405 APKLQGPVAVYTW---EGNQVNITCEV 428
Score = 80.5 bits (197), Expect = 5e-15
Identities = 94/396 (23%), Positives = 160/396 (40%), Gaps = 53/396 (13%)
Query: 235 KLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQH-----LSGNATLTLIAMRMEDSGIY 289
+ +EG + C P I W K + L+ + N L + ++ D G Y
Sbjct: 128 EFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTY 187
Query: 290 VCEGVNLIGK--NRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSW 347
CEG L N K++++IV P A +G SV L C G P+ SW
Sbjct: 188 RCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSW 247
Query: 348 RT---QIDSPLSG-KVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSF 403
QI+ K +S LT+ V +E Y+C + + I +++++
Sbjct: 248 TKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK 307
Query: 404 PRDPEIEMSGGLVNGSSVTVSCK-----VPSVYPLDRLEIELLKGETILENIEFLEDTDM 458
P+ +E + VT++C+ +PS+ + +T+ ++ +
Sbjct: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
Query: 459 KSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNV--APRDTTV 516
SL KS++ T D G+ +C A I Q +Q++Y+ V AP+
Sbjct: 368 SSLTLKSIQYT------DAGE-YICTASNTIG---------QDSQSMYLEVQYAPK---- 407
Query: 517 LVSPSSILE-EGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKM---- 571
L P ++ EG+ VN+TC +P+ I W R +G+L P S + + + +T
Sbjct: 408 LQGPVAVYTWEGNQVNITCEVFAYPSATISWFR---DGQLLPSSNYSNIKIYNTPSASYL 464
Query: 572 -------EDSGVYLCEGINQAGRSRKEVELIIQVTP 600
D G Y C +N+ G+ E L+ TP
Sbjct: 465 EVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 500
Score = 74.3 bits (181), Expect = 4e-13
Identities = 99/436 (22%), Positives = 178/436 (40%), Gaps = 56/436 (12%)
Query: 273 NATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFT---VEISPGPRIAAQIGD 329
++TLT+ ++D+GIY C + G++ E E V K F + +P P+ + G+
Sbjct: 78 SSTLTIYNANIDDAGIYKCV---VTGEDGSESEATVNVKIFQKLMFKNAPTPQEFRE-GE 133
Query: 330 SVMLTCSVMGCESPSFSWRTQ-IDSPLSGKVRSEG-TNSTLTLSPVSFENEHSYLCT--V 385
++ C V+ P+ W+ + D L VR +N+ L + + +E +Y C +
Sbjct: 134 DAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRI 193
Query: 386 TCGHKKLEKGIQVELYSFPRDPEIEMSGGLVN-----GSSVTVSCKVPSVYPLDRLEIEL 440
+ K IQV + + P P I+ +VN G SVT+ C +
Sbjct: 194 LARGEINFKDIQV-IVNVP--PTIQARQNIVNATANLGQSVTLVCDA------EGFPEPT 244
Query: 441 LKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQ 500
+ E IE ED + + S ++T ++ +C A E K +
Sbjct: 245 MSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIA---------ENKAGE 295
Query: 501 STQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGE--- 554
T+++ V + V + +E V +TC + G P P I W +R + + E
Sbjct: 296 QDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTL 355
Query: 555 -----LQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFP 609
++ + ++LTL S + D+G Y+C N G+ + + L +Q P KL
Sbjct: 356 DGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP---KLQGPV 412
Query: 610 SESVKEGDTVIISCTCGNVPETWI-------ILKKKAETGDTVLKSIDGAY-TIRKAQLK 661
+ EG+ V I+C P I +L + + + +Y +
Sbjct: 413 AVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSEN 472
Query: 662 DAGVYECESKNKVGSQ 677
D G Y C + N++G +
Sbjct: 473 DFGNYNCTAVNRIGQE 488
Score = 70.5 bits (171), Expect = 5e-12
Identities = 80/387 (20%), Positives = 157/387 (40%), Gaps = 43/387 (11%)
Query: 327 IGDSVMLTCSVMG-CESPSFSWRTQIDSPLSGK------VRSEGTNSTLTLSPVSFENEH 379
+G+S C V G + SW + L+ V ++ ++STLT+ + ++
Sbjct: 33 VGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAG 92
Query: 380 SYLCTVTCGH-KKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEI 438
Y C VT + E + V+++ G + C V S P +
Sbjct: 93 IYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWK 152
Query: 439 ELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQ 498
+ + +++ F+ ++ L+ + ++ T T G+ L + +++ D++
Sbjct: 153 HKGRDVILKKDVRFIVLSN-NYLQIRGIKKTDEGTYRCEGRILA-RGEINFKDIQ----- 205
Query: 499 RQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSR------QLPN 552
+ VNV P ++ G SV + C ++GFP P + W++ Q +
Sbjct: 206 ------VIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259
Query: 553 GELQPLSENAT-LTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSE 611
E S++++ LT+ D Y+C N+AG + L + PK +T ++
Sbjct: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPK---ITYVENQ 316
Query: 612 SVKE-GDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDG-----------AYTIRKAQ 659
+ E + V ++C P I + + K++DG + T++ Q
Sbjct: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ 376
Query: 660 LKDAGVYECESKNKVGSQLRSLTLDVQ 686
DAG Y C + N +G +S+ L+VQ
Sbjct: 377 YTDAGEYICTASNTIGQDSQSMYLEVQ 403
Score = 56.2 bits (134), Expect = 1e-07
Identities = 73/302 (24%), Positives = 117/302 (38%), Gaps = 42/302 (13%)
Query: 37 AQIGDSVSLTCSTTGCESPFFSWRT---QIDSPLNG-KVTNEGTTSTLTMNPVSFGNEHS 92
A +G SV+L C G P SW QI+ + K +S LT+ V +E
Sbjct: 225 ANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAE 284
Query: 93 YLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVA-DVYPFDRLEID 151
Y+C A ++ + + I +++++ PK + +E + +T+ C + D P I
Sbjct: 285 YICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIP----SIT 340
Query: 152 LLKGDHLMKSQEFLED--------ADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDE 203
+ S+E D A SL KS++ T D G+ +C A I +
Sbjct: 341 WRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT------DAGEY-ICTASNTIGQ 393
Query: 204 MDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW----- 258
DS L+V +PK + + EG V +TC P+ I W
Sbjct: 394 -DSQSMY------LEVQYAPK---LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQ 443
Query: 259 ---SKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTV 315
S N + + + L + D G Y C VN IG+ E L+ + P +
Sbjct: 444 LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSP 503
Query: 316 EI 317
I
Sbjct: 504 SI 505
>gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo
sapiens]
Length = 761
Score = 82.0 bits (201), Expect = 2e-15
Identities = 96/447 (21%), Positives = 174/447 (38%), Gaps = 46/447 (10%)
Query: 8 ILGASNILWIMFAASQA--FKIETTPESRYLAQIGDSVSLTCSTTG-CESPFFSWRTQID 64
+L +++W +F A +++ P ++ +G+S C G + SW +
Sbjct: 1 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEIS-VGESKFFLCQVAGDAKDKDISWFSPNG 59
Query: 65 SPLNGK------VTNEGTTSTLTMNPVSFGNEHSYLCTATCES-RKLEKGIQVEIYSFPK 117
L V N+ ++STLT+ + + Y C T E + E + V+I+
Sbjct: 60 EKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLM 119
Query: 118 DPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKS 177
G+ + C V P + + L K F+ L+ +
Sbjct: 120 FKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIV-LSNNYLQIRG 178
Query: 178 LEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQ 237
++ T G++L R +++ ++ + V ++ Q VN + L
Sbjct: 179 IKKTDEGTYRCEGRILA-RGEINFKDIQVIVNVPPTIQARQNI---------VNATANL- 227
Query: 238 EGGSVTMTCSSEGLPAPEIFWSK-------KLDNGNLQHLSGNATLTLIAMRMEDSGIYV 290
G SVT+ C +EG P P + W+K + D+ ++ LT+ + D Y+
Sbjct: 228 -GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYI 286
Query: 291 CEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQ 350
C N G+ + L V KP + + A ++ + V LTC G PS +WRT
Sbjct: 287 CIAENKAGEQDATIHLKVFAKPKITYVE--NQTAMELEEQVTLTCEASGDPIPSITWRTS 344
Query: 351 I------DSPLSGK--VRSEGTNSTLTLSPVSFENEHSYLCTV--TCGHKKLEKGIQVEL 400
+ L G VRS S+LTL + + + Y+CT T G ++V+
Sbjct: 345 TRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQY 404
Query: 401 YSFPRDPEIEMSGGLVNGSSVTVSCKV 427
+ P + G+ V ++C+V
Sbjct: 405 APKLQGPVAVYTW---EGNQVNITCEV 428
Score = 80.5 bits (197), Expect = 5e-15
Identities = 94/396 (23%), Positives = 160/396 (40%), Gaps = 53/396 (13%)
Query: 235 KLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQH-----LSGNATLTLIAMRMEDSGIY 289
+ +EG + C P I W K + L+ + N L + ++ D G Y
Sbjct: 128 EFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTY 187
Query: 290 VCEGVNLIGK--NRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSW 347
CEG L N K++++IV P A +G SV L C G P+ SW
Sbjct: 188 RCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSW 247
Query: 348 RT---QIDSPLSG-KVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSF 403
QI+ K +S LT+ V +E Y+C + + I +++++
Sbjct: 248 TKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK 307
Query: 404 PRDPEIEMSGGLVNGSSVTVSCK-----VPSVYPLDRLEIELLKGETILENIEFLEDTDM 458
P+ +E + VT++C+ +PS+ + +T+ ++ +
Sbjct: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
Query: 459 KSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNV--APRDTTV 516
SL KS++ T D G+ +C A I Q +Q++Y+ V AP+
Sbjct: 368 SSLTLKSIQYT------DAGE-YICTASNTIG---------QDSQSMYLEVQYAPK---- 407
Query: 517 LVSPSSILE-EGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKM---- 571
L P ++ EG+ VN+TC +P+ I W R +G+L P S + + + +T
Sbjct: 408 LQGPVAVYTWEGNQVNITCEVFAYPSATISWFR---DGQLLPSSNYSNIKIYNTPSASYL 464
Query: 572 -------EDSGVYLCEGINQAGRSRKEVELIIQVTP 600
D G Y C +N+ G+ E L+ TP
Sbjct: 465 EVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 500
Score = 74.3 bits (181), Expect = 4e-13
Identities = 99/436 (22%), Positives = 178/436 (40%), Gaps = 56/436 (12%)
Query: 273 NATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFT---VEISPGPRIAAQIGD 329
++TLT+ ++D+GIY C + G++ E E V K F + +P P+ + G+
Sbjct: 78 SSTLTIYNANIDDAGIYKCV---VTGEDGSESEATVNVKIFQKLMFKNAPTPQEFRE-GE 133
Query: 330 SVMLTCSVMGCESPSFSWRTQ-IDSPLSGKVRSEG-TNSTLTLSPVSFENEHSYLCT--V 385
++ C V+ P+ W+ + D L VR +N+ L + + +E +Y C +
Sbjct: 134 DAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRI 193
Query: 386 TCGHKKLEKGIQVELYSFPRDPEIEMSGGLVN-----GSSVTVSCKVPSVYPLDRLEIEL 440
+ K IQV + + P P I+ +VN G SVT+ C +
Sbjct: 194 LARGEINFKDIQV-IVNVP--PTIQARQNIVNATANLGQSVTLVCDA------EGFPEPT 244
Query: 441 LKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQ 500
+ E IE ED + + S ++T ++ +C A E K +
Sbjct: 245 MSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIA---------ENKAGE 295
Query: 501 STQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGE--- 554
T+++ V + V + +E V +TC + G P P I W +R + + E
Sbjct: 296 QDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTL 355
Query: 555 -----LQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFP 609
++ + ++LTL S + D+G Y+C N G+ + + L +Q P KL
Sbjct: 356 DGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP---KLQGPV 412
Query: 610 SESVKEGDTVIISCTCGNVPETWI-------ILKKKAETGDTVLKSIDGAY-TIRKAQLK 661
+ EG+ V I+C P I +L + + + +Y +
Sbjct: 413 AVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSEN 472
Query: 662 DAGVYECESKNKVGSQ 677
D G Y C + N++G +
Sbjct: 473 DFGNYNCTAVNRIGQE 488
Score = 70.5 bits (171), Expect = 5e-12
Identities = 80/387 (20%), Positives = 157/387 (40%), Gaps = 43/387 (11%)
Query: 327 IGDSVMLTCSVMG-CESPSFSWRTQIDSPLSGK------VRSEGTNSTLTLSPVSFENEH 379
+G+S C V G + SW + L+ V ++ ++STLT+ + ++
Sbjct: 33 VGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAG 92
Query: 380 SYLCTVTCGH-KKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEI 438
Y C VT + E + V+++ G + C V S P +
Sbjct: 93 IYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWK 152
Query: 439 ELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQ 498
+ + +++ F+ ++ L+ + ++ T T G+ L + +++ D++
Sbjct: 153 HKGRDVILKKDVRFIVLSN-NYLQIRGIKKTDEGTYRCEGRILA-RGEINFKDIQ----- 205
Query: 499 RQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSR------QLPN 552
+ VNV P ++ G SV + C ++GFP P + W++ Q +
Sbjct: 206 ------VIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259
Query: 553 GELQPLSENAT-LTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSE 611
E S++++ LT+ D Y+C N+AG + L + PK +T ++
Sbjct: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPK---ITYVENQ 316
Query: 612 SVKE-GDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDG-----------AYTIRKAQ 659
+ E + V ++C P I + + K++DG + T++ Q
Sbjct: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ 376
Query: 660 LKDAGVYECESKNKVGSQLRSLTLDVQ 686
DAG Y C + N +G +S+ L+VQ
Sbjct: 377 YTDAGEYICTASNTIGQDSQSMYLEVQ 403
Score = 56.2 bits (134), Expect = 1e-07
Identities = 73/302 (24%), Positives = 117/302 (38%), Gaps = 42/302 (13%)
Query: 37 AQIGDSVSLTCSTTGCESPFFSWRT---QIDSPLNG-KVTNEGTTSTLTMNPVSFGNEHS 92
A +G SV+L C G P SW QI+ + K +S LT+ V +E
Sbjct: 225 ANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAE 284
Query: 93 YLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVA-DVYPFDRLEID 151
Y+C A ++ + + I +++++ PK + +E + +T+ C + D P I
Sbjct: 285 YICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIP----SIT 340
Query: 152 LLKGDHLMKSQEFLED--------ADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDE 203
+ S+E D A SL KS++ T D G+ +C A I +
Sbjct: 341 WRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT------DAGEY-ICTASNTIGQ 393
Query: 204 MDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW----- 258
DS L+V +PK + + EG V +TC P+ I W
Sbjct: 394 -DSQSMY------LEVQYAPK---LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQ 443
Query: 259 ---SKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTV 315
S N + + + L + D G Y C VN IG+ E L+ + P +
Sbjct: 444 LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSP 503
Query: 316 EI 317
I
Sbjct: 504 SI 505
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 81.6 bits (200), Expect = 2e-15
Identities = 113/492 (22%), Positives = 190/492 (38%), Gaps = 68/492 (13%)
Query: 236 LQEGGSVTMTCSSEGLPAPEIFWSK--------KLDNGNLQHLSGNATLTLIAM-----R 282
+ +G T+ C +EG P P I W K K D + + L + +L + +
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKS 99
Query: 283 MEDSGIYVCEGVNLIGK---NRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSV-M 338
D G+YVC N +G+ + +E+ + F S + +G+ ++ C
Sbjct: 100 RPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD---VMVAVGEPAVMECQPPR 156
Query: 339 GCESPSFSWRTQIDSPLSGK---VRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKG 395
G P+ SW+ SPL K + G +T + S ++ + T G ++ E
Sbjct: 157 GHPEPTISWKKD-GSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVA 215
Query: 396 --IQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFL 453
+E SF + P + + S C+ P+ + GE E
Sbjct: 216 ELTVLERPSFVKRPS---NLAVTVDDSAEFKCEARGD-PVPTVRWRKDDGELPKSRYEIR 271
Query: 454 EDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRD 513
+D +K + T D G + C A+ + E +V V PRD
Sbjct: 272 DDHTLKIRK---------VTAGDMG-SYTCVAENMVGKAEASATLTVQEPPHFV-VKPRD 320
Query: 514 TTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGEL---QP--------LSENA 562
V + G +V C + G P P I W R+ L QP +S+
Sbjct: 321 QVVAL--------GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 372
Query: 563 TLTLISTKMEDSGVYLCEGINQAG----RSRKEVELIIQVTPKDIKLTAFPSESVKEGDT 618
LT+ + + D G Y+C+ +N AG ++ EV +I P + +++V T
Sbjct: 373 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 432
Query: 619 VIISCTCGNVPETWIILKKK---AETGDTVLKSID-GAYTIRKAQLKDAGVYECESKNKV 674
++SC P I+ +K T D+ +K ++ G IR A+L D G Y C +
Sbjct: 433 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 492
Query: 675 GSQLRSLTLDVQ 686
G S ++VQ
Sbjct: 493 GEATWSAYIEVQ 504
Score = 68.9 bits (167), Expect = 2e-11
Identities = 122/538 (22%), Positives = 207/538 (38%), Gaps = 71/538 (13%)
Query: 91 HSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEA-GKPITVKCSVADVYPFDRLE 149
H YL C L G ++ FP H S + + G+P T+ C A+ P +E
Sbjct: 7 HFYLFGLIC----LCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCK-AEGRPTPTIE 61
Query: 150 IDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIE------DIGKVLVCRAKLHIDE 203
KG +++ + + R L + SL F ++ D G V VC A+ ++ E
Sbjct: 62 --WYKGGERVETDKDDPRSHRMLLPSGSL--FFLRIVHGRKSRPDEG-VYVCVARNYLGE 116
Query: 204 MDSV-PTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSS-EGLPAPEIFWSKK 261
S ++ A+ +P + +++V G M C G P P I W K
Sbjct: 117 AVSHNASLEVAILRDDFRQNPSDVMVAV--------GEPAVMECQPPRGHPEPTISWKKD 168
Query: 262 ---LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV-ELIVQEKPFTVEI 317
LD+ + + L + R D+G YVC G N++G+ EV EL V E+P V+
Sbjct: 169 GSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVK- 227
Query: 318 SPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFEN 377
+A + DS C G P+ WR D L + TL + V+ +
Sbjct: 228 -RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD-DGELPKSRYEIRDDHTLKIRKVTAGD 285
Query: 378 EHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKV-----PSVYP 432
SY C K E + + P + G +VT C+ P+++
Sbjct: 286 MGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFW 345
Query: 433 LDRLEIELL-----KGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKL 487
LL + ++ D + +++ + T+ G +++ +A L
Sbjct: 346 RREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAG-SIITKAYL 404
Query: 488 HIDDMEFE---PKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKI 544
+ D+ + P RQ P + TV V + +L +C++ G P P I
Sbjct: 405 EVTDVIADRPPPVIRQ---------GPVNQTVAVDGTFVL--------SCVATGSPVPTI 447
Query: 545 LWSR-----QLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQ 597
LW + + ++ L EN L + K+ D+G Y C +G + + +Q
Sbjct: 448 LWRKDGVLVSTQDSRIKQL-ENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 504
Score = 48.1 bits (113), Expect = 3e-05
Identities = 45/207 (21%), Positives = 85/207 (41%), Gaps = 30/207 (14%)
Query: 221 ISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK-----------LDNGNLQH 269
+ P++ V+++ G +VT C + G P P IFW ++ + +
Sbjct: 316 VKPRDQVVAL--------GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 367
Query: 270 LSGNATLTLIAMRMEDSGIYVCEGVNLIG----KNRKEVELIVQEKPFTVEISPGP-RIA 324
+S LT+ ++ D G Y+C+ +N+ G K EV ++ ++P V I GP
Sbjct: 368 VSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV-IRQGPVNQT 426
Query: 325 AQIGDSVMLTCSVMGCESPSFSWRTQ--IDSPLSGKVRSEGTNSTLTLSPVSFENEHSYL 382
+ + +L+C G P+ WR + S +++ + N L + + Y
Sbjct: 427 VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIK-QLENGVLQIRYAKLGDTGRYT 485
Query: 383 C--TVTCGHKKLEKGIQVELYSFPRDP 407
C + G I+V+ + P P
Sbjct: 486 CIASTPSGEATWSAYIEVQEFGVPVQP 512
Score = 37.0 bits (84), Expect = 0.066
Identities = 46/183 (25%), Positives = 68/183 (37%), Gaps = 24/183 (13%)
Query: 523 ILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGELQPLSENATLTLIS----------T 569
I+ +G + C ++G P P I W ++ + P S L S
Sbjct: 39 IVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRK 98
Query: 570 KMEDSGVYLCEGINQAGRS-RKEVELIIQVTPKDIKLTAFPSE-SVKEGDTVIISC-TCG 626
D GVY+C N G + L + + D + PS+ V G+ ++ C
Sbjct: 99 SRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN--PSDVMVAVGEPAVMECQPPR 156
Query: 627 NVPETWIILKKKAETGDTVLKSI---DGAYTIRKAQLKDAGVYECESKNKVG---SQLRS 680
PE I KK D + I G I + DAG Y C N VG S++
Sbjct: 157 GHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAE 216
Query: 681 LTL 683
LT+
Sbjct: 217 LTV 219
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 81.6 bits (200), Expect = 2e-15
Identities = 113/492 (22%), Positives = 190/492 (38%), Gaps = 68/492 (13%)
Query: 236 LQEGGSVTMTCSSEGLPAPEIFWSK--------KLDNGNLQHLSGNATLTLIAM-----R 282
+ +G T+ C +EG P P I W K K D + + L + +L + +
Sbjct: 79 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKS 138
Query: 283 MEDSGIYVCEGVNLIGK---NRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSV-M 338
D G+YVC N +G+ + +E+ + F S + +G+ ++ C
Sbjct: 139 RPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD---VMVAVGEPAVMECQPPR 195
Query: 339 GCESPSFSWRTQIDSPLSGK---VRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKG 395
G P+ SW+ SPL K + G +T + S ++ + T G ++ E
Sbjct: 196 GHPEPTISWKKD-GSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVA 254
Query: 396 --IQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFL 453
+E SF + P + + S C+ P+ + GE E
Sbjct: 255 ELTVLERPSFVKRPS---NLAVTVDDSAEFKCEARGD-PVPTVRWRKDDGELPKSRYEIR 310
Query: 454 EDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRD 513
+D +K + T D G + C A+ + E +V V PRD
Sbjct: 311 DDHTLKIRK---------VTAGDMG-SYTCVAENMVGKAEASATLTVQEPPHFV-VKPRD 359
Query: 514 TTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGEL---QP--------LSENA 562
V + G +V C + G P P I W R+ L QP +S+
Sbjct: 360 QVVAL--------GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 411
Query: 563 TLTLISTKMEDSGVYLCEGINQAG----RSRKEVELIIQVTPKDIKLTAFPSESVKEGDT 618
LT+ + + D G Y+C+ +N AG ++ EV +I P + +++V T
Sbjct: 412 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 471
Query: 619 VIISCTCGNVPETWIILKKK---AETGDTVLKSID-GAYTIRKAQLKDAGVYECESKNKV 674
++SC P I+ +K T D+ +K ++ G IR A+L D G Y C +
Sbjct: 472 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 531
Query: 675 GSQLRSLTLDVQ 686
G S ++VQ
Sbjct: 532 GEATWSAYIEVQ 543
Score = 68.6 bits (166), Expect = 2e-11
Identities = 90/391 (23%), Positives = 149/391 (38%), Gaps = 46/391 (11%)
Query: 231 NPS-TKLQEGGSVTMTCSS-EGLPAPEIFWSKK---LDNGNLQHLSGNATLTLIAMRMED 285
NPS + G M C G P P I W K LD+ + + L + R D
Sbjct: 175 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSD 234
Query: 286 SGIYVCEGVNLIGKNRKEV-ELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPS 344
+G YVC G N++G+ EV EL V E+P V+ +A + DS C G P+
Sbjct: 235 AGKYVCVGTNMVGERESEVAELTVLERPSFVK--RPSNLAVTVDDSAEFKCEARGDPVPT 292
Query: 345 FSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFP 404
WR D L + TL + V+ + SY C K E + + P
Sbjct: 293 VRWRKD-DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPP 351
Query: 405 RDPEIEMSGGLVNGSSVTVSCKV-----PSVYPLDRLEIELL-----KGETILENIEFLE 454
+ G +VT C+ P+++ LL + ++
Sbjct: 352 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 411
Query: 455 DTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFE---PKQRQSTQTLYVNVAP 511
D + +++ + T+ G +++ +A L + D+ + P RQ P
Sbjct: 412 DLTITNVQRSDVGYYICQTLNVAG-SIITKAYLEVTDVIADRPPPVIRQ---------GP 461
Query: 512 RDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSR-----QLPNGELQPLSENATLTL 566
+ TV V + +L +C++ G P P ILW + + ++ L EN L +
Sbjct: 462 VNQTVAVDGTFVL--------SCVATGSPVPTILWRKDGVLVSTQDSRIKQL-ENGVLQI 512
Query: 567 ISTKMEDSGVYLCEGINQAGRSRKEVELIIQ 597
K+ D+G Y C +G + + +Q
Sbjct: 513 RYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 543
Score = 48.1 bits (113), Expect = 3e-05
Identities = 45/207 (21%), Positives = 85/207 (41%), Gaps = 30/207 (14%)
Query: 221 ISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK-----------LDNGNLQH 269
+ P++ V+++ G +VT C + G P P IFW ++ + +
Sbjct: 355 VKPRDQVVAL--------GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 406
Query: 270 LSGNATLTLIAMRMEDSGIYVCEGVNLIG----KNRKEVELIVQEKPFTVEISPGP-RIA 324
+S LT+ ++ D G Y+C+ +N+ G K EV ++ ++P V I GP
Sbjct: 407 VSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV-IRQGPVNQT 465
Query: 325 AQIGDSVMLTCSVMGCESPSFSWRTQ--IDSPLSGKVRSEGTNSTLTLSPVSFENEHSYL 382
+ + +L+C G P+ WR + S +++ + N L + + Y
Sbjct: 466 VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIK-QLENGVLQIRYAKLGDTGRYT 524
Query: 383 C--TVTCGHKKLEKGIQVELYSFPRDP 407
C + G I+V+ + P P
Sbjct: 525 CIASTPSGEATWSAYIEVQEFGVPVQP 551
Score = 37.0 bits (84), Expect = 0.066
Identities = 46/183 (25%), Positives = 68/183 (37%), Gaps = 24/183 (13%)
Query: 523 ILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGELQPLSENATLTLIS----------T 569
I+ +G + C ++G P P I W ++ + P S L S
Sbjct: 78 IVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRK 137
Query: 570 KMEDSGVYLCEGINQAGRS-RKEVELIIQVTPKDIKLTAFPSE-SVKEGDTVIISC-TCG 626
D GVY+C N G + L + + D + PS+ V G+ ++ C
Sbjct: 138 SRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN--PSDVMVAVGEPAVMECQPPR 195
Query: 627 NVPETWIILKKKAETGDTVLKSI---DGAYTIRKAQLKDAGVYECESKNKVG---SQLRS 680
PE I KK D + I G I + DAG Y C N VG S++
Sbjct: 196 GHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAE 255
Query: 681 LTL 683
LT+
Sbjct: 256 LTV 258
>gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo
sapiens]
Length = 858
Score = 77.4 bits (189), Expect = 4e-14
Identities = 95/457 (20%), Positives = 174/457 (38%), Gaps = 56/457 (12%)
Query: 8 ILGASNILWIMFAASQA--FKIETTPESRYLAQIGDSVSLTCSTTG-CESPFFSWRTQID 64
+L +++W +F A +++ P ++ +G+S C G + SW +
Sbjct: 1 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEIS-VGESKFFLCQVAGDAKDKDISWFSPNG 59
Query: 65 SPLNGK------VTNEGTTSTLTMNPVSFGNEHSYLCTATCES-RKLEKGIQVEIYSFPK 117
L V N+ ++STLT+ + + Y C T E + E + V+I+
Sbjct: 60 EKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLM 119
Query: 118 DPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKS 177
G+ + C V P + + L K F+ L+ +
Sbjct: 120 FKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIV-LSNNYLQIRG 178
Query: 178 LEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQ 237
++ T G++L R +++ ++ + V ++ Q VN + L
Sbjct: 179 IKKTDEGTYRCEGRILA-RGEINFKDIQVIVNVPPTIQARQNI---------VNATANL- 227
Query: 238 EGGSVTMTCSSEGLPAPEIFWSK-------KLDNGNLQHLSGNATLTLIAMRMEDSGIYV 290
G SVT+ C +EG P P + W+K + D+ ++ LT+ + D Y+
Sbjct: 228 -GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYI 286
Query: 291 CEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQ 350
C N G+ + L V KP + + A ++ + V LTC G PS +WRT
Sbjct: 287 CIAENKAGEQDATIHLKVFAKPKITYVE--NQTAMELEEQVTLTCEASGDPIPSITWRTS 344
Query: 351 IDSPLSGK------------------VRSEGTNSTLTLSPVSFENEHSYLCTV--TCGHK 390
+ S + VRS S+LTL + + + Y+CT T G
Sbjct: 345 TRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQD 404
Query: 391 KLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKV 427
++V+ + P + G+ V ++C+V
Sbjct: 405 SQSMYLEVQYAPKLQGPVAVYTW---EGNQVNITCEV 438
Score = 77.4 bits (189), Expect = 4e-14
Identities = 97/406 (23%), Positives = 162/406 (39%), Gaps = 63/406 (15%)
Query: 235 KLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQH-----LSGNATLTLIAMRMEDSGIY 289
+ +EG + C P I W K + L+ + N L + ++ D G Y
Sbjct: 128 EFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTY 187
Query: 290 VCEGVNLIGK--NRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSW 347
CEG L N K++++IV P A +G SV L C G P+ SW
Sbjct: 188 RCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSW 247
Query: 348 RT---QIDSPLSG-KVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSF 403
QI+ K +S LT+ V +E Y+C + + I +++++
Sbjct: 248 TKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK 307
Query: 404 PRDPEIEMSGGLVNGSSVTVSCK-----VPSV-YPLDRLEIELL---------KGETILE 448
P+ +E + VT++C+ +PS+ + I K ET+
Sbjct: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDG 367
Query: 449 NIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVN 508
++ + SL KS++ T D G+ +C A I Q +Q++Y+
Sbjct: 368 HMVVRSHARVSSLTLKSIQYT------DAGE-YICTASNTIG---------QDSQSMYLE 411
Query: 509 V--APRDTTVLVSPSSILE-EGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLT 565
V AP+ L P ++ EG+ VN+TC +P+ I W R +G+L P S + +
Sbjct: 412 VQYAPK----LQGPVAVYTWEGNQVNITCEVFAYPSATISWFR---DGQLLPSSNYSNIK 464
Query: 566 LISTKM-----------EDSGVYLCEGINQAGRSRKEVELIIQVTP 600
+ +T D G Y C +N+ G+ E L+ TP
Sbjct: 465 IYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 510
Score = 70.5 bits (171), Expect = 5e-12
Identities = 99/446 (22%), Positives = 178/446 (39%), Gaps = 66/446 (14%)
Query: 273 NATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFT---VEISPGPRIAAQIGD 329
++TLT+ ++D+GIY C + G++ E E V K F + +P P+ + G+
Sbjct: 78 SSTLTIYNANIDDAGIYKCV---VTGEDGSESEATVNVKIFQKLMFKNAPTPQEFRE-GE 133
Query: 330 SVMLTCSVMGCESPSFSWRTQ-IDSPLSGKVRSEG-TNSTLTLSPVSFENEHSYLCT--V 385
++ C V+ P+ W+ + D L VR +N+ L + + +E +Y C +
Sbjct: 134 DAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRI 193
Query: 386 TCGHKKLEKGIQVELYSFPRDPEIEMSGGLVN-----GSSVTVSCKVPSVYPLDRLEIEL 440
+ K IQV + + P P I+ +VN G SVT+ C +
Sbjct: 194 LARGEINFKDIQV-IVNVP--PTIQARQNIVNATANLGQSVTLVCDA------EGFPEPT 244
Query: 441 LKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQ 500
+ E IE ED + + S ++T ++ +C A E K +
Sbjct: 245 MSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIA---------ENKAGE 295
Query: 501 STQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILW---SRQLPNGE--- 554
T+++ V + V + +E V +TC + G P P I W +R + + E
Sbjct: 296 QDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKAS 355
Query: 555 ---------------LQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVT 599
++ + ++LTL S + D+G Y+C N G+ + + L +Q
Sbjct: 356 WTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYA 415
Query: 600 PKDIKLTAFPSESVKEGDTVIISCTCGNVPETWI-------ILKKKAETGDTVLKSIDGA 652
P KL + EG+ V I+C P I +L + + + +
Sbjct: 416 P---KLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSAS 472
Query: 653 Y-TIRKAQLKDAGVYECESKNKVGSQ 677
Y + D G Y C + N++G +
Sbjct: 473 YLEVTPDSENDFGNYNCTAVNRIGQE 498
Score = 65.9 bits (159), Expect = 1e-10
Identities = 82/394 (20%), Positives = 160/394 (40%), Gaps = 47/394 (11%)
Query: 327 IGDSVMLTCSVMG-CESPSFSWRTQIDSPLSGK------VRSEGTNSTLTLSPVSFENEH 379
+G+S C V G + SW + L+ V ++ ++STLT+ + ++
Sbjct: 33 VGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAG 92
Query: 380 SYLCTVTCGH-KKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEI 438
Y C VT + E + V+++ G + C V S P +
Sbjct: 93 IYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWK 152
Query: 439 ELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQ 498
+ + +++ F+ ++ L+ + ++ T T G+ L + +++ D++
Sbjct: 153 HKGRDVILKKDVRFIVLSN-NYLQIRGIKKTDEGTYRCEGRILA-RGEINFKDIQ----- 205
Query: 499 RQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSR------QLPN 552
+ VNV P ++ G SV + C ++GFP P + W++ Q +
Sbjct: 206 ------VIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259
Query: 553 GELQPLSENAT-LTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSE 611
E S++++ LT+ D Y+C N+AG + L + PK + +
Sbjct: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
Query: 612 SVKEGDTVIISCTCGNVPE-TW------IILKKKAE-TGDTVLKSIDG-----------A 652
++E T+ + +P TW I ++KA T +++DG +
Sbjct: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSS 379
Query: 653 YTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 686
T++ Q DAG Y C + N +G +S+ L+VQ
Sbjct: 380 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ 413
Score = 53.5 bits (127), Expect = 7e-07
Identities = 66/304 (21%), Positives = 116/304 (38%), Gaps = 36/304 (11%)
Query: 37 AQIGDSVSLTCSTTGCESPFFSWRT---QIDSPLNG-KVTNEGTTSTLTMNPVSFGNEHS 92
A +G SV+L C G P SW QI+ + K +S LT+ V +E
Sbjct: 225 ANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAE 284
Query: 93 YLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVA-DVYPFDRLEID 151
Y+C A ++ + + I +++++ PK + +E + +T+ C + D P I
Sbjct: 285 YICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIP----SIT 340
Query: 152 LLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKV--LVCRAKLHIDEMDSVPT 209
+ S+E + ET + V+ +V L ++ + D + + T
Sbjct: 341 WRTSTRNISSEEKASWTRPEKQETLDGHM----VVRSHARVSSLTLKSIQYTDAGEYICT 396
Query: 210 VRQAVKELQVYISPKNTVISVNPSTKLQ--------EGGSVTMTCSSEGLPAPEIFW--- 258
+ + ++ + V + KLQ EG V +TC P+ I W
Sbjct: 397 ASNTIGQ-----DSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRD 451
Query: 259 -----SKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPF 313
S N + + + L + D G Y C VN IG+ E L+ + P
Sbjct: 452 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPS 511
Query: 314 TVEI 317
+ I
Sbjct: 512 SPSI 515
>gi|13489095 sialoadhesin precursor [Homo sapiens]
Length = 1709
Score = 77.0 bits (188), Expect = 6e-14
Identities = 161/721 (22%), Positives = 261/721 (36%), Gaps = 116/721 (16%)
Query: 21 ASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTL 80
A + KI +P R + G+ V+LTC S + D V + T L
Sbjct: 237 APKGVKILLSPSGRNILP-GELVTLTCQVNSSYPAVSSIKWLKDG-----VRLQTKTGVL 290
Query: 81 TMNPVSFGNEHSYLCTATCESRKLEKGI------QVEIYSFPKDPEIHLSGPLEAGKPIT 134
+ ++ + Y C A E G+ + ++ F + ++ +GP+ + +T
Sbjct: 291 HLPQAAWSDAGVYTCQA-------ENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVT 343
Query: 135 VKCSVADVYPFDRLEIDLLKGDHLMKSQEF----LEDADRKSLETKSLEVTFTPVIEDIG 190
+ C+ + P D L K L++ L A R EV E G
Sbjct: 344 LVCNTPNEAPSD-LRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSG 402
Query: 191 KVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEG 250
V V ++ + V T + V I + V + L GG + + S +
Sbjct: 403 PVSVV---VNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDS 459
Query: 251 LPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRME--DSGIYVCEGVNLIGKNRKEVELIV 308
+P + SG +L L +E DSG Y C N +G ++
Sbjct: 460 DHSPRFSGT-----------SGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDF-- 506
Query: 309 QEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPS--FSWRTQIDSPLSGKVRSEGTNS 366
+ ISP + G +V L+C +P FSW L+G + EG S
Sbjct: 507 HANAARLLISPAAEVVE--GQAVTLSCRSGLSPTPDARFSWY------LNGALLHEGPGS 558
Query: 367 TLTLSPVSFENEHSYLCTVTCGHK---KLEKGIQVELYSFPRDPEIEM-----SGGLVNG 418
+L L S + SY C GH + LY PR P + G G
Sbjct: 559 SLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYP-PRQPTFTTRLDLDAAGAGAG 617
Query: 419 SSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTG 478
+ C+V S P ++LL + ++ T + S S P ++ T
Sbjct: 618 RRGLLLCRVDSDPP---ARLQLLHKDRVVA-------TSLPSGGGCSTCGGCSPRMKVTK 667
Query: 479 KALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAP------RDTTVLVSPSSILEEGSSVNM 532
+ + ++H +E E N + + T + ++PS L+EG+ N+
Sbjct: 668 APNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANL 727
Query: 533 TC----LSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRS 588
TC + G PA W R NG L T+TL+ D+ +Y C + +AG
Sbjct: 728 TCNVSREAAGSPA-NFSWFR---NGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQ 783
Query: 589 RKEVELIIQVTPKD-IKLTAFPSESVKEGDTVIISCTCGNVPETWIIL------------ 635
L+ + P D KL+A + +G + CT + P + L
Sbjct: 784 LSTPVLLSVLYPPDRPKLSAL--LDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLG 841
Query: 636 ---------KKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQ 686
+ KAE L+ +R+ L D+G Y CE+ N +GS SL V+
Sbjct: 842 PQVPSHGRFQAKAEANSLKLE-------VRELGLGDSGSYRCEATNVLGSSNTSLFFQVR 894
Query: 687 G 687
G
Sbjct: 895 G 895
Score = 64.3 bits (155), Expect = 4e-10
Identities = 104/441 (23%), Positives = 165/441 (37%), Gaps = 73/441 (16%)
Query: 283 MEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVM--GC 340
+E+ G+Y+CE N +G Q + P Q G LTC+V
Sbjct: 681 LEEEGLYLCEASNALGNASTSATFNGQATVLAI----APSHTLQEGTEANLTCNVSREAA 736
Query: 341 ESPS-FSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTV-TCGHKKLEKGIQV 398
SP+ FSW +G + ++G T+TL PV+ + Y C + T +L + +
Sbjct: 737 GSPANFSWFR------NGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLL 790
Query: 399 ELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENI-------- 450
+ P P++ + G C V S PL L L GE +L
Sbjct: 791 SVLYPPDRPKLSALLDMGQGHMALFICTVDS-RPLALLA--LFHGEHLLATSLGPQVPSH 847
Query: 451 -EFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNV 509
F + SL+ + E+ + D+G + C+A + S +L+ V
Sbjct: 848 GRFQAKAEANSLKLEVRELG----LGDSG-SYRCEATNVLGS---------SNTSLFFQV 893
Query: 510 APRDTTVLVSPSSILEEGSSVNMTC-LSQGFP-APKILWSRQLPNGELQPLSEN--ATLT 565
R V VSPS L+EG +V ++C + G P W R + QPL E+ ATL
Sbjct: 894 --RGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYR-----DGQPLQESTSATLR 946
Query: 566 LISTKMEDSGVYLCEGINQAGRSRK---EVELIIQVTPKDIKLTAFPSESVKEGDTVIIS 622
+ + +G Y C+ + + L + P+ + LT G ++
Sbjct: 947 FAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTG--PGRLGLLL 1004
Query: 623 CTCGNVPETWIILKKKAETGDTVLKSIDGA-----------------YTIRKAQLKDAGV 665
C + P + L + L+ + G I A L+D GV
Sbjct: 1005 CRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGV 1064
Query: 666 YECESKNKVGSQLRSLTLDVQ 686
Y CE+ N +G S D Q
Sbjct: 1065 YICEASNTLGQASASADFDAQ 1085
Score = 58.2 bits (139), Expect = 3e-08
Identities = 92/422 (21%), Positives = 161/422 (38%), Gaps = 53/422 (12%)
Query: 283 MEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCES 342
+ED G+Y+CE N +G+ + Q V++ PG + G V LTC V
Sbjct: 1059 LEDEGVYICEASNTLGQASASADFDAQA--VNVQVWPGATVRE--GQLVNLTCLVWTTHP 1114
Query: 343 PSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHK--KLEKGIQVEL 400
++ D G+ R + ++ L V+ + SY C V + +L + I +++
Sbjct: 1115 AQLTYTWYQD----GQQRLDA--HSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDV 1168
Query: 401 YSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKS 460
PR+ + G V C V S P ++ L +L + +
Sbjct: 1169 LYAPRNLRLTYLLESHGGQLALVLCTVDSRPPA---QLALSHAGRLLASSTAASVPNTLR 1225
Query: 461 LENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSP 520
LE + P D G C A+ + Q+ +L + + V+++P
Sbjct: 1226 LELRG------PQPRDEG-FYSCSARSPLG---------QANTSLELRL--EGVRVILAP 1267
Query: 521 SSILEEGSSVNMTCLSQGFPAPKI-LWSRQLPNGELQPLSENATLTLISTKMEDSGVYLC 579
+ + EG+ + +TC AP + W NG A+L+ + +G Y C
Sbjct: 1268 EAAVPEGAPITVTCADPAAHAPTLYTWYH---NGRWLQEGPAASLSFLVATRAHAGAYSC 1324
Query: 580 EGINQAG-RSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILK-- 636
+ + G RS + L + P+D L++F + +I CT + P + L
Sbjct: 1325 QAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR--SMAVIQCTVDSEPPAELALSHD 1382
Query: 637 -KKAETGDTVLKSIDGAYTIRKA------QLKDA----GVYECESKNKVGSQLRSLTLDV 685
K T V G ++ A Q++D Y C ++N +GS L V
Sbjct: 1383 GKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQV 1442
Query: 686 QG 687
+G
Sbjct: 1443 EG 1444
Score = 52.8 bits (125), Expect = 1e-06
Identities = 136/632 (21%), Positives = 228/632 (36%), Gaps = 96/632 (15%)
Query: 40 GDSVSLTCSTTGCESPF--FSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTA 97
G +V+L+C + +P FSW LNG + +EG S+L + S + SY C A
Sbjct: 524 GQAVTLSCRSGLSPTPDARFSWY------LNGALLHEGPGSSLLLPAASSTDAGSYHCRA 577
Query: 98 T---CESRKLEKGIQVEIYSFPKDPEIHLSGPLEA-----GKPITVKCSVADVYPFDRLE 149
S + +Y P+ P L+A G+ + C V D P RL+
Sbjct: 578 RDGHSASGPSSPAVLTVLYP-PRQPTFTTRLDLDAAGAGAGRRGLLLCRV-DSDPPARLQ 635
Query: 150 IDLLKGDHLMKSQ-------EFLEDADRKSLETKSLEVT----FTPVIEDIGKVLVCRAK 198
LL D ++ + + TK+ + P++E+ G L C A
Sbjct: 636 --LLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYL-CEAS 692
Query: 199 LHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTC--SSEGLPAPEI 256
+ + T + + TV+++ PS LQEG +TC S E +P
Sbjct: 693 NALGNASTSAT-----------FNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPAN 741
Query: 257 F-WSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTV 315
F W + NG L T+TL+ + D+ +Y C + G L+ P
Sbjct: 742 FSWFR---NGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYP--- 795
Query: 316 EISPGPRIAAQI----GDSVMLTCSV-----------MGCESPSFSWRTQIDSPLSGKVR 360
P+++A + G + C+V G + S Q+ S + +
Sbjct: 796 --PDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAK 853
Query: 361 SEGTNSTLTLSPVSFENEHSYLCTVT--CGHKKLEKGIQVELYSFPRDPEIEMSGGLVNG 418
+E + L + + + SY C T G QV P E L G
Sbjct: 854 AEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPE----LQEG 909
Query: 419 SSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTG 478
+V +SC+V + P G+ + E+ +L
Sbjct: 910 QAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGSAT 969
Query: 479 KALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLV------SPSSI-LEEGSSVN 531
+L LH+ + P R T T ++ P +L+ P+ + L G +
Sbjct: 970 TSLAAPISLHV---SYAP--RHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLV 1024
Query: 532 MTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKE 591
+ L QG P+ P + L + +ED GVY+CE N G++
Sbjct: 1025 ASTL-QGVGGPE----GSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASAS 1079
Query: 592 VELIIQVTPKDIKLTAFPSESVKEGDTVIISC 623
+ Q + + +P +V+EG V ++C
Sbjct: 1080 ADFDAQA----VNVQVWPGATVREGQLVNLTC 1107
Score = 52.0 bits (123), Expect = 2e-06
Identities = 105/455 (23%), Positives = 173/455 (38%), Gaps = 79/455 (17%)
Query: 265 GNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNR----KEVELIVQEKPFTVEISPG 320
GN +H N L L ++ EDSG Y + NR K + V E+P
Sbjct: 91 GNPEHRVCN--LLLKDLQPEDSGSYNFR-FEISEVNRWSDVKGTLVTVTEEPRV------ 141
Query: 321 PRIAAQI----GDSVMLTCS---VMGCESPSFSWRTQIDSPL----SGKVRSEGTNSTLT 369
P IA+ + G V CS V E W+ Q + S K G T
Sbjct: 142 PTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLET 201
Query: 370 LSPVSFENEHSYL--CTVTCGHKKLEKGIQVELYSFPRDPEIEMSGG---LVNGSSVTVS 424
L +H + C ++ + + + I +++ P+ +I +S ++ G VT++
Sbjct: 202 LHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLT 261
Query: 425 CKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQ 484
C+V S YP + +I++L+D L+ K+ + CQ
Sbjct: 262 CQVNSSYP-------------AVSSIKWLKDG--VRLQTKTGVLHLPQAAWSDAGVYTCQ 306
Query: 485 AKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKI 544
A+ + + P +L++ +A V VSP+ + E +V + C + AP
Sbjct: 307 AENGVGSLVSPP------ISLHIFMA----EVQVSPAGPILENQTVTLVCNTPN-EAPSD 355
Query: 545 LWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRK-EVELIIQVTPKDI 603
L N L + + TL L D+G Y CE N G R V +++ P
Sbjct: 356 LRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTP 415
Query: 604 KLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDG------------ 651
LTAF + G I+ C+ + P ++L G +L S G
Sbjct: 416 VLTAF--LETQAGLVGILHCSVVSEPLATLVLSH----GGHILASTSGDSDHSPRFSGTS 469
Query: 652 -----AYTIRKAQLKDAGVYECESKNKVGSQLRSL 681
IR + D+G Y+C + N +G+ +L
Sbjct: 470 GPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTL 504
Score = 49.3 bits (116), Expect = 1e-05
Identities = 68/307 (22%), Positives = 127/307 (41%), Gaps = 48/307 (15%)
Query: 95 CTATCESRKLEKGIQVEIYSFPKDPEIHLSGP---LEAGKPITVKCSVADVYPFDRLEID 151
C + + + + I +++ PK +I LS + G+ +T+ C V YP
Sbjct: 217 CQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYP------- 269
Query: 152 LLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVR 211
+ S ++L+D R L+TK+ + V C+A+ + + S P
Sbjct: 270 ------AVSSIKWLKDGVR--LQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPI-- 319
Query: 212 QAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLS 271
L ++++ + V+P+ + E +VT+ C++ ++ +S ++ L+
Sbjct: 320 ----SLHIFMAE----VQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAH 371
Query: 272 GNATLTLIAMRMEDSGIYVCEGVNLIGKNRK-EVELIVQEKPFTVEISPGPRIAAQIGDS 330
+ TL L D+G Y CE N+ G R V ++V P T ++ + Q G
Sbjct: 372 SH-TLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLT--AFLETQAGLV 428
Query: 331 VMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHK 390
+L CSV + PL+ V S G + L+ S +++HS + T G
Sbjct: 429 GILHCSV-------------VSEPLATLVLSHGGH---ILASTSGDSDHSPRFSGTSGPN 472
Query: 391 KLEKGIQ 397
L I+
Sbjct: 473 SLRLEIR 479
Score = 43.9 bits (102), Expect = 5e-04
Identities = 65/270 (24%), Positives = 111/270 (41%), Gaps = 43/270 (15%)
Query: 38 QIGDSVSLTCSTT--GCESPF-FSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYL 94
Q G +LTC+ + SP FSW NG + +G T+T+ PV+ + Y
Sbjct: 720 QEGTEANLTCNVSREAAGSPANFSWFR------NGVLWAQGPLETVTLLPVARTDAALYA 773
Query: 95 CTATCES-RKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLL 153
C E+ +L + + + P P++ + G C+V D P L L
Sbjct: 774 CRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTV-DSRPLALLA--LF 830
Query: 154 KGDHLMKSQ---------EFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEM 204
G+HL+ + F A+ SL+ + E+ + D G C A +
Sbjct: 831 HGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELG----LGDSGSYR-CEATNVLGSS 885
Query: 205 DSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCS-SEGLPAPEIF-WSKKL 262
++ ++ + + V+PS +LQEG +V ++C G+P + W +
Sbjct: 886 NT-----------SLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYR-- 932
Query: 263 DNGNLQHLSGNATLTLIAMRMEDSGIYVCE 292
D LQ S +ATL A+ + +G Y C+
Sbjct: 933 DGQPLQE-STSATLRFAAITLTQAGAYHCQ 961
Score = 30.8 bits (68), Expect = 4.7
Identities = 26/132 (19%), Positives = 54/132 (40%), Gaps = 16/132 (12%)
Query: 212 QAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIF-WSKKLDNGNLQHL 270
QA L++ + +++ P + EG +T+TC+ AP ++ W NG
Sbjct: 1249 QANTSLELRLEGVRVILA--PEAAVPEGAPITVTCADPAAHAPTLYTW---YHNGRWLQE 1303
Query: 271 SGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEI--SPGPRIAAQIG 328
A+L+ + +G Y C+ + G +P +++ +P + +
Sbjct: 1304 GPAASLSFLVATRAHAGAYSCQAQDAQGTR--------SSRPAALQVLYAPQDAVLSSFR 1355
Query: 329 DSVMLTCSVMGC 340
DS + +V+ C
Sbjct: 1356 DSRARSMAVIQC 1367
>gi|98986445 carcinoembryonic antigen-related cell adhesion molecule
5 preproprotein [Homo sapiens]
Length = 702
Score = 76.3 bits (186), Expect = 1e-13
Identities = 116/506 (22%), Positives = 203/506 (40%), Gaps = 57/506 (11%)
Query: 199 LHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFW 258
LH+ + D V +A + +VY IS N S +++ +V TC E A ++W
Sbjct: 122 LHVIKSDLVN--EEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWW 179
Query: 259 SKKLD---NGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKE-VELIVQEKPFT 314
+ LQ +GN TLTL + D+ Y CE N + R + V L V P
Sbjct: 180 VNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDA 239
Query: 315 VEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVS 374
ISP + + G+++ L+C +SW ++G + + L + ++
Sbjct: 240 PTISP-LNTSYRSGENLNLSCHAASNPPAQYSWF------VNGTFQQ--STQELFIPNIT 290
Query: 375 FENEHSYLCTVTCGHKKLEKG--IQVELYSFPRDPEI--EMSGGLVNGSSVTVSCKVPSV 430
N SY C L + + +Y+ P P I S + + +V ++C+
Sbjct: 291 VNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPE-- 348
Query: 431 YPLDRLEIELLKGETIL--ENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVC--QAK 486
++ T L N + L + L N + +T + + C Q K
Sbjct: 349 ----------IQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNK 398
Query: 487 LHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPS-SILEEGSSVNMTCLSQGFPAPKIL 545
L +D L V P D T +SPS + G +++++C + P +
Sbjct: 399 LSVD--------HSDPVILNVLYGPDDPT--ISPSYTYYRPGVNLSLSCHAASNPPAQYS 448
Query: 546 WSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQA-GRSRKEVELI-IQVTPKDI 603
W L +G +Q ++ ++ I+ K +SG+Y C+ N A G SR V+ I +
Sbjct: 449 W---LIDGNIQQHTQELFISNITEK--NSGLYTCQANNSASGHSRTTVKTITVSAELPKP 503
Query: 604 KLTAFPSESVKEGDTVIISC--TCGNVPETWIILKKKAETGDTV-LKSIDGAYTIRKAQL 660
+++ S+ V++ D V +C N W + + + L + + T+
Sbjct: 504 SISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTR 563
Query: 661 KDAGVYECESKNKVGSQLRS-LTLDV 685
DA Y C +N V + +TLDV
Sbjct: 564 NDARAYVCGIQNSVSANRSDPVTLDV 589
Score = 67.4 bits (163), Expect = 5e-11
Identities = 117/569 (20%), Positives = 208/569 (36%), Gaps = 71/569 (12%)
Query: 41 DSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLC-TATC 99
D+V+ TC ++ + W P++ ++ TLT+ V+ + SY C T
Sbjct: 161 DAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNP 220
Query: 100 ESRKLEKGIQVEIYSFPKDPEIH-LSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHL 158
S + + + + P P I L+ +G+ + + C A P
Sbjct: 221 VSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPP-------------- 266
Query: 159 MKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQ 218
+ F+ ++S + E+ + + C+A R V +
Sbjct: 267 AQYSWFVNGTFQQSTQ----ELFIPNITVNNSGSYTCQA-----HNSDTGLNRTTVTTIT 317
Query: 219 VYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLD---NGNLQHLSGNAT 275
VY P I+ N S +++ +V +TC E ++W + LQ + N T
Sbjct: 318 VYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRT 377
Query: 276 LTLIAMRMEDSGIYVCEGVNLIGKNRKE-VELIVQEKPFTVEISPGPRIAAQIGDSVMLT 334
LTL+++ D G Y C N + + + V L V P ISP + G ++ L+
Sbjct: 378 LTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPS-YTYYRPGVNLSLS 436
Query: 335 CSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTV---TCGHKK 391
C +SW + G ++ L +S ++ +N Y C GH +
Sbjct: 437 CHAASNPPAQYSWL------IDGNIQQH--TQELFISNITEKNSGLYTCQANNSASGHSR 488
Query: 392 LEKGIQVELYSFPRDPEIEMSGG--LVNGSSVTVSCKVPSVYPLDRLEIELLKGETIL-- 447
P+ P I + + + +V +C+ + + T L
Sbjct: 489 TTVKTITVSAELPK-PSISSNNSKPVEDKDAVAFTCEPEA------------QNTTYLWW 535
Query: 448 ENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYV 507
N + L + L N + +T + +A VC + + R TL V
Sbjct: 536 VNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVS------ANRSDPVTLDV 589
Query: 508 NVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLI 567
P DT ++ P S G+++N++C S P+P+ W NG P L +
Sbjct: 590 LYGP-DTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWR---ING--IPQQHTQVLFIA 643
Query: 568 STKMEDSGVYLCEGINQA-GRSRKEVELI 595
++G Y C N A GR+ V+ I
Sbjct: 644 KITPNNNGTYACFVSNLATGRNNSIVKSI 672
Score = 63.9 bits (154), Expect = 5e-10
Identities = 102/471 (21%), Positives = 173/471 (36%), Gaps = 54/471 (11%)
Query: 233 STKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCE 292
+T + G ++ ++C + P + W NG Q L + + + +SG Y C+
Sbjct: 246 NTSYRSGENLNLSCHAASNPPAQYSW---FVNGTFQQ--STQELFIPNITVNNSGSYTCQ 300
Query: 293 GVNL-IGKNRKEVELIV----QEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSW 347
N G NR V I KPF + P + D+V LTC + W
Sbjct: 301 AHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNP---VEDEDAVALTCEPEIQNTTYLWW 357
Query: 348 RTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDP 407
P+S +++ N TLTL V+ + Y C GIQ +L DP
Sbjct: 358 VNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYEC-----------GIQNKLSVDHSDP 406
Query: 408 EIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLE 467
I L T+S P L + +L D +++ + +
Sbjct: 407 VI--LNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQ----QHTQ 460
Query: 468 MTFIPTIEDTGKAL-VCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEE 526
FI I + L CQA + R + +T+ V+ ++ + S +E+
Sbjct: 461 ELFISNITEKNSGLYTCQA-----NNSASGHSRTTVKTITVSAELPKPSISSNNSKPVED 515
Query: 527 GSSVNMTCLSQGFPAPKILW--SRQLP-NGELQPLSENATLTLISTKMEDSGVYLCEGIN 583
+V TC + + W + LP + LQ + N TLTL + D+ Y+C N
Sbjct: 516 KDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQN 575
Query: 584 QAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPE---TWIILKKKAE 640
+R + + + D + + P S G + +SC + P +W I
Sbjct: 576 SVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRI------ 629
Query: 641 TGDTVLKSIDGAYTIRKAQLKDAGVYECESKN----KVGSQLRSLTLDVQG 687
+ + + I K + G Y C N + S ++S+T+ G
Sbjct: 630 --NGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASG 678
Score = 30.4 bits (67), Expect = 6.2
Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 14/88 (15%)
Query: 27 IETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVS 86
I + P+S YL+ G +++L+C + SP +SWR +NG + T L + ++
Sbjct: 597 IISPPDSSYLS--GANLNLSCHSASNPSPQYSWR------ING--IPQQHTQVLFIAKIT 646
Query: 87 FGNEHSYLC----TATCESRKLEKGIQV 110
N +Y C AT + + K I V
Sbjct: 647 PNNNGTYACFVSNLATGRNNSIVKSITV 674
>gi|4827022 contactin 2 precursor [Homo sapiens]
Length = 1040
Score = 74.7 bits (182), Expect = 3e-13
Identities = 85/378 (22%), Positives = 154/378 (40%), Gaps = 39/378 (10%)
Query: 239 GGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIG 298
G VT+ C + G P P I W K + + Q + TL + ++ ED G Y CE N G
Sbjct: 254 GQQVTLECFAFGNPVPRIKWRKVDGSLSPQWTTAEPTLQIPSVSFEDEGTYECEAENSKG 313
Query: 299 KNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGK 358
++ + +IVQ +P +++ A IG ++ C+ G P+ W + PL+ +
Sbjct: 314 RDTVQGRIIVQAQPEWLKVISDTE--ADIGSNLRWGCAAAGKPRPTVRW-LRNGEPLASQ 370
Query: 359 VRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLV-- 416
R E L S +S E+ Y C H + ++ + + D + L+
Sbjct: 371 NRVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPA 430
Query: 417 -NGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIE 475
G + + C+ P P + + KG IL N + T +L +++ +
Sbjct: 431 ARGGEILIPCQ-PRAAP--KAVVLWSKGTEILVNSSRVTVTPDGTLIIRNISRS------ 481
Query: 476 DTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSI-LEEGSSVNMTC 534
D GK C A+ + + ST L V A T + ++PSS + G ++ + C
Sbjct: 482 DEGK-YTCFAENFMG-------KANSTGILSVRDA---TKITLAPSSADINLGDNLTLQC 530
Query: 535 LSQGFPAPKILWSRQL---------PNGELQPLSENAT---LTLISTKMEDSGVYLCEGI 582
+ P + ++ L P G + + T LT+++ ++ G Y C
Sbjct: 531 HASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQ 590
Query: 583 NQAGRSRKEVELIIQVTP 600
+ KE ++++ P
Sbjct: 591 TVVDSASKEATVLVRGPP 608
Score = 74.3 bits (181), Expect = 4e-13
Identities = 91/382 (23%), Positives = 146/382 (38%), Gaps = 47/382 (12%)
Query: 329 DSVMLTCSVMGCESPSFSWR---TQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLC-- 383
+ V+L C ++ W+ T++ + + G N + ++P ++ Y C
Sbjct: 55 EQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVI-MNPTKAQDAGVYQCLA 113
Query: 384 -----TVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEI 438
TV L G E RDP G V + C P+ YP
Sbjct: 114 SNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGW-----GVMLPCNPPAHYPG----- 163
Query: 439 ELLKGETILENIEFLEDTDMKSLENKSLEMTFIP--TIEDTGKALVCQAKLHIDDMEFEP 496
L +L TD + +++ +I D G C A H+D F
Sbjct: 164 --LSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGN-YSCLATSHMD---FST 217
Query: 497 KQRQSTQTLYVNVAPRDTTVLVSPS--------SILEEGSSVNMTCLSQGFPAPKILWSR 548
K S + +N+A DT L +PS + G V + C + G P P+I W +
Sbjct: 218 KSVFS-KFAQLNLAAEDTR-LFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRK 275
Query: 549 QLPNGELQPLSENA--TLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLT 606
+G L P A TL + S ED G Y CE N GR + +I+Q P+ +K+
Sbjct: 276 V--DGSLSPQWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQPEWLKVI 333
Query: 607 AFPSESVKEGDTVIISCTCGNVPETWIILKKKAE--TGDTVLKSIDGAYTIRKAQLKDAG 664
+ + G + C P + + E ++ + G K L+D+G
Sbjct: 334 SDTEADI--GSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLAGDLRFSKLSLEDSG 391
Query: 665 VYECESKNKVGSQLRSLTLDVQ 686
+Y+C ++NK G+ S L VQ
Sbjct: 392 MYQCVAENKHGTIYASAELAVQ 413
Score = 69.7 bits (169), Expect = 9e-12
Identities = 100/463 (21%), Positives = 178/463 (38%), Gaps = 53/463 (11%)
Query: 242 VTMTCSSEGLPAPEIFWSK-----KLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNL 296
V + C + P W KL+ G+ L G + + + +D+G+Y C N
Sbjct: 57 VLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQCLASNP 116
Query: 297 IGKNRKEVELIVQEKPFTVEISPGPR--IAAQIGDSVMLTCSVMGCESPSFSWRTQIDS- 353
+G ++ F E S R + A G VML C+ P S+R ++
Sbjct: 117 VGTVVSREAIL--RFGFLQEFSKEERDPVKAHEGWGVMLPCNPPA-HYPGLSYRWLLNEF 173
Query: 354 ----PLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEI 409
P G+ T L ++ + + +Y C T K + F + ++
Sbjct: 174 PNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSV------FSKFAQL 227
Query: 410 EMSGGLVNGSSVTVSCKVPS-VYPL--DRLEIELLKGETILENIEFLEDTDMKSLENKSL 466
++ + ++ + P+ Y L ++ +E + I++ + S + +
Sbjct: 228 NLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWTTA 287
Query: 467 EMTF-IPTI--EDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSI 523
E T IP++ ED G C+A+ K R + Q + A + ++S +
Sbjct: 288 EPTLQIPSVSFEDEG-TYECEAE--------NSKGRDTVQGRIIVQAQPEWLKVISDTEA 338
Query: 524 LEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLIS-------TKMEDSGV 576
+ GS++ C + G P P + W R NGE PL+ + +++ +EDSG+
Sbjct: 339 -DIGSNLRWGCAAAGKPRPTVRWLR---NGE--PLASQNRVEVLAGDLRFSKLSLEDSGM 392
Query: 577 YLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPS-ESVKEGDTVIISCTCGNVPETWIIL 635
Y C N+ G EL +Q D +L G ++I C P+ ++
Sbjct: 393 YQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLW 452
Query: 636 KKKAE---TGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVG 675
K E V + DG IR D G Y C ++N +G
Sbjct: 453 SKGTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMG 495
Score = 62.0 bits (149), Expect = 2e-09
Identities = 92/392 (23%), Positives = 149/392 (38%), Gaps = 65/392 (16%)
Query: 325 AQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCT 384
A +G V L C G P WR ++D LS + + TL + VSFE+E +Y C
Sbjct: 251 ALVGQQVTLECFAFGNPVPRIKWR-KVDGSLSPQWTT--AEPTLQIPSVSFEDEGTYECE 307
Query: 385 V--TCGHKKLEKGI----QVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLE- 437
+ G ++ I Q E D E ++ L G + + P+V L E
Sbjct: 308 AENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPR-PTVRWLRNGEP 366
Query: 438 ------IELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDD 491
+E+L G+ + LED+ M ++ T + E +AL D
Sbjct: 367 LASQNRVEVLAGDLRFSKLS-LEDSGMYQCVAENKHGTIYASAELAVQALA-------PD 418
Query: 492 MEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQ-- 549
P +R + P++ G + + C + P +LWS+
Sbjct: 419 FRLNPVRR------------------LIPAA---RGGEILIPCQPRAAPKAVVLWSKGTE 457
Query: 550 -LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAF 608
L N ++ + TL + + D G Y C N G++ L ++ K +T
Sbjct: 458 ILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATK---ITLA 514
Query: 609 PSES-VKEGDTVIISCTCGNVPE-----TWIIL-------KKKAETGDTVLKSIDGAYTI 655
PS + + GD + + C + P TW + K T +K G TI
Sbjct: 515 PSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTI 574
Query: 656 RKAQLKDAGVYECESKNKVGSQLRSLTLDVQG 687
AQL+ G Y C ++ V S + T+ V+G
Sbjct: 575 LNAQLRHGGKYTCMAQTVVDSASKEATVLVRG 606
Score = 50.4 bits (119), Expect = 6e-06
Identities = 69/307 (22%), Positives = 122/307 (39%), Gaps = 35/307 (11%)
Query: 37 AQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTS--TLTMNPVSFGNEHSYL 94
A +G V+L C G P WR ++G ++ + TT+ TL + VSF +E +Y
Sbjct: 251 ALVGQQVTLECFAFGNPVPRIKWR-----KVDGSLSPQWTTAEPTLQIPSVSFEDEGTYE 305
Query: 95 CTA-TCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLL 153
C A + R +G ++ + + P+ ++ + G + C+ A R + L
Sbjct: 306 CEAENSKGRDTVQG-RIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGK---PRPTVRWL 361
Query: 154 KGDHLMKSQEFLEDADRKSLETKSLEVTFTPV-IEDIGKVLVCRAKLHIDEMDSVPTVRQ 212
+ + SQ +E + ++ F+ + +ED G H S Q
Sbjct: 362 RNGEPLASQ--------NRVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQ 413
Query: 213 AVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK---LDNGNLQH 269
A ++P + V GG + + C P + WSK L N +
Sbjct: 414 A-------LAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGTEILVNSSRVT 466
Query: 270 LSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIA-AQIG 328
++ + TL + + D G Y C N +GK L V++ +I+ P A +G
Sbjct: 467 VTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRD---ATKITLAPSSADINLG 523
Query: 329 DSVMLTC 335
D++ L C
Sbjct: 524 DNLTLQC 530
Score = 45.8 bits (107), Expect = 1e-04
Identities = 36/161 (22%), Positives = 64/161 (39%), Gaps = 7/161 (4%)
Query: 228 ISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKK----LDNGNLQHLSGNATLTLIAMRM 283
+ V T+ G ++ C++ G P P + W + ++ L+G+ L + +
Sbjct: 330 LKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLAGD--LRFSKLSL 387
Query: 284 EDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPR-IAAQIGDSVMLTCSVMGCES 342
EDSG+Y C N G EL VQ ++P R I A G +++ C
Sbjct: 388 EDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPK 447
Query: 343 PSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLC 383
W + ++ + + TL + +S +E Y C
Sbjct: 448 AVVLWSKGTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTC 488
>gi|7657361 contactin 6 [Homo sapiens]
Length = 1028
Score = 73.2 bits (178), Expect = 8e-13
Identities = 93/396 (23%), Positives = 153/396 (38%), Gaps = 51/396 (12%)
Query: 315 VEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVS 374
+E+ I A SV L C +G P SWR SPL GKV+ + + L +
Sbjct: 229 IEVRFPETIQAAKDSSVKLECFALGNPVPDISWRRLDGSPLPGKVKYSKSQAILEIPNFQ 288
Query: 375 FENEHSYLCTVT-CGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPL 433
E+E Y C + + L KG Q+ Y+ P + + L ++ CK
Sbjct: 289 QEDEGFYECIASNLRGRNLAKG-QLIFYAPPEWEQKIQNTHLSIYDNLLWECKASG---- 343
Query: 434 DRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDME 493
+ T L+N E L + +EN +L +T + + D+G C A+
Sbjct: 344 -----KPNPWYTWLKNGERLNPEERIQIENGTLIITML-NVSDSG-VYQCAAE------- 389
Query: 494 FEPKQRQSTQTLYVNV-------APRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILW 546
Q +Y N AP + V S ++ G + + C FP I W
Sbjct: 390 ------NKYQIIYANAELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISW 443
Query: 547 SR---QLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDI 603
R L + L E+ +L + + D+G Y C NQ G ++ LI++ +
Sbjct: 444 KRGTETLRQSKRIFLLEDGSLKIYNITRSDAGSYTCIATNQFGTAKNTGSLIVK---ERT 500
Query: 604 KLTAFPSE-SVKEGDTVIISCTCGNVPETWII-----------LKKKAETGDTVLKSIDG 651
+T PS+ V G+++++ C + P ++ LKK + + G
Sbjct: 501 VITVPPSKMDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESVG 560
Query: 652 AYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQG 687
IR QL +G Y C + + S + V+G
Sbjct: 561 DLMIRNIQLHHSGKYLCTVQTTLESLSAVADIIVRG 596
Score = 66.6 bits (161), Expect = 8e-11
Identities = 106/504 (21%), Positives = 199/504 (39%), Gaps = 63/504 (12%)
Query: 242 VTMTCSSEGLPAPEIFWSKK---LDNGNLQH--LSGNATLTLIAMRMEDSGIYVCEGVNL 296
V + C++ G P+P W + +D H L G + +D G+Y C NL
Sbjct: 46 VILNCAANGYPSPHYRWKQNGTDIDFTMSYHYRLDGGSLAINSPHTDQDIGMYQCLATNL 105
Query: 297 IGK--NRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESP-SFSWRTQIDS 353
+G +RK + F E ++ + G V+L C S++W T D+
Sbjct: 106 LGTILSRKAKLQFAYIEDF--ETKTRSTVSVREGQGVVLLCGPPPHFGDLSYAW-TFNDN 162
Query: 354 PL-----SGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPE 408
PL + + S+ T + L ++ V + +Y C +T +K+ ++ +Q P P
Sbjct: 163 PLYVQEDNRRFVSQETGN-LYIAKVEPSDVGNYTCFIT--NKEAQRSVQG-----PPTPL 214
Query: 409 IEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEM 468
++ + G++ + + P I+ K ++ F + + + L+
Sbjct: 215 VQRTDGVMGEYEPKIEVRFPET-------IQAAKDSSVKLEC-FALGNPVPDISWRRLDG 266
Query: 469 TFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTT----VLVSPSSIL 524
+ +P GK +++ ++ F+ + + + N+ R+ + +P
Sbjct: 267 SPLP-----GKVKYSKSQAILEIPNFQQEDEGFYECIASNLRGRNLAKGQLIFYAPPEWE 321
Query: 525 EEGSSVNMT--------CLSQGFPAPKILWSRQLPNGE-LQPLS----ENATLTLISTKM 571
++ + +++ C + G P P W L NGE L P EN TL + +
Sbjct: 322 QKIQNTHLSIYDNLLWECKASGKPNPWYTW---LKNGERLNPEERIQIENGTLIITMLNV 378
Query: 572 EDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSES-VKEGDTVIISCTCGNVPE 630
DSGVY C N+ EL + + D + +S V+ G ++I C P
Sbjct: 379 SDSGVYQCAAENKYQIIYANAELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPR 438
Query: 631 TWIILKKKAET---GDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQG 687
I K+ ET + DG+ I DAG Y C + N+ G+ + +L V
Sbjct: 439 AAISWKRGTETLRQSKRIFLLEDGSLKIYNITRSDAGSYTCIATNQFGTAKNTGSLIV-- 496
Query: 688 RENNKDYFSPELLVLYFASSLIIP 711
+E P + + S+++P
Sbjct: 497 KERTVITVPPSKMDVTVGESIVLP 520
Score = 66.2 bits (160), Expect = 1e-10
Identities = 100/402 (24%), Positives = 151/402 (37%), Gaps = 46/402 (11%)
Query: 26 KIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPV 85
KIE A SV L C G P SWR SPL GKV + + L +
Sbjct: 228 KIEVRFPETIQAAKDSSVKLECFALGNPVPDISWRRLDGSPLPGKVKYSKSQAILEIPNF 287
Query: 86 SFGNEHSYLCTAT-CESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADV-- 142
+E Y C A+ R L KG Q+ Y+ P+ + + L + +C +
Sbjct: 288 QQEDEGFYECIASNLRGRNLAKG-QLIFYAPPEWEQKIQNTHLSIYDNLLWECKASGKPN 346
Query: 143 --YPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLH 200
Y + +K+ E L +R +E +L +T V D G V C A
Sbjct: 347 PWYTW-------------LKNGERLNPEERIQIENGTLIITMLNV-SDSG-VYQCAA--- 388
Query: 201 IDEMDSVPTVRQAVKELQVYIS-PKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWS 259
++ + A EL+V S P + V + +Q GG + + C P I W
Sbjct: 389 ----ENKYQIIYANAELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISWK 444
Query: 260 K---KLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVE 316
+ L L + +L + + D+G Y C N G + LIV+E+ TV
Sbjct: 445 RGTETLRQSKRIFLLEDGSLKIYNITRSDAGSYTCIATNQFGTAKNTGSLIVKER--TVI 502
Query: 317 ISPGPRIAAQIGDSVMLTCSVMGCESPS----FSW--RTQIDSPLSGKVRSE--GTNST- 367
P ++ +G+S++L C V PS F W + G E G S
Sbjct: 503 TVPPSKMDVTVGESIVLPCQV--SHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESVG 560
Query: 368 -LTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPE 408
L + + + YLCTV + L + + P PE
Sbjct: 561 DLMIRNIQLHHSGKYLCTVQTTLESLSAVADIIVRGPPGPPE 602
Score = 60.1 bits (144), Expect = 7e-09
Identities = 54/230 (23%), Positives = 103/230 (44%), Gaps = 19/230 (8%)
Query: 241 SVTMTCSSEGLPAPEIFWSKKLDN----GNLQHLSGNATLTLIAMRMEDSGIYVCEGVNL 296
SV + C + G P P+I W ++LD G +++ A L + + ED G Y C NL
Sbjct: 244 SVKLECFALGNPVPDISW-RRLDGSPLPGKVKYSKSQAILEIPNFQQEDEGFYECIASNL 302
Query: 297 IGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLS 356
G+N + +LI P + ++ I D+++ C G +P ++W + L+
Sbjct: 303 RGRNLAKGQLIFYAPPEWEQKIQNTHLS--IYDNLLWECKASGKPNPWYTW-LKNGERLN 359
Query: 357 GKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYS----FPRDPEIEMS 412
+ R + N TL ++ ++ + Y C ++ + ++ + + F + P ++
Sbjct: 360 PEERIQIENGTLIITMLNVSDSGVYQCAAENKYQIIYANAELRVLASAPDFSKSP-VKKK 418
Query: 413 GGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETIL---ENIEFLEDTDMK 459
+ G + + CK P+ +P R I +G L + I LED +K
Sbjct: 419 SFVQVGGDIVIGCK-PNAFP--RAAISWKRGTETLRQSKRIFLLEDGSLK 465
Score = 33.1 bits (74), Expect = 0.95
Identities = 36/166 (21%), Positives = 56/166 (33%), Gaps = 28/166 (16%)
Query: 528 SSVNMTCLSQGFPAPKILWSR-------------QLPNGELQPLSENATLTLISTKMEDS 574
S V + C + G+P+P W + +L G L S + +D
Sbjct: 44 SEVILNCAANGYPSPHYRWKQNGTDIDFTMSYHYRLDGGSLAINSPHTD--------QDI 95
Query: 575 GVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISC----TCGNVPE 630
G+Y C N G + +D + + SV+EG V++ C G++
Sbjct: 96 GMYQCLATNLLGTILSRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLCGPPPHFGDLSY 155
Query: 631 TWIILKKK---AETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNK 673
W E + G I K + D G Y C NK
Sbjct: 156 AWTFNDNPLYVQEDNRRFVSQETGNLYIAKVEPSDVGNYTCFITNK 201
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.132 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,499,364
Number of Sequences: 37866
Number of extensions: 1315639
Number of successful extensions: 8103
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 176
Number of HSP's successfully gapped in prelim test: 249
Number of HSP's that attempted gapping in prelim test: 3050
Number of HSP's gapped (non-prelim): 3086
length of query: 739
length of database: 18,247,518
effective HSP length: 110
effective length of query: 629
effective length of database: 14,082,258
effective search space: 8857740282
effective search space used: 8857740282
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.