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Search of human proteins with 4507537
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4507537 nuclear receptor subfamily 2, group E, member 1
[Homo sapiens]
(385 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4507537 nuclear receptor subfamily 2, group E, member 1 [Homo... 774 0.0
gi|7657395 photoreceptor-specific nuclear receptor isoform b [Ho... 304 1e-82
gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo... 261 1e-69
gi|14149746 nuclear receptor subfamily 2, group F, member 2 isof... 254 9e-68
gi|7706515 photoreceptor-specific nuclear receptor isoform a [Ho... 251 1e-66
gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Hom... 246 2e-65
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 215 6e-56
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens] 210 2e-54
gi|11415052 retinoid X receptor, beta [Homo sapiens] 206 3e-53
gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens] 184 2e-46
gi|31077209 hepatocyte nuclear factor 4 alpha isoform c [Homo sa... 177 1e-44
gi|31077207 hepatocyte nuclear factor 4 alpha isoform a [Homo sa... 177 1e-44
gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo sa... 177 1e-44
gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo sa... 177 1e-44
gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo sa... 177 1e-44
gi|71725339 hepatocyte nuclear factor 4 alpha isoform d [Homo sa... 177 1e-44
gi|238550159 estrogen-related receptor beta [Homo sapiens] 165 7e-41
gi|45545429 estrogen-related receptor gamma isoform 2 [Homo sapi... 164 2e-40
gi|45545427 estrogen-related receptor gamma isoform 2 [Homo sapi... 164 2e-40
gi|45545433 estrogen-related receptor gamma isoform 1 [Homo sapi... 164 2e-40
gi|197209821 estrogen-related receptor gamma isoform 2 [Homo sap... 164 2e-40
gi|223555953 nuclear receptor subfamily 2, group F, member 2 iso... 159 3e-39
gi|223555951 nuclear receptor subfamily 2, group F, member 2 iso... 159 3e-39
gi|223555949 nuclear receptor subfamily 2, group F, member 2 iso... 159 3e-39
gi|170295804 estrogen receptor alpha isoform 4 [Homo sapiens] 155 4e-38
gi|170295802 estrogen receptor alpha isoform 3 [Homo sapiens] 155 4e-38
gi|170295800 estrogen receptor alpha isoform 2 [Homo sapiens] 155 4e-38
gi|62821794 estrogen receptor alpha isoform 1 [Homo sapiens] 155 4e-38
gi|10835013 estrogen receptor beta isoform 1 [Homo sapiens] 149 5e-36
gi|18860920 estrogen-related receptor alpha [Homo sapiens] 147 2e-35
>gi|4507537 nuclear receptor subfamily 2, group E, member 1 [Homo
sapiens]
Length = 385
Score = 774 bits (1999), Expect = 0.0
Identities = 385/385 (100%), Positives = 385/385 (100%)
Query: 1 MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGC 60
MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGC
Sbjct: 1 MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGC 60
Query: 61 PVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHF 120
PVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHF
Sbjct: 61 PVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHF 120
Query: 121 PSAALPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEV 180
PSAALPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEV
Sbjct: 121 PSAALPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEV 180
Query: 181 ATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDAN 240
ATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDAN
Sbjct: 181 ATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDAN 240
Query: 241 TLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTH 300
TLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTH
Sbjct: 241 TLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTH 300
Query: 301 SGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEE 360
SGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEE
Sbjct: 301 SGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEE 360
Query: 361 VFFKKTIGNVPITRLLSDMYKSSDI 385
VFFKKTIGNVPITRLLSDMYKSSDI
Sbjct: 361 VFFKKTIGNVPITRLLSDMYKSSDI 385
>gi|7657395 photoreceptor-specific nuclear receptor isoform b [Homo
sapiens]
Length = 410
Score = 304 bits (778), Expect = 1e-82
Identities = 164/377 (43%), Positives = 231/377 (61%), Gaps = 19/377 (5%)
Query: 14 IPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRAC 73
+ C+VCGD SSGKHYG+YAC+GCSGFFKRS+RR Y C+ G G CPVDK HRNQC+AC
Sbjct: 45 LQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVG-AGMCPVDKAHRNQCQAC 103
Query: 74 RLKKCLEVNMNKDAVQHERGPR-TSTIRKQVALYFRGHKEENGAAAHFPSAALP-APAFF 131
RLKKCL+ MN+DAVQ+ER PR T+ + + E+ A P+ P P
Sbjct: 104 RLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPM 163
Query: 132 TAVTQLEPHGL------ELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESV 185
+A L H + E A + + + P++P + +S+
Sbjct: 164 SAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSS---PCGLDSI 220
Query: 186 CESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAV 245
E++ARLLFM++KWAK++P FS+L +DQ++LLE+AW ELF+LG QW++P+D+ LLA
Sbjct: 221 HETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAP 280
Query: 246 SGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSEL 305
+ +L E + LQE ++RFR L +D TEFAC+K +V FK E
Sbjct: 281 PEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFK-------PET 333
Query: 306 RSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKK 365
R ++ + ALQD++Q+ L+ + +P+QP RFGKLLLLLP+LR I+ IE +FF+K
Sbjct: 334 RGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRK 393
Query: 366 TIGNVPITRLLSDMYKS 382
TIGN P+ +LL DM+K+
Sbjct: 394 TIGNTPMEKLLCDMFKN 410
>gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo
sapiens]
Length = 423
Score = 261 bits (666), Expect = 1e-69
Identities = 147/389 (37%), Positives = 212/389 (54%), Gaps = 63/389 (16%)
Query: 4 PAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVD 63
P GS I C VCGD+SSGKHYG + C+GC FFKRS+RRN TY C++ CP+D
Sbjct: 74 PPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRN--CPID 131
Query: 64 KTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALY----FRGHKEENGAAAH 119
+ HRNQC+ CRLKKCL+V M ++AVQ R P T Q AL GH +G
Sbjct: 132 QHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLNGHCYLSG---- 187
Query: 120 FPSAALPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKY------PHEVNGT 173
+ + + + EP+ PT +Y P+ + G
Sbjct: 188 ----------YISLLLRAEPY---------------------PTSRYGSQCMQPNNIMGI 216
Query: 174 PMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQW 233
E++CE AARLLF +++WA+++P F L + DQ+ LL W ELFVL AQ
Sbjct: 217 ---------ENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQC 267
Query: 234 AIPVDANTLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVT 293
++P+ LLA +G++ + ++ + I+ QE V + + L +D+ E++CLK IV
Sbjct: 268 SMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVL 327
Query: 294 FKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSI 353
F S+ +AA I +LQ+++Q L Y+ ++YP QP RFGKLLL LP+LR++
Sbjct: 328 FT-------SDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTV 380
Query: 354 SPSTIEEVFFKKTIGNVPITRLLSDMYKS 382
S S IE++FF + +G PI L+ DM S
Sbjct: 381 SSSVIEQLFFVRLVGKTPIETLIRDMLLS 409
>gi|14149746 nuclear receptor subfamily 2, group F, member 2 isoform
a [Homo sapiens]
Length = 414
Score = 254 bits (649), Expect = 9e-68
Identities = 139/375 (37%), Positives = 208/375 (55%), Gaps = 55/375 (14%)
Query: 14 IPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRAC 73
I C VCGD+SSGKHYG + C+GC FFKRS+RRN +Y C++ CP+D+ HRNQC+ C
Sbjct: 77 IECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRN--CPIDQHHRNQCQYC 134
Query: 74 RLKKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTA 133
RLKKCL+V M ++AVQ R P T Q AL NG + S + +
Sbjct: 135 RLKKCLKVGMRREAVQRGRMPPTQPTHGQFAL-------TNGDPLNCHSYL---SGYISL 184
Query: 134 VTQLEPHGLELAAVSTTPERQTLVSLAQPTPKY------PHEVNGTPMYLYEVATESVCE 187
+ + EP+ PT ++ P+ + G E++CE
Sbjct: 185 LLRAEPY---------------------PTSRFGSQCMQPNNIMGI---------ENICE 214
Query: 188 SAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSG 247
AAR+LF +++WA+++P F L + DQ+ LL W ELFVL AQ ++P+ LLA +G
Sbjct: 215 LAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAG 274
Query: 248 MNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRS 307
++ + ++ + I+ QE V + + L +D+ E++CLK IV F S+
Sbjct: 275 LHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFT-------SDACG 327
Query: 308 FRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTI 367
+ A + +LQ+++Q L Y+ ++YP QP RFGKLLL LP+LR++S S IE++FF + +
Sbjct: 328 LSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLV 387
Query: 368 GNVPITRLLSDMYKS 382
G PI L+ DM S
Sbjct: 388 GKTPIETLIRDMLLS 402
>gi|7706515 photoreceptor-specific nuclear receptor isoform a [Homo
sapiens]
Length = 367
Score = 251 bits (640), Expect = 1e-66
Identities = 137/334 (41%), Positives = 196/334 (58%), Gaps = 19/334 (5%)
Query: 14 IPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRAC 73
+ C+VCGD SSGKHYG+YAC+GCSGFFKRS+RR Y C+ G G CPVDK HRNQC+AC
Sbjct: 45 LQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVG-AGMCPVDKAHRNQCQAC 103
Query: 74 RLKKCLEVNMNKDAVQHERGPR-TSTIRKQVALYFRGHKEENGAAAHFPSAALP-APAFF 131
RLKKCL+ MN+DAVQ+ER PR T+ + + E+ A P+ P P
Sbjct: 104 RLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPM 163
Query: 132 TAVTQLEPHGL------ELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESV 185
+A L H + E A + + + P++P + +S+
Sbjct: 164 SAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSS---PCGLDSI 220
Query: 186 CESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAV 245
E++ARLLFM++KWAK++P FS+L +DQ++LLE+AW ELF+LG QW++P+D+ LLA
Sbjct: 221 HETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAP 280
Query: 246 SGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSEL 305
+ +L E + LQE ++RFR L +D TEFAC+K +V FK E
Sbjct: 281 PEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFK-------PET 333
Query: 306 RSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCR 339
R ++ + ALQD++Q+ L+ + +P+QP R
Sbjct: 334 RGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVR 367
>gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Homo
sapiens]
Length = 404
Score = 246 bits (629), Expect = 2e-65
Identities = 144/382 (37%), Positives = 206/382 (53%), Gaps = 52/382 (13%)
Query: 12 LDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCR 71
L + C VCGD+SSGKHYGV+ C+GC FFKRSIRRN +Y C+S C +D+ HRNQC+
Sbjct: 52 LQVDCVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRD--CQIDQHHRNQCQ 109
Query: 72 ACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFF 131
CRLKKC V M K+AVQ R P + P A
Sbjct: 110 YCRLKKCFRVGMRKEAVQRGRIPHS-----------------------LPGAV------- 139
Query: 132 TAVTQLEPHGLELAAVST-------TPERQTLVSLAQPTPKYPHEVN----GTPMYLYEV 180
A + P G LAAV++ P + + L + P YP G +
Sbjct: 140 -AASSGSPPGSALAAVASGGDLFPGQPVSELIAQLLRAEP-YPAAAGRFGAGGGAAGAVL 197
Query: 181 ATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDAN 240
++VCE AARLLF +++WA+ P F L + DQ+ LL +W ELFVL AQ A+P+
Sbjct: 198 GIDNVCELAARLLFSTVEWARHAPFFPELPVADQVALLRLSWSELFVLNAAQAALPLHTA 257
Query: 241 TLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTH 300
LLA +G++ +++ + +++A QE V + +L++D+ E+ CLK I F P
Sbjct: 258 PLLAAAGLHAAPMAAERAVAFMDQVRAFQEQVDKLGRLQVDSAEYGCLKAIALF--TPDA 315
Query: 301 SGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEE 360
G + A + +LQ++AQ+ L Y+ +YP+QP RFG+LLL LPALR++ S I +
Sbjct: 316 CG-----LSDPAHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQ 370
Query: 361 VFFKKTIGNVPITRLLSDMYKS 382
+FF + +G PI L+ DM S
Sbjct: 371 LFFMRLVGKTPIETLIRDMLLS 392
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 215 bits (547), Expect = 6e-56
Identities = 130/383 (33%), Positives = 196/383 (51%), Gaps = 52/383 (13%)
Query: 4 PAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVD 63
P+G+ + C +CGDRSSGKHYGVY+C+GC GFFKR++R++ TY C+ C +D
Sbjct: 123 PSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKD--CLID 180
Query: 64 KTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSA 123
K RN+C+ CR +KCL + M ++AVQ ER RG K+ N S+
Sbjct: 181 KRQRNRCQYCRYQKCLAMGMKREAVQEERQ--------------RG-KDRNENEVESTSS 225
Query: 124 A---LPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEV 180
A +P A +EP T + + L +P P
Sbjct: 226 ANEDMPVERILEAELAVEP--------KTETYVEANMGLNPSSPNDP------------- 264
Query: 181 ATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDAN 240
++C++A + LF ++WAK +P FS L L DQ++LL W EL + + +I V
Sbjct: 265 -VTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDG 323
Query: 241 TLLAVS-GMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPT 299
LLA ++ ++ S + I + L E+V++ R +++D TE CL+ IV F
Sbjct: 324 ILLATGLHVHRNSAHSAGVGAIFDRV--LTELVSKMRDMQMDKTELGCLRAIVLFNP--- 378
Query: 300 HSGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIE 359
+ + N A + AL+++ +L +Y +YP QP RF KLLL LPALRSI +E
Sbjct: 379 ----DSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLE 434
Query: 360 EVFFKKTIGNVPITRLLSDMYKS 382
+FF K IG+ PI L +M ++
Sbjct: 435 HLFFFKLIGDTPIDTFLMEMLEA 457
>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
Length = 463
Score = 210 bits (534), Expect = 2e-54
Identities = 120/383 (31%), Positives = 190/383 (49%), Gaps = 49/383 (12%)
Query: 1 MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGC 60
M+ P+ S ++ C +CGDRSSGKHYGVY+C+GC GFFKR+IR++ Y C+ C
Sbjct: 124 MNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKD--C 181
Query: 61 PVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHF 120
+DK RN+C+ CR +KCL + M ++AVQ ER + GH++
Sbjct: 182 LIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHED-------- 233
Query: 121 PSAALPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEV 180
+P A +EP ++ V+
Sbjct: 234 ----MPVERILEAELAVEPKTESYGDMNMENSTNDPVT---------------------- 267
Query: 181 ATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDAN 240
++C +A + LF ++WAK +P FS L+L+DQ++LL W EL + + ++ V
Sbjct: 268 ---NICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDG 324
Query: 241 TLLAVS-GMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPT 299
LLA ++ + S + I + L E+V++ + +++D +E CL+ IV F
Sbjct: 325 ILLATGLHVHRSSAHSAGVGSIFDRV--LTELVSKMKDMQMDKSELGCLRAIVLFNP--- 379
Query: 300 HSGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIE 359
+ + N + + L+++ TL +Y +YP QP RF KLLL LPALRSI +E
Sbjct: 380 ----DAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLE 435
Query: 360 EVFFKKTIGNVPITRLLSDMYKS 382
+FF K IG+ PI L +M ++
Sbjct: 436 HLFFFKLIGDTPIDTFLMEMLET 458
>gi|11415052 retinoid X receptor, beta [Homo sapiens]
Length = 533
Score = 206 bits (524), Expect = 3e-53
Identities = 127/372 (34%), Positives = 188/372 (50%), Gaps = 53/372 (14%)
Query: 16 CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRL 75
C +CGDRSSGKHYGVY+C+GC GFFKR+IR++ TY C+ C VDK RN+C+ CR
Sbjct: 205 CAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKD--CTVDKRQRNRCQYCRY 262
Query: 76 KKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGH-KEENGAAAHFPSAALPAPAFFTA- 133
+KCL M ++AVQ ER RG K+ +G A +P A
Sbjct: 263 QKCLATGMKREAVQEERQ--------------RGKDKDGDGEGAGGAPEEMPVDRILEAE 308
Query: 134 --VTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAAR 191
V Q G+E P G+ + T ++C++A +
Sbjct: 309 LAVEQKSDQGVE----------------------GPGGTGGSGSSPNDPVT-NICQAADK 345
Query: 192 LLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVS-GMNG 250
LF ++WAK +P FS+L L DQ++LL W EL + + +I V LLA ++
Sbjct: 346 QLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHR 405
Query: 251 DNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRN 310
++ S + I + L E+V++ R +R+D TE CL+ I+ F + + N
Sbjct: 406 NSAHSAGVGAIFDRV--LTELVSKMRDMRMDKTELGCLRAIILFNP-------DAKGLSN 456
Query: 311 AAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNV 370
+ + L+++ +L +Y +YP Q RF KLLL LPALRSI +E +FF K IG+
Sbjct: 457 PSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDT 516
Query: 371 PITRLLSDMYKS 382
PI L +M ++
Sbjct: 517 PIDTFLMEMLEA 528
>gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens]
Length = 445
Score = 184 bits (466), Expect = 2e-46
Identities = 120/365 (32%), Positives = 188/365 (51%), Gaps = 53/365 (14%)
Query: 16 CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRL 75
C +CGDR++GKHYG +CDGC GFF+RSIR++ Y C+ Q C VDK RNQCR CRL
Sbjct: 49 CAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQ--CVVDKDKRNQCRYCRL 106
Query: 76 KKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVT 135
+KC M K+AVQ+ER R ST R + F + +P+
Sbjct: 107 RKCFRAGMKKEAVQNER-DRISTRR-----------------STFDGSNIPS-------- 140
Query: 136 QLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVAT-ESVCESAARLLF 194
+ ++ R +S++ P + T + + ++A+ VCES + L
Sbjct: 141 --------INTLAQAEVRSRQISVSSPG-------SSTDINVKKIASIGDVCESMKQQLL 185
Query: 195 MSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTD 254
+ ++WAK +PAF L L DQ+ LL E +LG + ++ LL + + N+
Sbjct: 186 VLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMMYKDILLLGNNYVIHRNSC 245
Query: 255 SQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAI 314
+++++ + + L E+V F+++++D E+ACLK IV F + + + I
Sbjct: 246 EVEISRVANRV--LDELVRPFQEIQIDDNEYACLKAIVFF-------DPDAKGLSDPVKI 296
Query: 315 AALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITR 374
++ + Q+ L YI+ R RFG+LLLLLP L+SI+ IE++ F K G V I
Sbjct: 297 KNMRFQVQIGLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMVKIDN 356
Query: 375 LLSDM 379
LL +M
Sbjct: 357 LLQEM 361
>gi|31077209 hepatocyte nuclear factor 4 alpha isoform c [Homo
sapiens]
Length = 417
Score = 177 bits (450), Expect = 1e-44
Identities = 124/364 (34%), Positives = 178/364 (48%), Gaps = 50/364 (13%)
Query: 16 CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRL 75
C +CGDR++GKHYG +CDGC GFF+RS+R+N Y C+ Q C VDK RNQCR CRL
Sbjct: 60 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQ--CVVDKDKRNQCRYCRL 117
Query: 76 KKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVT 135
KKC M K+AVQ+ER R ST R + + ++LP+ A+
Sbjct: 118 KKCFRAGMKKEAVQNER-DRISTRR-----------------SSYEDSSLPS---INALL 156
Query: 136 QLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFM 195
Q E L+ T+P +NG + VCES L +
Sbjct: 157 QAE----VLSRQITSP---------------VSGINGDIRAKKIASIADVCESMKEQLLV 197
Query: 196 SIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDS 255
++WAK +PAF L L DQ+ LL E +LG + ++ V + LL +
Sbjct: 198 LVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSM-VFKDVLLLGNDYIVPRHCP 256
Query: 256 QKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIA 315
+ I+ L E+V F++L++D E+A LK I+ F + + + I
Sbjct: 257 ELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFF-------DPDAKGLSDPGKIK 309
Query: 316 ALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRL 375
L+ + Q++L YI+ R RFG+LLLLLP L+SI+ IE++ F K G I L
Sbjct: 310 RLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNL 369
Query: 376 LSDM 379
L +M
Sbjct: 370 LQEM 373
>gi|31077207 hepatocyte nuclear factor 4 alpha isoform a [Homo
sapiens]
Length = 464
Score = 177 bits (450), Expect = 1e-44
Identities = 124/364 (34%), Positives = 178/364 (48%), Gaps = 50/364 (13%)
Query: 16 CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRL 75
C +CGDR++GKHYG +CDGC GFF+RS+R+N Y C+ Q C VDK RNQCR CRL
Sbjct: 60 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQ--CVVDKDKRNQCRYCRL 117
Query: 76 KKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVT 135
KKC M K+AVQ+ER R ST R + + ++LP+ A+
Sbjct: 118 KKCFRAGMKKEAVQNER-DRISTRR-----------------SSYEDSSLPS---INALL 156
Query: 136 QLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFM 195
Q E L+ T+P +NG + VCES L +
Sbjct: 157 QAE----VLSRQITSP---------------VSGINGDIRAKKIASIADVCESMKEQLLV 197
Query: 196 SIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDS 255
++WAK +PAF L L DQ+ LL E +LG + ++ V + LL +
Sbjct: 198 LVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSM-VFKDVLLLGNDYIVPRHCP 256
Query: 256 QKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIA 315
+ I+ L E+V F++L++D E+A LK I+ F + + + I
Sbjct: 257 ELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFF-------DPDAKGLSDPGKIK 309
Query: 316 ALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRL 375
L+ + Q++L YI+ R RFG+LLLLLP L+SI+ IE++ F K G I L
Sbjct: 310 RLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNL 369
Query: 376 LSDM 379
L +M
Sbjct: 370 LQEM 373
>gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo
sapiens]
Length = 474
Score = 177 bits (450), Expect = 1e-44
Identities = 124/364 (34%), Positives = 178/364 (48%), Gaps = 50/364 (13%)
Query: 16 CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRL 75
C +CGDR++GKHYG +CDGC GFF+RS+R+N Y C+ Q C VDK RNQCR CRL
Sbjct: 60 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQ--CVVDKDKRNQCRYCRL 117
Query: 76 KKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVT 135
KKC M K+AVQ+ER R ST R + + ++LP+ A+
Sbjct: 118 KKCFRAGMKKEAVQNER-DRISTRR-----------------SSYEDSSLPS---INALL 156
Query: 136 QLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFM 195
Q E L+ T+P +NG + VCES L +
Sbjct: 157 QAE----VLSRQITSP---------------VSGINGDIRAKKIASIADVCESMKEQLLV 197
Query: 196 SIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDS 255
++WAK +PAF L L DQ+ LL E +LG + ++ V + LL +
Sbjct: 198 LVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSM-VFKDVLLLGNDYIVPRHCP 256
Query: 256 QKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIA 315
+ I+ L E+V F++L++D E+A LK I+ F + + + I
Sbjct: 257 ELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFF-------DPDAKGLSDPGKIK 309
Query: 316 ALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRL 375
L+ + Q++L YI+ R RFG+LLLLLP L+SI+ IE++ F K G I L
Sbjct: 310 RLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNL 369
Query: 376 LSDM 379
L +M
Sbjct: 370 LQEM 373
>gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo
sapiens]
Length = 395
Score = 177 bits (450), Expect = 1e-44
Identities = 124/364 (34%), Positives = 178/364 (48%), Gaps = 50/364 (13%)
Query: 16 CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRL 75
C +CGDR++GKHYG +CDGC GFF+RS+R+N Y C+ Q C VDK RNQCR CRL
Sbjct: 38 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQ--CVVDKDKRNQCRYCRL 95
Query: 76 KKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVT 135
KKC M K+AVQ+ER R ST R + + ++LP+ A+
Sbjct: 96 KKCFRAGMKKEAVQNER-DRISTRR-----------------SSYEDSSLPS---INALL 134
Query: 136 QLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFM 195
Q E L+ T+P +NG + VCES L +
Sbjct: 135 QAE----VLSRQITSP---------------VSGINGDIRAKKIASIADVCESMKEQLLV 175
Query: 196 SIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDS 255
++WAK +PAF L L DQ+ LL E +LG + ++ V + LL +
Sbjct: 176 LVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSM-VFKDVLLLGNDYIVPRHCP 234
Query: 256 QKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIA 315
+ I+ L E+V F++L++D E+A LK I+ F + + + I
Sbjct: 235 ELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFF-------DPDAKGLSDPGKIK 287
Query: 316 ALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRL 375
L+ + Q++L YI+ R RFG+LLLLLP L+SI+ IE++ F K G I L
Sbjct: 288 RLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNL 347
Query: 376 LSDM 379
L +M
Sbjct: 348 LQEM 351
>gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo
sapiens]
Length = 442
Score = 177 bits (450), Expect = 1e-44
Identities = 124/364 (34%), Positives = 178/364 (48%), Gaps = 50/364 (13%)
Query: 16 CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRL 75
C +CGDR++GKHYG +CDGC GFF+RS+R+N Y C+ Q C VDK RNQCR CRL
Sbjct: 38 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQ--CVVDKDKRNQCRYCRL 95
Query: 76 KKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVT 135
KKC M K+AVQ+ER R ST R + + ++LP+ A+
Sbjct: 96 KKCFRAGMKKEAVQNER-DRISTRR-----------------SSYEDSSLPS---INALL 134
Query: 136 QLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFM 195
Q E L+ T+P +NG + VCES L +
Sbjct: 135 QAE----VLSRQITSP---------------VSGINGDIRAKKIASIADVCESMKEQLLV 175
Query: 196 SIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDS 255
++WAK +PAF L L DQ+ LL E +LG + ++ V + LL +
Sbjct: 176 LVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSM-VFKDVLLLGNDYIVPRHCP 234
Query: 256 QKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIA 315
+ I+ L E+V F++L++D E+A LK I+ F + + + I
Sbjct: 235 ELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFF-------DPDAKGLSDPGKIK 287
Query: 316 ALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRL 375
L+ + Q++L YI+ R RFG+LLLLLP L+SI+ IE++ F K G I L
Sbjct: 288 RLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNL 347
Query: 376 LSDM 379
L +M
Sbjct: 348 LQEM 351
>gi|71725339 hepatocyte nuclear factor 4 alpha isoform d [Homo
sapiens]
Length = 452
Score = 177 bits (450), Expect = 1e-44
Identities = 124/364 (34%), Positives = 178/364 (48%), Gaps = 50/364 (13%)
Query: 16 CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRL 75
C +CGDR++GKHYG +CDGC GFF+RS+R+N Y C+ Q C VDK RNQCR CRL
Sbjct: 38 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQ--CVVDKDKRNQCRYCRL 95
Query: 76 KKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVT 135
KKC M K+AVQ+ER R ST R + + ++LP+ A+
Sbjct: 96 KKCFRAGMKKEAVQNER-DRISTRR-----------------SSYEDSSLPS---INALL 134
Query: 136 QLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFM 195
Q E L+ T+P +NG + VCES L +
Sbjct: 135 QAE----VLSRQITSP---------------VSGINGDIRAKKIASIADVCESMKEQLLV 175
Query: 196 SIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDS 255
++WAK +PAF L L DQ+ LL E +LG + ++ V + LL +
Sbjct: 176 LVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSM-VFKDVLLLGNDYIVPRHCP 234
Query: 256 QKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIA 315
+ I+ L E+V F++L++D E+A LK I+ F + + + I
Sbjct: 235 ELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFF-------DPDAKGLSDPGKIK 287
Query: 316 ALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRL 375
L+ + Q++L YI+ R RFG+LLLLLP L+SI+ IE++ F K G I L
Sbjct: 288 RLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNL 347
Query: 376 LSDM 379
L +M
Sbjct: 348 LQEM 351
>gi|238550159 estrogen-related receptor beta [Homo sapiens]
Length = 508
Score = 165 bits (417), Expect = 7e-41
Identities = 112/371 (30%), Positives = 177/371 (47%), Gaps = 46/371 (12%)
Query: 16 CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRL 75
C VCGD +SG HYGV +C+ C FFKR+I+ N Y C + N+ C + K R C+ACR
Sbjct: 103 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNE--CEITKRRRKSCQACRF 160
Query: 76 KKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHF---PSAALPAPAFFT 132
KCL+V M K+ V+ +R +R Y R E+ P A P +
Sbjct: 161 MKCLKVGMLKEGVRLDR------VRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVS 214
Query: 133 AVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPH-EVNGTPMYLYEVATESVCESAAR 191
+ EP L A P P P ++ A ++C+ A R
Sbjct: 215 YLLVAEPDKL----------------YAMPPPGMPEGDIK---------ALTTLCDLADR 249
Query: 192 LLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGD 251
L + I WAK +P FS+LSL DQ+ LL+ AW E+ +LGI ++P D + A + +
Sbjct: 250 ELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDE 309
Query: 252 NTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNA 311
+ +L ++ +A+ ++V R+++L+++ EF LK + + S+ +
Sbjct: 310 --EHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALAL-------ANSDSMYIEDL 360
Query: 312 AAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVP 371
A+ LQD L Y ++ +P R GKLLL LP LR + ++ + K G VP
Sbjct: 361 EAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVP 420
Query: 372 ITRLLSDMYKS 382
+ +L +M ++
Sbjct: 421 MHKLFLEMLEA 431
>gi|45545429 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 164 bits (414), Expect = 2e-40
Identities = 111/367 (30%), Positives = 173/367 (47%), Gaps = 38/367 (10%)
Query: 16 CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRL 75
C VCGD +SG HYGV +C+ C FFKR+I+ N Y C + N+ C + K R C+ACR
Sbjct: 105 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNE--CEITKRRRKSCQACRF 162
Query: 76 KKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVT 135
KCL+V M K+ V+ +R +R Y R EN + P PA + +
Sbjct: 163 MKCLKVGMLKEGVRLDR------VRGGRQKYKRRIDAENSPYLN-PQLVQPAKKPYNKIV 215
Query: 136 QLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFM 195
+ PE+ A P P P A ++C+ A R L +
Sbjct: 216 S--------HLLVAEPEK----IYAMPDPTVPDSDIK--------ALTTLCDLADRELVV 255
Query: 196 SIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDS 255
I WAK +P FSTLSL DQ+ LL+ AW E+ +LG+ ++ + + A + + D
Sbjct: 256 IIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDE--DQ 313
Query: 256 QKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIA 315
KL ++ A+ ++V +++ ++L+ EF LK I + S+ + A+
Sbjct: 314 SKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIAL-------ANSDSMHIEDVEAVQ 366
Query: 316 ALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRL 375
LQD L Y ++ P R GK+L+ LP LR S ++ + K G VP+ +L
Sbjct: 367 KLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKL 426
Query: 376 LSDMYKS 382
+M ++
Sbjct: 427 FLEMLEA 433
>gi|45545427 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 164 bits (414), Expect = 2e-40
Identities = 111/367 (30%), Positives = 173/367 (47%), Gaps = 38/367 (10%)
Query: 16 CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRL 75
C VCGD +SG HYGV +C+ C FFKR+I+ N Y C + N+ C + K R C+ACR
Sbjct: 105 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNE--CEITKRRRKSCQACRF 162
Query: 76 KKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVT 135
KCL+V M K+ V+ +R +R Y R EN + P PA + +
Sbjct: 163 MKCLKVGMLKEGVRLDR------VRGGRQKYKRRIDAENSPYLN-PQLVQPAKKPYNKIV 215
Query: 136 QLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFM 195
+ PE+ A P P P A ++C+ A R L +
Sbjct: 216 S--------HLLVAEPEK----IYAMPDPTVPDSDIK--------ALTTLCDLADRELVV 255
Query: 196 SIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDS 255
I WAK +P FSTLSL DQ+ LL+ AW E+ +LG+ ++ + + A + + D
Sbjct: 256 IIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDE--DQ 313
Query: 256 QKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIA 315
KL ++ A+ ++V +++ ++L+ EF LK I + S+ + A+
Sbjct: 314 SKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIAL-------ANSDSMHIEDVEAVQ 366
Query: 316 ALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRL 375
LQD L Y ++ P R GK+L+ LP LR S ++ + K G VP+ +L
Sbjct: 367 KLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKL 426
Query: 376 LSDMYKS 382
+M ++
Sbjct: 427 FLEMLEA 433
>gi|45545433 estrogen-related receptor gamma isoform 1 [Homo
sapiens]
Length = 458
Score = 164 bits (414), Expect = 2e-40
Identities = 111/367 (30%), Positives = 173/367 (47%), Gaps = 38/367 (10%)
Query: 16 CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRL 75
C VCGD +SG HYGV +C+ C FFKR+I+ N Y C + N+ C + K R C+ACR
Sbjct: 128 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNE--CEITKRRRKSCQACRF 185
Query: 76 KKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVT 135
KCL+V M K+ V+ +R +R Y R EN + P PA + +
Sbjct: 186 MKCLKVGMLKEGVRLDR------VRGGRQKYKRRIDAENSPYLN-PQLVQPAKKPYNKIV 238
Query: 136 QLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFM 195
+ PE+ A P P P A ++C+ A R L +
Sbjct: 239 S--------HLLVAEPEK----IYAMPDPTVPDSDIK--------ALTTLCDLADRELVV 278
Query: 196 SIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDS 255
I WAK +P FSTLSL DQ+ LL+ AW E+ +LG+ ++ + + A + + D
Sbjct: 279 IIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDE--DQ 336
Query: 256 QKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIA 315
KL ++ A+ ++V +++ ++L+ EF LK I + S+ + A+
Sbjct: 337 SKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIAL-------ANSDSMHIEDVEAVQ 389
Query: 316 ALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRL 375
LQD L Y ++ P R GK+L+ LP LR S ++ + K G VP+ +L
Sbjct: 390 KLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKL 449
Query: 376 LSDMYKS 382
+M ++
Sbjct: 450 FLEMLEA 456
>gi|197209821 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 164 bits (414), Expect = 2e-40
Identities = 111/367 (30%), Positives = 173/367 (47%), Gaps = 38/367 (10%)
Query: 16 CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRL 75
C VCGD +SG HYGV +C+ C FFKR+I+ N Y C + N+ C + K R C+ACR
Sbjct: 105 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNE--CEITKRRRKSCQACRF 162
Query: 76 KKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVT 135
KCL+V M K+ V+ +R +R Y R EN + P PA + +
Sbjct: 163 MKCLKVGMLKEGVRLDR------VRGGRQKYKRRIDAENSPYLN-PQLVQPAKKPYNKIV 215
Query: 136 QLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFM 195
+ PE+ A P P P A ++C+ A R L +
Sbjct: 216 S--------HLLVAEPEK----IYAMPDPTVPDSDIK--------ALTTLCDLADRELVV 255
Query: 196 SIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDS 255
I WAK +P FSTLSL DQ+ LL+ AW E+ +LG+ ++ + + A + + D
Sbjct: 256 IIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDE--DQ 313
Query: 256 QKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIA 315
KL ++ A+ ++V +++ ++L+ EF LK I + S+ + A+
Sbjct: 314 SKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIAL-------ANSDSMHIEDVEAVQ 366
Query: 316 ALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRL 375
LQD L Y ++ P R GK+L+ LP LR S ++ + K G VP+ +L
Sbjct: 367 KLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKL 426
Query: 376 LSDMYKS 382
+M ++
Sbjct: 427 FLEMLEA 433
>gi|223555953 nuclear receptor subfamily 2, group F, member 2
isoform c [Homo sapiens]
Length = 261
Score = 159 bits (403), Expect = 3e-39
Identities = 78/200 (39%), Positives = 124/200 (62%), Gaps = 7/200 (3%)
Query: 183 ESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTL 242
E++CE AAR+LF +++WA+++P F L + DQ+ LL W ELFVL AQ ++P+ L
Sbjct: 57 ENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPL 116
Query: 243 LAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSG 302
LA +G++ + ++ + I+ QE V + + L +D+ E++CLK IV F
Sbjct: 117 LAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFT------- 169
Query: 303 SELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVF 362
S+ + A + +LQ+++Q L Y+ ++YP QP RFGKLLL LP+LR++S S IE++F
Sbjct: 170 SDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLF 229
Query: 363 FKKTIGNVPITRLLSDMYKS 382
F + +G PI L+ DM S
Sbjct: 230 FVRLVGKTPIETLIRDMLLS 249
>gi|223555951 nuclear receptor subfamily 2, group F, member 2
isoform c [Homo sapiens]
Length = 261
Score = 159 bits (403), Expect = 3e-39
Identities = 78/200 (39%), Positives = 124/200 (62%), Gaps = 7/200 (3%)
Query: 183 ESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTL 242
E++CE AAR+LF +++WA+++P F L + DQ+ LL W ELFVL AQ ++P+ L
Sbjct: 57 ENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPL 116
Query: 243 LAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSG 302
LA +G++ + ++ + I+ QE V + + L +D+ E++CLK IV F
Sbjct: 117 LAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFT------- 169
Query: 303 SELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVF 362
S+ + A + +LQ+++Q L Y+ ++YP QP RFGKLLL LP+LR++S S IE++F
Sbjct: 170 SDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLF 229
Query: 363 FKKTIGNVPITRLLSDMYKS 382
F + +G PI L+ DM S
Sbjct: 230 FVRLVGKTPIETLIRDMLLS 249
>gi|223555949 nuclear receptor subfamily 2, group F, member 2
isoform b [Homo sapiens]
Length = 281
Score = 159 bits (403), Expect = 3e-39
Identities = 78/200 (39%), Positives = 124/200 (62%), Gaps = 7/200 (3%)
Query: 183 ESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTL 242
E++CE AAR+LF +++WA+++P F L + DQ+ LL W ELFVL AQ ++P+ L
Sbjct: 77 ENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPL 136
Query: 243 LAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSG 302
LA +G++ + ++ + I+ QE V + + L +D+ E++CLK IV F
Sbjct: 137 LAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFT------- 189
Query: 303 SELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVF 362
S+ + A + +LQ+++Q L Y+ ++YP QP RFGKLLL LP+LR++S S IE++F
Sbjct: 190 SDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLF 249
Query: 363 FKKTIGNVPITRLLSDMYKS 382
F + +G PI L+ DM S
Sbjct: 250 FVRLVGKTPIETLIRDMLLS 269
>gi|170295804 estrogen receptor alpha isoform 4 [Homo sapiens]
Length = 595
Score = 155 bits (393), Expect = 4e-38
Identities = 114/368 (30%), Positives = 169/368 (45%), Gaps = 13/368 (3%)
Query: 16 CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRL 75
C VC D +SG HYGV++C+GC FFKRSI+ + Y+C + NQ C +DK R C+ACRL
Sbjct: 185 CAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQ--CTIDKNRRKSCQACRL 242
Query: 76 KKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVT 135
+KC EV M K ++ +R K+ G E A + P+P +
Sbjct: 243 RKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLM---IK 299
Query: 136 QLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFM 195
+ + + L A+S T ++ L P E + T + + A R L
Sbjct: 300 RSKKNSL---ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVH 356
Query: 196 SIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDS 255
I WAK VP F L+L DQ+ LLE AW E+ ++G+ W LL + D
Sbjct: 357 MINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLV-WRSMEHPGKLLFAPNLLLDRNQG 415
Query: 256 QKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKA-VPTHSGSELRSFRNAAAI 314
+ + ++ L +RFR + L EF CLK I+ + V T S L+S I
Sbjct: 416 KCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHI 475
Query: 315 AALQDEAQLTLNSYIHTRYPT---QPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVP 371
+ D+ TL + T Q R +LLL+L +R +S +E ++ K VP
Sbjct: 476 HRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVP 535
Query: 372 ITRLLSDM 379
+ LL +M
Sbjct: 536 LYDLLLEM 543
>gi|170295802 estrogen receptor alpha isoform 3 [Homo sapiens]
Length = 595
Score = 155 bits (393), Expect = 4e-38
Identities = 114/368 (30%), Positives = 169/368 (45%), Gaps = 13/368 (3%)
Query: 16 CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRL 75
C VC D +SG HYGV++C+GC FFKRSI+ + Y+C + NQ C +DK R C+ACRL
Sbjct: 185 CAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQ--CTIDKNRRKSCQACRL 242
Query: 76 KKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVT 135
+KC EV M K ++ +R K+ G E A + P+P +
Sbjct: 243 RKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLM---IK 299
Query: 136 QLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFM 195
+ + + L A+S T ++ L P E + T + + A R L
Sbjct: 300 RSKKNSL---ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVH 356
Query: 196 SIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDS 255
I WAK VP F L+L DQ+ LLE AW E+ ++G+ W LL + D
Sbjct: 357 MINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLV-WRSMEHPGKLLFAPNLLLDRNQG 415
Query: 256 QKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKA-VPTHSGSELRSFRNAAAI 314
+ + ++ L +RFR + L EF CLK I+ + V T S L+S I
Sbjct: 416 KCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHI 475
Query: 315 AALQDEAQLTLNSYIHTRYPT---QPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVP 371
+ D+ TL + T Q R +LLL+L +R +S +E ++ K VP
Sbjct: 476 HRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVP 535
Query: 372 ITRLLSDM 379
+ LL +M
Sbjct: 536 LYDLLLEM 543
>gi|170295800 estrogen receptor alpha isoform 2 [Homo sapiens]
Length = 595
Score = 155 bits (393), Expect = 4e-38
Identities = 114/368 (30%), Positives = 169/368 (45%), Gaps = 13/368 (3%)
Query: 16 CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRL 75
C VC D +SG HYGV++C+GC FFKRSI+ + Y+C + NQ C +DK R C+ACRL
Sbjct: 185 CAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQ--CTIDKNRRKSCQACRL 242
Query: 76 KKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVT 135
+KC EV M K ++ +R K+ G E A + P+P +
Sbjct: 243 RKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLM---IK 299
Query: 136 QLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFM 195
+ + + L A+S T ++ L P E + T + + A R L
Sbjct: 300 RSKKNSL---ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVH 356
Query: 196 SIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDS 255
I WAK VP F L+L DQ+ LLE AW E+ ++G+ W LL + D
Sbjct: 357 MINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLV-WRSMEHPGKLLFAPNLLLDRNQG 415
Query: 256 QKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKA-VPTHSGSELRSFRNAAAI 314
+ + ++ L +RFR + L EF CLK I+ + V T S L+S I
Sbjct: 416 KCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHI 475
Query: 315 AALQDEAQLTLNSYIHTRYPT---QPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVP 371
+ D+ TL + T Q R +LLL+L +R +S +E ++ K VP
Sbjct: 476 HRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVP 535
Query: 372 ITRLLSDM 379
+ LL +M
Sbjct: 536 LYDLLLEM 543
>gi|62821794 estrogen receptor alpha isoform 1 [Homo sapiens]
Length = 595
Score = 155 bits (393), Expect = 4e-38
Identities = 114/368 (30%), Positives = 169/368 (45%), Gaps = 13/368 (3%)
Query: 16 CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRL 75
C VC D +SG HYGV++C+GC FFKRSI+ + Y+C + NQ C +DK R C+ACRL
Sbjct: 185 CAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQ--CTIDKNRRKSCQACRL 242
Query: 76 KKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVT 135
+KC EV M K ++ +R K+ G E A + P+P +
Sbjct: 243 RKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLM---IK 299
Query: 136 QLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFM 195
+ + + L A+S T ++ L P E + T + + A R L
Sbjct: 300 RSKKNSL---ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVH 356
Query: 196 SIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDS 255
I WAK VP F L+L DQ+ LLE AW E+ ++G+ W LL + D
Sbjct: 357 MINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLV-WRSMEHPGKLLFAPNLLLDRNQG 415
Query: 256 QKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKA-VPTHSGSELRSFRNAAAI 314
+ + ++ L +RFR + L EF CLK I+ + V T S L+S I
Sbjct: 416 KCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHI 475
Query: 315 AALQDEAQLTLNSYIHTRYPT---QPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVP 371
+ D+ TL + T Q R +LLL+L +R +S +E ++ K VP
Sbjct: 476 HRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVP 535
Query: 372 ITRLLSDM 379
+ LL +M
Sbjct: 536 LYDLLLEM 543
>gi|10835013 estrogen receptor beta isoform 1 [Homo sapiens]
Length = 530
Score = 149 bits (375), Expect = 5e-36
Identities = 113/378 (29%), Positives = 173/378 (45%), Gaps = 46/378 (12%)
Query: 16 CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRL 75
C VC D +SG HYGV++C+GC FFKRSI+ + Y+C + NQ C +DK R C+ACRL
Sbjct: 149 CAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQ--CTIDKNRRKSCQACRL 206
Query: 76 KKCLEVNMNKDAVQHERGPRTSTIRKQVA---LYFRGHKEENGAAAHFPSAALPAPAFFT 132
+KC EV M K + ER R++ A L+ G + +G A
Sbjct: 207 RKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHA-------------- 252
Query: 133 AVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVAT--ESVCESAA 190
P EL + +PE Q +++L + P PH + P + A+ S+ + A
Sbjct: 253 ------PRVRELLLDALSPE-QLVLTLLEAEP--PHVLISRPSAPFTEASMMMSLTKLAD 303
Query: 191 RLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNG 250
+ L I WAK +P F LSL DQ+ LLE W E+ ++G+ W L+ +
Sbjct: 304 KELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGL-MWRSIDHPGKLIFAPDLVL 362
Query: 251 DNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKA---------VPTHS 301
D + + + I+ L +RFR+L+L E+ C+K ++ + S
Sbjct: 363 DRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADS 422
Query: 302 GSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEV 361
+L NA A + A+ ++S Q R LL+LL +R S +E +
Sbjct: 423 SRKLAHLLNAVTDALVWVIAKSGISS------QQQSMRLANLLMLLSHVRHASNKGMEHL 476
Query: 362 FFKKTIGNVPITRLLSDM 379
K VP+ LL +M
Sbjct: 477 LNMKCKNVVPVYDLLLEM 494
>gi|18860920 estrogen-related receptor alpha [Homo sapiens]
Length = 423
Score = 147 bits (371), Expect = 2e-35
Identities = 117/378 (30%), Positives = 179/378 (47%), Gaps = 47/378 (12%)
Query: 16 CKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRL 75
C VCGD +SG HYGV +C+ C FFKR+I+ + Y C + N+ C + K R C+ACR
Sbjct: 79 CLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNE--CEITKRRRKACQACRF 136
Query: 76 KKCLEVNMNKDAVQHER---GPRTSTIRKQV-ALYFRGHKEENG-AAAHFP-SAALPAPA 129
KCL V M K+ V+ +R G + R +V L F G A A P A P A
Sbjct: 137 TKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAAPVNA 196
Query: 130 FFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESA 189
+ + +EP L A P P P +L VAT +C+
Sbjct: 197 LVSHLLVVEPEKL----------------YAMPDPAGPDG------HLPAVAT--LCDLF 232
Query: 190 ARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVS-GM 248
R + ++I WAKS+P FS+LSL DQ+ +L+ W E+ VLG+AQ ++P+ A +
Sbjct: 233 DREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVL 292
Query: 249 NGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSF 308
+ + + L ++ + AL ++V R + LRL+ E+ LK + + H
Sbjct: 293 DEEGARAAGLGELGA---ALLQLVRRLQALRLEREEYVLLKALALANSDSVH-------I 342
Query: 309 RNAAAIAALQDEAQLTLNSYIHTRY----PTQPCRFGKLLLLLPALRSISPSTIEEVFFK 364
+A A+ L++ L Y R + R G+LLL LP LR + + +
Sbjct: 343 EDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGV 402
Query: 365 KTIGNVPITRLLSDMYKS 382
K G VP+ +L +M ++
Sbjct: 403 KLEGKVPMHKLFLEMLEA 420
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.133 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,847,909
Number of Sequences: 37866
Number of extensions: 676750
Number of successful extensions: 2058
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 122
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 1618
Number of HSP's gapped (non-prelim): 234
length of query: 385
length of database: 18,247,518
effective HSP length: 104
effective length of query: 281
effective length of database: 14,309,454
effective search space: 4020956574
effective search space used: 4020956574
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.